Cushing syndrome as a presenting symptom of renal tumors in children.
Cushing syndrome as the presenting symptom of a malignant renal tumor in children is rare. We report the first case of paraneoplastic Cushing syndrome due to a Wilms tumor, in which clinical and biological signs of hypercortisolism regressed during preoperative chemotherapy. Additionally, we reviewed the literature on paraneoplastic Cushing syndrome secondary to pediatric renal tumors.
Department of Pediatric Oncology/Hematology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
H
H
Segers
J C
JC
van der Heyden
E L T
EL
van den Akker
R R
RR
de Krijger
C M
CM
Zwaan
M M
MM
van den Heuvel-Eibrink
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007680:Kidney Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D009392:Nephrectomy; D010257:Paraneoplastic Syndromes / Q000209:etiology; D011878:Radiotherapy; D009396:Wilms Tumor / Q000150:complications* / Q000473:pathology / Q000628:therapy
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone