Organohalogen contaminants and metabolites in cerebrospinal fluid and cerebellum gray matter in short-beaked common dolphins and Atlantic white-sided dolphins from the western North Atlantic.
Concentrations of several congeners and classes of organohalogen contaminants (OHCs) and/or their metabolites, namely organochlorine pesticides (OCs), polychlorinated biphenyls (PCBs), hydroxylated-PCBs (OH-PCBs), methylsulfonyl-PCBs (MeSO(2)-PCBs), polybrominated diphenyl ether (PBDE) flame retardants, and OH-PBDEs, were measured in cerebrospinal fluid (CSF) of short-beaked common dolphins (n = 2), Atlantic white-sided dolphins (n = 8), and gray seal (n = 1) from the western North Atlantic. In three Atlantic white-sided dolphins, cerebellum gray matter (GM) was also analyzed. The levels of OCs, PCBs, MeSO(2)-PCBs, PBDEs, and OH-PBDEs in cerebellum GM were higher than the concentrations in CSF. 4-OH-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) was the only detectable OH-PCB congener present in CSF. The sum (Sigma) OH-PCBs/Sigma PCB concentration ratio in CSF was approximately two to three orders of magnitude greater than the ratio in cerebellum GM for dolphins.
Montie
Eric W
EW
Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA. emontie@marine.usf.edu
Reddy
Christopher M
CM
Gebbink
Wouter A
WA
Touhey
Katie E
KE
Hahn
Mark E
ME
Letcher
Robert J
RJ
D000818:Animals; D001267:Atlantic Ocean; D002531:Cerebellum / Q000378:metabolism*; D050696:Common Dolphins / Q000134:cerebrospinal fluid / Q000378:metabolism; D004289:Dolphins / Q000134:cerebrospinal fluid / Q000378:metabolism*; D004784:Environmental Monitoring; D005260:Female; D006846:Hydrocarbons, Halogenated / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D011078:Polychlorinated Biphenyls / Q000134:cerebrospinal fluid / Q000378:metabolism; D046048:Seals, Earless / Q000134:cerebrospinal fluid / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000134:cerebrospinal fluid / Q000378:metabolism*; D014877:Water Pollution, Chemical / Q000706:statistics & numerical data
D006846:Hydrocarbons, Halogenated; D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls