Effect of folic acid on methotrexate induction of sulfotransferases in rats.
Our earlier investigation showed that MTX is an inducer of rat and human sulfotransferases. Here we report that folic acid treatment inhibited MTX induction of aryl sulfotransferase (AST-IV) in female rat liver and hydroxysteroid sulfotransferase (STa) in male rat liver. This is important for understanding the clinical mechanisms of MTX.
Dutta
Sangita Maiti
SM
Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Maiti
Smarajit
S
Chen
Guangping
G
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D015239:Arylsulfotransferase / Q000187:drug effects* / Q000378:metabolism; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005492:Folic Acid / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D012333:RNA, Messenger / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D015238:Sulfotransferases / Q000187:drug effects* / Q000378:metabolism
D000964:Antimetabolites, Antineoplastic; D012333:RNA, Messenger; D005492:Folic Acid; D015238:Sulfotransferases; D015239:Arylsulfotransferase; C028152:alcohol sulfotransferase; D008727:Methotrexate