Synchronous multifocal HPV-related neoplasm involving both the genital tract and the head-and-neck area: a case report of Fanconi anemia.
We report the case of a 32-year-old woman who presented with multiple squamous cell neoplasms synchronously arising in the cervix, vulva, oral cavity and oropharynx. During the period when the patient was treated by radiotherapy, she developed severe radiation mucositis and pancytopenia. Immunofluorescence staining for foci of the monoubiquitinated form of FANCD2 revealed a complete absence of such foci in all cancer tissues that were examined.
Han
Tae-Jin
TJ
Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea.
Lee
Chang-Hun
CH
Yoo
Chong-Woo
CW
Shin
Hye-Jin
HJ
Park
Hyun-Jin
HJ
Cho
Kwan Ho
KH
Park
Joo-Yong
JY
Choi
Sung-Won
SW
Kim
Joo-Young
JY
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000821:virology; D005199:Fanconi Anemia / Q000150:complications*; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications* / Q000821:virology; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000821:virology; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology