Therapeutic efficacy of 2-methoxyestradiol microcrystals encapsulated within polyelectrolyte multilayers.
Development of a novel formulation of anticancer drugs to improve their water-solubility and bioavailability remains a great challenge. Herein, the potential anticancer agent 2-methoxyestradiol (2-ME) was selected as a model drug and was encapsulated within polyelectrolyte (PE) multilayers by layer-by-layer deposition of oppositely charged PEs onto the drug microcrystal surfaces. Cell viability and morphology observation of two cell lines reveal that the PE multilayer-encapsulated 2-ME microcrystals markedly decrease the cell viability, displaying similar inhibitory effect to that of the conventional formulation of 2-ME dissolved in ethanol. The current approach to encapsulate hydrophobic drug microparticles may be useful for formulating different drugs for a variety of biological applications.
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI48109, USA.
Su He
SH
Wang
Xiangyang
X
Shi
Xisui
X
Chen
James R
JR
Baker
D000077584:2-Methoxyestradiol; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002460:Cell Line / Q000187:drug effects; D002470:Cell Survival; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D003460:Crystallization; D004958:Estradiol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D008422:Materials Testing; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D051381:Rats
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D011108:Polymers; D004958:Estradiol; D000077584:2-Methoxyestradiol