Involvement of cytochromes P450 2D6, 2B6 and 2C19 in the metabolism of (-)-deprenyl and N-methyl,N-propargylphenylethylamine.
The metabolism of (-)-deprenyl (N-methyl,N-propargylamphetamine) and N-methyl,N-propargylphenyl-ethylamine (MPPE), monoamine oxidase inhibitors with neuroprotective properties, was studied using human liver microsomes and cDNA-expressed cytochrome P450 (CYP) enzymes. The metabolic pathways of MPPE parallel those of (-)-deprenyl, but some marked differences were observed, particularly with regard to the contributions of CYP2B6 and CYP2D6.
Rittenbach
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KA
Neurochemical Research Unit, Department of Psychiatry, 1E7 Mackenzie Centre, University of Alberta, Edmonton, Alberta, Canada.
Baker
G B
GB
D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D065702:Cytochrome P-450 CYP2B6; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism*; D018076:DNA, Complementary; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism; D018696:Neuroprotective Agents / Q000378:metabolism; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D012642:Selegiline / Q000031:analogs & derivatives* / Q000378:metabolism
D018076:DNA, Complementary; D008996:Monoamine Oxidase Inhibitors; C508639:N-Methyl,N-propargyphenylethylamine; D018696:Neuroprotective Agents; D012642:Selegiline; D001189:Aryl Hydrocarbon Hydroxylases; C585599:CYP2B6 protein, human; C045793:CYP2C19 protein, human; D065702:Cytochrome P-450 CYP2B6; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6; D010089:Oxidoreductases, N-Demethylating