Organocatalytic asymmetric synthesis of chiral fluorinated quaternary carbon containing beta-ketoesters.
Organocatalytic enantioselective conjugate addition of alpha-fluoroketoesters to nitroolefins efficiently catalyzed by a cinchona alkaloid-derivative affords versatile non-enolizable ketoesters by forming two consecutive fluorinated quaternary and tertiary chiral carbon centers with excellent enantioselectivity.
Li
Hao
H
Department of Chemistry, University of New Mexico, Albuquerque, NM 87131, USA.
Zhang
Shilei
S
Yu
Chenguang
C
Song
Xixi
X
Wang
Wei
W
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry*; D013237:Stereoisomerism
D004952:Esters; D009930:Organic Chemicals; D005461:Fluorine; D002244:Carbon