Acute severe chromium poisoning after dermal exposure to hexavalent chromium.
Severe acute chromium poisoning related to dermal involvement has rarely been reported in the literature. We report a case of acute severe chromium poisoning through skin exposure as a result of a chemical burn of 15% of the body surface area and multiple organ failure after short-term exposure. Medical interventions, including mechanical ventilation, continuous venovenous hemofiltration, and plasmapheresis were performed. In addition, a chelating agent, dimercaptopropane sulfonic acid, was infused intravenously, combined with intravenous N-acetylcysteine and ascorbic acid as adjuvant therapy. The patient was discharged on day 33 without long-term sequelae. The consequence of transdermal exposure of hexavalent chromium should not be overlooked.
Division of Clinical Toxicology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
Chun-Chi
CC
Lin
Ming-Ling
ML
Wu
Chen-Chang
CC
Yang
Jiin
J
Ger
Wei-Jen
WJ
Tsai
Jou-Fang
JF
Deng
D000328:Adult; D002057:Burns, Chemical / Q000150:complications*; D002857:Chromium / Q000493:pharmacokinetics / Q000506:poisoning*; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D012869:Skin Absorption
D002857:Chromium