[Islet transplantation as a clinical tool: present state and future perspectives].
Islet transplant is an innovative treatment for type 1 diabetic patients, which still lies between experimental and approved transplant therapy. Islet cells are seeded in a non-physiological territory where an uncertain fraction will be able to adapt and survive. Thus, the challenge lies in improving the whole procedure, employing the tools of cell biology, immunology and laboratory techniques, in order to reach the results obtained with whole organ transplant. This review describes the procedure, its progress to the present methodology and clinical results obtained. Future perspectives of islet transplantation in the light of recent biotechnological advances are also focused.
Núcleo de Terapia Celular e Molecular, Universidade de São Paulo.
Freddy Goldberg
FG
Eliaschewitz
Denise Reis
DR
Franco
Thiago Rennó
TR
Mares-Guia
Irene L
IL
Noronha
Leticia
L
Labriola
Mari Cleide
MC
Sogayar
D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000009:adverse effects / Q000379:methods / Q000639:trends