Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients.
BACKGROUND
Serum oxidative stress (OS) level has an important role in the inflammatory process of heart failure.


OBJECTIVE
The study was designed to analyze serum OS levels in chronic heart failure (HF) patients and to examine the relation between OS levels and other clinical and prognostic parameters of HF.


METHODS
We studied 82 consecutive chronic symptomatic HF patients with systolic LV dysfunction (ejection fraction <45%). The serum OS level was determined using thermochemiluminescence assay. We compared the serum OS levels with patients' clinical and prognostic parameters.


RESULTS
Higher serum OS levels were associated with higher New York Heart Association class (P = .01), worse renal function (serum urea, creatinine, and creatinine clearance) (P<.001) and higher serum levels of hs-C-reactive protein and N-terminal pro brain natriuretic peptide (P = .001, P<.001, respectively).


CONCLUSIONS
In chronic systolic HF patients, high serum OS levels correlate with advanced disease and known markers of poor prognosis.
Department of Cardiology, Lady Davis Carmel Medical Center, Haifa, Israel. ruthiea@wincol.ac.il
Offer
O
Amir
Hagar
H
Paz
Ori
O
Rogowski
Marina
M
Barshai
Moran
M
Sagiv
Sergei
S
Shnizer
Abraham Z
AZ
Reznick
Ruthie E
RE
Amir
D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D054143:Heart Failure, Systolic / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood*; D012720:Severity of Illness Index
D015415:Biomarkers; C099254:N-terminal proatrial natriuretic peptide; D011498:Protein Precursors; D009320:Atrial Natriuretic Factor