[The CAG repeat polymorphism in androgen receptor gene repeat and frequency of chosen parameters of metabolic syndrome in 45-65 aged men in Wroclaw population].
BACKGROUND
The activity of androgen receptor (AR) is modulated by a polymorphic CAG trinucleotide repeat in receptor gene. There are suggestion, that there are association between polymorphism androgen receptor gene and the occurrence typical features of metabolic syndrome in men. The metabolic syndrome is more frequent with aging. We knows, that polymorphism androgen receptor gene is associated with risk of prostate cancer and with occurrence Kennnedy's syndrome. However the association of this polymorphism for occurrence of hypertension, obesity and lipid and glucose concentration disturbance is not examined.


METHODS
The original study population consisted 268 randomly selected wroclaw population men aged 45-65. The physician examination include mensuration of blood pressure and antropometrical analysis. The men were coming on an empty stomach between 8.00 and 10.00 am for blood taken. The blood were taken for biochemical measurements and for genetic analysis CAG repeat in androgen receptor gene.


RESULTS
There is statistical significant differences between number of CAG repeat in men with normal and higher concentration of cholesterol LDL. There were no significant differences between number of CAG repeat in men in dependent of value of blood pressure and concentration of insulin, glucose, cholesterol HDL, total cholesterol and triglicerides.


CONCLUSIONS
The investigation results are not unambiguous with regard to influence of polymorphism androgen receptor gene for occurrence of metabolic syndrome in men. We found only association between number of CAG repeat an androgen receptor gene and concentration of cholesterol LDL (which it is as we knows atherogenic factor).
Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami, Wrocław. atrzmiel@poczta.onet.pl
Anna
A
Trzmiel-Bira
Alicja
A
Filus
Justyna
J
Kuliczkowska-Płaksej
Paweł
P
Jóźków
Małgorzata
M
Słowińska-Lisowska
Marek
M
Medraś
Andrzej
A
Milewicz
D000368:Aged; D008078:Cholesterol, LDL / Q000378:metabolism*; D005787:Gene Frequency; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics* / Q000378:metabolism*; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D018911:Trinucleotide Repeats
C410798:AR protein, human; D008078:Cholesterol, LDL; D011944:Receptors, Androgen