Invertebrate allorecognition: the origins of histocompatibility.
Alloimmune specificity and histocompatibility, driven by genetic polymorphism, are ancient determinants of self-/non-self-recognition. Recent molecular genetic evidence has revealed an allodeterminant in the cnidarian Hydractinia that consistently predicts histocompatibility reactions.
Dishaw
Larry J
LJ
Department of Pediatrics, University of South Florida, 830 First Street South, St. Petersburg, FL 33701, USA.
Litman
Gary W
GW
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D006648:Histocompatibility / Q000235:genetics / Q000276:immunology*; D037402:Hydrozoa / Q000235:genetics / Q000276:immunology*; D008285:Major Histocompatibility Complex; D010641:Phenotype