Unraveling the complexities of androgen receptor signaling in prostate cancer cells.
Androgen signaling is critical for proliferation of prostate cancer cells but cannot be fully inhibited by current androgen deprivation therapies. A study by Xu et al. in this issue of Cancer Cell provides insights into the complexities of androgen signaling in prostate cancer and suggests avenues to target a subset of androgen-sensitive genes.
Heemers
Hannelore V
HV
Department of Urology Research, Mayo Clinic, Rochester, MN 55905, USA.
Tindall
Donald J
DJ
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011944:Receptors, Androgen / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014158:Transcription, Genetic
C410798:AR protein, human; D004268:DNA-Binding Proteins; C119753:RNF6 protein, human; D011944:Receptors, Androgen