Combining two-directional synthesis and tandem reactions: new access to 3,5-disubstituted pyrrolizidines and first total synthesis of alkaloid cis-223B.
Two new tandem reactions for the synthesis of 3,5-disubstituted pyrrolizidines and the first total synthesis of alkaloid cis-223B (in 7 steps and 43% overall yield), involving a double cross metathesis and double Michael addition as key steps, are presented.
Legeay
Jean-Chistophe
JC
School of Chemistry, University of Nottingham, Nottingham, UK NG7 2RD.
Lewis
William
W
Stockman
Robert A
RA
D003500:Cyclization; D008958:Models, Molecular; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry
D011763:Pyrrolizidine Alkaloids