A1/A2 polymorphism of GpIIIa gene and a risk of aneurysmal subarachnoid haemorrhage.
Platelet glycoproteins are involved in pathophysiology of cerebrovascular diseases. The aim of this study was to investigate the association between the GpIIIa gene A1/A2 polymorphism and a risk of aneurysmal subarachnoid haemorrhage (SAH) in a Polish population. In a case-control study we genotyped 288 Caucasian patients with aneurysmal SAH and 457 age-, gender- and race-matched controls. The GpIIIa A1/A2 polymorphism was genotyped with RFLP technique. No difference was found in the distribution of the polymorphism between the cases and controls (cases: A1A1-201 (69.8%), A1A2-83 (28.8%) and A2A2-4 (1.4%) vs. controls: A1A1-323 (70.7%); A1A2-128 (28.0%); A2A2-6 (1.3%), P>0.05. In a multivariate analysis female gender (OR=1.950; 95%CI: 1.308-2.907), hypertension (OR=4.774; 95%CI: 3.048-7.478) and smoking (OR=2.034; 95%CI: 1.366-3.030), but not GpIIIa A1/A2 polymorphism, were independent risk factors for aneurysmal SAH. The GpIIIa A1/A2 polymorphism is not a risk factor of aneurysmal SAH in a Polish population.
Adamski
Mateusz G
MG
Department of Neurology, Jagiellonian University Medical College, Krakow, Poland. adamskimateusz@yahoo.com
Borratynska
Anna
A
Krupa
Mariusz
M
Wloch-Kopec
Dorota
D
Turaj
Wojciech
W
Wolkow
Pawel
P
Wnuk
Marcin
M
Urbanik
Andrzej
A
Moskala
Marek
M
Szczudlik
Andrzej
A
Slowik
Agnieszka
A
D005260:Female; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012306:Risk; D013345:Subarachnoid Hemorrhage / Q000453:epidemiology* / Q000235:genetics*
D039661:Integrin beta3