In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
We tested the effect of probenecid and verapamil in chemosensitizing Plasmodium falciparum to 14 antimalarials using the multidrug-resistant strain V1S and the drug-sensitive 3D7. Verapamil chemosensitizes V1S to quinine and chloroquine. Interestingly, probenecid profoundly chemosensitizes V1S to piperaquine. Thus, probenecid could be used to increase piperaquine efficacy in vivo.
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program, Kiilfi, Kenya.
Victor
V
Masseno
Steven
S
Muriithi
Alexis
A
Nzila
D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011339:Probenecid / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology*
D000277:Adjuvants, Pharmaceutic; D000962:Antimalarials; D014700:Verapamil; D011339:Probenecid