The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis.
This review provides an overview of the inflammatory mechanisms and immunological aspects specific to atopic dermatitis. The review discusses publications on the roles of different T-cell subsets (that is, T helper 1 (Th1), Th2, T-regulatory, and Th17 cells), myeloid and plasmacytoid dendritic cells, and eosinophils. A further focus lies on keratinocyte-T-cell interactions, which may be of particular relevance in eczema. Mechanisms in innate and adaptive immunity that result in susceptibility to skin infections and in hyperreactivity to environmental stimuli, influencing the course and severity of atopic dermatitis, are summarized. Because the Journal of Investigative Dermatology has recently published reviews of specific features of barrier defects, defects in innate immunity, and, in this issue, genetics, these topics are only briefly discussed here in the context of immunology of atopic dermatitis.
Department of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany. werfel.thomas@gmx.de
Thomas
T
Werfel
D000485:Allergens / Q000276:immunology*; D002450:Cell Communication; D016207:Cytokines / Q000502:physiology; D003713:Dendritic Cells / Q000502:physiology; D003876:Dermatitis, Atopic / Q000209:etiology*; D004804:Eosinophils / Q000502:physiology*; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000502:physiology*; D020381:Interleukin-17 / Q000502:physiology; D015603:Keratinocytes / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology
D000485:Allergens; D016207:Cytokines; D020381:Interleukin-17; D007073:Immunoglobulin E