Novel drug-loaded gelatin films and their sustained-release performance.
A new particulate drug delivery system with gelatin matrix containing Ibuprofen as a model drug molecule was developed for an epidermis drug prolonged release. Gelatin films containing Ibuprofen-loaded poly-epsilon-caprolactone (PCL) microspheres have been developed on evaporation of organic solvent from an oil-in-water emulsion followed by cross-linking. The microspheres were characterized for particle size, encapsulation efficiency, and surface morphology. Water uptake, matrix erosion, and drug release profile of the microsphere-film system were investigated. The results indicated that drug-loaded microspheres introduced in this system successfully prolonged drug release time. This kind of microsphere-film system combined good adhesion, typical for gelatin films, with the sustained release performance of PCL microspheres.
Lin
Mei
M
Department of Macromolecular Science, Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Fudan University, Shanghai 200433, China.
Meng
Sheng
S
Zhong
Wei
W
Cai
Rui
R
Du
Qiangguo
Q
Tomasik
Piotr
P
D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005780:Gelatin / Q000737:chemistry*; D006868:Hydrolysis; D007052:Ibuprofen / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D014867:Water / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D012997:Solvents; D014867:Water; C016240:polycaprolactone; D005780:Gelatin; D007052:Ibuprofen