[A case of IL-6 producing malignant mesothelioma of abdomen with thrombocytosis].
A 77-year-old man was admitted to our hospital with abdominal pain and ascites. He had an occupational history of working with asbestos. Abdominal CT showed multiple nodular lesions with enhancement by contrast medium in the cavity. Platelet counts, CRP and serum IL-6 level were increased. Biopsied materials obtained by laparoscopy showed oval cells with rich cytoplasm growing in an epithelial pattern. To clarify the characteristics of the cells, immunohistochemistry was performed. Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma. Because IL-6, IL-6 receptor and VEGF were expressed markedly, the patient received chemotherapy for IL-6 suppression. During the treatment, thrombocytosis imploved satisfactorily.
Fukuyama
Tomoki
T
Department of Gastroenterology, Kanazawa Medical University, Japan. t-fukky@kanazawa-med.ac.jp
Kawahara
Hiromu
H
Yamada
Masayoshi
M
Hayashi
Nobuhiko
N
Yano
Hirokazu
H
Fukura
Masayuki
M
Ozaki
Kazuaki
K
Tsuchishima
Mutsumi
M
Takase
Shujiro
S
Arisawa
Tomiyasu
T
Omote
Kazuhiko
K
Nojima
Takayuki
T
D000008:Abdominal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D000368:Aged; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D008654:Mesothelioma / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D013922:Thrombocytosis / Q000150:complications
D015850:Interleukin-6