Antiplasmodial halogenated monoterpenes from the marine red alga Plocamium cornutum.
In our continuing search for antimalarial leads from South African marine organisms we have examined the antiplasmodial organic extracts of the endemic marine red alga Plocamium cornutum (Turner) Harvey. Two new and three known halogenated monoterpenes were isolated and their structures determined by standard spectroscopic techniques. The 3,7-dimethyl-3,4-dichloro-octa-1,5,7-triene skeleton is common to all five compounds. Interestingly, compounds bearing the 7-dichloromethyl substituent showed significantly higher antiplasmodial activity toward a chloroquine sensitive strain of Plasmodium falciparum.
Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Artillery Road, Grahamstown 6140, South Africa.
Anthonia F
AF
Afolayan
Maryssa G A
MG
Mann
Carmen A
CA
Lategan
Peter J
PJ
Smith
John J
JJ
Bolton
Denzil R
DR
Beukes
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006219:Halogens / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D044725:Plocamium / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D000962:Antimalarials; D006219:Halogens; D039821:Monoterpenes; D010936:Plant Extracts