Frequency of CYP1A2 polymorphism in beagle dogs.
A single nucleotide polymorphism in the dog CYP1A2 gene causes these animals to be CYP1A2 deficient (i.e., lack functional CYP1A2 enzyme activity). Genotyping a colony of 79 dogs revealed 77% wild-type, 19% heterozygous, and 4% homozygous mutant animals. These genetic frequencies are significantly different from those previously reported and illustrate that different sources and populations of dogs can have dramatically different frequencies of this polymorphism.
Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Company, Wallingford, CT 06492, USA. valerie.whiterock@bms.com
Valerie J
VJ
Whiterock
Terrye A
TA
Delmonte
Lester E
LE
Hui
Tami L
TL
Orcutt
Michael W
MW
Sinz
D000818:Animals; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D004285:Dogs; D005260:Female; D005787:Gene Frequency; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D009154:Mutation; D020641:Polymorphism, Single Nucleotide
D019388:Cytochrome P-450 CYP1A2