Recent developments in anti-inflammatory natural products.
Many of the inflammatory diseases are becoming common in aging society throughout the world. The clinically used anti-inflammatory drugs suffer from the disadvantage of side effects and high cost of treatment (in case of biologics). Alternative to these drugs are traditional medicines and natural products, which offer a great hope in the identification of bioactive lead compounds and their development into drugs for treating inflammatory diseases. Since ancient times traditional medicines and phytopharmaceuticals are being used for the treatment of inflammatory and other disorders. The present review article describes anti-inflammatory natural products derived from plants and marine sources reported during last decade. The compounds described belong to different chemical classes such as alkaloids, steroids, terpenoids, polyphenolics, phenylpropanoids, fatty acids and lipids, and various miscellaneous compounds. The attempt is also being made to enumerate the possible leads, e.g. curcumin, resveratrol, baicalein, boswellic acid, betulinic acid, ursolic acid, and oleanolic acid, for further development with the help of structure-activity relationship (SAR) studies and their current status. In addition SAR studies carried out on the anti-inflammatory activity of flavonoid compounds and clinical studies performed on anti-inflammatory natural products are also discussed.
Gautam
Raju
R
Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S Nagar, Mohali-160 062, Punjab, India.
Jachak
Sanjay M
SM
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*; D006801:Humans; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D001688:Biological Products