In vivo and in vitro study of papaverine and its major metabolites.
Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei University, Wuhan 430062, China.
Zhi-hong
ZH
Peng
Wei
W
Song
Feng-mei
FM
Han
Yong
Y
Chen
D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010208:Papaverine / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics
D014665:Vasodilator Agents; D010208:Papaverine