Reduced intradermal test dose of yellow fever vaccine induces protective immunity in individuals with egg allergy.
The neutralising antibody response after the yellow fever vaccine (YF-17D) skin test was measured in 7 egg allergic persons in whom further vaccination was abandoned because of a strong local urticarial reaction to the YF-17D vaccine test dose. We found that this test dose of 0.1mL of YF-17D vaccine was sufficient to induce a protective antibody response in all 7 subjects. Intradermal injection of 1/5th dose of the yellow fever vaccine appears to be sufficient, in non-allergic as well as allergic persons, and non-inferior to the subcutaneous full dose.
Dept. of Infectious Diseases, Leiden University Medical Center, The Netherlands. A.H.E.Roukens@lumc.nl
Anna H
AH
Roukens
Ann C
AC
Vossen
Jaap T
JT
van Dissel
Leo G
LG
Visser
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D021181:Egg Hypersensitivity / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D007271:Injections, Intradermal; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D022341:Yellow Fever Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
D000914:Antibodies, Viral; D022341:Yellow Fever Vaccine