IgE-mediated fungal allergy in allergic fungal sinusitis.
This review will address the current knowledge of the pathogenic mechanisms in allergic fungal sinusitis (AFS) and the basis for the current classification of a subgroup of chronic rhinosinusitis patients. Special attention is directed to the role of immunoglobulin E (IgE)-mediated fungal allergy in the pathogenesis of AFS. Concepts relating to the mucosal inflammatory response are introduced, as a knowledge of the reactions of the sinus mucosal cells can lead to a better understanding of the mechanisms perpetuating and maintaining the chronic inflammation. Laryngoscope, 2009.
Department of Otorhinolaryngology Head and Neck Surgery, the University of Adelaide, Adelaide, Australia. panth@upmc.edu
Harshita
H
Pant
Mark A
MA
Schembri
Peter J
PJ
Wormald
Peter J
PJ
Macardle
D002908:Chronic Disease; D004802:Eosinophilia / Q000175:diagnosis / Q000276:immunology*; D005658:Fungi / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood*; D009092:Mucous Membrane / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000276:immunology*; D012852:Sinusitis / Q000175:diagnosis / Q000276:immunology*
D007073:Immunoglobulin E