[ATP-sensitive potassium channel and its cardiovascular protection effects].
ATP-sensitive potassium channel(K(ATP)) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor, which is an ATP-binding cassette transporter. K(ATP) has been indentified in a variety of tissues and recognized as an important drug target. It connects cell metabolism with cell electric activity. K(ATP) has been proposed to play protective roles during heart failure, arrhythmia, myocardial infarction, stress, myocardial ischemia and hypertension. In this review, a summary of K(ATP) is presented with molecular structure, localization, regulation, cardiovascular protective effect and its mechanisms.
Zhang
Rong-yuan
RY
Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Jin
Hong-fang
HF
Tang
Chao-shu
CS
DU
Jun-bao
JB
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000502:physiology; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D054086:KATP Channels / Q000737:chemistry* / Q000502:physiology*; D024661:Potassium Channels, Inwardly Rectifying / Q000737:chemistry / Q000502:physiology; D011955:Receptors, Drug / Q000737:chemistry / Q000502:physiology; D064233:Sulfonylurea Receptors
D018528:ATP-Binding Cassette Transporters; D054086:KATP Channels; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug; D064233:Sulfonylurea Receptors; C092520:uK-ATP-1 potassium channel