[Application of numerical convolution in in vivo/in vitro correlation research].
This paper introduced the conception and principle of in vivo/in vitro correlation (IVIVC) and convolution/deconvolution methods, and elucidated in details the convolution strategy and method for calculating the in vivo absorption performance of the pharmaceutics according to the their pharmacokinetic data in Excel, then put the results forward to IVIVC research. Firstly, the pharmacokinetic data ware fitted by mathematical software to make up the lost points. Secondly, the parameters of the optimal fitted input function were defined by trail-and-error method according to the convolution principle in Excel under the hypothesis that all the input functions fit the Weibull functions. Finally, the IVIVC between in vivo input function and the in vitro dissolution was studied. In the examples, not only the application of this method was demonstrated in details but also its simplicity and effectiveness were proved by comparing with the compartment model method and deconvolution method. It showed to be a powerful tool for IVIVC research.
Yue
Peng
P
Shanghai Huayi Bio-Lab Co. Ltd, Shanghai 200235, China. ypsucker@hotmail.com
D000042:Absorption; D000465:Algorithms; D000818:Animals; D044182:Benzylisoquinolines / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D008433:Mathematics; D008687:Metformin / Q000493:pharmacokinetics*; D008954:Models, Biological; D012984:Software; D012995:Solubility
D044182:Benzylisoquinolines; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; C009438:tetrandrine; D008687:Metformin