Disruption of Chrysomya megacephala growth caused by lignan grandisin.
The toxicity of tetrahydrofuran lignan grandisin was evaluated against larvae of Chrysomya megacephala F. (Diptera: Calliphoridae). The bioassay involved topical treatment on larvae, topical treatment on egg masses, and incorporation in the larval diet. Grandisin showed inhibition of postembryonic development by ovicidal (30%) and larvicidal (38%) effects and reduced larval weight (4 mg), when topically applied on egg masses and starving larvae (L1) at a concentration of 100 microg/microl. These findings elucidated the effect of grandisin on the C. megacephala life cycle and its potential to control C. megacephala populations.
Laboratório de Diptera/Entomologia/IOC, Fundação Oswaldo Cruz, Av. Brasil 4365, 21040-900 Rio de Janeiro, RJ, Brazil.
Camila Diniz Ribeiro
CD
Nogueira
Rubens Pinto
RP
de Mello
Massuo Jorge
MJ
Kato
Marise Maleck de Oliveira
MM
Cabral
D000818:Animals; D004175:Diptera / Q000187:drug effects* / Q000254:growth & development; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology*; D007300:Insect Control; D007306:Insecticides / Q000302:isolation & purification*; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D008675:Metamorphosis, Biological / Q000187:drug effects*; D031701:Piper / Q000737:chemistry*; D018675:Toxicity Tests
D005663:Furans; D007306:Insecticides; D017705:Lignans; C074346:grandisin