Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases.
The NADPH oxidase (Nox) enzyme family generates reactive oxygen species (ROS) that contribute to cell signaling, innate immune responses, proliferation, and transcription. The signaling mechanisms that regulate this important enzyme family are only beginning to be understood. Evidence is emerging which suggests that phosphorylation of Nox and/or their regulatory components may be important means of modulating their activity. We describe here the evidence for Nox regulation through the action of kinases, and speculate on how such regulatory mechanisms might contribute to the development of pathological disease states.
Bokoch
Gary M
GM
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA. Bokoch@scripps.edu
Diebold
Becky
B
Kim
Jun-Sub
JS
Gianni
Davide
D
D048948:14-3-3 Proteins / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D019255:NADPH Oxidases / Q000378:metabolism*; D010586:Phagocytes / Q000201:enzymology; D010766:Phosphorylation; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D020744:rac GTP-Binding Proteins / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism
D048948:14-3-3 Proteins; D007527:Isoenzymes; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases; D019061:src-Family Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D020744:rac GTP-Binding Proteins