Stress-induced dendritic remodeling in the medial prefrontal cortex: effects of circuit, hormones and rest.
The medial prefrontal cortex (mPFC) has been implicated as a site of dysfunction and abnormal morphology in major depressive disorder and post-traumatic stress disorder, two illnesses that can be brought on by exposure to stress. In animal models, stress has long been shown to induce impairments in tasks known to be mediated by the mPFC, and recent work has demonstrated that chronic stress can lead to morphological changes in mPFC pyramidal cells. This review explores the current literature on stress-induced dendritic remodeling in the mPFC, with particular focus on new findings that illuminate modulators of these effects.
Shansky
Rebecca M
RM
Department of Neuroscience, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. shansky@gmail.com
Morrison
John H
JH
D000818:Animals; D003712:Dendrites / Q000378:metabolism / Q000473:pathology*; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000473:pathology; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000473:pathology; D017397:Prefrontal Cortex / Q000378:metabolism / Q000473:pathology*; D013315:Stress, Psychological / Q000378:metabolism / Q000473:pathology*
D004967:Estrogens