Frequency and spatial distribution of thin-cap fibroatheroma assessed by 3-vessel intravascular ultrasound and optical coherence tomography: an ex vivo validation and an initial in vivo feasibility study.
BACKGROUND
The precursor of plaque rupture is known as thin cap fibroatheroma (TCFA). In the present study, the feasibility and accuracy of optical coherence tomography (OCT) for detecting the frequency and spatial distribution of TCFA was investigated ex vivo, and a 3-vessel OCT analysis was conducted to assess the feasibility of this modality in vivo.


RESULTS
In the ex vivo study, 108 coronary arterial segments from 38 human cadavers were examined by OCT, intravascular ultrasound (IVUS) and histology. The 3-vessel IVUS and OCT examinations were performed in 11 patients with acute coronary syndrome. By histological examination, 30 of 77 fibroatheromas were diagnosed as TCFAs, which showed a clear pattern of clustering in the proximal part of each coronary vessel. OCT accurately detected TCFA (sensitivity 90%, specificity 79%). The in vivo OCT study showed that 64% patients with acute coronary syndrome had 1 or more TCFAs.


CONCLUSIONS
TCFAs, clustering in the proximal segments of the 3 major epicardial coronary arteries, are a common finding in unselected autopsy subjects. OCT is a feasible and accurate modality for detecting TCFA both ex vivo and in vivo.
Department of Cardiology, Kawasaki Medical School, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Teruyoshi
T
Kume
Hiroyuki
H
Okura
Ryotaro
R
Yamada
Takahiro
T
Kawamoto
Nozomi
N
Watanabe
Yoji
Y
Neishi
Yoshito
Y
Sadahira
Takashi
T
Akasaka
Kiyoshi
K
Yoshida
D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods*