Mutations in the JAK2 and MPL genes and their correlation to clinical parameters in patients with chronic myeloproliferative disease.
BACKGROUND
The objective of this study was to correlate the V617F mutation of the JAK2gene and the W515 mutation of the MPLgene in patients with chronic myeloproliferative disease (CMPD) with clinical parameters.


METHODS
51 patients were analyzed: 31 with essential thrombocythemia (ET), 20 with polycythemia vera (PV) and 2 with primary myelofibrosis (PMF). 1 patient had unclassifiable CMPD (CMPD-U). 3 patients had overlapping features of ET and PV.


RESULTS
31 patients (14 with PV, 19 with ET, 3 with concomitant ET and PV, and 1 with PMF) showed the JAK2mutation, and 2 patients with ET the W515 mutation. There were no significant differences in hematocrit at diagnosis in JAK2-nonmutated versus -mutated patients with PV. Also, patients with ET had comparable platelet counts at diagnosis. The mean time from diagnosis to initiation of first therapy was similar for all patients with non-mutated versus mutated JAK2. Patients with ET and mutated JAK2were significantly older at diagnosis than those with the wildtype gene (65.5 years vs. 54.4 years; p = 0.016).


CONCLUSIONS
JAK2V617F or MPLW515 mutations do not seem to correlate with simple clinical parameters. ET patients with wild-type JAK2were significantly younger at diagnosis.
Bojko
Peter
P
Munich Oncology Practice, MVZ Elisenhof, Munich, Germany. p.bojko@onkologie-elisenhof.de
Abenhardt
Wolfgang
W
Schnittger
Susanne
S
Haferlach
Torsten
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000235:genetics*; D053628:Receptors, Thrombopoietin / Q000235:genetics*; D013223:Statistics as Topic
D053628:Receptors, Thrombopoietin; C082218:MPL protein, human; C507924:JAK2 protein, human; D053614:Janus Kinase 2