Expression, purification, and crystallization of Toll/interleukin-1 receptor (TIR) domains.
Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) play crucial roles in host innate immune response against microbial infections. These receptors share a conserved cytoplasmic domain, the Toll/interleukin-1 receptor (TIR) domain, which is required for signaling through these receptors. Structural information on the TIR domains will be essential for understanding the molecular basis for signal transduction by these receptors.
Tao
Xiao
X
Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Tong
Liang
L
D003460:Crystallization; D015870:Gene Expression; D006801:Humans; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D017472:Receptors, Interleukin-1 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*
D017472:Receptors, Interleukin-1; D051193:Toll-Like Receptors