Tbx18 and the fate of epicardial progenitors.
Uncovering the origins of myocardial cells is important for understanding and treating heart diseases. Cai et al. suggest that Tbx18-expressing epicardium provides a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Here we show that the T-box transcription factor gene 18 (Tbx18) itself is expressed in the myocardium, showing that their genetic lineage tracing system does not allow conclusions of an epicardial origin of cardiomyocytes in vivo to be drawn.
Department of Anatomy & Embryology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15 L2-108, 1105 AZ Amsterdam, The Netherlands.
Vincent M
VM
Christoffels
Thomas
T
Grieskamp
Julia
J
Norden
Mathilda T M
MT
Mommersteeg
Carsten
C
Rudat
Andreas
A
Kispert
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D005456:Fluorescent Dyes; D018507:Gene Expression Regulation, Developmental; D055879:Gene Knock-In Techniques; D006352:Heart Ventricles / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D017403:In Situ Hybridization; D019426:Integrases / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009206:Myocardium / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism; D010496:Pericardium / Q000166:cytology* / Q000196:embryology; D012313:RNA / Q000032:analysis / Q000235:genetics; D015203:Reproducibility of Results; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism*
D005456:Fluorescent Dyes; D020825:T-Box Domain Proteins; C420983:Tbx18 protein, mouse; D012313:RNA; C045073:Cre recombinase; D019426:Integrases