Serum resistin concentrations and risk of new onset heart failure in older persons: the health, aging, and body composition (Health ABC) study.
OBJECTIVE
Resistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction. We investigated the association of serum resistin concentrations with risk for incident heart failure (HF) in humans.


RESULTS
We studied 2902 older persons without prevalent HF (age, 73.6+/-2.9 years; 48.1% men; 58.8% white) enrolled in the Health, Aging, and Body Composition (Health ABC) Study. Correlation between baseline serum resistin concentrations (20.3+/-10.0 ng/mL) and clinical variables, biochemistry panel, markers of inflammation and insulin resistance, adipocytokines, and measures of adiposity was weak (all rho <0.25). During a median follow-up of 9.4 years, 341 participants (11.8%) developed HF. Resistin was strongly associated with risk for incident HF in Cox proportional hazards models controlling for clinical variables, biomarkers, and measures of adiposity (HR, 1.15 per 10.0 ng/mL in adjusted model; 95% CI, 1.05 to 1.27; P=0.003). Results were comparable across sex, race, diabetes mellitus, and prevalent and incident coronary heart disease subgroups. In participants with available left ventricular ejection fraction at HF diagnosis (265 of 341; 77.7%), association of resistin with HF risk was comparable for cases with reduced versus preserved ejection fraction.


CONCLUSIONS
Serum resistin concentrations are independently associated with risk for incident HF in older persons.
Butler
Javed
J
Emory University, Atlanta Ga., USA. javed.butler@emory.edu
Kalogeropoulos
Andreas
A
Georgiopoulou
Vasiliki
V
de Rekeneire
Nathalie
N
Rodondi
Nicolas
N
Smith
Andrew L
AL
Hoffmann
Udo
U
Kanaya
Alka
A
Newman
Anne B
AB
Kritchevsky
Stephen B
SB
Vasan
Ramachandran S
RS
Wilson
Peter W F
PW
Harris
Tamara B
TB
D001741:Black or African American; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male; D016016:Proportional Hazards Models; D052243:Resistin / Q000097:blood*; D012306:Risk; D018487:Ventricular Dysfunction, Left / Q000097:blood; D016277:Ventricular Function, Left; D044465:White People
D015415:Biomarkers; D052243:Resistin