Settling the thymus: immigration requirements.
Thymus settling by precursor cells is essential for the production of T cells, yet the immigration requirements are poorly defined. P-selectin and CC chemokine receptor-9 (CCR9) are involved, and settling is favored when existing residents have moved on. A new study strengthens the correlation between niche emptying and the induction of thymic P-selectin and CCR9 ligand, and provides evidence for feedback from the periphery to thymic P-selectin expression via sphingosine-1-phosphate.
Jason G
JG
Cyster
D000075906:Chemokine CCL26; D019742:Chemokines, CC / Q000276:immunology; D006801:Humans; D018448:Models, Immunological; D019007:P-Selectin / Q000502:physiology; D054388:Receptors, CCR / Q000276:immunology; D019707:Receptors, Chemokine / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology / Q000502:physiology*
C119309:CC chemokine receptor 9; C120429:CCL26 protein, human; D000075906:Chemokine CCL26; D019742:Chemokines, CC; D019007:P-Selectin; D054388:Receptors, CCR; D019707:Receptors, Chemokine