Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties.
The synthesis of a new series of oxazolidinones having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the oxazolidinone ring was investigated. A particular compound Ih having fluoro group showed the most potent antibacterial activity.
Life Sciences Research Division, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea.
So-Young
SY
Kim
Hyeong Beom
HB
Park
Jung-Hyuck
JH
Cho
Kyung Ho
KH
Yoo
Chang-Hyun
CH
Oh
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000378:metabolism; D006536:Heptanes / Q000737:chemistry; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D006536:Heptanes; D023303:Oxazolidinones; D014640:Vancomycin; D008712:Methicillin