Circadian biology: an unexpected invitee to new time zones.
Adaptation to changing light conditions is a hallmark of the circadian clock. A new study points to the critical role played by a transcriptional repressor previously implicated in cell differentiation, highlighting unappreciated links between the clock and the control of development and tumorigenesis.
Masubuchi
Satoru
S
Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA.
Sassone-Corsi
Paolo
P
D056930:ARNTL Transcription Factors; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D001522:Behavior, Animal / Q000502:physiology; D001683:Biological Clocks / Q000502:physiology*; D056926:CLOCK Proteins; D002940:Circadian Rhythm / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D051797:Inhibitor of Differentiation Protein 2 / Q000235:genetics / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D056950:Period Circadian Proteins; D013997:Time Factors; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism
D056930:ARNTL Transcription Factors; D051792:Basic Helix-Loop-Helix Proteins; D056926:CLOCK Proteins; D051797:Inhibitor of Differentiation Protein 2; D047908:Intracellular Signaling Peptides and Proteins; D056950:Period Circadian Proteins; D015534:Trans-Activators; C538960:BMAL1 protein, human; C538961:Bmal1 protein, mouse; C497452:Idb2 protein, mouse; C539022:PER1 protein, human; C539023:Per1 protein, mouse; C538943:CLOCK protein, human; C538944:Clock protein, mouse