Pomegranate fruit components modulate human thrombin.
Pomegranate (Punica granatum) is an important source of polyphenols with assessed antioxidant properties. The aims of this study were: (i) the characterization of the monomeric phenolic variability on each isolated fruit component (endocarp, mesocarp, aril); (ii) the study on the effect of pomegranate fruit components on human thrombin amidolytic activity. Collectively, our data show that pomegranate components contain bioactive metabolites (mainly ellagic acid) and suggest a potential role for the pomegranate extract in the regulation of a number of physio-pathological processes involving thrombin (or thrombin-like proteinase).
Cuccioloni
M
M
Department of Molecular, Cellular & Animal Biology, University of Camerino, Italy.
Mozzicafreddo
M
M
Sparapani
L
L
Spina
M
M
Eleuteri
A M
AM
Fioretti
E
E
Angeletti
M
M
D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit; D006801:Humans; D029561:Lythraceae / Q000737:chemistry*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013917:Thrombin / Q000037:antagonists & inhibitors*
D000975:Antioxidants; D010636:Phenols; D010936:Plant Extracts; D013917:Thrombin