Aryloxypyrazines as highly selective antagonists of Oxytocin.
A series of aryloxypyrazines were designed based on structural overlap with previously reported arylpyrazine Oxytocin antagonists. Similarly high levels of Oxytocin antagonism were achievable in this new series. In addition, significant improvements in selectivity over the related vasopressin V(1A) receptor were also possible.
Discovery Chemistry, Pfizer Global Research and Development, Sandwich, United Kingdom. Alan.D.Brown@pfizer.com
Alan
A
Brown
Dave
D
Ellis
David
D
Pearce
Michael
M
Ralph
Nunzio
N
Sciammetta
D065092:Antidiuretic Hormone Receptor Antagonists; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry*
D065092:Antidiuretic Hormone Receptor Antagonists; D011719:Pyrazines; D010121:Oxytocin