Four spatial points that define enzyme families.
The catalytic properties of enzymes, containing the Asp-His-Ser triads are deeply investigated for a long time. Serine endopeptidases, cutinases, acetylcholinesterases, cellulases, among other enzymes, contain these triads. We found that solely the geometric properties of just four points in the spatial structure of these enzymes are characteristic to their family.
Iván
Gábor
G
Protein Information Technology Group, Eötvös University, 1117 Budapest, Hungary.
Szabadka
Zoltán
Z
Ordög
Rafael
R
Grolmusz
Vince
V
Náray-Szabó
Gábor
G
D000595:Amino Acid Sequence; D001224:Aspartic Acid / Q000737:chemistry*; D002384:Catalysis; D030562:Databases, Protein; D004798:Enzymes / Q000737:chemistry* / Q000145:classification*; D006639:Histidine / Q000737:chemistry*; D011487:Protein Conformation; D012694:Serine / Q000737:chemistry*
D004798:Enzymes; D001224:Aspartic Acid; D012694:Serine; D006639:Histidine