Determination of boron distribution in rat's brain, kidney and liver.
To determine relative boron distribution in rat's brain, liver and kidney, a mixture of boric acid and borax, was used. After transcardial injection of the solution, the animals were sacrificed and the brain, kidney and liver were removed. The coronal sections of certain areas of the brain were prepared by freezing microtome. The slices were sandwiched within two pieces of CR-39. The samples were bombarded in a thermal neutron field of the TRR pneumatic facility. The alpha tracks are registered on CR-39 after being etched in NaOH. The boron distribution was determined by counting these alpha tracks CR-39 plastics. The distribution showed non-uniformity in brain, liver and kidney.
Nuclear Engineering Department, Science and Research Branch, Islamic Azad University, Tehran, Iran. paziran@khayam.ut.ac.ir
Ali
A
Pazirandeh
Behnam
B
Jameie
Maysam
M
Zargar
D000512:Alpha Particles; D000818:Animals; D001895:Boron / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects; D001932:Brain Neoplasms / Q000378:metabolism / Q000532:radiotherapy; D006801:Humans; D007554:Isotopes / Q000493:pharmacokinetics / Q000627:therapeutic use; D007668:Kidney / Q000378:metabolism* / Q000528:radiation effects; D008099:Liver / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D011874:Radiometry; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D007554:Isotopes; D011838:Radiation-Sensitizing Agents; D001895:Boron