HLA class I and II alleles and response to treatment with interferon-beta in relapsing-remitting multiple sclerosis.
In the present study, we investigated the influence of HLA class I and class II genes in the response to interferon-beta (IFNbeta) in multiple sclerosis (MS) patients. HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 DNA typing was performed by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) in a cohort of 149 relapsing-remitting MS patients classified into IFNbeta responders (n=74) and non-responders (n=75) based on stringent clinical criteria. Distribution of HLA class I and class II alleles individually and the HLA-DR2 haplotype was similar between responders and non-responders to treatment. These findings do not support a role of the HLA class I and class II genes as modifiers of the response to IFNbeta.
Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Autonoma de Barcelona [corrected] Barcelona, Spain. mcomabel@ir.vhebron.net
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D000328:Adult; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D004351:Drug Resistance / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000097:blood / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000097:blood / Q000235:genetics*; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage; D016899:Interferon-beta / Q000008:administration & dosage*; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000188:drug therapy* / Q000235:genetics*; D011237:Predictive Value of Tests
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D007155:Immunologic Factors; D016899:Interferon-beta