Inhibition of selenium metabolism in the oral pathogen Treponema denticola.
In this report we provide evidence that the antimicrobial action of stannous salts and a gold drug, auranofin, against Treponema denticola is mediated through inhibition of the metabolism of selenium for synthesis of selenoproteins.
Jackson-Rosario
Sarah
S
Department of Molecular Biology and Microbiology, Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL 32816-2364, USA.
Self
William T
WT
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001310:Auranofin / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism; D015536:Down-Regulation; D006801:Humans; D009059:Mouth Diseases / Q000382:microbiology*; D012643:Selenium / Q000378:metabolism*; D051140:Selenoproteins / Q000378:metabolism; D017971:Tin Compounds / Q000494:pharmacology; D048373:Treponema denticola / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D014211:Treponemal Infections / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D051140:Selenoproteins; D017971:Tin Compounds; D001310:Auranofin; D012643:Selenium