Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer.
BACKGROUND
The aim of this study was to evaluate the relations of SDF-1 and its receptor, CXCR4, gene variants on oral cancer risk.


METHODS
PCR-RFLP was used to measure SDF-1-3'A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer.


RESULTS
After being adjusted for age, individuals with A/G heterozygotes of SDF-1 had a higher risk of 1.86-fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66-fold to progress to stage III or IV.


CONCLUSIONS
SDF-1-3'A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese.
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Ying-Hock
YH
Teng
Te-Hsiung
TH
Liu
Hsien-Chun
HC
Tseng
Tsung-Te
TT
Chung
Chia-Ming
CM
Yeh
Yu-Chiung
YC
Li
Yu-Hsiang
YH
Ou
Long-Yau
LY
Lin
Hsiu-Ting
HT
Tsai
Shun-Fa
SF
Yang
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002454:Cell Differentiation; D054377:Chemokine CXCL12 / Q000235:genetics*; D004587:Electrophoresis, Agar Gel; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D019718:Receptors, CXCR4 / Q000235:genetics*
C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; D019718:Receptors, CXCR4