Lympidem (a coumarin derivative) induced reversible hepatotoxicity in an adult Sri Lankan.
Lympidem is a coumarin derivative which is advocated for treatment of mainly chronic lymphedema by the manufacturer. Since its introduction there had been several reports with regard to coumarin-induced hepatotoxicity from Europe. We report an adult Sri Lankan middle-aged female who presented with abnormal liver functions due to Lympidem, which resulted in discontinuation of the drug, while no other etiology could be found. To the best of our knowledge, this is the first reported case from South East Asia. We recommend monitoring of liver functions while on coumarin therapy to prevent irreversible damage.
Satarasinghe
R L
RL
Department of Medicine, Sri Jayewardenepura General Hospital and Postgraduate Training Center, Thalapathpitiya, Nugegoda, Sri Lanka.
Jayawardana
M A R
MA
D056486:Chemical and Drug Induced Liver Injury; D003374:Coumarins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D035002:Lower Extremity; D008209:Lymphedema / Q000188:drug therapy; D008875:Middle Aged
D003374:Coumarins; C030123:coumarin