Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population.
Despite extensive exploration of many genes, strong evidence of a molecular genetic association with coronary heart disease (CHD) or myocardial infarction (MI) remains to be obtained. Recently, significant interest has emerged in mapping genetic susceptibility for complex traits through whole-genome studies association generating promoting data that will determine the genetic contribution to common human diseases such as coronary heart disease. The aim of the present case-control study including 324 healthy controls and 296 patients with coronary heart disease from Tunisia, was to assess relation between three polymorphisms previously reported to be strongly associated with coronary heart disease in the Welcome Trust Case Control Consortium (WTCCC) and the German myocardial infarction family studies: locus 9p21.3 (rs 1333049), locus 6q25.1 (rs6922269) and 2q36.3 (rs2943634). By single locus analysis, no differences in genotype distribution and allelic frequency were found between the two groups of study. The risk allele (C) for rs2943634 was less frequent among Tunisian population than in controls from the WTCCC and German studies (57% vs 65%). The three SNPs previously reported to be associated with CHD were not replicated in our small sample.
Faculty of Pharmacy of Monastir, Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Monastir, 5000, Tunisia.
Lakhdar
L
Ghazouani
Sonia Ben Hadj
SB
Khalifa
Nesrine
N
Abboud
Claire
C
Perret
Viviane
V
Nicaud
Ali
A
Ben Khalfallah
Wassim Youssef
WY
Alamawi
François
F
Cambien
Touhami
T
Mahjoub
D000368:Aged; D000619:Aminohydrolases / Q000235:genetics*; D016022:Case-Control Studies; D002889:Chromosomes, Human, Pair 2; D002899:Chromosomes, Human, Pair 9; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005574:Formate-Tetrahydrofolate Ligase / Q000235:genetics*; D016678:Genome; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000235:genetics*; D008875:Middle Aged; D009097:Multienzyme Complexes / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014416:Tunisia
D009097:Multienzyme Complexes; C021836:formyl-methenyl-methylenetetrahydrofolate synthetase; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D000619:Aminohydrolases; D005574:Formate-Tetrahydrofolate Ligase