Subsecond reward-related dopamine release in the mouse dorsal striatum.
Reward presentation is known to induce transient bursts of midbrain dopamine neurons in monkeys and rats, and the reward-induced dopamine overflow has been detected in the rat ventral striatum. To detect reward-related dopamine release in the dorsal striatum of behaving mice (C57BL/6), we used voltammetry with carbon-fiber microelectrodes implanted into the dorsal striatum. Dopamine signals increased transiently after food delivery with a peak at 0.6 s after the delivery onset. The success in detecting transient reward-response of dopamine in behaving mice opens a wide range of application to studies in mutant mice.
Natori
Shihoko
S
Department of Neurophysiology, Juntendo University School of Medicine, Tokyo, Japan.
Yoshimi
Kenji
K
Takahashi
Toshimitsu
T
Kagohashi
Maki
M
Oyama
Genko
G
Shimo
Yasushi
Y
Hattori
Nobutaka
N
Kitazawa
Shigeru
S
D000818:Animals; D001522:Behavior, Animal; D001703:Biophysics; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation / Q000379:methods; D004563:Electrochemistry / Q000379:methods; D005247:Feeding Behavior; D005502:Food; D005508:Food Deprivation / Q000502:physiology; D005518:Food Preferences; D005829:Geniculate Bodies / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008839:Microelectrodes; D011930:Reaction Time / Q000502:physiology*; D012201:Reward
D004298:Dopamine