Novel mechanisms of HIV protease inhibitor resistance.
OBJECTIVE
Several alternative mechanisms that cause protease inhibitor resistance have been proposed. A summary of the proposed mechanisms and the status regarding their clinical relevance is given.


RESULTS
At this moment only changes in the cleavage sites of protease (either alone or in the background of protease mutations) have been associated with phenotypic changes in IC50 and virological failure.


CONCLUSIONS
Further studies are necessary to unravel the mechanism, the clinical relevance and potential effect of transmission of these cleavage site changes.
Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Monique
M
Nijhuis
Noortje M
NM
van Maarseveen
Jens
J
Verheyen
Charles Ab
CA
Boucher