Allele distribution and effect on reporter gene expression of vasopressin receptor gene (AVPR1a)-linked VNTR in primates.
We surveyed repeat sequence in the 5' flanking region of primate arginine vasopressin receptor 1a gene (AVPR1a) which is important for social behavior in mammals. The amplified region was polymorphic in length in all species investigated. In addition, length variants were examined for promoter activity by in vitro expression of the luciferase gene. However, no significant difference was observed. This region could be a marker to further survey functional difference between and within species.
The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan.
Kyung-Won
KW
Hong
Ryota
R
Matsukawa
Yoko
Y
Hirata
Ikuo
I
Hayasaka
Yuichi
Y
Murayama
Shin'ichi
S
Ito
Miho
M
Inoue-Murayama
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D001522:Behavior, Animal / Q000502:physiology; D019556:COS Cells; D002522:Chlorocebus aethiops; D019143:Evolution, Molecular; D005786:Gene Expression Regulation / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D017930:Genes, Reporter / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008156:Luciferases; D018598:Minisatellite Repeats / Q000235:genetics*; D008967:Molecular Biology / Q000379:methods; D016716:PC12 Cells; D010802:Phylogeny; D011110:Polymorphism, Genetic / Q000235:genetics; D011323:Primates / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D017483:Receptors, Vasopressin / Q000235:genetics*; D012919:Social Behavior
D005819:Genetic Markers; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; D008156:Luciferases