Mirtazapine in an HIV-1 infected patient with progressive multifocal leukoencephalopathy.
We describe the clinical course of an HIV-infected patient with progressive multifocal leukoencephalopathy who took mirtazapine for his depression. After six months of therapy the clinical symptoms had not worsened and the neuroradiological image of the brain was unchanged. Further studies are necessary to determine the effect of serotonin receptor antagonist in treating PML associated to HIV.
Lanzafame
M
M
Unit of Infectious Diseases, University of Verona, Ospedale Policlinico,Verona, Italy.
Ferrari
S
S
Lattuada
E
E
Corsini
F
F
Deganello
R
R
Vento
S
S
Concia
E
E
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D023241:Antiretroviral Therapy, Highly Active; D015497:HIV-1; D006801:Humans; D007577:JC Virus / Q000187:drug effects / Q000502:physiology; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D008279:Magnetic Resonance Imaging; D016919:Meningitis, Cryptococcal / Q000150:complications; D008803:Mianserin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000078785:Mirtazapine; D053586:Virus Internalization / Q000187:drug effects
D008803:Mianserin; D000078785:Mirtazapine