Nickel- and rhodium-catalyzed addition of terminal silylacetylenes to propargyl amines: catalyst-dependent complementary regioselectivity.
The cross-addition of terminal silylacetylenes to gamma-arylated propargyl amines occurs efficiently via C-H cleavage by using either a nickel or rhodium catalyst. Taking advantage of the catalyst-controlled switching of regioselectivity in the reaction, both the 2- and 3-alkynylallylamines are readily accessible from the same starting materials.
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Naoto
N
Matsuyama
Koji
K
Hirano
Tetsuya
T
Satoh
Masahiro
M
Miura