Mood and cortisol responses following tryptophan-rich hydrolyzed protein and acute stress in healthy subjects with high and low cognitive reactivity to depression.
OBJECTIVE
It is suggested that stress particularly in subjects with high cognitive reactivity (CR), a psychological vulnerability marker of depression, may increase or even induce serotonergic vulnerability, which in turn may lead to reduced serotonin (5-HT) function, decreased stress coping and an increased risk to develop depressive symptoms. The aim of the present study was to investigate the beneficial effects of 5-HT augmentation through a tryptophan-rich hydrolyzed protein (HP) on mood and stress coping in subjects with high and low CR. We hypothesized that subjects with high CR are more responsive to the beneficial effects of HP than subjects with low CR particularly after acute stress exposure.


METHODS
In a double-blind, crossover study, participants' mood and cortisol was assessed before and after acute stress exposure either following intake of HP or a standard casein protein (CP) as control condition.


RESULTS
HP significantly increased positive mood in all subjects and dampened the cortisol response to acute stress. No differences were found between high and low CR subjects.


CONCLUSIONS
To conclude, because dietary treatment with HP has beneficial effects on mood and physiological stress coping in both high and low CR subjects, HP may be a good dietary method for augmenting brain TRP and 5-HT and thus 5-HT linked stress resilience.
Firk
Christine
C
Department of Clinical Psychological Science, Maastricht University, Maastricht, The Netherlands. christine.firk@psychology.unimaas.nl
Markus
C Rob
CR
D000339:Affect / Q000187:drug effects* / Q000502:physiology; D000704:Analysis of Variance; D003071:Cognition / Q000502:physiology*; D018592:Cross-Over Studies; D003863:Depression / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D008297:Male; D009483:Neuropsychological Tests; D011492:Protein Hydrolysates; D012463:Saliva / Q000737:chemistry; D012701:Serotonin / Q000097:blood / Q000378:metabolism*; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism* / Q000652:urine; D014364:Tryptophan / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D055815:Young Adult
D011492:Protein Hydrolysates; D012701:Serotonin; D014364:Tryptophan; D006854:Hydrocortisone