[In utero thrombosis of neonates: inherited thrombophilia?].
Thromboembolic events are relatively uncommon in childhood. It involves mainly children under one year of age and adolescents, with an incidence is 5.1/10000 live births. Authors present a course of disease of seven cases with neonatal thromboembolic events (2.5/admissions), diagnosed and treated at the Neonatal Division of Department of Pediatrics. In three of seven cases thrombosis proved to be of intrauterine origin. In each of the latter cases, inherited thrombophilia of the mothers was detected. Additional risk factors including infection could be revealed only in one case. Using in vivo and post mortem DNA analysis, mother-like-thrombophilia could not be confirmed in any of the newborns. Based on their experiences, authors suppose that undetected predisposing factors added to maternal thrombophilia can be considered as etiological factor. Authors suggest the intensive follow-up of pregnant women with thrombophilia and also their fetuses.
Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Gyermekgyógyászati Intézet, Debrecen, Nagyerdei körút 98. 4012. nagyand@dote.hu
Andrea
A
Nagy
Gábor
G
Mogyorósy
Csongor
C
Kiss
István
I
Pataki
Shemirani
S
Amir Houshang
Eva
E
Oláh
D001779:Blood Coagulation Factors / Q000378:metabolism; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009035:Mothers; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000235:genetics*; D019851:Thrombophilia / Q000097:blood / Q000235:genetics*; D013927:Thrombosis / Q000097:blood / Q000235:genetics*
D001779:Blood Coagulation Factors