Lowering cholesterol - a review on the role of plant sterols.
BACKGROUND
Plant sterols are an important but underused dietary component in the treatment of elevated blood cholesterol.


OBJECTIVE
This review discusses the background to plant sterol use and reviews evidence about its use in clinical practice.


CONCLUSIONS
When consumed in the recommended amounts, sterols alone decrease low density lipoprotein cholesterol; in combination with other dietary changes, low density lipoprotein can be further lowered. Most patients, whether they are on cholesterol lowering drugs or not, would benefit from using plant sterols, which are now available in milk and yoghurt as well as spreads. In animal models, plant sterols have been shown to reduce atherosclerosis despite an elevation in the blood level, however there is no hard end point data for this in humans.
Clifton
Peter
P
Department of Medicine, Adelaide University, South Australia. peter.clifton@csiro.au
D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001315:Australia; D002784:Cholesterol / Q000097:blood*; D003362:Cost-Benefit Analysis; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000191:economics; D010840:Phytosterols / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D010840:Phytosterols; D002784:Cholesterol