Baculovirus vector as a delivery vehicle for influenza vaccines.
The baculovirus vector has emerged as an efficient delivery vehicle for influenza vaccines. In addition to the ease and safety in expeditious production, recent improvements in baculovirus engineering to display foreign proteins on the surface and to express transgenes with suitable promoters in various cell lines have become milestones in the development of the baculovirus expression system. Surface-displayed and shuttle promoter-mediated baculovirus vaccines for influenza present advantages in immunogenicity and safety, as studied in several animal models. A variety of strategies, including the modification of envelope proteins for surface display, the selection of novel promoters for in vivo transductions and advancements in downstream processing, aid the improvement of baculovirus-based influenza vaccines and represent progress toward next-generation vaccines for influenza.
Animal Health Biotechnology, Temasek Life Sciences Laboratory, National University of Singapore, 117604 Singapore. hefang@tll.org.sg
Fang
F
He
Selvaraj
S
Madhan
Jimmy
J
Kwang
D000818:Animals; D016367:Baculoviridae / Q000235:genetics*; D005822:Genetic Vectors; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects / Q000235:genetics* / Q000276:immunology*
D007252:Influenza Vaccines