Amount of HIV DNA in peripheral blood mononuclear cells is proportional to the severity of HIV-1-associated neurocognitive disorders.
Human immunodeficiency virus (HIV) DNA in peripheral blood mononuclear cells was previously associated with neuropsychological function. By including individuals encompassing the full range of HIV-1-associated neurocognitive disorders, this study reports results from subjects with normal cognition, minor cognitive motor disorder, and HIV-1-associated dementia. Individuals with normal cognition had relatively low HIV DNA levels compared to those with minor cognitive motor disorder and HIV-1-associated dementia. Neuropsychological deficits were significantly associated with entry HIV DNA in all domains. These findings demonstrate for the first time that the severity of HIV-1-associated neurocognitive disorders is proportional to the amount of circulating HIV DNA.
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA. bshirami@hawaii.edu
Bruce
B
Shiramizu
Andrew E
AE
Williams
Cecilia
C
Shikuma
Victor
V
Valcour
D015526:AIDS Dementia Complex / Q000821:virology*; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000175:diagnosis / Q000821:virology*; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000523:psychology* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011336:Probability; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
D004279:DNA, Viral