Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae).
Ethanolic extract from the fruits of Pimpinella anisoides, an aromatic plant and a spice, exhibited activity against AChE and BChE, with IC(50) values of 227.5 and 362.1 microg/ml, respectively. The most abundant constituents of the extract were trans-anethole, (+)-limonene and (+)-sabinene. trans-Anethole exhibited the highest activity against AChE and BChE with IC(50) values of 134.7 and 209.6 microg/ml, respectively. The bicyclic monoterpene (+)-sabinene exhibited a promising activity against AChE (IC(50) of 176.5 microg/ml) and BChE (IC(50) of 218.6 microg/ml).
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Italy.
Federica
F
Menichini
Rosa
R
Tundis
Monica R
MR
Loizzo
Marco
M
Bonesi
Mariangela
M
Marrelli
Giancarlo A
GA
Statti
Francesco
F
Menichini
Filomena
F
Conforti
D000110:Acetylcholinesterase / Q000378:metabolism*; D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000302:isolation & purification / Q000494:pharmacology; D000081008:Bicyclic Monoterpenes; D002091:Butyrylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D053138:Cyclohexenes / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit; D000077222:Limonene; D039821:Monoterpenes / Q000302:isolation & purification / Q000494:pharmacology; D028042:Pimpinella / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000081008:Bicyclic Monoterpenes; D002800:Cholinesterase Inhibitors; D053138:Cyclohexenes; D039821:Monoterpenes; D010936:Plant Extracts; D013729:Terpenes; C035127:sabinene; D000077222:Limonene; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; C006578:anethole