Mortality in bronchiectasis: a long-term study assessing the factors influencing survival.
There is little literature about the mortality associated with bronchiectasis. The aim of the present study was to investigate factors affecting mortality in patients with bronchiectasis. In total, 91 patients were examined for aetiology, pulmonary function tests, high-resolution computed tomography, sputum microbiology and quality of life scores and were then followed over 13 yrs. Overall, 29.7% of the patients died. On multivariate analysis, age, St George's Respiratory Questionnaire activity score, Pseudomonas aeruginosa infection, total lung capacity (TLC), residual volume/TLC and the transfer factor coefficient were all independently associated with mortality. In patients with moderate to severe bronchiectasis, mortality is associated with a degree of restrictive and obstructive disease, poor gas transfer and chronic pseudomonas infection. These features should guide future research into disease progression, and identify those patients needing intensive treatment.
Host Defence Unit, Royal Brompton Hospital, London, UK.
M R
MR
Loebinger
A U
AU
Wells
D M
DM
Hansell
N
N
Chinyanganya
A
A
Devaraj
M
M
Meister
R
R
Wilson
D000328:Adult; D001987:Bronchiectasis / Q000382:microbiology / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D011552:Pseudomonas Infections / Q000401:mortality*; D011550:Pseudomonas aeruginosa; D012307:Risk Factors; D011795:Surveys and Questionnaires