Increased CD4+CD25+Foxp3+ T cells in peripheral blood of celiac disease patients: correlation with dietary treatment.
Regulatory CD4+ CD25+Foxp3+ T cells are involved in the regulation of immune response and inhibit protective antitumor immunity. Celiac disease (CD), a food gluten-sensitive enteropathy, is considered a T-cell-mediated autoimmune disease and is generally associated with an overall increased risk of cancer in CD patients. We observed a higher percentage of circulating CD4+CD25+Foxp3+ T cells and an increased Foxp3 expression in CD4+CD25+ T cells from untreated than from treated CD patients. In co-culture, CD4+CD25+ T cells from both treated and untreated CD patients significantly suppressed the proliferation of autologous CD4+CD25(-) T cells similarly to values in healthy subjects. Our study suggests that Treg proportion and Foxp3 expression in circulating CD4+CD25+ T cells could justify the increased global risk of malignancy in CD population and support the efficacy of lifelong gluten-free diet in the reduction of the cancer risk.
Frisullo
Giovanni
G
Institute of Neurology, Department of Neurosciences, Catholic University, Largo Agostino Gemelli 8, 00168 Rome, Italy.
Nociti
Viviana
V
Iorio
Raffaele
R
Patanella
Agata Katia
AK
Marti
Alessandro
A
Assunta
Bianco
B
Plantone
Domenico
D
Cammarota
Giovanni
G
Tonali
Pietro Attilio
PA
Batocchi
Anna Paola
AP
D000293:Adolescent; D000328:Adult; D015704:CD4 Antigens / Q000097:blood* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D002446:Celiac Disease / Q000178:diet therapy* / Q000276:immunology / Q000473:pathology; D049109:Cell Proliferation; D002478:Cells, Cultured; D055050:Diet, Gluten-Free; D005260:Female; D051858:Forkhead Transcription Factors / Q000097:blood* / Q000276:immunology; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood* / Q000276:immunology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000473:pathology; D055815:Young Adult
D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit