Molecular imaging of prostate cancer.
Prostate carcinoma is the most common non-cutaneous malignancy in males. Imaging of prostatic lesions is of great importance and aids in oncologic management and monitoring of therapy response. Particularly molecular imaging based on positron emission tomography (PET) and single photon emission computerized tomography (SPECT) has great potential. Using radio-labelled molecular probes, these approaches are highly sensitive and can provide key molecular and functional information on tumours. The identification of suitable targets based on unique genetic and biochemical features of cancer lesions is one of the core activities driving progress in molecular imaging of pathological processes. Nowadays, mainly metabolic probes are being used routinely for detection and staging of prostate cancer. The development of new specific receptor ligands and targeted probes and antibodies holds great promise to further enhance the performance of molecular imaging and to further improve the diagnosis and monitoring of prostate cancer.
Department of Nuclear Medicine, University Hospital Gasthuisberg, Herestraat 49, Bus 7003, B-3000 Leuven, Belgium. Kimy.Emonds@med.kuleuven.be
K M
KM
Emonds
J V
JV
Swinnen
L
L
Mortelmans
F M
FM
Mottaghy
D000818:Animals; D000951:Antigens, Neoplasm; D001839:Bombesin; D045744:Cell Line, Tumor; D002794:Choline; D015224:Dideoxynucleosides; D013196:Dihydrotestosterone / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D058851:GPI-Linked Proteins; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D009363:Neoplasm Proteins; D049268:Positron-Emission Tomography / Q000379:methods; D011467:Prostate / Q000000981:diagnostic imaging; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
C494901:16-fluorodihydrotestosterone; D000951:Antigens, Neoplasm; D015224:Dideoxynucleosides; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; C110843:PSCA protein, human; D019275:Radiopharmaceuticals; D013196:Dihydrotestosterone; D019788:Fluorodeoxyglucose F18; D002794:Choline; C002854:alovudine; D001839:Bombesin