Characterization of two key molecules of teleost innate immunity from rainbow trout (Oncorhynchus mykiss): MyD88 and SAA.
Toll-like receptors (TLR) are relevant for piscine innate immunity. TLR activation recruits several downstream factors regulating the expression of immunorelevant genes. We have characterized two key factors of innate immunity from rainbow trout: MyD88 as an adaptor protein interacting directly with TLRs, and serum amyloid A as an effector molecule induced by the activated Toll-like receptor signaling cascade. Both factors share a remarkable high degree of structural conservation with their mammalian orthologs suggesting that innate immune defense mechanisms may also functionally be conserved between fish and mammals.
Research Institute for the Biology of Farm Animals (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Alexander
A
Rebl
Tom
T
Goldammer
Uwe
U
Fischer
Bernd
B
Köllner
Hans-Martin
HM
Seyfert
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary / Q000737:chemistry; D007113:Immunity, Innate; D008969:Molecular Sequence Data; D053594:Myeloid Differentiation Factor 88 / Q000737:chemistry / Q000235:genetics*; D017686:Oncorhynchus mykiss / Q000276:immunology*; D000685:Serum Amyloid A Protein / Q000737:chemistry / Q000235:genetics*
D018076:DNA, Complementary; D053594:Myeloid Differentiation Factor 88; D000685:Serum Amyloid A Protein