[Role of the renin-angiotensin system in the regulation of vascular senescence].
Arterial components of the angiotensin II (Ang II) signaling cascade increase with aging and contribute to the pathogenesis of atherosclerosis, and inhibition of Ang II activity has been demonstrated to improve the morbidity and mortality of cardiovascular disease. Ang II signaling appears to play a critical role in regulating many of the stimuli and signals that govern vascular aging and atherogenesis. Recently, Ang II was reported to induce the premature senescence of vascular cells via the p53/p21-dependent pathway. The current review will discuss the mechanism by which Ang II contributes to vascular aging as well as the potential of anti-senescence therapy by inhibition of Ang II activity for age-associated diseases.
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine.
Tohru
T
Minamino
D000375:Aging / Q000502:physiology*; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001808:Blood Vessels / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology*
D000804:Angiotensin II