Leydig cell tumor and malignant lymphoma in a patient with nonclassical 21-hydroxylase deficiency.
A 46-year-old man was admitted in our hospital with hypoglycemia; his FPG was 43 mg/mL. Five years earlier, he underwent simultaneous surgeries for an adrenal adenoma, a benign Leydig cell tumor (LCT), and a malignant lymphoma. Based on the laboratory results, he was diagnosed as congenital adrenal hyperplasia (CAH) due to nonclassical 21-hydroxylase deficiency (21-OHD). On immunohistochemistry analysis using the antibody against adrenal-specific 11beta-hydroxylase antibody, the LCT showed both properties as a testicular cell and as an adrenal cell. The genetic background of 21-OHD might contribute to the development of malignant lymphoma. Such as a case of LCT and malignant lymphoma in a patient with 21-OHD seems to be rare.
Department of Aging and Geriatrics, Shinshu University, Matsumoto, Japan. dinaba@hsp.md.shinshu-u.ac.jp
Hidefumi
H
Inaba
Satoru
S
Suzuki
Satoshi
S
Shigematsu
Ken
K
Shinomiya
Hirokazu
H
Ohfusa
Yasuyo
Y
Shimojo
Takeshi
T
Uehara
Kiyoshi
K
Hashizume
D000310:Adrenal Gland Neoplasms / Q000209:etiology / Q000601:surgery; D000312:Adrenal Hyperplasia, Congenital / Q000150:complications* / Q000175:diagnosis*; D018246:Adrenocortical Adenoma / Q000209:etiology / Q000601:surgery; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis / Q000209:etiology; D007984:Leydig Cell Tumor / Q000209:etiology* / Q000601:surgery; D008223:Lymphoma / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013736:Testicular Neoplasms / Q000209:etiology* / Q000601:surgery