Lactones from Angiopteris caudatiformis.
Angiopterlactones A (1) and B (2), two unique lactones, and three known lactones, osmundalactone (3), osmundalin (4), and 3,5-dihydroxy-gamma-caprolactone (5), have been isolated from the rhizome of Angiopteris caudatiformis. The structures of 1 and 2 were determined by NMR and MS methods, and the structure of 2 was confirmed by X-ray crystallography. The absolute configurations of 1 and 2 were assigned by application of the CD excitation chirality method and the modified Mosher's method. Compound 1 was slightly cytotoxic against HeLa cells, with an IC(50) value of 68.8 microM, and compounds 3 and 4 showed moderate insect antifeeding activity against Plutella xylostella and Heliothis virescens.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.
Yong-Ming
YM
Yu
Jun-Shan
JS
Yang
Chao-Zhong
CZ
Peng
Valerie
V
Caer
Pu-Zhu
PZ
Cong
Zhong-Mei
ZM
Zou
Yang
Y
Lu
Shi-Ying
SY
Yang
Yu-Cheng
YC
Gu
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005247:Feeding Behavior / Q000187:drug effects; D029624:Ferns / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects; D027343:Rhizome / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; C550872:angiopterlactone A; C550873:angiopterlactone B