Endothelium-driven myocardial growth or nitric oxide at the crossroads.
Endothelium lining the coronary vasculature and the heart chambers is a dynamic sensor that serves a variety of functions including bidirectional communications with cardiac myocytes. Among endothelium-released factors, nitric oxide exerts multifactorial effects on various cell types in the heart and may play a role in growth of the vasculature and myocardial hypertrophy. This review summarizes new data regarding the endothelium-to-myocyte signaling focusing on its role in regulation of cardiac hypertrophy through a nitric-oxide-mediated paracrine signal.
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
Daniela
D
Tirziu
Michael
M
Simons
D000818:Animals; D001779:Blood Coagulation Factors / Q000378:metabolism; D006332:Cardiomegaly / Q000378:metabolism*; D003326:Coronary Circulation; D016232:Endothelins / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006801:Humans; D015640:Ion Channel Gating; D009206:Myocardium / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D052248:Nitric Oxide Synthase Type I / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D019899:Paracrine Communication; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D015398:Signal Transduction; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism
D001779:Blood Coagulation Factors; D016232:Endothelins; D010982:Platelet-Derived Growth Factor; D011453:Prostaglandins; D042442:Vascular Endothelial Growth Factors; D009569:Nitric Oxide; D005346:Fibroblast Growth Factors; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III