Diuretic properties of Orthosiphon stamineus Benth.
BACKGROUND
Orthosiphon stamineus has been used in traditional medicine for centuries especially to treat diseases of the urinary system.


OBJECTIVE
To investigate the diuretic activity, to elucidate its possible mechanism and to evaluate the renal effects of Orthosiphon stamineus extract.


METHODS
Water extracts were administered orally at doses of 5 and 10 mg/kg to Sprague-Dawley rats and the control groups were given commercial diuretic drugs either furosemide or hydrochlorthiazide at 10 mg/kg. Urine volume, urine pH, urine density and urine electrolytes were determined every hour for 4h. Blood was assayed for glucose, albumin, blood urea nitrogen (BUN) and creatinine.


RESULTS
O. stamineus extract exhibited dose-dependent diuretic activity. However, excretion of Na+ and Cl(-) was not markedly elevated, but urinary excretion of K+ was significantly increased. O. stamineus extracts slightly increased the serum BUN, creatinine and blood glucose level. Although these levels were statistically significant when compared to control, these levels were still within normal range.


CONCLUSIONS
O. stamineus exhibited diuretic activity, but was less potent than furosemide and hydrochlorothiazide. Care should be taken when consuming this herb as slight increase of kidney function enzymes was recorded.
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
Y
Y
Adam
M N
MN
Somchit
M R
MR
Sulaiman
A A
AA
Nasaruddin
A
A
Zuraini
A A
AA
Bustamam
Z A
ZA
Zakaria
D000818:Animals; D001786:Blood Glucose; D001806:Blood Urea Nitrogen; D002712:Chlorides / Q000652:urine; D003404:Creatinine / Q000097:blood; D004232:Diuretics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005665:Furosemide / Q000494:pharmacology; D006852:Hydrochlorothiazide / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D031342:Orthosiphon; D010936:Plant Extracts / Q000494:pharmacology*; D011188:Potassium / Q000652:urine*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000652:urine; D014554:Urination / Q000187:drug effects*; D014556:Urine / Q000737:chemistry
D001786:Blood Glucose; D002712:Chlorides; D004232:Diuretics; D010936:Plant Extracts; D006852:Hydrochlorothiazide; D005665:Furosemide; D012964:Sodium; D003404:Creatinine; D011188:Potassium