Synchronous multifocal HPV-related neoplasm involving both the genital tract and the head-and-neck area: a case report of Fanconi anemia.
We report the case of a 32-year-old woman who presented with multiple squamous cell neoplasms synchronously arising in the cervix, vulva, oral cavity and oropharynx. During the period when the patient was treated by radiotherapy, she developed severe radiation mucositis and pancytopenia. Immunofluorescence staining for foci of the monoubiquitinated form of FANCD2 revealed a complete absence of such foci in all cancer tissues that were examined.
Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea.
Tae-Jin
TJ
Han
Chang-Hun
CH
Lee
Chong-Woo
CW
Yoo
Hye-Jin
HJ
Shin
Hyun-Jin
HJ
Park
Kwan Ho
KH
Cho
Joo-Yong
JY
Park
Sung-Won
SW
Choi
Joo-Young
JY
Kim
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000821:virology; D005199:Fanconi Anemia / Q000150:complications*; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications* / Q000821:virology; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000821:virology; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology