[Polymethylene derivatives of nucleic bases with omega-functional groups: VII. Cytotoxicity in the series of N-(2-oxocyclohexyl)-omega-oxoalkyl substituted purines and pyrimidines].
New polymethylene derivatives of nucleic bases with a beta-diketo function in the omega-position were obtained by alkylation of uracil, thymine, cytosine, hypoxanthine, adenine, and N(2)-isobutyryl guanine with 2-omega-chloroal-kanoyl)cyclohexanones. The physical and chemical characteristics of the compounds synthesized and their effect on the K562 and HCT116 tumor cell lines were studied.
Komissarov
V V
VV
Volgareva
G M
GM
Ol'shanskaia
Ia S
IaS
Chernyshova
M E
ME
Zavalishina
L E
LE
Frank
G A
GA
Shtil'
A A
AA
Kritsyn
A M
AM
D000478:Alkylation; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003596:Cytosine / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004347:Drug Interactions; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D019271:Hypoxanthine / Q000494:pharmacology; D011687:Purines / Q000737:chemistry / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013941:Thymine / Q000494:pharmacology; D014498:Uracil / Q000494:pharmacology
D000970:Antineoplastic Agents; D011687:Purines; D011743:Pyrimidines; D019271:Hypoxanthine; D014498:Uracil; D004317:Doxorubicin; D003596:Cytosine; D013941:Thymine