Resective surgery is possible in patients with temporal lobe epilepsy due to bilateral isolated hippocampal malformation.
Various hippocampal malformations have been described in the context of widespread cortical malformations in patients with epilepsy. Isolated hippocampal malformations however are very rarely identified on MR imaging studies. Little is known about the epileptogenicity of these malformations and their pathologic appearance. We present a case with severe bilateral hippocampal malformations who underwent right temporal lobectomy due to intractable temporal lobe epilepsy. Postoperative examination of the resected hippocampus revealed abnormal shape of the dentate gyrus and an atypical convolution of the CA1 pyramidal cell-subicular layers. After surgery, the patient has been seizure free.
Dericioglu
Nese
N
Hacettepe University, Institute of Neurological Sciences and Psychiatry, Department of Neurology, Sihhiye 06100, Ankara, Turkey. nesedericioglu@yahoo.com
Oguz
Kader Karli
KK
Soylemezoglu
Figen
F
Akalan
Nejat
N
Saygi
Serap
S
D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D011859:Radiography; D013702:Temporal Lobe / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult