Myocardial strain measurement with 2-dimensional speckle-tracking echocardiography: definition of normal range.
The interpretation of wall motion is an important component of echocardiography but remains a source of variation between observers. It has been believed that automated quantification of left ventricular (LV) systolic function by measurement of LV systolic strain from speckle-tracking echocardiography might be helpful. This multicenter study of nearly 250 volunteers without evidence of cardiovascular disease showed an average LV peak systolic strain of -18.6 +/- 0.1%. Although strain was influenced by weight, blood pressure, and heart rate, these features accounted for only 16% of variance. However, there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges.
Marwick
Thomas H
TH
University of Queensland, Department of Medicine, Princess Alexandra Hospital, Brisbane, Queensland, Australia. t.marwick@uq.edu.au
Leano
Rodel L
RL
Brown
Joseph
J
Sun
Jing-Ping
JP
Hoffmann
Rainer
R
Lysyansky
Peter
P
Becker
Michael
M
Thomas
James D
JD
D000328:Adult; D001315:Australia; D004452:Echocardiography; D005260:Female; D005858:Germany; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007557:Israel; D008297:Male; D008875:Middle Aged; D009038:Motion; D009200:Myocardial Contraction; D015588:Observer Variation; D009820:Ohio; D011237:Predictive Value of Tests; D012016:Reference Values; D015203:Reproducibility of Results; D016277:Ventricular Function, Left