Comparison of paraben stability in human and rat skin.
Parabens are widely used preservatives in topical products, and are estrogenic in numerous experimental models. The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absorption of parabens, combined with low metabolism rates, may lead to prolonged estrogenic effects in the skin.
Harville
Heather M
HM
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Rd., Ann Arbor, MI 48105, USA.
Voorman
Richard
R
Prusakiewicz
Jeffery J
JJ
D000279:Administration, Cutaneous; D000818:Animals; D005260:Female; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D010226:Parabens / Q000493:pharmacokinetics*; D011310:Preservatives, Pharmaceutical / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013045:Species Specificity
D010226:Parabens; D011310:Preservatives, Pharmaceutical