Hormonal and nutritional regulation of insect fat body development and function.
The insect fat body is an organ analogue to vertebrate adipose tissue and liver and functions as a major organ for nutrient storage and energy metabolism. Similar to other larval organs, fat body undergoes a developmental "remodeling" process during the period of insect metamorphosis, with the massive destruction of obsolete larval tissues by programmed cell death and the simultaneous growth and differentiation of adult tissues from small clusters of progenitor cells. Genetic ablation of Drosophila fat body cells during larval-pupal transition results in lethality at the late pupal stage and changes sizes of other larval organs indicating that fat body is the center for pupal development and adult formation. Fat body development and function are largely regulated by several hormonal (i.e. insulin and ecdysteroids) and nutritional signals, including oncogenes and tumor suppressors in these pathways. Combining silkworm physiology with fruitfly genetics might provide a valuable system to understand the mystery of hormonal regulation of insect fat body development and function.
Liu
Ying
Y
Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Liu
Hanhan
H
Liu
Shumin
S
Wang
Sheng
S
Jiang
Rong-Jing
RJ
Li
Sheng
S
D053687:Adult Stem Cells / Q000166:cytology; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D030801:Animals, Genetically Modified; D017209:Apoptosis; D012831:Bombyx / Q000166:cytology / Q000254:growth & development* / Q000502:physiology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics / Q000254:growth & development* / Q000502:physiology*; D005216:Fat Body / Q000166:cytology / Q000254:growth & development* / Q000502:physiology*; D017344:Genes, Insect; D016147:Genes, Tumor Suppressor; D007301:Insect Hormones / Q000502:physiology; D007814:Larva / Q000166:cytology / Q000254:growth & development; D008675:Metamorphosis, Biological; D008954:Models, Biological; D009857:Oncogenes; D011679:Pupa / Q000166:cytology / Q000254:growth & development; D015398:Signal Transduction
D007301:Insect Hormones