Varicella as a trigger of atypical haemolytic uraemic syndrome associated with complement dysfunction: two cases.
We report two cases of children who presented with haemolytic uraemic syndrome following varicella infection. One of them had a membrane cofactor protein mutation, and the other had anti-factor H antibodies. These observations show that infectious agents such as varicella-zoster virus may be the trigger of haemolytic uraemic syndrome in patients with complement dysregulation.
Kwon
Theresa
T
Pediatric Nephrology Department, Hôpital Robert Debré, Université Paris, France. theresa.kwon@rdb.aphp.fr
Belot
Alexandre
A
Ranchin
Bruno
B
Baudouin
Véronique
V
Fremeaux-Bacchi
Véronique
V
Dragon-Durey
Marie-Agnès
MA
Cochat
Pierre
P
Loirat
Chantal
C
D001323:Autoantibodies / Q000097:blood*; D002644:Chickenpox / Q000150:complications* / Q000235:genetics / Q000276:immunology*; D002675:Child, Preschool; D017242:Complement Factor H / Q000037:antagonists & inhibitors* / Q000276:immunology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology* / Q000235:genetics / Q000276:immunology*; D006579:Heterozygote; D006801:Humans; D008297:Male; D051916:Membrane Cofactor Protein / Q000172:deficiency* / Q000235:genetics; D017354:Point Mutation; D013997:Time Factors
D001323:Autoantibodies; C497857:CD46 protein, human; D051916:Membrane Cofactor Protein; D017242:Complement Factor H