Effects of levobupivacaine infiltration on postoperative analgesia and stress response in children following inguinal hernia repair.
OBJECTIVE
The present study compared the postoperative analgesic effects of preincisional and postincisional wound infiltration with levobupivacaine and postoperative cortisol and prolactin levels in children following inguinal hernia repair.


METHODS
Ninety-six children aged 2-10 years who were undergoing elective inguinal hernia repair were randomly enrolled in this study. In group A (n = 32), 0.25 ml kg levobupivacaine (5 mg ml) was infiltrated after induction of general anaesthesia. In group B (n = 32), 0.25 ml kg levobupivacaine (5 mg ml) was infiltrated before the end of the surgery. Group C (n = 32) did not receive levobupivacaine infiltration at any time. Mean arterial pressure, heart rate, objective pain score, adverse effects and the number of rescue analgesics were recorded for 24 h. Blood samples were withdrawn following induction of anaesthesia and at 40 min after the end of surgery for measurement of blood cortisol and prolactin levels.


RESULTS
The rescue analgesic administration, objective pain scores, heart rate, postoperative plasma cortisol and prolactin levels were higher in group C than in either group A or group B (P < 0.05). There were no differences in these parameters between the two treatment groups (P > 0.05). Postoperative plasma cortisol and prolactin levels were significantly higher in all three groups than preoperative plasma cortisol and prolactin levels (P < 0.001).


CONCLUSIONS
Wound infiltration with levobupivacaine after induction of general anaesthesia and before the end of the surgery both provide postoperative pain relief following hernia repair, and decrease the stress response to postoperative pain.
Cnar
Surhan Ozer
SO
Department of Anesthesiology, Sisli Etfal Teaching and Research Hospital, Istanbul, Turkey. asurhan@yahoo.com
Kum
Ulkü
U
Cevizci
Nuri
N
Kayaoglu
Semra
S
Oba
Sibel
S
D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007322:Instillation, Drug; D000077554:Levobupivacaine; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011388:Prolactin / Q000097:blood / Q000187:drug effects; D011446:Prospective Studies; D016037:Single-Blind Method
D000779:Anesthetics, Local; D011388:Prolactin; D000077554:Levobupivacaine; D006854:Hydrocortisone; D002045:Bupivacaine