General one-pot method for the preparation of N-tert-butanesulfinylamine diastereomer mixtures as standards for stereoselectivity determinations.
The one-pot preparation of N-sulfinylamine diastereomers proceeds in excellent yields (84-98%) for a diverse set of N-sulfinyl imine addition products. The method is operationally simple and extractive isolation provides analytically pure mixtures of diastereomers as standards for the rapid and accurate determination of N-sulfinylamine diastereomeric purity.
Department of Chemistry, University of California, Berkeley, California 94720, USA.
Katrien
K
Brak
Kimberly T
KT
Barrett
Jonathan A
JA
Ellman
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002073:Butanes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity; D013452:Sulfonium Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D000588:Amines; D002073:Butanes; C542421:N-tert-butanesulfinylamine; D013452:Sulfonium Compounds