[Expression and significance of hTERT, c-myc and Ki-67 in hepatocellular carcinoma].
OBJECTIVE
To study the correlation of expression of hTERT, c-myc and Ki-67 with the clinical pathological feature of hepatocellular carcinoma and explore the relationship among the three factors.


METHODS
The expressions of hTERT, c-myc and Ki-67 in 37 cancer tissues and 5 normal tissues were assessed by immunohistochemical method.


RESULTS
The positive rates of hTERT, c-myc and Ki-67 in the cancer tissue were higher than those in normal tissues (P<0.05). The expressions of hTERT, c-myc and Ki-67 had nothing to do with age, sex, metastasis and the volume of tumor(P>0.05). With histology stage reducing, the expression of hTERT, c-myc and Ki-67 increased obviously. There is no correlation between hTERT and c-myc(P>0.05), but it's positive correlation between hTERT and Ki-67(P<0.05). With the expression of Ki-67 increasing, hTERT and c-myc increased.


CONCLUSIONS
The over-expression of hTERT, c-myc and Ki-67 may play a vital role in the progress of hepatocellular carcinoma developing. The expressions of three factors in hepatocellular carcinoma are closely associated.
Fang
Yong-wei
YW
Shiyou Medical School of Hebei Medical University, Langfang 065000, China. fanyongwei.1969@yahoo.com.cn
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*; D019098:Telomerase / Q000096:biosynthesis*
D019394:Ki-67 Antigen; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; C509186:TERT protein, human; D019098:Telomerase