Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines.
Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzoimidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K(a) values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives.
AV Bogatsky Physico-Chemical Institute of NAS of Ukraine, Odessa, Ukraine.
Elena A
EA
Lyakhova
Yulia A
YA
Gusyeva
Julia V
JV
Nekhoroshkova
Lev M
LM
Shafran
Sergey A
SA
Lyakhov
D000818:Animals; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D007093:Imidazoles; D011799:Quinazolines; D004247:DNA