Transient elastography for the prediction of oxaliplatin-associated liver injury in colon cancer patients: a preliminary analysis.
OBJECTIVE
The prognosis of advanced colon cancer has improved significantly over the last decade since new chemotherapy regimens including oxaliplatin have been developed. However, oxaliplatin-induced liver injury and characterized hepatic hemostatic status can occur after chemotherapy. The assessment of this type of liver injury is often difficult.


METHODS
Elastography (Fibroscan) was used to evaluate liver injury in five cases before and after 5-FU, leucovorin, and oxaliplatin combination (FOLFOX) treatment.


RESULTS
A clear change was observed in the stiffness of liver after chemotherapy within 48 h, and the hepatic stiffness was normalized in most cases after 2 weeks. Among the five patients, one patient showed aberrant elevation after a FOLFOX treatment, and the patient showed liver injury pathologically.


CONCLUSIONS
Elastography is a good tool for evaluating hepatic injury after FOLFOX treatment.
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. okieiji@surg2.med.kyushu-u.ac.jp
Eiji
E
Oki
Yoshihiro
Y
Kakeji
Akinobu
A
Taketomi
Yoichi
Y
Yamashita
Kippei
K
Ohgaki
Noboru
N
Harada
Tomohiro
T
Iguchi
Kotaro
K
Shibahara
Noriaki
N
Sadanaga
Masaru
M
Morita
Yoshihiko
Y
Maehara
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D010865:Pilot Projects
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin