Two novel monoterpene-chalcone conjugates isolated from the seeds of Alpinia katsumadai.
Three monoterpene-chalcone conjugates, including two novel compounds isorubraine (2) and sumadain C (3), and a known compound rubraine (1) were isolated from the seeds of Alpinia katsumadai. Their structures and relative configurations were established by NMR spectroscopy and X-ray crystallography. Cytotoxic activities of these compounds were evaluated against cell lines HepG2, MCF-7 and MAD-MB-435, and compound 3 exhibited potent cytotoxic activity.
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Tong Jia Xiang, Nanjing, People's Republic of China.
Shu-Zhen
SZ
Hua
Jian-Guang
JG
Luo
Xiao-Bing
XB
Wang
Jun-Song
JS
Wang
Ling-Yi
LY
Kong
D032429:Alpinia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D045744:Cell Line, Tumor; D002599:Chalcone / Q000737:chemistry*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008968:Molecular Conformation; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry; D012639:Seeds / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones; D039821:Monoterpenes; C541543:isorubraine; C541542:sumadain C; D002599:Chalcone