Nodal and extranodal soft tissue polymorphous hemangioendothelioma: a case report and review of the literature.
BACKGROUND
Polymorphous hemangioendothelioma is a rare vascular tumor of borderline malignant potential and only 10 cases have been described in the literature so far.


RESULTS
We report a case of nodal and extranodal polymorphous hemangioendothelioma and review the literature. A 66-year-old man with an unremarkable past medical history was admitted for a left submandibular mass. The main nodule was composed of angiosarcoma-like areas mixed with angiomatous features; some vascular spaces with hobnail endothelium were seen. The tumor involved two adjacent lymph nodes. Immunohistochemically, the neoplastic cells were strongly positive for CD31 and vimentin. After a few months the tumor recurred and the patient was treated with radiation therapy.


CONCLUSIONS
Polymorphous hemangioendothelioma is a distinct entity in the hemangioendothelioma group with its own clinical and histological features.
Falleti
Jessica
J
Department of Biomorphological and Functional Sciences, Pathology Section, Federico II University, Naples, Italy.
Siano
Maria
M
De Cecio
Rossella
R
Somma
Anna
A
Pettinato
Guido
G
Insabato
Luigi
L
D000368:Aged; D044963:Biopsy, Fine-Needle; D006390:Hemangioendothelioma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D019647:Oral Surgical Procedures; D011878:Radiotherapy; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy