What is your diagnosis? Intracranial mass in a dog.
A 9-year-old, spayed female Chihuahua was presented for evaluation of acute, progressive neurologic disease. On physical examination the dog was depressed and laterally recumbent. The dog had marked neutrophilia with a toxic left shift and monocytosis. Using computed tomography with contrast enhancement a large intracranial mass lesion was identified in the rostral portion of the brain. The mass extended from the central thalamic region rostral to the cribiform plate and obliterated the lateral ventricles. A fine needle aspirate of the mass contained moderately pleomorphic polygonal cells with many intranuclear cytoplasmic pseudoinclusions (ICPs). The primary differential diagnosis was meningioma, based on cell morphology and the presence of ICPs. At necropsy, the mass was well-demarcated, unencapsulated, and densely cellular. Cells were arranged in papillary projections on fibrovascular stalks, and eosinophilic ICPs and nuclear folding were frequently seen. Cavitated areas of necrosis throughout the tumor mass were filled with intact and degenerated neutrophils. The histopathologic diagnosis was malignant papillary meningioma. ICPs are not frequently observed in Wright-stained cytologic preparations but may be found in many types of neoplasms, including meningiomas.
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada. naomi.harms@usask.ca
N Jane
NJ
Harms
Ryan M
RM
Dickinson
Belle Marie D
BM
Nibblett
Bruce K
BK
Wobeser
D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology*; D004285:Dogs; D005260:Female; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008579:Meningioma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*