Re-expression of locomotor function after partial spinal cord injury.
After a complete spinal section, quadruped mammals (cats, rats, and mice) can generally regain hindlimb locomotion on a treadmill because the spinal cord below the lesion can express locomotion through a neural circuitry termed the central pattern generator (CPG). In this review, we propose that the spinal CPG also plays a crucial role in the locomotor recovery after incomplete spinal cord injury.
Department of Physiology, Groupe de Recherche sur le Système Nerveux Central, Faculty of Medicine, Université de Montréal, Montreal, Canada. serge.rossignol@umontreal.ca
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Rossignol
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Barrière
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Alluin
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Frigon
D000222:Adaptation, Physiological; D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D006801:Humans; D007323:Instinct; D008124:Locomotion / Q000502:physiology*; D051379:Mice; D009416:Nerve Regeneration / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D013119:Spinal Cord Injuries / Q000503:physiopathology*