[Urinary iodine in patients with auto-immune thyroid disorders in Santo André, SP, is comparable to normal controls and has been steady for the last 10 years].
OBJECTIVE
Evaluate whether the increase of iodine in the diet would be the triggering factor for auto-immune thyropathies in the city of Santo André, SP.


METHODS
Urinary iodine was determined in samples isolated from 58 patients, divided in 4 Groups, and in 13 normal individuals (controls).


RESULTS
Urinary Iodine: Group 1--hyperthyroidism = 203.5+/-152.71 microg/ L(mean+/-sd); Group 2--hypothyroidism = 258.31+/-148,2 microg/L; Group 3--chronic auto-immune thyroiditis = 244.29+/-191.6 microg/L; Group 4--(Amiodarone) = 1157.5+/-261.8 microg/L; Group 5--Controls = 262.31+/-146.2 microg/L. On comparing the means of urinary iodine among the groups, the means for groups 1, 2, 3, and 5 did not present significant differences (p>0.05), and all differed from group 4 (p<0.05). Urinary iodine obtained in groups 1, 2, 3 and 5, obtained in 2002-03, is not different from the values determined in students in 1994 in Santo André.


CONCLUSIONS
This study shows evidence that iodine should not be considered as the responsible agent for auto-immune thyropathies in Santo André, and other environmental factors should be investigated.
Disciplina de Endocrinologia, Departamento de Clínica Médica, Universidade de São Paulo, Rua Dr. Gabriel dos Santos 405, São Paulo, SP. mangelazaccarelli@yahoo.com.br
Maria Angela Zaccarelli
MA
Marino
Lourdes Conceição
LC
Martins
Roberto Z
RZ
Esteves
Teresa S
TS
Kasamatsu
Rui M B
RM
Maciel
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D001938:Brazil; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004032:Diet / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007455:Iodine / Q000008:administration & dosage / Q000652:urine*; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis / Q000209:etiology / Q000652:urine*; D013997:Time Factors; D014463:Ultrasonography; D055815:Young Adult
D015415:Biomarkers; D007455:Iodine