Molecular modelling study of the 3D structure of the bovine viral diarrhea virus (BVDV) helicase.
Bovine viral diarrhea virus (BVDV) is a member of the Flaviviridae family of viruses and constitutes a very important pathogen for livestock around the world. The viral helicase is an enzyme essential for the proliferation and transmission of the virus. In this work a 3D-model of the BVDV helicase was produced using homology modelling techniques and the known 3D-structure of the hepatitis C helicase of the Flaviviridae family as template, in an attempt to provide the means for structure-based design of novel anti-BVDV agents.
Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.
Andrea
A
Brancale
Chrisanthy
C
Vlachaki
Dimitrios
D
Vlachakis
D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D000595:Amino Acid Sequence; D003198:Computer Simulation; D017124:Conserved Sequence; D001908:Diarrhea Viruses, Bovine Viral / Q000201:enzymology*; D016174:Hepacivirus / Q000201:enzymology; D021621:Imaging, Three-Dimensional; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D020365:RNA Helicases / Q000737:chemistry* / Q000378:metabolism; D012367:RNA, Viral / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment; D055672:Static Electricity; D040681:Structural Homology, Protein; D013379:Substrate Specificity
D012367:RNA, Viral; D000255:Adenosine Triphosphate; D020365:RNA Helicases