Outcome measures for evaluation of treatments for osteonecrosis.
With the advent of cell-based therapies, biologics, and pharmaceuticals for the potential treatment of osteonecrosis, it is important to conduct evaluations using scientifically accepted outcomes measures. For the treatment of osteonecrosis, most studies have focused on pain relief, surgery, or the need for surgery, disease progression (advancing stage), and change in lesion size. Quantification of imaging techniques continue to gain in sophistication but have not yet been validated for use in clinical trials. Despite recent interest in using biomarkers or genetic markers in the diagnosis and analysis of disease progression, more research is needed to determine the sensitivity and specificity of these techniques with respect to osteonecrosis.
Department of Orthopaedic Surgery, Johns Hopkins Orthopaedics at Good Samaritan Hospital, 5601 Loch Raven Boulevard, Suite 201, GSH POB, Baltimore, MD 21239, USA. ljones3@jhmi.edu
Lynne C
LC
Jones
Marc W
MW
Hungerford
Harpal S
HS
Khanuja
David S
DS
Hungerford
D017690:Cell Transplantation / Q000379:methods*; D018450:Disease Progression; D006801:Humans; D010020:Osteonecrosis / Q000000981:diagnostic imaging / Q000601:surgery*; D017063:Outcome Assessment, Health Care; D011859:Radiography