Novel drug-loaded gelatin films and their sustained-release performance.
A new particulate drug delivery system with gelatin matrix containing Ibuprofen as a model drug molecule was developed for an epidermis drug prolonged release. Gelatin films containing Ibuprofen-loaded poly-epsilon-caprolactone (PCL) microspheres have been developed on evaporation of organic solvent from an oil-in-water emulsion followed by cross-linking. The microspheres were characterized for particle size, encapsulation efficiency, and surface morphology. Water uptake, matrix erosion, and drug release profile of the microsphere-film system were investigated. The results indicated that drug-loaded microspheres introduced in this system successfully prolonged drug release time. This kind of microsphere-film system combined good adhesion, typical for gelatin films, with the sustained release performance of PCL microspheres.
Department of Macromolecular Science, Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Fudan University, Shanghai 200433, China.
Mei
M
Lin
Sheng
S
Meng
Wei
W
Zhong
Rui
R
Cai
Qiangguo
Q
Du
Piotr
P
Tomasik
D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005780:Gelatin / Q000737:chemistry*; D006868:Hydrolysis; D007052:Ibuprofen / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D014867:Water / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D012997:Solvents; D014867:Water; C016240:polycaprolactone; D005780:Gelatin; D007052:Ibuprofen