A common variant on chromosome 11q13 is associated with atopic dermatitis.
We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P(combined) = 7.6 x 10(-10)). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.
Esparza-Gordillo
Jorge
J
Pediatric Pneumology and Immunology, Charité Universitätsmedizin Berlin, Germany.
Weidinger
Stephan
S
Fölster-Holst
Regina
R
Bauerfeind
Anja
A
Ruschendorf
Franz
F
Patone
Giannino
G
Rohde
Klaus
K
Marenholz
Ingo
I
Schulz
Florian
F
Kerscher
Tamara
T
Hubner
Norbert
N
Wahn
Ulrich
U
Schreiber
Stefan
S
Franke
Andre
A
Vogler
Rainer
R
Heath
Simon
S
Baurecht
Hansjörg
H
Novak
Natalija
N
Rodriguez
Elke
E
Illig
Thomas
T
Lee-Kirsch
Min-Ae
MA
Ciechanowicz
Andrzej
A
Kurek
Michael
M
Piskackova
Tereza
T
Macek
Milan
M
Lee
Young-Ae
YA
Ruether
Andreas
A
D000293:Adolescent; D016022:Case-Control Studies; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult