Leukoaraiosis severity and list-learning in dementia.
In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores <4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while severe LA was predicted to be associated with a dysexecutive profile. List-learning performances were standardized to a group of healthy older adults (n = 24). Analyses were conducted on a set of four factors derived from the list-learning paradigm, as well as error scores. Data indicate that LA severity is an important marker for understanding list learning in dementia.
Price
Catherine C
CC
Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, Florida, 32610, USA. cep23@phhp.ufl.edu
Garrett
Kelly Davis
KD
Jefferson
Angela L
AL
Cosentino
Stephanie
S
Tanner
Jared J
JJ
Penney
Dana L
DL
Swenson
Rodney
R
Giovannetti
Tania
T
Bettcher
Brianne Magouirk
BM
Libon
David J
DJ
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003704:Dementia / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007807:Language Tests; D049292:Leukoaraiosis / Q000145:classification / Q000150:complications* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology; D012691:Serial Learning / Q000502:physiology*; D012720:Severity of Illness Index