Organohalogen contaminants and metabolites in cerebrospinal fluid and cerebellum gray matter in short-beaked common dolphins and Atlantic white-sided dolphins from the western North Atlantic.
Concentrations of several congeners and classes of organohalogen contaminants (OHCs) and/or their metabolites, namely organochlorine pesticides (OCs), polychlorinated biphenyls (PCBs), hydroxylated-PCBs (OH-PCBs), methylsulfonyl-PCBs (MeSO(2)-PCBs), polybrominated diphenyl ether (PBDE) flame retardants, and OH-PBDEs, were measured in cerebrospinal fluid (CSF) of short-beaked common dolphins (n = 2), Atlantic white-sided dolphins (n = 8), and gray seal (n = 1) from the western North Atlantic. In three Atlantic white-sided dolphins, cerebellum gray matter (GM) was also analyzed. The levels of OCs, PCBs, MeSO(2)-PCBs, PBDEs, and OH-PBDEs in cerebellum GM were higher than the concentrations in CSF. 4-OH-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) was the only detectable OH-PCB congener present in CSF. The sum (Sigma) OH-PCBs/Sigma PCB concentration ratio in CSF was approximately two to three orders of magnitude greater than the ratio in cerebellum GM for dolphins.
Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA. emontie@marine.usf.edu
Eric W
EW
Montie
Christopher M
CM
Reddy
Wouter A
WA
Gebbink
Katie E
KE
Touhey
Mark E
ME
Hahn
Robert J
RJ
Letcher
D000818:Animals; D001267:Atlantic Ocean; D002531:Cerebellum / Q000378:metabolism*; D050696:Common Dolphins / Q000134:cerebrospinal fluid / Q000378:metabolism; D004289:Dolphins / Q000134:cerebrospinal fluid / Q000378:metabolism*; D004784:Environmental Monitoring; D005260:Female; D006846:Hydrocarbons, Halogenated / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D011078:Polychlorinated Biphenyls / Q000134:cerebrospinal fluid / Q000378:metabolism; D046048:Seals, Earless / Q000134:cerebrospinal fluid / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000134:cerebrospinal fluid / Q000378:metabolism*; D014877:Water Pollution, Chemical / Q000706:statistics & numerical data
D006846:Hydrocarbons, Halogenated; D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls