Receptive fields in primate retina are coordinated to sample visual space more uniformly.
In the visual system, large ensembles of neurons collectively sample visual space with receptive fields (RFs). A puzzling problem is how neural ensembles provide a uniform, high-resolution visual representation in spite of irregularities in the RFs of individual cells. This problem was approached by simultaneously mapping the RFs of hundreds of primate retinal ganglion cells. As observed in previous studies, RFs exhibited irregular shapes that deviated from standard Gaussian models. Surprisingly, these irregularities were coordinated at a fine spatial scale: RFs interlocked with their neighbors, filling in gaps and avoiding large variations in overlap. RF shapes were coordinated with high spatial precision: the observed uniformity was degraded by angular perturbations as small as 15 degrees, and the observed populations sampled visual space with more than 50% of the theoretical ideal uniformity. These results show that the primate retina encodes light with an exquisitely coordinated array of RF shapes, illustrating a higher degree of functional precision in the neural circuitry than previously appreciated.
Gauthier
Jeffrey L
JL
Salk Institute for Biological Studies, La Jolla, California, United States of America. gauthier@salk.edu
Field
Greg D
GD
Sher
Alexander
A
Greschner
Martin
M
Shlens
Jonathon
J
Litke
Alan M
AM
Chichilnisky
E J
EJ
D000818:Animals; D001931:Brain Mapping; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*; D011323:Primates; D012160:Retina / Q000166:cytology / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000502:physiology*; D014785:Vision, Ocular / Q000502:physiology; D014794:Visual Fields / Q000502:physiology*; D014795:Visual Pathways / Q000166:cytology / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*