The role of PPARs in modulating cardiac metabolism in diabetes.
Diabetes mellitus is an important risk factor for the development of cardiovascular disease. The impact of diabetes on the heart in part resides in the changes in metabolic fuel availability evoked by lack of insulin or resistance to its action. This review addresses how the metabolic abnormalities associated with poorly controlled diabetes impact cardiac fuel supply and handling, with emphasis on the coordinating roles of the PPARs.
Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, St Bartholomew's, London, UK. m.j.holness@qmul.ac.uk
Mark J
MJ
Holness
Salma
S
Samsuddin
Mary C
MC
Sugden
D000818:Animals; D002940:Circadian Rhythm; D003920:Diabetes Mellitus / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D050356:Lipid Metabolism; D009206:Myocardium / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology*; D020033:Protein Isoforms
D016328:NF-kappa B; D047492:Peroxisome Proliferator-Activated Receptors; D020033:Protein Isoforms