Procyanidins extracted from the lotus seedpod ameliorate scopolamine-induced memory impairment in mice.
The major purpose of this study was to determine the effect of procyanidins extracted from the lotus seedpod (LSPC) on the learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) in mice. The capacities of memory and learning were evaluated by the Morris water maze and the step-down avoidance test. LSPC (50, 100, 150 mg/kg BW, p.o.) significantly reversed scopolamine-induced learning and memory impairments in the Morris water maze test, as evaluated by shortened escape latency and swimming distance. In the step-down avoidance test, LSPC (50, 100, 150 mg/kg BW, p.o.) treatment significantly reduced the number of errors and shortened latency compared with that of scopolamine. In addition, LSPC was also found to inhibit acetyl cholinesterase (AChE) activity. These results of this study suggest that LSPC may play a useful role in the treatment of cognitive impairment caused by AD and aging.
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China.
Jiqu
J
Xu
Shuang
S
Rong
Bijun
B
Xie
Zhida
Z
Sun
Li
L
Zhang
Hailei
H
Wu
Ping
P
Yao
Yunjian
Y
Zhang
Liegang
L
Liu
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D000070116:Lotus / Q000737:chemistry*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D044945:Proanthocyanidins / Q000494:pharmacology*; D012601:Scopolamine / Q000009:adverse effects; D012639:Seeds / Q000737:chemistry
D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D044945:Proanthocyanidins; D012601:Scopolamine; D000110:Acetylcholinesterase