Does coasting, a procedure to avoid ovarian hyperstimulation syndrome, affect assisted reproduction cycle outcome?
OBJECTIVE
To evaluate the effects of coasting (withdrawing gonadotropin administration) on IVF outcome.


METHODS
Retrospective study.


METHODS
Department of Infertility of Zekai Tahir Burak Women's Health Research and Education Hospital.


METHODS
Ninety-four patients in whom coasting was applied (group 1). One control group consisted of 22 patients in whom coasting was not applied despite E(2) > 3000 pg/mL (group 2). A control group consisted of 111 normally responsive patients with peak E(2) < 3000 pg/mL level (group 3).


METHODS
When E(2) levels were greater than 3000 pg/mL in the presence of at least 20 follicles, each measuring >or=10 mm in diameter with >or=20% of them of diameter >or=15 mm, recombinant FSH administration was discontinued while GnRH agonist was maintained.


METHODS
Hormonal characteristics, IVF outcome, OHSS in coasted and noncoasted groups.


RESULTS
There was no statistically significant difference between number of total oocytes retrieved, metaphase II oocytes, and fertilization rates among the group 1 vs. group 2. However, the implantation rates and pregnancy rates were significantly higher in group 1 compared with group 2. Group 1 had more total oocytes retrieved and metaphase II oocytes compared with group 3. However, there was no significant difference in implantation and pregnancy rates between groups 1 and 3.


CONCLUSIONS
Coasting does not adversely affect assisted reproductive technology outcome and can be applied safely to high responder patients in ICSI.
Yilmaz
Nafiye
N
Department of Infertility, Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey. nafiyekarakas@hotmail.com
Uygur
Dilek
D
Ozgu
Emre
E
Batioglu
Sertac
S
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006062:Gonadotropins / Q000008:administration & dosage*; D006801:Humans; D054315:Oocyte Retrieval / Q000379:methods; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D010060:Ovulation / Q000187:drug effects* / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D006062:Gonadotropins