Significant increase in the apparent incidence of essential thrombocythemia related to new WHO diagnostic criteria: a population-based study.
To observe the effect of the new World Health Organization (WHO) criteria on the incidence of myeloproliferative neoplasms, we performed a retrospective study of a population-based registry in the Côte d'Or area, France, from 1980 to 2007. A total of 524 myeloproliferative neoplasms were registered for the 1980-2007 period, including 135 polycythemia vera, 308 essential thrombocythemia and 81 idiopathic myelofibroses. No change in the incidence of either polycythemia vera or idiopathic myelofibrosis was observed for the 2005-2007 period, compared to 1980-2004. On the contrary, a pronounced increase in the incidence of essential thrombocythemia was noted after 2005, mainly due to the use of JAK2 mutation screening and a lower threshold of platelet count. Our study confirms the relevance of the new WHO diagnostic criteria in allowing earlier diagnosis of essential thrombocythemia.
Girodon
François
F
Laboratoire d'Hématologie, Hôpital du Bocage, CHU de Dijon, Dijon, France. francois.girodon@chu-dijon.fr
Bonicelli
Gilles
G
Schaeffer
Céline
C
Mounier
Morgane
M
Carillo
Serge
S
Lafon
Ingrid
I
Carli
Paule Marie
PM
Janoray
Inès
I
Ferrant
Emmanuelle
E
Maynadié
Marc
M
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000175:diagnosis* / Q000453:epidemiology; D012042:Registries / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D013920:Thrombocythemia, Essential / Q000175:diagnosis* / Q000453:epidemiology; D014944:World Health Organization; D055815:Young Adult