[Evaluation of stomatognathic system in BRCA1 gene mutation carriers before and after prophylactic adnexectomy--part II: evaluation of stomatognathic system in BRCA1 gene mutation carriers after prophylactic adnexectomy].
BACKGROUND
Prophylactic adnexectomy is widely used for cancer risk reduction in women with BRCA1 gene mutations. Adnexectomy significantly reduces ovarian/ salpinx/peritoneum cancer risk to 5% and breast cancer risk to 30-40%. The aim of the study was evaluation of influence of prophylactic adnexectomy in BRCAI gene female mutation carriers on stomatognathic system.


METHODS
Thirty BRCA1 gene female mutation carriers aged 43-56 years, patients of the Hereditary Cancer Center in Szczecin, one year after prophylactic adnexectomy have been studied. The control group consisted the same patients, but had been studied before adnexectomy. Females with BRCA1 gene mutations have not received any hormone replacement therapy since the adnexectomy. They were divided into 2 subgroups: Y--women before menopause and Z--women aftermenopause. The complete dental exam was performed in all patients. Additionally, panoramic radiograms were performed.


RESULTS
Patients after prophylactic oophorectomy revealed higher rates of periodontal pockets 4-5 mm deep and increase of complaints such as: gingival bleeding following brushing, oral dryness and burning.


CONCLUSIONS
In conclusion, especially premenopausal women with BRCA1 gene mutations after surgical menopause should use short-term hormone replacement therapy to alleviate oral discomfort. Short-term hormone replacement therapy use does not negate the protective effect of prophylactic adnexectomy on breast cancer risk reduction in BRCA1 gene mutation carriers.
Chruściel-Nogalska
Małgorzata
M
Zakład Protetyki Stomatologicznej Pomorskiej Akademii Medycznej w Szczecinie al. Powstańców Wlkp. 72, 70-111 Szczecin.
D000328:Adult; D004245:DMF Index; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D005884:Gingival Hemorrhage / Q000453:epidemiology* / Q000517:prevention & control; D006579:Heterozygote; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010052:Ovariectomy / Q000706:statistics & numerical data*; D010514:Periodontal Pocket / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000517:prevention & control; D011859:Radiography