A p75(NTR) pivoting paradigm propels perspicacity.
The p75 neurotrophin receptor (p75(NTR)) is involved in numerous neuronal signaling paths but its fundamental signaling mechanisms are unknown. In this issue of Neuron, Vilar et al. show that p75NTR functions as a covalently crosslinked dimer to transduce NGF-induced signaling events.
Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, QC H3A 2B4, Canada. phil.barker@mcgill.ca
Philip A
PA
Barker
D000818:Animals; D003545:Cysteine / Q000378:metabolism; D006801:Humans; D020932:Nerve Growth Factor / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D054730:Protein Interaction Domains and Motifs / Q000502:physiology; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D020800:Receptor, Nerve Growth Factor; D020932:Nerve Growth Factor; D003545:Cysteine