Antibacterial endiandric acid derivatives from Beilschmiedia anacardioides.
Three endiandric acid derivatives, beilschmiedic acids A, B and C were isolated from the stem bark of Beilschmiedia anacardioides together with the known beta-sitosterol. Their structures were established by means of modern spectroscopic techniques. The relative configuration of compound 1 was determined by single crystal X-ray analysis. The antibacterial activities of compounds A,B,C were evaluated in vitro against five strains of microbes. Compound C showed strong activity against Bacillus subtilis, Micrococcus luteus and Streptococcus faecalis (MICs below 23 microM). This Compound was more active than the reference antibiotic ampicillin against B. subtilis and M. luteus.
Department of Organic Chemistry, University of Yaounde 1, PO Box 812, Yaoundé, Cameroon.
Jean Rodolphe
JR
Chouna
Pepin Alango
PA
Nkeng-Efouet
Bruno Ndjakou
BN
Lenta
Krishna Prasad
KP
Devkota
Beate
B
Neumann
Hans-Georg
HG
Stammler
Samuel Fon
SF
Kimbu
Norbert
N
Sewald
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D013293:Enterococcus faecalis / Q000187:drug effects; D019770:Lauraceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; C534861:endiandric acid