Phenotyping of cytochrome P450 3A enzyme in Gujarat population.
CYP3A isoforms account for about 30% of total hepatic P450s. Most statins have been accepted probes for CYP3A4. The metabolic ratio of atorvastatin/ortho-hydroxyatorvastatin showed a bimodal distribution with respect to metabolism of atorvastatin. These observations showed that the frequency of occurrence of the poor metabolizer phenotype is 2.4 % in the Gujarat subjects.
Jani
Ashutosh J
AJ
K. B. Institute of Pharmaceutical Education and Research. Sector 23, Gandhinagar, Gujarat -382023, India. janiashutosh@gmail.com
Rathnam
Shivprakash
S
Mehta
Anita A
AA
D000328:Adult; D000069059:Atorvastatin / Q000031:analogs & derivatives; D051544:Cytochrome P-450 CYP3A / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D006538:Heptanoic Acids / Q000378:metabolism*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000378:metabolism*; D007194:India; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D011758:Pyrroles / Q000378:metabolism*; D055815:Young Adult
C518963:2-hydroxyatorvastatin; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007527:Isoenzymes; D011758:Pyrroles; D000069059:Atorvastatin; D051544:Cytochrome P-450 CYP3A