Dual-energy X-ray absorptiometry is the method of choice to assess body composition in COPD.
OBJECTIVE
Mortality and morbidity in COPD have been related to reduced FEV1 as well as indices of body composition. Different techniques used to evaluate body composition may vary in accuracy, particularly in conditions with altered fluid balance such as COPD. We hypothesized that direct measurement of fat-free mass index (FFMI) by dual-energy X-ray absorptiometry (DEXA) would provide superior assessment of body composition in COPD.


METHODS
We measured body composition in 31 patients with COPD randomly selected from a teaching hospital clinic. To estimate total body water (TBW) and FFMI, skin-fold anthropometry, bioelectrical impedance analysis (BIA) with Schols and Lukaski equations as well as DEXA, total body potassium by whole-body gamma-counting (TBK) and in vivo neutron activation analysis were used. Combined body composition methods providing precise estimations of TBW were used for comparisons. Bland-Altman analyses, ANOVA and chi2-testing were used to examine data.


RESULTS
Mean BMI was 27.6 +/- 5.34 kg/m2 (mean +/- SD). Estimations of TBW were similar using Schols BIA or by using combined body composition methods. FFMI did not vary significantly between grades of COPD severity but was significantly different when assessed using DEXA and other methods. Calculated FFM hydration was significantly different from the fixed hydration factor used to calculate FFMI from BIA TBW (P < 0.05).


CONCLUSIONS
The Schols BIA method incorporates a fixed hydration factor that may lead to an erroneous estimation of FFMI with ensuing clinical implications. DEXA can be used to obtain accurate and comprehensive assessments of body composition and should be the preferred investigation in COPD.
Miller
Alistair
A
Department of Respiratory and Sleep Medicine, Monash University, Melbourne, Victoria, Australia.
Strauss
Boyd J
BJ
Mol
Stijn
S
Kyoong
Andrew
A
Holmes
Peter H
PH
Finlay
Paul
P
Bardin
Philip G
PG
Guy
Paul
P
D015502:Absorptiometry, Photon / Q000379:methods*; D000368:Aged; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D001834:Body Water; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012885:Skinfold Thickness