[Histological types and prognostic factors in colorectal cancer].
Medullary carcinoma and serrated adenocarcinoma are two variants of colon cancer which are associated to particular pathways. Medullary carcinoma is invariably associated with MSI while serrated adenocarcinoma is characterized by excess of methylation. TNM classification and the tumoral grade are still the most important prognostic factors. Several parameters including morphological criteria, molecular features or immunohistochemical markers seem to be relevant but none of them are today used in clinical practice. A more accurate approach of the evaluation of these additional parameters should improve their prognosis values. double dagger.
Selves
Janick
J
Inserm U563, CPTP, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France. janick.selves@toulouse.inserm.fr
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D018276:Carcinoma, Medullary / Q000235:genetics / Q000473:pathology; D015179:Colorectal Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology*; D053843:DNA Mismatch Repair; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007633:Keratins / Q000032:analysis; D009361:Neoplasm Invasiveness; D011379:Prognosis
D007633:Keratins