[Chromosomal aberrations upon isolated and combined exposures to chemical substances and ionizing irradiation].
The partial summation of biological effects evaluated by the anaphasic chromosomal aberration test in the bone marrow karyocytes of mice was determined when the animals were concurrently exposed to chemical substances (acetone, acetaldehyde, ammonia, and ethanol) at low concentrations and gamma-irradiation in a total dose of 30 Gy. Qualitative analysis of chromosomal aberrations in the karyocytes of the bone marrow (ponses, fragments) has indicated that upon combined exposure of the animals to the chemical substances and gamma-irradiation, the chemical factor is dominant since upon combined radiochemical exposure, the number of chromosomal aberration increases mainly at the expense of fragments (91.2%), as does upon isolated exposure to chemical substances (96.4%).
Barantseva
M Iu
MIu
Mukhamedieva
L N
LN
Fedorenko
B S
BS
Vorozhtsova
S V
SV
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000139:chemically induced* / Q000528:radiation effects*; D033481:Chromosomes, Mammalian / Q000000981:diagnostic imaging* / Q000187:drug effects*; D004195:Disease Models, Animal; D005720:Gamma Rays / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D011859:Radiography