[Protection against uterine cervical cancer by HPV vaccines].
Research literature has definitively shown HPV to be a necessary cause of cervical cancer. HPV is highly prevalent in sexually active populations and its natural history is now traceable thanks to recent advances in technology. HPV-like particle can now be synthesized and assembled in vitro to constitute the major virion protein L1, and this technology has been exploited to produce HPV-L1-VLP vaccines. Now, HPV-related diseases can thus be prevented by commercially available HPV prophylactic vaccines such as Gardasil (recombinant HPV genotype 6/11/16/18) and Cervarix (recombinant HPV genotype 16/18). These advances have dramatically changed the administration of cervical cancer screening programs.
Inoue
Masaki
M
Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University. masaki-i@med.kanazawa-u.ac.jp
D005260:Female; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D006801:Humans; D030361:Papillomavirus Infections / Q000517:prevention & control*; D053918:Papillomavirus Vaccines; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control*
D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D053918:Papillomavirus Vaccines; C510352:human papillomavirus vaccine, L1 type 16, 18