Stress-induced hyperthermia and infection-induced fever: two of a kind?
Stress exposure activates the autonomic nervous system and leads to a body temperature increase (stress-induced hyperthermia, SIH). On the other hand, an activation of the immune system in response to an infection leads to fever. Both processes increase body temperature, and the relation between SIH and infection-induced fever has been subject to debate. It is not clear whether SIH is a form of fever, or whether both processes are more or less distinct. We therefore examined the relation between SIH and infection-induced fever by looking at the effects of a GABA(A) receptor agonist (diazepam) and a prostaglandin-synthesis blocking drug (acetylsalicylic acid, aspirin) on both the SIH response and fever in rats and mice. The present study shows that the benzodiazepine diazepam but not the prostaglandin-synthesis blocking drug aspirin dose-dependently attenuated the SIH response in both rats and mice. In contrast, aspirin reduced both LPS- and IL-1beta induced fever, whereas diazepam had little effect on these fever states. Altogether, our findings support the hypothesis that stress-induced hyperthermia and infection-induced fever are two distinct processes mediated largely by different neurobiological mechanisms.
Dept. of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS) and Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands. c.h.vinkers@uu.nl
Christiaan H
CH
Vinkers
Lucianne
L
Groenink
Meg J V
MJ
van Bogaert
Koen G C
KG
Westphal
Cor J
CJ
Kalkman
Ruud
R
van Oorschot
Ronald S
RS
Oosting
Berend
B
Olivier
S Mechiel
SM
Korte
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004567:Electrodes, Implanted; D005334:Fever / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology*; D018755:GABA Agonists / Q000494:pharmacology; D058785:GABA-A Receptor Agonists; D007239:Infections / Q000150:complications* / Q000503:physiopathology*; D053583:Interleukin-1beta; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology*; D013686:Telemetry
D018755:GABA Agonists; D058785:GABA-A Receptor Agonists; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D011448:Prostaglandin Antagonists; D003975:Diazepam; D001241:Aspirin