[Drug discovery based on classic natural products].
We think the strategy of classic natural product-based drug discovery will be an effective way for us to develop new drugs with independent intellectual property. The strategy includes: to study the molecular mechanism of action of classic natural product with chemical genetics and chemical biology approaches firstly; then establish the proper in vitro bioassay or bioassay system based on its molecular mechanism for their pharmacodynamic evaluation; finally, study their structure-activity, structure-toxicity and structure-ADME properties with medicinal chemistry.
Hu
Li-hong
LH
Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. simmhulh@mail.shcnc.ac.cn
Xu
Ji-qing
JQ
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000494:pharmacology; D001599:Berberine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002166:Camptothecin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D055808:Drug Discovery; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000138:chemical synthesis / Q000494:pharmacology; D014747:Vinblastine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D000094062:Betulinic Acid
D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products; D007004:Hypoglycemic Agents; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D001599:Berberine; D014747:Vinblastine; D009828:Oleanolic Acid; D002166:Camptothecin; D000094062:Betulinic Acid