Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west Russia.
OBJECTIVE
To estimate the prevalence of the lactase non-persistent genotype (C/C-13910) in a northern Russian population in accordance with ethnicity, and to evaluate self-reported milk consumption depending on lactase activity.


METHODS
Blood samples for genotyping lactase activity, defining the C/T-13910 variant by polymerase chain reaction, and direct sequencing were taken from 231 medical students of Russian origin aged 17-26 years. We analyzed milk product consumption by questionnaire which was specially designed for the estimation of milk consumption and abdominal complaints.


RESULTS
We found that the prevalence of the C/C-13190 genotype in the northern Russian population was 35.6%. The other genotypes nearby C/T-13910 and associated with lactase activity were not present in the study population. The consumption of milk among people with the non-persistent genotype tended to be lower than among the lactose tolerant subjects, but was not statistically significant.


CONCLUSIONS
An investigation of the lactase persistent genotype in a northern Russian population has not been performed before. The genotype did not affect the consumption of milk products in this population which could be explained by low consumption of milk products among the entire study population.
Khabarova
Yulia
Y
Department of Family Medicine, Northern State Medical University, Arkhangelsk, Russia. yuliakaterina@rambler.ru
Torniainen
Suvi-Tuulia
ST
Nurmi
Hanna-Anneli
HA
Järvelä
Irma-Elisabet
IE
Isokoski
Mauri-Kullervo
MK
Mattila
Kari-Juhani Mattila
KJ
D000293:Adolescent; D000328:Adult; D000818:Animals; D004032:Diet; D005838:Genotype; D006801:Humans; D043322:Lactase / Q000235:genetics / Q000378:metabolism; D007787:Lactose Intolerance / Q000201:enzymology / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D008892:Milk; D011897:Random Allocation; D012426:Russia; D011795:Surveys and Questionnaires; D055815:Young Adult
D043322:Lactase