Non-alcoholic steatohepatitis with normal aminotransferase values.
OBJECTIVE
To investigate the aspects of liver histology in patients with non-alcoholic steatohepatitis (NASH) who had normal aminotransferase levels.


METHODS
Thirty-four patients diagnosed with liver steatosis by ultrasonographic examination participated in the study. We compared all non-alcoholic fatty liver disease and NASH cases, according to aminotransferase level, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio and presence of metabolic syndrome.


RESULTS
Sixteen of 25 patients with high aminotransferase levels were diagnosed with NASH and nine with simple fatty liver according to liver histology. Among the nine patients with normal aminotransferase levels, seven had NASH and two had simple fatty liver. The patients with normal and high liver enzyme levels had almost the same prevalence of NASH and metabolic syndrome. Liver histology did not reveal any difference according to aminotransferase levels and AST/ALT ratio.


CONCLUSIONS
Aminotransferase levels and AST/ALT ratio do not seem to be reliable predictors for NASH. Despite numerous non-invasive biomarkers, all patients with fatty liver should undergo liver biopsy.
Department of Gastroenterology, Yozgat State Hospital, Yozgat, Turkey. huslusoy.23@hotmail.com
Hüseyin Saadettin
HS
Uslusoy
Selim Giray
SG
Nak
Macit
M
Gülten
Zeynep
Z
Biyikli
D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism*; D000886:Anthropometry; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001706:Biopsy; D005234:Fatty Liver / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D014463:Ultrasonography
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase