[Drug permeability through buccal mucosa].
To investigate the effects of physicochemical properties of drug on its permeability through buccal mucosa.



Benzoic acid, caffeine and hydrocortisone were selected as model drugs and their permeability coefficients through isolated porcine buccal mucosa were determined.



The permeability coefficients of benzoic acid, caffeine and hydrocortisone through isolated porcine buccal mucosa were (1.01 x 10(-4)+/-1.64 x 10(-5))cm.s(-1)ì(2.75 x 10(-5)+/-1.79 x 10(-6))cm.s(-1) and (2.49 x 10(-5)+/-6.32 x 10(-6))cm.s(-1), which were 14,989 and 389 times as those through human skin, respectively.



The permeability of drugs through buccal mucosa seems to be much better than that through human skin.
Fu
Xu-chun
XC
Department of Pharmacy, Zhejiang University City College, Hangzhou 310015 China.
Pan
Xiao-jiao
XJ
D000818:Animals; D019817:Benzoic Acid / Q000493:pharmacokinetics*; D002110:Caffeine / Q000493:pharmacokinetics*; D006854:Hydrocortisone / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D009061:Mouth Mucosa / Q000378:metabolism*; D010539:Permeability / Q000187:drug effects; D013552:Swine
D002110:Caffeine; D019817:Benzoic Acid; D006854:Hydrocortisone