Reduced levels of interleukin-1 receptor antagonist in the cerebrospinal fluid in patients with West syndrome.
We measured the levels of pro- and anti-inflammatory cytokines in the cerebrospinal fluid (CSF) of 24 patients with West syndrome to clarify whether inflammatory cytokines were involved in the pathophysiology of West syndrome. There was no significant elevation of any of the three pro-inflammatory cytokines, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, in patients with West syndrome as compared with those in controls. However, level of anti-inflammatory cytokine, IL-1 receptor antagonist was significantly decreased in the CSF of patients with West syndrome. Further study is needed to elucidate whether an immune system disturbance is involved in the pathophysiology of West syndrome.
Department of Pediatrics, Tohoku University School of Medicine, Sendai 980-8574, Japan. khaginoya@silk.ocn.ne.jp
Kazuhiro
K
Haginoya
Rie
R
Noguchi
Yajuan
Y
Zhao
Mitsutoshi
M
Munakata
Hiroyuki
H
Yokoyama
Soichiro
S
Tanaka
Naomi
N
Hino-Fukuyo
Mitsugu
M
Uematsu
Katsuya
K
Yamamoto
Masaru
M
Takayanagi
Kazuie
K
Iinuma
Shigeru
S
Tsuchiya
D016207:Cytokines / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007223:Infant; D053590:Interleukin 1 Receptor Antagonist Protein / Q000134:cerebrospinal fluid*; D053583:Interleukin-1beta / Q000134:cerebrospinal fluid; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D008297:Male; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid; D013036:Spasms, Infantile / Q000134:cerebrospinal fluid*; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid
D016207:Cytokines; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha