The calcium/NFAT pathway: role in development and function of regulatory T cells.
Calcium signals are essential for diverse cellular functions in the immune system. Sustained Ca(2+) entry is necessary for complete and long-lasting activation of calcineurin/NFAT pathways. A growing number of studies have emphasized that Ca(2+)/calcineurin/NFAT pathway is crucial for both development and function of regulatory T cells.
Department of Pathology, Harvard Medical School and Immune Disease Institute, Boston, MA 02115, USA. ohora.gcoe@tmd.ac.jp
Masatsugu
M
Oh-hora
Anjana
A
Rao
D019703:Calcineurin / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D050778:NFATC Transcription Factors / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
D050778:NFATC Transcription Factors; D019703:Calcineurin; D002118:Calcium