Enantioselective organocatalytic Michael addition of aldehydes to beta-nitrostyrenes.
The utility of C(2)-symmetric bipiperidine and bimorpholine derivatives as organocatalysts in the Michael addition of enamine intermediates formed from aldehydes to nitroolefins has been demonstrated. The best results were obtained when the reaction was run in the presence of (2R,2'R)-N-iPr-bipiperidine. The products were formed via an enamine intermediate with high diastereo- and enantioselectivity with relatively short reaction times.
Laars
Marju
M
Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.
Ausmees
Kerti
K
Uudsemaa
Merle
M
Tamm
Toomas
T
Kanger
Tõnis
T
Lopp
Margus
M