[Systemic inflammation and atherosclerosis of common carotid arteries in patients with chronic obstructive pulmonary disease].
This work had the aim to study effect of systemic inflammation in patients with COPD and COPD with arterial hypertension (AH) based on the state of endothelium and the degree of atherosclerosis of common carotid arteries. The study included 51 men (mean age 50.9 +/- 3 yr) 20 of whom (mean age 54.5 +/- 13.2 yr) had grade I-II COPD (GOLD, 2006) and 1-2 grade AH (WHO, 1999). The patients were allocated to 2 groups, one comprising 11 subjects with isolated AH (mean age 47.5 +/- 8.4 yr) the other 10 men with isolated COPD (mean age 51.8 +/- 4.6 yr). The control group included 10 men (mean age 49.6 +/- 5.3 yr). IMT, C-reactive protein, and blood lipid spectrum were determined in all the patients. Patients with COPD with and without AH developed atherosclerosis of common carotid arteries caused by persistent systemic inflammation. Increased serum C-reactive protein and IMT in patients of the two groups contributed to the initiation and progress of atherosclerosis of common carotid arteries.
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Chicherina
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Miliutina
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002340:Carotid Artery Diseases / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D012307:Risk Factors; D014463:Ultrasonography; D014661:Vasoconstriction
D015415:Biomarkers; D008055:Lipids; D002097:C-Reactive Protein