Molds: hyalohyphomycosis, phaeohyphomycosis, and zygomycosis.
Emerging fungi previously thought to be nonpathogenic are now recognized as playing a significant role in the increased incidence of invasive fungal disease. This change in the epidemiology of invasive fungal infections (IFIs) has occurred in the era of aggressive new therapies for hematopoietic stem cell transplantation and other malignancies that lead to profound immunosuppression for longer durations and has extended the survival of these critically ill patients. The significant morbidity and mortality associated with these infections is not only related to the host populations but to delayed recognition and diagnosis and high rates of resistance in some of these emerging pathogens to standard antifungal therapies.
Division of Infectious Diseases, Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA. naggi001@mc.duke.edu
Susanna
S
Naggie
John R
JR
Perfect
D006801:Humans; D009181:Mycoses / Q000175:diagnosis; D020096:Zygomycosis