Differentiation and function of pro-inflammatory Th17 cells.
After activation, CD4+ helper T (Th) cells differentiate into cytokine-secreting effector subsets. A novel subset of CD4+ helper T (Th) cells that produce two related cytokines IL-17 and IL-17F has been recently identified and shown to play critical function in inflammation and autoimmunity. Here I summarize recent work by us as well as other investigators in understanding the transcriptional regulation of Th17-cell differentiation, their developmental relationship with regulatory T cells and the function of IL-17 and IL-17F in vivo.
Dong
Chen
C
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA. cdong@mdanderson.org
D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D007249:Inflammation / Q000276:immunology*; D020381:Interleukin-17 / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000276:immunology*
D020381:Interleukin-17