Microtubule assembly, organization and dynamics in axons and dendrites.
During the past decade enormous advances have been made in our understanding of the basic molecular machinery that is involved in the development of neuronal polarity. Far from being mere structural elements, microtubules are emerging as key determinants of neuronal polarity. Here we review the current understanding of the regulation of microtubule assembly, organization and dynamics in axons and dendrites. These studies provide new insight into microtubules' function in neuronal development and their potential contribution to plasticity.
Laboratorio de Neurobiología Celular y Molecular, Instituto Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET), Friuli 2434, 5016 Córdoba, Argentina.
Cecilia
C
Conde
Alfredo
A
Cáceres
D000818:Animals; D001369:Axons / Q000502:physiology*; D016764:Cell Polarity; D003712:Dendrites / Q000502:physiology*; D008870:Microtubules / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D017711:Nonlinear Dynamics; D013569:Synapses / Q000502:physiology