Occurrence of sesquiterpene derivatives in Scleria striatonux de wild (Cyperaceae).
Scleria striatonux (Cyperaceae), a spice traditionally used in Cameroon, displayed an antiplasmodial activity. Two new sesquiterpenes, 1 (sclerienone A) and 2 (sclerienone B), have subsequently been isolated from the methylene chloride/methanol extract of the rhizome. Their separation involved a combination of methods including repeated silica gel open column chromatography, Sephadex LH-20 and semi-preparative HPLC. Structure elucidation was achieved by means of chemical tests and extensive spectral studies.
Nyongbela
Kennedy
K
Laboratoire de Pharmacognosie et Phytochimie, Ecole de Pharmacie Genève, Université de Genève, Quai Ansermet 30, 1211 Genève 4, Switzerland.
Ndjoko
Karine Ioset
KI
Brun
Reto
R
Wittlin
Sergio
S
Mbah
James
J
Makolo
Felix
F
Akam
Marc
M
Wirmum
Claire
C
Efange
Simon
S
Hostettmann
Kurt
K
D000818:Animals; D029785:Cyperaceae / Q000737:chemistry*; D015394:Molecular Structure; D010961:Plasmodium / Q000187:drug effects; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology
D012717:Sesquiterpenes; C541201:sclerienone A; C541202:sclerienone B