ApoE epsilon4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
A previous report found an association between ApoE isoforms and postictal confusion in medically intractable temporal lobe epilepsy (TLE). We performed a molecular epidemiology study in an independent sample of 77 TLE patients. We failed to replicate the original allelic association between ApoE epsilon4 allele and postictal confusion in our population (chi(2)=1.67; d.f.=1; p=0.2). Thus, the association between ApoE epsilon4 allele and postictal confusion still needs to be fully investigated in different and independent populations.
Centro de Epilepsia, División Neurología, Hospital Ramos Mejía, CEFYBO, CONICET, Buenos Aires, Argentina. marcelokauffman@marcelokauffman.info
Marcelo Andrés
MA
Kauffman
Nahuel
N
Pereira-de-Silva
Damián
D
Consalvo
Silvia
S
Kochen
D001057:Apolipoproteins E / Q000235:genetics*; D001118:Argentina / Q000453:epidemiology; D003221:Confusion / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012598:Sclerosis; D012640:Seizures / Q000523:psychology*
D001057:Apolipoproteins E; D004247:DNA