[Efficacy and side-effects of the botulinum toxin A treatment in patients with focal dystonia].
An aim of the study was to determine side-effects of disport, the botulinum toxin A (BTA), in the treatment of patients with spasmodic torticollis (ST) and blepharospasm (BS). More than 800 injections of BTA to patients with ST and 110 - to patients with BS have been performed for 6-years period. Side-effects are specified as follows: 1) autonomic reactions observed in women with increased anxiety and signs of autonomic dysfunction (47,5%) patients with ST), with most marked symptoms in the first injection and their further decreasing; 2) local side-effects related with errors in dose adjustment, injection technique (37,3% patients with ST and 59,5% patients with BS); 3) the smallest group of side-effects not related to the doctor's experience and adequate psychological preparation of the patient for manipulation (myasthenia-myopathia syndrome after the BTA therapy).
S A
SA
Likhachev
Iu N
IuN
Rushkevich
T N
TN
Chernukha
E V
EV
Veevnik
D001764:Blepharospasm / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D020821:Dystonic Disorders / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007273:Injections, Intramuscular; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D012189:Retrospective Studies; D013997:Time Factors; D014103:Torticollis / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D016896:Treatment Outcome
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A