Kinetics of self-immolation: faster signal relay over a longer linear distance?
A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, USA.
Ho Yong
HY
Lee
Xuan
X
Jiang
Dongwhan
D
Lee