Chiral recognition of hybrid metal oxide by peptides.
Resolution of gram quantities of a subtly chiral polyoxometalate (POM; the chirality originates from substitution of one metal in the nanosized framework) is possible by reaction with small peptides. Functionalizable acyl polyoxotungstate (TBA)(6)[alpha(1)-P(2)W(17)O(61){SnCH(2)CH(2)C(=O)}] (see picture) can be resolved by kinetic resolution. This approach paves the way for applications of chiral POMs ranging from asymmetric catalysis to their bioactivity.
UPMC Univ Paris 06, Institut Parisien de Chimie Moléculaire (UMR CNRS 7201), C. 229, 4 place Jussieu, 75005 Paris, France.
Kévin
K
Micoine
Bernold
B
Hasenknopf
Serge
S
Thorimbert
Emmanuel
E
Lacôte
Max
M
Malacria
D053758:Nanoparticles / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013237:Stereoisomerism; D017973:Tungsten Compounds / Q000737:chemistry*
D010087:Oxides; D010455:Peptides; D011108:Polymers; D017973:Tungsten Compounds