[Genetic determination of fast plasma glucose concentration and correlation with anthropometric indices].
OBJECTIVE
To study the genetic determination of fast plasma glucose (FPG) and correlation with its potential correlated traits, anthropometric measures and blood pressure.


METHODS
Two hundred and eighteen Type 2 diabetes mellitus (T2DM) pedigrees composed of 1383 Chinese Han individuals residing in the East and South-East China were analyzed. Univariate variance decomposition analyses were used to estimate the narrow-sense heritability (h(2)) of FPG, anthropometric indices and blood pressure, and bivariate quantitative genetic analyses were used to estimate the genetic and environmental correlations between FPG and anthropometric measures or blood pressure.


RESULTS
We found that FPG, blood pressure and all anthropometric indices except for waist to hip ratio were under significant genetic determination, and the h(2) was from 0.28 to 0.43. We did not find significant genetic and environmental correlation between FPG and anthropometric indices and blood pressure.


CONCLUSIONS
The present study demonstrated that T2DM, obesity and hypertension were controlled by some genetic factors, and FPG shares little common genetic and environmental factors with obesity-related anthropometric indices and blood pressure in our Chinese sample population.
Department of Endocrinology, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Wei-xia
WX
Jian
Qing
Q
Su
Min
M
Luo
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D044466:Asian People / Q000235:genetics; D001786:Blood Glucose / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics; D002681:China / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005215:Fasting / Q000097:blood* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D005947:Glucose / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D012307:Risk Factors; D049629:Waist-Hip Ratio; D055815:Young Adult
D001786:Blood Glucose; D005947:Glucose