Altered pulmonary function in children with asthma associated with highway traffic near residence.
Cross-sectional analyses were conducted to evaluate the effects of exposure to highway traffic on pulmonary function in Fresno, California. Traffic and spirometry data were available for 214 children (enrollment ages six to 11 years). Multiple linear regression was used to evaluate the relations between pulmonary function and traffic parameters. Heavy-duty vehicle count was used as a surrogate measure for diesel-related exposures. Pulmonary function was non-significantly associated with longer distance-to-road and non-significantly associated with higher traffic intensity. Evaluation of effect modification by FEF(25-75)/FVC (a measure of intrinsic airway size) showed that all pulmonary function measures of flow were significantly inversely related to a traffic metric that incorporates traffic intensity and roadway proximity. The results indicate that residence proximity to highway traffic is associated with lower pulmonary function among children with asthma, and smaller airway size is an important modifier of the effect of traffic exposure on pulmonary function and a marker of increased susceptibility.
Margolis
Helene G
HG
Division of General Medicine, Department of Internal Medicine, School of Medicine, University of California, Davis, CA, USA.
Mann
Jennifer K
JK
Lurmann
Frederick W
FW
Mortimer
Kathleen M
KM
Balmes
John R
JR
Hammond
S Katharine
SK
Tager
Ira B
IB
D001249:Asthma / Q000503:physiopathology*; D002648:Child; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D012044:Regression Analysis; D012111:Residence Characteristics; D012129:Respiratory Function Tests; D001335:Vehicle Emissions / Q000633:toxicity*
D001335:Vehicle Emissions