Lack of complex I is associated with oncocytic thyroid tumours.
Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue.
Department of Paediatrics, University Hospital Salzburg, Paracelsus Medical University, Muellner Hauptstrasse 48, A-5020 Salzburg, Austria.
F A
FA
Zimmermann
J A
JA
Mayr
D
D
Neureiter
R
R
Feichtinger
B
B
Alinger
N D
ND
Jones
W
W
Eder
W
W
Sperl
B
B
Kofler
D000236:Adenoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D004272:DNA, Mitochondrial / Q000235:genetics; D042967:Electron Transport Complex I / Q000172:deficiency* / Q000235:genetics; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D016678:Genome; D006042:Goiter / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D006801:Humans; D006980:Hyperthyroidism / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D008928:Mitochondria / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D010085:Oxidative Phosphorylation; D013964:Thyroid Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology
D004272:DNA, Mitochondrial; D042967:Electron Transport Complex I