[The influence of mexidol on post-radiation recovery of hemopoietic system].
The purpose of this work was the study in experiments on mice of influence of mexidol on current and outcome of an acute radiation sickness. At an irradiation in a dose 6.0 Gy was studied a condition of hemopoietic system, and at an irradiation in a dose 7.7 Gy a survival rate of animals. In all experiments mexidol applied in two circuits of introduction. The first circuit - once per day with 1 for 8 day after the irradiation. The second circuit of introduction: with 1 for 5 day--two times per day and on 6-8 day once per day. The introduction of mexidol after influence of ionizing radiation reduces a degree of radiative defeat of bone marrow and promotes the activization post-radiation recovery of an erythropoiesis, neutrophilopoiesis in an bone marrow and lymphopoiesis in a thymus gland. This effect is more expressed at introduction mexidol two times per day. At influence of ionizing radiation in a dose 7.7 Gy has survived 56% of mice. The introduction of mexidol two times per day was enlarged by survival rate animal up to 94%. The application of mexidol once per day essentially did not influence on the survival rate of the irradiated mice. The received data show, that the introduction of mexidol with 1 for 8 day after an irradiation, frameing a favorable metabolic background, stimulates recovery processes in hemopoietic system, reduces gravity of a acute radiation sickness and by that enlarges the survival rate of the irradiated animals.
Moroz
B B
BB
Deshevoĭ
Iu B
IuB
Sukoian
G V
GV
Voronina
T A
TA
Lyrshchikova
A V
AV
Lebedev
V G
VG
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D004307:Dose-Response Relationship, Radiation; D004920:Erythropoiesis / Q000187:drug effects; D005720:Gamma Rays; D006413:Hematopoietic System / Q000187:drug effects* / Q000528:radiation effects*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D019891:Leukopoiesis / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010847:Picolines / Q000008:administration & dosage*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000503:physiopathology
D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate