Effects of physical training on serum and pituitary growth hormone contents in diabetic rats.
The present study investigated the effects of moderate physical training on some of the parameters in the GH-IGF axis in experimental diabetic rats. Male Wistar rats were allocated into the following groups: sedentary control, trained control, sedentary diabetic, trained diabetic. Diabetes was induced by alloxan (32 mg/kg, b.w. iv). The physical training protocol consisted of 1 h swimming session/day, 5 days/week for 8 weeks supporting a load corresponding to 90% of maximal lactate steady state. After the experimental period, blood was collected to measure serum glucose, insulin, triglycerides, albumin, insulin-like growth factors-I (IGF-I), and growth hormone (GH). Pituitary gland was removed for GH quantification. Diabetes increased blood glucose and triglycerides and decreased insulin, IGF-I, serum and pituitary GH. Physical training decreased glucose and triglycerides, and also counteracted the reduction of serum IGF-I in diabetic rats. In conclusion, physical training recovered serum IGF-I showing no alteration of serum or pituitary GH levels.
Department of Physical Education, São Paulo State University (UNESP), Avenida 24A no. 1515, Caixa Postal 199, Bela Vista, Rio Claro, São Paulo, CEP 13506-900, Brazil. zecuriacos@terra.com.br
José Alexandre Curiacos
JA
de Almeida Leme
Michel Barbosa
MB
de Araújo
Leandro Pereira
LP
de Moura
Ricardo José
RJ
Gomes
Rodrigo Ferreira
RF
de Moura
Gustavo Puggina
GP
Rogatto
Maria Alice Rostom
MA
de Mello
Eliete
E
Luciano
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000378:metabolism*; D013006:Growth Hormone / Q000097:blood* / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone