Six-month angiographic study of immediate autologous bone marrow mononuclear cell implantation on acute anterior wall myocardial infarction using a mini-pig model.
This study investigated six-month angiographic results of autologous bone marrow mononuclear cell (BMMNC) transplantation immediately following acute myocardial infarction (AMI) in a mini-pig model.AMI was induced by left anterior descending artery ligation. Twenty-four mini-pigs were equally divided into group 1 [AMI plus saline injection in infarcted area (IA)], group 2 (AMI plus BMMNC transplantation into non-IA), group 3 (AMI plus BMMNC implantation into IA), and group 4 (sham control). One-week cultured BMMNCs (3.0 x 10(7)) were immediately transplanted following AMI induction. Angiographic studies over 6 months demonstrated that mitral regurgitation (MR) was lower in groups 3 and 4 than in groups 1 and 2 (all P < 0.01). Wall motion scores and left ventricular ejection fraction (LVEF) were higher in groups 3 and 4 than in groups 1 and 2 (all P < 0.05). Collateral circulation was higher in group 3 than in groups 1 and 2 ( P < 0.01). The wall thickness of the IA was higher, whereas the heart weight was lower in group 3 than in groups 1 and 2 (all P < 0.01).Immediate autologous BMMNC transplantation into IA is superior to saline-treated only or BMMNC transplantation into non-IA following AMI for reducing MR and improving LVEF.
Department of Cardiovascular Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Taiwan, Republic of China.
Jiunn-Jye
JJ
Sheu
Chun-Man
CM
Yuen
Cheuk-Kwan
CK
Sun
Li-Teh
LT
Chang
Chia-Hung
CH
Yen
Chiang-Hua
CH
Chiang
Sheung-Fat
SF
Ko
Sung-Nan
SN
Pei
Sarah
S
Chua
Anuj
A
Bhasin
Chiung-Jen
CJ
Wu
Hon-Kan
HK
Yip
D000465:Algorithms; D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods*; D017023:Coronary Angiography; D004195:Disease Models, Animal; D009000:Monocytes / Q000637:transplantation*; D009203:Myocardial Infarction / Q000601:surgery*; D013552:Swine; D013556:Swine, Miniature; D014182:Transplantation, Autologous; D016277:Ventricular Function, Left