Preparation, characterization and in vitro evaluation of 50% enantiomeric excess bupivacaine (S75-R25)-loaded microspheres.
OBJECTIVE
Microspheres can be used as a controlled delivery system to prolong the duration of action of local anesthetics. The objective of this study was the preparation, characterization and analysis of the in vitro release of 50% enantiomeric excess bupivacaine (S75-R25)-loaded microspheres.


METHODS
Microspheres were prepared using the copolymer of polylactide-co-glycolic acid by the spray-dryed method.


RESULTS
Characterization of microspheres regarding their size and content were similar to the theoretical values. The in vitro release demonstrated a biphasic pattern.


CONCLUSIONS
Manufacturing of 50% enantiomeric excess bupivacaine-loaded microspheres by the spray-dryed method with results similar to bupivacaine-loaded microspheres can be done.
Tanaka
Pedro Paulo
PP
CET/SBA do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR. tanaka@ufpr.br
Estèbe
Jean Pierre
JP
Campos
Richard
R
Chevanne
François
F
Le Corre
Pascal
P
Tenório
Sérgio Bernardo
SB
Torres
Maria Fernanda
MF
D000779:Anesthetics, Local / Q000008:administration & dosage; D002045:Bupivacaine / Q000008:administration & dosage; D008863:Microspheres; D013678:Technology, Pharmaceutical
D000779:Anesthetics, Local; D002045:Bupivacaine