Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies.
Adiponectin is a secretory protein predominantly expressed by adipocytes and released at a high rate into circulation. The ease with which the levels of adiponectin can be measured owing to its high abundance, small diurnal variation and high stability in plasma have made it a popular target for measurements in many clinical studies. It has emerged as a valuable biomarker for insulin sensitivity, cardiovascular risk and inflammation. However, adiponectin levels have been measured in many additional disease states. Preclinical studies not only have implicated adiponectin as an outstanding biomarker but also have demonstrated direct cardio-protective and insulin-sensitizing properties to be associated with the protein. Adiponectin might, therefore, be a viable protein therapeutic that could be supplied in a recombinant form in the context of type 2 diabetes and cardiovascular disease. However, the high abundance, complex tertiary and quaternary structure and rapid turnover might make chronic administration of the protein rather challenging.
Shetty
Shoba
S
Touchstone Diabetes Center, Departments of Internal Medicine and Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8549, USA.
Kusminski
Christine M
CM
Scherer
Philipp E
PE
D052242:Adiponectin / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D016503:Drug Delivery Systems; D055808:Drug Discovery; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology; D007674:Kidney Diseases / Q000378:metabolism; D008958:Models, Molecular; D010012:Osteogenesis / Q000502:physiology; D020033:Protein Isoforms / Q000378:metabolism; D011994:Recombinant Proteins / Q000627:therapeutic use
D052242:Adiponectin; D015415:Biomarkers; D020033:Protein Isoforms; D011994:Recombinant Proteins; D005947:Glucose