Fungal cytoskeleton dysfunction or immune activation triggered by beta-glucan synthase inhibitors: potential mechanisms for the prolonged antifungal activity of echinocandins.
Safdar
Amar
A
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. asafdar@mdanderson.org
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000187:drug effects; D003599:Cytoskeleton / Q000187:drug effects*; D054714:Echinocandins / Q000494:pharmacology*; D005656:Fungal Proteins / Q000276:immunology / Q000378:metabolism*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D008954:Models, Biological; D047071:beta-Glucans / Q000276:immunology* / Q000378:metabolism
D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D047071:beta-Glucans; D005964:Glucosyltransferases; C020570:1,3-beta-glucan synthase