Changes in lung function in young cystic fibrosis patients between two courses of intravenous antibiotics against Pseudomonas aeruginosa.
OBJECTIVE
Repeated intravenous antibiotic therapy (IVAT) against chronic pulmonary infection with Pseudomonas aeruginosa is often necessary in cystic fibrosis patients (CF). The aim of this study was to monitor kinetics of degradation of pulmonary and nutritional status after IVAT in CF patients.


METHODS
Lung function, nutritional status and physical activity (PA) were measured for 21 CF patients (mean +/- SD age, 16 +/- 1.9 years; 9 boys) who were chronically colonized by P. aeruginosa. Each parameter was measured every 15 days during 3-6 months.


RESULTS
Nutritional status as well as PA did not change in the interval of 2 IVAT. In contrary, lung function worsened with a decrease of -14.6% of the FEV(1) (P < 0.05).


CONCLUSIONS
In CF, there is a progressive decrease in lung function without any evident deterioration of nutritional status and PA between two IVAT.
EA 3925, Université Lille 2 Droit et Santé & Division of Gastroenterology, Hepatology and Nutrition, Cystic Fibrosis Center, Lille, France. l-beghin@chru-lille.fr
Laurent
L
Béghin
Laurent
L
Michaud
Guy-André
GA
Loeuille
Nathalie
N
Wizla-Derambure
Hocine
H
Sayah
Anne
A
Sardet
Caroline
C
Thumerelle
Antoine
A
Deschildre
Dominique
D
Turck
Frédéric
F
Gottrand
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002648:Child; D003550:Cystic Fibrosis / Q000382:microbiology / Q000503:physiopathology*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008168:Lung / Q000503:physiopathology*; D008297:Male; D009752:Nutritional Status; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy*; D012129:Respiratory Function Tests; D012141:Respiratory Tract Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D055815:Young Adult
D000900:Anti-Bacterial Agents