Resolvin E1 as a novel agent for the treatment of asthma.
BACKGROUND
Asthma is characterized by airway hyperresponsiveness and chronic airway inflammation. Inflammatory cells, including eosinophils and lymphocytes, infiltrate peribronchial tissue in patients with asthma. Resolvin E1 (RvE1) is an anti-inflammatory lipid mediator derived from the omega-3 fatty acid, eicosapentaenoic acid, and has been shown to be involved in resolving inflammation. Although little is known about the actions of RvE1 in the resolution of inflammation due to asthma, recent studies in a mouse model have shown the possibilities of RvE1 in asthma.


OBJECTIVE
We review the current understanding of the mechanism of RvE1 action in connection with asthma pathogenesis and treatment.


CONCLUSIONS
Findings provide evidence for the use of RvE1 as a pivotal counter-regulatory signal in allergic inflammation and offer the possibility of novel multi-pronged therapeutic approaches for human asthma.
Gunma University Graduate School of Medicine, Department of Medicine and Molecular Science, Maebashi, 371-8511 Japan. hisadat@showa.gunma-u.ac.jp
Takeshi
T
Hisada
Tamotsu
T
Ishizuka
Haruka
H
Aoki
Masatomo
M
Mori
D000328:Adult; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000178:diet therapy / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D018957:CD59 Antigens / Q000502:physiology; D002648:Child; D004041:Dietary Fats / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D020024:Leukotriene Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D044045:Lipoxins / Q000502:physiology; D051379:Mice; D018102:Receptors, Leukotriene B4 / Q000037:antagonists & inhibitors*
D018927:Anti-Asthmatic Agents; D018957:CD59 Antigens; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; C513240:LTB4R protein, human; D020024:Leukotriene Antagonists; D044045:Lipoxins; D018102:Receptors, Leukotriene B4; D015118:Eicosapentaenoic Acid; C499823:5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid