Efficient method for the synthesis of pyranoquinoline, thiopyranoquinoline, thienoquinoline, and naphtho[2,7]naphthyridine derivatives catalyzed by iodine.
A mild and efficient method for the synthesis of pyranoquinoline, thiopyranoquinoline, thienoquinoline, and naphtho[2,7]naphthyridine derivatives via three-component reaction of aromatic aldehyde, naphthalen-2-amine, and heterocycloketones, including tetrahydropyran-4-one, tetrahydrothiopyran-4-one, pyridinone, and thiophenone, is described using iodine as catalyst. The features of this procedure are mild reaction conditions, good to high yields, and operational simplicity.
Wang
Xiang-Shan
XS
School of Chemistry and Chemical Engineering, Xuzhou Normal University, The Key Laboratory of Biotechnology on Medical Plant, Xuzhou Jiangsu 221116, PR China. xswang1974@yahoo.com
Li
Qing
Q
Wu
Jian-Rong
JR
Tu
Shu-Jiang
SJ
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D007455:Iodine / Q000737:chemistry*; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
D009287:Naphthyridines; D011714:Pyrans; D011804:Quinolines; D007455:Iodine