IL-17 and Th17 cells in human inflammatory diseases.
IL-17 was discovered in 1995/96 as a T cell derived cytokine with effects on inflammation and neutrophil activation. In 2006, the precise cell source of IL-17 was identified in the mouse, and these cells were named Th17 cells. They play a role in various human diseases associated with inflammation and destruction such as rheumatoid arthritis, psoriasis, Crohn's disease, multiple sclerosis, where IL-17 can be seen as a therapeutic target.
Miossec
Pierre
P
Department of Immunology and Rheumatology, Hôpital Edouard Herriot and Immunogenomics and inflammation research unit EA 4130, University of Lyon; Lyon, France. miossec@univ-lyon1.fr
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology*; D007375:Interleukin-1 / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D007375:Interleukin-1; D020381:Interleukin-17; D014409:Tumor Necrosis Factor-alpha