Antibacterial effect of octylcyanoacrylate against ciprofloxacin-resistant Pseudomonas aeruginosa isolates from patients with chronic suppurative otitis media.
BACKGROUND
There has been a steady increase in the number of cases of ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) otorrhea; this is a growing medical concern. For otological surgery in children, octylcyanoacrylate can be an alternative method of closure for surgical incisions. Recent in vitro studies have shown that octylcyanoacrylate is effective as an antimicrobical barrier. To date, there have been only rare reports on the antibacterial effect of octylcyanoacrylate against CRPA. The purpose of this study is to determine the antimicrobial effects of octyl-cyanoacrylate against the CRPA that was isolated from patients with chronic suppurative otitis media.


METHODS
Clinical CRPA (n=20) bacteria and ciprofloxacin-sensitive PA (CSPA) (n=20) were obtained from patients. The susceptibilities to various antibiotics were determined by disk diffusion method.


RESULTS
Both CSPA and CRPA were resistant to octylcyanoacrylate.


CONCLUSIONS
Results demonstrated that octylcyanoacrylate has no antibacterial activity against CSPA and CRPA.
Department of Otolaryngology, Chonnam National University Medical School, Gwangju, South Korea. chulsavio@hanmail.net
Chul Ho
CH
Jang
Haekyun
H
Park
Yong Bum
YB
Cho
Cheol Hee
CH
Choi
Changhun
C
Song
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000627:therapeutic use; D003487:Cyanoacrylates / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010035:Otitis Media, Suppurative / Q000188:drug therapy / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D003487:Cyanoacrylates; C119247:octylcyanoacrylate; D002939:Ciprofloxacin