From the Sec complex to the membrane insertase YidC.
The key enzymes that catalyze the insertion of proteins into membranes are the Sec translocase and the YidC membrane insertase. Recent insights into the structure and functional intermediates of these enzymes have provided a first molecular glimpse of how they help the newly synthesized proteins to enter the membrane bilayer. In this process, the new proteins undergo a number of specific interactions in the cytoplasm and at the membrane surface before they insert into the bilayer and translocate their external domains across the membrane. The components involved in this pathway recognize each other at the molecular level, forming a route the membrane protein can move along.
Kuhn
Andreas
A
Institute of Microbiology and Molecular Biology, University of Hohenheim, D-70593 Stuttgart, Germany. andikuhn@uni-hohenheim.de
D000251:Adenosine Triphosphatases / Q000502:physiology*; D001426:Bacterial Proteins / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology; D000069816:SEC Translocation Channels; D000081416:SecA Proteins; D018271:Signal Recognition Particle / Q000502:physiology
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D000069816:SEC Translocation Channels; D018271:Signal Recognition Particle; C412443:YIDC protein, E coli; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins