Assessment of bone perfusion with contrast-enhanced magnetic resonance imaging.
Osteoarthritis and avascular necrosis are common clinical entities with unknown origins. Recently, vascular changes were implicated in the pathogenesis of both conditions. This article discusses the use of novel noninvasive imaging techniques as a means of assessing bone perfusion and quantifying differences seen in osteoarthritis and avascular necrosis. Review of our human data suggests that the MRI contrast dye is retained for longer periods of time, suggesting decreased perfusion out of regions of osteoarthritis and avascular necrosis. Use of such a noninvasive measure of assessing bone perfusion could be useful in the diagnosis, prevention, and treatment of not only osteoarthritis and avascular necrosis but also other entities that affect the musculoskeletal system.
Department of Orthopaedic Surgery, Columbia University Medical Center, 622 West 168th Street, PH 1130, New York, NY 10032, USA.
Jonathan H
JH
Lee
Jonathan P
JP
Dyke
Douglas
D
Ballon
Deborah McK
DM
Ciombor
Glenn
G
Tung
Roy K
RK
Aaron
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001855:Bone Marrow Diseases / Q000150:complications / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D004487:Edema / Q000150:complications / Q000175:diagnosis*; D005270:Femur Head / Q000473:pathology; D005500:Follow-Up Studies; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006168:Guinea Pigs; D006801:Humans; D007275:Injections, Intravenous; D007719:Knee Joint / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000150:complications / Q000175:diagnosis*; D020370:Osteoarthritis, Knee / Q000150:complications / Q000175:diagnosis*; D010020:Osteonecrosis / Q000150:complications / Q000175:diagnosis*; D013577:Syndrome; D055815:Young Adult
D003287:Contrast Media; D019786:Gadolinium DTPA