Jurkat cell as an appropriate model for drug investigation.
Increasing of number of various therapeutic agents or medications on the world market require the development of rapid and comparatively cheap methodology for screening of these preparations, elucidation their efficacy and mechanisms of action. In article was investigated the methodology based on modeling of human lymphoblastoid T-cell line Jurkat for the modeling and correction of cell homeostasis disregulation, mitochondria-dependent apoptosis, T-lymphocyte proliferation and differentiation conditions, T-cell activity dependence on the alterations of oxidative metabolism, T cell antigen and effector specificity. This methodology gives rapid and comparatively cheap possibility to provide screening of various medical agents, assessment of their immunomodulatory, pro-and antiapoptogenic efficacy and studying mechanism of action of potentially cardioprotective, antyatherogenic medications increasing efficacy of traditional treatment of cardiovascular diseases.
Tbilisi State Medical University, Tbilisi, Georgia.
L
L
Ratiani
T
T
Sanikidze
M
M
Sulakvelidze
N
N
Bejitashvili
K
K
Meladze
D017209:Apoptosis / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000473:pathology*; D004358:Drug Therapy; D006801:Humans; D019169:Jurkat Cells / Q000187:drug effects* / Q000473:pathology*; D013601:T-Lymphocytes / Q000187:drug effects