The intracellular interactions of the L1 family of cell adhesion molecules.
The L1 family of CAMs (cell adhesion molecules) has long aroused the interest of researchers, but primarily the extracellular interactions of these proteins have been elucidated. More recently, attention has turned to the intracellular signalling potentiated by transmembrane proteins and the cytoplasmic proteins with which they can interact. The present review brings up to date the current body of published knowledge for the intracellular interactions of L1-CAM family proteins and the potential importance of these interactions for the mechanisms of L1-CAM action.
School of Biology, Bute Medical Building, University of St Andrews, St Andrews, Fife, Scotland, U.K. lh30@st-and.ac.uk
Lissa R
LR
Herron
Maria
M
Hill
Fleur
F
Davey
Frank J
FJ
Gunn-Moore
D000818:Animals; D017487:Ankyrins / Q000378:metabolism; D042541:Intracellular Space / Q000378:metabolism*; D039842:Neural Cell Adhesion Molecule L1 / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D025941:Protein Interaction Mapping; D015398:Signal Transduction
D017487:Ankyrins; D039842:Neural Cell Adhesion Molecule L1