[Cellular and molecular deregulations driving the metastatic phenotype].
Cancerogenesis is initiated by DNA instability that induces modifications in stem cells. Regulation is organ specific and depends on morphogenetic factors. DNA instability is alternatively related to chromosomal aberrations or DNA replication errors. Chromosomal instability is the most frequent characteristics of colon adenocarcinoma, and is observed in distant metastatic foci. It is associated with somatic APC mutations that deregulates the WNT pathway. Position of the mutations within the coding sequence are essential for the cell migration capacities thus for stem cell metastasis ability. After this step the new morphogenic program is able induce expansion in the host organ.
Zeitoun
Guy
G
Service de Chirurgie générale et digestive, Centre Hospitalier François Quesnay, 2, boulevard Sully, 78200 Mantes-la-Jolie, France. g.zeitoun@ch-mantes-la-jolie.fr
D043171:Chromosomal Instability; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D017491:Genes, APC; D006801:Humans; D009024:Morphogenesis; D009154:Mutation; D009362:Neoplasm Metastasis / Q000235:genetics*; D010641:Phenotype; D012307:Risk Factors