SCO-ping out the mechanisms underlying the etiology of hydrocephalus.
The heterogeneous nature of congenital hydrocephalus has hampered our understanding of the molecular basis of this common clinical problem. However, disease gene identification and characterization of multiple transgenic mouse models has highlighted the importance of the subcommissural organ (SCO) and the ventricular ependymal (vel) cells. Here, we review how altered development and function of the SCO and vel cells contributes to hydrocephalus.
Huh
Michael S
MS
Regenerative Medicine Program, Ottawa Health Research Institute, Canada.
Todd
Matthew A M
MA
Picketts
David J
DJ
D000818:Animals; D015815:Cell Adhesion Molecules; D002923:Cilia / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid* / Q000209:etiology*; D051379:Mice; D015398:Signal Transduction / Q000502:physiology; D013351:Subcommissural Organ / Q000503:physiopathology*
D015815:Cell Adhesion Molecules