In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
We tested the effect of probenecid and verapamil in chemosensitizing Plasmodium falciparum to 14 antimalarials using the multidrug-resistant strain V1S and the drug-sensitive 3D7. Verapamil chemosensitizes V1S to quinine and chloroquine. Interestingly, probenecid profoundly chemosensitizes V1S to piperaquine. Thus, probenecid could be used to increase piperaquine efficacy in vivo.
Masseno
Victor
V
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program, Kiilfi, Kenya.
Muriithi
Steven
S
Nzila
Alexis
A
D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011339:Probenecid / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology*
D000277:Adjuvants, Pharmaceutic; D000962:Antimalarials; D014700:Verapamil; D011339:Probenecid