Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis.
Wnt/beta-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. Beta-catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both beta-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.
Lai
Shih-Lei
SL
Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
Chien
Andy J
AJ
Moon
Randall T
RT
D002448:Cell Adhesion; D002923:Cilia / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D051157:Frizzled Receptors / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D051157:Frizzled Receptors; D051153:Wnt Proteins; D051176:beta Catenin; D020741:rho GTP-Binding Proteins