Allele distribution and effect on reporter gene expression of vasopressin receptor gene (AVPR1a)-linked VNTR in primates.
We surveyed repeat sequence in the 5' flanking region of primate arginine vasopressin receptor 1a gene (AVPR1a) which is important for social behavior in mammals. The amplified region was polymorphic in length in all species investigated. In addition, length variants were examined for promoter activity by in vitro expression of the luciferase gene. However, no significant difference was observed. This region could be a marker to further survey functional difference between and within species.
Hong
Kyung-Won
KW
The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan.
Matsukawa
Ryota
R
Hirata
Yoko
Y
Hayasaka
Ikuo
I
Murayama
Yuichi
Y
Ito
Shin'ichi
S
Inoue-Murayama
Miho
M
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D001522:Behavior, Animal / Q000502:physiology; D019556:COS Cells; D002522:Chlorocebus aethiops; D019143:Evolution, Molecular; D005786:Gene Expression Regulation / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D017930:Genes, Reporter / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008156:Luciferases; D018598:Minisatellite Repeats / Q000235:genetics*; D008967:Molecular Biology / Q000379:methods; D016716:PC12 Cells; D010802:Phylogeny; D011110:Polymorphism, Genetic / Q000235:genetics; D011323:Primates / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D017483:Receptors, Vasopressin / Q000235:genetics*; D012919:Social Behavior
D005819:Genetic Markers; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; D008156:Luciferases