Apoprotein A-I mimetic peptides and their potential anti-atherogenic mechanisms of action.
OBJECTIVE
Peptides that resemble in physicochemical properties the helices of apoprotein A-I, the major protein of atheroprotective HDL, show promise for the treatment of atherosclerosis-related vascular disease. The properties and promise of these so-called mimetic peptides will be explored in this review.


RESULTS
Both HDL and mimetic peptides are able to scavenge and sequester oxidized lipids and hence protect endothelial cells and arteries from the pro-inflammatory action of oxidized LDL. Active mimetic peptides have an amphipathic alpha-helical secondary structure, whose hydrophobic face is particularly important for its bioactivity. The most frequently employed peptide is 4F. The comparative bioactivity of variants of 4F, particularly tandem helical peptides, has been explored. The recent observation of the very high affinity of bioactive peptides for oxidized fatty acids and phospholipids provides a likely mechanism for the action of these peptides in inhibiting early atherosclerosis formation. It is not clear that these peptides alone are effective in reversing established atherosclerosis, although they may achieve this outcome in synergy with statin therapy.


CONCLUSIONS
Recent observations of mimetic peptides have pointed to promising therapies for patients with cardiovascular disease. The peptides appear to be well tolerated and effective in promoting the anti-inflammatory properties of HDL.
Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA. getz@bsd.uchicago.edu
Godfrey S
GS
Getz
Geoffrey D
GD
Wool
Catherine A
CA
Reardon
D000818:Animals; D016632:Apolipoprotein A-I / Q000737:chemistry*; D050197:Atherosclerosis / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D040761:Biomimetic Materials / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D001808:Blood Vessels / Q000187:drug effects; D006801:Humans; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D017433:Protein Structure, Secondary
D016632:Apolipoprotein A-I; D010455:Peptides