Identification of four urea adducts of andrographolide in humans.
Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liang
L
Cui
Wan
W
Chan
Feng
F
Qiu
Zongwei
Z
Cai
Xinsheng
X
Yao
D000284:Administration, Oral; D000328:Adult; D035685:Andrographis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D004224:Diterpenes / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008516:Medicine, Chinese Traditional; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D014508:Urea / Q000737:chemistry*; D055815:Young Adult
D004224:Diterpenes; C030419:andrographolide; D014508:Urea