The Santa Lucia strain of Plasmodium falciparum in Aotus monkeys.
The Santa Lucia strain of Plasmodium falciparum was studied in 150 Aotus lemurinus griseimembra, 30 A. azarae boliviensis, 103 A. nancymaae, and 121 A. vociferans monkeys. All four of these splenectomized hosts supported the production of gametocytes infective to Anopheles freeborni mosquitoes. Transmission through sporozoites from An. freeborni, An. stephensi, An. maculatus, and An. albimanus mosquitoes was successful to all four species of Aotus on a total of 100 occasions with a median pre-patent period of 21 days. For the production of infective mosquitoes for vaccine challenge studies, A. l. griseimembra and A. vociferans were the most predictable hosts.
National Center for Zoonotic, Vector-Borne, and Enteric Diseases, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. wec1@cdc.gov
William E
WE
Collins
Joann S
JS
Sullivan
Allison
A
Williams
G Gale
GG
Galland
Douglas
D
Nace
Tyrone
T
Williams
John W
JW
Barnwell
D000818:Animals; D000852:Anopheles / Q000145:classification / Q000469:parasitology; D016645:Aotidae / Q000145:classification / Q000469:parasitology*; D002675:Child, Preschool; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007303:Insect Vectors / Q000145:classification / Q000469:parasitology; D016778:Malaria, Falciparum / Q000469:parasitology* / Q000635:transmission; D010963:Plasmodium falciparum / Q000145:classification* / Q000502:physiology; D013156:Splenectomy; D013997:Time Factors