Developmental trajectories of young girls with fragile x syndrome.
To describe the early phenotype of girls with full mutation fragile X, we used 54 observations of 15 girls between the ages of 6 months and 9 years to examine developmental trajectories as measured by the Battelle Development Inventory. In this sample, autistic behavior was associated with poorer developmental outcomes, primarily due to interactions of age with autistic behavior, even though autistic behavior, measured continuously, was relatively mild. Although this small sample, ascertained primarily through male relatives with fragile X syndrome, limits generalizability, considerable variability in developmental outcome in young girls was documented. In addition, findings support previous research suggesting that even mild autistic behaviors in girls can be associated with developmental outcomes.
Hatton
Deborah D
DD
University of North Carolina at Chapel Hill, USA. hatton@mail.fpg.unc.edu
Wheeler
Anne
A
Sideris
John
J
Sullivan
Kelly
K
Reichardt
Alison
A
Roberts
Jane
J
Clark
Renee
R
Bailey
Donald B
DB
D000223:Adaptation, Psychological; D000367:Age Factors; D000704:Analysis of Variance; D001321:Autistic Disorder / Q000209:etiology / Q000523:psychology*; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003071:Cognition; D005260:Female; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics; D005600:Fragile X Syndrome / Q000150:complications / Q000523:psychology*; D006801:Humans; D007223:Infant; D009154:Mutation; D009483:Neuropsychological Tests; D010641:Phenotype; D012919:Social Behavior
D051860:Fragile X Messenger Ribonucleoprotein 1