Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase.
A range of enantiomerically pure (R)- and (S)-configured chiral amines has been prepared in excellent e.e. (99%) by combining a transaminase enzyme with an amino acid oxidase and catalytic quantities of pyruvate.
Truppo
Matthew D
MD
School of Chemistry, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, UKM1 7DN.
Turner
Nicholas J
NJ
Rozzell
J David
JD
D000588:Amines / Q000737:chemistry*; D000594:Amino Acid Oxidoreductases / Q000737:chemistry*; D002384:Catalysis; D007700:Kinetics; D013237:Stereoisomerism; D000637:Transaminases / Q000737:chemistry*
D000588:Amines; D000594:Amino Acid Oxidoreductases; D000637:Transaminases