3D reconstructions of the cerebral ventricles and volume quantification in children with brain malformations.
OBJECTIVE
The aim of this study was to assess the ability of a semiautomated process to produce three-dimensional reconstructions of the ventricles and calculate ventricular volumes from magnetic resonance (MR) imaging data in children with structural brain abnormalities.


METHODS
Fourteen children referred for MR imaging of the brain for neurologic symptoms were selected. Seven participants had structural brain abnormalities on MR imaging; seven further participants were age-matched controls with normal brain morphology. MR imaging included T1-weighted volumetric images in all cases. Semiautomated postprocessing techniques were performed on the MR imaging data to generate three-dimensional reconstructions of the ventricles. These were analyzed for morphologic changes, and volumes were calculated. Inter- and intrarater agreement of ventricular volumes were calculated.


RESULTS
This technique produced detailed three-dimensional reconstructions of the ventricles, even in children with grossly abnormal ventricular morphology. All MR imaging data were successfully postprocessed in <5 minutes. Inter- and intrarater reliability was excellent, with correlation coefficients of 0.99 and 0.92, respectively.


CONCLUSIONS
This methodology can create detailed three-dimensional visualizations and volumetric measurements of morphologically abnormal ventricles. This technique could help physicians and parents comprehend abnormal ventricular anatomy better and may have future clinical uses in monitoring disease progression or neurosurgical planning.
Department of Radiology, German Cancer Research Center, Heidelberg, Germany. frederik@egiesel.com
Frederik L
FL
Giesel
Anthony R
AR
Hart
Horst K
HK
Hahn
Emma
E
Wignall
Fabian
F
Rengier
Roland
R
Talanow
Iain D
ID
Wilkinson
Christian M
CM
Zechmann
Marc-Andrè
MA
Weber
H U
HU
Kauczor
Marco
M
Essig
Paul D
PD
Griffiths
D000293:Adolescent; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology*; D002552:Cerebral Ventricles / Q000002:abnormalities* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009929:Organ Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity