Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation.
A continuous flow tubing reactor can be used to readily transform methyl or ethyl carboxylic esters into the corresponding hydroxamic acids. Flow rate, reactor volume, and temperature were optimized for the preparation of a small collection of hydroxamic acids. Synthetic advantages were identified as an increased reaction rate and higher product purity. This method was also successfully applied to the multistep preparation of suberoylanilide hydroxamic acid, a potent HDAC inhibitor used in anticancer therapy.
Riva
Elena
E
Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, 20133 Milan, Italy.
Gagliardi
Stefania
S
Mazzoni
Caterina
C
Passarella
Daniele
D
Rencurosi
Anna
A
Vigo
Daniele
D
Martinelli
Marisa
M
D004952:Esters / Q000737:chemistry; D006877:Hydroxamic Acids / Q000138:chemical synthesis*; D008872:Microwaves; D000077337:Vorinostat
D004952:Esters; D006877:Hydroxamic Acids; D000077337:Vorinostat