[Stress-protective effect of the KKRR synthetic peptide corresponding to the 15-18 sequence of human adrenocorticotropic hormone].
The activity of the KKRR synthetic peptide corresponding to the 15-18 sequence of human adrenocorticotropic hormone (ACTH) and its analogues KKKK, RRRR, RRKK, kKRR, KkRR, KKrR, and KKRr (amino acid residues of the D configuration are designated by small letters) was studied in vivo on rats under cold and heat shock. Intranasal administration of the KKRR peptide at doses of 2-10 microg/animal 1 day before the shock was found to prevent a dramatic increase in the level of corticosterone in rat adrenal glands and blood plasma caused by the temperature effect. Amino acid substitutions in the KKRR peptide were shown to result in an abrupt decrease in its activity. The peptide analogues exhibit a low stress-protective activity and had a low affinity for the ACTH receptor.
Sadovnikov
V B
VB
Sazhin
A I
AI
Zolotarev
Iu A
IuA
Navolotskaia
E V
EV
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000187:drug effects / Q000502:physiology*
D010446:Peptide Fragments; D010455:Peptides; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone