beta-tting on p63 as a metastatic suppressor.
Although much is known about the genes that promote metastasis, few suppressors of metastasis have been found. Adorno et al. (2009) now identify p63 as a potent suppressor of metastasis and uncover an intricate mechanism for the inactivation of metastasis in cancer cells in response to transforming growth factor beta.
Clohessy
John G
JG
Cancer Genetics Program, Beth Israel Deaconess Cancer Center and Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Pandolfi
Pier Paolo
PP
D000818:Animals; D006801:Humans; D009362:Neoplasm Metastasis; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors; D016212:Transforming Growth Factor beta / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins