Impact of mitochondrial dynamics on organismic aging.
Mitochondria, the cellular powerhouses, are mandatory to keep eukaryotic cells alive. The function of these organelles has to be regulated carefully, as they also have an important impact on the regulation of cell death programs and aging. In the past few years, it became clear that the dynamic morphology changes of mitochondria by division and fusion events play a crucial role in controlling most of these mitochondrial activities. This article examines established and putative mechanisms of how the regulation of mitochondrial dynamics influences various parameters related to aging.
Scheckhuber
Christian Q
CQ
Johann Wolfgang Goethe University, Cluster of Excellence Macromolecular Complexes and Faculty for Biosciences, Molecular Developmental Biology, Max-von-Laue-Str. 9, 60438 Frankfurt/Main, Germany. scheckhuber@bio.uni-frankfurt.de
D000375:Aging / Q000502:physiology*; D000818:Animals; D008928:Mitochondria / Q000502:physiology*; D048468:Podospora / Q000235:genetics / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species