Fingering modulators of retinoic acid signaling identifies new prognostic marker for neuroblastoma.
Properly designed genome-wide screening strategies can provide new insights into biological processes and/or biomarkers for malignant diseases. In this issue of Cancer Cell, Huang et al. demonstrate that the Krüppel zinc-finger protein ZNF423 is critical for retinoic acid signaling and is likely a favorable prognostic marker for neuroblastoma.
Gronemeyer
Hinrich
H
Department of Cancer Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CU de Strasbourg, France. hg@igbmc.fr
Zelent
Arthur
A
D000970:Antineoplastic Agents / Q000494:pharmacology*; D014408:Biomarkers, Tumor; D002454:Cell Differentiation / Q000187:drug effects*; D006801:Humans; D009447:Neuroblastoma / Q000473:pathology*; D011379:Prognosis; D015398:Signal Transduction / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology*; D016335:Zinc Fingers / Q000502:physiology*
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D014212:Tretinoin