Dibromopyrrole alkaloids from the marine sponge Acanthostylotella sp.
Fourteen dibromopyrrole alkaloids were isolated from the marine sponge Acanthostylotella sp. collected in Indonesia. In addition to the known compounds 4,5-dibromo-N-(methoxy-methyl)-1H-pyrrole-2-carboxamide (7), 4,5-dibromo-1H-pyrrole-2-carboxamide (8), mukanadin D (9), (+/-)-longamide B methyl ester (10), (+/-)-longamide B (11), (+/-)-longamide (12), 3,4-dibromo-lH-pyrrole-2-carboxamide (13), 2-cyano-4,5-dibromo-1H-pyrrole (14), six compounds were isolated that proved to be new natural products including acanthamides A-D (1-4), methyl 3,4-dibromo-1H-pyrrole-2-carboxylate (5) and 3,5-dibromo-1H-pyrrole-2-carboxylic acid (6). The structures of the new compounds were unequivocally identified based on one and two dimensional NMR and on HRFTMS as well as by comparison with the literature.
Ebada
Sherif Saeed
SS
Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany.
Edrada-Ebel
RuAngelie
R
de Voogd
Nicole J
NJ
Wray
Victor
V
Proksch
Peter
P
D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
D000470:Alkaloids; D011758:Pyrroles