Hyperbaric oxygen causes both antiinflammation and antipyresis in rabbits.
Current study was attempted to assess whether hyperbaric oxygen pretreatment or treatment exerts its antipyresis by reducing circulating interleukin-6 and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E(2) in rabbits. It was found that systemic administration of lipopolysaccharide induced increased levels of both core temperature and hypothalamic levels of glutamate, hydroxyl radicals, and prostaglandin E(2) accompanied by increased plasma levels of interleukin-6. The rise in both the core temperature and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E(2) could also be induced by intracerebroventricular injection of interleukin-6. Pretreatment or treatment with hyperbaric oxygen significantly reduced the lipopolysaccharide-induced overproduction of circulating interleukin-6, and hypothalamic glutamate, prostaglandin E(2), and hydroxyl radicals. The febrile response caused by central administration of interleukin-6 could also be suppressed by hyperbaric oxygen pretreatment or treatment. Simultaneous administration of an anti-oxidant (e.g., N-acetyl-L-cysteine) significantly enhanced the antipyretic effects exerted by hyperbaric oxygen treatment. These results indicate that hyperbaric oxygen pretreatment or treatment may exert its antipyresis by inhibiting the glutamate-hydroxyl radicals-prostaglandin-E(2) pathways in the hypothalamus and circulating interleukin-6 accumulation during lipopolysaccharide-fever.
Department of Biotechnology, Southern Taiwan University, Tainan, Taiwan.
Ko-Chi
KC
Niu
Wu-Tein
WT
Huang
Mao-Tsun
MT
Lin
Kuo-Fong
KF
Huang
D000111:Acetylcysteine / Q000008:administration & dosage / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D015232:Dinoprostone / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007267:Injections; D015850:Interleukin-6 / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity; D008297:Male; D010100:Oxygen / Q000494:pharmacology*; D011817:Rabbits
D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D008070:Lipopolysaccharides; D017665:Hydroxyl Radical; D018698:Glutamic Acid; D015232:Dinoprostone; D010100:Oxygen; D000111:Acetylcysteine