Activity of pemetrexed against brain metastases in a patient with adenocarcinoma of the lung.
A 53-year-old woman was with adenocarcinoma of the lung metastatic to the brain was treated after several lines of chemotherapy with pemetrexed. After six cycles an impressive regression of the brain metastases was documented. A brief review of the literature on response of cerebral metastases to chemotherapy is added.
Division of Oncology and Hematology, Cantonal Hospital St Gallen, St Gallen, Switzerland. aurelius.omlin@kssg.ch
A
A
Omlin
G
G
D'Addario
S
S
Gillessen
T
T
Cerny
A
A
von Hessling
M
M
Früh
D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology / Q000556:secondary*; D002637:Chest Pain; D018450:Disease Progression; D004417:Dyspnea; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D005971:Glutamates / Q000627:therapeutic use*; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006261:Headache; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009367:Neoplasm Staging; D000068437:Pemetrexed; D011878:Radiotherapy; D012074:Remission Induction; D012907:Smoking; D013903:Thoracic Surgery; D014805:Vitamin B 12 / Q000008:administration & dosage
D000964:Antimetabolites, Antineoplastic; D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D005492:Folic Acid; D014805:Vitamin B 12