Evaluation of polymeric films for buccal drug delivery.
The objective of this study was to evaluate the suitability of the bioadhesive polymers Carbopol 981 NF, Carbopol 1382 and sodium alginate as possible carriers for films for buccal drug delivery. Films were prepared by casting and solvent evaporation method, using propylene glycol as plasticizer and hydoxypropylmethyl cellulose to modify the properties of the films. The bioadhesive and mechanical properties of the films were evaluated with a TA-XT2i Texture Analyser. The alginate films exhibited greater bioadhesion and showed higher tensile strength and elasticity than the Carbopol films. There was a marked difference in the way the polymeric films hydrated in simulated saliva solution. Upon swelling the diameter of the alginate films did not increase but their thickness increases slightly, however the surface area of the Carbopol films increased significantly which points to them being unsuitable for drug delivery to the buccal mucosa. Excessive hydration of a polymeric film for buccal delivery could lead to decreasing adhesive strength and possibly loss of adhesion and hence shorter duration of retention. HPMC appeared to improve the properties of the films, affecting the bioadhesiveness and increasing tensile strength. For the alginate films an increase in HPMC leads to an increase in elasticity but for the Carbopol polymers this was not the case. The release profile of a model drug, sumatriptan succinate, showed that drug release was by diffusion rather than due to disintegration of the films. The results indicate that sodium alginate may be a suitable carrier for polymeric films for use in the buccal cavity.
Faculty of Pharmaceutical Sciences, University of Iceland, Hagi, Hofsvallagata 53, 107 Reykjavik, Iceland. skulis@hi.is
S
S
Skulason
M S
MS
Asgeirsdottir
J P
JP
Magnusson
T
T
Kristmundsdottir
D000180:Acrylic Resins; D000268:Adhesiveness; D000278:Administration, Buccal; D000464:Alginates; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D004548:Elasticity; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives; D011108:Polymers; D011409:Propylene Glycols / Q000737:chemistry; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage; D012995:Solubility; D018170:Sumatriptan / Q000008:administration & dosage; D013718:Tensile Strength
D000180:Acrylic Resins; D000464:Alginates; C516894:Carbopol 981; D006603:Hexuronic Acids; D011108:Polymers; D011409:Propylene Glycols; D017366:Serotonin Receptor Agonists; D065347:Hypromellose Derivatives; D020723:Glucuronic Acid; D018170:Sumatriptan; D008747:Methylcellulose