[Age-specific peculiarities of changes in glutathione system in rat's heart in immobilization stress].
State of glutathione pool and activity of its metabolism enzymes in the hearts of adult and aged rats during immobilization stress were studied in order to find out the causes of age-dependent decrease of heart resistance to stress. The study revealed the absence of difference between state of glutathione pool in myocardium of adult and aged intact rats. Rats of both age groups showed the decrease of reduced glutathione content in the heart during immobilization stress. Adult rats had simultaneous increase of oxidized glutathione concentration in the heart unlike in aged rats. The possibility of age-specific changes of pathways of reduced glutathione utilization' in the heart during stress is discussed.
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Shvets
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Davydov
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008297:Male; D008929:Mitochondria, Heart / Q000201:enzymology / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D050050:Protein Carbonylation; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*
D000975:Antioxidants; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione