Evaluation of ischemia-modified albumin in myocardial infarction and prostatic diseases.
BACKGROUND
Ischemia-modified albumin (IMA) has been shown to be a rapidly rising and sensitive biochemical marker for the diagnosis of myocardial ischemia. In this study, we evaluated the levels of IMA in myocardial infarction and prostate diseases, as well as the influence of HDL cholesterol levels on C-reactive protein (CRP) and IMA levels.


METHODS
A total of 27 patients with myocardial infarction (MI), 102 patients with benign prostatic hyperplasia (BPH), 84 patients with prostate cancer (PCA), and 21 healthy subjects were enrolled in this study. IMA levels were measured in whole studied patients. Cardiac troponin I (cTnI), cholesterol, HDL cholesterol, and CRP were measured in MI and control groups.


RESULTS
IMA values were significantly higher in patients with MI (0.5215+/-0.0241 ABSU) and BPH (0.4150+/-0.0156 ABSU) in comparison to control subjects (0.3381+/-0.0194 ABSU). IMA and CRP were higher in MI group, especially in patients with HDL cholesterol levels lower than 38 mg/dL. The ability of IMA to discriminate myocardial infarction was higher than CRP. Significant correlations between CRP and HDL, CRP and IMA, and HDL and IMA were reported.


CONCLUSIONS
IMA and CRP increase in myocardial damage, and the decrease of HDL cholesterol appears to enhance the inflammatory response. IMA also increase in benign prostate hyperplasia and this finding suggests that the diagnosis of prostate diseases must be considered on evaluation of IMA as a marker of cardiac ischemia.
Mastella
Aline K
AK
Department of Clinical and Toxicological Analysis, Centre of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Moresco
Rafael N
RN
da Silva
Dievan Bisognin
DB
Becker
Aline M
AM
Duarte
Marta M M F
MM
Giovelli
Letícia L
LL
da Silva
Sandra Huber
SH
Rossato
Luana
L
Moretto
Maria B
MB
da Silva
José E Paz
JE
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D007511:Ischemia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology*; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000503:physiopathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000378:metabolism*
D015415:Biomarkers; D008076:Cholesterol, HDL; D012709:Serum Albumin; D002097:C-Reactive Protein