Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction.
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death. Although the underlying pathomechanism remains poorly understood, COPD is accompanied by increased cellular stress and inflammation. We investigated serum contents of heat shock proteins (HSP 27, 60, 70, 90 alpha), 20S proteasomes, C-reactive protein (CRP), and interleukin-6 (IL-6) in patients with mild or severe COPD, healthy smokers and nonsmokers. HSP27, HSP70 and HSP90 alpha were significantly altered in patients suffering from COPD as compared to controls. HSP27 and HSP70 are potential novel serum markers for the diagnosis of COPD in the smoking population. This is the first study to demonstrate elevated serum levels of the described heat shock proteins in patients with COPD. We showed sensitivity and specificity of serum HSP27 and HSP70 as diagnostic markers for COPD.
Department of Surgery, Medical University of Vienna, Austria.
Stefan
S
Hacker
Christopher
C
Lambers
Konrad
K
Hoetzenecker
Andreas
A
Pollreisz
Clemens
C
Aigner
Michael
M
Lichtenauer
Andreas
A
Mangold
Tina
T
Niederpold
Matthias
M
Zimmermann
Shahrokh
S
Taghavi
Walter
W
Klepetko
Hendrik Jan
HJ
Ankersmit
D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D055551:HSP27 Heat-Shock Proteins / Q000097:blood*; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D018841:HSP90 Heat-Shock Proteins / Q000097:blood*; D006360:Heat-Shock Proteins; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D016015:Logistic Models; D018832:Molecular Chaperones; D046988:Proteasome Endopeptidase Complex / Q000097:blood; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012907:Smoking; D018709:Statistics, Nonparametric
D015415:Biomarkers; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; C533585:HSP90AA2P protein, human; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D015850:Interleukin-6; D018832:Molecular Chaperones; D002097:C-Reactive Protein; D046988:Proteasome Endopeptidase Complex