DNA condensation induced by ruthenium(II) polypyridyl complexes [Ru(bpy)(2)(PIPSH)](2+) and [Ru(bpy)(2)(PIPNH)](2+).
Two novel DNA-intercalating ruthenium(II) complexes, [Ru(bpy)(2)(PIPSH)](2+) and [Ru(bpy)(2)(PIPNH)](2+), have been synthesized and characterized. Gel retardation assay, atomic force microscopy, and dynamic light scattering studies show that both complexes can induce the condensation of originally circular plasmid pBR322 DNA to particulate structures under neutral conditions.
Sun
Bin
B
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China.
Guan
Jing-Xin
JX
Xu
Li
L
Yu
Bo-Le
BL
Jiang
Long
L
Kou
Jun-Feng
JF
Wang
Li
L
Ding
Xi-Dong
XD
Chao
Hui
H
Ji
Liang-Nian
LN
D004247:DNA / Q000737:chemistry*; D004587:Electrophoresis, Agar Gel; D008027:Light; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012542:Scattering, Radiation
D009942:Organometallic Compounds; C542258:bis(2,2'-bipyridine)(2-(4-benzoimidazolyl)phenylimidazo(4,5-f)(1,10)phenanthroline)ruthenium(II); C542257:bis(2,2'-bipyridine)(2-(4-benzothiazolyl)phenylimidazo(4,5-f)(1,10)phenanthroline)ruthenium(II); D004247:DNA