Radioactive synthesis and biodistribution study of beta-elemene-99mTc(CO)3 conjugates.
Beta-elemene, (5S,7R,10S)-(-)-(1-methyl-1-vinyl-2,4-diisopropenylcyclohexane), is an anticancer agent from traditional Chinese herbal medicine. Three novel (99m)Tc(CO)(3)-beta-elemene conjugates were synthesized successfully, and compared with beta-elemene exhibited improved water solubility. A biodistribution and micro single photon emission computed tomography image study showed there is a visible accumulation in Lewis lung cancer tumors.
Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Yanhong
Y
Sun
Yunfeng
Y
Ren
Hua
H
Zhu
Yuanqing
Y
Zhang
Guifeng
G
Liu
Chunchun
C
Zhang
Liliang
L
Huang
Jia
J
Xu
Yujin
Y
Qi
Yu-Mei
YM
Shen
D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D000442:Octanols / Q000737:chemistry; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D011851:Radioactivity; D012717:Sesquiterpenes / Q000737:chemistry*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon; D014867:Water / Q000737:chemistry
D000442:Octanols; D015609:Organotechnetium Compounds; D012717:Sesquiterpenes; C445979:beta-elemene; D014867:Water