Osteoclast injection: a promising approach of cell therapy to obtain higher bone union ratio.
Bone nonunion can occur for a number of reasons. Previous studies have tended to focus on the issue as a dysfunction of osteoblasts, as well as a lack of angiogenesis. The functions of osteoclasts are often ignored, even though, in fact, osteoclasts are involved in the whole bone fracture healing and reconstruction process. Inhibition of osteoclastogenesis or dysfunction of osteoclasts can seriously affect the course of fracture healing, increasing the risk of bone nonunion. Therefore, we hypothesized that, by injection of osteoclast at certain bone healing stages, the bone nonunion ratio could be reduced, especially for the sclerosis nonunion that occurs mainly because of the disabling of osteoclastogenesis which leading to the final medullary cavity closure.
The Orthopaedic Department, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
Xuejun
X
Cao
Fang
F
Ren
Peng
P
Zhang
Zhenan
Z
Zhu
D000818:Animals; D017690:Cell Transplantation; D051379:Mice; D010010:Osteoclasts; D010012:Osteogenesis