A simplified green chemistry approaches to synthesis of 2-substituted 1,2,3-triazoles and 4-amino-5-cyanopyrazole derivatives conventional heating versus microwave and ultrasound as ecofriendly energy sources.
Cyanoacetamides 3 were prepared via reacting ethyl cyanoacetate with benzylamine. Yields and reaction times needed for reaction completion at room temperature, by microwaves (muomega) heating and under ultrasound (US) irradiations are compared. The formed cyanoacetamides were coupled with aromatic diazonium salts and the formed arylhydrazones were used as precursors to title triazoles and pyrazoles via reacting the former with hydroxylamine and chloroacetonitrile. Yields of products formed via conventional heating are compared with those of muomega and US irradiation.
Al-Zaydi
Khadijah M
KM
Department of Chemistry, Girls' College of Education, King Abdul-Aziz University, P.O. Box 50918, Jeddah 21533, Kingdom of Saudi Arabia. Alzaydi_kh@yahoo.com
D055772:Green Chemistry Technology / Q000379:methods*; D006358:Hot Temperature; D008872:Microwaves; D009570:Nitriles / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry; D011687:Purines / Q000737:chemistry; D011688:Purinones / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014465:Ultrasonics
D009570:Nitriles; D010879:Piperazines; D011687:Purines; D011688:Purinones; D011720:Pyrazoles; D013450:Sulfones; D014230:Triazoles; D000068677:Sildenafil Citrate; C011145:zaprinast; C031594:2-cyanoacetamide