Tailor-made dissolution profiles by extruded matrices based on lipid polyethylene glycol mixtures.
Extrudates consisting of various ratios of tripalmitin and polyethylene glycol as matrix materials were produced below their melting temperatures. Tailor-made dissolution profiles for the model drug theophylline anhydrate were obtained by varying the matrix composition. The hydrophilic polymer polyethylene glycol increases the dissolution rate of the drug from the extruded matrix by its dissolution and hence formation of an interconnected pore network alleviating the release of the drug. Even though lipid-based dosage forms often suffer from polymorphic transitions during manufacturing, affecting the dissolution profiles and stability, these extrudates were found to exhibit stable solid-state behaviour. No polymorphic transformations were evident after extrusion. Stability testing was performed by open storage experiments over one year in accelerated conditions (40 degrees C/75 %RH). Each formulation remained in its stable conformation.
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, 40225 Düsseldorf, Germany.
Maike
M
Windbergs
Clare J
CJ
Strachan
Peter
P
Kleinebudde
D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D011092:Polyethylene Glycols / Q000737:chemistry*; D033362:Powder Diffraction; D012995:Solubility; D013696:Temperature; D013806:Theophylline / Q000008:administration & dosage* / Q000737:chemistry*; D014280:Triglycerides / Q000737:chemistry*; D014961:X-Ray Diffraction
D004337:Drug Carriers; D014280:Triglycerides; D011092:Polyethylene Glycols; D013806:Theophylline; C005859:tripalmitin