Invertebrate allorecognition: the origins of histocompatibility.
Alloimmune specificity and histocompatibility, driven by genetic polymorphism, are ancient determinants of self-/non-self-recognition. Recent molecular genetic evidence has revealed an allodeterminant in the cnidarian Hydractinia that consistently predicts histocompatibility reactions.
Department of Pediatrics, University of South Florida, 830 First Street South, St. Petersburg, FL 33701, USA.
Larry J
LJ
Dishaw
Gary W
GW
Litman
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D006648:Histocompatibility / Q000235:genetics / Q000276:immunology*; D037402:Hydrozoa / Q000235:genetics / Q000276:immunology*; D008285:Major Histocompatibility Complex; D010641:Phenotype