Balance of Th1 and Th17 effector and peripheral regulatory T cells.
Transfer of antigen-specific T cells into antigen-expressing lymphopenic recipients leads to the sequential generation of Th1 and Th17 effector and protective CD25(+)FoxP3(+) regulatory cells in the periphery with surprisingly different kinetics. Such an experimental model is potentially valuable for defining the stimuli that regulate lineage decision and plasticity of various T cell effectors and peripheral regulatory T cells. Our studies have shown that IL-17 production occurs rapidly and declines within the first week with the appearance of IFN-gamma producing T cells. Regulatory T cells appear during the recovery phase of the disease. The factors that mediate this complex differentiation originating from a starting naïve T cell population remain to be defined.
Department of Pathology, University of California, School of Medicine, San Francisco, CA 94143, USA.
Jens
J
Lohr
Birgit
B
Knoechel
David
D
Caretto
Abul K
AK
Abbas
D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*; D018417:Th1 Cells / Q000166:cytology / Q000276:immunology*
D020381:Interleukin-17