Dual-function probe to detect protease activity for fluorescence measurement and 19F MRI.
Dynamic duo: Magnetic resonance imaging (MRI) can visualize deep regions of living bodies, whereas fluorescence measurement offers excellent sensitivity. These methods thus offer signal enhancement potential for detecting enzyme activities. A dual-mode off/on probe to detect caspase-3 activity by fluorescence and (19)F MRI is presented.
Graduate School of Engineering, Osaka University, Osaka 565-0871, Japan.
Shin
S
Mizukami
Rika
R
Takikawa
Fuminori
F
Sugihara
Masahiro
M
Shirakawa
Kazuya
K
Kikuchi
D053148:Caspase 3 / Q000737:chemistry*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D008163:Luminescent Measurements; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
D005456:Fluorescent Dyes; D009842:Oligopeptides; D009942:Organometallic Compounds; C541171:gadolinum-DOTA-aspartyl-glutamyl-valyl-aspartic acid -7-amino-4-trifluoromethylcoumarin; C526603:gadolinum-DOTA-aspartyl-glutamyl-valyl-aspartic acid 4-trifluoromethoxybenzylamide; D005461:Fluorine; D053148:Caspase 3