Alternative indications for bisphosphonate therapy.
Bisphosphonates are currently used in the treatment of osteoporosis (postmenopausal and steroid-induced), hypercalcemia of malignancy, Paget's disease of bone, multiple myeloma, and skeletally related events associated with metastatic bone disease in breast, prostate, lung, and other cancers. There are, however, numerous other conditions where a decrease in bone remodeling by bisphosphonates might aid in disease management. The focus of this review will be to discuss a select group of conditions for which bisphosphonate therapy may be efficacious. In this review we present several cases where bisphosphonates have been used as a primary or adjunctive treatment for giant cell lesions of the jaws. Use of bisphosphonate therapy for giant cell tumors of the appendicular skeleton, pediatric osteogenesis imperfecta, fibrous dysplasia, Gaucher's disease, and osteomyelitis will be discussed. Finally, we will review previous in vivo studies on the use of bisphosphonates to augment integration and to treat osteolysis surrounding failing orthopedic implants.
Division of Oral and Maxillofacial Surgery, University of Connecticut Health Center, School of Dental Medicine, Farmington, CT 06032, USA. rlandesberg@uchc.edu
Regina
R
Landesberg
Sidney
S
Eisig
Ilene
I
Fennoy
Ethel
E
Siris
D000293:Adolescent; D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000209:etiology; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy; D015921:Dental Implants / Q000009:adverse effects; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000188:drug therapy; D005776:Gaucher Disease / Q000188:drug therapy; D005870:Giant Cell Tumors / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010013:Osteogenesis Imperfecta / Q000188:drug therapy; D010019:Osteomyelitis / Q000188:drug therapy; D055815:Young Adult
D050071:Bone Density Conservation Agents; D015921:Dental Implants; D004164:Diphosphonates