Relationship between age-related serum concentrations of TGF-beta1 and TGF-beta2 and those of osteoprotegerin and leptin in native Chinese women.
BACKGROUND
Transforming growth factor-beta 1 (TGF-beta1), TGF-beta2, osteoprotegerin (OPG), and leptin are important cytokines in the regulation of bone remodeling. We investigated the relationship of TGF-beta1 and TGF-beta2 concentrations with those of OPG and leptin in Chinese females.


METHODS
The serum concentrations of TGF-beta1, TGF-beta2, OPG, and leptin were measured by ELISA in 459 healthy Chinese females aged 25-80 y.


RESULTS
The mean values (+/-SD) of the serum concentrations of TGF-beta1, TGF-beta2, OPG, and leptin in Chinese females were 29.7+/-1.69 microg/l, 13.7+/-3.86 microg/l, 3.81+/-1.96 pmol/l, and 10.5+/-2.01 microg/l, respectively. Further, the serum TGF-beta1 concentrations of postmenopausal women were significantly lower than those of perimenopausal and premenopausal women (24.3+/-1.59 vs 33.4+/-1.69 and 37.6+/-1.64, respectively), while the TGF-beta2 concentrations of postmenopausal women were significantly higher than those of perimenopausal and premenopausal women (14.6+/-3.91 vs 13.5+/-3.93 and 11.7+/-2.68, respectively). The serum TGF-beta1 concentration was found to be significantly negatively correlated with age (r=-0.335, P=0.000) and the TGF-beta2 concentration, to be significantly positively correlated with age (r=0.230, P=0.000). The TGF-beta1 concentration was found to be significantly negatively correlated with both TGF-beta2 (r=-0.261, P=0.000) and OPG (r=-0.313, P=0.000) concentrations; a significantly positive correlation was found between the TGF-beta1 and leptin concentrations (r=0.164, P=0.000) and between TGF-beta2 and OPG concentrations (r=0.432, P=0.000).


CONCLUSIONS
These results provide age-related reference values of TGF-beta1 and TGF-beta2 in Chinese adult women, and reveal the relationships between these cytokines.
Zhang
Na
N
Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, 139 Renmin-Zhong Rd, Hunan 410011, PR China.
Wu
Xi-Yu
XY
Wu
Xian-Ping
XP
Fu
Xiao-Hua
XH
Du
Xiao-Yong
XY
Xie
Hui
H
Peng
Yi-Qun
YQ
Luo
Xiang-Hang
XH
Liao
Er-Yuan
EY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D044466:Asian People; D015992:Body Mass Index; D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008593:Menopause / Q000097:blood / Q000502:physiology; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D053781:Transforming Growth Factor beta2 / Q000097:blood*
D020738:Leptin; D053244:Osteoprotegerin; D053773:Transforming Growth Factor beta1; D053781:Transforming Growth Factor beta2