A new psoralen derivative with enlarged antiproliferative properties.
Following our results with benzopsoralens as potent photochemotherapeutic agents, we report the antiproliferative evaluation of nitrogenated isoster upon and without UVA irradiation. The evaluated pyridazinopsoralen showed a higher photochemotherapeutic activity with respect to the well-known drug, 8-MOP, and a significant cytotoxicity, also in the dark. This result enlarges the interest in this tetracyclic psoralen derivative skeleton in the search of new anticancer agents.
Department of Pharmaceutical Sciences, University of Padova, Italy.
Lisa
L
Dalla Via
Jose Carlos
JC
González-Gómez
Lázaro Guillermo
LG
Pérez-Montoto
Lourdes
L
Santana
Eugenio
E
Uriarte
Sebastiano
S
Marciani Magno
Ornella
O
Gia
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D002460:Cell Line; D005363:Ficusin / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006168:Guinea Pigs; D006367:HeLa Cells; D006801:Humans; D008730:Methoxsalen / Q000633:toxicity; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry*; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D014466:Ultraviolet Rays
D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011724:Pyridazines; C541592:pyridazino(4,3-h)psoralen; D005363:Ficusin; D008730:Methoxsalen