Biomarkers of inflammation in heart failure.
Heart failure (HF) is characterized by the elaboration of a portfolio of pro-inflammatory cytokines and inflammatory mediators that are considered to contribute to disease progression by virtue of the deleterious effects that these molecules exert on the heart and circulation. Recent studies have suggested that these inflammatory mediators may serve as relevant markers of disease severity and HF prognosis. Moreover, there is evidence that changes in the levels of inflammatory biomarkers may prove useful in following the change in patient clinical status following institution of appropriate HF therapy. This review will focus on the emerging role of inflammatory biomarkers, including pro-inflammatory cytokines, C-reactive protein, and erythrocyte sedimentation rate in patients with HF.
Section of Cardiology, 3C-306A, Michael E. DeBakey V.A. Medical Center, Houston, TX, 77030, USA. bbozkurt@bcm.tmc.edu
Biykem
B
Bozkurt
Douglas L
DL
Mann
Anita
A
Deswal
D015415:Biomarkers; D001799:Blood Sedimentation; D002097:C-Reactive Protein; D018925:Chemokines; D016207:Cytokines; D018450:Disease Progression; D006333:Heart Failure / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D015850:Interleukin-6; D011379:Prognosis; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha
D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein