Geographic variation in the prevalence of Kaposi sarcoma-associated herpesvirus and risk factors for transmission.
BACKGROUND
The aim of the present study was to estimate the prevalence of Kaposi sarcoma-associated herpesvirus (KSHV) in the female general population, to define geographic variation in and heterosexual transmission of the virus.


METHODS
The study included 10,963 women from 9 countries for whom information on sociodemographic characteristics and reproductive, sexual, and smoking behaviors were available. Antibodies against KSHV that encoded lytic antigen K8.1 and latent antigen ORF73 were determined.


RESULTS
The range of prevalence of KSHV (defined as detection of any antigen) was 3.81%-46.02%, with significant geographic variation noted. In Nigeria, the prevalence was 46.02%; in Colombia, 13.32%; in Costa Rica, 9.81%; in Argentina, 6.40%; in Ho Chi Minh City, Vietnam, 15.50%; in Hanoi, Vietnam, 11.26%; in Songkla, Thailand, 10%; in Lampang, Thailand, 8.63%; in Korea, 4.93%; and in Spain, 3.65%. The prevalence of KSHV slightly increased with increasing age among subjects in geographic areas where the prevalence of KSHV was high, such as Nigeria and Colombia, and it significantly decreased with increases in the educational level attained by subjects in those areas. KSHV was not statistically associated with age at first sexual intercourse, number of sex partners, number of children, patterns of oral contraceptive use, presence of cervical human papillomavirus DNA, or smoking status.


CONCLUSIONS
The study provides comparable estimates of KSHV prevalence in diverse cultural settings across 4 continents and provides evidence that sexual transmission of KSHV is not a major source of infection in the general population.
de Sanjose
Silvia
S
Institut Català d'Oncologia, and 2Centro de Investigación Biomédica en Red de Epidemiologia y Salud Pública, Barcelona, Spain. s.sanjose@iconcologia.net
Mbisa
Georgina
G
Perez-Alvarez
Susana
S
Benavente
Yolanda
Y
Sukvirach
Sukhon
S
Hieu
Nguyen Trong
NT
Shin
Hai-Rim
HR
Anh
Pham Thi Hoang
PT
Thomas
Jaiyeola
J
Lazcano
Eduardo
E
Matos
Elena
E
Herrero
Rolando
R
Muñoz
Nubia
N
Molano
Monica
M
Franceschi
Silvia
S
Whitby
Denise
D
D000328:Adult; D000956:Antigens, Viral / Q000235:genetics; D003105:Colombia / Q000453:epidemiology; D003431:Cross-Cultural Comparison; D005260:Female; D006023:Glycoproteins / Q000235:genetics* / Q000302:isolation & purification; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000235:genetics / Q000635:transmission; D019288:Herpesvirus 8, Human; D006801:Humans; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000235:genetics*; D012725:Sexual Behavior; D013785:Thailand / Q000453:epidemiology; D014764:Viral Proteins / Q000235:genetics* / Q000302:isolation & purification
D000956:Antigens, Viral; D006023:Glycoproteins; C113454:K8.1 protein, Human herpesvirus 8; D014764:Viral Proteins