Cushing syndrome as a presenting symptom of renal tumors in children.
Cushing syndrome as the presenting symptom of a malignant renal tumor in children is rare. We report the first case of paraneoplastic Cushing syndrome due to a Wilms tumor, in which clinical and biological signs of hypercortisolism regressed during preoperative chemotherapy. Additionally, we reviewed the literature on paraneoplastic Cushing syndrome secondary to pediatric renal tumors.
Segers
H
H
Department of Pediatric Oncology/Hematology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
van der Heyden
J C
JC
van den Akker
E L T
EL
de Krijger
R R
RR
Zwaan
C M
CM
van den Heuvel-Eibrink
M M
MM
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007680:Kidney Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D009392:Nephrectomy; D010257:Paraneoplastic Syndromes / Q000209:etiology; D011878:Radiotherapy; D009396:Wilms Tumor / Q000150:complications* / Q000473:pathology / Q000628:therapy
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone