Association between circulating soluble receptor for advanced glycation end products and atherosclerosis: observations from the Dallas Heart Study.
OBJECTIVE
To determine the association between circulating soluble receptor for advanced glycation end products (sRAGE) and coronary atherosclerosis.


METHODS
Using data from the Dallas Heart Study, a probability-based population sample, the association between plasma levels of sRAGE and coronary artery calcium (CAC) was assessed among 2,571 subjects with complete imaging and sRAGE data.


RESULTS
An inverse graded association was observed between sRAGE quartiles and CAC, with CAC prevalence of 28.5% in quartile 1 compared with 15.7% in quartile 4 (P < 0.0001). After multivariable adjustment, the associations between sRAGE levels in the first and second quartiles (versus fourth quartile) and CAC remained statistically significant (adjusted odds ratio 1.71 [95% CI 1.2-2.4] and 1.5 [1.0-2.1], respectively).


CONCLUSIONS
sRAGE is a novel biomarker that is inversely associated with coronary atherosclerosis. The role of sRAGE in the pathobiology of atherosclerosis and its potential prognostic and therapeutic implications warrant further investigation.
Lindsey
Jason B
JB
Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
de Lemos
James A
JA
Cipollone
Francesco
F
Ayers
Colby R
CR
Rohatgi
Anand
A
Morrow
David A
DA
Khera
Amit
A
McGuire
Darren K
DK
D000328:Adult; D050197:Atherosclerosis / Q000097:blood*; D002118:Calcium / Q000097:blood; D003331:Coronary Vessels / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D044469:Racial Groups; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D013781:Texas
D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D002118:Calcium