Efficient and convenient preparation of 3-aryl-2,2-dimethylpropanoates via Negishi coupling.
An efficient and convenient Negishi coupling protocol was developed for the preparation of 3-aryl-2,2-dimethylpropanoates providing easy access to key pharmaceutical intermediates that often require multi-step synthesis using conventional enolate chemistry.
Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 100 Technology Sq., Cambridge, MA 02139, USA. youngshin.kwak@novartis.com
Young-Shin
YS
Kwak
Aaron D
AD
Kanter
Bing
B
Wang
Yugang
Y
Liu
D002853:Chromatography, Liquid; D013058:Mass Spectrometry; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry
D011422:Propionates; C029658:propionic acid