First Irish birth following IVF therapy using antagonist protocol.
BACKGROUND
During in vitro fertilization (IVF), the prevention of a premature LH surge was traditionally achieved using a gonadotrophin releasing hormone agonist (GnRH-a), and more recently, a GnRH antagonist.


OBJECTIVE
We report a case of a 37 year old treated using the GnRH antagonist in a second completed cycle of IVF.


METHODS
IVF was performed for primary infertility of 5-year duration due to frozen pelvis secondary to endometriosis.


RESULTS
Following controlled ovarian hyperstimulation, oocyte recovery and fertilization, cleavage and transfer of two zygotes, a pregnancy established. A twin gestation was diagnosed at 7-weeks scan and pregnancy ended with the delivery of twin girls by emergency caesarean section.


CONCLUSIONS
This is a first report of a delivery following IVF using the antagonist protocol in Ireland. Such therapy is patient friendly and its use should be introduced on a larger scale in clinical practice.
Mocanu
E V
EV
HARI Unit, Rotunda Hospital, Dublin 1, Ireland. emocanu@rcsi.ie
Kondaveeti
N
N
Kelly
J
J
Hennelly
B
B
Burke
L
L
Hughes
C
C
D000328:Adult; D002585:Cesarean Section; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D043373:Follicle Stimulating Hormone, Human / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D006801:Humans; D007494:Ireland; D050498:Live Birth; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D014427:Twins; D017388:Zygote Intrafallopian Transfer
D043373:Follicle Stimulating Hormone, Human; D007987:Gonadotropin-Releasing Hormone; C061018:ganirelix