[Histopathological changes in human placentas related to hypertensive disorders].
OBJECTIVE
to determine the prevalence of histopathological changes, in human placentas, related to hypertensive syndromes.


METHODS
a transversal study that compares histopathological changes identified in 43 placentae from hypertensive pregnant women (HypPr), with the ones from 33 placentae from normotensive pregnant women (NorPr). The weight, volume and macroscopic and microscopic occurrence of infarctions, clots, hematomas, atherosis (partial obliteration, thickness of layers and presence of blood vessels hyalinization) and Tenney-Parker changes (absent, discreet and prominent), as well as the locating of infarctions and clots (central, peripheral or the association of both) have been analyzed. The chi2 and t Student tests have been used for the statistical analysis, as well as medians, standard deviations and ratios. It has been considered as significant, p<0.05.


RESULTS
the macroscopic study of HypPr placentae have presented lower weight (461.1 versus 572.1 g) and volume (437.4 versus 542.0 cm(3)), higher infarction (51.2 versus 45.5%; p<0.05: OR=1.15) and clots (51.2 versus 15.1%; p<0.05; OR=5.4) ratios, as compared to the NorPr's. In the HypPr and NorPr, microscopic clots have occurred in 83.7 versus 45.5% (p<0.05; OR=4.3), respectively. Atherosis and Tenney-Parker changes have been statistically associated to the hypertensive syndromes (p<0.05).


CONCLUSIONS
the obtained data allow us to associate lower placentary weight and volume, higher ratio of macro and microscopic infarction, clots, atherosis and Tenney-Parker changes to placentae of gestations occurring with hypertensive syndromes.
Artico
Luciano Guimarães
LG
Ambulatório Central, Universidade de Caxias do Sul, Caxias do Sul, RS, Brasil. casalartico@gmail.com
Madi
José Mauro
JM
Godoy
Alessandra Eifler Guerra
AE
Coelho
Celso Piccoli
CP
Rombaldi
Renato Luís
RL
Artico
Graziela Rech
GR
D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D007238:Infarction / Q000473:pathology; D009929:Organ Size; D010920:Placenta / Q000098:blood supply / Q000473:pathology*; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000473:pathology*; D013927:Thrombosis / Q000473:pathology