Covariates of amikacin clearance in neonates: the impact of postnatal age on predictability.
An earlier reported population pharmacokinetic study documented limited predictability of amikacin clearance (65%) at birth. An exercise in the first month of life resulted in extended predictability (92%) with similar clearance estimates after the first postnatal days, reflecting the impact of postnatal age on clearance predictability.
Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium. karel.allegaert@uz.kuleuven.ac.be
Karel
K
Allegaert
Isabelle
I
Scheers
Veerle
V
Cossey
Brian J
BJ
Anderson
D000367:Age Factors; D000583:Amikacin / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D016208:Databases, Factual; D005544:Forecasting; D006801:Humans; D007231:Infant, Newborn; D008954:Models, Biological
D000900:Anti-Bacterial Agents; D000583:Amikacin