Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia.
It has been long appreciated that anesthetic drugs induce stereotyped changes in electroencephalogram (EEG), but the relationships between the EEG and underlying brain function remain poorly understood. Functional imaging methods including positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), have become important tools for studying how anesthetic drugs act in the human brain to induce the state of general anesthesia. To date, no investigation has combined functional MRI with EEG to study general anesthesia. We report here a paradigm for conducting combined fMRI and EEG studies of human subjects under general anesthesia. We discuss the several technical and safety problems that must be solved to undertake this type of multimodal functional imaging and show combined recordings from a human subject. Combined fMRI and EEG exploits simultaneously the high spatial resolution of fMRI and the high temporal resolution of EEG. In addition, combined fMRI and EEG offers a direct way to relate established EEG patterns induced by general anesthesia to changes in neural activity in specific brain regions as measured by changes in fMRI blood oxygen level dependent (BOLD) signals.
Purdon
Patrick L
PL
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. patrickp@nmr.mgh.harvard.edu
Pierce
Eric T
ET
Bonmassar
Giorgio
G
Walsh
John
J
Harrell
P Grace
PG
Kwo
Jean
J
Deschler
Daniel
D
Barlow
Margaret
M
Merhar
Rebecca C
RC
Lamus
Camilo
C
Mullaly
Catherine M
CM
Sullivan
Mary
M
Maginnis
Sharon
S
Skoniecki
Debra
D
Higgins
Helen-Anne
HA
Brown
Emery N
EN
D000161:Acoustic Stimulation; D000768:Anesthesia, General / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood; D001921:Brain / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood; D014139:Tracheostomy
D018686:Anesthetics, Intravenous; D002245:Carbon Dioxide; D015742:Propofol