The impact of noncoding RNA on the biochemical and molecular mechanisms of aging.
As the molecular mechanisms associated with aging become more understood, it is apparent that the normal processes involved in the development and metabolism of an organism are subject to changes that upset its crucial homeostatic balance, which in turn sets in motion the weakening and disease-prone process of senescence. This imbalance is the result of a variety of effectors, such as environmental insults, endogenous toxins, and genetic mishaps. In addition, it is highly probable that posttranscriptional regulatory events play a large role in the changes associated with aging. The emerging knowledge of posttranscriptional regulation is redefining our understanding of the complexities of cellular systems biology and genetics. The implications of the impact that small regulatory RNAs have on the many facets of developmental and molecular biology should be included as part of our current understanding of the biochemistry involved in these processes. These molecular regulators-along with other epigenetic events-restrict the flow of genetic expression, thus affording the cell an adjustable and tempered homeostatic balance control. Recent findings in the fields of organismal development, cancer, and aging indicate that small noncoding RNA plays a greater role than previously believed in orchestrating the changes associated with these processes. Furthermore, any misappropriations of these regulatory resources could lead to age-related diseases, and are therefore promising targets for prophylactics and therapeutics to combat maladies associated with aging. Here we report a brief overview of noncoding RNA as well as the potential roles of microRNAs in biochemical equilibriums where imbalance contributes to the many phenotypes of aging.
Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
David J
DJ
Bates
Ruqiang
R
Liang
Na
N
Li
Eugenia
E
Wang
D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D035683:MicroRNAs; D022661:RNA, Untranslated; D017382:Reactive Oxygen Species