Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene.
Apigenin, a dietary plant-flavonoid has shown anti-inflammatory and anticancer properties, however the molecular basis of this effect remains to be elucidated. Thus we elucidated to anti-allergic effect of apigenin in ovalbumin (OVA)-induced asthma model mice. The OVA-induced mice showed allergic airway reactions. It included an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid, an increase in inflammatory cell infiltration into the lung around blood vessels and airways, airway luminal narrowing, and the development of airway hyper-responsiveness (AHR). The administration of apigenin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that apigenin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of apigenin in terms of its effects in a murine model of asthma.
Department of Microbiology and Immunology, Pusan National University School of Medicine, Busan 602-739, South Korea.
Jun-Rim
JR
Choi
Chang-Min
CM
Lee
In Duk
ID
Jung
Jun Sik
JS
Lee
Young-Il
YI
Jeong
Jeong Hyun
JH
Chang
Hee-Ju
HJ
Park
Il-Whan
IW
Choi
Jong-Suk
JS
Kim
Yong Kyoo
YK
Shin
Sung Nam
SN
Park
Yeong-Min
YM
Park
D000402:Airway Obstruction; D000818:Animals; D047310:Apigenin / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D001992:Bronchoalveolar Lavage Fluid; D002465:Cell Movement / Q000187:drug effects / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D047209:Eosinophil Peroxidase / Q000378:metabolism; D004802:Eosinophilia; D004804:Eosinophils / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D005260:Female; D050990:GATA3 Transcription Factor / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D007114:Immunization; D007073:Immunoglobulin E / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology
D016207:Cytokines; D050990:GATA3 Transcription Factor; C494748:Gata3 protein, mouse; D007073:Immunoglobulin E; D047310:Apigenin; D010047:Ovalbumin; D047209:Eosinophil Peroxidase; D020780:Matrix Metalloproteinase 9