Prevalence of sleep-disordered breathing in a 316-patient French cohort of stable congestive heart failure.
BACKGROUND
Heart failure with systolic dysfunction occurs frequently. Studies in North America and Germany have shown a high prevalence of sleep-disordered breathing in patients with heart failure.


OBJECTIVE
To assess the prevalence of sleep-disordered breathing and its associated risk factors in French patients with heart failure.


METHODS
A total of 316patients with stable heart failure and a left ventricular ejection fraction less or equal to 45% underwent polygraphy prospectively to diagnose sleep apnoea syndrome, defined as an apnoea-hypopnoea index greater or equal to 10events/h.


RESULTS
Mean age, left ventricular ejection fraction, and body mass index were 59+/-13years, 30+/-11% and 28+/-6kg/m(2), respectively. The prevalence of sleep breathing disorder was 81% (n=256); 30% of syndromes were classified as central and 70% as obstructive. The mean apnoea-hypopnoea index was high (30+/-3events/h) and a large proportion (41%) of syndromes had an apnoea-hypopnoea index greater or equal to 30events/h. A central sleep apnoea syndrome pattern was associated with more severe heart failure and a more elevated apnoea-hypopnoea index than an obstructive pattern. The prevalence of sleep-disordered breathing was lower in women than in men (64% versus 85%; chi(2)=0.0003) as was its severity (mean apnoea-hypopnoea index 15+/-13events/h versus 27+/-19events/h, p=0.0001).


CONCLUSIONS
The prevalence of sleep-disordered breathing was high in a French heart failure population, with most syndromes having an obstructive pattern. Prevalence and severity were higher in men than in women.
Fédération de cardiologie, hôpital Henri-Mondor, groupe hospitalier Henri-Mondor Albert-Chenevier, AP-HP, 51, avenue Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
Alexandra
A
Paulino
Thibaud
T
Damy
Laurent
L
Margarit
Maria
M
Stoïca
Guillaume
G
Deswarte
Latifa
L
Khouri
Emmanuelle
E
Vermes
Anouk
A
Meizels
Luc
L
Hittinger
Marie-Pia
MP
d'Ortho
D000368:Aged; D005260:Female; D005602:France / Q000453:epidemiology; D006333:Heart Failure / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D015995:Prevalence; D011446:Prospective Studies; D012720:Severity of Illness Index; D012737:Sex Factors; D020182:Sleep Apnea, Central / Q000453:epidemiology* / Q000503:physiopathology; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology* / Q000503:physiopathology; D013318:Stroke Volume; D016277:Ventricular Function, Left