Inflammatory bowel disease: a model of chronic inflammation-induced cancer.
Chronic inflammation is a well-recognized risk factor for the development of human cancer. Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a typical longstanding inflammatory disease of the colon with increased risk for the development of colorectal carcinoma. Several molecular events involved in chronic inflammatory process may contribute to multistage progression of human cancer development, including the overproduction of reactive oxygen and nitrogen species, overproduction/activation of key arachidonic acid metabolites and cytokines/growth factors, and immunity system dysfunction. Multiple animal models of IBD have been established, and in general, these models can be mainly categorized into chemically induced, genetically engineered (transgenic or gene knock-out), spontaneous, and adoptive transferring animal models. This chapter mainly focuses on (1) epidemiologic and molecular evidence on IBD and risk of colorectal cancer, (2) molecular pathogenesis of IBD-induced carcinogenesis, and (3) modeling of IBD-induced carcinogenesis in rodents and its application.
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Guang-Yu
GY
Yang
Sofia
S
Taboada
Jie
J
Liao
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D015179:Colorectal Neoplasms / Q000209:etiology / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D007294:Inositol / Q000378:metabolism; D007422:Intestines / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D018384:Oxidative Stress; D012307:Risk Factors
D000970:Antineoplastic Agents; D000975:Antioxidants; D007294:Inositol