The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research.
Survival for childhood cancer has increased dramatically over the last 40 years with 5-year survival rates now approaching 80%. For many diagnostic groups, rapid increases in survival began in the 1970s with the broader introduction of multimodality approaches, often including combination chemotherapy with or without radiation therapy. With this increase in rates of survivorship has come the recognition that survivors are at risk for adverse health and quality-of-life outcomes, with risk being influenced by host-, disease-, and treatment-related factors. In 1994, the US National Cancer Institute funded the Childhood Cancer Survivor Study, a multi-institutional research initiative designed to establish a large and extensively characterized cohort of more than 14,000 5-year survivors of childhood and adolescent cancer diagnosed between 1970 and 1986. This ongoing study, which reflects the single most comprehensive body of information ever assembled on childhood and adolescent cancer survivors, provides a dynamic framework and resource to investigate current and future questions about childhood cancer survivors.
Robison
Leslie L
LL
Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA. les.robison@stjude.org
Armstrong
Gregory T
GT
Boice
John D
JD
Chow
Eric J
EJ
Davies
Stella M
SM
Donaldson
Sarah S
SS
Green
Daniel M
DM
Hammond
Sue
S
Meadows
Anna T
AT
Mertens
Ann C
AC
Mulvihill
John J
JJ
Nathan
Paul C
PC
Neglia
Joseph P
JP
Packer
Roger J
RJ
Rajaraman
Preetha
P
Sklar
Charles A
CA
Stovall
Marilyn
M
Strong
Louise C
LC
Yasui
Yutaka
Y
Zeltzer
Lonnie K
LK
D000293:Adolescent; D000367:Age Factors; D002648:Child; D015331:Cohort Studies; D003710:Demography; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006297:Health Services Accessibility; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D054547:National Cancer Institute (U.S.) / Q000191:economics; D009369:Neoplasms / Q000401:mortality* / Q000628:therapy*; D011159:Population Surveillance; D011788:Quality of Life; D012107:Research Design; D040841:Resource Allocation / Q000706:statistics & numerical data / Q000639:trends; D015996:Survival Rate; D017741:Survivors / Q000706:statistics & numerical data*; D014015:Tissue Banks; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology