Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E(-/-) mice.
The objective of this study was to explicate the effects of feeding low trans structured fat from flaxseed oil (LF) on plasma and hepatic lipid metabolism involved in apo E(-/-) mice. The animals were fed a commercial shortening (CS), commercial low trans fat (CL) and LF diet based on AIN-76 diet (10% fat) for 12 weeks. LF supplementation exerted a significant suppression in hepatic lipid accumulation with the concomitant decrease in liver weight. The LF significantly lowered plasma total cholesterol and free fatty acid whereas it significantly increased HDL-C concentration and the HDL-C/total-C ratio compared to the CS group. Reduction of hepatic lipid levels in the LF group was related with the suppression of hepatic enzyme activities for fatty acid and triglyceride synthesis, and cholesterol regulating enzyme activity compared to the CS and CL groups. Accordingly, low trans structured fat from flaxseed oil is highly effective for improving hyperlipidemia and hepatic lipid accumulation in apo E(-/-) mice.
Cho
Yun-Young
YY
Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
Kwon
Eun-Young
EY
Kim
Hye-Jin
HJ
Park
Yong-Bok
YB
Lee
Ki-Teak
KT
Park
Taesun
T
Choi
Myung-Sook
MS
D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics* / Q000502:physiology; D004435:Eating / Q000187:drug effects; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008043:Linseed Oil / Q000737:chemistry / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009929:Organ Size / Q000187:drug effects; D002785:Sterol O-Acyltransferase / Q000378:metabolism; D044242:Trans Fatty Acids / Q000737:chemistry / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects
D001057:Apolipoproteins E; D044242:Trans Fatty Acids; D008043:Linseed Oil; D006903:Hydroxymethylglutaryl CoA Reductases; D002785:Sterol O-Acyltransferase