Photinides A-F, cytotoxic benzofuranone-derived gamma-lactones from the plant endophytic fungus Pestalotiopsis photiniae.
Photinides A-F (1-6), six new unique benzofuranone-derived gamma-lactones, have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis photiniae. The structures of these compounds were elucidated primarily by NMR spectroscopy, and their absolute configurations were assigned by application of the CD excitation chirality method. Compounds 1-6 displayed modest cytotoxic effects against the human tumor cell line MDA-MB-231.
Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
Gang
G
Ding
Zhihui
Z
Zheng
Shuchun
S
Liu
Hua
H
Zhang
Liangdong
L
Guo
Yongsheng
Y
Che
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010944:Plants / Q000382:microbiology; D013237:Stereoisomerism; D013098:Xylariales / Q000737:chemistry*
D000970:Antineoplastic Agents; D001572:Benzofurans; D007783:Lactones