Vitamin D supplementation does not affect serum lipids and lipoproteins in Pakistani immigrants.
Potential long-term negative effects of increased vitamin D consumption are not thoroughly examined. The aim of this study was to investigate possible negative effects of vitamin D supplementation on serum lipids and lipoproteins. A 1-year long randomised double-blinded placebo-controlled intervention study with two doses of vitamin D3 (10 and 20 microg/day) was carried out among 89 women (18-53 years of age) and 84 men (18-64 years of age) of Pakistani origin living in Denmark with low vitamin D status. This study did not find changes in total cholesterol, LDL-cholesterol, HDL-cholesterol, LDL-cholesterol/HDL-cholesterol ratio, VLDL-cholesterol and triacylglycerol after daily supplementation with 10 or 20 microg vitamin D for 1 year. In conclusion, increasing the vitamin D intake by 10-20 microg per day for 1 year is safe for Pakistani immigrants with regards to serum lipids and lipoproteins.
Department of Nutrition, National Food Institute, Technical University of Denmark, Søborg, Denmark. rian@food.dtu.dk
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D000293:Adolescent; D000328:Adult; D002784:Cholesterol / Q000097:blood*; D003718:Denmark; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000208:ethnology; D014280:Triglycerides / Q000097:blood*; D014807:Vitamin D / Q000008:administration & dosage / Q000009:adverse effects*; D055815:Young Adult
D014280:Triglycerides; D014807:Vitamin D; D002784:Cholesterol