A new twist on brown fat metabolism.
The transcriptional coactivator PGC-1alpha promotes mitochondrial biogenesis and thermogenic programs in brown adipose tissue. Pan et al. (2009) identify the transcription factor twist-1 as a negative feedback regulator of PGC-1alpha.
Wallberg-Henriksson
Harriet
H
Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institutet, S-171 77 Stockholm, Sweden.
Zierath
Juleen R
JR
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D051879:Twist-Related Protein 1 / Q000378:metabolism*
D047495:PPAR gamma; D015534:Trans-Activators; D051879:Twist-Related Protein 1