[Blood transfusion assessment to 112 homozygous sickle-cell disease patients in university hospital of Brazzaville].
Homozygous, sickle-cell disease (SCD) is responsible for acute complication, especially anaemic crisis and special situation such as acute chest syndrome, stroke and acute priapism. Pregnancy sickle-cell disease presents high risk for the mother and the fetus. In these indications, blood transfusion is the main therapy aiming to reduce anaemia in order to restore hemoglobin's rate or to increase normal Hb proportion. This study aims to assess the short-term efficiency of the red cell transfusion in SCD homozygous form. One hundred and twelve homozygous sickle-cell patients were enrolled in this prospective study: 59 females and 53 males, median age is 21,8 years (extremes: 2 and 45 years). These patients are mostly with very low income. Two groups of patients are included in this study. In the first group, patients present acute anemia crisis caused by infections disease (malaria, bacterial infections). In the second group (20 cases), SCD patients have particularly situations: pregnancy (10 cases); stroke (six cases); cardiac failure (two cases) and priapism (two cases). Transfusion treatment in first group is simple regimen. Transfusion of EC increased median Hb level at 2,9 g/dl (extremes: 1,1 and 4,7). In the second group of patients, 16 cases were transfused by manual partial exchange (1-3) and four patients received simple regimen of transfusion. Median Hb level was 3,1g/dl (extremes: 2,4-4,9 g/dl). HbS percentage reduction was after PTE between -30 and -66,8% (median: -52,6%). According to our diagnostic possibilities (blood serologic test), we have not found any contamination by HIV, HBV and HCV (virus).
Service d'hématologie, Centre national de transfusion sanguine, CHU de Brazzaville, avenue Général-de-Gaulle, BP 13027, RC, Brazzaville, Congo. dokekias@yahoo.fr
A Elira
AE
Dokekias
L Ngolet
LN
Ossini
F O Atipo
FO
Tsiba
F
F
Malanda
I
I
Koko
M
M
De Montalembert
D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000209:etiology; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications / Q000628:therapy*; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D017707:Erythrocyte Transfusion; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006720:Homozygote; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy
D006454:Hemoglobins