Keloid scarring: bench and bedside.
Wound healing is a fundamental complex-tissue reaction leading to skin reconstitution and thereby ensuring survival. While, fetal wounds heal without scarring, a normal "fine line" scar is the clinical outcome of an undisturbed wound healing in adults. Alterations in the orchestrated wound healing process result in hypertrophic or keloid scarring. Research in the past decades attempted to identify genetic, cellular, and molecular factors responsible for these alterations. These attempts lead to several new developments in treatments for keloids, such as, imiquimod, inhibition of transforming growth factor beta, and recombinant interleukin-10. The urgent need for better therapeutics is underlined by recent data substantiating an impaired quality of life in keloid and hypertrophic scar patients. Despite the increasing knowledge about the molecular regulation of scar formation no unifying theory explaining keloid development has been put forward until today. This review aims to give an overview about the genetic and molecular background of keloids and focus of the current research on keloid scarring with special emphasis on new forthcoming treatments. Clinical aspects and the spectrum of scarring are summarized.
Seifert
Oliver
O
Department of Dermatology, County Hospital Ryhov, Jonkoping 55185, Sweden. oliver.seifert@lj.se
Mrowietz
Ulrich
U
D000328:Adult; D000634:Aminoquinolines / Q000627:therapeutic use; D002921:Cicatrix / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D000077271:Imiquimod; D007111:Immunity, Cellular; D016753:Interleukin-10 / Q000378:metabolism; D007627:Keloid / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011788:Quality of Life; D015398:Signal Transduction; D051785:Smad Proteins / Q000235:genetics / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*
D000634:Aminoquinolines; D051785:Smad Proteins; D016212:Transforming Growth Factor beta; D016753:Interleukin-10; D000077271:Imiquimod