Booster vaccination of toddlers with reduced antigen content diphtheria -- tetanus -- acellular pertussis vaccine.
Immunogenicity and reactogenicity of DTPa and reduced antigen dTpa booster vaccines were compared to a hepatitis A control vaccine in DTPa-primed toddlers aged 18 - 20 months. Post-booster, all DTPa and dTpa recipients were seroprotected against diphtheria and tetanus, and > or = 93.3% had a booster response to pertussis. There were similar reactogenicity rates in the DTPa and dTpa vaccine recipients. Few Grade 3 symptoms were reported. Just over one in four children in the control group had diphtheria antibody at or potentially below the correlate of protection benchmark (0.016IU/ml). Larger studies should evaluate potential benefits of reduced antigen vaccines and seroprotection in children who do not receive a booster dose of DTPa at this age, including protection against diphtheria until subsequent booster doses are given.
Murdoch Childrens Research Institute and Melbourne School of Population Health, The University of Melbourne, Victoria, Australia. t.nolan@unimelb.edu.au
Terry
T
Nolan
Tilman A
TA
Ruff
Stephen B
SB
Lambert
Jim
J
Buttery
Kerry-Ann
KA
O'Grady
Catherine
C
Streeton
Bernard
B
Hoet
Hans L
HL
Bock
D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000032:analysis*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000276:immunology*; D004311:Double-Blind Method; D006801:Humans; D007117:Immunization, Secondary; D007223:Infant; D016037:Single-Blind Method
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines