DNA-interaction and in vitro antimicrobial studies of some mixed-ligand complexes of cobalt(II) with fluoroquinolone antibacterial agent ciprofloxacin and some neutral bidentate ligands.
Six new mixed-ligand complexes of Co(II) with ciprofloxacin (Cip) and neutral bidentate ligands have been synthesized and characterized. Binding and cleavage of DNA with the complex were investigated using spectroscopic method, viscosity measurements and gel electrophoresis techniques. Antibacterial activity has been assayed against two Gram((-ve)) and three Gram((+ve)) microorganisms using the doubling dilution technique.
Patel
M N
MN
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India. jeenen@gmail.com
Chhasatia
M R
MR
Gandhi
D S
DS
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000138:chemical synthesis / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D053837:DNA Cleavage; D024841:Fluoroquinolones / Q000138:chemical synthesis / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D003035:Cobalt; D002939:Ciprofloxacin; D004247:DNA