Prion protein peptides as vaccines.
Investigations into the immunogenicity of the prion protein are ongoing. To combat its pathological isoform without affecting the cellular protein is a challenge in prion research. We here summarize the studies in which prion protein peptides have been used for immunization, to thus determine the most immunogenic parts of the prion protein.
Ghielmetti
M
M
Department for the Production of Diagnostic Reagents and Research, Blood Transfusion Centre of Slovenia, Slajmerjeva 6, 1000 Ljubljana, Slovenia.
Vranac
T
T
Curin Serbec
V
V
D000818:Animals; D000906:Antibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D003429:Cross Reactions; D018985:Epitopes, B-Lymphocyte / Q000276:immunology; D006801:Humans; D007114:Immunization / Q000379:methods*; D011328:Prions / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D022223:Vaccines, Subunit / Q000627:therapeutic use*
D000906:Antibodies; D018985:Epitopes, B-Lymphocyte; D011328:Prions; D022223:Vaccines, Subunit