In vitro evaluation of the antiplasmodial activity of Dendropanax morbifera against chloroquine-sensitive strains of Plasmodium falciparum.
Dendropanax morbifera Leveille (Araliaceae) is well known in Korea traditional medicine for a variety of diseases. The methanol extract of the lower stem parts of D. morbifera was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. Two cycloartane-type glycosides oleifoliosides A (1) and B (2), and dendropanoxide (3), beta-amyrin (4), alpha-amyrin (5) have been isolated from the stem parts of D. morbifera. All five compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell lines. Compounds 2 and 3 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values of 6.2 and 5.3 microm. This compound showed no significant cytotoxicity (IC(50) > 150 microm) evaluated using SK-OV-3 cancer cell lines. This is the first report on the antiplasmodial activity of the compounds from D. morbifera.
Chung
Ill-Min
IM
Department of Applied Life Science, Kon Kuk University, Seoul 143-701, South Korea.
Kim
Min-Young
MY
Park
Sun-Dong
SD
Park
Won-Hwan
WH
Moon
Hyung-In
HI
D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D027481:Araliaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002738:Chloroquine / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology
D000962:Antimalarials; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C546793:dendropanoxide; C546794:oleifolioside A; C546795:oleifolioside B; D009828:Oleanolic Acid; D002738:Chloroquine; C036380:beta-amyrin