Socio-behavioral characteristics of children with Rubinstein-Taybi syndrome.
Research regarding the behavioral aspects of children with Rubinstein-Taybi syndrome (RTS) has suggested some possible behavioral patterns including autistic features. Caregivers of 39 children (mean age = 8.4 years) with RTS (49% showing abnormality in CREBBP gene) and 39 children (mean age = 8.6 years) matched on developmental level, age and gender were administered the Child Behavior Checklist and the Children's Social Behavior Questionnaire. Children with RTS did not exhibit higher internalizing (affective and anxiety symptoms) or externalizing (disruptive symptoms) behavioral problems than expected for their age/developmental range. However, they displayed some specific behaviors: short attention span, motor stereotypies, poor coordination, and overweight. The presence of an identified CREBBP gene abnormality was possibly related to the motor difficulties through impaired motor skills learning.
Child Psychiatry Department, Centre Hospitalier Charles-Perrens, University Victor Segalen, Bordeaux 2, France. cedric.galera@u-bordeaux2.fr
Cédric
C
Galéra
Emmanuelle
E
Taupiac
Sonia
S
Fraisse
Sophie
S
Naudion
Eva
E
Toussaint
Caroline
C
Rooryck-Thambo
Marie-Ange
MA
Delrue
Benoit
B
Arveiler
Didier
D
Lacombe
Manuel-Pierre
MP
Bouvard
D000293:Adolescent; D001321:Autistic Disorder / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D050882:CREB-Binding Protein / Q000235:genetics*; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D010552:Personality Assessment / Q000706:statistics & numerical data; D010641:Phenotype; D011594:Psychometrics; D011596:Psychomotor Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D012415:Rubinstein-Taybi Syndrome / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D012919:Social Behavior; D013239:Stereotyped Behavior
D050882:CREB-Binding Protein; C494363:CREBBP protein, human