Pharmacokinetics of marbofloxacin after a single oral dose to loggerhead sea turtles (Caretta caretta).
The single-dose disposition kinetics of marbofloxacin (MBX) were determined in clinically healthy loggerhead sea turtles (n=5) after oral (PO) administration of 2 mg kg(-1) bodyweight. Marbofloxacin plasma concentrations were determined by DAD-HPLC (LOD/LOQ 0.015/0.05 microg ml(-1)). Data were subjected to non-compartmental analysis. Following PO administration, marbofloxacin achieved maximum plasma concentrations of 11.66+/-2.53 mg L(-1) at 15.00+/-3.00 h. The absence of general adverse reactions in the turtles of the study, and the favourable pharmacokinetic properties (long half-life and high maximum plasma concentration) of MBX administered PO at the single-dose of 2 mg kg(-1) suggest the possibility of its safe and effective clinical use in loggerhead sea turtles.
Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Murcia, Spain. pmarin@um.es
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Marín
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Lai
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Laricchiuta
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Marzano
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Di Bello
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Cárceles
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Crescenzo
D000284:Administration, Oral; D000820:Animal Diseases / Q000097:blood / Q000188:drug therapy; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D016908:Gram-Positive Bacterial Infections / Q000097:blood / Q000188:drug therapy / Q000662:veterinary; D007700:Kinetics; D014426:Turtles / Q000502:physiology*
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C080260:marbofloxacin