[Progress in the study of antitumor drug targeting on the Ras signaling pathway].
Ras signaling pathway is closely related to the formation and growth of tumor. Currently, targeting on this signaling pathway is a hot research point for the design and development of anticancer drugs. In this paper, Ras protein as well as its related targets and inhibitors in signaling pathway were reviewed. It is expected to give research-related reference materials for the design of new anticancer drugs.
Zhu
Yi-jing
YJ
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Jiang
Feng-chao
FC
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D015398:Signal Transduction / Q000187:drug effects*; D018631:ras Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology
D000970:Antineoplastic Agents; D018631:ras Proteins