Polyamide amino acids: a new class of RNA ligands.
This communication introduces a new class of promising RNA ligands, named polyamide amino acids (PAA), which are able to bind a targeted bulged stem-loop RNA fragment (HIV-1 TAR RNA) with micromolar affinities and with specificity comparative to dsDNA and tRNA; both the affinity and the specificity of PAA for TAR depend on their length and on the nature of the amino acid residues.
Bonnard
Vanessa
V
Laboratoire de Chimie des Molécules Bioactives et des Arômes, UMR 6001 CNRS UNSA, Institut de Chimie de Nice, Université de Nice Sophia Antipolis, 06108 Nice Cedex, France.
Azoulay
Stéphane
S
Di Giorgio
Audrey
A
Patino
Nadia
N
D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands; D015394:Molecular Structure; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D012313:RNA / Q000737:chemistry* / Q000378:metabolism*
D000596:Amino Acids; D008024:Ligands; D009757:Nylons; D012313:RNA