The clinical significance of neuroendocrine differentiation in T3-T4 node-negative colorectal cancer.
This study was conducted to determine the clinical significance of neuroendocrine differentiation in cases of T3-T4 node-negative colorectal cancer. Eighty-nine patients diagnosed with T3-T4 node-negative colorectal cancer who underwent curative resection were enrolled. Tumors expressing neuroendocrine markers were classified as either low expression (<or=2% cells staining positive for a neuroendocrine marker) or high expression (>2% cells staining positive for a neuroendocrine marker). Immunohistochemical staining for chromogranin A and synaptophysin revealed high expression in 27 (30.3%) and 69 (77.5%) of the 89 patients, respectively. All tumors that showed high expression of chromogranin A also displayed high expression of synaptophysin. With the exception of preoperative carcinoembryonic antigen, no statistically significant correlation was found between neuroendocrine differentiation and all other clinicopathologic variables. Analysis using the Kaplan-Meier method and multivariate Cox regression model demonstrated that neuroendocrine differentiation for chromogranin A and synaptophysin was not associated with disease-free survival. Therefore, neuroendocrine differentiation markers would not be useful variables for prognostic assessment of patients with T3-T4 node-negative colorectal cancer.
Cho
Yong Beom
YB
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Yang
Shin Suk
SS
Lee
Woo Yong
WY
Song
Sang Yong
SY
Kim
Seok-Hyung
SH
Shin
Hee Jung
HJ
Yun
Seong Hyeon
SH
Chun
Ho-Kyung
HK
D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D053379:Chromogranin A / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009490:Neurosecretory Systems / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D056910:Republic of Korea / Q000453:epidemiology; D015996:Survival Rate; D016708:Synaptophysin / Q000378:metabolism; D046888:Tissue Array Analysis; D055815:Young Adult
D014408:Biomarkers, Tumor; D053379:Chromogranin A; D016708:Synaptophysin