[The role of zinc in the homeostasis of the human organism].
The concentrations of essential metal ions in various compartments of the human body are accurately regulated (homeostasis). Irregularities in the accumulation or depletion of the trace elements may lead to well characterized diseases. This review covers the metabolism of zinc regulations by which the intracellular and extracellular levels are kept in physiological range, biological functions, as well as pathological states that develop in its altered metabolism. The focus is on the molecular mechanisms of zinc ion traffic between compartments of the body and cells and their sequestration, gene regulations that regulate the ion fluxes via biological membranes and their storage, zinc-mediated cell and tissue damages, and development of symptoms in zinc deficiency is also discussed.
Szentmihályi
Klára
K
Magyar Tudományos Akadémia, Kémiai Kutatóközpont Anyag- és Környezetkémiai Intézet, Budapest Pusztaszeri út 59-67., 1025. szklari@chemres.hu
Vinkler
Péter
P
Fodor
Judit
J
Balla
József
J
Lakatos
Béla
B
D000747:Anemia, Hypochromic / Q000139:chemically induced; D019587:Dietary Supplements; D006706:Homeostasis; D006801:Humans; D007408:Intestinal Absorption; D008668:Metallothionein / Q000378:metabolism; D015398:Signal Transduction; D014131:Trace Elements / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D015032:Zinc / Q000008:administration & dosage / Q000009:adverse effects / Q000172:deficiency / Q000378:metabolism* / Q000502:physiology
D014131:Trace Elements; D008668:Metallothionein; D015032:Zinc