[Severe drug hypersensitivity syndrome due to sulphasalazine in patient with rheumatoid arthritis].
Drug Hypersensitivity Syndrome, also known as Drug Rash with Eosinophilia and Systemic Symptoms is a severe adverse reaction characterized by clinical manifestations including fever, skin eruption, lymphoadenopathy, associated with eosinophilia, leukocytosis and multiple visceral involvement, with 10% of mortality due to development of multiple organ failure. This reaction usually occurs between two and six-eight weeks after the beginning of the treatment and may not resolve with interruption of the suspected drug. Sulfonamides, anticonvulsant, allopurinol are the most frequently involved molecules, but recently cases have been described also with gabapentin and strontium ranelate. In the present report we describe a case of a patient with rheumatoid arthritis who presented severe drug hypersensitivity syndrome, with liver and kidney involvement due to sulphasalazine.
Clinica Reumatologica, Università Politecnica delle Marche, Ospedale "A. Murri", Jesi, Ancona, Italia. dr.gmarwin@gmail.com
M
M
Gutierrez
E
E
Filippucci
L
L
Bugatti
C
C
Bertolazzi
W
W
Grassi
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D012074:Remission Induction; D012460:Sulfasalazine / Q000008:administration & dosage / Q000009:adverse effects*; D013577:Syndrome; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D005938:Glucocorticoids; D012460:Sulfasalazine; D008775:Methylprednisolone