Synthesis of fluorinated beta-ketosulfones and gem-disulfones by nucleophilic fluoroalkylation of esters and sulfinates with di- and monofluoromethyl sulfones.
An efficient and practically useful method for the preparation of alpha-functionalized mono- and difluoro(phenylsulfonyl)methanes by using a nucleophilic fluoroalkylation methodology was developed. Alpha,alpha-difluoro-beta-ketosulfones, alpha-monofluoro-beta-ketosulfones, and alpha-fluoro disulfones were successfully prepared in excellent yields by nucleophilic fluoroalkylation of esters and sulfinates with PhSO(2)CF(2)H and PhSO(2)CH(2)F reagents.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.
Chuanfa
C
Ni
Laijun
L
Zhang
Jinbo
J
Hu