Approach to suspected food allergy in atopic dermatitis. Guideline of the Task Force on Food Allergy of the German Society of Allergology and Clinical Immunology (DGAKI) and the Medical Association of German Allergologists (ADA) and the German Society of Pediatric Allergology (GPA).
The following guideline of the "Arbeitsgruppe Nahrungsmittelallergie der DGAKI" (Task Force on Food Allergy of the German Society of Allergology and Clinical Immunology) and the ADA ("Arzteverband Deutscher Allergologen", Medical Association of German Allergologists) and the GPA (German Society of Pediatric Allergology) summarizes the approach to be taken when food allergy is suspected in patients with atopic dermatitis (neurodermatitis, atopic eczema). The problem is clinically relevant because many patients assume that allergic reactions against foods are responsible for triggering or worsening their eczema. It is important to identify those patients who will benefit from an elimination diet but also to avoid unnecessary diets. Elimination diets (especially in early childhood) are associated with the risk of malnutrition and additional emotional stress for the patients. The gold standard for the diagnosis of food-dependent reactions is to perform placebo-controlled, double-blind oral food challenges because specific IgE, prick tests and history often do not correlate with clinical reactivity. This is particularly true in the case of delayed eczematous skin reactions. Diagnostic elimination diets should be used before an oral provocation test. If multiple sensitizations against foods are discovered in a patient, an oligoallergenic diet and a subsequent stepwise supplementation of the nutrition should be performed. If a specific food is suspected of triggering food allergy, oral provocation should be performed after a diagnostic elimination diet. As eczema-tous skin reactions may develop slowly (i. e. within one or two day), the skin be inspected the day after the provocation test and that a repetitive test be performed if the patient has not reacted to a given food on the first day of oral provocation. The guideline discusses various clinical situations for patients with atopic dermatitis to facilitate differentiated diagnostic procedures.
Department of Dermatology and Venereology, Hannover Medical School, Ricklinger StraBe 5, Hannover D-30449, Germany. Werfel.thomas@mh-hannover.de
Thomas
T
Werfel
Stephan
S
Erdmann
Thomas
T
Fuchs
Margot
M
Henzgen
Jörg
J
Kleine-Tebbe
Ute
U
Lepp
Bodo
B
Niggemann
Martin
M
Raithel
Imke
I
Reese
Joachim
J
Saloga
Stefan
S
Vieths
Torsten
T
Zuberbier
D000486:Allergy and Immunology / Q000592:standards*; D003876:Dermatitis, Atopic / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D005512:Food Hypersensitivity / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D005858:Germany