Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch.
Transformation from follicular lymphoma (FL) to high-grade B-cell lymphoma/leukemia (BLL) has been reported in patients with additional translocations involving the c-MYC gene. The previously reported cases were related to t(8;14) and t(8;22) but not to t(2;8). Herein is reported an FL that terminated in BLL following additional t(2;8). In accordance with previous reports, increased expression of c-MYC was observed in the present case but, interestingly, BCL-2 expression was inversely decreased after the transformation. In addition, the cell-surface immunoglobulin light-chain of lymphoma cells was initially kappa type and was then gradually replaced with the lambda type after transformation. Downregulation of BCL-2 and light-chain switch have rarely been reported in previous cases of FL transformation involving c-MYC, suggesting that additional t(2;8) translocation may play a role in these events.
Mannouji
Kiyohito
K
Division of Hematology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan.
Tasaka
Taizo
T
Akiyama
Takashi
T
Irei
Isao
I
Sano
Fuminori
F
Matsuhashi
Yoshiko
Y
Wada
Hideho
H
Tohyama
Kaoru
K
Sugihara
Takashi
T
Sadahira
Yoshito
Y
D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations; D002889:Chromosomes, Human, Pair 2; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005434:Flow Cytometry; D016259:Genes, myc / Q000235:genetics; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000276:immunology*; D007150:Immunohistochemistry; D008224:Lymphoma, Follicular / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis* / Q000235:genetics; D014178:Translocation, Genetic
D014408:Biomarkers, Tumor; D007147:Immunoglobulin Light Chains; C489427:MYC protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc