Evaluation of Artemisia annua infusion efficacy for the treatment of malaria in Plasmodium chabaudi chabaudi infected mice.
The efficacy of artemisinin (AR) against malaria has prompted its use as a tea drink in endemic communities. However, there is controversy about its efficacy in this form. Therefore we have investigated the effectiveness of Artemisia annua infusion in infected mice. OF1 mice infected with Plasmodium chabaudi chabaudi were treated for upto 6 days by administration of: water (control group), A. annua infusion (tea group), 0.022 mg AR (AR-equiv. group) and 0.8 mg AR on the first day and 0.4 mg the following day (AR-WHO group). Initially, the parasitaemia increased in all groups. On day 4 it reached 75% in the control group, 72% in the AR-equiv. group, 50% in the tea group and 3% in the AR-WHO group. Mice treated with A. annua tea died after 11 days, while 83% of AR-WHO dose survived. The tea does not decrease the parasitaemia fast enough. We suggest that large clinical trials on human subjects are necessary to ascertain the efficacy of standardized tea. Additionally, other treatment possibilities are suggested.
Atemnkeng
Magnus A
MA
Pharmaceutical Institute, Department of Pharmaceutical Technology and Physical Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.
Chimanuka
Bantuzeko
B
Dejaegher
Bieke
B
Heyden
Yvan Vander
YV
Plaizier-Vercammen
Jacqueline
J
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use; D031172:Artemisia annua / Q000737:chemistry*; D037621:Artemisinins / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use; D001628:Beverages / Q000032:analysis; D002855:Chromatography, Thin Layer; D003720:Densitometry; D004195:Disease Models, Animal; D005260:Female; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D016788:Plasmodium chabaudi / Q000187:drug effects*
D000890:Anti-Infective Agents; D037621:Artemisinins; C031327:artemisinin