Age-related changes of sex hormones--level among males in populations with high index of longevity.
The phenomenon of longevity as a kind of model of "physiological" aging has been the main research subject of the Department of Gerontology Institute of Morphology (Georgia) since 1970. The researches were conducted under the Multiplan complex program "Bio-anthropological and social and ethnic investigation of nations and ethnic groups with high index of longevity" in the "long-liver" populations of Georgia. The research aimed at studying the changes in the content of the sex steroids and gonadotrophic hormones in the blood plasma of the healthy men aged from 45 to 90 and more years and residing in Georgia. The control reference group consisted of healthy man, aged from 22 to 35 years. In the blood of patients of all age groups there was observed the fall of the testosterone concentration by 34-55% as compared to the control group and growth of the content of luteinizing hormones by 1-10%. There was not observed falling of the testosterone concentration below the normal limits in any age group (11 nmol/l). Therefore, syndrome of partial progressive insufficiency of the androgens is the reality and requires clear therapeutic treatment attitudes and development of substitutive hormonotherapy.
Dalakishvili
S
S
Al. Natishvili Institute of Morphology, Tbilisi, Georgia.
Didebulidze
N
N
Sumbadze
Ts
Ts
Akuradze
N
N
Melikadze
E
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004958:Estradiol / Q000097:blood*; D006801:Humans; D008136:Longevity; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone