Lipid, inflammatory and haemorheological profiles are significantly affected by farmed fish eating: an intervention study.
OBJECTIVE
The objective of the present study was to evaluate the influence of short-term dietary intake of farmed fish on biomarkers related to the atherosclerotic process.


RESULTS
Lipid, inflammatory, and haemorheological variables before (T0) and after a dietary intervention with about 800 g Orbetello farmed sea bass per week for 10 weeks (T1) were evaluated in nine dyslipidemic subjects. Fish intake significantly decreased triacylglycerols (T1, 140.2+/-20.3 mg/dl versus T0, 183.3+/-29.2 mg/dl; P =0.04), whereas no significant changes for the other lipid variables have been observed. Moreover, dietary intervention significantly (P <0.05) decreased all of the inflammatory parameters investigated; namely, high-sensitivity C-reactive protein, interleukin-6, and interleukin-8. Furthermore, a significant (P =0.04) improvement in erythrocytes' deformability index was reported after 10 weeks of fish dietary intake (9.0+/-0.7% versus 5.4+/-1.0% for T1 and T0, respectively).


CONCLUSIONS
Dietary short-term intake of farmed fish seems to impose favourable biochemical changes in dyslipidemic subjects.
Sofi
Francesco
F
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, Florence, Italy. francescosofi@gmail.com
Gori
Anna Maria
AM
Cesari
Francesca
F
Paniccia
Rita
R
Mannini
Lucia
L
Giorgi
Gianluca
G
Parisi
Giuliana
G
Casini
Alessandro
A
Poli
Bianca Maria
BM
Gensini
Gian Franco
GF
Abbate
Rosanna
R
D000328:Adult; D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control; D001492:Bass; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D050171:Dyslipidemias / Q000097:blood* / Q000178:diet therapy*; D004907:Erythrocyte Deformability; D005260:Female; D005398:Fisheries; D018056:Hemorheology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007378:Interleukins / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017747:Seafood; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D018836:Inflammation Mediators; D007378:Interleukins; D008055:Lipids; D014280:Triglycerides; D002097:C-Reactive Protein