Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease.
The effects of Poncirus trifoliata (P. trifoliata) (Ponciri Fructus, PF) extract and its constituents such as neohesperidin and poncirin on gastritis in rats and human gastric cancer cells were investigated. The PF 70% ethanol extracts (1 g) showed approximately 11.38% of acid-neutralizing capacities and cytotoxicity (IC50=85.39 microg/mL) against human AGS gastric cancer cells. In addition, neohesperidin exhibited antioxidant activity (IC50=22.31 microg/mL) in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. Neohesperidin (50 mg/kg) and poncirin (100 mg/kg) significantly inhibited 55.0% and 60.0% of HCl/ethanol-induced gastric lesions, respectively, and increased the mucus content. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. From these results, it could be suggested that neohesperidin and poncirin isolated from PF may be useful for the treatment and/or protection of gastritis.
Lee
Je-Hyuk
JH
Plant Resources Research Institute, Duksung Women's University, Seoul 132-714, Korea.
Lee
Seung-Ho
SH
Kim
Yeong Shik
YS
Jeong
Choon Sik
CS
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D005756:Gastritis / Q000188:drug therapy*; D006569:Hesperidin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D032104:Poncirus / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D000897:Anti-Ulcer Agents; D000975:Antioxidants; D005419:Flavonoids; D010936:Plant Extracts; C119641:poncirin; D006569:Hesperidin; C546526:neohesperidin