Reliability of the proposed international classification of high-resolution computed tomography for occupational and environmental respiratory diseases.
OBJECTIVE
We have developed a classification of high-resolution computed tomography (HRCT) images for screening, surveillance and epidemiological studies of respiratory diseases caused by occupational and environmental factors. The proposed classification consists of three parts: a guideline explaining the elements of the classification scheme, a reading sheet, and reference films to aid in assessing thin-section CT films. We assessed the reliability of the proposed classification system by blinded, independent trial reading.


METHODS
Seven independent radiologists and pulmonologists performed a trial reading to measure the reliability of the classification system using HRCT films from 27 pneumoconiosis patients and 7 normal controls.


RESULTS
The agreement was moderate to good for rounded opacities (weighted kappa=0.68 and 0.64), irregular opacities (0.59, 0.48), honeycombing (0.65, 0.47), emphysema (0.76, 0.62) and large opacities (0.48, 0.52). Ground glass opacities (0.16, 0.20) showed poor to fair agreement. Intra-reader agreement of each of the seven readers was moderate to good (mean: weighted kappa=0.52-0.80) for parenchymal findings, but the agreement was relatively low (mean weighted kappa=0.52) for ground glass opacities.


CONCLUSIONS
The proposed classification is able to describe early dust-related fibrotic changes and provide a semi-quantitative description of the HRCT features of major fibrotic changes in the parenchyma and pleura. Reliability, as measured by inter-reader agreement, was satisfactory.
Suganuma
Narufumi
N
Department of Environmental Medicine, Kochi Medical School. Kohasu, Nankoku, Japan. nsuganuma@kochi-u.ac.jp
Kusaka
Yukinori
Y
Hering
Kurt G
KG
Vehmas
Tapio
T
Kraus
Thomas
T
Arakawa
Hiroaki
H
Parker
John E
JE
Kivisaari
Leena
L
Letourneux
Marc
M
Gevenois
Pierre A
PA
Tuengerthal
Siegfreud
S
Crane
Michael D
MD
Shida
Hisao
H
Akira
Masanori
M
Henry
Daniel A
DA
Nakajima
Yasuo
Y
Hiraga
Yohmei
Y
Itoh
Harumi
H
Hosoda
Yutaka
Y
D006801:Humans; D038622:Internationality; D008171:Lung Diseases / Q000000981:diagnostic imaging*; D009784:Occupational Diseases; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000145:classification*