Highly efficient synthesis of vinyl substituted triazoles by Au(I) catalyzed alkyne activation.
Au(I) catalyzed 1,2,3-triazole addition to non-activated alkyne was reported. A large group of substituted NH-1,2,3-triazoles were suitable for this transformation along with both internal and terminal alkynes. The N-1 and N-2 vinyl substituted 1,2,3-triazoles were prepared in up to 98% yield with as low as 0.2% catalyst loading, thereby providing a new protocol for the synthesis of potentially biological-active vinyl-triazole building blocks.
C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV 26506, USA.
Haifeng
H
Duan
Wuming
W
Yan
Sujata
S
Sengupta
Xiaodong
X
Shi
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D014230:Triazoles; D006046:Gold