The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment.
Emerging evidence points towards a key role of the extracellular matrix (ECM) during tumor progression and therapy resistance. Paradoxically, in today's routine of cancer management the ECM is not taken into account. It is the aim of the present review to broaden our understanding of the mechanisms of therapy resistance, taking the ECM as a presumptive central regulator. The stromal ecosystem drives the accumulation of ECM at the invasion front. Therefore, we address the question whether the detection of ECM signatures in histopathology and biofluids may help predicting therapy resistance and determining the prognosis of cancer. Since the ECM is an attractive target for tumor therapy, current therapeutic strategies in preclinical or clinical development will be discussed.
Denys
Hannelore
H
Department of Medical Oncology, Ghent University Hospital, 9000 Ghent, Belgium.
Braems
Geert
G
Lambein
Kathleen
K
Pauwels
Patrick
P
Hendrix
An
A
De Boeck
Astrid
A
Mathieu
Véronique
V
Bracke
Marc
M
De Wever
Olivier
O
D000818:Animals; D018450:Disease Progression; D005109:Extracellular Matrix / Q000473:pathology* / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy*; D011379:Prognosis; D015398:Signal Transduction / Q000502:physiology
D016326:Extracellular Matrix Proteins