Two unusual naphthalene-containing compounds from a freshwater fungus YMF 1.01029.
Two novel naphthalene-containing compounds, colelomycerones A and B (1 and 2, resp.), and three known metabolites, including preussomerin D (3), (2RS,2'SR,3'E,3SR,4E,8E)-1-O-(beta-D-glucopyranosyl)-3-hydroxy-2-[(2-hydroxyoctadec-3-enoyl)amino]-9-methyloctadeca-4,8-diene (4), and 3beta-hydroxy-5alpha,8alpha-epidioxyergosta-6,22-diene (5), were isolated from the culture broth of an unidentified freshwater water fungus YMF 1.01029. This fungus was collected from a decaying branch of an unidentified tree near Lake Fuxian in Yunnan Province, China. The structures of these five compounds were determined on the basis of their spectroscopic and mass-spectrometric data. Colelomycerones A and B (1 and 2, resp.) represent unprecendented examples of naphthalene-1,2-diones with novel cyclic acetals. Compounds 1-3 showed noticeable antifungal and antibacterial activities.
Dong
Jin-Yan
JY
Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory for Microbial Resources of the Chinese Ministry of Education, Yunnan University, Kunming 650091, P. R. China.
Song
Hong-Chuan
HC
Li
Jian-Hua
JH
Wang
Chun-Ren
CR
Sun
Rong
R
Tang
Yu-Shu
YS
Shen
Kai-Ze
KZ
Wang
Le
L
Wang
Li-Mei
LM
Zhou
Yong-Ping
YP
Li
Lei
L
Zhang
Ke-Qin
KQ
D000080:Acetals / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002850:Chromatography, Gel; D005658:Fungi / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000080:Acetals; D000900:Anti-Bacterial Agents; D009281:Naphthalenes; C541293:colelomycerone A; C541292:colelomycerone B; C031721:naphthalene