CARD9 versus CARMA1 in innate and adaptive immunity.
Nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPKs) are activated upon engagement of a wide variety of immunoreceptors. Accumulating evidence has demonstrated that B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue (MALT1) are essential signaling components for NF-kappaB and MAPK activation mediated by immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors in both adaptive and innate immunity. Recent studies have revealed that two caspase-recruitment domain (CARD) family adaptor molecules, CARD-containing MAGUK protein 1 (CARMA1) and CARD9, are crucial regulators of the ITAM-mediated signaling pathway by forming a complex with BCL10-MALT1 in lymphoid and myeloid cells, respectively. Here, we describe the immune responses and the cell-type-specific regulation mechanisms for NF-kappaB and MAPK activation controlled by CARMA1 and CARD9 through innate and adaptive immunoreceptors.
Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. harah@cc.saga-u.ac.jp
Hiromitsu
H
Hara
Takashi
T
Saito
D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology; D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D053468:CARD Signaling Adaptor Proteins / Q000276:immunology*; D006162:Guanylate Cyclase / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology*
D048868:Adaptor Proteins, Signal Transducing; D053468:CARD Signaling Adaptor Proteins; C505855:CARD9 protein, human; C496467:Card11 protein, mouse; C513280:Card9 protein, mouse; C426242:CARD11 protein, human; D006162:Guanylate Cyclase