Caveolins in the development and diseases of musculoskeletal system.
Caveolins, essential scaffold proteins of caveolae, have emerged as versatile molecules that can influence numerous signaling pathways and disease processes. This brief review is focused on the role of caveolins in the physiology and pathology of musculoskeletal system and will discuss the key features of caveolins as related to differentiation and diseases of bone and muscle cells.
Department of Musculoskeletal Oncology, Oncologic Research Laboratory, Servizio Sanitario Regionale Emilia-Romagna, Istituto Ortopedici Rizzoli, IRCCS, Via di Barbiano 1/10, 40136 Bologna, Italy.
Massimo
M
Serra
Katia
K
Scotlandi
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D001859:Bone Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D021941:Caveolae / Q000502:physiology / Q000648:ultrastructure; D022461:Caveolins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation; D018432:Drug Resistance, Multiple / Q000502:physiology; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D032342:Muscle Cells / Q000378:metabolism; D024510:Muscle Development / Q000502:physiology; D019042:Muscle Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D009140:Musculoskeletal Diseases / Q000378:metabolism* / Q000473:pathology; D010006:Osteoblasts / Q000378:metabolism / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology
D000970:Antineoplastic Agents; D022461:Caveolins