Coats' disease, megalopapilla and Cornelia de Lange syndrome.
Cornelia de Lange syndrome (CdLS), a congenital disorder characterized by growth and mental retardation, hirsutism, and skeletal and cardiac anomalies, has been associated with a number of ophthalmic abnormalities including synophrys, long eyelashes, myopia, nasolacrimal duct obstruction, and ptosis. Only one case of Coats' disease has been described in the setting of this syndrome.(1) We describe a second case of Coats' disease in a five-year-old boy with this condition.
Cleveland Clinic Foundation, Cleveland Clinic, Cole Eye Institute, Cleveland, Ohio 44195, USA.
Mark R
MR
Barakat
Elias I
EI
Traboulsi
Jonathan E
JE
Sears
D002675:Child, Preschool; D003635:De Lange Syndrome / Q000150:complications* / Q000175:diagnosis; D005122:Exudates and Transudates; D005124:Eye Abnormalities / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D009898:Optic Disk / Q000002:abnormalities*; D012173:Retinitis / Q000150:complications* / Q000175:diagnosis; D013684:Telangiectasis / Q000150:complications* / Q000175:diagnosis