Cognitive and mood effects of 8 weeks' supplementation with 400 mg or 1000 mg of the omega-3 essential fatty acid docosahexaenoic acid (DHA) in healthy children aged 10-12 years.
BACKGROUND
Despite media and public expectation of efficacy, no study to date has investigated the cognitive and mood effects of omega 3 supplementation in healthy children.


METHODS
This randomised, double-blind, placebo-controlled, parallel groups pilot study assessed the cognitive and mood effects of either 400 mg or 1000 mg of docosahexaenoic acid (DHA) in 90 healthy children aged 10-12 years. Cognitive performance and mood was assessed prior to, and 8 weeks following, commencement of treatment.


RESULTS
There was a significant treatment effect on one cognitive measure (speed of word recognition), with the lower dose speeding, and the higher dose slowing, performance. Overall, the pattern of results strongly suggests that this effect was due to chance fluctuations in performance and that the treatments had no consistent or interpretable effect on performance.


CONCLUSIONS
The results here do not suggest that supplementation with these doses of DHA for 8 weeks has any beneficial effect on brain function in cognitively intact children.
Kennedy
David O
DO
Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, UK. david.kennedy@unn.ac.uk
Jackson
Philippa A
PA
Elliott
Jade M
JM
Scholey
Andrew B
AB
Robertson
Bernadette C
BC
Greer
Joanna
J
Tiplady
Brian
B
Buchanan
Tom
T
Haskell
Crystal F
CF
D000339:Affect / Q000187:drug effects*; D002648:Child; D003071:Cognition / Q000187:drug effects*; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D010919:Placebos; D011930:Reaction Time
D010919:Placebos; D004281:Docosahexaenoic Acids