Association of pancreatic autoantibodies and human leukocyte antigen haplotypes with resolution of diabetes mellitus after therapy for hepatitis C virus infection in patients with HIV infection: case report and review of literature.
Diabetes mellitus (DM) is a well known complication of interferon therapy for chronic hepatitis C virus (HCV) infection, but resolution of interferon-induced DM was rarely reported. In HIV and HCV co-infected patients, only two cases of incident DM during interferon therapy were reported and both cases required permanent insulin treatment. We report the first case of HIV/HCV co-infected patient who developed diabetic ketoacidosis during treatment for chronic HCV infection with complete resolution of DM after treatment cessation. Review of reported cases indicates that pancreatic autoantibodies and human leukocyte antigen haplotypes may predict the outcome of interferon-induced diabetes.
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yi-Chun
YC
Lo
Sui-Yuan
SY
Chang
Wang-Huei
WH
Sheng
Chien-Ching
CC
Hung
Shan-Chwen
SC
Chang
D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D001323:Autoantibodies / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced* / Q000235:genetics / Q000276:immunology; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006681:HLA-D Antigens / Q000235:genetics; D006239:Haplotypes; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D010179:Pancreas / Q000276:immunology; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011994:Recombinant Proteins; D012075:Remission, Spontaneous
D000998:Antiviral Agents; D001323:Autoantibodies; D006681:HLA-D Antigens; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C100416:peginterferon alfa-2a