Structural enzymology of polyketide synthases.
This chapter describes structural and associated enzymological studies of polyketide synthases, including isolated single domains and multidomain fragments. The sequence-structure-function relationship of polyketide biosynthesis, compared with homologous fatty acid synthesis, is discussed in detail. Structural enzymology sheds light on sequence and structural motifs that are important for the precise timing, substrate recognition, enzyme catalysis, and protein-protein interactions leading to the extraordinary structural diversity of naturally occurring polyketides.
Department of Molecular Biology, University of California, Irvine, California, USA.
Shiou-Chuan Sheryl
SC
Tsai
Brian Douglas
BD
Ames
D064429:Fatty Acid Synthases / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D048630:Polyketide Synthases / Q000737:chemistry* / Q000378:metabolism*; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology
D048630:Polyketide Synthases; D064429:Fatty Acid Synthases