Sources of unreliability in the diagnosis of substance dependence.
OBJECTIVE
The Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) yields Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnoses for a variety of psychiatric disorders, including alcohol and drug dependence. Using generalizability theory, we sought to ascertain the sources of unreliability for DSM-IV substance-dependence diagnoses and their criterion counts.


METHODS
Two hundred ninety-three subjects (52.2% women) were interviewed twice over a 2-week period, and a generalizability coefficient and an index of dependability (with confidence intervals) were calculated for each dependence category.


RESULTS
Overall, there were good-to-excellent reliabilities for the more common diagnoses and criterion counts, including tobacco, alcohol, cocaine, and opioid dependence. The reliabilities were not as good for marijuana dependence and the less common diagnoses of stimulant, sedative, and other drug dependence. There was greater variability between interviewers (inter-rater reliability) than occasions (test-retest reliability). However, for most diagnoses, the subject by occasion variability was larger than the subject by interviewer variability, indicative of greater consistency in the contribution by interviewers to the ordering of subjects than in the contribution by subjects themselves between the two interviews.


CONCLUSIONS
These results are consistent with prior findings that the SSADDA yields reliable diagnoses and criterion counts for the more prevalent substance-dependence diagnoses. The present analysis extends these findings by showing that the greatest source of unreliability was the subjects' report. This underscores the need for efforts to increase the reliability of substance-dependence diagnoses (and by extension other self-reported phenotypic features) by enhancing the consistency of the information provided by the subjects interviewed.
Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare Center and Yale University School of Medicine, West Haven, Connecticut 06516, USA.
Richard
R
Feinn
Joel
J
Gelernter
Joseph F
JF
Cubells
Lindsay
L
Farrer
Henry R
HR
Kranzler
D000328:Adult; D016022:Case-Control Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D015233:Models, Statistical; D015588:Observer Variation; D015203:Reproducibility of Results; D019966:Substance-Related Disorders / Q000175:diagnosis*