Colobronchial fistula: an unusual complication after peritonectomy and hyperthermic intra-peritoneal chemotherapy (HIPEC).
BACKGROUND
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is an innovative approach to peritoneal carcinomatosis. Due to the complexity of the combined procedure, high rates of potentially life-threatening complications have been reported. This is the first report of colobronchial fistula following CRS and HIPEC.


METHODS
A 70-year-old woman underwent CRS and HIPEC for papillary well-differentiated peritoneal mesothelioma. During the postoperative course, recurrent pneumonia occurred and bacteria of intestinal origin were isolated from expectorated sputum. Water-soluble contrast studies revealed direct communication between the left colon flexure and the bronchial tree. After appropriate medical and supportive therapies, the patient underwent resection of the splenic flexure and immediate anastomosis with complete recovery.


CONCLUSIONS
Colobronchial fistula is a rare and potentially lethal complication of CRS and HIPEC. A suggestive clinical picture and contrast studies allow conclusive diagnosis to be made. Surgery is a safe and effective therapeutic option.
Laterza
Barbara
B
Department of Surgery, National Cancer Institute, Milan, Italy.
Baratti
Dario
D
Cozzi
Guido
G
Kusamura
Shigeki
S
Oliva
Grazia Daniela
GD
Gavazzi
Cecilia
C
Fumagalli
Luca
L
Sironi
Alessandro
A
Sabia
Domenico
D
Deraco
Marcello
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001983:Bronchial Fistula / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D003106:Colon; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D007412:Intestinal Fistula / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D008654:Mesothelioma / Q000473:pathology / Q000628:therapy*; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000628:therapy*; D010537:Peritoneum / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology; D011859:Radiography; D016896:Treatment Outcome