Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome.
The relative influence of genetics and the environment on factors associated with cardiovascular disease (CVD) and metabolic syndrome (MetS) remains unclear. We performed model-fitting analyses to quantify genetic, common environmental, and unique environmental variance components of factors associated with CVD and MetS [waist circumference, blood pressure, fasting plasma glucose and insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and fasting plasma lipids] in adult male and female monozygotic twins reared apart or together. We also investigated whether MetS components share common influences. Plasma cholesterol and triglyceride concentrations were highly heritable (56-77%, statistically significant). Waist circumference, plasma glucose and insulin, HOMA-IR, and blood pressure were moderately heritable (43-57%, statistically significant). Unique environmental factors contributed to the variance of all variables (20-38%, perforce statistically significant). Common environmental factors contributed 23, 30, and 42% (statistically significant) of the variance of waist circumference, systolic blood pressure, and plasma glucose, respectively. Two shared factors influenced MetS components; one influenced all components except HDL cholesterol, another influenced only lipid (triglyceride and HDL cholesterol) concentrations. These results suggest that genetic variance has a dominant influence on total variance of factors associated with CVD and MetS and support the proposal of one or more underlying pathologies of MetS.
Elder
Sonya J
SJ
Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Lichtenstein
Alice H
AH
Pittas
Anastassios G
AG
Roberts
Susan B
SB
Fuss
Paul J
PJ
Greenberg
Andrew S
AS
McCrory
Megan A
MA
Bouchard
Thomas J
TJ
Saltzman
Edward
E
Neale
Michael C
MC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D003430:Cross-Sectional Studies; D004734:Energy Metabolism; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D012307:Risk Factors; D014430:Twins, Monozygotic / Q000235:genetics / Q000378:metabolism; D055815:Young Adult