International Research Symposium on Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome.
Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome (Hay-Wells syndrome, MIM #106220) is a rare autosomal dominant ectodermal dysplasia syndrome. It is due to mutations in the TP63 gene, known to be a regulatory gene with many downstream gene targets. TP63 is important in the differentiation and proliferation of the epidermis, as well as many other processes including limb and facial development. It is also known that mutations in TP63 lead to skin erosions. These erosions, especially on the scalp, are defining features of AEC syndrome and cause significant morbidity and mortality in these patients. It was this fact that led to the 2003 AEC Skin Erosion Workshop. That conference laid the groundwork for the International Research Symposium for AEC Syndrome held at Texas Children's Hospital in 2006. The conference brought together the largest cohort of individuals with AEC syndrome, along with a multitude of physicians and scientists. The overarching goals were to define the clinical and pathologic findings for improved diagnostic criteria, to obtain tissue samples for further study and to define future research directions. The symposium was successful in accomplishing these aims as detailed in this conference report. Following our report, we also present 11 manuscripts within this special section that outline the collective clinical, pathologic, and mutational data from 18 individuals enrolled in the concurrent Baylor College of Medicine IRB-approved protocol: Characterization of AEC syndrome. These collaborative findings will hopefully provide a stepping-stone to future translational projects of TP63 and TP63-related syndromes.
The National Foundation for Ectodermal Dysplasias, Mascoutah, Illinosis.
Mary
M
Fete
Hans
H
vanBokhoven
Suzanne E
SE
Clements
Frank
F
McKeon
Dennis R
DR
Roop
Maranke I
MI
Koster
Caterina
C
Missero
Laura D
LD
Attardi
Vivian A
VA
Lombillo
Edward
E
Ratovitski
Meena
M
Julapalli
Derek
D
Ruths
Virginia P
VP
Sybert
Elaine C
EC
Siegfried
Alanna F
AF
Bree
D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D002972:Cleft Palate / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D004476:Ectodermal Dysplasia / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D005143:Eyelids / Q000002:abnormalities*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009154:Mutation; D013577:Syndrome; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics
C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins