[Effect of peptone blocking asbestos-induced carcinogenesis in rats].
Regular intraperitoneal administration of peptone to rats was initiated immediately and 12 months after intraperitoneal thrice injection of crokidolite UICC in a dose of 20 mg. The rate of peritoneal mesotheliomas was 37.8% after co-administration of peptone and crokidolite, 25.6% following 12 months of crokidolite injection, and 72.1% after use of crokidolite alone. The effect of peptone administration is accounted for by the action of macrophages on transformed mesothelial cells and mesothelioma cells.
L N
LN
Pylev
O V
OV
Smirnova
L A
LA
Vasil'eva
D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D015197:Carcinogenicity Tests; D004195:Disease Models, Animal; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D010461:Peptones / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar
D010461:Peptones; D001194:Asbestos