The price of the precautionary principle: cost-effectiveness of BSE intervention strategies in The Netherlands.
Since 1996, bovine spongiform encephalopathy (BSE) in cattle has been linked to a new variant of Creutzfeldt-Jakob disease (vCJD), a fatal brain disease in man. This paper assessed the cost-effectiveness of BSE control strategies instituted by the European Commission. In a Monte Carlo simulation model, a non-intervention baseline scenario was compared to three intervention strategies: removal of specified risk materials from slaughter animals, post-mortem testing for BSE and the culling of feed and age cohorts of BSE cases. The food risk in the baseline scenario ranged from 16.98 lost life years in 2002 to 2.69 lost life years in 2005. Removing specified risk materials removal practices, post-mortem testing and post-mortem testing plus cohort culling reduced this risk with 93%, 82.7% and 83.1%. The estimated cost-effectiveness of all BSE measures in The Netherlands ranged from 4.3 million euros per life year saved in 2002 to 17.7 million euros in 2005. It was discussed that the cost-effectiveness of BSE control strategies will further deviate from regular health economics thresholds as BSE prevalence and incidence declines.
Interfaculty Institute for Risk Assessment Sciences (IRAS), Division of Veterinary Public Health (VPH), Utrecht University, The Netherlands.
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Benedictus
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Hogeveen
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D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002417:Cattle; D003198:Computer Simulation; D003362:Cost-Benefit Analysis; D016643:Encephalopathy, Bovine Spongiform / Q000191:economics* / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D037901:Euthanasia, Animal / Q000706:statistics & numerical data*; D005260:Female; D005506:Food Contamination / Q000032:analysis / Q000517:prevention & control; D008297:Male; D009010:Monte Carlo Method; D009426:Netherlands; D011328:Prions / Q000032:analysis*; D018571:Sentinel Surveillance / Q000662:veterinary; D013269:Stochastic Processes
D011328:Prions