Boron biodistribution study in colorectal liver metastases patients in Argentina.
Ex-situ BNCT for multifocal unresectable liver metastases employing whole or partial autograft techniques requires knowledge of boron concentrations in healthy liver and metastases following perfusion and immersion in Wisconsin solution (W), the procedure employed for organ preservation during ex-situ irradiation. Measurements of boron concentration in blood, liver and metastases following an intravenous infusion of BPA-F in five colorectal liver metastases patients scheduled for surgery were performed. Tissue samples were evaluated for boron content pre and post perfusion and immersion in W. Complementary histological studies were performed. The data showed a dose-dependent BPA uptake in liver, a boron concentration ratio liver/blood close to 1 and a wide spread in the metastases/liver concentration ratios in the range 0.8-3.6, partially attributable to histological variations between samples. Based on the boron concentrations and dose considerations (liver < or =15 Gy-Eq and tumor> or =40 Gy-Eq) at the RA-3 thermal neutron facility (mean flux of about (6+/-1) x 10(9) n cm(-2)s(-1)), ex-situ treatment of liver metastases at RA-3 would be feasible.
Angel H. Roffo Institute of Oncolgy, San Martín 5481, (1417) C.A. Buenos Aires, Argentina.
J
J
Cardoso
S
S
Nievas
M
M
Pereira
A
A
Schwint
V
V
Trivillin
E
E
Pozzi
E
E
Heber
A
A
Monti Hughes
P
P
Sanchez
E
E
Bumaschny
M
M
Itoiz
S
S
Liberman
D000230:Adenocarcinoma / Q000378:metabolism* / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D000368:Aged; D001118:Argentina; D001895:Boron / Q000097:blood / Q000493:pharmacokinetics*; D001896:Boron Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007262:Infusions, Intravenous; D007554:Isotopes / Q000097:blood / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism* / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010649:Phenylalanine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D014018:Tissue Distribution; D014182:Transplantation, Autologous
D001896:Boron Compounds; D007554:Isotopes; D011838:Radiation-Sensitizing Agents; D010649:Phenylalanine; D001895:Boron; C033685:4-boronophenylalanine