Investigation of histopathologic changes in the ureter walls in vesicoureteral reflux.
OBJECTIVE
This study aimed to determine the histopathologic changes in ureteral walls (UWs) in children with vesicoureteral reflux (VUR).


METHODS
Twenty ureteral specimens taken from children were divided into 2 groups, refluxing (R) and control (C) groups, each containing 10 specimens. Wall thickness of the ureter, tunica muscularis of the ureter, mucosal thickness of the ureter (uroepithelium), collagen thickness of the ureter, mucosal change, and inflammation were evaluated in resected distal UWs in children with VUR.


RESULTS
The mean wall thickness of the ureter, mean tunica muscularis of the ureter, and mean uroepithelium values of the UWs in the R group were not significantly lower compared to those in the C group. Collagen thickness values in the R group were significantly lower than those in the C group.


CONCLUSIONS
Our data suggest that wall thickness (tunica muscularis and uroepithelium) was not significantly decreased, but collagen thickness of the ureter was decreased in the UWs of children with VUR.
Yurtçu
Müslim
M
Department of Pediatric Surgery, Meram Medical School of Selcuk University, Konya, Turkey. muslimyurtcu@hotmail.com
Gürbüzer
Nilifer
N
Findik
Siddika
S
Avunduk
Mustafa Cihat
MC
Günel
Engin
E
D000293:Adolescent; D000704:Analysis of Variance; D001707:Biopsy, Needle; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009130:Muscle, Smooth / Q000473:pathology; D011336:Probability; D012016:Reference Values; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014513:Ureter / Q000473:pathology* / Q000601:surgery; D013519:Urogenital Surgical Procedures / Q000379:methods; D014718:Vesico-Ureteral Reflux / Q000473:pathology* / Q000601:surgery*