Sperm chromatin anomalies have an adverse effect on the outcome of conventional in vitro fertilization: a study with strictly controlled external factors.
Conflicting conclusions present in earlier studies on the relationship between sperm chromatin anomalies and outcome of conventional in vitro fertilization (IVF) may result from confounding by poorly controlled external factors. We examined the relationship of sperm chromatin parameters and outcome of conventional IVF while strictly controlling external factors.
Department of Male Clinical Research, National Research Institute for Family Planning, Beijing, People's Republic of China; Graduate School of Peking Union Medical College, Beijing, People's Republic of China.
Long-Jie
LJ
Gu
Department of Male Clinical Research, National Research Institute for Family Planning, Beijing, People's Republic of China. Electronic address: bjchenzhenwen@163.com.
Zhen-Wen
ZW
Chen
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
Zi-Jiang
ZJ
Chen
Department of Male Clinical Research, National Research Institute for Family Planning, Beijing, People's Republic of China.
Jian-Feng
JF
Xu
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
Mei
M
Li
D000328:Adult; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism*; D015986:Confounding Factors, Epidemiologic; D004249:DNA Damage / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012307:Risk Factors; D055101:Semen Analysis / Q000379:methods; D013094:Spermatozoa / Q000378:metabolism*; D016896:Treatment Outcome
D002843:Chromatin