[Giant cell tumors of soft tissue arising in surgical scars].
Giant cell tumor of soft tissue (GCT-ST) is a rare primary soft tissue tumor with low malignant potential. It is clinically and pathologically similar to the giant cell tumor of the bone. Two cases of GCT-ST in surgical scars are reported. Both tumors were initially regarded as tumor relapses of a leiomyosarcoma of deep soft tissue and a dermal in situ squamous cell carcinoma, respectively. The development of GCT-ST in surgical scars has not been observed previously. These findings suggest chronic inflammation and tissue repair as etiological factors in the development of GCT-ST. The period of time between initial surgical intervention and the development of the GCT-ST seems to be unusually short for the development of a "true" second neoplasm, which may underline the sometimes diffuse border between reactive "pseudosarcomatous" and neoplastic fibro-histiocytic lesions.
Institut für Pathologie und Neuropathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Deutschland. florian.grabellus@uk-essen.de
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F
Grabellus
S-Y
SY
Sheu
B
B
Schmidt
F
F
von Winterfeld
B
B
Schoenfeld
G
G
Taeger
U
U
Hillen
K W
KW
Schmid
D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D002921:Cicatrix / Q000473:pathology*; D003937:Diagnosis, Differential; D005153:Facial Neoplasms / Q000473:pathology / Q000601:surgery; D005870:Giant Cell Tumors / Q000473:pathology* / Q000601:surgery; D006119:Groin / Q000473:pathology / Q000601:surgery; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000601:surgery; D010307:Parotid Neoplasms / Q000473:pathology / Q000556:secondary; D011183:Postoperative Complications / Q000473:pathology* / Q000601:surgery; D012086:Reoperation; D012501:Saphenous Vein / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000601:surgery; D019043:Vascular Neoplasms / Q000473:pathology / Q000601:surgery; D020246:Venous Thrombosis / Q000473:pathology / Q000601:surgery