A new synthesis of caged GABA compounds for studying GABAA receptors.
A short and convergent synthetic approach to new photoactivatable precursors of gamma-aminobutyric acid (GABA) is described. When photolyzed, the 'caged' GABA precursor efficiently releases GABA, as judged by depolarization measurements on the mammalian GABA(A) receptor.
Fan
Lijun
L
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853-1301, USA.
Lewis
Ryan W
RW
Hess
George P
GP
Ganem
Bruce
B
D002460:Cell Line; D004566:Electrodes; D004594:Electrophysiology; D058787:GABA-A Receptor Antagonists; D006801:Humans; D018377:Neurotransmitter Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D058787:GABA-A Receptor Antagonists; D018377:Neurotransmitter Agents; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid