Anti-coxsackie virus B3 norsesquiterpenoids from the roots of Phyllanthus emblica.
Three new norsesquiterpenoid glycosides, 4'-hydroxyphyllaemblicin B (1) and phyllaemblicins E (2) and F (3), were isolated from the roots of Phyllanthus emblica, together with three known compounds, phyllaemblic acid (4), phyllaemblicin B (5), and phyllaemblicin C (6). Of these, 3 is a new norsesquiterpenoid dimer. The structures of 1-3 were established by spectroscopic data information and by acidic hydrolysis. The isolated compounds, together with two other known analogues, phyllaemblic acid methyl ester (7) and phyllaemblicin A (8), were evaluated for their antiviral activity toward coxsackie virus B3 (CVB3) by an in vitro cytopathic effect inhibitory assay. Compounds 5-7 exhibited strong anti-CVB3 activity.
Liu
Qing
Q
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Wang
Ya-Feng
YF
Chen
Rong-Jie
RJ
Zhang
Mei-Ying
MY
Wang
Yi-Fei
YF
Yang
Chong-Ren
CR
Zhang
Ying-Jun
YJ
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029822:Enterovirus B, Human / Q000187:drug effects*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D029842:Phyllanthus emblica / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C550881:4'-hydroxyphyllaemblicin B; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D012717:Sesquiterpenes; C550883:phyllaemblicin E; C550882:phyllaemblicin F