Syndrome of inappropriate antidiuretic hormone secretion associated with acute myeloid leukemia with multilineage dysplasia.
A patient having acute myeloid leukemia (AML) with multilineage dysplasia, developed hyponatremia and showed all symptoms of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) through a mechanism similar to tumor lysis. Retrospective immunohistochemical analysis of blast cells was positive for antidiuretic hormone (ADH) protein. According to us, this is the first case report of SIADH in an AML patient with multilineage dysplasia, showing blast cells immunostained for ADH, which clearly demonstrated that the tumor cells produced ADH.
Department of Internal Medicine (I), Osaka Medical College, Takatsuki, Osaka 569-0801, Japan. in1304@poh.osaka-med.ac.jp
Shoko
S
Nakayama
Taiji
T
Yokote
Kichinosuke
K
Kobayashi
Yuji
Y
Hirata
Toshikazu
T
Akioka
Takuji
T
Miyoshi
Takayuki
T
Takubo
Motomu
M
Tsuji
Toshiaki
T
Hanafusa
D000369:Aged, 80 and over; D019070:Cell Lineage; D006801:Humans; D006965:Hyperplasia / Q000150:complications; D007177:Inappropriate ADH Syndrome / Q000150:complications*; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D022423:Myeloid Cells / Q000473:pathology*