Isolation of hypoglycemic phytoconstituent from Swietenia macrophylla seeds.
The present study was undertaken to isolate a novel antidiabetic molecule from Swietenia macrophylla seeds. The hydroalcohol extract of Swietenia macrophylla seeds was subjected for bioassay guided isolation employing glucose utilization assay by the isolated rat hemi-diaphragm method in vitro. One tetranortriterpenoid, swietenine, isolated from the chloroform fraction exhibited significant (p<0.01) activity and the effect was comparable to that of human insulin (p<0.01).
Maiti
Anup
A
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. anup_phytochem@yahoo.com
Dewanjee
Saikat
S
Sahu
Ranabir
R
D000818:Animals; D005947:Glucose / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D036701:Limonins / Q000302:isolation & purification* / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D012639:Seeds / Q000737:chemistry*
D007004:Hypoglycemic Agents; D007328:Insulin; D036701:Limonins; D010936:Plant Extracts; C546524:swietenine; D005947:Glucose