Inflammation, atherosclerosis, and arterial thrombosis: role of the scavenger receptor CD36.
The CD36 scavenger receptor recognizes oxidized low-density lipoprotein (LDL) and cell-derived microparticles. It is expressed on macrophages and platelets and is a mediator of both atherogenesis and thrombosis. Macrophages from CD36-null mice have a defect in foam cell formation in response to exposure to oxidized LDL, and CD36-null mice fed an atherogenic Western diet have significantly less atherosclerosis than their wild-type counterparts. On platelets, CD36 recognition of oxidized LDL contributes to their activation and provides a mechanistic link between hyperlipidemia, oxidant stress, and the prothrombotic state. Cell-derived microparticles are also major ligands for CD36 and contribute to thrombus formation in a CD36-dependent manner even in the absence of hyperlipidemia. CD36 deficiency in mice is associated with inhibition of thrombus formation and with a reduction in microparticle accumulation in thrombi. Targeting CD36 is a promising avenue for the treatment of atheroinflammatory disorders.
Department of Cell Biology, Cleveland Clinic, 9500 Euclid Avenue, NC10, Cleveland, OH 44195, USA. silverr2@ccf.org
Roy L
RL
Silverstein
D000818:Animals; D050197:Atherosclerosis / Q000209:etiology*; D018955:CD36 Antigens / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D051379:Mice; D013927:Thrombosis / Q000209:etiology*
D018955:CD36 Antigens