Prompt gamma neutron activation analysis of 10B and Gd in biological samples at the MEPhI reactor.
The purpose of the work was to build a prompt gamma neutron activation analysis (PGNAA) facility at the MEPhI reactor for analyzing the content of various elements for NCT. The facility was implemented on a monochromatic neutron beam. Methods of quantitative (10)B and Gd measurement have been developed for pharmacokinetic studies. The facility is capable of measuring 1 microg of (10)B and 10 microg of Gd in biological samples with an error less than 10%. The detection limit of the facility is 0.3 microg of (10)B and 2 microg of Gd. Neutron flux attenuation within biological tissue samples was estimated and a new system for determining the elemental concentration was suggested.
Khokhlov
V F
VF
Burnasyan Federal Medical Biophysical Center of the Federal Medical Agency, ul. Zivopisnaya 46, Moscow, Russia.
Zaitsev
K N
KN
Beliayev
V N
VN
Kulakov
V N
VN
Lipengolts
A A
AA
Portnov
A A
AA
D000818:Animals; D001895:Boron / Q000032:analysis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000706:statistics & numerical data; D005682:Gadolinium / Q000032:analysis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005720:Gamma Rays; D006801:Humans; D007554:Isotopes / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use; D051379:Mice; D009501:Neutron Activation Analysis / Q000295:instrumentation* / Q000706:statistics & numerical data; D017247:Neutron Capture Therapy / Q000706:statistics & numerical data; D009688:Nuclear Reactors; D012426:Russia; D014018:Tissue Distribution
D007554:Isotopes; D005682:Gadolinium; D001895:Boron