cAMP-mediated regulation of CYP enzymes and its application in chemotherapy.
Certain anti-cancer prodrugs are subject to cytochrome P450 (CYP)-mediated metabolism and become more active. Because CYP activity may be regulated by phosphorylation via adenylyl cyclase/protein kinase A, selective adenylyl cyclase subtype activators may be utilized in future chemotherapy to regulate CYP activity as a switch in a tumor tissue-specific manner.
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. yishikaw@med.yokohama-cu.ac.jp
Yoshihiro
Y
Ishikawa
Sayaka
S
Suzuki
Koji
K
Otsu
Coskun
C
Ulucan
Kousaku
K
Iwatsubo
Haruki
H
Eguchi
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000627:therapeutic use; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D020536:Enzyme Activators / Q000494:pharmacology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D010766:Phosphorylation; D011355:Prodrugs / Q000378:metabolism* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D020536:Enzyme Activators; D011355:Prodrugs; D003577:Cytochrome P-450 Enzyme System; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D000262:Adenylyl Cyclases