The effect of ethyl cyanoacrylate on experimental posterior lateral spinal fusion in a rat model.
OBJECTIVE
Cyanoacrylates (CAs) are a type of tissue adhesives which are currently the most commonly used for cutaneous closings. The use of CAs was reported in other clinical procedures such as odontology, neurological surgery, maxillary surgery, orthopaedics, plastic surgery, etc. In this experimental study the authors carried out posterolateral spinal fusion in a rat model to test the usefulness of ethyl-cyanoacrylate (ECA) in fixation of allograft/autograft fusions.


METHODS
25 Sprague-Dawley rats were randomized into two study groups. Bilateral posterolateral lumbar intertransverse process spinal fusion was performed with both autograft and allograft in both groups. ECA gel was dropped in the fusion area in a rat model in group II.


RESULTS
The fusion rates as determined by manual palpation were 75% in controls and 46% in the ECA group (p = 0.322). According to radiographic score, the spinal segment was considered to be fused radiographically in 66% of controls and in 46% of animals in the ECA group (p = 0.43). The mean histological scores were 5.58 +/- 0.14 and 4.53 +/- 0.18 for the control and treatment group, respectively (p = 0.001). The mean bone density of the fusion masses was 101.3 +/- 2.5 in the control group and 92.0 +/- 3.3 in the ECA treatment group (p = 0.044).


CONCLUSIONS
Ethyl-cyanoacrylate appeared to retard the osteogenic fusion but was well tolerated and did not induce necrosis, allergic reaction, infection, necrosis or neurological deficit in a rat model of posterolateral spinal fusion.
Gezici
Ali Riza
AR
Bes kavaklar Mahallesi, Oznur Apt. No: 16/8 14300-Bolu, Turkey. geziciar@gmail.com
Ergün
Rüçhan
R
Yilmaz
Fahri
F
Gürel
Kamil
K
D000269:Adhesives / Q000008:administration & dosage*; D000287:Administration, Topical; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004195:Disease Models, Animal; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D011859:Radiography; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013123:Spinal Fusion; D014945:Wound Healing / Q000187:drug effects
D000269:Adhesives; D003487:Cyanoacrylates; C029054:ethyl 2-cyanoacrylate