Can intrabodies targeted to the secretory compartment interact  with a cytosolic protein? A comment on the article by Sawahata  et al. "Cytoplasmic expression and specific binding of the VH/VL  single domain intrabodies in transfected NIH3T3 cells", Exp. Mol.  Pathol. 2008 Nov 27; Epub ahead of print.
Alessio
A
Cardinale
Silvia
S
Biocca
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D002451:Cell Compartmentation; D003600:Cytosol / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D007143:Immunoglobulin Heavy Chains / Q000276:immunology*; D007147:Immunoglobulin Light Chains / Q000276:immunology*; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D051379:Mice; D041681:NIH 3T3 Cells; D011485:Protein Binding; D014162:Transfection
D000906:Antibodies; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region