Compositional variations and anthelmentic activity of essential oils from rhizomes of different wild populations of Acorus calamus L. and its major component, beta-Asarone.
Hydro-distilled essential oils from Acorus calamus rhizomes collected from six different geographical zones in the northwest Himalayan region of Uttarakhand have been analyzed by GC and GC/MS. All the oils differed in their qualitative and quantitative make up, although beta-asarone was the major constituent of all of them. The essential oils and the isolated beta-asarone were screened for anthelmintic activity using contractility of Ascaridia galli. beta-Asarone, in particular, showed potent activity with IC50 values of 75.4 +/- 61.8 ng/mL.
Kumar
Ravendra
R
Department of Chemistry, College of Basic Sciences & Humanities, G. B. Pant University ofAgriculture & Technology, Pantnagar-263145, Uttarakhand, India.
Prakash
Om
O
Pan
Anil K
AK
Hore
Subrata K
SK
Chanotiya
Chandan S
CS
Mathela
Chandra S
CS
D029023:Acorus / Q000737:chemistry* / Q000145:classification; D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000737:chemistry* / Q000494:pharmacology*; D000871:Anthelmintics / Q000737:chemistry / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000871:Anthelmintics; D009822:Oils, Volatile; D010938:Plant Oils; C012195:asarone