[Jointed estrogenic activities of bisphenol A and three of its analogs].
The combined effect of environmental endocrine disruptors (EEDs) is one of the hottest topics. The estrogenic activities of BPA, BPAF, BPAP, BPF were tested based on recombinant gene yeast assay. Six mixtures were designed based on the result of the test,each of which had an equitoxic ratio ray (EC10 or EC50). The EC50 values are 6.81 x 10(-6) mol x L(-1), 7.44 x 10(-7) mol x L(-1), 1.43 x 10(-5) mol x L(-1), 7.52 x 10(-6) mol x L(-1) for BPA, BPAF, BPAP and BPF respectively,which reveals that the estrogenic activities order among the four bisphenols was BPAF> BPA> BPF> BPAP. The experiment shows that when BPA mixes with BPAF, BPAP and BPF in different ratios individually, different combination effects are produced. It reveals that the combined ratios of the components may affect the combined effect. The dose addition model and the independent action model are used to identify the combined effect. They are testified to be more intuitionistic and more comprehensive than other joint effect indices.
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China. njuzhanghc@163.com
Hong-chang
HC
Zhang
Liang-yan
LY
Chen
Shu-shen
SS
Liu
Da-qiang
DQ
Yin
D001559:Benzhydryl Compounds / Q000737:chemistry / Q000494:pharmacology*; D004347:Drug Interactions; D052244:Endocrine Disruptors / Q000494:pharmacology*; D004785:Environmental Pollutants / Q000737:chemistry / Q000494:pharmacology; D004852:Epoxy Compounds / Q000737:chemistry / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D000098826:Bisphenol A Compounds; D000098833:Bisphenol F Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D004852:Epoxy Compounds; D004967:Estrogens; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds; C008745:4,4'-bisphenol F; D000098833:Bisphenol F Compounds; C423722:bisphenol F diglycidyl ether