[Case-control studies on debridement combined with external application of Mangxiao for the treatment of severe open injuries of limbs].
OBJECTIVE
To investigate simple and convenient methods for the treatment of severe open injuries of limbs.


METHODS
From 2005.1 to 2008.3, 31 patients got limb salvage in 33 cases (Gustilo III B) from emergency, which were divided into two groups(A and B). The 16 patients in Group A (14 male and 2 female) were treated with emergency debridement, sequential dressing change, and finally with skin grafting or free flap. The 15 patients in Group B (11 male and 4 female) were treated with radical debridement (skin and muscle), decompression of fascial compartment routinely and repair of periosteal avulsion lesion. The patients in Group B were also treated with external application of Mangxiao postoperatively and dressing change for first time one week later. The clinical effects were assessed by the skin survival rate of degloving injury, the number of operative procedures (using free flap or not), the number of dressing changes in the first two weeks, body temperature and white cell count (48 h after the first debridement ). Statistical analysis was done with SPSS software. Chi-square analyses was used to compare the enumeration data, and compare means with independent samples T test for measurement data.


RESULTS
All the patients in Group A got limb salvage (10 patients were upper limb, 6 patients were lower limb), and the mean skin survival rate of degloving injury was (77.88 +/- 4.21)%. Five patients in Group A were finally treated with free flap. All the patients in Group B got limb salvage (10 patients were upper limb, 5 patients were lower limb) by a few secondary skin grafting, and the mean skin survival rate of degloving injury was (97.53 +/- 3.09)%. The mean skin survival rate of Group B was obviously better than that of Group A (P<0.01). The number of dressing changes in the first two weeks in Group B was absolutely less than that of Group A (P<0.01). Also, infection rate and the number of operative procedures of Group B was significantly less than that of Group A (P<0.01). All the patients were followed up for at least 3 months.


CONCLUSIONS
Radical debridement combined with external application of Mangxiao for the treatment of severe open fractures is simple, convenient and effective. It is better for a lot of people injured simultaneously in accident.
Department of Orthopaedics, Shuguang Hospital of Shanghai, Shanghai 200021, China. yuzhongxiang1@126.com
Zhong-xiang
ZX
Yu
Yong
Y
Kuang
Yi-wen
YW
Tan
Xin-feng
XF
Gu
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003646:Debridement / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005121:Extremities / Q000293:injuries*; D005260:Female; D005597:Fractures, Open / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016038:Skin Transplantation; D013524:Surgical Flaps
D004365:Drugs, Chinese Herbal