Fetal eyeball volume: relationship to gestational age and biparietal diameter.
OBJECTIVE
To measure and determine normal values of the fetal eyeball volume between 14 and 40 weeks of gestation.


METHODS
The volume of the fetal eyeball was measured with three-dimensional ultrasound between 14 and 40 weeks of gestation using the VOCAL software.Only singleton pregnancies without fetal growth restriction, diabetes mellitus, hypertension or major fetal malformation were included.


RESULTS
Over all, 203 women were studied. In 125 both eyeballs were measured while in 78 only one eyeball was measured. The volume of the eyeball correlated strongly with gestational age (right: R = 0.946, P < 0.001, n = 171. left: R = 0.945, P < 0.001, n = 156), and with the biparietal diameter (BPD) (right: R = 0.949, P < 0.001, n = 171. left: R = 0.953, P < 0.001, n = 156). Using regression analysis the best correlation between eyeball volume and the BPD were: square of right eyeball = -0.180 + 0.187 BPD, square of left eyeball = -0.182 + 0.187 BPD.


CONCLUSIONS
The volume of the eyeball has strong positive correlations with gestational age and BPD. Our data may be helpful in fetuses suspected of having eye anomalies.
Odeh
Marwan
M
Department of Obstetrics and Gynecology, Western Galilee Hospital, POB 21, Nahariya 22100, Israel. marwan20@bezeqint.net
Feldman
Yulia
Y
Degani
Shimon
S
Grinin
Vitali
V
Ophir
Ella
E
Bornstein
Jacob
J
D000328:Adult; D005123:Eye / Q000000981:diagnostic imaging / Q000196:embryology*; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D021621:Imaging, Three-Dimensional; D007231:Infant, Newborn; D011247:Pregnancy; D012016:Reference Values; D016216:Ultrasonography, Prenatal / Q000379:methods*; D055815:Young Adult