Lipid, inflammatory and haemorheological profiles are significantly affected by farmed fish eating: an intervention study.
OBJECTIVE
The objective of the present study was to evaluate the influence of short-term dietary intake of farmed fish on biomarkers related to the atherosclerotic process.


RESULTS
Lipid, inflammatory, and haemorheological variables before (T0) and after a dietary intervention with about 800 g Orbetello farmed sea bass per week for 10 weeks (T1) were evaluated in nine dyslipidemic subjects. Fish intake significantly decreased triacylglycerols (T1, 140.2+/-20.3 mg/dl versus T0, 183.3+/-29.2 mg/dl; P =0.04), whereas no significant changes for the other lipid variables have been observed. Moreover, dietary intervention significantly (P <0.05) decreased all of the inflammatory parameters investigated; namely, high-sensitivity C-reactive protein, interleukin-6, and interleukin-8. Furthermore, a significant (P =0.04) improvement in erythrocytes' deformability index was reported after 10 weeks of fish dietary intake (9.0+/-0.7% versus 5.4+/-1.0% for T1 and T0, respectively).


CONCLUSIONS
Dietary short-term intake of farmed fish seems to impose favourable biochemical changes in dyslipidemic subjects.
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, Florence, Italy. francescosofi@gmail.com
Francesco
F
Sofi
Anna Maria
AM
Gori
Francesca
F
Cesari
Rita
R
Paniccia
Lucia
L
Mannini
Gianluca
G
Giorgi
Giuliana
G
Parisi
Alessandro
A
Casini
Bianca Maria
BM
Poli
Gian Franco
GF
Gensini
Rosanna
R
Abbate
D000328:Adult; D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control; D001492:Bass; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D050171:Dyslipidemias / Q000097:blood* / Q000178:diet therapy*; D004907:Erythrocyte Deformability; D005260:Female; D005398:Fisheries; D018056:Hemorheology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007378:Interleukins / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017747:Seafood; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D018836:Inflammation Mediators; D007378:Interleukins; D008055:Lipids; D014280:Triglycerides; D002097:C-Reactive Protein