Comparative evaluation of Tc-99m cystine and Tc-99m MAG3 in normals and patients with renal functional impairment.
Tc-99m cystine has been proved to be a good renal agent in animals for morphologic as well as the functional status of the kidney. In this study, we compared Tc-99m cystine with Tc-99m mercaptoacetyltriglycine, which is used for evaluation of renal function in normal patients, and those with various degrees of renal functional impairment. The clearance values and static images are compared with Tc-99m mercaptoacetyltriglycine. The results show that Tc-99m cystine has good radiopharmaceutical characteristics suitable for evaluation of both renal function as well as morphology.
Nuclear Medicine Division, Indian Institute of Chemical Biology, Kolkata, West Bengal, India. mridulamisra@iicb.res.in
Mridula
M
Misra
Prasanta K
PK
Pradhan
Kakali
K
De
Susmita
S
Chandra
Birendra K
BK
Das
D000328:Adult; D003553:Cystine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology / Q000502:physiology* / Q000503:physiopathology*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D017263:Technetium Tc 99m Mertiatide / Q000493:pharmacokinetics*
D015609:Organotechnetium Compounds; C060718:technetium Tc 99m cystine; D017263:Technetium Tc 99m Mertiatide; D003553:Cystine