[Developmental control of organ growth by the Hippo pathway].
Our understanding of organ growth control during development has recently been given a boost by the discovery of the Hippo signalling pathway in Drosophila. This phosphorylation cascade is required for imaginal disc, the organ precursors, to stop growing at the end of larval life; indeed, mutations in the genes encoding the kinases of this pathway, or in their interactors, lead to organ overgrowth. The Hippo pathway acts in repressing the transcription of target genes promoting proliferation and survival. This pathway is thought to integrate many upstream signals, although this is only partially understood. Altogether, integration of these inputs enables a tight control of cell number within organs and hence of organ size. As this pathway is conserved in mammals, it offers new research opportunities to better understand and fight cancer.
Bardet
Pierre-Luc
PL
National Institute for Medical Research (MRC), The Ridgeway, NW7 1AA London, UK. Pierre-Luc.Bardet@curie.fr
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002455:Cell Division; D002470:Cell Survival; D004330:Drosophila / Q000235:genetics / Q000254:growth & development*; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D014158:Transcription, Genetic; D000099317:Hippo Kinases
D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases