Detection of plasmid-mediated KPC-producing Klebsiella pneumoniae in Ottawa, Canada: evidence of intrahospital transmission.
Klebsiella pneumoniae isolates from three patients admitted to the Ottawa Hospital, a 1,040-bed teaching hospital, were found to contain the plasmid-borne K. pneumoniae carbapenemase (KPC)-producing bla gene (bla(KPC)). There was evidence of person-to-person transmission for two patients. Screening of 186 clinical isolates revealed no additional bla(KPC)-containing isolates.
Division of Microbiology, Department of Pathology and Laboratory Medicine, the Ottawa Hospital, 501 Smyth Rd., Ottawa, ON, Canada K1H 8L6.
David
D
Goldfarb
Sarah-Beth
SB
Harvey
Kelsi
K
Jessamine
Peter
P
Jessamine
Baldwin
B
Toye
Marc
M
Desjardins
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D002170:Canada; D003428:Cross Infection / Q000382:microbiology / Q000635:transmission*; D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D005798:Genes, Bacterial; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology / Q000635:transmission*; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000302:isolation & purification*; D008297:Male; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae