Brief review of polymorphic drug-metabolizing enzymes in Japanese populations: development of a higher-throughput genotyping method and proposed applications.
Different functional alleles for each subtype of cytochrome P450 (CYPs), thiopurine S-methyltransferase (TPMT), glutathione S-transferase (GST) and sulfotransferase (SULT) enzymes, have been identified. In this review, the genetic polymorphisms of drug-metabolizing enzymes in the Japanese population and their effects on metabolic activity are described in detail.
Laboratory of Drug Metabolism & Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15-8 Shiomi-cho, Choshi-city, Chiba 288-0025, Japan. tkubota-tky@umin.net
Takahiro
T
Kubota
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007564:Japan; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011110:Polymorphism, Genetic; D015238:Sulfotransferases / Q000235:genetics / Q000378:metabolism
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D008780:Methyltransferases; C022745:thiopurine methyltransferase; D005982:Glutathione Transferase; D015238:Sulfotransferases