Evaluation of dementia rating scales in Parkinson's disease dementia.
Disease-specific assessments are not currently available for patients with Parkinson's disease dementia (PDD). This study evaluated the criterion-related validity and test-retest reliability of the Alzheimer's Disease Assessment scale cognitive subscale (ADAS-cog) in terms of sensitivity for differentiation between mild and moderate severity impairment in PDD. Six other dementia rating scales and cognitive tests were also examined. A total of 113 patients with PDD or Alzheimer disease were recruited into this 4-week, multicenter study, segregated into 2 severity groups based on Mini-Mental State Examination (MMSE) score. Mean ADAS-cog scores showed a statistically significant separation between mild and moderate severity patients in both dementias (P < .001). For the ADAS-cog, test-retest Spearman correlation coefficients were significant for each dementia type and severity. This study demonstrated the criterion-related validity and test-retest reliability for ADAS-cog in patients with PDD and strong correlations with MMSE. This supports the validity of previous results obtained with these measures in studies of patients with PDD.
Harvey
Philip D
PD
Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA. philipdharvey1@cs.com
Ferris
Steven H
SH
Cummings
Jeffrey L
JL
Wesnes
Keith A
KA
Hsu
Chuanchieh
C
Lane
Roger M
RM
Tekin
Sibel
S
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards; D010300:Parkinson Disease / Q000175:diagnosis* / Q000523:psychology*; D015203:Reproducibility of Results; D012720:Severity of Illness Index