The strategy for prevention of measles and rubella prevalence with measles-rubella (MR) vaccine in Japan.
To eliminate the indigenous measles and rubella virus by 2012 in Japan, the strategy fro prevention of measles and rubella prevalence with measles-rubella (MR) vaccine was proposed. Since the vast majority of 1-year old infants are susceptible to measles and rubella, the first MR vaccine, the first MR vaccine should be administered at 1-year old to sustain the herd immunity. Since significant elevation of measles and rubella antibody titers were eliminated in a half of children after the second dose, the second dose of of MR vaccine within 1 year before elementary school entry is the effective maneuver. Moreover, supplement MR vaccination to the teenage group and 20-29 years' group might be necessary, because the mean measles antibody titers in this group were significantly lower compared with those in the older individuals' groups.
Department of Pediatrics, National Hospital Organization Mie National Hospital, Mie, Japan. ihara@mie-m.hosp.go.jp
Toshiaki
T
Ihara
D006801:Humans; D007564:Japan / Q000453:epidemiology; D008457:Measles / Q000453:epidemiology / Q000517:prevention & control*; D008458:Measles Vaccine / Q000276:immunology; D015995:Prevalence; D012409:Rubella / Q000453:epidemiology / Q000517:prevention & control*; D012411:Rubella Vaccine / Q000276:immunology; D017778:Vaccines, Combined / Q000276:immunology
D008458:Measles Vaccine; D012411:Rubella Vaccine; D017778:Vaccines, Combined