Changes in prostate-specific antigen levels and prostate volume in octogenarian men: community-based study.
OBJECTIVE
To examine the change in prostate-specific antigen (PSA) levels and prostate volume (PV) in octogenarian men compared with those in septuagenarian men and evaluate the possibility of PSA as a surrogate marker for PV in octogenarian men.


METHODS
A total of 441 men were recruited from whom random and selected oldest-old samples (age >or=85 years) from the Korean Longitudinal Study on Health and Aging, which was a population-based, prospective cohort study on health, aging, and common geriatric diseases of Koreans >or=65 years old. Men in their 70s (n = 136, 70-79 years) and 80s (n = 125, 80-89 years) were included. The PV was measured by transrectal ultrasonography, and the PSA level was determined using immunoradioassay.


RESULTS
No significant differences were found in the serum PSA levels between the men in their 70s and 80s (P = .128). However, the 95th percentile of the serum PSA level was 5.23 and 6.60 ng/mL in those in their 70s and 80s, respectively. The men in their 80s had a greater total PV and transitional volume than did men in their 70s (P = .026 and P = .009, respectively). The PV and PSA level correlated with age (P = .034), and the increase in PV stratified by PSA was statistically significant (P < .0001).


CONCLUSIONS
Although the PV had increased steadily in octogenarian men, the serum PSA level of men in their 80s did not show a significant difference compared with men in their 70s. We suggest that PSA is a good surrogate marker for PV, even in octogenarian men.
Department of Urology, Pochon Cha University College of Medicine, Seongnam, Korea.
Jae Seung
JS
Chung
Seok-Soo
SS
Byun
Byung Kyu
BK
Han
Seong Jin
SJ
Jeong
Sung Kyu
SK
Hong
Sang Eun
SE
Lee
D000367:Age Factors; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*
D017430:Prostate-Specific Antigen