One-pot, direct incorporation of [11C]CO2 into carbamates.
Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of (11)CO(2) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of (11)C-labeled carbamates at 75 degrees C within 10 minutes in radiochemical yields above 70% (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.
Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. hooker@bnl.gov
Jacob M
JM
Hooker
Achim T
AT
Reibel
Sidney M
SM
Hill
Michael J
MJ
Schueller
Joanna S
JS
Fowler
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry*; D002250:Carbon Radioisotopes / Q000737:chemistry; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D019086:Bridged Bicyclo Compounds, Heterocyclic; D002219:Carbamates; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D002245:Carbon Dioxide; C031033:1,8-diazabicyclo(5.4.0)undec-7-ene