Severe respiratory symptoms to oxaliplatin infusion: a case report of delayed hypersensitivity reaction.
A 46-year-old man with adenocarcinoma of the sigmoid colon developed a hypersensitivity reaction after the sixth cycle of combination chemotherapy with oxaliplatin infusion. Hypersensitivity to oxaliplatin occurring, after several courses of therapy, in about 10-15% of patients, especially during or immediately after the oxaliplatin infusion. In this case report we present a delayed hypersensitivity reaction, consisting in dysesthesia and laryngeal spasm developed 10 h after the sixth administration of oxaliplatin.
Department of Experimental Medicine, Section of Pharmacology L. Donatelli, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy. simipot@hotmail.it
Simona
S
Potenza
Guglielmo
G
Nasti
Alessandro
A
Ottaiano
Ottaiano
O
Alessandro
Amelia
A
Filippelli
Francesco
F
Rossi
Annalisa
A
Capuano
D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000150:complications*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000077150:Oxaliplatin; D012140:Respiratory Tract Diseases / Q000139:chemically induced* / Q000150:complications*
D009944:Organoplatinum Compounds; D000077150:Oxaliplatin