Anti-heat shock protein 27 antibody levels and diabetes complications in the EURODIAB study.
OBJECTIVE
To assess whether serum anti-heat shock protein 27 (HSP27) antibody levels are associated with micro- and macrovascular complications of type 1 diabetes.


METHODS
Anti-HSP27 IgG antibody levels were measured in 531 type 1 diabetic subjects recruited as part of the cross-sectional analysis of the EURODIAB Prospective Complications Study. Case subjects (n = 363) were defined as individuals with one or more diabetes complications and control subjects (n = 168) as individuals with no evidence of any diabetes complication.


RESULTS
Anti-HSP27 levels were comparable in case and control subjects (19.6 arbitrary units/ml [11.3-32.7] vs. 20.4 arbitrary units/ml [11.7-35.3], geometric mean [interquartile range]), and there was no correlation between HSP27 and anti-HSP27 levels (r = 0.01, P = 0.81). In logistic regression analysis, anti-HSP27 was not associated with the presence of complications, even after adjustment for main risk factors.


CONCLUSIONS
Anti-HSP27 antibody levels are not a marker of vascular complications in type 1 diabetes.
Burt
Davina
D
Department of Internal Medicine, University of Turin, Turin, Italy. davina.burt@unito.it
Bruno
Graziella
G
Chaturvedi
Nish
N
Schalkwijk
Casper
C
Stehouwer
Coen D
CD
Witte
Daniel R
DR
Fuller
John H
JH
Pinach
Silvia
S
Perin
Paolo Cavallo
PC
Gruden
Gabriella
G
D000906:Antibodies / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D003925:Diabetic Angiopathies / Q000150:complications; D003930:Diabetic Retinopathy / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D055551:HSP27 Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D012016:Reference Values; D012044:Regression Analysis; D012307:Risk Factors
D000906:Antibodies; D055551:HSP27 Heat-Shock Proteins; D007074:Immunoglobulin G