Genetics of chronic obstructive pulmonary disease: a succinct review, future avenues and prospective clinical applications.
Chronic obstructive pulmonary disease (COPD) is influenced by genetic and environmental factors. A large number of candidate gene-association studies and genome-wide linkage scans have been conducted to elucidate the genetic architecture underlying this disease. The compilation of these studies clearly revealed the complex genetic nature of COPD. Multiple genes acting on specific environmental backgrounds are likely to be the tenet of this multifactorial disorder. Encouragingly, reproducible susceptibility genes, such as SERPINE2, were recently identified. Advances in genomic research offer unprecedented capabilities to interrogate the human genome and are likely to accelerate the discovery of new genes. A comprehensive catalogue of genes implicated in the pathogenesis of COPD has great potential to lead to the development of new therapies and explain interindividual response to treatment.
Institut universitaire de cardiologie et de pneumologie de Québec, Pavillon Margeritte-d'Youville, Y4190, 2725, Chemin Sainte-Foy, Quebec City, Quebec, G1V 4G5, Canada. yohan.bosse@crhl.ulaval.ca
Yohan
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Bossé
D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D015870:Gene Expression; D036281:Genetic Research; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D010597:Pharmacogenetics / Q000639:trends; D058255:Protease Nexins; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics; D058258:Serpin E2
D016564:Amyloid beta-Protein Precursor; D058255:Protease Nexins; D011956:Receptors, Cell Surface; C545486:SERPINE2 protein, human; D058258:Serpin E2