[The alterations in profiles of RAPD- and of ISSR-markers in progeny of the single gamma-irradiated mice of BALB/c strain].
Molecular-genetic effects in the offspring of BALB/c male mice exposed to single radiation doses of 1, 2 and 3 Gy were studied. Induced genetic variability was studied using such methods as assessment of variation RAPD- and ISSR-profiles. Comparative analysis of genetic radiosensitivity of stem spermatogonia and of spermatids is presented in the work. The frequency of changes in the patterns of the offsprings of irradiated mice was significantly different from the analogous parameters in the offsprings of the control group already at a dose of 1 Gy. Comparative analysis of genetic radiosensitivity at different stages of spermatogenesis revealed the similar sensitivity of spermatogonia and of spermatids at 1 and 3 Gy and a higer sensitivity of spematogonia at 2 Gy.
Miazin
A E
AE
Chumachenko
A G
AG
Pomerantseva
M D
MD
Ramaĭia
L K
LK
Shaĭkhaev
G O
GO
Rubanovich
A V
AV
D000818:Animals; D004247:DNA / Q000528:radiation effects; D005720:Gamma Rays / Q000009:adverse effects*; D005819:Genetic Markers / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018812:Paternal Exposure; D011110:Polymorphism, Genetic / Q000528:radiation effects*; D011836:Radiation Tolerance; D019105:Random Amplified Polymorphic DNA Technique; D012091:Repetitive Sequences, Nucleic Acid / Q000528:radiation effects; D012098:Reproduction / Q000235:genetics* / Q000528:radiation effects*; D013087:Spermatids / Q000528:radiation effects; D013093:Spermatogonia / Q000528:radiation effects
D005819:Genetic Markers; D004247:DNA