Motor complications in patients form the German Competence Network on Parkinson's disease and the DRD3 Ser9Gly polymorphism.
In addition to levodopa treatment and disease duration, genetic predisposition might contribute to the development of medication-related complications in Parkinson's disease (PD). As recent observations indicate the dopamine D(3) receptor (DRD3) to modulate both therapeutic action of levodopa and dyskinesia, we reappraised the impact of the DRD3 Ser9Gly polymorphism on development of motor complications in a large scale association study based on the gene bank of the German Competence Network on Parkinson's disease. Stepwise regression analysis revealed no effect of DRD3 Ser9Gly on chorea, dystonia, or motor fluctuations in PD, despite incorporating established clinical risk factors to avoid overlooking an effect of genotype. Duration of PD was confirmed as the most important clinical risk factor, followed by age of disease onset and female sex. Additional studies incorporating grading of motor complications, and combinations of risk genotypes, are warranted.
Department of Neurology, University of Bonn, Bonn, Germany. spaus@uni-bonn.de
Sebastian
S
Paus
Franziska
F
Gadow
Michael
M
Knapp
Christine
C
Klein
Thomas
T
Klockgether
Ullrich
U
Wüllner
D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects; D019058:Community Networks / Q000706:statistics & numerical data; D004409:Dyskinesia, Drug-Induced / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005858:Germany / Q000453:epidemiology; D005998:Glycine / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D012044:Regression Analysis; D012694:Serine / Q000235:genetics*
D014150:Antipsychotic Agents; C493593:DRD3 protein, human; D050637:Receptors, Dopamine D3; D012694:Serine; D005998:Glycine