Decorin regulates endothelial cell-matrix interactions during angiogenesis.
Interactions between endothelial cells and the surrounding extracellular matrix are continuously adapted during angiogenesis, from early sprouting through to lumen formation and vessel maturation. Regulated control of these interactions is crucial to sustain normal responses in this rapidly changing environment, and dysfunctional endothelial cell behaviour results in angiogenic disorders. The proteoglycan decorin, an extracellular matrix component, is upregulated during angiogenesis. While it was shown previously that the absence of decorin leads to dysregulated angiogenesis in vivo, the molecular mechanisms were not clear. These abnormal endothelial cell responses have been attributed to indirect effects of decorin; however, our recent data provides evidence that decorin directly regulates endothelial cell-matrix interactions. This data will be discussed in conjunction with findings from previous studies, to better understand the role of this proteoglycan in angiogenesis.
Fiedler
Lorna R
LR
Clinical Pharmacology, Rayne Institute, University College London, London, UK. l.fiedler@ucl.ac.uk
Eble
Johannes A
JA
D000818:Animals; D002417:Cattle; D002450:Cell Communication; D021982:Cell-Matrix Junctions / Q000378:metabolism*; D058575:Decorin; D042783:Endothelial Cells / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D011485:Protein Binding; D011509:Proteoglycans / Q000378:metabolism*; D015398:Signal Transduction
C546878:DCN protein, human; C546879:Dcn protein, mouse; D058575:Decorin; D016326:Extracellular Matrix Proteins; D016023:Integrins; D011509:Proteoglycans