Photinides A-F, cytotoxic benzofuranone-derived gamma-lactones from the plant endophytic fungus Pestalotiopsis photiniae.
Photinides A-F (1-6), six new unique benzofuranone-derived gamma-lactones, have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis photiniae. The structures of these compounds were elucidated primarily by NMR spectroscopy, and their absolute configurations were assigned by application of the CD excitation chirality method. Compounds 1-6 displayed modest cytotoxic effects against the human tumor cell line MDA-MB-231.
Ding
Gang
G
Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
Zheng
Zhihui
Z
Liu
Shuchun
S
Zhang
Hua
H
Guo
Liangdong
L
Che
Yongsheng
Y
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010944:Plants / Q000382:microbiology; D013237:Stereoisomerism; D013098:Xylariales / Q000737:chemistry*
D000970:Antineoplastic Agents; D001572:Benzofurans; D007783:Lactones