Persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis.
This study was designed to investigate persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis. Milk samples were collected at a 1-d interval after the last administration from 34 individual cows that had received intramammary infusions of gentamicin. The doses and treatment times evaluated in this study represented those that have been applied by veterinarians in practice. The tetrazolium chloride assay was used to determine whether there were significant residues of the antibiotic in the samples. Persistence of detectable drug residues in milk from 33 cows (28 cows, <or=6 infusions at <or=0.7 g gentamicin; and 5 cows, 2 infusions at 0.8 g gentamicin) did not exceed 5 d; but 1 cow (5 infusions at 0.8 g gentamicin) had detectable residues in its milk for 9 d. Our results suggest that a 5-d milk withdrawal period might be insufficient to secure the clearance of the contamination of gentamicin, because treatment times and dosages contribute to the antibiotic clearance. A larger scale of samples are needed for further investigations.
Department of Veterinary Medicine, Zhejiang University, Hangzhou 310029, China.
Xun
X
Tan
Ye-wen
YW
Jiang
Yi-jun
YJ
Huang
Song-hua
SH
Hu
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000032:analysis* / Q000627:therapeutic use*; D007774:Lactation / Q000378:metabolism*; D008413:Mastitis / Q000188:drug therapy* / Q000378:metabolism / Q000662:veterinary*; D008892:Milk / Q000737:chemistry*; D013552:Swine
D000900:Anti-Bacterial Agents; D005839:Gentamicins