Emerging concepts in the pathogenesis of epilepsy and epileptogenesis.
Recent studies of the problem of ictogenesis, or the ways that seizures develop in an already hyperexcitable brain, are leading to paradigm-shifting concepts that may lead to exciting new therapies for seizures. Research on the equally important area of epileptogenesis, or the ways that a normal brain becomes epileptic, is also expanding, but comparable research into translation of laboratory findings into successful clinical interventions for those at high risk needs to be developed.
Dichter
Marc A
MA
Department of Neurology, University of Pennsylvania, 3 Gates Building, 3400 Spruce St, Philadelphia, PA 19104-4204, USA. dichter@mail.med.upenn.edu
D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D001925:Brain Damage, Chronic / Q000503:physiopathology; D004569:Electroencephalography / Q000187:drug effects; D004828:Epilepsies, Partial / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D019579:Neocortex / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D009433:Neural Inhibition / Q000502:physiology; D012307:Risk Factors; D012598:Sclerosis
D000927:Anticonvulsants