The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects.
A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). As replication in several studies is mandatory to confirm genetic results, we analyzed the T-381C polymorphism in seven independent case-control cohorts and in 291 T2D-enriched pedigrees totalling 39 557 subjects of European origin. A meta-analysis of the seven case-control studies (n = 39 040) showed a nominal protective effect [odds ratio (OR) = 0.86 (0.79-0.94), P = 0.0006] of the CC genotype on T2D risk, consistent with the previous study. By combining all available data (n = 49 279), we further confirmed a modest contribution of the BNP T-381C polymorphism for protection against T2D [OR = 0.86 (0.80-0.92), P = 1.4 x 10(-5)]. Potential confounders such as gender, age, obesity status or family history were tested in 4335 T2D and 4179 normoglycemic subjects and they had no influence on T2D risk. This study provides further evidence of a modest contribution of the BNP T-381C polymorphism in protection against T2D and illustrates the difficulty of unambiguously proving modest-sized associations even with large sample sizes.
CNRS-8090-Institute of Biology, Pasteur Institute, Lille, France.
Hélène
H
Choquet
Christine
C
Cavalcanti-Proença
Cécile
C
Lecoeur
Christian
C
Dina
Stéphane
S
Cauchi
Martine
M
Vaxillaire
Samy
S
Hadjadj
Fritz
F
Horber
Natasha
N
Potoczna
Guillaume
G
Charpentier
Juan
J
Ruiz
Serge
S
Hercberg
Suliya
S
Maimaitiming
Ronan
R
Roussel
Michael
M
Boenhnke
Anne U
AU
Jackson
Wolfgang
W
Patsch
Franz
F
Krempler
Benjamin F
BF
Voight
David
D
Altshuler
Leif
L
Groop
Gudmar
G
Thorleifsson
Valgerdur
V
Steinthorsdottir
Kari
K
Stefansson
Beverley
B
Balkau
Philippe
P
Froguel
David
D
Meyre
D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D005060:Europe / Q000453:epidemiology; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000235:genetics* / Q000378:metabolism; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
D020097:Natriuretic Peptide, Brain