Reimplantation of the resected tumour-bearing segment after recycling using liquid nitrogen for osteosarcoma.
Reconstruction after en block resection of malignant tumours is still the subject of debate. We questioned the effectiveness of reconstruction by reimplanting the tumour-bearing segment after recycling in liquid nitrogen. Ten patients with osteosarcoma around the knee were included, with a mean age of 21 years. The operative technique included wide en bloc excision, debridement, and management of the resected segment with liquid nitrogen followed by reimplantation and internal fixation. At a mean follow-up of 4.5 years there was no local or systemic recurrence and the mean functional score was 82.4%. The frozen graft united proximally and distally in all but one patient in a period ranging from six to ten months. The effectiveness of this reconstruction technique in properly selected patients with osteosarcoma is comparable to other techniques of biological reconstruction with the added benefit of being simple, cheap and durable.
Orthopaedic Surgery Department, Demerdash Hospital, Ain Shams University, Abbasseia Square, Cairo, Egypt. melniny2000@yahoo.com
Mohamed
M
Abdel Rahman
Ayman
A
Bassiony
Hisham
H
Shalaby
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D005260:Female; D005269:Femur / Q000473:pathology / Q000601:surgery; D017048:Health Care Costs; D006801:Humans; D007720:Knee Prosthesis; D023821:Limb Salvage / Q000191:economics / Q000379:methods*; D008297:Male; D009364:Neoplasm Recurrence, Local; D009584:Nitrogen / Q000494:pharmacology*; D016348:Osseointegration; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D011859:Radiography; D020127:Recovery of Function; D012092:Replantation; D013977:Tibia / Q000473:pathology / Q000601:surgery; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult
D009584:Nitrogen