Iron trafficking as an antimicrobial target.
Iron is essential for the survival of most organisms. Microbial iron acquisition depends on multiple, sometimes complex steps, many of which are not shared by higher eukaryotes. Depriving pathogenic microbes of iron is therefore a potential antimicrobial strategy. The following minireview briefly describes general elements in microbial iron uptake pathways and summarizes some of the current work aiming at their medicinal inhibition.
Frederick
Rosanne E
RE
Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA.
Mayfield
Jeffery A
JA
DuBois
Jennifer L
JL
D000890:Anti-Infective Agents / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D007501:Iron / Q000378:metabolism*; D015394:Molecular Structure; D017262:Siderophores / Q000378:metabolism / Q000502:physiology
D000890:Anti-Infective Agents; D017262:Siderophores; D007501:Iron