A Nurr1 pathway for neuroprotection.
Mutations in the gene encoding the orphan nuclear receptor Nurr1 are linked to a rare familial form of Parkinson's disease. By examining the function of its mouse homolog, Saijo et al. (2009) provide evidence that Nurr1 protects dopaminergic neurons by suppressing inflammatory gene expression in astrocytes and microglia.
Institute for Molecular Medicine, University of California, Los Angeles, CA 90095, USA.
Steven J
SJ
Bensinger
Peter
P
Tontonoz
D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D051379:Mice; D017628:Microglia / Q000378:metabolism; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D010300:Parkinson Disease / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; C539883:Nr4a2 protein, mouse; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D014157:Transcription Factors