The treatment of varicella-zoster virus infection and its complications.
BACKGROUND
Varicella, zoster and their complications remain important causes of morbidity and mortality in a population containing increasing numbers of elderly or immunocompromised individuals.


OBJECTIVE
To review varicella-zoster virus pathogenesis and current therapeutic options.


METHODS
The English-language literature related to varicella-zoster virus, its associated diseases, complications and treatments was identified using the Pubmed search engine, examination of reference lists of reviewed articles and the authors' personal knowledge. Focus was placed on those studies and meta-analyses performed within the past 5 years.


CONCLUSIONS
Antiviral agents may be used to prevent or treat the complications of varicella or zoster in a variety of patient groups. The oral prodrugs valaciclovir and famciclovir have an expanding role in the management of disease. A stepwise approach to the management of post-herpetic neuralgia should be employed in affected patients with tricyclic antidepressants and alpha2delta ligands as first-line agents.
Department of Infectious Diseases, Royal Hallamshire Hospital, Sheffield, UK. david.partridge@sth.nhs.uk
David G
DG
Partridge
Michael W
MW
McKendrick
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006562:Herpes Zoster / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D014645:Herpesvirus 3, Human / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D011355:Prodrugs / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome
D000998:Antiviral Agents; D011355:Prodrugs