Reaching out for the other end with p53-binding protein 1.
Correct joining of broken chromosomes is indispensable to prevent cell death, ageing and cancer. Two recent papers highlight the importance of p53-binding protein 1 (53BP1) in connecting distant sites in T-cell receptor loci and dysfunctional telomeres. These studies refine our understanding of the specific subset of DNA double-strand breaks that require the accessory end-joining factor 53BP1.
van Gent
Dik C
DC
Department of Cell Biology and Genetics, Erasmus MC Rotterdam, The Netherlands. d.vangent@erasmusmc.nl
D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone; D002875:Chromosomes / Q000235:genetics / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism / Q000502:physiology*; D008957:Models, Genetic; D000071857:Tumor Suppressor p53-Binding Protein 1
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; C498301:TP53BP1 protein, human; C498302:Trp53bp1 protein, mouse; D000071857:Tumor Suppressor p53-Binding Protein 1