Symbiospirols: novel long carbon-chain compounds isolated from symbiotic marine dinoflagellate Symbiodinium sp.
Symbiospirols A, B, and C, long carbon-chain compounds with a molecular weight of 1207 were isolated from the cultured symbiotic dinoflagellate Symbiodinium sp. Their planar structures and partial relative stereochemistries were elucidated based on 1D and 2D NMR spectra and a degradation reaction. Symbiospirols consisted of a C67-linear chain with a beta,beta'-dihydroxyl ketone moiety, eight hydroxyl groups, one tetrahydropyran ring, and two 1,6-dioxaspiro[4,4]nonane rings. Symbiospirol A had an inhibitory effect against l-phosphatidylserine-induced PKC activation.
Tsunematsu
Yuta
Y
Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan.
Ohno
Osamu
O
Konishi
Kaori
K
Yamada
Kaoru
K
Suganuma
Masami
M
Uemura
Daisuke
D
D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry*; D007249:Inflammation / Q000188:drug therapy; D008386:Marine Biology; D015394:Molecular Structure; D011493:Protein Kinase C / Q000187:drug effects; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D013141:Spiro Compounds; C541172:symbiospirol A; C541173:symbiospirol B; C541174:symbiospirol C; D011493:Protein Kinase C