Impact of polycystic ovary syndrome on selected indicators of in vitro fertilization and intracytoplasmic sperm injection treatment success.
OBJECTIVE
To examine the effect of polycystic ovary syndrome (PCOS), a marker of the metabolic syndrome, on selected indicators of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment success.


METHODS
A retrospective cohort study was conducted using existing data on 69 IVF/ICSI treatment cycles undergone by PCOS women and a caliper-matched sample of 69 IVF/ICSI treatment cycles undergone by non-PCOS women over a 7-year period at a major fertility treatment center. Matching criteria were age and date at IVF/ICSI treatment initiation. Process and outcome measures were used to define successful IVF/ICSI treatment. Statistical significance was determined at an alpha level of 0.05.


RESULTS
The total number of oocytes and the number of immature oocytes retrieved in the process of an IVF/ICSI cycle were significantly higher in the context of PCOS. No significant differences were observed among PCOS and non-PCOS groups on various IVF/ICSI cycle outcomes, including high-grade embryo, pregnancy achievement, miscarriage, and live birth status.


CONCLUSIONS
Although IVF/ICSI yields more oocytes in the context of PCOS, IVF/ICSI outcomes do not differ significantly by PCOS status. Prospective cohort studies are needed to examine short-term and long-term health effects of PCOS in the context of IVF/ICSI.
Beydoun
Hind A
HA
Graduate Program in Public Health, Eastern Virginia Medical School, 1123 Lewis Hall, 700 W. Olney Road, Norfolk, VA 23501-1980, USA. baydouha@evms.edu
Stadtmauer
Laurel
L
Zhao
Yueqin
Y
Russell
Helena
H
Matson
David O
DO
Oehninger
Sergio
S
D000328:Adult; D015331:Cohort Studies; D015897:Comorbidity; D004624:Embryo Transfer / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology* / Q000628:therapy; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology* / Q000628:therapy; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data*; D016387:Women's Health; D055815:Young Adult