Neuroinflammation and neuroprotective strategies in acute ischaemic stroke - from bench to bedside.
Cerebrovascular disease is one of the commonest causes of disability and mortality worldwide. Over the past two decades, a tremendous amount of research has been undertaken into developing effective therapeutic strategies for the treatment of acute stroke. Unfortunately, many neuroprotective agents that have shown successful results in treating animal models of acute stroke have failed to translate into clinical treatments. Only tissue-plasminogen activator (t-PA) is currently licensed for use in the treatment of acute ischaemic stroke. One of the important pathophysiological mechanisms involved during the acute phase of stroke is neuroinflammation. This review article will discuss the molecular aspects of neuroinflammation in acute ischaemic stroke and potential therapeutic strategies as part of translational medicine research.
Shah
Imtiaz M
IM
Department of Medicine for the Elderly, Mansionhouse Unit, Victoria Infirmary, Glasgow, Scotland, G41 3DX, UK. I.M.Shah@clinmed.gla.ac.uk
Macrae
I Mhairi
IM
Di Napoli
Mario
M
D000818:Animals; D015815:Cell Adhesion Molecules / Q000276:immunology; D018925:Chemokines / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D015870:Gene Expression; D006360:Heat-Shock Proteins; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology*; D020782:Matrix Metalloproteinases / Q000276:immunology; D018696:Neuroprotective Agents / Q000627:therapeutic use; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress; D020521:Stroke / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines; D006360:Heat-Shock Proteins; D018696:Neuroprotective Agents; D003165:Complement System Proteins; D019001:Nitric Oxide Synthase; D010959:Tissue Plasminogen Activator; D020782:Matrix Metalloproteinases