Animal models of neurodegenerative diseases.
Animal models of neurodegenerative disease are excellent tools for studying pathogenesis and therapies including cellular transplantation. In this chapter, we describe different models of Huntington's disease and Parkinson's disease, stereotactic surgery (used in creation of lesion models and transplantation) and finally transplantation studies in these models.
Phillips
Wendy
W
Cambridge Centre for Brain Repair, ED. Adrian Building, Cambridge, UK.
Michell
Andrew
A
Pruess
Harald
H
Barker
Roger A
RA
D000818:Animals; D017173:Caenorhabditis elegans; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D004195:Disease Models, Animal; D004330:Drosophila; D006801:Humans; D006816:Huntington Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D051379:Mice; D008822:Mice, Transgenic; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D033581:Stem Cell Transplantation / Q000379:methods*; D015027:Zebrafish; D051844:alpha-Synuclein / Q000235:genetics / Q000378:metabolism
D051844:alpha-Synuclein