Laparoscopy versus laparotomy for benign ovarian tumour.
BACKGROUND
Over the last 10 years laparoscopy and minilaparotomy have become increasingly common approaches for the surgical removal of benign ovarian tumours. However, in the event that a tumour is found to be malignant, laparotomy is the appropriate procedure. Careful preoperative assessment including transvaginal ultrasound with morphological scoring, colour doppler assessment of vascular quality, and serum cancer antigen 125 (CA 125) level is desirable.


OBJECTIVE
To determine the benefits, harms, and cost of laparoscopy or minilaparotomy compared with laparotomy in women with benign ovarian tumours.


METHODS
We searched electronic databases, trial registers, and reference lists of published trial reports. Reference lists from trials and review articles were searched.


METHODS
All randomised controlled trials comparing either laparoscopy or minilaparotomy with laparotomy for benign ovarian tumours.


METHODS
Eight review authors independently assessed the eligibility and quality of each study and extracted the data.


RESULTS
The results of nine randomised controlled trials (N = 482 women) showed that laparoscopic surgery was associated with fewer adverse events of surgery (surgical injury or postoperative complications including fever or infection) (OR 0.3, 95% CI 0.2 to 0.5), less postoperative pain (VAS score WMD -2.4, 95% CI -2.7 to -2.0), greater likelihood of being pain free after two days (OR 7.42, 95% CI 4.86 to 11.33), and fewer days in hospital (WMD -2.88, 95% CI -3.1 to -2.7) than with laparotomy.In one study that reported costs, laparoscopy was associated with a significant reduction in costs compared to laparotomy (WMD - USD 1045, 95% CI -1348 to -742) in 1993. Very high levels of heterogeneity made it inappropriate to pool data on duration of surgery.Three RCTs compared laparoscopy versus minilaparotomy and found that laparoscopy was associated with reduced odds of any adverse event (surgical injury or postoperative complications) (OR 0.10, 95% CI 0 to 0.8) and lower VAS scores for pain (WMD -1.0, 95% CI -1.6 to -0.45). Duration of hospital stay ranged between 1 and 2.2 days, with substantial heterogeneity.


CONCLUSIONS
In women undergoing surgery for benign ovarian tumours, laparoscopy was associated with a reduction in fever, urinary tract infection, postoperative complications, postoperative pain, number of days in hospital, and total cost. These findings should be interpreted with caution since only a small number of studies were identified. These included a total of only 769 women and not all of the important outcomes were reported in each study.
Social Medicine/Epidemiology, Federal University of Rio Grande do Sul, Jose de Alencar 1244, 1009 Menino Deus, Porto Alegre, Rio Grande do Sul, Brazil, 90880-480. lidia.rosi@terra.com.br
Lídia R F
LR
Medeiros
Daniela D
DD
Rosa
Mary C
MC
Bozzetti
Jandyra M G
JM
Fachel
Sue
S
Furness
Ray
R
Garry
Maria Ines
MI
Rosa
Airton T
AT
Stein
D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000191:economics; D007813:Laparotomy / Q000009:adverse effects / Q000191:economics; D010051:Ovarian Neoplasms / Q000601:surgery*; D016032:Randomized Controlled Trials as Topic