Phosphoramidite accelerated copper(i)-catalyzed [3 + 2] cycloadditions of azides and alkynes.
Monodentate phosphoramidite ligands are used to accelerate the copper(i)-catalyzed 1,3-dipolar cycloaddition of azides and alkynes (CuAAC) rapidly yielding a wide variety of functionalized 1,4-disubstituted-1,2,3-triazoles; Cu(i) and Cu(ii) salts both function as the copper source in aqueous solution to provide excellent yields.
Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
Lachlan S
LS
Campbell-Verduyn
Leila
L
Mirfeizi
Rudi A
RA
Dierckx
Philip H
PH
Elsinga
Ben L
BL
Feringa
D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D010756:Phosphoric Acids / Q000737:chemistry*
D000480:Alkynes; D000577:Amides; D001386:Azides; D010756:Phosphoric Acids; D003300:Copper; C011067:phosphoramidic acid