Significant increase in the apparent incidence of essential thrombocythemia related to new WHO diagnostic criteria: a population-based study.
To observe the effect of the new World Health Organization (WHO) criteria on the incidence of myeloproliferative neoplasms, we performed a retrospective study of a population-based registry in the Côte d'Or area, France, from 1980 to 2007. A total of 524 myeloproliferative neoplasms were registered for the 1980-2007 period, including 135 polycythemia vera, 308 essential thrombocythemia and 81 idiopathic myelofibroses. No change in the incidence of either polycythemia vera or idiopathic myelofibrosis was observed for the 2005-2007 period, compared to 1980-2004. On the contrary, a pronounced increase in the incidence of essential thrombocythemia was noted after 2005, mainly due to the use of JAK2 mutation screening and a lower threshold of platelet count. Our study confirms the relevance of the new WHO diagnostic criteria in allowing earlier diagnosis of essential thrombocythemia.
Laboratoire d'Hématologie, Hôpital du Bocage, CHU de Dijon, Dijon, France. francois.girodon@chu-dijon.fr
François
F
Girodon
Gilles
G
Bonicelli
Céline
C
Schaeffer
Morgane
M
Mounier
Serge
S
Carillo
Ingrid
I
Lafon
Paule Marie
PM
Carli
Inès
I
Janoray
Emmanuelle
E
Ferrant
Marc
M
Maynadié
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000175:diagnosis* / Q000453:epidemiology; D012042:Registries / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D013920:Thrombocythemia, Essential / Q000175:diagnosis* / Q000453:epidemiology; D014944:World Health Organization; D055815:Young Adult