Re-expression of locomotor function after partial spinal cord injury.
After a complete spinal section, quadruped mammals (cats, rats, and mice) can generally regain hindlimb locomotion on a treadmill because the spinal cord below the lesion can express locomotion through a neural circuitry termed the central pattern generator (CPG). In this review, we propose that the spinal CPG also plays a crucial role in the locomotor recovery after incomplete spinal cord injury.
Rossignol
S
S
Department of Physiology, Groupe de Recherche sur le Système Nerveux Central, Faculty of Medicine, Université de Montréal, Montreal, Canada. serge.rossignol@umontreal.ca
Barrière
G
G
Alluin
O
O
Frigon
A
A
D000222:Adaptation, Physiological; D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D006801:Humans; D007323:Instinct; D008124:Locomotion / Q000502:physiology*; D051379:Mice; D009416:Nerve Regeneration / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D013119:Spinal Cord Injuries / Q000503:physiopathology*