Approach and safety of comprehensive central compartment dissection in patients with recurrent papillary thyroid carcinoma.
BACKGROUND
Despite the generally favorable prognosis of patients with papillary thyroid cancers, 10-year recurrence rates for patients with stage I to III disease is greater than 20%, with central compartment recurrences common among these recurrent sites.


METHODS
This study is a retrospective analysis of consecutive patients treated by a single surgeon over an 18-month period of time terminating in 2003.


RESULTS
Sixty-three patients underwent a comprehensive dissection of levels VI and VII for papillary thyroid carcinoma during this period. There was a female predominance of 2:1, with 48% of patients being greater than 45 years of age. The median number of lymph nodes identified was 16 (range, 3-52), with 7 (1-20) lymph nodes pathologically involved. Permanent hypoparathyroidism was present on presentation in 13% of patients and developed in an additional 5% following surgery. Although recurrent laryngeal paralysis was present on presentation among 8 (13%) of patients, no patients experienced paralysis of documented functioning recurrent laryngeal nerves or necessitated tracheotomy. Postoperative thyroglobulin levels were reduced to nondetectable in 71% of the informative cases. Over 60% of patients were discharged on their first postoperative day.


CONCLUSIONS
Bilateral paratracheal and superior mediastinal dissection is an oncologically safe procedure exhibiting minimal morbidity when performed among experienced individuals despite multiple prior surgical procedures or existing vocal cord paralysis.
Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. gclayman@mdanderson.org
Gary L
GL
Clayman
Thomas D
TD
Shellenberger
Lawrence E
LE
Ginsberg
Beth S
BS
Edeiken
Adel K
AK
El-Naggar
Rena V
RV
Sellin
Steven G
SG
Waguespack
Dianna B
DB
Roberts
Anupam
A
Mishra
Steven I
SI
Sherman
D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery*; D055815:Young Adult