Ciclesonide therapy in asthma: a potential effect on small airway inflammation?
BACKGROUND
In asthma small airways inflammation often persists despite inhaled corticosteroids therapy.


OBJECTIVE
To discuss the effects of ciclesonide, a newer inhaled corticosteroid on small airways inflammation and the reliability of some biomarkers of small airways inflammation in asthma.


RESULTS
Evaluation of a study assessing the short-term effects of ciclesonide on small airways inflammation in patients with mild to moderate asthma.


CONCLUSIONS
Ciclesonide could have beneficial effects on small airways inflammation and some of the outcome measures used as efficacy endpoints could represent possible biomarkers of small airways involvement in obstructive chronic respiratory diseases.
Antoniu
Sabina Antonela
SA
Division of Pulmonary Disease, University of Medicine and Pharmacy, Pulmonary Disease University Hospital, Iasi, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro
Monica Pop
Carmen
C
D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D018836:Inflammation Mediators / Q000627:therapeutic use*; D010865:Pilot Projects; D011282:Pregnenediones / Q000627:therapeutic use*; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000473:pathology
D018927:Anti-Asthmatic Agents; D018836:Inflammation Mediators; D011282:Pregnenediones; C120481:ciclesonide