Synthesis of isoxazolo[5,4-b]pyridines by microwave-assisted multi-component reactions in water.
A series of new polycyclic-fused isoxazolo[5,4-b]pyridines were obtained by a one-pot tandem reaction under microwave irradiation in water. Without any use of additional reagent or catalyst, the synthetic protocol represents a green one and makes this methodology suitable for library synthesis in drug discovery efforts.
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou, Jiangsu 221116, PR China. laotu2001@263.net
Shu-Jiang
SJ
Tu
Xiao-Hong
XH
Zhang
Zheng-Guo
ZG
Han
Xu-Dong
XD
Cao
Shan-Shan
SS
Wu
Shu
S
Yan
Wen-Juan
WJ
Hao
Ge
G
Zhang
Ning
N
Ma
D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry
D007555:Isoxazoles; D011725:Pyridines; D054852:Small Molecule Libraries; D014867:Water