Effect of Dai-kenchu-to on gastrointestinal motility and gastric emptying.
OBJECTIVE
The gastrointestinal symptoms accompanying dysfunction of the remnant stomach were seen after pylorus-preserving operation. Against such complications, Dai-kenchu-to (DKT) is used, but scientific evidences for efficacy are poor. The effect of DKT on gastrointestinal motility and gastric emptying after pylorus-preserving operation was investigated.


METHODS
Using beagle dogs, the experimental models mimicking the state after pylorus-preserving pancreaticoduodenectomy were prepared. We sutured strain gauge transducers to the stomach, duodenum and jejunum and inserted indwelling tubes into the stomach. About 4 weeks after operation, DKT 0.1g/kg was administered during the fasting or fed state. At the same time, the gastric emptying was evaluated by the acetoaminophene method.


RESULTS
In the fasting state, administration of DKT enhanced the gastrointestinal motility and accelerated gastric emptying. In the postprandial state, no apparent effect on motility was seen.


CONCLUSIONS
DKT enhances the gastrointestinal motility after pylorus-preserving pancreaticoduodenectomy in the fasting state. The effect of DKT may not be related to the continuity of the intramural nerve.
Kawasaki
Naruo
N
Department of Emergency and Critical Care Medicine, St Marianna University School of Medicine, Kawasaki City, Kanagawa, Japan. naruk0501@yahoo.co.jp
Nakada
Koji
K
Suzuki
Yutaka
Y
Furukawa
Yoshiyuki
Y
Hanyu
Nobuyoshi
N
Kashiwagi
Hideyuki
H
D000818:Animals; D019540:Area Under Curve; D004285:Dogs; D004333:Drug Administration Routes; D005746:Gastric Emptying / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D023421:Models, Animal; D005894:Panax; D016577:Pancreaticoduodenectomy; D010936:Plant Extracts / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control*; D032106:Zanthoxylum; D030521:Zingiberaceae
D010936:Plant Extracts; C121414:dai-kenchu-to