Vaspin and its correlation with insulin sensitivity indices in obese children.
OBJECTIVE
The aim of this study was to assess the vaspin and adiponectin concentrations on markers of insulin sensitivity and obesity in pubertal obese children and adolescents.


METHODS
Plasma vaspin and adiponectin level and its relationships with body mass index standard deviation score (BMI-SDS), insulin sensitivity and lipids were analyzed in 33 pubertal obese children (19 girls and 14 boys) and 36 healthy control children (18 girls and 18 boys) aged 11-16 years. Insulin resistance was evaluated by homeostasis model assessment (HOMA-IR) and fasting glucose-to-insulin ratio (FGIR). Plasma vaspin and adiponectin concentrations were determined with radioimmunoassay.


RESULTS
Mean vaspin levels were found significantly higher and inversely, adiponectin levels were found significantly lower in obese pubertal group than control subjects. Vaspin levels were positively correlated with BMI-SDS, triglycerides, fasting insulin and HOMA-IR and negatively correlated with adiponectin levels and FGIR. Adiponectin levels were positively correlated with high density lipoprotein-chloesterol, FGIR and negatively correlated with vaspin, BMI-SDS, fasting insulin and HOMA-IR.


CONCLUSIONS
We found higher vaspin and lower adiponectin levels in obese children and these adipokines were significantly correlated with insulin sensitivity indices in this age.
Suleymanoglu
Selami
S
Department of Pediatrics, GATA Medical Faculty, Istanbul, Turkey. rubina_k@msn.com
Tascilar
Emre
E
Pirgon
Ozgur
O
Tapan
Serkan
S
Meral
Cihan
C
Abaci
Ayhan
A
D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood*; D012016:Reference Values; D015843:Serpins / Q000097:blood*
D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; C507339:SERPINA12 protein, human; D015843:Serpins