Comparison of tigecycline and vancomycin for treatment of experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus.
Twice-daily 7-day regimens of tigecycline (7 mg/kg) and vancomycin (50 mg/kg) were compared in a rat tissue cage model of chronic foreign-body infection due to methicillin (meticillin)-resistant Staphylococcus aureus strain MRGR3. Subcutaneously administered tigecycline reached levels in tissue cage fluid that were nearly equivalent or slightly superior to the antibiotic MIC (0.5 microg/ml) for strain MRGR3. After 7 days, equivalent, significant reductions in bacterial counts were recorded for tigecycline-treated and vancomycin-treated rats, compared with those for untreated animals.
Service of Infectious Diseases, University Hospitals of Geneva, 4 rue Gabrielle-Perret-Gentil, Geneva 14, Switzerland. Pierre.Vaudaux@hcuge.ch
Pierre
P
Vaudaux
Bénédicte
B
Fleury
Asllan
A
Gjinovci
Elzbieta
E
Huggler
Manuela
M
Tangomo-Bento
Daniel P
DP
Lew
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005547:Foreign Bodies / Q000188:drug therapy* / Q000382:microbiology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000502:physiology*; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology*; D000078304:Tigecycline; D014640:Vancomycin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D000078304:Tigecycline; D008911:Minocycline