Structural basis for self-renewal of neural progenitors in cortical neurogenesis.
In mammalian brain development, neuroepithelial cells act as progenitors that produce self-renewing and differentiating cells. Recent technical advances in live imaging and gene manipulation now enable us to investigate how neural progenitors generate the 2 different types of cells with unprecedented accuracy and resolution, shedding new light on the roles of epithelial structure in cell fate decisions and also on the plasticity of neurogenesis.
Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, Chuo-ku, Kobe, Japan.
Go
G
Shioi
Daijiro
D
Konno
Atsunori
A
Shitamukai
Fumio
F
Matsuzaki
D000818:Animals; D002454:Cell Differentiation; D051379:Mice; D008810:Mice, Inbred C57BL; D008959:Models, Neurological; D019579:Neocortex / Q000196:embryology* / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D012854:Sister Chromatid Exchange / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*