[Expression and significance of hTERT, c-myc and Ki-67 in hepatocellular carcinoma].
OBJECTIVE
To study the correlation of expression of hTERT, c-myc and Ki-67 with the clinical pathological feature of hepatocellular carcinoma and explore the relationship among the three factors.


METHODS
The expressions of hTERT, c-myc and Ki-67 in 37 cancer tissues and 5 normal tissues were assessed by immunohistochemical method.


RESULTS
The positive rates of hTERT, c-myc and Ki-67 in the cancer tissue were higher than those in normal tissues (P<0.05). The expressions of hTERT, c-myc and Ki-67 had nothing to do with age, sex, metastasis and the volume of tumor(P>0.05). With histology stage reducing, the expression of hTERT, c-myc and Ki-67 increased obviously. There is no correlation between hTERT and c-myc(P>0.05), but it's positive correlation between hTERT and Ki-67(P<0.05). With the expression of Ki-67 increasing, hTERT and c-myc increased.


CONCLUSIONS
The over-expression of hTERT, c-myc and Ki-67 may play a vital role in the progress of hepatocellular carcinoma developing. The expressions of three factors in hepatocellular carcinoma are closely associated.
Shiyou Medical School of Hebei Medical University, Langfang 065000, China. fanyongwei.1969@yahoo.com.cn
Yong-wei
YW
Fang
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*; D019098:Telomerase / Q000096:biosynthesis*
D019394:Ki-67 Antigen; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; C509186:TERT protein, human; D019098:Telomerase