Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.
Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC(50) value of 0.39 microM in a concentration-dependent manner without showing cytotoxic effects.
Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp
Yasuhiro
Y
Igarashi
Tsukasa
T
Mogi
Saeko
S
Yanase
Satoshi
S
Miyanaga
Tsuyoshi
T
Fujita
Hiroaki
H
Sakurai
Ikuo
I
Saiki
Ayumi
A
Ohsaki
D039903:Actinobacteria / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019306:Artemisia / Q000382:microbiology; D003110:Colonic Neoplasms; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014199:Trehalose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; C550819:brartemicin; D014199:Trehalose