Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes.
The antifungal effects of citral, eugenol, nerolidol and alpha-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of alpha-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and alpha-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.
Dept of Forest Sciences, Seoul National University, Gwanakgu, Seoul, Republic of Korea.
M J
MJ
Park
K S
KS
Gwak
I
I
Yang
K W
KW
Kim
E B
EB
Jeung
J W
JW
Chang
I G
IG
Choi
D000080462:Acyclic Monoterpenes; D000935:Antifungal Agents / Q000494:pharmacology*; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes / Q000494:pharmacology; D005054:Eugenol / Q000494:pharmacology*; D025301:Hyphae / Q000187:drug effects; D008854:Microscopy, Electron; D039821:Monoterpenes / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry; D012717:Sesquiterpenes / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure
D000080462:Acyclic Monoterpenes; D000935:Antifungal Agents; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D039821:Monoterpenes; D010936:Plant Extracts; D010938:Plant Oils; D012717:Sesquiterpenes; D013729:Terpenes; C016775:alpha-terpineol; D005054:Eugenol; C037055:nerolidol; C007076:citral