Prophylactic antiemetic effects of midazolam, dexamethasone, and its combination after middle ear surgery.
OBJECTIVE
To evaluate and compare the efficacy of the combination of midazolam and dexamethasone, with midazolam and dexamethasone alone, for the prevention of postoperative nausea and vomiting (PONV) in female patients undergoing middle ear surgery.


METHODS
A prospective, randomized, double-blind, placebo-controlled study in 80 female patients (mean age 32.6 years), undergoing middle ear surgery with general anesthesia at Ohud Hospital, Madina, Kingdom of Saudi Arabia from May 2007 to May 2008. Patients were classified into 4 groups. They received intravenous normal saline (S group), midazolam 0.075 mg/kg (M group), or dexamethasone 10 mg (D group), or a combination of midazolam and dexamethasone (MD group), before the induction of anesthesia. Postoperatively for 24 hours observation and assessment of nausea, vomiting, rescue anti-emetics, and side effects of the study drugs such as headache and drowsiness were carried out.


RESULTS
There was a significant difference between the 4 groups. The MD group was the least to develop PONV compared to other groups (p<0.01). Regarding nausea, there was a non-significant difference between the 4 groups, although the MD group developed the least symptoms among the 4 groups, there were no significant differences in pain intensity and side effects such as, headache, dizziness, and drowsiness between the 4 groups.


CONCLUSIONS
The combination of midazolam 0.075 mg/kg and dexamethasone 10 mg intravenously is better than either drug alone in reducing the incidence of PONV in female patients after middle ear surgery.
Makhdoom
Naeem K
NK
Department of Ear, Nose, and Throat, Faculty of Medicine, Taiba University, Madina, Kingdom of Saudi Arabia. garee22@yahoo.com
Farid
Magdy F
MF
D000328:Adult; D000932:Antiemetics / Q000008:administration & dosage* / Q000494:pharmacology; D003907:Dexamethasone / Q000008:administration & dosage* / Q000494:pharmacology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004432:Ear, Middle / Q000601:surgery*; D005260:Female; D018757:GABA Modulators / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D007262:Infusions, Intravenous; D008874:Midazolam / Q000008:administration & dosage* / Q000494:pharmacology; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011300:Preoperative Care; D011446:Prospective Studies; D012529:Saudi Arabia
D000932:Antiemetics; D018757:GABA Modulators; D003907:Dexamethasone; D008874:Midazolam