Synthesis of isoxazolo[5,4-b]pyridines by microwave-assisted multi-component reactions in water.
A series of new polycyclic-fused isoxazolo[5,4-b]pyridines were obtained by a one-pot tandem reaction under microwave irradiation in water. Without any use of additional reagent or catalyst, the synthetic protocol represents a green one and makes this methodology suitable for library synthesis in drug discovery efforts.
Tu
Shu-Jiang
SJ
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou, Jiangsu 221116, PR China. laotu2001@263.net
Zhang
Xiao-Hong
XH
Han
Zheng-Guo
ZG
Cao
Xu-Dong
XD
Wu
Shan-Shan
SS
Yan
Shu
S
Hao
Wen-Juan
WJ
Zhang
Ge
G
Ma
Ning
N
D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry
D007555:Isoxazoles; D011725:Pyridines; D054852:Small Molecule Libraries; D014867:Water