An enantioselective synthesis of (+)-(S)-[n]-gingerols via the L-proline-catalyzed aldol reaction.
An enantioselective approach to (+)-(S)-[n]-gingerols (1a-c) has been developed. The requisite stereogenic centers of target molecules are facilely constructed by the proline-catalyzed cross-aldol reaction from readily available achiral starting materials.
Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic of China.
Shichao
S
Ma
Shilei
S
Zhang
Wenhu
W
Duan
Wei
W
Wang
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002396:Catechols / Q000138:chemical synthesis* / Q000737:chemistry; D005233:Fatty Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
D000975:Antioxidants; D002396:Catechols; D005233:Fatty Alcohols; C007845:gingerol; D011392:Proline