Screening of high-risk families for pancreatic cancer.
OBJECTIVE
To discuss how to recognise and manage high-risk individuals.


RESULTS
Publication of initial results of screening for pancreatic cancer from US centres. Several masses and premalignant lesions have been detected, but the detection of the first pancreatic cancer through an organised study of screening has yet to be published. There has been progress in risk stratification; the role of diabetes in predisposing for cancer has been characterised and molecular modalities have been published which could be used in conjunction with imaging in a screening programme. A mutation in the palladin gene was found to segregate with the disease in a family with a clear predisposition for pancreatic cancer, though this has yet to be found in other such kindreds.


CONCLUSIONS
Significant challenges remain to be solved in screening for early pancreatic cancer. Risk stratification needs to be improved and high-risk patients included in research-based screening programmes. It will be impossible to confirm that screening can detect cancers early enough for curative treatment until the results of these prospective studies become available.
Division of Surgery, University of Liverpool, Liverpool, UK.
W
W
Greenhalf
C
C
Grocock
M
M
Harcus
J
J
Neoptolemos
D018395:CA-19-9 Antigen / Q000097:blood; D015331:Cohort Studies; D005190:Family; D005799:Genes, Dominant; D006801:Humans; D008403:Mass Screening / Q000379:methods; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011230:Precancerous Conditions / Q000453:epidemiology / Q000235:genetics; D018570:Risk Assessment; D013577:Syndrome
D018395:CA-19-9 Antigen