Fluoride ion and phosphines as nucleophilic catalysts: synthesis of 1,4-benzothiazepines from cyclic sulfenamides.
A new methodology, using fluoride ion as a nucleophilic catalyst, was applied for the synthesis of enantiopure 1,4-benzothiazepine from cyclic sulfenamide and electron-deficient acetylene, with high efficiency and atom economy.
Spitz
Cédric
C
Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Basse-Normandie, CNRS, 14050, Caen, France.
Lohier
Jean-François
JF
Santos
Jana Sopkova-de Oliveira
JS
Reboul
Vincent
V
Metzner
Patrick
P