Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action.
Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-terminal amino acid residue sequence, RF(Y) amide, a sequence distinct from that required for melanocortin receptor binding. A recently delineated family of RFamide receptors recognizes both of these C-terminal motifs. We now present evidence that an antagonist with Y1 and RFamide receptor activity, BIBO3304, will attenuate the central cardiovascular effects of both gamma-melanocyte stimulating hormone (gamma-MSH) and NPY. The use of synthetic melanocortin and NPY peptide analogs excluded an interaction with melanocortin or Y family receptors. We suggest that the anatomical convergence of NPY and melanocortin neurons on cardiovascular control centers may have pathophysiological implications through a common or similar RFamide receptor(s), much as they converge on other nuclei to coordinately control energy homeostasis.
Gruber
Kenneth A
KA
The Center for the Study of Weight Regulation and Associated Disorders and The Vollum Institute, Oregon Health and Science University, Portland, OR 97239-3098, USA.
Fan
Wei
W
Akerberg
Helena
H
Larhammar
Dan
D
Chee
Melissa J S
MJ
Colmers
William F
WF
Cone
Roger D
RD
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D016466:CHO Cells; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D006727:Hormone Antagonists / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D009478:Neuropeptide Y / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014666:Vasomotor System / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D019825:gamma-MSH / Q000378:metabolism / Q000502:physiology*
D006727:Hormone Antagonists; D009478:Neuropeptide Y; D019825:gamma-MSH; D001120:Arginine; C117416:BIBO 3304