[Transformation of chronic lymphocytic leukemia to myelodysplastic syndrome: case presentation and review of the literature].
Chronic lymphocytic leukaemia (CLL) may transform to either malignant lymphoid disorder or increase the occurrence of solid neoplasms. However myeloid malignancies seldom develop. We report a case of a patient who has remained untreated for CLL and developed myelodysplastic syndrome (refracter anemia with ringed sideroblasts) six years after the diagnosis of CLL. Development of myelodysplastic syndrome resulted in concurrent attenuation of CLL. Discussion of the pathogenesis of myeloid disorders occurring with CLL and review of the literature are also presented.
Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Hematológiai Tanszék, II Belgyógyászati Klinika, Belgyógyászati Intézet, Debrecen Pf. 20 4012. telekbela@yahoo.com
Béla
B
Telek
György
G
Pfliegler
Gyula
G
Reményi
Leonóra
L
Méhes
Péter
P
Batár
Miklós
M
Udvardy
D001803:Blood Transfusion; D001853:Bone Marrow / Q000473:pathology*; D003582:Cytogenetics; D005260:Female; D005434:Flow Cytometry; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000473:pathology*; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000473:pathology* / Q000628:therapy; D010976:Platelet Count
D006454:Hemoglobins