Synthesis of the DFGH ring system of type B physalins: highly oxygenated, cage-shaped molecules.
Let the dominos fall: Synthesis of the complex DFGH ring system of the title compounds has been accomplished. The approach features simple treatment of the key intermediate with a Brønsted base to afford the tetracyclic cage-shaped target in one pot through a four-step domino transformation (see scheme; Mc = monochloromesylate, MOM = methoxymethyl).
Ohkubo
Megumi
M
Synthetic Organic Chemistry Laboratory, Advanced Science Institute, RIKEN, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan.
Hirai
Go
G
Sodeoka
Mikiko
M
D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D012632:Secosteroids / Q000138:chemical synthesis* / Q000737:chemistry
D012632:Secosteroids; C033270:physalin B; D010100:Oxygen