[Function of TM4SF-integrins complexes in regulating cancer metastasis].
Distant metastasis is the main cause of cancer death. Tetraspanins (transmembrane 4 superfamily, TM4SF) is capable of forming transmembrane complexes with integrin family participating in cell adhesion, migration and tumor metastasis. This review elucidates the structure of tetraspanins and its function in regulating metastasis as form of multimolecular transmembrane complexes with integrin.
Zhu
Lin-jing
LJ
Department of Pathology, College of Medicine, Zhejiang University, Hangzhou 310058, China. zhulingjing@gmail.com
Lai
Chong
C
D002448:Cell Adhesion; D006801:Humans; D016023:Integrins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D059470:Tetraspanins
D016023:Integrins; D008565:Membrane Proteins; C109139:TSPAN4 protein, human; D059470:Tetraspanins