Radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater: a case report.
OBJECTIVE
Radiation-induced tumors are a rare complication of radiation therapy. Here, we describe the first case of a radiation-induced osteosarcoma with a rhabdomyosarcoma component arising from the dura mater after radiation therapy for an astrocytoma.


METHODS
An 18-year-old man with generalized seizures presented with a neoplastic lesion in the dura mater of a previously irradiated (56 Gy) region 5 years after the initial radiation therapy. A tumor resection was performed, and histological examination revealed an osteosarcoma with a rhabdomyosarcoma component. The tumor recurred despite eight tumorectomies and the addition of chemotherapy and radiotherapy. The patient died from tumor progression 5 years after the first surgical removal of the radiation-induced tumor.


CONCLUSIONS
This radiation-induced tumor may have originated from primitive, multipotent mesenchymal cells, as it included both osteosarcoma and rhabdomyosarcoma components.
Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. utsuki@med.kitasato-u.ac.jp
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Utsuki
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Oka
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Sato
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Shimizu
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Suzuki
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Fujii
D000293:Adolescent; D001254:Astrocytoma / Q000473:pathology / Q000532:radiotherapy*; D001921:Brain / Q000473:pathology; D004388:Dura Mater; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D012516:Osteosarcoma / Q000209:etiology* / Q000473:pathology; D011880:Radiotherapy Planning, Computer-Assisted; D012208:Rhabdomyosarcoma / Q000209:etiology* / Q000473:pathology*