Comparison of the rates of joint arthroplasty in patients with severe factor VIII and IX deficiency: an index of different clinical severity of the 2 coagulation disorders.
Data from the Italian Hemophilia Centres were collected to perform a retrospective survey of joint arthroplasty in patients with severe hemophilia. Twenty-nine of 49 hemophilia centers reported that 328 of the 347 operations were carried out in 253 patients with severe hemophilia A (HA) and 19 in 15 patients with severe hemophilia B (HB). When results were normalized to the whole Italian hemophilia population (1770 severe HA and 319 severe HB), patients with HA had a 3-fold higher risk of undergoing joint arthroplasty (odds ratio [OR], 3.38; 95% confidence interval [CI], 1.97-5.77; P < .001). These results were confirmed after adjustment for age, HIV, hepatitis C virus (HCV), and inhibitor in a Cox regression model (HR, 2.65; 95% CI, 1.62-4.33; P < .001). The survival analysis of time to joint arthroplasty in the subset of patients with severe HA was not affected by the severity of factor VIII (FVIII) gene mutations. A systematic review of literature articles reporting joint arthroplasties in HA and HB showed that the proportion of HA patients who had undergone arthroplasties was higher than that of HB patients, in agreement with the findings in our Italian cohort. These data suggest that the 2 inherited coagulation disorders have a different severity of clinical phenotype.
Transfusion Service, Hemophilia and Regional Blood Disease Centre, Castelfranco Veneto, Via Ospedale 18, Castelfranco Veneto (TV), Italy. giuseppe.tagariello@ulssasolo.ven.it
Giuseppe
G
Tagariello
Alfonso
A
Iorio
Elena
E
Santagostino
Massimo
M
Morfini
Ruggero
R
Bisson
Massimo
M
Innocenti
Maria Elisa
ME
Mancuso
Maria Gabriella
MG
Mazzucconi
Gian Luigi
GL
Pasta
Paolo
P
Radossi
Giuseppina
G
Rodorigo
Cristina
C
Santoro
Roberto
R
Sartori
Antonio
A
Scaraggi
Luigi Pier
LP
Solimeno
Pier Mannuccio
PM
Mannucci
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001178:Arthroplasty / Q000706:statistics & numerical data*; D001778:Blood Coagulation Disorders / Q000145:classification / Q000150:complications / Q000453:epidemiology / Q000601:surgery; D002648:Child; D015331:Cohort Studies; D006467:Hemophilia A / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D002836:Hemophilia B / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007592:Joint Diseases / Q000150:complications / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery*; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult