Prospects for treatment of pediatric vitreoretinal diseases with vascular endothelial growth factor inhibition.
While angiogenesis inhibitors are already widely used to treat retinal disease in adults, only limited reports are currently available for the use of anti-VEGF in pediatric vitreoretinal diseases such as retinopathy of prematurity, Coats' disease, familial exudative vitreoretinopathy and retinopathy of incontinentia pigmenti. The limited trials of anti-VEGF therapy for pediatric vitreoretinal diseases are promising, although more extensive controlled trials will be needed to confirm their safety and efficacy. This paper will examine the current evidence for use of anti-VEGF therapy in a number of pediatric vitreoretinal disorders and describe a case of anti-VEGF therapy in retinopathy of incontinentia pigmenti.
Lin
Kristie L
KL
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA. Kristie.Lin@gmail.com
Hirose
Tatsuo
T
Kroll
Arnold J
AJ
Lou
Peter L
PL
Ryan
Edward A
EA
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D005123:Eye / Q000098:blood supply; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D007184:Incontinentia Pigmenti / Q000150:complications; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000209:etiology; D011300:Preoperative Care; D012163:Retinal Detachment / Q000209:etiology / Q000601:surgery; D012164:Retinal Diseases / Q000188:drug therapy*; D012171:Retinal Vessels / Q000002:abnormalities; D012178:Retinopathy of Prematurity / Q000188:drug therapy; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*; D014822:Vitreous Body / Q000098:blood supply
D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab