The relationship among symptoms, sleep disturbances and quality of life in patients with interstitial cystitis.
OBJECTIVE
We conducted a retrospective analysis to determine associations among symptoms, sleep disturbances and quality of life in responder and nonresponder groups of patients with interstitial cystitis.


METHODS
Patients in a multidose pentosan polysulfate sodium clinical trial with a diagnosis of interstitial cystitis who were randomized to 300 mg pentosan polysulfate sodium per day (128) completed the Interstitial Cystitis Symptom Index, an adapted Medical Outcomes Study Sleep scale and the Medical Outcomes Study Short Form-12 Health Survey at baseline, and at weeks 8, 16, 24 and 32. Responders were defined as those achieving a 30% or greater reduction in Interstitial Cystitis Symptom Index score from baseline to study end point (week 32 or last observation carried forward).


RESULTS
A positive correlation at baseline was observed between sleep scores and Short Form-12 physical and mental components (r = 0.43 and 0.37, respectively, p <0.0001). Patients showed statistically significant improvement in Interstitial Cystitis Symptom Index and sleep scores by week 32. Responders (48, 43%) had a mean change in sleep score of 11.8 +/- 22.4 while nonresponders (64, 57%) had a mean change of 1.6 +/- 15.7 (p = 0.0055 between groups). The reduction in Interstitial Cystitis Symptom Index score correlated with improvement in sleep score from baseline to study end point (r = -0.33, p = 0.0003). At the study end point responders demonstrated a significant improvement in the Short Form-12 physical component compared with baseline (p <0.0001).


CONCLUSIONS
Reduction in interstitial cystitis symptoms may be associated with patient reported improvement in sleep and quality of life.
Nickel
J Curtis
JC
Queen's University, Kingston, Ontario, Canada. jcn@queensu.ca
Payne
Christopher K
CK
Forrest
John
J
Parsons
C Lowell
CL
Wan
George J
GJ
Xiao
Xiaoying
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018856:Cystitis, Interstitial / Q000150:complications* / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use*; D011788:Quality of Life; D012189:Retrospective Studies; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000517:prevention & control*; D055815:Young Adult
D010426:Pentosan Sulfuric Polyester