Identification of Ecl family genes that extend chronological lifespan in fission yeast.
In fission yeast, we identified two genes, named ecl2+ and ecl3+, that are paralogous to ecl1+, which extends the chronological lifespan. Both ecl2+ and ecl3+ extend the chronological lifespan when overexpressed as ecl1+. ecl2+ and ecl3+ encode 84- and 89-amino acid polypeptides respectively that are not annotated in the current database. The Ecl2 protein is localized mainly in the nucleus, as Ecl1. These results suggest that ecl1+, ecl2+, and ecl3+ have overlapping functions in the regulation of chronological lifespan.
Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.
Hokuto
H
Ohtsuka
Yuki
Y
Ogawa
Hiroyuki
H
Mizuno
Satoka
S
Mita
Hirofumi
H
Aiba
D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism*; D018384:Oxidative Stress / Q000235:genetics; D021381:Protein Transport; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012568:Schizosaccharomyces / Q000166:cytology / Q000235:genetics* / Q000254:growth & development*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics* / Q000378:metabolism*; D013997:Time Factors; D014158:Transcription, Genetic
C541523:Ecl2 protein, S pombe; C541524:Ecl3 protein, S pombe; D009687:Nuclear Proteins; D012333:RNA, Messenger; D029702:Schizosaccharomyces pombe Proteins