A non-element-enriched, non-lyophilized candidate rat serum reference material prepared for once use in determination of inorganic elements by ICP-MS.
A practice about preparing a once-used native state candidate rat serum reference material has been described for inductively coupled plasma atomic emission spectrometry (ICP-MS) determination of inorganic elements in biological matrices, which is independently packed, easy to use, non-lyophilized, without element-spiking, and with stable quality. Various dispersing and storing factors influencing the serum quality have been investigated including container material, sampling volume, packing mode and storage time. The contents of twelve main elements in the rat serum have been not only evaluated by ICP-MS but also verified by other analytical techniques. The probation of this unconventional candidate serum reference material by different laboratories has given very similar contents of 12 main trace elements in the serum, and proven its applicability to support quality assurance of biological sample analyses.
Li
Xiang-Yun
XY
Key Laboratory of Analytical Chemistry for Life Science (Ministry of Education of China), School of Chemistry and Chemical Engineering, Center of Materials Analysis, Nanjing University, 22 Hankou Road, Nanjing 210093, China.
Lian
Hong-Zhen
HZ
Mao
Li
L
Chen
Yi-Jun
YJ
Hu
Xin
X
Qiao
Jun-qin
JQ
Sheng
Dong
D
D000818:Animals; D019216:Metals, Heavy / Q000097:blood / Q000592:standards; D015588:Observer Variation; D051381:Rats; D012015:Reference Standards; D013054:Spectrophotometry, Atomic / Q000379:methods*; D014131:Trace Elements / Q000097:blood* / Q000592:standards
D019216:Metals, Heavy; D014131:Trace Elements