Serum uric acid levels improve prediction of incident type 2 diabetes in individuals with impaired fasting glucose: the Rancho Bernardo Study.
OBJECTIVE
To determine whether serum uric acid predicts incident type 2 diabetes by glucose tolerance status in older community-dwelling adults.


METHODS
Participants without diabetes at baseline were evaluated for incident type 2 diabetes 13 years later. Baseline glucose tolerance status was defined as normoglycemia, impaired fasting glucose, and impaired postchallenge glucose tolerance.


RESULTS
A total of 566 participants were included (mean age 63.3 +/- 8.6 years; 41% men). Regression models adjusted for age, sex, BMI, diuretic use, and estimated glomerular filtration rate showed that for each 1 mg/dl increment in uric acid levels, incident type 2 diabetes risk increased by approximately 60%. When analyses were stratified by glucose status, uric acid levels independently predicted incident type 2 diabetes among participants who had impaired fasting glucose (odds ratio 1.75, 95% CI 1.1-2.9, P = 0.02).


CONCLUSIONS
Uric acid may be a useful predictor of type 2 diabetes in older adults with impaired fasting glucose.
Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Caroline Kaercher
CK
Kramer
Denise
D
von Mühlen
Simerjot Kaur
SK
Jassal
Elizabeth
E
Barrett-Connor
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005215:Fasting; D005260:Female; D005919:Glomerular Filtration Rate; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D001786:Blood Glucose; D014527:Uric Acid