Epidemiological situation of malaria in Madagascar: baseline data for monitoring the impact of malaria control programmes using serological markers.
The aim of this study was to provide baseline information of the epidemiological situation of malaria in Madagascar using serological markers. We carried out cross-sectional studies in schoolchildren from eight sites in the four different malarious epidemiological strata of Madagascar. We studied the prevalence of anti-MSP1 antibodies to assess the burden, and anti-CSP antibodies to estimate the transmission intensity, of malaria. The overall prevalence of each antibody tested was 46.1% for anti-PfMSP-1, 15.2% for anti-PvMSP-1, 14.9% for anti-PfCSP, 4.9% for anti-PvCSP and 2.4% for anti-PmCSP. The prevalence of the five antibodies varied significantly between the sites (P<10(-6)). We also found significant effects of ethnic origin on the prevalence of anti-PfMSP1 antibodies. With regular testing in the same target populations, this data will be particularly useful for managing the elimination strategy supported by the Malagasy Government.
Razakandrainibe
Romy
R
Immunology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Thonier
Vincent
V
Ratsimbasoa
Arsène
A
Rakotomalala
Emma
E
Ravaoarisoa
Elisabeth
E
Raherinjafy
Rogelin
R
Andrianantenaina
Herilalaina
H
Voahanginirina
Odette
O
Rahasana
Tiana Eugénie
TE
Carod
Jean François
JF
Domarle
Olivier
O
Menard
Didier
D
D000293:Adolescent; D000913:Antibodies, Protozoan / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D005843:Geography; D006801:Humans; D008270:Madagascar / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology*; D008297:Male; D020066:Merozoite Surface Protein 1 / Q000276:immunology; D016036:Seroepidemiologic Studies
D000913:Antibodies, Protozoan; D020066:Merozoite Surface Protein 1