Optimal dosage of ultrasound contrast agent for ultrasound surgery: thermal effect of linear plane wave.
The optimal dosage of ultrasound contrast agent model for ultrasound surgery was explored. A specific ultrasound contrast agent Albunex was chosen for simulation. The model was developed based on a dilute bubbly liquid model proposed by Ye and Ding [Z. Ye, L. Ding, Acoustic dispersion and attenuation relations in bubbly mixture, J. Acoust. Soc. Am. 98 (3) (1995) 1629-1636]. The numerical simulation suggests that 2 MHz is more efficient than 1 MHz to thermally treat cancer in deep tissue with the optimal dosage of 3 ml. On the other hand, the simulation also suggests 3 MHz center frequency with the optimal dosage of 1.6 ml is adequate for prostate cancer treatment with transrectal equipment. The simulation is expected to valid up to 2 MPa incident pressure due to the limitation of the linearized UCA model. Even though it is developed from a single ultrasound contrast agent, this model is expected to be useful for any ultrasound contrast agent as long as the necessary parameters are provided.
Seo
Jongbum
J
jongbums@yonsei.ac.kr
D000418:Albumins / Q000008:administration & dosage*; D003198:Computer Simulation; D003287:Contrast Media / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D017711:Nonlinear Dynamics; D011312:Pressure; D014464:Ultrasonic Therapy / Q000295:instrumentation / Q000379:methods*
D000418:Albumins; C060687:Albunex; D003287:Contrast Media