Leave methamphetamine to be alive--Part II.
Series of experiments have been completed with Methamphetamine (MA). Some were with the higher, medium or lower duration of MA administration and some were with acute or chronic doses. Whatever may be the dose or duration the ultimate result came out with the further establishment of cardio-toxic effect of this drug. Cardiovascular symptoms related to MA toxicity include chest pain, palpitations, dyspnoea, hypertension, tachycardia, atrial and ventricular arrhythmias, and myocardial ischemia. MA abusers often go through a repeated pattern of frequent drug administrations followed by a period of abstinence. Previous studies have focused largely upon the chronic effect of MA intake to major organs, such as the brains and the heart, by using animal experiments. However, there is a lack of research into the effects of acute dose of MA, especially pertaining to the heart. To clarify the effect of MA on myocardium, 22 male Wister rats aged six weeks were divided into MA, Placebo (P) and Control (C) group were examined following single intraperitoneal administration of MA at a dose of 50 mg/kg body weight. Normal saline was similarly injected in P group. Light microscopic changes was seen in the myocardium of MA treated group including cellular infiltration, with clusters of macrophage-like cells having large nuclei and little cytoplasm evident in the sub-endocardium region. There were presence of few macrophages, leucocytes, and spindle-like fibroblasts. Bringing in to account of cardiac changes by a single dose of MA, slogan should be voiced out to leave methamphetamine.
Faculty of Medicine, Universiti Tekhologi MARA, 40450 Shah Alam, Selangor, Malaysia. nasimevu@yahoo.com
Mohammed Nasimul
MN
Islam
Jesmine
J
Khan
Hasnan
H
Jaafar
D000818:Animals; D002467:Cell Nucleus / Q000473:pathology; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D049429:Forensic Pathology; D053593:Forensic Toxicology; D006321:Heart / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008264:Macrophages / Q000473:pathology; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D008853:Microscopy; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D000697:Central Nervous System Stimulants; D008694:Methamphetamine