[Axonal mRNAs: from histochemical visualization to functional analyses].
The vertebrate neuron axon has long been considered as devoid of the protein synthesis machinery. During the early nineties however, the cytochemical visualization of identified mRNAs within certain rodent neuron axons challenged this dogma of cellular neurobiology. The aim of this paper is to illustrate, taking mainly the mouse olfactory system as an example, conceptual and methodological approaches developed in particular in my group, that aim at identifying the function of these axonal mRNAs.
Equipe Avenir/INSERM Développement et Plasticité des Réseaux Neuronaux, CNRS UMR 7102, Université Pierre et Marie Curie - Paris 6, Boîte 12, 9 quai St Bernard, 75005 Paris, France. alain.trembleau@upmc.fr
Alain
A
Trembleau
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000378:metabolism* / Q000648:ultrastructure; D051379:Mice; D008954:Models, Biological; D009416:Nerve Regeneration / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D009832:Olfactory Nerve / Q000166:cytology / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics*; D051381:Rats; D012584:Sciatic Nerve / Q000502:physiology
D009419:Nerve Tissue Proteins; D012333:RNA, Messenger