BNCT for skin melanoma in extremities: updated Argentine clinical results.
As part of phase I/II melanoma BNCT clinical trial conducted in Argentina in a cooperative effort of the Argentine Atomic Energy Commission (CNEA) and the Oncology Institute Angel H. Roffo (IOAHR), 7 patients (6 female-1 male) received eight treatment sessions covering ten anatomical areas located in extremities. Mean age of the patients was 64 years (51-74). The treatments were performed between October 2003 and June 2007. All patients presented multiple subcutaneous skin metastases of melanoma and received an infusion containing approximately 14 gr/m(2) of (10)borophenyl-alanine (BPA) followed by the exposition of the area to a mixed thermal-epithermal neutron beam at the RA-6 reactor. The maximum prescribed dose to normal skin ranged from 16.5 to 24 Gy-Eq and normal tissue administered dose varied from 15.8 to 27.5 Gy-Eq. Considering evaluable nodules, 69.3% of overall response and 30.7% of no changes were seen. The toxicity was acceptable, with 3 out of 10 evaluable areas showing ulceration (30% toxicity grade 3).
Menéndez
P R
PR
Instituto de Oncología Angel H. Roffo. Av. San Martín 5481, (1417) Cdad. de Buenos Aires, Argentina. pmenende@yahoo.com
Roth
B M C
BM
Pereira
M D
MD
Casal
M R
MR
González
S J
SJ
Feld
D B
DB
Santa Cruz
G A
GA
Kessler
J
J
Longhino
J
J
Blaumann
H
H
Jiménez Rebagliati
R
R
Calzetta Larrieu
O A
OA
Fernández
C
C
Nievas
S I
SI
Liberman
S J
SJ
D000368:Aged; D001118:Argentina; D001896:Boron Compounds / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012878:Skin Neoplasms / Q000532:radiotherapy*
D001896:Boron Compounds; D011838:Radiation-Sensitizing Agents; D010649:Phenylalanine; C033685:4-boronophenylalanine