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Two mammalian mitochondrial transcription factors (TFB1M and TFB2M) share homology with universally expressed dimethyltransferases that modify conserved adenines in the small ribosomal subunit rRNA. Work in this issue (Metodiev et al., 2009) shows that loss of TFB1M abolishes mitochondrial ribosome assembly without affecting mitochondrial transcription.
Department of Human Genetics, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A 2B4, Canada. eric@ericpc.mni.mcgill.ca
Eric A
EA
Shoubridge
D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics; D008745:Methylation; D051379:Mice; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D014176:Protein Biosynthesis; D012335:RNA, Ribosomal / Q000378:metabolism; D054682:Ribosome Subunits, Small, Eukaryotic / Q000378:metabolism; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D004272:DNA, Mitochondrial; D012335:RNA, Ribosomal; C075526:RNA, ribosomal, 12S; C462441:Tfb1m protein, mouse; D014157:Transcription Factors