Indomethacin-induced colon perforation in Bartter's syndrome.
Bartter's syndrome (BS) is an inherited renal tubular disorder characterized by hypokalemia, hypochloremic metabolic alkalosis, and hyperaldosteronism with normal blood pressure. A 22-year-old woman was referred at 23 week of gestation. Polyhydramnios was detected and the chloride level of the amniotic fluid was high. The mother was treated with indomethacin from 26 to 31 week of gestation. The newborn was delivered at 34 week of gestation. At 8th day of life, indomethacin was also started for the baby. After three days, a colonic perforation developed. Indomethacin-induced colon perforation is uncommon in antenatal Bartter's syndrome. This patient indicates that administration of indomethacin in both antenatal and/or early postnatal period may be associated with colonic perforation.
Department of Neonatology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Emel
E
Ataoglu
Mahmut
M
Civilibal
Ayse Ayaz
AA
Ozkul
Ipek Guney
IG
Varal
Elmas Reyhan
ER
Oktay
Elevli
E
Murat
D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001477:Bartter Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D003108:Colonic Diseases / Q000150:complications / Q000235:genetics; D005260:Female; D005865:Gestational Age; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D007231:Infant, Newborn; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000150:complications / Q000235:genetics; D009154:Mutation; D006831:Polyhydramnios / Q000188:drug therapy* / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin