Area at risk and viability after myocardial ischemia and reperfusion can be determined by contrast-enhanced cardiac magnetic resonance imaging.
OBJECTIVE
Clinical differentiation between infarcted and viable myocardium in the ischemic area at risk is controversial. We investigated the potential of contrast-enhanced cardiac magnetic resonance imaging (ceCMRI) in determining the area at risk 24 h after ischemia.


METHODS
Myocardial ischemia was induced by percutaneous coronary intervention of the left anterior descending coronary artery in pigs. Coronary occlusion time was 30 min in group A, which caused little myocardial infarction and 45 min in group B, which led to irreversible damage. 24 h after reperfusion ceCMRI was performed at 2 and 15 min after administration of gadolinium-diethylenetriamine pentaacetic acid. The area at risk was determined by intravenous injection of Evans blue and myocardial viability by triphenyltetrazolium-chloride staining.


RESULTS
The signal-intense areas at 2 and 15 min after contrast administration matched the area at risk in groups A and B. Nonviable myocardium in group A was overestimated (14-15%) while good agreement was present in group B.


CONCLUSIONS
The area at risk of reperfused ischemic myocardium can be determined by ceCMRI 24 h after coronary recanalization. This type of information might have relevant clinical implications in the treatment and stratification of patients with acute coronary syndrome in particular after surgical interventions.
Vosseler
M
M
2nd Medical Clinic, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, Mainz, Germany.
Abegunewardene
N
N
Hoffmann
N
N
Petersen
S E
SE
Becker
D
D
Cleppien
D
D
Kunz
P
P
Kreitner
K-F
KF
Lauterbach
M
M
Bierbach
B
B
Düber
C
C
Gori
T
T
Munzel
T
T
Schreiber
L M
LM
Horstick
G
G
D000818:Animals; D002470:Cell Survival; D017023:Coronary Angiography; D005260:Female; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D013552:Swine; D014022:Tissue Survival
D019786:Gadolinium DTPA