Sulfonylurea treatment in a girl with neonatal diabetes (KCNJ11 R201H) and celiac disease: impact of low compliance to the gluten free diet.
A girl with celiac disease and KCNJ11 mutation was transferred to glibenclamide when 19.8 years old. When her compliance to the gluten free diet worsened, her metabolic control deteriorated. Since glibenclamide is absorbed in the intestine, its absorption seems to be impaired by chronic malabsorption, increasing the risk of hyperglycaemia.
Delvecchio
Maurizio
M
Department of Develpmental Age, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. m.delvecchio@email.it
Zecchino
Clara
C
Faienza
Maria Felicia
MF
Acquafredda
Angelo
A
Barbetti
Fabrizio
F
Cavallo
Luciano
L
D019943:Amino Acid Substitution; D001323:Autoantibodies / Q000097:blood; D003920:Diabetes Mellitus / Q000178:diet therapy / Q000188:drug therapy* / Q000523:psychology; D055050:Diet, Gluten-Free; D005260:Female; D005905:Glyburide / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007231:Infant, Newborn; D007328:Insulin / Q000627:therapeutic use; D007408:Intestinal Absorption; D010349:Patient Compliance; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D013453:Sulfonylurea Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011503:Transglutaminases / Q000276:immunology; D055815:Young Adult; D000099161:Kcnj11 Channel
D001323:Autoantibodies; D005905:Glyburide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D024661:Potassium Channels, Inwardly Rectifying; D013453:Sulfonylurea Compounds; D011503:Transglutaminases; D000099161:Kcnj11 Channel