Pathogen recognition by innate immunity and its signaling.
Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.
Akira
Shizuo
S
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan. sakira@biken.osaka-u.ac.jp
D000818:Animals; D000917:Antibody Formation; D017951:Antigen Presentation / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007111:Immunity, Cellular; D007113:Immunity, Innate; D009369:Neoplasms / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology
D016207:Cytokines; D051193:Toll-Like Receptors