A facile preparation of trehalose analogues: 1,1-thiodisaccharides.
The synthesis of 1,1-thiodisaccharide trehalose analogues in good to excellent yields by a Lewis acid (BF(3).Et(2)O)-catalysed coupling of sugar per-O-acetate with thiosugar is described. The reactivity of different sugar per-O-acetates and thiosugars is explored.
Morais
Goreti Ribeiro
GR
Institute of Cancer Therapeutics, School of Life Sciences, University of Bradford, Bradford, UK.
Humphrey
Andrew J
AJ
Falconer
Robert A
RA
D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014199:Trehalose / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
D004187:Disaccharides; D014199:Trehalose