Beta radiation for glaucoma surgery.
BACKGROUND
The outcome of glaucoma surgery can be affected by the rate at which the surgical wound heals. Beta radiation has been proposed as a rapid and simple treatment to slow down the healing response.


OBJECTIVE
To assess the effectiveness of beta radiation during glaucoma surgery (trabeculectomy).


METHODS
We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (which includes the Cochrane Eyes and Vision Group Trials Register) (Issue 4 2008), MEDLINE (January 1966 to October 2008) and EMBASE (January 1980 to October 2008). The databases were last searched on 24 October 2008.


METHODS
We included randomised controlled trials comparing trabeculectomy with beta radiation to trabeculectomy without beta radiation.


METHODS
We collected data on surgical failure (intraocular pressure > 21 mmHg), intraocular pressure and adverse effects of glaucoma surgery. We pooled data using a fixed-effect model.


RESULTS
We found four trials that randomised 551 people to trabeculectomy with beta irradiation versus trabeculectomy alone. Two trials were in Caucasian people (126 people), one trial in black African people (320 people) and one trial in Chinese people (105 people). People who had trabeculectomy with beta irradiation had a lower risk of surgical failure compared to people who had trabeculectomy alone (pooled risk ratio (RR) 0.23 (95% CI 0.14 to 0.40). Beta irradiation was associated with an increased risk of cataract (RR 2.89, 95% CI 1.39 to 6.0).


CONCLUSIONS
Trabeculectomy with beta irradiation has a lower risk of surgical failure compared to trabeculectomy alone. A trial of beta irradiation versus anti-metabolite is warranted.
Department of Ophthalmology, Queen Alexandra Hospital, Cosham, Portsmouth, Hampshire, UK, PO6 3LY. jfkirwan@mac.com
James F
JF
Kirwan
Christina
C
Rennie
Jennifer R
JR
Evans
D001610:Beta Particles / Q000009:adverse effects / Q000627:therapeutic use*; D002386:Cataract / Q000209:etiology; D003131:Combined Modality Therapy / Q000379:methods; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D014130:Trabeculectomy / Q000379:methods; D016896:Treatment Outcome; D014945:Wound Healing / Q000528:radiation effects*