[Lymphocyte metabolism in children with extensive burns].
The results of the study lead to the conclusion that the development of burn disease in children is accompanied by significant lymphocytic structural metabolic changes that determine the functional capabilities of cells and the immune system as a whole. There is an evident activation of the glutathione antioxidant system, a drastic activation of enzymes that ensure Krebs cycle reactions, as well as activation of anaerobic processes. The above changes are mainly caused by the activated sympathoadrenal system that is characteristic of stresses. The knowledge about the metabolic mechanisms responsible for the development of cellular reactions to burn shock and burn disease permits specification of the elements of the pathogenesis of these severe conditions and substantiation of the possibility of using metabolic correction in the complex treatment of children with the above pathology.
Artem'ev
S A
SA
Nazarov
I P
IP
Kamzalakova
N I
NI
Bulygin
G V
GV
D002056:Burns / Q000097:blood* / Q000150:complications; D016022:Case-Control Studies; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D002675:Child, Preschool; D002952:Citric Acid Cycle / Q000502:physiology; D006801:Humans; D007223:Infant; D050356:Lipid Metabolism; D008214:Lymphocytes / Q000201:enzymology* / Q000378:metabolism*; D008564:Membrane Potentials / Q000502:physiology; D012774:Shock, Traumatic / Q000097:blood* / Q000209:etiology