Wilms tumor, AML and medulloblastoma in a child with cancer prone syndrome of total premature chromatid separation and Fanconi anemia.
Wilms tumor (WT) is the most common primary renal tumor in childhood. The occurrence of WT in patients with growth retardation, mental retardation and central nervous system abnormalities in association with premature chromatid separation (PCS) and mosaic variegated aneuploidy has been previously described in only 10 patients. Here we report the very rare occurrence of WT with two other malignancies, acute myeloid leukemia and medulloblastoma in association with chromosomal instability. This is a novel presentation of Fanconi anemia with this cytogenetic abnormality.
Department of Pediatric Oncology, Ankara Oncology Hospital, Ankara, Turkey. neriman@meddata.com.tr
Neriman
N
Sari
Canan
C
Akyuz
Dilek
D
Aktas
Fatma
F
Gumruk
Diclehan
D
Orhan
Mehmet
M
Alikasifoglu
Burca
B
Aydin
Yasemin
Y
Alanay
Munevver
M
Buyukpamukcu
D000015:Abnormalities, Multiple; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D002675:Child, Preschool; D049914:DNA Repair-Deficiency Disorders / Q000150:complications* / Q000473:pathology; D005199:Fanconi Anemia / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008527:Medulloblastoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009396:Wilms Tumor / Q000150:complications* / Q000188:drug therapy / Q000473:pathology