[The role of renin-angiotensin system in the pathogenesis of atherosclerosis].
The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the initiation and progression of atherosclerosis, thereby contributing to development of cardiovascular diseases. Angiotensin II (Ang II), a major substrate in RAS, stimulates atherosclerosis through various deleterious effects such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic actions of Ang II are mediated by reactive oxygen species (ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy.
Hirata
Yoichiro
Y
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School.
Fukuda
Daiju
D
Sata
Masataka
M
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D017382:Reactive Oxygen Species / Q000494:pharmacology; D012084:Renin-Angiotensin System / Q000502:physiology*
D017382:Reactive Oxygen Species; D000804:Angiotensin II