The effect of low-dose inhaled budesonide on PC20 AMP levels in patients with mild asthma: a 3-month follow-up study.
Adenosine monophosphate (AMP) challenge is a diagnostic tool for asthma. The aim of this study is to evaluate the effect of low dose inhaled budesonide (IB) on PC(20)AMP levels. Seventeen stable mild asthmatic patients were prospectively recruited. After initial testing, patients were administered 400 microg of inhaled budesonide. AMP challenge was then repeated at the 12th hour and 5th,15th, 30th, and 90th days of the treatment. AMP challenge resulted in negative in 47% of the patients at 12(-)hour testing. This study suggests that low-dose IB may return airway responsiveness as early as 12 hours and AMP challenge may be effectively used for treatment monitorization.
Kokturk
Nurdan
N
School of Medicine, Department of Pulmonary Medicine, Gazi University, Ankara, Turkey. kokturk.nurdan@gmail.com
Mullaoglu
Sema
S
Ozyilmaz
Ezgi
E
Turktas
Haluk
H
D000249:Adenosine Monophosphate; D000280:Administration, Inhalation; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D019819:Budesonide / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D011446:Prospective Studies
D000893:Anti-Inflammatory Agents; D000249:Adenosine Monophosphate; D019819:Budesonide