Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort.
BACKGROUND
The H-allele of the R298H polymorphism in the prostaglandin E synthase 2 (PTGES2) gene was associated with lower risk of diabetes type 2.


OBJECTIVE
To explore the association between the PTGES2 R298H SNP and body mass index (BMI).


METHODS
We analyzed the R298H SNP (rs13283456) and three haplotype single-nucleotide polymorphisms (rs884115, rs10987883, and rs4837240) covering a 20 kb gene region in population-based surveys of the Kooperative Gesundheitsforschung in der Region Augsburg study cohort with 8079 participants.


RESULTS
A statistically significant difference in BMI between the heterozygous PTGES2 R298H genotype and the homozygous R/R genotype was found in males but not in females. Males with the R/H genotype showed a decrease in BMI of -0.30 BMI units (95% CI: -0.55, -0.04, p = 0.02) in comparison to R/R males. A haplotype comprising the minor allele of PTGES2 R298H showed a significant decrease of -0.23 BMI units in males (-0.45, -0.02; p = 0.04) but not in females. Other haplotypes and haplotype single-nucleotide polymorphisms were not significantly associated with BMI.


CONCLUSIONS
We found a marginal but significant influence of the PTGES2 298H SNP on BMI in a large population-based study.
Department of Molecular Prevention, Institute of Human Nutrition and Food Science, Christian-Albrecht-University, Kiel, Germany.
Alexandra
A
Fischer
Harald
H
Grallert
Mike
M
Böhme
Christian
C
Gieger
Inka
I
Boomgaarden
Iris
I
Heid
H-Erich
HE
Wichmann
Frank
F
Döring
Thomas
T
Illig
D000328:Adult; D000368:Aged; D000483:Alleles; D015992:Body Mass Index; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D000071876:Prostaglandin-E Synthases; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors
D019746:Intramolecular Oxidoreductases; C000605863:PTGES2 protein, human; D000071876:Prostaglandin-E Synthases