Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults.
This study compared serum antibody titers and granzyme B (GrzB) levels in virus-stimulated peripheral blood mononuclear cells following influenza vaccination. Twelve of 239 older adults who subsequently developed laboratory-diagnosed influenza illness (LDI) had significantly lower GrzB levels compared to subjects without LDI (p=0.004). Eight subjects with LDI in the previous year showed an enhanced GrzB response to vaccination (p=0.02). Serum antibody titers following vaccination did not distinguish those older adults who developed LDI from those who did not. These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults.
McElhaney
Janet E
JE
Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, 06030, USA. jmcelhaney@uchc.edu
Ewen
Catherine
C
Zhou
Xin
X
Kane
Kevin P
KP
Xie
Dongxu
D
Hager
W David
WD
Barry
Mary Beth
MB
Kleppinger
Alison
A
Wang
Yazhen
Y
Bleackley
R Chris
RC
D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D002478:Cells, Cultured; D005260:Female; D053804:Granzymes / Q000097:blood*; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014611:Vaccination
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D053804:Granzymes