Biomolecular assembly by iterative oxime ligations.
Herein we describe an iterative oxime-based procedure to prepare multivalent bioconjugates. Our approach is illustrated by the assembly of structurally diverse tetravalent and a new generation of hexadecavalent glycoclusters.
Renaudet
Olivier
O
Département de Chimie Moléculaire, UMR-CNRS 5250, ICMG FR 2607, Université Joseph Fourier, Grenoble, France.
Boturyn
Didier
D
Dumy
Pascal
P
D002851:Chromatography, High Pressure Liquid; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
D006001:Glycoconjugates; D010091:Oximes; D010456:Peptides, Cyclic