[Urinary protein to creatinine ratio and urinary sediments are useful for the screening of chronic kidney disease].
Chronic Kidney Disease (CKD) is an important risk factor of the End Stage Renal Disease (ESRD). In this study, we investigated whether the protein to creatinine ratio (the ratio of P/C) determined by the semiquantitative urinary stick test and urinary sediments are useful for the early detection of CKD. One hundred sixty patients were classified to four or five groups by P/C ratio and various biochemical markers were analyzed. As a result, the 300 mg/g x Cr of P/C group showed a significantly increased serum cystatin C level. The positive rate of the P/C ratio in CKD stage was significantly increased compared with the conventional protein qualitative analysis. Further, the amounts of urinary sediments in CKD stage 1 to 2 were increased, such as hyaline cast, and pathological casts were increased in CKD stage 3 to 5. Thus, our present study suggests that the ratio of P/C and urinary sediments are useful for the screening of CKD.
Division of Clinical Laboratory, Gifu University Hospital, Gifu 501-1194, Japan.
Saori
S
Kobayashi
Masato
M
Hoshi
Isao
I
Inagaki
Takayuki
T
Hattori
Seiko
S
Ushimaru
Hazuki
H
Ohashi
Nobuyuki
N
Furuta
Masao
M
Marumoto
Masao
M
Takemura
Hiroyasu
H
Ito
Mitsuru
M
Seishima
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D002908:Chronic Disease; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000145:classification / Q000175:diagnosis* / Q000652:urine; D008297:Male; D008875:Middle Aged; D011507:Proteinuria; D016482:Urinalysis / Q000379:methods*; D055815:Young Adult
D015415:Biomarkers; D003404:Creatinine