Dermal scatter reduction in human skin: a method using controlled application of glycerol.
OBJECTIVE
Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients.


METHODS
After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures.


CONCLUSIONS
Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light-based diagnostic or therapeutic devices.
BioTex, Inc., Houston, Texas 77054, USA.
Matthew A
MA
Fox
Dayna G
DG
Diven
Karen
K
Sra
Adam
A
Boretsky
Tasneem
T
Poonawalla
Allison
A
Readinger
Massoud
M
Motamedi
Roger J
RJ
McNichols
D000279:Administration, Cutaneous; D005990:Glycerol / Q000008:administration & dosage*; D006801:Humans; D028022:Low-Level Light Therapy / Q000379:methods*; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects*; D013653:Tattooing; D041623:Tomography, Optical Coherence
D005990:Glycerol