Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe, rare, and life-threatening adverse reactions to medications. Their incidence is approximately two patients per million population per year. Several cases have been reported in the literature in which SJS and TEN have occurred in patients with a neoplasm undergoing radiation therapy and who are taking an anticonvulsant. We report a case of SJS-TEN that developed in a 51-year-old woman with nonresectable non-small-cell lung cancer during treatment with phenobarbital plus radiation therapy for bone metastases but in whom the irradiated areas did not exhibit the SJS skin reaction. To our knowledge, no similar cases have been reported in the literature.
Department of Radiation Oncology, University Sapienza, via del Policlinico, 155 00161, Rome, Italy.
Daniela
D
Musio
Elisabetta
E
Parisi
Francesco
F
Dionisi
Giuseppe
G
Parisi
Rossella
R
Caiazzo
Nadia
N
Bulzonetti
Miriam
M
Lichtner
Nicola
N
Raffetto
Vincenzo
V
Vullo
Enzo
E
Banelli
D000927:Anticonvulsants / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008875:Middle Aged; D010634:Phenobarbital / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
D000927:Anticonvulsants; D010634:Phenobarbital