TB vaccines: current status and future perspectives.
Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Antigen discovery programs have exploited this and used proteome studies and T-cell recognition in PPD-positive individuals to select proteins and after testing for protective efficacy in animals the most promising proteins have been put together in fusion molecules. Three such fusion proteins are currently in clinical trials, the two most advanced have already passed phase I trials and are entering phase II.
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark.
Claus
C
Aagaard
Jes
J
Dietrich
Mark
M
Doherty
Peter
P
Andersen
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D002986:Clinical Trials as Topic; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D032581:Tuberculosis Vaccines / Q000276:immunology* / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control*
D000942:Antigens, Bacterial; D032581:Tuberculosis Vaccines