Polymeric micelles from poly(ethylene glycol)-poly(amino acid) block copolymer for drug and gene delivery.
Dramatic advances in biological research have revealed the mechanisms underlying many diseases at the molecular level. However, conventional techniques may be inadequate for direct application of this new knowledge to medical treatments. Nanobiotechnology, which integrates biology with the rapidly growing field of nanotechnology, has great potential to overcome many technical problems and lead to the development of effective therapies. The use of nanobiotechnology in drug delivery systems (DDS) is attractive for advanced treatment of conditions such as cancer and genetic diseases. In this review paper for a special issue on biomaterial research in Japan, we discuss the development of DDS based on polymeric micelles mainly in our group for anti-cancer drug and gene delivery, and also address our challenges associated with developing polymeric micelles as super-functionalized nanodevices with intelligent performance.
Osada
Kensuke
K
Department of Materials Engineering, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Christie
R James
RJ
Kataoka
Kazunori
K
D000596:Amino Acids / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004247:DNA / Q000737:chemistry; D016503:Drug Delivery Systems; D004355:Drug Stability; D015870:Gene Expression; D018014:Gene Transfer Techniques; D006801:Humans; D008823:Micelles; D036103:Nanotechnology; D010957:Plasmids / Q000235:genetics; D011092:Polyethylene Glycols / Q000737:chemistry*
D000596:Amino Acids; D000970:Antineoplastic Agents; D008823:Micelles; D011092:Polyethylene Glycols; D004247:DNA