[Application of multi-coeffieient of variation significance test for toxicology study].
OBJECTIVE
To establish the methods of calculating and analyzing the multi-coefficient of variation significance test for the toxicology study.


METHODS
The paper aimed to confirm the significance level with the method of Bonferroni and then compared the methods of calculating and analyzing of the experiment groups with the control group respectively.


RESULTS
The significance level of multi-coefficient of variation significance test was confirmed as alpha1=0.0167. Compared with the control groups, the activity of ALT in serum both in 30 mg/kg and 60 mg/kg groups did not change in the average significance test, which was not statistically significant (P>0.05), while it changed in the variation significance test, which was of statistical significance (P<0.0167). The activity of AST in serum in 60 mg/kg group did not change in the average significance test (P>0.05), while it changed in the variation significance test (P<0.0167).


CONCLUSIONS
The complete changes of the indexes can only be shown by use of both the average significance test and the variation significance test together.
Department of Preventive Medicine, Guilin Medical College, Guilin 541004, China.
Sheng-lian
SL
Li
Sheng-kui
SK
Tan
Wen-xiang
WX
Shi
Chao-yan
CY
Ou
Ming-shen
MS
Lu
Ya-dan
YD
Zheng
Hua
H
Luo
Xin-zhen
XZ
Qu
Cai-xia
CX
Guo
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D007855:Lead Poisoning / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar; D016008:Statistical Distributions
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase