Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance.
There is a growing number of case reports of hepatoxicity from the widely marketed weight-loss supplement Hydroxycut, which contains the botanical ingredient Garcinia cambogia. These case reports may substantially undercount the true magnitude of harm. Based on the past experience with harmful dietary supplements, US regulators should assume the more precautionary approach favored by Canada and Europe. Lacking effective adverse event surveillance for supplements, or the requirements to prove safety prior to coming to the market, case reports such as those summarized here assume added importance.
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Lobb
D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D019440:Anti-Obesity Agents / Q000009:adverse effects*; D019587:Dietary Supplements / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D040541:Marketing; D014481:United States; D014486:United States Food and Drug Administration; D015431:Weight Loss / Q000187:drug effects*; D055815:Young Adult
D019440:Anti-Obesity Agents