A collagen-mimic dendrimer capable of controlled release.
A collagen model peptide-attached dendrimer was synthesized as a potential functional collagen material. The peptides that clustered at the surface of the dendrimer formed a thermally reversible collagen-like triple helix. This dendrimer worked as a drug carrier with thermosensitive release capabilities, although it did not exhibit a lower critical solution temperature. From this dendrimer, the hydrogel could be made at low temperature.
Kojima
Chie
C
Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.
Tsumura
Sayako
S
Harada
Atsushi
A
Kono
Kenji
K
D002942:Circular Dichroism; D003094:Collagen / Q000138:chemical synthesis / Q000737:chemistry*; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D013499:Surface Properties; D013696:Temperature; D013997:Time Factors
D050091:Dendrimers; D004337:Drug Carriers; D010455:Peptides; D003094:Collagen