Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese Zucker (fa/fa) rats.
Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H(2)O(2)-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.
Wergedahl
Hege
H
Institute of Medicine, Section of Medical Biochemistry, University of Bergen, Haukeland University Hospital, Bergen, Norway. hege.wergedahl@med.uib.no
Berge
Kjetil
K
Bohov
Pavol
P
Tronstad
Karl-Johan
KJ
Madsen
Lise
L
Berge
Rolf K
RK
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D050556:Fatty Acid-Binding Proteins / Q000187:drug effects / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009765:Obesity / Q000188:drug therapy* / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects*; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker; D013440:Sulfides / Q000008:administration & dosage / Q000494:pharmacology*
D000975:Antioxidants; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D007328:Insulin; D012333:RNA, Messenger; D013440:Sulfides; D008315:Malondialdehyde; C062078:1-(carboxymethylthio)tetradecane; D006861:Hydrogen Peroxide