Feasibility and safety of longitudinal magnetic resonance imaging in a rodent model with intracortical microwire implants.
The purpose of this communication is to investigate (1) the feasibility of carrying out longitudinal magnetic resonance imaging (MRI) studies in animals with implanted microwire electrodes adapted for MRI compatibility, (2) the effect of MRI studies on the quality of neurophysiological recordings, (3) the use of MRI to study the extent and recovery of tissue damage due to electrode insertion and (4) histological tissue damage due to MRI. There was no evidence of chronic neural damage caused by repeated MRI by any of the measures used nor any statistical difference in the quality of the electrophysiological recordings between animals that had undergone MRI scans and those that had not.
Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA.
K J
KJ
Paralikar
T
T
Neuberger
J T
JT
Matsui
A J
AJ
Barber
A
A
Webb
R S
RS
Clement
D001930:Brain Injuries / Q000209:etiology* / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology / Q000528:radiation effects* / Q000601:surgery*; D004567:Electrodes, Implanted / Q000009:adverse effects*; D004869:Equipment Safety; D005240:Feasibility Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000009:adverse effects*; D023421:Models, Animal; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology