[Genetic markers of predisposition to infectious complications in neonatal infants with respiratory distress syndrome].
Neonatal respiratory distress syndrome (NRDS) is the commonest cause of death and morbidity of the newborn. A genetic risk for NRDS is currently recognized. The aim of this study was to determine whether there was an association of the polymorphisms of the SP-B, SP-D genes and the interleukins (IL)-1alpha, IL-10 genes with the development of infectious complications in neonatal infants with the respiratory distress syndrome. It was found that the certain genotypes by the polymorphic loci of surfactant proteins and interleukins might be associated with infectious diseases in the newborn with respiratory distress syndrome.
Bogdanova
R Z
RZ
Tsydenzhapov
E Ts
ETs
Fatykhova
A I
AI
Viktorov
V V
VV
Viktorova
T V
TV
Mironov
P I
PI
D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D016753:Interleukin-10 / Q000235:genetics; D053582:Interleukin-1alpha / Q000235:genetics; D008297:Male; D011014:Pneumonia / Q000209:etiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D037701:Pulmonary Surfactant-Associated Protein B / Q000235:genetics; D037663:Pulmonary Surfactant-Associated Protein D / Q000235:genetics; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications / Q000235:genetics*; D018805:Sepsis / Q000209:etiology / Q000235:genetics*
D005819:Genetic Markers; C508609:IL10 protein, human; D053582:Interleukin-1alpha; D037701:Pulmonary Surfactant-Associated Protein B; D037663:Pulmonary Surfactant-Associated Protein D; D016753:Interleukin-10