DNA condensation induced by ruthenium(II) polypyridyl complexes [Ru(bpy)(2)(PIPSH)](2+) and [Ru(bpy)(2)(PIPNH)](2+).
Two novel DNA-intercalating ruthenium(II) complexes, [Ru(bpy)(2)(PIPSH)](2+) and [Ru(bpy)(2)(PIPNH)](2+), have been synthesized and characterized. Gel retardation assay, atomic force microscopy, and dynamic light scattering studies show that both complexes can induce the condensation of originally circular plasmid pBR322 DNA to particulate structures under neutral conditions.
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China.
Bin
B
Sun
Jing-Xin
JX
Guan
Li
L
Xu
Bo-Le
BL
Yu
Long
L
Jiang
Jun-Feng
JF
Kou
Li
L
Wang
Xi-Dong
XD
Ding
Hui
H
Chao
Liang-Nian
LN
Ji
D004247:DNA / Q000737:chemistry*; D004587:Electrophoresis, Agar Gel; D008027:Light; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012542:Scattering, Radiation
D009942:Organometallic Compounds; C542258:bis(2,2'-bipyridine)(2-(4-benzoimidazolyl)phenylimidazo(4,5-f)(1,10)phenanthroline)ruthenium(II); C542257:bis(2,2'-bipyridine)(2-(4-benzothiazolyl)phenylimidazo(4,5-f)(1,10)phenanthroline)ruthenium(II); D004247:DNA