Multidetector row computed tomographic gastrography findings after endoscopic submucosal dissection for early gastric cancer: emphasis on time evolution and factors for predicting residual tumor.
OBJECTIVE
To retrospectively investigate multidetector row computed tomographic (CT) gastrography (CTG) findings after endoscopic submucosal dissection (ESD) of the stomach and to analyze the time evolution and factors for predicting residual tumor.


METHODS
During an 18-month period, ESD was performed for 92 early gastric cancers (EGCs) in 86 patients. All patients were followed up with CTG, and 6 patients underwent CTG 2times. A total of 98 CTGs were analyzed by 2 radiologists for the presence of mucosal break, overlying enhancing layer and the attenuation of the lesion on 2-dimensional (2D) images, and malignant-looking fold convergence on 3D volume-rendered images. Multidetector row computed tomographic gastrography findings were categorized into 5 types: deep benign ulcer (BU), deformed BU, shallow depressed ulcer, EGC, and advanced gastric cancer (AGC). To analyze the time evolution of CTG findings, the mean time interval between the procedure and CT was calculated and compared among the 5 types using the Kruskal-Wallis test. The chi test or Fisher exact test was used to determine significant CT findings for predicting residual tumor after ESD.


RESULTS
Tumor involvement was found at the resection margin in 7 lesions (6 radial and 1 deep). Of 98 lesions, 5 (5.1%) were not visualized on either 2D or 3D images. Most lesions had mucosal break (82/93) and showed intermediate low attenuation (67/93) on 2D images. Prominent enhancement of overlying layer above ESD site was seen in 23 lesions. Malignant-looking fold convergence was observed in 11 lesions. Sixty-five lesions appeared as shallow depressed ulcers, 13 as deformed BUs, 8 as EGCs, 4 AGCs, and 3 deep BUs. Among them, deep BUs appeared first (average, 0.2 month after ESD; P < 0.05), followed by deformed BUs (5.3 months), then AGCs (6.0 months), EGCs (7.3 months), and shallow depressed ulcers (7.7 months). However, the only significant time interval difference was between the deep BUs and the other types (P < 0.05). There was no correlation between the presence of marginal tumor involvement and any CT findings.


CONCLUSIONS
Immediately after ESD, lesions appear as deep BUs then evolve over time into shallow depressed ulcers. The presence of malignant-looking fold convergence and enhancing layer above the mucosal break on CT do not indicate tumor involvement at the ESD margin.
Lee
In Joon
IJ
Department of Radiology, Seoul National University Hospital, Seoul, Korea.
Kim
Se Hyung
SH
Lee
Jeong Min
JM
Kim
Sang Kyun
SK
Kim
Min A
MA
Han
Joon Koo
JK
Choi
Byung Ihn
BI
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042241:Early Diagnosis; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D014057:Tomography, X-Ray Computed / Q000379:methods*