Electrolytic lesions of the medial nucleus accumbens shell selectively decrease  ethanol consumption without altering preference in a limited access procedure  in C57BL/6J mice.
The central extended amygdala (cExtA) is a limbic region proposed to play a key role in drug and alcohol addiction and to contain the medial nucleus accumbens shell (MNAc shell). The aim of this study was to examine the involvement of the MNAc shell in ethanol and sucrose consumption in a limited and free access procedure in the C57BL/6J (B6) mouse. Separate groups of mice received bilateral electrolytic lesions of the MNAc shell or sham surgery, and following recovery from surgery, were allowed to voluntarily consume ethanol (15% v/v) in a 2 h limited access 2-bottle-choice procedure. Following 1 week of limited access ethanol consumption, mice were given 1 week of limited access sucrose consumption. A separate group of lesioned and sham mice were given free access (24 h) to ethanol in a 2-bottle choice procedure and were run in parallel to the mice receiving limited access consumption. Electrolytic lesions of the MNAc shell decreased ethanol (but not sucrose) consumption in a limited access procedure, but did not alter free access ethanol consumption. These results suggest that the MNAc shell is a component of the underlying neural circuitry contributing to limited access alcohol consumption in the B6 mouse.
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States. dhaherr@iupui.edu
Ronnie
R
Dhaher
Deborah A
DA
Finn
Denesa L
DL
Oberbeck
Naomi
N
Yoneyama
Christopher C
CC
Snelling
Weiran
W
Wu
Robert J
RJ
Hitzemann
D000818:Animals; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009714:Nucleus Accumbens / Q000473:pathology*
D000431:Ethanol