Escherichia coli O-157-induced hemolytic uremic syndrome: Usefulness of SCWP score for the prediction of neurological complication.
BACKGROUND
Hemolytic uremic syndrome (HUS) is commonly caused by hemorrhagic colitis with Shiga toxin-producing Escherichia coli O-157. Central nervous system (CNS) involvements, including seizures, encephalopathy and brain infarction, are serious complications, but there are no useful scores for the prediction of CNS complications.


METHODS
Routine laboratory data at onset of HUS were re-evaluated in 14 patients to find useful parameters for the prediction of CNS complication.


RESULTS
Serum sodium and total protein were significantly lower and C-reactive protein (CRP) and white blood cell counts were significantly higher in patients with CNS complications than in patients without. A cumulated score, SCWP score (sodium, CRP, white blood cell count, and total protein) discriminated better between patients with/without CNS complications than individual values.


CONCLUSIONS
SCWP score would be useful for prediction of CNS complications.
Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido, Gifu, Japan. t-tera@cc.gifu-u.ac.jp
Takahide
T
Teramoto
Toshiyuki
T
Fukao
Kouichiro
K
Hirayama
Tsutomu
T
Asano
Yusuke
Y
Aoki
Naomi
N
Kondo
D001798:Blood Proteins / Q000032:analysis*; D001927:Brain Diseases / Q000209:etiology*; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004927:Escherichia coli Infections / Q000150:complications / Q000382:microbiology; D019453:Escherichia coli O157; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications* / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D012964:Sodium / Q000097:blood*
D001798:Blood Proteins; D002097:C-Reactive Protein; D012964:Sodium