Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liability.
The inability to quantify the risk for disorders, such as substance use disorders (SUD), hinders etiology research and development of targeted intervention. Based on the concept of common transmissible liability to SUD related to illicit drugs, a method enabling quantification of this latent trait has been developed, utilizing high-risk design and item response theory. This study examined properties of a SUD transmissible liability index (TLI) derived using this method. Sons of males with or without SUD were studied longitudinally from preadolescence to young adulthood. The properties of TLI, including its psychometric characteristics, longitudinal risk assessment and ethnic variation, were examined. A pilot twin study was conducted to analyze the composition of TLI's phenotypic variance. The data suggest that TLI has concurrent, incremental, predictive and discriminant validity, as well as ethnic differences. The data suggest a high heritability of the index in males. The results suggest applicability of the method for genetic and other etiology-related research, and for evaluation of individual risk.
Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 711 Salk Hall, Pittsburgh, PA 15261, USA. mmv@pitt.edu
Michael M
MM
Vanyukov
Levent
L
Kirisci
Lisa
L
Moss
Ralph E
RE
Tarter
Maureen D
MD
Reynolds
Brion S
BS
Maher
Galina P
GP
Kirillova
Ty
T
Ridenour
Duncan B
DB
Clark
D000293:Adolescent; D000367:Age Factors; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology; D019970:Cocaine-Related Disorders / Q000235:genetics / Q000523:psychology; D004200:Diseases in Twins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D013287:Illicit Drugs; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D002189:Marijuana Abuse / Q000235:genetics / Q000523:psychology; D009293:Opioid-Related Disorders / Q000235:genetics / Q000523:psychology; D010641:Phenotype; D010865:Pilot Projects; D016016:Proportional Hazards Models; D012306:Risk; D012931:Social Environment; D019966:Substance-Related Disorders / Q000235:genetics* / Q000523:psychology; D014429:Twins, Dizygotic / Q000235:genetics / Q000523:psychology; D014430:Twins, Monozygotic / Q000235:genetics / Q000523:psychology; D055815:Young Adult
D013287:Illicit Drugs