Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents.
A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.
Francavilla
Charles
C
NovaBay Pharmaceuticals Inc., Emeryville, CA 94608, United States.
Low
Eddy
E
Nair
Satheesh
S
Kim
Bum
B
Shiau
Timothy P
TP
Debabov
Dmitri
D
Celeri
Chris
C
Alvarez
Nichole
N
Houchin
Ashley
A
Xu
Ping
P
Najafi
Ron
R
Jain
Rakesh
R
D000891:Anti-Infective Agents, Local / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002700:Chloramines / Q000138:chemical synthesis / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013451:Sulfonic Acids / Q000138:chemical synthesis / Q000737:chemistry
C541544:2-dichloroamino-2-methyl-propane-1-sulfonic acid sodium salt; D000891:Anti-Infective Agents, Local; D002700:Chloramines; D000644:Quaternary Ammonium Compounds; D013438:Sulfhydryl Compounds; D013451:Sulfonic Acids