A perfect double role of CF3 groups in activating substrates and stabilizing adducts: the chiral Brønsted acid-catalyzed direct arylation of trifluoromethyl ketones.
A direct and efficient Brønsted acid-promoted arylation of tri- and difluoromethyl ketones, as well perfluoroalkyl ketones, has been developed; good to excellent enantioselectivities (up to 99% ee) were achieved.
Department of Chemistry, Tianjin University, Tianjin 300072, China.
Jing
J
Nie
Guang-Wu
GW
Zhang
Lian
L
Wang
Aiping
A
Fu
Yan
Y
Zheng
Jun-An
JA
Ma
D000143:Acids / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D017611:Fluorine Compounds / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013379:Substrate Specificity
D000143:Acids; D017611:Fluorine Compounds; D007659:Ketones; D002244:Carbon