A new synthesis of caged GABA compounds for studying GABAA receptors.
A short and convergent synthetic approach to new photoactivatable precursors of gamma-aminobutyric acid (GABA) is described. When photolyzed, the 'caged' GABA precursor efficiently releases GABA, as judged by depolarization measurements on the mammalian GABA(A) receptor.
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853-1301, USA.
Lijun
L
Fan
Ryan W
RW
Lewis
George P
GP
Hess
Bruce
B
Ganem
D002460:Cell Line; D004566:Electrodes; D004594:Electrophysiology; D058787:GABA-A Receptor Antagonists; D006801:Humans; D018377:Neurotransmitter Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D058787:GABA-A Receptor Antagonists; D018377:Neurotransmitter Agents; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid