Pathogen recognition by innate immunity and its signaling.
Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan. sakira@biken.osaka-u.ac.jp
Shizuo
S
Akira
D000818:Animals; D000917:Antibody Formation; D017951:Antigen Presentation / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007111:Immunity, Cellular; D007113:Immunity, Innate; D009369:Neoplasms / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology
D016207:Cytokines; D051193:Toll-Like Receptors