[Acute immuno-allergic interstitial nephritis after treatment with fluindione. Seven cases].
We report seven cases of patients treated with fluindione, who presented with acute renal failure, associated with clinical features of allergy: poor status, fever, dyspnea, lymphadenopathy and erythroderma. All patients had elevated eosinophil counts. Renal biopsy disclosed in all cases a tubulo-interstitial nephritis with or without granuloma. The responsibility of fluindione, an oral anticoagulant widely used in France could be demonstrated. To our knowledge, there are only three reports of single cases of acute renal failure related to fluindione published so far to date. This serious side effect of fluindione should be recognized.
Reynaud
Franck
F
Centre hospitalier de Bigorre-Tarbes, service d'hémodialyse, boulevard de Maréchal-de-Lattre-de-Tassigny, 65013 Tarbes cedex 9, France. freynaud@ch-tarbes-vic.fr
Giraud
Patrick
P
Cisterne
Jean-Marc
JM
Verdier
Daniel
D
Kouchakipour
Zeinab
Z
Hermelin
Alain
A
Modesto-Segonds
Anne
A
Bagheri
Haleh
H
Pourrat
Jacques
J
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology*; D010630:Phenindione / Q000009:adverse effects / Q000031:analogs & derivatives*
D000925:Anticoagulants; D010630:Phenindione; C017673:fluindione