The structure of Cryptococcus neoformans galactoxylomannan contains beta-D-glucuronic acid.
The structure of galactoxylomannan, a capsular polysaccharide from the opportunistic yeast Cryptococcus neoformans, was re-examined by NMR spectroscopy and GC-MS. The residue that is 3-linked to the side chain galactose and was previously assigned as beta-D-xylose [Vaishnav, V. V.; Bacon, B. E.; O'Neill, M.; Cherniak, R. Carbohydr. Res.1998, 306, 315-330] was determined to be beta-D-glucuronic acid. A revised structure for this polymer is presented, along with a proposal that this compound be termed glucuronoxylomannogalactan (GXMGal).
Analytical Services/Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA. cheiss@ccrc.uga.edu
Christian
C
Heiss
J Stacey
JS
Klutts
Zhirui
Z
Wang
Tamara L
TL
Doering
Parastoo
P
Azadi
D002240:Carbohydrate Sequence; D003455:Cryptococcus neoformans / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011134:Polysaccharides / Q000737:chemistry*
D011134:Polysaccharides