Fighting the flu with inflammasome signaling.
A wide variety of stimuli induce the inflammasome, but little is known about its role in immune protection against viruses. In this issue of Immunity, Allen et al. (2009) and Thomas et al. (2009) describe a critical role for NLRP3 induction of the inflammasome and protection against influenza virus infection.
Owen
David M
DM
Department of Immunology, University of Washington, Seattle, WA 98195, USA.
Gale
Michael
M
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology*; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D009504:Neutrophils / Q000276:immunology; D015398:Signal Transduction
D002352:Carrier Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human