Effects of an ultraviolet B radiation absorber on photocarcinogenesis in hairless albino mice.
Uvinul T 150, a UVB absorber, was administered (concentration 5%) in a vehicle to the skin of hairless albino mice before ultraviolet radiation (UVR) exposure for 5 days per week in a photocarcinogenicity study. Uvinul T 150 prolonged the latency period to 50% skin tumor incidence (controls: 21-22 weeks; Uvinul T 150: 36 weeks in males and 31 weeks in females). When Uvinul T 150 was applied in an alternating-exposure procedure (3 days/week before and 2 days/week after UVR), the inhibition of photocarcinogenesis was less marked (latency period 28-30 weeks). The vehicle formulation had no effect (latency period 20-21 weeks). The sensitivity of the test system was demonstrated by a positive control (8-methoxy-psoralene). Although UVB absorption was shown to inhibit photocarcinogenesis, the results also suggest that UVA radiation makes a contribution to skin tumor formation.
Experimental Toxicology and Ecology, BASF, Ludwigshafen, Germany.
G
G
Coelho Palermo Cunha
B
B
van Ravenzwaay
H A
HA
Tennekes
W
W
Mellert
S
S
Schulte
S
S
Burkhardt
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D008730:Methoxsalen / Q000633:toxicity; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000517:prevention & control*; D009930:Organic Chemicals / Q000627:therapeutic use; D014677:Pharmaceutical Vehicles; D017319:Photosensitizing Agents / Q000633:toxicity; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D012867:Skin / Q000473:pathology / Q000528:radiation effects; D012883:Skin Ulcer / Q000473:pathology; D016019:Survival Analysis; D014466:Ultraviolet Rays
D009930:Organic Chemicals; D014677:Pharmaceutical Vehicles; D017319:Photosensitizing Agents; D011837:Radiation-Protective Agents; C059256:Uvinul T 150; D008730:Methoxsalen