Effectiveness of mycotoxin sequestration activity of micronized wheat fibres on distribution of ochratoxin A in plasma, liver and kidney of piglets fed a naturally contaminated diet.
A study was carried out to determine the ability of dietary micronized wheat fibres (MWF) to decrease the levels of ochratoxin A (OTA) in plasma, kidney and liver of piglets fed a naturally contaminated diet. A total of 96 piglets (weighting 11.4+/-1.5 kg) were fed one of four different diets for 28 days. Diets included (1) control diet, (2) control diet with MWF (1%), (3) OTA naturally contaminated diet (117.45+/-4.74 ng/g), (4) OTA naturally contaminated diet (118.13+/-2.85 ng/g) with MWF (1%). No difference in feed efficiency (P>0.05) could be observed between the different diets. The absolute weight of kidneys and liver were significantly higher in pigs fed the OTA-contaminated diet (diet 3) as compared to the control diet (diet 1) or to the control diet amended with MWF (diet 2) (P<0.05). However the use of MWF (diet 4) significantly protected against these weight changes. A significant protective effect of MWF was also observed in terms of OTA concentration in plasma (45.6% decrease), kidney (40.8% decrease) and liver (26.5% decrease). These results suggest that the addition of MWF is effective in decreasing the bioavailability of OTA from contaminated diets in piglets.
Aoudia
N
N
Unité de Biochimie de la Nutrition, Faculté d'Ingénierie Biologique, Agronomique et Environnementale, Croix du sud 8/02, Université Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium.
Callu
P
P
Grosjean
F
F
Larondelle
Y
Y
D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002273:Carcinogens / Q000493:pharmacokinetics*; D002846:Chromatography, Affinity; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology*; D005260:Female; D005506:Food Contamination / Q000032:analysis; D006128:Growth / Q000187:drug effects; D007120:Immunochemistry; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009183:Mycotoxins / Q000378:metabolism*; D009793:Ochratoxins / Q000097:blood / Q000493:pharmacokinetics*; D009929:Organ Size / Q000187:drug effects; D013552:Swine; D014018:Tissue Distribution; D014908:Triticum / Q000737:chemistry*
D002273:Carcinogens; D004043:Dietary Fiber; D009183:Mycotoxins; D009793:Ochratoxins; C025589:ochratoxin A