Efficient catalytic promiscuity for chemically distinct reactions.
High catalytic proficiencies observed for the native and promiscuous reaction of the Pseudomonas aeruginosa arylsulfatase (PAS; the picture shows transition states of the two substrates with corresponding binding constants K(tx)) suggest that the trade-off between high activity and tight specificity can be substantially relaxed.
Babtie
Ann C
AC
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Bandyopadhyay
Subhajit
S
Olguin
Luis F
LF
Hollfelder
Florian
F
D001192:Arylsulfatases / Q000737:chemistry* / Q000235:genetics; D055162:Biocatalysis; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000201:enzymology*; D013379:Substrate Specificity
D001192:Arylsulfatases