Cohesin acetylation: from antiestablishment to establishment.
In a recent issue of Molecular Cell, Rowland et al. (2009) report that acetylation of cohesin in S phase transiently counteracts an intrinsic "antiestablishment" activity and, thus, enables establishment of sister chromatid cohesion.
Peters
Jan-Michael
JM
Research Institute of Molecular Pathology, Vienna, Austria. peters@imp.ac.at
Bhaskara
Venugopal
V
D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D011508:Chondroitin Sulfate Proteoglycans / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D002842:Chromatids / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D016196:S Phase / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000097722:Cohesins
D000123:Acetyltransferases; D018797:Cell Cycle Proteins; D011508:Chondroitin Sulfate Proteoglycans; D002868:Chromosomal Proteins, Non-Histone; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D000097722:Cohesins; C427726:PDS5 protein, S cerevisiae; C120372:SMC3 protein, S cerevisiae; C118076:ECO1 protein, S cerevisiae