Four spatial points that define enzyme families.
The catalytic properties of enzymes, containing the Asp-His-Ser triads are deeply investigated for a long time. Serine endopeptidases, cutinases, acetylcholinesterases, cellulases, among other enzymes, contain these triads. We found that solely the geometric properties of just four points in the spatial structure of these enzymes are characteristic to their family.
Protein Information Technology Group, Eötvös University, 1117 Budapest, Hungary.
Gábor
G
Iván
Zoltán
Z
Szabadka
Rafael
R
Ordög
Vince
V
Grolmusz
Gábor
G
Náray-Szabó
D000595:Amino Acid Sequence; D001224:Aspartic Acid / Q000737:chemistry*; D002384:Catalysis; D030562:Databases, Protein; D004798:Enzymes / Q000737:chemistry* / Q000145:classification*; D006639:Histidine / Q000737:chemistry*; D011487:Protein Conformation; D012694:Serine / Q000737:chemistry*
D004798:Enzymes; D001224:Aspartic Acid; D012694:Serine; D006639:Histidine