Myasthenia gravis associated with etanercept therapy.
Etanercept is an antagonist of tumor necrosis factor alpha that was developed to treat rheumatoid arthritis. In this report we present a patient who developed myasthenia gravis while taking etanercept and had resolution of symptoms after stopping it. This is the first report of this potential side effect and is of additional interest, because etanercept has been proposed as a treatment for myasthenia gravis.
Fee
Dominic B
DB
Department of Neurology, University of Kentucky Chandler Medical Center, KY Clinic, Room L-445, Lexington, Kentucky 40536-0284, USA. dbfee2@email.uky.edu
Kasarskis
Edward J
EJ
D000368:Aged; D018501:Antirheumatic Agents / Q000008:administration & dosage; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D001323:Autoantibodies / Q000097:blood / Q000187:drug effects; D003680:Deglutition Disorders / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology; D000068800:Etanercept; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D010614:Pharynx / Q000187:drug effects / Q000503:physiopathology; D020794:Receptor Protein-Tyrosine Kinases / Q000187:drug effects / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism
D018501:Antirheumatic Agents; D001323:Autoantibodies; D007074:Immunoglobulin G; D011950:Receptors, Cholinergic; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases; D000068800:Etanercept