Targeting DNA topoisomerase II in cancer chemotherapy.
Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including DNA replication, transcription and chromosome segregation. Although the biological functions of TOP2 are important for ensuring genomic integrity, the ability to interfere with TOP2 and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. The molecular tools that have allowed an understanding of the biological functions of TOP2 are also being applied to understanding the details of drug action. These studies promise refined targeting of TOP2 as an effective anticancer strategy.
Nitiss
John L
JL
Molecular Pharmacology Department, St Jude Children's Research Hospital, Memphis, TN 38105, USA. john.nitiss@stjude.org
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002384:Catalysis; D004247:DNA / Q000378:metabolism; D004260:DNA Repair; D004250:DNA Topoisomerases, Type II / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D059005:Topoisomerase II Inhibitors
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D059005:Topoisomerase II Inhibitors; D004247:DNA; D004250:DNA Topoisomerases, Type II