[Change of cartilage matrix metabolism under stress].
With the effects of the mechanics and biological factors, the imbalance between the degradation and synthesis of chondrocyte, extracelluar matrix and subchondral bone leads to the osteoarthritis. The imbalance between MMPs and TIMPs caused by biomechanical abnormality is the key factor of osteoarthritis. This review will focus on the stress and their roles in the metabolism of the cartilage matrix.
Shao
Yue-feng
YF
Department of Orthopaedics, the Second Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi, China.
Wei
Xiao-chun
XC
D002356:Cartilage / Q000378:metabolism*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D010003:Osteoarthritis / Q000378:metabolism; D013314:Stress, Mechanical; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism*
D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases