Combinatorial chemistry in the agrosciences.
Combinatorial chemistry and high throughput screening have had a profound effect upon the way in which agrochemical companies conduct their lead discovery research. The article reviews recent applications of combinatorial synthesis in the lead discovery process for new fungicides, herbicides and insecticides. The role and importance of bioavailability guidelines, natural products, privileged structures, virtual screening and X-ray crystallographic protein structures on the design of solid- and solution-phase compound libraries is discussed and illustrated.
Lindell
Stephen D
SD
Bayer CropScience AG, Werk Höchst, G836, D-65926 Frankfurt am Main, Germany. stephen.lindell@bayercropscience.com
Pattenden
Lisa C
LC
Shannon
Jonathan
J
D016573:Agrochemicals / Q000138:chemical synthesis / Q000737:chemistry*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry; D001682:Biological Availability; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D017076:Computer-Aided Design; D006540:Herbicides / Q000138:chemical synthesis / Q000737:chemistry; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry; D054852:Small Molecule Libraries; D013329:Structure-Activity Relationship
D016573:Agrochemicals; D000935:Antifungal Agents; D006540:Herbicides; D007306:Insecticides; D054852:Small Molecule Libraries