Differential representation of spectral and temporal information by primary auditory cortex neurons in awake cats: relevance to auditory scene analysis.
We investigated how the primary auditory cortex (AI) neurons encode the two major requisites for auditory scene analysis, i.e., spectral and temporal information. Single-unit activities in awake cats AI were studied by presenting 0.5-s-long tone bursts and click trains. First of all, the neurons (n=92) were classified into 3 types based on the time-course of excitatory responses to tone bursts: 1) phasic cells (P-cells; 26%), giving only transient responses; 2) tonic cells (T-cells; 34%), giving sustained responses with little or no adaptation; and 3) phasic-tonic cells (PT-cells; 40%), giving sustained responses with some tendency of adaptation. Other tone-response variables differed among cell types. For example, P-cells showed the shortest latency and smallest spiking jitter while T-cells had the sharpest frequency tuning. PT-cells generally fell in the intermediate between the two extremes. Click trains also revealed between-neuron-type differences for the emergent probability of excitatory responses (P-cells>PT-cells>T-cells) and their temporal features. For example, a substantial fraction of P-cells conducted stimulus-locking responses, but none of the T-cells did. f(r)-dependency characteristics of the stimulus locking resembled that reported for "comodulation masking release," a behavioral model of auditory scene analysis. Each type neurons were omnipresent throughout the AI and none of them showed intrinsic oscillation. These findings suggest that: 1) T-cells preferentially encode spectral information with a rate-place code and 2) P-cells preferentially encode acoustic transients with a temporal code whereby rate-place coded information is potentially bound for scene analysis.
Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan. msakai@yamanashi.ac.jp
Masashi
M
Sakai
Sohei
S
Chimoto
Ling
L
Qin
Yu
Y
Sato
D000161:Acoustic Stimulation; D000200:Action Potentials; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D002415:Cats; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*; D013995:Time; D013998:Time Perception / Q000502:physiology*