[The effect of two different oral antiseptics on dental plaque formation (de novo biofilm) and on gingival inflammation].
BACKGROUND
Since the discovery that periodontal diseases are caused by microbial plaque the interest of many scientists has been focused on oral antiseptics. There are very few mouthrinses with oral antiseptic effect originally designed in our country. One of these is Ozosept solution.


OBJECTIVE
This study evaluated the effect of Ozosept solution (phenol compound) on the oral hygiene and gingival inflammation, in comparison with Hibidex DAP solution (chlorhexidine digluconate).


METHODS
Two groups, each of 21 persons, which did not significantly differ concerning Silness-Löe plaque index (PI) and Löe-Sillnes gingival index (GI), used one of the studied oral antiseptic for a 15-day period. Oral hygiene was maintained by subjects' habitual home methods, and no technique of professionally advised brushing was performed during the experimental period.


RESULTS
At the end of the study, PI and GI scores were lowered to a statistically high significance in both groups of participants in comparison to the indexes at the beginning of the study. At the end of the study, PI and GI scores did not significantly differ between the two analyzed groups. No side effects, which were recorded in the Hibidex DAP group (tooth and filling staining 9.5% and 4.74% respectively, transitory tongue numbness 28.6% and reduced taste sensation 14.3%), were registered in the group of subjects using Ozosept solution.


CONCLUSIONS
It is concluded that Ozosept solution is effective in the control of dental plaque--biofilm accumulation and gingival inflammation, and produces no side effects related to chlorhexidine digluconate usage.
Zelić
Obrad
O
Cakić
Sasa
S
Luković
Natalija
N
D000328:Adult; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000494:pharmacology*; D019800:Phenol / Q000494:pharmacology*
D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D019800:Phenol; C010882:chlorhexidine gluconate; D002710:Chlorhexidine