Clinical applications of N-terminal pro B-type natriuretic peptide in heart failure and other cardiovascular diseases.
N-terminal fragment of pro B-type natriuretic peptide (NT-proBNP) has emerged as an important adjunct in the management of heart failure (HF) and other cardiovascular diseases. NT-proBNP is a 76-amino acid peptide created during cleavage of the precursor molecule, Pro B-type natriuretic peptide (ProBNP). NT-proBNP is of significant diagnostic value in patients presenting with possible HF and is an important prognostic factor in this condition and other cardiovascular diseases. Ongoing research supports the potential value of this biomarker in non-cardiovascular disease. This review will describe clinical applications of NT-proBNP in HF and a broad range of other conditions.
Department of Ultrasonography, The Second Xiangya Hospital of Central South University, Renming, Changsha, People's Republic of China.
Da-Rong
DR
Pu
Jun R
JR
Chiong
Qi-chang
QC
Zhou
D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000473:pathology; D003324:Coronary Artery Disease / Q000473:pathology; D003971:Diastole; D004417:Dyspnea; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology; D020097:Natriuretic Peptide, Brain; D010446:Peptide Fragments; D016491:Peripheral Vascular Diseases / Q000473:pathology; D011379:Prognosis; D016277:Ventricular Function, Left
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain