Deficiency of growth hormone in an adult man case of idiopathic adrenocorticotropin deficiency.
Growth hormone (GH) deficiency is transient in most cases of adrenocorticotropin (ACTH) deficiency, while deficiency of both selective ACTH and GH in adults, as in the present case, is rare among hypopituitarism cases. In this patient, one year after hydrocortisone replacement for ACTH deficiency, data on GH secretion by insulin tolerance test and GH-releasing peptide-2 injection showed a partial improvement, but still there was lack of an adequate response. We consider that the patient had the deficiency of both selective GH and ACTH. Therefore, careful monitoring of GH function after the glucocorticoid replacement is required in cases of ACTH deficiency.
Kageyama
Kazunori
K
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. kkageyama@hkg.odn.ne.jp
Tsushima
Yuko
Y
Tomotsune
Ken
K
Yanagimachi
Miyuki
M
Sakihara
Satoru
S
Suda
Toshihiro
T
D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D005938:Glucocorticoids / Q000627:therapeutic use; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007018:Hypopituitarism / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone