MRI--the perfect surrogate marker for multiple sclerosis?
MRI provides a very sensitive reflection of the histopathological changes in multiple sclerosis. Many short-term studies fail to appreciate the relationship between MRI and clinical findings, although such shortcomings might be argued to reflect a weakness of clinical measures, rather than of MRI.
MS Center Amsterdam and Department of Radiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. f.barkhof@vumc.nl
Frederik
F
Barkhof
Massimo
M
Filippi
D001921:Brain / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology