Sucutiniranes C-F, cassane-type diterpenes from Bowdichia nitida.
Four new cassane-type diterpenes, sucutiniranes C-F (3-6), have been isolated from seeds of Bowdichia nitida, and their structures were elucidated by using 2D NMR data, chemical correlations, and X-ray analysis. Sucutiniranes E (5) and F (6) were moderately cytotoxic against human blood premyelocytic leukemia (HL-60), breast adenocarcinoma (MCF-7), and colon cancer (HCT-116) cells.
Matsuno
Yosuke
Y
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
Deguchi
Jun
J
Hosoya
Takahiro
T
Hirasawa
Yusuke
Y
Hirobe
Chieko
C
Shiro
Motoo
M
Morita
Hiroshi
H
D000972:Antineoplastic Agents, Phytogenic / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D045325:HCT116 Cells; D018922:HL-60 Cells; D006801:Humans; D007564:Japan; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes