Central retinal vein occlusion secondary to clomiphene treatment in a male carrier of factor V Leiden.
We report a case of a 35-year-old previously healthy man treated with clomiphene for infertility, who presented with blurred vision in his left eye due to ocular vein occlusion as documented by fluorescein angiography. The patient was heterozygous for the factor V Leiden (FV Leiden) mutation and for the 1298 A-C polymorphism of the methylene-tetrahydrofolate reductase (MTHFR) gene. He was treated with clopidogrel and is now free of symptoms. Because congenital thrombophilia is a moderate risk factor for central retinal vein occlusion and the administration of clomiphene may trigger this process, we recommend screening of young patients for FV Leiden before clomiphene treatment.
Marianna
M
Politou
Argyri
A
Gialeraki
Efrossyni
E
Merkouri
Anthi
A
Travlou
Stefanos
S
Baltatzis
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use; D000077144:Clopidogrel; D005123:Eye / Q000098:blood supply*; D005165:Factor V / Q000235:genetics*; D005451:Fluorescein Angiography; D006579:Heterozygote; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy; D008297:Male; D009154:Mutation; D012170:Retinal Vein Occlusion / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D016896:Treatment Outcome
C095381:factor V Leiden; D002996:Clomiphene; D005165:Factor V; D000077144:Clopidogrel; D013988:Ticlopidine