[A case of IL-6 producing malignant mesothelioma of abdomen with thrombocytosis].
A 77-year-old man was admitted to our hospital with abdominal pain and ascites. He had an occupational history of working with asbestos. Abdominal CT showed multiple nodular lesions with enhancement by contrast medium in the cavity. Platelet counts, CRP and serum IL-6 level were increased. Biopsied materials obtained by laparoscopy showed oval cells with rich cytoplasm growing in an epithelial pattern. To clarify the characteristics of the cells, immunohistochemistry was performed. Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma. Because IL-6, IL-6 receptor and VEGF were expressed markedly, the patient received chemotherapy for IL-6 suppression. During the treatment, thrombocytosis imploved satisfactorily.
Department of Gastroenterology, Kanazawa Medical University, Japan. t-fukky@kanazawa-med.ac.jp
Tomoki
T
Fukuyama
Hiromu
H
Kawahara
Masayoshi
M
Yamada
Nobuhiko
N
Hayashi
Hirokazu
H
Yano
Masayuki
M
Fukura
Kazuaki
K
Ozaki
Mutsumi
M
Tsuchishima
Shujiro
S
Takase
Tomiyasu
T
Arisawa
Kazuhiko
K
Omote
Takayuki
T
Nojima
D000008:Abdominal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D000368:Aged; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D008654:Mesothelioma / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D013922:Thrombocytosis / Q000150:complications
D015850:Interleukin-6