Capsid (CA) protein as a novel drug target: recent progress in the research of HIV-1 CA inhibitors.
The capsid (CA) protein is the major structural component of HIV-1 and plays a key role in the regulation of viral life cycle. Inhibition of CA will affect the viral assembly and budding processes, causing decreased viral infectivity. This review describes the structure and function of the HIV-1 CA and latest progress in the discovery of HIV-1 CA inhibitors.
Zhang
Jiyan
J
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012 PR China. zhangjiyan@163.com
Liu
Xinyong
X
De Clercq
Erik
E
D000818:Animals; D036022:Capsid Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D016503:Drug Delivery Systems; D015497:HIV-1 / Q000737:chemistry*; D006801:Humans; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000502:physiology
D036022:Capsid Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus