Is hepcidin the star player in iron metabolism in chronic kidney disease?
It is well known that abnormal iron metabolism contributes to the development of anemia in chronic kidney disease (CKD) patients. Hepcidin is a circulating peptide produced in the liver that regulates efflux of iron from the cells. Ashby et al. measured the serum level of hepcidin using a new assay. Although the new assay produced mixed results and needs to be verified, these data suggest that hepcidin is not the only star player in iron metabolism in CKD.
Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan.
Yasuhiro
Y
Hamada
Masafumi
M
Fukagawa
D000740:Anemia / Q000209:etiology; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D064451:Hepcidins; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism*
D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D007501:Iron