Epstein-Barr virus associated primary intracranial leiomyoma in organ transplant recipient: case report and review of the literature.
BACKGROUND
A 45 year old female renal transplant recipient presented with headaches of 3 months duration. Clinical and radiological evaluation revealed an approximately 4x4 cm rounded, enhancing mass at the left temporal pole. At surgery, the mass had dural attachment and clinically, radiographically, and macroscopically resembled a meningioma. Histopathological analysis revealed a leiomyoma. Epstein-Barr virus (EBV) DNA was demonstrated within the tumour cell nuclei by the in situ hybridisation technique.


CONCLUSIONS
This is the first documentation of an EBV-associated primary intracranial leiomyoma in an organ transplant recipient and provides additional evidence of a possible relation between EBV infection and development of smooth-muscle tumours (SMT).


CONCLUSIONS
With increasing numbers of individuals being on long-term immuno-suppression, EBV-associated SMTs may be encountered more frequently in the future.
Zevgaridis
Dimitris
D
Department of Neurosurgery, Medical School of Aristotle University, Hippokration General Hospital, Thessaloniki, Greece. zevgarid@hol.gr
Tsonidis
Christos
C
Kapranos
Nikiforos
N
Venizelos
Ioannis
I
Tsitsopoulos
Parmenion
P
Tsitsopoulos
Philippos
P
D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology*; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007889:Leiomyoma / Q000473:pathology* / Q000601:surgery / Q000821:virology*; D008875:Middle Aged; D019635:Neurosurgical Procedures; D016377:Organ Transplantation; D016896:Treatment Outcome
D007166:Immunosuppressive Agents