Lactones from Angiopteris caudatiformis.
Angiopterlactones A (1) and B (2), two unique lactones, and three known lactones, osmundalactone (3), osmundalin (4), and 3,5-dihydroxy-gamma-caprolactone (5), have been isolated from the rhizome of Angiopteris caudatiformis. The structures of 1 and 2 were determined by NMR and MS methods, and the structure of 2 was confirmed by X-ray crystallography. The absolute configurations of 1 and 2 were assigned by application of the CD excitation chirality method and the modified Mosher's method. Compound 1 was slightly cytotoxic against HeLa cells, with an IC(50) value of 68.8 microM, and compounds 3 and 4 showed moderate insect antifeeding activity against Plutella xylostella and Heliothis virescens.
Yu
Yong-Ming
YM
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.
Yang
Jun-Shan
JS
Peng
Chao-Zhong
CZ
Caer
Valerie
V
Cong
Pu-Zhu
PZ
Zou
Zhong-Mei
ZM
Lu
Yang
Y
Yang
Shi-Ying
SY
Gu
Yu-Cheng
YC
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005247:Feeding Behavior / Q000187:drug effects; D029624:Ferns / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects; D027343:Rhizome / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; C550872:angiopterlactone A; C550873:angiopterlactone B