Slow release antibiotics for treatment of septic arthritis in large animals.
The search for an effective treatment for septic arthritis is ongoing. Current therapies are expensive since they require repeated joint lavage and long term antibiotic treatment. Local application of antimicrobial drugs is advantageous because high concentrations can be attained at the infection site, although repeated injections increase the risk of superinfection of the joint. Thus, slow release formulations, which have the advantage of local treatment yet single application of the drug, are appealing. Antibiotics used in slow release formulations are selected for tissue compatibility, an appropriate antibacterial spectrum, and stability both during the mixing procedure and within the carrier during the release period. Ideally the carriers should be bioresorbable. Promising reports on the clinical use of poly(methyl methacrylate) (PMMA) mixed with several different antibiotics, and of collagen sponges impregnated with gentamicin, should encourage the search for formulations optimally adapted to veterinary medical requirements.
Institute of Animal Sciences, Physiology and Behaviour, ETH Zurich, CH-8092 Zurich, Switzerland. christina-haerdi@ethz.ch
M Christina
MC
Haerdi-Landerer
Judith
J
Habermacher
Barbara
B
Wenger
Maja M
MM
Suter
Adrian
A
Steiner
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy; D003094:Collagen; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000627:therapeutic use; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006734:Horse Diseases / Q000188:drug therapy; D006736:Horses; D008768:Methylmethacrylates; D014677:Pharmaceutical Vehicles / Q000627:therapeutic use; D019904:Polymethyl Methacrylate / Q000627:therapeutic use; D015503:Surgical Sponges; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D005839:Gentamicins; D008768:Methylmethacrylates; D014677:Pharmaceutical Vehicles; C030159:gentamicin-polymethylmethacrylate bead; D003094:Collagen; D019904:Polymethyl Methacrylate