Interstitial pneumonitis associated with infliximab therapy without methotrexate treatment.
Tumor necrosis factor (TNF)-α inhibitors are increasingly being used to treat rheumatoid arthritis. Infliximab (INF) is a TNF-α inhibitor that is usually used in combination with methotrexate (MTX). Interstitial lung disease (ILD) during combination therapy has been attributed to MTX rather than INF. However, INF-associated ILD without combination with MTX has recently been reported. We describe herein a case of severe ILD secondary to INF without MTX therapy.
First Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. htaki-tym@umin.ac.jp
Hirofumi
H
Taki
Yukio
Y
Kawagishi
Koichiro
K
Shinoda
Hiroyuki
H
Hounoki
Reina
R
Ogawa
Eiji
E
Sugiyama
Kazuyuki
K
Tobe
D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001379:Azathioprine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000069285:Infliximab; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000209:etiology*; D008727:Methotrexate / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D018396:Mucin-1 / Q000097:blood; D011859:Radiography; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; C060192:MUC1 protein, human; D018396:Mucin-1; D000069285:Infliximab; D001379:Azathioprine; D008775:Methylprednisolone; D008727:Methotrexate