[Papillary thyroid carcinoma of an interventional cardiologist. A case report].
A 52-year old female cardiologist with 16 year radiation exposure in Cath Lab as an interventional cardiologist developed a multifocal papillary thyroid carcinoma. Dosimetric (below apron) cumulative exposure totalled 56 mSv, corresponding to 2,800 chest radiographs. The patient also carried genetic polymorphisms of genes (XRCC1 and XRCC3) involved in DNA repair, increasing the cancer risk after ionizing radiation exposure. Dose optimization and diligent radioprotection are essential to minimize cancer risk in professionally exposed cardiologist. Good dosimetric practice is essential to establish a legally plausible cause-effect relationship between exposure and damage.
Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa.
Lucia
L
Venneri
Ilenia
I
Foffa
Rosa
R
Sicari
D002291:Carcinoma, Papillary / Q000209:etiology* / Q000235:genetics; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000235:genetics; D016273:Occupational Exposure / Q000009:adverse effects*; D010820:Physicians; D011110:Polymorphism, Genetic; D011829:Radiation Dosage; D015642:Radiology, Interventional; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000235:genetics; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C110901:X-ray repair cross complementing protein 3; C000619371:XRCC1 protein, human