Dopamine D3 receptor gene polymorphism influences on behavioral and psychological symptoms of dementia (BPSD) in mild dementia of Alzheimer's type.
Dopamine D3 receptor (DRD3) is present in the limbic system, which is thought to regulate affect, cognition, and activity. Thus a functional change in the DRD3 gene could in turn affect the cognitive and psychiatric symptoms of dementia of Alzheimer's type (DAT). We investigated a possible association of DRD3 genotype with DAT and the behavioral and psychological symptoms of dementia (BPSD) in mild DAT. The genotyping for DRD3 and apolipoprotein E (ApoE) was determined using restriction fragment length polymorphism in 210 patients with mild DAT and 224 age- and sex-matched non-demented controls. The occurrence of BPSD during the course of mild dementia was demonstrated using the Behavioral Pathology in Alzheimer's Disease rating scale (BEHAVE-AD). No significant differences in DRD3 genotype were identified between DAT and controls, regardless of ApoE epsilon4. Among the DAT with BPSD, however, a significant association was observed between the presence of the DRD3 glycine allele and paranoid and delusional ideation, regardless of ApoE epsilon4. In conclusion, DRD3 gene polymorphism is unlikely to play a substantial role in conferring susceptibility to DAT, but it may be involved in the development of paranoid and delusional ideation during the course of mild DAT.
Department of Neuropsychiatry, Hyogo College of Medicine, Hyogo, Japan. satonori@hyo-med.ac.jp
Noriko
N
Sato
Akinori
A
Ueki
Hideo
H
Ueno
Hidetaka
H
Shinjo
Yoshio
Y
Morita
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D001057:Apolipoproteins E / Q000235:genetics; D001526:Behavioral Symptoms / Q000209:etiology* / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis; D000077265:Donepezil; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D008297:Male; D008609:Mental Status Schedule; D018697:Nootropic Agents / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D011110:Polymorphism, Genetic / Q000235:genetics*; D050637:Receptors, Dopamine D3 / Q000235:genetics*
D001057:Apolipoproteins E; D050483:Dopamine Plasma Membrane Transport Proteins; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D050637:Receptors, Dopamine D3; D000077265:Donepezil