Human transplant acceptance-inducing cells suppress mitogen-stimulated T cell proliferation.
The Transplant Acceptance-inducing Cell (TAIC) is a form of immunoregulatory macrophage which appears to be capable of establishing a state of alloantigen-specific partial tolerance of solid organ transplants in renal transplant recipients. This report establishes that human TAICs do not elicit a proliferative response from co-cultured allogeneic T cells. More significantly, it has been shown that TAICs are able to suppress proliferation of allogeneic CD4(+) and CD8(+) T cells after mitogenic stimulation. This suppressive activity can be attributed to the deletion of activated T cells by TAICs and to the secretion of a soluble inhibitor of T cell proliferation. It is further shown that the acquisition of T cell-suppressive properties by human TAICs depends upon an unidentified component of human serum.
Division of Experimental Surgery, Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
Paloma
P
Riquelme
Felix
F
Gövert
Edward K
EK
Geissler
Fred
F
Fändrich
James A
JA
Hutchinson
D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy / Q000379:methods; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000166:cytology / Q000276:immunology*; D008934:Mitogens / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D014181:Transplantation Immunology
D008934:Mitogens; D010835:Phytohemagglutinins