Glioma stem cells: not all created equal.
A growing body of evidence suggests that only a small subpopulation of malignant glioma cells have true tumorigenic potential. A study by Peñuelas et al. in this issue of Cancer Cell demonstrates that TGF-beta can stimulate self-renewal and inhibit differentiation in a proportion of these glioma-initiating cells.
Fine
Howard A
HA
Center for Cancer Research, Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. hfine@mail.nih.gov
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation / Q000502:physiology; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000502:physiology
D016212:Transforming Growth Factor beta