Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species.
Pregnane glycosides previously isolated from genus Caralluma (C. Penicillata, C. tuberculata and C. russelliana) were tested for their antitrypanosomal activity. Penicilloside E showed the highest antitrypanosomal activity (IC(50) 1.01 microg/ml) followed by caratuberside C (IC(50) 1.85 microg/ml), which exhibited the highest selectivity index (SI 12.04). It was noticed that acylation is required for the antitrypanosomal activity while glycosylation at C-20 has no significant effect on the activity.
Abdel-Sattar
Essam
E
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. abdelsattar@yahoo.com
Shehab
Naglaa G
NG
Ichino
Chikara
C
Kiyohara
Hiroaki
H
Ishiyama
Aki
A
Otoguro
Kazuhiko
K
Omura
Satoshi
S
Yamada
Haruki
H
D000215:Acylation; D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D002240:Carbohydrate Sequence; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D006031:Glycosylation; D006801:Humans; D008969:Molecular Sequence Data; D011278:Pregnanes / Q000737:chemistry / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects
D006027:Glycosides; D011278:Pregnanes; D014344:Trypanocidal Agents