Endocrine consequences of childhood malignancies.
Advances in cancer therapy over the last years have resulted in improved survival rates for pediatric cancer patients. However, new treatments are associated with short and long-term morbidity. The endocrine system is particularly sensitive to cancer therapies. Long-term survivors of childhood cancer are at risk for hypothalamic pituitary dysfunction, gonadal failure or disorders relating to pubertal progress, thyroid disease, obesity, disorders of lipid metabolism and disorders of bone and mineral metabolism. Long-term follow-up is indicated, as these disorders may not become apparent until adulthood.
Department of Growth and Development, "P & A Kyriakou" Children's Hospital, Athens, Greece. simatosgeorge@yahoo.com
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Karachaliou
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Simatos
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Batika
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Michalacos
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Kaldrymides
D000293:Adolescent; D000311:Adrenal Glands / Q000187:drug effects / Q000528:radiation effects; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001827:Body Height / Q000187:drug effects / Q000528:radiation effects; D001928:Brain Diseases, Metabolic / Q000209:etiology; D002318:Cardiovascular Diseases / Q000209:etiology; D002648:Child; D004703:Endocrine System / Q000187:drug effects* / Q000503:physiopathology / Q000528:radiation effects*; D006066:Gonads / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D009765:Obesity / Q000209:etiology; D011832:Radiation Injuries / Q000209:etiology* / Q000503:physiopathology; D011878:Radiotherapy / Q000009:adverse effects; D018570:Risk Assessment; D017741:Survivors; D013961:Thyroid Gland / Q000187:drug effects / Q000528:radiation effects; D016896:Treatment Outcome; D055815:Young Adult
D000970:Antineoplastic Agents