Ruthenium-catalyzed alkylation of oxindole with alcohols.
An atom-economical and solvent-free catalytic procedure for the mono-3-alkylation of oxindole with alcohols is described. The reaction is mediated by the in situ generated catalyst from RuCl(3) x xH(2)O and PPh(3) in the presence of sodium hydroxide. The reactions proceed in good to excellent yields with a wide range of aromatic, heteroaromatic, and aliphatic alcohols.
Jensen
Thomas
T
Department of Chemistry, Building 201, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Madsen
Robert
R
D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D000078183:Oxindoles; D012428:Ruthenium / Q000737:chemistry*
D000438:Alcohols; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D012428:Ruthenium