Bioreducible polymers for efficient gene and siRNA delivery.
Bioreducible disulfide linkage-employing drug conjugate has already been approved for drug delivery application, and also has shown immense potential in gene and siRNA transfection. This paper will focus on the recent developments in bioreducible polymeric systems for gene and siRNA delivery application, and will discuss the advantages and challenges associated with reducible polymeric carriers.
Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea.
Dhananjay
D
Jere
Rohidas
R
Arote
Hu-Lin
HL
Jiang
You-Kyoung
YK
Kim
Myung-Haing
MH
Cho
Chong-Su
CS
Cho
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D045744:Cell Line, Tumor; D004220:Disulfides / Q000737:chemistry; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000295:instrumentation / Q000379:methods; D005822:Genetic Vectors; D006801:Humans; D008954:Models, Biological; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000378:metabolism*; D014162:Transfection
D001672:Biocompatible Materials; D004220:Disulfides; D011108:Polymers; D034741:RNA, Small Interfering