Ras and pRb: the relationship gets yet more intimate.
Ras and pRb are key regulators of a plethora of cellular processes, including proliferation, differentiation, and tumorigenesis. Adding to several previously established lines of communication between the two, in this issue of Cancer Cell, Shamma et al. resolve a new signaling network involved in cellular senescence and tumor suppression.
Peeper
Daniel S
DS
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands. d.peeper@nki.nl
D000818:Animals; D002453:Cell Cycle; D016922:Cellular Senescence; D011905:Genes, ras / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D017368:Protein Prenylation; D016160:Retinoblastoma Protein / Q000502:physiology*
D016160:Retinoblastoma Protein