Chiral recognition of hybrid metal oxide by peptides.
Resolution of gram quantities of a subtly chiral polyoxometalate (POM; the chirality originates from substitution of one metal in the nanosized framework) is possible by reaction with small peptides. Functionalizable acyl polyoxotungstate (TBA)(6)[alpha(1)-P(2)W(17)O(61){SnCH(2)CH(2)C(=O)}] (see picture) can be resolved by kinetic resolution. This approach paves the way for applications of chiral POMs ranging from asymmetric catalysis to their bioactivity.
Micoine
Kévin
K
UPMC Univ Paris 06, Institut Parisien de Chimie Moléculaire (UMR CNRS 7201), C. 229, 4 place Jussieu, 75005 Paris, France.
Hasenknopf
Bernold
B
Thorimbert
Serge
S
Lacôte
Emmanuel
E
Malacria
Max
M
D053758:Nanoparticles / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013237:Stereoisomerism; D017973:Tungsten Compounds / Q000737:chemistry*
D010087:Oxides; D010455:Peptides; D011108:Polymers; D017973:Tungsten Compounds