Relationship between extracellular water fraction of total body water estimated by bioimpedance spectroscopy and cardiac troponin T in chronic haemodialysis patients.
OBJECTIVE
The ratio of extracellular water to total body water (ECW/TBW) estimated by bioimpedance spectroscopy (BIS) may be a useful volume index in haemodialysis (HD) patients, but its direct relation to cardiovascular (CV) outcomes has been rarely evaluated.


METHODS
We investigated the relationship between ECW/TBW by BIS and cardiac troponin T (cTnT) level, a biochemical surrogate of CV mortality.


RESULTS
Seventy-four HD patients without ischemic heart disease (age 51.6 +/- 13.2 years; male:female ratio 36:38; diabetes 37.8%) were recruited. Post-HD ECW/TBW was positively correlated to log cTnT levels (r = 0.60, p < 0.01). In multivariate regression models, male sex (beta = 0.23, p = 0.03), diabetes mellitus (beta = 0.21, p = 0.04), log high-sensitivity C-reactive protein (beta = 0.21, p = 0.04) and post-HD ECW/TBW (beta = 0.37, p < 0.01) were independent risk factors for elevated log cTnT levels.


CONCLUSIONS
Post-HD ECW/TBW by BIS is worthy of further evaluation as a pathophysiological index for reducing CV mortality in HD patients.
Division of Nephrology, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Jongha
J
Park
Hyun Chul
HC
Chung
Min Soo
MS
Kim
Shin-Jae
SJ
Kim
Jai Won
JW
Chang
Jong Soo
JS
Lee
D000328:Adult; D000368:Aged; D000886:Anthropometry; D001834:Body Water / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000503:physiopathology; D045604:Extracellular Fluid / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012044:Regression Analysis; D006435:Renal Dialysis; D012307:Risk Factors; D013057:Spectrum Analysis; D020107:Troponin T / Q000097:blood*
D020107:Troponin T