Comparison of paraben stability in human and rat skin.
Parabens are widely used preservatives in topical products, and are estrogenic in numerous experimental models. The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absorption of parabens, combined with low metabolism rates, may lead to prolonged estrogenic effects in the skin.
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Rd., Ann Arbor, MI 48105, USA.
Heather M
HM
Harville
Richard
R
Voorman
Jeffery J
JJ
Prusakiewicz
D000279:Administration, Cutaneous; D000818:Animals; D005260:Female; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D010226:Parabens / Q000493:pharmacokinetics*; D011310:Preservatives, Pharmaceutical / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013045:Species Specificity
D010226:Parabens; D011310:Preservatives, Pharmaceutical