Antibodies to Staphylococcus aureus bone sialoprotein-binding protein indicate infectious osteomyelitis.
Discrimination of soft tissue infection from osteomyelitis in diabetic foot infections is a common clinical problem. Staphylococcus aureus isolates from patients with osteomyelitis express bone sialoprotein-binding protein (Bbp) that binds the bone matrix protein bone sialoprotein. The serological assay with Bbp discriminated cases of osteomyelitis from soft tissue infections in patients with diabetic foot ulcers.
Department of Medical Biochemistry and Microbiology, Uppsala University BMC, Box 582, S-751 23 Uppsala, Sweden.
Lena
L
Persson
Christian
C
Johansson
Cecilia
C
Rydén
D000907:Antibodies, Bacterial / Q000097:blood*; D001426:Bacterial Proteins / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D048909:Diabetes Complications; D017719:Diabetic Foot / Q000382:microbiology; D003937:Diagnosis, Differential; D006801:Humans; D010019:Osteomyelitis / Q000175:diagnosis* / Q000382:microbiology; D018461:Soft Tissue Infections / Q000175:diagnosis* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000276:immunology*
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D002352:Carrier Proteins; C405490:bone sialoprotein-binding protein, Staphylococcus aureus