Apixaban, an oral direct factor Xa inhibitor, inhibits human clot-bound factor Xa activity in vitro.
Xiaosui
X
Jiang
Earl J
EJ
Crain
Joseph M
JM
Luettgen
William A
WA
Schumacher
Pancras C
PC
Wong
D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D015951:Factor Xa / Q000378:metabolism; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D010446:Peptide Fragments / Q000097:blood; D011516:Prothrombin; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D011728:Pyridones / Q000008:administration & dosage / Q000494:pharmacology*; D013927:Thrombosis / Q000097:blood*
D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents; D010446:Peptide Fragments; D011720:Pyrazoles; D011728:Pyridones; C045879:prothrombin fragment 1.2; C522181:apixaban; D011516:Prothrombin; D015951:Factor Xa