Modelling and measuring redox cycling and cytotoxicity of quinones.
The roles of alkylation and redox cycling in quinone toxicity were investigated. In general the more cytotoxic quinones produced the highest responses in an assay monitoring redox activity. No evidence of alkylation of high molecular weight protein thiols was detected. We conclude quinone toxicity is dominated by redox cycling.
School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia.
Louise
L
Hughes
Jordana
J
Wingate
Renate
R
Griffith
R John
RJ
Aitken
D000478:Alkylation; D000818:Animals; D002460:Cell Line; D051379:Mice; D008954:Models, Biological; D008970:Molecular Weight; D010084:Oxidation-Reduction; D011809:Quinones / Q000737:chemistry / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D018675:Toxicity Tests / Q000379:methods*
D011809:Quinones; D013438:Sulfhydryl Compounds