Paratesticular müllerian-type papillary serous tumor in a child.
We describe a case of a 15-year-old male presenting with an unusual right-sided paratesticular mass in whom the diagnosis of an ovarian-like paratesticular müllerian-type papillary serous tumor was made. The tumor, also referred to as serous papillary cystadenoma by some authors, depicted papillae with fibro-vascular cores lined by a bland pseudostratified ciliated epithelium. The immunohistochemistry showed the tumor to have diffuse reactivity against BerEp4, epithelial membrane antigen, and progesterone receptor; focal reactivity against cytokeratins AE1/AE3, cytokeratin 7 (CK7), Ca125, estrogen, and carcinoembryonic antigen; and negative reactivity for calretinin, Wilms tumor 1 (WT1), and CK20. Surgical management involved resection of the tumor followed by regular follow-up. Paratesticular müllerian-type papillary serous tumor is an infrequent lesion that has seldom been described in the pediatric-age patient. To our knowledge, whereas only 2 cases of serous papillary borderline malignancy have been previously described in this age group, this is the 1st time a serous papillary tumor is reported in a child. The pediatric surgeon, the clinicians, and the pathologist should be aware of this entity, as a conservative management would be preferable.
Department of Histopathology, Sheffield Children's NHS Foundation Trust, Western Bank, Sheffield, S10 2TH, United Kingdom. Marta.Cohen@sch.nhs.uk
Marta C
MC
Cohen
Rang
R
Shawis
Clair
C
Evans
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D018283:Cystadenocarcinoma, Papillary / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013736:Testicular Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor