Targeting the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta signaling pathway to limit neurotoxicity induced by drug abuse.
This review compiles the scientific basis to propose the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta signaling pathway as a new therapeutic target to prevent drug of abuse-induced toxicity. In addition, potential guidelines are provided for the development of new therapeutic compounds derived from that knowledge. This approach may be relevant since efficient therapeutic strategies are currently lacking in this field, even when drug-induced neurotoxicity seems to underlie the neurodegenerative disorders diagnosed in drug addicts.
Herradón
Gonzalo
G
Lab. Pharmacology and Toxicology, Universidad CEU San Pablo, Urb. Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain. herradon@ceu.es
Ezquerra
Laura
L
Gramage
Esther
E
Alguacil
Luis F
LF
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology* / Q000627:therapeutic use*; D016207:Cytokines / Q000502:physiology* / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D055808:Drug Discovery; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects; D020258:Neurotoxicity Syndromes / Q000150:complications* / Q000188:drug therapy*; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5 / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D019966:Substance-Related Disorders / Q000150:complications*
D002352:Carrier Proteins; D016207:Cytokines; D013287:Illicit Drugs; C066845:pleiotrophin; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5