Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.
Fully integrated: Mass spectrometry has been integrated into a detection scheme for microdroplets that are created within microfluidic channels (see picture, scale bar 200 microm). This technique allows droplets to be identified based on the compounds they contain, and combines fluorescence screening with MS analysis. These experiments indicate how similar approaches can be applied to the ambitious goals of on-chip protein evolution and chemical synthesis.
Fidalgo
Luis M
LM
Melville laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
Whyte
Graeme
G
Ruotolo
Brandon T
BT
Benesch
Justin L P
JL
Stengel
Florian
F
Abell
Chris
C
Robinson
Carol V
CV
Huck
Wilhelm T S
WT