Effectiveness of mycotoxin sequestration activity of micronized wheat fibres on distribution of ochratoxin A in plasma, liver and kidney of piglets fed a naturally contaminated diet.
A study was carried out to determine the ability of dietary micronized wheat fibres (MWF) to decrease the levels of ochratoxin A (OTA) in plasma, kidney and liver of piglets fed a naturally contaminated diet. A total of 96 piglets (weighting 11.4+/-1.5 kg) were fed one of four different diets for 28 days. Diets included (1) control diet, (2) control diet with MWF (1%), (3) OTA naturally contaminated diet (117.45+/-4.74 ng/g), (4) OTA naturally contaminated diet (118.13+/-2.85 ng/g) with MWF (1%). No difference in feed efficiency (P>0.05) could be observed between the different diets. The absolute weight of kidneys and liver were significantly higher in pigs fed the OTA-contaminated diet (diet 3) as compared to the control diet (diet 1) or to the control diet amended with MWF (diet 2) (P<0.05). However the use of MWF (diet 4) significantly protected against these weight changes. A significant protective effect of MWF was also observed in terms of OTA concentration in plasma (45.6% decrease), kidney (40.8% decrease) and liver (26.5% decrease). These results suggest that the addition of MWF is effective in decreasing the bioavailability of OTA from contaminated diets in piglets.
Unité de Biochimie de la Nutrition, Faculté d'Ingénierie Biologique, Agronomique et Environnementale, Croix du sud 8/02, Université Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium.
N
N
Aoudia
P
P
Callu
F
F
Grosjean
Y
Y
Larondelle
D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002273:Carcinogens / Q000493:pharmacokinetics*; D002846:Chromatography, Affinity; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology*; D005260:Female; D005506:Food Contamination / Q000032:analysis; D006128:Growth / Q000187:drug effects; D007120:Immunochemistry; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009183:Mycotoxins / Q000378:metabolism*; D009793:Ochratoxins / Q000097:blood / Q000493:pharmacokinetics*; D009929:Organ Size / Q000187:drug effects; D013552:Swine; D014018:Tissue Distribution; D014908:Triticum / Q000737:chemistry*
D002273:Carcinogens; D004043:Dietary Fiber; D009183:Mycotoxins; D009793:Ochratoxins; C025589:ochratoxin A