The race and dose of chemotherapy should be considered for optimizing maintenance therapy for acute promyelocytic leukemia.
Although European conventional maintenance therapy for acute promyelocytic leukemia consisting of all-trans retinoic acid, 6-mercaptopurine, and methotrexate has been adopted in some trials, the adverse events of this therapy have not been described well. We describe adverse events of this therapy in detail and we find that the tolerance of maintenance therapy may depend on the race. Our results indicate that the race and dose intensity should be considered in addition to the number of consolidation courses and PML/RARA mRNA status in configuring the optimal regimen of maintenance therapy, because tolerability may depend much on the races and dose intensity.
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 1138655, Japan.
Sumimasa
S
Nagai
Yasuhito
Y
Nannya
Akira
A
Hangaishi
Tsuyoshi
T
Takahashi
Mineo
M
Kurokawa
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004361:Drug Tolerance / Q000235:genetics / Q000502:physiology*; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects / Q000627:therapeutic use; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D044469:Racial Groups; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use
D000970:Antineoplastic Agents; D014212:Tretinoin; D015122:Mercaptopurine; D008727:Methotrexate