[Angiotensin (1-7) receptor].
Mas, which was protooncogene, first detected in vivo by tumorigenic properties originating from rearrangement of its 5'-flanking region was identified as a functional receptor for angiotensin (1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide. Angiotensin (1-7) is mainly produced from angiotensin II by angiotensin converting enzyme 2, homologue of angiotensin converting enzyme. Many investigations suggested angiotensin (1-7) via Mas receptor might play protective effects on hypertensive complications, such as renal dysfunction and cardiovascular diseases, competed with angiotensin II and its type 1 receptor.
Department of Geriatric Medicine, Graduate School of Medicine, Osaka University.
Mitsuru
M
Ohishi
Hiromi
H
Rakugi
D000818:Animals; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000096:biosynthesis / Q000502:physiology*
D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled