Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1.
Thymosin beta 4 (T beta 4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, T beta 4's functions in relation to natural killer(NK) cells are still unknown. In this study, we show that synthetic T beta 4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that T beta 4 is a key activator of NK cell cytotoxicity.
Lee
Ha-reum
HR
Department of Life Science, Sookmyung Women's University, Hyochangwon-gil 52, Yongsan-gu, Seoul 140-742, Republic of Korea.
Yoon
Sun Young
SY
Kang
Ho-Bum
HB
Park
Sunyoung
S
Kim
Kyung-Eun
KE
Cho
Young Hoon
YH
Kim
Seonghan
S
Kim
Chul-woo
CW
Cho
Byung Joo
BJ
Lee
Wang Jae
WJ
Bang
Sa Ik
SI
Park
Hyunjeong
H
Cho
Daeho
D
D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D005089:Exocytosis; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology; D010455:Peptides / Q000276:immunology / Q000494:pharmacology; D013947:Thymosin / Q000276:immunology* / Q000494:pharmacology; D015854:Up-Regulation; D000099201:Thymosin beta(4)
D018799:Intercellular Adhesion Molecule-1; D016169:Lymphocyte Function-Associated Antigen-1; D010455:Peptides; D013947:Thymosin; D000099201:Thymosin beta(4)