Effects of in utero exposure to 2,2',4,4',5,5'-hexachlorobiphenyl on postnatal development and thyroid function in rat offspring.
Exposure to polychlorobiphenyls (PCBs) has been reported to affect endocrine glands; however, little is known about the precise toxicological properties of individual PCBs. We determined whether prenatal exposure to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153), a di-ortho-substituted non-coplanar congener, affects postnatal development in rat offspring. Pregnant Sprague-Dawley rats were given PCB 153 (0, 1, or 4 mg/kg/d) orally from gestational day (GD) 10 to 16, and somatic parameters and thyroid functions in offspring were examined. We found no dose-dependent changes in body weight, body length, tail length, or weight of liver, kidney, testis, seminal vesicle, prostate, ovary, relative organ weight, anogenital distance (AGD), or AGD index in offspring at 1, 3 or 9 wk of age. We observed no compound-related changes in the plasma concentrations of thyroxine (T(4)), tri-iodothyronine (T(3)) or thyroid-stimulating hormone (TSH), although there was a significant difference in T(3) only in 1-wk-old males. In addition, thyroid glands from PCB 153 groups had normal T(4) responses to exogenous TSH in vivo. These findings suggest that low doses of PCB 153 given prenatally (GD 10-16, 1-4 mg/kg/d) might have little effect on postnatal somatic growth or thyroid development of male and female rat offspring under the experimental conditions of the present study.
National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, Kawasaki 214-8585, Japan.
Kenichi
K
Kobayashi
Muneyuki
M
Miyagawa
Rui-Sheng
RS
Wang
Megumi
M
Suda
Soichiro
S
Sekiguchi
Takeshi
T
Honma
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring; D005260:Female; D048788:Growth and Development / Q000187:drug effects*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011467:Prostate / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012669:Seminal Vesicles / Q000473:pathology; D013737:Testis / Q000473:pathology; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D011078:Polychlorinated Biphenyls; D013974:Thyroxine; C014024:2,4,5,2',4',5'-hexachlorobiphenyl