De novo design of a beta alpha beta motif.
A designer monomeric protein with a beta alpha beta fold--two parallel beta strands connected by an alpha helix (see structure)--was constructed solely from coded amino acids. The high thermal stability of the structure is due to a large extent to tryptophan-tryptophan interactions between the two beta strands.
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Huanhuan
H
Liang
Hao
H
Chen
Keqiang
K
Fan
Ping
P
Wei
Xianrong
X
Guo
Changwen
C
Jin
Chen
C
Zeng
Chao
C
Tang
Luhua
L
Lai
D020816:Amino Acid Motifs / Q000235:genetics; D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D009154:Mutation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000235:genetics
D011506:Proteins