OC-125 immunostaining in endometriotic lesion samples.
OBJECTIVE
To determine the presence of OC-125 staining in endometriotic lesions and to verify whether there is an association with endometriosis stage.


METHODS
Thirteen patients from the Family Planning programs (group I) and 53 patients from the Chronic Pelvic Pain outpatient clinic (group II) were studied. Endometriotic lesions were excised from areas of endometriosis incidence and studied by histopathological assay and by immunohistochemistry for OC-125 staining.


RESULTS
The histopathological study disclosed that all patients from group I had minimal/mild endometriosis. In group II, 39.6% had minimal/mild endometriosis, and 60.4% had moderate/severe endometriosis. OC-125 staining was negative in all samples from group I. In group II, OC-125 staining was positive in 52.4% patients with minimal/mild endometriosis and in 81.2% with moderate/severe endometriosis.


CONCLUSIONS
The data suggest that the OC-125 antibody is probably related to endometriosis activity and, consequently, to the progression and severity of the illness.
Disciplina de Genética e Reprodução Humana, Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina do ABC, FMABC, Avenida Príncipe de Gales 821, Prédio CEPES, Santo André, São Paulo,Brazil. caiopb@uol.com.br
Caio Parente
CP
Barbosa
Angela Mara Bentes
AM
de Souza
Bianca
B
Bianco
Denise Maria
DM
Christofolini
Fernanda Abani
FA
Mafra
Geraldo Rodrigues
GR
de Lima
D000328:Adult; D000911:Antibodies, Monoclonal; D018394:CA-125 Antigen / Q000032:analysis*; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry
D000911:Antibodies, Monoclonal; D018394:CA-125 Antigen