Differential testicular gene expression in seasonal fertility.
Spermatogenesis is an essential precursor for successful sexual reproduction. Recently, there has been an expansion in the knowledge of the genes associated with particular stages of normal, physiological testicular development and pubertal activation. What has been lacking, however, is an understanding of those genes that are involved in specifically regulating sperm production, rather than in maturation and elaboration of the testis as an organ. By using the reversible (seasonal) fertility of the Syrian hamster as a model system, the authors sought to discover genes that are specifically involved in turning off sperm production and not involved in tissue specification and/or maturation. Using gene expression microarrays and in situ hybridization in hamsters and genetically infertile mice, the authors have identified a variety of known and novel factors involved in reversible, transcriptional, translational, and posttranslational control of testicular function, as well those involved in cell division and macromolecular metabolism. The novel genes uncovered could be potential targets for therapies against fertility disorders.
MRC Laboratory of Molecular Biology, Cambridge, UK.
Elizabeth S
ES
Maywood
Samira
S
Chahad-Ehlers
Martine L
ML
Garabette
Claire
C
Pritchard
Phillip
P
Underhill
Andrew
A
Greenfield
Francis J P
FJ
Ebling
Ruth A
RA
Akhtar
Charalambos P
CP
Kyriacou
Michael H
MH
Hastings
Akhilesh B
AB
Reddy
D000818:Animals; D006224:Cricetinae; D005298:Fertility / Q000502:physiology*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008647:Mesocricetus; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D017440:Photoperiod; D012621:Seasons; D013091:Spermatogenesis / Q000502:physiology; D013737:Testis / Q000502:physiology*