Copper(II) and uranyl(II) complexes with acylthiosemicarbazide: synthesis, characterization, antibacterial activity and effects on the growth of promyelocytic leukemia cells HL-60.
New chelates of N(1)-[4-(4-X-phenylsulfonyl)benzoyl]-N(4)-butyl-thiosemicarbazide (X=H, Cl, Br) with Cu(2+) and UO(2)(2+) have been prepared and characterized by analytical and physico-chemical techniques such as magnetic susceptibility measurements, elemental and thermal analyses, electronic, ESR and IR spectral studies. Room temperature ESR spectra of Cu(II) complexes yield {g} values characteristic of distorted octahedral and pseudo-tetrahedral geometry. Infrared spectra indicate that complexes contain six-coordinate uranium atom with the ligand atoms arranged in an equatorial plane around the linear uranyl group. Effects of these complexes on the growth of human promyelocytic leukemia cells HL-60 and their antibacterial activity (against Staphylococcus epidermidis ATCC 14990, Bacillus subtilis ATCC 6633, Bacillus cereus ATCC 14579, Pseudomonas aeruginosa ATCC 9027 and Escherichia coli ATCC 11775 strains) were studied comparatively with that of free ligands.
Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, Bucharest, Romania.
Madalina Veronica
MV
Angelusiu
Gabriela Laura
GL
Almajan
Tudor
T
Rosu
Maria
M
Negoiu
Eva-Ruxandra
ER
Almajan
Jenny
J
Roy
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D018922:HL-60 Cells; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D008024:Ligands; D008280:Magnetics; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012663:Semicarbazides / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D014501:Uranium / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D012663:Semicarbazides; D014501:Uranium; C005151:thiosemicarbazide; D003300:Copper