Design and synthesis of bisenediyne bissulfones and their reactivity under basic condition.
A new class of bisenediyne bis sulfones has been synthesized. These molecules underwent cycloaromatization under basic conditions via isomerization to allene and were able to cleave ds-stranded plasmid DNA.
Das
Sanket
S
Department of Chemistry, Indian Institute of Technology, Kharagpur, India.
Basak
Amit
A
D000466:Alkadienes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D053837:DNA Cleavage; D015195:Drug Design; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry
D000466:Alkadienes; D013450:Sulfones; C025947:propadiene