Wilms tumor, AML and medulloblastoma in a child with cancer prone syndrome of total premature chromatid separation and Fanconi anemia.
Wilms tumor (WT) is the most common primary renal tumor in childhood. The occurrence of WT in patients with growth retardation, mental retardation and central nervous system abnormalities in association with premature chromatid separation (PCS) and mosaic variegated aneuploidy has been previously described in only 10 patients. Here we report the very rare occurrence of WT with two other malignancies, acute myeloid leukemia and medulloblastoma in association with chromosomal instability. This is a novel presentation of Fanconi anemia with this cytogenetic abnormality.
Sari
Neriman
N
Department of Pediatric Oncology, Ankara Oncology Hospital, Ankara, Turkey. neriman@meddata.com.tr
Akyuz
Canan
C
Aktas
Dilek
D
Gumruk
Fatma
F
Orhan
Diclehan
D
Alikasifoglu
Mehmet
M
Aydin
Burca
B
Alanay
Yasemin
Y
Buyukpamukcu
Munevver
M
D000015:Abnormalities, Multiple; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D002675:Child, Preschool; D049914:DNA Repair-Deficiency Disorders / Q000150:complications* / Q000473:pathology; D005199:Fanconi Anemia / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008527:Medulloblastoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009396:Wilms Tumor / Q000150:complications* / Q000188:drug therapy / Q000473:pathology