Antioxidants suppress Th1-type immune response in vitro.
Inflammation is a hallmark of various diseases like infections, autoimmune syndromes, cardiovascular and neurodegenerative disorders, and cancer. Thereby, Th1-type cytokine interferon-gamma is a central pro-inflammatory mediator. Antioxidant compounds counteract the activation of T-cells and macrophages. This anti-inflammatory activity could be important for the development of immunotolerance and for treatment of above-mentioned disorders.
Schroecksnadel
Katharina
K
Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Str. 3, A-6020 Innsbruck, Austria.
Fischer
Birgit
B
Schennach
Harald
H
Weiss
Guenter
G
Fuchs
Dietmar
D
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D010936:Plant Extracts / Q000494:pharmacology; D018417:Th1 Cells / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts; D007371:Interferon-gamma