Does opioid therapy affect quality of care for diabetes mellitus?
OBJECTIVE
To examine whether veterans who received chronic opioid therapy had worse diabetes performance measures than patients who did not receive opioids.


METHODS
Retrospective cohort study.


METHODS
We identified all patients with diabetes mellitus receiving care in US Department of Veterans Affairs facilities during 2004. Cases received at least 6 prescriptions for chronic opioids during 2004, while controls were randomly selected from among patients with diabetes who received no opioids. We compared process measures (glycosylated hemoglobin and low-density lipoprotein cholesterol levels tested and an eye examination performed) and outcome measures (glycosylated hemoglobin level < or =9.0% and low-density lipoprotein cholesterol level < or =130 mg/dL) between groups.


RESULTS
Cases (n = 47,756) had slightly worse diabetes performance measures than controls (n = 220,912) after adjustment for covariates. For example, 86.4% of cases and 89.0% of controls had a glycosylated hemoglobin test during fiscal year 2004 (adjusted odds ratio, 0.69; P <.001). Among cases, receipt of higher-dose opioids was associated with additional decrement in diabetes performance measures, with a dose-response relationship.


CONCLUSIONS
Chronic opioid therapy among patients within the Veterans Affairs system is associated with slightly worse diabetes performance measures compared with patients who do not receive opioids. However, patients receiving higher dosages of opioids had additional decrements in diabetes performance measures; these patients may be appropriate targets for interventions to improve their care for pain and diabetes.
Center for Health Quality, Outcomes, and Economic Research, Bedford VA Medical Center, 200 Springs Rd, Bldg 70, Bedford, MA 01730, USA. adamrose@bu.edu
Adam J
AJ
Rose
John A
JA
Hermos
Susan M
SM
Frayne
Leonard M
LM
Pogach
Dan R
DR
Berlowitz
Donald R
DR
Miller
D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014481:United States; D014728:Veterans; D015351:Vision Screening / Q000706:statistics & numerical data
D000701:Analgesics, Opioid; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin