Severe multivessel coronary spasm after sirolimus-eluting stent implantation.
We describe two cases of severe, multivessel coronary vasospasm that occurred a few months after placement of sirolimus-eluting stents in patients with severe coronary disease, and involved segments not significantly atheromatous and not previously treated. The literature suggests that biocellular interference with the endothelial equilibrium on the part of drugs eluted from a stent poses a serious risk of tardive and widespread postangioplasty coronary spasm in comparison with the use of a bare-metal stent.
Cardiology Department, 'Ospedale degli Infermi', Rivoli (Torino), Italy. emodinamica@asl5.piemonte.it
Francesco
F
Tomassini
Ferdinando
F
Varbella
Andrea
A
Gagnor
Vincenzo
V
Infantino
Stefania
S
Luceri
Maria Rosa
MR
Conte
D000787:Angina Pectoris / Q000209:etiology / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000295:instrumentation*; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D003329:Coronary Vasospasm / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D054855:Drug-Eluting Stents; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D012720:Severity of Illness Index; D020123:Sirolimus / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
D002317:Cardiovascular Agents; D014665:Vasodilator Agents; D020123:Sirolimus