C-reactive protein levels and radiation-induced mucositis in patients with head-and-neck cancer.
OBJECTIVE
To evaluate the relationship between C-reactive protein (CRP) levels or the erythrocyte sedimentation rate (ESR) and the grade of acute radiation-induced mucositis in patients with head-and-neck cancer.


METHODS
This study was performed in 40 patients who received intensity-modulated radiation therapy as a radical treatment of primary laryngo-pharyngeal cancer. Serum CRP level and ESR were initially checked on the day of radiotherapy simulation and were measured every week during the irradiation schedule and two times biweekly after radiotherapy. Mucosal reactions were evaluated by radiation oncologists on days of blood sampling.


RESULTS
The distribution of the most severe mucositis was Grade I mucositis in 10% of the patients, Grade II in 60% of the patients and Grade III in 30% of the patients. Statistical analysis indicated a significant rise in the CRP level (p < 0.001) according to radiation fraction number and grade of mucositis. A change of the mean CRP level was correlated with progression of mean grade of mucositis according to fraction number. The ESR did not show any statistically significant relationship with radiotherapy fraction number and grade of acute mucositis.


CONCLUSIONS
There was a significant correlation between the presence of acute mucositis and CRP level in this study. The CRP level could be conveniently determined along with evaluation of mucosal reactions during or after radiotherapy to provide further information on radiation-induced mucositis.
Department of Radiation Oncology, Pusan National University School of Medicine, Busan, Korea.
Yongkan
Y
Ki
Wontaek
W
Kim
Jiho
J
Nam
Donghyun
D
Kim
Dahl
D
Park
Dongwon
D
Kim
D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000528:radiation effects; D052016:Mucositis / Q000097:blood* / Q000473:pathology; D011832:Radiation Injuries / Q000097:blood* / Q000473:pathology; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects* / Q000379:methods
D015415:Biomarkers; D002097:C-Reactive Protein