Circadian biology: an unexpected invitee to new time zones.
Adaptation to changing light conditions is a hallmark of the circadian clock. A new study points to the critical role played by a transcriptional repressor previously implicated in cell differentiation, highlighting unappreciated links between the clock and the control of development and tumorigenesis.
Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA.
Satoru
S
Masubuchi
Paolo
P
Sassone-Corsi
D056930:ARNTL Transcription Factors; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D001522:Behavior, Animal / Q000502:physiology; D001683:Biological Clocks / Q000502:physiology*; D056926:CLOCK Proteins; D002940:Circadian Rhythm / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D051797:Inhibitor of Differentiation Protein 2 / Q000235:genetics / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D056950:Period Circadian Proteins; D013997:Time Factors; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism
D056930:ARNTL Transcription Factors; D051792:Basic Helix-Loop-Helix Proteins; D056926:CLOCK Proteins; D051797:Inhibitor of Differentiation Protein 2; D047908:Intracellular Signaling Peptides and Proteins; D056950:Period Circadian Proteins; D015534:Trans-Activators; C538960:BMAL1 protein, human; C538961:Bmal1 protein, mouse; C497452:Idb2 protein, mouse; C539022:PER1 protein, human; C539023:Per1 protein, mouse; C538943:CLOCK protein, human; C538944:Clock protein, mouse