Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
To investigate whether 6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine (ABO) inhibits oxidized low-density lipoprotein (oxLDL)-induced human umbilical vein endothelial cell (HUVEC) apoptosis, we treated HUVECs with oxLDL in the absence or presence of ABO. The results showed that ABO could act as an effective inhibitor of oxLDL-elicited HUVEC apoptosis by inhibiting the levels of integrin beta4, reactive oxygen species (ROS), NF-kappaB and P53, and suppressing NF-kappaB nuclear translocation.
Institute of Developmental Biology, Shandong University, Jinan, China.
Xia
X
Liu
Jing
J
Zhao
JiPing
J
Xu
BaoXiang
B
Zhao
Yun
Y
Zhang
ShangLi
S
Zhang
JunYing
J
Miao
D017209:Apoptosis; D048588:Benzoxazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D039663:Integrin beta4 / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000494:pharmacology; D016328:NF-kappa B / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D014471:Umbilical Veins / Q000166:cytology
C541593:6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine; D048588:Benzoxazines; D039663:Integrin beta4; D008077:Lipoproteins, LDL; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53; C099252:oxidized low density lipoprotein