[Acute immuno-allergic interstitial nephritis after treatment with fluindione. Seven cases].
We report seven cases of patients treated with fluindione, who presented with acute renal failure, associated with clinical features of allergy: poor status, fever, dyspnea, lymphadenopathy and erythroderma. All patients had elevated eosinophil counts. Renal biopsy disclosed in all cases a tubulo-interstitial nephritis with or without granuloma. The responsibility of fluindione, an oral anticoagulant widely used in France could be demonstrated. To our knowledge, there are only three reports of single cases of acute renal failure related to fluindione published so far to date. This serious side effect of fluindione should be recognized.
Centre hospitalier de Bigorre-Tarbes, service d'hémodialyse, boulevard de Maréchal-de-Lattre-de-Tassigny, 65013 Tarbes cedex 9, France. freynaud@ch-tarbes-vic.fr
Franck
F
Reynaud
Patrick
P
Giraud
Jean-Marc
JM
Cisterne
Daniel
D
Verdier
Zeinab
Z
Kouchakipour
Alain
A
Hermelin
Anne
A
Modesto-Segonds
Haleh
H
Bagheri
Jacques
J
Pourrat
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology*; D010630:Phenindione / Q000009:adverse effects / Q000031:analogs & derivatives*
D000925:Anticoagulants; D010630:Phenindione; C017673:fluindione