Novel taxane formulations and microtubule-binding agents in non-small-cell lung cancer.
Antitubulin agents are among the most active drugs for the treatment of non-small-cell lung cancer. The taxanes paclitaxel and docetaxel are highly active and frequently used for adjuvant therapy after resection of localized disease and in combination with radiation for locally advanced disease and treatment of patients with advanced disease. Despite their benefits, these drugs have significant problems, including toxicity and limited efficacy. Recently, new taxane formulations and novel antitubulin agents have been developed. In some cases, these drugs have reduced toxicity with preserved efficacy. In other cases, these agents have potentially unique activity and have now advanced to late-stage trials. This review evaluates 2 novel paclitaxel formulations, albumin-bound paclitaxel and paclitaxel poliglumex. New antimicrotubulin agents, including the epothilones, colchicine-binding antivascular agents, and vinca alkaloids, are also discussed.
Edelman
Martin J
MJ
University of Maryland, Greenebaum Cancer Center, Baltimore, MD 21201, USA. medelman@umm.edu
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001632:Bibenzyls / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D019008:Drug Resistance, Neoplasm; D034261:Epothilones / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000031:analogs & derivatives / Q000627:therapeutic use; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D050257:Tubulin Modulators / Q000627:therapeutic use*; D014747:Vinblastine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077235:Vinorelbine
D000970:Antineoplastic Agents; D001632:Bibenzyls; D034261:Epothilones; D050257:Tubulin Modulators; D011099:Polyglutamic Acid; D014747:Vinblastine; C040105:combretastatin; D017239:Paclitaxel; D000077235:Vinorelbine; C509139:paclitaxel poliglumex