Clinical impact of hemodynamic parameter measurement for cerebrovascular disease using positron emission tomography and (15)O-labeled tracers.
Positron emission tomography (PET) measurement of cerebral blood flow and metabolism has been a basic and standard method for evaluation of hemodynamics in patients with cerebral vascular disease (CVD). Despite the recent rapid spread of PET and PET/CT facilities, the number of patient examinations with (15)O-gas PET scans is declining because most facilities are used for cancer studies. They avoid (15)O-gas PET study because it is time consuming and the technique and calculation methods appear to be complicated. However, reconsidering the benefits and usefulness of conventional (15)O-gas PET study is a good opportunity to understand its potential possibility. Physiological evaluation of cerebral perfusion and metabolism provided the basic concept of hemodynamics in impaired circulation and the development of evidence-based medicine in neurosurgical treatment for CVD. This method can be used for two major objectives, clinical examination with a less-invasive simplified method, and quantitative precise measurements with model analysis for research purposes. Both are important for developing further practical and investigational approaches using (15)O-gas PET.
Okazawa
Hidehiko
H
Division of Medical Imaging, Biomedical Imaging Research Center (BIRC), University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Fukui 910-1193, Japan. okazawa@u-fukui.ac.jp
Kudo
Takashi
T
D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D010104:Oxygen Radioisotopes / Q000737:chemistry; D049268:Positron-Emission Tomography; D011849:Radioactive Tracers; D013194:Staining and Labeling
D010104:Oxygen Radioisotopes; D011849:Radioactive Tracers