Update on the podocyte.
OBJECTIVE
The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets. This article will review recent advances in understanding the complex biology, structure and function of the podocyte and the related clinical implications.


RESULTS
Recent studies of podocytes in vivo and in vitro are described, highlighting clinically relevant observations and those that help us to understand the ways in which we may harness nature's own mechanisms to repair and/or renew these specialized glomerular cells.


CONCLUSIONS
Drugs that have beneficial effects on podocytes can improve our ability to treat important renal diseases, including diabetic nephropathy. Currently available agents can be harnessed in this way and the rapid progress in the study of podocytes is highlighting new therapeutic targets that can bring even more specificity.
Mathieson
Peter W
PW
Faculty of Medicine & Dentistry, University of Bristol, Bristol, UK. p.mathieson@bris.ac.uk
D000818:Animals; D017690:Cell Transplantation; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy / Q000473:pathology; D007678:Kidney Glomerulus / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology; D035683:MicroRNAs / Q000235:genetics; D009404:Nephrotic Syndrome / Q000378:metabolism; D050199:Podocytes / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D012076:Renal Agents / Q000494:pharmacology / Q000627:therapeutic use
D035683:MicroRNAs; D011506:Proteins; D012076:Renal Agents