Lateralization of the arcuate fasciculus from childhood to adulthood and its relation to cognitive abilities in children.
The arcuate fasciculus is a major white matter tract involved in language processing that has also been repeatedly implicated in intelligence and reasoning tasks. Language in the human brain is lateralized in terms of both function and structure, and while the arcuate fasciculus reflects this asymmetry, its pattern of lateralization is poorly understood in children and adolescents. We used diffusion tensor imaging (DTI) and tractography to examine arcuate fasciculus lateralization in a large (n = 183) group of healthy right-handed volunteers aged 5-30 years; a subset of 68 children aged 5-13 years also underwent cognitive assessments. Fractional anisotropy and number of streamlines of the arcuate fasciculus were both significantly higher in the left hemisphere than the right hemisphere in most subjects, although some subjects (10%) were right lateralized. Age and gender effects on lateralization were not significant. Children receiving cognitive assessments were divided into three groups: a "left-only" group in whom only the left side of the arcuate fasciculus could be tracked, a left-lateralized group, and a right-lateralized group. Scores on the Peabody Picture Vocabulary Test (PPVT) and NEPSY Phonological Processing task differed significantly among groups, with left-only subjects outperforming the right-lateralized group on the PPVT, and the left-lateralized children scoring significantly better than the right-lateralized group on phonological processing. In summary, DTI tractography demonstrates leftward arcuate fasciculus lateralization in children, adolescents, and young adults, and reveals a relationship between structural white matter lateralization and specific cognitive abilities in children.
Department of Biomedical Engineering, University of Alberta, Alberta, Canada.
Catherine
C
Lebel
Christian
C
Beaulieu
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D002648:Child; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology*; D009483:Neuropsychological Tests; D055815:Young Adult