NADPH oxidase signaling and cardiac myocyte function.
The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.
Akki
Ashwin
A
Department of Cardiology, King's College London British Heart Foundation Centre of Excellence, The James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK.
Zhang
Min
M
Murdoch
Colin
C
Brewer
Alison
A
Shah
Ajay M
AM
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D006332:Cardiomegaly / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D032383:Myocytes, Cardiac / Q000378:metabolism*; D019255:NADPH Oxidases / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D007527:Isoenzymes; D019255:NADPH Oxidases