Age-associated elongation of the ascending aorta in adults.
OBJECTIVE
To determine whether human aorta lengthens with aging and to evaluate the impact of the hypothesized aortic elongation on pulse wave velocity (PWV) measurements.


BACKGROUND
Although it is generally thought that the aorta becomes tortuous with aging, there has been no systematic study to date in healthy adults to determine if this is so. Such age-related aortic elongation may be a confounding factor for the PWV measurement in elderly people.


METHODS
Arterial lengths were computed by the 3-dimensional transverse magnetic resonance image arterial tracing of the aorta and carotid and iliac arteries in 256 apparently healthy adults (age 19 to 79 years).


RESULTS
The ascending aorta was greater with advancing age (r = 0.72), whereas the lengths of the descending aorta and carotid and iliac arteries were not associated with age. The elongation of the ascending aorta was associated with the corresponding increases in aortic PWV (beta = 0.50) and brachial/aortic pulse pressure ratio (beta = 0.24), which is an index of pulse wave amplification. The straight distance between carotid and femoral sites (car-fem), the most popular arterial length measurement, overestimated the aortic length measured with the magnetic resonance image by approximately 25%. The most accurate arterial length estimation was the distance obtained by subtracting carotid length from the car-fem, with <5% difference from the magnetic resonance image-measured length. Because the ascending aorta was omitted or subtracted from the length estimation in PWV, the impact of age-related elongation of the aorta on PWV was small.


CONCLUSIONS
The aorta lengthens with age, even in healthy humans, due primarily to the elongation of the ascending aorta. Age-related aortic elongation has little impact on PWV measurements, as the ascending aorta, which undergoes lengthening with age, is not included in the arterial length measurements.
Department of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas 78712-1204, USA. jun.sugawara@mail.utexas.edu
Jun
J
Sugawara
Koichiro
K
Hayashi
Takashi
T
Yokoi
Hirofumi
H
Tanaka
D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000208:ethnology; D001011:Aorta / Q000033:anatomy & histology* / Q000502:physiology; D001027:Aortography / Q000295:instrumentation; D044466:Asian People; D001794:Blood Pressure; D002339:Carotid Arteries / Q000033:anatomy & histology; D003430:Cross-Sectional Studies; D004548:Elasticity; D005260:Female; D006801:Humans; D007083:Iliac Artery / Q000033:anatomy & histology; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007564:Japan; D018810:Magnetic Resonance Angiography / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D011673:Pulsatile Flow; D012016:Reference Values; D012039:Regional Blood Flow; D013781:Texas; D055815:Young Adult