Booster vaccination of toddlers with reduced antigen content diphtheria -- tetanus -- acellular pertussis vaccine.
Immunogenicity and reactogenicity of DTPa and reduced antigen dTpa booster vaccines were compared to a hepatitis A control vaccine in DTPa-primed toddlers aged 18 - 20 months. Post-booster, all DTPa and dTpa recipients were seroprotected against diphtheria and tetanus, and > or = 93.3% had a booster response to pertussis. There were similar reactogenicity rates in the DTPa and dTpa vaccine recipients. Few Grade 3 symptoms were reported. Just over one in four children in the control group had diphtheria antibody at or potentially below the correlate of protection benchmark (0.016IU/ml). Larger studies should evaluate potential benefits of reduced antigen vaccines and seroprotection in children who do not receive a booster dose of DTPa at this age, including protection against diphtheria until subsequent booster doses are given.
Nolan
Terry
T
Murdoch Childrens Research Institute and Melbourne School of Population Health, The University of Melbourne, Victoria, Australia. t.nolan@unimelb.edu.au
Ruff
Tilman A
TA
Lambert
Stephen B
SB
Buttery
Jim
J
O'Grady
Kerry-Ann
KA
Streeton
Catherine
C
Hoet
Bernard
B
Bock
Hans L
HL
D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000032:analysis*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000276:immunology*; D004311:Double-Blind Method; D006801:Humans; D007117:Immunization, Secondary; D007223:Infant; D016037:Single-Blind Method
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines