A multicomponent reaction of arynes, isocyanides, and terminal alkynes: highly chemo- and regioselective synthesis of polysubstituted pyridines and isoquinolines.
Many components make light work: A novel synthetic strategy for the preparation of pyridines and isoquinolines in high chemo- and regioselectivity has been developed. By manipulating the reaction conditions, either product can be generated smoothly in a highly efficient and atom-economic manner (see scheme).
Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou 310028, China.
Feng
F
Sha
Xian
X
Huang
D000480:Alkynes / Q000138:chemical synthesis*; D003486:Cyanides / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis*; D008024:Ligands; D011725:Pyridines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000480:Alkynes; D003486:Cyanides; D007546:Isoquinolines; D008024:Ligands; D011725:Pyridines