Prenatal diagnosis by 3D ultrasound and MRI of an unusual malformation of cortical development with brain-in-brain appearance.
A 31-year-old pregnant woman was referred for isolated mild ventriculomegaly and failure to visualize the left lateral ventricle's anterior horn on second trimester sonography (US). Three-dimensional US suspected a frontal lesion deviating the midline. MRI revealed a mass compressing the ventricle. Follow-up MRI described a "brain-in-brain" malformation: infolded microgyric cortex and white matter in frontal lobe extending to frontal horn and midline, irrorated by hypertophic Heubner artery. Conservative approach was chosen. Neurodevelopment at 1 year is normal.
Obstetrics and Gynaecology Department, IRCCS San Raffaele Scientific Centre, Milan, Italy.
Luca
L
Valsecchi
Paolo
P
Cavoretto
Lara
L
Di Piazza
Maddalena
M
Smid
Silvia
S
Pontesilli
Roberta
R
Scotti
Daniele
D
Spagnolo
Cristina
C
Baldoli
D000328:Adult; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000196:embryology; D002585:Cesarean Section; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D006801:Humans; D021621:Imaging, Three-Dimensional; D020547:Lateral Ventricles / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000379:methods