Cord blood survivin concentrations in human full-term normal and complicated pregnancies.
BACKGROUND
Survivin (a member of the inhibitors of apoptosis family) is important for fetal development, placental survival and differentiation. Intrauterine growth restriction (IUGR) and fetal macrosomia, due to maternal diabetes mellitus (DM) are associated with excessive and decreased feto-placental apoptosis, respectively. The aim was to study survivin concentrations in cord blood at term in IUGR, large-for-gestational-age (LGA, due to gestational DM) and appropriate-for-gestational-age (AGA) pregnancies.


METHODS
Survivin concentrations were determined in 160 mixed arterio-venous cord blood samples from IUGR (n=48), LGA (n=11) and AGA (n=101) singleton full-term infants.


RESULTS
No significant differences in survivin concentrations in cord blood were observed between groups. The effect of birthweight, customized centile, gestational age, gender, delivery mode and parity on survivin concentrations was not significant.


CONCLUSIONS
Survivin concentrations in cord blood at term are independent of intrauterine growth, gender, parity and delivery mode. Thus, they probably do not reflect the disturbances of feto-placental apoptosis expected in IUGR and fetal macrosomia due to gestational DM.
Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece. amalpu@aretaieio.uoa.gr
Ariadne
A
Malamitsi-Puchner
Stavroula
S
Baka
Maria
M
Boutsikou
Sofia
S
Liosi
Dimitrios
D
Gourgiotis
Efthimia
E
Protonotariou
Dimitrios
D
Hassiakos
Despina D
DD
Briana
D000328:Adult; D001724:Birth Weight; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005317:Fetal Growth Retardation / Q000097:blood*; D005320:Fetal Macrosomia / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008869:Microtubule-Associated Proteins / Q000097:blood*; D011247:Pregnancy; D012737:Sex Factors; D000077022:Survivin; D055815:Young Adult
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D000077022:Survivin