Polyamide amino acids: a new class of RNA ligands.
This communication introduces a new class of promising RNA ligands, named polyamide amino acids (PAA), which are able to bind a targeted bulged stem-loop RNA fragment (HIV-1 TAR RNA) with micromolar affinities and with specificity comparative to dsDNA and tRNA; both the affinity and the specificity of PAA for TAR depend on their length and on the nature of the amino acid residues.
Laboratoire de Chimie des Molécules Bioactives et des Arômes, UMR 6001 CNRS UNSA, Institut de Chimie de Nice, Université de Nice Sophia Antipolis, 06108 Nice Cedex, France.
Vanessa
V
Bonnard
Stéphane
S
Azoulay
Audrey
A
Di Giorgio
Nadia
N
Patino
D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands; D015394:Molecular Structure; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D012313:RNA / Q000737:chemistry* / Q000378:metabolism*
D000596:Amino Acids; D008024:Ligands; D009757:Nylons; D012313:RNA