Imaging of regional metabolic activity by (18)F-FDG/PET in rats with transient cerebral ischemia.
Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that (18)F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with (18)F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.
Fu
Ying-Kai
YK
Institute of Nuclear Energy Research, Tao-Yuan, Taiwan. fufrank@iner.gov.tw
Chang
Chia-Jung
CJ
Chen
Kuan-Yin
KY
Hwang
Li-Chung
LC
Wu
Kuo-Hung
KH
Chang
Kang-Wei
KW
Jan
Meei-Ling
ML
Chen
Chia-Chieh
CC
Chang
Chih-Hsien
CH
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D020244:Infarction, Middle Cerebral Artery / Q000378:metabolism*; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D049268:Positron-Emission Tomography; D051381:Rats; D017207:Rats, Sprague-Dawley
D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18