HPV variants and HLA polymorphisms: the role of variability on the risk of cervical cancer.
Human papillomavirus (HPV) infection is linked to the development of cervical cancer, and several cofactors contribute to the risk of disease. Research on the intratypic variability of HPVs has defined variants that are associated with persistent infections and are potentially more oncogenic, translating to a higher risk of malignant disease. The genetic variability of the host also plays a role in the risk of cervical cancer, especially genes controlling the immune response, such as HLA class I and II. These highly polymorphic genes are important risk determinants of HPV persistence and disease progression. The interaction between host and viral factors is complex and needs to be further investigated, paving the way to better define the patients at the highest risk of developing malignant diseases linked to HPV infection.
Division of Cellular Biology, Brazilian National Cancer Institute, R Andre Cavalcanti, 37-5o andar, 22231-090 Rio de Janeiro, Brazil. psas@inca.gov.br
Patrícia Savio
PS
de Araujo Souza
Laura
L
Sichero
Paulo Cesar
PC
Maciag
D005260:Female; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D005814:Genes, Viral; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology; D030361:Papillomavirus Infections / Q000235:genetics* / Q000276:immunology / Q000821:virology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000276:immunology / Q000821:virology*; D014764:Viral Proteins
D014764:Viral Proteins