Prognostic factors and outcomes for osteosarcoma: an international collaboration.
We aimed to evaluate the prognostic significance of traditional clinical predictors in osteosarcoma through an international collaboration of 10 teams of investigators (2680 patients) who participated. In multivariate models the mortality risk increased with older age, presence of metastatic disease at diagnosis, development of local recurrence when the patient was first seen, use of amputation instead of limb salvage/wide resection, employment of unusual treatments, use of chemotherapeutic regimens other than anthracycline and platinum and use of methotrexate. It was also influenced by the site of the tumour. The risk of metastasis increased when metastatic disease was present at the time the patient was first seen and also increased with use of amputation or unusual treatment combinations or chemotherapy regimens not including anthracycline and platinum. Local recurrence risk was higher in older patients, in those who had local recurrence when first seen and when no anthracycline and platinum were used in chemotherapy. Results were similar when limited to patients seen after 1990 and treated with surgery plus combination chemotherapy. This large-scale international collaboration identifies strong predictors of major clinical outcomes in osteosarcoma.
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece.
Emilios E
EE
Pakos
Andreas D
AD
Nearchou
Robert J
RJ
Grimer
Haris D
HD
Koumoullis
Adesegun
A
Abudu
Jos A M
JA
Bramer
Lee M
LM
Jeys
Alessandro
A
Franchi
Guido
G
Scoccianti
Domenico
D
Campanacci
Rodolfo
R
Capanna
Jorge
J
Aparicio
Marie-Dominique
MD
Tabone
Gerold
G
Holzer
Fashid
F
Abdolvahab
Philipp
P
Funovics
Martin
M
Dominkus
Inci
I
Ilhan
Su G
SG
Berrak
Ana
A
Patino-Garcia
Luis
L
Sierrasesumaga
Mikel
M
San-Julian
Moira
M
Garraus
Antonio Sergio
AS
Petrilli
Reynaldo Jesus Garcia
RJ
Filho
Carla Renata Pacheco Donato
CR
Macedo
Maria Teresa de Seixas
MT
Alves
Sven
S
Seiwerth
Rajaram
R
Nagarajan
Timothy P
TP
Cripe
John P A
JP
Ioannidis
D000293:Adolescent; D000671:Amputation, Surgical / Q000401:mortality*; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007391:International Cooperation; D023821:Limb Salvage / Q000401:mortality*; D008297:Male; D012516:Osteosarcoma / Q000401:mortality / Q000556:secondary / Q000628:therapy; D011379:Prognosis; D055815:Young Adult