Acute generalized exanthematous pustulosis: a rare clinical entity with use of piperacillin/tazobactam.
Acute generalized exanthematous pustulosis (AGEP) is a rare disorder characterized by an acute episode and sudden onset of erythematous and edematous eruptions of hundreds of sterile pustules. It is a self-limiting condition accompanied by fever and has a rapid course. It is mostly caused by drugs especially antibiotics. It is diagnosed by skin biopsy, which shows intracorneal pustules and neutrophilic infiltration in dermis and epidermis. We report a case of a patient who developed this rare skin condition with the use of piperacillin/tazobactam (Zosyn). This is only second case of AGEP reported in literature with the use of Zosyn.
Talati
Sapan
S
Department of Internal Medicine, Long Island College Hospital, New York, NY, USA. stalati@chpnet.org
Lala
Moin
M
Kapupara
Hiteshkumar
H
Thet
Zeyar
Z
D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002481:Cellulitis / Q000188:drug therapy; D004338:Drug Combinations; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D010397:Penicillanic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010878:Piperacillin / Q000009:adverse effects* / Q000627:therapeutic use; D000078142:Tazobactam
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin