Racial differences in the impact of comorbidities on survival among elderly men with prostate cancer.
This study investigates differences in the effects of comorbidities on survival in Medicare beneficiaries with prostate cancer. Medicare data were used to assemble a cohort of 65- to 76-year-old Black (n = 6,402) and White (n = 47,458) men with incident localized prostate cancer in 1999 who survived >or=1 year postdiagnosis. Comorbidities were more prevalent among Blacks than among Whites. For both races, greater comorbidity was associated with decreasing survival rates; however, the effect among Blacks was smaller than in Whites. After adjusting for age, socioeconomic status, and community characteristics, the association between increasing comorbidities and survival remained weaker for Blacks than for Whites, and racial disparity in survival decreased with increasing number of comorbidities. Differential effects of comorbidities on survival were also evident when examining different classes of comorbid conditions. Adjusting for treatment had little impact on these results, despite variation in the racial difference in receipt of prostatectomy with differing comorbidity levels.
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia 19104, USA.
Mary
M
Putt
Judith A
JA
Long
Chantal
C
Montagnet
Jeffrey H
JH
Silber
Virginia W
VW
Chang
Kaijun Liao
J Sanford
JS
Schwartz
Craig Evan
CE
Pollack
Yu-Ning
YN
Wong
Katrina
K
Armstrong
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044383:Black People / Q000706:statistics & numerical data*; D015331:Cohort Studies; D015897:Comorbidity; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D006278:Medicare; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D016016:Proportional Hazards Models; D011471:Prostatic Neoplasms / Q000208:ethnology* / Q000401:mortality; D012189:Retrospective Studies; D012959:Socioeconomic Factors; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data*; D001741:Black or African American