[Changes in oxidative stress biomarkers induced by puberty].
OBJECTIVE
Evaluate the influence of puberty in oxidative stress.


METHODS
The study included 38 prepubescent males with Tanner G(1)-P(1) and 32 healthy pubescent boys with Tanner G(3-4)-P(3-4). Weight, height and body mass index, heart rate, blood pressure values were within the 50 percentile 50+/-1SD for their age. The biomarkers were measured in saliva, as a good correlation between saliva and plasma levels has been reported in lipoperoxidation products, reduced glutathione and catalase.


RESULTS
Pubescent boys had significantly higher levels of lipoperoxidation products (P<0.001) compared with the prepubertal group, with no significant differences in the other parameters measured. There was a significant positive correlation between lipoperoxides and reduced glutathione in these children.


CONCLUSIONS
It is the first time that an increase of lipoperoxidation products has been reported in pubertal boys and this biomarker could play a role in the development of oxidative stress in this stage of life.
Departamento de Pediatría, Hospital Universitario Reina Sofía, Facultad de Medicina, Universidad de Córdoba, Córdoba, España.
J L
JL
Pérez-Navero
J D
JD
Benítez-Sillero
M
M
Gil-Campos
M
M
Guillén-del Castillo
I
I
Tasset
I
I
Túnez
D000293:Adolescent; D002648:Child; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D011627:Puberty / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry