Drug confinement and delivery in ceramic implants.
Ordered silica-based mesoporous materials could be specially designed and chemically modified for the adsorption of drugs that would be locally released. The drug adsorption and release kinetics are controlled by several factors such as pore size, volume, architecture and chemistry of the silica walls.
Vallet-Regí
María
M
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, E-28040-Madrid, Spain. vallet@farm.ucm.es
Balas
Francisco
F
Colilla
Montserrat
M
Manzano
Miguel
M
D000327:Adsorption; D000818:Animals; D001861:Bone Regeneration; D002516:Ceramics / Q000737:chemistry*; D016503:Drug Delivery Systems; D004343:Drug Implants / Q000737:chemistry; D006801:Humans; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
D004343:Drug Implants; D012822:Silicon Dioxide