DNA sequence polymorphism analysis using DnaSP.
The analysis of DNA sequence polymorphisms and SNPs (single nucleotide polymorphisms) can provide insights into the evolutionary forces acting on populations and species. Available population-genetic methods, and particularly those based on the coalescent theory, have become the primary framework to analyze such DNA polymorphism data. Here, I explain some essential analytical methods for interpreting DNA polymorphism data and also describe the basic functionalities of the DnaSP software. DnaSP is a multi-propose program that allows conducting exhaustive DNA polymorphism analysis using a graphical user-friendly interface.
Rozas
Julio
J
Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D011110:Polymorphism, Genetic / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D014584:User-Computer Interface