Carotid stiffness and microalbuminuria in patients with type 2 diabetes.
Microalbuminuria is associated with higher cardiovascular mortality, especially in diabetics. But the direct association between microalbuminuria and vascular wall properties is still not clear. We investigated quantitative carotid stiffness (QCS) index in relation to microalbuminuria in 260 Chinese diabetic patients. In categorical analyses, patients with elevated urinary albumin-to-creatinine ratio (uACR) had higher QCS than those with normal uACR (P < 0.001). The corresponding values for QCS values were 4.4 and 5.9, respectively. In multiple stepwise regression analyses, QCS was significantly associated with age, uACR, plasma glycosylated hemoglobin A(1C) (HbA(1C)), and current smoking (P < 0.05 for all). In conclusion, carotid stiffness as measured by QCS, a local functional measurement of the arterial wall, is increased in type 2 diabetes with microalbuminuria.
Zhan
Wei-Wei
WW
Department of Ultrasonography, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200025, People's Republic of China.
Chen
Yu-Hong
YH
Zhang
Yi-Fei
YF
Zhu
Ying
Y
Lin
Yan-Yan
YY
Ren
Xin-Ping
XP
Li
Xiao-Ying
XY
Liu
Yan-Ping
YP
D000419:Albuminuria / Q000150:complications*; D050197:Atherosclerosis / Q000175:diagnosis / Q000209:etiology; D001794:Blood Pressure; D017536:Carotid Artery, Common / Q000503:physiopathology*; D003404:Creatinine / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014664:Vasodilation / Q000502:physiology
D003404:Creatinine