Direct alkylative Passerini reaction of aldehydes, isocyanides, and free aliphatic alcohols catalyzed by indium(III) triflate.
In(OTf)(3) was found to be a useful Lewis acid catalyst for direct alkylative Passerini reaction of aldehydes, isocyanides, and free aliphatic alcohols. In the present reaction, aromatic and alpha,beta-unsaturated aldehydes performed as nice substrates to give the corresponding alpha-alkoxy amide products in good yield.
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Hikaru
H
Yanai
Tomoko
T
Oguchi
Takeo
T
Taguchi
D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*
D000438:Alcohols; D000447:Aldehydes; D003486:Cyanides; D008698:Mesylates; C012077:trifluoromethanesulfonic acid