Haloperidol for the treatment of nausea and vomiting in palliative care patients.
BACKGROUND
Nausea and vomiting are common symptoms of patients with terminal, incurable illnesses and can be distressing.


OBJECTIVE
The primary objective of the review was to evaluate the efficacy and adverse events associated with the use of haloperidol for the treatment of nausea and vomiting in palliative care patients.


METHODS
Several electronic databases were searched including CENTRAL, MEDLINE, EMBASE, CINAHL and AMED, using relevant search terms and synonyms. Handsearching complemented electronic searches (using reference lists of included studies, relevant chapters and review articles). There were no language restrictions imposed. Database searching was performed between 2nd and 16th September 2007.


METHODS
Studies considered for inclusion were randomised controlled trials (RCTs) of haloperidol for the treatment of nausea or vomiting, or both, in any setting. The studies had to be conducted with adults receiving palliative care or suffering from an incurable progressive medical condition. Studies where nausea or vomiting, or both, thought to be secondary to pregnancy or surgery were excluded.


METHODS
Records from each of the electronic databases were imported into a bibliographic package and merged into a core database where titles, keywords and abstracts were inspected for relevance. If it was not possible to accept or reject an abstract with certainty, the full text of the article was obtained for further evaluation. The two review authors independently assessed studies in accordance with the inclusion criteria. There were no differences in opinion between authors with regard to assessment of studies.


RESULTS
No RCTs were identified meeting the inclusion criteria. Twenty-six studies were considered but all were excluded from the review.


CONCLUSIONS
We did not identify any RCTs exploring the effectiveness of haloperidol for nausea and vomiting in palliative care patients.
Sue Ryder Care Leckhampton Court Hospice, Church Road, Leckhampton, Cheltenham, Gloucestershire, UK, GL53 0QJ. paul.perkins@suerydercare.org
Paul
P
Perkins
Saskie
S
Dorman
D000932:Antiemetics / Q000627:therapeutic use*; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D009325:Nausea / Q000188:drug therapy*; D010166:Palliative Care; D014839:Vomiting / Q000188:drug therapy*
D000932:Antiemetics; D006220:Haloperidol