Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study.
BACKGROUND
The Cytochrome P-4501A1 (CYP1A1) gene, located on chromosome 15q, is involved in the metabolism of carcinogens mainly polycyclic aromatic hydrocarbons as well as estrogen. It is considered as candidate gene for low-penetrance breast cancer susceptibility. Hence the present study aims to discuss the role of CYP1A1 polymorphisms in breast cancer.


METHODS
A total of 250 breast cancer patients and the same number of healthy age-matched controls were analyzed for the polymorphism of CYP1A1*2 by polymerase chain reaction-restriction fragment length polymorphism.


RESULTS
In the present study, association of CYP1A1*2 (Ile 462Val) polymorphism with breast cancer was studied. Only one breast cancer patient was observed to be homozygous for Val allele but none among controls. The frequency of heterozygous Ile/Val genotype was found to be increased significantly in breast cancer patients (68.1%) as compared to controls (51.0%). Higher frequency of heterozygotes for Val allele was observed among premenopausal breast cancer patients and patients with high BMI, positive for HER2/neu status and advanced stage of the disease in comparison to the corresponding groups. No significant association of CYP1A1*2 polymorphism was observed with occupation, estrogen receptor and progesterone receptor status of breast cancer patients.


CONCLUSIONS
In conclusion, our results suggest a significant correlation between CYP1A1*2 expression and the occurrence of breast cancer.
Surekha
D
D
Department of Genetics, Osmania University, Hyderabad, India.
Sailaja
K
K
Rao
D Nageswara
DN
Padma
T
T
Raghunadharao
D
D
Vishnupriya
S
S
D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics; D018570:Risk Assessment
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D019388:Cytochrome P-450 CYP1A2