Enteric bacterial pathogens in HIV-infected children with acute diarrhea in Mulago referral and teaching hospital, Kampala, Uganda.
OBJECTIVE
HIV-infected children develop severe bacterial infections. We set out to determine the enteric bacterial pathogens in HIV-infected children and HIV-negative controls with acute diarrhea and their antimicrobial sensitivities.


METHODS
Children below 5 years of age with acute diarrhea were screened for HIV and their stools were analyzed by culture and use of antisera and the sensitivities of the pathogens were determined using the Kirby Bauer disc diffusion method.


RESULTS
Of the 190 children, 47 were HIV positive. The prevalence rates of the pathogens in HIV-infected and -uninfected children were 19% (9/47) and 27% (38/143), respectively; odds ratio = 0.64 (95% confidence interval 0.20-1.97), P value .396. The pathogens in HIV-infected and -uninfected children were Escherichia coli, Salmonella, and Shigella species. Most isolates were resistant to cotrimoxazole.


CONCLUSIONS
Escherichia coli, Salmonella, and Shigella species significantly cause acute diarrhea in HIV-infected and -uninfected children and they are highly resistant to cotrimoxazole.
Musiime
Victor
V
Joint Clinical Research Centre, Clinic, Kampala, Uganda. musiimev@yahoo.co.uk
Kalyesubula
Israel
I
Kaddu-Mulindwa
Deogratius
D
Byarugaba
Justus
J
D000890:Anti-Infective Agents / Q000494:pharmacology; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003967:Diarrhea / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D004755:Enterobacteriaceae / Q000187:drug effects / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006784:Hospitals, Teaching; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology; D014454:Uganda / Q000453:epidemiology
D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination