Involvement of cytochromes P450 2D6, 2B6 and 2C19 in the metabolism of (-)-deprenyl and N-methyl,N-propargylphenylethylamine.
The metabolism of (-)-deprenyl (N-methyl,N-propargylamphetamine) and N-methyl,N-propargylphenyl-ethylamine (MPPE), monoamine oxidase inhibitors with neuroprotective properties, was studied using human liver microsomes and cDNA-expressed cytochrome P450 (CYP) enzymes. The metabolic pathways of MPPE parallel those of (-)-deprenyl, but some marked differences were observed, particularly with regard to the contributions of CYP2B6 and CYP2D6.
Neurochemical Research Unit, Department of Psychiatry, 1E7 Mackenzie Centre, University of Alberta, Edmonton, Alberta, Canada.
K A
KA
Rittenbach
G B
GB
Baker
D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D065702:Cytochrome P-450 CYP2B6; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism*; D018076:DNA, Complementary; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism; D018696:Neuroprotective Agents / Q000378:metabolism; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D012642:Selegiline / Q000031:analogs & derivatives* / Q000378:metabolism
D018076:DNA, Complementary; D008996:Monoamine Oxidase Inhibitors; C508639:N-Methyl,N-propargyphenylethylamine; D018696:Neuroprotective Agents; D012642:Selegiline; D001189:Aryl Hydrocarbon Hydroxylases; C585599:CYP2B6 protein, human; C045793:CYP2C19 protein, human; D065702:Cytochrome P-450 CYP2B6; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6; D010089:Oxidoreductases, N-Demethylating