LS-SNP/PDB: annotated non-synonymous SNPs mapped to Protein Data Bank structures.
CONCLUSIONS
LS-SNP/PDB is a new WWW resource for genome-wide annotation of human non-synonymous (amino acid changing) SNPs. It serves high-quality protein graphics rendered with UCSF Chimera molecular visualization software. The system is kept up-to-date by an automated, high-throughput build pipeline that systematically maps human nsSNPs onto Protein Data Bank structures and annotates several biologically relevant features.


BACKGROUND
LS-SNP/PDB is available at (http://ls-snp.icm.jhu.edu/ls-snp-pdb) and via links from protein data bank (PDB) biology and chemistry tabs, UCSC Genome Browser Gene Details and SNP Details pages and PharmGKB Gene Variants Downloads/Cross-References pages.
Ryan
Michael
M
Department of Bioinformatics, George Mason University, Fairfax, VA, USA.
Diekhans
Mark
M
Lien
Stephanie
S
Liu
Yun
Y
Karchin
Rachel
R
D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D030562:Databases, Protein / Q000592:standards; D006801:Humans; D020407:Internet; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000737:chemistry*; D020539:Sequence Analysis, Protein; D012984:Software; D014584:User-Computer Interface
D011506:Proteins