Novel inhibitors of HIV discovered among existing classes of pharmaceutical compounds indicated for unrelated clinical indications.
In vitro screening of 307 drugs with various clinical indications (cardiotropic, neurotropic, antibacterial, etc.) has revealed 6 compounds which displayed remarkable antiretroviral activity. Three of these drugs had a tendency to have undesirable side effects and were thus excluded from further consideration. Remaining three, i.e., Xantinol Nicotinate, Tardiferon, and Trental may become valid candidates for inclusion into antiviral regimens such as HAART. In vitro tests have shown that xantinol and trental display synergistic effect with azidothymidine, inhibit the replication AZT-resistant strains of HIV, and have no competing undesirable activities. These compounds should be evaluated in safety studies to determine optimal doses for patients with HIV. If these studies confirm in vitro results these compounds may become valid candidates as safe and affordable means to be added into the arsenal of antiretroviral drugs.
State Scientific Research Institute of Epidemiology and Microbiology, Ministry of Health of Belarus, Minsk, Belarus.
I I
II
Kucherov
P G
PG
Rytik
I A
IA
Podol'skaya
L O
LO
Mistryukova
M O
MO
Korjev
D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004338:Drug Combinations; D005296:Ferrous Compounds; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D009077:Mucins; D010431:Pentoxifylline; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014971:Xanthinol Niacinate
D019380:Anti-HIV Agents; D004338:Drug Combinations; D005296:Ferrous Compounds; D009077:Mucins; D014665:Vasodilator Agents; C009380:ferrous sulfate, mucin drug combination; D014971:Xanthinol Niacinate; D010431:Pentoxifylline