Two titanium-catalyzed reaction sequences for syntheses of pyrroles from (E/Z)-chloroenynes or alpha-haloalkynols.
Titanium-catalyzed intermolecular hydroaminations of (E/Z)-chloroenynes enabled an efficient pyrrole synthesis, which set the stage for the development of a user-friendly one-pot reaction for the regioselective preparation of fully substituted pyrroles from easily accessible alpha-haloalkynols.
Ackermann
Lutz
L
Institut für Organische and Biomolekulare Chemie, Georg-August-Universitaet, Tammannstrasse 2, 37077 Goettingen, Germany. lutz.ackermann@chemie.uni-goettingen.de
Sandmann
René
R
Kaspar
Ludwig T
LT
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
D000480:Alkynes; D006843:Hydrocarbons, Chlorinated; D011758:Pyrroles; D014025:Titanium