Osthole: a promising lead compound for drug discovery from a traditional Chinese medicine (TCM).
Natural products have always been important resources either as therapeutic agents or as lead compounds for the production of pharmaceutical compounds. Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, an ingredient of a Traditional Chinese Medicine(TCM), has received considerable attention recently because of its significant and diverse pharmacological activities, including anticancer, antisteoporotic, and antiproliferative, which make it a very promising natural lead compound for new drug discovery. The present work summarizes the related biological information on osthole and its analogues and proposes the possibility of its development as a promising lead compound for drug discovery.
School of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China. youlisha@shutcm.com
Lisha
L
You
Song
S
Feng
Rui
R
An
Xinhong
X
Wang
D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D055808:Drug Discovery; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008516:Medicine, Chinese Traditional; D008967:Molecular Biology
D003374:Coumarins; D004365:Drugs, Chinese Herbal; C046627:osthol