Four-component reaction for the preparation of alpha-amino phosphonates from methyleneaziridines.
Alpha-amino phosphonates can be rapidly assembled in moderate to good yields (42-65%) via a "one-pot" process that brings together four components through the construction of three new intermolecular bonds.
Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom.
Peter M
PM
Mumford
Gary J
GJ
Tarver
Michael
M
Shipman
D001388:Aziridines / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry*
D001388:Aziridines; D063065:Organophosphonates