The strategy for prevention of measles and rubella prevalence with measles-rubella (MR) vaccine in Japan.
To eliminate the indigenous measles and rubella virus by 2012 in Japan, the strategy fro prevention of measles and rubella prevalence with measles-rubella (MR) vaccine was proposed. Since the vast majority of 1-year old infants are susceptible to measles and rubella, the first MR vaccine, the first MR vaccine should be administered at 1-year old to sustain the herd immunity. Since significant elevation of measles and rubella antibody titers were eliminated in a half of children after the second dose, the second dose of of MR vaccine within 1 year before elementary school entry is the effective maneuver. Moreover, supplement MR vaccination to the teenage group and 20-29 years' group might be necessary, because the mean measles antibody titers in this group were significantly lower compared with those in the older individuals' groups.
Ihara
Toshiaki
T
Department of Pediatrics, National Hospital Organization Mie National Hospital, Mie, Japan. ihara@mie-m.hosp.go.jp
D006801:Humans; D007564:Japan / Q000453:epidemiology; D008457:Measles / Q000453:epidemiology / Q000517:prevention & control*; D008458:Measles Vaccine / Q000276:immunology; D015995:Prevalence; D012409:Rubella / Q000453:epidemiology / Q000517:prevention & control*; D012411:Rubella Vaccine / Q000276:immunology; D017778:Vaccines, Combined / Q000276:immunology
D008458:Measles Vaccine; D012411:Rubella Vaccine; D017778:Vaccines, Combined