Inhibition of selenium metabolism in the oral pathogen Treponema denticola.
In this report we provide evidence that the antimicrobial action of stannous salts and a gold drug, auranofin, against Treponema denticola is mediated through inhibition of the metabolism of selenium for synthesis of selenoproteins.
Department of Molecular Biology and Microbiology, Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL 32816-2364, USA.
Sarah
S
Jackson-Rosario
William T
WT
Self
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001310:Auranofin / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism; D015536:Down-Regulation; D006801:Humans; D009059:Mouth Diseases / Q000382:microbiology*; D012643:Selenium / Q000378:metabolism*; D051140:Selenoproteins / Q000378:metabolism; D017971:Tin Compounds / Q000494:pharmacology; D048373:Treponema denticola / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D014211:Treponemal Infections / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D051140:Selenoproteins; D017971:Tin Compounds; D001310:Auranofin; D012643:Selenium