Photoregulated release of caged anticancer drugs from gold nanoparticles.
An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.
Agasti
Sarit S
SS
Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
Chompoosor
Apiwat
A
You
Chang-Cheng
CC
Ghosh
Partha
P
Kim
Chae Kyu
CK
Rotello
Vincent M
VM
D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005472:Fluorouracil / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D010777:Photochemistry; D011827:Radiation; D013499:Surface Properties; D014466:Ultraviolet Rays
D000964:Antimetabolites, Antineoplastic; D004337:Drug Carriers; D006046:Gold; D005472:Fluorouracil