Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species.
Pregnane glycosides previously isolated from genus Caralluma (C. Penicillata, C. tuberculata and C. russelliana) were tested for their antitrypanosomal activity. Penicilloside E showed the highest antitrypanosomal activity (IC(50) 1.01 microg/ml) followed by caratuberside C (IC(50) 1.85 microg/ml), which exhibited the highest selectivity index (SI 12.04). It was noticed that acylation is required for the antitrypanosomal activity while glycosylation at C-20 has no significant effect on the activity.
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. abdelsattar@yahoo.com
Essam
E
Abdel-Sattar
Naglaa G
NG
Shehab
Chikara
C
Ichino
Hiroaki
H
Kiyohara
Aki
A
Ishiyama
Kazuhiko
K
Otoguro
Satoshi
S
Omura
Haruki
H
Yamada
D000215:Acylation; D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D002240:Carbohydrate Sequence; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D006031:Glycosylation; D006801:Humans; D008969:Molecular Sequence Data; D011278:Pregnanes / Q000737:chemistry / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects
D006027:Glycosides; D011278:Pregnanes; D014344:Trypanocidal Agents