Efficient method for the synthesis of pyranoquinoline, thiopyranoquinoline, thienoquinoline, and naphtho[2,7]naphthyridine derivatives catalyzed by iodine.
A mild and efficient method for the synthesis of pyranoquinoline, thiopyranoquinoline, thienoquinoline, and naphtho[2,7]naphthyridine derivatives via three-component reaction of aromatic aldehyde, naphthalen-2-amine, and heterocycloketones, including tetrahydropyran-4-one, tetrahydrothiopyran-4-one, pyridinone, and thiophenone, is described using iodine as catalyst. The features of this procedure are mild reaction conditions, good to high yields, and operational simplicity.
School of Chemistry and Chemical Engineering, Xuzhou Normal University, The Key Laboratory of Biotechnology on Medical Plant, Xuzhou Jiangsu 221116, PR China. xswang1974@yahoo.com
Xiang-Shan
XS
Wang
Qing
Q
Li
Jian-Rong
JR
Wu
Shu-Jiang
SJ
Tu
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D007455:Iodine / Q000737:chemistry*; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
D009287:Naphthyridines; D011714:Pyrans; D011804:Quinolines; D007455:Iodine