(R)-lipo-diaza-18-crown-6 self-assembled monolayer as a selective serotonin receptor.
A highly selective receptor for serotonin was designed using cages formed by the (R)-lipo-diaza-18-crown-6 self-assembled monolayer (SAM) on gold and experimentally verified by a variety of electrochemical experiments in solutions containing large amounts of dopamine and ascorbic acid, as well as other interferents. The molecular modeling study showed that parameters such as the H-pi interaction provided important driving forces for the cage to form a strong inclusion complex with serotonin. The charge-transfer resistance (R(CT)'s) to/from redox probe ions, Fe(CN)(6)(3-/4-), was greatly enhanced because of their electrostatic attractions to ammonium ions of serotonin molecules captured by cages. The changes in R(CT)-values were shown to be remarkably selective for serotonin in the presence of many interferents.
Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Korea.
Jin-Young
JY
Park
Yoon-Suk
YS
Lee
Byoung-Yong
BY
Chang
S
S
Karthikeyan
Kwang S
KS
Kim
Byeang Hyean
BH
Kim
Su-Moon
SM
Park
D043844:Crown Ethers / Q000737:chemistry; D055664:Electrochemical Techniques; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D010084:Oxidation-Reduction; D011985:Receptors, Serotonin / Q000378:metabolism*; D008063:Thioctic Acid / Q000737:chemistry
D043844:Crown Ethers; D011985:Receptors, Serotonin; C015762:18-crown-6; D008063:Thioctic Acid; D006046:Gold