A common variant on chromosome 11q13 is associated with atopic dermatitis.
We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P(combined) = 7.6 x 10(-10)). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.
Pediatric Pneumology and Immunology, Charité Universitätsmedizin Berlin, Germany.
Jorge
J
Esparza-Gordillo
Stephan
S
Weidinger
Regina
R
Fölster-Holst
Anja
A
Bauerfeind
Franz
F
Ruschendorf
Giannino
G
Patone
Klaus
K
Rohde
Ingo
I
Marenholz
Florian
F
Schulz
Tamara
T
Kerscher
Norbert
N
Hubner
Ulrich
U
Wahn
Stefan
S
Schreiber
Andre
A
Franke
Rainer
R
Vogler
Simon
S
Heath
Hansjörg
H
Baurecht
Natalija
N
Novak
Elke
E
Rodriguez
Thomas
T
Illig
Min-Ae
MA
Lee-Kirsch
Andrzej
A
Ciechanowicz
Michael
M
Kurek
Tereza
T
Piskackova
Milan
M
Macek
Young-Ae
YA
Lee
Andreas
A
Ruether
D000293:Adolescent; D016022:Case-Control Studies; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult