[Evaluation of stomatognathic system in BRCA1 gene mutation carriers before and after prophylactic adnexectomy--part I: evaluation of stomatognathic system in youth BRCA1 gene mutation carriers].
BACKGROUND
Identification of abnormalities of stomatognathic organ can be useful in diagnostics of genetic disorders including genetic syndromes with predisposition to malignancy. Until now, no studies have been performed in order to find whether BRCA1 gene mutation might correlate with stomatognathic abnormalities. The aim of the study was to evaluate whether any characteristic changes within masticatory system may be found in healthy BRCA1 gene mutation carriers.


METHODS
Thirty BRCA1 gene female mutation carriers aged 21-39 years, citizens of Szczecin, have been studied. The studied women were healthy patients of the Hereditary Cancer Center, Szczecin, Poland, who never underwent any chemoprevention or prophylactic adnexectomy. The control group constituted 60 healthy, age-matched, randomly selected females from general practitioner offices of the Szczecin Shipyard Outpatient Department "Porta Medyk Sp. z o.o.". The complete dental exam was performed in all studied women. Additionally, panoramic radiograms were performed.


RESULTS
The significant differences between studied and control groups have been found in the frequency of malocclusion and in the status of periodontium. Significantly more sextants with periodontal pockets 4-5 mm deep were found in the group of patients with mutation than in the control group. The incidence of moderate and severe malocclusion was more than twofold lower in the BRCA1 group when compared with the control group.


CONCLUSIONS
It supports conclusion that incidence of moderate and severe malocclusion is at least not increased among BRCA1 carriers. For the rest of the studied parameters significant differences between studied and control groups were not found.
Chruściel-Nogalska
Małgorzata
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Zakład Protetyki Stomatologicznej Pomorskiej Akademii Medycznej w Szczecinie al. Powstańców Wlkp. 72, 70-111 Szczecin.
D000328:Adult; D015897:Comorbidity; D005260:Female; D019398:Genes, BRCA1; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D008310:Malocclusion / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics*; D009154:Mutation; D010052:Ovariectomy; D010375:Pedigree; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics; D011859:Radiography