Nilotinib inhibits the Src-family kinase LCK and T-cell function in vitro.
Blake
Stephen J
SJ
Lyons
A Bruce
AB
Hughes
Timothy P
TP
D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors*; D010835:Phytohemagglutinins / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology*
D010835:Phytohemagglutinins; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); C498826:nilotinib