Electrochemotherapy compared to surgery for treatment of canine mast cell tumours.
The aim of this study was to evaluate the effectiveness of local treatment electrochemotherapy (ECT) with cisplatin and to compare it with effectiveness of surgery for treatment of mast cell tumours (MCT) in dogs.


METHODS
In the present retrospective study, 25 dogs of different breeds with MCT were divided into two treatment groups: surgery (16 dogs with 16 tumours) and those whose owners refused surgery being included into the ECT group (9 dogs with 12 tumours). Response rate and duration of response to the treatment were evaluated and comparison between groups was made.


RESULTS
The clinical stages of the tumours were stage I in 4 (45%) and stage III in 5 (55%) dogs treated by ECT; 12 (75%) dogs treated by surgery were stage I and 4 (25%) dogs were in clinical stage III. The median size of the tumours was 5.2 cm3 and 2.9 cm3 of tumours treated by surgery and ECT, respectively. ECT resulted in as comparable antitumor effectiveness as surgical treatment. However, the estimated median duration of response in dogs treated with complete surgical excision was 31.5 months, while it was not reached for the ECT group at the time of writing.


CONCLUSIONS
ECT is an easy, effective and safe local treatment of MCT. It can be an alternative treatment to surgery, specifically for smaller nodules in which a complete response with long duration can be obtained after only one treatment session, or when the nodule is unresectable because of the location.
Janssen-Cilag, Division of Johnson-Johnson, Ljubljana, Slovenia.
Veronika
V
Kodre
Maja
M
Cemazar
Jani
J
Pecar
Gregor
G
Sersa
Andrej
A
Cor
Natasa
N
Tozon
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery*; D004285:Dogs; D053672:Electrochemotherapy / Q000662:veterinary*; D018274:Electroporation / Q000662:veterinary; D005260:Female; D008297:Male; D034801:Mastocytoma / Q000628:therapy / Q000662:veterinary*; D009367:Neoplasm Staging / Q000662:veterinary; D012074:Remission Induction; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000628:therapy / Q000662:veterinary*
D000970:Antineoplastic Agents; D002945:Cisplatin