PH of medicated syrups--does it really matter?--an in-vitro study: Part-II.
The aim of the present in vitro study was to quantify the endogenous erosive potential of the various pediatric liquid medicaments by measuring the calcium dissolution of primary enamel after immersing it for different time intervals (1 min, 10 min and 8 hours) using atomic absorption spectrometer (AAS). The eight commonly used pediatric liquid medicaments which were selected had definitive endogenous calcium dissolution potential. All the medicaments showed calcium dissolution of primary enamel at alkaline pH and near neutral pH. The calcium dissolution potential of pediatric liquid medicaments when compared with their respective pH showed no statistically significant correlation. In conclusion, there was evidence of calcium dissolution from all the pediatric liquid medicaments.
Department of Pedodontics and Preventive Dentistry, The Oxford Dental College, Hospital and Research Centre, Hosur Road, Bangalore-68, Karnataka, India. drgirish77@yahoo.com
K L Girish
KL
Babu
Kavita
K
Rai
Amitha M
AM
Hegde
D002118:Calcium / Q000737:chemistry; D002648:Child; D002675:Child, Preschool; D003743:Dental Enamel / Q000187:drug effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000737:chemistry; D014677:Pharmaceutical Vehicles; D018709:Statistics, Nonparametric; D017001:Tooth Demineralization / Q000139:chemically induced; D014077:Tooth Erosion / Q000139:chemically induced*; D014094:Tooth, Deciduous / Q000187:drug effects*
D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles; D002118:Calcium