Clear cell sarcoma of the stomach.
Clear cell sarcoma (CCS) is a high grade soft tissue sarcoma with a distinct molecular profile. Gastrointestinal CCS is very rare and most reported cases are in adults. We describe a 10-year-old female with a 4-month history of anemia who later developed fever, weight loss and abdominal pain. She was subsequently found to have a large infiltrative gastric mass. A diagnosis of CCS was confirmed by molecular and cytogenetic studies. This case illustrates the necessity of a multimodal approach, particularly the use of molecular studies, in the diagnostic evaluation of rare tumors presenting in unusual sites.
Lagmay
Joanne P
JP
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA. lagmayj@chi.osu.edu
Ranalli
Mark
M
Arcila
Maria
M
Baker
Peter
P
D000971:Antineoplastic Combined Chemotherapy Protocols; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005743:Gastrectomy; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011878:Radiotherapy; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018227:Sarcoma, Clear Cell / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D014157:Transcription Factors / Q000235:genetics
C111598:EWS-ATF1 fusion protein, human; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors