Molecular diversification in the quorum-sensing system of Vibrio cholerae: Role of natural selection in the emergence of pandemic strains.
Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described: hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.
Department of Ecology and Environmental Science, Umeå University, Sweden. nina.talyzina@emg.umu.se
Nina M
NM
Talyzina
Pär K
PK
Ingvarsson
Jun
J
Zhu
Sun N
SN
Wai
Agneta
A
Andersson
D001426:Bacterial Proteins / Q000235:genetics*; D002771:Cholera / Q000453:epidemiology / Q000382:microbiology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004196:Disease Outbreaks; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D010802:Phylogeny; D011110:Polymorphism, Genetic; D053038:Quorum Sensing; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D041241:Vibrio cholerae O1 / Q000235:genetics / Q000502:physiology*; D041242:Vibrio cholerae O139 / Q000235:genetics / Q000502:physiology*; D044163:Vibrio cholerae non-O1 / Q000235:genetics / Q000502:physiology*
D001426:Bacterial Proteins; D004269:DNA, Bacterial