Schwannoma with monoclonal plasma cell infiltration.
The authors report a very rare case of a vestibular schwannoma with an infiltrate of monoclonal plasma cells. A 45-year-old woman underwent routine excision of a presumed vestibular schwannoma. Histological analysis revealed the presence of a distinct lambda light chain restricted plasma cell population within the schwannoma. The light chain restriction and polymerase chain reaction-demonstrated monoclonality of the plasma cell population suggested the co-occurrence of a plasma cell neoplasm within a schwannoma. A search for systemic disease of plasma cell origin was unremarkable. A search of the literature suggests that this is the first report of such an occurrence.
Department of Neurosurgery, Royal Free Hospital, London, UK. joshuaplaut@googlemail.com
Joshua
J
Plaut
Malcolm
M
Galloway
Anna
A
Childerhouse
Robert
R
Bradford
D005260:Female; D006801:Humans; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology*