Prophylactic effect of administration of human gamma globulins in a mouse model of tuberculosis.
The protective effect of human gamma globulins on Mycobacterium tuberculosis infection was evaluated in a mouse model of intratracheal infection. Animals receiving human gamma globulins intranasally, 2h before intratracheal challenge showed a significant decrease in lung bacilli load compared to non-treated animals in different time intervals of up to 2 months after challenge. The same effect was obtained when M. tuberculosis was pre-incubated with the gamma globulin before challenge. The protective effect of the gamma-globulin formulation was abolished after pre-incubation with M. tuberculosis. These results suggest a potential role of specific antibodies in the defence against mycobacterial infections.
Department of Molecular Biology, Finlay Institute, Ave 27 No. 19805, La Lisa, Havana City, AP 16017, CP 11600, Cuba.
Nesty
N
Olivares
Alina
A
Puig
Diana
D
Aguilar
Aniel
A
Moya
Armando
A
Cádiz
Oscar
O
Otero
Luis
L
Izquierdo
Gustavo
G
Falero
Rosa L
RL
Solis
Hector
H
Orozco
Maria E
ME
Sarmiento
Mohd Nor
MN
Norazmi
Rogelio
R
Hernández-Pando
Armando
A
Acosta
D000281:Administration, Intranasal; D000818:Animals; D015169:Colony Count, Microbial; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification; D014397:Tuberculosis, Pulmonary / Q000382:microbiology / Q000517:prevention & control*; D005719:gamma-Globulins / Q000008:administration & dosage* / Q000276:immunology
D007155:Immunologic Factors; D005719:gamma-Globulins