RuvB-like protein 2 is a suppressor of influenza A virus polymerases.
In pro- and eukaryotic cells, RuvB-like protein 2 (RBL2) resolves Holliday junction recombination intermediates. Here, we identified RBL2 as a suppressor of influenza A virus replication. Human RBL2 appears to interfere with the oligomerization of the viral nucleoprotein, a critical step in the assembly of viral replication complexes.
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokaneda, Minato-ku, Tokyo 108-8639, Japan.
Satoshi
S
Kakugawa
Masayuki
M
Shimojima
Gabriele
G
Neumann
Hideo
H
Goto
Yoshihiro
Y
Kawaoka
D000074183:ATPases Associated with Diverse Cellular Activities; D002352:Carrier Proteins / Q000378:metabolism*; D002460:Cell Line; D004265:DNA Helicases / Q000378:metabolism*; D015967:Gene Expression Regulation, Viral; D055785:Gene Knockdown Techniques; D006801:Humans; D009980:Influenza A virus / Q000201:enzymology* / Q000502:physiology; D019590:Nucleocapsid Proteins; D055503:Protein Multimerization; D012367:RNA, Viral / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012324:RNA-Dependent RNA Polymerase / Q000378:metabolism*; D014758:Viral Core Proteins / Q000378:metabolism*; D014779:Virus Replication
D002352:Carrier Proteins; C048842:NP protein, Influenza A virus; D019590:Nucleocapsid Proteins; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins; D012324:RNA-Dependent RNA Polymerase; D000074183:ATPases Associated with Diverse Cellular Activities; D004265:DNA Helicases; C122079:RUVBL2 protein, human