"AcCoA"lade for energy and life span.
Faced with changing food availability, organisms adapt metabolism to survive. In a recent issue of Cell, Lin et al. (2009) described the acetylation of an extranuclear enzyme being regulated by acetyl-CoA. This finding connects nutrient availability, energy status, and survival.
de Cabo
Rafael
R
Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA. decabora@mail.nih.gov
Navas
Plácido
P
D000105:Acetyl Coenzyme A / Q000378:metabolism*; D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008136:Longevity; D019764:Phosphoenolpyruvate Carboxykinase (ATP) / Q000378:metabolism
D000105:Acetyl Coenzyme A; D000123:Acetyltransferases; D019764:Phosphoenolpyruvate Carboxykinase (ATP); D005947:Glucose