Tarennanosides A-H, eight new lignan glucosides from Tarenna attenuata and their protective effect on H2O2-induced impairment in PC12 cells.
Eight new lignan glucosides, tarennanosides A-H (1-8, resp.), were isolated from the whole plant of Tarenna attenuata, together with three known compounds, fernandoside, (-)-lyoniresinol, and (-)-isolariciresinol. The planar structures of new compounds were elucidated mainly by analysis of physical and spectroscopic data, and the absolute configurations were determined by acid hydrolysis as well as CD spectroscopy. Compounds 1 and 2 exhibited potent antioxidant activities against H2O2-induced impairment in PC12 cells. Preliminary mechanism study by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method showed that these two compounds could act as radical scavengers.
Yang
Xian-Wen
XW
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China.
He
Hong-Ping
HP
Du
Zhi-Zhi
ZZ
Liu
Hai-Yang
HY
Di
Ying-Tong
YT
Ma
Yan-Lin
YL
Wang
Fang
F
Lin
Hua
H
Zuo
Yi-Qing
YQ
Li
Ling
L
Hao
Xiao-Jiang
XJ
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000737:chemistry*; D009005:Monosaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016716:PC12 Cells; D010851:Picrates / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*
D000975:Antioxidants; D001713:Biphenyl Compounds; D005960:Glucosides; D009005:Monosaccharides; D009281:Naphthalenes; D010851:Picrates; C541291:lyoniresinol 2a-O-(6-O-(4-hydroxy-3,5-dimethoxy)benzoyl)-beta-D-glucopyranoside; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl