Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.
Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC(50) value of 0.39 microM in a concentration-dependent manner without showing cytotoxic effects.
Igarashi
Yasuhiro
Y
Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp
Mogi
Tsukasa
T
Yanase
Saeko
S
Miyanaga
Satoshi
S
Fujita
Tsuyoshi
T
Sakurai
Hiroaki
H
Saiki
Ikuo
I
Ohsaki
Ayumi
A
D039903:Actinobacteria / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019306:Artemisia / Q000382:microbiology; D003110:Colonic Neoplasms; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014199:Trehalose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; C550819:brartemicin; D014199:Trehalose