Transient elastography for the prediction of oxaliplatin-associated liver injury in colon cancer patients: a preliminary analysis.
OBJECTIVE
The prognosis of advanced colon cancer has improved significantly over the last decade since new chemotherapy regimens including oxaliplatin have been developed. However, oxaliplatin-induced liver injury and characterized hepatic hemostatic status can occur after chemotherapy. The assessment of this type of liver injury is often difficult.


METHODS
Elastography (Fibroscan) was used to evaluate liver injury in five cases before and after 5-FU, leucovorin, and oxaliplatin combination (FOLFOX) treatment.


RESULTS
A clear change was observed in the stiffness of liver after chemotherapy within 48 h, and the hepatic stiffness was normalized in most cases after 2 weeks. Among the five patients, one patient showed aberrant elevation after a FOLFOX treatment, and the patient showed liver injury pathologically.


CONCLUSIONS
Elastography is a good tool for evaluating hepatic injury after FOLFOX treatment.
Oki
Eiji
E
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. okieiji@surg2.med.kyushu-u.ac.jp
Kakeji
Yoshihiro
Y
Taketomi
Akinobu
A
Yamashita
Yoichi
Y
Ohgaki
Kippei
K
Harada
Noboru
N
Iguchi
Tomohiro
T
Shibahara
Kotaro
K
Sadanaga
Noriaki
N
Morita
Masaru
M
Maehara
Yoshihiko
Y
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D010865:Pilot Projects
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin