Anti-MRSA activity of aldehyde Schiff base N-aryl thiosemicarbazones.
Eight different newly synthesised aldehyde Schiff base N-aryl thiosemicarbazones, differing in R, R' groups, are tested on 25 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and a standard strain. Antibacterial activity was carried out by a well-diffusion method in concentrations of 15-500 microg/well. Compounds 1, 2, 3, 4 and 6 showed good inhibition of MRSA. Increasing concentration of the test compounds enlarged the inhibition zone. Determination of minimum inhibitory concentration (MIC) was carried out using a dilution susceptibility test in concentrations of 4-512 microg/mL of the medium. The lowest MIC value (16 microg/mL) was produced by compound 4.
PSG Institute of Medical Science & Research and PSG Hospitals, Coimbatore, Tamil Nadu, India. glory_kriush@yahoo.com
S
S
Kriushnapriya
N S
NS
Malathy
A
A
Shamitha Begum
A C
AC
Baskaran
B
B
Appalaraju
K
K
Mani
K A
KA
Kandhaswamy
D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use; D000447:Aldehydes; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology / Q000627:therapeutic use; D012545:Schiff Bases / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use
D000081:Acetamides; D000447:Aldehydes; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D012545:Schiff Bases; D013882:Thiosemicarbazones; D014640:Vancomycin; D000069349:Linezolid