Leukoaraiosis severity and list-learning in dementia.
In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores <4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while severe LA was predicted to be associated with a dysexecutive profile. List-learning performances were standardized to a group of healthy older adults (n = 24). Analyses were conducted on a set of four factors derived from the list-learning paradigm, as well as error scores. Data indicate that LA severity is an important marker for understanding list learning in dementia.
Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, Florida, 32610, USA. cep23@phhp.ufl.edu
Catherine C
CC
Price
Kelly Davis
KD
Garrett
Angela L
AL
Jefferson
Stephanie
S
Cosentino
Jared J
JJ
Tanner
Dana L
DL
Penney
Rodney
R
Swenson
Tania
T
Giovannetti
Brianne Magouirk
BM
Bettcher
David J
DJ
Libon
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003704:Dementia / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007807:Language Tests; D049292:Leukoaraiosis / Q000145:classification / Q000150:complications* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology; D012691:Serial Learning / Q000502:physiology*; D012720:Severity of Illness Index