A case of persistent Müllerian duct syndrome with sertoli cell tumor and hydrometra in a dog.
A 10-year-old Miniature Schnauzer with bilateral cryptorchidism and male external genitalia was referred with a history of abdominal enlargement. Upon exploratory laparotomy, two tumors and a connecting structure similar to fluid-filled uterus were recognized. After cytological and bacterial examinations of the fluid and histological examination, this dog was diagnosed with bilateral Sertoli cell tumor with hydrometra. The karyotype of this dog was 78, XY and the sry gene was detected positive by PCR. We diagnosed this dog as a case of persistent Müllerian duct syndrome (PMDS), which is male pseudohermaphroditism. This is the first report regarding the incidence of PMDS in Miniature Schnauzers in Japan, and it suggests the involvement of a gene carrier.
Matsuu
Aya
A
Department of Veterinary Internal Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan. matsuu@muses.tottori-u.ac.jp
Hashizume
Takuya
T
Kanda
Teppei
T
Nagano
Masashi
M
Sugiyama
Akihiko
A
Okamoto
Yoshiharu
Y
Hikasa
Yoshiaki
Y
D000818:Animals; D012734:Disorders of Sex Development / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D005835:Genitalia / Q000473:pathology*; D008297:Male; D009095:Mullerian Ducts / Q000002:abnormalities*; D012707:Sertoli Cell Tumor / Q000473:pathology / Q000662:veterinary*; D014591:Uterine Diseases / Q000473:pathology / Q000662:veterinary*