Pharmacogenomics in dermatology: from susceptibility  genes to personalized therapy.
A significant proportion of patients with skin disease do not respond to treatment and adverse drug reactions are a common problem. Genetic factors are important determinants for both drug efficacy and toxicity. The fields of pharmacogenetics and pharmacogenomics examine inter-individual variations in the DNA sequence that are related to drug efficacy and toxicity. Here, we present pharmacogenomic data relevant to dermatology and explore the role of dermatologists in identifying patients who may respond to treatment or experience adverse drug reactions.
Pincelli
Carlo
C
Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy. carlo.pincelli@unimore.it
Pignatti
Marco
M
Borroni
Riccardo G
RG
D003880:Dermatology / Q000639:trends*; D064420:Drug-Related Side Effects and Adverse Reactions; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D010597:Pharmacogenetics / Q000639:trends*; D012871:Skin Diseases / Q000188:drug therapy* / Q000235:genetics; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics; D016896:Treatment Outcome