IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.
IL-1 causes a marked increase in the degree of expansion of naïve and memory CD4 T cells in response to challenge with their cognate antigen. The response occurs when only specific CD4 T cells can respond to IL-1beta, is not induced by a series of other cytokines and does not depend on IL-6 or CD-28. When WT cells are primed in IL-1R1(-/-) recipients, IL-1 increases the proportion of cytokine-producing transgenic CD4 T cells, especially IL-17- and IL-4-producing cells, strikingly increases serum IgE levels and serum IgG1 levels. IL-1beta enhances antigen-mediated expansion of in vitro primed Th1, Th2, and Th17 cells transferred to IL-1R1(-/-) recipients. The IL-1 receptor antagonist diminished responses to antigen plus lipopolysaccharide (LPS) by approximately 55%. These results indicate that IL-1beta signaling in T cells markedly induces robust and durable primary and secondary CD4 responses.
Ben-Sasson
Shlomo Z
SZ
Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA..
Hu-Li
Jane
J
Quiel
Juan
J
Cauchetaux
Stephane
S
Ratner
Maya
M
Shapira
Ilana
I
Dinarello
Charles A
CA
Paul
William E
WE
D000818:Animals; D000941:Antigens / Q000276:immunology*; D018106:CD28 Antigens / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D049109:Cell Proliferation; D005260:Female; D007136:Immunoglobulins / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology; D007375:Interleukin-1 / Q000276:immunology*; D020381:Interleukin-17 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D053573:Receptors, Interleukin-1 Type I / Q000172:deficiency / Q000235:genetics / Q000276:immunology / Q000378:metabolism
D000941:Antigens; D018106:CD28 Antigens; D007136:Immunoglobulins; D007375:Interleukin-1; D020381:Interleukin-17; D015850:Interleukin-6; D053573:Receptors, Interleukin-1 Type I