Study of the influence of radionuclide biokinetics on the efficiency of in vivo counting using Monte Carlo simulation.
To improve calibration methods of in vivo counting, our laboratory has developed a computer tool to model internal contamination and assess in vivo activity and corresponding organ absorbed doses. The aim of the recent work was to define a more realistic source based on biokinetic models. The influence of the biokinetic parameters on the in vivo counting was studied through the simulation of an acute inhalation intake of (241)Am. The tissue distribution of activity predicted by the biokinetic model was visualized. Two equivalent methods for determination of the efficiency related to the total activity distributed in the body were used. The comparison between the efficiency taking the biokinetics into account and the classically estimated efficiency quantifies the influence of the activity distribution in the body and provides conversion factors for correcting the classical efficiency to account for biokinetics.
Lamart
Stephanie
S
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire d'Evaluation de la Dose Interne, IRSN/DRPH/SDI/ LEDI BP 17, Fontenay-aux-Roses Cedex, France. stephanie.lamart@irsn.fr
Blanchardon
Eric
E
Molokanov
Andrey
A
Kramer
Gary H
GH
Broggio
David
D
Franck
Didier
D
D000465:Algorithms; D001681:Biological Assay / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D009010:Monte Carlo Method; D009928:Organ Specificity; D011829:Radiation Dosage; D011868:Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012062:Relative Biological Effectiveness; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000379:methods*
D011868:Radioisotopes