A case of multisystem Langerhans cell histiocytosis with primary hypothyroidism followed by type 1 diabetes mellitus.
We report a case of a 13-year-old female with Langerhans cell histiocytosis (LCH) and primary hypothyroidism followed by type 1 diabetes mellitus (DM), both of which are rare complications. In LCH diagnosis, imaging studies showed an enlargement of the thyroid gland, suggesting the involvement of LCH cells. While the pancreas appeared normal, insulin secretion markedly deteriorated 11 months after cessation of chemotherapy. Even without direct pancreatic involvement, there is a possibility that LCH could induce DM as a part of its long-term complications. In particular, thyroid involvement may be related to the onset of DM.
Department of Pediatrics, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Haruko
H
Shima
Mikako
M
Inokuchi
Hiroyuki
H
Shimada
D000293:Adolescent; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use
D007166:Immunosuppressive Agents