Impact of donor age on renal allograft function and survival.
BACKGROUND
The lack of cadaveric donors coupled with a rapidly growing number of potential recipients have stimulated the implementation of several strategies, including the acceptance of older donors, to increase the organ pool and reduce the waiting list for kidney transplantation. However several studies have demonstrated higher incidences of delayed graft function and poor graft outcomes among kidneys harvested from older donors.


OBJECTIVE
The objective of this study was to evaluate the influence of donor age on the function and long-term survival of renal allografts.


METHODS
We performed a retrospective review of the clinical data from 441 adult kidney transplantation from cadaveric heart-beating donors performed in our unit from May 1989 to May 2007.


RESULTS
Recipients of kidney allografts from older donors were significantly older (49.2 vs 43.7 years; P < .0001) and had a higher incidence of delayed graft function (15.1% vs 5.4%; P = .005). Renal function was superior following kidney transplantation using younger donors not only at 3 months (P < .0001) and 12 months (P < .0001) posttransplantation, but also upon long-term follow-up at 60 months (P < .0001) and 96 months (P = .030). Allograft survival censored for death with a functioning graft and patient survival were not different when comparing older versus younger donors. Multivariate analysis confirmed the lack of correlation between donor age and allograft failure.


CONCLUSIONS
Donor age showed no influence on allograft survival. However, kidney allografts from older donors displayed lower first year and long-term renal function.
Resende
L
L
Department of Nephrology, Hospital Central do Funchal, Funchal, Portugal. lmmresende@hotmail.com
Guerra
J
J
Santana
A
A
Mil-Homens
C
C
Abreu
F
F
da Costa
A G
AG
D000328:Adult; D000367:Age Factors; D002102:Cadaver; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology* / Q000706:statistics & numerical data; D008297:Male; D015999:Multivariate Analysis; D018579:Patient Selection; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data*; D055815:Young Adult