Cutaneous normolipemic plane xanthoma with supraglottic involvement in a patient with hand-Schüller-Christian Disease: a case report.
Normolipemic plane xanthoma (NPX) is a histiocytic disorder characterized by yellow-orange plaques in the periorbital areas, neck, upper trunk, and flexural folds. Association with systemic disease or paraproteinemia has been reported previously, but rarely with Langerhans cell histiocytosis (LCH). We report a case of Hand-Schüller-Christian disease (a type of LCH) in a patient who developed NPX with supraglottic involvement. NPX developed after several courses of chemotherapy and the supraglottic xanthoma occurred about 2 years later. The coexistence of LCH and non-LCH histiocytic lesions in this patient could be a result of chemotherapy-induced changes or may be just coincidental.
Lu
Yueh-Tsung
YT
Department of Dermatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Linkou, Taiwan.
Chen
Ting-Jui
TJ
Chung
Wen-Hung
WH
Kuo
Tseng-Tong
TT
Hong
Hong-Shang
HS
D019557:Dermatitis, Perioral / Q000209:etiology* / Q000473:pathology; D004825:Epiglottis / Q000473:pathology / Q000601:surgery; D004826:Epiglottitis / Q000209:etiology* / Q000473:pathology; D005141:Eyelid Diseases / Q000209:etiology* / Q000473:pathology; D005487:Foam Cells / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008297:Male; D012867:Skin / Q000473:pathology; D014973:Xanthomatosis / Q000150:complications* / Q000473:pathology; D055815:Young Adult