Regulation of oxygen homeostasis by hypoxia-inducible factor 1.
Metazoan organisms are dependent on a continuous supply of O(2) for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. HIF-1 activity is induced in response to continuous hypoxia, intermittent hypoxia, growth factor stimulation, and Ca(2+) signaling. HIF-1 mediates adaptive responses to hypoxia, including erythropoiesis, angiogenesis, and metabolic reprogramming. In each case, HIF-1 regulates the expression of multiple genes encoding key components of the response pathway. HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively.
Vascular Program, Institute for Cell Engineering, McKusick-Nathans Institute of Genetic Medicine, Baltimore, Maryland, USA. gsemenza@jhmi.edu
Gregg L
GL
Semenza
D000818:Animals; D015497:HIV-1 / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000473:pathology; D010101:Oxygen Consumption / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology