[Islet transplantation as a clinical tool: present state and future perspectives].
Islet transplant is an innovative treatment for type 1 diabetic patients, which still lies between experimental and approved transplant therapy. Islet cells are seeded in a non-physiological territory where an uncertain fraction will be able to adapt and survive. Thus, the challenge lies in improving the whole procedure, employing the tools of cell biology, immunology and laboratory techniques, in order to reach the results obtained with whole organ transplant. This review describes the procedure, its progress to the present methodology and clinical results obtained. Future perspectives of islet transplantation in the light of recent biotechnological advances are also focused.
Eliaschewitz
Freddy Goldberg
FG
Núcleo de Terapia Celular e Molecular, Universidade de São Paulo.
Franco
Denise Reis
DR
Mares-Guia
Thiago Rennó
TR
Noronha
Irene L
IL
Labriola
Leticia
L
Sogayar
Mari Cleide
MC
D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000009:adverse effects / Q000379:methods / Q000639:trends