64-Channel cardiac computed tomography: intraobserver and interobserver variability, part 2: global and regional ventricular function, mass, and first pass perfusion.
OBJECTIVE
To assess intraobserver and interobserver variability in cardiac computed tomographic measurements of global biventricular function, left ventricular (LV) regional wall motion, systolic wall thickening, and first pass perfusion in 3 patient cohorts at very low, low to intermediate, and intermediate to high cardiac risk.


METHODS
One hundred thirty-three patients underwent 64-channel cardiac computed tomography. Images were analyzed by 2 experienced, blinded observers. Intraobserver and interobserver agreements were calculated for each cohort and were combined for patients with structurally normal hearts.


RESULTS
Intraobserver and interobserver agreements were good for all global and regional LV parameters with narrow levels of agreement. Right ventricular ejection fraction agreement was also good, but other right ventricular parameters showed wide levels of agreement.


CONCLUSIONS
Biventricular ejection fraction, LV regional wall motion, and systolic wall thickening, volume, and mass show good reproducibility for use in standard clinical practice. Right ventricular volumetric and mass data in patients with congenital heart disease should be interpreted with caution.
Nicol
Edward D
ED
Department of Cardiology, Royal Brompton Hospital and Harefield NHS Trust, London, United Kingdom. cyprusdoc@doctors.org.uk
Stirrup
James
J
Roughton
Michael
M
Padley
Simon P G
SP
Rubens
Michael B
MB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015897:Comorbidity; D003287:Contrast Media; D017023:Coronary Angiography / Q000706:statistics & numerical data*; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging*; D007091:Image Processing, Computer-Assisted; D007472:Iohexol / Q000031:analogs & derivatives; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D013318:Stroke Volume; D013599:Systole; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000453:epidemiology; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000453:epidemiology; D016276:Ventricular Function; D015646:Ventriculography, First-Pass
D003287:Contrast Media; D007472:Iohexol; C038192:iopromide