Taenia crassiceps: fatty acids oxidation and alternative energy source in in vitro cysticerci exposed to anthelminthic drugs.
Cysticerci metabolic studies demonstrate alternative pathways responsible for its survival, such as energy sources, fatty acids oxidation and excretion of beta-hydroxybutyrate, which indicates the capability of energy production from proteins. The aim of this study was to detect alternative metabolic pathways for energy production and its end products in Taenia crassiceps cysticerci in vitro exposed to praziquantel and albendazole, in sub-lethal doses. Spectrophotometer and chromatographic analysis were performed to detect: propionate, acetate, beta-hydroxybutyrate, total proteins, urea and creatinine, SE by cysticerci in vitro exposed to praziquantel and albendazole. The drugs influenced the metabolism by inducing the creatinine phosphate phosphorylation as an alternative energy source, inhibiting the use of proteins and amino acids in the acid nucleic synthesis; and preventing the budding and replication of the cysticerci. This study also highlights the description of urea excretion, which is an important metabolic pathway to excrete toxic products such as ammonia, and the fatty acid oxidation as an alternative energy source in cysticerci exposed to anthelmintic drugs.
Tropical Pathology and Public Health, Institute from Federal, University of Goias, Goiania, Goias, Brazil. mvinaud@yahoo.com.br
Marina Clare
MC
Vinaud
Cirlane Silva
CS
Ferreira
Ruy de Souza
Rde S
Lino Junior
José Clecildo Barreto
JC
Bezerra
D020155:3-Hydroxybutyric Acid / Q000378:metabolism; D000085:Acetates / Q000378:metabolism; D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D003404:Creatinine / Q000378:metabolism; D003552:Cysticercus / Q000187:drug effects* / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism*; D015801:Helminth Proteins / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010084:Oxidation-Reduction; D011223:Praziquantel / Q000494:pharmacology*; D011422:Propionates / Q000378:metabolism; D014508:Urea / Q000378:metabolism
D000085:Acetates; D000871:Anthelmintics; D005227:Fatty Acids; D015801:Helminth Proteins; D011422:Propionates; D011223:Praziquantel; D014508:Urea; D003404:Creatinine; D015766:Albendazole; D020155:3-Hydroxybutyric Acid