The response of giant phospholipid vesicles to millimeter waves radiation.
Due to the increasing interest in millimeter waves (MMW) applications in medicine and telecommunications, the investigation of their potential biological effects is of utmost importance. Here we report results of the study of interaction between low-intensity radiation at 53.37 GHz and giant vesicles. Direct optical observations of vesicles subjected to irradiation enabled the monitoring in real time of the response of vesicles. Physical changes of vesicles, i.e. elongation, induced diffusion of fluorescent dye di-8-ANEPPS, and increased attractions between vesicles are demonstrated. These effects are reversible and occur only during irradiation with a "switch on" of the effect requiring a short time. Since the average temperature change was very small the effects could not be attributed to thermal mechanisms. We assume that the interaction of MMW with lipid membrane leads to changes at the membrane-water interface, where charged and dipolar residues are located.
Ramundo-Orlando
Alfonsina
A
Institute of Neurobiology and Molecular Medicine, Consiglio Nazionale delle Ricerche (CNR), Via del Fosso del Cavaliere, 00133 Rome, Italy. alfonsina.ramundoorlando@artov.inmm.cnr.it
Longo
Giovanni
G
Cappelli
Mauro
M
Girasole
Marco
M
Tarricone
Luciano
L
Beneduci
Amerigo
A
Massa
Rita
R
D008872:Microwaves; D010743:Phospholipids / Q000737:chemistry / Q000528:radiation effects*; D053835:Unilamellar Liposomes / Q000737:chemistry / Q000528:radiation effects*
D010743:Phospholipids; D053835:Unilamellar Liposomes