Prevalence of HLA-B*5701 in HIV-infected patients in Spain (results of the EPI Study).
BACKGROUND
A hypersensitivity reaction (HSR) is associated with abacavir (ABC), a nucleoside reverse transcriptase inhibitor. Genetic association of ABC HSR with the presence of HLA-B*5701 has been demonstrated in PREDICT-1 study, showing a prevalence of 5.6% in HIV-infected population. However the prevalence of this allele in HIV-infected patients in Spain has not been established yet.


METHODS
This is a cross-sectional epidemiological study that included 1,198 patients in 74 centers that serve the HIV-infected population of Spain. HLA-B*5701 was checked both in the hospital lab and one central lab, showing an overall prevalence of this allele of 6%.


RESULTS
HLA-B*5701 was most prevalent in Caucasian population (6.5%). Concordance between the local and central lab was very high for positive and negative results (95.7% and 99.3%, respectively).


CONCLUSIONS
These aspects define this test as a useful tool for the management of HIV-infected patients.
Arrizabalaga
J
J
Infectious Diseases Unit, H Donostia, San Sebastian, Spain.
Rodriguez-Alcántara
F
F
Castañer
J L
JL
Ocampo
A
A
Podzamczer
D
D
Pulido
F
F
Riera
M
M
Sanz
J
J
Pascual-Bernaldez
M
M
Dal-Re
R
R
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D015224:Dideoxynucleosides / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005820:Genetic Testing; D015658:HIV Infections / Q000188:drug therapy*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D013030:Spain / Q000453:epidemiology; D000099227:Abacavir
D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D018894:Reverse Transcriptase Inhibitors; D000099227:Abacavir; C484830:HLA-B*57:01 antigen