Risk factors for recurrent catheter-related infections after catheter-related bloodstream infections.
OBJECTIVE
This study was performed to identify the risk factors for recurrent catheter-related infections (CRIs) following non-tunneled central venous catheter (CVC) reinsertion after catheter-related bloodstream infections (CRBSIs).


METHODS
A retrospective cohort was constructed from a computer database for patients who underwent reinsertion of a non-tunneled CVC after a CRBSI during the period January 2004 to December 2007. Among these patients, recurrent CRI cases were selected through an electronic chart review, and the risk factors for recurrent CRI were investigated.


RESULTS
Fifty-three patients who had had a reinserted non-tunneled CVC after a CRBSI were analyzed and 22 patients were considered as having recurrent CRIs (41.5%). Recurrent/persistent CRBSI after catheter reinsertion was observed in 16 patients, and six patients with systemic inflammatory response syndrome revealed positive results of an identical organism with the initial CRBSI in semi-quantitative reinsertion-catheter tip cultures. In multivariate analysis, fungal CRBSI compared with bacterial infection (adjusted hazard ratio (HR) 7.77, 95% confidence interval (CI) 1.71-35.36) and CRBSI occurrence during intensive care unit (ICU) care (adjusted HR 5.20, 95% CI 1.41-19.18) were revealed as independent risk factors for recurrent CRIs after catheter reinsertion on account of CRBSIs.


CONCLUSIONS
A substantial proportion of the patients with CRBSIs revealed recurrent CRIs after catheter reinsertion. Fungal CRBSIs when compared with bacterial infections and CRBSI occurrence during ICU care were independent risk factors for recurrent CRIs following catheter reinsertion after a CRBSI.
Chin
Bum Sik
BS
Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seoul, Korea 120-752.
Han
Sang Hoon
SH
Lee
Han Sung
HS
Jeong
Su Jin
SJ
Choi
Heekyoung
H
Kim
Chang Oh
CO
Choi
Jun Yong
JY
Song
Young Goo
YG
Kim
June Myung
JM
D000368:Aged; D016470:Bacteremia / Q000453:epidemiology* / Q000209:etiology; D055499:Catheter-Related Infections / Q000453:epidemiology* / Q000209:etiology; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D016469:Fungemia / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D012008:Recurrence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000628:therapy