Placental abnormalities and preeclampsia in trisomy 13 pregnancies.
Women who are carrying a trisomy 13 fetus are prone to have an abnormal placenta as well as to develop preeclampsia in the second and third trimesters. This article provides a comprehensive review of placental abnormalities, such as small placental volume, reduced placental vascularization, a partial molar appearance of the placenta and placental mesenchymal dysplasia, and preeclampsia associated with trisomy 13 pregnancies. The candidate preeclampsia-causing genes on chromosome 13, such as sFlt1, COL4A2 and periostin, are discussed.
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan. cpc_mmh@yahoo.com
Chih-Ping
CP
Chen
D015815:Cell Adhesion Molecules / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D024141:Collagen Type IV / Q000235:genetics; D005260:Female; D006801:Humans; D010922:Placenta Diseases; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D014314:Trisomy; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000235:genetics
D015815:Cell Adhesion Molecules; D024141:Collagen Type IV; C512835:POSTN protein, human; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1