High-molecular weight adiponectin is associated with coronary artery angiographic findings in Asian Indians.
Asian Indians (AIs) have a higher prevalence and a more aggressive form of coronary artery disease (CAD), and it has been suggested that hypoadiponectinemia may have a role in this accelerated CAD. The present study was undertaken to determine the extent and severity of angiographic findings in 2 groups of CAD patients matched for age and sex, AIs (n = 29) vs whites (n = 30), and to elucidate the potential relationship between adiponectin (total and high-molecular weight [HMW] form) and the severity and extent of coronary angiographic findings in both groups. Angiographic findings were assessed using the modified Gensini index; and 2 scores, scores 1 and 2, were used to assess the severity and extent. Both Gensini index scores 1 and 2 were higher in the AI group compared with the white group (144.4 +/- 87.1 vs 93.5 +/- 56.3 and 127.2 +/- 86.5 vs 80.1 +/- 39.3, respectively; P < .05). Adiponectin levels were similar in both groups. Total adiponectin and HMW adiponectin were positively associated with Gensini index score 1 (r = 0.62, P = .004 and r = 0.64, P = .003) and score 2 (r = 0.51, P = .021 and r = 0.54, P = .013), respectively, in AI men, whereas there was no significant association in white men. Thus, AIs had more severe CAD compared with whites; and in AI men with CAD, total adiponectin and HMW adiponectin were associated with the severity of angiographic scores.
Zornitzki
Taiba
T
Metabolic Unit and Department of Medicine, Kaplan Medical Center, Rehovot and the Hebrew University Hadassah Medical School, Rehovot, Israel.
Reshef
Naama
N
Ayzenberg
Oded
O
Cohen
Rinat
R
Gandelman
Gera
G
Frystyk
J Jan
JJ
Flyvbjerg
Allan
A
Knobler
Hilla
H
D052242:Adiponectin / Q000378:metabolism; D000368:Aged; D016022:Case-Control Studies; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007194:India / Q000208:ethnology; D007557:Israel; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018709:Statistics, Nonparametric
C499918:ADIPOQ protein, human; D052242:Adiponectin