Lessons learned from the study of JunB: new insights for normal and leukemia stem cell biology.
JunB is important in maintaining normal hematopoietic stem cell functions, but the mechanisms underlying its activity are not well understood. In the current issue of Cancer Cell, a study by Santaguida et al. provides new insights into JunB's function and the genesis of myeloid disease.
James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA.
Monica L
ML
Guzman
Craig T
CT
Jordan
D000818:Animals; D002454:Cell Differentiation; D007938:Leukemia / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology*; D016755:Proto-Oncogene Proteins c-jun / Q000502:physiology*
D016755:Proto-Oncogene Proteins c-jun