Occurrence of sesquiterpene derivatives in Scleria striatonux de wild (Cyperaceae).
Scleria striatonux (Cyperaceae), a spice traditionally used in Cameroon, displayed an antiplasmodial activity. Two new sesquiterpenes, 1 (sclerienone A) and 2 (sclerienone B), have subsequently been isolated from the methylene chloride/methanol extract of the rhizome. Their separation involved a combination of methods including repeated silica gel open column chromatography, Sephadex LH-20 and semi-preparative HPLC. Structure elucidation was achieved by means of chemical tests and extensive spectral studies.
Laboratoire de Pharmacognosie et Phytochimie, Ecole de Pharmacie Genève, Université de Genève, Quai Ansermet 30, 1211 Genève 4, Switzerland.
Kennedy
K
Nyongbela
Karine Ioset
KI
Ndjoko
Reto
R
Brun
Sergio
S
Wittlin
James
J
Mbah
Felix
F
Makolo
Marc
M
Akam
Claire
C
Wirmum
Simon
S
Efange
Kurt
K
Hostettmann
D000818:Animals; D029785:Cyperaceae / Q000737:chemistry*; D015394:Molecular Structure; D010961:Plasmodium / Q000187:drug effects; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology
D012717:Sesquiterpenes; C541201:sclerienone A; C541202:sclerienone B