A new beta-chain variant: Hb stockholm [beta 7(A4)GluAsp] causes falsely low Hb A(1c).
A new beta-hemoglobin (Hb) variant, Hb Stockholm [beta7(A4)GluAsp], is described. The variant was characterized by mass spectrometry and DNA sequencing. The new variant is clinically silent but interferes with Hb A(1c) quantification using ion exchange chromatography, causing a falsely low Hb A(1c) level when using the Bio-Rad VARIANT II System.
Bergman
Ann-Charlotte
AC
Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden. ann-charlotte.r.bergman@karolinska.se
Beshara
Soheir
S
Byman
Irene
I
Karim
Raja
R
Landin
Britta
B
D006441:Hemoglobin A / Q000032:analysis*; D006455:Hemoglobins, Abnormal / Q000032:analysis / Q000235:genetics*; D006801:Humans; D009154:Mutation; D021241:Spectrometry, Mass, Electrospray Ionization; D055544:beta-Globins / Q000032:analysis* / Q000235:genetics*
D006455:Hemoglobins, Abnormal; D055544:beta-Globins; D006441:Hemoglobin A