Treatment with an anti-inflammatory drug is detrimental for muscle regeneration at Bothrops jararacussu envenoming: an experimental study.
We evaluated the effects of deflazacort (DFZ) on muscle regeneration following Bothrops jararacussu envenoming. Tibialis anterior muscle from adult mice was injected with 80 microg of venom. Animals received DFZ during 6days. Seven and 60 days after envenoming, DFZ lead to a decrease in the total number of muscle fibers and an increase in interstitial fibrosis. We conclude that DFZ treatment may aggravate the loss of muscle mass after B. jararacussu envenoming.
Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
Viviane Urbini
VU
Vomero
Maria Julia
MJ
Marques
Humberto Santo
HS
Neto
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017837:Bothrops; D003435:Crotalid Venoms / Q000633:toxicity*; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D011282:Pregnenediones / Q000009:adverse effects* / Q000627:therapeutic use; D012038:Regeneration / Q000187:drug effects*; D012909:Snake Bites / Q000188:drug therapy* / Q000503:physiopathology
D000893:Anti-Inflammatory Agents; D003435:Crotalid Venoms; D011282:Pregnenediones; C021988:deflazacort