Different embryonic development after blastomere biopsy for preimplantation genetic diagnosis, observed by time-lapse imaging.
Using time-lapse imaging, we found different behavior of mouse embryonal development after blastomere biopsy for preimplantation genetic diagnosis. Blastomere removal has effects on the developmental behavior of the mouse embryo, including speed of growth, contraction and expansion movements, and hatching.
Terada
Yukihiro
Y
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan. Electronic address: terada@mail.tains.tohoku.ac.jp.
Ugajin
Tomohisa
T
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
Hasegawa
Hisataka
H
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
Nabeshima
Hiroshi
H
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
Yaegashi
Nobuo
N
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
D000818:Animals; D001706:Biopsy; D001757:Blastomeres / Q000473:pathology*; D002970:Cleavage Stage, Ovum / Q000473:pathology / Q000502:physiology; D003952:Diagnostic Imaging / Q000379:methods*; D004622:Embryo, Mammalian / Q000166:cytology / Q000473:pathology; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D006801:Humans; D051379:Mice; D018715:Microscopy, Video / Q000379:methods; D019836:Preimplantation Diagnosis / Q000379:methods*; D014741:Video Recording / Q000379:methods