Treatment of skin cancer and pre-cancer using topical ALA-PDT--a single hospital experience.
Our hospital (Shanghai Skin Diseases & STD Hospital) started to study 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) in 1996. So far, we have treated 76 cases of skin cancer and pre-cancer using topical ALA-PDT. They included squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Bowen's disease (BD), mammary and extramammary Paget disease, actinic keratosis (AK) and erythroplasia of Queyrat. In this overview article, we would like to present several representative cases and discuss our experience.
Wang
Xiu-Li
XL
Shanghai Skin Diseases & STD Hospital, Shanghai 200050, PR China. xiuliwang2001@yahoo.com.cn
Wang
Hong-Wei
HW
Guo
Min-Xia
MX
Xu
Shi-Zheng
SZ
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D004919:Erythroplasia / Q000188:drug therapy; D005260:Female; D006760:Hospitalization; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000188:drug therapy*; D010778:Photochemotherapy; D011230:Precancerous Conditions / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy*
C058222:2-amino-5-hydroxy-4-oxopentanoic acid; D000622:Aminolevulinic Acid