[Functional correlates of the brain 5-HT2A and 5-HT2C serotonin receptors and expression of 5-HT2A AND 5-HT2C genes in aggressive and nonaggressive Norway rats].
Functional activity of the brain 5-HT2A and 5-HT2C serotonin receptors and expression of 5-HT2A and 5-HT2C genes in Norway rats selectively bred for 60 generations for high level and for a lack of fear-induced aggression towards humans were studied. There were no essential differences between aggressive and tame rats in 5-HT2A receptor mRNA level in the midbrain, hippocampus and frontal cortex as well as in the intensity of head-twitch induced by selective 5-HT2A agonist DOI. At the same time, administration of 5-HT2C receptor selective agonist MK-212 reduced the amplitude of acoustic startle response in tame but not in aggressive animals. The increase in 5-HT2C receptor mRNA level in the frontal cortex and hippocampus of nonaggressive rats compared to aggressive animals was shown. The data indicate involvement of the brain 5-HT2C receptor rather than 5-HT2C receptors in the mechanisms of genetically predetermined suppression of fear-induced aggressive behavior.
N K
NK
Popova
V S
VS
Naumenko
R V
RV
Kozhemiakina
I Z
IZ
Pliusnina
D000374:Aggression; D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005625:Frontal Lobe / Q000378:metabolism*; D005786:Gene Expression Regulation; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011719:Pyrazines / Q000494:pharmacology; D051381:Rats; D044402:Receptor, Serotonin, 5-HT2A / Q000096:biosynthesis*; D044405:Receptor, Serotonin, 5-HT2C / Q000096:biosynthesis*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D000662:Amphetamines; D009419:Nerve Tissue Proteins; D011719:Pyrazines; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D017366:Serotonin Receptor Agonists; C014896:6-chloro-2-(1-piperazinyl)pyrazine; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine