Schistosoma haematobium and Schistosomiasis mansoni: production of an estradiol-related compound detected by ELISA.
Estradiol is a steroid hormone secreted principally by the ovarian follicles in vertebrate animals. We have identified the production of an estradiol-related molecule in the trematodes Schistosoma haematobium and Schistosomiasis mansoni. We show in this work that this molecule related to estradiol is present in schistosome worm extracts. The detection method ELISA specific for estradiol, revealed the expression of this estradiol-related molecule in schistosome worm extracts, but not in Fasciola hepatica worm extracts. Our results demonstrate for the first time the production of an estradiol-related compound by a human parasite of the genus Schistosoma.
Botelho
M C
MC
CIBP-Centre for Immunology and Parasite Biology, National Institute of Health, Rua Alexandre Herculano 321, Porto, Portugal. monicabotelho@hotmail.com
Crespo
M
M
Almeida
A
A
Vieira
P
P
Delgado
M L
ML
Araujo
L
L
Machado
J C
JC
Correia da Costa
J M
JM
D000293:Adolescent; D000328:Adult; D000818:Animals; D000947:Antigens, Helminth / Q000032:analysis / Q000096:biosynthesis*; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D006224:Cricetinae; D004797:Enzyme-Linked Immunosorbent Assay; D004958:Estradiol / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D005210:Fasciola hepatica / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D012548:Schistosoma haematobium / Q000276:immunology / Q000378:metabolism*; D012550:Schistosoma mansoni / Q000276:immunology / Q000378:metabolism*; D012553:Schistosomiasis haematobia / Q000378:metabolism / Q000469:parasitology; D012555:Schistosomiasis mansoni / Q000378:metabolism / Q000469:parasitology; D013739:Testosterone / Q000097:blood; D055815:Young Adult
D000947:Antigens, Helminth; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone