IL-23R polymorphisms in patients with ankylosing spondylitis in Korea.
OBJECTIVE
IL23R polymorphisms have been shown to have a significant association with ankylosing spondylitis (AS). To date, these studies have been restricted to Caucasian patients with AS. Our study addresses this relationship in Korean patients with AS.


METHODS
A total of 451 patients with AS and 392 ethnically matched healthy controls were enrolled. All patients were native Koreans with AS satisfying the modified New York criteria. In total, 10 single nucleotide polymorphisms (SNP) within the IL-23R gene cluster were genotyped.


RESULTS
No IL-23R SNP were found to be associated with AS in Koreans.


CONCLUSIONS
The association of IL23R and AS that is seen in Caucasian patients with AS is not present in Korean patients with AS.
Sung
Il-Hoon
IH
Hanyang University College of Medicine, and the Hospital for Rheumatic Diseases, Seoul, Korea.
Kim
Tae-Hwan
TH
Bang
So-Young
SY
Kim
Tae-Jong
TJ
Lee
Bitnara
B
Peddle
Lynette
L
Rahman
Proton
P
Greenwood
Celia M T
CM
Hu
Pingzhao
P
Inman
Robert D
RD
D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000235:genetics*
C515500:IL23R protein, human; D018123:Receptors, Interleukin