Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese Zucker (fa/fa) rats.
Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H(2)O(2)-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.
Institute of Medicine, Section of Medical Biochemistry, University of Bergen, Haukeland University Hospital, Bergen, Norway. hege.wergedahl@med.uib.no
Hege
H
Wergedahl
Kjetil
K
Berge
Pavol
P
Bohov
Karl-Johan
KJ
Tronstad
Lise
L
Madsen
Rolf K
RK
Berge
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D050556:Fatty Acid-Binding Proteins / Q000187:drug effects / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009765:Obesity / Q000188:drug therapy* / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects*; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker; D013440:Sulfides / Q000008:administration & dosage / Q000494:pharmacology*
D000975:Antioxidants; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D007328:Insulin; D012333:RNA, Messenger; D013440:Sulfides; D008315:Malondialdehyde; C062078:1-(carboxymethylthio)tetradecane; D006861:Hydrogen Peroxide