1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity.
A number of 1-propargyl-1,8-naphthyridine-3-carboxamide derivatives (15-35) have been synthesized and screened for their in vitro cytotoxicity and anti-inflammatory activity. Compounds 22, 31 and 34 have shown high cytotoxicity against a number of cancer cell lines, while compound 24 showed significant anti-inflammatory activity.
Kumar
Vivek
V
Chemical Research, Dabur Research Foundation, Ghaziabad, UP, India. kumarv@dabur.com
Jaggi
Manu
M
Singh
Anu T
AT
Madaan
Alka
A
Sanna
Vinod
V
Singh
Pratibha
P
Sharma
Pramod K
PK
Irchhaiya
Raghuveer
R
Burman
Anand C
AC
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D016207:Cytokines / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D020128:Inhibitory Concentration 50; D051379:Mice; D009287:Naphthyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D016207:Cytokines; D009287:Naphthyridines