Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells.
Paradigm-shifting modalities to more efficiently deliver drugs to cancerous lesions require the following attributes: nanoscale-size, targetability, and stability under physiological conditions. Often, these nanoscale drug delivery vehicles are limited due to agglomeration, poor solubility, or cytotoxicity. Thus, we have designed a methodology to encapsulate hydrophobic antineoplastic chemotherapeutics within a 20-30 nm diameter, pH-responsive, nonagglomerating, nontoxic calcium phosphate nanoparticle matrix. In the present study, we report on calcium phosphate nanocomposite particles (CPNPs) that encapsulate both fluorophores and chemotherapeutics, are colloidally stable in physiological solution for an extended time at 37 degrees C and can efficaciously deliver hydrophobic antineoplastic agents, such as ceramide, in several cell model systems.
Kester
Mark
M
Penn State College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA.
Heakal
Yasser
Y
Fox
Todd
T
Sharma
Arati
A
Robertson
Gavin P
GP
Morgan
Thomas T
TT
Altinoğlu
Erhan I
EI
Tabaković
Amra
A
Parette
Mylisa R
MR
Rouse
Sarah M
SM
Ruiz-Velasco
Victor
V
Adair
James H
JH
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000737:chemistry*; D004337:Drug Carriers; D053761:Nanocomposites; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D002130:Calcium Phosphates; D004337:Drug Carriers; C020243:calcium phosphate