Vitamin A/retinoids signalling in the human lung.
Vitamin A is used as a generic term for all vitamin A derivatives with retinol-like biological activity. Retinol is the main parent compound for vitamin A. It derives from carotenoids (provitamin A) and also directly from the pre-formed vitamin A contained in the diet. The term "retinoid" is a generic descriptor of compounds structurally related to vitamin A and the synthetic analogues of retinol with or without biological activity. Retinoic acid is the active cellular catabolite. Vitamin A/retinoids have been given cancer-preventive functions and subsequently used in clinical trials to reduce lung cancer incidence in high-risk individuals. The results obtained have been in contradiction with both in vivo and in vitro promising studies. It seems therefore necessary to develop a better understanding of the vitamin A/retinoids signalling pathways in the lung. With this aim, we summarise the relevant knowledge focussed on the lung.
Centre de Ressources Biologiques, CHU de Nancy - Laboratoire de Pathologie Cellulaire et Moléculaire en Nutrition (LPCMN), INSERM U724, Faculté de Médecine, 54505, Vandoeuvre-Lès-Nancy, France. Stephane.Poulain@nancy.inserm.fr
Stéphane
S
Poulain
Fanny
F
Evenou
Marie-Christiane
MC
Carré
Serge
S
Corbel
Jean-Michel
JM
Vignaud
Nadine
N
Martinet
D000970:Antineoplastic Agents / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000201:enzymology / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D012176:Retinoids / Q000378:metabolism*; D014801:Vitamin A / Q000378:metabolism*
D000970:Antineoplastic Agents; D018168:Receptors, Retinoic Acid; D012176:Retinoids; D014801:Vitamin A