Measurement of liquid and solid component parameters in canine vocal fold lamina propria.
This study aimed to measure solid and liquid component parameters for canine vocal fold lamina propria tissue, as is consistent with the solid and liquid fraction parameters in the context of the biphasic theory. A liquid-displacement apparatus was developed and utilized to estimate volumes of small samples of tissue. Accuracy was determined by calibrations with an object of known mass and density (copper). The experimental apparatus was then used to determine the volume of eight tissue samples, followed by an apparently complete dehydration of the samples, yielding the dry or solid tissue. The mass and volume fractions of the liquid component were sufficiently higher than those of the solid component. These results represent preliminary experimental evidence for the biphasic composition (solid-liquid) of canine lamina propria tissue as predicted in the biphasic theory. This study presents an effective experimental method to estimate some of the biphasic model parameters, and may provide a valuable application in exploring the viscoelastic behaviors of vocal fold lamina propria tissue.
Phillips
Robert
R
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin-Medical School, Madison, Wisconsin 53792-7375, USA.
Zhang
Yu
Y
Keuler
Megan
M
Tao
Chao
C
Jiang
Jack J
JJ
D000818:Animals; D001834:Body Water / Q000502:physiology; D003890:Desiccation; D004285:Dogs; D009092:Mucous Membrane / Q000502:physiology*; D014827:Vocal Cords / Q000502:physiology*