Efalizumab for severe refractory atopic eczema: retrospective study on 11 cases.
BACKGROUND
Efalizumab is a recombinant humanized murine monoclonal antibody against CD11a, approved for the treatment of plaque psoriasis. However, recent reports suggest that it also may be effective in the treatment of severe atopic dermatitis (AD).


OBJECTIVE
To evaluate the clinical effect of efalizumab in AD.


METHODS
A systematic retrospective study of the medical files of patients treated with efalizumab for AD in Danish dermatology departments. Positive outcome was defined as improvement of the disease registered in the patient's file over a period exceeding 6 months.


RESULTS
Two of eleven patients had a positive outcome. Nine patients stopped treatment due to progression of AD or lack of effect.


CONCLUSIONS
Retrospective study.


CONCLUSIONS
Only a minority of patients with severe AD responded to efalizumab treatment in a standard dose.
Ibler
K
K
Department of Dermatology, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark. kristinaibler@hotmail.com
Dam
T N
TN
Gniadecki
R
R
Kragballe
K
K
Jemec
G B E
GB
Agner
T
T
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D003879:Dermatologic Agents; C472181:efalizumab