[Structural and functional views of the intracellular viral RNA sensor RIG-I].
The innate immunity plays a crucial role in initial response to viral infection. Retinoic acid inducible gene-I (RIG-I) detects diverse viral RNAs in host cell and triggers immune response, producing antiviral cytokine, namely type I interferon (IFN). Recently, we analyzed the substrate RNAs and identified RNA binding domain of RIG-I. Here we discuss structural mechanism of intracellular RNA sensing system by RIG-I and function of RIG-I family molecules in the antiviral innate immunity.
Go
Seigyoku
S
Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University. sgo@virus.kyoto-u.ac.jp
Yoneyama
Mitsutoshi
M
Fujita
Takashi
T
D000818:Animals; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000737:chemistry* / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology*; D007370:Interferon Type I / Q000096:biosynthesis; D005810:Multigene Family; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D012367:RNA, Viral / Q000276:immunology*; D011971:Receptors, Immunologic; D015398:Signal Transduction; D014777:Virus Diseases / Q000276:immunology
D007370:Interferon Type I; D012367:RNA, Viral; D011971:Receptors, Immunologic; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases