Jejunal pouch reconstruction but not preservation of duodenal passage after total gastrectomy reduces plasma cholecystokinin and pancreatic polypeptide long term in pigs.
OBJECTIVE
The long-term effects of reconstructions of the gastrointestinal tract after gastrectomy on plasma levels of gastrointestinal hormones that contribute to food intake controls were evaluated.


METHODS
Domestic pigs were randomly assigned to sham-surgery or total gastrectomy followed by reconstruction with oesophagojejunostomy on a Roux-en-Y loop (OJRY), jejunal interposition between the oesophagus and the duodenum (OJD), or an oesophagojejunostomy with a jejunal pouch reservoir (J-pouch) on a Roux-en-Y loop. Plasma levels of peptides were analysed by radioimmunoassay (RIA).


RESULTS
Ten weeks after surgery, levels of cholecystokinin (CCK) and pancreatic polypeptide (PP) were significantly lowered (79.6% and 67.0%, respectively) in animals with a J-pouch, but not in sham-operated animals or animals with OJRY or OJD, as compared to preoperative levels. The levels of neuropeptide Y (NPY) and peptide YY (PYY) remained unchanged, irrespective of the mode of reconstruction.


CONCLUSIONS
J-pouch, but not preservation of duodenal passage after total gastrectomy, lowers levels of CCK and PP, peptides that reduce food intake.
Department of Surgery, Lund University Hospital, Lund, Sweden. ulrika.smedh@med.lu.se
Ulrika
U
Smedh
Lars
L
Hansson
Rolf
R
Ekman
Thomas
T
Zilling
D000713:Anastomosis, Roux-en-Y; D000818:Animals; D001835:Body Weight; D002766:Cholecystokinin / Q000097:blood*; D039021:Colonic Pouches; D004195:Disease Models, Animal; D004386:Duodenum / Q000601:surgery; D004435:Eating; D004947:Esophagus / Q000601:surgery; D005260:Female; D007583:Jejunum / Q000601:surgery; D008297:Male; D009478:Neuropeptide Y / Q000097:blood; D009752:Nutritional Status; D010191:Pancreatic Polypeptide / Q000097:blood*; D019894:Peptide YY / Q000097:blood; D011178:Postgastrectomy Syndromes / Q000097:blood* / Q000473:pathology; D013552:Swine
D009478:Neuropeptide Y; D019894:Peptide YY; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin