Gender and metabolic differences of gallstone diseases.
OBJECTIVE
To investigate the risk factors for gallstone disease in the general population of Chengdu, China.


METHODS
This study was conducted at the West China Hospital. Subjects who received a physical examination at this hospital between January and December 2007 were included. Body mass index, blood pressure, fasting plasma glucose, serum lipid and lipoproteins concentrations were analyzed. Gallstone disease was diagnosed by ultrasound or on the basis of a history of cholecystectomy because of gallstone disease. Unconditional logistic regression analysis was used to investigate the risk factors for gallstone disease, and the Chi-square test was used to analyze differences in the incidence of metabolic disorders between subjects with and without gallstone disease.


RESULTS
A total of 3573 people were included, 10.7% (384/3573) of whom had gallstone diseases. Multiple logistic regression analysis indicated that the incidence of gallstone disease in subjects aged 40-64 or >or= 65 years was significantly different from that in those aged 18-39 years (P < 0.05); the incidence was higher in women than in men (P < 0.05). In men, a high level of fasting plasma glucose was obvious in gallstone disease (P < 0.05), and in women, hypertriglyceridemia or obesity were significant in gallstone disease (P < 0.05).


CONCLUSIONS
We assume that age and sex are profoundly associated with the incidence of gallstone disease; the metabolic risk factors for gallstone disease were different between men and women.
Physical Examination Center, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Hui
H
Sun
Hong
H
Tang
Shan
S
Jiang
Li
L
Zeng
En-Qiang
EQ
Chen
Tao-You
TY
Zhou
You-Juan
YJ
Wang
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002681:China / Q000453:epidemiology; D005260:Female; D042882:Gallstones / Q000453:epidemiology / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult