Role of explorative laparoscopy to evaluate optimal candidates for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal mesothelioma.
BACKGROUND
Prognosis of peritoneal mesothelioma (PM) treated by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is closely related to the completeness of the surgical cytoreduction. The reliability of explorative laparoscopy (EL) in selecting patients with PM amenable to optimal combined treatment has never been specifically assessed.


METHODS
Thirty-three patients with PM underwent EL before CRS and closed-abdomen HIPEC with cisplatin and doxorubicin. EL effectiveness in predicting complete cytoreduction (residual tumour nodules < or = 2.5 mm) was analyzed.


RESULTS
At EL, peritoneal involvement was considered amenable to complete CRS in 30 out of 33 patients (91%). In this group, cytoreduction was complete in 29 patients and incomplete in one. Three patients were judged not amenable to complete CRS and subsequently were not able to undergo complete cytoreduction.


CONCLUSIONS
EL findings can integrate clinical and radiological information in the selection process of patients with PM for combined treatment.
Laterza
Barbara
B
Department of Surgery, National Cancer Institute, Milan, Italy.
Kusamura
Shigeki
S
Baratti
Dario
D
Oliva
Grazia Daniela
GD
Deraco
Marcello
M
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced; D010535:Laparoscopy / Q000379:methods*; D008654:Mesothelioma / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D018365:Neoplasm, Residual; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D015203:Reproducibility of Results; D055815:Young Adult