First came the link between phosphoinositides and Ca2+ signalling, and then a deluge of other phosphoinositide functions.
The link between phosphoinositide turnover and Ca(2+)-regulated cell processes goes back half a century, but only began to be understood in the 1970s. This article briefly outlines how the roles of these minority membrane lipids in Ca(2+) signalling and then in multifarious other biological processes were recognised during the latter half of the 20th century.
Michell
Robert H
RH
School of Biosciences, University of Birmingham, Birmingham, UK. r.h.michell@bham.ac.uk
D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism; D015398:Signal Transduction
D010716:Phosphatidylinositols; D015544:Inositol 1,4,5-Trisphosphate; D019869:Phosphatidylinositol 3-Kinases; D011493:Protein Kinase C; D002118:Calcium