Cerebral venous thrombosis treated with enoxaparin in an IUGR neonate with DIC.
BACKGROUND
The case of a term IUGR newborn who presented a cerebral vein thrombosis diagnosed by routine ultrasound brain scan, and confirmed by magnetic resonance imaging and magnetic resonance venography, is reported. A thrombosis of cortical cerebral veins and intracerebral haemorrhage in the right frontal paramedian region was observed.


METHODS
Treatment with enoxaparin was started at the initial dose of 0.5 mg/kg subcutaneously every 12 h and then at 1.25 mg/kg per 12 h in order to obtain anti-factor Xa levels between 0.5 and 1.0 U/ml. After hospital discharge, enoxaparin was continued for 2 months with a lower dose (1.8 mg/kg/die).


CONCLUSIONS
Treatment with enoxaparin was effective as demonstrated by a complete "restitutio ad integrum".
Neonatal Intensive Care Unit, Department of Critical Care Medicine and Surgery, Azienda Ospedaliera Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy. giovanna.bertini@unifi.it
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Bertini
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Perugi
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Dani
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Prisco
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Fonda
D000925:Anticoagulants / Q000627:therapeutic use*; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D002550:Cerebral Veins / Q000187:drug effects / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D004453:Echoencephalography; D017984:Enoxaparin / Q000627:therapeutic use*; D005260:Female; D005317:Fetal Growth Retardation; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D010690:Phlebography; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
D000925:Anticoagulants; D017984:Enoxaparin