Basic research models for the study of underlying mechanisms of electrical neuromodulation and ischemic heart-brain interactions.
The study of mechanisms of action underlying the use of electrical neuromodulation for angina and myocardial ischemia may illuminate heart-brain interactions that influence these conditions. To investigate these mechanisms of action, we initiated a neurocardiology program in the 1990s. This review discusses the experimental models we have studied to unravel the heart-brain interactions involved in the use of electrical neuromodulation for ischemic disease.
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. M.J.L.de.Jongste@Thorax.UMCG.nl
Mike J L
MJ
Dejongste
Gert J
GJ
Terhorst
Robert D
RD
Foreman
D000818:Animals; D001921:Brain / Q000503:physiopathology; D002415:Cats; D004195:Disease Models, Animal; D004558:Electric Stimulation; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications* / Q000503:physiopathology* / Q000523:psychology; D018377:Neurotransmitter Agents / Q000502:physiology*; D010146:Pain / Q000503:physiopathology* / Q000523:psychology; D051381:Rats
D018377:Neurotransmitter Agents