Platinum(II) catalysts for highly enantioselective 1,6-enyne cycloisomerizations. synthetic, structural, and catalytic studies.
A new family of cyclometalated (N-heterocyclic carbene)-Pt(II) complexes bearing monodentate phosphines as ancillary ligands has been designed for use as precatalysts in 1,6-enyne cycloisomerization reactions. Highly enantioselective skeletal rearrangements of allylpropargyl-tosylamide derivatives have been developed by using (S)-Ph-Binepine as the chiral auxiliary. Enantiomeric excesses up to 97% have been obtained.
Brissy
Delphine
D
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, 1 av. de la Terrasse, 91198 Gif-sur-Yvette, France.
Skander
Myriem
M
Jullien
Hélène
H
Retailleau
Pascal
P
Marinetti
Angela
A
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010984:Platinum / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D006573:Heterocyclic Compounds, 1-Ring; D009942:Organometallic Compounds; D010984:Platinum