Bullous pemphigoid precipitated by galantamine hydrobromide.
Bullous pemphigoid (BP) is an acquired autoimmune disease commonly attributed as idiopathic, especially in elderly patients, characterized by subepidermal vesicles and bullae with linear deposits of IgG autoantibodies and complement along the epidermal basement membrane. It also is now commonly accepted that BP can be caused by or associated with drug therapy. We report a case of drug-induced BP (DIBP) likely due to galantamine hydrobromide, a competitive and reversible acetylcholinesterase inhibitor used in the treatment of mild to moderate Alzheimer dementia.
Diab
Mohammad
M
The Ohio State University, Division of Dermatology, 4731 Cramblett Hall, 456 W 10th Ave, Columbus, OH 43210, USA. Mohammad.Diab@osumc.edu
Coloe
Jacquelyn
J
Bechtel
Mark A
MA
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D005702:Galantamine / Q000009:adverse effects*; D006801:Humans; D018697:Nootropic Agents / Q000009:adverse effects*; D010391:Pemphigoid, Bullous / Q000139:chemically induced* / Q000175:diagnosis
D018697:Nootropic Agents; D005702:Galantamine