Lessons learned from the study of JunB: new insights for normal and leukemia stem cell biology.
JunB is important in maintaining normal hematopoietic stem cell functions, but the mechanisms underlying its activity are not well understood. In the current issue of Cancer Cell, a study by Santaguida et al. provides new insights into JunB's function and the genesis of myeloid disease.
Guzman
Monica L
ML
James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA.
Jordan
Craig T
CT
D000818:Animals; D002454:Cell Differentiation; D007938:Leukemia / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology*; D016755:Proto-Oncogene Proteins c-jun / Q000502:physiology*
D016755:Proto-Oncogene Proteins c-jun