Prevalence of fluoroquinolone resistance among tuberculosis patients in Shanghai, China.
We determined the prevalence of fluoroquinolone resistance among the isolates of Mycobacterium tuberculosis from 605 pulmonary tuberculosis patients in Shanghai, China. Mutations in gyrA were found in 81.5% of phenotypically fluoroquinolone-resistant isolates and were used as a molecular marker of fluoroquinolone resistance. gyrA mutations were detected in 1.9% of strains pan-susceptible to first-line drugs and 25.1% of multidrug-resistant strains. Fluoroquinolone resistance was independently associated with resistance to at least one first-line drug and prior tuberculosis treatment.
Department of TB Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Peng
P
Xu
Xia
X
Li
Ming
M
Zhao
Xiaohong
X
Gui
Kathryn
K
DeRiemer
Sebastien
S
Gagneux
Jian
J
Mei
Qian
Q
Gao
D000995:Antitubercular Agents / Q000494:pharmacology*; D016022:Case-Control Studies; D002681:China; D027081:DNA Gyrase / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D024841:Fluoroquinolones / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D012189:Retrospective Studies; D012307:Risk Factors; D014376:Tuberculosis / Q000188:drug therapy / Q000382:microbiology*
D000995:Antitubercular Agents; D024841:Fluoroquinolones; D027081:DNA Gyrase