Prophylactic effect of administration of human gamma globulins in a mouse model of tuberculosis.
The protective effect of human gamma globulins on Mycobacterium tuberculosis infection was evaluated in a mouse model of intratracheal infection. Animals receiving human gamma globulins intranasally, 2h before intratracheal challenge showed a significant decrease in lung bacilli load compared to non-treated animals in different time intervals of up to 2 months after challenge. The same effect was obtained when M. tuberculosis was pre-incubated with the gamma globulin before challenge. The protective effect of the gamma-globulin formulation was abolished after pre-incubation with M. tuberculosis. These results suggest a potential role of specific antibodies in the defence against mycobacterial infections.
Olivares
Nesty
N
Department of Molecular Biology, Finlay Institute, Ave 27 No. 19805, La Lisa, Havana City, AP 16017, CP 11600, Cuba.
Puig
Alina
A
Aguilar
Diana
D
Moya
Aniel
A
Cádiz
Armando
A
Otero
Oscar
O
Izquierdo
Luis
L
Falero
Gustavo
G
Solis
Rosa L
RL
Orozco
Hector
H
Sarmiento
Maria E
ME
Norazmi
Mohd Nor
MN
Hernández-Pando
Rogelio
R
Acosta
Armando
A
D000281:Administration, Intranasal; D000818:Animals; D015169:Colony Count, Microbial; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification; D014397:Tuberculosis, Pulmonary / Q000382:microbiology / Q000517:prevention & control*; D005719:gamma-Globulins / Q000008:administration & dosage* / Q000276:immunology
D007155:Immunologic Factors; D005719:gamma-Globulins