Clear cell sarcoma of the stomach.
Clear cell sarcoma (CCS) is a high grade soft tissue sarcoma with a distinct molecular profile. Gastrointestinal CCS is very rare and most reported cases are in adults. We describe a 10-year-old female with a 4-month history of anemia who later developed fever, weight loss and abdominal pain. She was subsequently found to have a large infiltrative gastric mass. A diagnosis of CCS was confirmed by molecular and cytogenetic studies. This case illustrates the necessity of a multimodal approach, particularly the use of molecular studies, in the diagnostic evaluation of rare tumors presenting in unusual sites.
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA. lagmayj@chi.osu.edu
Joanne P
JP
Lagmay
Mark
M
Ranalli
Maria
M
Arcila
Peter
P
Baker
D000971:Antineoplastic Combined Chemotherapy Protocols; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005743:Gastrectomy; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011878:Radiotherapy; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018227:Sarcoma, Clear Cell / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D014157:Transcription Factors / Q000235:genetics
C111598:EWS-ATF1 fusion protein, human; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors