High-molecular weight adiponectin is associated with coronary artery angiographic findings in Asian Indians.
Asian Indians (AIs) have a higher prevalence and a more aggressive form of coronary artery disease (CAD), and it has been suggested that hypoadiponectinemia may have a role in this accelerated CAD. The present study was undertaken to determine the extent and severity of angiographic findings in 2 groups of CAD patients matched for age and sex, AIs (n = 29) vs whites (n = 30), and to elucidate the potential relationship between adiponectin (total and high-molecular weight [HMW] form) and the severity and extent of coronary angiographic findings in both groups. Angiographic findings were assessed using the modified Gensini index; and 2 scores, scores 1 and 2, were used to assess the severity and extent. Both Gensini index scores 1 and 2 were higher in the AI group compared with the white group (144.4 +/- 87.1 vs 93.5 +/- 56.3 and 127.2 +/- 86.5 vs 80.1 +/- 39.3, respectively; P < .05). Adiponectin levels were similar in both groups. Total adiponectin and HMW adiponectin were positively associated with Gensini index score 1 (r = 0.62, P = .004 and r = 0.64, P = .003) and score 2 (r = 0.51, P = .021 and r = 0.54, P = .013), respectively, in AI men, whereas there was no significant association in white men. Thus, AIs had more severe CAD compared with whites; and in AI men with CAD, total adiponectin and HMW adiponectin were associated with the severity of angiographic scores.
Metabolic Unit and Department of Medicine, Kaplan Medical Center, Rehovot and the Hebrew University Hadassah Medical School, Rehovot, Israel.
Taiba
T
Zornitzki
Naama
N
Reshef
Oded
O
Ayzenberg
Rinat
R
Cohen
Gera
G
Gandelman
J Jan
JJ
Frystyk
Allan
A
Flyvbjerg
Hilla
H
Knobler
D052242:Adiponectin / Q000378:metabolism; D000368:Aged; D016022:Case-Control Studies; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007194:India / Q000208:ethnology; D007557:Israel; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018709:Statistics, Nonparametric
C499918:ADIPOQ protein, human; D052242:Adiponectin