A dual DTI approach to analyzing white matter in children with dyslexia.
Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities.
Center for Genetic Disorders of Cognition & Behavior, Kennedy Krieger Institute, Baltimore, MD, United States.
John C
JC
Carter
Diane C
DC
Lanham
Laurie E
LE
Cutting
Amy M
AM
Clements-Stephens
Xuejing
X
Chen
Muhamed
M
Hadzipasic
Joon
J
Kim
Martha B
MB
Denckla
Walter E
WE
Kaufmann
D000293:Adolescent; D016880:Anisotropy; D001921:Brain / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging; D004410:Dyslexia / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009434:Neural Pathways / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology