Central pontine and extrapontine myelinolysis.
At the crossover of specialties, the osmotic demyelination syndromes are under-diagnosed clinical entities. Even if the knowledge and the management of these entities have evolved in the latest years, many issues are still unsolved. Initially described as diseases affecting alcoholics and malnourished and considered affecting solely the pons, it is now known that osmotic demyelination can produce extrapontine lesions (extrapontine myelinolysis). Rapid correction of sodium in hyponatremic patients is pathogenically involved in the genesis of central pontine and extrapontine myelinolysis. The aim of this review is to focus on the main characteristics of the disease, which can represent a challenge for the clinicians in respect to its recognition and treatment.
University of Medicine and Pharmacy Carol Davila, Bucharest, Romania. neuradutanasescu@gmail.com
R
R
Tănăsescu
Marina
M
Ticmeanu
Inimioara Mihaela
IM
Cojocaru
Dimela
D
Luca
Adriana
A
Nicolau
Adriana
A
Hristea
C
C
Băicuş
D006801:Humans; D007010:Hyponatremia / Q000150:complications / Q000628:therapy*; D007262:Infusions, Intravenous / Q000009:adverse effects; D017590:Myelinolysis, Central Pontine / Q000209:etiology* / Q000503:physiopathology; D012965:Sodium Chloride / Q000008:administration & dosage / Q000009:adverse effects; D014882:Water-Electrolyte Balance / Q000502:physiology
D012965:Sodium Chloride