High prevalence of qnr genes in commensal enterobacteria from healthy children in Peru and Bolivia.
A remarkable prevalence of qnrB (54%) and, at a lower level, of qnrS (14%) was discovered in pools of commensal enterobacteria from 310 healthy children living in Peru and Bolivia, using a metagenomic approach. Analysis of randomly selected enterobacterial pools revealed that qnrB was mainly carried by Escherichia coli and qnrS by Klebsiella pneumoniae. Investigation of 11 qnrB-positive isolates and 9 qnrS-positive isolates revealed the presence of plasmid-borne qnrB19 (n = 8), qnrB2 (n = 2), qnrB10 (n = 1), and qnrS1 (n = 9) genes.
Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, 53100 Siena, Italy.
Lucia
L
Pallecchi
Eleonora
E
Riccobono
Antonia
A
Mantella
Filippo
F
Bartalesi
Samanta
S
Sennati
Herlan
H
Gamboa
Eduardo
E
Gotuzzo
Alessandro
A
Bartoloni
Gian Maria
GM
Rossolini
D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D001838:Bolivia; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics*; D006801:Humans; D007223:Infant; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics; D008969:Molecular Sequence Data; D010568:Peru; D010957:Plasmids; D016133:Polymerase Chain Reaction; D015363:Quinolones / Q000494:pharmacology*
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C485384:Qnr protein, E coli; C485385:Qnr protein, Klebsiella pneumoniae; D015363:Quinolones