Antimony(III) chloride catalyzed direct three component one-pot Mannich reaction.
Antimony(III) chloride catalyzes the three component Mannich type reaction of a variety of in-situ generated Schiff bases generated from aromatic aldehydes and anilines with cyclic/acyclic ketones. The reaction proceeds smoothly at ambient temperature to afford the corresponding beta-amino ketones in good yields with moderate to good diastereoselectivity.
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai-400085, India.
Prashant
P
Shukla
Nilmadhab
N
Chattopadhyay
Sandip K
SK
Nayak
D000447:Aldehydes / Q000737:chemistry; D000965:Antimony / Q000737:chemistry*; D002384:Catalysis; D008352:Mannich Bases / Q000737:chemistry*; D015394:Molecular Structure
D000447:Aldehydes; D008352:Mannich Bases; D000965:Antimony