A s-myly route toward lymphoid differentiation.
In this issue of Immunity, Ng et al. (2009) show that lymphoid-lineage priming occurs in hematopoietic stem cells and is dependent on the Ikaros transcription factor, as is repression of self-renewal genes during lymphoid differentiation.
Kee
Barbara L
BL
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA. bkee@bsd.uchicago.edu
Dias
Sheila
S
D002454:Cell Differentiation; D019070:Cell Lineage / Q000502:physiology*; D051740:Ikaros Transcription Factor / Q000378:metabolism; D054503:Lymphoid Progenitor Cells / Q000166:cytology* / Q000276:immunology*; D022423:Myeloid Cells / Q000276:immunology
D051740:Ikaros Transcription Factor