Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy.
We describe an application of plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia in tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom and laboratory rats. Temperature distributions on the animal skin surface at hypodermic and intramuscular injection of gold nanoparticle suspensions and affectations by the laser radiation are measured in vivo with a thermal imaging system. The results of temperature measurements are compared with tissue histology.
Terentyuk
Georgy S
GS
Saratov State University, Department of Optics and Biophotonics, 83 Astrakhanskaya, Saratov 410012, Russia.
Maslyakova
Galina N
GN
Suleymanova
Leyla V
LV
Khlebtsov
Nikolai G
NG
Khlebtsov
Boris N
BN
Akchurin
Garif G
GG
Maksimova
Irina L
IL
Tuchin
Valery V
VV
D003198:Computer Simulation; D006046:Gold / Q000528:radiation effects* / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007834:Lasers; D008954:Models, Biological; D053758:Nanoparticles / Q000528:radiation effects* / Q000627:therapeutic use*; D010789:Phototherapy / Q000379:methods*
D006046:Gold