title: Subtyping and env C2/V3 sequence analysis of HIV-1 isolated from HIV-infected children hospitalized in Children Hospital 1, Vietnam during 2004-2005.
abstract: A molecular epidemiological study was conducted on 104 HIV-1 strains isolated from HIV-infected children hospitalized in Children Hospital 1 in Ho Chi Minh City, Vietnam during 2004-2005. Genetic subtyping based on env C2/V3 sequences revealed that CRF01-AE was the sole circulating recombinant form found in this study. Sequence analysis of the V3 loop showed that GPGQ tetramer was the most common V3 loop core motif identified in the HIV-1 strains studied (89.5%). The findings raise great concern about HIV-infected children in Vietnam and provide up-to-date molecular epidemiological information of HIV-1 circulating in Vietnam during the study period.
authors.affiliation: Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, the University of Tokyo, Japan.
authors.forename: Quang Duy
authors.initials: QD
authors.lastname: Trinh
authors.forename: Ngan Thi Kim
authors.initials: NT
authors.lastname: Pham
authors.forename: Bao Quoc
authors.initials: BQ
authors.lastname: Lam
authors.forename: Thoa Phan Kim
authors.initials: TP
authors.lastname: Le
authors.forename: Khanh Huu
authors.initials: KH
authors.lastname: Truong
authors.forename: Thinh Quoc
authors.initials: TQ
authors.lastname: Le
authors.forename: Hung Thanh
authors.initials: HT
authors.lastname: Vo
authors.forename: Thuong Chi
authors.initials: TC
authors.lastname: Tang
authors.forename: Tuan Manh
authors.initials: TM
authors.lastname: Ha
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Izumi
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizuguchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayakawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ushijima
mesh_terms: D000595:Amino Acid Sequence; D002675:Child, Preschool; D005260:Female; D015752:Genes, env / Q000235:genetics*; D015750:Genes, gag / Q000235:genetics*; D015751:Genes, pol / Q000235:genetics*; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000235:genetics; D016415:Sequence Alignment; D014744:Vietnam / Q000453:epidemiology