title: High power accelerator-based boron neutron capture with a liquid lithium target and new applications to treatment of infectious diseases.
abstract: A new conceptual design for an accelerator-based boron neutron capture therapy (ABNCT) facility based on the high-current low-energy proton beam driven by the linear accelerator at SARAF (Soreq Applied Research Accelerator Facility) incident on a windowless forced-flow liquid-lithium target, is described. The liquid-lithium target, currently in construction at Soreq NRC, will produce a neutron field suitable for the BNCT treatment of deep-seated tumor tissues, through the reaction (7)Li(p,n)(7)Be. The liquid-lithium target is designed to overcome the major problem of solid lithium targets, namely to sustain and dissipate the power deposited by the high-intensity proton beam. Together with diseases conventionally targeted by BNCT, we propose to study the application of our setup to a novel approach in treatment of diseases associated with bacterial infections and biofilms, e.g. inflammations on implants and prosthetic devices, cystic fibrosis, infectious kidney stones. Feasibility experiments evaluating the boron neutron capture effectiveness on bacteria annihilation are taking place at the Soreq nuclear reactor.
authors.affiliation: Soreq NRC, Yavne 81800, Israel. halfon@phys.huji.ac.il
authors.forename: S
authors.initials: S
authors.lastname: Halfon
authors.forename: M
authors.initials: M
authors.lastname: Paul
authors.forename: D
authors.initials: D
authors.lastname: Steinberg
authors.forename: A
authors.initials: A
authors.lastname: Nagler
authors.forename: A
authors.initials: A
authors.lastname: Arenshtam
authors.forename: D
authors.initials: D
authors.lastname: Kijel
authors.forename: I
authors.initials: I
authors.lastname: Polacheck
authors.forename: M
authors.initials: M
authors.lastname: Srebnik
mesh_terms: D001424:Bacterial Infections / Q000532:radiotherapy*; D018441:Biofilms / Q000528:radiation effects; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods*; D005160:Facility Design and Construction; D005214:Fast Neutrons / Q000627:therapeutic use; D006801:Humans; D007557:Israel; D008094:Lithium / Q000528:radiation effects; D009369:Neoplasms / Q000532:radiotherapy; D010315:Particle Accelerators
chemical_list: D008094:Lithium