title: Ubiquitin connects with planar cell polarity.
abstract: Planar cell polarity (PCP) regulates the orientation of cells in epithelia and of mesenchymal cells during gastrulation. In this issue, Narimatsu et al. (2009) report that the Smurf E3 ubiquitin ligases are required for localized protein degradation of a core PCP factor to generate cellular asymmetry.
authors.affiliation: Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA. marek.mlodzik@mssm.edu
authors.forename: Marek
authors.initials: M
authors.lastname: Mlodzik
mesh_terms: D000818:Animals; D016764:Cell Polarity; D003051:Cochlea / Q000196:embryology*; D004330:Drosophila; D054262:Gastrulation; D051379:Mice; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014921:Wings, Animal / Q000196:embryology
chemical_list: D044767:Ubiquitin-Protein Ligases