Apolipoprotein A-V is a potent modulator of HDL and VLDL components in preadolescent children.
OBJECTIVE
Mice lacking apolipoprotein A-V (apoA-V) displayed an increase in serum triglyceride (TG) levels; however, the correlation of apoA-V levels with TG levels in humans is controversial, and the exact mechanism by which apoA-V affects TG levels is unclear. The aim of the present study was to clarify the impact of apoA-V on the lipoprotein subclass profile in preadolescent children, which has not been studied.


METHODS
The study subjects were 178 (89 male, 89 female) 4th grade elementary school children (mean+/-SD: 9.5+/-0.5 years old). ApoA-V levels were determined by an enzyme-linked immunosorbent assay, and the lipid component of each lipoprotein fraction and their particle sizes were measured by HPLC.


RESULTS
Levels of apoA-V showed no gender difference in preadolescent children, and were not affected by anthropometric variables. ApoA-V had a negative association with serum TG levels and TG levels in each lipoprotein fraction, and a positive association with HDL-C. In particular, apoA-V appears to contribute to the increase in cholesterol levels in the larger HDL fraction.


CONCLUSIONS
It was suggested that apoA-V is a potent modulator of HDL and VLDL components in preadolescent children.
Abe
Yuriko
Y
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Okada
Tomoo
T
Kuromori
Yuki
Y
Hara
Mitsuhiko
M
Saito
Emiko
E
Iwata
Fujihiko
F
Harada
Kensuke
K
Mugishima
Hideo
H
D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000097:blood*; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D010316:Particle Size; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol