title: Synthesis of novel cholesterol-based cationic lipids for gene delivery.
abstract: The new cholesterol-based cationic lipids B, C, and D with an ether linked spacer were synthesized by using aminopropyl chain extension with acrylonitrile. The cholesterol-based cationic lipid A with carbamoyl linkage were also synthesized in order to compare the difference in transfection efficiency of the two linkage types. To this end, GFP expression of these cationic lipids was confirmed respectively.
authors.affiliation: School of Life Sciences and Biotechnology, Kyungpook National University, Sankyukdong, Bookgu, Daegu, Republic of Korea.
authors.forename: Bieong-Kil
authors.initials: BK
authors.lastname: Kim
authors.forename: Kyung-Oh
authors.initials: KO
authors.lastname: Doh
authors.forename: Joo Hyeung
authors.initials: JH
authors.lastname: Nam
authors.forename: Hyungu
authors.initials: H
authors.lastname: Kang
authors.forename: Jong-Gu
authors.initials: JG
authors.lastname: Park
authors.forename: Ik-Jae
authors.initials: IJ
authors.lastname: Moon
authors.forename: Young-Bae
authors.initials: YB
authors.lastname: Seu
mesh_terms: D002412:Cations / Q000737:chemistry*; D045744:Cell Line, Tumor; D002784:Cholesterol / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008081:Liposomes / Q000737:chemistry; D014162:Transfection
chemical_list: D002412:Cations; D008055:Lipids; D008081:Liposomes; D002784:Cholesterol