title: Early prediction of long-term cognitive impairment after cardiac arrest.
abstract: This prospective study evaluated the prognostic value of early neurobiochemical markers, neuron-specific enolase and astroglial protein S-100B, for long-term cognitive outcome after cardiac arrest. Six months after admission of a cohort of 80 consecutive patients, 26 survivors were able to undergo a neuropsychological test battery. Survivors showed low test performances in attention, learning/memory, and executive functioning. Neuropsychological bedside screening during the first month significantly differentiated between patients with and without long-term cognitive impairment. The neurobiochemical marker S-100B at day 3 after admission was found to predict significant proportions of variance in specific cognitive domains (learning/memory and executive functioning). The results indicate that early neuropsychological assessment might help identify patients who run at risk of long-term neuropsychological dysfunction. This study also suggests that especially the protein S-100B provides valuable information on long-term cognitive outcomes. To understand the exact relationship, results have to be replicated in larger trials.
authors.affiliation: Department of Cognitive Rehabilitation, Neurological Rehabilitation Center Godeshöhe, Academic Teaching Hospital, University of Bonn, Bonn, Germany. joern.prohl@t-online.de
authors.forename: Jörn
authors.initials: J
authors.lastname: Prohl
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bodenburg
authors.forename: Stephan Jeff
authors.initials: SJ
authors.lastname: Rustenbach
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000378:metabolism; D015331:Cohort Studies; D005260:Female; D006323:Heart Arrest / Q000150:complications* / Q000378:metabolism; D006801:Humans; D007858:Learning / Q000502:physiology; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D009414:Nerve Growth Factors / Q000097:blood; D009483:Neuropsychological Tests; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011237:Predictive Value of Tests; D011340:Problem Solving / Q000502:physiology; D012372:ROC Curve; D012044:Regression Analysis; D012189:Retrospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase