Mitochondrial and cell-surface F0F1ATPsynthase in innate and acquired cardioprotection.
Mitochondria are central to heart function and dysfunction, and the pathways activated by different cardioprotective interventions mostly converge on mitochondria. In a context of perspectives in innate and acquired cardioprotection, we review some recent advances in F(0)F(1)ATPsynthase structure/function and regulation in cardiac cells. We focus on three topics regarding the mitochondrial F(0)F(1)ATPsynthase and the plasma membrane enzyme, i.e.: i) the crucial role of cardiac mitochondrial F(0)F(1)ATPsynthase regulation by the inhibitory protein IF(1) in heart preconditioning strategies; ii) the structure and function of mitochondrial F(0)F(1)ATPsynthase oligomers in mammalian myocardium as possible endogenous factors of mitochondria resistance to ischemic insult; iii) the external location and characterization of plasma membrane F(0)F(1) ATP synthase in search for possible actors of its regulation, such as IF(1) and calmodulin, at cell surface.
Lippe
Giovanna
G
Department of Biomedical Sciences and Technologies and M.A.T.I. Centre of Excellence, University of Udine, P.le Kolbe 4, 33100, Udine, Italy.
Bisetto
Elena
E
Comelli
Marina
M
Contessi
Stefania
S
Di Pancrazio
Francesca
F
Mavelli
Irene
I
D000818:Animals; D002147:Calmodulin / Q000737:chemistry / Q000378:metabolism; D002462:Cell Membrane / Q000737:chemistry / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D008929:Mitochondria, Heart / Q000737:chemistry / Q000201:enzymology* / Q000473:pathology; D017202:Myocardial Ischemia / Q000201:enzymology* / Q000473:pathology; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D020836:Protein Structure, Quaternary; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D006180:Proton-Translocating ATPases / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D000097795:ATPase Inhibitory Protein
D002147:Calmodulin; D011506:Proteins; D006180:Proton-Translocating ATPases; D000097795:ATPase Inhibitory Protein