Boron neutron capture therapy for an explanted organ: the logistical challenges.
Single liver metastases of colorectal cancer can be cured by surgery; disseminated liver metastases are incurable. A research group in Pavia, Italy, used BNCT as an experimental method to irradiate in curative intention the explanted liver of patients suffering from disseminated hepatic metastases. The situation in Pavia, where a reactor with a specially adapted thermal column and the hospital are close by, is unique. For the purpose of the present study, it was necessary to investigate how the Pavia experience can be repeated with transplantation centers located at distance from a reactor. Some basic investigations of the logistics of such a procedure are reported.
Wittig
A
A
Department of Radiation Oncology, University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, Essen, Germany. andrea.wittig@uni-due.de
Moss
R
R
Kaiser
G M
GM
Malago
M
M
Nievaart
V
V
Sauerwein
W A
WA
D000818:Animals; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation / Q000379:methods*; D015179:Colorectal Neoplasms; D006801:Humans; D066298:In Vitro Techniques; D007558:Italy; D008099:Liver / Q000528:radiation effects; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary* / Q000601:surgery; D016031:Liver Transplantation; D023421:Models, Animal; D009926:Organ Preservation; D013552:Swine; D014182:Transplantation, Autologous