title: Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA termini.
abstract: Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA-peptide conjugates that mimic peptidyl-tRNA would be desirable, especially for ribosome structural biology. A flexible solid-phase synthesis strategy now allows efficient access to these highly requested derivatives without restriction on the RNA and peptide sequences.
authors.affiliation: Institute of Organic Chemistry, Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
authors.forename: Holger
authors.initials: H
authors.lastname: Moroder
authors.forename: Jessica
authors.initials: J
authors.lastname: Steger
authors.forename: Dagmar
authors.initials: D
authors.lastname: Graber
authors.forename: Katja
authors.initials: K
authors.lastname: Fauster
authors.forename: Krista
authors.initials: K
authors.lastname: Trappl
authors.forename: Viter
authors.initials: V
authors.lastname: Marquez
authors.forename: Norbert
authors.initials: N
authors.lastname: Polacek
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Wilson
authors.forename: Ronald
authors.initials: R
authors.lastname: Micura
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D006868:Hydrolysis; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*; D014176:Protein Biosynthesis; D012313:RNA / Q000737:chemistry*; D012346:RNA, Transfer, Amino Acyl / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010455:Peptides; D012346:RNA, Transfer, Amino Acyl; C019037:tRNA, peptidyl-; D012313:RNA