title: Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population.
abstract: The neuregulin 1 gene (NRG1) has been identified as a candidate gene for schizophrenia in a linkage study in the Icelandic population. Recent evidence also suggested that it might be related to the neurodevelopmental hypothesis and glutamate hypothesis for schizophrenia. Because the symptomatology of methamphetamine (METH) use disorder with accompanying psychosis is similar to that of patients with schizophrenia, NRG1 is an appropriate candidate gene for METH-induced psychosis. We conducted a case-control association study between NRG1 and METH-induced psychosis in a Japanese population (184 subjects with METH-induced psychosis and 534 controls). Written informed consent was obtained from each subject. We selected four SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177, and rs3924999) in NRG1 from previous reports. No significant association was found between NRG1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population.
authors.affiliation: Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan. t-okochi@fujita-hu.ac.jp
authors.forename: Tomo
authors.initials: T
authors.lastname: Okochi
authors.forename: Taro
authors.initials: T
authors.lastname: Kishi
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kitajima
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Kawashima
authors.forename: Takenori
authors.initials: T
authors.lastname: Okumura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tsunoka
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Yamada
authors.forename: Naohisa
authors.initials: N
authors.lastname: Uchimura
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sora
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000235:genetics* / Q000523:psychology; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D008875:Middle Aged; D020890:Neuregulin-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000235:genetics* / Q000523:psychology; D055815:Young Adult
chemical_list: C094131:NRG1 protein, human; D020890:Neuregulin-1; D008694:Methamphetamine