Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population.
The neuregulin 1 gene (NRG1) has been identified as a candidate gene for schizophrenia in a linkage study in the Icelandic population. Recent evidence also suggested that it might be related to the neurodevelopmental hypothesis and glutamate hypothesis for schizophrenia. Because the symptomatology of methamphetamine (METH) use disorder with accompanying psychosis is similar to that of patients with schizophrenia, NRG1 is an appropriate candidate gene for METH-induced psychosis. We conducted a case-control association study between NRG1 and METH-induced psychosis in a Japanese population (184 subjects with METH-induced psychosis and 534 controls). Written informed consent was obtained from each subject. We selected four SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177, and rs3924999) in NRG1 from previous reports. No significant association was found between NRG1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population.
Okochi
Tomo
T
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan. t-okochi@fujita-hu.ac.jp
Kishi
Taro
T
Ikeda
Masashi
M
Kitajima
Tsuyoshi
T
Kinoshita
Yoko
Y
Kawashima
Kunihiro
K
Okumura
Takenori
T
Tsunoka
Tomoko
T
Inada
Toshiya
T
Yamada
Mitsuhiko
M
Uchimura
Naohisa
N
Iyo
Masaomi
M
Sora
Ichiro
I
Ozaki
Norio
N
Ujike
Hiroshi
H
Iwata
Nakao
N
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000235:genetics* / Q000523:psychology; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D008875:Middle Aged; D020890:Neuregulin-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000235:genetics* / Q000523:psychology; D055815:Young Adult
C094131:NRG1 protein, human; D020890:Neuregulin-1; D008694:Methamphetamine