Characterization of three novel HLA alleles, HLA-B*4613, HLA-B*4614 and HLA-B*4618, in Chinese individuals.
Three novel alleles, human leukocyte antigen (HLA)-B*4613, HLA-B*4614 and HLA-B*4618, were identified in Chinese individuals. HLA-B*4613 shows four nucleotides difference from B*460101, resulting in two amino acids change from Glu to Val at codon 152 and Trp to Leu at codon 156. HLA-B*4614 has a single nucleotide difference at position 97 T-->C compared with HLA-B*460101, with an amino acid change from Tyr to His at codon 9. HLA-B*4618 shares the sequence of exon 2 with B*4601 and sequences of exons 3 and 4 with B*55, B*54 or B*59, together resulting in eight amino acids change compared with HLA-B*460101.
Yan
L-X
LX
HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang Province, China. qxk@zjb.org.cn
Zhu
F-M
FM
Zhang
W
W
He
J
J
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002681:China; D005091:Exons / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D015235:HLA-B Antigens