Efficient synthesis of Idraparinux, the anticoagulant pentasaccharide.
An efficient [DEF+GH] route was developed to the synthesis of Idraparinux, which is a fully O-sulfated, O-methylated mimic of the unique Antithrombin III binding domain of heparin.
Chen
Chen
C
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Yu
Biao
B
D000925:Anticoagulants / Q000138:chemical synthesis* / Q000737:chemistry; D000990:Antithrombin III / Q000737:chemistry; D006031:Glycosylation; D006493:Heparin / Q000737:chemistry; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry
D000925:Anticoagulants; D009844:Oligosaccharides; C479958:idraparinux; D000990:Antithrombin III; D006493:Heparin