title: Correcting autoimmune anomalies in autoimmune disorders by immunological means, employing the modified vaccination technique.
abstract: Our research group has developed a new vaccination technique in experimental animals that has the potential of correcting autoimmune anomalies in humans such as autoimmune disorders, cancer, and chronic infections, both prophylactically and therapeutically. The vaccination method is called Modified Vaccination Technique (MVT). The MVT necessitates the introduction of a purified target antigen (ag) and a specific antibody (ab) against the target ag in the form of immune complex (IC) to evoke the desired immune response outcome by ab information transfer in the injected recipient. The injected IC produces the same class of ab in the host, with the same specificity against the target ag, as resides in the inoculum. The MVT promises to provide a means of upregulating beneficial immune events and downregulating undesirable immune responses in individuals, thereby re-establishing normalcy/tolerance to self.
authors.affiliation: Department of Surgery, University of Calgary, Calgary, Alberta, Canada. barabas@ucalgary.ca
authors.forename: Arpad Zsigmond
authors.initials: AZ
authors.lastname: Barabas
authors.forename: Chad Douglas
authors.initials: CD
authors.lastname: Cole
authors.forename: Arpad David
authors.initials: AD
authors.lastname: Barabas
authors.forename: Richard Milton
authors.initials: RM
authors.lastname: Graeff
authors.forename: Rene
authors.initials: R
authors.lastname: Lafreniere
authors.forename: Donald Mackay
authors.initials: DM
authors.lastname: Weir
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy*; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control; D017634:Self Tolerance; D014611:Vaccination / Q000379:methods*
chemical_list: D000936:Antigen-Antibody Complex