Synthesis and characterization of hyperbranched poly(glycidol) modified with pH- and temperature-sensitive groups.
Hyperbranched poly(glycidol)s with varying degrees of polymerization were modified by reaction with succinic anhydride and isopropylamine to obtain novel pH- and thermosensitive polymers. These polymers exhibited phase transitions in response to decreasing pH and/or increasing temperature, depending on the degree of polymerization and the ratio of succinyl group to N-isopropylamide. It was possible to harvest a bioactive molecule, rose bengal, from solution using the phase transition of thermosensitive hyperbranched poly(glycidol).
Kojima
Chie
C
Department of Applied Chemistry, Osaka Prefecture University, Osaka, Japan.
Yoshimura
Kohei
K
Harada
Atsushi
A
Sakanishi
Yuichi
Y
Kono
Kenji
K
D000178:Acrylamides / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D044367:Phase Transition; D011409:Propylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry*; D012395:Rose Bengal / Q000302:isolation & purification; D019802:Succinic Acid / Q000737:chemistry; D013696:Temperature
D000178:Acrylamides; D020099:Coated Materials, Biocompatible; D011409:Propylene Glycols; C502907:polyglycidol; D012395:Rose Bengal; D019802:Succinic Acid; C067295:N-isopropylacrylamide