title: The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.
abstract: OBJECTIVE
  Previous studies have demonstrated that the PRL -1149 T (minor) allele decreases prolactin expression and may be associated with autoimmune disease. The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility.
  
  
  METHODS
  We examined the association between PRL -1149 G/T and RA risk in 4 separate study populations, consisting of a total of 3,405 RA cases and 4,111 controls of self-reported white European ancestry. Samples were genotyped using 1 of 3 genotyping platforms, and strict quality control metrics were applied. We tested for association using a 2-tailed Cochran-Mantel-Haenszel additive, fixed-effects model.
  
  
  RESULTS
  In the individual populations, odds ratios (ORs) for an association between PRL -1149 T and RA risk ranged from 0.80 to 0.97. In a joint meta-analysis across all 4 populations, the OR for an association between PRL -1149 T and RA risk was 0.90 (95% confidence interval 0.84-0.96, P=0.001).
  
  
  CONCLUSIONS
  Our findings indicate a possible association between the PRL -1149 T allele and decreased RA risk. The effect size is small but similar to ORs for other genetic polymorphisms associated with complex traits, including RA.
authors.affiliation: Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. ylee9@partners.org
authors.forename: Yvonne C
authors.initials: YC
authors.lastname: Lee
authors.forename: Soumya
authors.initials: S
authors.lastname: Raychaudhuri
authors.forename: Jing
authors.initials: J
authors.lastname: Cui
authors.forename: Immaculata
authors.initials: I
authors.lastname: De Vivo
authors.forename: Bo
authors.initials: B
authors.lastname: Ding
authors.forename: Lars
authors.initials: L
authors.lastname: Alfredsson
authors.forename: Leonid
authors.initials: L
authors.lastname: Padyukov
authors.forename: Karen H
authors.initials: KH
authors.lastname: Costenbader
authors.forename: Mark
authors.initials: M
authors.lastname: Seielstad
authors.forename: Robert R
authors.initials: RR
authors.lastname: Graham
authors.forename: Lars
authors.initials: L
authors.lastname: Klareskog
authors.forename: Peter K
authors.initials: PK
authors.lastname: Gregersen
authors.forename: Robert M
authors.initials: RM
authors.lastname: Plenge
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Karlson
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011388:Prolactin / Q000235:genetics*
chemical_list: D011388:Prolactin