title: The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men.
abstract: The Toll-like receptor 4 (TLR4) has a wide spectrum of bacteria recognition receptors that may be involved in the signaling of the immune responses in the prostate. A few association studies have assessed the relationship between the risk of prostate cancer (PC) and the polymorphism in the TLR4 gene in European-ancestry populations. To evaluate the association of TLR4 polymorphisms and the risk for PC in Korean men, we genotyped five single-nucleotide polymorphisms (SNPs) of the TRL4 gene (rs11536858, rs1927914, 1927911, rs11536891, and rs11536897) by PCR-restriction fragment length polymorphism from unrelated 157 PC patients and 143 age-matched controls. The rs1927911 SNP increased the risk of PC (adjusted odds ratio ORadj=2.73, 95% CI=1.54-4.87 for the TC genotype; ORadj=6.68, 95% CI=3.27-13.66 for the CC genotype). The GG genotype of the rs11536858 SNP also carried increased risk (ORadj=2.296, 95% CI=1.07-4.93). There was no statistically significant correlation between any of the SNPs of TRL4 and such PC prognostic factors as Gleason grade, initial prostate-specific antigen level, or tumor stage. In conclusion, inherited differences in the TLR4 gene influence the risk of PC in Korean men.
authors.affiliation: Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Jaemann
authors.initials: J
authors.lastname: Song
authors.forename: Duk Yoon
authors.initials: DY
authors.lastname: Kim
authors.forename: Choung Soo
authors.initials: CS
authors.lastname: Kim
authors.forename: Hyung Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Dong Hyeon
authors.initials: DH
authors.lastname: Lee
authors.forename: Hyun Moo
authors.initials: HM
authors.lastname: Lee
authors.forename: Woojin
authors.initials: W
authors.lastname: Ko
authors.forename: Gilho
authors.initials: G
authors.lastname: Lee
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D006801:Humans; D007723:Korea; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D051197:Toll-Like Receptor 4 / Q000235:genetics* / Q000378:metabolism
chemical_list: C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4