Morphofunctional characteristics of ACTH cells in middle-aged male rats after treatment with genistein.
The soybean phytoestrogen, genistein, is increasingly consumed as an alternative therapeutic for age-related diseases. The aim of this study was to examine the morphofunctional characteristics of adrenocorticotrophic (ACTH) cells and blood concentrations of ACTH in sham-operated, orchidectomized and genistein-treated orchidectomized, 16-month-old Wistar male rats. Genistein (10 mg/kg/day) was administered subcutaneously for three weeks, while the control groups received the vehicle alone. Orchidectomy and genistein treatment decreased the volume density of ACTH cells and reduced (p < 0.05) circulating ACTH concentrations in comparison with control groups. In conclusion, genistein modulated the morphofunctional features of ACTH cells and decreased blood ACTH levels.
Milosević
Verica Lj
VLj
Institute for Biological Research "Sinisa Stanković", 142 Despot Stefan Blvd., 11060 Belgrade, Serbia. dimi@ibiss.bg.ac.yu
Ajdzanović
Vladimir Z
VZ
Sosić-Jurjević
Branka T
BT
Filipović
Branko R
BR
Brkić
Marjana P
MP
Nestorović
Natasa M
NM
Sekulić
Milka I
MI
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D048429:Cell Size / Q000187:drug effects; D052680:Corticotrophs / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D019833:Genistein / Q000494:pharmacology*; D007150:Immunohistochemistry; D008297:Male; D009919:Orchiectomy; D009929:Organ Size; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D047428:Protein Kinase Inhibitors; D000324:Adrenocorticotropic Hormone; D019833:Genistein