Abdominal visceral adiposity in the first trimester predicts glucose intolerance in later pregnancy.
OBJECTIVE
To assess whether abdominal adiposity in early pregnancy is associated with a higher risk of glucose intolerance at a later gestational stage.


METHODS
Subcutaneous and visceral fat was measured with ultrasonography at approximately 12 weeks' gestation. A 50-g glucose challenge test (GCT) was performed between 24 and 28 weeks' gestation. The risk of having a positive GCT (>or=7.8 mmol/l) was determined in association with subcutaneous and visceral adipose tissue depths above their respective upper-quartile values relative to their bottom three quartile values.


RESULTS
Sixty-two women underwent GCTs. A visceral adipose tissue depth above the upper quartile value was significantly associated with a positive GCT in later pregnancy (adjusted odds ratio 16.9 [95% CI 1.5-194.6]). No associations were seen for subcutaneous adipose tissue.


CONCLUSIONS
Measurement of visceral adipose tissue depth in early pregnancy may be associated with glucose intolerance later in pregnancy.
Martin
Aisling Mary
AM
Department of Obstetrics and Gynecology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Berger
Howard
H
Nisenbaum
Rosane
R
Lausman
Andrea Y
AY
MacGarvie
Sharon
S
Crerar
Carrie
C
Ray
Joel G
JG
D000005:Abdomen / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology*; D006801:Humans; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D018570:Risk Assessment; D016216:Ultrasonography, Prenatal; D014781:Viscera / Q000033:anatomy & histology*