title: Bone healing of severe acetabular defects after revision arthroplasty.
abstract: OBJECTIVE
  Healing of acetabular bone grafts may be difficult to assess in conventional radiographs. We used PET to analyze healing of morselized bone allografts, impacted in large osteolytic acetabular defects at revision arthroplasty.
  
  
  METHODS
  7 cases had a cup revision because of loosening, with repair of a segmental defect using a perforated, wide and thin plate. The osteolytic acetabulum was impacted with morselized bone allograft before cementing a polyethylene cup. [(18)F]-fluoride PET scans were used to monitor bone healing inside the graft bed 1 week, 4 weeks, and 12 months after surgery. The contralateral pelvic bone above the acetabulum was used as reference. A second group of 4 cases was analyzed for bone-forming activity in the state of mechanical loosening of an acetabular component of a THA.
  
  
  RESULTS
  Preoperatively, the uptake was raised by 64% compared to the reference. 1 week after surgery it was increased by 77% in segmental regions, while the uptake was at the reference level in cavitary regions. After 4 months the uptake was increased by 91% in cavitary regions and by 117% in segmental regions. 1 year after surgery, the increase in uptake was 20% in both regions. All implants were stable on radiographs.
  
  
  CONCLUSIONS
  We found PET to be a sensitive and useful method for evaluation of the spatial and temporal development of bone formation.
authors.affiliation: Department of Orthopedics, Gavle Hospital Center for Research and Development Uppsala University/Gavleborg County Council, Uppsala, Sweden.
authors.forename: Gösta
authors.initials: G
authors.lastname: Ullmark
authors.forename: Jens
authors.initials: J
authors.lastname: Sörensen
authors.forename: Olle
authors.initials: O
authors.lastname: Nilsson
mesh_terms: D000077:Acetabulum / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000209:etiology; D049268:Positron-Emission Tomography; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation