Complement and natural antibody are required in the long-term memory response to influenza virus.
Complement, complement receptors and natural antibody (IgM) are important factors in the immune response against pathogens. Previous studies have indicated a role for C3, the complement receptors CD35/CD21 (CR1/CR2), and IgM in the immune response to influenza virus. Nevertheless, their contribution to the long-term memory response to this pathogen remains unknown. To elucidate this role, we characterized the secondary response on mice deficient of CR1/CR2 (Cr2-/-), C3 (C3-/-), secreted IgM (micros-/-) and the double knockout C3-/-micros-/-. Overall, our results suggest that C3, IgM and CR1/CR2 play crucial roles in the maintenance of long-term memory to influenza virus, possibly through the development of memory B cells and long-term antibody secretion.
Fernandez Gonzalez
Santiago
S
Immune Disease Institute and Department of Pediatrics and Pathology, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA.
Jayasekera
Jerome Priyantha
JP
Carroll
Michael C
MC
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D003176:Complement C3 / Q000502:physiology*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000502:physiology*; D007156:Immunologic Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D009975:Orthomyxoviridae / Q000276:immunology*; D017463:Receptors, Complement 3b / Q000502:physiology*; D017464:Receptors, Complement 3d / Q000502:physiology*
D000914:Antibodies, Viral; D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D017463:Receptors, Complement 3b; D017464:Receptors, Complement 3d