title: Serum resistin and adiponectin levels in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  This study was performed to compare the serum levels of resistin and adiponectin in women with polycystic ovary syndrome (PCOS) and normal controls.
  
  
  METHODS
  Seventy-six patients (36 obese, 40 non-obese) with PCOS and 42 healthy subjects were included in the study. Serum levels of resistin, adiponectin, follicle-stimulating hormone, luteinising hormone, dehydroepiandrosterone sulfate (DHEA-S), 17-hydroxy progesterone, free testosterone, androstenedione, glucose, insulin and lipid parameters were measured. Insulin resistance and carbohydrate metabolism were evaluated by using the homeostasis model (HOMA) and the area under the insulin curve (AUCI).
  
  
  RESULTS
  Plasma resistin levels, HOMA-IR and AUCI were significantly higher and adiponectin level was lower in women with PCOS than those in healthy women. Plasma resistin levels were similar among obese and non-obese women with PCOS. No correlation was observed between resistin, body mass index (BMI), HOMA-IR, AUCI, insulin, lipid parameters and serum androgen levels. In obese PCOS patients, adiponectin levels were lower than in the lean PCOS patients. A negative correlation was observed among adiponectin, HOMA-IR, AUCI, BMI, testosterone, DHEAS, total-cholesterol, LDL-cholesterol and lipoprotein (a) levels.
  
  
  CONCLUSIONS
  These results suggest that the serum adiponectin level may be involved in the pathogenesis of PCOS. But resistin levels were independently associated with insulin resistance and BMI in PCOS patients. Nevertheless, wider-scale trials are required to be performed on this subject.
authors.affiliation: Faculty of Medicine, Department of Endocrinology and Metabolism, Kýrýkkale University, Kýrýkkale, Turkey. murartt@hotmail.com
authors.forename: Murat
authors.initials: M
authors.lastname: Yilmaz
authors.forename: Neslihan
authors.initials: N
authors.lastname: Bukan
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Demirci
authors.forename: Ciğdem
authors.initials: C
authors.lastname: Oztürk
authors.forename: Erdal
authors.initials: E
authors.lastname: Kan
authors.forename: Göksun
authors.initials: G
authors.lastname: Ayvaz
authors.forename: Metin
authors.initials: M
authors.lastname: Arslan
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D015992:Body Mass Index; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D009765:Obesity / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D052243:Resistin / Q000097:blood*; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D007328:Insulin; D008055:Lipids; C499624:RETN protein, human; D052243:Resistin