Design and development of dendrimer photosensitizer-incorporated polymeric micelles for enhanced photodynamic therapy.
Photodynamic therapy (PDT), which involves systemic administration of photosensitizers (PSs) followed by local photoillumination, is a promising method for the treatment of solid tumors and other diseases. Recently, considerable efforts have been devoted to the development of nanocarriers for the PS delivery with the aim of avoiding non-specific phototoxicity to normal tissues such as the skin. Here, we discuss the biological significance of the use of nanocarrier-encapsulated PSs in PDT. Also, we report our recent achievements on the development of dendrimer photosensitizer-loaded micelles as nanocarriers for PS delivery. We found that our nanocarriers greatly enhanced the PDT efficacy in vitro and in vivo, and also significantly reduced the skin phototoxicity. These results indicate the importance of a development strategy for nanocarriers and their great potential for clinical use. In addition, this review discusses the development of nanocarriers for emerging PDT-related technologies such as photodynamic diagnosis (PDD) and photochemical internalization (PCI).
Nishiyama
Nobuhiro
N
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Morimoto
Yuji
Y
Jang
Woo-Dong
WD
Kataoka
Kazunori
K
D000818:Animals; D050091:Dendrimers / Q000008:administration & dosage* / Q000138:chemical synthesis; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D006801:Humans; D008823:Micelles; D010778:Photochemotherapy / Q000379:methods* / Q000639:trends; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000138:chemical synthesis; D011108:Polymers / Q000008:administration & dosage* / Q000138:chemical synthesis
D050091:Dendrimers; D008823:Micelles; D017319:Photosensitizing Agents; D011108:Polymers