title: Impact of gender and age on in vivo virtual histology-intravascular ultrasound imaging plaque characterization (from the global Virtual Histology Intravascular Ultrasound [VH-IVUS] registry).
abstract: Virtual histology intravascular ultrasound (VH-IVUS) analyses were performed in the first 990 patients enrolled in the 3,000+ patient global VH-IVUS Registry to assess the impact of gender and age on in vivo VH-IVUS plaque characterization. The 990 patients were divided into 3 age group terciles (<58, 58 to 68, and >68 years) and again divided according to gender. In conclusion, (1) both women and men had an increase in plaque with increasing age; (2) at any age, men had more plaque than women; (3) percentages of dense calcium and necrotic core increased with increasing patient age in both men and women; and (4) gender differences were lowest in the oldest tercile (>68 years).
authors.affiliation: Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Qian
authors.forename: Akiko
authors.initials: A
authors.lastname: Maehara
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.forename: M Pauliina
authors.initials: MP
authors.lastname: Margolis
authors.forename: Amir
authors.initials: A
authors.lastname: Lerman
authors.forename: Jason
authors.initials: J
authors.lastname: Rogers
authors.forename: Shuel
authors.initials: S
authors.lastname: Banai
authors.forename: Samer
authors.initials: S
authors.lastname: Kazziha
authors.forename: Celia
authors.initials: C
authors.lastname: Castellanos
authors.forename: Lokesh
authors.initials: L
authors.lastname: Dani
authors.forename: Martin
authors.initials: M
authors.lastname: Fahy
authors.forename: Gregg W
authors.initials: GW
authors.lastname: Stone
authors.forename: Martin B
authors.initials: MB
authors.lastname: Leon
mesh_terms: D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D001707:Biopsy, Needle; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011336:Probability; D011379:Prognosis; D012042:Registries; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012737:Sex Factors; D016019:Survival Analysis; D018084:Ultrasonography, Interventional; D014584:User-Computer Interface