title: Adiposity in relation to colorectal adenomas and hyperplastic polyps in women.
abstract: OBJECTIVE
  To examine whether BMI is independently related to colorectal adenomas and hyperplastic polyps.
  
  
  METHODS
  We conducted a cross-sectional study among 1,420 asymptomatic women aged 40-79 years who had undergone complete colonoscopy. Logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals (CI) of adenomas and hyperplastic polyps.
  
  
  RESULTS
  We identified 953 women (67.1%) with no polyps, 292 (20.6%) with adenomas, and 175 (12.3%) with hyperplastic polyps. Among those with polyps, 75 women (5.3% of total women) were classified as having both adenomas and hyperplastic polyps. After adjusting for potential risk factors for colorectal cancer, BMI was related to increased risk of adenomas (OR comparing obese to normal weight women = 1.57; 95% CI = 1.07-2.29). Further, BMI was associated with enhanced risk of hyperplastic polyps (OR = 3.76; 95% CI = 2.35-6.01) and the combination of adenomas and hyperplastic polyps (OR = 2.84; 95% CI = 1.41-5.72).
  
  
  CONCLUSIONS
  Excess body mass is positively related to colorectal adenomas and hyperplastic polyps, particularly when both kinds of polyps are present in combination. Future studies should continue to delineate the possible differences in potential risk factors between colorectal adenomas and hyperplastic polyps. Such work should help further elucidate the possible causes of colorectal cancer.
authors.affiliation: The Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 6120 Executive Blvd., Bethesda, MD 20892, USA. michael.leitzmann@klinik.uni-regensburg.de
authors.forename: Michael F
authors.initials: MF
authors.lastname: Leitzmann
authors.forename: Andrew
authors.initials: A
authors.lastname: Flood
authors.forename: Leah M
authors.initials: LM
authors.lastname: Ferrucci
authors.forename: Philip
authors.initials: P
authors.lastname: Schoenfeld
authors.forename: Brooks
authors.initials: B
authors.lastname: Cash
authors.forename: Arthur
authors.initials: A
authors.lastname: Schatzkin
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Cross
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000209:etiology*; D050154:Adiposity / Q000502:physiology*; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000453:epidemiology / Q000209:etiology; D007417:Intestinal Polyps / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D016017:Odds Ratio; D012307:Risk Factors