title: ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype.
abstract: We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3'-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3'-UTR VNTR, respectively) of DAT1. In addition, a similar pattern of over-transmission of paternal risk haplotypes (constructed from the above alleles) was also observed. Some support is also derived from the two smaller samples although neither is independently significant. Although the mechanism driving the paternal over-transmission of the DAT risk alleles is not known, these finding provide further support for this phenomenon.
authors.affiliation: Neuropsychiatric Genetics Research Group, Discipline of Psychiatry, Trinity College Dublin, Dublin, Ireland. zhhawi@tcd.ie
authors.forename: Z
authors.initials: Z
authors.lastname: Hawi
authors.forename: L
authors.initials: L
authors.lastname: Kent
authors.forename: M
authors.initials: M
authors.lastname: Hill
authors.forename: R J L
authors.initials: RJ
authors.lastname: Anney
authors.forename: K J
authors.initials: KJ
authors.lastname: Brookes
authors.forename: E
authors.initials: E
authors.lastname: Barry
authors.forename: B
authors.initials: B
authors.lastname: Franke
authors.forename: T
authors.initials: T
authors.lastname: Banaschewski
authors.forename: J
authors.initials: J
authors.lastname: Buitelaar
authors.forename: R
authors.initials: R
authors.lastname: Ebstein
authors.forename: A
authors.initials: A
authors.lastname: Miranda
authors.forename: R D
authors.initials: RD
authors.lastname: Oades
authors.forename: H
authors.initials: H
authors.lastname: Roeyers
authors.forename: A
authors.initials: A
authors.lastname: Rothenberger
authors.forename: J
authors.initials: J
authors.lastname: Sergeant
authors.forename: E
authors.initials: E
authors.lastname: Sonuga-Barke
authors.forename: H-C
authors.initials: HC
authors.lastname: Steinhausen
authors.forename: S V
authors.initials: SV
authors.lastname: Faraone
authors.forename: P
authors.initials: P
authors.lastname: Asherson
authors.forename: M
authors.initials: M
authors.lastname: Gill
mesh_terms: D020413:3' Untranslated Regions; D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D018392:Genomic Imprinting; D006239:Haplotypes; D006801:Humans; D018598:Minisatellite Repeats
chemical_list: D020413:3' Untranslated Regions; D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human