title: Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials.
abstract: Long-term diabetes increases the likelihood of developing secondary damage to numerous systems, and these complications represent a substantial cause of morbidity and mortality. Establishing the causes of diabetes remains the key step towards eradicating the disease, but the prevention and amelioration of diabetic complications is equally important for the millions of individuals who already have the disease or are likely to develop it before prophylaxis or a cure become routinely available. In this Review, we focus on four common complications of diabetes, discuss the range of pathologies that are precipitated by hyperglycaemia and highlight emerging targets for therapeutic intervention.
authors.affiliation: Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA. ncalcutt@ucsd.edu
authors.forename: Nigel A
authors.initials: NA
authors.lastname: Calcutt
authors.forename: Mark E
authors.initials: ME
authors.lastname: Cooper
authors.forename: Tim S
authors.initials: TS
authors.lastname: Kern
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D048909:Diabetes Complications / Q000097:blood / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D004195:Disease Models, Animal; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage
chemical_list: D007004:Hypoglycemic Agents