title: [Relation between atherosclerotic calcifications detected in chest computed tomography and lung function].
abstract: OBJECTIVE
  A few recent epidemiological findings indicate a link between atherosclerosis and some lung functions. We studied further the relation between calcified chest atherosclerosis as seen in computed tomography (CT) and several lung functional parameters.
  
  
  METHODS
  Male construction workers originally screened for occupational lung cancer with CT had their chest atherosclerosis (aorta, the origins of its cervical branches, the coronary arteries and heart valves) visually classified. The relation between the atherosclerotic calcification scores and lung function (total lung capacity [TLC], forced expiratory volume in one second [FEV1%], forced vital capacity [FVC%], maximal expiratory flow when 50% of FVC remains to be exhaled, total and specific diffusing capacities; all above expressed as percent of predicted value, and the FEV1/FVC% ratio) were studied with the general linear model adjusted for smoking, exposure years for asbestos, and body mass index (n=432).
  
  
  RESULTS
  All lung functions except TLC showed significant negative associations with calcifications in aorta and in its branches. TLC showed such association only with atherosclerosis in the ascending aorta.
  
  
  CONCLUSIONS
  Aortic atherosclerosis seems to be related with poor lung function. This may be due to deteriorated bronchial circulation, but other mechanisms can also be involved. Lung function poorer than would be expected due to pulmonary reasons may indicate aortic atherosclerosis.
authors.affiliation: Salud y Capacidad de Trabajo, Instituto Finlandés de Salud Ocupacional, Helsinki, Finlandia. tapio.vehmas@ttl.fi
authors.forename: Tapio
authors.initials: T
authors.lastname: Vehmas
authors.forename: Asta
authors.initials: A
authors.lastname: Hiltunen
authors.forename: Päivi
authors.initials: P
authors.lastname: Leino-Arjas
authors.forename: Päivi
authors.initials: P
authors.lastname: Piirilä
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001018:Aortic Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D001195:Asbestosis / Q000000981:diagnostic imaging; D050197:Atherosclerosis / Q000150:complications / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000150:complications / Q000000981:diagnostic imaging*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging; D006349:Heart Valve Diseases / Q000150:complications / Q000000981:diagnostic imaging; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D011653:Pulmonary Diffusing Capacity; D012123:Pulmonary Ventilation; D012907:Smoking / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D014109:Total Lung Capacity