title: Electrodiagnosis of botulism and clinico-electrophysiological correlation.
abstract: OBJECTIVE
  An electrophysiological study can help to confirm the diagnosis of botulism. This study was aimed at validating a simple and reliable electrodiagnostic test and at correlating the findings with clinical severity.
  
  
  METHODS
  Pre- and post-exercise single supramaximal stimulations (SSSs) were performed in 63 patients with botulism. The sensitivity and specificity of amplitude of compound muscle action potential (CMAP) and percentage increment (PI) of SSS were determined. These two parameters were then correlated with respiratory failure. The relationship between the amplitude of CMAP and PI was also studied.
  
  
  RESULTS
  SSS with a PI of 25% showed a sensitivity of 95.2% and a specificity of 100% in association with botulism. The area under the receiver operating characteristic (ROC) curve of CMAP and PI was associated with the respiratory failure by 0.7 and 0.6, respectively. An inverse relationship between the amplitude of CMAP and PI was also demonstrated.
  
  
  CONCLUSIONS
  SSS is sensitive and specific in the diagnosis of botulism. There was some correlation of the findings with clinical severity. The inverse relationship between the amplitude of CMAP and PI reflects the pathophysiology of this disorder.
  
  
  CONCLUSIONS
  This study has validated SSS as being a simple and reliable electrodiagnostic test for botulism.
authors.affiliation: Department of Medicine, Nan Hospital, Nan, Thailand. rarwt@mahidol.ac.th
authors.forename: Rawiphan
authors.initials: R
authors.lastname: Witoonpanich
authors.forename: Ekawat
authors.initials: E
authors.lastname: Vichayanrat
authors.forename: Kanit
authors.initials: K
authors.lastname: Tantisiriwit
authors.forename: Sasivimol
authors.initials: S
authors.lastname: Rattanasiri
authors.forename: Atiporn
authors.initials: A
authors.lastname: Ingsathit
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001906:Botulism / Q000175:diagnosis* / Q000503:physiopathology*; D016022:Case-Control Studies; D004568:Electrodiagnosis / Q000379:methods*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012131:Respiratory Insufficiency / Q000503:physiopathology; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D055815:Young Adult