title: Implications of gain modulation in brainstem circuits: VOR control system.
abstract: Gain modulation is believed to be a common integration mechanism employed by neurons to combine information from various sources. Although gain fields have been shown to exist in some cortical and subcortical areas of the brain, their existence has not been explored in the brainstem. In the present modeling study, we develop a physiologically relevant simplified model for the angular vestibulo-ocular reflex (VOR) to show that gain modulation could also be the underlying mechanism that modifies VOR function with sensorimotor context (i.e. concurrent eye positions and stimulus intensity). The resulting nonlinear model is further extended to generate both slow and quick phases of the VOR. Through simulation of the hybrid nonlinear model we show that disconjugate eye movements during the VOR are an inevitable consequence of the existence of such gain fields in the bilateral VOR pathway. Finally, we will explore the properties of the predicted disconjugate component. We will demonstrate that the apparent phase characteristics of the disconjugate response vary with the concurrent conjugate component.
authors.affiliation: Biomedical Engineering Department, McGill University, Montreal, Quebec, Canada. elham.khojasteh@mcgill.ca
authors.forename: Elham
authors.initials: E
authors.lastname: Khojasteh
authors.forename: Henrietta L
authors.initials: HL
authors.lastname: Galiana
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000166:cytology* / Q000502:physiology*; D003198:Computer Simulation; D005133:Eye Movements / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D009039:Motion Perception / Q000502:physiology; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009760:Nystagmus, Physiologic / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D013997:Time Factors