[Conservative E(y)2/Sus1 protein interacts with the Su(Hw)-dependent insulators in Drosophila].
Insulators are regulatory elements having two properties. First, they are able to disturb the interaction between promoters and enhancers/silencers. Second, they are able to block distribution of the heterochromatin. The best-studied are the Su(Hw)-dependent insulators of Drosophila melanogaster, activity of which is determined by the Su(Hw) protein. In this study it was demonstrated that novel, evolutionary conservative transcription factor E(y)2/Sus1 interacted with the Su(Hw) zinc-finger domain and was present in the protein complex, associated with the Su(Hw)-dependent insulators.
Kurshakova
M M
MM
Kopytova
D V
DV
Nabirochkina
E N
EN
Soshnikova
N V
NV
Georgieva
S G
SG
Krasnov
A N
AN
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism*; D038101:Insulator Elements / Q000502:physiology*; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D006570:Heterochromatin; D046912:Multiprotein Complexes; D012097:Repressor Proteins; D014157:Transcription Factors; C423782:e(y)2 protein, Drosophila; C083738:su(Hw) protein, Drosophila