title: Brain pathways of verbal working memory: a lesion-function correlation study.
abstract: Working memory relies on information processing by several well-identified gray matter regions. However, the white matter regions and pathways involved in this cognitive process remain unknown. An attractive and underexplored approach to study white matter connectivity in cognitive functions is through the use of non-aprioristic models, which specifically search disrupted white matter pathways. For this purpose, we used voxel-based lesion-function mapping to correlate white matter lesions on the magnetic resonance images of 54 multiple sclerosis patients with their performance on a verbal working memory task. With this approach, we have identified critical white matter regions involved in verbal working memory in humans. They are located in the cingulum, parieto-frontal pathways and thalamo-cortical projections, with a left-sided predominance, as well as the right cerebellar white matter. Our study provides direct evidence on the white matter pathways subserving verbal working memory in the human brain.
authors.affiliation: Department of Neurology and Neurosurgery, University of Navarra, Pamplona, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Sepulcre
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Masdeu
authors.forename: Maria A
authors.initials: MA
authors.lastname: Pastor
authors.forename: Joaquín
authors.initials: J
authors.lastname: Goñi
authors.forename: Carla
authors.initials: C
authors.lastname: Barbosa
authors.forename: Bartolomé
authors.initials: B
authors.lastname: Bejarano
authors.forename: Pablo
authors.initials: P
authors.lastname: Villoslada
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D011939:Mental Recall; D009103:Multiple Sclerosis / Q000503:physiopathology*; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D009434:Neural Pathways / Q000503:physiopathology*; D013223:Statistics as Topic; D014705:Verbal Behavior