title: Gut microbiome modulates the toxicity of hydrazine: a metabonomic study.
abstract: The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.
authors.affiliation: Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus, London SW72AZ, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Swann
authors.forename: Yulan
authors.initials: Y
authors.lastname: Wang
authors.forename: Leticia
authors.initials: L
authors.lastname: Abecia
authors.forename: Adele
authors.initials: A
authors.lastname: Costabile
authors.forename: Kieran
authors.initials: K
authors.lastname: Tuohy
authors.forename: Glenn
authors.initials: G
authors.lastname: Gibson
authors.forename: David
authors.initials: D
authors.lastname: Roberts
authors.forename: James
authors.initials: J
authors.lastname: Sidaway
authors.forename: Huw
authors.initials: H
authors.lastname: Jones
authors.forename: Ian D
authors.initials: ID
authors.lastname: Wilson
authors.forename: Jeremy
authors.initials: J
authors.lastname: Nicholson
authors.forename: Elaine
authors.initials: E
authors.lastname: Holmes
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology*; D006834:Hydrazines / Q000378:metabolism / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D055432:Metabolomics / Q000379:methods; D054892:Metagenome; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002273:Carcinogens; D006834:Hydrazines; C029424:hydrazine