Use of 5,5-(dimethyl)-i-Pr-PHOX as a practical equivalent to t-Bu-PHOX in asymmetric catalysis.
The use of 5,5-(dimethyl)-i-Pr-PHOX as a practical equivalent of t-Bu-PHOX in asymmetric catalysis is reported. This new member of the phosphinooxazoline (PHOX) ligand family behaves similarly in terms of stereoinduction to t-Bu-PHOX with the key advantage of being readily accessible as both enantiomers starting from either (S)- or (R)-valine.
Bélanger
Etienne
E
Organic and Medicinal Chemistry, Département de chimie, Université Laval, Québec, QC, Canada G1V 0A6.
Pouliot
Marie-France
MF
Paquin
Jean-François
JF
D002384:Catalysis; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
C541181:5,5-(dimethyl)-i-Pr-PHOX; D010080:Oxazoles