title: Calcareous degeneration of host-donor interface after descemet membrane stripping with automated endothelial keratoplasty.
abstract: OBJECTIVE
  To report a case of host-donor interface calcification after Descemet membrane stripping with automated endothelial keratoplasty (DSAEK).
  
  
  METHODS
  Review of the patient's clinical records and histopathologic examination of the donor corneal lamella from repeat DSAEK performed subsequent to the original DSAEK.
  
  
  RESULTS
  Review of the clinical record of the patient revealed an ocular history of Fuchs dystrophy and pseudophakic bullous keratoplasty that was treated with DSAEK. She later developed corneal edema and a partially detached donor lamella and underwent repeat DSAEK. Histopathologic and transmission electron microscopic evaluations of the corneal lamella revealed calcium deposits in the host-donor interface.
  
  
  CONCLUSIONS
  Calcareous degeneration of the host-donor interface after DSAEK is reported as a novel postoperative complication of DSAEK. Calcium deposits in the host-donor interface after DSAEK should be considered in the differential diagnosis of interface opacity after this procedure, particularly in patients with predisposing systemic or local risk factors such as retained phosphate-containing viscoelastic material, excessive postoperative inflammation, or use of phosphate-buffered, postoperative topical medications.
authors.affiliation: Eye Pathology Laboratory, Wilmer Eye Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
authors.forename: Katayoon B
authors.initials: KB
authors.lastname: Ebrahimi
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Oster
authors.forename: W Richard
authors.initials: WR
authors.lastname: Green
authors.forename: Rhonda
authors.initials: R
authors.lastname: Grebe
authors.forename: Oliver D
authors.initials: OD
authors.lastname: Schein
authors.forename: Albert S
authors.initials: AS
authors.lastname: Jun
mesh_terms: D002114:Calcinosis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003316:Corneal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D003319:Corneal Stroma / Q000378:metabolism / Q000648:ultrastructure; D016039:Corneal Transplantation; D003460:Crystallization; D003886:Descemet Membrane / Q000601:surgery*; D004728:Endothelium, Corneal / Q000637:transplantation*; D005260:Female; D005642:Fuchs' Endothelial Dystrophy / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications; D012086:Reoperation; D014019:Tissue Donors; D014792:Visual Acuity
chemical_list: D002118:Calcium