Development of PMMA membranes functionalized with hydroxypropyl-beta-cyclodextrins for controlled drug delivery using a supercritical CO(2)-assisted technology.
Cyclodextrin-containing polymers have proved themselves to be useful for controlled release. Herein we describe the preparation of membranes of poly(methylmethacrylate) (PMMA) containing hydroxypropyl-beta-cyclodextrins (HP-beta-CDs) using a supercritical CO(2)-assisted phase inversion method, for potential application as drug delivery devices. Results are reported on the membrane preparation, physical properties, and drug elution profile of a model drug. The polymeric membranes were obtained with HP-beta-CD contents ranging from 0 to 33.4 wt%, by changing the composition of the casting solution, and were further impregnated with ibuprofen using supercritical carbon dioxide (scCO(2)) in batch mode. The influence of the membrane functionalization in the controlled release of ibuprofen was studied by performing in vitro experiments in buffer solution pH at 7.4. The release of the anti-inflammatory drug could be tuned by varying the cyclodextrin content on the membranes.
Temtem
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REQUIMTE/CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal.
Pompeu
D
D
Jaraquemada
G
G
Cabrita
E J
EJ
Casimiro
T
T
Aguiar-Ricardo
A
A
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002245:Carbon Dioxide / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D055772:Green Chemistry Technology; D007052:Ibuprofen / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D044367:Phase Transition; D019904:Polymethyl Methacrylate / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D047392:beta-Cyclodextrins; D002245:Carbon Dioxide; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D019904:Polymethyl Methacrylate; D007052:Ibuprofen