title: Databases of protein-protein interactions and their use in drug discovery.
abstract: Proteins rarely act alone. With the development of experimental technologies, researchers have started to map the interactions of proteins in different organisms. The data gathered constitute potential frameworks for system-based drug discovery. The possibility of targeting protein-protein interactions with specific drugs raises expectations of huge impact in the therapeutics field, despite the large quantity of research still necessary to delineate the complete interactome of a single cell. This review summarizes some concepts relating to protein-protein interfaces in relation to drug discovery, and discusses studies aiming to develop protein-protein interaction modulators through the combination of in silico and in vitro screening experiments.
authors.affiliation: Structural Computational Biology Group, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
authors.forename: Gloria
authors.initials: G
authors.lastname: Fuentes
authors.forename: Julen
authors.initials: J
authors.lastname: Oyarzabal
authors.forename: Ana M
authors.initials: AM
authors.lastname: Rojas
mesh_terms: D019992:Databases as Topic; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D008958:Models, Molecular; D054730:Protein Interaction Domains and Motifs / Q000187:drug effects*; D025941:Protein Interaction Mapping / Q000379:methods*; D054852:Small Molecule Libraries
chemical_list: D054852:Small Molecule Libraries