Severe bone demineralisation is associated with higher mortality in children with cystic fibrosis.
Decreased bone mineral density (BMD) is an emerging problem for clinicians who care for children with Cystic fibrosis (CF). The aim of this study was to determine prevalence and assess risk factors for reduced BMD in our adolescent population with CF. All bone densitometry scans (n=99) performed on children (n=79) with a mean age 13.6 (10-19.2) years over a 7 year period (2000-2007) were reviewed. Patient records were reviewed for correlating clinical data. Low BMD is frequently present in adults and children with variable reports (36-66%). In our study, BMD expressed as z score of L2-L4 spine was reduced in a total of 50% children with a preponderance of males. Bone demineralization was strongly associated with increasing age (p=0.03), diminished lung function (p=0.027), reduced body mass index (p=0.001) and treatment with oral corticosteroids (p=0.02).
O'Reilly
R
R
Cystic Fibrosis Department, National Children's Hospital, Tallaght, Dublin. ruthieor@hotmail.com
Fitzpatrick
P
P
Leen
G
G
Elnazir
B
B
Greally
P
P
D015502:Absorptiometry, Photon; D000293:Adolescent; D000305:Adrenal Cortex Hormones; D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D018488:Bone Demineralization, Pathologic / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D015519:Bone Density; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D009154:Mutation; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
D000305:Adrenal Cortex Hormones