Malignant granular cell tumor of the ulnar nerve with novel cytogenetic and molecular genetic findings.
We report an unusual case of ulnar nerve-based malignant granular cell tumor characterized by gains of chromosome 10 and loss of P16 detected by conventional karyotyping and by fluorescence in situ hybridization, respectively, in a 74-year-old male. To our knowledge, these findings have never been reported previously in malignant granular cell tumors.
Papachristou
Dionysios J
DJ
Department of Pathology, Presbyterian-Shadyside Hospital, University of Pittsburgh Medical Center, Room WG2.9, Pittsburgh, PA 15232, USA.
Palekar
Alka
A
Surti
Urvashi
U
Cieply
Kathleen
K
McGough
Richard L
RL
Rao
Uma N M
UN
D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D020732:Cytogenetic Analysis; D016586:Granular Cell Tumor / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007265:Inhibins / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D011123:Polyploidy; D014314:Trisomy / Q000235:genetics; D014459:Ulnar Nerve / Q000473:pathology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D007265:Inhibins; D051059:PTEN Phosphohydrolase; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C494929:PTEN protein, human