Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease.
OBJECTIVE
The aim of this study was to assess the test-retest variability of [11C]PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.


METHODS
[11C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.


RESULTS
Test-retest variability was best ( approximately 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values ( approximately 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.


CONCLUSIONS
Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [11C]PIB PET studies.
Tolboom
Nelleke
N
Departments of Nuclear Medicine & PET Research, VU University Medical Centre, Amsterdam, The Netherlands. n.tolboom@vumc.nl
Yaqub
Maqsood
M
Boellaard
Ronald
R
Luurtsema
Gert
G
Windhorst
Albert D
AD
Scheltens
Philip
P
Lammertsma
Adriaan A
AA
van Berckel
Bart N M
BN
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D000814:Aniline Compounds; D052160:Benzothiazoles; D002250:Carbon Radioisotopes; D016022:Case-Control Studies; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods* / Q000706:statistics & numerical data; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D013844:Thiazoles