title: Determination of proton relaxivities of Mn(II), Cu(II) and Cr(III) added to solutions of serum proteins.
abstract: Relaxometric studies are still of scientific interest due to their use in medicine and biology. In this study, proton T(1) and T(2) relaxivities of Mn(II), Cu(II) and Cr(III) in water were determined in the presence and absence of various proteins (albumin, alpha-globulin, gamma-globulin, lysozyme, fibrinogen). The 1/T(1) and 1/T(2) in all solutions are linearly proportional to the concentration of the paramagnetic ions. Mn(II) has the great influence to alter relaxations in all protein solutions, while Cu(II) and Cr(III) have a poor influence on the relaxations. In addition, Mn(II) and Cu(II) are bound to each protein, but Cr(III) is not bound to any protein.
authors.affiliation: Department of Physics, University of Dicle, 21280 Diyarbakir, Turkey. zkoylu@dicle.edu.tr
authors.forename: Mehmet Zafer
authors.initials: MZ
authors.lastname: Köylü
authors.forename: Sezai
authors.initials: S
authors.lastname: Asubay
authors.forename: Ali
authors.initials: A
authors.lastname: Yilmaz
mesh_terms: D000418:Albumins / Q000737:chemistry; D000510:Alpha-Globulins / Q000737:chemistry; D001798:Blood Proteins / Q000737:chemistry*; D002857:Chromium / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D005340:Fibrinogen / Q000737:chemistry; D008345:Manganese / Q000737:chemistry*; D009113:Muramidase / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D011485:Protein Binding; D011522:Protons; D005719:gamma-Globulins / Q000737:chemistry
chemical_list: D000418:Albumins; D000510:Alpha-Globulins; D001798:Blood Proteins; D011522:Protons; D005719:gamma-Globulins; D002857:Chromium; D008345:Manganese; D003300:Copper; D005340:Fibrinogen; D009113:Muramidase