Effect of perospirone on P300 electrophysiological activity and social cognition in schizophrenia: a three-dimensional analysis with sloreta.
The purpose of this study was to determine if perospirone, a second generation antipsychotic drug and partial agonist at serotonin-5-HT(1A) receptors, enhances electrophysiological activity, such as event-related potentials (ERPs), in frontal brain regions, as well as cognitive function in subjects with schizophrenia. P300 current source images were obtained by means of standardized low resolution brain electromagnetic tomography (sLORETA) before and after treatment with perospirone for 6 months. Perospirone significantly increased P300 current source density in the left superior frontal gyrus, and improved positive symptoms and performance on the script tasks, a measure of verbal social cognition, while verbal learning memory tended to be improved. There was a significant correlation between the changes in P300 amplitude on the left frontal lead and those in social cognition. These results suggest the changes in three-dimensional distribution of cortical activity, as demonstrated by sLORETA, may mediate some of the actions of antipsychotic drugs. The distinct cognition-enhancing profile of perospirone in patients with schizophrenia may be related to its actions on 5-HT(1A) receptors.
Sumiyoshi
Tomiki
T
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan. tomikisumiyoshi840@hotmail.com <tomikisumiyoshi840@hotmail.com>
Higuchi
Yuko
Y
Itoh
Toru
T
Matsui
Mie
M
Arai
Hirofumi
H
Suzuki
Michio
M
Kurachi
Masayoshi
M
Sumiyoshi
Chika
C
Kawasaki
Yasuhiro
Y
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001931:Brain Mapping / Q000379:methods; D003071:Cognition / Q000187:drug effects*; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000503:physiopathology; D007839:Functional Laterality / Q000187:drug effects; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods; D054833:Isoindoles / Q000008:administration & dosage / Q000627:therapeutic use*; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D009483:Neuropsychological Tests; D010045:Outpatients; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012938:Social Perception; D013844:Thiazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D014706:Verbal Learning / Q000187:drug effects; D055815:Young Adult
D014150:Antipsychotic Agents; D054833:Isoindoles; D013844:Thiazoles; C065533:perospirone