Minireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis.
Glucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central GLP-1 reduces food intake and body weight. However, current research indicates that in fact, GLP-1 in each location plays a role in these functions. This review summarizes the evidence for involvement of peripheral and brain GLP-1 in food intake regulation and glucose homeostasis and proposes a model for the coordinated actions of GLP-1 at multiple sites.
Williams
Diana L
DL
Department of Psychology, 1107 West Call Street, Florida State University, Tallahassee, Florida 32306-4301, USA. williams@psy.fsu.edu
D001786:Blood Glucose / Q000378:metabolism*; D004435:Eating; D052216:Glucagon-Like Peptide 1 / Q000502:physiology*; D000067757:Glucagon-Like Peptide-1 Receptor; D006706:Homeostasis / Q000502:physiology; D008954:Models, Biological; D018027:Receptors, Glucagon / Q000502:physiology
D001786:Blood Glucose; D000067757:Glucagon-Like Peptide-1 Receptor; D018027:Receptors, Glucagon; D052216:Glucagon-Like Peptide 1