Autophagy in ischemic preconditioning and hibernating myocardium.
Autophagy is a major protective mechanism and has been identified in response to hypoxia and more recently, myocardial ischemia, but it is not known whether it is involved in mediating ischemic preconditioning, the most powerful intervention known to protect myocardium against lethal ischemic injury. We examined autophagy in several models of preconditioning induced by six repetitive episodes of ischemia every 12 hours versus classical first or second-window preconditioning in swine. The results indicated that autophagy is an important mechanism mediating cardioprotection following repetitive episodes of coronary stenosis or coronary occlusion, but less for traditional first or second window preconditioning.
Yan
Lin
L
Cardiovascular Research Institute, Department of Cell Biology & Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.
Sadoshima
Junichi
J
Vatner
Dorothy E
DE
Vatner
Stephen F
SF
D000818:Animals; D001343:Autophagy; D002316:Cardiotonic Agents / Q000378:metabolism; D000860:Hypoxia / Q000473:pathology; D019157:Ischemic Preconditioning, Myocardial; D008136:Longevity; D015428:Myocardial Reperfusion Injury / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D034421:Sus scrofa
D002316:Cardiotonic Agents