Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis.
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Umbilical cord derived mesenchymal stem cells are immunosuppressive. We transplanted mesenchymal stem cells in a patient with refractory progressive MS, and the disease course was stabilized after the transplantation. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
Liang
J
J
Department of Immunology and Rheumatology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, P. R. China.
Zhang
H
H
Hua
B
B
Wang
H
H
Wang
J
J
Han
Z
Z
Sun
L
L
D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008279:Magnetic Resonance Imaging; D045164:Mesenchymal Stem Cell Transplantation; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D013116:Spinal Cord / Q000473:pathology; D014184:Transplantation, Homologous