title: Evolution of protein modularity.
abstract: Proteins in their evolution appear to follow several discrete stages, which is reflected in their modular organization. The sequences of the protein modules are highly variable while their functions and structures are rather conserved. The relatedness of the variable sequences is well represented by the networks in natural protein sequence space that also suggests evolutionary connections.
authors.affiliation: Genome Diversity Center, Institute of Evolution, University of Haifa, Haifa 31905, Israel. trifonov@research.haifa.ac.il
authors.forename: Edward N
authors.initials: EN
authors.lastname: Trifonov
authors.forename: Zakharia M
authors.initials: ZM
authors.lastname: Frenkel
mesh_terms: D000595:Amino Acid Sequence; D019143:Evolution, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: D011506:Proteins