The mammalian family of sterile 20p-like protein kinases.
Twenty-eight kinases found in mammalian genomes share similarity to the budding yeast kinase Ste20p. This review article examines the biological function of these mammalian Ste20 kinases. Some of them have conserved the Ste20p function of transducing extracellular signals to mitogen-activated kinases. Others affect ion transport, cell cycle, cytoskeleton organization, and program cell death. A number of molecular details involved in the activation of the kinases are discussed including autophosphorylation, substrate recognition, autoinhibition, dimerization, and substrate binding.
Delpire
Eric
E
Department of Anesthesiology, Vanderbilt University Medical Center, T-4202 MCN 1161 21st Avenue South, Nashville, TN 37232-2520, USA. eric.delpire@vanderbilt.edu
D000818:Animals; D017124:Conserved Sequence / Q000502:physiology; D004789:Enzyme Activation / Q000502:physiology; D030342:Genetic Diseases, Inborn / Q000235:genetics; D000081410:Germinal Center Kinases; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000502:physiology; D020930:MAP Kinase Kinase Kinases; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000502:physiology*; D017434:Protein Structure, Tertiary / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000502:physiology; D054462:p21-Activated Kinases / Q000737:chemistry / Q000502:physiology*
D000081410:Germinal Center Kinases; D047908:Intracellular Signaling Peptides and Proteins; D029701:Saccharomyces cerevisiae Proteins; D017346:Protein Serine-Threonine Kinases; D054462:p21-Activated Kinases; D020930:MAP Kinase Kinase Kinases; C078754:STE20 protein, S cerevisiae