title: Crown-capped imidacloprid: a novel design and insecticidal activity.
abstract: Imidacloprid (IMI) derivatives conjugated with benzo-15-crown-5 and benzo-18-crown-6 structures, applied for the first time to explore novel insecticidal molecule, elicited strong excitatory toxic signs to the house flies and stunningly exhibited three to five times higher insecticidal activity than that of the parent IMI, yet the two benzo-crown structures themselves had no effect.
authors.affiliation: Department of Chemistry, Faculty of Education, Gifu University, Gifu, Japan. kagabus@gifu-u.ac.jp
authors.forename: Shinzo
authors.initials: S
authors.lastname: Kagabu
authors.forename: Masaru
authors.initials: M
authors.lastname: Takagi
authors.forename: Ikuya
authors.initials: I
authors.lastname: Ohno
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Mikawa
authors.forename: Toru
authors.initials: T
authors.lastname: Miyamoto
mesh_terms: D000818:Animals; D043844:Crown Ethers / Q000737:chemistry; D015195:Drug Design; D005260:Female; D006793:Houseflies / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D043844:Crown Ethers; D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; C042148:15-crown-5; C082359:imidacloprid; C015762:18-crown-6