Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population.
Thromboxane A2 (TBXA2) is a potent vasoconstrictor in cerebral circulation and is a known contributor to the pathogenesis of cerebral infarction. Thromboxane A2 synthase 1 (TBXAS1) and thromboxane A2 receptors (TBXA2R) are key components in TBXA2 function. We examined whether genetic variants in TBXA2R and TBXAS1 are risk factors for cerebral infarction by genotyping 453 Korean patients with noncardiogenic cerebral infarction and 260 controls. A few, specific polymorphisms in the TBXA2R (-3372G>C, +4710T>C and 4839T>C) and TBXAS1 (+16184G>T, +141931A>T and +177729G>A) genes were chosen and investigated. Logistic regression showed the frequencies of TBXAS1+16184G>T and TBXAS1- ht3 were significantly more frequent in cerebral infarction (P=0.002, OR=2.75 and P=0.01, OR=1.57, respectively), specifically in small-artery occlusion (SAO) type of cerebral infarction (P=0.0003 and 0.005, respectively). These results suggest specific TBXAS1 gene polymorphisms may be a useful marker for development of cerebral infarction, especially SAO type in Korean population.
Park
Sun Ah
SA
Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon 420-020, Korea.
Park
Byung Lae
BL
Park
Jeong Ho
JH
Lee
Tae Kyeong
TK
Sung
Ki Bum
KB
Lee
You Kyoung
YK
Chang
Hun Soo
HS
Park
Choon-Sik
CS
Shin
Hyoung Doo
HD
D000368:Aged; D044466:Asian People / Q000235:genetics; D002544:Cerebral Infarction / Q000235:genetics* / Q000473:pathology; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000235:genetics*; D013930:Thromboxane-A Synthase / Q000235:genetics*
D044244:Receptors, Thromboxane A2, Prostaglandin H2; D013930:Thromboxane-A Synthase