The use of bone morphogenetic protein in lumbar spine surgery.
Creating a solid lumbar spinal fusion remains a challenge. Despite advances in fixation, a pseudarthrosis still may occur. Recently, attention has focused on creating a more biologically favorable environment to enhance fusion rate. Bone morphogenetic proteins (BMPs) are a group of secreted growth factors that belong to the transforming growth factor-beta superfamily. Two recombinant BMP proteins, rhBMP-2 and rhBMP-7 (OP-1), have been used successfully in preclinical and clinical trials and are commercially available for clinical applications.
Rihn
Jeffrey A
JA
Department of Orthopedic Surgery, Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Gates
Charley
C
Glassman
Steven D
SD
Phillips
Frank M
FM
Schwender
James D
JD
Albert
Todd J
TJ
D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use*; D055419:Bone Morphogenetic Protein 7 / Q000627:therapeutic use*; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology / Q000601:surgery*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013123:Spinal Fusion / Q000379:methods*
D055396:Bone Morphogenetic Protein 2; D055419:Bone Morphogenetic Protein 7; D011994:Recombinant Proteins