The first magnetic nanoparticle-supported chiral DMAP analogue: highly enantioselective acylation and excellent recyclability.
Recyclable organocatalysts: The first chiral DMAP analogue immobilized on magnetic nanoparticles is a highly active catalyst that is capable of the acylation of racemic sec-alcohols under convenient, process-scale friendly conditions (room temperature, 5 mol % loading, with acetic anhydride as the acylating agent) with excellent enantiodiscrimination. The catalyst is easily recovered and possesses unprecedented recyclability-in this study it was demonstrated to retain excellent activity and selectivity over 32 iterative cycles.
Gleeson
Oliver
O
Centre for Synthesis and Chemical Biology, School of Chemistry, The University of Dublin, Trinity College, Dublin 2, Ireland.
Tekoriute
Renata
R
Gun'ko
Yurii K
YK
Connon
Stephen J
SJ