title: [Preparation of nanostructured lipid carriers loaded with supercritical carbon dioxide fluid extraction of Xionggui powder].
abstract: OBJECTIVE
  To study the preparation ofnanostructured lipid carriers loaded with supercritical carbon dioxide fluid extraction of Xionggui powder.
  
  
  METHODS
  Prepared nanostructured lipid carriers (NLC) loaded with supercritical carbon dioxide fluid extraction of Xionggui powder (XG-CO2-SFE) with a microemulsion ultrasonication method , established the best prescription of XG-CO2-SFE-NLC by orthogonal design methods with entrapment efficiency of nanoparticles as index, and investigated their physicochemical characterizations.
  
  
  RESULTS
  The best prescription was m(phospholipid) : m(S-40) : m(lipid carriers) = 5 : 2 : 1, the entrapment efficiency of nanopartices was 86.8%, results revealed that nanoparticles were sphere like with the mean size of 92.6 nm and the mean zeta potential was -20.68 mV.
  
  
  CONCLUSIONS
  The prep aration method of the XG-CO2-SFE-NLC is appropriate.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhang
authors.forename: Qingran
authors.initials: Q
authors.lastname: Feng
authors.forename: Rixian
authors.initials: R
authors.lastname: Jin
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry*; D025924:Chromatography, Supercritical Fluid; D004337:Drug Carriers / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification*; D004655:Emulsions; D016014:Linear Models; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D011208:Powders
chemical_list: D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D008055:Lipids; D011208:Powders; C540808:xionggui; D002245:Carbon Dioxide