Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development.
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a major worldwide health problem that causes more than 2 million deaths annually. In addition, an estimated 2 billion people are latently infected with M. tuberculosis. The bacterium is one of the oldest human pathogens and has evolved complex strategies for survival. Therefore, to be successful in the high endemic regions, any future TB vaccine strategy will have to be tailored in accordance with the resulting complexity of the TB infection and anti-mycobacterial immune response. In this review, we will discuss what is presently known about the interaction of M. tuberculosis with the immune system, and how this knowledge is used in new and more advanced vaccine strategies.
Dietrich
Jes
J
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark. JDI@ssi.dk
Doherty
T Mark
TM
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D017209:Apoptosis; D001500:BCG Vaccine / Q000276:immunology; D017322:Clinical Trials, Phase II as Topic; D015195:Drug Design; D014943:Global Health; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology; D007378:Interleukins / Q000502:physiology; D008262:Macrophage Activation; D008264:Macrophages / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D010587:Phagocytosis; D051192:Receptors, Pattern Recognition / Q000502:physiology; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D032581:Tuberculosis Vaccines / Q000276:immunology*; D022223:Vaccines, Subunit / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
D000995:Antitubercular Agents; D001500:BCG Vaccine; D007378:Interleukins; D051192:Receptors, Pattern Recognition; D032581:Tuberculosis Vaccines; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic; D007371:Interferon-gamma