title: [Birth defects in the Czech Republic in 1994--2007].
abstract: OBJECTIVE
  An analysis of occurrence of birth defects in the Czech Republic in 1994-2007. An assessment of total numbers and relative incidences of birth defects in births according to Tenth Revision of International Classification of Diseases (ICD-10).
  
  
  METHODS
  Retrospective epidemiological analysis of birth defects incidences from the Czech National Birth Defects Register database.
  
  
  METHODS
  Data from the National Birth Defects Register (Institute for Health Information and Statistics) in the Czech Republic in the 1994-2007 period were used. In this study, particular diagnoses--as they were registered in the National Register--were analyzed. The diagnoses in study were divided into following eleven birth defects groups according to ICD-10 classification: (Q00-Q07) nervous system, (Q10-Q18) eye, ear, face and neck, (Q20-Q28) circulatory system, (Q30-Q34) respiratory system, (Q35-Q37) cleft lip and cleft palate, (Q38-Q45) digestive system, (Q50-Q56) genital organs, (Q60-Q64) urinary system, (Q65-Q79) musculoskeletal system, (Q80-Q89) other defects and (Q90-Q99) chromosomal abnormalities, not elsewhere classified. Prenataly diagnosed cases are not included.
  
  
  RESULTS
  During 1994-2007 period, totally 1,353,040 children were born on the area of the Czech Republic, out of which 44,343 with a birth defect. The diagoses in study were divided into eleven groups according to ICD-10 classification. Further, particular diagnoses according to ICD-10 and their verbal descriptions are presented in tables. Each group is accompanied by data on its total number and a relative incidence (per 10,000 live births) with a 95% C.I.. A relative frequency of the birth defects groups in study (in % from the total number of birth defects) is as follows: (Q00-Q07) nervous system 2.10, (Q10-Q18) eye, ear, face and neck 4.76, (Q20-Q28) circulatory system 39.63, (Q30-Q34) respiratory system 1.03, (Q35-Q37) cleft lip and cleft palate 3.67, (Q38-Q45) digestive system 4.05, (Q50-Q56) genital organs 10.93, (Q60-Q64) urinary system 7.08, (Q65-Q79) musculoskeletal system 18.90, (Q80-Q89) other defects 5.55 and (Q90-Q99) chromosomal abnormalities 2.28.
  
  
  CONCLUSIONS
  The study gives updated results of incidences analysis of postnatally diagnosed birth defects (available on the date of August 31, 2008) in the Czech Republic in the 1994-2007 period. Data on birth defects were collected in the National Birth Defects Register (Institute for Health Information and Statistics). Birth defects registration is a compulsory process and is a part of the National Health Information System. The diagnoses in study were divided into eleven groups according to ICD-10 classification. Total numbers, relative incidences (per 10 000 live births, with a 95% C.I.) and relative frequencies of the birth defects groups are presented.
authors.affiliation: Oddelení lékarské genetiky, Fakultní Thomayerova nemocnice, Praha. registrvvv@vrozene-vady.cz
authors.forename: A
authors.initials: A
authors.lastname: Sípek
authors.forename: V
authors.initials: V
authors.lastname: Gregor
authors.forename: A
authors.initials: A
authors.lastname: Sípek
authors.forename: J
authors.initials: J
authors.lastname: Horácek
authors.forename: J
authors.initials: J
authors.lastname: Klaschka
authors.forename: J
authors.initials: J
authors.lastname: Skibová
authors.forename: P
authors.initials: P
authors.lastname: Langhammer
authors.forename: L
authors.initials: L
authors.lastname: Petrzílková
authors.forename: J
authors.initials: J
authors.lastname: Wiesnerová
mesh_terms: D000013:Congenital Abnormalities / Q000453:epidemiology*; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D011247:Pregnancy