NFATc2 Ser170 phosphorylation marks mitosis in development and ES cells.
NFATc2, also known as NFAT1 or NFATp, is a member of NFAT (calcineurin-dependent nuclear factor of activated T cells) family of transcription factors. As one of major targets for immunosuppressive drugs, NFATc2 has been studied largely in the context of T cell activation and proliferation. Recent evidence suggested that it has a broader role in both immune and non-immune systems in regulating cell cycle progression. Using a monoclonal antibody developed specifically against phospho-serine 170 (p-Ser170) of NFATc2, we show here that this phosphorylation marks the M phase of cell cycle both during embryonic development and in cultured fibroblast and ES cells.
Alev
Cantas
C
Wu
Yuping
Y
Nakazawa
Fumie
F
Asahara
Takayuki
T
Sheng
Guojun
G
D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002453:Cell Cycle; D002455:Cell Division; D053595:Embryonic Stem Cells / Q000502:physiology*; D006801:Humans; D008938:Mitosis; D008969:Molecular Sequence Data; D050778:NFATC Transcription Factors / Q000276:immunology / Q000378:metabolism*; D010766:Phosphorylation; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D050778:NFATC Transcription Factors