title: Prognostic factors in adult patients up to 60 years old with acute myeloid leukemia and translocations of chromosome band 11q23: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup.
abstract: OBJECTIVE
  To identify risk factors for induction success and overall survival (OS) and relapse-free survival (RFS) and to evaluate the impact of allogeneic stem-cell transplantation (alloSCT) in adult patients up to 60 years old with acute myeloid leukemia (AML) and reciprocal translocations involving chromosome band 11q23 [t(11q23)].
  
  
  METHODS
  An individual patient data-based meta-analysis was performed on 180 adult patients with AML and t(11q23). These patients were identified by cytogenetics and/or molecular techniques and treated within eight prospective multicenter trials of the German AML Intergroup. The median follow-up time was 53 months.
  
  
  RESULTS
  Complete remission rate was 71%. Favorable factors for induction success were the presence of a t(9;11), t(11q23) as a sole aberration, and de novo leukemia. OS rate at 4 years was 29%. Translocations other than t(9;11), platelets less than the median, secondary leukemia, and peripheral blasts greater than the median were adverse risk factors for OS. RFS rate at 4 years was 29%. The presence of a t(6;11) and peripheral blasts greater than the median had a negative impact on RFS. Three risk groups for OS and RFS could be defined by the combination of these factors with 4-year OS rates of 50%, 28%, and 5% and 4-year RFS rates of 37%, 26%, and 5%. An alloSCT from matched related or unrelated donors in first complete remission was beneficial, especially in t(6;11)-negative patients.
  
  
  CONCLUSIONS
  Risk stratification of AML patients with reciprocal translocations of chromosome band 11q23 is feasible based on the translocation partner and clinical parameters.
authors.affiliation: Department Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany. Krauter.Juergen@MH-Hannover.de
authors.forename: Jürgen
authors.initials: J
authors.lastname: Krauter
authors.forename: Katharina
authors.initials: K
authors.lastname: Wagner
authors.forename: Irina
authors.initials: I
authors.lastname: Schäfer
authors.forename: Rolf
authors.initials: R
authors.lastname: Marschalek
authors.forename: Claus
authors.initials: C
authors.lastname: Meyer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Heil
authors.forename: Markus
authors.initials: M
authors.lastname: Schaich
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ehninger
authors.forename: Dietger
authors.initials: D
authors.lastname: Niederwieser
authors.forename: Rainer
authors.initials: R
authors.lastname: Krahl
authors.forename: Thomas
authors.initials: T
authors.lastname: Büchner
authors.forename: Cristina
authors.initials: C
authors.lastname: Sauerland
authors.forename: Brigitte
authors.initials: B
authors.lastname: Schlegelberger
authors.forename: Konstanze
authors.initials: K
authors.lastname: Döhner
authors.forename: Hartmut
authors.initials: H
authors.lastname: Döhner
authors.forename: Richard F
authors.initials: RF
authors.lastname: Schlenk
authors.forename: Arnold
authors.initials: A
authors.lastname: Ganser
mesh_terms: D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality*; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D014178:Translocation, Genetic