title: Fluorinated carbohydrates as lectin ligands: versatile sensors in 19F-detected saturation transfer difference NMR spectroscopy.
abstract: As a novel approach for studying carbohydrate-lectin interactions spectroscopically, we combine the resolution and specificity of (19)F-detected NMR spectroscopy with the sensitivity of the saturation transfer difference (STD) technique. The resulting background-free (19)F-STD spectra open a promising perspective for broad application with medical relevance, for example, in drug discovery.
authors.affiliation: NMR facility, CiC bioGUNE, Parque Tecnológico de Bizkaia, Ed. 800, 48160 Derio, Spain.
authors.forename: Tammo
authors.initials: T
authors.lastname: Diercks
authors.forename: João P
authors.initials: JP
authors.lastname: Ribeiro
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Cañada
authors.forename: Sabine
authors.initials: S
authors.lastname: André
authors.forename: Jesús
authors.initials: J
authors.lastname: Jiménez-Barbero
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Gabius
mesh_terms: D000465:Algorithms; D002241:Carbohydrates / Q000737:chemistry*; D015195:Drug Design; D055808:Drug Discovery; D005461:Fluorine / Q000737:chemistry*; D006001:Glycoconjugates / Q000737:chemistry; D037102:Lectins / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*
chemical_list: D002241:Carbohydrates; D006001:Glycoconjugates; D037102:Lectins; D008024:Ligands; D005461:Fluorine