Neurodevelopment genes in lampreys reveal trends for forebrain evolution in craniates.
The forebrain is the brain region which has undergone the most dramatic changes through vertebrate evolution. Analyses conducted in lampreys are essential to gain insight into the broad ancestral characteristics of the forebrain at the dawn of vertebrates, and to understand the molecular basis for the diversifications that have taken place in cyclostomes and gnathostomes following their splitting. Here, we report the embryonic expression patterns of 43 lamprey genes, coding for transcription factors or signaling molecules known to be involved in cell proliferation, stemcellness, neurogenesis, patterning and regionalization in the developing forebrain. Systematic expression patterns comparisons with model organisms highlight conservations likely to reflect shared features present in the vertebrate ancestors. They also point to changes in signaling systems -pathways which control the growth and patterning of the neuroepithelium-, which may have been crucial in the evolution of forebrain anatomy at the origin of vertebrates.
Guérin
Adèle
A
Equipe Développement Evolution du Cerveau Antérieur, UPR2197-CNRS, Institut Alfred Fessard, Gif sur Yvette, France.
d'Aubenton-Carafa
Yves
Y
Marrakchi
Emna
E
Da Silva
Corinne
C
Wincker
Patrick
P
Mazan
Sylvie
S
Rétaux
Sylvie
S
D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning / Q000235:genetics; D049109:Cell Proliferation; D053595:Embryonic Stem Cells / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D007798:Lampreys / Q000196:embryology* / Q000235:genetics*; D008957:Models, Genetic; D055495:Neurogenesis / Q000235:genetics*; D010802:Phylogeny; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics; D016548:Prosencephalon / Q000196:embryology* / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics; D014714:Vertebrates / Q000196:embryology / Q000235:genetics
D018809:Proliferating Cell Nuclear Antigen