title: Papillary glioneuronal tumor-evidence of stem cell origin with biphenotypic differentiation.
abstract: Papillary glioneuronal tumors are newly recognized seizure producing tumors. We report two such cases with immunohistochemical characterization of glial and neuronal components and briefly review literature. Co-localization of glial and neuronal markers was demonstrable on confocal microscopy with expression of stem cell markers (Nestin and CD133) suggesting possible origin from neuroepithelial stem cell with biphenotypic differentiation.
authors.affiliation: Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
authors.forename: Aparna
authors.initials: A
authors.lastname: Govindan
authors.affiliation: Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India. amahadevan@nimhans.kar.nic.in.
authors.forename: A
authors.initials: A
authors.lastname: Mahadevan
authors.affiliation: Department of Neurosurgery, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
authors.forename: D I
authors.initials: DI
authors.lastname: Bhat
authors.affiliation: Department of Neurosurgery, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
authors.forename: A
authors.initials: A
authors.lastname: Arivazhagan
authors.affiliation: Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
authors.forename: Shrijeet
authors.initials: S
authors.lastname: Chakraborti
authors.affiliation: Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Suja
authors.affiliation: Department of Neurophysiology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
authors.forename: A A
authors.initials: AA
authors.lastname: Phalguni
authors.affiliation: Department of Neurosurgery, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
authors.forename: S
authors.initials: S
authors.lastname: Sampath
authors.affiliation: Department of Neurosurgery, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
authors.forename: B A
authors.initials: BA
authors.lastname: Chandramouli
authors.affiliation: Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Shankar
mesh_terms: D000071916:AC133 Antigen; D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D001932:Brain Neoplasms / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000473:pathology*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008297:Male; D008579:Meningioma; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009457:Neuroglia / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D010455:Peptides / Q000378:metabolism
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; D009419:Nerve Tissue Proteins; C000606023:PROM1 protein, human; D010455:Peptides