[Effects of calcium and vitamin D supplementation on bone specific alkaline during pregnancy lactation and infant].
OBJECTIVE
To investigate the effect of calcium and vitamin D supplementation during pregnancy, lactation and infants on bone development of infant.


METHODS
1176 health infants aged 42-365 days and their mothers were recruited as subjects at Pediatric Department in Beijing Obstetrics and Gynecology Hospital during November 2006 to January 2008. Retrospective questionnaire was asked about calcium and vitamin D supplementation during pregnancy, lactation and infant. Blood bone-specific alkaline (BAD) and fontanel anterior (FA) of infant were measured. Chi2 test and logistic regression were used to analyze the research data.


RESULTS
The chi2 test result showed that maternal supplementation with Ca and vitamin D during breastfeeding could decrease infant BAP significantly (P = 0.018), while supplementation during pregnancy could not (P = 0.154). The logistic regression result showed that infant supplementation with Ca and Vitamin D could decrease infant BAP significantly (P = 0.000), while infant feeding methods could not (P > 0.05). The FA size of infants aged < or =42 days had significant negative relationship with BAP (P = 0.017), and no relationship with Ca and vitmin D supplementation during pregnancy.


CONCLUSIONS
Supplementation with Ca and vitamin D of mother during lactation and infant could significantly decrease infant BAD. The FA size could not indicate the infant calcium status.
Wang
Jinping
J
Beijing Obstetrics and Gynecology Hospital of Capital Medical University, Beijing 100026, China. happy360360@126.com
Li
Haihong
H
He
Qing
Q
Ren
Chunghui
C
D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism*; D001846:Bone Development / Q000187:drug effects; D002118:Calcium / Q000008:administration & dosage*; D055762:Cranial Fontanelles / Q000033:anatomy & histology; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007223:Infant; D007774:Lactation; D016015:Logistic Models; D011247:Pregnancy; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000008:administration & dosage*
D014807:Vitamin D; D000469:Alkaline Phosphatase; D002118:Calcium