Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment.
A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (beta-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and beta-NGF may be useful in differentiating subtypes of MCI.
Lee
Kang Soo
KS
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.
Chung
Ji Hyung
JH
Lee
Kyung Hye
KH
Shin
Min-Jeong
MJ
Oh
Byoung Hoon
BH
Lee
Soo Hyung
SH
Hong
Chang Hyung
CH
D000368:Aged; D000647:Amnesia / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D015415:Biomarkers / Q000097:blood*; D054410:Chemokine CCL7 / Q000097:blood*; D003072:Cognition Disorders / Q000097:blood / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D020932:Nerve Growth Factor / Q000097:blood*; D011581:Psychological Tests; D012720:Severity of Illness Index
D015415:Biomarkers; D054410:Chemokine CCL7; D020932:Nerve Growth Factor