title: Self-assembly and evolution of homomeric protein complexes.
abstract: We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of the protein-protein interactions, and (iii) the self-assembly dynamics are hierarchical with these same subcomplexes acting as kinetic intermediates.
authors.affiliation: Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QZ, United Kingdom.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Villar
authors.forename: Alex W
authors.initials: AW
authors.lastname: Wilber
authors.forename: Alex J
authors.initials: AJ
authors.lastname: Williamson
authors.forename: Parvinder
authors.initials: P
authors.lastname: Thiara
authors.forename: Jonathan P K
authors.initials: JP
authors.lastname: Doye
authors.forename: Ard A
authors.initials: AA
authors.lastname: Louis
authors.forename: Mara N
authors.initials: MN
authors.lastname: Jochum
authors.forename: Anna C F
authors.initials: AC
authors.lastname: Lewis
authors.forename: Emmanuel D
authors.initials: ED
authors.lastname: Levy
mesh_terms: D000465:Algorithms; D008956:Models, Chemical; D009010:Monte Carlo Method; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013816:Thermodynamics
chemical_list: D011506:Proteins