title: Determinants of accelerated small intestinal transit in alcohol-related chronic pancreatitis.
abstract: Patients with chronic pancreatitis may have abnormal gastrointestinal transit, but the factors underlying these abnormalities are poorly understood. Gastrointestinal transit was assessed, in 40 male outpatients with alcohol-related chronic pancreatitis and 18 controls, by scintigraphy after a liquid meal labeled with (99m)technetium-phytate. Blood and urinary glucose, fecal fat excretion, nutritional status, and cardiovascular autonomic function were determined in all patients. The influence of diabetes mellitus, malabsorption, malnutrition, and autonomic neuropathy on abnormal gastrointestinal transit was assessed by univariate analysis and Bayesian multiple regression analysis. Accelerated gastrointestinal transit was found in 11 patients who showed abnormally rapid arrival of the meal marker to the cecum. Univariate and Bayesian analysis showed that diabetes mellitus and autonomic neuropathy had significant influences on rapid transit, which was not associated with either malabsorption or malnutrition. In conclusion, rapid gastrointestinal transit in patients with alcohol-related chronic pancreatitis is related to diabetes mellitus and autonomic neuropathy.
authors.affiliation: Department of Medicine, Londrina State University, Londrina, PR, Brazil. rosa_e_silva_luc@yahoo.com
authors.forename: Lucilene
authors.initials: L
authors.lastname: Rosa-E-Silva
authors.forename: Luiz E A
authors.initials: LE
authors.lastname: Troncon
authors.forename: Lourenço
authors.initials: L
authors.lastname: Gallo
authors.forename: Milton C
authors.initials: MC
authors.lastname: Foss
authors.forename: Afonso D C
authors.initials: AD
authors.lastname: Passos
authors.forename: Gleici C
authors.initials: GC
authors.lastname: Perdoná
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Achcar
authors.forename: Ricardo B
authors.initials: RB
authors.lastname: Oliveira
mesh_terms: D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D001499:Bayes Theorem; D015992:Body Mass Index; D002432:Cecum / Q000000981:diagnostic imaging / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000000981:diagnostic imaging / Q000503:physiopathology; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D007421:Intestine, Small / Q000503:physiopathology*; D008286:Malabsorption Syndromes / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D019512:Pancreatitis, Alcoholic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D050500:Pancreatitis, Chronic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010833:Phytic Acid; D011877:Radionuclide Imaging; D045602:Steatorrhea / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D015609:Organotechnetium Compounds; C026177:technetium phytate; D010833:Phytic Acid