title: Documentation of capsular opacification and incomplete cell migration barrier formation by ThinOptX IOL using Miyake-Apple view.
abstract: The purpose of this study was to evaluate the in situ relationship of ThinOptX intraocular lens (IOL) in a cadaveric donor eye with posterior capsular opacification (PCO), following report of high PCO rates with this IOL. A cadaveric donor eye implanted with ThinOptX IOL and received at our eye bank was fixed in 10% formalin after retrieval of corneoscleral button. The globe was sectioned at equator and evaluated from the posterior (Miyake-Apple) view. Complete iridectomy was performed and IOL evaluated from the anterior (surgeon's) view. The IOL was well centered in the bag. A thick (Grade 4) Sommering ring was seen with centripetal extension across the IOL edge margin. The anterior capsule showed fibrosis and distortion of the capsulorrhexis margin. It seems from our findings that in some cases, the edge of the ThinOptX IOL may not provide an adequate barrier to epithelial cell migration and PCO formation. This can have clinical implications which need evaluation in large clinical and histopathological studies.
authors.affiliation: Cornea, External disease and Refractive Surgery Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors.forename: Sameer
authors.initials: S
authors.lastname: Kaushal
authors.forename: Gaurav
authors.initials: G
authors.lastname: Prakash
authors.forename: Seema
authors.initials: S
authors.lastname: Sen
authors.forename: Radhika
authors.initials: R
authors.lastname: Tandon
mesh_terms: D000867:Anterior Chamber / Q000473:pathology; D002102:Cadaver; D002386:Cataract / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D002465:Cell Movement; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology / Q000503:physiopathology; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008875:Middle Aged; D010336:Pathology / Q000379:methods