title: Hereditary leukonychia totalis, acanthosis-nigricans-like lesions and hair dysplasia: a new syndrome?
abstract: Leukonychia is an ungueal discoloration or dyschromia. The hereditary form is rare. In the observations reported in the literature, leukonychia was total or sub-total, and was sometimes associated to other various symptoms. We report an original observation of hereditary leukonychia totalis in a father and two of his children, associated with acanthosis-nigricans-like lesions and hair dysplasia. These symptoms were also present in eight other members of the same family.
authors.affiliation: University of Angers, University Hospital of Angers, Dermatology Department, 4 Tue Larrey 49933 Angers, Cedex 9, France. lecorre_y@yahoo.fr
authors.forename: Yannick
authors.initials: Y
authors.lastname: Le Corre
authors.forename: Maud
authors.initials: M
authors.lastname: Steff
authors.forename: Anne
authors.initials: A
authors.lastname: Croue
authors.forename: Robert
authors.initials: R
authors.lastname: Filmon
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Verret
authors.forename: Christian
authors.initials: C
authors.lastname: Le Clech
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications* / Q000473:pathology; D002648:Child; D005220:Fathers; D005260:Female; D005799:Genes, Dominant; D006197:Hair / Q000002:abnormalities* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D009260:Nail Diseases / Q000235:genetics*; D009679:Nuclear Family; D010375:Pedigree; D013577:Syndrome