title: Antioxidant diterpenoids from the roots of Salvia barrelieri.
abstract: BACKGROUND
  The phytochemical and biological studies carried out on Salvia species showed that their extracts and constituents have various biological activities.
  
  
  OBJECTIVE
  The aim of this study was the isolation of diterpenoids from the roots of Salvia barrelieri Ettling and the determination of the antioxidant activity.
  
  
  METHODS
  Chromatographic methods were used for fractionation and isolation, respectively. Structure elucidation was established by spectroscopic methods. Five antioxidant assays were performed.
  
  
  RESULTS
  Three new abietane diterpenoids barreliol, royleanone 12-methyl ether and 7-epi-salviviridinol, and six known diterpenoids, with a known dammarane triterpenoid, pyxinol were isolated. The absolute stereochemistry of pyxinol was confirmed by X-ray analysis.
  
  
  CONCLUSIONS
  Taxodione exhibited the highest antioxidant activity among the tested compounds.
authors.affiliation: Department of General and Analytical Chemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey. ufukkolak@yahoo.com
authors.forename: Ufuk
authors.initials: U
authors.lastname: Kolak
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kabouche
authors.forename: Mehmet
authors.initials: M
authors.lastname: Oztürk
authors.forename: Zahia
authors.initials: Z
authors.lastname: Kabouche
authors.forename: Gülaçtl
authors.initials: G
authors.lastname: Topçu
authors.forename: Ayhan
authors.initials: A
authors.lastname: Ulubelen
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D027544:Salvia / Q000737:chemistry*; D019207:beta Carotene / Q000737:chemistry
chemical_list: D000975:Antioxidants; D004224:Diterpenes; D019207:beta Carotene