title: Thin film nitinol microstent for aneurysm occlusion.
abstract: Thin film nitinol produced by sputter deposition was used in the design of microstents intended to treat small vessel aneurysms. Thin film microstents were fabricated by "hot-target" dc sputter deposition. Both stress-strain curves and differential scanning calorimetry curves were generated for the film used to fabricate stents. The films used for stents had an A(f) temperature of approximately 36 degrees C allowing for body activated response from a microcatheter. The 10 microm film was only slightly radio-opaque; thus, a Td marker was attached to the stents to guide fluoroscopic delivery. Thin film microstents were tested in a flow loop with and without nitinol support skeletons to give additional radial support. Stents could be compressed into and easily delivered with <3 Fr catheters. Theoretical frictional and wall drag forces on a thin film nitinol small vessel vascular stent were calculated, and the radial force exerted by thin film stents was evaluated theoretically and experimentally. In vivo studies in swine confirmed that thin film nitinol microstents could be deployed accurately and consistently in the swine cranial vasculature.
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, 32-135 Engineering IV, Los Angeles, CA 90095, USA. yjchun@ucla.edu
authors.forename: Youngjae
authors.initials: Y
authors.lastname: Chun
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Levi
authors.forename: K P
authors.initials: KP
authors.lastname: Mohanchandra
authors.forename: Fernando
authors.initials: F
authors.lastname: Vinuela
authors.forename: Fernando
authors.initials: F
authors.lastname: Vinuela
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Carman
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000783:Aneurysm / Q000601:surgery*; D000818:Animals; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D002532:Intracranial Aneurysm / Q000601:surgery; D015607:Stents; D013552:Swine
chemical_list: D000497:Alloys; C013616:nitinol