Synthesis of yashabushidiol and its analogues and their cytotoxic activity against cancer cell lines.
A total synthesis of yashabushidiol (1a), a linear diarylheptanoid having 1,3- diol system and its analogues has been achieved by alkynylation of 3-hydroxy-5-phenyl pentanal with substituted phenyl acetylenes. All the compounds have shown significant anti-proliferative activity on human leukemia (THP-1, U-937) and melanoma (A-375) cell lines. Compounds 2a and 2b were found to be most potent with an IC(50) of 12.82 microg/mL and 12.62 microg/mL, respectively, on THP-1 leukemia cell line.
Narasimhulu
M
M
Organic Division-I, Natural Products Laboratory, Indian Institute of Chemical Technology, Hyderabad, India.
Srikanth Reddy
T
T
Chinni Mahesh
K
K
Sai Krishna
A
A
Venkateswara Rao
J
J
Venkateswarlu
Y
Y
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006536:Heptanes / Q000138:chemical synthesis* / Q000633:toxicity; D006801:Humans; D010636:Phenols / Q000138:chemical synthesis* / Q000633:toxicity
D000970:Antineoplastic Agents; D006536:Heptanes; D010636:Phenols; C542049:yashabushidiol