title: Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy.
abstract: The purpose of this study is to assess the clinical value of spatiotemporal source analysis for analyzing ictal magnetoencephalography (MEG). Ictal MEG and simultaneous scalp EEG was recorded in five patients with medically intractable frontal lobe epilepsy. Dynamic statistical parametric maps (dSPMs) were calculated at the peak of early ictal spikes for the purpose of estimating the spatiotemporal cortical source distribution. DSPM solutions were mapped onto a cortical surface, which was derived from each patient's MRI. Equivalent current dipoles (ECDs) were calculated using a single-dipole model for comparison with dSPMs. In all patients, dSPMs tended to have a localized activation, consistent with the clinically determined ictal onset zone, whereas most ECDs were considered to be inappropriate sources according to their goodness-of-fit values. Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy.
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. naoro@nmr.mgh.harvard.edu
authors.forename: Naoaki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Cole
authors.forename: Deidre
authors.initials: D
authors.lastname: von Pechmann
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Wakeman
authors.forename: Matti S
authors.initials: MS
authors.lastname: Hämäläinen
authors.forename: Hesheng
authors.initials: H
authors.lastname: Liu
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Madsen
authors.forename: Blaise F
authors.initials: BF
authors.lastname: Bourgeois
authors.forename: Steven M
authors.initials: SM
authors.lastname: Stufflebeam
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000002:abnormalities / Q000601:surgery; D003627:Data Interpretation, Statistical; D004351:Drug Resistance; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography / Q000706:statistics & numerical data*; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000927:Anticonvulsants