title: Comparison of intra-coronary cell transplantation after myocardial infarction: Autologous skeletal myoblasts versus bone marrow mesenchymal stem cells.
abstract: Cell transplantation promises restoration of cardiac function after myocardial infarction (MI). Comparison of intracoronary cell transplantation with skeletal myoblasts (SMs) versus bone marrow mesenchymal stem cells (BM-MSCs) was carried out in rabbits with MI induced by ligation of the left anterior descending artery. The infarction-affected artery was injected with SMs, BM-MSCs or cell-free medium (control) 24 h post-infarction (n = 15 per group). At baseline, there were no differences in cardiac parameters between the groups. At 4 weeks post-transplantation, left ventricular ejection fraction significantly improved and left ventricular end-diastolic diameter was significantly decreased in the cell-treated groups compared with pre-transplantation and the control group. Engrafted cells were found in all of the cell-treated rabbits. The cell-treated animals had significantly higher numbers of neovessels compared with the control. No significant difference was seen between the SM and BM-MSC groups. In conclusion, intra-coronary transplantation of SMs and BM-MSCs induced neoangiogenesis with comparable enhancements of cardiac performance and reduced cardiac remodelling in a rabbit MI model.
authors.affiliation: Cardiovascular Centre, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhu
authors.forename: X
authors.initials: X
authors.lastname: Song
authors.forename: L-J
authors.initials: LJ
authors.lastname: Jin
authors.forename: L-Y
authors.initials: LY
authors.lastname: Jin
authors.forename: P
authors.initials: P
authors.lastname: Jin
authors.forename: R
authors.initials: R
authors.lastname: Guan
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Li
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002196:Capillaries; D002478:Cells, Cultured; D003893:Desmin / Q000378:metabolism; D006334:Heart Function Tests; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D032448:Myoblasts, Skeletal / Q000166:cytology*; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000473:pathology*; D018919:Neovascularization, Physiologic; D011817:Rabbits; D016019:Survival Analysis
chemical_list: D003893:Desmin