[The effect of COX-1 and COX-3 inhibitors on blood nitric oxide concentration].
Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to different chemical groups and thus they can exert different effect on metabolism of biologically important substances. The aim of the study was to estimate the effect of two nonsteroidal anti-inflammatory drugs: COX-1 inhibitor - resveratrol (trans-3,4,'5-trihydroxystilben) which is a diet supplement, and COX-3 inhibitor - paracetamol (acetaminophen) on blood nitric oxide (NO) concentration in experimental animals.


METHODS
The examinations were performed in rats, that were administered resveratrol in a dose 2.5 and 10 mg/kg body weight and paracetamol in a dose 36 and 150 mg/kg body weight by an intragastric tube for three weeks.


RESULTS
The results were compared with control animals that were administered water instead of the drugs. Nitric oxide was determined with the use of Nitric Oxide Non-Enzymatic Assay (Oxix International).


CONCLUSIONS
In the applied experimental model, both paracetamol and resveratrol increased significantly nitric oxide concentration in blood.
Kopff
Maria
M
Uniwersytet Medyczny w Lodzi, Katedra Chemii i Biochemii Klinicznej.
Kowalczyk
Edward
E
Smigielski
Janusz
J
D000082:Acetaminophen / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D051545:Cyclooxygenase 1; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology*; D005260:Female; D008297:Male; D008565:Membrane Proteins / Q000037:antagonists & inhibitors*; D009569:Nitric Oxide / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D008565:Membrane Proteins; D013267:Stilbenes; D009569:Nitric Oxide; D000082:Acetaminophen; D051545:Cyclooxygenase 1; C496513:Ptgs1 protein, rat; D000077185:Resveratrol