title: Cyclooxygenase-2 inhibitors and other nonsteroidal anti-inflammatory drugs in the treatment of musculoskeletal conditions.
abstract: Selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat a variety of musculoskeletal conditions. The efficacy of these medications has been proved, although the risks have not been clearly delineated. Nonselective NSAIDs are associated with gastrointestinal, renal, and hematologic complications. The risks of using selective NSAIDs may include cardiovascular adverse events. The most appropriate agent should be chosen by considering the possible complications as well as the patient's risk profile.
authors.affiliation: Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Austin
authors.forename: Omar
authors.initials: O
authors.lastname: Abdul-Hadi
authors.forename: Javad
authors.initials: J
authors.lastname: Parvizi
authors.forename: Eugene R
authors.initials: ER
authors.lastname: Viscusi
authors.forename: Thomas
authors.initials: T
authors.lastname: Einhorn
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001842:Bone and Bones / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D041981:Gastrointestinal Tract / Q000187:drug effects; D006801:Humans; D009140:Musculoskeletal Diseases / Q000188:drug therapy*; D010149:Postoperative Pain / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors