title: Clavatadines C-E, guanidine alkaloids from the Australian sponge Suberea clavata.
abstract: Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds aerophobin 1 (4), purealdin L (5), and aplysinamisine II (6) were isolated from extracts of the sponge Suberea clavata by bioassay-guided fractionation using a serine protease factor XIa assay. Their structures were determined by 1D and 2D NMR spectroscopy. Compounds 1-6 exhibited weak inhibition of factor XIa.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
authors.forename: Malcolm S
authors.initials: MS
authors.lastname: Buchanan
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Deborah
authors.initials: D
authors.lastname: Wessling
authors.forename: Michael
authors.initials: M
authors.lastname: Jobling
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
authors.forename: Yunjiang
authors.initials: Y
authors.lastname: Feng
authors.forename: John N A
authors.initials: JN
authors.lastname: Hooper
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001315:Australia; D015945:Factor XIa / Q000037:antagonists & inhibitors; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D006146:Guanidines; C550884:clavatadine C; C550885:clavatadine D; C550886:clavatadine E; D015945:Factor XIa