Association of interleukin-6 -174G>C promoter polymorphism with risk of cervical cancer.
BACKGROUND
The etiology of cervical cancer is associated with excessive-inflammation-mediated tumorigenesis. Interleukin-6 (IL-6), a multifunctional cytokine, regulates inflammation and various physiological processes. We therefore aimed to evaluate the association of the IL-6 -174G>C polymorphism with predisposition to cervical cancer.


METHODS
The present case-control study comprised 160 histopathologically confirmed cases of cervical cancer and 200 healthy controls. Polymorphism for the IL-6 gene was genotyped by amplification refractory mutation system (ARMS) polymerase chain reaction (PCR).


RESULTS
We observed a significant association of the IL-6 -174CC genotype with risk of cervical cancer (OR=3.16; p=0.014). An increased risk of developing stage I tumors was found in individuals with a heterozygous (GC) genotype (OR=3.63, p=0.003). In a case-only analysis, the risk was further increased in patients consuming tobacco products (OR=3.14; p=0.033).


CONCLUSIONS
The CC genotype in the IL-6 promoter region may confer a high risk of cervical cancer, which is further modulated in patients who are tobacco users.
Gangwar
Ruchika
R
Department of Urology and Renal Transplantation, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Uttar Pradesh, India.
Mittal
Balraj
B
Mittal
Rama Devi
RD
D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000235:genetics* / Q000276:immunology*
D014408:Biomarkers, Tumor; C508600:IL6 protein, human; D015850:Interleukin-6