title: Spectrum of purpura fulminans.
abstract: Purpura Fulminans is a severe disorder of acute onset with high morbidity and mortality. It is characterized by DIC with thrombocytopenia, hyofibrinogenemia, hypothrombinemia and anemia. It most often occurs in young with sudden appearance of symmetrical, tender, ecchymotic skin lesions usually involving the lower extremities. An infectious and noninfectious etiology has been proposed. Early recognition and early therapy with appropriate antibiotics and heparin is known to limit both morbidity and mortality. This article reports 5 cases of Purpura Fulminans treated at our centre with review of etiology, pathogenesis, clinical features and treatment.
authors.affiliation: Department of Pediatrics, St John's Medical College Hospital, Bangalore, Karnataka, India. drlalitha04@yahoo.com
authors.forename: A V
authors.initials: AV
authors.lastname: Lalitha
authors.forename: D
authors.initials: D
authors.lastname: Aruna
authors.forename: Anand
authors.initials: A
authors.lastname: Prakash
authors.forename: H M
authors.initials: HM
authors.lastname: Nanjunda Swamy
authors.forename: S D
authors.initials: SD
authors.lastname: Subba Rao
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000209:etiology; D005260:Female; D005734:Gangrene / Q000209:etiology / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D055665:Purpura Fulminans / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D012871:Skin Diseases / Q000209:etiology / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants