title: Curative-intent radiation therapy as a treatment modality for appendicular and axial osteosarcoma: a preliminary retrospective evaluation of 14 dogs with the disease.
abstract: Canine osteosarcoma is a common bone malignancy associated with aggressive local disease and rapid metastasis. Current local therapeutic modalities do not provide curative-intent options for dogs with significant orthopaedic or neurologic disease, dogs which are denied amputation or dogs with non-resectable lesions. The goals of this retrospective study included the evaluation of local control, survival, and time to the development of metastases in 14 dogs treated with curative-intent radiation therapy and chemotherapy. Median local disease control was 202 days (79-777). Median survival was 209 days (79-781). Median time to metastasis was 314 days (7-645). No significant correlation was found between the outcome and pre-treatment alkaline phosphatase levels, radiographic appearance, tumour site, radiation dose or chemotherapeutics administered. In these dogs, full-course radiation therapy in conjunction with chemotherapy was not found to yield equivalent results to the standard of care options.
authors.affiliation: Animal Cancer Center, Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523-1620, USA. cwalter@colostate.edu
authors.forename: C U
authors.initials: CU
authors.lastname: Walter
authors.forename: W S
authors.initials: WS
authors.lastname: Dernell
authors.forename: S M
authors.initials: SM
authors.lastname: LaRue
authors.forename: S E
authors.initials: SE
authors.lastname: Lana
authors.forename: M H
authors.initials: MH
authors.lastname: Lafferty
authors.forename: T A
authors.initials: TA
authors.lastname: LaDue
authors.forename: S J
authors.initials: SJ
authors.lastname: Withrow