title: Genomic analysis of the adenylate cyclase-hemolysin C-terminal region of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
abstract: Adenylate cyclase-hemolysin plays an important role in the virulence of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica species. Its C-terminal region carries protective epitopes and receptor binding site for human cells. Genomic analyses of this region indicate no polymorphism in B. pertussis and B. parapertussis regions, but substantial variability in B. bronchiseptica that might be linked to the various niches of this species.
authors.affiliation: Institut Pasteur, CNRS-URA, Paris, France.
authors.forename: Viviane
authors.initials: V
authors.lastname: Chenal-Francisque
authors.forename: Valérie
authors.initials: V
authors.lastname: Caro
authors.forename: Caroline
authors.initials: C
authors.lastname: Boursaux-Eude
authors.forename: Nicole
authors.initials: N
authors.lastname: Guiso
mesh_terms: D037361:Adenylate Cyclase Toxin / Q000737:chemistry / Q000235:genetics*; D020816:Amino Acid Motifs; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D001884:Bordetella / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D014644:Genetic Variation; D023281:Genomics; D008969:Molecular Sequence Data; D010802:Phylogeny
chemical_list: D037361:Adenylate Cyclase Toxin; D001426:Bacterial Proteins