title: Total synthesis of (-)-talaumidin and (-)-galbelgin.
abstract: ( - )-Talaumidin (1) and ( - )-galbelgin (2) have been synthesized via 4-pentenoic acid as a starting material with the overall yield of about 17.8 and 16.9%, respectively. The key steps include Evans asymmetry anti-aldol reaction, TBS protection, hydroboration, oxidation, Friedel-Crafts arylation, etc.
authors.affiliation: Peking Union Medical College and Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xue
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Wang
authors.forename: Xiao-Zhen
authors.initials: XZ
authors.lastname: Jiao
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Jiang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Xiao
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Luo
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.forename: Xiao-Tian
authors.initials: XT
authors.lastname: Liang
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D005229:Fatty Acids, Monounsaturated; D005663:Furans; D017705:Lignans; C492479:talaumidin; C084077:galgravin; C116609:3-hydroxybutanal; C009785:4-pentenoic acid