Pulp revascularization of immature teeth with apical periodontitis: a clinical study.
BACKGROUND
The purpose of this study was to examine the effect of a pulpal revascularization procedure for immature necrotic teeth with apical periodontitis.


METHODS
Twelve patients, each with an immature permanent tooth with chronic or acute apical periodontitis, were recruited. A triantibiotic mix (ciprofloxacin, metronidazole, and minocycline) was used to disinfect the pulp for 1 week. Then a blood clot was created in the canal, over which grey mineral trioxide aggregate was placed. Patients were recalled periodically.


RESULTS
Six patients dropped from the study (as a result of pain or failure to induce bleeding after canal disinfection) and instead received a standard apexification procedure. Another 3 patients did not attend any recall appointments. The remaining teeth (n = 3) were found to exhibit complete root development, with a positive response to pulp testing.


CONCLUSIONS
Revascularization could be effective for managing immature permanent teeth with apical periodontitis with appropriate case selection.
Ding
Rui Yu
RY
Special Department, Peking University School and Hospital of Stomatology, Beijing, China.
Cheung
Gary Shun-pan
GS
Chen
Jie
J
Yin
Xing Zhe
XZ
Wang
Qian Qian
QQ
Zhang
Cheng Fei
CF
D017607:Aluminum Compounds / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000890:Anti-Infective Agents / Q000008:administration & dosage; D001641:Bicuspid / Q000473:pathology; D001777:Blood Coagulation / Q000502:physiology; D017610:Calcium Compounds / Q000627:therapeutic use; D002648:Child; D002939:Ciprofloxacin / Q000008:administration & dosage; D003782:Dental Pulp / Q000098:blood supply* / Q000503:physiopathology; D003786:Dental Pulp Cavity / Q000098:blood supply; D003790:Dental Pulp Necrosis / Q000628:therapy*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D007180:Incisor / Q000473:pathology; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008911:Minocycline / Q000008:administration & dosage; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009805:Odontogenesis / Q000502:physiology; D010087:Oxides / Q000627:therapeutic use; D010485:Periapical Periodontitis / Q000628:therapy*; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D018915:Root Canal Preparation / Q000379:methods; D012390:Root Canal Therapy / Q000379:methods*; D017640:Silicates / Q000627:therapeutic use; D019227:Tooth Apex / Q000503:physiopathology*; D016896:Treatment Outcome
D017607:Aluminum Compounds; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; D008795:Metronidazole; D002939:Ciprofloxacin; D008911:Minocycline