[Balb/c 3T3 cell transformation assay and its application to the screening of carcinogens].
A cell transformation assay may be an in vitro assay measuring the phenotypic conversion from normal to malignant characteristics in Balb/c 3T3 cells exposed to test chemicals, and capable of detecting carcinogens. In this article, the progress and improvement of Balb/c 3T3 cells transformation assay, and its applications in the detection of tumor initiator and promoter were reviewed.
Zhang
Lei
L
Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China. zhlcdc@sohu.com
Zeng
Yi
Y
D000818:Animals; D041702:BALB 3T3 Cells; D015197:Carcinogenicity Tests / Q000379:methods*; D002273:Carcinogens / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C
D002273:Carcinogens; D004785:Environmental Pollutants