Transcriptional responses of Haemophilus parasuis  to iron-restriction stress in vitro.
Haemophilus parasuis is the causative agent of Glässer's disease, which is responsible for the increasing economic losses in the pig industry worldwide. In this study, selective capture of transcribed sequences approach was used to investigate the transcriptional responses of H. parasuis to iron-restriction stress. Thirty-six genes were identified to be up-regulated under iron-restricted conditions. Knowledge of the genes involved in adaptation to environments encountered during disease will help understand the mechanisms of pathogenesis for this economically significant bacterium.
Xie
Qiyun
Q
Division of Animal Infectious Disease, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, 430070 Wuhan, China.
Jin
Hui
H
Luo
Rui
R
Wan
Yun
Y
Chu
Jie
J
Zhou
Hufeng
H
Shi
Bi
B
Chen
Huanchun
H
Zhou
Rui
R
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D004926:Escherichia coli; D020869:Gene Expression Profiling; D005798:Genes, Bacterial; D006192:Haemophilus Infections / Q000378:metabolism / Q000469:parasitology*; D044137:Haemophilus parasuis / Q000235:genetics*; D007501:Iron / Q000378:metabolism*; D008969:Molecular Sequence Data; D011994:Recombinant Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013312:Stress, Physiological; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism / Q000469:parasitology; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D011994:Recombinant Proteins; D007501:Iron