title: Long-term quality of life after hepatic resection: health is not simply the absence of disease.
abstract: BACKGROUND
  Due to advances in operative methods and perioperative care, mortality and morbidity following major hepatic resection have decreased substantially, making long-term quality of life (QoL) an increasingly prominent issue. We evaluated whether postoperative diagnosis was associated with long-term QoL and health in patients requiring hepatic surgery for benign or malignant disease.
  
  
  METHODS
  QoL was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 and the liver-specific QLQ-LMC21 module.
  
  
  RESULTS
  Between 2002 and 2006, 249 patients underwent hepatic surgery for malignant (76%) and benign (24%) conditions. One hundred thirty-five patients were available for QoL analysis after a mean of 26.5 months. There was no statistical difference in global QoL scores between patients with malignant and benign diseases (p = 0.367). Neither the extent of the resection (> or =2 segments vs. <2 segments; p = 0.975; OR = 0.988; 95% CI = 0.461-2.119) nor patient age had a significant influence on overall QoL (p = 0.092).
  
  
  CONCLUSIONS
  These results indicate that long-term QoL for patients who underwent liver resection for malignant disease is quite good and that a poor clinical prognosis does not seem to correlate with a poor QoL.
authors.affiliation: Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
authors.forename: Vanessa M
authors.initials: VM
authors.lastname: Banz
authors.forename: Daniel
authors.initials: D
authors.lastname: Inderbitzin
authors.forename: Regula
authors.initials: R
authors.lastname: Fankhauser
authors.forename: Peter
authors.initials: P
authors.lastname: Studer
authors.forename: Daniel
authors.initials: D
authors.lastname: Candinas
mesh_terms: D000222:Adaptation, Physiological; D000223:Adaptation, Psychological; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods* / Q000523:psychology; D006801:Humans; D008107:Liver Diseases / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011336:Probability; D011788:Quality of Life; D018570:Risk Assessment; D012737:Sex Factors; D018434:Sickness Impact Profile; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D017741:Survivors; D013997:Time Factors; D055815:Young Adult