Evidence that transduction of electromagnetic field is mediated by a force receptor.
Low-strength magnetic fields triggered onset and offset evoked potentials, indicating that the detection process was a form of sensory transduction; whether the field interacted directly with an ion channel or indirectly via a signaling cascade is unknown. By analogy with electrosensory transduction in lower life forms, we hypothesized that the evoked potentials were initiated by a force exerted by the induced electric field on an ion channel in the plasma membrane. We applied a rapid magnetic stimulus (0.2 ms) and found that it produced evoked potentials indistinguishable in latency, magnitude, and frequency from those found previously when the stimulus was 50 times slower. The ability of the field-detection system in human subjects to respond to the rapid stimulus supported the theory that the receptor potentials necessary for production of evoked potentials originated from a direct interaction between the field and an ion channel in the plasma membrane that resulted in a change in the average probability of the channel to be in the open state.
Marino
Andrew A
AA
Department of Orthopaedic Surgery, LSU Health Sciences Center, P.O. Box 33932, 1501 Kings Hwy., Shreveport, LA 71130-3932, United States. amarino@lsuhsc.edu
Carrubba
Simona
S
Frilot
Clifton
C
Chesson
Andrew L
AL
D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000328:Adult; D000368:Aged; D000818:Animals; D001921:Brain / Q000502:physiology / Q000528:radiation effects*; D002397:Catfishes; D002462:Cell Membrane / Q000502:physiology / Q000528:radiation effects; D004555:Electric Fish / Q000502:physiology; D004569:Electroencephalography / Q000379:methods*; D004574:Electromagnetic Fields; D005071:Evoked Potentials / Q000502:physiology / Q000528:radiation effects*; D005260:Female; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology / Q000528:radiation effects*; D007473:Ion Channels / Q000502:physiology / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000502:physiology / Q000528:radiation effects; D011930:Reaction Time / Q000502:physiology / Q000528:radiation effects; D012815:Signal Processing, Computer-Assisted; D015398:Signal Transduction / Q000502:physiology / Q000528:radiation effects*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
D007473:Ion Channels