title: The risk of cerebral palsy in survivors of multiple pregnancies with cofetal loss or death.
abstract: OBJECTIVE
  This study investigated the risks for cerebral palsy in survivors of multiple pregnancies with cofetal loss (< 20 weeks' gestation) or cofetal death (>or= 20 weeks' gestation).
  
  
  METHODS
  The total Western Australian population-based case-control study included 741 cases of cerebral palsy.
  
  
  RESULTS
  Antenatal cofetal loss or death occurred in 3% of all cases of cerebral palsy, which is a small but significant contribution. The odds ratio for cerebral palsy in survivors of cofetal loss that included iatrogenic pregnancy reduction was 2.65 (95% confidence interval [CI], 0.78-8.98), which gave a population-attributable proportion of 7.28% (95% CI, 0-27.5), compared with 4.25 (95% CI, 1.12-16.10) and 10.6% (95% CI, 1.0-35.6) for survivors of cofetal death.
  
  
  CONCLUSIONS
  This study quantifies the contribution of cofetal death to cerebral palsy and suggests that cofetal loss makes a similar, although somewhat smaller, contribution to the risk for cerebral palsy in survivors of multiple pregnancies.
authors.affiliation: Center for Developmental Health, Curtin University of Technology, and the Telethon Institute for Child Health Research, Perth, Western Australia.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Taylor
authors.forename: Jan
authors.initials: J
authors.lastname: de Groot
authors.forename: Eve M
authors.initials: EM
authors.lastname: Blair
authors.forename: Fiona J
authors.initials: FJ
authors.lastname: Stanley
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000453:epidemiology*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology*; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011272:Pregnancy, Multiple; D050497:Stillbirth / Q000453:epidemiology; D017741:Survivors; D014310:Triplets; D014427:Twins; D014904:Western Australia / Q000453:epidemiology