Gut microbiome modulates the toxicity of hydrazine: a metabonomic study.
The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.
Swann
Jonathan
J
Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus, London SW72AZ, UK.
Wang
Yulan
Y
Abecia
Leticia
L
Costabile
Adele
A
Tuohy
Kieran
K
Gibson
Glenn
G
Roberts
David
D
Sidaway
James
J
Jones
Huw
H
Wilson
Ian D
ID
Nicholson
Jeremy
J
Holmes
Elaine
E
D000818:Animals; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology*; D006834:Hydrazines / Q000378:metabolism / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D055432:Metabolomics / Q000379:methods; D054892:Metagenome; D051381:Rats; D017207:Rats, Sprague-Dawley
D002273:Carcinogens; D006834:Hydrazines; C029424:hydrazine