title: Effective treatment of common variable immunodeficiency associated diarrhea.
abstract: Common variable immunodeficiency disorder (CVID), the commonest symptomatic primary antibody deficiency syndrome, is characterised by recurrent bacterial infections, particularly of the upper and lower airways; it is also associated with an increased incidence of autoimmune and neoplastic disorders.CVID has a high prevalence of infectious, inflammatory and neoplastic gastrointestinal diseases. Up to 60% of the patients with non-treated CVID develop diarrhea and 10% associated idiopathic malabsorption with weight loss.The case of a 50-year-old woman with CVID-associated diarrhea, abdominal pain and bloating of one year s duration is reported. An exhaustive evaluation made for secondary causes of her symptoms was unrevealing; she was treated with loperamide and diet, without improvement. She later followed a course of oral budesonide for 3 months; her clinical symptoms disappeared and her quality of life improved.In conclusion, we report the case of a patient with CVID-related chronic diarrhea who responded well to oral budesonide treatment. This outcome provides the gastroenterologist with a new therapeutic option in this difficult group of patients.
authors.affiliation: Digestive System Research Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: H
authors.initials: H
authors.lastname: Córdova Guevara
authors.forename: L
authors.initials: L
authors.lastname: Guarner Aguilar
mesh_terms: D019819:Budesonide / Q000627:therapeutic use*; D002908:Chronic Disease; D017074:Common Variable Immunodeficiency / Q000150:complications*; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012074:Remission Induction
chemical_list: D019819:Budesonide