title: Medicine. Avoiding unintended toxicity.
authors.affiliation: Mayo Clinic, College of Medicine, Department of Neuroscience, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA. tgolde@mayo.edu
authors.forename: Todd E
authors.initials: TE
authors.lastname: Golde
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Kukar
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D010450:Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D011480:Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D051880:Receptors, Notch / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; D011480:Protease Inhibitors; D021122:Protein Subunits; D051880:Receptors, Notch; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; C498196:Aph1C protein, mouse; C498194:Aph1a protein, mouse; C498195:Aph1b protein, mouse