title: [Linear IgA disease with ocular involvement associated with ulcerative colitis].
abstract: The association of linear IgA disease (LAD), ulcerative colitis and scarring ocular involvement is very rare and represents a considerable therapeutic challenge. We report a 48-year-old male diagnosed with ulcerative colitis in 1995, who received long-term methylprednisolone therapy. Later, he developed ocular inflammation with conjunctival scarring and synechiae formation as well as episodes of vesicles. Although azathioprine was added to his regimen, the disease was not controlled. After the diagnosis of LAD was established, dapsone was added. With this therapy, the ocular inflammation decreased significantly and the methylprednisolone dose could be successfully tapered slowly without reappearance of vesicles.
authors.affiliation: Klinik und Poliklinik für Dermatologie, Klinikum der Universität Regensburg, Regensburg, Deutschland. annette.klein@klinik.uni-regensburg.de
authors.forename: A
authors.initials: A
authors.lastname: Klein
authors.forename: S M
authors.initials: SM
authors.lastname: Wenzel
authors.forename: E M
authors.initials: EM
authors.lastname: Messmer
authors.forename: M
authors.initials: M
authors.lastname: Landthaler
authors.forename: T
authors.initials: T
authors.lastname: Vogt
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D003622:Dapsone / Q000008:administration & dosage*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D007070:Immunoglobulin A; D003622:Dapsone; D008775:Methylprednisolone