title: Heterologous prime-boost vaccinations for poverty-related diseases: advantages and future prospects.
abstract: Classical vaccination approaches, based on a single vaccine administered in a homologous prime-boost schedule and optimized to induce primarily neutralizing antibodies, are unlikely to be sufficiently efficacious to prevent TB, malaria or HIV infections. Novel vaccines, capable of inducing a more powerful immune response, in particular T-cell immunity, are desperately needed. Combining different vaccine modalities that are able to complement each other and induce broad and sustainable immunity is a promising approach. This review provides an overview of heterologous prime-boost vaccination modalities currently in development for the 'big three' poverty-related diseases and emphasizes the need for innovative vaccination approaches.
authors.affiliation: Immunology and Proof of Concept, Innovation & Discovery Lab, Crucell Holland BV, Leiden, The Netherlands. katarina.radosevic@crucell.com
authors.forename: Katarina
authors.initials: K
authors.lastname: Radosević
authors.forename: Ariane
authors.initials: A
authors.lastname: Rodriguez
authors.forename: Angelique
authors.initials: A
authors.lastname: Lemckert
authors.forename: Jaap
authors.initials: J
authors.lastname: Goudsmit
mesh_terms: D015658:HIV Infections / Q000517:prevention & control; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D008288:Malaria / Q000517:prevention & control; D014376:Tuberculosis / Q000517:prevention & control; D014611:Vaccination / Q000379:methods*; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology
chemical_list: D014612:Vaccines; D019444:Vaccines, DNA; D022223:Vaccines, Subunit