Cortical expression of prolactin (PRL), growth hormone (GH) and adrenocorticotrophic hormone (ACTH) is not increased in experimental traumatic brain injury.
BACKGROUND
Cerebral cortical expression of the pituitary hormones prolactin (PRL) and growth hormone (GH) have reported in ischemic damage. Both hormones may be involved in vascular tone regulation and angiogenesis, and growth hormone is thought to be neuroprotective while prolactin stimulates astrogliosis.


METHODS
We examined expression of prolactin, growth hormone and adrenocorticotrophic hormone (ACTH) using tissue microarray technology in the controlled cortical impact model of traumatic brain injury (TBI).


RESULTS
No increased expression of these hormones was seen.


CONCLUSIONS
Unlike ischemia, traumatic brain injury does not result in up-regulation of the pituitary hormones PRL and GH in cerebral cortex.
Goodman
J C
JC
Department of Neurosurgery, MS:BCM650, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. jgoodman@bcm.tmc.edu
Cherian
L
L
Robertson
C S
CS
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism*; D016900:Neurofilament Proteins / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D014746:Vimentin / Q000378:metabolism
D018952:Antigens, CD34; D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins; D014746:Vimentin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone