Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles.
Multistep in flow: The Seyferth-Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three-step oxidation/homologation/copper(I)-catalyzed azide-alkyne cycloaddition sequence without isolation of intermediates (see scheme).
Baxendale
Ian R
IR
ITC, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Ley
Steven V
SV
Mansfield
Andrew C
AC
Smith
Christopher D
CD
D000480:Alkynes / Q000138:chemical synthesis*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis*
D000480:Alkynes; D006571:Heterocyclic Compounds; D014230:Triazoles