Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol.
The cannabinoid field is currently an active research area. Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are the most characterized endogenous cannabinoids (also known as endocannabinoids). These neuromodulators have been implicated in various physiologically relevant phenomena, including mood (Witkin et al., 2005), the immune response (Ashton, 2007), appetite (Kirkham and Tucci, 2006), reproduction (Wang et al., 2006), spasticity (Pertwee, 2002), and pain (Hohmann and Suplita, 2006). Pharmacological manipulation of AEA and 2-AG signaling should prove to have significant therapeutic applications in disorders linked to endocannabinoid signaling. One way to alter endocannabinoid signaling is to regulate the events responsible for termination of the endocannabinoid signal-cellular uptake and metabolism. However, to pharmacologically exploit AEA and/or 2-AG signaling in this way, we must first gain a better understanding of the proteins and mechanisms governing these processes. This review serves as an introduction to the endocannabinoid system with an emphasis on the proteins and events responsible for the termination of AEA and 2-AG signaling.
Yates
Marla L
ML
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University School of Pharmacy, West Lafayette, IN 47907-2091, USA.
Barker
Eric L
EL
D000581:Amidohydrolases / Q000502:physiology; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D001711:Biotransformation; D002352:Carrier Proteins / Q000502:physiology; D021941:Caveolae / Q000502:physiology; D004058:Diffusion; D063388:Endocannabinoids; D004705:Endocytosis; D005989:Glycerides / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D008084:Lipoxygenase / Q000502:physiology; D008994:Monoacylglycerol Lipases / Q000502:physiology; D010084:Oxidation-Reduction; D053284:Polyunsaturated Alkamides / Q000378:metabolism*; D015398:Signal Transduction; D000099252:Fatty Acid Amide Hydrolases
D000581:Amidohydrolases; D001095:Arachidonic Acids; D002352:Carrier Proteins; D063388:Endocannabinoids; D005989:Glycerides; D008084:Lipoxygenase; D008994:Monoacylglycerol Lipases; D053284:Polyunsaturated Alkamides; D000099252:Fatty Acid Amide Hydrolases; C094503:glyceryl 2-arachidonate; C078814:anandamide