Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia.
OBJECTIVE
The objective was to determine the value of ischemia-modified albumin (IMA) in the diagnosis of mesenteric embolism. The authors investigated whether or not plasma IMA levels rose in the acute period in a rat model of mesenteric ischemia and the related time-dependent changes.


METHODS
In this randomized, controlled, nonblinded trial, 36 mature female Wistar rats were divided into six groups: three control (Groups I, III, and V) and three ischemia (Groups II, IV, and VI). In the control groups, blood was sampled at 30 minutes (Group I), 2 hours (Group III), and 6 hours (Group V) following a simple laparotomy. In the ischemia groups, following laparotomy, the superior mesenteric artery (SMA) was clamped using a bulldog clamp, and blood samples were taken at 30 minutes (Group II), 2 hours (Group IV), and 6 hours (Group VI).


RESULTS
Plasma IMA levels in the ischemia groups were significantly higher compared to those of the control groups (p < 0.004). In addition, levels were higher in the 6-hour blood samples of the ischemia group than in the 2-hour and 30-minute samples (p < 0.001). Serum IMA was also higher in the 2-hour blood samples of the ischemia group than in the 30-minute samples (p < 0.001).


CONCLUSIONS
These preliminary findings suggest that serum IMA levels may represent a significant parameter in the early diagnosis of acute mesenteric ischemia and that further studies are necessary.
Gunduz
Abdulkadir
A
Department of Emergency Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
Turkmen
Suha
S
Turedi
Suleyman
S
Mentese
Ahmet
A
Yulug
Esin
E
Ulusoy
Hülya
H
Karahan
Suleyman Caner
SC
Topbas
Murat
M
D000818:Animals; D003250:Constriction; D004195:Disease Models, Animal; D005260:Female; D007421:Intestine, Small / Q000473:pathology; D007511:Ischemia / Q000097:blood / Q000175:diagnosis*; D019344:Lactic Acid / Q000032:analysis; D008315:Malondialdehyde / Q000032:analysis; D017538:Mesenteric Artery, Superior; D008643:Mesentery / Q000098:blood supply*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013997:Time Factors
D012709:Serum Albumin; D019344:Lactic Acid; D008315:Malondialdehyde