title: Synthesis of macrocyclic beta-strand templates by ring closing metathesis.
abstract: We report the synthesis of macrocycles 1-6 via ring closing metathesis of dienes 7-12. Addition of chlorodicyclohexylborane to thermal and microwave assisted RCM of dienes 8 and 9 markedly improves the yield. The geometric isomers of macrocycles 1-3 and 5 have been assigned using X-ray crystallography and NMR.
authors.affiliation: Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. andrew.abell@adelaide.edu.au
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Abell
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Alexander
authors.forename: Steven G
authors.initials: SG
authors.lastname: Aitken
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Chen
authors.forename: James M
authors.initials: JM
authors.lastname: Coxon
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Jones
authors.forename: Stephen B
authors.initials: SB
authors.lastname: McNabb
authors.forename: Andrew
authors.initials: A
authors.lastname: Muscroft-Taylor