Synthesis and structure-based dissection of cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs.
Dixon
Mark J
MJ
Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.
Nathubhai
Amit
A
Andersen
Ole A
OA
van Aalten
Daan M F
DM
Eggleston
Ian M
IM
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002688:Chitinases / Q000037:antagonists & inhibitors*; D004353:Drug Evaluation, Preclinical; D004591:Electrophoresis, Polyacrylamide Gel; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D019920:Photoaffinity Labels; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D010456:Peptides, Cyclic; D019920:Photoaffinity Labels; D002688:Chitinases