Kaposiform hemangioendothelioma in multiple spinal levels without skin changes.
Kaposiform hemangioendothelioma is a rare vascular tumor of childhood that is locally aggressive but has little metastatic potential and by itself is not known to be lethal. It most commonly presents as a superficial or deep soft tissue mass with associated cutaneous lesions. Kasabach-Merritt phenomenon, a condition characterized by profound thrombocytopenia and life-threatening hemorrhage, often is associated with kaposiform hemangioendothelioma. Six cases of kaposiform hemangioendothelioma have been reported in bone, two of which were located in extracraniofacial bones. We report a diagnostically challenging case of a 6-year-old girl with kaposiform hemangioendothelioma of the thoracolumbar spine without Kasabach-Merritt phenomenon or cutaneous lesions.
Lisle
Jennifer W
JW
Department of Orthopedics and Rehabilitation, University of Vermont/Fletcher Allen Health Care, 426C Stafford Hall, 95 Carrigan Avenue, Burlington, VT 05405-0084, USA. jennifer.lisle@med.uvm.edu
Bradeen
Heather A
HA
Kalof
Alexandra N
AN
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D000068579:Celecoxib; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006390:Hemangioendothelioma / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D010146:Pain / Q000209:etiology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D011720:Pyrazoles / Q000627:therapeutic use; D011859:Radiography; D012514:Sarcoma, Kaposi / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D013125:Spinal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D013449:Sulfonamides / Q000627:therapeutic use; D013577:Syndrome; D013792:Thalidomide / Q000627:therapeutic use; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D016896:Treatment Outcome
D020533:Angiogenesis Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014408:Biomarkers, Tumor; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011720:Pyrazoles; D013449:Sulfonamides; D013792:Thalidomide; D000068579:Celecoxib