The combination of the gastrointestinal integrin (α4β7) and selectin ligand enhances T-Cell migration to the reproductive tract during infection with Chlamydia trachomatis.
OBJECTIVE
Chlamydia trachomatis causes sexually transmitted infection and reproductive dysfunction worldwide. Identifying a population of endocervical T-cells to target in vaccine development is likely to enhance efficacy of a vaccine and reduce reproductive tract dysfunction.


METHODS
Endocervical samples were obtained from young women and flow cytometric analysis was used to identify lymphocytes that appeared in the genital tract in response to sexually transmitted bacterial infections caused by C. trachomatis.


RESULTS
Increased numbers of α4β7+CLA+ memory T-cells, a unique T-cell phenotype, were found in the endocervix of human female subjects infected with C. trachomatis.


CONCLUSIONS
A unique population of memory T lymphocytes expressing both α4β7 and CLA gain access to reproductive tract tissues during a sexually transmitted infection with C. trachomatis and should be considered in development of vaccines against sexually transmitted infections.
Kelly
Kathleen A
KA
Department of Pathology & Laboratory Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095-1732, USA. kkelly@mednet.ucla.edu
Wiley
Dorothy
D
Wiesmeier
Ed
E
Briskin
Michael
M
Butch
Anthony
A
Darville
Toni
T
D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology*; D002584:Cervix Uteri / Q000276:immunology* / Q000382:microbiology; D002690:Chlamydia Infections / Q000276:immunology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000276:immunology*; D005260:Female; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D039441:Integrin alpha4 / Q000276:immunology*; D039641:Integrin beta Chains / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; C063419:CTAGE1 protein, human; D039641:Integrin beta Chains; D008562:Membrane Glycoproteins; C091368:integrin beta7; D039441:Integrin alpha4