title: Laboratory identification of lupus anticoagulants.
abstract: Lupus anticoagulants (LA) are acquired autoantibodies that can cause antiphospholipid syndrome. LAs prolong phospholipid-dependent coagulation tests, acting as nonspecific inhibitors that are neutralized in the presence of excess phospholipid. However, there is no gold standard test and the testing is influenced by a number of variables. This article summarizes laboratory testing for LAs, with particular focus on technical issues and limitations of testing. Am. J. Hematol. 2009. (c) 2009 Wiley-Liss, Inc.
authors.affiliation: ARUP Laboratories, Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. kristi.smock@aruplab.com
authors.forename: Kristi J
authors.initials: KJ
authors.lastname: Smock
authors.forename: George M
authors.initials: GM
authors.lastname: Rodgers
mesh_terms: D001780:Blood Coagulation Tests / Q000379:methods; D019411:Clinical Laboratory Techniques / Q000379:methods*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood*
chemical_list: D016682:Lupus Coagulation Inhibitor