Amination of allylic alcohols in water at room temperature.
The "trick" to carrying out regiocontrolled aminations of allylic alcohols in water as the only medium is use of a nanomicelle's interior as the organic reaction solvent. When HCO(2)Me is present, along with the proper base and source of catalytic Pd, allylic amines are cleanly formed at room temperature.
Nishikata
Takashi
T
Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA.
Lipshutz
Bruce H
BH
D000498:Allyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature; D014867:Water / Q000737:chemistry
D000498:Allyl Compounds; D000588:Amines; D014867:Water; D010165:Palladium