title: Antibiotic-impregnated ventriculo-peritoneal shunts in patients at high risk of infection.
abstract: OBJECTIVE
  To determine the efficacy of antibiotic impregnated shunts (AIS) in reducing shunt infections in a population at high risk of shunt infection.
  
  
  METHODS
  From October 2005 to October 2007, patients at high risk of infection (severely disabled, not able to take care of themselves, frequent nosocomial infections) were selected from the 198 adults who underwent shunt placement.
  
  
  RESULTS
  Eighteen adults were identified (mean age 61.8 years). Six patients had AISs, and 12 patients had non-AISs. Groups did not differ in age, sex, type of hydrocephalus or hospital stay before shunting. Shunt infection occurred in 7/12 cases of the non-AIS group (58.3%) versus no infections in the AIS group. In six of seven cases, infection occurred within the first 6 months after surgery. A prevalence of S. epidermidis was detected.
  
  
  CONCLUSIONS
  We believe that in these patients AIS could be effective. Larger, prospective studies are needed in order to definitely address this issue.
authors.affiliation: Institute of Neurosurgery, Catholic University School of Medicine, l.go A. Gemelli, 8, 00168 Rome, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Albanese
authors.forename: Pasquale
authors.initials: P
authors.lastname: De Bonis
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sabatino
authors.forename: Gennaro
authors.initials: G
authors.lastname: Capone
authors.forename: Enrico
authors.initials: E
authors.lastname: Marchese
authors.forename: Andrea
authors.initials: A
authors.lastname: Vignati
authors.forename: Giulio
authors.initials: G
authors.lastname: Maira
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003428:Cross Infection / Q000188:drug therapy / Q000517:prevention & control; D006233:Persons with Disabilities; D004866:Equipment Contamination / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000601:surgery; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013207:Staphylococcal Skin Infections / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000517:prevention & control*; D016896:Treatment Outcome; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents