Smurf1 zaps the talin head.
Focal adhesion turnover is essential for cell migration. New results show that the talin head liberated from talin by calpain II cleavage has a key role in these events, and that its levels are tightly regulated by Smurf1-mediated ubiquitylation counteracted by Cdk5-mediated phosphorylation.
Critchley
David R
DR
D000818:Animals; D002154:Calpain / Q000378:metabolism; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D051360:Cyclin-Dependent Kinase 5 / Q000378:metabolism; D022001:Focal Adhesions / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D010766:Phosphorylation; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D054730:Protein Interaction Domains and Motifs / Q000502:physiology; D011554:Pseudopodia / Q000378:metabolism; D012694:Serine / Q000378:metabolism; D016608:Talin / Q000737:chemistry / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D054875:Ubiquitination
D016608:Talin; D012694:Serine; C492381:Smurf1 protein, mouse; D044767:Ubiquitin-Protein Ligases; D051360:Cyclin-Dependent Kinase 5; D002154:Calpain; D046988:Proteasome Endopeptidase Complex