Efficacy and safety of darunavir and etravirine in an antiretroviral multi-experienced youth with vertically HIV-1 infection.
Multiclass-drug resistance, often caused by poor treatment compliance, is a challenging problem in all categories of HIV-infected patients. Selective pressure is higher in youth for both biological and behavioral reasons. We report the case of a 15-year-old Caucasian male, with vertically acquired HIV-1 infection, who failed several lines of antiretroviral therapy and was successfully treated with darunavir/ritonavir and etravirine.
Rosso
Raffaella
R
Department of Infectious Diseases, University of Genoa, San Martino Hospital, Genova, Italy. Raffaella.Rosso@unige.it
Bernardini
C
C
Bruzzone
B
B
Secondo
G
G
Icardi
G
G
Viscoli
C
C
Di Biagio
A
A
D000293:Adolescent; D000069454:Darunavir; D024921:Drug Resistance, Multiple, Viral / Q000187:drug effects; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000635:transmission*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D009570:Nitriles; D011724:Pyridazines / Q000627:therapeutic use*; D011743:Pyrimidines; D019438:Ritonavir / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use*; D016896:Treatment Outcome
D017320:HIV Protease Inhibitors; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; D013449:Sulfonamides; C451734:etravirine; D019438:Ritonavir; D000069454:Darunavir