title: Linear regression analysis of the cumulative defect curve by sectors and other criteria of glaucomatous visual field progression.
abstract: OBJECTIVE
  To analyze the progression of visual field loss using sector analysis of the cumulative defect curve and other procedures.
  
  
  METHODS
  Visual fields of 260 glaucomatous eyes were analyzed over 2.8 years (SD = 1.2) with at least five examinations (mean 6.9; SD = 2.0) using Octopus 311 perimeter and TOP strategy. The authors applied Threshold Noiseless Trend (TNT) program, which performs local filtering of threshold to reduce fluctuation, and analyzed five criteria: 1) a score based on significant progression of eight sectors of the cumulative defect curve (CD); 2) a score based on the presence of points (PO) with significant progression; 3) global progression (GL) of all local deviations; 4) progression of mean defect (MD); 5) progression of the square root of loss variance (sLV). The authors estimated false diagnoses (FD), randomly reordering examinations of each patient. An index of focality of progression (FI) was obtained.
  
  
  RESULTS
  sLV presented low sensitivity and GL low specificity. CD and PO presented twice the sensitivity of MD, often proving earlier indicators. The authors observed significant progression of some of the three criteria in 17.5% of the cases when MD <6 dB and in 20.7% when MD >6 dB (FD=5.7%). Agreement between two criteria occurred in 6.8% of cases with MD <6 dB and in 11.6% when MD >6 dB (FD=1.9%). Result reproducibility in successive examinations was observed in 9.9% of cases (FD=1.3%). Focality of progression increased with MD.
  
  
  CONCLUSIONS
  PO and CD indicate suspected progression earlier than MD. Reproduction of results in successive examinations or agreement between criteria allows confirmation of progression.
authors.affiliation: University of La Laguna, Santa Cruz de Tenerife, Spain. mgdelarosa1950@gmail.com
authors.forename: Manuel
authors.initials: M
authors.lastname: Gonzalez De La Rosa
authors.forename: Marta
authors.initials: M
authors.lastname: Gonzalez-Hernandez
authors.forename: Tinguaro
authors.initials: T
authors.lastname: Diaz-Aleman
mesh_terms: D002908:Chronic Disease; D003941:Diagnostic Techniques, Ophthalmological; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000503:physiopathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014786:Vision Disorders / Q000503:physiopathology*; D014794:Visual Fields