title: Amphiphilic random glycopolymer based on phenylboronic acid: synthesis, characterization, and potential as glucose-sensitive matrix.
abstract: This study is devoted to developing amphiphilic, random glycopolymers based on phenylboronic acid, which self-assemble to form nanoparticles (NPs), as a glucose-sensitive agent. Maleimide-glucosamine was copolymerized with 3-acryl aminophenylboronic acid in methanol at 70 degrees C. Using the nanoprecipitation method, NPs with a narrow size distribution were successfully generated. Transmission electron microscopic analysis showed that the NPs were well dispersed as individual, spherically shaped particles. The swelling behavior of the NPs and the in vitro release profiles of insulin at different glucose concentrations revealed definite glucose sensitivity of the glycopolymers. Further, circular dichroism spectroscopy demonstrated that the overall tertiary structure of the released insulin was not altered compared with standard insulin. The analysis of relative cell proliferation suggested that the glycopolymer NPs had good biocompatibility. The glycopolymers that responded to changes in the glucose concentration of the surrounding environment are being aimed for use in self-regulated insulin delivery.
authors.affiliation: Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin, China.
authors.forename: Xingju
authors.initials: X
authors.lastname: Jin
authors.forename: Xinge
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Wu
authors.forename: Dayong
authors.initials: D
authors.lastname: Teng
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Chaoxing
authors.initials: C
authors.lastname: Li
mesh_terms: D001672:Biocompatible Materials; D001897:Boronic Acids / Q000737:chemistry*; D002942:Circular Dichroism; D005947:Glucose / Q000737:chemistry*; D007328:Insulin / Q000008:administration & dosage; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D001897:Boronic Acids; D007328:Insulin; D011108:Polymers; D005947:Glucose; C010686:benzeneboronic acid