title: Severe factor X deficiency in a twin pregnancy.
abstract: Factor X deficiency is a rare bleeding disorder inherited in an autosomal recessive fashion. In severe cases with a definitive bleeding phenotype, prophylaxis with prothrombin complex concentrate appears to prevent bleeding very effectively. Management of factor X-deficient pregnant patients continues to be a challenge. We present a new case of successful twin pregnancy in a severe factor X-deficient patient.
authors.affiliation: Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey.
authors.forename: M Sinan
authors.initials: MS
authors.lastname: Beksaç
authors.forename: Zeliha
authors.initials: Z
authors.lastname: Atak
authors.forename: Tülay
authors.initials: T
authors.lastname: Ozlü
mesh_terms: D000328:Adult; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D005171:Factor X Deficiency / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D014427:Twins
chemical_list: D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates