title: Brain and optic chiasmal herniations into sella after cabergoline therapy of giant prolactinoma.
abstract: Optic chiasmal herniation following dopamine agonist therapy is a rare complication in patients with giant prolactinomas. But there are a few case reports of brain and chiasmal herniation following medical therapy in such cases. We report a young man who developed secondary visual loss and seizures after 6 months of medical treatment with cabergoline for giant prolactinoma. Magnetic resonance imaging of hypothalamic pituitary region revealed optic chiasmal and frontal lobe herniation into sella. There was marginal improvement in his vision after cabergoline dose reduction. The present case report highlights frontal lobe herniation in conjunction with optic chiasmal herniation as a very rare complication of medical therapy of giant prolactinoma. Different treatment options of this condition are being discussed.
authors.affiliation: Department of Medicine and Division of Endocrinology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, India. dineshdhanwal@hotmail.com
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Dhanwal
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Sharma
mesh_terms: D000328:Adult; D000077465:Cabergoline; D018491:Dopamine Agonists / Q000009:adverse effects / Q000627:therapeutic use; D004677:Encephalocele / Q000139:chemically induced* / Q000473:pathology; D004873:Ergolines / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009897:Optic Chiasm / Q000187:drug effects* / Q000473:pathology; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015175:Prolactinoma / Q000188:drug therapy* / Q000473:pathology; D012658:Sella Turcica / Q000187:drug effects* / Q000473:pathology; D047368:Tumor Burden
chemical_list: D018491:Dopamine Agonists; D004873:Ergolines; D000077465:Cabergoline