Transplantation: sirolimus plus calcineurin inhibitors in transplantation.
A recent study reported that combination therapy with sirolimus plus either tacrolimus or ciclosporin resulted in effective immunosuppression in high-risk renal allograft recipients. Does such combination therapy really represent an advance in immunosuppressive therapy for these individuals?
Braun
William
W
Glickman Urological and Kidney Institute, Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. braunw@ccf.org
D065095:Calcineurin Inhibitors; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D020123:Sirolimus / Q000627:therapeutic use*
D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D020123:Sirolimus