Synthesis of novel cholesterol-based cationic lipids for gene delivery.
The new cholesterol-based cationic lipids B, C, and D with an ether linked spacer were synthesized by using aminopropyl chain extension with acrylonitrile. The cholesterol-based cationic lipid A with carbamoyl linkage were also synthesized in order to compare the difference in transfection efficiency of the two linkage types. To this end, GFP expression of these cationic lipids was confirmed respectively.
Kim
Bieong-Kil
BK
School of Life Sciences and Biotechnology, Kyungpook National University, Sankyukdong, Bookgu, Daegu, Republic of Korea.
Doh
Kyung-Oh
KO
Nam
Joo Hyeung
JH
Kang
Hyungu
H
Park
Jong-Gu
JG
Moon
Ik-Jae
IJ
Seu
Young-Bae
YB
D002412:Cations / Q000737:chemistry*; D045744:Cell Line, Tumor; D002784:Cholesterol / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008081:Liposomes / Q000737:chemistry; D014162:Transfection
D002412:Cations; D008055:Lipids; D008081:Liposomes; D002784:Cholesterol