title: Radiation dosimetry and biodistribution of (99m)Tc-ethylene dicysteine-deoxyglucose in patients with non-small-cell lung cancer.
abstract: OBJECTIVE
  To assess the radiation dosimetry and biodistribution of (99m)Tc-labeled ethylene dicysteine deoxyglucose ((99m)Tc-EC-DG) in patients with non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  Serial whole-body scans were acquired 0, 2, 4, 6 and 24 h after injection of (99m)Tc-EC-DG (925 MBq) in seven NSCLC patients. Radiation dosimetry, blood clearance and SPECT imaging of the primary tumor were assessed.
  
  
  RESULTS
  The critical organ was the bladder wall, with average radiation absorbed dose over all seven patients of 2.47x10(-2) mGy/MBq. The average effective dose equivalent and effective dose were 6.20x10(-3) mSv/MBq (6.89 mSv/1,110 MBq) and 5.90x10(-3) mSv/MBq (6.54 mSv/1,110 MBq), respectively. The primary tumor was visualized with SPECT in six patients. On final pathology, one patient had a granuloma, which did not enhance with (99m)Tc-EC-DG.
  
  
  CONCLUSIONS
  (99m)Tc-EC-DG has acceptable dosimetric and biodistribution properties as a diagnostic tumor-imaging agent. Future studies are planned to evaluate its diagnostic potential.
authors.affiliation: Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA. nschechter@radonc.ucsf.edu
authors.forename: Naomi R
authors.initials: NR
authors.lastname: Schechter
authors.forename: William D
authors.initials: WD
authors.lastname: Erwin
authors.forename: David J
authors.initials: DJ
authors.lastname: Yang
authors.forename: E Edmund
authors.initials: EE
authors.lastname: Kim
authors.forename: Reginald F
authors.initials: RF
authors.lastname: Munden
authors.forename: Kenneth
authors.initials: K
authors.lastname: Forster
authors.forename: Lina C
authors.initials: LC
authors.lastname: Taing
authors.forename: James D
authors.initials: JD
authors.lastname: Cox
authors.forename: Homer A
authors.initials: HA
authors.lastname: Macapinlac
authors.forename: Donald A
authors.initials: DA
authors.lastname: Podoloff
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography; D011859:Radiography; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon; D001743:Urinary Bladder / Q000528:radiation effects
chemical_list: C471673:(99m)Tc ethylenedicysteine-deoxyglucose; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals