title: Laparoscopy in the early diagnosis and management of sclerosing encapsulating peritonitis.
abstract: Sclerosing encapsulating peritonitis (SEP) is a rare and dreaded complication that can occur in patients undergoing peritoneal dialysis (PD). Although risk factors have been identified, the diagnosis is difficult and is usually made late in the disease after extensive fibrosis of the peritoneal membrane has occurred, at which point therapy is often fruitless. The high mortality rate of SEP is due to complications resulting from recurrent bowel obstruction, malnutrition, and sepsis. We report three patients with signs and symptoms suggestive of SEP all of whom had normal abdominal CT scans. Nevertheless, each patient underwent diagnostic laparoscopy, which confirmed the clinical suspicion of SEP. In each case, the diagnosis was made before extensive peritoneal fibrosis had occurred allowing therapeutic intervention at an early stage. All three patients subsequently became asymptomatic and thrived. This clinical improvement was supported by the lack of progression to overt peritoneal fibrosis on repeat laparoscopy. We conclude that a high index of suspicion in conjunction with a low threshold for diagnostic laparoscopy may be an effective strategy to establish an early diagnosis and treatment regimen for SEP. Additionally, repeat laparoscopy can be used to guide the length of therapy. These interventions may ultimately improve the long-term morbidity and mortality of SEP.
authors.affiliation: Section of Nephrology, Rush University Medical Center, 1425 W. Washington Blvd., Chicago, IL 60607, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kropp
authors.forename: Marvin
authors.initials: M
authors.lastname: Sinsakul
authors.forename: John
authors.initials: J
authors.lastname: Butsch
authors.forename: Roger
authors.initials: R
authors.lastname: Rodby
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000473:pathology* / Q000601:surgery; D010538:Peritonitis / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D012598:Sclerosis; D014057:Tomography, X-Ray Computed
chemical_list: D000893:Anti-Inflammatory Agents