Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis.
BACKGROUND
Stimulation of interleukin-22 receptor alpha-1 (IL22RA1) was reported to increase the innate immune responses in inflammatory diseases. Moreover, a reduced level of IL22RA1 was found in patients with recalcitrant CRS with nasal polyps.


OBJECTIVE
To explore association between single nucleotide polymorphisms (SNPs) in IL22RA1 and severe CRS.


METHODS
We extracted DNA from 206 cases with severe CRS and 196 postal code-matched controls. Twenty-three SNPs in the IL22RA1 gene were selected from the pooling-based genome-wide association study and from the CEU HapMap dataset and genotyped. PLINK software was used to determine association.


RESULTS
After Bonferroni correction, three SNPs (rs4292900 P(nom) = 0.0006, OR = 1.757; rs4648936 P(nom) = 0.0011, OR = 1.716; rs16829225 P(nom) = 0.0014, OR = 1.977) show significant differences in allelic frequencies between cases and controls.


CONCLUSIONS
Polymorphisms in IL22RA1 are associated with severe CRS. Replication and functional studies are involved to better understand the mechanism by which these polymorphisms contribute to the pathogenesis of CRS.
Endam
Leandra Mfuna
LM
Department of Otolaryngology, Hôtel-Dieu Hospital, Montreal University, Montreal, PQ, Canada.
Bossé
Yohan
Y
Filali-Mouhim
Abdelali
A
Cormier
Chantale
C
Boisvert
Pierre
P
Boulet
Louis-Philippe
LP
Hudson
Thomas J
TJ
Desrosiers
Martin
M
D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D049670:History, 17th Century; D006801:Humans; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D018123:Receptors, Interleukin / Q000235:genetics*; D012220:Rhinitis / Q000235:genetics*; D012852:Sinusitis / Q000235:genetics*; D011795:Surveys and Questionnaires
C433253:IL22RA2 protein, human; D018123:Receptors, Interleukin