title: Piroxicam and carboplatin as a combination treatment of canine oral non-tonsillar squamous cell carcinoma: a pilot study and a literature review of a canine model of human head and neck squamous cell carcinoma.
abstract: Results of the treatment with a combination of carboplatin and piroxicam in seven dogs with advanced non-tonsillar oral squamous cell carcinoma (SCC) were retrospectively analysed. This multi-agent protocol was well tolerated by all dogs and resulted in a complete regression of the tumour without additional surgery in four of seven patients. Additional surgery was necessary to remove a metastatic lymph node in one dog and residual tumour in a second dog, which achieved a partial response following medical therapy. Median follow-up for all the dogs was 534 days, while the time-to-recurrence, time-to-progression and overall survival for this group of patients have not yet been reached. Our study, although limited in number of animals, suggests that this multiagent approach is a useful treatment option for oral non-tonsillar SCC in dogs and warrants wider application.
authors.affiliation: De Ottenhorst, clinic for companion animal medicine, Terneuzen, The Netherlands. jpdevos@zeelandnet.nl
authors.forename: J P
authors.initials: JP
authors.lastname: de Vos
authors.forename: A G D
authors.initials: AG
authors.lastname: Burm
authors.forename: A P
authors.initials: AP
authors.lastname: Focker
authors.forename: H
authors.initials: H
authors.lastname: Boschloo
authors.forename: M
authors.initials: M
authors.lastname: Karsijns
authors.forename: I
authors.initials: I
authors.lastname: van der Waal