[Effects of jingtian tongmai recipe on atherosclerotic plaque in rabbits].
OBJECTIVE
To evaluate the inhibiting effects of Jingtian Tongmai Recipe (JTTMR) in different dosages on atherosclerotic plaque using the arteriosclerosis rabbit model induced by high cholesterol diet supplemented with immunological injury.


METHODS
Fifty-four healthy New Zealand rabbits were randomly divided into six groups: the normal control group, the model group, the Xuezhikang (XZK) treated group and the three JTTMR treated groups treated respectively with low (1.29 g/kg/day), medium (2.57 g/kg/day) and high (5.14 g/kg/day) dosage of JTTMR. Indexes including serum lipids, C-reactive protein (CRP), and area ratio of aortic plaque/intima (PIR), and intima-media thickness ratio (IMT) were examined.


RESULTS
Comparison of blood lipids showed that serum levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) were higher significantly in the model group than in the normal group (P<0.05); TC and LDL-C were lower in the XZK group and the JTTMR groups than in the model group (P<0.05); and these indexes were significantly lower in the medium dose JTTMR group than those in the low and high dose JTTMR groups (P<0.05); while no significant difference of TG between the model group, the JTTMR groups and the XZK group were observed (P>0.05). As for level of high-density lipoprotein cholesterol (HDL-C), that in the XZK group and high dose JTTMR group was higher than that in the other 4 groups (P<0.05). Comparison of CRP showed that it was higher in the model group than in the normal group (P<0.05), while the difference among the other 4 groups was insignificant (P>0.05). No plaque and increase of intima/media thickness was found in the normal group; either PIR or IMT were lesser in the JTTMR groups than those in the model group (P<0.05), and comparison among the three JTTMR groups showed those in the medium dose group was the least (P<0.05).


CONCLUSIONS
JTTMR has arteriosclerosis inhibiting effect, which might be realized through its anti-inflammatory and lipids regulating actions, but the effects are not dose-dependent. The optimal effect is showed by using medium dose of JTTMR, equivalent to the dose used for human adult.
Zhao
Cui-Xia
CX
Xinjiang Medical University, Urumqi.
Kasimu
Rena
R
Wang
Xiao-Mei
XM
D000818:Animals; D001011:Aorta / Q000473:pathology*; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy; D011817:Rabbits; D011897:Random Allocation
D004365:Drugs, Chinese Herbal; D008055:Lipids; D002097:C-Reactive Protein