title: A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis.
abstract: BACKGROUND
  A recent study reported an association between rs2234693, which influences enhancer activity levels in estrogen receptor alpha gene (ESR1), and schizophrenia. This study reported that schizophrenic patients with the CC genotype have significantly lower ESR1 mRNA levels in the prefrontal cortex than patients with other genotypes. The symptoms of methamphetamine induced psychosis are similar to those of paranoid type schizophrenia. Therefore, we conducted an association analysis of rs2234693 with Japanese methamphetamine induced psychosis patients.
  
  
  METHODS
  Using rs2234693, we conducted a genetic association analysis of case-control samples (197 methamphetamine induced psychosis patients and 197 healthy controls). The age and sex of the control subjects did not differ from those of the methamphetamine induced psychosis patients.
  
  
  RESULTS
  We detected a significant association between ESR1 and methamphetamine induced psychosis patients in allele/genotype-wise analysis. For further interpretation of these associations, we performed single marker analysis of subjects divided by sex. Rs2234693 was associated with male methamphetamine induced psychosis.
  
  
  CONCLUSIONS
  Our results suggest that rs2234693 in ESR1 may play a role in the pathophysiology of Japanese methamphetamine induced psychosis patients.
authors.affiliation: Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. tarok@fujita-hu.ac.jp
authors.forename: Taro
authors.initials: T
authors.lastname: Kishi
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kitajima
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamanouchi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Kawashima
authors.forename: Tomo
authors.initials: T
authors.lastname: Okochi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tsunoka
authors.forename: Takenori
authors.initials: T
authors.lastname: Okumura
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Yamada
authors.forename: Naohisa
authors.initials: N
authors.lastname: Uchimura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sora
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000235:genetics* / Q000523:psychology; D044466:Asian People / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000187:drug effects / Q000235:genetics*; D011605:Psychoses, Substance-Induced / Q000235:genetics* / Q000523:psychology
chemical_list: D047628:Estrogen Receptor alpha; D008694:Methamphetamine