title: Ethanol intake during lactation alters milk nutrient composition and growth and mineral status of rat pups.
abstract: Lactating Wistar rats were fed a liquid diet containing either ethanol [ethanol-fed group (EFG)] or an isocaloric amount of carbohydrate [pair-fed group (PFG)] from day 1 postpartum up to day 14 of lactation, to investigate micro/macronutrient milk composition and the mineral status of pups. EFG presented a reduction of daily milk production and milk composition was significantly higher in protein and lower in carbohydrate, while the lipid content was similar to that of PFG. When compared to PFG, the milk of EFG had a decreased proportion of C22:6 n-3 fatty acid and an increase in medium-chain fatty acids and of several minerals. Pups of EFG showed reduced growth and a lower concentration of Cu and Sr in plasma and lower concentrations of Ca, P and Cl, and higher concentrations of Cd in the brain. We conclude that maternal EtOH intake greatly impairs lactational performance and modifies the mineral status of pups.
authors.affiliation: Instituto de Nutrição Josué de Castro, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, RJ, Brazil.
authors.forename: Cíntia R P
authors.initials: CR
authors.lastname: Azara
authors.forename: Ingrid C
authors.initials: IC
authors.lastname: Maia
authors.forename: Carolina N
authors.initials: CN
authors.lastname: Rangel
authors.forename: Mário A C
authors.initials: MA
authors.lastname: Silva-Neto
authors.forename: Renata F B
authors.initials: RF
authors.lastname: Serpa
authors.forename: Edgar F O
authors.initials: EF
authors.lastname: De Jesus
authors.forename: Maria G Tavares
authors.initials: MG
authors.lastname: Do Carmo
authors.forename: Eliane
authors.initials: E
authors.lastname: Fialho
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling / Q000254:growth & development*; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000737:chemistry* / Q000187:drug effects; D008892:Milk / Q000737:chemistry / Q000187:drug effects*; D008903:Minerals / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D004040:Dietary Carbohydrates; D008903:Minerals; D000431:Ethanol