"Developmental mechanics": cellular patterns controlled by adhesion, cortical tension and cell division.
How embryos are shaped during development has inspired the work of many, embryologists, geneticists, but also mathematicians such as Turing, and physicists. Despite the inherent complexity of the problems it tackles, developmental biology has produced one of the most spectacular conceptual achievements, demonstrating that embryos are built with conserved molecules that orchestrate pattern and morphogenesis. As the logic of development now emerges, new challenges arise, such as how tissue mechanics is controlled. Quantitative approaches and computational models are essential to predict tissue organization and cell shapes. I review briefly how physical concepts have fueled this research in the past decades.
Lecuit
Thomas
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IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy case 907, 13288 Marseille Cedex 09, France.