title: Transplantation: sirolimus plus calcineurin inhibitors in transplantation.
abstract: A recent study reported that combination therapy with sirolimus plus either tacrolimus or ciclosporin resulted in effective immunosuppression in high-risk renal allograft recipients. Does such combination therapy really represent an advance in immunosuppressive therapy for these individuals?
authors.affiliation: Glickman Urological and Kidney Institute, Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. braunw@ccf.org
authors.forename: William
authors.initials: W
authors.lastname: Braun
mesh_terms: D065095:Calcineurin Inhibitors; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D020123:Sirolimus / Q000627:therapeutic use*
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D020123:Sirolimus