title: Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists.
abstract: H(3)R inverse agonists based on an aminopropoxy-phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse model of recognition memory.
authors.affiliation: UCB New Medicines, Chemin du Foriest, 1420 Braine-L'Alleud, Belgium.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Célanire
authors.forename: Maikel
authors.initials: M
authors.lastname: Wijtmans
authors.forename: Bernard
authors.initials: B
authors.lastname: Christophe
authors.forename: Philippe
authors.initials: P
authors.lastname: Collart
authors.forename: Iwan
authors.initials: I
authors.lastname: de Esch
authors.forename: Donald
authors.initials: D
authors.lastname: Dassesse
authors.forename: Christel
authors.initials: C
authors.lastname: Delaunoy
authors.forename: Frédéric
authors.initials: F
authors.lastname: Denonne
authors.forename: Véronique
authors.initials: V
authors.lastname: Durieu
authors.forename: Edith
authors.initials: E
authors.lastname: Gelens
authors.forename: Michel
authors.initials: M
authors.lastname: Gillard
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Lallemand
authors.forename: Yves
authors.initials: Y
authors.lastname: Lamberty
authors.forename: Florence
authors.initials: F
authors.lastname: Lebon
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Nicolas
authors.forename: Luc
authors.initials: L
authors.lastname: Quéré
authors.forename: Erwin
authors.initials: E
authors.lastname: Snip
authors.forename: Alain
authors.initials: A
authors.lastname: Vanbellinghen
authors.forename: Nathalie
authors.initials: N
authors.lastname: Van Houtvin
authors.forename: Valérie
authors.initials: V
authors.lastname: Verbois
authors.forename: Henk
authors.initials: H
authors.lastname: Timmerman
authors.forename: Patrice
authors.initials: P
authors.lastname: Talaga
authors.forename: Rob
authors.initials: R
authors.lastname: Leurs
authors.forename: Laurent
authors.initials: L
authors.lastname: Provins
mesh_terms: D000818:Animals; D016466:CHO Cells; D018938:Caco-2 Cells; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D015195:Drug Design; D054314:Drug Inverse Agonism; D054828:Histamine H3 Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000737:chemistry; D051379:Mice; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018100:Receptors, Histamine H3 / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D054828:Histamine H3 Antagonists; D007093:Imidazoles; D010080:Oxazoles; D018100:Receptors, Histamine H3; C029899:imidazole