Quinine is bactericidal.
OBJECTIVE
To determine the antibacterial properties of Quinine dihydrochloride and its MIC.


METHODS
A Quasi-Experimental study was conducted at the Jinnah Postgraduate Medical Centre, Karachi from July 2006 to November 2006. Two hundred samples of pus, blood, sputum and ascitic fluid, from hospitalized adult patients from Medicine ward (W-7) having different Bacterial infections were studied. Proforma was filled to document the demographic details. Samples were collected from different sites, isolated, identified and checked for antimicrobial susceptibility of quinine dihydrochloride by standard methods.


RESULTS
Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa and Salmonella typhi were inhibited at MIC of 125 g/ml. Streptococcus pyogenes was inhibited at MIC of 31.25 g/ml of quinine dihydrochloride (Dilution ranges from 31.25 g/ml to 1000 g/ml).


CONCLUSIONS
The concomitant antimalarial and antibacterial action of Quinine dihydrochloride may be beneficial in developing countries adding to cost effectiveness of treatment provided to patients belonging to low socioeconomic group.
Kharal
Saleem Ahmed
SA
Department of Microbiology, BMSI, Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pakistan.
Hussain
Qurban
Q
Ali
Shujat
S
Fakhuruddin
D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010154:Pakistan; D011514:Proteus vulgaris / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011803:Quinine / Q000494:pharmacology*; D012485:Salmonella typhi / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D055815:Young Adult
D000962:Antimalarials; D011803:Quinine