title: Cardiac troponin I in canine patients with lymphoma and osteosarcoma receiving doxorubicin: comparison with clinical heart disease in a retrospective analysis.
abstract: The cumulative cardiotoxicity that occurs as a result of doxorubicin chemotherapy is irreversible and can affect both quality and quantity of life for the cancer patient. Cardiac troponin I (cTnI) is a sensitive and specific marker of cardiomyocyte death. The purpose of this retrospective study was to evaluate serum concentrations of cTnI in dogs with lymphoma or osteosarcoma given doxorubicin chemotherapy, and with known cardiac outcome, based on a minimum assessment by physical examination and thoracic radiography. Serum samples were also available for cTnI measurement from seven healthy dogs given intracoronary doxorubicin. Serial serum samples obtained before, during and after doxorubicin chemotherapy showed increased cTnI concentrations in some clinical patients following chemotherapy (P = 0.0083 compared to baseline), but this did not correlate with clinical signs of cardiomyopathy. In dogs that subsequently developed cardiomyopathy however, serum cTnI concentrations were elevated before clinical signs became evident (confirmed with echocardiography).
authors.affiliation: Animal Cancer Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. seltingk@missouri.edu
authors.forename: K A
authors.initials: KA
authors.lastname: Selting
authors.forename: S E
authors.initials: SE
authors.lastname: Lana
authors.forename: G K
authors.initials: GK
authors.lastname: Ogilvie
authors.forename: A
authors.initials: A
authors.lastname: Olmstead
authors.forename: D L
authors.initials: DL
authors.lastname: Mykles
authors.forename: J
authors.initials: J
authors.lastname: Bright
authors.forename: K L
authors.initials: KL
authors.lastname: Richardson
authors.forename: J A
authors.initials: JA
authors.lastname: Walton
authors.forename: E
authors.initials: E
authors.lastname: Monnet
authors.forename: M J
authors.initials: MJ
authors.lastname: Fettman