Inhibition of protein kinase CK2 induces E2F1 nuclear export, formation of p21/E2F1 complexes and suppression of DNA synthesis in normal human epidermal keratinocytes.
Isaeva
Antonia Rumenova
AR
Mitev
Vanyo Ivanov
VI
D021581:Active Transport, Cell Nucleus; D047390:Casein Kinase II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism*; D004261:DNA Replication / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D050687:E2F1 Transcription Factor / Q000378:metabolism*; D004817:Epidermis / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects* / Q000201:enzymology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014230:Triazoles / Q000494:pharmacology*
C405354:4,5,6,7-tetrabromobenzotriazole; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D050687:E2F1 Transcription Factor; C493753:E2F1 protein, human; C489427:MYC protein, human; D047428:Protein Kinase Inhibitors; D016271:Proto-Oncogene Proteins c-myc; D014230:Triazoles; D047390:Casein Kinase II