Drug-induced Lyell and Stevens-Johnson syndromes.
1) Lyell syndrome is characterised by toxic epidermal necrolysis in which epidermal detachment affects more than 30% of the body surface area. Stevens-Johnson syndrome is a minor form affecting less than 10% of the body surface area; 2) Patients who present with these cutaneous symptoms, along with throat pain, red eyes and a damaged or detached oral mucosa must be hospitalised immediately; 3) Lyell syndrome is exclusively caused by drugs while Stevens-Johnson syndrome can also be caused by bacteria and viruses. Rapid withdrawal of the drug improves prognosis.
D000493:Allopurinol / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D000927:Anticonvulsants / Q000009:adverse effects*; D004892:Erythema Multiforme / Q000150:complications / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D013449:Sulfonamides / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D013449:Sulfonamides; D000493:Allopurinol; D015662:Trimethoprim, Sulfamethoxazole Drug Combination