title: "On-off" multivalent recognition: degradable dendrons for temporary high-affinity DNA binding.
abstract: Now you bind it--now you don't! Chemical degradation of a dendritic scaffold allows multivalent interactions with DNA to be "switched off" as the multivalent array of ligands breaks down into smaller fragments, offering an approach by which a molecule can be temporarily endowed with high affinity for a biological target--an important concept in the development of new synthetic systems to intervene in biological pathways.
authors.affiliation: Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Welsh
authors.forename: Simon P
authors.initials: SP
authors.lastname: Jones
authors.forename: David K
authors.initials: DK
authors.lastname: Smith
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D004247:DNA; C427203:calf thymus DNA