Regulation of breast cancer metastasis by atypical chemokine receptors.
The interaction between chemokines and their G-protein-coupled receptors plays an important role in promoting metastasis of different kinds of human cancers. However, the expression of an atypical chemokine receptor, CCX-CKR, which serves as a decoy receptor to attract chemokines, inhibits the growth and metastasis of breast cancer by sequestration of chemokines.
Cheng
Xiaoyun
X
Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Hung
Mien-Chie
MC
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D006801:Humans; D009362:Neoplasm Metastasis; D054388:Receptors, CCR / Q000502:physiology*
C408223:ACKR4 protein, human; D054388:Receptors, CCR