[Antibiotic management of presumptive bacterial meningitis in adults (rational, methods, course, and follow-up)].
The annual incidence of community acquired meningitis ranges between 0.6 and four per 100,000 adults in industrialized countries. The most common causative bacteria are Streptococcus pneumoniae, Neisseria meningitidis, Listeria monocytogenes. The emergence of resistance to antibiotics, especially for S. pneumoniae, could explain the clinical failure of third generation cephalosporins used to treat adults with S. pneumoniae meningitis. The present therapeutic suggestions are more based on the extrapolation of an experimental model than on relevant clinical trials.
Ansart
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Service des maladies infectieuses, CHU Cavale-Blanche, boulevard Tanguy-Prigent, 29609 Brest cedex, France. severine.ansart@chu-brest.fr
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000188:drug therapy; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D008584:Meningitis, Listeria / Q000188:drug therapy; D008585:Meningitis, Meningococcal / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009345:Neisseria meningitidis; D011008:Pneumococcal Infections / Q000188:drug therapy; D055815:Young Adult
D000900:Anti-Bacterial Agents