Effect of gamma-ray irradiation on degradation of di(2-ethylhexyl)phthalate in polyvinyl chloride sheet.
The risk assessment of di(2-ethylhexyl)phthalate (DEHP) migration from polyvinyl chloride (PVC) medical devices is an important issue for patients. The aim of this study was to determine DEHP degradation and migration from PVC sheets. To this end, the method for the simultaneous determination of DEHP and its breakdown products (mono(2-ethylhexyl)phthalate (MEHP) and phthalic acid (PA)) was improved. Their migration levels from 0 to 50 kGy gamma-ray irradiated PVC sheets were determined. DEHP migration level decreased in proportion to the dose of gamma-ray irradiation, while MEHP and PA migration levels increased. The hardness and the elastic modulus of PVC sheets were examined, but no clear relationship between DEHP migration and these parameters was observed.
Ito
Rie
R
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. rie-ito@hoshi.ac.jp
Miura
Naoko
N
Ushiro
Masaru
M
Kawaguchi
Migaku
M
Nakamura
Hiroko
H
Iguchi
Hirofumi
H
Ogino
Jun-Ichi
J
Oishi
Manabu
M
Wakui
Nobuyuki
N
Iwasaki
Yusuke
Y
Saito
Koichi
K
Nakazawa
Hiroyuki
H
D004051:Diethylhexyl Phthalate / Q000031:analogs & derivatives / Q000737:chemistry*; D004340:Drug Contamination; D004864:Equipment and Supplies / Q000009:adverse effects; D005720:Gamma Rays; D010795:Phthalic Acids / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry / Q000528:radiation effects*
D010795:Phthalic Acids; C032279:phthalic acid; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate; C016599:mono-(2-ethylhexyl)phthalate