Regioselective and sequential reactivity of activated 2,5-diketopiperazines.
The electrophilic reactivity of Boc-DKPs has been studied. Thanks to Boc activation, the opening ability of carbonyl lactam groups is enhanced. According to experimental conditions, this enabled the synthesis of Boc-amino acid derivatives or original dipeptides via a regioselective and sequential way.
Farran
Daniel
D
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-Université Montpellier 1-Université Montpellier 2, Bâtiment Chimie (17), Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
Echalier
Delphine
D
Martinez
Jean
J
Dewynter
Georges
G
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry; D054659:Diketopiperazines / Q000737:chemistry*; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000596:Amino Acids; D054659:Diketopiperazines; D004151:Dipeptides