title: Linac-based or robotic image-guided stereotactic radiotherapy for isolated lymph node recurrent prostate cancer.
abstract: We report on 14 patients treated with linac- or robotic image-guided stereotactic radiotherapy for isolated lymph node recurrence from prostate cancer, up to the mean dose of 30Gy/3 fractions. At the mean follow-up of 18.6months, five patients experienced clinical out-field progression. Toxicity was minimal. Further investigation is warranted in order to identify the patients that benefit most from this treatment modality and to define the optimal association of such local approach with androgen deprivation. Hopefully, effective local therapy might reduce the burden of systemic therapies given to the recurrent/metastatic prostate cancer patients.
authors.affiliation: Department of Radiotherapy, European Institute of Oncology, Milan, Italy. barbara.jereczek@ieo.it
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Jereczek-Fossa
authors.forename: Laura
authors.initials: L
authors.lastname: Fariselli
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Beltramo
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Catalano
authors.forename: Flavia
authors.initials: F
authors.lastname: Serafini
authors.forename: Cristina
authors.initials: C
authors.lastname: Garibaldi
authors.forename: Raffaella
authors.initials: R
authors.lastname: Cambria
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Brait
authors.forename: Marco
authors.initials: M
authors.lastname: Possanzini
authors.forename: Livia C
authors.initials: LC
authors.lastname: Bianchi
authors.forename: Andrea
authors.initials: A
authors.lastname: Vavassori
authors.forename: Dario
authors.initials: D
authors.lastname: Zerini
authors.forename: Franco
authors.initials: F
authors.lastname: Orsi
authors.forename: Ottavio
authors.initials: O
authors.lastname: de Cobelli
authors.forename: Roberto
authors.initials: R
authors.lastname: Orecchia
mesh_terms: D000368:Aged; D015331:Cohort Studies; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000528:radiation effects*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D016634:Radiosurgery / Q000295:instrumentation* / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000295:instrumentation / Q000379:methods; D012189:Retrospective Studies; D018570:Risk Assessment; D012371:Robotics / Q000379:methods*; D016019:Survival Analysis; D016896:Treatment Outcome