title: Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages.
abstract: Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN. All patients with gain of REL were unmutated for IGHV (p=0.03). Gain of MYCN was associated with increased mRNA expression (p=0.005), suggesting a pathogenic role for MYCN. Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.
authors.affiliation: Service d'hématologie biologique, CHU Pitié-Salpêtrière, Université Paris 6, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Chapiro
authors.forename: Nathalie
authors.initials: N
authors.lastname: Leporrier
authors.forename: Isabelle
authors.initials: I
authors.lastname: Radford-Weiss
authors.forename: Christian
authors.initials: C
authors.lastname: Bastard
authors.forename: Hossein
authors.initials: H
authors.lastname: Mossafa
authors.forename: Dominique
authors.initials: D
authors.lastname: Leroux
authors.forename: Isabelle
authors.initials: I
authors.lastname: Tigaud
authors.forename: Marc
authors.initials: M
authors.lastname: De Braekeleer
authors.forename: Christine
authors.initials: C
authors.lastname: Terré
authors.forename: Françoise
authors.initials: F
authors.lastname: Brizard
authors.forename: Evelyne
authors.initials: E
authors.lastname: Callet-Bauchu
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Struski
authors.forename: Lauren
authors.initials: L
authors.lastname: Veronese
authors.forename: Sandra
authors.initials: S
authors.lastname: Fert-Ferrer
authors.forename: Sylvie
authors.initials: S
authors.lastname: Taviaux
authors.forename: Claude
authors.initials: C
authors.lastname: Lesty
authors.forename: Frédéric
authors.initials: F
authors.lastname: Davi
authors.forename: Hélène
authors.initials: H
authors.lastname: Merle-Béral
authors.forename: Olivier A
authors.initials: OA
authors.lastname: Bernard
authors.forename: Laurent
authors.initials: L
authors.lastname: Sutton
authors.forename: Sophie D
authors.initials: SD
authors.lastname: Raynaud
authors.forename: Florence
authors.initials: F
authors.lastname: Nguyen-Khac
mesh_terms: D002869:Chromosome Aberrations; D002889:Chromosomes, Human, Pair 2; D018628:Gene Dosage; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*