Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle.
The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia.
Murata
Kazuya
K
School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
Nakao
Kikuyo
K
Hirata
Noriko
N
Namba
Kensuke
K
Nomi
Takao
T
Kitamura
Yoshihisa
Y
Moriyama
Kenzo
K
Shintani
Takahiro
T
Iinuma
Munekazu
M
Matsuda
Hideaki
H
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005054:Eugenol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D031721:Piper betle / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D010936:Plant Extracts; C051268:2-hydroxychavicol; D005054:Eugenol; D014969:Xanthine Oxidase