Systems biology makes it personal.
Systems biology promises to personalize medicine via network-based biomarkers that predict therapeutic effectiveness. Toward this goal, Chang et al. (2009) recently introduced a systems-based approach to break down oncogenic signaling networks into modules that predict the effectiveness of pathway-specific therapeutics.
Brynildsen
Mark P
MP
Howard Hughes Medical Institute, Biomedical Engineering Department, Center for BioDynamics and Center for Applied Biotechnology, Boston University, 44 Cummington Street, Boston, MA 02215, USA.
Collins
James J
JJ
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D054316:Biomarkers, Pharmacological / Q000032:analysis*; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*; D015398:Signal Transduction; D049490:Systems Biology; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D054316:Biomarkers, Pharmacological