Association of injury severity, MRI-results and ApoE genotype with 1-year outcome in mainly mild TBI: a preliminary study.
OBJECTIVE
To study the ability of MRI findings, apolipoprotein E (ApoE) genotype, the Glasgow Coma Score (GCS) and duration of post-traumatic amnesia (PTA) to predict the 1-year outcome in traumatic brain injury (TBI).


METHODS
A prospective study in unselected emergency room patients with an acute TBI, followed for 1 year.


METHODS
Thirty-three consecutive patients were studied. The TBI severity was assessed with GCS and duration of PTA. Brain MRI scans were obtained within approximately 1 week post-injury. The ApoE genotypes were determined by standard methods. The outcome was evaluated with the Head Injury Symptom Checklist and the Glasgow Outcome Scale (extended) 1 year after the injury. The prognostic value of the explanatory variables was evaluated with multiple linear regression analysis.


RESULTS
The presence of traumatic axonal injury lesions or contusions in MRI and duration of PTA were independent predictors of poor outcome. The ApoE genotype and GCS were not associated with outcome.


CONCLUSIONS
In multivariate models, the duration of PTA and acute MRI are the best predictors of 1-year outcome in TBI, whereas the prognostic values of GCS and ApoE are modest. The dominating role of GCS in assessing TBI severity should be questioned.
Hiekkanen
Heli
H
Department of Neurology, Turku University Central Hospital, Turku, Finland.
Kurki
Timo
T
Brandstack
Nina
N
Kairisto
Veli
V
Tenovuo
Olli
O
D000328:Adult; D000647:Amnesia / Q000150:complications*; D001057:Apolipoproteins E / Q000235:genetics*; D001930:Brain Injuries / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000534:rehabilitation; D005260:Female; D005387:Finland; D005838:Genotype; D015600:Glasgow Coma Scale; D023261:Glasgow Outcome Scale; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D020127:Recovery of Function; D012307:Risk Factors; D016896:Treatment Outcome
D001057:Apolipoproteins E