Delayed liver injury and impaired hepatocyte proliferation after carbon tetrachloride exposure in BPOZ2-deficient mice.
BPOZ2 is a tumor suppressive mediator in PTEN signaling pathway and plays an important role in cell proliferation. In this study, we investigated the physiology functions of BPOZ2 in CCl(4)-induced liver injury and hepatocyte proliferation afterwards. After acute CCl(4) administration, BPOZ2 null mice exhibited delayed liver injury and impaired hepatocyte proliferation, which was accompanied by altered kinetics of CYP2E1 protein expression, compromised cyclin D1 expression and shortened duration of ERK activation. These results for the first time define that BPOZ2 is an important regulator involved in the injury and repair process induced by acute CC1(4) administration in mouse liver.
Zhang
Feng
F
Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shu
Runzhe
R
Wu
Xiaolin
X
Zhao
Xiaoping
X
Feng
Dechun
D
Wang
Long
L
Lu
Shunyuan
S
Liu
Qiaoling
Q
Xiang
Yougui
Y
Fei
Jian
J
Huang
Lei
L
Wang
Zhugang
Z
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D049109:Cell Proliferation / Q000187:drug effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D005260:Female; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D013997:Time Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000502:physiology*
D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins; D002251:Carbon Tetrachloride; D000410:Alanine Transaminase