title: The effects of Helicobacter pylori eradication on body mass index and dyspeptic symptoms.
abstract: OBJECTIVE
  The relationship between Helicobacter pylori infection and body mass index (BMI) and dyspeptic symptoms is controversial. We investigated the changes in BMI and dyspeptic symptoms after H. pylori eradication among stages of atrophic gastritis classified according to the serum pepsinogen (PG) I/II ratio.
  
  
  METHODS
  One hundred and sixty-three H. pylori-positive patients underwent eradication therapy for H. pylori. Serum PG I and II concentrations were measured before treatment, and the PG I/II ratio was classified into three groups: PG I/II ratio <2.0, PG I/II ratio >or=2.0 and <4.0, and PG I/II ratio >or=4.0 were considered to be low, middle, and high, respectively. Their BMI and abdominal symptoms were checked before, 1 and 5 years after treatment, and these changes were investigated among the three groups.
  
  
  RESULTS
  The mean BMI changes 1 year after treatment in the low PG I/II ratio group were significantly higher than those in other groups. Most abdominal symptoms in the high PG I/II ratio group were most severe before eradication but improved significantly after eradication.
  
  
  CONCLUSIONS
  The effects of H. pylori eradication on BMI and dyspeptic symptoms may be different according to the serum PG I/II ratio before eradication.
authors.affiliation: Department of Endoscopic Medicine, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui, Japan. hrykstu@u-fukui.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suto
authors.forename: Yukinao
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Ikumi
authors.initials: I
authors.lastname: Yoshida
authors.forename: Akiyo
authors.initials: A
authors.lastname: Yamakawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ohtani
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ito
authors.forename: Masaru
authors.initials: M
authors.lastname: Kuriyama
authors.forename: Takuji
authors.initials: T
authors.lastname: Kato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Azuma
mesh_terms: D000328:Adult; D015992:Body Mass Index; D004415:Dyspepsia / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005757:Gastritis, Atrophic / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood
chemical_list: D010435:Pepsinogens