title: Ovulation induction using low-dose step-up rFSH in Vietnamese women with polycystic ovary syndrome.
abstract: The aim of this study was to assess the effectiveness and safety of a low-dose step-up protocol with a recombinant FSH starting dose of 25 IU for ovulation induction in anovulatory patients with polycystic ovary syndrome (PCOS) and a normal or low body mass index (BMI). In this prospective, non-comparative, open trial, 183 PCOS patients who had three unsuccessful cycles of ovulation induction with clomiphene citrate received recombinant FSH (Puregon((R))) 25 IU/day for 14 days, the dose was then increased by 25 IU every 5 days if there was no follicle of >12 mm diameter (maximum 150 IU/day). Human chorionic gonadotrophin was administered when the lead follicle was >/=18 mm, and intrauterine insemination was performed 36 h later. Duration of stimulation was 15.9 +/- 4.8 days and total FSH dose was 484 +/- 257 IU. A developing follicle was observed in 96.7% of cycles, of which 62.1% had unifollicular development and 15.8% were cancelled due to over-response. The clinical and ongoing pregnancy rates were 35.5% and 33.9%, respectively. There were no multiple pregnancies, and only one case of mild ovarian hyperstimulation syndrome. A low-dose step-up protocol with a recombinant FSH starting dose of 25 IU/day is effective and safe in anovulatory Vietnamese PCOS patients with a low or normal BMI.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Medicine and Pharmacy of Ho Chi Minh City, 217 Hong Bang Street, District 5, Ho Chi Minh City, Vietnam. lanvuong@hcm.fpt.vn
authors.forename: V T N
authors.initials: VT
authors.lastname: Lan
authors.forename: R J
authors.initials: RJ
authors.lastname: Norman
authors.forename: G H
authors.initials: GH
authors.lastname: Nhu
authors.forename: P H
authors.initials: PH
authors.lastname: Tuan
authors.forename: H M
authors.initials: HM
authors.lastname: Tuong
mesh_terms: D000328:Adult; D000858:Anovulation / Q000188:drug therapy* / Q000209:etiology; D015992:Body Mass Index; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D007315:Insemination, Artificial; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014744:Vietnam
chemical_list: D005640:Follicle Stimulating Hormone