title: The prevalence of 6 weeks postpartum abnormal glucose tolerance in Caucasian women with gestational diabetes.
abstract: OBJECTIVE
  To evaluate the incidence of impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and diabetes in 318 Caucasian women with gestational diabetes (GDM) at 6 weeks postpartum.
  
  
  METHODS
  All women had 75g OGTT and the following data were collected: age, height, weight, results of the challenge 50g and diagnostic 75g OGTT, and glycated hemoglobin (HbA1c).
  
  
  RESULTS
  13.5% of women had abnormal glucose tolerance, including 1.3% of diabetes, 2.5% of IFG and 7.5% of IGT. None of the prepregnancy independent variables, such as age, body mass index, prior GDM, prior macrosomia, family history of type 2 diabetes and multiparity was a predictor for the abnormal OGTT. In contrast, pregnancy-related risk factors, like gestational week at GDM diagnosis (P=0.001), glucose values in the challenge (P=0.007) and diagnostic (P=0.02) OGTTs and HbA1c (P=0.01) were significantly associated with the persistence of glucose intolerance after delivery.
  
  
  CONCLUSIONS
  The incidence of postpartum abnormal glucose tolerance in Caucasian women with GDM was 13.5% and was associated with an early diagnosis of GDM, severity of hyperglycemia and requirement for insulin therapy. The diagnosis of GDM should initiate a lifelong monitoring of glucose tolerance to minimize the risk of developing overt diabetes.
authors.affiliation: Department of Hypertension and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Ogonowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Miazgowski
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D016640:Diabetes, Gestational / Q000097:blood* / Q000188:drug therapy; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D011247:Pregnancy; D011644:Puerperal Disorders / Q000097:blood* / Q000453:epidemiology; D044465:White People
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin