[Expression of metanephric differentiation markers in human mesenchymal stem cells].
Stem cells are a potential source for the regeneration of many tissues, including damaged kidneys. The present study describes the adoption of hyaluronic- butyric acid monoesters (HB) to induce expression of nephrogenic genes by mesenchymal cells isolated from human placental membranes. HB at a concentration of 1 mg/mL induces chromatin opening and increases the expression of the observed markers (cadherin 11, CD24, RAR-alpha, stearoyl-CoA desaturase 2, 14-3-3 0, Ewing sarcoma homolog.). These results open new routes toward cell regeneration after kidney injury.
Bianchi
F
F
Istituto di Nefrologia, Dialisi e Trapianto Renale, Ospedale S. Orsola, Istituto di Cardiologia-INBB, Universita' degli Studi, Bologna 40138, Italy. francib@alice.it
La Manna
G
G
Cantoni
S
S
Cavallini
C
C
Scolari
Mp
M
Ventura
C
C
Stefoni
S
S
D000943:Antigens, Differentiation / Q000378:metabolism; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000293:injuries* / Q000378:metabolism* / Q000601:surgery; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D010920:Placenta; D011247:Pregnancy; D013230:Stearoyl-CoA Desaturase / Q000378:metabolism
D000943:Antigens, Differentiation; D013230:Stearoyl-CoA Desaturase