Respiratory modulation in response to high-frequency airway occlusion delivered during inspiration or expiration.
To investigate whether 30 breaths performed against a high-frequency airway occlusion stimulus modulates ventilatory control both within-phase (within the phase of breathing that the stimulus was presented) and opposite-phase (in the opposite-phase of breathing to that in which the stimulus was presented) of the respiratory cycle. Ten healthy subjects (3 female, 7 male; 22-44 years old) completed 30 breaths prior to and following 30 inspirations or expirations against a high-frequency occlusion stimulus (youbreathe, Exoscience Ltd., London, UK), pressure-matched resistive loading or resting tidal breathing (no load) presented in a random order. The major findings from this study were that inspiratory-only high-frequency occlusion caused a significant augmentation in peak inspiratory airflow and shortening of expiratory time not observed during corresponding resistance. There were no residual effects of any intervention upon any measured ventilatory variables. High-frequency airway occlusion modulates ventilation both within-phase and in the opposite-phase, effects which are absent following resistive loaded breathing.
Sumners
David Paul
DP
Faculty of Engineering, Science and the Built Environment, Sport and Exercise Science Research Centre, London South Bank University, London SE1 0AA, UK. sumnerdp@lsbu.ac.uk
Hunter
Steven P
SP
Green
David A
DA
D000328:Adult; D000403:Airway Resistance / Q000502:physiology*; D045853:Exhalation / Q000502:physiology; D005260:Female; D006801:Humans; D001239:Inhalation / Q000502:physiology; D008297:Male; D011312:Pressure; D012123:Pulmonary Ventilation / Q000502:physiology; D012119:Respiration; D015656:Respiratory Mechanics / Q000502:physiology*; D014732:Vibration; D055815:Young Adult