Targeting of mRNAs to their sites of unconventional splicing in the unfolded protein response.
In this issue of Molecular Cell (Yanagitani et al., 2009) and recently published in Nature (Aragon et al., 2009) are reports on the importance of mRNA localization for unconventional splicing in the unfolded protein response, but the two papers suggest very different mechanisms in mammals and yeast.
Ron
David
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Skirball Institute, NYU School of Medicine, New York, NY 10016, USA.
D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D050356:Lipid Metabolism; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D008957:Models, Genetic; D017510:Protein Folding; D012326:RNA Splicing; D034443:RNA Transport / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism*; D000071701:Regulatory Factor X Transcription Factors; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D013045:Species Specificity; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; C091341:HAC1 protein, S cerevisiae; D008563:Membrane Lipids; D012333:RNA, Messenger; D000071701:Regulatory Factor X Transcription Factors; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors