[Bone fracture and the healing mechanisms. The effects of anti-resorptive agents on fracture healing].
The effects of anti-resorptive agents on fracture healing were reviewed based on the results of our studies using rats and cynomolugus monkeys. Anti-resorptive agents delay natural fracture healing process due to suppressed callus remodeling in response to the extent of remodeling suppression although they never interfere bone union or strength of fracture site. Bisphosphonates can increase the strength of fracture site by dramatically increasing callus volume, however they delay callus remodeling of woven bone into lamellar bone, which is structurally and mechanically superior to woven bone. This suggests that delayed natural fracture healing process caused by bisphosphonates was compensated by increased callus volume of immature bone.
Mashiba
Tasuku
T
Department of Orthopedic Surgery, Kagawa University Faculty of Medicine.
Mori
Satoshi
S
D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D016723:Bone Remodeling / Q000187:drug effects; D002146:Bony Callus / Q000378:metabolism; D004164:Diphosphonates / Q000494:pharmacology* / Q000627:therapeutic use*; D017102:Fracture Healing / Q000187:drug effects; D006801:Humans; D008252:Macaca fascicularis; D051381:Rats
D050071:Bone Density Conservation Agents; D004164:Diphosphonates