Synthesis and characterisation of enhanced barrier polyurethane for encapsulation of implantable medical devices.
Polymeric membranes have been used as interfaces between implantable devices and biological tissues to operate as a protective barrier from water exchanging and to enhance biocompatibility. Polyurethanes have been used as biocompatible membranes for decades. In this study, copolymers of polyether urethane (PEU) with polydimethylsiloxane (PDMS) were synthesised with the goal of creating materials with low water permeability and high elasticity. PDMS was incorporated into polymer backbone as a part of the soft segment during polyurethane synthesis and physical properties as well as water permeability of resulting copolymer were studied in regard to PDMS content. Increase in PDMS content led to increase of microphase separation of the copolymer and corresponding increase in elastic modulus. Surface energy of the polymer was decreased by incorporating PDMS compared to unmodified PEU. PDMS in copolymer formed a hydrophobic surface which caused reduction in water permeability and water uptake of the membranes. Thus, PDMS containing polyurethane with its potent water resistant properties demonstrated a great promise for use as an implantable encapsulation material.
Roohpour
Nima
N
Interdisciplinary Research Centre in Biomedical Materials, School of Engineering and Material Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Wasikiewicz
Jaroslaw M
JM
Paul
Deepen
D
Vadgama
Pankaj
P
Rehman
Ihtesham U
IU
D002152:Calorimetry, Differential Scanning / Q000379:methods; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D004548:Elasticity; D057927:Hydrophobic and Hydrophilic Interactions; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D011108:Polymers / Q000737:chemistry; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry*; D019736:Prostheses and Implants; D012542:Scattering, Radiation; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman / Q000379:methods; D013314:Stress, Mechanical; D013718:Tensile Strength; D014867:Water / Q000737:chemistry
D004129:Dimethylpolysiloxanes; D011108:Polymers; D011140:Polyurethanes; D014867:Water; C013830:baysilon