Microbial transformation of 18beta-glycyrrhetinic acid by Cunninghamella elegans and Fusarium lini, and lipoxygenase inhibitory activity of transformed products.
The microbial transformation of 18beta-glycyrrhetinic acid (1) by Cunninghamella elegans afforded a metabolite, 3beta,7beta-dihydroxy-11-oxo-olean-12-en-30-oic acid (2), while fermentation of 1 with Fusarium lini afforded a metabolite, 3,11-dioxo-olean-12-en-30-oic acid (3). Compound 3 exhibited a potent lipoxygenase (LOX) inhibitory activity. The structures of these metabolites were elucidated on the basis of spectroscopic techniques.
Iqbal Choudhary
Muhammad
M
International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
Ali Siddiqui
Zafar
Z
Ahmed Nawaz
Sarfraz
S
D020093:Cunninghamella / Q000378:metabolism*; D005285:Fermentation; D005670:Fusarium / Q000378:metabolism*; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000378:metabolism*; D015394:Molecular Structure
D016859:Lipoxygenase Inhibitors; C119129:18alpha-glycyrrhetinic acid; D006034:Glycyrrhetinic Acid