title: F(2)-isoprostanes, tocopherols and normal pregnancy.
abstract: This study investigates oxidative stress and antioxidants in normal human pregnancy and post-partum period. Thirty-seven healthy women with normal pregnancies were included. Both urinary and serum samples were collected throughout the pregnancy and post-partum period. Oxidative stress was estimated by measuring the reliable in vivo marker, namely 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha,) an F(2)-isoprostane) and antioxidant status was evaluated by measuring alpha- and gamma-tocopherol in serum samples. Pregnancy was associated with successively increased levels of 8-iso-PGF(2alpha) with advancing gestational age. The median post-partum value corresponded to the values observed in early gestation and a significant decrease was observed from late pregnancy to the post-partum period. Lipid-adjusted alpha- and gamma-tocopherol levels decreased with advancing gestational age. This longitudinal study suggests that mild oxidative stress is involved in normal human pregnancy.
authors.affiliation: Department of Women's and Children's Health, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Palm
authors.forename: Ove
authors.initials: O
authors.lastname: Axelsson
authors.forename: Lisa
authors.initials: L
authors.lastname: Wernroth
authors.forename: Samar
authors.initials: S
authors.lastname: Basu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000032:analysis; D005260:Female; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D011247:Pregnancy / Q000097:blood* / Q000652:urine*; D011863:Radioimmunoassay; D024502:alpha-Tocopherol / Q000032:analysis*
chemical_list: D015415:Biomarkers; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D024502:alpha-Tocopherol