title: Sitafloxacin activity against Helicobacter pylori isolates, including those with gyrA mutations.
abstract: Sitafloxacin showed MICs of less than or equal to 0.5 microg/ml against 105 isolates of Helicobacter pylori, including 44 isolates with mutations in the gyrA gene. The highest MICs for garenoxacin and levofloxacin were 8 and 64 times, respectively, higher than the highest MICs observed for sitafloxacin.
authors.affiliation: Toho University School of Medicine, 4-16-20 Omori-nishi, Ota-ku, Tokyo, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Murakami
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Okimoto
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kodama
authors.forename: Jin
authors.initials: J
authors.lastname: Tanahashi
authors.forename: Toshio
authors.initials: T
authors.lastname: Fujioka
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Ikeda
authors.forename: Hiroe
authors.initials: H
authors.lastname: Muraoka
authors.forename: Motoko
authors.initials: M
authors.lastname: Takigawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Saika
authors.forename: Miyuki
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Intetsu
authors.initials: I
authors.lastname: Kobayashi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics*; D024841:Fluoroquinolones / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics*; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D009154:Mutation; D015242:Ofloxacin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D064704:Levofloxacin; C076246:sitafloxacin; D015242:Ofloxacin; D027081:DNA Gyrase; C419689:garenoxacin