Coated-platelet levels are low in patients with spontaneous intracerebral hemorrhage.
OBJECTIVE
Coated-platelets are a subset of platelets with high procoagulant potential observed on dual agonist stimulation with collagen and thrombin. Failure to produce coated-platelets in animals results in a bleeding diathesis. With this background, we undertook a pilot study to investigate coated-platelet production in patients with spontaneous intracerebral hemorrhage (SICH).


METHODS
Coated-platelet levels were determined in 26 patients with a diagnosis of SICH and 52 controls.


RESULTS
The patient population had significantly lower coated-platelet levels than the controls (mean+/-SD, 24.8+/-9.7% versus 32.9+/-12.6%, P=0.0035).


CONCLUSIONS
Decreased coated-platelet synthesis may be linked to the mechanisms involved in the events leading to SICH.
Prodan
Calin I
CI
Department of Neurology, University of Oklahoma Health Sciences Center, University of Oklahoma, Oklahoma City, OK 73104, USA. calin-prodan@ouhsc.edu
Vincent
Andrea S
AS
Padmanabhan
Rajiv
R
Dale
George L
GL
D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology*; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D003094:Collagen / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D013917:Thrombin / Q000494:pharmacology
D003094:Collagen; D013917:Thrombin