A novel codon insert in protease of clade B HIV type 1.
A novel combination of three codon inserts in the pol coding region of HIV-1 RNA was identified in a highly antiretroviral experienced study subject with HIV-1 infection. A one codon insert was observed in the protease region between codon 40 and 41 simultaneously with a two codon insert present in the reverse transcriptase region at codon 69.
Jordan
Parris S
PS
University of California, San Diego, La Jolla, California 92093, USA.
Poon
Art
A
Eron
Joseph
J
Squires
Kathleen
K
Ignacio
Caroline
C
Richman
Douglas D
DD
Smith
Davey M
DM
D001483:Base Sequence; D015658:HIV Infections / Q000821:virology*; D016333:HIV Protease / Q000235:genetics*; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA
D012367:RNA, Viral; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase; D016333:HIV Protease; C514803:p16 protease, Human immunodeficiency virus 1