[The role of inhibins in functions and dysfunctions of female reproduction. Part I].
The regulation of reproduction is performed by complex hormonal system: hypothalamus--pituitary--ovary. There are a lot of ovarian peptides, playing an essential role in the regulation of this system. However, the mechanisms of their action are not exactly known. Inhibins are glycoproteins produced mainly in the ovaries and they take part in the regulation of menstrual cycle. They consist of glycosylated alpha subunit and one of two beta subunits, inhibin A and inhibin B. There are studies about possible use of inhibins in reproductive medicine. Recent data indicate the role of inhibin A in obstetrics. The measurement of inhibin B can provide useful information about ovarian reserve, and plays an important role in assisted reproductive techniques. Inhibin B can be also regarded as potential marker of diagnosis of premature ovarian failure (POF) and ovarian recovery in hypothalamic disturbances. Both inhibin A and inhibin B can play helpful role in the assessment of ovarian function in patient with Turner syndrome. The estimation of total inhibin levels in blood serum seems to be advantageous in the diagnosis of patients with polycystic ovary syndrome (PCOS) and ovarian tumors. There are requirements of further studies to clarify the use of inhibins in clinical practice of reproductive endocrinology.
Meczekalski
Błazej
B
Department of Gynecological Endocrinology, University of Medical Sciences in Poznan, Poland. blazejmeczekalski@yahoo.com
Podfigurna-Stopa
Agnieszka
A
D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006801:Humans; D007265:Inhibins / Q000378:metabolism*; D008597:Menstrual Cycle / Q000502:physiology; D010049:Ovarian Diseases / Q000175:diagnosis / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology*; D014424:Turner Syndrome / Q000378:metabolism
D015415:Biomarkers; C422362:inhibin A; C422364:inhibin B; D007265:Inhibins