title: Enantioselective Robinson-type annulation reaction catalyzed by chiral phosphoric acids.
abstract: Let's resolve our differences: Implementation of an enantioselective Michael addition followed by an intramolecular aldol reaction catalyzed by two phosphoric acids has enabled the synthesis of cyclohexenone derivatives with excellent enantioselectivities. Prominent kinetic resolution was observed in the latter reaction. Ar = aromatic group, X = H, halogen, Y = H, Me, halogen.
authors.affiliation: Department of Chemistry, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo 171-8588, Japan. takahiko.akiyama@gakushuin.ac.jp
authors.forename: Takahiko
authors.initials: T
authors.lastname: Akiyama
authors.forename: Takuya
authors.initials: T
authors.lastname: Katoh
authors.forename: Keiji
authors.initials: K
authors.lastname: Mori
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D003512:Cyclohexanones / Q000138:chemical synthesis*; D010756:Phosphoric Acids / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D003512:Cyclohexanones; D010756:Phosphoric Acids; C116609:3-hydroxybutanal