title: Cutaneous infection caused by Macrophomina phaseolina in a child with acute myeloid leukemia.
abstract: We report a case of Macrophomina phaseolina skin infection in an immunocompromised child with acute myeloid leukemia, which was treated successfully with posaconazole without recurrence after a hematopoietic stem cell transplant. The fungus was identified by DNA sequencing using both the internal transcribed spacer and D1/D2 region of the 28S ribosomal DNA gene.
authors.affiliation: Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 260, Memphis, TN 38105, USA. ashok.srinivasan@stjude.org
authors.forename: Ashok
authors.initials: A
authors.lastname: Srinivasan
authors.forename: Brian L
authors.initials: BL
authors.lastname: Wickes
authors.forename: Anna M
authors.initials: AM
authors.lastname: Romanelli
authors.forename: Larisa
authors.initials: L
authors.lastname: Debelenko
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Rubnitz
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Thompson
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: Randall T
authors.initials: RT
authors.lastname: Hayden
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Shenep
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001203:Ascomycota / Q000302:isolation & purification*; D002648:Child; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003881:Dermatomycoses / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012867:Skin / Q000473:pathology; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D014230:Triazoles; C101425:posaconazole