title: Cerebral arteriovenous malformations. Part 2: physiology.
abstract: OBJECTIVE
  The scientific understanding of the nature of arteriovenous malformations (AVMs) in the brain is evolving. It is clear from current work that AVMs can undergo a variety of phenomena, including growth, remodeling, and/or regression-and the responsible processes are both molecular and physiological. A review of these complex processes is critical to directing future therapeutic approaches. The authors performed a comprehensive review of the literature to evaluate current information regarding the genetics, pathophysiology, and behavior of AVMs.
  
  
  METHODS
  A comprehensive literature review was conducted using PubMed to reveal the angioarchitecture and cerebral hemodynamics of AVMS as they relate to lesion development.
  
  
  RESULTS
  Feeding artery pressures, brain AVM compartmentalization, venous drainage, flow phenomena, and vascular steal are discussed.
  
  
  CONCLUSIONS
  The dynamic nature of brain AVMs is at least in part attributable to hemodynamic and flow-related phenomena. These forces acting on an evolving structure are critical to understanding the challenges in endovascular and surgical therapy. As knowledge in this field continues to progress, the natural history and predicted behavior of these AVMs will become more clearly elucidated.
authors.affiliation: Department of Neurosurgery, Cedars Sinai Medical Center, University of California, Los Angeles, California 90095, USA.
authors.forename: Parham
authors.initials: P
authors.lastname: Moftakhar
authors.forename: Jason S
authors.initials: JS
authors.lastname: Hauptman
authors.forename: Dennis
authors.initials: D
authors.lastname: Malkasian
authors.forename: Neil A
authors.initials: NA
authors.lastname: Martin
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D002196:Capillaries / Q000473:pathology / Q000503:physiopathology; D002536:Cerebral Arteries / Q000002:abnormalities* / Q000378:metabolism / Q000503:physiopathology*; D002550:Cerebral Veins / Q000002:abnormalities* / Q000378:metabolism / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000235:genetics*; D006439:Hemodynamics / Q000235:genetics; D006801:Humans; D002532:Intracranial Aneurysm / Q000209:etiology / Q000503:physiopathology; D002538:Intracranial Arteriovenous Malformations / Q000150:complications / Q000235:genetics / Q000503:physiopathology*