Efficient and green synthesis of tetrasubstituted pyrroles promoted by task-specific basic ionic liquids as catalyst in aqueous media.
Synthesis of tetrasubstituted pyrroles by the three-component condensation reaction of acid chlorides, dialkyl acetylenedicarboxylates, and amino acids in the presence of various room-temperature ionic liquids (RTILs) as catalysts in water is reported. Among the ionic liquids used, the basic functionalized ionic liquid, butyl methyl imidazolium hydroxide [bmim]OH, was the most effective catalyst. The influence of reaction temperature, reaction time, and amount of ionic liquid on the reaction was investigated. The [bmim]OH/H(2)O catalyst system could be reused for at least five recycles without appreciable loss of efficiency.
Yavari
Issa
I
Chemistry Department, Tarbiat Modares University, Tehran, Iran. yavarisa@modares.ac.ir
Kowsari
Elaheh
E
D002384:Catalysis; D055772:Green Chemistry Technology / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D052578:Ionic Liquids / Q000737:chemistry*; D007700:Kinetics; D011758:Pyrroles / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry*
D052578:Ionic Liquids; D011758:Pyrroles; D012997:Solvents; D014867:Water