title: Novel action of 7-O-galloyl-D-sedoheptulose isolated from Corni Fructus as a hypertriglyceridaemic agent.
abstract: OBJECTIVE
  We investigated the lipid-lowering activity of 7-O-galloyl-D-sedoheptulose, an active component of Corni Fructus, and related mechanisms.
  
  
  METHODS
  Rats were fed a high-fructose diet for 6 days, followed by treatment with 7-O-galloyl-D-sedoheptulose, 5, 10 or 20 mg/kg per day, or fenofibrate (positive control).
  
  
  RESULTS
  The high-fructose diet induced an increase in body weight, hypertriglyceridaemia, hyperglycaemia and hypertension. Administration of 7-O-galloyl-D-sedoheptulose significantly reduced the levels of triglyceride in the serum and liver (being more effective than fenofibrate) but did not lead to changes in liver weight or hepatic function, whereas fenofibrate increased the liver weight markedly. The preventive effect of 7-O-galloyl-D-sedoheptulose against the accumulation of triglyceride and cholesterol was related to the up-regulation of peroxisome proliferator-activated receptor alpha expression.
  
  
  CONCLUSIONS
  The present study supports the role of 7-O-galloyl-D-sedoheptulose as a promising agent against hypertriglyceridaemia without hepatic side-effects.
authors.affiliation: Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan. yokozawa@inm.u-toyama.ac.jp
authors.forename: Takako
authors.initials: T
authors.lastname: Yokozawa
authors.forename: Chan Hum
authors.initials: CH
authors.lastname: Park
authors.forename: Jeong Sook
authors.initials: JS
authors.lastname: Noh
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Cho
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D029768:Cornus / Q000737:chemistry*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005632:Fructose / Q000008:administration & dosage; D006539:Heptoses / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism; D008297:Male; D047493:PPAR alpha / Q000378:metabolism; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: C540464:7-O-galloyl-D-sedoheptulose; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006539:Heptoses; D000960:Hypolipidemic Agents; D047493:PPAR alpha; D010936:Plant Extracts; D014280:Triglycerides; D005632:Fructose; D002784:Cholesterol