title: Rapid identification of improved protein ligands using peptoid microarrays.
abstract: A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.
authors.affiliation: Department of Internal Medicine, Division of Translational Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9185, USA.
authors.forename: Hyun-Suk
authors.initials: HS
authors.lastname: Lim
authors.forename: M Muralidhar
authors.initials: MM
authors.lastname: Reddy
authors.forename: Xiangshu
authors.initials: X
authors.lastname: Xiao
authors.forename: Johnnie
authors.initials: J
authors.lastname: Wilson
authors.forename: Rosemary
authors.initials: R
authors.lastname: Wilson
authors.forename: Steven
authors.initials: S
authors.lastname: Connell
authors.forename: Thomas
authors.initials: T
authors.lastname: Kodadek
mesh_terms: D008024:Ligands; D034444:Peptoids / Q000138:chemical synthesis / Q000737:chemistry*; D040081:Protein Array Analysis; D011506:Proteins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D008024:Ligands; D034444:Peptoids; D011506:Proteins