Drug/dye-loaded, multifunctional iron oxide nanoparticles for combined targeted cancer therapy and dual optical/magnetic resonance imaging.
A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate-expressing cancer cells.
Santra
Santimukul
S
Nanoscience Technology Center, Chemistry Department Burnett School of Biomedical Sciences, College of Medicine University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA.
Kaittanis
Charalambos
C
Grimm
Jan
J
Perez
J Manuel
JM
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004058:Diffusion; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000494:pharmacology*; D005492:Folic Acid / Q000737:chemistry; D006801:Humans; D008024:Ligands; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D055095:Optics and Photonics; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared / Q000379:methods
D000970:Antineoplastic Agents; D005290:Ferric Compounds; D005456:Fluorescent Dyes; D008024:Ligands; D012997:Solvents; C000499:ferric oxide; D005492:Folic Acid