Antimalarial and cytotoxic phenolic compounds from Cratoxylum maingayi and Cratoxylum cochinchinense.
Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC(50) of 0.22 microg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC(50) of 0.66 microg/mL.
Laphookhieo
Surat
S
School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand. surat@mfu.ac.th
Maneerat
Wisanu
W
Koysomboon
Sorwaporn
S
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D028084:Clusiaceae / Q000033:anatomy & histology / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D055752:Small Cell Lung Carcinoma
D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D010636:Phenols; D010936:Plant Extracts