Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis.
To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.
Cacere
Camila R
CR
Laboratory of Dermatology and Immunodeficiencies, Medical School of the University of São Paulo, São Paulo, Brazil.
Mendes-Giannini
Maria J S
MJ
do Valle
Antonio Carlos F
AC
Duarte
Alberto J S
AJ
Benard
Gil
G
D000328:Adult; D000368:Aged; D053181:Caspase 8 / Q000096:biosynthesis*; D053453:Caspase 9 / Q000096:biosynthesis*; D006801:Humans; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000276:immunology; D008875:Middle Aged; D010229:Paracoccidioidomycosis / Q000276:immunology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000276:immunology*; D055815:Young Adult
D007376:Interleukin-2; D019253:Proto-Oncogene Proteins c-bcl-2; C505530:CASP8 protein, human; D053181:Caspase 8; D053453:Caspase 9