Low-molecular-weight dendrons for DNA binding and release by reduction-triggered degradation of multivalent interactions.
Losing the grip: The synthesis of multivalent low-molecular-weight dendrons with lysine branching units coupled to disulfide-linked spermine surface groups is described. It is furthermore demonstrated that the dendrons bind DNA with good affinity (see image), but are also able to release the DNA in a reductive environment.
Kostiainen
Mauri A
MA
Department of Engineering Physics, Helsinki University of Technology, P.O. BOX 2200, 02015 HUT, Espoo, Finland. m.kostiainen@science.ru.nl
Rosilo
Henna
H
D004247:DNA / Q000737:chemistry*; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008239:Lysine / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008970:Molecular Weight; D013096:Spermine / Q000737:chemistry
D050091:Dendrimers; D013096:Spermine; D004247:DNA; D008239:Lysine