Synthesis of gamma-nitro aliphatic methyl esters via Michael additions promoted by microwave irradiation.
A simple and efficient protocol has been developed for the direct synthesis of gamma-nitrobutyric acid methyl esters under microwave irradiation. This methodology reduces reaction times from days to minutes, compared to conventional conditions. Additionally, these conditions increased yields and provided cleaner reactions.
Escalante
Jaime
J
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos. Cuernavaca, Mor., Mexico. jaime@ciq.uaem.mx
Díaz-Coutiño
Francisco D
FD
D002087:Butyrates / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure
D002087:Butyrates; D004952:Esters