[Biology of arterial ageing and arteriosclerosis].
Arterial ageing - arteriosclerosis - is characterised by both thickening and stiffening of the walls of large and medium arteries. The molecular and cellular mechanisms (i.e. endothelial dysfunction, matrix remodelling, ...) involved in this process are complex, and at least in part common to atherosclerotic injury. Arterial stiffness is strongly associated with cardiovascular disease and an increased risk of morbidity and mortality. The aim of this review is to provide an update on the pathophysiology and the biological process of arterial ageing and to underline the main difference with atherosclerosis damage process in particularly during the calcification step.
Cottart
Charles-Henry
CH
APHP, Hôpital Charles-Foix, Ivry sur Seine, France. charles-henry.cottart@cfx.aphp.fr
Laguillier
Christelle
C
Nivet-Antoine
Valérie
V
Klimczak
Christophe
C
Sebban
Claude
C
Beaudeux
Jean-Louis
JL
D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D001120:Arginine / Q000031:analogs & derivatives / Q000378:metabolism; D001161:Arteriosclerosis / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D050197:Atherosclerosis / Q000503:physiopathology; D002114:Calcinosis / Q000503:physiopathology; D003935:Diagnostic Techniques, Cardiovascular; D004730:Endothelium, Vascular / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology; D010006:Osteoblasts / Q000502:physiology; D017540:Tunica Media / Q000473:pathology; D014655:Vascular Resistance
D008074:Lipoproteins; C018524:N,N-dimethylarginine; D001120:Arginine