Histopathology of Hodgkin's lymphoma.
In the last few years, there has been a greater understanding of the spectrum and biology of Hodgkin's lymphoma. In standard texts, Hodgkin's lymphoma is classified as 2 distinct entities, namely nodular lymphocyte predominant Hodgkin's lymphoma and classical Hodgkin's lymphoma. However, recent evidence suggests that classical Hodgkin's lymphoma is not a single disease. Although the mixed cellularity and lymphocyte-depleted subtypes may be part of a biologic continuum, the nodular sclerosis subtype has a distinct epidemiology, clinical presentation, and histology. Nodular sclerosis Hodgkin's lymphoma, particularly those cases presenting with mediastinal disease, also seems related to primary mediastinal B-cell lymphoma. As Hodgkin's lymphoma is a B-cell neoplasm, there is also a better appreciation today of cases that may be borderline with conventional B-cell lymphomas. We present an update on the histopathological features of Hodgkin's lymphoma and the immunohistochemical tools available for diagnosis in the clinical setting.
Eberle
Franziska C
FC
Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mani
Haresh
H
Jaffe
Elaine S
ES
D049672:History, 19th Century; D049673:History, 20th Century; D006689:Hodgkin Disease / Q000145:classification / Q000266:history / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000145:classification / Q000266:history / Q000473:pathology