Indium-catalyzed reductive alkylation of pyrroles with alkynes and hydrosilanes: selective synthesis of beta-alkylpyrroles.
Mixing readily available alkynes, pyrroles, and triethylsilane along with an indium catalyst was found to be an efficient procedure to introduce alkyl groups onto a beta-position of pyrroles in a complete regioselective manner. This is the first demonstration of catalytic beta-alkylation of pyrroles in a single step.
Tsuchimoto
Teruhisa
T
Department of Applied Chemistry, School of Science and Technology, Meiji University, Higashimita, Tama-ku, Kawasaki 214-8571, Japan. tsuchimo@isc.meiji.ac.jp
Wagatsuma
Tatsuya
T
Aoki
Kazuki
K
Shimotori
Jun
J
D000478:Alkylation; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007204:Indium / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D011758:Pyrroles; D012821:Silanes; D007204:Indium