The detection of Bovine Papillomavirus type 1 DNA in flies.
BPVs are double stranded DNA viruses that can infect several species other than the natural host, cattle, including equids. In equids, BPV-1, and, less commonly BPV-2, infection gives rise to fibroblastic tumours of the skin. Whilst a causal relationship between BPV-1/2 and equine sarcoids is now well established, how the disease is transmitted is not known. In this study we show BPV-1 DNA can be detected in flies trapped in the proximity of sarcoid-affected animals. Sequence analysis of the BPV-1 LCR from flies indicates that flies harbour BPV-1 LCR sequence variants II and IV which are commonly detected in equine sarcoids. These data suggest that flies may be able to transmit BPV-1 between equids.
Finlay
Margaret
M
Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK.
Yuan
ZhengQiang
Z
Burden
Faith
F
Trawford
Andrew
A
Morgan
Iain M
IM
Campo
M Saveria
MS
Nasir
Lubna
L
D000818:Animals; D052688:Bovine papillomavirus 1 / Q000302:isolation & purification*; D004279:DNA, Viral / Q000235:genetics; D004175:Diptera / Q000821:virology*; D004199:Disease Vectors; D006734:Horse Diseases / Q000635:transmission / Q000821:virology*; D006736:Horses; D006799:Housing, Animal; D017422:Sequence Analysis, DNA; D017193:Skin Diseases, Viral / Q000635:transmission / Q000662:veterinary*
D004279:DNA, Viral