"On-off" multivalent recognition: degradable dendrons for temporary high-affinity DNA binding.
Now you bind it--now you don't! Chemical degradation of a dendritic scaffold allows multivalent interactions with DNA to be "switched off" as the multivalent array of ligands breaks down into smaller fragments, offering an approach by which a molecule can be temporarily endowed with high affinity for a biological target--an important concept in the development of new synthetic systems to intervene in biological pathways.
Welsh
Daniel J
DJ
Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
Jones
Simon P
SP
Smith
David K
DK
D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*
D050091:Dendrimers; D004247:DNA; C427203:calf thymus DNA