Kounis syndrome in a patient with ovarian cancer and allergy to iodinated contrast media: report of a case of vasospastic angina induced by chemotherapy.
We report the case of a 71-year-old woman with previous coronary angioplasty, ovarian cancer with multiple metastases and allergy to iodinated contrast media, who developed vasospastic angina after several treatments with cisplatin and cyclophosphamide, so that we considered this as a case of "allergic angina" or Kounis syndrome (type II variant). The patient underwent standard anti-ischemic therapy with nitrates, calcium blocking agents and enoxaparin so having an uneventful outcome.
Oneglia
Carlo
C
Cardiology Unit, Ospedale "S.Orsola" Fatebenefratelli, via V. Emanuele II, 27, 25122, Brescia, Italy. Electronic address: carlo.oneglia@tele2.it.
Kounis
Nicholas G
NG
Medical Sciences, School of Health Sciences, Patras Highest Institute of Education and Technology, 7 Aratou Street, Queen Olgas Square, Patras 26221, Greece.
Beretta
Giordano
G
Oncology Unit, Ospedale "S.Orsola" Fatebenefratelli, via V. Emanuele II, 27, 25122, Brescia, Italy.
Ghizzoni
Giuseppe
G
Cardiology Unit, Ospedale "S.Orsola" Fatebenefratelli, via V. Emanuele II, 27, 25122, Brescia, Italy.
Gualeni
Anna
A
Cardiology Unit, Ospedale "S.Orsola" Fatebenefratelli, via V. Emanuele II, 27, 25122, Brescia, Italy.
Berti
Marco
M
Cardiology Unit, Ospedale "S.Orsola" Fatebenefratelli, via V. Emanuele II, 27, 25122, Brescia, Italy.
D000368:Aged; D000788:Angina Pectoris, Variant / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003287:Contrast Media / Q000009:adverse effects*; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000503:physiopathology; D017613:Iodine Compounds / Q000009:adverse effects; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy*; D013577:Syndrome
D000970:Antineoplastic Agents; D003287:Contrast Media; D017613:Iodine Compounds