title: Quantitative characterization of solid epoxy resins using comprehensive two dimensional liquid chromatography coupled with electrospray ionization-time of flight mass spectrometry.
abstract: A comprehensive multidimensional liquid chromatography system coupled to Electrospray Ionization-Mass Spectrometry (LCxLC-ESI-MS) was developed for detailed characterization and quantitation of solid epoxy resin components. The two orthogonal modes of separation selected were size exclusion chromatography (SEC) in the first dimension and liquid chromatography at critical conditions (LCCC) in the second dimension. Different components present in the solid epoxy resins were separated and quantitated for the first time based on the functional groups and molecular weight heterogeneity. Coupling LCxLC separations with mass spectrometry enabled the identification of components resolved in the two-dimensional space. Several different functional group families of compounds were separated and identified, including epoxy-epoxy and epoxy-alpha-glycol functional oligomers, and their individual molecular weight ranges were determined. Repeatability obtained ranged from 0.5% for the main product to 21% for oligomers at the 0.4% concentration level.
authors.affiliation: The Dow Chemical Company, Analytical Sciences, 1897 Building, Midland, Michigan 48667, USA.
authors.forename: Samir
authors.initials: S
authors.lastname: Julka
authors.forename: Hernan
authors.initials: H
authors.lastname: Cortes
authors.forename: Robert
authors.initials: R
authors.lastname: Harfmann
authors.forename: Bruce
authors.initials: B
authors.lastname: Bell
authors.forename: Andreas
authors.initials: A
authors.lastname: Schweizer-Theobaldt
authors.forename: Matthias
authors.initials: M
authors.lastname: Pursch
authors.forename: Luigi
authors.initials: L
authors.lastname: Mondello
authors.forename: Shawn
authors.initials: S
authors.lastname: Maynard
authors.forename: David
authors.initials: D
authors.lastname: West
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D004853:Epoxy Resins / Q000032:analysis* / Q000138:chemical synthesis; D015203:Reproducibility of Results; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D004853:Epoxy Resins