title: A nanocube plasmonic sensor for molecular binding on membrane surfaces.
abstract: Detection and characterization of molecular interactions on membrane surfaces is important to biological and pharmacological research. Here, silver nanocubes interfaced with glass-supported model membranes form a label-free sensor that measures protein binding to the membrane. The technique utilizes plasmon resonance scattering of nanocubes, which are chemically coupled to the membrane. In contrast to other plasmonic sensing techniques, this method features simple, solution-based device fabrication and readout. Static and dynamic protein/membrane binding are monitored and quantified.
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Galush
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Shelby
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Mulvihill
authors.forename: Andrea
authors.initials: A
authors.lastname: Tao
authors.forename: Peidong
authors.initials: P
authors.lastname: Yang
authors.forename: Jay T
authors.initials: JT
authors.lastname: Groves
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D053768:Metal Nanoparticles / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012834:Silver / Q000737:chemistry*; D020349:Surface Plasmon Resonance
chemical_list: D011506:Proteins; D012834:Silver