title: Do single-photon emission computerized tomography findings predict severity of chronic rhinosinusitis: a pilot study.
abstract: BACKGROUND
  Chronic rhinosinusitis (CRS) is basically an inflammatory disease of the mucosa and periosteum of the sinuses. The possibility of local osteitis can cause persistent mucosal inflammation and lead to failure of treatment. Bone scintigraphy is the gold standard procedure for detecting the bone involvement. This study was designed to evaluate whether single-photon emission computerized tomography (SPECT) findings predict severity of chronic sinusitis and subjective response to medical treatment. A prospective case control study was done.
  
  
  METHODS
  Twenty-four patients with CRS were involved. SPECT findings for bone involvement and computed tomography-based staging (limited disease, stage 1; extensive disease, stages 2 and 3) were compared. These data were also analyzed in terms of subjective response to medical treatment and prognosis.
  
  
  RESULTS
  SPECT uptakes were positive in 79.2% (19/24) and negative in 20.8% (5/24) of the patients. SPECT was positive in 4/8 of the patients with limited disease and 15/16 of the patients with extensive disease. In subjective assessment of medical treatment 5/8 of the limited disease versus 1/16 the extensive disease patients had good response; whereas 5/5 of SPECT(-) patients versus 1/19 of SPECT(+) patients had good response.
  
  
  CONCLUSIONS
  Bone SPECT results were found to be correlated with the stage of CRS. Poorer subjective response was observed in patients with positive SPECT.
authors.affiliation: Department of Otorhinolaryngology, Ministry of Health, Ankara Numune Hospital, Ankara, Turkey.
authors.forename: Güleser
authors.initials: G
authors.lastname: Saylam
authors.forename: Orhan
authors.initials: O
authors.lastname: Görgülü
authors.forename: Hakan
authors.initials: H
authors.lastname: Korkmaz
authors.forename: Engin
authors.initials: E
authors.lastname: Dursun
authors.forename: Hülya
authors.initials: H
authors.lastname: Ortapamuk
authors.forename: Adil
authors.initials: A
authors.lastname: Eryilmaz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011859:Radiography; D012220:Rhinitis / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D012720:Severity of Illness Index; D012852:Sinusitis / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome