Design and synthesis of cyclic arodyn analogues by ring-closing metathesis (RCM) for kappa opioid receptor (KOP) antagonists.
Fang
Wei-Jie
WJ
Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA.
Kulkarni
Santosh S
SS
Murray
Thomas F
TF
Aldrich
Jane V
JV
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D015195:Drug Design; D004399:Dynorphins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors*
D017473:Receptors, Opioid, kappa; C470200:arodyn; D004399:Dynorphins