Determination of prooxidant--antioxidant balance after acute coronary syndrome using a rapid assay: a pilot study.
The purpose of the current study was to investigate a novel measure of oxidative stress in patients with acute coronary syndrome (ACS) using a pro-oxidant-antioxidant balance (PAB) assay, which is simple and rapid. Blood samples were taken from 94 patients admitted with ACS. Pro-oxidant-antioxidant balance values were determined in the first and second 12 hours after the onset of symptoms and compared with values for 81 age- and sex-matched controls. The mean PAB values in the first and second 12-hour samples of patients were both significantly higher than that of controls (P < .001). Among patients, PAB values were also significantly higher in the second samples compared with the first samples (P < .001). These findings indicate a heightened state of oxidative stress following ACS and suggest that the PAB value may be considered as a cardiovascular risk predictor to estimate the extent of oxidative stress.
Ghayour-Mobarhan
Majid
M
Cardiovascular Research Center, Avicenna Research Institute, Mashhad University of Medical Science (MUMS), Mashhad, Iran.
Alamdari
Daryoush Hamidi
DH
Moohebati
Mohsen
M
Sahebkar
Amirhossein
A
Nematy
Mohsen
M
Safarian
Mohammad
M
Azimi-Nezhad
Mohsen
M
Parizadeh
Seyyed Mohammad Reza
SM
Tavallaie
Shima
S
Koliakos
George
G
Ferns
Gordon
G
D054058:Acute Coronary Syndrome / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010865:Pilot Projects; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000097:blood*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species