[Interleukin-1 genetic polymorphism: association with gastric cancer in the high-risk Central-Western population of Venezuela].
BACKGROUND
Genetic predisposition may play a role in the prevalence of gastric cancer (GC).


OBJECTIVE
To investigate the relationship between selected interleukin-1 (IL-1) loci polymorphisms and gastric cancer risk in the Central-Western region of Venezuela, where gastric cancer represents the first cause of cancer-related deaths.


METHODS
In a case-control study we compared the frequencies of IL-1B-511 and IL-1B+3954 biallelic polymorphism, and the pentallelic VNTR of IL-IRN in 84 gastric adenocarcinoma paraffin-embedded biopsies and 84 endoscopic biopsies from cancer-free controls.


RESULTS
No significant increase in genotypic frequencies in gastric cancer was observed for any of the IL-1B-511 allelic combinations. However, in a logistic regression analysis, a significant association emerged for the IL-1B+3954C carrier genotype (odds ratio (OR): 6.2; 95% confidence intervals (CI) 1.3-28.8). On the other hand, a significantly higher risk was evidenced for the IL-IRN*2/*2 genotype (OR: 7.0; 95% CI2.3-21.5). Only patients with a well/moderately-differentiated adenocarcinoma that were homozygotes for the E-IRN*2/*2 genotype, had a higher risk than the complete gastric cancer group (OR: 8.1, 95% CI 2.5-26.8). Some genotype combinations among IL-1B-511, IL-1B+3954 and IL-IRN showed an increased risk for developing gastric cancer and well/moderate differentiated adenocarcinoma, that was dependent of the presence of IL-IRN*2/*2 genotype.


CONCLUSIONS
IL-IRN*2/*2 genotype is associated with increased risk of gastric cancer in the Venezuelan population.
Cañas
Miryan
M
Laboratorio de Genética Molecular Dr. Jorge Yunis-Turbay, Decanato de Ciencias de Salud, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Venezuela.
Morán
Yeinmy
Y
Rivero
María Belén
MB
Bohórquez
Adolfo
A
Villegas
Venus
V
Rendón
Yanet
Y
Ramírez
Eddy
E
Valderrama
Elvis
E
Briceño
Zuly
Z
Chiurillo
Miguel Angel
MA
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D014687:Venezuela; D055815:Young Adult
D007375:Interleukin-1