title: Isomer resolution by micelle-assisted diffusion-ordered spectroscopy.
abstract: Diffusion-ordered NMR spectroscopy ("DOSY") is a useful tool for the identification of mixture components. In its basic form it relies on simple differences in hydrodynamic radius to distinguish between different species. This can be very effective where species have significantly different molecular sizes, but generally fails for isomeric species. The use of surfactant co-solutes can allow isomeric species to be distinguished by virtue of their different degrees of interaction with micelles or reversed micelles. The use of micelle-assisted DOSY to resolve the NMR spectra of isomers is illustrated for the case of the three dihydroxybenzenes (catechol, resorcinol, and hydroquinone) in aqueous solution containing sodium dodecyl sulfate micelles, and in chloroform solution containing AOT reversed micelles.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
authors.forename: Robert
authors.initials: R
authors.lastname: Evans
authors.forename: Stephan
authors.initials: S
authors.lastname: Haiber
authors.forename: Mathias
authors.initials: M
authors.lastname: Nilsson
authors.forename: Gareth A
authors.initials: GA
authors.lastname: Morris