Case 41. A misdiagnosis of erythroleukemia.
A 57-year-old woman with splenomegaly, moderate anemia and a paraspinal mass was found to have strikingly increased erythropoiesis, which was left shifted and dysplastic with many multinucleated cells. An increased percentage of CD34-positive and CD117-positive cells suggested a diagnosis of pure erythroleukemia. Further investigations were performed.
Tso
Allison C Y
AC
Department of Haematology, North Middlesex Hospital, London, UK.
Kumaran
Thuraisamy O
TO
Bain
Barbara J
BJ
D001457:Anion Exchange Protein 1, Erythrocyte / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis*; D001797:Blood Protein Electrophoresis; D001856:Bone Marrow Examination; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005434:Flow Cytometry; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D004915:Leukemia, Erythroblastic, Acute / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis*; D013163:Splenomegaly / Q000473:pathology
D001457:Anion Exchange Protein 1, Erythrocyte; D018952:Antigens, CD34; D019009:Proto-Oncogene Proteins c-kit