title: Longitudinal assessment of quality of life in rectal cancer patients with or without stomas following primary resection.
abstract: OBJECTIVE
  The purpose of this study was to assess the longitudinal impact of stoma formation on the health-related quality of life of rectal cancer patients treated with adjuvant chemotherapy.
  
  
  METHODS
  Health-related quality of life data was prospectively collected in a randomized trial designed to compare 24 weeks of bolus 5-fluorouracil/leucovorin with 12 weeks of continuous 5-fluorouracil in patients with resected Dukes B and C colorectal cancer. Health-related quality of life data was collected at baseline, during adjuvant treatment, and at one and three years after completion of chemotherapy.
  
  
  RESULTS
  Between 1993 and 2003, 186 rectal cancer patients were enrolled. One hundred thirty-nine patients had anterior resection, of whom 46 had a temporary defunctioning colostomy. Forty-seven patients had abdominoperineal resection with formation of a permanent colostomy. There was no significant difference in global health-related quality of life between patients with and patients without a stoma at any time point. However, during adjuvant treatment, role (P = 0.04) and social (P = 0.005) functioning were significantly worse in stoma patients than in nonstoma patients. Moreover, the impairment in social functioning persisted at one (P = 0.03) and three years (P = 0.04) after adjuvant chemotherapy.
  
  
  CONCLUSIONS
  Our results demonstrate important adverse effects of either temporary or permanent stoma formation on subsequent health-related quality of life in patients with rectal cancer.
authors.affiliation: Royal Marsden Hospital, London and Surrey, United Kingdom.
authors.forename: Thomas
authors.initials: T
authors.lastname: Yau
authors.forename: David
authors.initials: D
authors.lastname: Watkins
authors.forename: David
authors.initials: D
authors.lastname: Cunningham
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Barbachano
authors.forename: Ian
authors.initials: I
authors.lastname: Chau
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Chong
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000601:surgery*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003125:Colostomy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000601:surgery*
chemical_list: D002955:Leucovorin; D005472:Fluorouracil