title: CTGF and apoptosis in mouse osteocytes induced by tooth movement.
abstract: It is known that experimental tooth movement stimulates the gene expression of connective tissue growth factor (CTGF) and induces apoptosis in osteocytes in rats. We hypothesized that there is a relationship between CTGF expression and the induction of apoptosis in osteocytes, to play a significant role in triggering bone remodeling during experimental tooth movement. In this study, CTGF mRNA expression was detected at 2 hours in osteocytes on the pressure side, followed by apoptosis at 6 hours after tooth movement in mice. The number of empty lacunae significantly increased on day 1 after mechanical stimulation. Thereafter, the number of osteoclasts significantly increased on the pressure side of the alveolar bone on day 3. Tooth movement increased rapidly on day 10. These findings suggest that CTGF expression, followed by apoptosis in osteocytes in response to mechanical stimulation, might play a significant role in triggering bone remodeling during tooth movement.
authors.affiliation: Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai-city 980-8575, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sakai
authors.forename: T A
authors.initials: TA
authors.lastname: Balam
authors.forename: S
authors.initials: S
authors.lastname: Kuroda
authors.forename: N
authors.initials: N
authors.lastname: Tamamura
authors.forename: T
authors.initials: T
authors.lastname: Fukunaga
authors.forename: M
authors.initials: M
authors.lastname: Takigawa
authors.forename: T
authors.initials: T
authors.lastname: Takano-Yamamoto
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000539:Alveolar Process / Q000166:cytology / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology*; D055513:Connective Tissue Growth Factor / Q000235:genetics / Q000378:metabolism*; D020287:In Situ Nick-End Labeling; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010011:Osteocytes / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D018709:Statistics, Nonparametric; D000071681:Tartrate-Resistant Acid Phosphatase; D014087:Tooth Movement Techniques
chemical_list: D007527:Isoenzymes; D012333:RNA, Messenger; D055513:Connective Tissue Growth Factor; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase