title: Changes in hepatic venous morphology with cirrhosis on MRI.
abstract: OBJECTIVE
  To identify changes in vascular morphology on magnetic resonance imaging (MRI) in patients with cirrhosis and to compare these findings to liver donors.
  
  
  METHODS
  Patients undergoing liver transplantation with biopsy-proven cirrhosis (n = 74) and liver donor candidates (n = 85) underwent dynamic gadolinium-enhanced 3D MR at 1.5T. Vessel diameters were measured independently by three radiologists and features of cirrhosis were identified and correlated with cirrhosis.
  
  
  RESULTS
  Hepatic veins were smaller in patients with cirrhosis (4.9, 4.5, and 5.0 mm for right, middle, and left vs. 9.9, 7.6, and 8.9 mm in donors, P << 0.001) and were negatively correlated with cirrhosis (P < 0.001). Right hepatic vein (RHV) <5 mm diagnosed cirrhosis with 59% sensitivity and 99% specificity; the sensitivity and specificity were 88% and 85% for RHV <7 mm. Main portal vein was minimally larger in cirrhosis, 14 versus 12 mm (P < 0.001) in donors. Right portal veins were smaller in cirrhotic patients, 6.5 and 6.2 mm compared to 8.4 and 7.6 mm (P << 0.001), respectively, in donors.
  
  
  CONCLUSIONS
  Vascular features of cirrhosis include small hepatic veins, minimally enlarged main portal vein, and small intrahepatic portal veins; these features may facilitate identification of cirrhosis.
authors.affiliation: Department of Radiology, Qilu Hospital, Shandong University, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiao Ming
authors.initials: XM
authors.lastname: Zhang
authors.forename: Joan C
authors.initials: JC
authors.lastname: Prowda
authors.forename: Hong Lei
authors.initials: HL
authors.lastname: Zhang
authors.forename: Carolina
authors.initials: C
authors.lastname: Sant'anna Henry
authors.forename: George
authors.initials: G
authors.lastname: Shih
authors.forename: Jean C
authors.initials: JC
authors.lastname: Emond
authors.forename: Martin R
authors.initials: MR
authors.lastname: Prince
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006503:Hepatic Veins / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology*; D016031:Liver Transplantation / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014019:Tissue Donors