[Bone fracture and the healing mechanisms. The role of BMP signaling in fracture healing].
When bone tissue, which plays a central role in locomotive organs, is broken by trauma and decreased in its own function of support, it is lead to be remarkable decline in the activity of daily life (ADL). Recently, in a clinical situation, various treatments have been tried for prophylaxis of fractures, and these treatments have been rewarded with good results. However, fractures would be occurred in a certain amount and there would be serious problems in ADL if the treatment fails to repair fractures. Furthermore, fractures could spontaneously heal in several weeks, it can be achieved in early rehabilitation and improvement of ADL, if we can accelerate fracture healing. Bone morphogenetic proteins, which were advocated by Dr. Urist, would be expected to be a key to establish much better society especially for the old.
Imai
Yuuki
Y
Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine.
Takaoka
Kunio
K
D019485:Bone Morphogenetic Proteins / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D017102:Fracture Healing / Q000187:drug effects / Q000235:genetics*; D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology*; D013268:Stimulation, Chemical
D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins