title: Double-outlet right ventricle in a 10-month-old Friesian filly.
abstract: A 10-month-old Friesian filly had a presentation that was consistent with chronic left- and right-sided congestive heart failure. Clinical pathology findings included abnormal haematological and biochemical variables, abnormal blood gas values and increased serum concentration of cardiac troponin I. Echocardiography revealed cardiac chamber dilation and dextropositioning of the aorta. Radiography revealed a generally enlarged heart and pulmonary interstitial infiltration. These findings were supported at necropsy and the diagnosis of double-outlet right ventricle was confirmed. The pathological changes and physiological responses subsequent to double-outlet right ventricle have not previously been described in detail in horses. Clinical progression closely resembles that seen in humans, in whom antemortem diagnosis relies on echocardiography. In horses, complex cardiac disease presents a diagnostic challenge to the clinician. Appropriate therapy must be based on an accurate diagnosis.
authors.affiliation: Department of Veterinary Clinic and Hospital, University of Melbourne, Werribee, Victoria 3030, Australia. lfennell@unimelb.edu.au
authors.forename: Lc
authors.initials: L
authors.lastname: Fennell
authors.forename: S
authors.initials: S
authors.lastname: Church
authors.forename: D
authors.initials: D
authors.lastname: Tyrell
authors.forename: G
authors.initials: G
authors.lastname: Forbes
authors.forename: Ja
authors.initials: J
authors.lastname: Charles
authors.forename: C
authors.initials: C
authors.lastname: McCowan
authors.forename: Cj
authors.initials: C
authors.lastname: Savage
mesh_terms: D000818:Animals; D001344:Autopsy / Q000662:veterinary; D001772:Blood Cell Count / Q000662:veterinary; D001784:Blood Gas Analysis / Q000662:veterinary; D004310:Double Outlet Right Ventricle / Q000097:blood / Q000000981:diagnostic imaging / Q000662:veterinary*; D004562:Electrocardiography / Q000662:veterinary; D017809:Fatal Outcome; D005260:Female; D006734:Horse Diseases / Q000097:blood / Q000151:congenital* / Q000000981:diagnostic imaging; D006736:Horses; D008168:Lung / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D014463:Ultrasonography