title: Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle.
abstract: The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia.
authors.affiliation: School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Murata
authors.forename: Kikuyo
authors.initials: K
authors.lastname: Nakao
authors.forename: Noriko
authors.initials: N
authors.lastname: Hirata
authors.forename: Kensuke
authors.initials: K
authors.lastname: Namba
authors.forename: Takao
authors.initials: T
authors.lastname: Nomi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Kenzo
authors.initials: K
authors.lastname: Moriyama
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shintani
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
authors.forename: Hideaki
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005054:Eugenol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D031721:Piper betle / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; C051268:2-hydroxychavicol; D005054:Eugenol; D014969:Xanthine Oxidase