Nanomolar Hg(II) detection using Nile blue chemodosimeter in biological media.
A Nile blue-based chemodosimeter (1) was newly synthesized, and its application for detection of the Hg(2+) ion in 100% aqueous solution was demonstrated. Upon its addition into aqueous Hg(2+) ion solution, it exhibited a considerable blue-shift in its absorption and emission spectra, driven by a desulfurization reaction. Detection at an emission of 652 nm was extremely sensitive (less than 1.0 ppb), even in biological media such as blood plasma and albumin.
Lee
Min Hee
MH
Department of Chemistry, Korea University, Seoul 136-701, Korea.
Lee
Soon W
SW
Kim
Sang Hoon
SH
Kang
Chulhun
C
Kim
Jong Seung
JS
D000418:Albumins / Q000737:chemistry; D003124:Colorimetry; D005456:Fluorescent Dyes / Q000737:chemistry*; D005470:Fluorometry; D008628:Mercury / Q000032:analysis* / Q000097:blood; D015394:Molecular Structure; D036103:Nanotechnology; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry*; D010670:Phenylthiourea / Q000138:chemical synthesis* / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry
D000418:Albumins; D005456:Fluorescent Dyes; C541186:Nile blue-based chemodosimeter; D010078:Oxazines; D014867:Water; C008619:Nile Blue; D010670:Phenylthiourea; D008628:Mercury