title: Augmentation index is elevated in aortic aneurysm and dissection.
abstract: BACKGROUND
  The augmentation index, the ratio of the ejection pressure from the heart to the reflection pressure from the arterial system, has recently been recognized as one of the indexes of left ventricular afterload. We studied it in patients with aortic aneurysm and dissection, using carotid artery diameter waveform obtained from an echo-tracking system.
  
  
  METHODS
  Forty-six patients were divided into the following three groups based on pathology: group A, 21 patients with thoracic aortic aneurysm; group B, 15 patients with chronic aortic dissection; and group C, 10 patients without any aortic diseases. Using an echo-tracking system on the carotid artery, we measured stiffness parameter beta, arterial compliance, and the augmentation index.
  
  
  RESULTS
  There was no significant difference in stiffness parameter beta and arterial compliance among the three groups. The augmentation index was significantly higher in groups A and B than group C (22 +/- 10%, 22 +/- 13% vs 8 +/- 17%; p = 0.012). Female (p = 0.028) and heart rate (p = 0.005) were significantly associated with the augmentation index and the significance of aortic diseases was marginal (p = 0.056).
  
  
  CONCLUSIONS
  The carotid augmentation index is elevated in patients with aortic aneurysm and dissection.
authors.affiliation: Department of Cardiovascular Surgery, Hokkaido University Hospital, Sapporo, Hokkaido, Japan. y-shingu@mopera.net
authors.forename: Yasushige
authors.initials: Y
authors.lastname: Shingu
authors.forename: Norihiko
authors.initials: N
authors.lastname: Shiiya
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ooka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tachibana
authors.forename: Suguru
authors.initials: S
authors.lastname: Kubota
authors.forename: Satoshi
authors.initials: S
authors.lastname: Morita
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Matsui
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000503:physiopathology / Q000601:surgery*; D001014:Aortic Aneurysm / Q000503:physiopathology* / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000503:physiopathology / Q000601:surgery; D001018:Aortic Diseases / Q000473:pathology / Q000503:physiopathology; D001794:Blood Pressure; D002339:Carotid Arteries / Q000033:anatomy & histology / Q000502:physiology / Q000503:physiopathology; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012044:Regression Analysis; D015203:Reproducibility of Results; D014655:Vascular Resistance