title: Effect of a 2-month treatment with Klamin, a Klamath algae extract, on the general well-being, antioxidant profile and oxidative status of postmenopausal women.
abstract: OBJECTIVE
  Because of a growing demand for alternative treatments of the psychological and somatic/vasomotor symptoms related to menopausal transition, in this study we aimed to investigate the effect of a 2-month supplementation period with the Klamath algae extract (Klamin, Nutratec Srl, Urbino, Italy) on the general and psychological well-being of a group of 21 menopausal women not treated with hormonal therapy, as well as on their oxidative stress status and level of antioxidants. Klamin is an extract naturally rich in powerful algal antioxidant molecules (AFA-phycocyanins) and concentrated with Klamath algae's natural neuromodulators (phenylethylamine as well as natural selective MAO-B inhibitors).
  
  
  CONCLUSIONS
  At the end of the Klamin supplementation period, plasma lipid peroxidation significantly decreased (as proven by a significant lowering of plasma MDA levels), while the overall antioxidant system improved thanks to the significant increase in the plasma levels of carotenoids, tocopherols and retinol. Furthermore, the average Green Scale score, which evaluates menopausal symptoms and thus by contrast the overall and psychological well-being of menopausal women, was significantly reduced. As it did not show the steroid-like effects on the hormonal parameters, Klamin could be proposed both as a valid natural remedy for women seeking an alternative to hormonal therapy, as well as as a complementary treatment for many climacteric symptoms.
authors.affiliation: Nutritherapic Research Center, Urbino, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Scoglio
authors.forename: Serena
authors.initials: S
authors.lastname: Benedetti
authors.forename: Claudia
authors.initials: C
authors.lastname: Canino
authors.forename: Susanna
authors.initials: S
authors.lastname: Santagni
authors.forename: Erika
authors.initials: E
authors.lastname: Rattighieri
authors.forename: Elisa
authors.initials: E
authors.lastname: Chierchia
authors.forename: Franco
authors.initials: F
authors.lastname: Canestrari
authors.forename: Alessandro D
authors.initials: AD
authors.lastname: Genazzani
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage*; D000529:Complementary Therapies / Q000379:methods*; D056890:Eukaryota; D005260:Female; D006304:Health Status; D006728:Hormones / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood; D008593:Menopause / Q000187:drug effects / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D017698:Postmenopause / Q000187:drug effects* / Q000378:metabolism*; D014815:Vitamins / Q000097:blood
chemical_list: D000975:Antioxidants; D006728:Hormones; D014815:Vitamins; D008315:Malondialdehyde