title: Clinical evaluation of a fully automated model-based algorithm to calculate left ventricular volumes and ejection fraction using multidetector computed tomography.
abstract: OBJECTIVE
  To evaluate feasibility and accuracy of a fully automatic algorithm (FAA) for calculating left ventricular volumes and ejection fraction (LVEF) from multidetector computed tomography (MDCT) studies versus a previously validated method based on Simpson's method serving as our reference standard (RS), and left ventriculography (LVG), in patients with acute chest pain (ACP).
  
  
  METHODS
  23 patients admitted with ACP underwent ECG-gated MDCT, as well as LVG during their hospitalization. MDCT based end-diastolic, end-systolic and stroke volumes (EDV, ESV, SV) and LVEF were calculated using the RS and the FAA.
  
  
  RESULTS
  One patient was excluded after FAA failure to detect contours. In the remaining 22 patients, mean+/-SD LVEF measurements were RS 61+/-11%, FAA 59+/-11% (r = 0.91 versus RS), LVG 57+/-16% (r = 0.6 versus RS). In comparison to RS, FAA overestimated EDV by 10.1+/-8.5 ml, ESV by 7.3+/-6.4 ml and SV by 3.6+/-8.6 ml, and underestimated LVEF measurements by 2.7+/-4.6%, related to contour smoothing. LVEF by FAA was within 8% of RS for all patients except one. In contrast, LVG differed significantly from RS.
  
  
  CONCLUSIONS
  The evaluated FAA obtained accurate, clinically relevant results for left ventricular volumes and LVEF relative to the RS.
authors.affiliation: Department of Diagnostic Imaging, Israel Institute of Technology, Haifa, Israel.
authors.forename: Eduard
authors.initials: E
authors.lastname: Ghersin
authors.forename: Sobhi
authors.initials: S
authors.lastname: Abadi
authors.forename: Sergey
authors.initials: S
authors.lastname: Yalonetsky
authors.forename: Ahuva
authors.initials: A
authors.lastname: Engel
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lessick
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology; D000465:Algorithms; D001331:Automation / Q000379:methods*; D002306:Cardiac Volume / Q000502:physiology*; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008962:Models, Theoretical; D011446:Prospective Studies; D015203:Reproducibility of Results; D013318:Stroke Volume / Q000502:physiology*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016277:Ventricular Function, Left / Q000502:physiology*