[Conditional lethal mutations shift the genome from stability to instability].
The phenomenology of genomic destabilization is described in Drosophila melanogaster mutants containing radiation-induced conditional dominant lethals in the X chromosome and in autosome 2. Destabilization manifests itself as (1) the loss or decrease of lethality of previously lethal mutations; (2) the loss of expression of visible dominant mutations in an opposite homolog; (3) chromosomal instability resulting in the loss of the X chromosome in germline and somatic cells; (4) the occurrence of novel mutations (secondary mutagenesis); (5) the occurrence of single and mass modifications; (6) disturbances in individual development (formation of morphoses). The key event for the shift of the genome from the stable state into the unstable one is the occurrence of a conditional dominant lethal mutation.
Chadov
B F
BF
Chadova
E V
EV
Khotskina
E A
EA
Fedorova
N B
NB
D000818:Animals; D004331:Drosophila melanogaster; D005799:Genes, Dominant / Q000235:genetics*; D049750:Genome, Insect / Q000235:genetics*; D042822:Genomic Instability / Q000235:genetics*; D016296:Mutagenesis; D009154:Mutation; D014960:X Chromosome / Q000235:genetics*