title: Prevalence of the angiotensin I converting enzyme gene insertion/deletion polymorphism in a healthy Turkish population.
abstract: Angiotensin converting enzyme (ACE) plays an essential role in the renin-angiotensin system. It converts angiotensin I to angiotensin II and inactivates bradykinin and tachykinins. Numerous studies have been published investigating associations of the ACE gene I/D polymorphism with various pathophysiological conditions. We examined the prevalence of the ACE I/D polymorphism in a sample of healthy volunteers from western Turkey, including 1063 healthy Turkish controls. Analysis of the ACE I/D gene polymorphisms by polymerase chain reaction found frequencies of 16.1% for the II genotype, 47.7% for the ID genotype, and 36.2% for the DD genotype. The allele frequency was 39.9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations.
authors.affiliation: Molecular Medicine Laboratory, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey.
authors.forename: Afig
authors.initials: A
authors.lastname: Berdeli
authors.forename: F Sirri
authors.initials: FS
authors.lastname: Cam
mesh_terms: D000328:Adult; D000483:Alleles; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D014421:Turkey; D055815:Young Adult
chemical_list: D007703:Peptidyl-Dipeptidase A