Senescence mediated redox imbalance in cardiac tissue: Antioxidant rejuvenating potential of green tea extract.
OBJECTIVE
The activities and capacities of antioxidant systems of tissue cells are declined during aging, leading to the gradual loss of pro-oxidant/antioxidant balance and accumulation of oxidative damage. Hence, the present study evaluated the role of green tea extract (GTE), rich in polyphenols, in combating age-associated macromolecular damage in rat cardiac tissue.


METHODS
The antioxidant defense system, lipid peroxidation, protein oxidation, and redox status in heart tissue were studied using young and aged rats.


RESULTS
Significant increases in lipid peroxidation, protein carbonyls, and marked decreases in glutathione redox status, protein thiols, and activities of enzymatic and non-enzymatic antioxidants were observed in aged rats compared with young rats. Supplementation of GTE (100 mg/kg of body weight per day) orally for 30 days ameliorated these changes significantly.


CONCLUSIONS
This study accredits GTE's antioxidant rejuvenating potency and its role in the amelioration of senescence-mediated redox imbalance in aged rat cardiac tissue.
Kumaran
Vadivel Senthil
VS
Department of Medical Biochemistry, DR.ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
Arulmathi
Karpagavinayagam
K
Kalaiselvi
Periandavan
P
D000367:Age Factors; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D028241:Camellia sinensis; D016922:Cellular Senescence / Q000187:drug effects*; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D050050:Protein Carbonylation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000378:metabolism
D000975:Antioxidants; D010936:Plant Extracts; D013438:Sulfhydryl Compounds; D005978:Glutathione; D019803:Glutathione Disulfide