title: [Mechanism of donor T cell migration and homing in the pathophysiology of acute graft-versus-host disease - review].
abstract: Migration of donor T cells to the host second lymphoid organs and homing of activated donor T cells into the target tissues play crucial role in the pathophysiology of acute graft-versus-host disease (aGVHD). More deep understanding of the mechanisms for donor T cell migration and homing reveals an important significance in preventing the initiation of aGVHD. In this review, the migration of donor T cells to host second lymphoid organs, homing of donor activated T cells into the target organs, homing of regulating T cells into target organs, the mechanisms of T cell migration and homing in process of aGVHD and its study prospects were summarised.
authors.affiliation: Department of Hematology, Beijing University First Hospital, Beijing 100034, China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Sun
authors.forename: Han-Yun
authors.initials: HY
authors.lastname: Ren
mesh_terms: D002465:Cell Movement; D006086:Graft vs Host Disease; D006801:Humans; D016201:Receptors, Lymphocyte Homing; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*
chemical_list: D016201:Receptors, Lymphocyte Homing