title: Gliosarcoma with osteosarcomatous features: a short illustrated review.
abstract: BACKGROUND
  Gliosarcoma is a rare, malignant, biphasic brain tumor formed by both glioblastoma and sarcomatous components. Various lines of differentiation are described in the latter component, but most commonly fibrosarcomatous and pleomorphic sarcoma are present. Osteosarcomatous features are exceedingly rare.
  
  
  OBJECTIVE
  We report a case of gliosarcoma with osteosarcomatous features in a 33-year-old woman.
  
  
  METHODS
  Histologically, the sarcomatous portion displayed a typical pattern of fibrosarcoma associated with areas of osteoid formation.
  
  
  CONCLUSIONS
  Immunohistochemical glial fibrillary acid protein (GFAP) expression was seen only in the glioblastoma portion. Clinicopathological characteristics and radiological data of this rare condition were reviewed. Possible differential diagnoses and potential histogenesis were also discussed.
authors.affiliation: Pathology Department, Habib Bourguiba University Hospital, El Ain Road, 3029 Sfax, Tunisia. charfislim@gmail.com
authors.forename: Slim
authors.initials: S
authors.lastname: Charfi
authors.forename: Lobna
authors.initials: L
authors.lastname: Ayadi
authors.forename: Abdelmajid
authors.initials: A
authors.lastname: Khabir
authors.forename: Emna
authors.initials: E
authors.lastname: Daoud
authors.forename: Rim
authors.initials: R
authors.lastname: Kallel
authors.forename: Oussama
authors.initials: O
authors.lastname: Kharrat
authors.forename: Zeineb
authors.initials: Z
authors.lastname: Mnif
authors.forename: Zaher
authors.initials: Z
authors.lastname: Boudawara
authors.forename: Saloua
authors.initials: S
authors.lastname: Makni
authors.forename: Tahya
authors.initials: T
authors.lastname: Boudawara
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D049109:Cell Proliferation; D004475:Ectoderm / Q000378:metabolism / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000378:metabolism; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D018316:Gliosarcoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D006261:Headache / Q000209:etiology; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D011859:Radiography; D011878:Radiotherapy; D012086:Reoperation; D015996:Survival Rate; D015354:Vision, Low / Q000209:etiology; D014839:Vomiting / Q000209:etiology
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein