title: In vitro elution of daptomycin by a synthetic crystallic semihydrate form of calcium sulfate, stimulan.
abstract: A synthetic crystallic semihydrate form of calcium sulfate, Stimulan, was evaluated as a biodegradable carrier for the daily in vitro elution of daptomycin. Daptomycin and Stimulan were admixed at a ratio of 95:5. Elution lasted for 28 days. Eluted concentrations peaked on days 1 and 11, when the mean values were 1,320.1 and 949.2 microg/ml, respectively. The lowest eluted concentration was detected on day 28. These results support the application of the system described in experimental models of osteomyelitis.
authors.affiliation: 4th Department of Internal Medicine, ATTIKON University Hospital, 1 Rimini Street, Athens, Greece.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Kanellakopoulou
authors.forename: Periklis
authors.initials: P
authors.lastname: Panagopoulos
authors.forename: Efthymia
authors.initials: E
authors.lastname: Giannitsioti
authors.forename: Thomas
authors.initials: T
authors.lastname: Tsaganos
authors.forename: Dionyssia-Pinelopi
authors.initials: DP
authors.lastname: Carrer
authors.forename: Nicolas
authors.initials: N
authors.lastname: Efstathopoulos
authors.forename: Evangelos J
authors.initials: EJ
authors.lastname: Giamarellos-Bourboulis
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D002133:Calcium Sulfate / Q000737:chemistry*; D017576:Daptomycin / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D017576:Daptomycin; D002133:Calcium Sulfate