title: MetaTISA: Metagenomic Translation Initiation Site Annotator for improving gene start prediction.
abstract: CONCLUSIONS
  We proposed a tool named MetaTISA with an aim to improve TIS prediction of current gene-finders for metagenomes. The method employs a two-step strategy to predict translation initiation sites (TISs) by first clustering metagenomic fragments into phylogenetic groups and then predicting TISs independently for each group in an unsupervised manner. As evaluated on experimentally verified TISs, MetaTISA greatly improves the accuracies of TIS prediction of current gene-finders.
  
  
  BACKGROUND
  The C++ source code is freely available under the GNU GPL license via http://mech.ctb.pku.edu.cn/MetaTISA/.
authors.affiliation: State Key Laboratory for Turbulence and Complex Systems, Department of Biomedical Engineering and Center for Theoretical Biology, Peking University, Beijing 100871, China.
authors.forename: Gang-Qing
authors.initials: GQ
authors.lastname: Hu
authors.forename: Jiang-Tao
authors.initials: JT
authors.lastname: Guo
authors.forename: Yong-Chu
authors.initials: YC
authors.lastname: Liu
authors.forename: Huaiqiu
authors.initials: H
authors.lastname: Zhu
mesh_terms: D005796:Genes; D023281:Genomics / Q000379:methods*; D010442:Peptide Chain Initiation, Translational; D010802:Phylogeny; D017422:Sequence Analysis, DNA / Q000379:methods; D012984:Software