Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
OBJECTIVE
Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, some studies have suggested that SIRT1 could be over-expressed in breast, prostate and colon cancers and up-regulated SIRT1 inactivates p53 by deacetylation. Therefore, we investigated the prevalence and the prognostic impact of SIRT1 and p53 expression in ovarian epithelial tumours.


METHODS
Immunohistochemical expression of SIRT1 and p53 were evaluated using tissue microarray in 40 cases of benign epithelial tumours, 36 cases of borderline tumours, and 90 cases of malignant tumours.


RESULTS
Expression of SIRT1 was significantly increased in malignant epithelial tumours compared to benign and borderline epithelial tumours (p < 0.001). In particular, a high proportion of serous carcinoma expressed SIRT1 (86%, 55/64 cases). Despite the frequent expression of SIRT1 in malignant ovarian epithelial tumours, serous carcinomas of high FIGO stage showed less frequent SIRT1 expression compared to that of low stage serous carcinomas (p = 0.029). Moreover, increased expression of SIRT1 in serous carcinoma correlated with increased overall survival by univariate (p = 0.014) and multivariate analyses.


CONCLUSIONS
Over-expression of SIRT1 may play an important role in the early stage of ovarian carcinogenesis.
Jang
Kyu Yun
KY
Department of Pathology, Medical School and Institute for Medical Sciences, Chonbuk National University, Dukjin-Gu, Jeonju, Jeonbuk, Republic of Korea.
Kim
Kwan Sik
KS
Hwang
Sung Ho
SH
Kwon
Keun Sang
KS
Kim
Kyung Ryoul
KR
Park
Ho Sung
HS
Park
Byung-Hyun
BH
Chung
Myoung Ja
MJ
Kang
Myoung Jae
MJ
Lee
Dong Geun
DG
Moon
Woo Sung
WS
D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D056564:Sirtuin 1; D037761:Sirtuins / Q000096:biosynthesis*; D046888:Tissue Array Analysis
D014408:Biomarkers, Tumor; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins