New insights into mTOR signaling: mTORC2 and beyond.
The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid-induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.
Alessi
Dario R
DR
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15EH, Scotland, UK. d.r.alessi@dundee.ac.uk
Pearce
Laura R
LR
García-Martínez
Juan M
JM
D000595:Amino Acid Sequence; D000818:Animals; D049109:Cell Proliferation; D006801:Humans; D017874:Immediate-Early Proteins / Q000378:metabolism; D008954:Models, Biological; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D012694:Serine / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases; D013912:Threonine / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D000099184:Serum-Glucocorticoid Regulated Kinases
D017874:Immediate-Early Proteins; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D012694:Serine; D058570:TOR Serine-Threonine Kinases; D013912:Threonine; D014157:Transcription Factors; D000099184:Serum-Glucocorticoid Regulated Kinases; C493245:CRTC2 protein, human; C546842:MTOR protein, human