More pieces in the promoter jigsaw: recognition of -10 regions by alternative sigma factors.
Two papers in this issue of Molecular Microbiology from Carol Gross and colleagues describe experiments that investigate how two alternative Escherichia coli sigma proteins recognize target promoter -10 regions. A combination of genetics, biochemistry and bioinformatics is used to show that determinants in two adjacent domains of the sigma proteins contact discrete sequence elements in the -10 regions.
Busby
Stephen J W
SJ
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. s.j.w.busby@bham.ac.uk
D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D008958:Models, Molecular; D011401:Promoter Regions, Genetic; D017434:Protein Structure, Tertiary; D012808:Sigma Factor / Q000235:genetics / Q000378:metabolism*
D029968:Escherichia coli Proteins; D012808:Sigma Factor