title: Recent developments in the treatment of uveitis: an update.
abstract: The management of complex uveitis is often based around the use of oral corticosteroids. To spare the side effects of corticosteroids, second-line oral immunosuppressant drugs are used. Newer systemic immunosuppressive drugs, including biologics, and locally delivered treatments are being evaluated. This article reviews current conventional treatments, discusses their limitations and evaluates newer treatment strategies. Current theories about the pathogenesis of uveitis and potential targets for treatment are discussed in this context. We are still in search of a low-risk, where possible, locally delivered and targeted treatment for uveitis.
authors.affiliation: Academic Unit of Ophthalmology, York Hospital, Wigginton Road, York YO318HE, UK.
authors.forename: Fiona
authors.initials: F
authors.lastname: Lyon
authors.forename: Richard P
authors.initials: RP
authors.lastname: Gale
authors.forename: Susan
authors.initials: S
authors.lastname: Lightman
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D055808:Drug Discovery / Q000379:methods / Q000639:trends*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents