title: Brain-derived neurotrophic factor serum levels before and after treatment for acute mania.
abstract: Accumulating evidence suggests that reduced levels of brain-derived neurotrophic factor (BDNF) in acute mood episodes may play an important role in the pathophysiology of bipolar disorder (BD). In order to assess changes in BDNF serum levels in BD patients before and after treatment for acute mania, ten bipolar patients were prospectively examined at inpatient unit admission and discharge. Diagnoses were made using the Structured Clinical Interview for DSM-IV, SCID-I. Serum BDNF levels were measured by sandwich ELISA. The results showed that BDNF levels were decreased in BD patients during mania when compared to controls (p=0.013) but this difference was no longer significant after treatment (p=0.126). A sharp increase in BDNF levels was found after treatment of the episode of acute mania (p=0.010). These findings suggest that the changes in BDNF serum levels may be associated with treatment response in acute mania. Further studies designed to validate the use of BDNF as a marker of treatment response in bipolar disorder are warranted.
authors.affiliation: Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Brazil.
authors.forename: Juliana Fernandes
authors.initials: JF
authors.lastname: Tramontina
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Andreazza
authors.forename: Marcia
authors.initials: M
authors.lastname: Kauer-Sant'anna
authors.forename: Laura
authors.initials: L
authors.lastname: Stertz
authors.forename: Julia
authors.initials: J
authors.lastname: Goi
authors.forename: Fabria
authors.initials: F
authors.lastname: Chiarani
authors.forename: Flávio
authors.initials: F
authors.lastname: Kapczinski
mesh_terms: D000293:Adolescent; D000328:Adult; D018692:Antimanic Agents / Q000494:pharmacology*; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018692:Antimanic Agents; D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor