[Evaluation on in vitro release of Chinese medicinal compound sustained release preparations using multi-index chromatographic fingerprint].
OBJECTIVE
To establish a method to evaluate the in vitro release of Chinese medicinal compound sustained release preparations using multi-index chromatographic fingerprint.


METHODS
With the Chinese medicinal compound Jiangya sustained tablets as model preparation, the in vitro cumulative release of the main component flavones and fingerprint were determined by HPLC fingerprint. Aacacetin, rutin, luteolin, fingerprint were determined simultaneously and used to calculate the in vitro cumulative release of the tablets.


RESULTS
Aacacetin, rutin, luteolin, and the fingerprint had different cumulative release.


CONCLUSIONS
Multi-index chromatographic fingerprint can reflect different content of multi components of preparations and can be used in the evaluation on in vitro release of the sustained release preparations of Chinese medicinal compound. The method is simple, rapid, and of multi information.
Liu
Qingfei
Q
Institute of Biomedicine, Tsinghua University, Beijing 100084, China. liuqf@mail.tsinghua.edu.cn
Wang
Yiming
Y
Luo
Guoan
G
D002845:Chromatography; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism*; D013997:Time Factors
D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal