title: Anterior cerebrospinal fluid leaks in children and adults: five years experience.
abstract: OBJECTIVE
  To describe surgical experience in the repair of anterior skull base defects, we studied patients with congenital or acquired defects. According to a multidisciplinary evaluation, all subjects underwent surgery performed by an ENT surgeon in order to avoid craniotomy.
  
  
  METHODS
  Retrospective study of patients who were treated for an anterior skull base defect between 2000 and 2005 at a tertiary referral centre.
  
  
  METHODS
  Twelve patients had surgery to correct anterior skull base defects. Four patients had spontaneous anterior basal defect and eight had a post-traumatic cerebrospinal fluid (CSF) leakage. The diagnosis was made with imaging studies: Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) scans, possibly supplemented by a cisternography. The defects were repaired using the endoscopic endonasal approach excepted in frontal sinus location.
  
  
  RESULTS
  CT and MRI scans demonstrated the defect in all but two cases. In one of them, MR cisternography showed the intranasal sac and in the other CT cisternography demonstrated a CSF fistula without any bone defect at the ethmoid roof. After surgery, the follow-up period was at least 16 months (mean 26 months). Success rate at first attempt was 83%. Two adults needed a second surgical repair with successful outcome in one, increasing the success rate to 92% after the second attempt. One female patient, obese with a body mass index > 30 and hydrocephaly, had a recurrence of CSF leakage despite surgical revision. Postoperative imaging studies, CT scan or MRI, showed that the defect had successfully been repaired in 11 patients.
  
  
  CONCLUSIONS
  High-resolution CT scan, MRI with or without cisternography, should investigate osteo-meningeal defect. Our report confirms that endonasal surgical techniques are useful for treating meningoceles and meningo-encephaloceles. The external route is to be preferred when the lesion is located in the apex of the frontal sinus.
authors.affiliation: Université François-Rabelais, Tours, France. lescanne@med.univ-tours.fr
authors.forename: E
authors.initials: E
authors.lastname: Lescanne
authors.forename: D
authors.initials: D
authors.lastname: Bakhos
authors.forename: B
authors.initials: B
authors.lastname: Aesch
authors.forename: Z
authors.initials: Z
authors.lastname: Celebi
authors.forename: J
authors.initials: J
authors.lastname: Maheut-Lourmiere
authors.forename: J P
authors.initials: JP
authors.lastname: Cottier
authors.forename: S
authors.initials: S
authors.lastname: Morinière
mesh_terms: D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D002555:Cerebrospinal Fluid; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019291:Skull Base / Q000002:abnormalities* / Q000293:injuries* / Q000601:surgery; D055815:Young Adult