Myelin peptides in multiple sclerosis.
The development of specific therapies for organ-specific autoimmune diseases requires the identification of relevant immunogenic epitopes, recognized by both pathogenic T cells and autoantibodies. Here, we review the most relevant studies focused in the identification of peptides in multiple sclerosis (MS) and the distinct T cell reactivity induced in patients compared to controls. Only a few studies reported significant differences in terms of T cell reactivity to them. The current knowledge on this issue, and the diagnostic and therapeutic possibilities opened by the identification of pathogenic MS epitopes are discussed in this paper.
Grau-López
L
L
Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Raïch
D
D
Ramo-Tello
C
C
Naranjo-Gómez
M
M
Dàvalos
A
A
Pujol-Borrell
R
R
Borràs
F E
FE
Martínez-Cáceres
E
E
D000818:Animals; D000941:Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy*; D009186:Myelin Sheath / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D009418:S100 Proteins / Q000276:immunology; D014153:Transaldolase / Q000276:immunology; D038203:alpha-Crystallin B Chain / Q000276:immunology
D000941:Antigens; D018992:Myelin-Associated Glycoprotein; D010455:Peptides; D009418:S100 Proteins; D038203:alpha-Crystallin B Chain; D014153:Transaldolase