title: Theta Burst Stimulation over the human primary motor cortex modulates neural processes involved in movement preparation.
abstract: OBJECTIVE
  To test whether inhibitory continuous Theta Burst (cTBS) transcranial magnetic stimulation (TMS) can alter neural activity involved in planning and execution of a self-paced movement.
  
  
  METHODS
  In seven subjects, cTBS was applied over either the left or right primary motor cortex (left M1 and right M1) and the left dorsal premotor cortex (left PMd) in different experimental sessions. Motor evoked potentials (MEP) at rest were measured as well as the two main components of the movement related cortical potential (MRCP), the Bereitschaftspotential (BP) and the negative slope (NS'), prior to self-paced right thumb opposition.
  
  
  RESULTS
  cTBS suppressed contralateral MEPs when it was applied over left M1, right M1 and left PMd. In addition, cTBS over left M1, but not at any other location, reduced the amplitude of the NS' and tended to shorten the BP onset without changing EMG activity associated with voluntary muscular output. There was a significant correlation between the percent suppression of the MEP and the reduction in amplitude of the total MRCP (BP+NS').
  
  
  CONCLUSIONS
  cTBS can produce long-lasting effects on brain activity involved in the preparation and execution of a volitional movement.
  
  
  CONCLUSIONS
  The fact that movement was not compromised while brain activity changed suggests that the motor system of healthy subjects operates with a safety factor that can adjust patterns of activation to compensate for the partial disruption caused by cTBS.
authors.affiliation: Institute of Neurology, Sobell Department of Motor Neuroscience and Movement Disorders, University College London, Queen Square, London WC1N 3BG, UK.
authors.forename: Enzo
authors.initials: E
authors.lastname: Ortu
authors.forename: Diane
authors.initials: D
authors.lastname: Ruge
authors.forename: Franca
authors.initials: F
authors.lastname: Deriu
authors.forename: John C
authors.initials: JC
authors.lastname: Rothwell
mesh_terms: D000328:Adult; D004569:Electroencephalography; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005385:Fingers / Q000294:innervation / Q000502:physiology; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D013569:Synapses / Q000502:physiology; D013826:Theta Rhythm; D050781:Transcranial Magnetic Stimulation / Q000379:methods*