Development of boron nanocapsules for neutron capture therapy.
High accumulation and selective delivery of boron into tumor tissues are the most important requirements to achieve efficient neutron capture therapy of cancers. We focused on liposomal boron delivery system in order to achieve a large amount of boron delivery to tumor. We synthesized the double-tailed boron cluster lipid 4c according to our reported procedure with modification. Size distribution of liposomes prepared from the boron cluster lipid 4c, DMPC, PEG-DSPE, and cholesterol was determined as 100 nm in diameter by an electrophoretic light scattering spectrophotometer. A high level of (10)B concentration (22 ppm) was observed in tumor tissue at 24 h after the administration of boron liposomes.
Nakamura
H
H
Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171-8588, Japan. hiroyuki.nakamura@gakushuin.ac.jp
Ueno
M
M
Ban
H S
HS
Nakai
K
K
Tsuruta
K
K
Kaneda
Y
Y
Matsumura
A
A
D000818:Animals; D001896:Boron Compounds / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D007554:Isotopes / Q000008:administration & dosage / Q000627:therapeutic use; D008081:Liposomes / Q000737:chemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000532:radiotherapy; D010316:Particle Size; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D014018:Tissue Distribution
D001896:Boron Compounds; D007554:Isotopes; D008081:Liposomes; D053769:Nanocapsules; D011838:Radiation-Sensitizing Agents