title: Contact allergy in chronic leg ulcers: results of a multicentre study carried out in 423 patients and proposal for an updated series of patch tests.
abstract: BACKGROUND
  There is a lack of prospective studies investigating contact sensitization in patients with chronic leg ulcers.
  
  
  OBJECTIVE
  To determine the frequency of contact sensitization in patients with chronic leg ulcers using a special series of patch tests and to determine whether the number of sensitizations was correlated with the duration of the chronic leg ulcers.
  
  
  METHODS
  Multicentre study carried out in patients with chronic leg ulcers; patch tests with the European baseline series and with an additional 34 individual allergens or mixes and 3 commercial products.
  
  
  RESULTS
  Of the 423 patients (301 women, 122 men, mean age 68.5 years) with chronic leg ulcers, 308 (73%) had at least one positive patch test with 3.65 positive patch tests per patient. The main allergens were Myroxylon pereirae (41%), fragrance mix I (26.5%), antiseptics (20%), and corticosteroids (8%). The number of positive tests per patient was not correlated with the cause of ulcer but was increased with the duration of the ulcer with a statistical difference between the group of the <1 year compared with the group >10 years duration.
  
  
  CONCLUSIONS
  From this large prospective multicentre study, polysensitization is frequent in patients with chronic leg ulcers, increasing with the duration of the ulcer. We propose avoidance of topical antiseptics and ointments containing perfumes in patients with chronic leg ulcers and an updated patch test series for investigating these patients.
authors.affiliation: Dermatology Department, Fournier Hospital, University Hospital of Nancy, Nancy, France. a.barbaud@chu-nancy.fr
authors.forename: Annick
authors.initials: A
authors.lastname: Barbaud
authors.forename: Evelyne
authors.initials: E
authors.lastname: Collet
authors.forename: Christophe J
authors.initials: CJ
authors.lastname: Le Coz
authors.forename: Sylvie
authors.initials: S
authors.lastname: Meaume
authors.forename: Pierre
authors.initials: P
authors.lastname: Gillois
mesh_terms: D000305:Adrenal Cortex Hormones / Q000633:toxicity; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000633:toxicity; D000893:Anti-Inflammatory Agents / Q000633:toxicity; D001458:Bandages / Q000009:adverse effects; D002908:Chronic Disease; D015897:Comorbidity; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D029904:Myroxylon / Q000633:toxicity; D010328:Patch Tests; D010476:Perfume / Q000633:toxicity; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D000891:Anti-Infective Agents, Local; D000893:Anti-Inflammatory Agents; D010476:Perfume