title: Robust filtering for stochastic genetic regulatory networks with time-varying delay.
abstract: This paper addresses the robust filtering problem for a class of linear genetic regulatory networks (GRNs) with stochastic disturbances, parameter uncertainties and time delays. The parameter uncertainties are assumed to reside in a polytopic region, the stochastic disturbance is state-dependent described by a scalar Brownian motion, and the time-varying delays enter into both the translation process and the feedback regulation process. We aim to estimate the true concentrations of mRNA and protein by designing a linear filter such that, for all admissible time delays, stochastic disturbances as well as polytopic uncertainties, the augmented state estimation dynamics is exponentially mean square stable with an expected decay rate. A delay-dependent linear matrix inequality (LMI) approach is first developed to derive sufficient conditions that guarantee the exponential stability of the augmented dynamics, and then the filter gains are parameterized in terms of the solution to a set of LMIs. Note that LMIs can be easily solved by using standard software packages. A simulation example is exploited in order to illustrate the effectiveness of the proposed design procedures.
authors.affiliation: School of Information Sciences and Technology, Donghua University, Shanghai 200051, China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Wei
authors.forename: Zidong
authors.initials: Z
authors.lastname: Wang
authors.forename: James
authors.initials: J
authors.lastname: Lam
authors.forename: Karl
authors.initials: K
authors.lastname: Fraser
authors.forename: Ganti Prasada
authors.initials: GP
authors.lastname: Rao
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D025461:Feedback, Physiological / Q000235:genetics; D053263:Gene Regulatory Networks / Q000502:physiology*; D007700:Kinetics; D016014:Linear Models; D008957:Models, Genetic; D011506:Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D013269:Stochastic Processes; D013997:Time Factors
chemical_list: D011506:Proteins; D012333:RNA, Messenger