title: The detection of Bovine Papillomavirus type 1 DNA in flies.
abstract: BPVs are double stranded DNA viruses that can infect several species other than the natural host, cattle, including equids. In equids, BPV-1, and, less commonly BPV-2, infection gives rise to fibroblastic tumours of the skin. Whilst a causal relationship between BPV-1/2 and equine sarcoids is now well established, how the disease is transmitted is not known. In this study we show BPV-1 DNA can be detected in flies trapped in the proximity of sarcoid-affected animals. Sequence analysis of the BPV-1 LCR from flies indicates that flies harbour BPV-1 LCR sequence variants II and IV which are commonly detected in equine sarcoids. These data suggest that flies may be able to transmit BPV-1 between equids.
authors.affiliation: Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK.
authors.forename: Margaret
authors.initials: M
authors.lastname: Finlay
authors.forename: ZhengQiang
authors.initials: Z
authors.lastname: Yuan
authors.forename: Faith
authors.initials: F
authors.lastname: Burden
authors.forename: Andrew
authors.initials: A
authors.lastname: Trawford
authors.forename: Iain M
authors.initials: IM
authors.lastname: Morgan
authors.forename: M Saveria
authors.initials: MS
authors.lastname: Campo
authors.forename: Lubna
authors.initials: L
authors.lastname: Nasir
mesh_terms: D000818:Animals; D052688:Bovine papillomavirus 1 / Q000302:isolation & purification*; D004279:DNA, Viral / Q000235:genetics; D004175:Diptera / Q000821:virology*; D004199:Disease Vectors; D006734:Horse Diseases / Q000635:transmission / Q000821:virology*; D006736:Horses; D006799:Housing, Animal; D017422:Sequence Analysis, DNA; D017193:Skin Diseases, Viral / Q000635:transmission / Q000662:veterinary*
chemical_list: D004279:DNA, Viral