title: CLC-7: a potential therapeutic target for the treatment of osteoporosis and neurodegeneration.
abstract: CLC-7 is a member of the voltage-gated chloride channels family. It resides mainly in the late endosomes, lysosomes and the ruffled membrane of osteoclasts. Mice deficient in the ubiquitously expressed ClC-7 Cl(-) channel show severe osteopetrosis and retinal degeneration. In the present review, some of the known features of CLC-7 such as structure, function and its roles in physiological or pathophysiological processes are highlighted.
authors.affiliation: College of Chemical Engineering, Northeast Dianli University, Jilin, PR China. Xiaozhaoqingxiao@163.com
authors.forename: Qingxiao
authors.initials: Q
authors.lastname: Zhao
authors.forename: Qun
authors.initials: Q
authors.lastname: Wei
authors.forename: Aimin
authors.initials: A
authors.lastname: He
authors.forename: Ruokun
authors.initials: R
authors.lastname: Jia
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000818:Animals; D018118:Chloride Channels / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D010022:Osteopetrosis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D012162:Retinal Degeneration / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism
chemical_list: C097540:CLCN7 protein, human; D018118:Chloride Channels