Zn/InCl(3)-mediated pinacol cross-coupling reactions of aldehydes with alpha,beta-unsaturated ketones in aqueous media.
A zinc/indium chloride-mediated pinacol cross-coupling reaction between aldehyde and alpha,beta-unsaturated ketone in aqueous media was developed. The 1,2-diols were obtained in moderate to good yields with up to 93:7 diastereoselectivity.
Yang
Yong-Sheng
YS
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
Shen
Zhi-Liang
ZL
Loh
Teck-Peng
TP