Epileptic spasms after stem cell transplantation for chronic Epstein-Barr virus infection.
Stem cell transplantation has been performed for various diseases, contributing to a markedly improved prognosis in some cases. However, several complications, including posterior reversible encephalopathy syndrome, have been evident. Although posterior reversible encephalopathy syndrome was originally defined as a reversible disease, it has become clear that it is not reversible in all patients. Epstein-Barr virus causes a wide spectrum of neurologic disorders, including epilepsy. To our knowledge, Epstein-Barr virus was not previously reported to cause epileptic spasms. We describe a girl with epileptic spasms after posterior reversible encephalopathy syndrome associated with stem cell transplantation for chronic Epstein-Barr virus infection. Although direct correlation was not clarified, this is a rare case that may contribute to our understanding of the neurologic complications of stem cell transplantation for chronic Epstein-Barr virus infection.
Ishikawa
Nobutsune
N
Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Minami-ku, Hiroshima, Japan. ishikan@hiroshima-u.ac.jp
Tajima
Go
G
Kobayashi
Masao
M
D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D002675:Child, Preschool; D000075202:Contraindications; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D033581:Stem Cell Transplantation; D013577:Syndrome