title: Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep.
abstract: Long-term changes in dopaminergic signaling are thought to underlie the pathophysiology of a number of psychiatric disorders. Several conditions are associated with cognitive deficits such as disturbances in attention processes and learning and memory, suggesting that persistent changes in dopaminergic signaling may alter neural mechanisms underlying these processes. Dopamine transporter knockout (DAT-KO) mice exhibit a persistent five-fold increase in extracellular dopamine levels. Here, we demonstrate that DAT-KO mice display lower hippocampal theta oscillation frequencies during baseline periods of waking and rapid-eye movement sleep. These altered theta oscillations are not reversed via treatment with the antidopaminergic agent haloperidol. Thus, we propose that persistent hyperdopaminergia, together with secondary alterations in other neuromodulatory systems, results in lower frequency activity in neural systems responsible for various cognitive processes.
authors.affiliation: Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Kafui
authors.initials: K
authors.lastname: Dzirasa
authors.forename: Lucas M
authors.initials: LM
authors.lastname: Santos
authors.forename: Sidarta
authors.initials: S
authors.lastname: Ribeiro
authors.forename: Jennifer
authors.initials: J
authors.lastname: Stapleton
authors.forename: Raul R
authors.initials: RR
authors.lastname: Gainetdinov
authors.forename: Marc G
authors.initials: MG
authors.lastname: Caron
authors.forename: Miguel A L
authors.initials: MA
authors.lastname: Nicolelis
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012895:Sleep, REM
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D004298:Dopamine