title: Positron emission tomography and [18F]BPA: a perspective application to assess tumour extraction of boron in BNCT.
abstract: Positron emission tomography (PET) has become a key imaging tool in clinical practice and biomedical research to quantify and study biochemical processes in vivo. Physiologically active compounds are tagged with positron emitters (e.g. (18)F, (11)C, (124)I) while maintaining their biological properties, and are administered intravenously in tracer amounts (10(-9)-10(-12)M quantities). The recent physical integration of PET and computed tomography (CT) in hybrid PET/CT scanners allows a combined anatomical and functional imaging: nowadays PET molecular imaging is emerging as powerful pharmacological tool in oncology, neurology and for treatment planning as guidance for radiation therapy. The in vivo pharmacokinetics of boron carrier for BNCT and the quantification of (10)B in living tissue were performed by PET in the late nineties using compartmental models based on PET data. Nowadays PET and PET/CT have been used to address the issue of pharmacokinetic, metabolism and accumulation of BPA in target tissue. The added value of the use of L-[(18)F]FBPA and PET/CT in BNCT is to provide key data on the tumour extraction of (10)B-BPA versus normal tissue and to predict the efficacy of the treatment based on a single-study patient analysis. Due to the complexity of a binary treatment like BNCT, the role of PET/CT is currently to design new criteria for patient enrolment in treatment protocols: the L-[(18)F]BPA/PET methodology could be considered as an important tool in newly designed clinical trials to better estimate the concentration ratio of BPA in the tumour as compared to neighbouring normal tissues. Based on these values for individual patients the decision could be made whether BNCT treatment could be advantageous due to a selective accumulation of BPA in an individual tumour. This approach, applicable in different tumour entities like melanoma, glioblastoma and head and neck malignancies, make this methodology as reliable prognostic and therapeutic indicator for patient undergoing BNCT.
authors.affiliation: Department of PET and Radiopharmaceutical Chemistry, C.N.R. Institute of Clinical Physiology, Pisa, Italy. luca.menichetti@ifc.cnr.it
authors.forename: L
authors.initials: L
authors.lastname: Menichetti
authors.forename: L
authors.initials: L
authors.lastname: Cionini
authors.forename: W A
authors.initials: WA
authors.lastname: Sauerwein
authors.forename: S
authors.initials: S
authors.lastname: Altieri
authors.forename: O
authors.initials: O
authors.lastname: Solin
authors.forename: H
authors.initials: H
authors.lastname: Minn
authors.forename: P A
authors.initials: PA
authors.lastname: Salvadori
mesh_terms: D001895:Boron / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001896:Boron Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D007554:Isotopes / Q000493:pharmacokinetics / Q000627:therapeutic use; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008545:Melanoma / Q000000981:diagnostic imaging / Q000556:secondary; D008954:Models, Biological; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D001896:Boron Compounds; D005462:Fluorine Radioisotopes; D007554:Isotopes; D011838:Radiation-Sensitizing Agents; C072915:4-borono-2-fluorophenylalanine; D010649:Phenylalanine; D001895:Boron