Chiral cobalt-catalyzed enantiomer-differentiating oxidation of racemic benzoins by using molecular oxygen as stoichiometric oxidant.
An efficient enantioselective oxidative reaction catalyzed by a chiral cobalt complex has been developed by using molecular oxygen as the stoichiometric oxidant (see scheme). The very mild reaction conditions of the catalytic system provide access to a wide range of benzoins (alpha-hydroxyketones) in high yield and excellent enantioselectivity (s (k(f)/k(s)) up to 47). This method is very versatile because the sole by-product of our oxidation process is water, which makes our system more eco-friendly and green.
Alamsetti
Santosh Kumar
SK
Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600036, India.
Muthupandi
Pandi
P
Sekar
Govindasamy
G
D001573:Benzoin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D007700:Kinetics; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D003035:Cobalt; D001573:Benzoin