A novel HLA-Cw*07 variant, HLA-Cw*0760, identified by sequence-based typing in a bone marrow donor.
We report the identification of the novel allele HLA-Cw*0760 that was found during confirmatory high-resolution sequence-based typing of a bone marrow donor. The Cw*0760 allele has two nucleotide changes from Cw*070101 at positions 341 and 343 in exon 2, resulting in two amino acid changes from Asp to Ala (codon 90: GAC-->GCC) and Gly to Arg (codon 91: GGG-->AGG).
Martínez-Martínez
L
L
Immunology Department, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.
González-Santesteban
C
C
Agustí-Martí
M
M
Pérez-Ranz
E
E
de la Calle-Martín
O
O
D000483:Alleles; D001483:Base Sequence; D001853:Bone Marrow / Q000276:immunology; D015236:HLA-C Antigens / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014019:Tissue Donors
D015236:HLA-C Antigens