title: [A case of advanced gastric cancer effectively treated with paclitaxel/S-1 as neoadjuvant chemotherapy].
abstract: We report a patient with advanced gastric cancer responding remarkably to neoadjuvant combination chemotherapy consisting of paclitaxel and S-1. The patient was a 65-year-old female who had large type 2 advanced gastric cancer with severe lymph node metastasis(cT3, cN3, cH0, cP0, cM0, cStage IV), treated with paclitaxel/S-1 as neoadjuvant chemotherapy. After the second course, according to UGI, gastroscope and CT findings, a significant tumor reduction was obtained. Distal gastrectomy with D2 nodal dissection were performed. The histological diagnosis was pT1, pN1, pStage IB. The histological effect of main tumor was judged to be Grade 2. The patient has now been in good health without a recurrence for 10 months after surgery. This case suggests that neoadjuvant chemotherapy with paclitaxel/ S-1 is a potential regimen for advanced gastric cancer.
authors.affiliation: Department of Surgery, Tosei General Hospital.
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Matsushita
authors.forename: Ichiro
authors.initials: I
authors.lastname: Honda
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kato
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Osamu
authors.initials: O
authors.lastname: Okochi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kobayashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Hattori
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takami
authors.forename: Ryouji
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Shigeomi
authors.initials: S
authors.lastname: Takeda
authors.forename: Akira
authors.initials: A
authors.lastname: Mizuno
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005773:Gastroscopy; D006801:Humans; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D017239:Paclitaxel / Q000627:therapeutic use*; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel