title: Evaluation of the cases with acute disseminated encephalomyelitis.
abstract: OBJECTIVE
  We aimed to describe the epidemiologic, clinical, laboratory features, neuroimaging, treatment, and outcome of children with acute disseminated encephalomyelitis in a cohort study.
  
  
  METHODS
  In this study, twelve children who were diagnosed as acute disseminated encephalomyelitis were reviewed retrospectively. All of the cases were reevaluated with systemic and neurological examinations, serologic tests, cerebrospinal fluid investigations, magnetic resonance imaging.
  
  
  RESULTS
  Their age ranged between 2.5 and 16 years. Five of the cases had initial infections. Patients presented most often with motor deficits (75%), secondly with loss of conscious (33%), and seizures (33%). Spinal fluid abnormalities occurred in 41.6%. Cranial, and spinal magnetic resonance imaging (MRI) revealed hyperintense signal changes mainly in basal ganglia and thalamus (58%), cortical and subcortical areas (33) in T2 weighted images. Myelitis was determined in two cases. Six patients were treated with steroid, and 3 were treated with intravenous immunoglobulin. Ten patients recovered completely. We observed relapse in one case and recurrence in two cases. These cases responded well to high dose intravenous prednisolone followed by oral prednisolone for 6 months.
  
  
  CONCLUSIONS
  Outlook recovery is generally good in acute disseminated encephalomyelitis. Recurrence and neurological deficits are rarely seen. Early treatment of prednisolone is one of the most important factors to determine the prognosis in this disease.
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, Ege University Medical School Bornova, 35100, Izmir, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Tosun
authors.forename: Gul
authors.initials: G
authors.lastname: Serdaroglu
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Polat
authors.forename: Hasan
authors.initials: H
authors.lastname: Tekgul
authors.forename: Sarenur
authors.initials: S
authors.lastname: Gokben
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D038524:Diffusion Magnetic Resonance Imaging; D042241:Early Diagnosis; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009460:Neurologic Examination / Q000379:methods*; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D013129:Spinal Puncture / Q000379:methods*; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous