title: Intraventricular metaplastic meningioma in a child: case report and review of the literature.
abstract: Childhood meningiomas are rare and display important differences from adult forms. We report the first case of an intraventricular metaplastic meningioma arising in a child. A 7-year-old female underwent resection of an enhancing tumor arising within the left lateral ventricle. It was composed of monomorphic cells embedded within an abundant myxoid stroma. The cells demonstrated epithelial membrane antigen and vimentin immunoreactivity. Ultrastructural analysis demonstrated intermediate filaments, complex intercellular interdigitations and desmosomes, and a diagnosis of myxoid (metaplastic) meningioma was rendered. This case reflects the higher incidence of intraventricular meningiomas in childhood and greater incidence of intraventricular meningiomas in the left lateral ventricle. Recognition of the grade I myxoid meningioma in this case is paramount since chordoid meningiomas, which share similar histologic features, are of a higher grade and worse prognosis.
authors.affiliation: Stanford University Medical Center, Stanford, California 94305, USA. mohanpal@comcast.net
authors.forename: Mohanpal Singh
authors.initials: MS
authors.lastname: Dulai
authors.forename: Abdul-Majid
authors.initials: AM
authors.lastname: Khan
authors.forename: Michael S B
authors.initials: MS
authors.lastname: Edwards
authors.forename: Hannes
authors.initials: H
authors.lastname: Vogel
mesh_terms: D002551:Cerebral Ventricle Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D020547:Lateral Ventricles / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011859:Radiography