Vasculitis syndromes: LAMP-2 illuminates pathogenesis of ANCA glomerulonephritis.
The discovery that antibodies to a bacterial antigen can cross-react with a mammalian protein to cause pauci-immune necrotizing and crescentic glomerulonephritis opens up new possibilities for the diagnosis and treatment of this condition.
Bosch
Xavier
X
Department of Internal Medicine, Hospital Clinic, Institut d'Investigació Biomédica August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. xavbosch@clinic.ub.es
Mirapeix
Eduard
E
D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D052119:Lysosomal-Associated Membrane Protein 2; D051907:Lysosomal Membrane Proteins / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; C497811:LAMP2 protein, human; D052119:Lysosomal-Associated Membrane Protein 2; D051907:Lysosomal Membrane Proteins