title: Evaluation of efficacy and safety of anterior corpus callosotomy with keyhole in refractory seizures.
abstract: OBJECTIVE
  This study was conducted to evaluate the efficacy and safety of anterior corpus callosotomy with a keyhole approach on refractory seizures and to evaluate this procedure for drop attacks (DAs) and generalized tonic-clonic seizures (GTCSs).
  
  
  METHODS
  All refractory seizure patients underwent anterior corpus callosotomy (n=31) without other epilepsy surgery. Seizure response and procedure complications were evaluated.
  
  
  RESULTS
  Seizure types included GTCS (n=26), and atonic or tonic seizures with DA (n=9). In GTCS patients, 84.6% had >or=50% decrease in seizure frequency, and 61.5% had >or=80% reduction. In DA patients, 77.8% had >or=50% decrease in seizure frequency, and 55.6% had >or=80% reduction. There were no statistically significant differences between the groups in final efficacy. Overall complication rate for corpus callosotomy was 12.9%, the permanent complication rate was 3.2%.
  
  
  CONCLUSIONS
  Anterior corpus callosotomy with a keyhole approach produces highly favorable outcomes for both GTCS and atonic or tonic seizures with a low risk for complications.
authors.affiliation: Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ping
authors.forename: Xu
authors.initials: X
authors.lastname: Ji-Wen
authors.forename: Wang
authors.initials: W
authors.lastname: Gui-Song
authors.forename: Zhou
authors.initials: Z
authors.lastname: Hong-Yu
authors.forename: Tian
authors.initials: T
authors.lastname: Xin
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000601:surgery*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000473:pathology* / Q000601:surgery*; D050812:Split-Brain Procedure / Q000009:adverse effects* / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult