Cyclooxygenase-2 inhibitors and other nonsteroidal anti-inflammatory drugs in the treatment of musculoskeletal conditions.
Selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat a variety of musculoskeletal conditions. The efficacy of these medications has been proved, although the risks have not been clearly delineated. Nonselective NSAIDs are associated with gastrointestinal, renal, and hematologic complications. The risks of using selective NSAIDs may include cardiovascular adverse events. The most appropriate agent should be chosen by considering the possible complications as well as the patient's risk profile.
Austin
Matthew S
MS
Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Abdul-Hadi
Omar
O
Parvizi
Javad
J
Viscusi
Eugene R
ER
Einhorn
Thomas
T
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001842:Bone and Bones / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D041981:Gastrointestinal Tract / Q000187:drug effects; D006801:Humans; D009140:Musculoskeletal Diseases / Q000188:drug therapy*; D010149:Postoperative Pain / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors