title: Changing prevalence of upper gastrointestinal disease in 28 893 Koreans from 1995 to 2005.
abstract: OBJECTIVE
  Changes in the pattern of gastrointestinal diseases in a population tend to be influenced by changes in diet and lifestyle. Shifts in gastrointestinal disease from 1995 to 2005 in Korea were evaluated, retrospectively.
  
  
  METHODS
  Seventeen nationwide medical centers participated in this study. The cross-sectional review of endoscopic findings in 28 893 patients included 8441 patients from 1995, 10 350 patients from 2000, and 10 102 patients from 2005.
  
  
  RESULTS
  The prevalence of reflux esophagitis increased from 1.8% in 1995 to 5.9% in 2000 and 9.1% in 2005 (P<0.001, the P value was only for the comparison between 1995 and 2005, the followings were as same). The prevalence of peptic ulcer diseases was 18.0% in 1995, 19.1% in 2000, and 20.2% in 2005 (P<0.001). Although no significant differences were noted in duodenal ulcers (8.4, 8.7, and 8.2%, P=0.449), gastric ulcers showed an increasing trend (9.6, 10.5, and 12.0%, P<0.001). The prevalence of gastric cancer increased from 3.4% in 1995 to 4.5% in 2000 (P<0.001), but then decreased to 2.4% in 2005 (P<0.001). The incidence of advanced gastric cancer was 2.5, 3.2, and 1.3%, respectively (P<0.001), and that of early gastric cancer remained constant with rates of 0.8%, 1.3, and 1.1%, respectively (P=0.056).
  
  
  CONCLUSIONS
  The cross-sectional review of data collected in 1995, 2000, and 2005 showed an increase in reflux esophagitis and peptic ulcer diseases. Meanwhile, the prevalence of gastric cancer increased until 2000, but decreased in 2005.
authors.affiliation: Department of Internal Medicine, Catholic University of Korea, Korea.
authors.forename: Jin Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Sang Gyun
authors.initials: SG
authors.lastname: Kim
authors.forename: Nayoung
authors.initials: N
authors.lastname: Kim
authors.forename: Jae Gyu
authors.initials: JG
authors.lastname: Kim
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Shin
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Jae Kyu
authors.initials: JK
authors.lastname: Sung
authors.forename: Chang Heon
authors.initials: CH
authors.lastname: Yang
authors.forename: Ki-Nam
authors.initials: KN
authors.lastname: Shim
authors.forename: Seun Ja
authors.initials: SJ
authors.lastname: Park
authors.forename: Joon Yong
authors.initials: JY
authors.lastname: Park
authors.forename: Gwang Ho
authors.initials: GH
authors.lastname: Baik
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Lee
authors.forename: Jong Jae
authors.initials: JJ
authors.lastname: Park
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Hong
authors.forename: Gin Hyug
authors.initials: GH
authors.lastname: Lee
authors.forename: Geom Seog
authors.initials: GS
authors.lastname: Seo
authors.forename: Sang In
authors.initials: SI
authors.lastname: Lee
authors.forename: Hyun Chae
authors.initials: HC
authors.lastname: Jung
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D005767:Gastrointestinal Diseases / Q000453:epidemiology*; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors