title: The potential role of targeted therapies in the management of neuroendocrine tumours.
abstract: The management of gastro-entero-pancreatic neuroendocrine tumours is evolving thanks to new TNM-classification, diagnostic and staging procedures and new therapeutic options. Targeting new pathways, mostly angiogenesis, development of novel agents is under way and opens new perspectives in controlling the evolution of these tumours and possibly changing their management. In parallel, new functional imaging techniques and biomolecular markers will be developed to provide adequate tools for the assessment of tumor response according to therapeutic intervention on angiogenesis, proliferation and apoptosis. This paper reviews the potential role of new investigational targeted agents which will likely become the backbone of future therapy of neuroendocrine tumors.
authors.affiliation: Department Gastrointestinal Oncology Unit, Erasme University Hospital, Anderlecht.
authors.forename: G
authors.initials: G
authors.lastname: Verset
authors.forename: I
authors.initials: I
authors.lastname: Borbath
authors.forename: T
authors.initials: T
authors.lastname: Delaunoit
authors.forename: P
authors.initials: P
authors.lastname: Demetter
authors.forename: G
authors.initials: G
authors.lastname: Demolin
authors.forename: A
authors.initials: A
authors.lastname: Hendlisz
authors.forename: P
authors.initials: P
authors.lastname: Pattyn
authors.forename: S
authors.initials: S
authors.lastname: Pauwels
authors.forename: M
authors.initials: M
authors.lastname: Peeters
authors.forename: G
authors.initials: G
authors.lastname: Roeyen
authors.forename: E
authors.initials: E
authors.lastname: Van Cutsem
authors.forename: Ph
authors.initials: P
authors.lastname: Van Hootegem
authors.forename: C
authors.initials: C
authors.lastname: Verslype
authors.forename: J L
authors.initials: JL
authors.lastname: Van Laethem
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D007414:Intestinal Neoplasms / Q000188:drug therapy*; D018358:Neuroendocrine Tumors / Q000188:drug therapy*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors