title: Tubular proteinuria and glomerular filtration 6 years after puumala hantavirus-induced acute interstitial nephritis.
abstract: OBJECTIVE
  We previously found increased urinary protein excretion, glomerular filtration rate (GFR) and blood pressure in a retrospective analysis of patients with previous nephropathia epidemica (NE). Here, we evaluated the long-term outcome after NE in a prospectively recruited patient group.
  
  
  METHODS
  Proteinuria, GFR and ambulatory 24-hour blood pressure were assessed 4-7 years (mean 6) after acute NE in 37 patients, and these values were compared to those from 38 seronegative controls.
  
  
  RESULTS
  Six years after NE, the prevalence of elevated urinary alpha(1)-microglobulin excretion was higher in the patients than controls (9/35 vs. 1/38; p = 0.005). The patients also had higher urinary protein excretion (0.17 +/- 0.05 vs. 0.14 +/- 0.04 g/day; p = 0.006), GFR (119 +/- 19 vs. 109 +/- 14 ml/min/1.73 m(2); p = 0.016) and mean systolic (123 +/- 11 vs. 117 +/- 9 mm Hg; p = 0.012), nighttime systolic (109 +/- 11 vs. 100 +/- 9 mm Hg; p = 0.001) and nighttime diastolic blood pressure (70 +/- 7 vs. 66 +/- 7 mm Hg; p = 0.035) than the controls.
  
  
  CONCLUSIONS
  These results confirm our previous findings of a higher prevalence of tubular proteinuria and increased urinary protein excretion, GFR and systolic blood pressure 6 years after acute NE.
authors.affiliation: Department of Internal Medicine, Central Hospital of Jyvaskyla, Jyvaskyla, Finland. marja.miettinen@ksshp.fi
authors.forename: Marja H
authors.initials: MH
authors.lastname: Miettinen
authors.forename: Satu M
authors.initials: SM
authors.lastname: Makela
authors.forename: Ilpo O
authors.initials: IO
authors.lastname: Ala-Houhala
authors.forename: Heini S
authors.initials: HS
authors.lastname: Huhtala
authors.forename: Tiit
authors.initials: T
authors.lastname: Koobi
authors.forename: Antti I
authors.initials: AI
authors.lastname: Vaheri
authors.forename: Amos I
authors.initials: AI
authors.lastname: Pasternack
authors.forename: Ilkka H
authors.initials: IH
authors.lastname: Porsti
authors.forename: Jukka T
authors.initials: JT
authors.lastname: Mustonen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005919:Glomerular Filtration Rate; D006480:Hemorrhagic Fever with Renal Syndrome / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000473:pathology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000175:diagnosis* / Q000209:etiology*; D011507:Proteinuria / Q000175:diagnosis* / Q000209:etiology*