Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging.
Nanophotothermolysis with long laser pulses for treatment of scattered cancer cells and their clusters is introduced with the main focus on real-time monitoring of temperature dynamics inside and around individual cancer cells labeled with carbon nanotubes. This technique utilizes advanced time- and spatially-resolved thermal radiometry imaging for the visualization of laser-induced temperature distribution in multiple-point absorbing targets. The capability of this approach was demonstrated for monitoring of thermal effects under long laser exposure (from millisecond to seconds, wavelength 1,064 nm, maximum power 1 W) of cervical cancer HeLa cells labeled with carbon nanotubes in vitro. The applications are discussed with a focus on the nanophotothermolysis of small tumors, tumor margins, or micrometastases under the guidance of near-IR and microwave radiometry.
Biris
Alexandru S
AS
University of Arkansas at Little Rock, Applied Science Department, Nanotechnology Center, Little Rock, Arkansas 72204, USA. asbiris@ualr.edu
Boldor
Dorin
D
Palmer
Jason
J
Monroe
William T
WT
Mahmood
Meena
M
Dervishi
Enkeleda
E
Xu
Yang
Y
Li
Zhongrui
Z
Galanzha
Ekaterina I
EI
Zharov
Vladimir P
VP
D017209:Apoptosis / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays / Q000627:therapeutic use; D037742:Nanotubes, Carbon; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*; D013055:Spectrophotometry, Infrared / Q000379:methods*; D013817:Thermography / Q000379:methods*; D016896:Treatment Outcome
D037742:Nanotubes, Carbon