Of flaky tails and itchy skin.
A new study defines the flaky tail mouse as a model for human atopic dermatitis caused by a null mutation in the gene encoding filaggrin, a key component of the epidermal barrier. Research in these mice will help explain how a disrupted barrier contributes to the pathogenesis of atopic dermatitis and to asthma arising in the context of atopic skin disease.
Vercelli
Donata
D
D000818:Animals; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000378:metabolism; D000091344:Filaggrin Proteins; D014644:Genetic Variation; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism; D051379:Mice; D010641:Phenotype
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins