[Effects of systemic administration of glutamate antibodies on acute convulsive reaction of C57B1/6 mice].
The impact of a single intraperitoneal injection of antibodies to glutamate (AG) on acute generalized epileptic activity provoked by systemic introduction of pentilentetrasol was studied in C57B1/6 mice. It was found that AG in doses 10, 25 and 50 mg/kg 1.5 and 24 hours after AG injection produced an anti-epileptic action by raising thresholds of clonic convultions and tonic phase of convultions with lethal outcome and by extending a latent period of their appearance. Later (30 hours after antibodies introduction in a dose 25 mg/kg) AG had no effects on the convulsive reaction thresholds, 48 hours after AG injection they produced a proepileptic effect by lowering the threshold of a clonic convulsion phase.
Kuznetsova
L V
LV
Karpova
M N
MN
Vetrilé
L A
LA
Klishina
N Iu
NIu
Trekova
N A
NA
D000208:Acute Disease; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000276:immunology*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010433:Pentylenetetrazole; D012640:Seizures / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D013997:Time Factors
D000911:Antibodies, Monoclonal; D000927:Anticonvulsants; D018698:Glutamic Acid; D010433:Pentylenetetrazole