title: Survival analysis of one versus two treatments of local delivery cisplatin in a biodegradable polymer for canine osteosarcoma.
abstract: The purpose of this study was to evaluate one versus two doses of local delivery cisplatin in a biodegradable polymer (OPLA-Pt) for the treatment of osteosarcoma (OSA) after amputation in dogs. Medical records were reviewed retrospectively, and 105 dogs were included in the study; 39% of dogs received one treatment (surgical implantation) of OPLA-Pt and 61% of dogs received two treatments of OPLA-Pt after amputation. Administration of two doses of OPLA-Pt did not have a significant effect on disease-free interval or survival time compared to one dose. The anatomic site of the tumour was identified as a prognostic factor, and dogs with proximal humeral OSA had the shortest disease-free interval and survival times. There was no advantage to giving a second dose of local delivery cisplatin following amputation for the treatment of OSA in dogs.
authors.affiliation: Department of Radiological and Surgical Sciences, University of California, Davis, CA 95616, USA. mmehl@ucdavis.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Mehl
authors.forename: B
authors.initials: B
authors.lastname: Seguin
authors.forename: W S
authors.initials: WS
authors.lastname: Dernell
authors.forename: M
authors.initials: M
authors.lastname: Lafferty
authors.forename: P H
authors.initials: PH
authors.lastname: Kass
authors.forename: S J
authors.initials: SJ
authors.lastname: Withrow