title: Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.
abstract: BACKGROUND
  Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood.
  
  
  RESULTS
  Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-ras(G12D) and p53(R172H). We identified 2,209 genes that were differentially expressed in distant metastases relative to matched lung tumors. Mining of publicly available data bases revealed this expression signature in a subset of NSCLC patients who had a poorer prognosis than those without the signature.
  
  
  CONCLUSIONS
  These findings provide evidence that K-ras(G12D); p53(R172H) mice recapitulate features of human NSCLC metastasis and will provide a useful platform on which to study the biologic basis for lung adenocarcinoma metastasis and its prevention by novel agents.
authors.affiliation: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, United States of America.
authors.forename: Don L
authors.initials: DL
authors.lastname: Gibbons
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.forename: Chad J
authors.initials: CJ
authors.lastname: Creighton
authors.forename: Shuling
authors.initials: S
authors.lastname: Zheng
authors.forename: Dror
authors.initials: D
authors.lastname: Berel
authors.forename: Yanan
authors.initials: Y
authors.lastname: Yang
authors.forename: Maria Gabriela
authors.initials: MG
authors.lastname: Raso
authors.forename: Diane D
authors.initials: DD
authors.lastname: Liu
authors.forename: Ignacio I
authors.initials: II
authors.lastname: Wistuba
authors.forename: Guillermina
authors.initials: G
authors.lastname: Lozano
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Kurie
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000473:pathology; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D011905:Genes, ras / Q000235:genetics; D020022:Genetic Predisposition to Disease; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D051379:Mice; D020125:Mutation, Missense; D009362:Neoplasm Metastasis / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D016159:Tumor Suppressor Protein p53