title: Hepatocellular adenoma in advanced-stage fatty liver disease.
abstract: Hepatocellular adenomas are defined as benign hepatocellular neoplasms occurring in otherwise near normal liver and adenomatosis as 10 or more such lesions. We present a case of a 45-year-old man with radiological adenomatosis, histologically confirmed with resection of one lesion, arising within advanced-stage nonalcoholic fatty liver disease (nearly cirrhotic). Hepatocellular adenomas have recently been divided into four categories and the lesion in the present case had morphologic and immunohistochemical features of an inflammatory hepatocellular adenoma. These findings demonstrate that, in contrast to the current dogma, nodules within advanced-stage liver disease may rarely be best classified as adenomas. This should be considered in the radiological differential diagnosis when assessing a patient's suitability for transplantation.
authors.affiliation: Department of Histopathology, Royal Free and University College Medical School, London, UK. jgwatkins@gmail.com
authors.forename: Jennifer
authors.initials: J
authors.lastname: Watkins
authors.forename: Charles
authors.initials: C
authors.lastname: Balabaud
authors.forename: Paulette
authors.initials: P
authors.lastname: Bioulac-Sage
authors.forename: Dinesh
authors.initials: D
authors.lastname: Sharma
authors.forename: Amar
authors.initials: A
authors.lastname: Dhillon
mesh_terms: D018248:Adenoma, Liver Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011859:Radiography