Oxidative stress and insulin resistance: the coronary artery risk development in young adults study.
OBJECTIVE
Although cumulative evidence suggests that increased oxidative stress may lead to insulin resistance in vivo or in vitro, community-based studies are scarce. This study examined the longitudinal relationships of oxidative stress biomarkers with the development of insulin resistance and whether these relationships were independent of obesity in nondiabetic young adults.


METHODS
Biomarkers of oxidative stress (F(2)-isoprostanes [F(2)Isop] and oxidized LDL [oxLDL]), insulin resistance (the homeostasis model assessment of insulin resistance [HOMA-IR]), and various fatness measures (BMI, waist circumference, and estimated percent fat) were obtained in a population-based observational study (Coronary Artery Risk Development in Young Adults) and its ancillary study (Young Adult Longitudinal Trends in Antioxidants) during 2000-2006.


RESULTS
There were substantial increases in estimated mean HOMA-IR over time. OxLDL and F(2)Isop showed little association with each other. Mean evolving HOMA-IR increased with increasing levels of oxidative stress markers (P < 0.001 for oxLDL and P = 0.06 for F(2)Isop), measured in 2000-2001. After additional adjustment for adiposity, a positive association between oxLDL and HOMA-IR was strongly evident, whereas the association between F(2)Isop and HOMA-IR was not.


CONCLUSIONS
We observed positive associations between each of two oxidative stress markers and insulin resistance. The association with oxidized LDL was independent of obesity, but that with F(2)Isop was not.
Park
Kyong
K
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Gross
Myron
M
Lee
Duk-Hee
DH
Holvoet
Paul
P
Himes
John H
JH
Shikany
James M
JM
Jacobs
David R
DR
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D044383:Black People / Q000706:statistics & numerical data; D015992:Body Mass Index; D015331:Cohort Studies; D003327:Coronary Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008019:Life Style; D008077:Lipoproteins, LDL / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D055105:Waist Circumference; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult
D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein