Ubiquitination - a bacterial effector's ticket to ride.
Ubiquitination has many important cellular functions, including regulation of plasma membrane endocytosis. In their recent article in Cell, Patel et al. (2009) show that the activity of the multifunctional Salmonella virulence protein SopB is controlled by ubiquitin-dependent delivery from the plasma membrane to the Salmonella-containing vacuole.
Thomas
Mair
M
Department of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK.
Holden
David W
DW
D001426:Bacterial Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry; D008954:Models, Biological; D012475:Salmonella / Q000502:physiology*; D054875:Ubiquitination; D014617:Vacuoles / Q000737:chemistry; D037521:Virulence Factors / Q000378:metabolism*
D001426:Bacterial Proteins; D037521:Virulence Factors; C489224:SopB protein, Salmonella