Photodynamic therapy for the treatment of buccal candidiasis in rats.
The study objective was to evaluate the effects of photodynamic therapy on buccal candidiasis in rats. After experimental candidiasis had been induced on the tongue dorsum, 72 rats were distributed into four groups according to treatment: treated with laser and methylene blue photosensitizer (L+P+); treated only with laser (L+P-); treated only with photosensitizer (L--P+); not treated with laser or photosensitizer (L-P-). The rats were killed immediately, 1 day, or 5 days after treatment, for microscopic analysis of the tongue dorsum. Observation verified that the photodynamic therapy group (L+P+) exhibited fewer epithelial alterations and a lower chronic inflammatory response than the L-P- group. The group L+P- presented more intense epithelial alterations and chronic inflammatory response than the remaining groups. The L-P+ group showed tissue lesions similar to those of the L-P- group. In conclusion, rats treated with photodynamic therapy developed more discrete candidiasis lesions than did the remaining groups.
Junqueira
Juliana Campos
JC
Department of Biosciences and Oral Diagnosis, School of Dentistry of São José dos Campos, São Paulo State University (UNESP), São Paulo, Brazil. juliana@fosjc.unesp.br
Martins
Joyce da Silva
Jda S
Faria
Raquel Lourdes
RL
Colombo
Carlos Eduardo Dias
CE
Jorge
Antonio Olavo Cardoso
AO
D000818:Animals; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification / Q000528:radiation effects; D002180:Candidiasis, Oral / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology / Q000532:radiotherapy; D002610:Cheek; D028022:Low-Level Light Therapy; D008751:Methylene Blue / Q000627:therapeutic use; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014059:Tongue
D017319:Photosensitizing Agents; D008751:Methylene Blue