title: Effect of intracanal corticosteroids on healing of replanted dog teeth after extended dry times.
abstract: This study investigated the effect of potent intracanal corticosteroids on periodontal healing of replanted avulsed teeth and evaluated the systemic absorption of these corticosteroids. Sixty-seven extracted dog premolar roots were randomly assigned to one of the following groups: groups 1-3 filled with gutta-percha and replanted immediately and after 40 and 60 minutes, respectively; groups 4 and 5 filled with 0.05% clobetasol; and groups 6 and 7 filled with 0.05 % fluocinonide. Groups 4 and 6 were replanted after 40 minutes and groups 5 and 7 after 60 minutes. After 4 months, roots were evaluated histologically for signs of periodontal healing. Roots treated with clobetasol and fluocinonide healed more favorably than roots filled with gutta-percha and were different from each other at 60 minutes. No change in the systemic corticosteroid blood concentration was observed in any group. Corticosteroids were efficacious in the beagle model as intracanal medicaments for promoting favorable postavulsion periodontal healing.
authors.affiliation: Department of Endodontics, University of North Carolina, Chapel Hill, North Carolina 28211, USA. anna.endo@gmail.com
authors.forename: Anna
authors.initials: A
authors.lastname: Kirakozova
authors.forename: Fabricio B
authors.initials: FB
authors.lastname: Teixeira
authors.forename: Alice E
authors.initials: AE
authors.lastname: Curran
authors.forename: Fang
authors.initials: F
authors.lastname: Gu
authors.forename: Peter Z
authors.initials: PZ
authors.lastname: Tawil
authors.forename: Martin
authors.initials: M
authors.lastname: Trope
mesh_terms: D000818:Animals; D001641:Bicuspid / Q000293:injuries; D002990:Clobetasol / Q000097:blood / Q000627:therapeutic use*; D003890:Desiccation; D004195:Disease Models, Animal; D004285:Dogs; D005447:Fluocinonide / Q000097:blood / Q000627:therapeutic use*; D005899:Glass Ionomer Cements / Q000627:therapeutic use; D005938:Glucocorticoids / Q000097:blood / Q000627:therapeutic use*; D006171:Gutta-Percha / Q000627:therapeutic use; D010513:Periodontal Ligament / Q000187:drug effects*; D011897:Random Allocation; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D012391:Root Resorption / Q000517:prevention & control; D013997:Time Factors; D014084:Tooth Avulsion / Q000188:drug therapy / Q000628:therapy*; D014090:Tooth Replantation; D014092:Tooth Root / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects; D015035:Zinc Oxide-Eugenol Cement / Q000627:therapeutic use
chemical_list: D005899:Glass Ionomer Cements; D005938:Glucocorticoids; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C110713:fuji IX; D005447:Fluocinonide; C095719:Roth's 811 sealer; D006171:Gutta-Percha; D002990:Clobetasol