The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.
OBJECTIVE
Previous studies have demonstrated that the PRL -1149 T (minor) allele decreases prolactin expression and may be associated with autoimmune disease. The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility.


METHODS
We examined the association between PRL -1149 G/T and RA risk in 4 separate study populations, consisting of a total of 3,405 RA cases and 4,111 controls of self-reported white European ancestry. Samples were genotyped using 1 of 3 genotyping platforms, and strict quality control metrics were applied. We tested for association using a 2-tailed Cochran-Mantel-Haenszel additive, fixed-effects model.


RESULTS
In the individual populations, odds ratios (ORs) for an association between PRL -1149 T and RA risk ranged from 0.80 to 0.97. In a joint meta-analysis across all 4 populations, the OR for an association between PRL -1149 T and RA risk was 0.90 (95% confidence interval 0.84-0.96, P=0.001).


CONCLUSIONS
Our findings indicate a possible association between the PRL -1149 T allele and decreased RA risk. The effect size is small but similar to ORs for other genetic polymorphisms associated with complex traits, including RA.
Lee
Yvonne C
YC
Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. ylee9@partners.org
Raychaudhuri
Soumya
S
Cui
Jing
J
De Vivo
Immaculata
I
Ding
Bo
B
Alfredsson
Lars
L
Padyukov
Leonid
L
Costenbader
Karen H
KH
Seielstad
Mark
M
Graham
Robert R
RR
Klareskog
Lars
L
Gregersen
Peter K
PK
Plenge
Robert M
RM
Karlson
Elizabeth W
EW
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011388:Prolactin / Q000235:genetics*
D011388:Prolactin