title: Cyclic glycopeptidomimetics through a versatile sugar-based scaffold.
abstract: Cyclic peptidomimetics are attracting structures to obtain a distinct, bioactive conformation. Even more attractive are sugar-containing cyclic peptidomimetics which present turn structures induced by the pyranose ring when incorporated in cyclic peptides. The use of a new and versatile saccharidic scaffold to achieve sugar-based peptidomimetics is here reported together with the successful synthesis of diastereomerically pure cyclic SAA peptidomimetics 15 and 16.
authors.affiliation: Menarini Ricerche SpA, Firenze, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Altamura
authors.forename: Elisa
authors.initials: E
authors.lastname: Dragoni
authors.forename: Angela Simona
authors.initials: AS
authors.lastname: Infantino
authors.forename: Laura
authors.initials: L
authors.lastname: Legnani
authors.forename: Steve B
authors.initials: SB
authors.lastname: Ludbrook
authors.forename: Gloria
authors.initials: G
authors.lastname: Menchi
authors.forename: Lucio
authors.initials: L
authors.lastname: Toma
authors.forename: Cristina
authors.initials: C
authors.lastname: Nativi
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002241:Carbohydrates; D006020:Glycopeptides; D039041:Integrin alpha4beta1; D010456:Peptides, Cyclic