title: Regeneration of ischemic heart using hyaluronic acid-based injectable hydrogel.
abstract: An injectable hydrogel was applied to regenerate a myocardial infarction and functional recovery of the heart. A myocardial infarction was induced in rat by circumflex artery ligation. A hyaluronic acid-based hydrogel was injected into the epicardium of the infarcted area. Then, cardiac functions and regeneration of the myocardium in sham-operated (SHAM), myocardial infarction (MI), and gel-injected group (GEL) (n = 6) were evaluated 4 weeks after the injection. Measurements of the thickness of the wall showed that the thickness in the GEL group increased by up to 200% compared with that in the MI group (p < 0.001). The infarcted area of the left ventricular in the GEL group decreased by 53% compared with the MI group (p < 0.001). The number of arterioles and capillaries in the border zone of the GEL group increased by 152% and 148%, whereas the apoptotic index decreased by 42% (p < 0.05). Measurement of the heart functions, such as ejection fraction, arterial elastance (Ea), dP/dt max, and dP/dt min, indicated that the injection of a hydrogel significantly facilitated the functional recovery compared with the MI group. Because of its simplicity, easy applicability, and a great regenerating potential, this injectable hydrogel promises as a treatment for myocardial infarction.
authors.affiliation: Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul, Korea.
authors.forename: So Jeong
authors.initials: SJ
authors.lastname: Yoon
authors.forename: Yong Hu
authors.initials: YH
authors.lastname: Fang
authors.forename: Choon Hak
authors.initials: CH
authors.lastname: Lim
authors.forename: Bum Shik
authors.initials: BS
authors.lastname: Kim
authors.forename: Ho Sung
authors.initials: HS
authors.lastname: Son
authors.forename: Yongdoo
authors.initials: Y
authors.lastname: Park
authors.forename: Kyung
authors.initials: K
authors.lastname: Sun
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D006352:Heart Ventricles / Q000378:metabolism / Q000473:pathology; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D008297:Male; D008422:Materials Testing; D015394:Molecular Structure; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006820:Hyaluronic Acid