Antioxidants intake and dry eye syndrome: a crossover, placebo-controlled, randomized trial.
To assess whether an orally administered antioxidant dietary supplement could improve the objective clinical signs and alleviate the subjective symptoms of dry eye syndrome.



Twenty-four subjects diagnosed with dry eye syndrome were randomized in a crossover, double-blind, controlled, randomized study to receive a placebo or an antioxidants combination (Oxybiane) for 12 weeks. In all subjects, break-up time (BUT) test, Schirmer test, ocular symptoms (sore eyes, burning, itching, sensation of foreign object in the eye, photophobia, sticky eyes, and redness), visual comfort, and general well-being were evaluated weekly.



After 12 weeks of supplementation with Oxybiane, both the BUT scores (27.3%+/-8.4% with Oxybiane versus 3.61%+/-4.3% with the placebo, p=0.017) and the Schirmer scores (26.9%+/-14.2% with Oxybiane versus -4.7%+/-3.4% with the placebo, p=0.037) were significantly increased. A significantly improvement was also observed considering subjective clinical symptoms such as burning (p=0.031), itching (p=0.027), sensation of foreign body in eye (p=0.030), and redness (p=0.043). CONCLUSIONS. Supplementation with oral antioxidants can improve both tear stability and quantity but also subjective clinical signs.
Drouault-Holowacz
Sophie
S
PiLeJe, Paris - France. s.holowacz@pileje.com
Bieuvelet
Séverine
S
Burckel
André
A
Rigal
Danièle
D
Dubray
Claude
C
Lichon
Jean-Louis
JL
Bringer
Paul
P
Pilon
Francois
F
Chiambaretta
Frédéric
FR
D000284:Administration, Oral; D000975:Antioxidants / Q000008:administration & dosage*; D002214:Capsules; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013666:Tears / Q000502:physiology; D016896:Treatment Outcome
D000975:Antioxidants; D002214:Capsules