title: Investigation of the sensitivity of a cross-polarized light visualization system to detect subclinical erythema and dryness in women with vulvovaginitis.
abstract: OBJECTIVE
  An enhanced visualization technique using polarized light (Syris v600 enhanced visualization system; Syris Scientific LLC, Gray, ME) detects surface and subsurface ( approximately 1 mm depth) inflammation. We sought to compare the Syris v600 system with unaided visual inspection and colposcopy of the female genitalia.
  
  
  METHODS
  Erythema and dryness of the vulva, introitus, vagina, and cervix were visualized and scored by each method in patients with and without vulvitis.
  
  
  RESULTS
  Subsurface visualization was more sensitive in detecting genital erythema and dryness at all sites whether or not symptoms were present. Subsurface inflammation of the introitus, vagina, and cervix only was detected uniquely in women with vulvar vestibulitis syndrome (VVS). A subset of women presenting with VVS exhibited subclinical inflammation of the vulva vestibule and vagina (designated VVS/lichen sclerosus subgroup).
  
  
  CONCLUSIONS
  Enhanced visualization of the genital epithelial subsurface with cross-polarized light may assist in diagnosing subclinical inflammation in vulvar conditions heretofore characterized as sensory syndromes.
authors.affiliation: Feminine Clinical Sciences, The Procter & Gamble Company, Cincinnati, OH 45224, USA. Farage.m@pg.com
authors.forename: Miranda A
authors.initials: MA
authors.lastname: Farage
authors.forename: Mukul
authors.initials: M
authors.lastname: Singh
authors.forename: William J
authors.initials: WJ
authors.lastname: Ledger
mesh_terms: D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000473:pathology; D003127:Colposcopy; D003944:Diagnostic Techniques, Obstetrical and Gynecological; D004890:Erythema / Q000175:diagnosis; D005260:Female; D006801:Humans; D008027:Light; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014621:Vagina / Q000473:pathology; D014844:Vulva / Q000473:pathology; D014848:Vulvovaginitis / Q000175:diagnosis* / Q000473:pathology