title: Early hypothermia in severely injured trauma patients is a significant risk factor for multiple organ dysfunction syndrome but not mortality.
abstract: OBJECTIVE
  To evaluate the relationship of early hypothermia to multiple organ failure and mortality in a prospectively-collected database of severely injured trauma patients.
  
  
  METHODS
  This prospective observational study was performed at 7 level I trauma centers over a 16-month period. Severely injured trauma patients with signs of hypoperfusion (eg, base deficit, hypotension) and need for blood transfusion during their early hospital course were followed for 24 hours with near infrared spectroscopy-derived tissue oxygen saturation (StO2) and other variables for 28 days to evaluate outcomes including multiple organ dysfunction syndrome (MODS) and death. Early hypothermia was defined as the presence of a temperature <35°C [corrected] anytime within the first 6 hours of hospitalization. Comparisons between groups were made using the Wilcoxon Two-Sample test for continuous variables and either the Fisher exact or chi2 test for categorical variables. Multivariate logistic regression was utilized to understand the effect of hypothermia on outcome (MODS and mortality).
  
  
  RESULTS
  Hypothermia was very common in this cohort of patients, present in 43% of patients enrolled (155/359). Hypothermic patients were 3 times more likely than normothermic patients to develop MODS (21% vs. 9%, P = 0.003). Hypothermic patients did not have an increased incidence of mortality (16% vs. 12%, P= 0.2826). Base deficit in hypothermic patients did not discriminate between patients who did or did not develop MODS (9.8 +/- 4.6 mEq/L vs. 9.4 +/- 4.4 mEq/L). In contrast, base deficit in hypothermic patients discriminated with respect to mortality (14.6 +/- 7.2 mEq/L versus 9.5 +/- 4.5 mEq/L; P 0.0021), but this effect was not observed in normothermic patients [corrected]. Significant predictors of MODS using multivariate analysis included minimum StO2 (P= 0.0014) and hypothermia (P = 0.0371). Predictors for mortality using multivariate analysis included minimum StO2 (P= 0.0021) and base deficit (P= 0.0454), but not hypothermia (P= 0.5289). Hypothermia remained a significant risk factor for MODS when systolic blood pressure, volume of fluid, and volume of blood infused were included in the multivariate model.
  
  
  CONCLUSIONS
  Hypothermia is common in severely injured trauma patients (nearly half of patients in this series) and is a significant risk factor for MODS but not mortality. The predictive value of base deficit for development of MODS is blunted in the presence of hypothermia. A low StO2 value predicts MODS and mortality in trauma patients and is a durable measure in both normothermic and hypothermic patient groups.
authors.affiliation: Division of Surgical Critical Care/Trauma, North Memorial Medical Center and Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA. beilm001@umn.edu
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Beilman
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Blondet
authors.forename: Teresa R
authors.initials: TR
authors.lastname: Nelson
authors.forename: Avery B
authors.initials: AB
authors.lastname: Nathens
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Moore
authors.forename: Peter
authors.initials: P
authors.lastname: Rhee
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Puyana
authors.forename: Ernest E
authors.initials: EE
authors.lastname: Moore
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Cohn
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007035:Hypothermia / Q000209:etiology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000401:mortality*; D011446:Prospective Studies; D012307:Risk Factors; D014193:Trauma Centers; D014481:United States; D014947:Wounds and Injuries / Q000150:complications / Q000401:mortality*