title: Hyperbaric oxygen therapy for consciousness disturbance following head injury in subacute phase.
abstract: BACKGROUND
  Hyperbaric oxygen (HBO) therapy has been shown to improve outcome after brain injury, however its mechanisms are not understood. The purpose of the present study was to investigate the effect of hyperbaric oxygen (HBO) therapy on the cerebral circulation and metabolism of patients with disturbances in consciousness after head injury in the subacute phase.
  
  
  METHODS
  Seven head injury patients underwent HBO treatment after leaving the intensive care unit. Oxygen (100% O2, 2.7 atm absolute) was delivered to patients in a hyperbaric chamber for 60 min every 24 h (total five treatments/patient). Cerebral circulation monitoring (mean flow velocity: mFV, and pulsatility index: PI at horizontal portion of middle cerebral artery by transcranial Doppler) and cerebral metabolism monitoring (arterio-jugular venous difference of oxygen: AJDO2 and jugular venous lactate: lac-JV) before and after the series of treatments were evaluated.
  
  
  RESULTS
  Both PI and lac-JV were significantly decreased after HBO theatment, while there were no significant changes in mFV and AJDO2. The decreased PI and lac-JV after HBO therapy might indicate that this treatment couples cerebral circulation and metabolism.
  
  
  CONCLUSIONS
  The measurement of cerebral circulation and metabolism parameters, especially PI and lac-JV, is useful for estimation of effect of HBO therapy in patients with distubances in consciousness after head injury in the subacute phase.
authors.affiliation: Department of Neurobiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0173, Japan. tanakamu@kms.ac.jp
authors.forename: Takehiro
authors.initials: T
authors.lastname: Nakamura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Susumu
authors.initials: S
authors.lastname: Yamashita
authors.forename: Kenya
authors.initials: K
authors.lastname: Kawakita
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kawai
authors.forename: Takashi
authors.initials: T
authors.lastname: Tamiya
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Itano
authors.forename: Seigo
authors.initials: S
authors.lastname: Nagao
mesh_terms: D000328:Adult; D000368:Aged; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D003244:Consciousness Disorders / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D006259:Craniocerebral Trauma / Q000150:complications* / Q000628:therapy; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D007601:Jugular Veins / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D008297:Male; D012044:Regression Analysis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D019344:Lactic Acid