High-resolution MR imaging of periarterial edema associated with biological inflammation in spontaneous carotid dissection.
It has been suggested that spontaneous cervical carotid artery dissection (sCAD) may result from arterial inflammation. Periarterial edema (PAE), occasionally described in the vicinity of the mural hematoma in patients with sCAD, may support this hypothesis. Using cervical high-resolution magnetic resonance imaging, three readers, blinded to the mechanism of carotid artery dissection, searched for PAE, defined as periarterial T2-hyperintensity and T1-hypointensity, in 29 consecutive CAD patients categorized as spontaneous CAD (sCAD, n = 18) or traumatic CAD (tCAD, n = 11; i.e., major head or neck trauma within 2 weeks before the clinical onset). The relationships between PAE, inflammatory biological markers, history of infection and CAD mechanism were explored. Multiple CADs (n = 8) were found only in sCAD patients. Compared with tCAD, patients with sCAD were more likely to have a recent history of infection (OR = 12.5 [(95%)CI = 1.3-119], p = 0.03), PAE (83% vs. 27%; OR = 13.3 [(95%)CI = 2.2-82.0], p = 0.005) and to have elevated CRP (OR = 6.1 [(95%)CI = 1.2-32.1], p = 0.0002) or ESR (OR = 8.8 [(95%)CI = 1.5-50.1], p = 0.002) values. Interobserver agreement was 0.84 or higher for PAE identification. sCAD was associated with PAE and biological inflammation. Our results support the hypothesis of an underlying arterial inflammation in sCAD.
Naggara
Olivier
O
Department of Neuroradiology, Paris-Descartes University, EA 4055, INSERM U894, Centre Hospitalier Sainte-Anne, 1 rue Cabanis, Paris 75014, France. o.naggara@ch-sainte-anne.fr
Touzé
Emmanuel
E
Marsico
Rodolpho
R
Leclerc
Xavier
X
Nguyen
Thanh
T
Mas
Jean-Louis
JL
Pruvo
Jean-Pierre
JP
Meder
Jean-François
JF
Oppenheim
Catherine
C
D001167:Arteritis / Q000150:complications* / Q000175:diagnosis*; D020215:Carotid Artery, Internal, Dissection / Q000150:complications* / Q000175:diagnosis*; D004487:Edema / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016037:Single-Blind Method