Functionalized carbon nanotubes specifically bind to alpha-chymotrypsin's catalytic site and regulate its enzymatic function.
Although carbon nanotubes (CNTs) have been shown to nonspecifically bind proteins through charge complementary, pi-pi stacking or hydrophobic interactions, they have not been shown to bind to a specific site on proteins. By generating surface molecular diversity, we created functionalized CNTs that recognize and bind to the catalytic site of alpha-chymotrypsin and inhibit its enzymatic activity competitively.
Zhang
Bin
B
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
Xing
Yuehan
Y
Li
Zhenwei
Z
Zhou
Hongyu
H
Mu
Qingxin
Q
Yan
Bing
B
D020134:Catalytic Domain; D002918:Chymotrypsin / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D016503:Drug Delivery Systems; D005453:Fluorescence; D057927:Hydrophobic and Hydrophilic Interactions; D037742:Nanotubes, Carbon / Q000737:chemistry*
D037742:Nanotubes, Carbon; D002918:Chymotrypsin; C117608:alpha-chymotrypsin