[Measurement of intra-oral pressure as a contributor for the understanding of pneumophonic coordination impairment in Parkinsonian dysarthria].
BACKGROUND
Parkinsonian dysarthria can alter oral communication of the patients in the long-term. Subthalamic nucleus (STN) stimulation represents an interesting therapeutic option, although it does not seem to improve axial signs, of which dysarthric speech. The objective of our study was to contribute to the evaluation of STN stimulation effects on speech impairment and in particular on pneumophonic coordination: this latter parameter can be assessed indirectly by evaluating the temporal progression of the intraoral pressure (IOP) during the expiratory phase; thus, IOP represents the transient expression of subglottal pressure (SGP).


METHODS
Using a dedicated system (EVA2), 20 parkinsonian patients were recorded in ON and OFF STN stimulation conditions in order to evaluate IOP on three measurement points (2nd, 4th and 6th consonants P) during realization of the sentence "Papa ne m'a pas parlé de beau-papa" ("Daddy did not speak to me about daddy-in-law") which corresponds to a breath group. Eleven control subjects were recorded in parallel in order to define reference measurements.


RESULTS
STN stimulation improved significantly IOP at the level of the initial measurement points (2nd P and 4th P), with an effect of convergence at the level of the third point (6th P) where the difference between OFF and ON STIM conditions was not significant any more. In addition, the performance of the patients ON STIM remained much lower than that of the control subjects.


CONCLUSIONS
Our results raise the significant concept that IOP measurement can be regarded as a relevant indicator for dysarthria in Parkinson's disease. They also show that the improvement of pneumophonic coordination by STN stimulation is restricted to the initial period of the expiratory phase, confirming again the mitigated and controversial effect of STN stimulation on axial signs.
Sarr
M M
MM
Laboratoire de physiologie médicale et d'explorations fonctionnelles, faculté de médecine, université Cheikh Anta Diop, Dakar, Sénégal. taphasarr@gmail.com
Pinto
S
S
Jankowski
L
L
Teston
B
B
Purson
A
A
Ghio
A
A
Régis
J
J
Peragut
J-C
JC
Viallet
F
F
D000161:Acoustic Stimulation; D017668:Age of Onset; D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods; D004401:Dysarthria / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D011312:Pressure; D013067:Speech Perception; D020531:Subthalamic Nucleus / Q000503:physiopathology*