title: Mucoepidermoid carcinoma of the trachea mimicking asthma.
abstract: In cases of recent asthma in which clinical control with the usual treatment (corticosteroids and bronchodilator) is unsatisfactory, it is important to consider other diagnoses, such as congestive heart failure, gastroesophageal reflux or other forms of airway obstruction. We report the case of a female patient with mucoepidermoid carcinoma of the trachea mimicking asthma. The patient presented cough and wheezing, as well as abnormal spirometry results with an obstructive pattern that was responsive to bronchodilators. One year later, the patient presented clinical and spirometric worsening. The chest X-ray revealed no abnormalities. A CT scan showed a vegetative lesion obstructing the tracheal lumen and located 1 cm from the carina. Fiberoptic bronchoscopy showed a finding similar to a bronchial carcinoid tumor. The anatomopathological diagnosis made after surgical resection was low-grade mucoepidermoid carcinoma, without lymph node involvement. Although the flow-volume curve was not suggestive of upper airway obstruction, the spirometry performed after the surgery showed a significant reduction in the degree of obstruction and greater reversibility after bronchodilator use. There was no evidence of recurrence of the disease or of the symptoms after a two-year follow-up period.
authors.affiliation: Universidade Estadual de Campinas, SP, Brasil. rkalaf@fcm.unicamp.br
authors.forename: Ricardo Kalaf
authors.initials: RK
authors.lastname: Mussi
authors.forename: Ivan Felizardo Contrera
authors.initials: IF
authors.lastname: Toro
authors.forename: Mônica Corso
authors.initials: MC
authors.lastname: Pereira
mesh_terms: D000368:Aged; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000627:therapeutic use; D018277:Carcinoma, Mucoepidermoid / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011859:Radiography; D014132:Trachea / Q000000981:diagnostic imaging; D014134:Tracheal Neoplasms / Q000175:diagnosis*; D017211:Treatment Failure
chemical_list: D001993:Bronchodilator Agents