Hybrid elastic and discrete-particle approach to biomembrane dynamics with application to the mobility of curved integral membrane proteins.
We introduce a simulation strategy to consistently couple continuum biomembrane dynamics to the motion of discrete biological macromolecules residing within or on the membrane. The methodology is used to study the diffusion of integral membrane proteins that impart a curvature on the bilayer surrounding them. Such proteins exhibit a substantial reduction in diffusion coefficient relative to "flat" proteins; this effect is explained by elementary hydrodynamic considerations.
Naji
Ali
A
Department of Chemistry and Biochemistry and Department of Physics, University of California, Santa Barbara, California 93106, USA.
Atzberger
Paul J
PJ
Brown
Frank L H
FL
D000465:Algorithms; D001703:Biophysics / Q000379:methods*; D003198:Computer Simulation; D004058:Diffusion; D008051:Lipid Bilayers / Q000378:metabolism; D046911:Macromolecular Substances; D008560:Membrane Fluidity; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D015233:Models, Statistical; D012984:Software
D008051:Lipid Bilayers; D046911:Macromolecular Substances; D008565:Membrane Proteins