[Bone fracture and the healing mechanisms. Molecular bases of fracture healing].
Fracture healing is a process comprising of a local bleeding followed by inflammation and differentiation of mesenchymal cells that lead to formation of soft extracellular matrix tissue, cartilage and bone. This pathway includes endo-chondral bone formation and in part intra-membranous bone formation. During this process several sets of cytokines are involved in the regulation of the progress in fracture healing. This paper reviews the molecules involved in fracture healing.
Noda
Masaki
M
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University.
Nagao
Masashi
M
Hanyu
Ryo
R
Miyai
Kentaro
K
Ezura
Yoichi
Y
D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D017102:Fracture Healing / Q000235:genetics* / Q000528:radiation effects*; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor; D020780:Matrix Metalloproteinase 9; D010012:Osteogenesis / Q000235:genetics / Q000502:physiology; D053495:Osteopontin; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D053245:RANK Ligand; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A
D019485:Bone Morphogenetic Proteins; D016207:Cytokines; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D053245:RANK Ligand; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D053495:Osteopontin; D016173:Macrophage Colony-Stimulating Factor; D020780:Matrix Metalloproteinase 9