title: Doxycycline sclerotherapy of an intraosseous femoral lymphatic malformation: case report and literature review.
abstract: Lymphatic malformations of the femur are rare benign conditions, with few published reports in the literature. Herein is presented an ambulatory 19-year-old male subject with a painful lymphatic malformation of the distal femur characterized by a serpiginous intraosseous and extraosseous extent. Laboratory and physical examination were unremarkable except for a right knee joint effusion and patellar grind. The malformation was sclerosed twice with doxycycline, resulting in patient-reported decreased associated pain from an intensity of 9 of 10 at presentation to 2 of 10 at 9-month follow-up.
authors.affiliation: Department of Interventional Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
authors.forename: Brandt C
authors.initials: BC
authors.lastname: Wible
authors.forename: Sally
authors.initials: S
authors.lastname: Mitchell
mesh_terms: D004318:Doxycycline / Q000008:administration & dosage*; D005269:Femur / Q000002:abnormalities* / Q000187:drug effects*; D006801:Humans; D008198:Lymph Nodes / Q000002:abnormalities* / Q000187:drug effects*; D044148:Lymphatic Abnormalities / Q000628:therapy*; D008297:Male; D015911:Sclerotherapy / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004318:Doxycycline