title: Serum amyloid a protein and C-reactive protein in normal pregnancy and preeclampsia.
abstract: OBJECTIVE
  To study plasma levels of serum amyloid A protein and C-reactive protein in pregnant women with and without preeclampsia and non-pregnant women. Plasma levels of haptoglobin, orosomucoid and ceruloplasmin were also analyzed.
  
  
  METHODS
  The study included 295 women with uncomplicated pregnancies, 57 women diagnosed with preeclampsia, and 58 healthy non-pregnant women. Plasma concentrations of acute phase proteins were analyzed by particle-enhanced immunoassays. Non-parametric Kruskal-Wallis and Mann-Whitney U tests were used to test differences between the groups.
  
  
  RESULTS
  Plasma levels of C-reactive protein and ceruloplasmin were increased in pregnant women with and without preeclampsia compared to non-pregnant women. Plasma levels of serum amyloid A protein and C-reactive protein were not elevated in women with preeclampsia compared to women with normal pregnancy.
  
  
  CONCLUSIONS
  The description of preeclampsia as a systemic inflammatory state was not reflected in the plasma levels of serum amyloid A protein and C-reactive protein.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Kristensen
authors.forename: D
authors.initials: D
authors.lastname: Wide-Swensson
authors.forename: V
authors.initials: V
authors.lastname: Lindstrom
authors.forename: C
authors.initials: C
authors.lastname: Schmidt
authors.forename: A
authors.initials: A
authors.lastname: Grubb
authors.forename: H
authors.initials: H
authors.lastname: Strevens
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007118:Immunoassay; D009961:Orosomucoid / Q000032:analysis; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D000685:Serum Amyloid A Protein / Q000032:analysis*
chemical_list: D006242:Haptoglobins; D009961:Orosomucoid; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein; D002570:Ceruloplasmin