title: Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane.
abstract: The plasma membrane is organized into various subdomains of clustered macromolecules. Such domains include adhesive structures (cellular synapses, substrate adhesions, and cell-cell junctions) and membrane invaginations (clathrin-coated pits and caveolae), as well as less well-defined domains such as lipid rafts and lectin-glycoprotein lattices. Domains are organized by specialized scaffold proteins including the intramembranous caveolins, which stabilize lipid raft domains, and the galectins, a family of animal lectins that cross-link glycoproteins forming molecular lattices. We review evidence that these heterogeneous microdomains interact to regulate substratum adhesion and cytokine receptor dynamics at the cell surface.
authors.affiliation: Deptartment of Cellular and Physiological Sciences, Life Sciences Institute University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Lajoie
authors.forename: Jacky G
authors.initials: JG
authors.lastname: Goetz
authors.forename: James W
authors.initials: JW
authors.lastname: Dennis
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Nabi
mesh_terms: D000818:Animals; D051242:Caveolin 1 / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D003034:Coated Pits, Cell-Membrane / Q000502:physiology; D021962:Membrane Microdomains / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D051242:Caveolin 1; D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface