[Preparation of nanostructured lipid carriers loaded with supercritical carbon dioxide fluid extraction of Xionggui powder].
OBJECTIVE
To study the preparation ofnanostructured lipid carriers loaded with supercritical carbon dioxide fluid extraction of Xionggui powder.


METHODS
Prepared nanostructured lipid carriers (NLC) loaded with supercritical carbon dioxide fluid extraction of Xionggui powder (XG-CO2-SFE) with a microemulsion ultrasonication method , established the best prescription of XG-CO2-SFE-NLC by orthogonal design methods with entrapment efficiency of nanoparticles as index, and investigated their physicochemical characterizations.


RESULTS
The best prescription was m(phospholipid) : m(S-40) : m(lipid carriers) = 5 : 2 : 1, the entrapment efficiency of nanopartices was 86.8%, results revealed that nanoparticles were sphere like with the mean size of 92.6 nm and the mean zeta potential was -20.68 mV.


CONCLUSIONS
The prep aration method of the XG-CO2-SFE-NLC is appropriate.
Chen
Yanjun
Y
Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China.
Chen
Feng
F
Wei
Wei
W
Zhang
Xiaojun
X
Feng
Qingran
Q
Jin
Rixian
R
D002245:Carbon Dioxide / Q000737:chemistry*; D025924:Chromatography, Supercritical Fluid; D004337:Drug Carriers / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification*; D004655:Emulsions; D016014:Linear Models; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D011208:Powders
D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D008055:Lipids; D011208:Powders; C540808:xionggui; D002245:Carbon Dioxide