title: Tissue microarrays as a tool in the discovery and validation of tumor markers.
abstract: Tissue microarrays are a platform of condensed histopathology that has revolutionized the translation of basic science to clinical utility. Tissue microarrays have resulted in a paradigm shift from histopathology to immunopathology and moved analysis of small selected samples sets of tens of specimens to a high-throughput environment of hundreds of specimens. Tissue microarrays have influenced validation strategies, but have a role in discovery as well, allowing a pathways approach to analysis of tumors.
authors.affiliation: Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. genejock@helix.nih.gov
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Hewitt
mesh_terms: D001681:Biological Assay; D014408:Biomarkers, Tumor / Q000032:analysis*; D003299:Cooperative Behavior; D006801:Humans; D015203:Reproducibility of Results; D046888:Tissue Array Analysis / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor