title: Chiral amino amides for the ruthenium(II)-catalyzed asymmetric transfer hydrogenation reaction of ketones in water.
abstract: The chiral amino amide 3 was derived from L-proline and used for the [RuCl2(p-cymene)]2-catalyzed asymmetric transfer hydrogenation of prochiral ketones performed in water. Moderate to good chemical selectivities (up to 95% yield) and enantioselectivities (up to 90% ee) were obtained in the presence of 2 mol % of TBAB (n-Bu4NBr) as the phase transfer catalyst.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Suzhou University, Suzhou, People's Republic of China. jcmao@suda.edu.cn
authors.forename: Jincheng
authors.initials: J
authors.lastname: Mao
authors.forename: Jun
authors.initials: J
authors.lastname: Guo