Haploidentical hematopoietic stem cell transplantation in child hematologic malignancies with G-CSF-mobilized marrow grafts without T-cell depletion: a single-center report of 45 cases.
In this report, the authors describe a protocol for haploidentical bone marrow transplantation in children who received G-CSF-mobilized bone marrow grafts without T-cell depletion from HLA-mismatched parents. Forty-two of 45 patients achieved complete donor hematopoietic engraftment; the medium time for neutrophil and platelet recovery was 17 and 19 days, respectively. Three died of early transplantation-associated complications; other causes of death included relapse (11 cases), fungal pneumonia (5), and acute graft-versus-host disease (2). The total disease-free survival rate longer than 2 years was 53.3%. These data suggest that haploidentical hematopoietic transplantation is an alterative strategy for children who lack immediate access to HLA-matched sources.
Wang
Heng-Xiang
HX
Department of Hematology, The General Hospital of the Air Force, PLA, Beijing, China.
Yan
Hong-Min
HM
Duan
Lian-Ning
LN
Wang
Zhi-Dong
ZD
Zhu
Ling
L
Xue
Mei
M
Liu
Jing
J
Hu
Liang-Ding
LD
Guo
Zi-Kuan
ZK
D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000379:methods; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006680:HLA Antigens; D006239:Haplotypes; D019337:Hematologic Neoplasms / Q000150:complications / Q000401:mortality / Q000601:surgery*; D006410:Hematopoiesis; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D006648:Histocompatibility / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D014184:Transplantation, Homologous
D006680:HLA Antigens; D016179:Granulocyte Colony-Stimulating Factor