title: Comparison of human and porcine skin for characterization of sunscreens.
abstract: The universal sun protection factor (USPF) characterizing sunscreen efficacy based on spectroscopically determined data, which were obtained using the tape stripping procedure. The USPF takes into account the complete ultraviolet (UV) spectral range in contrast to the classical sun protection factor (SPF). Until now, the USPF determination has been evaluated only in human skin. However, investigating new filters not yet licensed excludes in vivo investigation on human skin but requires the utilization of a suitable skin model. The penetration behavior and the protection efficacy of 10 commercial sunscreens characterized by USPF were investigated, comparing human and porcine skin. The penetration behavior found for typical UV filter substances is nearly identical for both skin types. The comparison of the USPF obtained for human and porcine skin results in a linear relation between both USPF values with a correlation factor R(2)=0.98. The results demonstrate the possibility for the use of porcine skin to determine the protection efficacy of sunscreens.
authors.affiliation: Charite-Universitatsmedizin Berlin, Department of Dermatology, Center of Experimental and Applied Cutaneous Physiology, Chariteplatz 1, 10117 Berlin, Germany.
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Weigmann
authors.forename: Sabine
authors.initials: S
authors.lastname: Schanzer
authors.forename: Alexa
authors.initials: A
authors.lastname: Patzelt
authors.forename: Virginie
authors.initials: V
authors.lastname: Bahaban
authors.forename: Fabienne
authors.initials: F
authors.lastname: Durat
authors.forename: Wolfram
authors.initials: W
authors.lastname: Sterry
authors.forename: Jürgen
authors.initials: J
authors.lastname: Lademann
mesh_terms: D000328:Adult; D000818:Animals; D006801:Humans; D008875:Middle Aged; D012879:Skin Physiological Phenomena / Q000187:drug effects* / Q000528:radiation effects*; D013045:Species Specificity; D013473:Sunscreening Agents / Q000008:administration & dosage*; D013552:Swine; D014466:Ultraviolet Rays; D055815:Young Adult
chemical_list: D013473:Sunscreening Agents