[Studies on self-microemulsifying drug preparations of total flavones of Hippophae rhamnoides].
OBJECTIVE
To develop self-microemulsifying preparations of total flavones of Hippophae Rhamnoides L. (TFH) and the determination method of dissolution.


METHODS
The equilibrium solubility of TFH in different compositions of oils, emulsifier and assistant emulsifier was investigated. The self-microemulsion formula was optimized by constructing the pseudo-ternary phase diagrams of blank SMEDDS determining the self-microemulsifying efficiency and the stability of the SMEDDS. The 2 hours dissolution curve of TFH self-microemulsifying preparations was established. The optimal self-microemulsion formula was composed of MIGLYOL 812 N, Cremophor EL and 1,2-Propylene glycol.


RESULTS
The ratio of them was 0.5:5.7:3.8. The average particle size was 12.1 nm. The dissolution rate at 10 minutes of TFH self-microemulsifying preparation was 131% higher than that of Xinda kang tablets.


CONCLUSIONS
The acquired microemulsion with small particle size is stable. The dissolution rate is evidently improved compared with market dosage forms.
Xie
Yan
Y
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. rosexie_2004@163.com
Rong
Rong
R
Li
Guowen
G
Yuan
Xiurong
X
Wang
Jianying
J
D002138:Calibration; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D004655:Emulsions; D047309:Flavones / Q000737:chemistry*; D031281:Hippophae / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013607:Tablets
D004365:Drugs, Chinese Herbal; D004655:Emulsions; D047309:Flavones; D012997:Solvents; D013607:Tablets