Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells.
The goal of the current study was to investigate the expression of transient receptor potential vanilloid-1 (TRPV1) on human in vitro differentiated monocyte-derived dendritic cells (DCs) and to dissect the corresponding role of TRPV1-signaling in DC-specific functions. TRPV1 expression was identified both at the protein and gene levels in human DCs. Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion. These data introduce TRPV1-coupled signaling as a novel player in human monocyte-derived DC biology with anti-inflammatory actions.
Tóth
Balázs I
BI
Department of Physiology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, 4032 Debrecen, Nagyerdei krt. 98, P.O. Box 22, Hungary.
Benko
Szilvia
S
Szöllosi
Attila G
AG
Kovács
László
L
Rajnavölgyi
Eva
E
Bíró
Tamás
T
D002454:Cell Differentiation; D003713:Dendritic Cells / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D050916:TRPV Cation Channels / Q000378:metabolism*
D050916:TRPV Cation Channels; C494482:TRPV1 protein, human