Disposition of TF-PEG-Liposome-BSH in tumor-bearing mice.
BNCT requires high concentration and selective delivery of (10)B to the tumor cell. To improve the drug delivery in BNCT, we conducted a study by devising TPLB. We administrated three types of boron delivery systems: BSH, PLB and TPLB, to Oral SCC bearing mice. Results confirmed that (10)B concentration is higher in the TPLB group than in the BSH group and that TPLB is significantly effective as boron delivery system.
Ito
Y
Y
Department of Dentistry and Oral Surgery, Division of Medicine for Function and Morphology of Sensory Organs, Osaka Medical College, Japan. ora059@poh.osaka-med.ac.jp
Kimura
Y
Y
Shimahara
T
T
Ariyoshi
Y
Y
Shimahara
M
M
Miyatake
S
S
Kawabata
S
S
Kasaoka
S
S
Ono
K
K
D000818:Animals; D001894:Borohydrides / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000532:radiotherapy*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D008081:Liposomes; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D011092:Polyethylene Glycols; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013438:Sulfhydryl Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014168:Transferrin
D001894:Borohydrides; D008081:Liposomes; D011838:Radiation-Sensitizing Agents; D013438:Sulfhydryl Compounds; D014168:Transferrin; C014651:mercaptoundecahydrododecaborate; D011092:Polyethylene Glycols