title: Modeling cognitive endophenotypes of schizophrenia in mice.
abstract: Schizophrenia is a complex mental disorder that is still characterized by its symptoms rather than by biological markers because we have only a limited knowledge of its underlying molecular basis. In the past two decades, however, technical advances in genetics and brain imaging have provided new insights into the biology of the disease. Based on these advances we are now in a position to develop animal models that can be used to test specific hypotheses of the disease and explore mechanisms of pathogenesis. Here, we consider some of the insights that have emerged from studying in mice the relationship between defined genetic and molecular alterations and the cognitive endophenotypes of schizophrenia.
authors.affiliation: Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA. ck491@columbia.edu
authors.forename: Christoph
authors.initials: C
authors.lastname: Kellendonk
authors.forename: Eleanor H
authors.initials: EH
authors.lastname: Simpson
authors.forename: Eric R
authors.initials: ER
authors.lastname: Kandel
mesh_terms: D000818:Animals; D003071:Cognition / Q000502:physiology*; D003342:Corpus Striatum / Q000503:physiopathology; D004195:Disease Models, Animal; D018628:Gene Dosage; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008957:Models, Genetic; D010641:Phenotype; D011110:Polymorphism, Genetic; D017397:Prefrontal Cortex / Q000503:physiopathology; D017448:Receptors, Dopamine D2 / Q000502:physiology; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism; D012565:Schizophrenic Psychology
chemical_list: D017448:Receptors, Dopamine D2