Papillary glioneuronal tumor-evidence of stem cell origin with biphenotypic differentiation.
Papillary glioneuronal tumors are newly recognized seizure producing tumors. We report two such cases with immunohistochemical characterization of glial and neuronal components and briefly review literature. Co-localization of glial and neuronal markers was demonstrable on confocal microscopy with expression of stem cell markers (Nestin and CD133) suggesting possible origin from neuroepithelial stem cell with biphenotypic differentiation.
Govindan
Aparna
A
Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
Mahadevan
A
A
Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India. amahadevan@nimhans.kar.nic.in.
Bhat
D I
DI
Department of Neurosurgery, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
Arivazhagan
A
A
Department of Neurosurgery, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
Chakraborti
Shrijeet
S
Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
Suja
M S
MS
Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
Phalguni
A A
AA
Department of Neurophysiology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
Sampath
S
S
Department of Neurosurgery, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
Chandramouli
B A
BA
Department of Neurosurgery, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
Shankar
S K
SK
Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, 560 029, India.
D000071916:AC133 Antigen; D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D001932:Brain Neoplasms / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000473:pathology*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008297:Male; D008579:Meningioma; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009457:Neuroglia / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D010455:Peptides / Q000378:metabolism
D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; D009419:Nerve Tissue Proteins; C000606023:PROM1 protein, human; D010455:Peptides