Laboratory identification of lupus anticoagulants.
Lupus anticoagulants (LA) are acquired autoantibodies that can cause antiphospholipid syndrome. LAs prolong phospholipid-dependent coagulation tests, acting as nonspecific inhibitors that are neutralized in the presence of excess phospholipid. However, there is no gold standard test and the testing is influenced by a number of variables. This article summarizes laboratory testing for LAs, with particular focus on technical issues and limitations of testing. Am. J. Hematol. 2009. (c) 2009 Wiley-Liss, Inc.
Smock
Kristi J
KJ
ARUP Laboratories, Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. kristi.smock@aruplab.com
Rodgers
George M
GM
D001780:Blood Coagulation Tests / Q000379:methods; D019411:Clinical Laboratory Techniques / Q000379:methods*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood*
D016682:Lupus Coagulation Inhibitor