title: Primary patency of Wallstents in malignant bile duct obstruction: single vs. two or more noncoaxial stents.
abstract: The purpose of this study was to determine the primary patency of two or more noncoaxial self-expanding metallic Wallstents (Boston Scientific, Natick, MA) and to compare this with the primary patency of a single stent in malignant bile duct obstruction. From August 2002 to August 2004, 127 patients had stents placed for malignant bile duct obstruction. Forty-five patients were treated with more than one noncoaxial self-expanding metallic stents and 82 patients had a single stent placed. Two patients in the multiple-stent group were lost to follow-up. The primary patency period was calculated from the date of stenting until the first poststenting intervention for stent occlusion, death, or the time of last documented follow-up. The patency of a single stent was significantly different from that of multiple stents (P = 0.0004). In the subset of patients with high bile duct obstruction, the patency of a single stent remained significantly different from that of multiple stents (P = 0.02). In the single-stent group, there was no difference in patency between patients with high vs. those with low bile duct obstruction (P = 0.43). The overall median patency for the multistent group and the single-stent group was 201 and 261 days, respectively. In conclusion, the patency of a single stent placed for malignant low or high bile duct obstruction is similar, and significantly longer than, that of multiple stents placed for malignant high bile duct obstruction. Given the median patency of 201 days, when indicated, percutaneous stenting of multiple bile ducts is an effective palliative measure for patients with malignant high bile duct obstruction.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, Interventional Radiology Section, 1275 York Avenue, H118A, New York, NY 10065, USA. maybodym@mskcc.org
authors.forename: Majid
authors.initials: M
authors.lastname: Maybody
authors.forename: Karen T
authors.initials: KT
authors.lastname: Brown
authors.forename: Lynn A
authors.initials: LA
authors.lastname: Brody
authors.forename: Anne M
authors.initials: AM
authors.lastname: Covey
authors.forename: Constantinos T
authors.initials: CT
authors.lastname: Sofocleous
authors.forename: Raymond H
authors.initials: RH
authors.lastname: Thornton
authors.forename: George I
authors.initials: GI
authors.lastname: Getrajdman
mesh_terms: D000368:Aged; D002758:Cholangiography; D002779:Cholestasis / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D003287:Contrast Media; D004067:Digestive System Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D015607:Stents; D016896:Treatment Outcome; D014654:Vascular Patency
chemical_list: D003287:Contrast Media