[Genetic polymorphisms of oxidation and acetylation in cancers of digestive system].
Cancer diseases are the second most common cause of mortality in Poland. The cancers of digestive system: colorectal cancer, gastric cancer, pancreatic cancer and liver cancer are the first common malignant tumour. Pathogenesis of cancer diseases is connected with influence of environmental factors with individual dependent among others on detoxification enzymes. Genetic differences in the regulation, expression and activity of genes coding for phase I and phase II drug-metabolizing enzymes can be crucial factors in defining cancer of digestive system susceptibility. In this review our current knowledge about polymorphism in several of these genes is summarized.
Barańska
Małgorzata
M
Medical University of Lódź, Department of Pharmacogenetics, Poland. mbaranska@pharm.am.lodz.pl
Skretkowicz
Jadwiga
J
D000107:Acetylation; D004067:Digestive System Neoplasms / Q000201:enzymology* / Q000235:genetics*; D006801:Humans; D010084:Oxidation-Reduction; D011110:Polymorphism, Genetic; D015262:Xenobiotics / Q000378:metabolism
D015262:Xenobiotics