Synthesis of macrocyclic beta-strand templates by ring closing metathesis.
We report the synthesis of macrocycles 1-6 via ring closing metathesis of dienes 7-12. Addition of chlorodicyclohexylborane to thermal and microwave assisted RCM of dienes 8 and 9 markedly improves the yield. The geometric isomers of macrocycles 1-3 and 5 have been assigned using X-ray crystallography and NMR.
Abell
Andrew D
AD
Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. andrew.abell@adelaide.edu.au
Alexander
Nathan A
NA
Aitken
Steven G
SG
Chen
Hongyuan
H
Coxon
James M
JM
Jones
Matthew A
MA
McNabb
Stephen B
SB
Muscroft-Taylor
Andrew
A