Growth factors and glucose homeostasis in diabetic rats: effects of exercise training.
To investigate the alterations of glucose homeostasis and variables of the insulin-like growth factor-1 (IGF-1) growth system in sedentary and trained diabetic (TD) rats, Wistar rats were divided into sedentary control (SC), trained control (TC), sedentary diabetic (SD), and TD groups. Diabetes was induced by Alloxan (35 mg kg(-1) b.w.). Training program consisted of swimming 5 days week(-1), 1 h day(-1), during 8 weeks. Rats were sacrificed and blood was collected for determinations of serum glucose, insulin, growth hormone (GH), IGF-1, and IGF binding protein-3 (IGFBP-3). Muscle and liver were removed to evaluate glycogen content. Cerebellum was extracted to determinate IGF-1 content. Diabetes decreased serum GH, IGF-1, IGFBP-3, liver glycogen, and cerebellum IGF-1 peptide content in baseline condition. Physical training recovered liver glycogen and increased serum and cerebellum IGF-1 peptide in diabetic rats. Physical training induces important metabolic and hormonal alterations that are associated with an improvement in glucose homeostasis and serum and cerebellum IGF-1 concentrations.
Gomes
Ricardo José
RJ
Department of Physical Education, São Paulo State University (UNESP), Rio Claro-SP, Brazil. ricardojosegome@gmail.com
Leme
José Alexandre Curiacos de Almeida
JA
de Moura
Leandro Pereira
LP
de Araújo
Michel Barbosa
MB
Rogatto
Gustavo Puggina
GP
de Moura
Rodrigo Ferreira
RF
Luciano
Eliete
E
de Mello
Maria Alice Rostom
MA
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002531:Cerebellum / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000628:therapy; D013006:Growth Hormone / Q000032:analysis; D007328:Insulin / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
D001786:Blood Glucose; D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D008112:Liver Glycogen; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone