[Methylene blue as a supressor of the genotoxic effect of ultraviolet radiation with a wavelength of 300-400 nm].
Ultraviolet radiation with a wavelength of 300-400 nm is characteristic of sunlight at the earth surface and causes DNA damage mediated by energy transfer to O2 with the transformation of the latter in the singlet state. In connection with this, scavengers of reactive oxygen species (ROSs) are potential protectors against the genotoxic effect of this kind of radiation. It was found that the methylene blue dye at doses differing by several orders of magnitude from those that are toxic for humans is able to suppress completely the SOS response induced by UV with a wavelength of 300--400 nm in Escherichia coli.
Chistiakov
V A
VA
Sazykina
M A
MA
Kolenko
M A
MA
Cherviakov
G G
GG
Usatov
A V
AV
D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008751:Methylene Blue / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013014:SOS Response, Genetics / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*
D004791:Enzyme Inhibitors; D017382:Reactive Oxygen Species; D010100:Oxygen; D008751:Methylene Blue