title: [Clinical and experimental considerations for evaluation of Eustachian tube physiology].
abstract: BACKGROUND
  Eustachian tube dysfunction plays a pivotal role in the pathogenesis of otitis media with effusion. Besides the lack of sufficient animal models to investigate the role of gastroesophageal reflux on Eustachian tube function, there is no reliable test that clinically allows the quantification of Eustachian tube function. Therefore, we established a Mongolian gerbil model to trace gastroesophageal reflux into the middle ear. In gerbils with traceable reflux, the refluxate reached the both middle ears through the Eustachian tubes in most cases.
  
  
  METHODS
  Clinical studies were performed to analyze the reproducibility of measuring the accuracy of modified tube manometry in healthy Caucasians.
  
  
  RESULTS
  Tube manometry was found to be a reliable and reproducible tool for measuring Eustachian tube function.
  
  
  CONCLUSIONS
  Both our animal model and the clinical application of tube manometry are likely to be useful for further experimental and clinical studies.
authors.affiliation: Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Klinikum Bielefeld, Teutoburger Strasse 50, 33604, Bielefeld, Deutschland. Holger.Sudhoff@sk-bielefeld.de
authors.forename: H
authors.initials: H
authors.lastname: Sudhoff
authors.forename: T
authors.initials: T
authors.lastname: Ockermann
authors.forename: R
authors.initials: R
authors.lastname: Mikolajczyk
authors.forename: J
authors.initials: J
authors.lastname: Ebmeyer
authors.forename: D
authors.initials: D
authors.lastname: Korbmacher
authors.forename: D
authors.initials: D
authors.lastname: Garten
authors.forename: S
authors.initials: S
authors.lastname: Schreiber
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005064:Eustachian Tube / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000503:physiopathology*; D005849:Gerbillinae; D006801:Humans; D008365:Manometry / Q000379:methods*; D010034:Otitis Media with Effusion / Q000209:etiology* / Q000503:physiopathology*