title: Postprandial hyperglycemia as an etiological factor in vascular failure.
abstract: Postprandial hyperglycemia is characterized by hyperglycemic spikes that induce endothelial dysfunction, inflammatory reactions and oxidative stress, which may lead to progression of atherosclerosis and occurrence of cardiovascular events. Emerging data indicate that postprandial hyperglycemia or even impaired glucose tolerance may predispose to progression of atherosclerosis and cardiovascular events. There is evidence that postprandial hyperglycemia, but not fasting hyperglycemia, independently predicts the occurrence of cardiovascular events. We proposed a concept of 'vascular failure' as a comprehensive syndrome of vascular dysfunction extending from risk factors to advanced atherosclerotic disease. Postprandial hyperglycemia is therefore one of the very important pathophysiological states contributing to vascular failure. Accordingly, controlling postprandial hyperglycemia should be the focus of future clinical investigation as a potential target for preventing vascular failure.
authors.affiliation: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan. inouete@med.saga-u.ac.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Node
authors.forename: Teruo
authors.initials: T
authors.lastname: Inoue
mesh_terms: D050197:Atherosclerosis / Q000209:etiology; D002318:Cardiovascular Diseases / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000209:etiology / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D018149:Glucose Intolerance / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007249:Inflammation / Q000503:physiopathology; D018384:Oxidative Stress; D012307:Risk Factors; D014652:Vascular Diseases / Q000209:etiology* / Q000517:prevention & control
chemical_list: D007004:Hypoglycemic Agents