Ruthenium-catalyzed selective monoamination of vicinal diols.
The monoamination of vicinal diols in the presence of in situ generated ruthenium catalysts has been investigated. Among the various phosphines tested in combination with [Ru(3)(CO)(12)], N-phenyl-2-(dicyclohexyl-phosphanyl)pyrrole showed the best performance. After optimization of the reaction conditions this system was applied to different secondary amines and anilines as well as a number of vicinal diols. With the exception of ethylene glycol, monoamination of the vicinal diols occurred selectively and the corresponding amino alcohols were obtained in good yields, producing water as the only side product.
Bähn
Sebastian
S
Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Germany.
Tillack
Annegret
A
Imm
Sebastian
S
Mevius
Kathleen
K
Michalik
Dirk
D
Hollmann
Dirk
D
Neubert
Lorenz
L
Beller
Matthias
M
D000438:Alcohols / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000737:chemistry*; D000605:Amino Alcohols / Q000138:chemical synthesis*; D002384:Catalysis; D055772:Green Chemistry Technology / Q000379:methods; D012428:Ruthenium
D000438:Alcohols; D000588:Amines; D000605:Amino Alcohols; D012428:Ruthenium