title: Topiramate and asymptomatic ocular angle narrowing: a prospective pilot study.
abstract: OBJECTIVE
  To investigate whether subclinical ciliochoroidal effusion and resulting asymptomatic angle narrowing occurs in patients taking topiramate, by ultrasound biomicroscopy (UBM).
  
  
  METHODS
  Chinese patients aged 18-75 years for whom topiramate was indicated were recruited. Examinations including UBM were performed before and 4 weeks after commencement of topiramate.
  
  
  RESULTS
  In this pilot of 20 eyes of 20 patients, there were no statistically significant changes in the angle parameters noted on gonioscopy or UBM, including anterior chamber depth, angle-opening distance at 500 mum, trabecular ciliary process distance, trabecular-iris angle, and scleral thickness.
  
  
  CONCLUSIONS
  Short-term use of topiramate does not induce asymptomatic angle narrowing.
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong. dexleung@alumni.cuhk.net
authors.forename: D Y L
authors.initials: DY
authors.lastname: Leung
authors.forename: H
authors.initials: H
authors.lastname: Leung
authors.forename: N
authors.initials: N
authors.lastname: Baig
authors.forename: P
authors.initials: P
authors.lastname: Kwan
authors.forename: Y Y Y
authors.initials: YY
authors.lastname: Kwong
authors.forename: K S
authors.initials: KS
authors.lastname: Wong
authors.forename: D S C
authors.initials: DS
authors.lastname: Lam
mesh_terms: D000328:Adult; D000869:Anterior Eye Segment / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D044466:Asian People; D002681:China; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000009:adverse effects*; D010865:Pilot Projects; D011446:Prospective Studies; D000077236:Topiramate; D014792:Visual Acuity / Q000187:drug effects; D055815:Young Adult
chemical_list: D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose