title: Characterization of peri-infarct zone heterogeneity by contrast-enhanced multidetector computed tomography: a comparison with magnetic resonance imaging.
abstract: OBJECTIVE
  This study examined whether multidetector computed tomography (MDCT) improves the ability to define peri-infarct zone (PIZ) heterogeneity relative to magnetic resonance imaging (MRI).
  
  
  BACKGROUND
  The PIZ as characterized by delayed contrast-enhancement (DE)-MRI identifies patients susceptible to ventricular arrhythmias and predicts outcome after myocardial infarction (MI).
  
  
  METHODS
  Fifteen mini-pigs underwent coronary artery occlusion followed by reperfusion. Both MDCT and MRI were performed on the same day approximately 6 months after MI induction, followed by animal euthanization and ex vivo MRI (n = 5). Signal density threshold algorithms were applied to MRI and MDCT datasets reconstructed at various slice thicknesses (1 to 8 mm) to define the PIZ and to quantify partial volume effects.
  
  
  RESULTS
  The DE-MDCT reconstructed at 8-mm slice thickness showed excellent correlation of infarct size with post-mortem pathology (r2 = 0.97; p < 0.0001) and MRI (r2 = 0.92; p < 0.0001). The DE-MDCT and -MRI were able to detect a PIZ in all animals, which correlates to a mixture of viable and nonviable myocytes at the PIZ by histology. The ex vivo DE-MRI PIZ volume decreased with slice thickness from 0.9 +/- 0.2 ml at 8 mm to 0.2 +/- 0.1 ml at 1 mm (p = 0.01). The PIZ volume/mass by DE-MDCT increased with decreasing slice thickness because of declining partial volume averaging in the PIZ, but was susceptible to increased image noise.
  
  
  CONCLUSIONS
  A DE-MDCT provides a more detailed assessment of the PIZ in chronic MI and is less susceptible to partial volume effects than MRI. This increased resolution best reflects the extent of tissue mixture by histopathology and has the potential to further enhance the ability to define the substrate of malignant arrhythmia in ischemic heart disease noninvasively.
authors.affiliation: Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21205, USA.
authors.forename: Karl H
authors.initials: KH
authors.lastname: Schuleri
authors.forename: Marco
authors.initials: M
authors.lastname: Centola
authors.forename: Richard T
authors.initials: RT
authors.lastname: George
authors.forename: Luciano C
authors.initials: LC
authors.lastname: Amado
authors.forename: Kristine S
authors.initials: KS
authors.lastname: Evers
authors.forename: Kakuya
authors.initials: K
authors.lastname: Kitagawa
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Vavere
authors.forename: Robert
authors.initials: R
authors.lastname: Evers
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Hare
authors.forename: Christopher
authors.initials: C
authors.lastname: Cox
authors.forename: Elliot R
authors.initials: ER
authors.lastname: McVeigh
authors.forename: João A C
authors.initials: JA
authors.lastname: Lima
authors.forename: Albert C
authors.initials: AC
authors.lastname: Lardo
mesh_terms: D000818:Animals; D003287:Contrast Media; D005260:Female; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D013552:Swine; D013556:Swine, Miniature; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media