Three new alkaloids from Galanthus nivalis and Galanthus elwesii.
Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3'-O-(3',3''-dihydroxybutanoyl)hamayne and 11,3'-O-(3',3''-dihydroxybutanoyl)hamayne from G. nivalis and 2-O-(3'-hydroxybutanoyl)lycorine from G. elwesii. Additionally, 3,11-O-(3',3''-dihydroxybutanoyl)hamayne, 3,11,3'-O-(3',3'',3'''-trihydroxybutanoyl)hamayne, 8-O-demethylvasconine, tazettine, epimacronine, and ismine from G. nivalis; 2-O-(3'-acetoxybutanoyl)lycorine and incartine from G. elwesii; and hamayne, 11-O-(3'-hydroxybutanoyl)hamayne and lycorine from both species were isolated. Their structures were determined by EI-MS, HR-MS, CD, and 1D and 2D NMR (COSY, NOESY, HMQC, and HMBC) experiments.
Berkov
Strahil
S
Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain.
Cuadrado
María
M
Osorio
Edison
E
Viladomat
Francesc
F
Codina
Carles
C
Bastida
Jaume
J
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D005591:Chemical Fractionation; D027801:Galanthus / Q000737:chemistry*; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular
C547040:11,3'-O-(3',3'-dihydroxybutanoyl)hamayne; C547039:2-O-(3'-hydroxybutanoyl)lycorine; C547038:3,3'-O-(3',3'-dihydroxybutanoyl)hamayne; D000470:Alkaloids