The preventive effect of adjuvant-free administration of TNF-PADRE autovaccine on collagen-II-induced rheumatoid arthritis in mice.
Adjuvants are necessary to elicit high titers of antibodies in vaccine-immunization procedures. We previously developed a mouse tumor necrosis factor-alpha (TNF-alpha) autovaccine (mTNF-PADRE) capable of inducing anti-TNF-alpha antibodies. In this study, we investigated the therapeutic effect of adjuvant-free administration of the autovaccine on collagen-type-II-induced rheumatoid arthritis (CIA) in mice. Our results showed that the vaccine could ameliorate the symptoms of CIA in mice. In addition, this study suggests that it is possible to control the antibody levels in mice immunized with mTNF-PADRE without adjuvant.
Wan
Yi
Y
State Key Laboratory of Cancer Biology, Xi'an, People's Republic of China.
Yuan
Shifang
S
Xue
Xiaochang
X
Li
Meng
M
Qin
Xin
X
Zhang
Cun
C
Wang
Weihua
W
Jiang
Changli
C
Wu
Shouzhen
S
Liu
Yan
Y
Zhu
Wenhua
W
Ran
Yonggang
Y
Zhang
Zhen
Z
Han
Wei
W
Zhang
Yingqi
Y
D000276:Adjuvants, Immunologic; D000818:Animals; D000843:Ankle Joint / Q000276:immunology / Q000473:pathology; D000917:Antibody Formation / Q000276:immunology; D001169:Arthritis, Experimental / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D054991:Autovaccines / Q000008:administration & dosage* / Q000276:immunology; D024043:Collagen Type II / Q000276:immunology; D004195:Disease Models, Animal; D007719:Knee Joint / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism
D000276:Adjuvants, Immunologic; D054991:Autovaccines; D024043:Collagen Type II; D014409:Tumor Necrosis Factor-alpha; C523999:mTNF-PADRE