title: Simple use of the suppository type povidone-iodine can prevent infectious complications in transrectal ultrasound-guided prostate biopsy.
abstract: Purpose. To determine the effect of simple use of suppository povidone-iodine on infectious complications after transrectal ultrasonography-guided biopsy of the prostate. Methods. All 481 patients are included and received antibiotic prophylaxis. Among them, 360 patients received povidone-iodine suppository (Gynobetadine; 200 mg) immediately prior to biopsy and 121 patients did not. Infectious complications were classified. To evaluate bactericidal effects, we counted bacterial colonies in the rectum, harvested from a rectal swab before insertion of the suppository and after biopsy. Aliquots of the suspended bacterial strains were added to Mueller-Hinton agar medium for incubation. Colony counts were determined. Results. Infectious complications developed in 1 case (0.3%) in the rectal preparation group (Group 1) and in 8 cases (6.6%) in the nonrectal preparation group (Group 2). One in Group 1 had a fever without sepsis. Two patients had sepsis and six had fever without sepsis in Group 2. Rectal preparation was a statistically significant risk factor influencing the development of infectious complications. In vitro experiments, the mean number of colony-forming units decreased 99.9% after the rectal povidone-iodine preparation. Conclusions. All through the biopsy, povidone-iodine melted into the rectum and decreased the bacterial colony count. Simple use of povidone-iodine suppository before prostate biopsy minimizes the risk of infectious complications.
authors.affiliation: Department of Urology, College of Medicine, Pochon CHA University, Sungnam 463-712, South Korea. dsparkmd@cha.ac.kr
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Park
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Oh
authors.forename: Jin Ha
authors.initials: JH
authors.lastname: Lee
authors.forename: Woong Ki
authors.initials: WK
authors.lastname: Jang
authors.forename: Young Kwon
authors.initials: YK
authors.lastname: Hong
authors.forename: Sung Keun
authors.initials: SK
authors.lastname: Hong