Total synthesis of siphonazoles by the use of a conjunctive oxazole building block.
The preparation of 4-carbethoxy-5-methyl-2-(phenylsulfonyl)methyloxazole and its use in the elaboration of more complex oxazoles are described. A total synthesis of the unique natural products, siphonazoles A and B, illustrates an application of the new building block.
Zhang
Jianmin
J
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver BC V6T 1Z1, Canada.
Ciufolini
Marco A
MA
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects; D002384:Catalysis; D004926:Escherichia coli; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
D001688:Biological Products; D010080:Oxazoles; C520719:siphonazole