Dietary diacylglycerol oil has no effect on hypertriacylglycerolaemia in lipoprotein lipase-deficient cats.
A commercially available vegetable oil containing a high concentration (87 %, w/w) of diacylglycerol (DAG) has been investigated in humans and animals for potential beneficial effects in reducing serum TAG concentrations in fasting and postprandial states. Effects of DAG oil as a sole dietary fat source (25 % metabolisable energy) were evaluated in a feline model of hypertriacylglycerolaemia. Eleven adult (1.5 (sem 0.1) years) male cats deficient of lipoprotein lipase (LPL) catalytic activity from a heritable point mutation of the LPL gene were acclimatised to a semi-purified diet containing TAG oil for 21 d. After assignment into two groups, pair-matched by serum TAG concentrations (range 6.1-31.6 mmol/l), the cats were fed the diet with either TAG or DAG oil for 8 d. The dietary fat source was crossed-over and presented for 8 d more. Non-fasting serum concentrations of TAG, cholesterol and NEFA were measured on days 6-8 and days 14-16. Dietary fat source (DAG v. TAG) did not significantly affect food intake (491 (sem 16) v. 486 (sem 14) kJ/kg0.67), body weight or serum concentrations (mmol/l) of TAG (37.1 (sem 4.5) v. 33.9 (sem 3.4)), cholesterol (4.8 (sem 0.3) v. 4.8 (sem 0.2)) and NEFA (1.4 (sem 0.2) v. 1.4 (sem 0.2)). The results show that for a feeding trial of 8 d, DAG oil was well accepted and tolerated by cats but did not reduce hypertriacylglycerolaemia resulting from a deficiency of LPL catalytic activity.
Datz
Craig A
CA
Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, 65211, USA. datzc@missouri.edu
Backus
Robert C
RC
Fritsche
Kevin L
KL
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002415:Cats; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000627:therapeutic use; D004075:Diglycerides / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000097:blood; D015228:Hypertriglyceridemia / Q000097:blood / Q000178:diet therapy* / Q000209:etiology; D008071:Lipoprotein Lipase / Q000172:deficiency*; D008297:Male; D010938:Plant Oils / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D004075:Diglycerides; D005230:Fatty Acids, Nonesterified; D010938:Plant Oils; D014280:Triglycerides; D002784:Cholesterol; D008071:Lipoprotein Lipase