Biosensing by densely packed and optically coupled plasmonic particle arrays.
Densely packed plasmonic particle arrays are investigated for biosensing applications. Such particle arrays exhibit interparticle optical coupling creating a strong field between the particles, which is useful for sensing purposes. The sensor properties, such as bulk sensitivity, layer sensitivity, and the depth of sensitivity are investigated with the aid of a multiple multipole program. Sensitivity to the analyte with low concentration is also examined by a dynamic adsorption processes. The detectable concentration limit of streptavidin within 3000 s in the detection system is expected from the signal-to-noise to be less than 150 pM.
Sannomiya
Takumi
T
Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Gloriastrasse 35, 8092 Zurich, Switzerland.
Sahoo
Pratap K
PK
Mahcicek
Davut I
DI
Solak
Harun H
HH
Hafner
Christian
C
Grieshaber
Dorothee
D
Vörös
Janos
J
D000327:Adsorption; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D006046:Gold / Q000737:chemistry; D007700:Kinetics; D053768:Metal Nanoparticles / Q000737:chemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods; D055095:Optics and Photonics; D012997:Solvents / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D019809:Streptavidin / Q000737:chemistry*; D020349:Surface Plasmon Resonance; D013997:Time Factors
D012997:Solvents; D006046:Gold; D019809:Streptavidin