[Mechanism of donor T cell migration and homing in the pathophysiology of acute graft-versus-host disease - review].
Migration of donor T cells to the host second lymphoid organs and homing of activated donor T cells into the target tissues play crucial role in the pathophysiology of acute graft-versus-host disease (aGVHD). More deep understanding of the mechanisms for donor T cell migration and homing reveals an important significance in preventing the initiation of aGVHD. In this review, the migration of donor T cells to host second lymphoid organs, homing of donor activated T cells into the target organs, homing of regulating T cells into target organs, the mechanisms of T cell migration and homing in process of aGVHD and its study prospects were summarised.
Sun
Li-Xia
LX
Department of Hematology, Beijing University First Hospital, Beijing 100034, China.
Ren
Han-Yun
HY
D002465:Cell Movement; D006086:Graft vs Host Disease; D006801:Humans; D016201:Receptors, Lymphocyte Homing; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*
D016201:Receptors, Lymphocyte Homing