title: Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis.
abstract: Three new antiprotozoan compounds, gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A-C showed antimalarial activity against Plasmodium falciparum with IC(50) values of 0.5-10 microg/mL, whereas gracilioether B (2) also showed antileishmanial activity.
authors.affiliation: Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Ueoka
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
authors.forename: Shizuka
authors.initials: S
authors.lastname: Kawatsu
authors.forename: Junko
authors.initials: J
authors.lastname: Yaegashi
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Kazuo
authors.initials: K
authors.lastname: Furihata
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification*; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera
chemical_list: D000962:Antimalarials; D000981:Antiprotozoal Agents; D001688:Biological Products; D005663:Furans; D006575:Heterocyclic Compounds, 3-Ring; C542747:gracilioether A; C542748:gracilioether B; C542749:gracilioether C