title: A population study of a mutation allele associated with cone-rod dystrophy in the standard wire-haired dachshund.
abstract: Cone-rod dystrophy in the standard wire-haired dachshund (SWHD) is inherited as a simple autosomal recessive trait and the recently discovered mutation is widespread within the SWHD population in Norway and other Scandinavian countries. The gene frequency was estimated to be 4.8%. On the basis of the assumption that the size of the ancestral haplotype around a mutation is inversely correlated with the number of generations since the mutation arose, we have found that the mutation is of a relatively recent origin. The conserved haplotype was found to be 8 Mb in size and therefore we estimate that the mutation arose roughly eight generations (approximately 37 years) ago. This indicates that the mutation arose after breed separation.
authors.affiliation: Department of Basic Sciences and Aquatic Medicine, Division of Genetics, Norwegian School of Veterinary Science, PO Box 8146 Dep., 0033 Oslo, Norway. anne.wiik@veths.no
authors.forename: A C
authors.initials: AC
authors.lastname: Wiik
authors.forename: S I
authors.initials: SI
authors.lastname: Thoresen
authors.forename: C
authors.initials: C
authors.lastname: Wade
authors.forename: K
authors.initials: K
authors.lastname: Lindblad-Toh
authors.forename: F
authors.initials: F
authors.lastname: Lingaas
mesh_terms: D000483:Alleles; D000818:Animals; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs / Q000235:genetics* / Q000502:physiology; D005787:Gene Frequency; D015810:Linkage Disequilibrium; D009154:Mutation; D010375:Pedigree; D012174:Retinitis Pigmentosa / Q000235:genetics / Q000662:veterinary*