title: Early organ dysfunction course, cooling time and outcome in classic heatstroke.
abstract: OBJECTIVE
  To describe the course of early organ dysfunction in a cohort of patients admitted in ICU suffering classic heatstroke.
  
  
  METHODS
  Prospective observational single-centre cohort study with a 1-year follow-up.
  
  
  METHODS
  None.
  
  
  RESULTS
  Clinical and biological data of 22 patients were analysed. Median body temperature on admission was 41.1 degrees C. Respiratory, circulatory, haematological, hepatic and renal function all deteriorated within the first 24 h of admission. ICU-mortality was 63.6%. Cooling time, serum lactate, serum cardiac troponin I and creatinine were significantly higher in non-survivors. Early ICU-mortality (within 7 days of ICU stay) was due to multiple organ failure. Late ICU-mortality was due to neurological disability.
  
  
  CONCLUSIONS
  Classic heat stroke may demonstrate a rapidly worsening organ dysfunction course leading to death even though cooling procedures and intensive care management are promptly started.
authors.affiliation: Medical Intensive Care Unit, AP-HP, Hôpital Bichat-Claude Bernard, 75018 Paris, France. sebastian.pease@bjn.aphp.fr
authors.forename: Sebastian
authors.initials: S
authors.lastname: Pease
authors.forename: Lila
authors.initials: L
authors.lastname: Bouadma
authors.forename: Nathalie
authors.initials: N
authors.lastname: Kermarrec
authors.forename: Frédérique
authors.initials: F
authors.lastname: Schortgen
authors.forename: Bernard
authors.initials: B
authors.lastname: Régnier
authors.forename: Michel
authors.initials: M
authors.lastname: Wolff
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D018883:Heat Stroke / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007036:Hypothermia, Induced; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000401:mortality / Q000503:physiopathology*; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D018570:Risk Assessment; D013997:Time Factors