Composition and biological activity of essential oil of Achillea ligustica All. (Asteraceae) naturalized in central Italy: ideal candidate for anti-cariogenic formulations.
Essential oil from flowers (FL) and vegetative parts (VP) of Achillea ligustica (Asteraceae), naturalized after cultivation in central Italy, was investigated by GC-FID and GC-MS. The most abundant components were linalool, viridiflorol, beta-pinene, 1,8-cineole and terpinen-4-ol. The antioxidant assays (DPPH and ABTS radical scavenging assays, and beta-carotene bleaching test) demonstrated a moderate activity of essential oils. The antimicrobial activity was evaluated by the broth micro-dilution method on 6 microbial strains and showed to be quite strong against the cariogenic Gram-positive Streptococcus mutans, suggesting that this essential oil could be a valid candidate for anti-cariogenic formulations. Moderate cytotoxic activity was observed in assays on four tumour cell lines by MTT assay.
Maggi
Filippo
F
University of Camerino, Faculty of Pharmacy, Department of Environmental Sciences, Section of Botany and Ecology, I-62032 Camerino, Italy.
Bramucci
Massimo
M
Cecchini
Cinzia
C
Coman
Maria M
MM
Cresci
Alberto
A
Cristalli
Gloria
G
Lupidi
Giulio
G
Papa
Fabrizio
F
Quassinti
Luana
L
Sagratini
Gianni
G
Vittori
Sauro
S
D031162:Achillea / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D045744:Cell Line, Tumor; D003731:Dental Caries / Q000188:drug therapy; D035264:Flowers; D006801:Humans; D007558:Italy; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010851:Picrates; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D013295:Streptococcus mutans / Q000187:drug effects; D013451:Sulfonic Acids; D013844:Thiazoles
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D009822:Oils, Volatile; D010851:Picrates; D010938:Plant Oils; D013451:Sulfonic Acids; D013844:Thiazoles; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl