title: Fully-automated, multi-stage hippocampus mapping in very mild Alzheimer disease.
abstract: Landmark-based high-dimensional diffeomorphic maps of the hippocampus (although accurate) is highly-dependent on rater's anatomic knowledge of the hippocampus in the magnetic resonance images. It is therefore vulnerable to rater drift and errors if substantial amount of effort is not spent on quality assurance, training, and re-training. A fully-automated, FreeSurfer-initialized large-deformation diffeomorphic metric mapping procedure of small brain substructures, including the hippocampus, has been previously developed and validated in small samples. In this report, we demonstrate that this fully-automated pipeline can be used in place of the landmark-based procedure in a large-sample clinical study to produce similar statistical outcomes. Some direct comparisons of the two procedures are also presented.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. leiwang1@northwestern.edu
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Ali
authors.initials: A
authors.lastname: Khan
authors.forename: John G
authors.initials: JG
authors.lastname: Csernansky
authors.forename: Bruce
authors.initials: B
authors.lastname: Fischl
authors.forename: Michael I
authors.initials: MI
authors.lastname: Miller
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
authors.forename: M Faisal
authors.initials: MF
authors.lastname: Beg
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D000704:Analysis of Variance; D001331:Automation; D001931:Brain Mapping; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008953:Models, Anatomic; D016017:Odds Ratio; D009929:Organ Size; D012984:Software