Improved properties of incorporated chitosan film with ethyl cellulose microspheres for controlled release.
In this article, to discover an innovative drug release system, ciprofloxacin hydrochloride-loaded blending films of chitosan (CS)/ethyl cellulose (EC) microspheres were prepared. Two steps were adopted in the film forming process. The first was formation of the drug-loaded EC microspheres in CS solution by solvent remove/solvent evaporation methods; then, the composite films were made by casting and solvent evaporation. The results were that the drug-loaded round EC microspheres dispersed asymmetrically in the CS films and largely improved the release time. Moreover, the drug-loaded blending film containing 0.5 g EC microspheres prepared at 90 degrees C showed highlighted extended release property. The drug was stable in the blending films, which expressed good cytocompatibility proved by MTT test. The film should be a promising carrier for controlled and extended drug release system in pharmaceutical applications.
Shi
Pujiang
P
The Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China.
Zuo
Yi
Y
Zou
Qin
Q
Shen
Juan
J
Zhang
Li
L
Li
Yubao
Y
Morsi
Yos S
YS
D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D004355:Drug Stability; D008863:Microspheres; D012997:Solvents / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012997:Solvents; D002939:Ciprofloxacin; C013517:ethyl cellulose; D002482:Cellulose; D048271:Chitosan