ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization.
Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at <igrid-ext.cryst.bbk.ac.uk/immunogrid>.
Pappalardo
Francesco
F
Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, HIM 401, Boston, MA 02115, USA.
Halling-Brown
Mark D
MD
Rapin
Nicolas
N
Zhang
Ping
P
Alemani
Davide
D
Emerson
Andrew
A
Paci
Paola
P
Duroux
Patrice
P
Pennisi
Marzio
M
Palladini
Arianna
A
Miotto
Olivo
O
Churchill
Daniel
D
Rossi
Elda
E
Shepherd
Adrian J
AJ
Moss
David S
DS
Castiglione
Filippo
F
Bernaschi
Massimo
M
Lefranc
Marie-Paule
MP
Brunak
Søren
S
Motta
Santo
S
Lollini
Pier-Luigi
PL
Basford
Kaye E
KE
Brusic
Vladimir
V
D019295:Computational Biology / Q000379:methods; D003199:Computer Systems; D003628:Database Management Systems; D016208:Databases, Factual; D015195:Drug Design; D006801:Humans; D007107:Immune System / Q000502:physiology*; D008285:Major Histocompatibility Complex; D008954:Models, Biological; D018511:Systems Integration; D014612:Vaccines
D014612:Vaccines