Galactorrhea with metoclopramide use in the neonatal unit.
We report a 3(1/2)-month-old infant with trisomy 21 presenting with galactorrhea in the neonatal intensive care unit (NICU). Endocrine work-up showed a high prolactin level (64.4 ng ml(-1)--normal: 0.5 to 30 ng ml(-1)). Cessation of therapy with metoclopramide (0.2 mg kg(-1) per dose q 6 h) resulted in the resolution of galactorrhea with a decrease in serum prolactin level (20.1 ng ml(-1)). We present this case to highlight this uncommon side effect of a commonly used medication in the NICU.
Paturi
B
B
Women and Children's Hospital of Buffalo, Buffalo, NY 14222, USA.
Ryan
R M
RM
Michienzi
K A
KA
Lakshminrusimha
S
S
D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000628:therapy; D004314:Down Syndrome / Q000175:diagnosis; D004374:Ductus Arteriosus, Patent / Q000175:diagnosis / Q000601:surgery; D005500:Follow-Up Studies; D005687:Galactorrhea / Q000139:chemically induced* / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007363:Intensive Care Units, Neonatal; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects* / Q000627:therapeutic use; D011388:Prolactin / Q000097:blood*; D018570:Risk Assessment
D011388:Prolactin; D008787:Metoclopramide