Lipid lowering activity of ethanolic extract of leaves of Aegle marmelos (Linn.) in hyperlipidaemic models of Wistar albino rats.
Lipid lowering effect of 50% ethanolic extract of the leaves of A. marmelos (Linn.) was evaluated in triton and diet induced hyperlipidaemic models of Wistar albino rats. The extract at 125 and 250 mg/kg dose levels inhibited the elevation in serum cholesterol and triglycerides levels on Triton WR 1339 administration in rats. The extract at the same dose levels significantly attenuated the elevated serum total cholesterol and triglycerides with an increase in the high-density lipoprotein cholesterol in high-fat diet- induced hyperlipidaemic rats. The standard drugs atorvastatin in the former and gemfibrozil in the latter studies showed slightly better effects.
Vijaya
C
C
Department of Pharmacology, J.S.S. College of Pharmacy, Ootacamund, India 643 001. vijak2@rediffmail.com
Ramanathan
M
M
Suresh
B
B
D045471:Aegle / Q000737:chemistry*; D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood*; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D000431:Ethanol; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood*
D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D010936:Plant Extracts; D014280:Triglycerides; D000431:Ethanol; D002784:Cholesterol