Derivation and analysis of an ordinary differential equation mean-field model for studying clinically recorded epilepsy dynamics.
In this paper we describe how an ordinary differential equation model of corticothalamic interactions may be obtained from a more general system of delay differential equations. We demonstrate that transitions to epileptic dynamics via changes in system parameters are qualitatively the same as in the original model with delay, as well as demonstrating that the onset of epileptic activity may arise due to regions of bistability. Hence, the model presents in one unique framework, two competing theories for the genesis of epileptiform activity. Similarities between model transitions and clinical data are presented and we argue that statistics obtained from, and a parameter estimation of this model may be a potential means of classifying and predicting the onset and offset of seizure activity.
Marten
Frank
F
Department of Engineering Mathematics, University of Bristol, Bristol, BS8 1TR, United Kingdom.
Rodrigues
Serafim
S
Suffczynski
Piotr
P
Richardson
Mark P
MP
Terry
John R
JR
D002540:Cerebral Cortex / Q000503:physiopathology*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009434:Neural Pathways / Q000503:physiopathology; D013788:Thalamus / Q000503:physiopathology*