title: [Virilizing adrenal ganglioneuroma : A rare differential diagnosis in testosterone secreting adrenal tumours].
abstract: Testosterone secreting tumours of the adrenal glands are usually adrenal carcinomas or adenomas. Here we report the rare case of an adrenal ganglioneuroma with ectopic Leydig cells, a so-called virilizing adrenal ganglioneuroma. Clinically it is characterized by symptoms of virilization, histologically by the occurrence of a population of eosinophilic cells. In the absence of crystalloids of Reinke this cell population can be identified as Leydig cells based on positive immunohistochemical staining of inhibin and calretinin.
authors.affiliation: Institut für Pathologie, RWTH Aachen, Deutschland.
authors.forename: N T
authors.initials: NT
authors.lastname: Gaisa
authors.forename: G
authors.initials: G
authors.lastname: Klöppel
authors.forename: B
authors.initials: B
authors.lastname: Brehmer
authors.forename: J
authors.initials: J
authors.lastname: Neulen
authors.forename: P
authors.initials: P
authors.lastname: Stephan
authors.forename: R
authors.initials: R
authors.lastname: Knüchel
authors.forename: A
authors.initials: A
authors.lastname: Donner
mesh_terms: D000302:Adrenal Cortex / Q000473:pathology; D000307:Adrenal Gland Diseases / Q000473:pathology / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D000315:Adrenalectomy; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D064032:Calbindin 2; D002828:Choristoma / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005729:Ganglioneuroma / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007265:Inhibins / Q000032:analysis; D010535:Laparoscopy; D007985:Leydig Cells; D008297:Male; D064030:S100 Calcium Binding Protein G / Q000032:analysis; D013739:Testosterone / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D014770:Virilism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C576764:CALB2 protein, human; D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G; D013739:Testosterone; D007265:Inhibins