title: Synthesis of yashabushidiol and its analogues and their cytotoxic activity against cancer cell lines.
abstract: A total synthesis of yashabushidiol (1a), a linear diarylheptanoid having 1,3- diol system and its analogues has been achieved by alkynylation of 3-hydroxy-5-phenyl pentanal with substituted phenyl acetylenes. All the compounds have shown significant anti-proliferative activity on human leukemia (THP-1, U-937) and melanoma (A-375) cell lines. Compounds 2a and 2b were found to be most potent with an IC(50) of 12.82 microg/mL and 12.62 microg/mL, respectively, on THP-1 leukemia cell line.
authors.affiliation: Organic Division-I, Natural Products Laboratory, Indian Institute of Chemical Technology, Hyderabad, India.
authors.forename: M
authors.initials: M
authors.lastname: Narasimhulu
authors.forename: T
authors.initials: T
authors.lastname: Srikanth Reddy
authors.forename: K
authors.initials: K
authors.lastname: Chinni Mahesh
authors.forename: A
authors.initials: A
authors.lastname: Sai Krishna
authors.forename: J
authors.initials: J
authors.lastname: Venkateswara Rao
authors.forename: Y
authors.initials: Y
authors.lastname: Venkateswarlu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006536:Heptanes / Q000138:chemical synthesis* / Q000633:toxicity; D006801:Humans; D010636:Phenols / Q000138:chemical synthesis* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D006536:Heptanes; D010636:Phenols; C542049:yashabushidiol