The airway vasculature: recent advances and clinical implications.
It is increasingly recognised that the airway circulation plays an important role in airway diseases, either through a change in blood flow or through microvascular leakage. Most of the information available regarding the anatomy and physiology of bronchial blood flow and its regulation has necessarily derived from animal studies. However, there have recently been important advances in understanding airway blood flow in airway disease in humans through the development of non-invasive methods and in the quantification of microvascular leakage using plasma markers. These studies have shown that bronchial blood flow is increased in patients with asthma but not in those with chronic obstructive pulmonary disease, confirming previous pathology investigations. Changes in bronchial blood flow may in part reflect the generation of new vascular vessels, a process known as "angiogenesis" which is caused by airway inflammation. Angiogenesis and the resulting plasma leak affect airway physiology, drug clearance and its bioavailability. This review discusses the anatomy, physiology and regulation of bronchial blood flow in the normal and diseased lung, In addition, it analyses the effect of current medical treatment and discusses the potential use of new anti-angiogenesis medications. The development of non-invasive assessment of bronchial blood flow and the study of angiogenesis have provided a tool to investigate airway physiology in vivo; these advances will contribute to a better understanding of inflammatory airway diseases as well as the implication of these findings to management.
Paredi
P
P
National Heart and Lung Institute, London, UK. p.paredi@ic.ac.uk
Barnes
P J
PJ
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D001980:Bronchi / Q000033:anatomy & histology / Q000098:blood supply* / Q000503:physiopathology; D001981:Bronchial Arteries / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D008833:Microcirculation / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology; D042764:Receptors, TIE / Q000037:antagonists & inhibitors; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014680:Veins / Q000033:anatomy & histology / Q000502:physiology
D000305:Adrenal Cortex Hormones; D000318:Adrenergic beta-Agonists; D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A; D042764:Receptors, TIE