title: Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy.
abstract: We describe an application of plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia in tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom and laboratory rats. Temperature distributions on the animal skin surface at hypodermic and intramuscular injection of gold nanoparticle suspensions and affectations by the laser radiation are measured in vivo with a thermal imaging system. The results of temperature measurements are compared with tissue histology.
authors.affiliation: Saratov State University, Department of Optics and Biophotonics, 83 Astrakhanskaya, Saratov 410012, Russia.
authors.forename: Georgy S
authors.initials: GS
authors.lastname: Terentyuk
authors.forename: Galina N
authors.initials: GN
authors.lastname: Maslyakova
authors.forename: Leyla V
authors.initials: LV
authors.lastname: Suleymanova
authors.forename: Nikolai G
authors.initials: NG
authors.lastname: Khlebtsov
authors.forename: Boris N
authors.initials: BN
authors.lastname: Khlebtsov
authors.forename: Garif G
authors.initials: GG
authors.lastname: Akchurin
authors.forename: Irina L
authors.initials: IL
authors.lastname: Maksimova
authors.forename: Valery V
authors.initials: VV
authors.lastname: Tuchin
mesh_terms: D003198:Computer Simulation; D006046:Gold / Q000528:radiation effects* / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007834:Lasers; D008954:Models, Biological; D053758:Nanoparticles / Q000528:radiation effects* / Q000627:therapeutic use*; D010789:Phototherapy / Q000379:methods*
chemical_list: D006046:Gold