Pregnancy and breast cancer: when they collide.
Women of childbearing age experience an increased breast cancer risk associated with a completed pregnancy. For younger women, this increase in breast cancer risk is transient and within a decade after parturition a cross over effect results in an ultimate protective benefit. The post-partum peak of increased risk is greater in women with advanced maternal age. Further, their lifetime risk for developing breast cancer remains elevated for many years, with the cross over to protection occurring decades later or not at all. Breast cancers diagnosed during pregnancy and within a number of years post-partum are termed pregnancy-associated or PABC. Contrary to popular belief, PABC is not a rare disease and could affect up to 40,000 women in 2009. The collision between pregnancy and breast cancer puts women in a fear-invoking paradox of their own health, their pregnancy, and the outcomes for both. We propose two distinct subtypes of PABC: breast cancer diagnosed during pregnancy and breast cancer diagnosed post-partum. This distinction is important because emerging epidemiologic data highlights worsened outcomes specific to post-partum cases. We reported that post-partum breast involution may be responsible for the increased metastatic potential of post-partum PABC. Increased awareness and detection, rationally aggressive treatment, and enhanced understanding of the mechanisms are imperative steps toward improving the prognosis for PABC. If we determine the mechanisms by which involution promotes metastasis of PABC, the post-partum period can be a window of opportunity for intervention strategies.
Lyons
Traci R
TR
Department of Medicine, Division of Medical Oncology, University of Colorado Denver, Aurora, CO 80045, USA.
Schedin
Pepper J
PJ
Borges
Virginia F
VF
D000328:Adult; D001940:Breast / Q000502:physiology; D001943:Breast Neoplasms / Q000145:classification / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D004198:Disease Susceptibility; D016326:Extracellular Matrix Proteins / Q000502:physiology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D015994:Incidence; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D007774:Lactation; D008954:Models, Biological; D009362:Neoplasm Metastasis; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology*; D011379:Prognosis; D011644:Puerperal Disorders / Q000453:epidemiology* / Q000209:etiology; D012306:Risk; D013997:Time Factors; D055815:Young Adult
D016326:Extracellular Matrix Proteins; D012739:Gonadal Steroid Hormones; D036341:Intercellular Signaling Peptides and Proteins