[Surgical treatment for early Barrett cancer].
Adenocarcinomas in Barrett's oesophagus are more commonly diagnosed at an early stage due to effective surveillance programmes. Subtotal oesophagectomy with extended lymphadenectomy is considered the best curative treatment for patients with early adenocarcinoma of the oesophagus. However, such treatment carries substantial morbidity and compromises quality of life. Limited resection, minimal invasive surgical procedures or endoscopic mucosal ablation have been proposed as less invasive alternatives. A comparison of treatment associated morbidity, recurrence rate, long-term survival and functional outcome suggests that none of these alternative methods can be universally recommended. An individualized strategy should be employed based on staging (tumour penetration into the mucosa/submucosa, presence of lymph node metastasis), multicentricity, length of the underlying Barrett mucosa and risk factors of the patient. Surgical resection (radical or limited) remains the treatment of choice for tumours invading the submucosa, or multicentric and recurrent tumours after endoscopic mucosectomy.
Horváth
Ors Péter
OP
Pécsi Tudományegyetem, Klinikai Központ Sebészeti Klinika, Pécs, Hungary. ophorvath@iseb.pote.hu
D000230:Adenocarcinoma / Q000175:diagnosis / Q000601:surgery; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D055088:Early Detection of Cancer; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods*; D004945:Esophagoscopy; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011788:Quality of Life; D021701:Sentinel Lymph Node Biopsy; D015996:Survival Rate; D014630:Vagus Nerve / Q000601:surgery