title: The impact of ventricular catheter impregnated with antimicrobial agents on infections in patients with ventricular catheter: interim report.
abstract: BACKGROUND
  Previous prospective study in our unit had shown that the use of dual antibiotic prophylaxis in patients with external ventricular drain was associated with decreased incidence of cerebrospinal fluid infection but complicated with opportunistic extracranial infection. In recent years, cerebrospinal fluid shunt catheters impregnated with antimicrobial agents have become available. Theoretically, these catheters provide antibiotic prophylaxis locally without the associated complications of systemic opportunistic infection.
  
  
  METHODS
  We carried out a prospective randomized, controlled clinical trial in a regional neurosurgical center in Hong Kong. We recruited patients admitted for emergency neurosurgical operation after informed consent was obtained from next-of-kin. Eligible patients were randomized to receive an antibiotic-impregnated ventricular catheter or plain ventricular catheter Dual prophylactic antibiotic coverage was given to the patients randomized for plain ventricular catheter only. Patients who received antibiotic impregnanted catheters were not treated with systematic prophylactic antibiotics. Here we present the analysis of 110 patients, recruited over a 2-year period, to receive antibiotic-impregnanted ventricular catheters versus non-impregnated ventricular cathethers with prophylactic antibiotic coverage.
  
  
  RESULTS
  Fifty-two patients were randomized to antibiotic-impregnated ventricular catheter with no systemic antibiotic prophylaxis (Group A) and 58 patients were randomized to plain ventricular catheters with prophylactic dual antibiotics (Group B). There was no ventriculostomy-related infection in either groups of patients. There was also no statistical significant difference in incidences of extracranial infections between the two groups, p = 0.617.
  
  
  CONCLUSIONS
  In this analysis, antibiotic-impregnation of ventricular catheters was as effective as systemic antibiotics in the prevention of ventriculostomy infections, with the potential advantage of avoiding the systemic side-effects of prophylactic antibiotics.
authors.affiliation: Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
authors.forename: George K C
authors.initials: GK
authors.lastname: Wong
authors.forename: W S
authors.initials: WS
authors.lastname: Poon
authors.forename: Stephanie C P
authors.initials: SC
authors.lastname: Ng
authors.forename: Margaret
authors.initials: M
authors.lastname: Ip
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D014946:Wound Infection / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents