title: [Evaluation on in vitro release of Chinese medicinal compound sustained release preparations using multi-index chromatographic fingerprint].
abstract: OBJECTIVE
  To establish a method to evaluate the in vitro release of Chinese medicinal compound sustained release preparations using multi-index chromatographic fingerprint.
  
  
  METHODS
  With the Chinese medicinal compound Jiangya sustained tablets as model preparation, the in vitro cumulative release of the main component flavones and fingerprint were determined by HPLC fingerprint. Aacacetin, rutin, luteolin, fingerprint were determined simultaneously and used to calculate the in vitro cumulative release of the tablets.
  
  
  RESULTS
  Aacacetin, rutin, luteolin, and the fingerprint had different cumulative release.
  
  
  CONCLUSIONS
  Multi-index chromatographic fingerprint can reflect different content of multi components of preparations and can be used in the evaluation on in vitro release of the sustained release preparations of Chinese medicinal compound. The method is simple, rapid, and of multi information.
authors.affiliation: Institute of Biomedicine, Tsinghua University, Beijing 100084, China. liuqf@mail.tsinghua.edu.cn
authors.forename: Qingfei
authors.initials: Q
authors.lastname: Liu
authors.forename: Yiming
authors.initials: Y
authors.lastname: Wang
authors.forename: Guoan
authors.initials: G
authors.lastname: Luo
mesh_terms: D002845:Chromatography; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism*; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal