title: In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube.
abstract: A novel murine model of non-typeable Haemophilus influenzae (NTHi) pneumonia was established. A plastic tube was inserted into the trachea 7 days before bacterial inoculation. Numbers of NTHi recovered from the lungs and trachea were determined for 7 days. Histologically, bronchioles and adjacent alveoli in the intubation group were filled with numerous inflammatory cells. The efficacy of sitafloxacin was compared with ciprofloxacin using the new murine pneumonia model. The data suggest that sitafloxacin displays equivalent efficacy to ciprofloxacin against H. influenzae pneumonia. This new murine NTHi pneumonia model appears useful not only for in vivo evaluation of antibiotics but also for analysis of the pathogenesis of H. influenzae pneumonia.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nakamura
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Nobuko
authors.initials: N
authors.lastname: Araki
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Morinaga
authors.forename: Koichi
authors.initials: K
authors.lastname: Izumikawa
authors.forename: Masafumi
authors.initials: M
authors.lastname: Seki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kakeya
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Shimeru
authors.initials: S
authors.lastname: Kamihira
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D055745:Bronchioles / Q000382:microbiology / Q000473:pathology; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D006192:Haemophilus Infections / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology; D006193:Haemophilus influenzae / Q000187:drug effects*; D007442:Intubation, Intratracheal; D008297:Male; D051379:Mice; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000209:etiology; D011650:Pulmonary Alveoli / Q000382:microbiology / Q000473:pathology; D013997:Time Factors; D014132:Trachea / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; C076246:sitafloxacin