title: In vitro activity of voriconazole against Mexican oral yeast isolates.
abstract: Oral candidiasis is the most prevalent complication in HIV-infected and AIDS patients. Topical antifungal treatment is useful for the initial episodes of oral candidiasis, but most patients suffer more than one episode and fluconazole or itraconazole can help in the management, and voriconazole may represent a useful alternative agent for the treatment of recalcitrant oral and oesophageal candidiasis. The aim of this research was to study the in vitro activity of voriconazole and fluconazole against Mexican oral isolates of clinically relevant yeast. The in vitro susceptibility of 187 oral yeast isolates from HIV-infected and healthy Mexicans was determined for fluconazole and voriconazole by the M44-A disc diffusion method. At 24 h, fluconazole was active against 179 of 187 isolates (95.7 %). Moreover, a 100% susceptibility to voriconazole was observed. Voriconazole and fluconazole are highly active in vitro against oral yeast isolates. This study provides baseline data on susceptibilities to both antifungal agents in Mexico.
authors.affiliation: Laboratorio de Micología Médica, Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco-Euskal Herriko Unibertsitatea, Bilbao, Spain.
authors.forename: Luis Octavio
authors.initials: LO
authors.lastname: Sánchez Vargas
authors.forename: Elena
authors.initials: E
authors.lastname: Eraso
authors.forename: Alfonso Javier
authors.initials: AJ
authors.lastname: Carrillo-Muñoz
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Aguirre
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Gaitán-Cepeda
authors.forename: Guillermo
authors.initials: G
authors.lastname: Quindós
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000382:microbiology*; D015725:Fluconazole / Q000494:pharmacology; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008800:Mexico; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology; D010614:Pharynx / Q000382:microbiology; D011743:Pyrimidines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D015725:Fluconazole; D065819:Voriconazole