Prostaglandin E2 synthases in neurologic homeostasis and disease.
Prostaglandin E(2) synthases (PGES) currently comprise a group of three structurally and biologically distinct molecules. These enzymes are part of an important and complex paracrine signaling system involved in a wide range of biological processes. This review focuses on the normal physiological and pathological roles of these enzymes in the nervous system. Specific topics include the role of PGES(s) in fever and sickness behavior, inflammatory pain, and neural disease. Although the field is in its early stages, ongoing development of selective PGES inhibitors for possible use in people creates a significant need for more fully understanding the biological roles of these important enzymes.
O'Banion
M Kerry
MK
Department of Neurobiology & Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. kerry_obanion@urmc.rochester.edu
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000473:pathology; D006706:Homeostasis; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism; D009422:Nervous System Diseases / Q000201:enzymology*; D010146:Pain / Q000201:enzymology / Q000473:pathology; D000071876:Prostaglandin-E Synthases
D007527:Isoenzymes; D019746:Intramolecular Oxidoreductases; D000071876:Prostaglandin-E Synthases