[Activation processes in the lymphocytes of patients with latent sensitization].
Latent sensitization is a risk factor of a clinically manifest atopic reaction. Investigation of a phenotypic composition of lymphocytes reveals function of the immune system in this condition. Indirect fluorescence assessed differential and activation lymphocyte antigens (CD4, CD3, CD8, CD16, CD20 and CD25, CD71, HLA-DR, CD95, CD23, CD54, respectively) in 15 patients with latent sensitization, 32 patients with atopic bronchial asthma and 22 healthy donors. The immune system demonstrated definite activation with involvement ofT- and B-links of the immune system. Lymphocyte activation in latent sensitization and bronchial asthma differs by high expression of CD95 apoptosis trigger receptor. Enhancement of Fas-mediated lymphocyte apoptosis may inhibit IgE synthesis and atopic pathology manifestation.
Poriadin
G V
GV
Orshanko
A M
AM
Salmasi
Zh M
ZhM
Latysheva
T V
TV
Kazimirskiĭ
A N
AN
D000328:Adult; D000485:Allergens / Q000276:immunology; D015703:Antigens, CD / Q000097:blood / Q000276:immunology; D001249:Asthma / Q000097:blood / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000097:blood / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011058:Pollen / Q000276:immunology; D012882:Skin Tests
D000485:Allergens; D015703:Antigens, CD; D007073:Immunoglobulin E