title: [Expression of vascular cell adhesion molecule-1 in patients with multiple myeloma and its significance].
abstract: In order to investigate the expression of vascular cell adhesion molecule-1 (VCAM-1) in patients with multiple myeloma and its significance, the expression of VCAM-1 in 23 patients were detected by reverse transcription-PCR (RT-PCR) and then compared with that in normal control. The results showed that the expression of VCAM-1 in patients with newly diagnosed and relapsed/refractory multiple myeloma was much higher than that in normal control and in patients reached plateau stage (p < 0.05). There was no statistically significant difference between newly diagnosed and relapsed/refractory patients (p > 0.05). It is concluded that the expression of VCAM-1 in patients with multiple myeloma is abnormal, which may be an important factor for the pathogenesis of multiple myeloma.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Zeng-Yan
authors.initials: ZY
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Lu
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Chen
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Wang
authors.forename: Shi-Feng
authors.initials: SF
authors.lastname: Lu
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000378:metabolism* / Q000473:pathology*; D009367:Neoplasm Staging; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism*
chemical_list: D019010:Vascular Cell Adhesion Molecule-1