[Bone fracture and the healing mechanisms. The effect of human parathyroid hormone on fracture healing].
We reviewed the effect of human parathyroid hormone (hPTH) on fracture healing. In rodent fracture model, intermittent treatment of PTH accelerated the healing process as evidenced by earlier replacement of woven bone to lamellar bone, increased new cortical shell formation, and increased the ultimate load. In cynomolgus monkey fracture model, PTH accelerates the natural fracture healing process by shrinking callus size and increasing degree of mineralization of the fracture callus, thereby restoring intrinsic material properties.
Komatsubara
Satoshi
S
Department of Orthopedic Surgery, Faculty of medicine, Kagawa University.
Mashiba
Tasuku
T
Mori
Satoshi
S
D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects; D017102:Fracture Healing / Q000187:drug effects*; D050723:Fractures, Bone / Q000503:physiopathology; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy; D010281:Parathyroid Hormone / Q000494:pharmacology* / Q000627:therapeutic use*; D013268:Stimulation, Chemical
D010281:Parathyroid Hormone