title: Synthesis of spiroannulated oligopyrrole macrocycles derived from lithocholic acid.
abstract: Two new steroidal spiroannulated calix[4]pyrroles 5 and 10, derived from bile acids (lithocholate), were prepared by the acid catalyzed condensation of methyl-3,3-bis(pyrrol-2-yl)-5beta-cholan-24-oate 3 with carbonyl compounds and with 2,2'-propane-2,2-diylbis(1H-pyrrole), respectively. The new compounds were fully characterized by physicochemical methods.
authors.affiliation: Department of Chemistry, J.E. Purkyne University, Ceské mládeze 8, 400 96 Ustí nad Labem, Czech Republic.
authors.forename: Nguyen Thi Thu
authors.initials: NT
authors.lastname: Huong
authors.forename: Petra
authors.initials: P
authors.lastname: Klímková
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sorrenti
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mancini
authors.forename: Pavel
authors.initials: P
authors.lastname: Drasar
mesh_terms: D002942:Circular Dichroism; D008095:Lithocholic Acid / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D011758:Pyrroles / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D047028:Macrocyclic Compounds; D011758:Pyrroles; D013141:Spiro Compounds; D008095:Lithocholic Acid