Nontraditional signaling mechanisms of lipoprotein receptors.
The low-density lipoprotein receptor family consists of a large number of single transmembrane proteins that are involved both in endocytosis of extracellular ligands and in intracellular signaling processes. New evidence ties these receptors to the transactivation of Trk receptors. Thus, this single receptor family demonstrates several distinct mechanisms for transducing information across the plasma membrane.
Rebeck
G William
GW
Department of Neuroscience, Georgetown University, Washington, DC 20007, USA. gwr2@georgetown.edu
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D011973:Receptors, LDL / Q000502:physiology; D018110:Receptors, Lipoprotein / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D008565:Membrane Proteins; D011973:Receptors, LDL; D018110:Receptors, Lipoprotein