CuBr-catalyzed oxidative difluoromethylation of tertiary amines with difluoroenol silyl ethers.
CuBr-catalyzed oxidative difluoromethylation of readily available tertiary amines with difluoroenol silyl ethers was performed under mild conditions to afford beta-amine-alpha,alpha-difluoro ketones.
Chu
Lingling
L
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Zhang
Xingang
X
Qing
Feng-Ling
FL
D000588:Amines / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry*
D000588:Amines; D001965:Bromides; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D012821:Silanes; C408079:cupric bromide; D003300:Copper