title: Hansen's disease with HIV: a case of immune reconstitution disease.
abstract: Immune reconstitution inflammatory syndrome (IRIS) is an acute symptomatic expression of a latent infection during the recovery of the immune system usually as a response to antiretroviral therapy (ART). Opportunistic infections can trigger IRIS. Hansen's disease is an infection caused by Mycobacterium leprae (M. leprae). There have been a limited number of case reports reporting the presentation of the co-infection of HIV and M. leprae. We report an unique case of IRIS in a patient co-infected with HIV and M. leprae presenting as an exacerbation of his Hansen's Disease where the patient's skin lesions progressed from borderline tuberculoid to lepromatous leprosy following ART administration.
authors.affiliation: Department of Medicine, John A Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, HI 96813, USA. dominicc@hawaii.edu
authors.forename: Dominic
authors.initials: D
authors.lastname: Chow
authors.forename: Leila
authors.initials: L
authors.lastname: Okinaka
authors.forename: Scott
authors.initials: S
authors.lastname: Souza
authors.forename: Cecilia
authors.initials: C
authors.lastname: Shikuma
authors.forename: Alan
authors.initials: A
authors.lastname: Tice
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000276:immunology; D015897:Comorbidity; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000453:epidemiology*; D007918:Leprosy / Q000453:epidemiology* / Q000276:immunology; D008297:Male
chemical_list: D044966:Anti-Retroviral Agents