title: Acetaldehyde stimulates ethanol-stressed Saccharomyces cerevisiae, grown on various carbon sources.
abstract: The ability of added acetaldehyde to stimulate growth in ethanol-stressed Saccharomyces cerevisiae while grown on non-fermentable substrates (ethanol, glycerol) is reported. The addition of acetaldehyde to ethanol-stressed yeast grown on either ethanol or glycerol led to a significant decrease in lag time of 67 and 45 %, respectively (p = 0.000) and an increase in the specific growth rate (0.008-0.038/h and 0.060-0.074/h, respectively). The stimulatory effect of acetaldehyde could be mimicked by the addition of propionaldehyde. Results, following metabolic tracing of the added stimulants, question the previously held notion that the acetaldehyde effect in S. cerevisiae is fully redox related.
authors.affiliation: Institute for Food and Crop Science, University of Ballarat, Victoria, Australia.
authors.forename: B
authors.initials: B
authors.lastname: Hucker
authors.forename: F
authors.initials: F
authors.lastname: Vriesekoop
mesh_terms: D000079:Acetaldehyde / Q000494:pharmacology*; D000447:Aldehydes / Q000494:pharmacology; D002244:Carbon / Q000378:metabolism; D003470:Culture Media / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D010084:Oxidation-Reduction; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development; D013312:Stress, Physiological / Q000235:genetics
chemical_list: D000447:Aldehydes; D003470:Culture Media; D000431:Ethanol; D002244:Carbon; C005556:propionaldehyde; D000079:Acetaldehyde; D005947:Glucose; D005990:Glycerol