title: The use of bone morphogenetic protein in lumbar spine surgery.
abstract: Creating a solid lumbar spinal fusion remains a challenge. Despite advances in fixation, a pseudarthrosis still may occur. Recently, attention has focused on creating a more biologically favorable environment to enhance fusion rate. Bone morphogenetic proteins (BMPs) are a group of secreted growth factors that belong to the transforming growth factor-beta superfamily. Two recombinant BMP proteins, rhBMP-2 and rhBMP-7 (OP-1), have been used successfully in preclinical and clinical trials and are commercially available for clinical applications.
authors.affiliation: Department of Orthopedic Surgery, Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Rihn
authors.forename: Charley
authors.initials: C
authors.lastname: Gates
authors.forename: Steven D
authors.initials: SD
authors.lastname: Glassman
authors.forename: Frank M
authors.initials: FM
authors.lastname: Phillips
authors.forename: James D
authors.initials: JD
authors.lastname: Schwender
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Albert
mesh_terms: D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use*; D055419:Bone Morphogenetic Protein 7 / Q000627:therapeutic use*; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology / Q000601:surgery*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013123:Spinal Fusion / Q000379:methods*
chemical_list: D055396:Bone Morphogenetic Protein 2; D055419:Bone Morphogenetic Protein 7; D011994:Recombinant Proteins