Differential patterns of immune escape at Tat-specific cytotoxic T cell epitopes in pigtail macaques.
Cytotoxic T lymphocyte responses to conserved proteins such as Gag within HIV- or SIV-infected hosts can facilitate partial control of viremia. However, the utility of targeting variable viral proteins by CTL responses is unclear. We studied CTL responses to regulatory and accessory proteins of SIV in pigtail macaques. The regulatory and accessory proteins were the most commonly targeted proteins by CTL responses from pigtail macaques. We identified 2 novel Tat-specific CTL responses that were both restricted by the Mane-A10 allele. Viral escape at one of the Tat epitopes, KSA10, was slower in comparison to another Tat epitope KVA10. The kinetics of escape of the KSA10 Tat epitope were more similar to an immunodominant KP9 Gag epitope also restricted by Mane-A10. Our results suggest that some regulatory or accessory CTL epitopes may be useful targets for vaccination against HIV.
Mason
Rosemarie D
RD
Department of Microbiology and Immunology, University of Melbourne 3010, Australia.
De Rose
Robert
R
Kent
Stephen J
SJ
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000235:genetics / Q000276:immunology*; D015696:Gene Products, tat / Q000276:immunology*; D007111:Immunity, Cellular / Q000276:immunology; D008254:Macaca nemestrina / Q000235:genetics / Q000276:immunology* / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000821:virology; D054334:Viral Regulatory and Accessory Proteins / Q000276:immunology
D018984:Epitopes, T-Lymphocyte; D015696:Gene Products, tat; D012367:RNA, Viral; D054334:Viral Regulatory and Accessory Proteins