One-pot multicomponent synthesis of 1-aryl-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamides: an easy procedure for combinatorial chemistry.
A convenient synthetic protocol was elaborated for creation of combinatorial libraries of 1-(R(1)-phenyl)-5-methyl-N-R(2)-1H-1,2,3-triazole-4-carboxamides. As starting materials, commercially available or readily prepared azides, amines, and diketene were selected for the reaction which has proceeded in a one-pot system with high yields and in short time.
Pokhodylo
Nazariy T
NT
Department of Organic Chemistry, Ivan Franko National University of Lviv, Lviv, Ukraine. pokhodylo@gmail.com
Matiychuk
Vasyl S
VS
Obushak
Mykola D
MD
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D001386:Azides / Q000138:chemical synthesis / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry / Q000191:economics; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
C542081:1-(R1-phenyl)-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamide; D000588:Amines; D001386:Azides; D007783:Lactones; D054852:Small Molecule Libraries; D014230:Triazoles; C004773:diketene