title: [Direct cell-cell communications and social behavior of cells in mammals, protists, and bacteria. Possible causes of multicellularity].
abstract: Comparison of current data on direct cell-cell communications in mammals, protists, and bacteria suggests that the emergence of the signaling systems of self-organization underlay the emergence of multicellular organisms. Biogenic amines, regulators of coordinated behavior and aggregation in bacteria, have been found in protists and multicellular organisms. In metazoans, biogenic amines have become specific neurotransmitters. At the same time, the studies on synchronization of protein synthesis rhythm in mammalian cell cultures demonstrated that noradrenaline and serotonin have conserved their ancient function of cell-cell cooperation in mammals, which is manifested as coordinated social behavior of cells in population in the case of bacteria and multicellular organisms.
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Brodskiĭ
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D018407:Bacterial Physiological Phenomena; D001679:Biogenic Amines / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology*; D056890:Eukaryota / Q000502:physiology*; D008322:Mammals / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism
chemical_list: D001679:Biogenic Amines; D018377:Neurotransmitter Agents