Plasmodium fieldi: observations on the Hackeri and ABI strains in Macaca mulatta monkeys and mosquitoes.
Macaca mulatta monkeys infected with the Hackeri strain of Plasmodium fieldi had maximum parasite counts ranging from 1,300 to 301,320/microL. In 43 intact animals infected with the ABI strain, the maximum parasite counts ranged from 672 to 57,189/microL (median = 15,100/microL); in 46 splenectomized monkeys, the maximum parasite count ranged from 660 to 350,000/microL (median = 52,245/microL). Transmission through Anopheles dirus mosquitoes was obtained on 11 occasions with pre-patent periods of 9-14 days. Relapses occurred between two and eight times during a 1-year period. P. fieldi has potential for testing prophylactic and radical curative drugs.
Collins
William E
WE
Division of Parasitic Diseases and Scientific Resources Branch, National Center for Vector-Borne and Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, Georgia 30333, USA. wec1@cdc.gov
Sullivan
Joann S
JS
Warren
McWilson
M
Galland
G Gale
GG
Williams
Allison
A
Barnwell
John W
JW
D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D000962:Antimalarials / Q000627:therapeutic use; D004195:Disease Models, Animal; D007303:Insect Vectors / Q000469:parasitology*; D008253:Macaca mulatta / Q000469:parasitology*; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology* / Q000635:transmission; D033661:Oocysts / Q000502:physiology; D010961:Plasmodium / Q000145:classification*; D013997:Time Factors
D000962:Antimalarials