title: [Temporal oscillations of retinal vessel diameter in healthy volunteers of different age].
abstract: OBJECTIVE
  We investigated whether temporal oscillations of the retinal vessel diameter, as measured with the dynamic vessel analyzer (DVA), undergo age-related changes.
  
  
  METHODS
  Vessel diameters of retinal arterial and venous segments were examined with the DVA in 28 medically healthy volunteers divided into two age groups of 14 persons each: young subjects (21-32 years) and seniors (52-70 years). Continuous temporal records of vessel diameter were mathematically evaluated and divided into high-frequency (period <1.5 s) and low-frequency (period > or =1.5 s) oscillations.
  
  
  RESULTS
  The phase difference between temporal arterial and venous vessel diameter records was higher in the young group [0.6 (0.1, 3.3)] s [median (1st quartile, 3rd quartile)] compared with the seniors [0.1 (-0.4, 0.3) s]. There was a difference in the periodicity in veins between the groups and, in seniors, between the arteries and the veins.
  
  
  CONCLUSIONS
  High-frequency oscillations of vessel diameter correspond to the heartbeat. These were expressed more in seniors. Low-frequency oscillations were well expressed in young subjects. Our results show significant age-related alterations in retinal vessel regulation.
authors.affiliation: Augenklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 München. kotliar@lrz.tum.de
authors.forename: K E
authors.initials: KE
authors.lastname: Kotliar
authors.forename: W
authors.initials: W
authors.lastname: Vilser
authors.forename: A
authors.initials: A
authors.lastname: Schmidt-Trucksäss
authors.forename: M
authors.initials: M
authors.lastname: Halle
authors.forename: I M
authors.initials: IM
authors.lastname: Lanzl
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D001683:Biological Clocks / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012171:Retinal Vessels / Q000033:anatomy & histology* / Q000502:physiology*; D055815:Young Adult