Advances in treating acute asthma exacerbations in children.
OBJECTIVE
Asthma continues to be a major chronic disease in children, and acute asthma exacerbations are common. Although the basic therapy of asthma exacerbations has not changed, recent studies have demonstrated improved outcomes with different modes of delivery of medications, improved patients' self-management of their asthma, and recognition of risk factors for severe exacerbations.


RESULTS
Recent studies in children have shown that written action plans based on symptom recognition are more effective than action plans based on peak expiratory flows. Bronchodilator administration by metered-dose inhaler is becoming the preferred therapy for treating mild-to-moderate asthma exacerbations in the emergency department, but nebulizers may still have a role in home and inpatient asthma management. High-dose inhaled corticosteroids may be as effective as oral corticosteroids for acute asthma exacerbations. A novel treatment strategy has titrated combination therapy with budesonide and formoterol for both maintenance and relief of symptoms. Lastly, the contributions of obesity and genetic variation to severe asthma exacerbations are becoming known, and noninvasive positive pressure ventilation has become an option for patients in severe asthma exacerbations.


CONCLUSIONS
Improvements in management strategies can significantly improve outcomes in children with asthma.
Schramm
Craig M
CM
Pulmonary Division, Connecticut Children's Medical Center, Hartford, CT 06106, USA. cschram@ccmckids.org
Carroll
Christopher L
CL
D000208:Acute Disease; D000280:Administration, Inhalation; D001249:Asthma / Q000628:therapy*; D002648:Child; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D017410:Practice Guidelines as Topic; D012008:Recurrence; D012121:Respiration, Artificial / Q000379:methods*; D016896:Treatment Outcome
D005938:Glucocorticoids