title: Triterpenes from Astilbe chinensis.
abstract: Six new triterpenes, 3beta,6beta-dihydroxyurs-12-en-27-oic acid (1), 3beta,6beta,24-trihydroxyurs-12-en-27-oic acid (2), 3beta,6beta,7alpha-trihydroxyurs-12-en-27-oic acid (3), 3beta-acetoxy-6beta-hydroxyurs-12-en-27-oic acid (4), 3beta,6beta,24-trihydroxyolean-12-en-27-oic acid (5), and 3beta,6beta,7alpha-trihydroxyolean-12-en-27-oic acid (6), were isolated from the rhizomes of Astilbe chinensis. Their structures were elucidated on the basis of 1D- and 2D-NMR analyses and HR-MS experiments. The isolated compounds exhibited significant cytotoxic activities against the SK-N-SH and HL-60 cell lines.
authors.affiliation: School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Jun-Yi
authors.initials: JY
authors.lastname: Hu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yao
authors.forename: Ying-Qian
authors.initials: YQ
authors.lastname: Xu
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Duan
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D014315:Triterpenes