title: Compatibility between itinerant synaptic receptors and stable postsynaptic structure.
abstract: The density of synaptic receptors in front of presynaptic release sites is stabilized in the presence of scaffold proteins, but the receptors and scaffold molecules have local exchanges with characteristic times shorter than that of the receptor-scaffold assembly. We propose a mesoscopic model to account for the regulation of the local density of receptors as quasiequilibrium. It is based on two zones (synaptic and extrasynaptic) and multilayer (membrane, submembrane, and cytoplasmic) topological organization. The model includes the balance of chemical potentials associated with the receptor and scaffold protein concentrations in the various compartments. The model shows highly cooperative behavior including a "phase change" resulting in the formation of well-defined postsynaptic domains. This study provides theoretical tools to approach the complex issue of synaptic stability at the synapse, where receptors are transiently trapped yet rapidly diffuse laterally on the plasma membrane.
authors.affiliation: Laboratoire Matières et Systèmes Complexes, Université Paris Diderot and CNRS-UMR 7057, 10 rue Alice Domont et Léonie Duquet, 75013 Paris, France.
authors.forename: Ken
authors.initials: K
authors.lastname: Sekimoto
authors.forename: Antoine
authors.initials: A
authors.lastname: Triller
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology; D007700:Kinetics; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D000199:Actins; D017981:Receptors, Neurotransmitter