Cytogenetic findings in a rare pediatric mixed glioneuronal tumor and review of the literature.
OBJECTIVE
The aim of the present study was to report the chromosomal abnormalities findings in rare pediatric mixed glioneuronal tumor (GNT), which could not be classified according to the WHO classification.


METHODS
Cytogenetic studies were performed using G-banding and fluorescence in situ hybridization (FISH) techniques.


RESULTS
Cytogenetic analyses showed a deletion of 1p as primary genetic event and gain of chromosome 7 as secondary change. Furthermore, we present a review of available cytogenetic data of 72 pediatric patients with GNT. Taken into account these data and the present case, we found that the most frequent chromosomal anomalies involved gains of chromosomes 7 (15.1%), 5 (8.2%), 1q32-qter (6.8%), 8p21-qter (6.8%), 12 (5.5%), 18 (5.5%), 20q11-qter (5.5%), and X (5.5%). Frequent losses were detected on chromosome regions 1p (8.2%) and 22q (5.5%).


CONCLUSIONS
The findings of our case combined with those of previous reports suggest that chromosomes 1 and 7 may contain candidate genes involved in the tumorigenesis of GNT.
Coccé
Mariela C
MC
Cytogenetics Laboratory, Genetics Department, Garrahan Pediatrics Hospital, Buenos Aires, Argentina. marielacocce@yahoo.com.ar
Lubieniecki
Fabiana
F
Bartuluchi
Marcelo
M
Gallego
Marta S
MS
D000293:Adolescent; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D020732:Cytogenetic Analysis; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D009380:Neoplasms, Nerve Tissue / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D017384:Sequence Deletion; D016896:Treatment Outcome