title: Life after coronary stent thrombosis.
abstract: BACKGROUND
  Coronary stent thrombosis is a catastrophic complication of percutaneous coronary intervention. There is a paucity of long-term data regarding the clinical outcome of patients who have suffered stent thrombosis.
  
  
  METHODS
  We sought to assess the long-term clinical outcome of patients who suffered de novo ST-segment elevation myocardial infarction as well as those who suffered ST-segment elevation myocardial infarction as a result of stent thrombosis. In both patient groups, major cardiac adverse events were studied during a 1-year follow-up period.
  
  
  RESULTS
  A total of 1890 consecutive patients who presented with ST-segment elevation myocardial infarction during the period January 2003 to December 2005 were studied: 1843 (97.5%) suffered de novo ST-segment elevation myocardial infarction, and 47 (2.5%) suffered ST-segment elevation myocardial infarction as a consequence of stent thrombosis. The rate of cardiogenic shock was significantly higher in the stent thrombosis group than in the de novo thrombosis group (21.3% vs 4.8%, respectively) (P<0.001). Mortality rates at 30 days (6.4% vs 8.8%) and at 1 year (17.0% vs 14.9%) showed no significant difference between the 2 groups. The repeat revascularization rate was higher among patients with post-stent thrombosis (35.7% vs 9.1%) (P<0.001), as was the major cardiovascular event rate (57.1% vs 31.2%) (P<0.001).
  
  
  CONCLUSIONS
  The long-term clinical outcome of patients who have suffered stent thrombosis is poor. Additional research is warranted to further improve therapeutic measures associated with stent thrombosis.
authors.affiliation: Semmelweis University Heart Center Budapest, Budapest, Hungary.
authors.forename: David
authors.initials: D
authors.lastname: Becker
authors.forename: Pal
authors.initials: P
authors.lastname: Maurovich-Horvat
authors.forename: György
authors.initials: G
authors.lastname: Barczi
authors.forename: György
authors.initials: G
authors.lastname: Szabó
authors.forename: Gabor
authors.initials: G
authors.lastname: Fülöp
authors.forename: Andrea
authors.initials: A
authors.lastname: Nagy
authors.forename: Levente
authors.initials: L
authors.lastname: Molnar
authors.forename: Astrid
authors.initials: A
authors.lastname: Apor
authors.forename: Eva
authors.initials: E
authors.lastname: Belicza
authors.forename: Bela
authors.initials: B
authors.lastname: Merkely
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000601:surgery*; D011446:Prospective Studies; D015607:Stents; D013927:Thrombosis / Q000473:pathology*