Mutation in bovine beta-carotene oxygenase 2 affects milk color.
beta-Carotene biochemistry is a fundamental process in mammalian biology. Aberrations either through malnutrition or potentially through genetic variation may lead to vitamin A deficiency, which is a substantial public health burden. In addition, understanding the genetic regulation of this process may enable bovine improvement. While many bovine QTL have been reported, few of the causative genes and mutations have been identified. We discovered a QTL for milk beta-carotene and subsequently identified a premature stop codon in bovine beta-carotene oxygenase 2 (BCO2), which also affects serum beta-carotene content. The BCO2 enzyme is thereby identified as a key regulator of beta-carotene metabolism.
Berry
S D
SD
ViaLactia Biosciences, Newmarket, Auckland, New Zealand.
Davis
S R
SR
Beattie
E M
EM
Thomas
N L
NL
Burrett
A K
AK
Ward
H E
HE
Stanfield
A M
AM
Biswas
M
M
Ankersmit-Udy
A E
AE
Oxley
P E
PE
Barnett
J L
JL
Pearson
J F
JF
van der Does
Y
Y
Macgibbon
A H K
AH
Spelman
R J
RJ
Lehnert
K
K
Snell
R G
RG
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D033481:Chromosomes, Mammalian / Q000235:genetics; D003116:Color; D003433:Crosses, Genetic; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D008297:Male; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D009154:Mutation; D010105:Oxygenases / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci / Q000235:genetics; D019207:beta Carotene / Q000097:blood / Q000378:metabolism
D019207:beta Carotene; D010105:Oxygenases; C093259:beta-carotene ketolase