Dimeric 1,4-benzoquinone derivatives and a resorcinol derivative from Ardisia gigantifolia.
Naturally occurring dimeric 1,4-benzoquinone derivatives, belamcandaquinones F, G, H, and I, as well as one resorcinol derivative and four known compounds, were isolated from rhizomes of Ardisia gigantifolia. Their structures were established by means of spectroscopic analyses. All compounds were tested against cell lines PC-3, EMT6, A549, Hela, RM-1, and SGC7901 for cytotoxicity in vitro. In comparison with cisplatin, compounds 5 and 6 showed a strong cytotoxicity with IC(50) values less than 30 microM for most cell lines tested.
Liu
Hongwei
H
Key Lab of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, PR China. liuhongwei60@yahoo.com.cn
Zhao
Feng
F
Yang
Ruiyun
R
Wang
Manyuan
M
Zheng
Meiqing
M
Zhao
Yisong
Y
Zhang
Xue
X
Qiu
Feng
F
Wang
Hengshan
H
D031644:Ardisia / Q000737:chemistry*; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification*; D002460:Cell Line; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification*; D021241:Spectrometry, Mass, Electrospray Ionization
D016227:Benzoquinones; D012118:Resorcinols; C004532:quinone; C031389:resorcinol