Sitafloxacin activity against Helicobacter pylori isolates, including those with gyrA mutations.
Sitafloxacin showed MICs of less than or equal to 0.5 microg/ml against 105 isolates of Helicobacter pylori, including 44 isolates with mutations in the gyrA gene. The highest MICs for garenoxacin and levofloxacin were 8 and 64 times, respectively, higher than the highest MICs observed for sitafloxacin.
Murakami
Kazunari
K
Toho University School of Medicine, 4-16-20 Omori-nishi, Ota-ku, Tokyo, Japan.
Okimoto
Tadayoshi
T
Kodama
Masaaki
M
Tanahashi
Jin
J
Fujioka
Toshio
T
Ikeda
Fumiaki
F
Muraoka
Hiroe
H
Takigawa
Motoko
M
Saika
Takeshi
T
Hasegawa
Miyuki
M
Kobayashi
Intetsu
I
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D027081:DNA Gyrase / Q000235:genetics*; D024841:Fluoroquinolones / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics*; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D009154:Mutation; D015242:Ofloxacin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D064704:Levofloxacin; C076246:sitafloxacin; D015242:Ofloxacin; D027081:DNA Gyrase; C419689:garenoxacin