[The role of calcium, calcitriol and their receptors in parathyroid regulation].
The mechanism of regulation of Parathyroid hormone (PTH) is complex, and diverse factors are involved: the fundamental ones are calcium, calcitriol and phosphorus. Calcium and calcitriol's mechanism of action takes place through its specific receptors, the calcium-sensing receptor (CaR) and the Vitamin D Receptor (VDR). These two factors have an effect not only on its specific receptors, but also they can modify the other receptor in a positive manner, promoting its actions and demonstrating a cooperative effect between the two. Along with calcium and calcitriol, drugs used in the treatment of Chronic Kidney Disease Mineral Bone Disorders (CKD-MBD) also act directly or indirectly on CaR and VDR and therefore are also responsible for the regulation of the parathyroid gland.
Carrillo-López
N
N
Servicio de Metabolismo Oseo y Mineral, Hospital Universitario Central de Asturias, Instituto Reina Sofía de Investigación, REDinREN del ISCIII, Universidad de Oviedo, Oviedo, Spain.
Fernández-Martín
J L
JL
Cannata-Andía
J B
JB
D000535:Aluminum / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D002117:Calcitriol / Q000494:pharmacology / Q000502:physiology*; D002118:Calcium / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D006934:Hypercalcemia / Q000503:physiopathology; D006961:Hyperparathyroidism / Q000503:physiopathology; D006996:Hypocalcemia / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D009924:Organ Culture Techniques; D010280:Parathyroid Glands / Q000502:physiology* / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000502:physiology; D010758:Phosphorus / Q000494:pharmacology / Q000502:physiology; D051381:Rats; D018167:Receptors, Calcitriol / Q000502:physiology*; D044169:Receptors, Calcium-Sensing / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D010281:Parathyroid Hormone; D018167:Receptors, Calcitriol; D044169:Receptors, Calcium-Sensing; D010758:Phosphorus; D000535:Aluminum; D002117:Calcitriol; D002118:Calcium