title: [Gastric mucosa as a target of persistent proinflammatory aggression: pathogenic models of chronic gastritis].
abstract: There are several causes of damage and regeneration of the gastric epithelium (erosive gastropathy) and/or histological inflammation of the gastric mucosa (acute or chronic gastritis). After outlining the usual morphology of chronic gastritis, the authors attempt to identify the biological profile of the main pathogenic models. The first, and by far the most frequent, is the model associated with Helicobacter pylori, which, without crossing the mucosal epithelium, provokes an immune reaction. Although incapable of eradicating this bacterium, this immune reaction contributes to the inflammatory lesion provoked by H. pylori in the mucosa. The second -and much less frequent- model is that causing progressive atrophic gastritis through a humoral and cellular autoimmune mechanism. In third place are a group of models defined by a peculiar cytohistologic pattern of inflammation (granulomatous, lymphocytic or eosinophilic gastritis), suggesting similar pathogenic mechanisms for each of these rare morphological forms of gastritis. Lastly, there is a model barely fitting within the scope of this review, which is that provoking chemical gastropathies (bile reflux, NSAIDs, etc.) with minimal cellular inflammation, i.e., minimal gastritis. To aid understanding of the article, the authors provide a brief outline of the functional histology of the gastric wall and the mechanisms defending its integrity in physiological conditions.
authors.affiliation: Servicio de Aparato Digestivo, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, España. palomasanchezfayos@wanadoo.es
authors.forename: Paloma
authors.initials: P
authors.lastname: Sánchez-Fayos Calabuig
authors.forename: M Jesús
authors.initials: MJ
authors.lastname: Martín Relloso
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Porres Cubero
mesh_terms: D002908:Chronic Disease; D004802:Eosinophilia / Q000276:immunology; D005753:Gastric Mucosa / Q000276:immunology* / Q000473:pathology; D005756:Gastritis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008954:Models, Biological