title: Granular cell tumor of the descending colon treated by endoscopic mucosal resection: a case report and review of the literature.
abstract: Although colorectal granular cell tumors (GCTs) are rare, their incidental finding has increased as the use of diagnostic colonoscopy has become more common. Here we describe the case of a 41-yr-old man with a GCT in the descending colon that was detected after a screening colonoscopy. Endoscopic examination revealed a yellowish submucosal tumor, 13x12 mm in diameter, in the descending colon. Endoscopic mucosal resection (EMR) followed by histological examination revealed that the tumor was composed of plump histiocyte-like cells with an abundant granular eosinophilic cytoplasm and small round nuclei. The tumor cells expressed S-100 protein and stained with periodic acid-Schiff, but were negative for desmin and cytokeratin. The resected tumor was diagnosed as a GCT. Colonoscopists should consider the possibility of GCT in the differential diagnosis of yellowish submucosal tumors of the colon. In such patients, EMR seems to be a feasible and safe approach for diagnosis and treatment.
authors.affiliation: Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, Korea.
authors.forename: Jae Myung
authors.initials: JM
authors.lastname: Cha
authors.forename: Joung Il
authors.initials: JI
authors.lastname: Lee
authors.forename: Kwang Ro
authors.initials: KR
authors.lastname: Joo
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Choe
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Jung
authors.forename: Hyun Phil
authors.initials: HP
authors.lastname: Shin
authors.forename: Sung Jik
authors.initials: SJ
authors.lastname: Lim
mesh_terms: D000328:Adult; D044683:Colon, Descending / Q000473:pathology; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003113:Colonoscopy; D003937:Diagnosis, Differential; D016586:Granular Cell Tumor / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D009418:S100 Proteins