SCAI blocks MAL-evolent effects on cancer cell invasion.
SCAI is a newly discovered protein that reduces cancer cell invasiveness. SCAI inhibits the MAL/SRF transcriptional activator complex that is downstream of Rho GTPase and actin, resulting in reduced expression of beta1-integrins and loss of invasive potential.
Juliano
Rudy
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D000818:Animals; D001665:Binding Sites / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D015536:Down-Regulation / Q000235:genetics; D004742:Enhancer Elements, Genetic / Q000235:genetics; D015870:Gene Expression / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D019012:Integrin beta1 / Q000235:genetics; D051379:Mice; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D015514:Oncogene Proteins, Fusion / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D026362:Serum Response Factor / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; D019012:Integrin beta1; C431575:MRTFA protein, human; C511173:Mrtfa protein, mouse; D015514:Oncogene Proteins, Fusion; C540922:SCAI protein, human; D026362:Serum Response Factor; D015534:Trans-Activators; D014157:Transcription Factors