title: Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population.
abstract: Genetic factor may play a role in the pathogenesis of kidney stone that is found in the northeastern (NE) Thai population. Herein, we report initial evidence suggesting genetic contribution to the disease in this population. We examined 1,034 subjects including 135 patients with kidney stone, 551 family members, and 348 villagers by radiography of kidney-ureter-bladder (KUB) and other methods, and also analyzed stones removed by surgical operations. One hundred and sixteen of 551 family members (21.05%) and 23 of the 348 villagers (6.61%) were affected with kidney stone. The relative risk (lambda(R)) of the disease among family members was 3.18. Calcium stones (whewellite, dahllite, and weddellite) were observed in about 88% of stones analyzed. Our data indicate familial aggregation of kidney stone in this population supporting that genetic factor should play some role in its pathogenesis. Genetic and genomic studies will be conducted to identify the genes associated with the disease.
authors.affiliation: Division of Nephrology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Suchai
authors.initials: S
authors.lastname: Sritippayawan
authors.forename: Sombat
authors.initials: S
authors.lastname: Borvornpadungkitti
authors.forename: Atchara
authors.initials: A
authors.lastname: Paemanee
authors.forename: Chagkrapan
authors.initials: C
authors.lastname: Predanon
authors.forename: Wattanachai
authors.initials: W
authors.lastname: Susaengrat
authors.forename: Duangporn
authors.initials: D
authors.lastname: Chuawattana
authors.forename: Nunghathai
authors.initials: N
authors.lastname: Sawasdee
authors.forename: Sirintra
authors.initials: S
authors.lastname: Nakjang
authors.forename: Suttikarn
authors.initials: S
authors.lastname: Pongtepaditep
authors.forename: Choochai
authors.initials: C
authors.lastname: Nettuwakul
authors.forename: Nanyawan
authors.initials: N
authors.lastname: Rungroj
authors.forename: Somkiat
authors.initials: S
authors.lastname: Vasuvattakul
authors.forename: Prida
authors.initials: P
authors.lastname: Malasit
authors.forename: Pa-thai
authors.initials: PT
authors.lastname: Yenchitsomanus
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D014514:Ureteral Calculi / Q000737:chemistry / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D055815:Young Adult