title: The role of hepatocyte nuclear factor-1beta in the pathogenesis of clear cell carcinoma of the ovary.
abstract: OBJECTIVE
  Clear cell carcinoma (CCC) of the ovary has a number of features distinguishing it from other epithelial ovarian carcinomas (EOC) because of its characteristic histology and biology, frequent concurrence with endometriotic lesion, and highly chemoresistant nature resulting in an extremely poor prognosis. The incidence of CCC has been steadily increasing in Japan. They comprise approximately 20% of all EOC. Understanding the mechanisms of CCC development and elucidating pathogenesis and pathophysiology are intrinsic to prevention and effective therapies for CCC.
  
  
  METHODS
  This article reviews the English language literature for biology, pathogenesis, and pathophysiological studies on endometriosis-associated EOC. Several data are discussed in the context of endometriosis and CCC biology.
  
  
  RESULTS
  Recent studies based on genome-wide expression analysis technology have noted specific expression of hepatocyte nuclear factor-1beta (HNF-1beta) in endometriosis and CCC, suggesting that early differentiation into the clear cell lineage takes place in the endometriosis. The HNF-1beta-dependent pathway of CCC will be discussed, which are providing new insights into regulation of apoptosis and glycogen synthesis and resistance of CCC to anticancer agents.
  
  
  CONCLUSIONS
  This review summarizes recent advances in the HNF-1beta and its target genes; the potential challenges to the understanding of carcinogenesis, pathogenesis, and pathophysiology of CCC; and a possible novel model is proposed.
authors.affiliation: Department of Obstetrics and Gynecology, Nara Medical University, Japan. hirokoba@naramed-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yamada
authors.forename: Seiji
authors.initials: S
authors.lastname: Kanayama
authors.forename: Naoto
authors.initials: N
authors.lastname: Furukawa
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Noguchi
authors.forename: Shoji
authors.initials: S
authors.lastname: Haruta
authors.forename: Shozo
authors.initials: S
authors.lastname: Yoshida
authors.forename: Mariko
authors.initials: M
authors.lastname: Sakata
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sado
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Oi
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D051539:Hepatocyte Nuclear Factor 1-beta / Q000378:metabolism*; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D051539:Hepatocyte Nuclear Factor 1-beta