Linac-based or robotic image-guided stereotactic radiotherapy for isolated lymph node recurrent prostate cancer.
We report on 14 patients treated with linac- or robotic image-guided stereotactic radiotherapy for isolated lymph node recurrence from prostate cancer, up to the mean dose of 30Gy/3 fractions. At the mean follow-up of 18.6months, five patients experienced clinical out-field progression. Toxicity was minimal. Further investigation is warranted in order to identify the patients that benefit most from this treatment modality and to define the optimal association of such local approach with androgen deprivation. Hopefully, effective local therapy might reduce the burden of systemic therapies given to the recurrent/metastatic prostate cancer patients.
Jereczek-Fossa
Barbara A
BA
Department of Radiotherapy, European Institute of Oncology, Milan, Italy. barbara.jereczek@ieo.it
Fariselli
Laura
L
Beltramo
Giancarlo
G
Catalano
Gianpiero
G
Serafini
Flavia
F
Garibaldi
Cristina
C
Cambria
Raffaella
R
Brait
Lorenzo
L
Possanzini
Marco
M
Bianchi
Livia C
LC
Vavassori
Andrea
A
Zerini
Dario
D
Orsi
Franco
F
de Cobelli
Ottavio
O
Orecchia
Roberto
R
D000368:Aged; D015331:Cohort Studies; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000528:radiation effects*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D016634:Radiosurgery / Q000295:instrumentation* / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000295:instrumentation / Q000379:methods; D012189:Retrospective Studies; D018570:Risk Assessment; D012371:Robotics / Q000379:methods*; D016019:Survival Analysis; D016896:Treatment Outcome