title: Synergistic effects of ovine-derived cathelicidins and other antimicrobials against Escherichia coli O157:H7 and Staphylococcus aureus 1056 MRSA.
abstract: Synergistic effects of ovine-derived cathelicidins SMAP29 and OaBac5mini with the antimicrobials polymyxin B, lysozyme, nisin and lactoferrin were investigated against E. coli O157:H7 and S. aureus 1056 MRSA. Lysozyme showed synergy against E. coli O157:H7 with SMAP29, polymyxin B and lactoferrin. Synergy was also found between SMAP29 and lactoferrin against this host. Against S. aureus 1056 MRSA, lysozyme showed synergy with OaBac5mini, polymyxin B and nisin, while synergy was also found between nisin and OaBac5mini and polymyxin B. Other combinations of the antimicrobials were either additive or non-synergistic.
authors.affiliation: Biotechnology Group, School of Engineering and Advanced Technology, Massey University, Private Bag 11-222, Palmerston North, 4442, New Zealand.
authors.forename: Danitsja S
authors.initials: DS
authors.lastname: van der Linden
authors.forename: David
authors.initials: D
authors.lastname: Short
authors.forename: Antje
authors.initials: A
authors.lastname: Dittmann
authors.forename: Pak-Lam
authors.initials: PL
authors.lastname: Yu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001798:Blood Proteins / Q000494:pharmacology*; D054804:Cathelicidins; D004357:Drug Synergism; D019453:Escherichia coli O157 / Q000187:drug effects*; D007781:Lactoferrin / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009113:Muramidase / Q000494:pharmacology*; D009561:Nisin / Q000494:pharmacology*; D011112:Polymyxin B / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D054804:Cathelicidins; C403305:SMAP29 protein, Ovis aries; D009561:Nisin; D009113:Muramidase; D007781:Lactoferrin; D011112:Polymyxin B