title: Impaction bone grafting of the acetabulum at hip revision using a mix of bone chips and a biphasic porous ceramic bone graft substitute.
abstract: OBJECTIVE
  One of the greatest problems of revision hip arthroplasty is dealing with lost bone stock. Good results have been obtained with impaction grafting of allograft bone. However, there have been problems of infection, reproducibility, antigenicity, stability, availability of bone, and cost. Thus, alternatives to allograft have been sought. BoneSave is a biphasic porous ceramic specifically designed for use in impaction grafting. BoneSave is 80% tricalcium phosphate and 20% hydroxyapatite. Previous in vitro and in vivo studies have yielded good results using mixtures of allograft and BoneSave, when compared with allograft alone. This study is the first reported human clinical trial of BoneSave in impaction grafting.
  
  
  METHODS
  We performed a single-institution, multi-surgeon, prospective cohort study. 43 consecutive patients underwent revision hip arthroplasty using BoneSave and allograft to restore missing bone in the acetabulum. 9 patients had cemented acetabular components implanted and 34 uncemented. 10 patients had cemented femoral components implanted and 1 had an uncemented femoral component. 32 patients did not have their femoral component revised.
  
  
  RESULTS
  No patients were lost to follow-up. At a mean follow-up of 24 (11-48) months, there were no re-revisions and there was no implant migration. 1 acetabular component had confluent lucent lines at the implant-graft interface. Complications were rare (1 fracture, 2 dislocations). Patient satisfaction with the procedure was high.
  
  
  CONCLUSIONS
  Short-term results indicate that impaction grafting of BoneSave and allograft is an effective method of dealing with loss of bone stock at revision hip surgery.
authors.affiliation: Department of Academic Orthopaedics, University of Bristol, BIRC Research Labs, Avon Orthopaedic Centre, Bristol. Ashley.blom@nbt.nhs.uk
authors.forename: Ashley W
authors.initials: AW
authors.lastname: Blom
authors.forename: Vikki
authors.initials: V
authors.lastname: Wylde
authors.forename: Christine
authors.initials: C
authors.lastname: Livesey
authors.forename: Michael R
authors.initials: MR
authors.lastname: Whitehouse
authors.forename: Steve
authors.initials: S
authors.lastname: Eastaugh-Waring
authors.forename: Gordon C
authors.initials: GC
authors.lastname: Bannister
authors.forename: Ian D
authors.initials: ID
authors.lastname: Learmonth
mesh_terms: D000077:Acetabulum / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods*; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D002516:Ceramics; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006621:Hip Joint / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D011475:Prosthesis Failure; D011859:Radiography; D012086:Reoperation; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes