The APC/C: a smörgåsbord for proteolysis.
In a recent issue of Molecular Cell, Matyskiela and Morgan (2009) identify the sites on the APC/C that are required for activation and substrate binding, providing insights into how the APC/C works, with implications for the spindle assembly checkpoint that regulates it.
Pines
Jonathon
J
Gurdon Institute, Tennis Court Road, Cambridge, UK.
D020816:Amino Acid Motifs; D064173:Anaphase-Promoting Complex-Cyclosome; D001665:Binding Sites; D064199:Cdc20 Proteins; D064200:Cdh1 Proteins; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000378:metabolism; D004789:Enzyme Activation; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism; D020539:Sequence Analysis, Protein; D013379:Substrate Specificity; D043743:Ubiquitin-Protein Ligase Complexes / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry / Q000378:metabolism / Q000502:physiology
C577495:CDC20 protein, S cerevisiae; D064199:Cdc20 Proteins; D064200:Cdh1 Proteins; D018797:Cell Cycle Proteins; D029701:Saccharomyces cerevisiae Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D044767:Ubiquitin-Protein Ligases