Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii).
A genetically distinct hantavirus, designated Oxbow virus (OXBV), was detected in tissues of an American shrew mole (Neurotrichus gibbsii), captured in Gresham, Oregon, in September 2003. Pairwise analysis of full-length S- and M- and partial L-segment nucleotide and amino acid sequences of OXBV indicated low sequence similarity with rodent-borne hantaviruses. Phylogenetic analyses using maximum-likelihood and Bayesian methods, and host-parasite evolutionary comparisons, showed that OXBV and Asama virus, a hantavirus recently identified from the Japanese shrew mole (Urotrichus talpoides), were related to soricine shrew-borne hantaviruses from North America and Eurasia, respectively, suggesting parallel evolution associated with cross-species transmission.
Kang
Hae Ji
HJ
Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Bennett
Shannon N
SN
Dizney
Laurie
L
Sumibcay
Laarni
L
Arai
Satoru
S
Ruedas
Luis A
LA
Song
Jin-Won
JW
Yanagihara
Richard
R
D000818:Animals; D005075:Biological Evolution; D006476:Orthohantavirus / Q000235:genetics* / Q000502:physiology*; D054884:Host-Pathogen Interactions; D008971:Moles / Q000821:virology*; D009922:Oregon; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification
D012367:RNA, Viral