title: Recurrent Burkholderia infection in patients with chronic granulomatous disease: 11-year experience at a large referral center.
abstract: The epidemiology of Burkholderia infection in persons with chronic granulomatous disease is poorly understood. We used species-specific polymerase chain reaction-based assays and genotyping analyses to identify 32 strains representing 9 Burkholderia species among 50 isolates recovered from 18 patients with chronic granulomatous disease. We found that recurrent pulmonary infection with distinct Burkholderia strains is common in chronic granulomatous disease.
authors.affiliation: Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Greenberg
authors.forename: Joanna B
authors.initials: JB
authors.lastname: Goldberg
authors.forename: Frida
authors.initials: F
authors.lastname: Stock
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Murray
authors.forename: Steven M
authors.initials: SM
authors.lastname: Holland
authors.forename: John J
authors.initials: JJ
authors.lastname: Lipuma
mesh_terms: D019117:Burkholderia / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D019121:Burkholderia Infections / Q000453:epidemiology* / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D005838:Genotype; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D018410:Pneumonia, Bacterial / Q000453:epidemiology* / Q000382:microbiology; D016133:Polymerase Chain Reaction / Q000379:methods; D012008:Recurrence
chemical_list: D004269:DNA, Bacterial