title: Overview of the physical state of proteins within cells.
abstract: Proteins, the end product of gene expression, play a pivotal role in cellular structure and function. To understand how proteins work it is necessary to understand their physical state within the cell. This unit reviews the classification of proteins, how that is related to the hydropathicity of the protein, other factors that affect the heterogeneity of proteins, protein assemblies, methods for altering the solubility of proteins, and limitations of in vitro manipulations of proteins.
authors.affiliation: Wayne State University, Detroit, Michigan, USA.
authors.forename: H R
authors.initials: HR
authors.lastname: Petty
mesh_terms: D020816:Amino Acid Motifs / Q000502:physiology*; D000818:Animals; D001671:Biochemistry / Q000379:methods; D055592:Biophysical Phenomena; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism*; D002477:Cells / Q000737:chemistry / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry; D046912:Multiprotein Complexes / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D055503:Protein Multimerization; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism; D012995:Solubility
chemical_list: D008563:Membrane Lipids; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D011506:Proteins