title: Longitudinal community plasma HIV-1 RNA concentrations and incidence of HIV-1 among injecting drug users: prospective cohort study.
abstract: OBJECTIVE
  To examine the relation between plasma HIV-1 RNA concentrations in the community and HIV incidence among injecting drug users.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Inner city community in Vancouver, Canada.
  
  
  METHODS
  Injecting drug users, with and without HIV, followed up every six months between 1 May 1996 and 30 June 2007.
  
  
  METHODS
  Estimated community plasma HIV-1 RNA in the six months before each HIV negative participant's follow-up visit. Associated HIV incidence.
  
  
  RESULTS
  Among 622 injecting drug users with HIV, 12 435 measurements of plasma HIV-1 RNA were obtained. Among 1429 injecting drug users without HIV, there were 155 HIV seroconversions, resulting in an incidence density of 2.49 (95% confidence interval 2.09 to 2.88) per 100 person years. In a Cox model that adjusted for unsafe sexual behaviours and sharing used syringes, the estimated community plasma HIV-1 RNA concentration remained independently associated with the time to HIV seroconversion (hazard ratio 3.32 (1.82 to 6.08, P<0.001), per log(10) increase). When the follow-up period was limited to observations after 1 January 1988 (when the median plasma HIV RNA concentration was <20 000 copies/ml), the median viral load was no longer statistically associated with HIV incidence (1.70 (0.79 to 3.67, P=0.175), per log(10) increase).
  
  
  CONCLUSIONS
  A longitudinal measure of community plasma HIV-1 RNA concentration was correlated with the community HIV incidence rate and predicted HIV incidence independent of unsafe sexual behaviours and sharing used syringes. If these findings are confirmed, they could help to inform both HIV prevention and treatment interventions.
authors.affiliation: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada. uhri-ew@cfenet.ubc.ca
authors.forename: Evan
authors.initials: E
authors.lastname: Wood
authors.forename: Thomas
authors.initials: T
authors.lastname: Kerr
authors.forename: Brandon D L
authors.initials: BD
authors.lastname: Marshall
authors.forename: Kathy
authors.initials: K
authors.lastname: Li
authors.forename: Ruth
authors.initials: R
authors.lastname: Zhang
authors.forename: Robert S
authors.initials: RS
authors.lastname: Hogg
authors.forename: P Richard
authors.initials: PR
authors.lastname: Harrigan
authors.forename: Julio S G
authors.initials: JS
authors.lastname: Montaner
mesh_terms: D000328:Adult; D001955:British Columbia / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood*; D012044:Regression Analysis; D015819:Substance Abuse, Intravenous / Q000097:blood / Q000453:epidemiology*; D014504:Urban Health
chemical_list: D012367:RNA, Viral