title: Parallel kinetic resolution of D-labelled 2-aryl-propionic and butanoic acids using quasi-enantiomeric combinations of oxazolidin-2-ones.
abstract: The parallel kinetic resolution of racemic 2-aryl-2-deuterio-propionic and butanoic acids using an equimolar combination of quasi-enantiomeric oxazolidin-2-ones is discussed. The levels of diastereoselectivity were high leading to enantiomerically pure D-labeled products in good yield.
authors.affiliation: Department of Chemistry, University of Hull, Hull HU6 7RX, United Kingdom.
authors.forename: Elliot
authors.initials: E
authors.lastname: Coulbeck
authors.forename: Marco
authors.initials: M
authors.lastname: Dingjan
authors.forename: Jason
authors.initials: J
authors.lastname: Eames
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry; D055162:Biocatalysis; D002087:Butyrates / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004867:Equipment Design; D005260:Female; D017022:Flow Injection Analysis; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007774:Lactation / Q000378:metabolism*; D007814:Larva / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D010069:Oxadiazoles / Q000737:chemistry*; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D011422:Propionates / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013549:Sweetening Agents / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D002087:Butyrates; D010069:Oxadiazoles; D023303:Oxazolidinones; D011422:Propionates; D013549:Sweetening Agents