title: Toward prompt gamma spectrometry for monitoring boron distributions during extra corporal treatment of liver metastases by boron neutron capture therapy: a Monte Carlo simulation study.
abstract: A Monte Carlo calculation was carried out for boron neutron capture therapy (BNCT) of extra corporal liver phantom. The present paper describes the basis for a subsequent clinical application of the prompt gamma spectroscopy set-up aimed at in vivo monitoring of boron distribution. MCNP code was used first to validate the homogeneity in thermal neutron field in the liver phantom and simulate the gamma ray detection system (collimator and detector) in the treatment room. The gamma ray of 478 keV emitted by boron in small specific region can be detected and a mathematical formalism was used for the tomography image reconstruction.
authors.affiliation: LPTHIRM, Department of Physics, Saad Dahlab University, Route de Soumaa, Algeria. khelifi@mail.univ-blida.dz
authors.forename: R
authors.initials: R
authors.lastname: Khelifi
authors.forename: V A
authors.initials: VA
authors.lastname: Nievaart
authors.forename: P
authors.initials: P
authors.lastname: Bode
authors.forename: R L
authors.initials: RL
authors.lastname: Moss
authors.forename: G C
authors.initials: GC
authors.lastname: Krijger
mesh_terms: D001895:Boron / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods* / Q000706:statistics & numerical data; D005214:Fast Neutrons / Q000627:therapeutic use; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D015233:Models, Statistical; D009010:Monte Carlo Method; D009426:Netherlands; D019047:Phantoms, Imaging / Q000706:statistics & numerical data; D013051:Spectrometry, Gamma / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D001895:Boron