[Myofibrillar protein tropomyosin and allergic cross-reactivity].
Myofibrillar protein tropomyosin (TM) is a normal physiological protein participating in regulation of muscular contraction. It is widely prevalent among living organisms. This explains cross-reactivity of allergic patients to home dust, sea fish, cockroaches, etc. The presence of similar IgE-binding epitopes in TM of different origin is a key factor in development of cross-reactivity (CR). CR to TM is a general biological phenomenon. We consider modified TM as a basic component in design of allergovaccines of a new generation.
Fedoseeva
V N
VN
Kamysheva
V A
VA
Fedoskova
T G
TG
Nekrasova
O V
OV
D000485:Allergens / Q000008:administration & dosage / Q000009:adverse effects / Q000096:biosynthesis / Q000276:immunology*; D000818:Animals; D001181:Arthropods / Q000276:immunology / Q000378:metabolism*; D003429:Cross Reactions / Q000276:immunology*; D003888:Desensitization, Immunologic; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000517:prevention & control; D009119:Muscle Contraction / Q000502:physiology; D009210:Myofibrils / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014335:Tropomyosin / Q000008:administration & dosage / Q000009:adverse effects / Q000096:biosynthesis / Q000276:immunology*
D000485:Allergens; D011994:Recombinant Proteins; D014335:Tropomyosin