title: Synthesis and characterization of hyperbranched poly(glycidol) modified with pH- and temperature-sensitive groups.
abstract: Hyperbranched poly(glycidol)s with varying degrees of polymerization were modified by reaction with succinic anhydride and isopropylamine to obtain novel pH- and thermosensitive polymers. These polymers exhibited phase transitions in response to decreasing pH and/or increasing temperature, depending on the degree of polymerization and the ratio of succinyl group to N-isopropylamide. It was possible to harvest a bioactive molecule, rose bengal, from solution using the phase transition of thermosensitive hyperbranched poly(glycidol).
authors.affiliation: Department of Applied Chemistry, Osaka Prefecture University, Osaka, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Kojima
authors.forename: Kohei
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Harada
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sakanishi
authors.forename: Kenji
authors.initials: K
authors.lastname: Kono
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D044367:Phase Transition; D011409:Propylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry*; D012395:Rose Bengal / Q000302:isolation & purification; D019802:Succinic Acid / Q000737:chemistry; D013696:Temperature
chemical_list: D000178:Acrylamides; D020099:Coated Materials, Biocompatible; D011409:Propylene Glycols; C502907:polyglycidol; D012395:Rose Bengal; D019802:Succinic Acid; C067295:N-isopropylacrylamide