title: Impact of transmission dynamics on the cost-effectiveness of rotavirus vaccination.
abstract: The objective of this study is to estimate the cost-effectiveness of mass vaccination of US infants with the recently available rotavirus vaccine, RotaTeq. We developed a dynamic transmission model of rotavirus to incorporate herd immunity into cost-effectiveness analysis. Our study indicates that a rotavirus vaccination program would prevent about 90% of rotavirus incidence, mortality, hospitalization and emergency department visits annually. We conclude that a universal rotavirus vaccine program in the US would cost $77.30 per case averted from the health care and give a net saving of $80.75 per case averted from the societal perspectives, respectively. The cost per QALY gained was found to be $104,610 when we considered child with one caregiver, making the rotavirus vaccination program a cost-effective intervention.
authors.affiliation: Department of Epidemiology & Public Health, Yale University School of Medicine, New Haven, CT 06510, USA. eunha.shim@yale.edu
authors.forename: Eunha
authors.initials: E
authors.lastname: Shim
authors.forename: Alison P
authors.initials: AP
authors.lastname: Galvani
mesh_terms: D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D006801:Humans; D015994:Incidence; D007223:Infant; D012400:Rotavirus Infections / Q000191:economics / Q000401:mortality / Q000517:prevention & control* / Q000635:transmission*; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000191:economics* / Q000276:immunology*; D014481:United States; D014611:Vaccination / Q000191:economics*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000191:economics / Q000276:immunology
chemical_list: C492535:RotaTeq; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated