title: Molecular aspects of tumour hypoxia.
abstract: Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its critical role in radio- and chemoresistance and its significance as an adverse prognostic factor have been well established over the last decades. On a cellular level, hypoxia evokes a complex molecular response with a central role for the HIF-1 pathway. The cellular processes under control of HIF-1 contain important prognostic information and comprise potential candidates for directing hypoxia-modifying therapies. This review will provide an overview of the current knowledge on the molecular aspects of tumour hypoxia and the link to clinical practice.
authors.affiliation: Department of Radiation Oncology, 874 Radboud University Nijmegen Medical Centre, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands.
authors.forename: Saskia E
authors.initials: SE
authors.lastname: Rademakers
authors.forename: Paul N
authors.initials: PN
authors.lastname: Span
authors.forename: Johannes H A M
authors.initials: JH
authors.lastname: Kaanders
authors.forename: Fred C G J
authors.initials: FC
authors.lastname: Sweep
authors.forename: Albert J
authors.initials: AJ
authors.lastname: van der Kogel
authors.forename: Johan
authors.initials: J
authors.lastname: Bussink
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy / Q000209:etiology*; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D011379:Prognosis
chemical_list: D051793:Hypoxia-Inducible Factor 1