Cardiogenic shock caused by disulfiram.
Drug intoxication with disulfiram is a rare condition that may lead to severe and potentially fatal cardiovascular manifestations such as cardiogenic shock. We report the case of a female patient with refractory shock after deliberate self-poisoning with disulfiram. Clinical, biochemical and echocardiographic assessment, as well as invasive monitoring confirmed cardiogenic shock associated with this drug. The known mechanisms of action of disulfiram are discussed, and the major collateral effects, especially cardiovascular effects, are described. We underscore the importance of suspecting this diagnosis and of adopting prompt and the most adequate therapeutic approach in this context.
Jerónimo
Ana
A
Serviço de Cuidados Intensivos, Hospital Pedro Hispano, Matosinhos, Portugal. anajeronimo@hotmail.com
Meira
Carla
C
Amaro
Augusta
A
Campello
Glória Cabral
GC
Granja
Cristina
C
D000427:Alcohol Deterrents / Q000506:poisoning*; D004221:Disulfiram / Q000506:poisoning*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000175:diagnosis; D013406:Suicide, Attempted
D000427:Alcohol Deterrents; D004221:Disulfiram