title: Pulmonary myxoma in a sheep.
abstract: Pulmonary myxomas are rare in domestic animals and only two cases have been reported previously in sheep. An 8 x 6 x 4 cm mass was detected in the diaphragmatic lobe of the right lung of a 4-year-old Persian Karakul ewe. The mass was well demarcated, multilobulated, soft in consistency and white in colour. The cut surface exuded a mucoid substance and a distinct capsule was evident. Microscopically, the tumour comprised a hypocellular myxomatous matrix, rich in acid mucopolysaccharides, with scattered spindle-shaped or stellate cells. These cells had uniform, oval-shaped nuclei without visible nucleoli and expressed vimentin and S100 on immunohistochemical examination. These gross, microscopical and immunohistochemical features are characteristics of myxoma.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. oryan@shirazu.ac.ir
authors.forename: A
authors.initials: A
authors.lastname: Oryan
authors.forename: N
authors.initials: N
authors.lastname: Ahmadi
authors.forename: M
authors.initials: M
authors.lastname: Ghane
authors.forename: Y
authors.initials: Y
authors.lastname: Daneshbod
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002467:Cell Nucleus / Q000473:pathology; D037901:Euthanasia, Animal; D017809:Fatal Outcome; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D007150:Immunohistochemistry / Q000662:veterinary; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D009232:Myxoma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D009418:S100 Proteins / Q000032:analysis; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D006025:Glycosaminoglycans; D009418:S100 Proteins; D014746:Vimentin