Salivary biomarkers for the detection of malignant tumors that are remote from the oral cavity.
Proteomic analyses by mass spectrometry are propelling the field of medical diagnostics forward at unprecedented rates because of its ability reliably to identify proteins that are at the femtomole level in concentration. These advancements have also benefited biomarker research to the point where saliva is now recognized as an excellent diagnostic medium for the detection of malignant tumors that are remote from the oral cavity. Saliva is easy to collect and may provide diagnostic information about a variety of cancers. In particular, proof-of-principle has been demonstrated for salivary biomarker research. This article reviews the literature, discusses the theories associated with saliva-based tumor diagnostics, and presents the current research focused on the use of saliva as a diagnostic medium for the detection of cancer.
Bigler
Lenora R
LR
Department of Diagnostic Sciences, University of Texas Dental Branch at Houston, 6516 M.D. Anderson Boulevard, Room 4.133f, Houston, TX 77030, USA.
Streckfus
Charles F
CF
Dubinsky
William P
WP
D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000175:diagnosis*; D002853:Chromatography, Liquid; D005260:Female; D006801:Humans; D013058:Mass Spectrometry; D040081:Protein Array Analysis; D012463:Saliva / Q000737:chemistry*; D015398:Signal Transduction
D014408:Biomarkers, Tumor