Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA termini.
Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA-peptide conjugates that mimic peptidyl-tRNA would be desirable, especially for ribosome structural biology. A flexible solid-phase synthesis strategy now allows efficient access to these highly requested derivatives without restriction on the RNA and peptide sequences.
Moroder
Holger
H
Institute of Organic Chemistry, Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria.
Steger
Jessica
J
Graber
Dagmar
D
Fauster
Katja
K
Trappl
Krista
K
Marquez
Viter
V
Polacek
Norbert
N
Wilson
Daniel N
DN
Micura
Ronald
R
D000595:Amino Acid Sequence; D001483:Base Sequence; D006868:Hydrolysis; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*; D014176:Protein Biosynthesis; D012313:RNA / Q000737:chemistry*; D012346:RNA, Transfer, Amino Acyl / Q000138:chemical synthesis* / Q000737:chemistry
D010455:Peptides; D012346:RNA, Transfer, Amino Acyl; C019037:tRNA, peptidyl-; D012313:RNA