In vitro elution of daptomycin by a synthetic crystallic semihydrate form of calcium sulfate, stimulan.
A synthetic crystallic semihydrate form of calcium sulfate, Stimulan, was evaluated as a biodegradable carrier for the daily in vitro elution of daptomycin. Daptomycin and Stimulan were admixed at a ratio of 95:5. Elution lasted for 28 days. Eluted concentrations peaked on days 1 and 11, when the mean values were 1,320.1 and 949.2 microg/ml, respectively. The lowest eluted concentration was detected on day 28. These results support the application of the system described in experimental models of osteomyelitis.
Kanellakopoulou
Kyriaki
K
4th Department of Internal Medicine, ATTIKON University Hospital, 1 Rimini Street, Athens, Greece.
Panagopoulos
Periklis
P
Giannitsioti
Efthymia
E
Tsaganos
Thomas
T
Carrer
Dionyssia-Pinelopi
DP
Efstathopoulos
Nicolas
N
Giamarellos-Bourboulis
Evangelos J
EJ
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D002133:Calcium Sulfate / Q000737:chemistry*; D017576:Daptomycin / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D017576:Daptomycin; D002133:Calcium Sulfate