title: Neonatal acute myeloid leukemia in an infant whose mother was exposed to diethylstilboestrol in utero.
abstract: We report on an acute myeloid leukemia in a neonate whose mother was exposed to diethylstilboestrol in utero. The newborn presented with leukemia cutis, hemorrhagic skin lesions, hyperleucocytosis and disseminated intravascular coagulation. A bone marrow examination confirmed the diagnosis of acute monocytic leukemia with a t(11;19) MLL-ELL fusion transcript. Chemotherapy was initiated but the child developed a bilateral pulmonary infection that led to fatal respiratory distress. This case shows acute myeloid leukemia and the third pediatric leukemia reported after maternal diethylstilboestrol exposure.
authors.affiliation: Department of Pediatric Hematology-Oncology, St-Luc University Hospital, Université catholique de Louvain, Brussels, Belgium. christophe.chantrain@uclouvain.be
authors.forename: C F
authors.initials: CF
authors.lastname: Chantrain
authors.forename: D
authors.initials: D
authors.lastname: Sauvage
authors.forename: B
authors.initials: B
authors.lastname: Brichard
authors.forename: S
authors.initials: S
authors.lastname: Dupont
authors.forename: H A
authors.initials: HA
authors.lastname: Poirel
authors.forename: G
authors.initials: G
authors.lastname: Ameye
authors.forename: A
authors.initials: A
authors.lastname: De Weer
authors.forename: P
authors.initials: P
authors.lastname: Vandenberghe
authors.forename: T
authors.initials: T
authors.lastname: Detaille
authors.forename: C
authors.initials: C
authors.lastname: Anslot
authors.forename: S Clément
authors.initials: SC
authors.lastname: de Cléty
authors.forename: C
authors.initials: C
authors.lastname: Vermylen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D007247:Infertility, Female / Q000139:chemically induced; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000188:drug therapy / Q000235:genetics; D008297:Male; D009035:Mothers; D051788:Myeloid-Lymphoid Leukemia Protein; D015514:Oncogene Proteins, Fusion; D010375:Pedigree; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D004968:Estrogens, Non-Steroidal; C472772:MLL-ELL fusion protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein; D004054:Diethylstilbestrol