2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships.
Sodium (Na) channels continue to represent an important target for the development of novel anticonvulsants. We have synthesized and evaluated a series of 2,4(5)-diarylimidazoles for inhibition of the human neuronal Na(V)1.2 Na channel isoform. Starting with the unsubstituted lead compound previously published 3, SAR studies were performed introducing substituents with different physico-chemical properties. Lipophilicity (log D(7.4)) and basicity (pK(a)) of the compounds were measured and submitted for QSPR investigations. Some of the active compounds described had IC(50) values that were considerably lower than our lead compound. In particular, the m-CF(3) disubstituted 22 was the most active compound, inhibiting hNa(V)1.2 currents within the nanomolar concentration range (IC(50)=200 nM). In comparison, lamotrigine and phenytoin, two clinically used anticonvulsant drugs known to inhibit Na channels, had IC(50)'s values that were greater than 100 microM.
Fantini
Marco
M
Dipartimento Farmaceutico, Università degli Studi di Parma, Viale G.P. Usberti, 27/A, I-43100 Parma, Italy.
Rivara
Mirko
M
Zuliani
Valentina
V
Kalmar
Christopher L
CL
Vacondio
Federica
F
Silva
Claudia
C
Baheti
Aparna R
AR
Singh
Natasha
N
Merrick
Ellen C
EC
Katari
Ravi S
RS
Cocconcelli
Giuseppe
G
Ghiron
Chiara
C
Patel
Manoj K
MK
D002460:Cell Line; D004594:Electrophysiology; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D026941:Sodium Channel Blockers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015222:Sodium Channels / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
D007093:Imidazoles; D026941:Sodium Channel Blockers; D015222:Sodium Channels