The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon.
METHODS
We investigated the effect of application of fibroblast growth factor (FGF)-2 on the tendon-to-bone remodeling of repaired supraspinatus tendon in rats subjected to bilateral detachment. FGF-2 (100 mg/kg) in a fibrin sealant or sealant alone was applied on the right and left shoulders, respectively. Twelve animals each at 2, 4, and 6 weeks after surgery were sacrificed for histological analysis (n = 5) and biomechanical Q1 testing (n = 7).


RESULTS
Histologically, at 2 weeks, FGF-treated specimens had significantly higher tendon-to-bone insertion maturing scores then untreated specimens (P < .002). At 4 and 6 weeks, the scores of FGF-treated and untreated specimens were similar (P > .05). Biomechanically, FGF-treated specimens were stronger at 2 weeks (P = .001); at 4 and 6 weeks, both specimens exhibited similar strength (P > .05).


CONCLUSIONS
The initial tendon-to-bone remodeling was accelerated by a local application of FGF-2. This may represent a clinically important improvement in rotator cuff repair.
Ide
Junji
J
Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan. ide@kumamoto-u.ac.jp
Kikukawa
Kenshi
K
Hirose
Jun
J
Iyama
Ken-ichi
K
Sakamoto
Hidetoshi
H
Fujimoto
Toru
T
Mizuta
Hiroshi
H
D000208:Acute Disease; D000287:Administration, Topical; D000818:Animals; D001696:Biomechanical Phenomena; D001707:Biopsy, Needle; D016723:Bone Remodeling / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D005500:Follow-Up Studies; D007150:Immunohistochemistry; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology* / Q000601:surgery; D019637:Orthopedic Procedures / Q000379:methods; D011336:Probability; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017006:Rotator Cuff / Q000473:pathology* / Q000601:surgery; D000070636:Rotator Cuff Injuries; D012680:Sensitivity and Specificity; D013708:Tendon Injuries / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D013718:Tensile Strength
D016222:Fibroblast Growth Factor 2