title: [A patient with multiple skin metastases from breast cancer responding to S-1 effectively under treatment with trastuzumab].
abstract: We report a case of a 52-year-old female with multiple skin metastases from breast cancer who responded to S-1. She underwent surgery of her right breast in March 2000 and the left in June 2006. Multiple skin metastases were later detected. As there was no hormone sensitivity, chemotherapy was selected. We started treatment with administration of S-1 at 120mg/day(4 weeks)and trastuzumab. Thoracic CT at the end of the three courses revealed the disappearance of the multiple skin metastases. No major side effects were seen. It was concluded from these findings that S-1 could be safely and effectively administered to advanced breast cancer patients.
authors.affiliation: Department of Breast Center, Nara City Hospital.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Tokugawa
authors.forename: Aya
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Okubo
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Imai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koyama
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008875:Middle Aged; D010094:Oxonic Acid / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D014408:Biomarkers, Tumor; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000068878:Trastuzumab