title: [Hypertension, HIV infection, and highly active antiretroviral therapy].
abstract: The decline in mortality resulting from the use of highly active antiretroviral therapy (HAART) has been accompanied by an increase in metabolic complications that produce accelerated atherosclerosis. Hypertension is one of the most important cardiovascular risk factors. Little is known about the impact of HAART on blood pressure, and it is uncertain whether chronic HIV infection or HAART have a role in the development of hypertension. In this study, the research on the relationships between hypertension and HIV infection published to date is reviewed. Antiretroviral therapy appears to have a modest impact on blood pressure and to be partially mediated by the metabolic changes occurring with this treatment.
authors.affiliation: Unidad VIH, Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, España. jibernardino.hulp@salud.madrid.org
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: Bernardino de la Serna
authors.forename: Francisco Xavier
authors.initials: FX
authors.lastname: Zamora
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Montes
authors.forename: Juan
authors.initials: J
authors.lastname: García-Puig
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Arribas
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000494:pharmacology; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D050197:Atherosclerosis / Q000209:etiology / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D015331:Cohort Studies; D050171:Dyslipidemias / Q000139:chemically induced / Q000150:complications; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D007333:Insulin Resistance; D007674:Kidney Diseases / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced; D008875:Middle Aged; D008954:Models, Biological; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors