title: Photodynamic therapy for the treatment of buccal candidiasis in rats.
abstract: The study objective was to evaluate the effects of photodynamic therapy on buccal candidiasis in rats. After experimental candidiasis had been induced on the tongue dorsum, 72 rats were distributed into four groups according to treatment: treated with laser and methylene blue photosensitizer (L+P+); treated only with laser (L+P-); treated only with photosensitizer (L--P+); not treated with laser or photosensitizer (L-P-). The rats were killed immediately, 1 day, or 5 days after treatment, for microscopic analysis of the tongue dorsum. Observation verified that the photodynamic therapy group (L+P+) exhibited fewer epithelial alterations and a lower chronic inflammatory response than the L-P- group. The group L+P- presented more intense epithelial alterations and chronic inflammatory response than the remaining groups. The L-P+ group showed tissue lesions similar to those of the L-P- group. In conclusion, rats treated with photodynamic therapy developed more discrete candidiasis lesions than did the remaining groups.
authors.affiliation: Department of Biosciences and Oral Diagnosis, School of Dentistry of São José dos Campos, São Paulo State University (UNESP), São Paulo, Brazil. juliana@fosjc.unesp.br
authors.forename: Juliana Campos
authors.initials: JC
authors.lastname: Junqueira
authors.forename: Joyce da Silva
authors.initials: Jda S
authors.lastname: Martins
authors.forename: Raquel Lourdes
authors.initials: RL
authors.lastname: Faria
authors.forename: Carlos Eduardo Dias
authors.initials: CE
authors.lastname: Colombo
authors.forename: Antonio Olavo Cardoso
authors.initials: AO
authors.lastname: Jorge
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification / Q000528:radiation effects; D002180:Candidiasis, Oral / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology / Q000532:radiotherapy; D002610:Cheek; D028022:Low-Level Light Therapy; D008751:Methylene Blue / Q000627:therapeutic use; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014059:Tongue
chemical_list: D017319:Photosensitizing Agents; D008751:Methylene Blue