title: Microvessel density and expression of thrombospondin-1 in non-small cell lung cancer and their correlation with clinicopathological features.
abstract: Microvessel density and thrombospondin-1 (TSP-1) expression were analysed in 42 non-small cell lung cancer (NSCLC) specimens and 40 normal lung tissue specimens using immunohistochemistry. Microvessel density was significantly higher and TSP-1 expression significantly lower in NSCLC tissue compared with normal tissue. Significantly lower levels of TSP-1 expression and higher microvessel densities were found in late-stage NSCLC compared with early-stage NSCLC, and in those with lymph node metastasis compared with those without metastasis. A statistically significant inverse correlation was observed between TSP-1 expression and microvessel density in squamous cell carcinoma but not in adenocarcinoma. These results suggest a close relationship between microvessel density and NSCLC tumour progress, and that a high expression of TSP-1 may play an important role in inhibiting tumour occurrence and development. The lack of correlation between microvessel density and TSP-1 expression in adenocarcinoma suggests that the mechanism of tumour inhibition by TSP-1 varies according to histological type.
authors.affiliation: Department of Thoracic Surgery, The First Hospital, Zhoushan City, China.
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Chen
authors.forename: H B
authors.initials: HB
authors.lastname: Le
authors.forename: Y K
authors.initials: YK
authors.lastname: Zhang
authors.forename: L Y
authors.initials: LY
authors.lastname: Qian
authors.forename: W D
authors.initials: WD
authors.lastname: Li
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D055806:Microvessels / Q000473:pathology*; D019700:Thrombospondin 1 / Q000378:metabolism*
chemical_list: D019700:Thrombospondin 1