Refinement of a quantitative trait locus on equine chromosome 5 responsible for fetlock osteochondrosis in Hanoverian warmblood horses.
In this report, we provide 29 new informative microsatellites distributed over a region of 21 Mb on horse chromosome (ECA) 5 and refine a quantitative trait locus (QTL) for fetlock osteochondrosis dissecans (OCD) to a genome-wide significant interval between 78.03 and 90.23 Mb on ECA5. Genotyping was performed in 211 Hanoverian warmblood horses from 14 paternal half-sib groups. Within this OCD-QTL, collagen type XXIV alpha 1 was identified as a potential functional candidate gene for equine osteochondrosis. This report is a further step towards unravelling the genes that cause equine osteochondrosis.
Lampe
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V
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany.
Dierks
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C
Distl
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O
D000818:Animals; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian; D005534:Foot Diseases / Q000235:genetics / Q000662:veterinary*; D005838:Genotype; D006734:Horse Diseases / Q000235:genetics*; D006736:Horses / Q000235:genetics*; D018895:Microsatellite Repeats; D055034:Osteochondrosis / Q000235:genetics / Q000662:veterinary*; D040641:Quantitative Trait Loci