title: Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect.
abstract: A series of 1-(quinoliloxypropyl)-4-aryl-piperazines has been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypic behaviour in mice. The 8-hydroxyquinoline ether derivative 14 has emerged as an important lead compound showing a potential atypical antipsychotic profile. Employing appropriate physicochemical properties, the similarity of the compounds was assessed with respect to some atypical antipsychotic drugs as clozapine, ketanserine, ziprasidone and risperidone.
authors.affiliation: University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. alka.bali@rediffmail.com
authors.forename: Alka
authors.initials: A
authors.lastname: Bali
authors.forename: Sarika
authors.initials: S
authors.lastname: Malhotra
authors.forename: Himjyoti
authors.initials: H
authors.lastname: Dhir
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Ajay
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015125:Oxyquinoline / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012559:Schizophrenia / Q000139:chemically induced / Q000188:drug therapy; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D015125:Oxyquinoline