HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute human immunodeficiency virus type 1 infection.
NK cells are critical in the early containment of viral infections. Epidemiological and functional studies have shown an important role of NK cells expressing specific killer immunoglobulin-like receptors (KIRs) in the control of human immunodeficiency virus type 1 (HIV-1) infection, but little is known about the mechanisms that determine the expansion of these antiviral NK cell populations during acute HIV-1 infection. Here we demonstrate that NK cells expressing the activating receptor KIR3DS1(+) and, to a lesser extent, the inhibitory receptor KIR3DL1(+) specifically expand in acute HIV-1 infection in the presence of HLA-B Bw480I, the putative HLA class I ligand for KIR3DL1/3DS1. These data demonstrate for the first time the HLA class I subtype-dependent expansion of specific KIR(+) NK cells during an acute viral infection in humans.
Alter
Galit
G
Ragon Institute of MGH, MIT, Boston, Massachusetts, USA. galter@partners.org
Rihn
Suzannah
S
Walter
Katharine
K
Nolting
Anne
A
Martin
Maureen
M
Rosenberg
Eric S
ES
Miller
Jeffrey S
JS
Carrington
Mary
M
Altfeld
Marcus
M
D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000821:virology; D012333:RNA, Messenger / Q000378:metabolism; D054341:Receptors, KIR3DL1 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D054349:Receptors, KIR3DS1 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism
D015235:HLA-B Antigens; D012333:RNA, Messenger; D054341:Receptors, KIR3DL1; D054349:Receptors, KIR3DS1