Common astrocytic programs during brain development, injury and cancer.
In addition to radial glial cells of neurohistogenesis, immature astrocytes with stem-cell-like properties cordon off emerging functional patterns in the developing brain. Astrocytes also can be stem cells during adult neurogenesis, and a proposed potency of injury-associated reactive astrocytes has recently been substantiated. Astrocytic cells might additionally be involved in cancer stem cell-associated gliomagenesis. Thus, there are distinguishing roles for stem-cell-like astrocytes during brain development, in neurogenic niches in the adult, during attempted reactive neurogenesis after brain injury or disease and during brain tumorigenesis.
Silver
Daniel J
DJ
The Evelyn F. and William L. McKnight Brain Institute, The University of Florida, 100 South Newell Drive, P.O. Box 100015, Gainesville, FL 32610-0015, USA.
Steindler
Dennis A
DA
D000328:Adult; D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000473:pathology* / Q000502:physiology*; D001921:Brain / Q000196:embryology* / Q000254:growth & development* / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D002454:Cell Differentiation / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000473:pathology; D055495:Neurogenesis / Q000502:physiology; D013234:Stem Cells / Q000473:pathology* / Q000502:physiology*