Association of diabetes and body mass index with levels of prostate-specific antigen: implications for correction of prostate-specific antigen cutoff values?
BACKGROUND
In a recent study, an inverse association between diabetes and prostate-specific antigen (PSA) levels was observed, and several studies reported lower PSA levels in groups with higher body mass index. However, all of the studies were conducted in populations with intensive PSA screening and the role of diabetes severity, duration, and therapy are yet to be explored.


METHODS
Associations of diabetes duration and treatment, hemoglobin A1c, and BMI with PSA levels were assessed among 778 men ages 50 to 74 years, randomly chosen from the 2000 to 2002 baseline recruitment of a large population-based cohort study in Germany (prevalence of diabetes, 17%), using linear regression analyses.


RESULTS
PSA values were significantly reduced in men with insulin treatment (-39%; P = 0.006) and oral diabetic medication (-24%; P = 0.030), and in men with elevated (6.1-6.9%) and highly (> or =7%) elevated hemoglobin A1c values (-15%, P = 0.004 and -29%, P = 0.003, respectively). PSA reduction was not associated with duration of diabetes. Obesity was possibly associated with a reduction of PSA levels (-14%; P = 0.096).


CONCLUSIONS
Our study suggests that more severe forms of diabetes are associated with lower PSA levels and confirms the magnitude of reduction in PSA levels in diabetic men overall. The observed PSA reduction parallels reported risk reduction of prostate cancer among diabetic men.
Müller
Heiko
H
German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, Bergheimer Strasse 20, D-69115 Heidelberg, Germany. h.mueller@dkfz-heidelberg.de
Raum
Elke
E
Rothenbacher
Dietrich
D
Stegmaier
Christa
C
Brenner
Hermann
H
D000368:Aged; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D005858:Germany; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D012307:Risk Factors
D006442:Glycated Hemoglobin; D017430:Prostate-Specific Antigen