In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube.
A novel murine model of non-typeable Haemophilus influenzae (NTHi) pneumonia was established. A plastic tube was inserted into the trachea 7 days before bacterial inoculation. Numbers of NTHi recovered from the lungs and trachea were determined for 7 days. Histologically, bronchioles and adjacent alveoli in the intubation group were filled with numerous inflammatory cells. The efficacy of sitafloxacin was compared with ciprofloxacin using the new murine pneumonia model. The data suggest that sitafloxacin displays equivalent efficacy to ciprofloxacin against H. influenzae pneumonia. This new murine NTHi pneumonia model appears useful not only for in vivo evaluation of antibiotics but also for analysis of the pathogenesis of H. influenzae pneumonia.
Nakamura
Shigeki
S
Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan.
Yanagihara
Katsunori
K
Araki
Nobuko
N
Morinaga
Yoshitomo
Y
Izumikawa
Koichi
K
Seki
Masafumi
M
Kakeya
Hiroshi
H
Yamamoto
Yoshihiro
Y
Kamihira
Shimeru
S
Kohno
Shigeru
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D055745:Bronchioles / Q000382:microbiology / Q000473:pathology; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D006192:Haemophilus Infections / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology; D006193:Haemophilus influenzae / Q000187:drug effects*; D007442:Intubation, Intratracheal; D008297:Male; D051379:Mice; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000209:etiology; D011650:Pulmonary Alveoli / Q000382:microbiology / Q000473:pathology; D013997:Time Factors; D014132:Trachea / Q000382:microbiology; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; C076246:sitafloxacin