title: A case of finger clubbing associated with nasopharyngeal carcinoma in a young girl, and review of pathophysiology.
abstract: Hypertrophic osteoarthropathy is characterized by clubbing of the digital tips and periosteal reaction of long bones. Most of the cases are associated with malignancy or other conditions such as congenital heart disease, liver cirrhosis, pulmonary fibrosis, biliary atresia and gastrointestinal polyps. Hypertrophic osteoarthropathy associated with malignancy is rare in children. A few cases of hypertrophic osteoarthropathy in children with nasopharyngeal carcinoma have been reported. This is a case of hypertrophic osteoarthropathy associated with nasopharyngeal carcinoma with lung and bone metastasis in a 16 year old girl. In this case, lung metastases progressed after intensive chemotherapy and hypertrophic osteoarthropathy (Clubbing) persisted.
authors.affiliation: Department of Radiation Oncology, The Aga Khan University Hospital, Karachi.
authors.forename: Nasir
authors.initials: N
authors.lastname: Ali
authors.forename: Ahmed Nadeem
authors.initials: AN
authors.lastname: Abbasi
authors.forename: Farook
authors.initials: F
authors.lastname: Karsan
authors.forename: Raheel
authors.initials: R
authors.lastname: Hashmi
authors.forename: Quratul-Ain
authors.initials: QA
authors.lastname: Badar
authors.forename: Asim Jamal
authors.initials: AJ
authors.lastname: Sheikh
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000556:secondary*; D002277:Carcinoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000556:secondary; D018450:Disease Progression; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D009303:Nasopharyngeal Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology*; D014057:Tomography, X-Ray Computed