[A long-term recurrence-free survivor after chemotherapy with 5-FU plus CDDP and surgery for small cell carcinoma of the esophagus].
We report a case of small cell carcinoma of the esophagus(SCEC)treated by chemotherapy with 5-fluorouracil(5- FU)plus cisplatin(CDDP)and operation. A 60-year-old man was seen at the hospital because of a sensation of food sticking in his throat at meals. Gastrointestinal endoscopy revealed a type 2 tumor in the middle portion of the esophagus, which was pathologically diagnosed as small cell carcinoma. With a diagnosis of SCEC, preoperative chemotherapy with 5-FU plus CDDP was given. Primary lesion showed complete response. After chemotherapy, an operation was performed. The tumor had histopathologically disappeared, and the patient has been free of any signs of recurrence, as of 6 years 2 months after the operation. Primary small cell carcinoma of the esophagus is a rare disease with early systemic metastasis, and the prognosis remains poor. In a review of the literature, all patients with SCEC who had survived for 2 years or more had undergone combined therapies including operation, chemotherapy and radiotherapy. This study deals with a long-term surviving patient without any signs of recurrence after excision of the foci followed by chemotherapy.
Aoyama
Toru
T
Department of Surgery, Yokohama Minami Kyosai Hospital.
Saeki
Hiroyuki
H
Fujisawa
Jun
J
Matsukawa
Hiroshi
H
Rino
Yasushi
Y
Masuda
Munetaka
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002945:Cisplatin / Q000627:therapeutic use*; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D004945:Esophagoscopy; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012008:Recurrence; D012074:Remission Induction; D017741:Survivors
D002945:Cisplatin; D005472:Fluorouracil