NO-independent activators of soluble guanylate cyclase: therapeutic potential.
Mathew
Rajamma
R
Section of Pediatric Cardiology, Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York, USA. rajamma_mathew@nymc.edu
D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism; D000975:Antioxidants / Q000494:pharmacology; D051959:ELAV Proteins; D000067780:ELAV-Like Protein 1; D004789:Enzyme Activation; D006162:Guanylate Cyclase / Q000378:metabolism*; D009126:Muscle Relaxation / Q000187:drug effects; D009569:Nitric Oxide / Q000502:physiology; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use; D011725:Pyridines / Q000494:pharmacology / Q000627:therapeutic use; D016601:RNA-Binding Proteins / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D000071756:Soluble Guanylyl Cyclase
C423582:3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine; D000954:Antigens, Surface; D000975:Antioxidants; D051959:ELAV Proteins; D000067780:ELAV-Like Protein 1; C098770:ELAVL1 protein, human; D011720:Pyrazoles; D011725:Pyridines; D016601:RNA-Binding Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase