title: New insights into the pathophysiology of nonalcoholic fatty liver disease.
abstract: The consequences of pathologic adipose tissue accumulation have been described for almost all organs. Nonalcoholic fatty liver disease (NAFLD) is considered the most relevant hepatic manifestation of obesity. There is great interest in the study of NAFLD, and new insights into its pathogenic process have been described. Currently, in addition to insulin resistance, which was considered the hallmark of this disease, endocrine, immunologic, and central nervous system factors are attracting interest as explanatory variables. In this review, new factors associated with the main theories on the pathophysiology of NAFLD are analyzed.
authors.affiliation: Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
authors.forename: Norberto N
authors.initials: NN
authors.lastname: Chávez-Tapia
authors.forename: Misael
authors.initials: M
authors.lastname: Uribe
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Ponciano-Rodríguez
authors.forename: Roberto
authors.initials: R
authors.lastname: Medina-Santillán
authors.forename: Nahum
authors.initials: N
authors.lastname: Méndez-Sánchez
mesh_terms: D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D011379:Prognosis; D012307:Risk Factors; D014630:Vagus Nerve / Q000503:physiopathology*
chemical_list: D005227:Fatty Acids