Paclitaxel-induced ST-segment elevations.
A 51-year-old woman presented with severe chest pain minutes after starting intravenous paclitaxel as a part of the systemic chemotherapy due to ovarian carcinoma. The electrocardiogram (ECG) revealed sinus rhythm with ST-segment elevations in inferior and anterior leads. The ST-segment elevations resolved immediately after sublingual nitroglycerine. Cardiac troponin T and CPK MB levels remained in the normal range at repeat measurements. It was presumed that in spite of standard premedication, paclitaxel had induced acute coronary syndrome with ST-segment elevations in this patient.
Gemici
Gökmen
G
Yeditepe University Hospital, Istanbul, Turkey. kardiyolog@ttnet.net.tr
Cinçin
Altuğ
A
Değertekin
Muzaffer
M
Oktay
Ahmet
A
D054058:Acute Coronary Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D000286:Administration, Sublingual; D000787:Angina Pectoris / Q000139:chemically induced; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D002277:Carcinoma / Q000188:drug therapy*; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced; D052279:Creatine Kinase, MB Form / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D015607:Stents; D016896:Treatment Outcome; D020107:Troponin T / Q000097:blood; D014665:Vasodilator Agents / Q000008:administration & dosage
D000972:Antineoplastic Agents, Phytogenic; D015415:Biomarkers; D020107:Troponin T; D014665:Vasodilator Agents; D052279:Creatine Kinase, MB Form; D005996:Nitroglycerin; D017239:Paclitaxel