title: Association of homozygous SDF-1 3'A genotype with proliferative diabetic retinopathy.
abstract: Stromal cell-derived factor 1 (SDF-1) is involved in the development of experimental proliferative retinopathy. Since little data are available on the genetic predisposition or on biomarkers predicting the development of proliferative retinopathy, we assessed the distribution of the SDF-1 3'A genotype in 130 diabetic patients with retinopathy. In patients with proliferative retinopathy, the frequency of the homozygous SDF-1 3'A genotype was significantly higher than in patients with non-proliferative retinopathy (10.9% of PDR vs. 0 of NPDR, P = 0.01). This association was confirmed when type 2 diabetes patients were analysed separately (10.3% of PDR vs. 0 of NPDR, P = 0.03). The finding that homozygous carriers of the SDF-1 3'A genotype are more frequent in diabetes patients with proliferative retinopathy suggests a possible role of this genotype in the development of sight-threatening diabetic retinopathy.
authors.affiliation: Department of Internal Medicine I and Clinical Chemistry, Ruprecht-Karls University, Heidelberg, Germany. Zdenka.Djuric@med.uni-heidelberg.de
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Djuric
authors.forename: Vahid
authors.initials: V
authors.lastname: Sharei
authors.forename: Gottfried
authors.initials: G
authors.lastname: Rudofsky
authors.forename: Michael
authors.initials: M
authors.lastname: Morcos
authors.forename: Huiqing
authors.initials: H
authors.lastname: Li
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Hammes
authors.forename: Peter P
authors.initials: PP
authors.lastname: Nawroth
authors.forename: Angelika
authors.initials: A
authors.lastname: Bierhaus
authors.forename: Per M
authors.initials: PM
authors.lastname: Humpert
authors.forename: Jost B
authors.initials: JB
authors.lastname: Jonas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001766:Blindness / Q000453:epidemiology / Q000235:genetics; D054377:Chemokine CXCL12 / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000473:pathology; D005260:Female; D005838:Genotype; D006442:Glycated Hemoglobin / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping
chemical_list: D054377:Chemokine CXCL12; D006442:Glycated Hemoglobin