G2A and LPC: regulatory functions in immunity.
The G2A receptor was originally identified by virtue of its transcriptional induction in murine B lymphoid cells in response to oncogenic transformation and treatment with various DNA-damaging agents. While preliminary characterization of cellular responses to G2A overexpression in fibroblastic cell lines suggested that this receptor may negatively regulate cell growth under conditions of proliferative and genotoxic stress, subsequent studies driven by the discovery of lysophosphatidylcholine (LPC) as a regulator of G2A signaling in immunoregulatory cells point to an important role for this receptor in innate and adaptive immunity.
Kabarowski
Janusz H
JH
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170, USA. janusz@uab.edu
D000818:Animals; D017209:Apoptosis; D050197:Atherosclerosis / Q000378:metabolism; D015551:Autoimmunity; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002633:Chemotaxis; D005786:Gene Expression Regulation; D006801:Humans; D007109:Immunity; D007113:Immunity, Innate; D007962:Leukocytes / Q000276:immunology / Q000502:physiology; D008024:Ligands; D008244:Lysophosphatidylcholines / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D018805:Sepsis / Q000276:immunology; D015398:Signal Transduction
D018797:Cell Cycle Proteins; C115270:G2A receptor; D008024:Ligands; D008244:Lysophosphatidylcholines; D043562:Receptors, G-Protein-Coupled