Granular cell tumor of the descending colon treated by endoscopic mucosal resection: a case report and review of the literature.
Although colorectal granular cell tumors (GCTs) are rare, their incidental finding has increased as the use of diagnostic colonoscopy has become more common. Here we describe the case of a 41-yr-old man with a GCT in the descending colon that was detected after a screening colonoscopy. Endoscopic examination revealed a yellowish submucosal tumor, 13x12 mm in diameter, in the descending colon. Endoscopic mucosal resection (EMR) followed by histological examination revealed that the tumor was composed of plump histiocyte-like cells with an abundant granular eosinophilic cytoplasm and small round nuclei. The tumor cells expressed S-100 protein and stained with periodic acid-Schiff, but were negative for desmin and cytokeratin. The resected tumor was diagnosed as a GCT. Colonoscopists should consider the possibility of GCT in the differential diagnosis of yellowish submucosal tumors of the colon. In such patients, EMR seems to be a feasible and safe approach for diagnosis and treatment.
Cha
Jae Myung
JM
Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, Korea.
Lee
Joung Il
JI
Joo
Kwang Ro
KR
Choe
Jae Won
JW
Jung
Sung Won
SW
Shin
Hyun Phil
HP
Lim
Sung Jik
SJ
D000328:Adult; D044683:Colon, Descending / Q000473:pathology; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003113:Colonoscopy; D003937:Diagnosis, Differential; D016586:Granular Cell Tumor / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009418:S100 Proteins / Q000378:metabolism
D009418:S100 Proteins