Network of European studies of genes in growth (NESTEGG).
The network of European studies of genes in growth (NESTEGG) is an international growth genomics project, focusing on the birth size phenotypes of small for gestational age (SGA) and idiopathic short stature. Seven hundred controls and 1,275 cases with their parents have been recruited. Detailed clinical histories and auxological measurements are recorded in a clinical database. Candidate gene studies are being undertaken with the study DNA samples. These genetic data will be used to explore associations with the clinical phenotypes of short stature and SGA birth size, and, in a subset, response to growth hormone (GH) therapy. This article describes the study methodology and reviews the association of the exon 3-deleted genotype of the GH receptor with GH responsiveness in GH-treated children born SGA.
Johnston
Linda B
LB
Barts and the London Queen Mary School of Medicine, London, UK. l.b.johnston@qmul.ac.uk
Ester
Wiestske
W
Caliebe
Janina
J
Molinas
Catherine
C
Wollmann
Hartmut
H
Fryklund
Linda
L
Clark
Adrian J
AJ
Ranke
Michael B
MB
Tauber
Maithe
M
Hokken Koelega
Anita
A
Savage
Martin O
MO
D049628:Body Size / Q000235:genetics*; D005060:Europe; D015894:Genome, Human; D023281:Genomics / Q000639:trends*; D006130:Growth Disorders / Q000188:drug therapy / Q000235:genetics*; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000235:genetics* / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age
D019382:Human Growth Hormone