Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration.
Correct timing of developmental events is crucial for generating a normal organism. During oogenesis in Drosophila melanogaster, migration of border cells occurs in a defined temporal window and requires Jak/Stat and steroid hormone signalling. The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling.
Godt
Dorothea
D
Tepass
Ulrich
U
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology*; D004331:Drosophila melanogaster; D004440:Ecdysone / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D053612:Janus Kinases / Q000378:metabolism; D008954:Models, Biological; D009687:Nuclear Proteins / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology*; D006080:Ovarian Follicle / Q000166:cytology* / Q000502:physiology; D011485:Protein Binding / Q000502:physiology; D011987:Receptors, Steroid / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
D022762:CCAAT-Enhancer-Binding Proteins; D029721:Drosophila Proteins; D009687:Nuclear Proteins; D011987:Receptors, Steroid; D050791:STAT Transcription Factors; C422002:TAI protein, Drosophila; D014157:Transcription Factors; C531978:ab protein, Drosophila; C055469:ecdysone receptor; C077246:slbo protein, Drosophila; D004440:Ecdysone; D053612:Janus Kinases; C085845:hop protein, Drosophila