title: Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part I.
abstract: Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During our ongoing process development work on forodesine HCl several novel compounds were identified as possible impurities in the process. Herein we present the synthesis of three novel compounds (2-4).
authors.affiliation: BioCryst Pharmaceuticals Inc., Birmingham, AL-35244, United States. vkamath@biocryst.com
authors.forename: Vivekanand P
authors.initials: VP
authors.lastname: Kamath
authors.forename: Jie
authors.initials: J
authors.lastname: Xue
authors.forename: Jesus J
authors.initials: JJ
authors.lastname: Juarez-Brambila
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Morris
authors.forename: Rakesh
authors.initials: R
authors.lastname: Ganorkar
authors.forename: Philip E
authors.initials: PE
authors.lastname: Morris
mesh_terms: D049109:Cell Proliferation; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D011684:Purine Nucleosides; D011744:Pyrimidinones; C113101:forodesine; D011683:Purine-Nucleoside Phosphorylase