Gene polymorphisms of renin angiotensin system and serotonin transporter gene in patients with vasovagal syncope.
Objective of this study was to compare the distribution frequencies of gene polymorphisms of renin-angiotensin and serotonin system in patients with positive and negative head- up tilt test (HUT).


METHODS
DNA from 191 patients (mean age 44+ 18 years, 61 men) was collected. HUT was positive in 117 and negative in 74 patients. Following gene polymorphisms were determined by the PCR method: ACE insertion/deletion (I/D ACE), angiotensinogen (AGT) (M 235), angiotensin II receptor (ATR1) (A 1166C) and serotonin transporter (SERT) polymorphism (5HTTLPR).


RESULTS
No significant differences in the distribution of gene polymorphisms between syncopal patients with positive and negative HUT were dectected. Distribution of polymorphisms included: I/D ACE: II 19 vs 20%, ID 55 vs 52%, DD 26 vs 28%. Angiotensinogen gene polymorphism MM 27% vs 30%, MT 48% vs 46%, TT 25% vs 24%. ATR1 polymorphism AA 44 vs 32%, AC50 vs 60%, CC 6 vs 8%, 5HTTLPR serotonin transporter gene polymorphism LL 42 vs 43%, SL 41 vs 39%, SS 17 vs 18%.


CONCLUSIONS
An association between polymorphisms of ACE, AGT, ATR1 and SERT gene, and predisposition to VVS was not proven by the present study (Tab. 2, Ref. 22). Full Text (Free, PDF) www.bmj.sk.
Mudrakova
K
K
Department of Internal Medicine III, University Hospital, Kosice, Slovakia.
Mitro
P
P
Salagovic
J
J
Habalova
V
V
Kirsch
P
P
Tkac
I
I
D000328:Adult; D000808:Angiotensinogen / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic; D044139:Receptor, Angiotensin, Type 2 / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D019462:Syncope, Vasovagal / Q000175:diagnosis / Q000235:genetics*; D018667:Tilt-Table Test
D044139:Receptor, Angiotensin, Type 2; D050486:Serotonin Plasma Membrane Transport Proteins; D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A