title: Adjuvant use of liquid alginate suspension for post-tonsillectomy morbidity: double-blind randomized clinical trial of efficacy.
abstract: OBJECTIVE
  To evaluate the efficacy of liquid alginate suspension in alleviating post-tonsillectomy morbidity in adult patients.
  
  
  METHODS
  A prospective, double-blind, randomized, placebo-controlled study comparing the effect of liquid alginate suspension with placebo was performed on 40 patients who underwent tonsillectomy at Derince State Hospital, Kocaeli, Turkey. The patients were randomly chosen, and each used liquid alginate suspension four times daily or a placebo solution at the same regimen. Tonsillectomy was performed under general anesthesia by cold dissection and suture ligation. Patients were examined at postoperative days 1, 3, 5, and 7 for healing, instructed to note the amount of analgesics used, and asked to mark the visual analog score of throat pain every day for a week.
  
  
  RESULTS
  The study group had statistically significant lower pain scores at day 2 (P = 0.03). Study group required less analgesic than the control group during the study period, but the difference was statistically different only on day 2 (P = 0.003) day. Healing was statistically significant on day 5 (P = 0.03) in the study group.
  
  
  CONCLUSIONS
  Use of the antireflux suspensions in patients undergoing tonsillectomy may be effective in reducing postoperative morbidity in adjunct with classic analgesics.
authors.affiliation: Otorhinolaryngology Department, Namik Kemal University School of Medicine, Tekirdag, Turkey. hmuratyener@gmail.com
authors.forename: Murat
authors.initials: M
authors.lastname: Yener
authors.forename: Erdogan
authors.initials: E
authors.lastname: Gultekin
authors.forename: Ismail
authors.initials: I
authors.lastname: Ozdemir
mesh_terms: D000293:Adolescent; D000328:Adult; D000464:Alginates / Q000627:therapeutic use*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D005260:Female; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D020723:Glucuronic Acid / Q000627:therapeutic use; D006603:Hexuronic Acids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010919:Placebos; D011183:Postoperative Complications / Q000188:drug therapy*; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D013535:Suspensions / Q000627:therapeutic use; D014068:Tonsillectomy; D014069:Tonsillitis / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D010919:Placebos; D013535:Suspensions; D020723:Glucuronic Acid