title: Effect of conventional antihypertensive drugs on hypolipidemic action of garlic in rats.
abstract: The present study was undertaken to determine the possible alteration in hypolipidemic actions of garlic homogenate (GH) in presence of conventional antihypertensive drugs, propranolol (PRO), hydrochlorothiazide (HYD) and captopril (CAP). Albino rats fed with normal fat diet (NFD) or high fat diet (HFD) were treated with GH at three different doses (125, 250 and 500 mg/kg) orally for 30 days or in combination with PRO (10 mg/kg, po), HYD (10 mg/kg, po) and CAP (30 mg/kg, po) during last 7 days of GH treatment. After the treatment, total cholesterol (TC), LDL-cholesterol, triglyceride (TG) and HDL-cholesterol were measured in serum and antiatherogenic index was calculated. The result showed that moderate and high doses of GH possessed potential antiatherosclerotic property that was significantly attenuated by PRO and HYD. However, GH antihyperlipidemic activity was augmented by CAP. It was concluded that administration of PRO and HYD decrease the hypolipidemic effect of GH and administration of GH along with CAP augmented the hypolipidemic effect of GH in rats.
authors.affiliation: Department of Pharmacology, Krupanidhi College of Pharmacy, # 5, Sarjapur Road, Koramangala, Bangalore 560 034, India. basheer_1@rediffmail.com
authors.forename: Syed Mohammed Basheeruddin
authors.initials: SM
authors.lastname: Asdaq
authors.forename: Mohammed Naseeruddin
authors.initials: MN
authors.lastname: Inamdar
authors.forename: Mohammed
authors.initials: M
authors.lastname: Asad
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D004036:Diet, Atherogenic; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005737:Garlic / Q000737:chemistry*; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000959:Antihypertensive Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts