Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis.
Three new antiprotozoan compounds, gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A-C showed antimalarial activity against Plasmodium falciparum with IC(50) values of 0.5-10 microg/mL, whereas gracilioether B (2) also showed antileishmanial activity.
Ueoka
Reiko
R
Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Nakao
Yoichi
Y
Kawatsu
Shizuka
S
Yaegashi
Junko
J
Matsumoto
Yoshitsugu
Y
Matsunaga
Shigeki
S
Furihata
Kazuo
K
van Soest
Rob W M
RW
Fusetani
Nobuhiro
N
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification*; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera
D000962:Antimalarials; D000981:Antiprotozoal Agents; D001688:Biological Products; D005663:Furans; D006575:Heterocyclic Compounds, 3-Ring; C542747:gracilioether A; C542748:gracilioether B; C542749:gracilioether C