title: Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database.
abstract: BACKGROUND
  To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region.
  
  
  METHODS
  The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival.
  
  
  RESULTS
  At baseline, 22% of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001).
  
  
  CONCLUSIONS
  The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI.
authors.affiliation: National Centre in HIV Epidemiology and Clinical Research The University of New South Wales, Sydney, Australia. jzhou@nchecr.unsw.edu.au
authors.forename: Jialun
authors.initials: J
authors.lastname: Zhou
authors.forename: Julian
authors.initials: J
authors.lastname: Elliott
authors.forename: Patrick C K
authors.initials: PC
authors.lastname: Li
authors.forename: Poh Lian
authors.initials: PL
authors.lastname: Lim
authors.forename: Sasisopin
authors.initials: S
authors.lastname: Kiertiburanakul
authors.forename: Nagalingeswaran
authors.initials: N
authors.lastname: Kumarasamy
authors.forename: Tuti Parwati
authors.initials: TP
authors.lastname: Merati
authors.forename: Sanjay
authors.initials: S
authors.lastname: Pujari
authors.forename: Yi-Ming A
authors.initials: YM
authors.lastname: Chen
authors.forename: Praphan
authors.initials: P
authors.lastname: Phanuphak
authors.forename: Saphonn
authors.initials: S
authors.lastname: Vonthanak
authors.forename: Thira
authors.initials: T
authors.lastname: Sirisanthana
authors.forename: Somnuek
authors.initials: S
authors.lastname: Sungkanuparph
authors.forename: Christopher K C
authors.initials: CK
authors.lastname: Lee
authors.forename: Adeeba
authors.initials: A
authors.lastname: Kamarulzaman
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oka
authors.forename: Fujie
authors.initials: F
authors.lastname: Zhang
authors.forename: Goa
authors.initials: G
authors.lastname: Tau
authors.forename: Rossana
authors.initials: R
authors.lastname: Ditangco
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001208:Asia / Q000453:epidemiology; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality
chemical_list: D019380:Anti-HIV Agents