title: Using the Autism-spectrum quotient to discriminate Autism Spectrum Disorder from ADHD in adult patients with and without comorbid Substance Use Disorder.
abstract: It is unknown whether the Autism-spectrum quotient (AQ) can discriminate between Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) with or without comorbid Substance Use Disorder (SUD). ANOVA's were used to analyse the mean AQ (sub)scores of 129 adults with ASD or ADHD. We applied receiver operating characteristic (ROC) computations to assess discriminant power. All but one of the mean AQ (sub)scores were significantly higher for adults with ASD compared to those with ADHD. The SUD status in general was not significantly associated with AQ (sub)scores. On the Social Skills subscale patients with ASD and comorbid SUD showed less impairment than those without SUD. The cut-off score 26 yielded 73% correct classifications. The clinical use of the AQ in differentiating between ASD and ADHD is limited.
authors.affiliation: Department of Developmental Disorders, Dimence Institute of Mental Health, Deventer, The Netherlands. b.sizoo@dimence.nl
authors.forename: Bram B
authors.initials: BB
authors.lastname: Sizoo
authors.forename: Wim
authors.initials: W
authors.lastname: van den Brink
authors.forename: Marielle
authors.initials: M
authors.lastname: Gorissen-van Eenige
authors.forename: Maarten W
authors.initials: MW
authors.lastname: Koeter
authors.forename: Patricia J M
authors.initials: PJ
authors.lastname: van Wijngaarden-Cremers
authors.forename: Rutger Jan
authors.initials: RJ
authors.lastname: van der Gaag
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D001321:Autistic Disorder / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D015897:Comorbidity; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory / Q000706:statistics & numerical data*; D011594:Psychometrics / Q000706:statistics & numerical data; D012016:Reference Values; D015203:Reproducibility of Results; D012919:Social Behavior; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D055815:Young Adult