title: Two-month effects of individualized exercise training with or without caloric restriction on plasma adipocytokine levels in obese female adolescents.
abstract: OBJECTIVE
  To examine if, in young obese patients, an individualized training programme in association with a caloric restriction programme which had an effect on whole-body lipid oxidation, was able to induce changes on plasma adipocytokine concentrations.
  
  
  METHODS
  Twenty-seven obese female adolescents participated in the study. Whole-body lipid oxidation during exercise was assessed by indirect calorimetry during a graded cycle ergometer test. Body mass (BM), body mass index (BMI), percentage of body fat (%BF), insulin homeostasis model assessment (HOMA-IR) and fasting levels of circulating adipocytokines were assessed prior and after a two-month diet programme, individualized training programme targeted at Lipox(max) corresponded to the power at which the highest rate of lipids was oxidized and combined diet/training programme.
  
  
  RESULTS
  The diet/training programme induced both a shift to a higher-power intensity of Lipox(max) (+27.8 + or - 5.1 W; p<0.01) and an increase of lipid oxidation at Lipox(max) (+96.8 + or - 16.2mg/min; p<0.01). The enhancement in lipid oxidation was significantly (p<0.01) correlated with the diet/training-induced improvement in %BF (r = -0.47), HOMA-IR (r = -0.66), leptin (r = -0.41), TNF-alpha (r = -0.48), IL-6 (r = -0.38), adiponectin (r = 0.43) and resistin (r = 0.51).
  
  
  CONCLUSIONS
  This study showed that in obese female adolescents a moderate training protocol targeted at Lipox(max) and combined with a diet programme improved their ability to oxidize lipids during exercise, and that this improvement was associated with changes in plasma adipocytokine concentrations.
authors.affiliation: Laboratoire des adaptations cardiocirculatoires, respiratoires, métaboliques et hormonales à l'exercice musculaire, faculté de médecine Ibn El Jazzar, avenue Mohamed-Karoui, 4002 Sousse, Tunisie. omar_oda@yahoo.fr
authors.forename: O
authors.initials: O
authors.lastname: Ben Ounis
authors.forename: M
authors.initials: M
authors.lastname: Elloumi
authors.forename: G
authors.initials: G
authors.lastname: Lac
authors.forename: E
authors.initials: E
authors.lastname: Makni
authors.forename: E
authors.initials: E
authors.lastname: Van Praagh
authors.forename: H
authors.initials: H
authors.lastname: Zouhal
authors.forename: Z
authors.initials: Z
authors.lastname: Tabka
authors.forename: M
authors.initials: M
authors.lastname: Amri
mesh_terms: D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D031204:Caloric Restriction / Q000379:methods*; D003131:Combined Modality Therapy; D016207:Cytokines / Q000097:blood*; D015444:Exercise; D005260:Female; D006801:Humans; D008055:Lipids / Q000502:physiology; D009765:Obesity / Q000097:blood / Q000534:rehabilitation*; D012885:Skinfold Thickness; D015431:Weight Loss
chemical_list: D054392:Adipokines; D016207:Cytokines; D008055:Lipids