Recurrent Burkholderia infection in patients with chronic granulomatous disease: 11-year experience at a large referral center.
The epidemiology of Burkholderia infection in persons with chronic granulomatous disease is poorly understood. We used species-specific polymerase chain reaction-based assays and genotyping analyses to identify 32 strains representing 9 Burkholderia species among 50 isolates recovered from 18 patients with chronic granulomatous disease. We found that recurrent pulmonary infection with distinct Burkholderia strains is common in chronic granulomatous disease.
Greenberg
David E
DE
Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Goldberg
Joanna B
JB
Stock
Frida
F
Murray
Patrick R
PR
Holland
Steven M
SM
Lipuma
John J
JJ
D019117:Burkholderia / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D019121:Burkholderia Infections / Q000453:epidemiology* / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D005838:Genotype; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D018410:Pneumonia, Bacterial / Q000453:epidemiology* / Q000382:microbiology; D016133:Polymerase Chain Reaction / Q000379:methods; D012008:Recurrence
D004269:DNA, Bacterial