title: Hybrid elastic and discrete-particle approach to biomembrane dynamics with application to the mobility of curved integral membrane proteins.
abstract: We introduce a simulation strategy to consistently couple continuum biomembrane dynamics to the motion of discrete biological macromolecules residing within or on the membrane. The methodology is used to study the diffusion of integral membrane proteins that impart a curvature on the bilayer surrounding them. Such proteins exhibit a substantial reduction in diffusion coefficient relative to "flat" proteins; this effect is explained by elementary hydrodynamic considerations.
authors.affiliation: Department of Chemistry and Biochemistry and Department of Physics, University of California, Santa Barbara, California 93106, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Naji
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Atzberger
authors.forename: Frank L H
authors.initials: FL
authors.lastname: Brown
mesh_terms: D000465:Algorithms; D001703:Biophysics / Q000379:methods*; D003198:Computer Simulation; D004058:Diffusion; D008051:Lipid Bilayers / Q000378:metabolism; D046911:Macromolecular Substances; D008560:Membrane Fluidity; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D015233:Models, Statistical; D012984:Software
chemical_list: D008051:Lipid Bilayers; D046911:Macromolecular Substances; D008565:Membrane Proteins