Two-month effects of individualized exercise training with or without caloric restriction on plasma adipocytokine levels in obese female adolescents.
OBJECTIVE
To examine if, in young obese patients, an individualized training programme in association with a caloric restriction programme which had an effect on whole-body lipid oxidation, was able to induce changes on plasma adipocytokine concentrations.


METHODS
Twenty-seven obese female adolescents participated in the study. Whole-body lipid oxidation during exercise was assessed by indirect calorimetry during a graded cycle ergometer test. Body mass (BM), body mass index (BMI), percentage of body fat (%BF), insulin homeostasis model assessment (HOMA-IR) and fasting levels of circulating adipocytokines were assessed prior and after a two-month diet programme, individualized training programme targeted at Lipox(max) corresponded to the power at which the highest rate of lipids was oxidized and combined diet/training programme.


RESULTS
The diet/training programme induced both a shift to a higher-power intensity of Lipox(max) (+27.8 + or - 5.1 W; p<0.01) and an increase of lipid oxidation at Lipox(max) (+96.8 + or - 16.2mg/min; p<0.01). The enhancement in lipid oxidation was significantly (p<0.01) correlated with the diet/training-induced improvement in %BF (r = -0.47), HOMA-IR (r = -0.66), leptin (r = -0.41), TNF-alpha (r = -0.48), IL-6 (r = -0.38), adiponectin (r = 0.43) and resistin (r = 0.51).


CONCLUSIONS
This study showed that in obese female adolescents a moderate training protocol targeted at Lipox(max) and combined with a diet programme improved their ability to oxidize lipids during exercise, and that this improvement was associated with changes in plasma adipocytokine concentrations.
Ben Ounis
O
O
Laboratoire des adaptations cardiocirculatoires, respiratoires, métaboliques et hormonales à l'exercice musculaire, faculté de médecine Ibn El Jazzar, avenue Mohamed-Karoui, 4002 Sousse, Tunisie. omar_oda@yahoo.fr
Elloumi
M
M
Lac
G
G
Makni
E
E
Van Praagh
E
E
Zouhal
H
H
Tabka
Z
Z
Amri
M
M
D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D031204:Caloric Restriction / Q000379:methods*; D003131:Combined Modality Therapy; D016207:Cytokines / Q000097:blood*; D015444:Exercise; D005260:Female; D006801:Humans; D008055:Lipids / Q000502:physiology; D009765:Obesity / Q000097:blood / Q000534:rehabilitation*; D012885:Skinfold Thickness; D015431:Weight Loss
D054392:Adipokines; D016207:Cytokines; D008055:Lipids