Topiramate and asymptomatic ocular angle narrowing: a prospective pilot study.
OBJECTIVE
To investigate whether subclinical ciliochoroidal effusion and resulting asymptomatic angle narrowing occurs in patients taking topiramate, by ultrasound biomicroscopy (UBM).


METHODS
Chinese patients aged 18-75 years for whom topiramate was indicated were recruited. Examinations including UBM were performed before and 4 weeks after commencement of topiramate.


RESULTS
In this pilot of 20 eyes of 20 patients, there were no statistically significant changes in the angle parameters noted on gonioscopy or UBM, including anterior chamber depth, angle-opening distance at 500 mum, trabecular ciliary process distance, trabecular-iris angle, and scleral thickness.


CONCLUSIONS
Short-term use of topiramate does not induce asymptomatic angle narrowing.
Leung
D Y L
DY
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong. dexleung@alumni.cuhk.net
Leung
H
H
Baig
N
N
Kwan
P
P
Kwong
Y Y Y
YY
Wong
K S
KS
Lam
D S C
DS
D000328:Adult; D000869:Anterior Eye Segment / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D044466:Asian People; D002681:China; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000009:adverse effects*; D010865:Pilot Projects; D011446:Prospective Studies; D000077236:Topiramate; D014792:Visual Acuity / Q000187:drug effects; D055815:Young Adult
D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose