Angiogenic monocytes: another colorful blow to endothelial progenitors.
This Commentary provides perspective on a related article by Sun-Jin Kim and coworkers (Am J Pathol: 172 AJP08-0819), who assess the contribution of bone marrow-derived cells to tumor angiogenesis in a physiologic, non-myeloablative setting and conclude that the actual angiogenic cell type incorporated in the newly formed vessels is actually monocytes/macrophages.
Horrevoets
Anton J G
AJ
VU University Medical Center, Molecular Cell Biology and Immunology, Amsterdam, The Netherlands. aj.horrevoets@vumc.nl
D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D055017:Monocyte-Macrophage Precursor Cells / Q000502:physiology*; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D020286:Pericytes / Q000166:cytology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism
D019408:Platelet Endothelial Cell Adhesion Molecule-1