Perineural meperidine blocks nerve conduction in a dose-related manner: a randomized double-blind study.
BACKGROUND
Meperidine has been shown to exhibit a sensory block in peripheral nerves. However, its motor blockade ability is controversial. The aim of this study was to investigate, electroneurographically, the ability of meperidine to inhibit conduction in both sensory and motor fibres in the ulnar nerve.


METHODS
The study was conducted in a double-blind, placebo-controlled fashion. Eighteen healthy volunteers were randomized into three groups (Saline, meperidine 1% and meperidine 2%). Three millilitre of the study solution was administered to the ulnar nerve perineurally at the level of the wrist by the guidance of a nerve stimulator. Sensory nerve action potential (SNAP) and compound motor action potential (CMAP) amplitudes were recorded. At least a 20% decrease in the initial response amplitude was accepted as a block.


RESULTS
The number of individuals with sensory and motor block with saline, meperidine 1% and meperidine 2% were 0/6, 6/6, 6/6 and 0/6, 5/6, 6/6, respectively (P<0.05). The maximum decrease in the median SNAP and CMAP amplitude values were 4.7% and 8.3% with saline; 38.5% and 46.4% with meperidine 1%; and 100% and 97.8% with meperidine 2%, respectively (P<0.05). Median values for the duration of sensory and motor block with meperidine 1% and meperidine 2% were 45, 52.5 and 30, 32.5 min, respectively.


CONCLUSIONS
Meperidine blocks sensory and motor nerve conduction in a dose-related manner.
Oztürk
E
E
Department of Anaesthesiology and Reanimation, (currently at) American Hospital, Istanbul, Turkey.
Beyazova
M
M
Kaya
K
K
Meray
J
J
Zinnuroglu
M
M
Tarhan
B
B
D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008614:Meperidine / Q000009:adverse effects / Q000494:pharmacology*; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects; D009294:Narcotics / Q000009:adverse effects / Q000494:pharmacology*; D009431:Neural Conduction / Q000187:drug effects*; D011984:Sensory Receptor Cells / Q000187:drug effects; D055815:Young Adult
D009294:Narcotics; D008614:Meperidine