Atrial fibrillation and heart rate independently correlate to microalbuminuria in hypertensive patients.
OBJECTIVE
To investigate the relationship between microalbuminuria (MAU) and atrial fibrillation (AF) and to further evaluate whether the heart rate dependency of MAU in patients without AF is maintained in patients with a history of AF.


RESULTS
The International Survey Evaluating Microalbuminuria Routinely by Cardiologists in patients with Hypertension (I-SEARCH) included 18,900 patients without and 1705 patients with a history of AF suffering from hypertension and other risk factors for cardiovascular disease in 26 countries worldwide from September 2005 to March 2006. Heart rate, blood pressure, urinary albumin excretion, and an estimated glomerular filtration rate were determined among other parameters. The prevalence of MAU was higher at higher heart rate in both patients with and without a history of AF. Prevalence of MAU was about 10% higher in patients with a history of AF (P < 0.001). Male gender, the presence of diabetes mellitus, a higher heart rate, and a higher diastolic blood pressure were independently associated with increased odds for MAU in patients without and with a history of AF.


CONCLUSIONS
The prevalence of MAU in hypertensive patients with cardiovascular risk factors is related to heart rate and significantly higher in patients with a history of AF.
Böhm
Michael
M
Klinik für Innere Medizin III (Kardiologie, Angiologie, Internistische Intensivmedizin), Universität des Saarlandes, Kirrberger Strasse, 66424 Homburg/Saar, Germany. boehm@uks.eu
Thoenes
Martin
M
Neuberger
Hans-Ruprecht
HR
Gräber
Stefan
S
Reil
Jan-Christian
JC
Bramlage
Peter
P
Volpe
Massimo
M
D000368:Aged; D000419:Albuminuria / Q000453:epidemiology / Q000503:physiopathology*; D001281:Atrial Fibrillation / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors