title: Herceptin (trastuzumab) therapy in a twin pregnancy with associated oligohydramnios.
abstract: Herceptin (trastuzumab) is an adjuvant chemotherapy agent used in treatment of certain breast cancers. Limited information is available on the use of herceptin in pregnancy. This case is a twin pregnancy exposed to herceptin until 23 weeks' gestation. One twin had chronic renal failure develop, whereas the other twin did not.
authors.affiliation: Wellington Hospital, Obstetrics and Gynaecology, Wellington, New Zealand. jmab_12@hotmail.com
authors.forename: Jennifer M A
authors.initials: JM
authors.lastname: Beale
authors.forename: Jeremy
authors.initials: J
authors.lastname: Tuohy
authors.forename: Simon J
authors.initials: SJ
authors.lastname: McDowell
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000187:drug effects; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant; D003404:Creatinine / Q000097:blood; D004200:Diseases in Twins / Q000139:chemically induced; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000097:blood / Q000139:chemically induced; D016104:Oligohydramnios / Q000453:epidemiology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D003404:Creatinine; D000068878:Trastuzumab