Intraoperative hypothermia during vascular neurosurgical procedures.
Increasing evidence in animal models and clinical trials for stroke, hypoxic encephalopathy for children, and traumatic brain injury have shown that mild hypothermia may attenuate ischemic damage and improve neurological outcome. However, it is less clear if mild intraoperative hypothermia during vascular neurosurgical procedures results in improved outcomes for patients. This review examines the scientific evidence behind hypothermia as a treatment and discusses factors that may be important for the use of this adjuvant technique, including cooling temperature, duration of hypothermia, and rate of rewarming.
Choi
Raymond
R
Department of Neurosurgery, Stanford University Medical Center, Stanford, California 94305-5327, USA.
Andres
Robert H
RH
Steinberg
Gary K
GK
Guzman
Raphael
R
D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods* / Q000639:trends; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D016343:Monitoring, Intraoperative / Q000379:methods / Q000592:standards; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods*; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D017694:Rewarming / Q000379:methods / Q000592:standards; D018570:Risk Assessment; D013997:Time Factors; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000379:methods*