title: Treatment of vascular and soft-tissue sarcomas in dogs using an alternating protocol of ifosfamide and doxorubicin.
abstract: A retrospective analysis was done to assess the toxicity and efficacy associated with an alternating chemotherapy protocol of ifosfamide (375 mg m(-2)) and doxorubicin (30 mg m(-2)) for adjuvant treatment of 39 dogs with sarcomas. Twelve dogs had various soft-tissue sarcomas and 27 dogs had hemangiosarcoma (HSA). Complete blood counts were evaluated 7 days after the first dose of ifosfamide and doxorubicin. One dog had grade 4 neutropenia (<500 microL(-1)) after treatment with ifosfamide and one dog had grade 3 neutropenia (500-1000 microL(-1)) after treatment with doxorubicin. One dog treated with doxorubicin was hospitalized for 24 h due to vomiting. The median survival time (ST) for the 27 dogs with HSA treated by surgery and with doxorubicin/ifosfamide was 149 days (mean 366 days). Although the protocol of alternating ifosfamide and doxorubicin was well tolerated, it failed to result in a statistically significant improvement in the ST when compared to a historical population of dogs with stage 2 splenic HSA treated by surgery alone.
authors.affiliation: Harrington Oncology Program, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA. sarah.payne@tufts.edu
authors.forename: S E
authors.initials: SE
authors.lastname: Payne
authors.forename: K M
authors.initials: KM
authors.lastname: Rassnick
authors.forename: N C
authors.initials: NC
authors.lastname: Northrup
authors.forename: O
authors.initials: O
authors.lastname: Kristal
authors.forename: J D
authors.initials: JD
authors.lastname: Chretin
authors.forename: S M
authors.initials: SM
authors.lastname: Cotter
authors.forename: P
authors.initials: P
authors.lastname: Kintzer
authors.forename: A E
authors.initials: AE
authors.lastname: Frimberger
authors.forename: K E
authors.initials: KE
authors.lastname: Morrison-Collister
authors.forename: C A
authors.initials: CA
authors.lastname: Wood
authors.forename: A S
authors.initials: AS
authors.lastname: Moore