title: Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer.
abstract: In patients with IBD, chronic colonic inflammation increases the risk of colorectal cancer, perhaps because inflammation predisposes these tissues to genomic instability. Carcinogenesis in the inflamed colon seems to follow a different sequence of genetic alterations than that observed in sporadic cancers in the uninflamed colon. In this Review, we focus on the genetic alterations in colitis-associated colorectal cancer that contribute to the acquisition of the essential hallmarks of cancer, and on how those alterations differ from sporadic colorectal cancers. Our intent is to provide a conceptual basis for categorizing carcinogenetic molecular abnormalities in IBD, and for understanding how cancer-preventive therapies might target reversal of acquired abnormalities in specific biochemical pathways.
authors.affiliation: Division of Gastroenterology, Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA. linda.feagins@va.gov
authors.forename: Linda A
authors.initials: LA
authors.lastname: Feagins
authors.forename: Rhonda F
authors.initials: RF
authors.lastname: Souza
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Spechler
mesh_terms: D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors