Hereditary leukonychia totalis, acanthosis-nigricans-like lesions and hair dysplasia: a new syndrome?
Leukonychia is an ungueal discoloration or dyschromia. The hereditary form is rare. In the observations reported in the literature, leukonychia was total or sub-total, and was sometimes associated to other various symptoms. We report an original observation of hereditary leukonychia totalis in a father and two of his children, associated with acanthosis-nigricans-like lesions and hair dysplasia. These symptoms were also present in eight other members of the same family.
Le Corre
Yannick
Y
University of Angers, University Hospital of Angers, Dermatology Department, 4 Tue Larrey 49933 Angers, Cedex 9, France. lecorre_y@yahoo.fr
Steff
Maud
M
Croue
Anne
A
Filmon
Robert
R
Verret
Jean-Luc
JL
Le Clech
Christian
C
D000052:Acanthosis Nigricans / Q000150:complications* / Q000473:pathology; D002648:Child; D005220:Fathers; D005260:Female; D005799:Genes, Dominant; D006197:Hair / Q000002:abnormalities* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D009260:Nail Diseases / Q000235:genetics*; D009679:Nuclear Family; D010375:Pedigree; D013577:Syndrome