title: Outcomes for 236 patients from a 2-year early intervention in psychosis service.
abstract: OBJECTIVE
  To examine: i) changes in key outcome measures over time in treatment in a representative first-episode psychosis treatment cohort and ii) baseline predictors of service disengagement.
  
  
  METHODS
  Baseline characteristics of 236 patients were examined for associations with outcomes over time using generalized estimating equation models. The data on disengagement were analysed using logistic regression.
  
  
  RESULTS
  After controlling for admission scores, patients showed consistently improved outcomes while in treatment on functional recovery (unemployment, P < 0.01; HoNOS, P < 0.001; the Quality of Life Scale, P < 0.001; GAF, P < 0.05) but not symptomatology (as assessed by the PANSS and substance abuse). The 64 (33%) who disengaged were more likely to be unemployed (P < 0.01) and have higher HoNOS (P < 0.01) and GAF (P < 0.05) scores at baseline.
  
  
  CONCLUSIONS
  This evaluation has shown significant improvements in psychosocial functioning but not psychopathology during treatment at an Early Intervention for Psychosis Service. Despite attempts to retain patients, there is a high rate of treatment discontinuation.
authors.affiliation: Totara House Early Intervention for Psychosis Service, Canterbury District Health Board, Christchurch, New Zealand. mark.turner@cdhb.govt.nz
authors.forename: M A
authors.initials: MA
authors.lastname: Turner
authors.forename: J M
authors.initials: JM
authors.lastname: Boden
authors.forename: C
authors.initials: C
authors.lastname: Smith-Hamel
authors.forename: R T
authors.initials: RT
authors.lastname: Mulder
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006266:Health Education; D006801:Humans; D007360:Intelligence; D007361:Intelligence Tests; D008297:Male; D008605:Mental Health Services / Q000706:statistics & numerical data*; D010348:Patient Care Team; D010353:Patient Education as Topic; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D012017:Referral and Consultation; D012153:Retention, Psychology; D012932:Social Facilitation; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents