title: A new furofuran lignan from Isodon japonicus.
abstract: A new sesamin type furofuran lignan, (-)-sesamin-2,2'-diol (1), along with two known flavonoids (2 and 3) and three phenolic compounds (4-6) were isolated from the aerial parts of Isodon japonicus. The structures of these compounds were determined by analysis of spectroscopic data (1D-, 2D-NMR, HRMS and CD) and by comparison of the data with those of related metabolites.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 361-763, Korea.
authors.forename: Seong Su
authors.initials: SS
authors.lastname: Hong
authors.forename: Chul
authors.initials: C
authors.lastname: Lee
authors.forename: Chang Hee
authors.initials: CH
authors.lastname: Lee
authors.forename: Mieon
authors.initials: M
authors.lastname: Park
authors.forename: Moon Soon
authors.initials: MS
authors.lastname: Lee
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.forename: Heesoon
authors.initials: H
authors.lastname: Lee
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D002853:Chromatography, Liquid; D002942:Circular Dichroism; D037602:Isodon / Q000737:chemistry; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D035261:Plant Components, Aerial; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
chemical_list: D000893:Anti-Inflammatory Agents; D017705:Lignans; D008070:Lipopolysaccharides; D009569:Nitric Oxide