title: Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis.
abstract: Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Umbilical cord derived mesenchymal stem cells are immunosuppressive. We transplanted mesenchymal stem cells in a patient with refractory progressive MS, and the disease course was stabilized after the transplantation. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
authors.affiliation: Department of Immunology and Rheumatology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, P. R. China.
authors.forename: J
authors.initials: J
authors.lastname: Liang
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: B
authors.initials: B
authors.lastname: Hua
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Han
authors.forename: L
authors.initials: L
authors.lastname: Sun
mesh_terms: D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008279:Magnetic Resonance Imaging; D045164:Mesenchymal Stem Cell Transplantation; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D013116:Spinal Cord / Q000473:pathology; D014184:Transplantation, Homologous