title: One-year mortality in coagulase-negative Staphylococcus and Staphylococcus aureus infective endocarditis.
abstract: The aim of this study was to investigate in-hospital mortality and 12-month mortality in patients with coagulase-negative Staphylococcus (CoNS) compared to Staphylococcus aureus (S. aureus) infective endocarditis (IE). We used a prospective cohort study of 66 consecutive CoNS and 170 S. aureus IE patients, collected at 2 tertiary university hospitals in Copenhagen (Denmark) and at 1 tertiary university hospital in Gothenburg (Sweden). Median (range) C-reactive protein at admission was higher in patients with S. aureus IE (150 mg/l (1-521) vs 94 mg/l (6-303); p<0.001), which may suggest a more serous infection. CoNS was associated with prosthetic valve IE (49% vs 24%; p<0.001) and median diagnostic delay was longer in CoNS IE patients (20 d (0-232) vs 9 d (0-132); p<0.001). In-hospital mortality was equally high in both groups but 25% of the CoNS IE patients had died after 1 y compared to 39% of patients with S. aureus IE (p =0.05). In conclusion, CoNS IE was associated with a long diagnostic delay and high in-hospital mortality, whereas post-discharge prognosis was better in this group of patients compared to patients with IE due to S. aureus.
authors.affiliation: Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark. ravera02@geh.regionh.dk
authors.forename: Rasmus V
authors.initials: RV
authors.lastname: Rasmussen
authors.forename: Ulrika
authors.initials: U
authors.lastname: Snygg-Martin
authors.forename: Lars
authors.initials: L
authors.lastname: Olaison
authors.forename: Rune
authors.initials: R
authors.lastname: Andersson
authors.forename: Kristine
authors.initials: K
authors.lastname: Buchholtz
authors.forename: Carsten T
authors.initials: CT
authors.lastname: Larsen
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Hansen
authors.forename: Lars
authors.initials: L
authors.lastname: Køber
authors.forename: Christian
authors.initials: C
authors.lastname: Hassager
authors.forename: Niels E
authors.initials: NE
authors.lastname: Bruun
mesh_terms: D000368:Aged; D003030:Coagulase; D003718:Denmark / Q000453:epidemiology; D004697:Endocarditis, Bacterial / Q000382:microbiology / Q000401:mortality*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000382:microbiology / Q000401:mortality*; D013210:Staphylococcus / Q000302:isolation & purification*; D013211:Staphylococcus aureus / Q000302:isolation & purification; D018709:Statistics, Nonparametric
chemical_list: D003030:Coagulase