title: [Study on bioavailability of Fe-riched wheat varieties using an in vitro digestion/Caco-2 cell model].
abstract: OBJECTIVE
  To select the most promising Fe-riched wheat varieties by studying Fe bioavailability from several wheat variety flours so as to provide scientific evidence for further human trials and nutrition target in wheat breeding.
  
  
  METHODS
  The Fe bioavailability among 10 Fe-riched wheat flours was assessed using an in vitro/Caco-2 cell culture model. Caco-2 cell ferritin formation was measured as an indicator of Fe utilized by human Caco-2 exposing to tested flour digests.
  
  
  RESULTS
  Significant differences were detected in Fe bioavailability among 10 flour varieties, Zhongyou 9507 (from Anyang) and Jingdong 8 with 78% flour yield had the highest Fe bioavailability.
  
  
  CONCLUSIONS
  The two most promising varieties, Zhongyou 9507 (from Anyang) and Jingdong 8 will be further evaluated in human trials to determine their efficacy.
authors.affiliation: West China School of Public Health, Sichuan University, Chengdu 610041, China. jil765@163.com
authors.forename: Ji
authors.initials: J
authors.lastname: Lei
authors.forename: Chengyu
authors.initials: C
authors.lastname: Huang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Mingqiu
authors.initials: M
authors.lastname: Zhang
mesh_terms: D001682:Biological Availability; D018938:Caco-2 Cells; D004063:Digestion; D005293:Ferritins / Q000378:metabolism; D005527:Food, Fortified / Q000032:analysis*; D014644:Genetic Variation; D006801:Humans; D007501:Iron / Q000493:pharmacokinetics*; D014908:Triticum / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
chemical_list: D005293:Ferritins; D007501:Iron