title: Identification of patients at high risk of psychological distress after BRCA1 genetic testing.
abstract: To predict which women might suffer from abnormally high levels of anxiety and depression after receiving a positive genetic BRCA1 test result, series of pregenetic testing and postgenetic testing psychological measurements were performed. Of 3524 women who returned the psychological test sheets before receiving their genetic test result, 111 women were found to carry a BRCA1 mutation. We found that overall, anxiety does not increase in women who receive a positive BRCA1 genetic test result; however, women who experience high levels of anxiety before genetic testing continue to experience high levels of anxiety up to 1 year posttesting. There were differences in cancer-related distress in affected and unaffected women. BRCA1 carriers with a previous diagnosis of cancer had significantly higher levels of cancer-related distress at 1 month posttest than those without cancer. Our findings suggest that healthcare providers should consider including a brief pretest psychological assessment before initiating genetic testing for BRCA1 and BRCA2.
authors.affiliation: Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Ertmański
authors.forename: Kelly
authors.initials: K
authors.lastname: Metcalfe
authors.forename: Janusz
authors.initials: J
authors.lastname: Trempała
authors.forename: Maria Danuta
authors.initials: MD
authors.lastname: Głowacka
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.forename: Jacek
authors.initials: J
authors.lastname: Gronwald
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001007:Anxiety / Q000209:etiology; D019313:BRCA1 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000150:complications / Q000235:genetics / Q000523:psychology*; D003863:Depression / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease / Q000523:psychology*; D005820:Genetic Testing / Q000523:psychology*; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D011446:Prospective Studies; D013315:Stress, Psychological / Q000150:complications / Q000523:psychology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D019313:BRCA1 Protein