title: [Identification of a novel HLA allele DRB1*1462 by sequence-based typing].
abstract: This study was to identify a novel HLA-DRB1 allele in Chinese population by nucleotide sequence ana- lysis. The HLA typing of genes was performed by PCR-SSO and PCR-SSP, the ambiguous novel allele was identified by DNA sequence analysis. The results showed that the sequence of this new allele differed from DRB1*140101 by one nucleotide substitution at position 256 in exon 2 (G- > A), resulting in an amino acid change from Ala to Thr at codon 57. In conclusion, this allele is a novel one, which has been officially given the name DRB1*1462 by the WHO nomenclature committee in January 2006.
authors.affiliation: HLA Laboratory, Beijing Red Cross Blood Center, Beijing 100088, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Cui
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Shan
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: He
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Ni
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Wang
authors.forename: Bo-Tao
authors.initials: BT
authors.lastname: Zhao
authors.forename: Zhi-Yin
authors.initials: ZY
authors.lastname: Gong
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains