Kidney graft loss associated with JC polyomavirus nephropathy.
This is the first case of documented treatment failure of JCV nephritis, despite a reduction of immunosuppressive agents and the use of antiviral therapy. We consistently detected high levels of JCV viremia, which correlated with the progressive deterioration of the graft and caused the final loss of the kidney, suggesting that JCV plays an etiological role in the onset of severe nephropathy in kidney transplant patients.
Rolla
Davide
D
Department of Nephrology, Dialysis and Transplantation, San Martino Hospital, and Section of Microbiology CA Romanzi, DISCMIT, University of Genova, Genova, Italy. davide.rolla@hsanmartino.it
Giacomazzi
Claudio G
CG
Gentile
Raffaella
R
Ravetti
Jean Louis
JL
Cannella
Giuseppe
G
Varnier
Oliviero E
OE
D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007577:JC Virus / Q000235:genetics*; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D027601:Polyomavirus Infections / Q000150:complications* / Q000628:therapy / Q000821:virology; D006435:Renal Dialysis / Q000379:methods; D014412:Tumor Virus Infections / Q000150:complications* / Q000628:therapy / Q000821:virology
D000998:Antiviral Agents; D004279:DNA, Viral