title: 24-hour intraocular pressure and blood pressure levels with latanoprost/timolol fixed combination versus timolol.
abstract: OBJECTIVE
  To evaluate 24-hr intraocular pressure (IOP) and blood pressure (BP) with timolol or latanoprost/timolol fixed combination (LTFC).
  
  
  METHODS
  Patients with primary open-angle glaucoma or ocular hypertension with normal blood pressure were randomized to LTFC, dosed each evening, or timolol dosed twice daily in a cross-over design for 8 weeks and the opposite medicine for 8 weeks. IOP was measured at 02:00, 06:00, 10:00, 14:00, 18:00 and 22:00 hours in the sitting position with Goldmann applanation tonometry and BP monitoring every 30 min while awake and every hour while asleep at the end of each 8-week treatment period.
  
  
  RESULTS
  Twenty-nine patients had a 24-hr baseline IOP of 26.3 +/- 2.5 mmHg, systolic BP (SBP) of 121.4 +/- 12.4 mmHg, diastolic BP (DBP) 72.9 +/- 7.1 mmHg, and ocular perfusion pressure (OPP) of 33.9 +/- 5.7 mmHg. No statistical differences were found between untreated and treated 24-hr SBP, DBP, mean BP (MBP), heart rate, or nocturnal BP dipping status with either medication. LTFC lowered IOP more at each timepoint compared to timolol (difference between treatments 2.7 mmHg, p = 0.0002).
  
  
  CONCLUSIONS
  Neither timolol or evening-dosed LTFC reduced SBP, DBP, MBP, OPP, or increased nocturnal dipping. LTFC was more effective than timolol in decreasing IOP.
authors.affiliation: 1st Department of Medicine, [corrected] AHEPA Hospital, Thessaloniki, Greece.
authors.forename: A G P
authors.initials: AG
authors.lastname: Konstas
authors.forename: M I
authors.initials: MI
authors.lastname: Pikilidou
authors.forename: S
authors.initials: S
authors.lastname: Tsironi
authors.forename: D
authors.initials: D
authors.lastname: Mikropoulos
authors.forename: V P
authors.initials: VP
authors.lastname: Kozobolis
authors.forename: P A
authors.initials: PA
authors.lastname: Sarafidis
authors.forename: A N
authors.initials: AN
authors.lastname: Lasaridis
authors.forename: L A
authors.initials: LA
authors.lastname: Nelson
authors.forename: W C
authors.initials: WC
authors.lastname: Stewart
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005123:Eye / Q000098:blood supply; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects; D013999:Timolol / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D004338:Drug Combinations; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D013999:Timolol