title: Pregnancy outcome after treatment of cervical intraepithelial neoplasia by the loop electrosurgical excision procedure and cold knife conization.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of LEEP and cold-knife conization on the outcome of subsequent pregnancy in a tertiary public hospital.
  
  
  METHODS
  One hundred and ninety-nine patients met the inclusion criteria (age between 18 and 45 years old). Cold-knife conization, LEEP, and both (conization and LEEP) were performed in 102 (51.3%), 95 (47.7%) and two (1%) women, respectively. Average ages were respectively, 33 +/- 7.3; 25 +/- 6.73 and 30 +/- 2.8.
  
  
  RESULTS
  Pregnancies occurred 2.6 and 4.8 years after LEEP and conization, respectively. Miscarriages and preterm pregnancies were more frequent in conization cases versus LEEP, 26% and 5.2%, 23% and 5.5%, respectively.
  
  
  CONCLUSIONS
  If patients express a desire for pregnancy, LEEP should be the procedure of choice.
authors.affiliation: Research Institute of Oncology (IPON), Discipline of Gynecology and Obstetrics, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Michelin
authors.forename: L M
authors.initials: LM
authors.lastname: Merino
authors.forename: C A
authors.initials: CA
authors.lastname: Franco
authors.forename: E F C
authors.initials: EF
authors.lastname: Murta
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D019092:Conization / Q000009:adverse effects*; D004598:Electrosurgery / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D047929:Term Birth; D002583:Uterine Cervical Neoplasms / Q000601:surgery; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000601:surgery