Synchronous incidental gastrointestinal stromal and epithelial malignant tumors.
OBJECTIVE
To investigate the incidence of incidental gastrointestinal stromal tumor (GIST) and its etiopathogenesis.


METHODS
From January 1, 2000 to December 31, 2007, 13804 cases of gastrointestinal epithelial malignant tumor (EMT) and 521 cases of pancreatic adenocarcinoma (PAC) were successfully treated with surgery at the Department of General Surgery and the Department of Thoracic Surgery, West China Hospital, Sichuan University, China. The clinical and pathologic data of 311 cases of primary GIST, including 257 cases with clinical GIST and 54 cases of incidental GIST were analyzed.


RESULTS
Of the 311 patients, 54 had incidental GIST, accounting for 17.4%. Of these tumors, 27 were found in 1.13% patients with esophageal squamous cell carcinoma (ESCC), 22 in 0.53% patients with gastric adenocarcinoma (GAC), 2 in 0.38% patients with PAC, 2 in 0.03% patients with colorectal adenocarcinoma, and 1 in one patient with GAC accompanying ESCC, respectively. Patients with incidental GIST presented symptoms indistinguishable from those with EMT. All incidental GIST lesions were small in size, and the majority had a low mitotic activity while only 1.9% (5/257) of clinical GIST lesions had a high risk.


CONCLUSIONS
Incidental GIST may occur synchronously with other tumors and has a high prevalence in males. Surgery is its best treatment modality.
Liu
Yan-Jun
YJ
Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Yang
Zhou
Z
Hao
Lang-Song
LS
Xia
Lin
L
Jia
Qian-Bin
QB
Wu
Xiao-Ting
XT
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D015897:Comorbidity; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies