title: Relevance of Choukroun's Platelet-Rich Fibrin (PRF) and SMAS flap in primary reconstruction after superficial or subtotal parotidectomy in patients with focal pleiomorphic adenoma: a new technique.
abstract: OBJECTIVE
  Parotidectomy leaves a retromandibular hollow area in proportion with the amount of gland resected. Many surgeons perform primary reconstruction after superficial or subtotal parotidectomy in patients with exo-facial pleiomorphic focal adenoma. Many techniques have been proposed. We present a new technique of filling of the parotidectomy chamber by a second generation leucocyte and platelet concentrate, Platelet-Rich Fibrin (PRF, Choukroun's method).
  
  
  METHODS
  10 patients were included in this preliminary study. Subtotal parotidectomy was performed through classic procedure or lifting procedure. The macroscopic security margin of resection usually allowed performance of a SMAS flap. PRF was prepared following the original Choukroun's method.
  
  
  CONCLUSIONS
  PRF slow resorption after filling of the exeresis cavity, offers a key aesthetic interest. The fibrin matrix of this biomaterial has many angiogenic and healing properties. Synergetic action of the fibrin and the platelets cytokines within PRF may improve revascularization and postoperative resumption of facial nerve function. The membrane formed by the fibrin dense fibrillary network, as well as the SMAS flap, may help to prevent the Frey's syndrome.
  
  
  CONCLUSIONS
  We propose the use of PRF as a filling, healing and interposition material after parotidectomy for benign parotid tumors. Preliminary results are very encouraging. Longer prospective evaluation of this technique is necessary.
authors.affiliation: AP-HP Bicêtre Hospital, Department of Head and Neck Surgery, Université Paris Sud-11, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre, France. jean-baptiste.charrier@bct.aphp.fr
authors.forename: J B
authors.initials: JB
authors.lastname: Charrier
authors.forename: J P
authors.initials: JP
authors.lastname: Monteil
authors.forename: S
authors.initials: S
authors.lastname: Albert
authors.forename: S
authors.initials: S
authors.lastname: Collon
authors.forename: S
authors.initials: S
authors.lastname: Bobin
authors.forename: D M
authors.initials: DM
authors.lastname: Dohan Ehrenfest
mesh_terms: D000236:Adenoma / Q000601:surgery*; D000328:Adult; D001672:Biocompatible Materials; D001792:Blood Platelets; D005337:Fibrin; D006801:Humans; D008875:Middle Aged; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D010307:Parotid Neoplasms / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D013524:Surgical Flaps
chemical_list: D001672:Biocompatible Materials; D005337:Fibrin