Evaluation of wound healing activity of root of Mimosa pudica.
BACKGROUND
Mimosa pudica, commonly known as touch-me-not, is used in folklore medicine in arresting bleeding and in skin diseases.


OBJECTIVE
There was no scientific evidence justifying the use of Mimosa pudica, therefore the present study was aimed at evaluation of wound healing activity of the plant.


METHODS
In the present study the roots of Mimosa pudica were studied for wound healing activity by incorporating the methanolic and the total aqueous extract in simple ointment base B.P. in concentration of 0.5% (w/w), 1% (w/w) and 2% (w/w). Wound healing activity was studied in three types of model in rats viz. excision, incision and estimation of biochemical parameter. In case of the excision wound model wound contraction and period of epithelization was studied while in incision wound model was evaluated by determining tensile strength and hydroxyproline content in the scab.


RESULTS
Treatment of wound with ointment containing 2% (w/w) the methanolic and 2% (w/w) the total aqueous extract exhibited significant (P<0.001) wound healing activity. The methanolic and total aqueous extracts were analyzed for total phenols content equivalent to Gallic acid. The content of total phenols was 11% (w/w) and 17% (w/w) in methanolic and total aqueous extract respectively.


CONCLUSIONS
The methanolic extract exhibited good wound healing activity probably due to phenols constituents.
Kokane
Dnyaneshwar D
DD
Department of Pharmacognosy, SVB's College of Pharmacy, Sonarpada, Kalyan-Shil road, Dombivli (E), Dist-Thane, Maharashtra, Pin code-421204, India.
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Rahul Y
RY
Kale
Mandar B
MB
Nehete
Minakshi N
MN
Mehendale
Prachi C
PC
Gadgoli
Chhaya H
CH
D000279:Administration, Cutaneous; D000470:Alkaloids / Q000032:analysis; D000818:Animals; D005260:Female; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D031298:Mimosa / Q000737:chemistry; D009824:Ointments; D010636:Phenols / Q000032:analysis; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D051381:Rats; D012867:Skin / Q000187:drug effects*; D013634:Tannins / Q000032:analysis; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
D000470:Alkaloids; D009824:Ointments; D010636:Phenols; D010936:Plant Extracts; D013634:Tannins; D006909:Hydroxyproline