title: Growth factors and glucose homeostasis in diabetic rats: effects of exercise training.
abstract: To investigate the alterations of glucose homeostasis and variables of the insulin-like growth factor-1 (IGF-1) growth system in sedentary and trained diabetic (TD) rats, Wistar rats were divided into sedentary control (SC), trained control (TC), sedentary diabetic (SD), and TD groups. Diabetes was induced by Alloxan (35 mg kg(-1) b.w.). Training program consisted of swimming 5 days week(-1), 1 h day(-1), during 8 weeks. Rats were sacrificed and blood was collected for determinations of serum glucose, insulin, growth hormone (GH), IGF-1, and IGF binding protein-3 (IGFBP-3). Muscle and liver were removed to evaluate glycogen content. Cerebellum was extracted to determinate IGF-1 content. Diabetes decreased serum GH, IGF-1, IGFBP-3, liver glycogen, and cerebellum IGF-1 peptide content in baseline condition. Physical training recovered liver glycogen and increased serum and cerebellum IGF-1 peptide in diabetic rats. Physical training induces important metabolic and hormonal alterations that are associated with an improvement in glucose homeostasis and serum and cerebellum IGF-1 concentrations.
authors.affiliation: Department of Physical Education, São Paulo State University (UNESP), Rio Claro-SP, Brazil. ricardojosegome@gmail.com
authors.forename: Ricardo José
authors.initials: RJ
authors.lastname: Gomes
authors.forename: José Alexandre Curiacos de Almeida
authors.initials: JA
authors.lastname: Leme
authors.forename: Leandro Pereira
authors.initials: LP
authors.lastname: de Moura
authors.forename: Michel Barbosa
authors.initials: MB
authors.lastname: de Araújo
authors.forename: Gustavo Puggina
authors.initials: GP
authors.lastname: Rogatto
authors.forename: Rodrigo Ferreira
authors.initials: RF
authors.lastname: de Moura
authors.forename: Eliete
authors.initials: E
authors.lastname: Luciano
authors.forename: Maria Alice Rostom
authors.initials: MA
authors.lastname: de Mello
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002531:Cerebellum / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000628:therapy; D013006:Growth Hormone / Q000032:analysis; D007328:Insulin / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
chemical_list: D001786:Blood Glucose; D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D008112:Liver Glycogen; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone