title: Nucleotide-promoted morphogenesis in amphiphile assemblies: kinetic control of micrometric helix formation.
abstract: Anionic nucleotides adenosine monophosphate or guanosine monophosphate interact with cationic vesicles, exchange with the counteranions of the amphiphiles in situ, and organize themselves at the membrane surfaces. Such organized nucleotides reciprocally transfer their chirality to membranes of nonchiral amphiphiles to induce the formation of right-handed micrometric helices on the time scale of hours. The kinetics of the nucleotide molecular organization and the formation of supramolecular helices was followed. We have shown that helix formation is a kinetic-dependent process that does not primarily result from ion exchange but from conformational reorganization and formation of weak interactions between confined nucleotides.
authors.affiliation: Institut Européen de Chimie et Biologie, UMR 5248 CBMN, CNRS-Université de Bordeaux - ENITAB, 2 rue Robert Escarpit, F-33607 Pessac, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Aimé
authors.forename: Rumi
authors.initials: R
authors.lastname: Tamoto
authors.forename: Takao
authors.initials: T
authors.lastname: Satoh
authors.forename: Axelle
authors.initials: A
authors.lastname: Grelard
authors.forename: Erick J
authors.initials: EJ
authors.lastname: Dufourc
authors.forename: Thierry
authors.initials: T
authors.lastname: Buffeteau
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ihara
authors.forename: Reiko
authors.initials: R
authors.lastname: Oda
mesh_terms: D000838:Anions; D002244:Carbon / Q000737:chemistry; D002412:Cations; D006860:Hydrogen Bonding; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008858:Microscopy, Phase-Contrast / Q000379:methods; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D009690:Nucleic Acid Conformation; D009711:Nucleotides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D013055:Spectrophotometry, Infrared / Q000379:methods; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D013997:Time Factors
chemical_list: D000838:Anions; D002412:Cations; D009711:Nucleotides; D011108:Polymers; D013501:Surface-Active Agents; D002244:Carbon