Cyclic glycopeptidomimetics through a versatile sugar-based scaffold.
Cyclic peptidomimetics are attracting structures to obtain a distinct, bioactive conformation. Even more attractive are sugar-containing cyclic peptidomimetics which present turn structures induced by the pyranose ring when incorporated in cyclic peptides. The use of a new and versatile saccharidic scaffold to achieve sugar-based peptidomimetics is here reported together with the successful synthesis of diastereomerically pure cyclic SAA peptidomimetics 15 and 16.
Altamura
Maria
M
Menarini Ricerche SpA, Firenze, Italy.
Dragoni
Elisa
E
Infantino
Angela Simona
AS
Legnani
Laura
L
Ludbrook
Steve B
SB
Menchi
Gloria
G
Toma
Lucio
L
Nativi
Cristina
C
D002241:Carbohydrates / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D002241:Carbohydrates; D006020:Glycopeptides; D039041:Integrin alpha4beta1; D010456:Peptides, Cyclic