title: Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides.
abstract: This paper describes the synthesis, antiplatelet and theoretical evaluations of 10 N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides (2a-j). These compounds were synthesized, characterized and screened for their in vitro antiplatelet profile against human platelet aggregation using arachidonic acid, adrenaline and ADP as agonists. Among NAH derivatives 2a-j, the compounds 2a, 2c, 2e, 2g and 2h were the most promising molecules with significant antiplatelet activity.
authors.affiliation: Universidade Federal Fluminense, Departamento de Química Orgânica, Outeiro de São João Batista, s/n degrees , Niterói, 24020-141 Rio de Janeiro, Brazil.
authors.forename: Alessandro K
authors.initials: AK
authors.lastname: Jordão
authors.forename: Vitor F
authors.initials: VF
authors.lastname: Ferreira
authors.forename: Emerson S
authors.initials: ES
authors.lastname: Lima
authors.forename: Maria C B V
authors.initials: MC
authors.lastname: de Souza
authors.forename: Eduardo C L
authors.initials: EC
authors.lastname: Carlos
authors.forename: Helena C
authors.initials: HC
authors.lastname: Castro
authors.forename: Reinaldo B
authors.initials: RB
authors.lastname: Geraldo
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Rodrigues
authors.forename: Maria C B
authors.initials: MC
authors.lastname: Almeida
authors.forename: Anna C
authors.initials: AC
authors.lastname: Cunha
mesh_terms: D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D006834:Hydrazines; D010975:Platelet Aggregation Inhibitors; D014230:Triazoles