Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines.
Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with sodium salt of 3-hydroxy-1-(2-naphthyl)prop-2-en-1-one gives pyridin-2-one, pyridin-2(1H)-thione, and pyrazolo[1,5-a]pyrimidine derivatives. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines.
Ahmed
Osama M
OM
Zoology Department, Physiology Division, Faculty of Science, Beni-Suef University, Salah Salim Street, P.O. 62514, Beni-Suef 62514, Egypt. osamamoha@yahoo.com
Mohamed
Mahmoud A
MA
Ahmed
Rasha R
RR
Ahmed
Sayed A
SA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011720:Pyrazoles; D011725:Pyridines; D011743:Pyrimidines; C527752:pyrazolo(1,5-a)pyrimidine