title: A combination chemotherapy protocol with MOPP and CCNU consolidation (Tufts VELCAP-SC) for the treatment of canine lymphoma.
abstract: A chemotherapy protocol using a consolidation phase of alkylating agents was used for treating 94 dogs with lymphoma. Fifty-seven percent of dogs were in stage V, 63% were ill and 38% had T-cell lymphoma. The complete remission (CR) rate was 70% and is comparable to results achieved with previously published chemotherapy protocols. Anorexia predicted the remission; of the 40 dogs without anorexia, 35 (88%) achieved CR whereas of 52 dogs with anorexia, 30 (58%) achieved CR. Median first CR duration was 168 days and 1- and 2-year CR rates were 17.4 and 15.5%, respectively. Platelet count affected length of first CR, with a 53.2% reduced chance of coming out of remission with each log increase in platelet count. Median survival time was 302 days. One and 2-year survival rates were 44 and 13%, respectively. Anorexia and no dose reduction of any drug were independent negative variables. Of 93 dogs with toxicity data, 65 dogs (70%) required a dose reduction. Cyclophosphamide was most commonly reduced with reductions in 31 (38%) of 82 dogs. A dose reduction was significantly more likely in dogs with B-cell lymphoma than in those with T-cell lymphoma.
authors.affiliation: Harrington Oncology Program, Tufts University School of Veterinary Medicine, North Grafton, MA, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Morrison-Collister
authors.forename: K M
authors.initials: KM
authors.lastname: Rassnick
authors.forename: N C
authors.initials: NC
authors.lastname: Northrup
authors.forename: O
authors.initials: O
authors.lastname: Kristal
authors.forename: J D
authors.initials: JD
authors.lastname: Chretin
authors.forename: L E
authors.initials: LE
authors.lastname: Williams
authors.forename: S M
authors.initials: SM
authors.lastname: Cotter
authors.forename: A S
authors.initials: AS
authors.lastname: Moore