Modulation of conduction velocity by nonmyocytes in the low coupling regime.
This paper explores the conditions under which nonmyocytes, when electrically coupled to myocytes, act as a passive load during the depolarization phase. Using theoretical arguments and numerical simulations in a tissue incorporating fibroblasts, the passive load approximation is shown to be accurate at low coupling conductances (< 2 nS). In this case, the effect on conduction velocity can be expressed as a function of the elevation in resting potential and the coupling only.
Jacquemet
Vincent
V
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. vincent.jacquemet@a3.epfl.ch
Henriquez
Craig S
CS
D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D003198:Computer Simulation; D004594:Electrophysiology; D005347:Fibroblasts / Q000502:physiology; D006329:Heart Conduction System / Q000166:cytology*; D008564:Membrane Potentials / Q000502:physiology; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology; D015203:Reproducibility of Results