title: Farnesyl protein transferase inhibitory components of Polygonum multiflorum.
abstract: The methanolic extract of the roots of Polygonum multiflorum (Polygonaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone glycosides, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, KIST, Daejeon, 305-333, Korea.
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Sa Im
authors.initials: SI
authors.lastname: Lee
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Kim
authors.forename: Jae Heon
authors.initials: JH
authors.lastname: Yang
authors.forename: Byeong Suk
authors.initials: BS
authors.lastname: Chae
authors.forename: Jae Hyeok
authors.initials: JH
authors.lastname: Lee
authors.forename: Hee Wook
authors.initials: HW
authors.lastname: Park
authors.forename: Jeong-Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Dae Keun
authors.initials: DK
authors.lastname: Kim
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001681:Biological Assay; D005591:Chemical Fractionation; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D018517:Plant Roots; D028502:Polygonum / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D000880:Anthraquinones; D004791:Enzyme Inhibitors; D006027:Glycosides; D012997:Solvents; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase; D000432:Methanol