Inflammation and NF-kappaB in Alzheimer's disease and diabetes.
Inflammatory processes are a hallmark of many chronic diseases including Alzheimer's disease and diabetes mellitus. Fairly recent statistical evidence indicating that type 2 diabetes increases the risk of developing Alzheimer's disease has led to investigations of the potential common processes that could explain this relation. Here, we review the literature on how inflammation and the inducible nuclear factor NF-kappaB might be involved in both diabetes mellitus and Alzheimer's disease and whether these factors can link both diseases.
Granic
Ivica
I
Department of Molecular Neurobiology, University of Groningen, Haren, The Netherlands.
Dolga
Amalia M
AM
Nijholt
Ingrid M
IM
van Dijk
Gertjan
G
Eisel
Ulrich L M
UL
D000544:Alzheimer Disease / Q000150:complications / Q000201:enzymology*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000201:enzymology*; D006801:Humans; D007249:Inflammation / Q000201:enzymology / Q000209:etiology*; D008954:Models, Biological; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*
D016328:NF-kappa B