IL-21: a new player in the control of isotype switch in Peyer's patches.
Peyer's patches (PP) are lymphoid follicles of the small intestine containing predominantly IgA(+) B cells. In this JLB issue, IL-21 is reported to dampen TGF-beta1-induced IgG2b but not IgA production by mouse B cells, possibly explaining why IgA(+) B cells predominate in PP.
Pistoia
Vito
V
Laboratory of Oncology, G. Gaslini Institute, Largo G. Gaslini, 5, 16147 Genoa, Italy. vitopistoia@ospedale-gaslini.ge.it
Cocco
Claudia
C
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D007070:Immunoglobulin A / Q000096:biosynthesis; D017578:Immunoglobulin Class Switching; D007074:Immunoglobulin G / Q000096:biosynthesis; D007132:Immunoglobulin Isotypes / Q000276:immunology / Q000378:metabolism*; D007378:Interleukins / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D010581:Peyer's Patches / Q000276:immunology / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000276:immunology / Q000378:metabolism; D000098546:Interleukin-21
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007378:Interleukins; D053773:Transforming Growth Factor beta1; D000098546:Interleukin-21