title: Ellipsometric surface plasmon resonance.
abstract: We develop a new multifunctional optical biochip system that integrates an ellipsometer with a surface plasmon resonance (SPR) feature. This newly developed biochip biosensor, which we call ESPR for an ellipsometric SPR, provides us with a system to retrieve detailed information such as the optical properties of immobilized biomolecular monolayers, surface concentration variations of biomedical reactions, and kinetic affinity between biomolecules required for further biotech analysis. Our ESPR can also serve as both a research and development tool and a manufacturing tool for various biomedical applications.
authors.affiliation: National Taiwan University, Institute of Applied Mechanics, Number 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan.
authors.forename: Wei-Liang
authors.initials: WL
authors.lastname: Hsu
authors.forename: Shu-Sheng
authors.initials: SS
authors.lastname: Lee
authors.forename: Chih-Kung
authors.initials: CK
authors.lastname: Lee
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007909:Lenses; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance / Q000295:instrumentation*