Clinical and laboratory versus molecular markers for a correct classification of von Willebrand disease.
von Willebrand disease (VWD) is the most common inherited bleeding disorder. In this perspective article, Drs. Federici and Canciani review how correlating the clinical, laboratory and genetic features of von Willebrand disease has led to improved understanding of its pathophysiology. They show how this has rationalized classification, which in turn can be used to improve treatment of these patients.
Federici
Augusto B
AB
Canciani
Maria T
MT
D001792:Blood Platelets / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D006801:Humans; D008970:Molecular Weight; D009154:Mutation; D055503:Protein Multimerization; D014842:von Willebrand Diseases / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D014841:von Willebrand Factor / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D014841:von Willebrand Factor