title: Metabolic disorders induced by highly active antiretroviral therapy and their relationship with vascular remodeling of the brachial artery in a population of HIV-infected patients.
abstract: Antiretroviral therapy has positively modified the natural history of HIV infection; but this treatment can induce metabolic abnormalities, including dyslipidemia, fat redistribution, high blood pressure, and insulin resistance. The metabolic syndrome, a clustering of the metabolic disorders, is frequently detected among HIV patients, especially those on antiretroviral treatment. All the arteries can modify their diameter in response to a chronic injury. This process, defined vascular remodeling, was demonstrated for the brachial artery. It is well known that the diameter of the brachial artery was correlated with the number of the elements of the metabolic syndrome and was associated with the severity of coronary artery disease. On this basis, we postulate that brachial arterial enlargement may be a process potentially correlated with the metabolic disorders induced by antiretroviral therapy. We tested this hypothesis in a large population of HIV-infected patients in which we measured brachial artery diameter, as an indicator of artery remodeling, by noninvasive, ultrasonographic technique. Our population consisted of 570 patients, with a mean age of 46.3 +/- 7.1 years. All the patients were chronically treated with highly active antiretroviral therapy. Brachial artery diameter was correlated with insulin resistance, evaluated by the homeostasis model assessment of insulin resistance index (r = 0.18, P < .0001). There was a significant linear increase in brachial artery diameter as the number of components of the metabolic syndrome increased: brachial artery diameter for those with 0, 1, 2, 3, or + characteristics was 39.3 +/- 7.2, 41.0 +/- 6.8, 42.0 +/- 7.3, and 43.8 +/- 7.9 mm, respectively (P < .001 for trend). In multivariable logistic regression analysis, brachial artery diameter was independently correlated with the presence of metabolic syndrome. Our results are in line with the hypothesis that, among HIV-infected patients chronically treated with antiretroviral therapy, those with a larger brachial artery diameter are at high risk for metabolic disorders, including a more severe insulin resistance and the presence of metabolic syndrome.
authors.affiliation: Institute of Cardiology, University of Modena and Reggio Emilia. Policlinico Hospital, Modena, Italy. rossi.rosario@unimore.it
authors.forename: Rosario
authors.initials: R
authors.lastname: Rossi
authors.forename: Annachiara
authors.initials: A
authors.lastname: Nuzzo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Guaraldi
authors.forename: Nicola
authors.initials: N
authors.lastname: Squillace
authors.forename: Gabriella
authors.initials: G
authors.lastname: Orlando
authors.forename: Roberto
authors.initials: R
authors.lastname: Esposito
authors.forename: Antonella
authors.initials: A
authors.lastname: Lattanzi
authors.forename: Maria G
authors.initials: MG
authors.lastname: Modena
mesh_terms: D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006678:HIV / Q000254:growth & development*; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D008875:Middle Aged; D015999:Multivariate Analysis; D009389:Neovascularization, Pathologic / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D014463:Ultrasonography; D055815:Young Adult