Lysophosphatidylglycerol inhibits formyl peptide receptorlike-1-stimulated chemotactic migration and IL-1beta production from human phagocytes.
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1beta production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1beta production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.
Shim
Jae Woong
JW
Department of Biochemistry, College of Medicine, Dong-A University, Busan 602-714, Korea.
Jo
Seong Ho
SH
Kim
Sang Doo
SD
Lee
Ha Young
HY
Yun
Jeanho
J
Bae
Yoe Sik
YS
D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D053583:Interleukin-1beta / Q000096:biosynthesis*; D008246:Lysophospholipids / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology; D010586:Phagocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D044042:Receptors, Formyl Peptide / Q000378:metabolism*; D044067:Receptors, Lipoxin / Q000378:metabolism*; D000685:Serum Amyloid A Protein / Q000378:metabolism / Q000494:pharmacology
C105101:FPR2 protein, human; D053583:Interleukin-1beta; D008246:Lysophospholipids; C408903:MMK-1 peptide; D010455:Peptides; D044042:Receptors, Formyl Peptide; D044067:Receptors, Lipoxin; C521404:SAA1 protein, human; D000685:Serum Amyloid A Protein; C026223:lysophosphatidylglycerol