title: Visualizing vesicular dopamine dynamics in Parkinson's disease.
abstract: It has been suggested that dopamine derived from exogenous levodopa may not follow vesicular dynamics in Parkinson's disease (PD). Using a novel PET method based on the sensitivity of [(11)C]-dihydrotetrabenazine (DTBZ) binding to changes in vesicular dopamine levels, we show here that striatal [(11)C]-DTBZ binding decreases after levodopa administration in advanced PD, likely reflecting an increase in vesicular dopamine levels. Endogenous dopamine and exogenously derived dopamine seem to follow the same vesicular dynamics.
authors.affiliation: Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Raúl
authors.initials: R
authors.lastname: de la Fuente-Fernández
authors.forename: Vesna
authors.initials: V
authors.lastname: Sossi
authors.forename: Siobhan
authors.initials: S
authors.lastname: McCormick
authors.forename: Michael
authors.initials: M
authors.lastname: Schulzer
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Ruth
authors.forename: A Jon
authors.initials: AJ
authors.lastname: Stoessl
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001931:Brain Mapping; D002250:Carbon Radioisotopes; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D013747:Tetrabenazine / Q000031:analogs & derivatives
chemical_list: D000978:Antiparkinson Agents; D002250:Carbon Radioisotopes; C032811:dihydrotetrabenazine; D007980:Levodopa; D004298:Dopamine; D013747:Tetrabenazine