title: Host responses to a versatile commensal: PAMPs and PRRs interplay leading to tolerance or infection by Candida albicans.
abstract: The molecular interactions between commensal microorganisms and their host are basically different from those triggered by pathogens since they involve tolerance. When the commensal is genetically equipped to become an opportunistic pathogen, as is the case with Candida albicans, the picture becomes more complex. In this case, the balance between protection and invasion depends on host reactivity to altered microbial expression of ligands interacting with innate immune sensors. Based on experimental evidence obtained with C. albicans, we discuss the different molecular processes involved in the sensing of this important opportunistic human pathogen by a panel of pattern recognition receptors (PRRs) according to the numerous pathogen-associated molecular patterns (PAMPs) that can be exposed at its surface. Beneficial or deleterious immune responses that either maintain a commensal state or favour damage by the yeast result from this dynamic interplay.
authors.affiliation: Inserm U, Pôle Recherche, Lille, France. tjouault@univ-lille2.fr
authors.forename: Thierry
authors.initials: T
authors.lastname: Jouault
authors.forename: Aurore
authors.initials: A
authors.lastname: Sarazin
authors.forename: Maria
authors.initials: M
authors.lastname: Martinez-Esparza
authors.forename: Chantal
authors.initials: C
authors.lastname: Fradin
authors.forename: Boualem
authors.initials: B
authors.lastname: Sendid
authors.forename: Daniel
authors.initials: D
authors.lastname: Poulain
mesh_terms: D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology; D002353:Carrier State / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D051192:Receptors, Pattern Recognition / Q000276:immunology*
chemical_list: D051192:Receptors, Pattern Recognition