SAT in silence.
X chromosome inactivation triggered by Xist RNA can only occur in specific developmental contexts. In this issue of Developmental Cell, Agrelo et al. show that the nuclear matrix protein SATB1 is a critical determinant of Xist responsiveness.
Brockdorff
Neil
N
Department of Biochemistry, University of Oxford, UK. neil.brockdorff@bioch.ox.ac.uk
D000818:Animals; D053595:Embryonic Stem Cells / Q000378:metabolism; D020868:Gene Silencing; D006801:Humans; D008223:Lymphoma / Q000196:embryology / Q000473:pathology; D036961:Matrix Attachment Region Binding Proteins / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000378:metabolism; D049951:X Chromosome Inactivation
D036961:Matrix Attachment Region Binding Proteins; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C469541:Satb1 protein, mouse; C077885:XIST non-coding RNA