title: CD36: a multi-modal target for acute stroke therapy.
abstract: A role for CD36 in the pathogenesis of atherosclerosis, inflammation and lipid metabolism has been well-documented. However, little is known about the role of CD36 in cerebral ischemia. The intent of this review is to develop the concept that CD36, whose functions have been implicated in other pathological events, is a prototypic inflammatory receptor that contributes to the pathogenesis of cerebral ischemia. The importance of CD36 as a treatment target is indicated by the fact that many treatment strategies that are effective in experimental models of stroke exhibit little or no efficacy in clinical trials. The failure of clinical trials may be due to the use of animal models of stroke that do not reflect traditional risk factors for stroke in humans. The discussion will be focused on two risk factors, hyperlipidemia and diabetes, that modulate CD36 responses. Blocking the expression and function of CD36 by pharmacological or genetic means will provide insight not only toward identifying CD36 as a novel molecular target but also for developing effective therapeutic strategies to treat stroke victims. More importantly, coupling clinically relevant conditions with CD36-mediated ischemic injury may provide an appropriate animal model paradigm and develop a scientific understanding that could lead to clinical translational studies involving human subjects.
authors.affiliation: Burke/Cornell Medical Research Institute, White Plains, New York, New York 10605, USA. suc2002@med.cornell.edu
authors.forename: Sunghee
authors.initials: S
authors.lastname: Cho
authors.forename: Eunhee
authors.initials: E
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000818:Animals; D018955:CD36 Antigens / Q000096:biosynthesis / Q000187:drug effects* / Q000378:metabolism*; D004660:Encephalitis / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects; D018919:Neovascularization, Physiologic / Q000187:drug effects; D020521:Stroke / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
chemical_list: D018955:CD36 Antigens