title: Apolipoprotein A-V is a potent modulator of HDL and VLDL components in preadolescent children.
abstract: OBJECTIVE
  Mice lacking apolipoprotein A-V (apoA-V) displayed an increase in serum triglyceride (TG) levels; however, the correlation of apoA-V levels with TG levels in humans is controversial, and the exact mechanism by which apoA-V affects TG levels is unclear. The aim of the present study was to clarify the impact of apoA-V on the lipoprotein subclass profile in preadolescent children, which has not been studied.
  
  
  METHODS
  The study subjects were 178 (89 male, 89 female) 4th grade elementary school children (mean+/-SD: 9.5+/-0.5 years old). ApoA-V levels were determined by an enzyme-linked immunosorbent assay, and the lipid component of each lipoprotein fraction and their particle sizes were measured by HPLC.
  
  
  RESULTS
  Levels of apoA-V showed no gender difference in preadolescent children, and were not affected by anthropometric variables. ApoA-V had a negative association with serum TG levels and TG levels in each lipoprotein fraction, and a positive association with HDL-C. In particular, apoA-V appears to contribute to the increase in cholesterol levels in the larger HDL fraction.
  
  
  CONCLUSIONS
  It was suggested that apoA-V is a potent modulator of HDL and VLDL components in preadolescent children.
authors.affiliation: Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Abe
authors.forename: Tomoo
authors.initials: T
authors.lastname: Okada
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuromori
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Hara
authors.forename: Emiko
authors.initials: E
authors.lastname: Saito
authors.forename: Fujihiko
authors.initials: F
authors.lastname: Iwata
authors.forename: Kensuke
authors.initials: K
authors.lastname: Harada
authors.forename: Hideo
authors.initials: H
authors.lastname: Mugishima
mesh_terms: D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000097:blood*; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D010316:Particle Size; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol