Effective delivery of IgG-antibodies into infected cells via dendritic molecular transporter conjugate IgGMT.
IgG antibody-transporter conjugates enable intracellular uptake of biologically active IgG antibodies that inhibit viral mediated syncytia formation in respiratory syncytial virus green fluorescent protein (RSV-GFP) infected human epithelial cells (HEp-2).
Hamilton
Sharon K
SK
Department of Chemistry, 7619 Stevenson Center, Vanderbilt University, Nashville, TN, USA.
Ikizler
Mine R
MR
Wallen
Christian
C
Wright
Peter F
PF
Harth
Eva
E
D000911:Antibodies, Monoclonal; D002352:Carrier Proteins; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000737:chemistry; D049452:Green Fluorescent Proteins / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008958:Models, Molecular; D010865:Pilot Projects; D021381:Protein Transport; D018357:Respiratory Syncytial Virus Infections / Q000628:therapy; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology; D013997:Time Factors; D014764:Viral Proteins
D000911:Antibodies, Monoclonal; D002352:Carrier Proteins; D050091:Dendrimers; D007074:Immunoglobulin G; D014764:Viral Proteins; D049452:Green Fluorescent Proteins