title: Maternal and fetal near-term sheep cytokine responses to carbon dioxide pneumoperitoneum.
abstract: It is known that carbon dioxide (CO2) pneumoperitoneum induces fetal acidosis in pregnant ewes. Our aim was to determine changes of the levels of maternal and fetal cytokines interleukin-6, interleukin-8, and tumor necrosis factor alpha after CO2 pneumoperitoneum in pregnant ewes. Eight ewes with singleton pregnancies of 120 to 140 days gestation were anesthetized and intubated. Insufflation produced modest but significant maternal arterial hypercapnia (an increase of 10.7 mm Hg; P<0.001) and acidosis (a decrease in mean pH of 0.1.04; P=0.0005). Fetal pCO2 was increased by 15.3 mm Hg on average and pH was decreased by 0.11 U on average immediately after desufflation (both P<0.001). No significant difference was observed in the concentration of cytokine in the maternal or fetal blood samples. These results suggest that respiratory acidosis does not lead to the elevation of cytokines in pregnant ewes and fetuses, which may contribute to premature labor.
authors.affiliation: Department of General Surgery, Mersin City Hospital, Mersin, Turkey. atekin@imchospital.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tekin
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Evruke
authors.forename: Okan
authors.initials: O
authors.lastname: Deveci
mesh_terms: D000142:Acidosis, Respiratory / Q000209:etiology* / Q000503:physiopathology; D000704:Analysis of Variance; D000818:Animals; D002245:Carbon Dioxide / Q000633:toxicity*; D016207:Cytokines / Q000276:immunology*; D005260:Female; D005315:Fetal Diseases / Q000209:etiology* / Q000503:physiopathology; D005333:Fetus / Q000276:immunology*; D006935:Hypercapnia / Q000209:etiology*; D015850:Interleukin-6; D016209:Interleukin-8; D008431:Maternal-Fetal Exchange; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects*; D011247:Pregnancy; D012307:Risk Factors; D012756:Sheep; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D002245:Carbon Dioxide