[Effects of curcumin on malondialdehyde and c-fos protein in hypoxia ischemia brain tissue in rats].
OBJECTIVE
To explore the effects of curcumin on the content of malondialdehyde (MDA) and the expression level of c-fos protein following hypoxia ischemia brain damage (HIBD) in rats.


METHODS
Sprague-Dauley (SD) rats were randomly divided into four groups as the following: sham group, hypoxia ischemia brain damage group, curcumin group and solvent control group. The content of MDA in the brain was measured by colorimetry. The expression level of c-fos protein in the cortex tissue was detected by immunohistochemistry. Morphologic and structural changes of neuron cells of the cortex were observed by electron microscopy.


RESULTS
The content of MDA was clearly lower in curcumin group than that in the other groups at the same time after HIBD. The expression level of c-fos protein was higher in the curcumin group than that in the other groups (P<0.05). Electron microscopy showed that the morphologic and structural changes of neuron cells of cortex in the curcumin group were reduced.


CONCLUSIONS
Curcumin could significantly decrease the content of MDA, increase the expression level of c-fos protein and reduce the damage of the neuron cells.
Zheng
Yuan-yuan
YY
Department of Forensic Medicine, Wenzhou Medical College, Wenzhou 325035, China. yyzdxno@163.com
Yu
Lin-sheng
LS
Zhang
Yi-gu
YG
Ye
Guang-hua
GH
Yi
Ji-pu
JP
D000818:Animals; D003474:Curcumin / Q000494:pharmacology*; D049429:Forensic Pathology; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D018696:Neuroprotective Agents; D016760:Proto-Oncogene Proteins c-fos; D008315:Malondialdehyde; D003474:Curcumin