title: One-pot three-component Mannich-type reactions using sulfamic acid catalyst under ultrasound irradiation.
abstract: Sulfamic acid (NH(2)SO(3)H, SA) was used as an efficient, inexpensive, non-toxic and recyclable green catalyst for the ultrasound-assisted one-pot Mannich reaction of aldehydes with ketones and amines. This ultrasound protocol has advantages of high yield, mild condition, no environmental pollution, and simple work-up procedures. Most importantly, beta-aminocarbonyl compounds with ortho-substituted aromatic amines are obtained in acceptable to good yields by this methodology for the first time.
authors.affiliation: Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China.
authors.forename: Hongyao
authors.initials: H
authors.lastname: Zeng
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Huawu
authors.initials: H
authors.lastname: Shao
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D000431:Ethanol / Q000737:chemistry; D008352:Mannich Bases / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013010:Sonication; D013451:Sulfonic Acids / Q000737:chemistry*; D014465:Ultrasonics
chemical_list: D000447:Aldehydes; D008352:Mannich Bases; D012997:Solvents; D013451:Sulfonic Acids; D000431:Ethanol; C005741:sulfamic acid