title: Unruptured intracranial aneurysms and the assessment of rupture risk based on anatomical and morphological factors: sifting through the sands of data.
abstract: Aneurysmal subarachnoid hemorrhage continues to have high rates of morbidity and mortality for patients despite optimal medical and surgical management. Due to the fact that aneurysmal rupture can be such a catastrophic event, preventive treatment is desirable for high-risk lesions. Given the variability of the literature evaluating unruptured aneurysms regarding basic patient population, clinical practice, and aneurysm characteristics studied, such as size, location, aspect ratio, relationship to the surrounding vasculature, and the aneurysm hemodynamics, a meta-analysis is nearly impossible to perform. This review will instead focus on the various anatomical and morphological characteristics of aneurysms reported in the literature with an attempt to draw broad inferences and serve to highlight pressing questions for the future in our continued effort to improve clinical management of unruptured intracranial aneurysms.
authors.affiliation: Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
authors.forename: Rohan R
authors.initials: RR
authors.lastname: Lall
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Eddleman
authors.forename: Bernard R
authors.initials: BR
authors.lastname: Bendok
authors.forename: H Hunt
authors.initials: HH
authors.lastname: Batjer
mesh_terms: D000886:Anthropometry / Q000379:methods; D002536:Cerebral Arteries / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D002560:Cerebrovascular Circulation / Q000502:physiology; D015897:Comorbidity; D003952:Diagnostic Imaging / Q000379:methods; D018450:Disease Progression; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D018570:Risk Assessment / Q000379:methods; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000453:epidemiology / Q000517:prevention & control*