Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities.
An efficient synthesis of four new acyclic and four new cyclic binaphthyl-based cationic peptoids is described. These compounds had anti-bacterial activities with MIC values of 4-62 microg/mL against Staphylococcus aureus.
Garas
Adel
A
School of Chemistry, University of Wollongong, Wollongong, NSW, Australia.
Bremner
John B
JB
Coates
Jonathan
J
Deadman
John
J
Keller
Paul A
PA
Pyne
Stephen G
SG
Rhodes
David I
DI
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002412:Cations / Q000737:chemistry; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry*; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D002412:Cations; D009281:Naphthalenes; D034444:Peptoids