Presenting manifestations of hemophagocytic syndrome in a male patient with systemic lupus erythematosus.
Hemophagocytic syndrome (HPS) is an unusual but sometimes fatal disorder. We reported a case of 21-year-old man who developed HPS and SLE simultaneously. Febrile pancytopenia, hyperferritinemia, and abnormal liver function tests were observed. Hemophagocytic cells were observed by means of bone marrow biopsy and diagnosed as HPS. The patient was treated with high-dose prednisolone, resulting in an excellent outcome. Early diagnosis of HPS by bone marrow biopsy is important for the successful treatment.
Taki
Hirofumi
H
First Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan. htaki-tym@umin.ac.jp
Shinoda
Koichiro
K
Hounoki
Hiroyuki
H
Ogawa
Reina
R
Hayashi
Ryuji
R
Sugiyama
Eiji
E
Tobe
Kazuyuki
K
D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology / Q000503:physiopathology; D003128:Coma / Q000209:etiology; D005334:Fever / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents; D007564:Japan; D007970:Leukopenia / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D012157:Mononuclear Phagocyte System / Q000473:pathology / Q000503:physiopathology; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
D007166:Immunosuppressive Agents; D011239:Prednisolone; D008775:Methylprednisolone