Three-dimensional fluence rate measurement and data acquisition system for minimally invasive light therapies.
Light based therapies such as photodynamic therapy are in need of advanced tools for light fluence rate dosimetry and monitoring within the context of therapy planning and light delivery to ensure maximum treatment efficacy. The use of a single, multisensor fiber-based fluorescent probe capable of performing spatially resolved fluence rate measurements along an axis was demonstrated. This work extends the previous technique and describes a fluence rate quantification system able to employ up to 12 multisensor probes to simultaneously measure fluence rate distribution throughout a 3D treatment volume. The system optoelectronics provides for sensor calibration, data acquisition, and weighted least-squares processing to extract localized fluence rate information in real-time. Core components include an integrating cylinder for source sensor calibration, a 2D back thin CCD detector for sensor signal detection from multiple probes, high-speed data acquisition card, and custom software for real-time extraction of fluence rate information from all sensors.
Lai
Benjamin
B
Division of Biophysics and Bioimaging, Ontario Cancer Institute, Toronto, Canada.
Loshchenov
Maxim
M
Douplik
Alexander
A
Rusnov
Rob
R
Jimenez-Davila
Marcos
M
Netchev
George
G
Lilge
Lothar
L
D000465:Algorithms; D005456:Fluorescent Dyes; D017075:Laser Coagulation; D007834:Lasers; D010789:Phototherapy / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software; D013997:Time Factors
D005456:Fluorescent Dyes