title: Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles.
abstract: Multistep in flow: The Seyferth-Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three-step oxidation/homologation/copper(I)-catalyzed azide-alkyne cycloaddition sequence without isolation of intermediates (see scheme).
authors.affiliation: ITC, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Mansfield
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Smith
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis*
chemical_list: D000480:Alkynes; D006571:Heterocyclic Compounds; D014230:Triazoles