Post-translational modifications of Runx1 regulate its activity in the cell.
In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.
Wang
Lan
L
Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Huang
Gang
G
Zhao
Xinyang
X
Hatlen
Megan A
MA
Vu
Ly
L
Liu
Fan
F
Nimer
Stephen D
SD
D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D050676:Core Binding Factor Alpha 2 Subunit / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D019175:DNA Methylation; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D008780:Methyltransferases / Q000378:metabolism; D011499:Protein Processing, Post-Translational
D050676:Core Binding Factor Alpha 2 Subunit; D008780:Methyltransferases; D000123:Acetyltransferases; D006655:Histone Deacetylases