title: Neonatal blue-light phototherapy does not increase nevus count in 9-year-old children.
abstract: OBJECTIVE
  One of the most important risk factors for melanoma is the number of acquired common and atypical nevi in childhood. The role played by neonatal blue-light phototherapy in the increasing incidence of common and atypical melanocytic nevi in childhood or adolescence has been discussed recently with discordant results.
  
  
  METHODS
  We designed a multicenter study to assess the effects of neonatal blue-light phototherapy on nevus count in a cohort of 9-year-old children. We counted back and arm nevi as a function of size in 828 children included in a French photoprotection educational campaign. History of neonatal phototherapy, phototype, skin, hair and eye color, and sunburn were assessed through questionnaires to which both parents and children responded, and a nevus count was performed by trained nurses blinded to phototherapy history.
  
  
  RESULTS
  Mean nevus count was 16.7 per child. Twenty-two percent of the children had received neonatal blue-light phototherapy. Neonatal phototherapy had no effect on the nevus count irrespective of nevi location, nevi size, or phototype of the children. A light phototype, skin, and hair color; blue/green eyes; and history of sunburn were closely correlated with an increase in nevus count.
  
  
  CONCLUSIONS
  This study found no evidence for a major role of blue-light phototherapy on nevus count in 9-year-old children. It underlines the dominant effect of phototype characteristics and history of sunburn in childhood on the early development of melanocytic nevi.
authors.affiliation: Service de Dermatologie, Centre Hospitalier Universitaire Ambroise Paré, 9 Ave Charles de Gaulle, 92100 Boulogne-Billancourt, France. emmanuel.mahe@apr.aphp.fr
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mahé
authors.forename: Alain
authors.initials: A
authors.lastname: Beauchet
authors.forename: Philippe
authors.initials: P
authors.lastname: Aegerter
authors.forename: Philippe
authors.initials: P
authors.lastname: Saiag
mesh_terms: D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009508:Nevus, Pigmented / Q000453:epidemiology*; D010789:Phototherapy / Q000009:adverse effects; D012878:Skin Neoplasms / Q000453:epidemiology*; D013471:Sunburn / Q000150:complications