title: Development of wearable optical topography system for mapping the prefrontal cortex activation.
abstract: Optical topography (OT) based on near infrared spectroscopy is effective for measuring changes in the concentrations of oxygenated hemoglobin (oxy-Hb) and deoxygenated hemoglobin (deoxy-Hb) in the brain. It can be used to investigate brain functions of subjects of all ages because it is noninvasive and less constraining for subjects. Conventional OT systems use optical fibers to irradiate the scalp and detect light transmitted through the tissue in the human head, but optical fibers limit the subject's head position, so some small systems have been developed without using optical fibers. These systems, however, have a small number of measurement channels. We developed a prototype of a small, light, and wearable OT system that covers the entire forehead. We measured changes in the concentrations of oxy-Hb and deoxy-Hb in the prefrontal cortex while a subject performed a word fluency task. The results show typical changes in oxy-Hb and deoxy-Hb during the task and suggest that the prototype of our system can be used to investigate functions in the prefrontal cortex.
authors.affiliation: Advanced Research Laboratory, Hitachi, Ltd., 2520 Akanuma, Hatoyama, Saitama 350-0395, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Atsumori
authors.forename: Masashi
authors.initials: M
authors.lastname: Kiguchi
authors.forename: Akiko
authors.initials: A
authors.lastname: Obata
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sato
authors.forename: Takusige
authors.initials: T
authors.lastname: Katura
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Funane
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maki
mesh_terms: D001931:Brain Mapping / Q000295:instrumentation*; D004867:Equipment Design; D005260:Female; D005546:Forehead; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D018670:Monitoring, Ambulatory / Q000295:instrumentation; D010108:Oxyhemoglobins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin