[Consequences of insulin resistance on lipid profile in type2 diabetics group: study of 118 cases].
Insulin is a hormone which has an essential role in lipids metabolism by modulating the activity of many key enzymes and by its intervention on the production and the catabolism of lipoproteins. The aim of this study was to determine the influence of insulin resistance on lipid profile in a diabetic group. The study group consists of 118 diabetic patients. We assayed for each patient total cholesterol, high density lipoprotein cholesterol, triglycerides and insulin. Insulin resistance was determined by HOMA index. Insulin was found correlated to body mass index, triglycerides, waist circumference, and glycated haemoglobin. Triglycerides and glycated haemoglobin were significantly more elevated in insulin resistant group than in insulin sensitive group. Insulin resistance may be the initial anomaly in type 2 diabetes and incite us to search on molecular anomalies in the insulin action.
El Oudi
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Service de Biochimie de l'Hôpital Militaire de Tunis, 1008 Montfleury.
Aouni
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Mazigh
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Essaies
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Zidi
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Machghoul
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D001786:Blood Glucose; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000235:genetics; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D015228:Hypertriglyceridemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood; D014416:Tunisia / Q000453:epidemiology; D055105:Waist Circumference
D001786:Blood Glucose; D002784:Cholesterol; D008076:Cholesterol, HDL; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D006442:Glycated Hemoglobin; D014280:Triglycerides; C085126:FOXO1 protein, human