title: [Brain tuberculomas: six cases].
abstract: BACKGROUND
  Despite the resurgence of tuberculosis, partly due to HIV infection, central nervous system involvement remains rare, accounting for only 2 to 5% of all tuberculosis forms. PATIENTS ET METHOD: We report six cases of brain tuberculomas occurring in patients free of HIV infection and hospitalized between 2001 and 2006 in the internal medicine department of a Tunisian military hospital (Tunis).
  
  
  RESULTS
  Four patients had an underlying defect. Headache, fever, consciousness disorders, deficit disorder or cerebellar syndrome are the main symptoms. Tuberculomas were multiple and disseminated in four cases and localized in the brain stem in two cases. Positive diagnosis could be established in two cases on the basis of the pathology results of a brain biopsy or detection of Mycobacterium tuberculosis in the cerebrospinal fluid; the diagnosis was presumptive in the other cases. Five patients recovered under antituberculosis treatment maintained on average 13 months (11 to 16 months). Steroid treatment was associated in five patients and tapered off for four to six weeks. One 78-year-old diabetic patient died in a context of cachexia with multiple organ failure.
authors.affiliation: Service de médecine interne, hôpital militaire de Tunis, Montfleury, 1008 Tunis, Tunisie. battikh_riadh@yahoo.fr
authors.forename: R
authors.initials: R
authors.lastname: Battikh
authors.forename: M
authors.initials: M
authors.lastname: Yedeas
authors.forename: J
authors.initials: J
authors.lastname: Labidi
authors.forename: N
authors.initials: N
authors.lastname: Ben Abdelhafidh
authors.forename: J
authors.initials: J
authors.lastname: Zaouali
authors.forename: A
authors.initials: A
authors.lastname: Sellami
authors.forename: R
authors.initials: R
authors.lastname: Mrissa
authors.forename: O
authors.initials: O
authors.lastname: Azzouz
authors.forename: B
authors.initials: B
authors.lastname: Louzir
authors.forename: M
authors.initials: M
authors.lastname: Ben Moussa
authors.forename: N
authors.initials: N
authors.lastname: Ben Abdallah
authors.forename: S
authors.initials: S
authors.lastname: Othmani
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014375:Tuberculoma / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology
chemical_list: D000995:Antitubercular Agents