Effects of selenium and L-carnitine on oxidative stress in blood of rat induced by 2.45-GHz radiation from wireless devices.
The levels of blood lipid peroxidation, glutathione peroxidase, reduced glutathione, and vitamin C were used to follow the level of oxidative damage caused by 2.45 GHz electromagnetic radiation in rats. The possible protective effects of selenium and L-carnitine were also tested and compared to untreated controls. Thirty male Wistar Albino rats were equally divided into five groups, namely Groups A1 and A2: controls and sham controls, respectively; Group B: EMR; Group C: EMR + selenium, Group D: EMR + L-carnitine. Groups B–D were exposed to 2.45 GHz electromagnetic radiation during 60 min/ day for 28 days. The lipid peroxidation levels in plasma and erythrocytes were significantly higher in group B than in groups A1 and A2 (p<0.05), although the reduced glutathione and glutathione peroxidase values were slightly lower in erythrocytes of group B compared to groups A1 and A2. The plasma lipid peroxidation level in group A2 was significantly lower than in group B (p<0.05). Erythrocyte reduced glutathione levels (p<0.01) in group B; erythrocyte glutathione peroxidase activity in group A2 (p<0.05), group B (p<0.001), and group C (p<0.05) were found to be lower than in group D. In conclusion, 2.45 GHz electromagnetic radiation caused oxidative stress in blood of rat. L-carnitine seems to have protective effects on the 2.45-GHz-induced blood toxicity by inhibiting free radical supporting antioxidant redox system although selenium has no effect on the investigated values.
Gumral
Nurhan
N
Department of Physiology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey.
Naziroglu
Mustafa
M
Koyu
Ahmet
A
Ongel
Kurtulus
K
Celik
Omer
O
Saygin
Mustafa
M
Kahriman
Mesud
M
Caliskan
Sadettin
S
Kayan
Mustafa
M
Gencel
Osman
O
Flores-Arce
Manuel F
MF
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood; D002331:Carnitine / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*
D000975:Antioxidants; D005979:Glutathione Peroxidase; D005978:Glutathione; D012643:Selenium; D001205:Ascorbic Acid; D002331:Carnitine