High salt intake elevated blood pressure but not changed circadian blood pressure rhythm in Otsuka Long-Evans Tokushima Fatty (OLETF) rat.
We examined the effect of high salt intake on mean arterial pressure and circadian blood pressure rhythm in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of type II diabetes mellitus. Mean arterial pressure, fasting blood glucose, and fasting plasma insulin in OLETF rats were higher than those in LETO rats, their normoglycemic controls. The amplitude of circadian blood pressure rhythm in LETO rats was smaller than that in OLETF rats. High salt intake elevated blood pressure and exacerbated hyperinsulinemia, but did not change the circadian blood pressure rhythm in OLETF rats.
Matsumoto
Mika
M
Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Japan.
Tsujino
Takeshi
T
Naito
Yoshiro
Y
Sakoda
Tsuyoshi
T
Ohyanagi
Mitsumasa
M
Nonaka
Hidemi
H
Masuyama
Tohru
T
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D004195:Disease Models, Animal; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007328:Insulin / Q000097:blood; D008297:Male; D011507:Proteinuria / Q000652:urine; D051381:Rats; D020334:Rats, Inbred OLETF; D020318:Rats, Long-Evans; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D017673:Sodium Chloride, Dietary