title: Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis.
abstract: The stromal vascular fraction (SVF) of adipose tissue is known to contain mesenchymal stem cells (MSC), T regulatory cells, endothelial precursor cells, preadipocytes, as well as anti-inflammatory M2 macrophages. Safety of autologous adipose tissue implantation is supported by extensive use of this procedure in cosmetic surgery, as well as by ongoing studies using in vitro expanded adipose derived MSC. Equine and canine studies demonstrating anti-inflammatory and regenerative effects of non-expanded SVF cells have yielded promising results. Although non-expanded SVF cells have been used successfully in accelerating healing of Crohn's fistulas, to our knowledge clinical use of these cells for systemic immune modulation has not been reported. In this communication we discuss the rationale for use of autologous SVF in treatment of multiple sclerosis and describe our experiences with three patients. Based on this rationale and initial experiences, we propose controlled trials of autologous SVF in various inflammatory conditions.
authors.affiliation: Medistem Inc, San Diego, CA, USA. riordan@medisteminc.com
authors.forename: Neil H
authors.initials: NH
authors.lastname: Riordan
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Ichim
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Min
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Fabio
authors.initials: F
authors.lastname: Solano
authors.forename: Fabian
authors.initials: F
authors.lastname: Lara
authors.forename: Miguel
authors.initials: M
authors.lastname: Alfaro
authors.forename: Jorge Paz
authors.initials: JP
authors.lastname: Rodriguez
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Harman
authors.forename: Amit N
authors.initials: AN
authors.lastname: Patel
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murphy
authors.forename: Roland R
authors.initials: RR
authors.lastname: Lee
authors.forename: Boris
authors.initials: B
authors.lastname: Minev
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D000818:Animals; D016026:Bone Marrow Transplantation; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D004285:Dogs; D006736:Horses; D006801:Humans; D008213:Lymphocyte Activation; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D023421:Models, Animal; D009103:Multiple Sclerosis / Q000601:surgery / Q000628:therapy*; D017154:Stromal Cells / Q000637:transplantation*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology / Q000502:physiology