title: Lichen sclerosus of the oral mucosa: clinicopathological features of six cases.
abstract: Lichen sclerosus is a chronic inflammatory mucocutaneous disease, rarely involving the mouth. There are only 20 well-documented cases of oral lichen sclerosus reported in the English-language literature. This report describes the clinicopathological features of 6 cases of oral lichen sclerosus; 5 in women. There were 12 lesions, mainly on the lips (50%) and buccal mucosa (25%). The affected areas appeared as irregular whitish patches, harder than the surrounding tissue. Half of the patients were symptomatic and presented with no associated skin and/or genital lesions. All cases were biopsied, and histopathological features were evaluated using hematoxylin-eosin and Verhoeff's stains, S-100 immunohistochemical reaction and transmission electron microscopy. Management of the oral lesions consisted of surgical excision, intralesional triamcinolone acetonide, oral colchicine, and regular follow-up. There is no effective curative treatment, but there are some options for patient management; and colchicine may be considered an additional choice.
authors.affiliation: Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas, Sao Paulo, Brazil.
authors.forename: R S
authors.initials: RS
authors.lastname: Azevedo
authors.forename: M J
authors.initials: MJ
authors.lastname: Romañach
authors.forename: O P
authors.initials: OP
authors.lastname: de Almeida
authors.forename: A
authors.initials: A
authors.lastname: Mosqueda-Taylor
authors.forename: M E
authors.initials: ME
authors.lastname: Vega-Memije
authors.forename: R
authors.initials: R
authors.lastname: Carlos-Bregni
authors.forename: E
authors.initials: E
authors.lastname: Contreras-Vidaurre
authors.forename: P
authors.initials: P
authors.lastname: López-Jornet
authors.forename: A
authors.initials: A
authors.lastname: Saura-Inglés
authors.forename: J
authors.initials: J
authors.lastname: Jorge
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D002648:Child; D003078:Colchicine / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D015552:Injections, Intralesional; D018459:Lichen Sclerosus et Atrophicus / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008047:Lip Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D008297:Male; D046529:Microscopy, Electron, Transmission; D009059:Mouth Diseases / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D009061:Mouth Mucosa / Q000473:pathology; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis; D014060:Tongue Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D009418:S100 Proteins; D014222:Triamcinolone Acetonide; D003078:Colchicine