title: Triadin: what possible function 20 years later?
abstract: During the last 20 years, the identification of triadin function in cardiac and skeletal muscle has been the focus of numerous studies. First thought of as the missing link between the ryanodine receptor and the dihydropyridine receptor and responsible of skeletal type excitation-contraction coupling, the current hypothesis on triadin function has slowly evolved, and triadin is envisaged now as a regulator of calcium release, both in cardiac and skeletal muscle. Nevertheless, none of the experiments performed up to now has given a clear cut view of what triadin really does in muscle. The problem became more complex with the identification of multiple triadin isoforms, having possibly multiple functions. Using a different approach from what has been done previously, we have obtained new clues about the function of triadin. Our data point to a possible involvement of triadin in reticulum structure, in relation with the microtubule network.
authors.affiliation: INSERM U, Grenoble Institut des Neurosciences, France. isabelle.marty@ujf-grenoble.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Marty
authors.forename: Julien
authors.initials: J
authors.lastname: Fauré
authors.forename: Anne
authors.initials: A
authors.lastname: Fourest-Lieuvin
authors.forename: Stéphane
authors.initials: S
authors.lastname: Vassilopoulos
authors.forename: Sarah
authors.initials: S
authors.lastname: Oddoux
authors.forename: Julie
authors.initials: J
authors.lastname: Brocard
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000266:history / Q000502:physiology*; D006321:Heart / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009124:Muscle Proteins / Q000737:chemistry / Q000235:genetics / Q000266:history / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D051381:Rats
chemical_list: D002352:Carrier Proteins; D009124:Muscle Proteins; D020033:Protein Isoforms; C070048:triadin