title: PRNP haplotype distribution in Moroccan goats.
abstract: Susceptibility/resistance to scrapie in sheep and goats is influenced by host prion protein gene (PRNP) genotype. In this study, we report the analysis of prion protein gene polymorphisms in 137 goats of two Moroccan populations: D'man and Chaouni. We found seven previously described amino acid polymorphisms at codons 37, 127, 137, 142, 154, 222 and 240, as well as three known silent mutations. In addition, we identified three new allelic variants: 101R and 139S in D'man goats and 145D in D'man and Chaouni individuals. The high frequency of the resistant allele 154H could offer genetic protection against the disease to the analysed animals. A total of 12 haplotypes and 28 genotypes were found, the distribution of which shows significant differences between both groups. Moreover, haplotype frequencies were compared with bibliographic data showing that the haplotype distribution of PRNP in Moroccan populations is genetically similar to Southern Italian and Greek goats.
authors.affiliation: Laboratorio de Genética Bioquímica, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza 50013, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Serrano
authors.forename: M
authors.initials: M
authors.lastname: Hammouchi
authors.forename: A
authors.initials: A
authors.lastname: Benomar
authors.forename: J
authors.initials: J
authors.lastname: Lyahyai
authors.forename: B
authors.initials: B
authors.lastname: Ranera
authors.forename: C
authors.initials: C
authors.lastname: Acín
authors.forename: M
authors.initials: M
authors.lastname: el Hamidi
authors.forename: M
authors.initials: M
authors.lastname: Monzón
authors.forename: J J
authors.initials: JJ
authors.lastname: Badiola
authors.forename: N
authors.initials: N
authors.lastname: Tligui
authors.forename: P
authors.initials: P
authors.lastname: Zaragoza
authors.forename: I
authors.initials: I
authors.lastname: Martín-Burriel
mesh_terms: D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D005787:Gene Frequency; D006041:Goats / Q000235:genetics*; D006239:Haplotypes; D009018:Morocco; D010802:Phylogeny; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics*
chemical_list: D011328:Prions