Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population.
Genetic factor may play a role in the pathogenesis of kidney stone that is found in the northeastern (NE) Thai population. Herein, we report initial evidence suggesting genetic contribution to the disease in this population. We examined 1,034 subjects including 135 patients with kidney stone, 551 family members, and 348 villagers by radiography of kidney-ureter-bladder (KUB) and other methods, and also analyzed stones removed by surgical operations. One hundred and sixteen of 551 family members (21.05%) and 23 of the 348 villagers (6.61%) were affected with kidney stone. The relative risk (lambda(R)) of the disease among family members was 3.18. Calcium stones (whewellite, dahllite, and weddellite) were observed in about 88% of stones analyzed. Our data indicate familial aggregation of kidney stone in this population supporting that genetic factor should play some role in its pathogenesis. Genetic and genomic studies will be conducted to identify the genes associated with the disease.
Sritippayawan
Suchai
S
Division of Nephrology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Borvornpadungkitti
Sombat
S
Paemanee
Atchara
A
Predanon
Chagkrapan
C
Susaengrat
Wattanachai
W
Chuawattana
Duangporn
D
Sawasdee
Nunghathai
N
Nakjang
Sirintra
S
Pongtepaditep
Suttikarn
S
Nettuwakul
Choochai
C
Rungroj
Nanyawan
N
Vasuvattakul
Somkiat
S
Malasit
Prida
P
Yenchitsomanus
Pa-thai
PT
D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D014514:Ureteral Calculi / Q000737:chemistry / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D055815:Young Adult