title: Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
abstract: Suppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex. Herein, we present the results of structure-activity relationship studies of these compounds.
authors.affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
authors.forename: Jianming
authors.initials: J
authors.lastname: Lu
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Ma
authors.forename: Jen-Chieh
authors.initials: JC
authors.lastname: Hsieh
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Fan
authors.forename: Baozhi
authors.initials: B
authors.lastname: Chen
authors.forename: Jamie C
authors.initials: JC
authors.lastname: Longgood
authors.forename: Noelle S
authors.initials: NS
authors.lastname: Williams
authors.forename: James F
authors.initials: JF
authors.lastname: Amatruda
authors.forename: Lawrence
authors.initials: L
authors.lastname: Lum
authors.forename: Chuo
authors.initials: C
authors.lastname: Chen
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry*; D000818:Animals; D060466:Axin Protein; D007094:Imides / Q000737:chemistry*; D012097:Repressor Proteins / Q000378:metabolism; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D013623:Tail; D051153:Wnt Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015027:Zebrafish / Q000378:metabolism
chemical_list: D000634:Aminoquinolines; D060466:Axin Protein; D007094:Imides; D012097:Repressor Proteins; D051153:Wnt Proteins