title: Modern concepts in the diagnosis and treatment of vitamin D deficiency and its clinical consequences.
abstract: It is the purpose of this comprehensive report to outline a revolutionary strategy to prevent vitamin D deficiency in our nation. Vitamin D is a unique vitamin. Its metabolic product, calcitriol, is a profound secosteroid hormone that has impact on over 1000 genes in the human body. Recent clinical research has implicated vitamin D deficiency as a major factor in the etiology of rickets, a wide variety of cancers, as well as hypertension, stroke, heart attack, diabetes, bone fractures, periodontal disease, and even multiple sclerosis. There are two forms of vitamin D utilized in the human body: D2 and D3. Measurement of 25(OH)D is the most reliable method of detecting vitamin D deficiency. Several methods, including high-performance liquid chromatography (HPLC), chemoluminescence, and radioimmunoassay (RIA), have been developed for the measurement of total 25(OH)D levels. Prevention and treatment of vitamin D deficiency is accomplished by regulated sun exposure as well as vitamin D, supplementation. This information describing our plan to prevent vitamin D deficiency in the patients and employees of Legacy Health System is a landmark accomplishment that should be replicated in every healthcare setting in our country to prevent vitamin D deficiency.
authors.affiliation: University of Virginia Health System, Charlottesvill, VA, USA. richardedlich@gmail.com
authors.forename: Richard
authors.initials: R
authors.lastname: Edlich
authors.forename: Allyson L
authors.initials: AL
authors.lastname: Fisher
authors.forename: Margot E
authors.initials: ME
authors.lastname: Chase
authors.forename: Carroll M
authors.initials: CM
authors.lastname: Brock
authors.forename: K
authors.initials: K
authors.lastname: Gubler
authors.forename: William B
authors.initials: WB
authors.lastname: Long
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D019587:Dietary Supplements; D006801:Humans; D013472:Sunlight; D053719:Tandem Mass Spectrometry; D014193:Trauma Centers; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000175:diagnosis* / Q000517:prevention & control*
chemical_list: D014807:Vitamin D