title: Aggression, psychopathy and brain imaging - Review and future recommendations.
abstract: Violent behavior appears to result from a complex web of interacting genetic as well as environmental factors. Psychopathy is a strong predictor for relapse in violent acts. The current review shed light on rapidly expanding knowledge in brain imaging related to violent behavior and psychopathy. A literature search was performed in PubMed, Cochrane and PsycInfo combining the key words: mentally disordered offender/aggression/violence/ crime/forensic psychiatry/brain imaging neuroimaging/fMRI/MRI/PET/SPECT/lack of empathy/psychopathy and antisocial personality disorder. The reviewed material, which consisted of 48 articles, indicates a rather strong consensus on the connection between dysfunctional parts of the frontal and temporal lobes and violent antisocial behavior and psychopathy. In future studies, it would be useful to focus on the limbic system and to investigate which parts of the frontal lobes and cerebral networks that are of interest in the psychopathic personality. Moreover, the reviewed material highlights some of the methodological difficulties in this area of research such as selection bias in the recruitment of patients, inadequate matching of control subjects, and sometimes incongruous results. In the future we hope that brain imaging can be used to map biological deviations in different offenders in order to try to learn more about the different mechanisms behind violent behaviors.
authors.affiliation: Karolinska Institutet, Stockholm, Sweden. katarina.wahlund@ki.se
authors.forename: Katarina
authors.initials: K
authors.lastname: Wahlund
authors.forename: Marianne
authors.initials: M
authors.lastname: Kristiansson
mesh_terms: D000374:Aggression / Q000502:physiology*; D001921:Brain / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D003952:Diagnostic Imaging; D006801:Humans; D011599:Psychopathology; D011859:Radiography