Three new triterpenoid saponins from the leaves and stems of Panax quinquefolium.
Three new minor dammarane saponins, quinquenosides L10 (1), L14 (2), and L16 (3), were isolated from the leaves and stems of Panax quinquefolium L. By the combination of one- and two-dimensional NMR techniques and MS spectroscopic analysis, their structures were established as 20-O-(alpha-L-arabinopyranosyl-(1-6)-O-beta-D-glucopyranosyl)-3-O-beta-D-glucopyranosyl-dammar-24-ene-3,12, 20-triol (1), 20-O-alpha-L-arabinopyranosyl-3-O-(beta-D-glucopyranosyl-(1-2)-O-beta-d-glucopyranosyl)-dammar-24-ene-3,12,20-triol (2), 3-O-(beta-D-glucopyranosyl-(1-2)-O-beta-d-glucopyranosyl)-20-O-(beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl)-dammarane-3,12,20,24,25-pentaol (3). The content of artemisinin was significantly enhanced by 3.0 mg l(- 1) of compounds 1, 2, and 3 in the callus of Artemisia annua.
Chen
Jing
J
Department of Natural Medicines, Shenyang Pharmaceutical University, Shenyang, China.
Zhao
Rui
R
Zeng
Yi-Mei
YM
Meng
Hei
H
Zuo
Wen-Jian
WJ
Li
Xian
X
Wang
Jin-Hui
JH
D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D036145:Ginsenosides / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D005894:Panax / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification*; D000097669:Dammaranes
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D014315:Triterpenes; D000097669:Dammaranes; C540460:quinquenoside L10; C540461:quinquenoside L14; C540462:quinquenoside L16