Lipids in Ca2+ signalling--an introduction.
Lipids and lipid-derived metabolites are increasingly recognised as bonafide signalling molecules that regulate many cellular processes. These include the well-established InsP(3), diacylglycerol (DAG), PIP(2), PIP(3) and arachidonic acid (AA), as well as other poly-unsaturated fatty acids (PUFAs), lysophospholipids, sphingolipids, endocannabinoids and endovanilloids. They regulate a plethora of molecules that are involved in Ca(2+) signalling, including various ion channels, pumps and transporters, thereby triggering, modulating and fine-tuning Ca(2+) signals. Although appreciated individually, it seems timely to highlight the overall impact of lipids as signalling molecules and their role in Ca(2+) signalling, and this is the aim of this special issue of Cell Calcium.
Hardie
Roger C
RC
Department of Physiology Development and Neuroscience, Cambridge University, Downing St, Cambridge, United Kingdom. rch14@cam.ac.uk
Muallem
Shmuel
S
D016718:Arachidonic Acid / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D008055:Lipids / Q000502:physiology*; D010716:Phosphatidylinositols / Q000378:metabolism; D010740:Phospholipases / Q000378:metabolism; D015398:Signal Transduction; D050051:Transient Receptor Potential Channels / Q000378:metabolism
D015220:Calcium Channels; D008055:Lipids; D010716:Phosphatidylinositols; D050051:Transient Receptor Potential Channels; D016718:Arachidonic Acid; D010740:Phospholipases; D002118:Calcium