title: Panic disorder and a possible treatment approach by means of high-frequency rTMS: a case report.
abstract: Panic disorder still remains a pervasive, life quality impairing disorder requiring adequate treatment options. In this case report we present the data of a patient with panic disorder and comorbid depression who was treated with high-frequency repetitive transcranial magnetic stimulation (rTMS) applied to the left prefrontal cortex over a course of 3 weeks. Measurements of the cerebral oxygenation with near-infrared spectroscopy (NIRS) during an emotional Stroop task before and after the rTMS treatment suggests that rTMS may modulate panic-related prefrontal brain dysfunctions in panic patients and that it may serve as a possible treatment option for anxiety disorders.
authors.affiliation: Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany. Dresler_T@klinik.uni-wuerzburg.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Dresler
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Ehlis
authors.forename: Michael M
authors.initials: MM
authors.lastname: Plichta
authors.forename: Melany M
authors.initials: MM
authors.lastname: Richter
authors.forename: Burkhard
authors.initials: B
authors.lastname: Jabs
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Lesch
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Fallgatter
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000627:therapeutic use; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use; D017298:Bisoprolol / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D018757:GABA Modulators / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000188:drug therapy / Q000628:therapy*; D013449:Sulfonamides / Q000627:therapeutic use; D000077409:Tamsulosin; D013693:Temazepam / Q000627:therapeutic use; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D018757:GABA Modulators; D013449:Sulfonamides; D000639:Amitriptyline; D013693:Temazepam; D000077409:Tamsulosin; D017298:Bisoprolol