title: Epidermoid anal cancer prognosis comparison among HIV+ and HIV- patients.
abstract: BACKGROUND
  Previous studies suggest a poor prognosis of epidermoid anal cancer in HIV+ patients.
  
  
  OBJECTIVE
  To investigate the long-term outcome of epidermoid anal cancer in HIV+ and HIV- patients in the highly active antiretroviral treatment (HAART) era.
  
  
  METHODS
  We included all patients with epidermoid anal cancer referred to six hospitals from 1998 to 2004.
  
  
  RESULTS
  In all, 151 patients (44 HIV+, 107 HIV-) were reviewed retrospectively for 27 (median of 16-44) months. HIV+ patients were male (100% vs. 27%, P < 0.001) and younger (45 vs. 62 years old, P < 0.001) than HIV- patients. No significant differences were observed in the tumour stage, pelvic radiotherapy dose or concomitant chemotherapy, according to the HIV status. After chemoradiotherapy, similar numbers of HIV+ and HIV- patients had grade III-IV toxicity. A complete response was obtained in 82% and 75% (N.S.) of cases, respectively. The disease-free survival rates were 77% and 67% (N.S.) and the overall survival rates were 85% and 84% (N.S.), respectively, after 3 years of follow-up. Duration of HIV infection, viral load and CD4 count had no effect on the survival rate of HIV+ patients with EAC.
  
  
  CONCLUSIONS
  The clinical outcome of HIV+ patients with epidermoid anal cancer is similar to that of HIV- patients. Therefore, the same therapeutic guidelines should be applied to both populations.
authors.affiliation: AP-HP, Service de gastroentérologie et Unité de proctologie medico-chirurgicale, Hôpital Universitaire Bichat, Paris, CEDEX, France. laurent.abramowitz@bch.aphp.fr
authors.forename: L
authors.initials: L
authors.lastname: Abramowitz
authors.forename: N
authors.initials: N
authors.lastname: Mathieu
authors.forename: F
authors.initials: F
authors.lastname: Roudot-Thoraval
authors.forename: N
authors.initials: N
authors.lastname: Lemarchand
authors.forename: P
authors.initials: P
authors.lastname: Bauer
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
authors.forename: E
authors.initials: E
authors.lastname: Mitry
authors.forename: C
authors.initials: C
authors.lastname: Romelaer
authors.forename: T
authors.initials: T
authors.lastname: Aparicio
authors.forename: I
authors.initials: I
authors.lastname: Sobhani
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D001005:Anus Neoplasms / Q000401:mortality / Q000628:therapy* / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy* / Q000821:virology; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006679:HIV Seropositivity / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D013223:Statistics as Topic; D011795:Surveys and Questionnaires; D015996:Survival Rate; D016896:Treatment Outcome