First detection of plasmid-encoded blaOXY beta-lactamase.
Three Klebsiella oxytoca isolates and one Klebsiella pneumoniae isolate from three children admitted to the Hematology Unit of Hospital Vall d'Hebron (Barcelona, Spain) exhibited a susceptibility pattern suggesting OXY beta-lactamase hyperproduction. All the isolates contained a 95-kb plasmid that harbored bla(OXY-1), which was transferred by electrotransformation but could not be self-transferred by conjugation. A qnrS1 gene was also harbored in the bla(OXY-1)-carrying plasmid. This is the first report of a plasmid-encoded OXY beta-lactamase.
González-López
J J
JJ
Department of Microbiology, Hospital Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona, Spain. jjgonzalez@ir.vhebron.net
Coelho
A
A
Larrosa
M N
MN
Lavilla
S
S
Bartolomé
R
R
Prats
G
G
D015139:Blotting, Southern; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D007709:Klebsiella / Q000201:enzymology* / Q000235:genetics*; D041121:Klebsiella oxytoca / Q000187:drug effects / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics; D008297:Male; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics*; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics*
D001618:beta-Lactamases