title: Metabolic labeling of sialic acids in living animals with alkynyl sugars.
abstract: Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl)mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.
authors.affiliation: Department of Chemistry and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
authors.forename: Pamela V
authors.initials: PV
authors.lastname: Chang
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.forename: Chris
authors.initials: C
authors.lastname: Smyrniotis
authors.forename: Alexander
authors.initials: A
authors.lastname: Xenakis
authors.forename: Tianshun
authors.initials: T
authors.lastname: Hu
authors.forename: Carolyn R
authors.initials: CR
authors.lastname: Bertozzi
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
mesh_terms: D000818:Animals; D001386:Azides / Q000494:pharmacology*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D006023:Glycoproteins / Q000378:metabolism*; D006595:Hexosamines / Q000494:pharmacology*; D006801:Humans; D019169:Jurkat Cells; D051379:Mice; D012794:Sialic Acids / Q000378:metabolism*
chemical_list: D001386:Azides; D006023:Glycoproteins; D006595:Hexosamines; C405953:N-azidoacetylmannosamine; D012794:Sialic Acids