title: Diagnostic evaluation of platelet function disorders in neonates and children: an update.
abstract: Investigation of platelet function disorders in infants and small children requires the collaborative efforts of clinicians and clinical laboratories. A detailed personal, family, and medication history, and a search for additional clinical phenomena may help to direct diagnostic laboratory investigations. Testing for these disorders in young children presents several challenges: the requirement of relatively large volumes of blood, lack of standardization, and the absence of well-established age-specific reference ranges. Neonates show the most notable differences in platelet function compared to older children and adults; the decreased platelet activation responses persist for the first 2 to 4 weeks after delivery. Small studies of normal postneonatal pediatric populations have provided data on platelet function assays, including bleeding times, PFA-100 closure times, thromboelastography, aggregation, secretion, and flow cytometry. The majority of these studies, comparing normal children with adults, found only minor differences in platelet responses measured by these assays.
authors.affiliation: Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada. israels@cc.umanitoba.ca
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Israels
mesh_terms: D001780:Blood Coagulation Tests; D001791:Blood Platelet Disorders / Q000097:blood / Q000175:diagnosis*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010979:Platelet Function Tests