[Significance of urinary uracil measurement following administration of DPD inhibitory fluoropyrimidine(DIF)products].
Individual differences in 5-FU metabolism are mainly attributed to individual differences in the activity of DPD, an enzyme that can metabolize more than 85% of 5-FU. Because urinary uracil is a reflection of DPD activity, it is measured to predict and prevent the occurrence of side effects caused by pyrimidine-type chemotherapeutic agents. From urinary uracil values measured in 84 gastrointestinal cancer patients, 0-60 mmol/g.creatinine was set as a standard. In patients whose urinary uracil values exceeded the standard, 5-FU tended to be accumulated when S-1, a DIF product, was administered and side effects, such as anorexia, vomiting and diarrhea occurred immediately after the start of S-1 administration. If an appropriate DIF product is selected and its dosage set based on the patient's urinary uracil value, the occurrence of side effects would be reduced. Subsequently, a continuation of medication would be possible.
Horiuchi
Tetsuya
T
Department of Pharmacy, National Hospital Organization Osakaminami Medical Center.
Shono
Yoshiharu
Y
Miyabe
Takashi
T
Nakajima
Yumi
Y
Akiyama
Isao
I
Uchida
Kagehiro
K
Fujita
Yoshikazu
Y
Hasegawa
Kenji
K
Tabuse
Katsuyoshi
K
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use / Q000652:urine*; D042943:Dihydrouracil Dehydrogenase (NADP) / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004379:Duodenal Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000652:urine; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use / Q000652:urine*; D005260:Female; D017611:Fluorine Compounds / Q000008:administration & dosage / Q000627:therapeutic use / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000652:urine; D014498:Uracil / Q000652:urine*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D017611:Fluorine Compounds; D014498:Uracil; D042943:Dihydrouracil Dehydrogenase (NADP)