title: Decreased percentages of the peripheral blood T-cell subsets and the serum IL-2 contents in chickens fed on diets excess in fluorine.
abstract: Three hundred 1-day-old Avian broilers were divided into four groups and fed on control diet (F 23 ppm) and high-fluorine diets (400 ppm, high-fluorine group I; 800 ppm, high-fluorine group II; 1,200 ppm, high-fluorine group III) for 42 days (n=75/group). The percentages of CD4+ and CD8+ T cells were decreased in three high-fluorine groups when compared with those of control group. Meanwhile, the CD4+/CD8+ ratio were lower in high-fluorine group II at 28 days of age and in high-fluorine group III at 42 days of age than in control group. Also, the serum interleukin-2 (IL-2) contents were decreased in three high-fluorine groups when compared with those of control group. Histopathologically, the thymus became hypocellular in three high-fluorine groups. It was concluded that dietary fluorine excess (400~1,200 ppm) reduced the percentages of T-lymphocyte subsets and the serum IL-2 contents, and cellular immune function could be affected in chickens.
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, Sichuan 625014, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Yun
authors.initials: Y
authors.lastname: Cui
authors.forename: Caimin
authors.initials: C
authors.lastname: Bai
authors.forename: Tao
authors.initials: T
authors.lastname: Gong
authors.forename: Xi
authors.initials: X
authors.lastname: Peng
authors.forename: Hengmin
authors.initials: H
authors.lastname: Cui
mesh_terms: D000818:Animals; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D002645:Chickens; D005434:Flow Cytometry; D005461:Fluorine / Q000008:administration & dosage / Q000009:adverse effects*; D007111:Immunity, Cellular / Q000187:drug effects; D007376:Interleukin-2 / Q000097:blood*; D016176:T-Lymphocyte Subsets / Q000187:drug effects*
chemical_list: D007376:Interleukin-2; D005461:Fluorine