[Clinical significance of some genetic polymorphisms of cytochrome P-450: family CYP1 and subfamilies CYP2A, CYP2B and CYP2C].
The essence of pharmacogenetic studies is to provide a scientific explanation for personal differences in the process of drugs metabolism. Polymorphism of drugs biotransformation is clinically significant from the point of view of the effectiveness and safety of pharmacotherapy and an increased risk of some illnesses. The paper presents molecular mechanisms and clinical implication of several genetic polymorphisms of cytochrome P-450 (CYP) xenobiotics metabolizing enzymes and genetic predisposition to the occurrence of some diseases.
Wojtczak
Anna
A
Pharmacogenetics Department, Medical University of Lodz, Poland. awojt@mp.pl
Skretkowicz
Jadwiga
J
D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D001711:Biotransformation; D021983:Cyclophilins / Q000235:genetics; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D065633:Cytochrome P-450 CYP1B1; D019362:Cytochrome P-450 CYP2B1 / Q000235:genetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D013250:Steroid Hydroxylases / Q000235:genetics; D015262:Xenobiotics / Q000493:pharmacokinetics
D015262:Xenobiotics; C400322:cytochrome P-450 CYP2C subfamily; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D019363:Cytochrome P-450 CYP1A1; D065633:Cytochrome P-450 CYP1B1; D019362:Cytochrome P-450 CYP2B1; C029009:steroid hormone 7-alpha-hydroxylase; D021983:Cyclophilins; C102923:PPIG protein, human