title: [Effect of isomerization of aspartate-7 on the binding of copper (II) ion by the beta-amyloid peptide].
abstract: It has been shown for the first time by the method of isothermal calorimetry of titration that the N-terminal amino group of the beta-amyloid protein, which plays a key role in the binding of copper ion, ceases to form the proper coordinating bond as a result of the isomerization of aspartate-7.
authors.forename: F O
authors.initials: FO
authors.lastname: Tsvetkov
authors.forename: A A
authors.initials: AA
authors.lastname: Makarov
authors.forename: A I
authors.initials: AI
authors.lastname: Archakov
authors.forename: S A
authors.initials: SA
authors.lastname: Kozin
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D001224:Aspartic Acid / Q000737:chemistry* / Q000378:metabolism; D002413:Cations, Divalent / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007536:Isomerism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding
chemical_list: D016229:Amyloid beta-Peptides; D002413:Cations, Divalent; D010455:Peptides; D001224:Aspartic Acid; D003300:Copper