Tumor necrosis factor alpha -C850T polymorphism is significantly associated with endometriosis in Asian Indian women.
OBJECTIVE
To establish the association of tumor necrosis factor alpha (TNFA) promoter C850T polymorphism in Asian Indian women with endometriosis.


METHODS
Case control study, from multiple gynecological centers from Hyderabad, a cosmopolitan city in southern India. The study included 245 women who comprised 110 surgically confirmed cases of endometriosis, 50 ultrasonographically confirmed cases of fibroid tumors, and 85 healthy female volunteers.


METHODS
Academic hospital.


METHODS
The cases were 245 women, 160 patients and 85 controls.


METHODS
None.


METHODS
Tumor necrosis factor alpha -C850T polymorphism may be used as a molecular marker for endometriosis in our population.


RESULTS
In this study we have demonstrated an association between TNFA -C850T polymorphism and endometriosis. The T allele is significantly associated with endometriosis when compared to women with fibroids as well as healthy controls. Our data imply that the T allele is associated with endometriosis (OR = 1.9594: 95% CI, 1.3833-2.7753; in our population. The TT genotype increases the risk of endometriosis by fourfold (4.5542: 95% CI, 2.0388-10.1701.


CONCLUSIONS
This study suggests that -C850T TNFA gene polymorphism could be used as a relevant molecular marker to identify women with risk of developing endometriosis in our population.
Lakshmi
Kodati Vijaya
KV
Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Khairatabad, Hyderabad, India. kovila@gmail.com
Shetty
Preetha
P
Vottam
Kiran
K
Govindhan
Sujatha
S
Ahmad
Shaik Noor
SN
Hasan
Qurratulain
Q
D044466:Asian People / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D004715:Endometriosis / Q000000981:diagnostic imaging / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D014463:Ultrasonography
D005819:Genetic Markers; D014409:Tumor Necrosis Factor-alpha