title: [Bone fracture and the healing mechanisms. Molecular bases of fracture healing].
abstract: Fracture healing is a process comprising of a local bleeding followed by inflammation and differentiation of mesenchymal cells that lead to formation of soft extracellular matrix tissue, cartilage and bone. This pathway includes endo-chondral bone formation and in part intra-membranous bone formation. During this process several sets of cytokines are involved in the regulation of the progress in fracture healing. This paper reviews the molecules involved in fracture healing.
authors.affiliation: Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University.
authors.forename: Masaki
authors.initials: M
authors.lastname: Noda
authors.forename: Masashi
authors.initials: M
authors.lastname: Nagao
authors.forename: Ryo
authors.initials: R
authors.lastname: Hanyu
authors.forename: Kentaro
authors.initials: K
authors.lastname: Miyai
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ezura
mesh_terms: D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D017102:Fracture Healing / Q000235:genetics* / Q000528:radiation effects*; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor; D020780:Matrix Metalloproteinase 9; D010012:Osteogenesis / Q000235:genetics / Q000502:physiology; D053495:Osteopontin; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D053245:RANK Ligand; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A
chemical_list: D019485:Bone Morphogenetic Proteins; D016207:Cytokines; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D053245:RANK Ligand; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D053495:Osteopontin; D016173:Macrophage Colony-Stimulating Factor; D020780:Matrix Metalloproteinase 9