[Effects of sustained-release alpha-lipoic acid tablet on blood lipid, blood sugar and insulin in hyperlipidemic New Zealand rabbits].
OBJECTIVE
To evaluate the effect of sustained-release alpha-lipoic acid tablets (SRLA) on blood lipid, glucose and insulin levels in hyperlipidemic New Zealand rabbits.


METHODS
Twenty-four New Zealand rabbits were randomized into normal diet group, high-fat diet group, and high-fat diet + SRLA (300 mg/tablet) group with corresponding feed. At the beginning and 4 weeks after the feeding, the serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), blood glucose, and serum insulin were measured, and insulin sensitivity index (ISI) was calculated.


RESULTS
Four weeks after feeding with high-fat diet, the insulin levels was elevated and the ISI lowered in the New Zealand rabbits, indicating successful establishment of the animal model of hyperlipidemia. Compared with the high-fat diet group, the serum levels of TG, TC, LDL-C and insulin were significantly reduced (P<0.05), and the ISI was significantly increased (P<0.05) in high fat diet + SRLA group. But no statistically significant difference was found in the blood glucose among the 3 groups.


CONCLUSIONS
SRLA can significantly correct blood lipid and insulin disorders in hyperlipidemic New Zealand rabbits and prevent the occurrence of insulin resistance and hyperlipidemia.
Chen
Xie-sheng
XS
Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Liu
Hong
H
Ji
Ai-min
AM
Yang
Yue-lian
YL
Yao
Yu-fa
YF
Sun
Liang
L
Che
Ou
O
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003692:Delayed-Action Preparations; D006949:Hyperlipidemias / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008297:Male; D011817:Rabbits; D013607:Tablets; D008063:Thioctic Acid / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use
D001786:Blood Glucose; D003692:Delayed-Action Preparations; D007328:Insulin; D008055:Lipids; D013607:Tablets; D008063:Thioctic Acid