An outbreak of postoperative gram-negative bacterial endophthalmitis associated with contaminated trypan blue ophthalmic solution.
We report 6 cases of postsurgical endophthalmitis due to gram-negative bacteria associated with contaminated trypan blue dye from a compounding pharmacy. Unopened trypan blue syringes yielded Pseudomonas aeruginosa and Burkholderia cepacia complex on culture, with pulsed-field gel electrophoresis patterns indistinguishable from patient isolates. Contamination of compounded medications should be considered when investigating outbreaks of postoperative endophthalmitis.
Sunenshine
Rebecca
R
Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Sunensr@azdhs.gov
Schultz
Maureen
M
Lawrence
Mary G
MG
Shin
Soo
S
Jensen
Bette
B
Zubairi
Sabiha
S
Labriola
Ann M
AM
Shams
Alicia
A
Noble-Wang
Judith
J
Arduino
Matthew J
MJ
Gordin
Fred
F
Srinivasan
Arjun
A
D000368:Aged; D000369:Aged, 80 and over; D042602:Burkholderia cepacia complex / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D016000:Cluster Analysis; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D016172:DNA Fingerprinting; D004196:Disease Outbreaks; D004340:Drug Contamination; D016521:Electrophoresis, Gel, Pulsed-Field; D009877:Endophthalmitis / Q000453:epidemiology* / Q000382:microbiology; D005838:Genotype; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000382:microbiology; D014343:Trypan Blue
D009883:Ophthalmic Solutions; D014343:Trypan Blue