title: New irradiation facility for biomedical applications at the RA-3 reactor thermal column.
abstract: A new irradiation facility has been developed in the RA-3 reactor in order to perform trials for the treatment of liver metastases using boron neutron capture therapy (BNCT). RA-3 is a production research reactor that works continuously five days a week. It had a thermal column with a small cross section access tunnel that was not accessible during operation. The objective of the work was to perform the necessary modifications to obtain a facility for irradiating a portion of the human liver. This irradiation facility must be operated without disrupting the normal reactor schedule and requires a highly thermalized neutron spectrum, a thermal flux of around 10(10) n cm(-2)s(-1) that is as isotropic and uniform as possible, as well as on-line instrumentation. The main modifications consist of enlarging the access tunnel inside the thermal column to the suitable dimensions, reducing the gamma dose rate at the irradiation position, and constructing properly shielded entrance gates enabled by logical control to safely irradiate and withdraw samples with the reactor at full power. Activation foils and a neutron shielded graphite ionization chamber were used for a preliminary in-air characterization of the irradiation site. The constructed facility is very practical and easy to use. Operational authorization was obtained from radioprotection personnel after confirming radiation levels did not significantly increase after the modification. A highly thermalized and homogenous irradiation field was obtained. Measurements in the empty cavity showed a thermal flux near 10(10) n cm(-2)s(-1), a cadmium ratio of 4100 for gold foils and a gamma dose rate of approximately 5 Gy h(-1).
authors.affiliation: Instrumentation and Control Department, National Atomic Energy Commission, Argentina. miller@cae.cnea.gov.ar
authors.forename: M
authors.initials: M
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Quintana
authors.forename: J
authors.initials: J
authors.lastname: Ojeda
authors.forename: S
authors.initials: S
authors.lastname: Langan
authors.forename: S
authors.initials: S
authors.lastname: Thorp
authors.forename: E
authors.initials: E
authors.lastname: Pozzi
authors.forename: M
authors.initials: M
authors.lastname: Sztejnberg
authors.forename: G
authors.initials: G
authors.lastname: Estryk
authors.forename: R
authors.initials: R
authors.lastname: Nosal
authors.forename: E
authors.initials: E
authors.lastname: Saire
authors.forename: H
authors.initials: H
authors.lastname: Agrazar
authors.forename: F
authors.initials: F
authors.lastname: Graiño
mesh_terms: D000818:Animals; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation*; D005160:Facility Design and Construction; D005214:Fast Neutrons / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy / Q000556:secondary; D009688:Nuclear Reactors; D011835:Radiation Protection / Q000295:instrumentation