title: Human histologic evaluation of mineralized collagen bone substitute and recombinant platelet-derived growth factor-BB to create bone for implant placement in extraction socket defects at 4 and 6 months: a case series.
abstract: The objective of this pilot study was to assess whether mineralized collagen bone substitute (MCBS) combined with recombinant human platelet-derived growth factor-BB (0.3 mg/mL) would generate adequate viable bone in buccal wall extraction defects to accommodate implant placement. The primary outcome variable was bone quality, as measured by microcomputed tomography and histologic evaluation. This was successfully accomplished in all eight specimens obtained from seven patients. The secondary outcome variables were bone quality and quantity as observed clinically, radiographically, and by the primary stability of implants at the time of placement. Soft tissue healing was excellent, and there were no unanticipated adverse events. Robust bone formation accompanied by MCBS resorption was evident in all 4- and 6-month specimens. This was accomplished without barrier membranes.
authors.affiliation: Department of Oral Medicine, Infection and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Cambridge, Massachusetts, USA. marc_nevins@hms.harvard.edu
authors.forename: Marc L
authors.initials: ML
authors.lastname: Nevins
authors.forename: Marcelo
authors.initials: M
authors.lastname: Camelo
authors.forename: Peter
authors.initials: P
authors.lastname: Schupbach
authors.forename: David M
authors.initials: DM
authors.lastname: Kim
authors.forename: Joao Marcelo Borges
authors.initials: JM
authors.lastname: Camelo
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
mesh_terms: D000328:Adult; D000077214:Becaplermin; D015519:Bone Density; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D017268:Dental Prosthesis Retention; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000494:pharmacology*; D010865:Pilot Projects; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins / Q000494:pharmacology; D013997:Time Factors; D020390:Tooth Socket / Q000601:surgery*; D055114:X-Ray Microtomography
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D004338:Drug Combinations; D008903:Minerals; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin