title: Troponin is superior to electrocardiogram and creatinine kinase MB for predicting clinically significant myocardial injury after coronary artery bypass grafting.
abstract: OBJECTIVE
  Cardiac biomarkers are routinely elevated after uncomplicated cardiac surgery to levels considered diagnostic of myocardial infarction in ambulatory populations. We investigated the diagnostic power of electrocardiogram (ECG) and cardiac biomarker criteria to predict clinically relevant myocardial injury using benchmarks of mortality and increased hospital length of stay (HLOS) in patients undergoing coronary artery bypass graft (CABG) surgery.
  
  
  RESULTS
  Perioperative ECGs, creatinine kinase MB fraction, and cardiac troponin I (cTnI) were assessed in 545 primary CABG patients. None of the ECG criteria for myocardial injury predicted mortality or HLOS. However, post-operative day (POD) 1 cTnI levels independently predicted 5-year mortality (hazard ratio = 1.42; 95% CI 1.14-1.76 for each 10 microg/L increase; P = 0.009), while adjusting for baseline demographic characteristics and perioperative risk factors. Moreover, cTnI was the only biomarker that significantly improved the prediction of 5-year mortality estimated by the logistic Euroscore (P = 0.02). Furthermore, the predictive value of cTnI for 5-year mortality was replicated in a separately collected cohort of 1031 CABG patients using cardiac troponin T.
  
  
  CONCLUSIONS
  Electrocardiogram diagnosis of post-operative myocardial injury after CABG does not independently predict an increased risk of 5-year mortality or HLOS. Conversely, cTnI is independently associated with an increased risk of mortality and prolonged HLOS.
authors.affiliation: Department of Anaesthesiology, Perioperative and Pain Medicine, CWN L1, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. jmuehlschlegel@partners.org
authors.forename: Jochen D
authors.initials: JD
authors.lastname: Muehlschlegel
authors.forename: Tjörvi E
authors.initials: TE
authors.lastname: Perry
authors.forename: Kuang-Yu
authors.initials: KY
authors.lastname: Liu
authors.forename: Luigino
authors.initials: L
authors.lastname: Nascimben
authors.forename: Amanda A
authors.initials: AA
authors.lastname: Fox
authors.forename: Charles D
authors.initials: CD
authors.lastname: Collard
authors.forename: Edwin G
authors.initials: EG
authors.lastname: Avery
authors.forename: Sary F
authors.initials: SF
authors.lastname: Aranki
authors.forename: Michael N
authors.initials: MN
authors.lastname: D'Ambra
authors.forename: Stanton K
authors.initials: SK
authors.lastname: Shernan
authors.forename: Simon C
authors.initials: SC
authors.lastname: Body
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D004796:Clinical Enzyme Tests; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D052279:Creatine Kinase, MB Form / Q000097:blood*; D004562:Electrocardiography / Q000379:methods; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000209:etiology; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I; D052279:Creatine Kinase, MB Form