title: Versatility of choline metabolism and choline-binding proteins in Streptococcus pneumoniae and commensal streptococci.
abstract: The pneumococcal choline-containing teichoic acids are targeted by cholinebinding proteins (CBPs), major surface components implicated in the interaction with host cells and bacterial cell physiology. CBPs also occur in closely related commensal species, Streptococcus oralis and Streptococcus mitis, and many strains of these species contain choline in their cell wall. Physiologically relevant CBPs including cell wall lytic enzymes are highly conserved between Streptococcus pneumoniae and S. mitis. In contrast, the virulence-associated CBPs, CbpA, PspA and PcpA, are S. pneumoniae specific and are thus relevant for the characteristic properties of this species.
authors.affiliation: Department of Microbiology, University of Kaiserslautern, Germany. hakenb@rhrk.uni-kl.de
authors.forename: Regine
authors.initials: R
authors.lastname: Hakenbeck
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Madhour
authors.forename: Dalia
authors.initials: D
authors.lastname: Denapaite
authors.forename: Reinhold
authors.initials: R
authors.lastname: Brückner
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D002794:Choline / Q000378:metabolism*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D014644:Genetic Variation; D008969:Molecular Sequence Data; D011485:Protein Binding; D017422:Sequence Analysis, DNA; D034361:Streptococcus mitis / Q000235:genetics* / Q000378:metabolism; D019533:Streptococcus oralis / Q000235:genetics* / Q000378:metabolism; D013296:Streptococcus pneumoniae / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D002794:Choline