Impaired semantic inhibition during lexical ambiguity repetition in Parkinson's disease.
Impairments of semantic processing and inhibition have been observed in Parkinson's disease (PD), however, the consequences of faulty meaning selection and suppression have not been considered in terms of subsequent lexical processing. The present study employed a lexical ambiguity repetition paradigm where the first presentation of an ambiguity paired with a target biasing its dominant or subordinate meaning (e.g., bank - money or bank - river) was followed after several intervening trials by a presentation of the same ambiguity paired with a different target that biases the same (congruent) or a different (incongruent) meaning to that biased on the first presentation. Meaning dominance (dominant or subordinate weaker meanings) and interstimulus interval (ISI) were manipulated. Analyses conducted on the second presentation indicated priming of congruent meanings and no priming for the incongruent meanings at both short and long ISIs in the healthy controls, consistent with suppression of meanings competing with the representation biased in the first presentation. In contrast, the PD group failed to dampen activation for the incongruent meaning at the long ISI when the first presentation was subordinate. This pattern is consistent with an impairment of meaning suppression which is observed under controlled processing conditions and varies as a function of meaning dominance of the first presentation. These findings further refine our understanding of lexical-semantic impairments in PD and suggest a mechanism that may contribute to discourse comprehension impairments in this population.
Copland
David A
DA
The University of Queensland, Language Neuroscience Laboratory, Centre for Clinical Research & School of Health and Rehabilitation Sciences, Brisbane, Australia. d.copland@uq.edu.au
Sefe
Gameli
G
Ashley
Jane
J
Hudson
Carrie
C
Chenery
Helen J
HJ
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003071:Cognition; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000523:psychology*; D011930:Reaction Time; D012660:Semantics; D013647:Task Performance and Analysis; D013997:Time Factors