title: Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel.
abstract: Aryl sulfonamido tetralins based on lead compound 2a were synthesized and evaluated for Kv1.5 inhibitory activity. Several compounds having IC(50) values less then 0.1 microM were identified. Kv1.5 inhibitors have the potential to be atrium-selective agents for the treatment of atrial fibrillation.
authors.affiliation: Icagen Inc, NC 27709, United States.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Gross
authors.forename: Neil A
authors.initials: NA
authors.lastname: Castle
authors.forename: Anruo
authors.initials: A
authors.lastname: Zou
authors.forename: Alan D
authors.initials: AD
authors.lastname: Wickenden
authors.forename: Weifeng
authors.initials: W
authors.lastname: Yu
authors.forename: Kerry L
authors.initials: KL
authors.lastname: Spear
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D051666:Kv1.5 Potassium Channel / Q000037:antagonists & inhibitors* / Q000378:metabolism; D026902:Potassium Channel Blockers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D051666:Kv1.5 Potassium Channel; D026902:Potassium Channel Blockers; D013449:Sulfonamides; D013764:Tetrahydronaphthalenes