[Consensus clinical practice guidelines of the Andalusian Epilepsy Society: therapeutic recommendations when dealing with a first epileptic seizure and in epileptic status].
BACKGROUND
Most epileptic seizures are brief and self-limiting, but sometimes they can last longer than expected and this entails (in the case of generalised seizures) a high risk of morbidity and mortality, which increases as they get longer. This severity justifies the need to draw up a set of consensus-based practice guidelines based on implicit evidence, to use Liberati's nomenclature, concerning aspects related to the recommended therapeutic management of a patient with prolonged seizures who is being attended in an emergency department.


METHODS
A selective search was conducted on PubMed-Medline for scientific information related to the subject using scientific evidence filters. This search was completed in other scientific evidence search engines, such as Tripdatabase, Biblioteca Cochrane Plus or DARE. The selected references were analysed and discussed by the authors, and the available evidence and any recommendations that could be drawn from it were collected.


RESULTS
The search revealed the existence of 33 primary documents and six practice guidelines or protocols related with the topic under study. The recommendations were inserted in the text explicitly.


CONCLUSIONS
The therapeutic protocol must be started when faced with any seizures that last more than five minutes. First, steps must be taken to ensure proper respiratory and cardiocirculatory functioning, and then fast-acting antiepileptic drugs are administered intravenously and in high doses until the cause is identified and controlled. Due to their lower level of morbidity and mortality, prolonged non-convulsive seizures do not generally require therapy that is so vigorous and with such a high risk of complications.
Mercadé-Cerda
J M
JM
Hospital Universitario Carlos Haya, Malaga, Espana. juanmercade@gmail.com
Sánchez-Alvarez
J C
JC
Galán-Barranco
J M
JM
Moreno-Alegre
V
V
Serrano-Castro
P J
PJ
Cañadillas-Hidalgo
F M
FM
D006801:Humans; D000927:Anticonvulsants / Q000627:therapeutic use; D016208:Databases, Factual; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology; D019317:Evidence-Based Medicine; D013030:Spain; D016896:Treatment Outcome
D000927:Anticonvulsants