Dry eye in 2008.
OBJECTIVE
Although researchers continue to investigate the multifarious etiologic, anatomical, physiological, and pathological factors of dry eye, successful treatment remains a challenge.


RESULTS
Dry eye prevalence is substantial across populations and the term 'dry eye' is used to describe numerous causes and varied pathophysiologies. Advanced study of the physiological aspects of the ocular anatomy (e.g. cornea and conjunctiva, tear film, eyelids) allows improved understanding of the mechanisms involved in dry eye and the impact of different causes on these entities. Sophisticated diagnostics are being developed to efficiently identify dry eye. Management options include a variety of novel agents in the pipeline.


CONCLUSIONS
The development of improved etiological understanding and diagnostics for dry eye, as well as emerging therapeutics, will likely allow targeted therapy in the future.
Abelson
Mark B
MB
Ora, Andover, MA 01810, USA. mark.abelson@schepens.harvard.edu
Ousler
George W
GW
Maffei
Ciera
C
D000367:Age Factors; D000869:Anterior Eye Segment / Q000503:physiopathology; D002940:Circadian Rhythm; D016207:Cytokines / Q000502:physiology; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D005143:Eyelids / Q000503:physiopathology; D006801:Humans; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D012737:Sex Factors; D013666:Tears / Q000502:physiology
D016207:Cytokines; D009883:Ophthalmic Solutions