Who's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior.
Steroid hormones act in brain and throughout the body to regulate a variety of functions, including development, reproduction, stress and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which are members of the steroid/nuclear receptor superfamily of transcriptional activators. A variety of studies in cell lines reveal that nuclear receptor coregulators are critical in modulating steroid receptor-dependent transcription. Thus, in addition to the availability of the hormone and the expression of its receptor, nuclear receptor coregulators are essential for efficient steroid-dependent transactivation of genes. This review will highlight the importance of nuclear receptor coregulators in modulating steroid-dependent gene expression in brain and the regulation of behavior.
Tetel
Marc J
MJ
Neuroscience Program, Wellesley College, 106 Central St., Wellesley, MA 02481, USA. mtetel@wellesley.edu
Auger
Anthony P
AP
Charlier
Thierry D
TD
D000818:Animals; D001519:Behavior / Q000502:physiology*; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism / Q000502:physiology*; D012097:Repressor Proteins / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*; D015533:Transcriptional Activation / Q000502:physiology
D018160:Receptors, Cytoplasmic and Nuclear; D012097:Repressor Proteins; D015534:Trans-Activators