Epithelial polarity: dual Lkb1 pathways regulate apical microvilli.
The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. In this issue of Developmental Cell, ten Klooster et al. show that the Lkb1/Strad/Mo25 complex mediates two separate pathways, and that both are required for assembly of apical microvilli.
Bretscher
Anthony
A
Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA. apb5@cornell.edu
D000091162:AMP-Activated Protein Kinase Kinases; D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism; D016764:Cell Polarity; D004847:Epithelial Cells / Q000166:cytology* / Q000201:enzymology*; D006801:Humans; D008871:Microvilli / Q000201:enzymology* / Q000648:ultrastructure; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D000099317:Hippo Kinases
D000091162:AMP-Activated Protein Kinase Kinases; D033942:Adaptor Proteins, Vesicular Transport; D017346:Protein Serine-Threonine Kinases; C476400:STRADA protein, human; C430908:STK26 protein, human; D000099317:Hippo Kinases; C109790:STK11 protein, human