title: Correlation of histopathological diagnosis with habits and clinical findings in oral submucous fibrosis.
abstract: BACKGROUND
  Oral submucous fibrosis is a common oral health problem in India. This study was conducted to correlate the histopathological diagnosis with habits and clinical findings in patients suffering from oral submucous fibrosis (OSF).
  
  
  METHODS
  Patients suffering from oral submucous fibrosis from the Departments of Otorhinolaryngology and Pathology, Moti Lal Nehru Medical College, Allahabad, India were studied from 2004-2008. Detailed information was gathered in a pretested proforma. Emphasis was given to the various addictions, clinical findings and histological examination was done.
  
  
  RESULTS
  Two hundred and thirty nine patients were studied, yielding a male to female ratio of 6.8:1. Maximum patients were in the 21-30 years age group with a marked male predominance. Of these, 197 (82.4%) patients chewed areca nut/dohra, 14 (5.8%) were smokers and 2 (0.8%) patients were habituated to alcohol. 89 (37.2%) patients reported difficulty in opening of the mouth (trismus). 51 (57.4%) patients were found to have stage II (2-3 cm) trismus while rest had stage I and III. The buccal mucosa was found to be the most commonly involved site. On the basis of histopathological examination, 52 (21.7%) were classified as OSF grade I, 75 (31.3%) patients as grade II and 112 (46.8%) had grade III disease.
  
  
  CONCLUSIONS
  The widespread habit of chewing dohra/paan masala is a major risk factor of OSF, especially in the younger age group. In this study, an increase in histopathological grading was found with severity and duration of addiction habit. However no significant correlation was found between clinical staging and histopathological grading.
authors.affiliation: Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India. shrutigentech@gmail.com
authors.forename: Shruti
authors.initials: S
authors.lastname: Pandya
authors.forename: Ajay Kumar
authors.initials: AK
authors.lastname: Chaudhary
authors.forename: Mamta
authors.initials: M
authors.lastname: Singh
authors.forename: Mangal
authors.initials: M
authors.lastname: Singh
authors.forename: Ravi
authors.initials: R
authors.lastname: Mehrotra
mesh_terms: D000328:Adult; D000368:Aged; D001114:Areca / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009914:Oral Submucous Fibrosis / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects