[Airways inflammation evaluation. Upper and lower airways].
It is done a review of evaluation methods of the inflammation in upper airways and bronchi used for diagnosis, therapeutic approach and prognosis of pathologies like rhinosinusitis and asthma. It is also analysed methods that supply relevant information of inflammation in COPD. The chronic inflammation of the airways is associated to respiratory distress, obstruction in basal lung function tests and to bronchial and nasal hyperreactivity. Computerized tomography informs about lumen dimensions, bronchial walls thickness and pulmonary density. These changes are associated to inflammation and to remodelling of the airways. Localized inflammation in respiratory tract can be detected by modifications of systemic inflammatory markers. The direct evaluation of inflammatory airways changes are based on immune, histological and chemical analysis of lung tissue obtained by biopsies and by fluids recoil in basal conditions or after stimulation. The eosinophils are increased in biopsies and in nasal and bronchoalveolar lavage in asthma and rhinitis and can change with therapy. Proteins and mRNA expression of cellular activation mediators are also observed. The induced sputum identifies eosinophilic inflammation that is inversely associated with lung function parameters. In each respiratory cycle the air is enriched in organic volatile compounds produced by cellular breathing. FENO is the bio marker more deeply studied in asthma and its increase is well documented in this disorder. In the exhaled air condensed, reactive oxygen species, membrane mediators, cytokines, and chemokines are identified. If the non invasive evaluation of inflammation became reliable and reproducible it will be indispensable in monitoring the airways diseases.
Geraldes
Luísa
L
Serviço de Imunoalergologia, Departamento de Ciências Pneumológicas e Alergológicas dos Hospitais da Universidade de Coimbra, Coimbra.
Todo-Bom
Ana
A
Loureiro
Carlos
C
D001249:Asthma / Q000175:diagnosis; D001944:Breath Tests; D016535:Bronchial Hyperreactivity / Q000175:diagnosis; D001991:Bronchitis / Q000175:diagnosis; D001992:Bronchoalveolar Lavage Fluid; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis; D012220:Rhinitis / Q000175:diagnosis; D012852:Sinusitis / Q000175:diagnosis