title: Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age.
abstract: BACKGROUND
  Asthma may be more prevalent in overweight children. However, how early overweight and changes in weight status during childhood affect the asthma risk is unclear.
  
  
  OBJECTIVE
  To investigate overweight and changes in overweight status in children age 1 to 8 years in relation to asthma symptoms in childhood.
  
  
  METHODS
  We studied 3756 children who participated in a large birth cohort study. The parents reported their children's weight and height, and wheeze, dyspnea, and prescription of inhaled corticosteroids in yearly questionnaires. Sensitization to inhalant allergens and bronchial hyperresponsiveness (BHR) were determined at 8 years.
  
  
  RESULTS
  At 8 years, 275 children (7.3%) wheezed, 361 (9.6%) had dyspnea, and 268 (7.1%) had a prescription of inhaled corticosteroids in the preceding year. Children who had a persistent high body mass index (BMI, weight/height2) during childhood or a high BMI at 6 to 7 years had a significantly increased risk of dyspnea (adjusted odds ratio, 1.68; 95% CI, 1.18-2.39, for a high BMI at 6-7 years) and measured BHR (adjusted odds ratio, 1.66; 95% CI, 1.10-2.52) at 8 years. Children with a high BMI at a young age, but who developed a normal BMI at 6 to 7 years, did not have an increased risk of dyspnea or BHR at 8 years. BMI was not associated with sensitization.
  
  
  CONCLUSIONS
  Children with a current high BMI are at increased risk to have dyspnea and BHR at 8 years. A high BMI at an earlier age is not related to an increased risk if the child has become normal weight at 6 to 7 years.
authors.affiliation: Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. salome.scholtens@rivm.nl
authors.forename: Salome
authors.initials: S
authors.lastname: Scholtens
authors.forename: Alet H
authors.initials: AH
authors.lastname: Wijga
authors.forename: Jacob C
authors.initials: JC
authors.lastname: Seidell
authors.forename: Bert
authors.initials: B
authors.lastname: Brunekreef
authors.forename: Johan C
authors.initials: JC
authors.lastname: de Jongste
authors.forename: Ulrike
authors.initials: U
authors.lastname: Gehring
authors.forename: Dirkje S
authors.initials: DS
authors.lastname: Postma
authors.forename: Marjan
authors.initials: M
authors.lastname: Kerkhof
authors.forename: Henriette A
authors.initials: HA
authors.lastname: Smit
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004417:Dyspnea / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D050177:Overweight / Q000150:complications*; D015995:Prevalence; D012135:Respiratory Sounds / Q000276:immunology; D011795:Surveys and Questionnaires
chemical_list: D000305:Adrenal Cortex Hormones; D000485:Allergens; D007073:Immunoglobulin E