title: Copper-free "click" modification of DNA via nitrile oxide-norbornene 1,3-dipolar cycloaddition.
abstract: Nitrile oxides react smoothly and rapidly with norbornene-modified DNA in a copper-free click reaction. The reaction allows high density functionalization of oligodeoxyribonucleotides (ODNs) with a large variety of molecules directly on solid supports and even in synthesizers without the need for an additional catalyst.
authors.affiliation: Center for Integrative Protein Science at the Department of Chemistry and Biochemistry, Ludwig Maximilians University, Butenandtstr 5-13, 81377 Munich.
authors.forename: Katrin
authors.initials: K
authors.lastname: Gutsmiedl
authors.forename: Christian T
authors.initials: CT
authors.lastname: Wirges
authors.forename: Veronika
authors.initials: V
authors.lastname: Ehmke
authors.forename: Thomas
authors.initials: T
authors.lastname: Carell
mesh_terms: D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009636:Norbornanes / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*
chemical_list: D009570:Nitriles; D009636:Norbornanes; D009838:Oligodeoxyribonucleotides; D010087:Oxides; D004247:DNA