title: Prevalence of mef and ermB genes in invasive pediatric erythromycin-resistant Streptococcus pneumoniae isolates from Argentina.
abstract: During the period 1993-2001, a total of 1,499 pneumococci isolates were recovered through the Argentinean surveillance of Streptococcus pneumoniae causing invasive disease in children under 6 years of age, 3.5% of which were erythromycin resistant. Among the 50 erythromycin-resistant strains available, 58% (n=29) harbored mefA/E genes (15 mefA, 30%; and 14 mefE, 28%), 34% (n=17) ermB, and 6% (n=3) both mefA/E plus ermB genes, while one isolate was negative for all the acquired genes studied. The England14-9 (42%), Poland6B-20 (20%) and Spain9V-3 (16%) clones were responsible for the emergence of pneumococcal macrolide resistance in pediatric population from Argentina.
authors.affiliation: Servicio Antimicrobianos, Departamento Bacteriología, INEI-ANLIS Dr. Carlos G. Malbrán, Av. Vélez Sarsfield 563, (1281), Ciudad Autónoma de Buenos Aires, Argentina. acorso@anlis.gov.ar
authors.forename: A
authors.initials: A
authors.lastname: Corso
authors.forename: D
authors.initials: D
authors.lastname: Faccone
authors.forename: P
authors.initials: P
authors.lastname: Gagetti
authors.forename: J
authors.initials: J
authors.lastname: Pace
authors.forename: M
authors.initials: M
authors.lastname: Regueira
authors.forename: Julio
authors.initials: J
authors.lastname: Pace
mesh_terms: D001118:Argentina / Q000453:epidemiology; D001426:Bacterial Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002999:Clone Cells; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004917:Erythromycin / Q000494:pharmacology*; D005798:Genes, Bacterial; D006801:Humans; D007223:Infant; D008565:Membrane Proteins / Q000235:genetics*; D008780:Methyltransferases / Q000235:genetics*; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D001426:Bacterial Proteins; C117866:MefA protein, Streptococcus; D008565:Membrane Proteins; D004917:Erythromycin; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase