title: Bisphosphonates in periodontal treatment: a review.
abstract: Periodontitis is a multifactorial disease involving bacterial biofilms and the generation of an inflammatory response. The latter causes the major part of the periodontal tissue breakdown. Alveolar bone resorption is a major component of the periodontal destruction observed in periodontitis. Novel treatment modalities of periodontitis intend to control and modulate the host response to bacterial aggression. Drugs such as bisphosphonates (BPs) are proven antiresorptive agents that can potentially inhibit the alveolar bone resorption. This review describes the potential use of BPs in periodontal treatment and could be said that BPs have an in vitro and in vivo capability of reducing bone resorption. Only a few studies have been carried out on the improvement of clinical periodontal parameters after the administration of BPs. Therefore, the published data are not sufficient to establish an evidence-based relevance for the use of these drugs in the treatment of periodontal diseases.
authors.affiliation: Department of Periodontology-ERT 2004, School of Dental Surgery, University of Nantes, Nantes, France.
authors.forename: Zahi
authors.initials: Z
authors.lastname: Badran
authors.forename: Michael Alexander
authors.initials: MA
authors.lastname: Kraehenmann
authors.forename: Jérôme
authors.initials: J
authors.lastname: Guicheux
authors.forename: Assem
authors.initials: A
authors.lastname: Soueidan
mesh_terms: D016301:Alveolar Bone Loss / Q000517:prevention & control; D000818:Animals; D050071:Bone Density Conservation Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004164:Diphosphonates / Q000009:adverse effects / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D010010:Osteoclasts / Q000187:drug effects; D010518:Periodontitis / Q000628:therapy*
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D004791:Enzyme Inhibitors