Clavatadines C-E, guanidine alkaloids from the Australian sponge Suberea clavata.
Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds aerophobin 1 (4), purealdin L (5), and aplysinamisine II (6) were isolated from extracts of the sponge Suberea clavata by bioassay-guided fractionation using a serine protease factor XIa assay. Their structures were determined by 1D and 2D NMR spectroscopy. Compounds 1-6 exhibited weak inhibition of factor XIa.
Buchanan
Malcolm S
MS
Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
Carroll
Anthony R
AR
Wessling
Deborah
D
Jobling
Michael
M
Avery
Vicky M
VM
Davis
Rohan A
RA
Feng
Yunjiang
Y
Hooper
John N A
JN
Quinn
Ronald J
RJ
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001315:Australia; D015945:Factor XIa / Q000037:antagonists & inhibitors; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
D000470:Alkaloids; D006146:Guanidines; C550884:clavatadine C; C550885:clavatadine D; C550886:clavatadine E; D015945:Factor XIa