[Hypertension, HIV infection, and highly active antiretroviral therapy].
The decline in mortality resulting from the use of highly active antiretroviral therapy (HAART) has been accompanied by an increase in metabolic complications that produce accelerated atherosclerosis. Hypertension is one of the most important cardiovascular risk factors. Little is known about the impact of HAART on blood pressure, and it is uncertain whether chronic HIV infection or HAART have a role in the development of hypertension. In this study, the research on the relationships between hypertension and HIV infection published to date is reviewed. Antiretroviral therapy appears to have a modest impact on blood pressure and to be partially mediated by the metabolic changes occurring with this treatment.
Bernardino de la Serna
José Ignacio
JI
Unidad VIH, Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, España. jibernardino.hulp@salud.madrid.org
Zamora
Francisco Xavier
FX
Montes
María Luisa
ML
García-Puig
Juan
J
Arribas
José Ramón
JR
D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000494:pharmacology; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D050197:Atherosclerosis / Q000209:etiology / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D015331:Cohort Studies; D050171:Dyslipidemias / Q000139:chemically induced / Q000150:complications; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D007333:Insulin Resistance; D007674:Kidney Diseases / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced; D008875:Middle Aged; D008954:Models, Biological; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors