title: Palladium-catalyzed asymmetric dearomatization of naphthalene derivatives.
abstract: An intramolecular enantioselective metal-catalyzed dearomatization reaction is described. This procedure allows the dearomatization of naphthalene derivatives through an electrophilic aromatic substitution-type reaction on a Pd(II) intermediate. The high yields and enantioselectivities achieved make this procedure a valuable method for synthetic chemists.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Jorge
authors.initials: J
authors.lastname: García-Fortanet
authors.forename: Florian
authors.initials: F
authors.lastname: Kessler
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D002227:Carbazoles / Q000138:chemical synthesis; D002384:Catalysis; D009281:Naphthalenes / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002227:Carbazoles; D009281:Naphthalenes; D010165:Palladium