Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation.
Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.
Oudshoorn
Christian
C
Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
van der Cammen
Tischa J M
TJ
McMurdo
Marion E T
ME
van Leeuwen
Johannes P T M
JP
Colin
Edgar M
EM
D000368:Aged; D000375:Aging / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D019587:Dietary Supplements; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism; D014807:Vitamin D / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000378:metabolism*
D010281:Parathyroid Hormone; D014807:Vitamin D; D002118:Calcium