title: A fully automated algorithm under modified FCM framework for improved brain MR image segmentation.
abstract: Automated brain magnetic resonance image (MRI) segmentation is a complex problem especially if accompanied by quality depreciating factors such as intensity inhomogeneity and noise. This article presents a new algorithm for automated segmentation of both normal and diseased brain MRI. An entropy driven homomorphic filtering technique has been employed in this work to remove the bias field. The initial cluster centers are estimated using a proposed algorithm called histogram-based local peak merger using adaptive window. Subsequently, a modified fuzzy c-mean (MFCM) technique using the neighborhood pixel considerations is applied. Finally, a new technique called neighborhood-based membership ambiguity correction (NMAC) has been used for smoothing the boundaries between different tissue classes as well as to remove small pixel level noise, which appear as misclassified pixels even after the MFCM approach. NMAC leads to much sharper boundaries between tissues and, hence, has been found to be highly effective in prominently estimating the tissue and tumor areas in a brain MR scan. The algorithm has been validated against MFCM and FMRIB software library using MRI scans from BrainWeb. Superior results to those achieved with MFCM technique have been observed along with the collateral advantages of fully automatic segmentation, faster computation and faster convergence of the objective function.
authors.affiliation: Department of Electronics and Communication Engineering, Indian Institute of Technology Guwahati, India. k.sikka@iitg.ernet.in
authors.forename: Karan
authors.initials: K
authors.lastname: Sikka
authors.forename: Nitesh
authors.initials: N
authors.lastname: Sinha
authors.forename: Pankaj K
authors.initials: PK
authors.lastname: Singh
authors.forename: Amit K
authors.initials: AK
authors.lastname: Mishra
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000033:anatomy & histology*; D016000:Cluster Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity