title: Advanced malignant minor salivary glands tumors of the oral cavity.
abstract: OBJECTIVE
  Intraoral minor salivary gland carcinomas (MSGC) are rare tumors with different frequency, distribution, and prognostic factors relating to overall survival.
  
  
  METHODS
  From 1992 to 2006, a total of 95 patients with MSGC originating in the oral cavity were analyzed by univariate and multivariate analysis using the log-rank test and Cox-regression.
  
  
  RESULTS
  Fifty-four percent of all patients had a low-grade disease and 46% had a high grade disease. The 2-, 5-, and 10-year overall survivals were 82%, 73%, and 58%, respectively. The T (P = .007), N category (P = .010), UICC stage (P = .021), and resection margin status (P < .0001) statistically influenced survival, whereas the M status did not (P = .16). Salvage treatment influenced the patients' overall survival significantly (P < .0001).
  
  
  CONCLUSIONS
  This study confirms that in MSGC salvage surgery and tumor stage correlates well with prognosis. More studies are necessary to confirm prognostic factors and determine the true frequency of MSGC in the oral cavity.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, München, Germany. th.mucke@gmx.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Mücke
authors.forename: Luisa Katharina
authors.initials: LK
authors.lastname: Robitzky
authors.forename: Marco Rainer
authors.initials: MR
authors.lastname: Kesting
authors.forename: Stefan
authors.initials: S
authors.lastname: Wagenpfeil
authors.forename: Bettina
authors.initials: B
authors.lastname: Holhweg-Majert
authors.forename: Klaus-Dietrich
authors.initials: KD
authors.lastname: Wolff
authors.forename: Frank
authors.initials: F
authors.lastname: Hölzle
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000556:secondary; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology / Q000556:secondary; D003528:Carcinoma, Adenoid Cystic / Q000453:epidemiology / Q000556:secondary; D018277:Carcinoma, Mucoepidermoid / Q000453:epidemiology / Q000556:secondary; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D010157:Palatal Neoplasms / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000453:epidemiology* / Q000473:pathology; D012470:Salivary Glands, Minor / Q000473:pathology*; D016879:Salvage Therapy; D012737:Sex Factors; D015996:Survival Rate; D016896:Treatment Outcome