title: Effects of nanomaterial physicochemical properties on in vivo toxicity.
abstract: It is well recognized that physical and chemical properties of materials can alter dramatically at nanoscopic scale, and the growing use of nanotechnologies requires careful assessment of unexpected toxicities and biological interactions. However, most in vivo toxicity concerns focus primarily on pulmonary, oral, and dermal exposures to ultrafine particles. As nanomaterials expand as therapeutics and as diagnostic tools, parenteral administration of engineered nanomaterials should also be recognized as a critical aspect for toxicity consideration. Due to the complex nature of nanomaterials, conflicting studies have led to different views of their safety. Here, the physicochemical properties of four representative nanomaterials (dendrimers, carbon nanotubes, quantum dots, and gold nanoparticles) as it relates to their toxicity after systemic exposure is discussed.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.
authors.forename: Kristin L
authors.initials: KL
authors.lastname: Aillon
authors.forename: Yumei
authors.initials: Y
authors.lastname: Xie
authors.forename: Nashwa
authors.initials: N
authors.lastname: El-Gendy
authors.forename: Cory J
authors.initials: CJ
authors.lastname: Berkland
authors.forename: M Laird
authors.initials: ML
authors.lastname: Forrest
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity*; D037742:Nanotubes, Carbon / Q000737:chemistry / Q000633:toxicity; D045663:Quantum Dots
chemical_list: D050091:Dendrimers; D037742:Nanotubes, Carbon