title: The role of rehabilitation in deep brain stimulation of the subthalamic nucleus for Parkinson's disease: a pilot study.
abstract: Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an efficacious therapeutic option in the treatment of advanced Parkinson's disease (PD). The procedure may be however associated with functional impairment of different types and intensity. In this paper we describe the functional impairments detected in a group of 34 subjects with PD who were submitted to DBS. These patients belonged to a cohort of 75 consecutive PD patients who underwent the surgical procedure. The rehabilitation program included physiotherapy exercises for recovery/maintenance of the range of motion, active exercises, exercises for coordination and proprioception, and walking training based on the use of sensory cues, with daily sessions for a period of 4-8 weeks. The motor examination section of unified Parkinson's disease rating scale (UPDRS-ME) and the functional independence measure (FIM) scores showed a consistent and significant improvement in the patients' motor performances. The reported findings suggest that rehabilitation may play an important role in the correction of specific functional impairments caused by or associated with DBS in PD.
authors.affiliation: Department of Neurological Sciences, Interdepartmental Centre of Research on Parkinson's Disease (ICRPD), IRCCS C. Mondino Institute of Neurology Foundation, University of Pavia, Via Mondino 2, 27100 Pavia, Italy. cristina.tassorelli@mondino.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Tassorelli
authors.forename: Simona
authors.initials: S
authors.lastname: Buscone
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sandrini
authors.forename: Claudio
authors.initials: C
authors.lastname: Pacchetti
authors.forename: Anna
authors.initials: A
authors.lastname: Furnari
authors.forename: Roberta
authors.initials: R
authors.lastname: Zangaglia
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Bartolo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nappi
authors.forename: Emilia
authors.initials: E
authors.lastname: Martignoni
mesh_terms: D003072:Cognition Disorders / Q000209:etiology / Q000534:rehabilitation; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D003680:Deglutition Disorders / Q000209:etiology / Q000534:rehabilitation; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology / Q000534:rehabilitation; D010146:Pain / Q000209:etiology / Q000534:rehabilitation; D010300:Parkinson Disease / Q000534:rehabilitation* / Q000628:therapy*; D010865:Pilot Projects; D004856:Postural Balance; D013064:Speech Disorders / Q000209:etiology / Q000534:rehabilitation; D020531:Subthalamic Nucleus / Q000502:physiology*