title: Antioxidants intake and dry eye syndrome: a crossover, placebo-controlled, randomized trial.
abstract: To assess whether an orally administered antioxidant dietary supplement could improve the objective clinical signs and alleviate the subjective symptoms of dry eye syndrome.
  
  
  
  Twenty-four subjects diagnosed with dry eye syndrome were randomized in a crossover, double-blind, controlled, randomized study to receive a placebo or an antioxidants combination (Oxybiane) for 12 weeks. In all subjects, break-up time (BUT) test, Schirmer test, ocular symptoms (sore eyes, burning, itching, sensation of foreign object in the eye, photophobia, sticky eyes, and redness), visual comfort, and general well-being were evaluated weekly.
  
  
  
  After 12 weeks of supplementation with Oxybiane, both the BUT scores (27.3%+/-8.4% with Oxybiane versus 3.61%+/-4.3% with the placebo, p=0.017) and the Schirmer scores (26.9%+/-14.2% with Oxybiane versus -4.7%+/-3.4% with the placebo, p=0.037) were significantly increased. A significantly improvement was also observed considering subjective clinical symptoms such as burning (p=0.031), itching (p=0.027), sensation of foreign body in eye (p=0.030), and redness (p=0.043). CONCLUSIONS. Supplementation with oral antioxidants can improve both tear stability and quantity but also subjective clinical signs.
authors.affiliation: PiLeJe, Paris - France. s.holowacz@pileje.com
authors.forename: Sophie
authors.initials: S
authors.lastname: Drouault-Holowacz
authors.forename: Séverine
authors.initials: S
authors.lastname: Bieuvelet
authors.forename: André
authors.initials: A
authors.lastname: Burckel
authors.forename: Danièle
authors.initials: D
authors.lastname: Rigal
authors.forename: Claude
authors.initials: C
authors.lastname: Dubray
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Lichon
authors.forename: Paul
authors.initials: P
authors.lastname: Bringer
authors.forename: Francois
authors.initials: F
authors.lastname: Pilon
authors.forename: Frédéric
authors.initials: FR
authors.lastname: Chiambaretta
mesh_terms: D000284:Administration, Oral; D000975:Antioxidants / Q000008:administration & dosage*; D002214:Capsules; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013666:Tears / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D002214:Capsules