title: Using K-minimum increment of diversity to predict secretory proteins of malaria parasite based on groupings of amino acids.
abstract: Due to the complexity of Plasmodium falciparumis genome, predicting secretory proteins of P. falciparum is more difficult than other species. In this study, based on the measure of diversity definition, a new K-nearest neighbor method, K-minimum increment of diversity (K-MID), is introduced to predict secretory proteins. The prediction performance of the K-MID by using amino acids composition as the only input vector achieves 88.89% accuracy with 0.78 Mathew's correlation coefficient (MCC). Further, the several reduced amino acids alphabets are applied to predict secretory proteins and the results show that the prediction results are improved to 90.67% accuracy with 0.83 MCC by using the 169 dipeptide compositions of the reduced amino acids alphabets obtained from Protein Blocks method.
authors.affiliation: Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University, 010021 Hohhot, China.
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Zuo
authors.forename: Qian-Zhong
authors.initials: QZ
authors.lastname: Li
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry* / Q000145:classification; D001185:Artificial Intelligence; D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D004151:Dipeptides / Q000737:chemistry; D014644:Genetic Variation; D017780:Malaria Vaccines / Q000276:immunology; D008954:Models, Biological; D010963:Plasmodium falciparum / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D015800:Protozoan Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism
chemical_list: D000596:Amino Acids; D004151:Dipeptides; D017780:Malaria Vaccines; D015800:Protozoan Proteins