title: Plasmodium fieldi: observations on the Hackeri and ABI strains in Macaca mulatta monkeys and mosquitoes.
abstract: Macaca mulatta monkeys infected with the Hackeri strain of Plasmodium fieldi had maximum parasite counts ranging from 1,300 to 301,320/microL. In 43 intact animals infected with the ABI strain, the maximum parasite counts ranged from 672 to 57,189/microL (median = 15,100/microL); in 46 splenectomized monkeys, the maximum parasite count ranged from 660 to 350,000/microL (median = 52,245/microL). Transmission through Anopheles dirus mosquitoes was obtained on 11 occasions with pre-patent periods of 9-14 days. Relapses occurred between two and eight times during a 1-year period. P. fieldi has potential for testing prophylactic and radical curative drugs.
authors.affiliation: Division of Parasitic Diseases and Scientific Resources Branch, National Center for Vector-Borne and Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, Georgia 30333, USA. wec1@cdc.gov
authors.forename: William E
authors.initials: WE
authors.lastname: Collins
authors.forename: Joann S
authors.initials: JS
authors.lastname: Sullivan
authors.forename: McWilson
authors.initials: M
authors.lastname: Warren
authors.forename: G Gale
authors.initials: GG
authors.lastname: Galland
authors.forename: Allison
authors.initials: A
authors.lastname: Williams
authors.forename: John W
authors.initials: JW
authors.lastname: Barnwell
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D000962:Antimalarials / Q000627:therapeutic use; D004195:Disease Models, Animal; D007303:Insect Vectors / Q000469:parasitology*; D008253:Macaca mulatta / Q000469:parasitology*; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology* / Q000635:transmission; D033661:Oocysts / Q000502:physiology; D010961:Plasmodium / Q000145:classification*; D013997:Time Factors
chemical_list: D000962:Antimalarials