title: Acute efficacy of combined therapy of carperitide and nicorandil for acute decompensated heart failure with left ventricular systolic dysfunction.
abstract: A 64-year-old woman was admitted to our hospital with acute decompensated heart failure (ADHF) and left ventricular systolic dysfunction. Initial treatment with carperitide (0.01 µg/kg/min) had little effect. Since she had a borderline systolic blood pressure (i.e., a systolic BP between 90 and 110 mm Hg) and atrial fibrillation with a rapid ventricular response, nicorandil (0.1 mg/kg/h) was added to carperitide. This combined therapy achieved rapid improvement of ADHF. To our knowledge, this is the first report of a patient with ADHF and borderline systolic blood pressure in whom the combination of carperitide and nicorandil was safe and effective.
authors.affiliation: Department of Cardiology, Shonan Dai-ichi Hospital, Kanagawa, Japan. Electronic address: kkajimoto@comet.ocn.ne.jp.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kajimoto
authors.affiliation: Department of Cardiology, Shonan Dai-ichi Hospital, Kanagawa, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Shimamura
mesh_terms: D000208:Acute Disease; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D020108:Nicorandil / Q000008:administration & dosage*; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: C472955:NPPA protein, human; D020108:Nicorandil; D009320:Atrial Natriuretic Factor