Estimation of diagnostic value of chosen markers of neural differentiation in neuroblastoma group of tumors and pPNETs.
Neuroblastoma and peripheral PNETs both are typical examples of wide group of small round blue cell tumors of childhood. Matured neuroblastoma show typical clinical presentation and easy to interpret microscopic picture. Unfortunately in everyday practice much commonly appeared less differentiated neuroblastomas with difficult to predict clinical behavior and impossible to diagnose in routine stain histologic view. Peripheral PNETs are found as morphologically similar entities to some neuroblastoma subtypes but they are treated as separate CD99 positive group of tumors with different biology and clinical behavior. The aim of our study was to estimate the usefulness of neural markers expression (Neuroblastoma Marker, neurospecyfic enolase and neurofilaments) in routine separation between neuroblastoma tumors and pPNETs and between neuroblastoma subtypes according to currently used classification of those entities. We investigated 63 tumor tissue samples and found differences in expression of investigated markers between both neuroblastoma subgroups and neuroblastoma group of tumors and pPNETs.
Sałacińska-Łoś
Elzbieta
E
Department of Pathology of the Age of Development, Konopnicka Memorial Hospital Medical University of Łódź.
Kobos
Józef
J
Taran
Katarzyna
K
D014408:Biomarkers, Tumor / Q000032:analysis*; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D009447:Neuroblastoma / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000378:metabolism
D014408:Biomarkers, Tumor