title: Is inflammatory bowel disease a risk factor for early atherosclerosis?
abstract: OBJECTIVE
  Chronic inflammatory diseases are associated with an accelerated atherosclerotic process. Recent studies have discussed whether inflammatory bowel diseases (IBDs) can predict early atherosclerosis. We investigated this possibility.
  
  
  METHODS
  The study consisted of IBD cases (group 1, n = 40) and healthy persons (group 2, n = 40). The IBD group was selected so as not to have vascular disease or the presence of established major cardiovascular risk factors.
  
  
  RESULTS
  Group 1 cases showed a significant increase in carotid intima media thickness (cIMT; P = .01). Carotid artery stiffness was impaired in group 1 (P = .03) and high-sensitivity C-reactive protein (hsCRP), homeostasis model assessment of insulin resistance (HOMA-IR), and homocysteine (Hyc) were higher in group 1 patients (P = .02, P = .03, P = .05).
  
  
  CONCLUSIONS
  Inflammatory bowel disease patients have an increased risk of early atherosclerosis as shown by greater values of cIMT, carotid artery stiffness, Hyc, hsCRP, and insulin resistance.
authors.affiliation: Department of Cardiology, First University, Medical School, Elaziğ, Turkey. mustafanecati46@hotmail.com
authors.forename: Necati
authors.initials: N
authors.lastname: Dagli
authors.forename: Orhan K
authors.initials: OK
authors.lastname: Poyrazoglu
authors.forename: A Ferda
authors.initials: AF
authors.lastname: Dagli
authors.forename: Fatih
authors.initials: F
authors.lastname: Sahbaz
authors.forename: Ilgin
authors.initials: I
authors.lastname: Karaca
authors.forename: M Ali
authors.initials: MA
authors.lastname: Kobat
authors.forename: Ibrahim H
authors.initials: IH
authors.lastname: Bahcecioglu
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D050197:Atherosclerosis / Q000453:epidemiology*; D002097:C-Reactive Protein / Q000032:analysis; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging; D015897:Comorbidity; D004548:Elasticity; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology* / Q000473:pathology; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D017539:Tunica Intima / Q000473:pathology; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D006710:Homocysteine; D002097:C-Reactive Protein