[Immunity in parasite-vector snails].
Aquatic snails play a key role in the transmission of parasites such as the human blood or liver flukes (Schistosomes and Fasciola sp.). During the last decade, particular efforts have been made by a small number of scientists to progress in our understanding of the molecular mechanisms underlying snail immune responses and/or host parasite interactions. Complementary approaches using the gastropod snail Biomphalaria glabrata, an intermediate host of Schistosoma mansoni, have yielded a number of unexpected results such as the existence of highly diversified pathogen-binding proteins (FREPs), or potential immune regulators similar to mammalian cytokines. Although molecular immune processes largely remain to be elucidated, accumulating data support the idea that snail innate immunity is much more complex than originally thought.
Coustau
Christine
C
U547 Inserm Schistosomiase, paludisme et inflammation, Institut Pasteur de Lille, 59019 Lille Cedex, France. christine.coustau@sophia.inra.fr
D000818:Animals; D001700:Biomphalaria / Q000235:genetics / Q000276:immunology / Q000469:parasitology*; D004199:Disease Vectors; D005209:Fasciola / Q000502:physiology; D020869:Gene Expression Profiling; D006434:Hemocytes / Q000502:physiology; D006790:Host-Parasite Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007136:Immunoglobulins / Q000502:physiology*; D007156:Immunologic Memory; D007814:Larva; D008018:Life Cycle Stages; D018448:Models, Immunological; D020543:Proteome; D012550:Schistosoma mansoni / Q000254:growth & development / Q000502:physiology*; D012552:Schistosomiasis / Q000469:parasitology / Q000635:transmission; D012908:Snails / Q000469:parasitology
D007136:Immunoglobulins; D020543:Proteome; C445539:fibrinogen-related protein 3, Biomphalaria glabrata