Monte Carlo modelling of the influence of boron microdistribution on BNCT microdosimetry.
The ion transport Monte Carlo code SRIM has been used to calculate single event lineal energy spectra for the products of the boron-neutron capture reaction in a water-based medium. The event spectra have been benchmarked against spectra measured with a boron-loaded tissue-equivalent proportional counter (TEPC). Agreement is excellent and supports the use of Monte Carlo methods in understanding the influence of boron delivery on the effectiveness of boron-neutron capture therapy (BNCT).
Hugtenburg
Richard P
RP
School of Medicine, Swansea University, UK. r.p.hugtenburg@swansea.ac.uk
Baker
Adam E R
AE
Green
Stuart
S
D001895:Boron / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000706:statistics & numerical data*; D006371:Helium / Q000528:radiation effects; D006801:Humans; D018499:Linear Energy Transfer; D008094:Lithium / Q000528:radiation effects; D009010:Monte Carlo Method; D009369:Neoplasms / Q000378:metabolism / Q000532:radiotherapy; D019047:Phantoms, Imaging; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D011880:Radiotherapy Planning, Computer-Assisted / Q000706:statistics & numerical data*
D011838:Radiation-Sensitizing Agents; D006371:Helium; D008094:Lithium; D001895:Boron