Role of alcohol in liver carcinogenesis.
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world and contributes significantly to cancer-related morbidity and mortality. Chronic alcohol consumption has long been associated with progressive liver disease toward the development of hepatic cirrhosis and the subsequent increased risk for developing HCC. In assessing the role of alcohol during hepatic disease, and as a carcinogen, many of the deleterious effects of alcohol can be attributed to alcohol metabolism in hepatocytes. In addition to the direct effects of alcohol/alcohol metabolism on hepatocyte transformation, increasing evidence indicates that other intrahepatic and systemic effects of alcohol are likely to play an equally significant role in the process of hepatic tumorigenesis.
McKillop
Iain H
IH
Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina 28203, USA. iain.mckillop@carolinashealthcare.org
Schrum
Laura W
LW
D000079:Acetaldehyde / Q000378:metabolism; D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced; D004249:DNA Damage; D018450:Disease Progression; D000431:Ethanol / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000209:etiology* / Q000378:metabolism; D008113:Liver Neoplasms / Q000209:etiology* / Q000378:metabolism; D018384:Oxidative Stress; D012307:Risk Factors
D000431:Ethanol; D000079:Acetaldehyde