title: Cardiogenic shock caused by disulfiram.
abstract: Drug intoxication with disulfiram is a rare condition that may lead to severe and potentially fatal cardiovascular manifestations such as cardiogenic shock. We report the case of a female patient with refractory shock after deliberate self-poisoning with disulfiram. Clinical, biochemical and echocardiographic assessment, as well as invasive monitoring confirmed cardiogenic shock associated with this drug. The known mechanisms of action of disulfiram are discussed, and the major collateral effects, especially cardiovascular effects, are described. We underscore the importance of suspecting this diagnosis and of adopting prompt and the most adequate therapeutic approach in this context.
authors.affiliation: Serviço de Cuidados Intensivos, Hospital Pedro Hispano, Matosinhos, Portugal. anajeronimo@hotmail.com
authors.forename: Ana
authors.initials: A
authors.lastname: Jerónimo
authors.forename: Carla
authors.initials: C
authors.lastname: Meira
authors.forename: Augusta
authors.initials: A
authors.lastname: Amaro
authors.forename: Glória Cabral
authors.initials: GC
authors.lastname: Campello
authors.forename: Cristina
authors.initials: C
authors.lastname: Granja
mesh_terms: D000427:Alcohol Deterrents / Q000506:poisoning*; D004221:Disulfiram / Q000506:poisoning*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000175:diagnosis; D013406:Suicide, Attempted
chemical_list: D000427:Alcohol Deterrents; D004221:Disulfiram