title: Evaluation of Gram-positive rod surveillance for early anthrax detection.
abstract: Since 2003, Connecticut laboratories have reported Gram-positive rod (GPR) isolates detected within 32 h of inoculation from blood or cerebrospinal fluid. The objectives were to rapidly identify inhalational anthrax and unusual Clostridium spp. infections, and to establish round-the-clock laboratory reporting of potential indicators of bioterrorism. From 2003 to 2006, Connecticut's GPR surveillance system identified 1134 isolates, including 657 Bacillus spp. (none B. anthracis) and 241 Clostridium spp. Reporting completeness and timeliness improved to 93% and 92%, respectively. Baseline rates of Bacillus spp., Clostridium spp. and other GPR findings have been established and are stable. Thus far, no cases of anthrax and no unusual clusters of Clostridium spp. have been detected by the GPR surveillance system. This system would probably have confirmed the inhalational anthrax case in Pennsylvania in 2006 3 days sooner than traditional reporting. Using audits and ongoing evaluation, the system has evolved into a highly functional 24/7 laboratory telephone reporting system with almost complete reporting.
authors.affiliation: Infectious Diseases Division, Connecticut Department of Public Health, Hartford, CT, USA. Diana.Mlynarski@ct.gov
authors.forename: D
authors.initials: D
authors.lastname: Mlynarski
authors.forename: T
authors.initials: T
authors.lastname: Rabatsky-Ehr
authors.forename: S
authors.initials: S
authors.lastname: Petit
authors.forename: K
authors.initials: K
authors.lastname: Purviance
authors.forename: P A
authors.initials: PA
authors.lastname: Mshar
authors.forename: E M
authors.initials: EM
authors.lastname: Begier
authors.forename: D G
authors.initials: DG
authors.lastname: Johnson
authors.forename: J L
authors.initials: JL
authors.lastname: Hadler
mesh_terms: D000881:Anthrax / Q000175:diagnosis*; D001408:Bacillus anthracis / Q000302:isolation & purification; D003013:Clostridium / Q000302:isolation & purification; D003237:Connecticut; D018563:Disease Notification; D016987:Gram-Positive Rods / Q000302:isolation & purification*; D006801:Humans; D011159:Population Surveillance / Q000379:methods*