title: Cytogenetic findings in a rare pediatric mixed glioneuronal tumor and review of the literature.
abstract: OBJECTIVE
  The aim of the present study was to report the chromosomal abnormalities findings in rare pediatric mixed glioneuronal tumor (GNT), which could not be classified according to the WHO classification.
  
  
  METHODS
  Cytogenetic studies were performed using G-banding and fluorescence in situ hybridization (FISH) techniques.
  
  
  RESULTS
  Cytogenetic analyses showed a deletion of 1p as primary genetic event and gain of chromosome 7 as secondary change. Furthermore, we present a review of available cytogenetic data of 72 pediatric patients with GNT. Taken into account these data and the present case, we found that the most frequent chromosomal anomalies involved gains of chromosomes 7 (15.1%), 5 (8.2%), 1q32-qter (6.8%), 8p21-qter (6.8%), 12 (5.5%), 18 (5.5%), 20q11-qter (5.5%), and X (5.5%). Frequent losses were detected on chromosome regions 1p (8.2%) and 22q (5.5%).
  
  
  CONCLUSIONS
  The findings of our case combined with those of previous reports suggest that chromosomes 1 and 7 may contain candidate genes involved in the tumorigenesis of GNT.
authors.affiliation: Cytogenetics Laboratory, Genetics Department, Garrahan Pediatrics Hospital, Buenos Aires, Argentina. marielacocce@yahoo.com.ar
authors.forename: Mariela C
authors.initials: MC
authors.lastname: Coccé
authors.forename: Fabiana
authors.initials: F
authors.lastname: Lubieniecki
authors.forename: Marcelo
authors.initials: M
authors.lastname: Bartuluchi
authors.forename: Marta S
authors.initials: MS
authors.lastname: Gallego
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D020732:Cytogenetic Analysis; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D009380:Neoplasms, Nerve Tissue / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D017384:Sequence Deletion; D016896:Treatment Outcome