title: Determination of prooxidant--antioxidant balance after acute coronary syndrome using a rapid assay: a pilot study.
abstract: The purpose of the current study was to investigate a novel measure of oxidative stress in patients with acute coronary syndrome (ACS) using a pro-oxidant-antioxidant balance (PAB) assay, which is simple and rapid. Blood samples were taken from 94 patients admitted with ACS. Pro-oxidant-antioxidant balance values were determined in the first and second 12 hours after the onset of symptoms and compared with values for 81 age- and sex-matched controls. The mean PAB values in the first and second 12-hour samples of patients were both significantly higher than that of controls (P < .001). Among patients, PAB values were also significantly higher in the second samples compared with the first samples (P < .001). These findings indicate a heightened state of oxidative stress following ACS and suggest that the PAB value may be considered as a cardiovascular risk predictor to estimate the extent of oxidative stress.
authors.affiliation: Cardiovascular Research Center, Avicenna Research Institute, Mashhad University of Medical Science (MUMS), Mashhad, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Daryoush Hamidi
authors.initials: DH
authors.lastname: Alamdari
authors.forename: Mohsen
authors.initials: M
authors.lastname: Moohebati
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.forename: Mohsen
authors.initials: M
authors.lastname: Nematy
authors.forename: Mohammad
authors.initials: M
authors.lastname: Safarian
authors.forename: Mohsen
authors.initials: M
authors.lastname: Azimi-Nezhad
authors.forename: Seyyed Mohammad Reza
authors.initials: SM
authors.lastname: Parizadeh
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: George
authors.initials: G
authors.lastname: Koliakos
authors.forename: Gordon
authors.initials: G
authors.lastname: Ferns
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010865:Pilot Projects; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000097:blood*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species