title: Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging.
abstract: Nanophotothermolysis with long laser pulses for treatment of scattered cancer cells and their clusters is introduced with the main focus on real-time monitoring of temperature dynamics inside and around individual cancer cells labeled with carbon nanotubes. This technique utilizes advanced time- and spatially-resolved thermal radiometry imaging for the visualization of laser-induced temperature distribution in multiple-point absorbing targets. The capability of this approach was demonstrated for monitoring of thermal effects under long laser exposure (from millisecond to seconds, wavelength 1,064 nm, maximum power 1 W) of cervical cancer HeLa cells labeled with carbon nanotubes in vitro. The applications are discussed with a focus on the nanophotothermolysis of small tumors, tumor margins, or micrometastases under the guidance of near-IR and microwave radiometry.
authors.affiliation: University of Arkansas at Little Rock, Applied Science Department, Nanotechnology Center, Little Rock, Arkansas 72204, USA. asbiris@ualr.edu
authors.forename: Alexandru S
authors.initials: AS
authors.lastname: Biris
authors.forename: Dorin
authors.initials: D
authors.lastname: Boldor
authors.forename: Jason
authors.initials: J
authors.lastname: Palmer
authors.forename: William T
authors.initials: WT
authors.lastname: Monroe
authors.forename: Meena
authors.initials: M
authors.lastname: Mahmood
authors.forename: Enkeleda
authors.initials: E
authors.lastname: Dervishi
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.forename: Zhongrui
authors.initials: Z
authors.lastname: Li
authors.forename: Ekaterina I
authors.initials: EI
authors.lastname: Galanzha
authors.forename: Vladimir P
authors.initials: VP
authors.lastname: Zharov
mesh_terms: D017209:Apoptosis / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays / Q000627:therapeutic use; D037742:Nanotubes, Carbon; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*; D013055:Spectrophotometry, Infrared / Q000379:methods*; D013817:Thermography / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D037742:Nanotubes, Carbon