title: [Stability: a factor to consider in antibiotic-lock solutions].
abstract: Antibiotic-lock therapy (ALT) has been related to a reduction in the need for catheter withdrawal in patients with catheter-related infection. The stability of the antimicrobial solutions used in ALT has not been sufficiently investigated. A systematic literature review was performed to identify articles including studies on the stability of ALT solutions. Nine studies fulfilled the inclusion criteria requiring specific drug determination techniques, and no apparent drug alterations were observed. The main microorganisms studied were Staphylococcus spp., Pseudomonas aeruginosa, and Klebsiella pneumoniae. The antibiotics included cefazolin, ceftazidime, ciprofloxacin, colistin, gentamicin, ticarcillin/clavulanate, and vancomycin in solution, administered alone or in combinations, with or without heparin. All solutions were fairly stable except for ciprofloxacin at a concentration of 10mg/mL. Few studies applied strict criteria to assess the stability of antibiotic solutions used in ALT; hence, the currently available data are limited. Therefore, it seems advisable to include appropriate stability studies in further research on the use of ALT.
authors.affiliation: Servicio de Farmacia, Hospital de Poniente, El Ejido, Almería, Spain. jmorales@imas.imim.es
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Morales-Molina
authors.forename: Javier
authors.initials: J
authors.lastname: Mateu-de Antonio
authors.forename: Santiago
authors.initials: S
authors.lastname: Grau
authors.forename: Marcel
authors.initials: M
authors.lastname: Segura
authors.forename: Pedro
authors.initials: P
authors.lastname: Acosta
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D016470:Bacteremia / Q000517:prevention & control*; D055499:Catheter-Related Infections / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects; D003428:Cross Infection / Q000517:prevention & control; D004355:Drug Stability; D006493:Heparin; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012996:Solutions; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D012996:Solutions; D006493:Heparin