Development of nanohydroxyapatite/polycarbonate composite for bone repair.
In this study, nano-hydroxyapatite (n-HA) combined polycarbonate was synthesized by a novel method. The physical and chemical property of the composite was tested. The results indicated the n-HA a crystal has the similar grain size, phase composition and crystal structure as. TEM photos results show the n-HA crystals were uniformly distributed in the polymer matrix. Then, the chemical bond between inorganic n-HA and polycarbonate was investigated and discussed. Proliferation of MSCs/composite cultured for up to 11 days the adhesion were tested by MTT and SEM. The in vitro test confirmed that the n-HA/PC composite was biocompatible and no negative effect on MSCs has found. The composite is proved to be osteoconductive, and can stimulate the growth of new bone. These results indicated that the composite meet the basic requirement of bone substitute material, and be potentially applied for clinic.
Liao Jianguo
School of Material Science & Engineering Henan Polytechnic University, Jiaozuo 454000, China.
Zhang Li
Zuo Yi
Wang Huanan
Li Jidong
Zou Qin
Li Yubao
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D017886:Durapatite / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D055119:Elastic Modulus; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D010316:Particle Size; D011076:Polycarboxylate Cement / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013055:Spectrophotometry, Infrared; D013718:Tensile Strength; D023822:Tissue Engineering / Q000379:methods*; D014961:X-Ray Diffraction
D018786:Bone Substitutes; D011076:Polycarboxylate Cement; C005506:polycarbonate; D017886:Durapatite