title: Usefulness of brachial-ankle pulse wave velocity as a predictive marker of multiple coronary artery occlusive disease in Korean type 2 diabetes patients.
abstract: Multiple coronary artery occlusive disease (multiple CAOD) is the most fatal and frequently observed coronary artery disease in type 2 diabetes patients, but no simple, non-invasive screening tool is available yet. The aim of this study is to evaluate the arterial stiffness in type 2 diabetes patients using brachial-ankle pulse wave velocity (baPWV), to demonstrate the correlation between arterial stiffness and multiple CAOD, and to suggest the cutoff point of baPWV for predicting multiple CAOD in Korean type 2 diabetes patients. One hundred and eighty-one diabetes and 262 non-diabetes patients were enrolled in the study. Routine anthropometric and serologic data were collected. baPWV was measured the day before coronary angiography, and the severity of CAOD was assessed with Gensini score after angiography. baPWV and Gensini score were significantly increased in diabetes patients and Gensini score had a positive correlation with baPWV. Subjects in the highest tertile of baPWV showed odds ratio of 3.06 for multiple CAOD compared to the lowest tertile. In ROC curve, baPWV at 1635 cm/s showed 73% sensitivity and 75% specificity with AUC 0.76 in diabetes patients in detecting multiple CAOD. Therefore, baPWV may be utilized a screening tool for predicting multiple CAOD, especially in type 2 diabetes patients.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hai Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Ji Sun
authors.initials: JS
authors.lastname: Nam
authors.forename: Jong Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Minho
authors.initials: M
authors.lastname: Cho
authors.forename: Chul Sik
authors.initials: CS
authors.lastname: Kim
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Ahn
authors.forename: Hyuck Moon
authors.initials: HM
authors.lastname: Kwon
authors.forename: Bum Kee
authors.initials: BK
authors.lastname: Hong
authors.forename: Young Won
authors.initials: YW
authors.lastname: Yoon
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Cha
authors.forename: Kyung Rae
authors.initials: KR
authors.lastname: Kim
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Lee
mesh_terms: D000368:Aged; D000842:Ankle / Q000098:blood supply*; D055109:Ankle Brachial Index / Q000379:methods*; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D003327:Coronary Disease / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011674:Pulse; D012680:Sensitivity and Specificity
chemical_list: D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein