[Effect of isomerization of aspartate-7 on the binding of copper (II) ion by the beta-amyloid peptide].
It has been shown for the first time by the method of isothermal calorimetry of titration that the N-terminal amino group of the beta-amyloid protein, which plays a key role in the binding of copper ion, ceases to form the proper coordinating bond as a result of the isomerization of aspartate-7.
Tsvetkov
F O
FO
Makarov
A A
AA
Archakov
A I
AI
Kozin
S A
SA
D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D001224:Aspartic Acid / Q000737:chemistry* / Q000378:metabolism; D002413:Cations, Divalent / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007536:Isomerism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding
D016229:Amyloid beta-Peptides; D002413:Cations, Divalent; D010455:Peptides; D001224:Aspartic Acid; D003300:Copper