title: Design of an accelerator-based neutron source for neutron capture therapy.
abstract: The boron neutron capture therapy is mainly suited in the treatment of some tumor kinds which revealed ineffective to the traditional radiotherapy. In order to take advantage of such a therapeutic modality in hospital environments, neutron beams of suitable energy and flux levels provided by compact size facilities are needed. The advantages and drawbacks of several neutron beams are here analysed in terms of therapeutic gains. In detail the GEANT-3/MICAP simulations show that high tumor control probability, with sub-lethal dose at healthy tissues, can be achieved by using neutron beams of few keV energy having a flux of about 10(9) neutrons/(cm(2)s). To produce such a neutron beam, the feasibility of a proton accelerator is investigated. In particular an appropriate choice of the radiofrequency parameters (modulation, efficiency of acceleration, phase shift, etc.) allows the development of relatively compact accelerators, having a proton beam current of 30 mA and an energy of 2 MeV, which could eventually lead to setting up of hospital-based neutron facilities.
authors.affiliation: Istituto Nazionale di Fisica Nucleare and Dipartimento di Fisica Università di Bari, Via Orabona, 4, Bari, Italy. ritaterlizzi@libero.it
authors.forename: R
authors.initials: R
authors.lastname: Terlizzi
authors.forename: N
authors.initials: N
authors.lastname: Colonna
authors.forename: P
authors.initials: P
authors.lastname: Colangelo
authors.forename: A
authors.initials: A
authors.lastname: Maiorana
authors.forename: S
authors.initials: S
authors.lastname: Marrone
authors.forename: A
authors.initials: A
authors.lastname: Rainò
authors.forename: G
authors.initials: G
authors.lastname: Tagliente
authors.forename: V
authors.initials: V
authors.lastname: Variale
mesh_terms: D055592:Biophysical Phenomena; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation*; D001932:Brain Neoplasms / Q000532:radiotherapy; D004867:Equipment Design; D005214:Fast Neutrons / Q000627:therapeutic use; D006801:Humans; D009010:Monte Carlo Method; D009502:Neutrons / Q000627:therapeutic use*; D010315:Particle Accelerators; D019047:Phantoms, Imaging / Q000706:statistics & numerical data; D011522:Protons
chemical_list: D011522:Protons