Mixed micelle systems formed from critical micelle concentration and temperature-sensitive diblock copolymers for doxorubicin delivery.
Mixed micelles formed by critical micelle concentration (Cmc) character's diblock copolymer, and temperature-sensitive character's diblock copolymer were studied for their capabilities in improving stability with and without drug. Experimental results showed that this type of mixed micellar systems possessed complementary effects in adjusting external temperature shift (storage vs. body temperature) and concentration change (dilution after intravenous injection). Therefore, they provided excellent stability as drug carriers. Further results obtained from physicochemical property and drug release kinetics studies demonstrated such systems could also be applied to physiological conditions, in compliance with varied pH environments. We concluded that the newly developed mixed micelles can serve as a potential injectable drug delivery system for anticancer drugs, such as doxorubicin and many others.
Lo
Chun-Liang
CL
Department of Chemical Engineering, National Tsing Hua University, 101, Section 2, Kuang Fu Road, Hsinchu 300, Taiwan, ROC.
Lin
Sheng-Jie
SJ
Tsai
Hsieh-Chih
HC
Chan
Wei-Hsiang
WH
Tsai
Cheng-Hung
CH
Cheng
Chien-Hsin D
CH
Hsiue
Ging-Ho
GH
D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008823:Micelles; D015394:Molecular Structure; D013696:Temperature
D004337:Drug Carriers; D008823:Micelles; D004317:Doxorubicin