title: Comparative efficacy of nonpurpuragenic pulsed dye laser and intense pulsed light for erythematotelangiectatic rosacea.
abstract: BACKGROUND
  Erythematotelangiectatic (ET) rosacea is commonly treated with a variety of laser and light-based systems. Although many have been used successfully, there are a limited number of comparative efficacy studies.
  
  
  OBJECTIVE
  To compare nonpurpuragenic pulsed dye laser (PDL) with intense pulsed light (IPL) treatment in the ability to reduce erythema, telangiectasia, and symptoms in patients with moderate facial ET rosacea.
  
  
  METHODS
  Twenty-nine patients were enrolled in a randomized, controlled, single-blind, split-face trial with nonpurpuragenic treatment with PDL and IPL and untreated control. Three monthly treatment sessions were performed with initial PDL settings of 10-mm spot size, 7 J/cm(2), 6-ms pulse duration and cryogen cooling, and initial IPL settings of 560-nm filter, a pulse train of 2.4 and 6.0 ms in duration separated by a 15-ms delay, and a starting fluence of 25 J/cm(2). Evaluation measures included spectrophotometric erythema scores, blinded investigator grading, and patient assessment of severity and associated symptoms.
  
  
  RESULTS
  PDL and IPL resulted in significant reduction in cutaneous erythema, telangiectasia, and patient-reported associated symptoms. No significant difference was noted between PDL and IPL treatment.
  
  
  CONCLUSIONS
  A series of nonpurpuragenic PDL and IPL treatments in ET rosacea was performed with similar efficacy and safety, and both modalities seem to be reasonable choices for the treatment of ET rosacea.
authors.affiliation: Dermatologic Surgery and Laser Center, Department of Dermatology, University of California, San Francisco, 1701 Divisadero Street, 3rd Floor, San Francisco, CA 94115, USA. neuhausi@derm.ucsf.edu
authors.forename: Isaac M
authors.initials: IM
authors.lastname: Neuhaus
authors.forename: Lee T
authors.initials: LT
authors.lastname: Zane
authors.forename: Whitney D
authors.initials: WD
authors.lastname: Tope
mesh_terms: D004890:Erythema / Q000473:pathology / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D054025:Lasers, Dye / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D012393:Rosacea / Q000473:pathology / Q000532:radiotherapy*; D016037:Single-Blind Method; D013053:Spectrophotometry; D016896:Treatment Outcome