title: Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials.
abstract: Modern microfabrication techniques make it possible to develop microelectrode arrays that may be utilized not only in neurophysiological research but also in the clinic, e.g. in neurosurgery and as elements of neural prostheses. The aim of this study was to test whether a flexible microelectrode array is suitable for recording cortical surface field potentials in rats. Polyimide-based microelectrode arrays were fabricated by utilizing microfabrication techniques e.g. photolithography and magnetron sputter deposition. The present microelectrode array consists of eight platinum microelectrodes (round-shaped, Ø: 200 microm), transmission lines and connector pads sandwiched between two thin layers of biocompatible polyimide. The microelectrode arrays were electrochemically characterized by impedance spectroscopy in physiological saline solution and successfully tested in vivo by conducting acute and chronic measurements of evoked potentials on the surface of rat cortex. The arrays proved excellent flexibility and mechanical strength during handling and implantation onto the surface of cortex. The excellent electrochemical characteristics and stable in vivo recordings with high spatiotemporal resolution highlight the potential of these arrays. The fabrication protocol described here allows implementation of several other neural interfaces with different layouts, material selections or target areas either for recording or stimulation purposes.
authors.affiliation: Department of Physics, University of Kuopio, Kuopio, Finland. sami.myllymaa@uku.fi
authors.forename: Sami
authors.initials: S
authors.lastname: Myllymaa
authors.forename: Katja
authors.initials: K
authors.lastname: Myllymaa
authors.forename: Hannu
authors.initials: H
authors.lastname: Korhonen
authors.forename: Juha
authors.initials: J
authors.lastname: Töyräs
authors.forename: Juha E
authors.initials: JE
authors.lastname: Jääskeläinen
authors.forename: Kaj
authors.initials: K
authors.lastname: Djupsund
authors.forename: Heikki
authors.initials: H
authors.lastname: Tanila
authors.forename: Reijo
authors.initials: R
authors.lastname: Lappalainen
mesh_terms: D000818:Animals; D001931:Brain Mapping / Q000295:instrumentation* / Q000379:methods; D002540:Cerebral Cortex / Q000502:physiology*; D017097:Electric Impedance; D055664:Electrochemical Techniques; D004569:Electroencephalography / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D005073:Evoked Potentials, Somatosensory; D008839:Microelectrodes; D011108:Polymers; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011108:Polymers