Evaluation of efficacy and safety of anterior corpus callosotomy with keyhole in refractory seizures.
OBJECTIVE
This study was conducted to evaluate the efficacy and safety of anterior corpus callosotomy with a keyhole approach on refractory seizures and to evaluate this procedure for drop attacks (DAs) and generalized tonic-clonic seizures (GTCSs).


METHODS
All refractory seizure patients underwent anterior corpus callosotomy (n=31) without other epilepsy surgery. Seizure response and procedure complications were evaluated.


RESULTS
Seizure types included GTCS (n=26), and atonic or tonic seizures with DA (n=9). In GTCS patients, 84.6% had >or=50% decrease in seizure frequency, and 61.5% had >or=80% reduction. In DA patients, 77.8% had >or=50% decrease in seizure frequency, and 55.6% had >or=80% reduction. There were no statistically significant differences between the groups in final efficacy. Overall complication rate for corpus callosotomy was 12.9%, the permanent complication rate was 3.2%.


CONCLUSIONS
Anterior corpus callosotomy with a keyhole approach produces highly favorable outcomes for both GTCS and atonic or tonic seizures with a low risk for complications.
Ping
Zheng
Z
Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Ji-Wen
Xu
X
Gui-Song
Wang
W
Hong-Yu
Zhou
Z
Xin
Tian
T
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000601:surgery*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000473:pathology* / Q000601:surgery*; D050812:Split-Brain Procedure / Q000009:adverse effects* / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult