Relation of exhaled nitric oxide levels to development of bronchopulmonary dysplasia.
OBJECTIVE
To test the hypothesis that exhaled nitric oxide levels on day 28 and changes in exhaled nitric oxide levels in the neonatal period would differ according to whether infants developed bronchopulmonary dysplasia (BPD) and its severity.


METHODS
Prospective observational study.


METHODS
Tertiary neonatal intensive care unit.


METHODS
80 infants (median gestational age 28, range 24-32 weeks), 46 of whom developed BPD.


METHODS
Exhaled nitric oxide measurements were attempted on days 3, 5, 7, 14, 21 and 28.


METHODS
BPD (oxygen dependency at 28 days), mild BPD (oxygen dependent at 28 days, but not 36 weeks postmenstrual age (PMA)); moderate BPD (oxygen dependent at 36 weeks PMA) and severe BPD (respiratory support dependent at 36 weeks PMA).


RESULTS
On day 28, exhaled nitric oxide levels were higher in infants with BPD compared to those without BPD (p<0.001) and there was a linear trend in exhaled nitric oxide results as BPD severity increased (p = 0.006). No significances in the change in exhaled nitric oxide levels over the neonatal period were found between the four groups.


CONCLUSIONS
Exhaled nitric oxide levels are raised in infants with established BPD, particularly in those developing moderate or severe BPD, and may reflect ongoing inflammation.
May
C
C
Division of Asthma, Allergy and Lung Biology, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
Williams
O
O
Milner
A D
AD
Peacock
J
J
Rafferty
G F
GF
Hannam
S
S
Greenough
A
A
D001944:Breath Tests; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D045853:Exhalation; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009569:Nitric Oxide / Q000032:analysis*; D011446:Prospective Studies
D009569:Nitric Oxide