title: FASLG polymorphism is associated with cancer risk.
abstract: Many studies have reported the association between the FASLG -844T/C polymorphism and cancer risk, but the data are remaining controversial. A pooled analysis was performed to assess this relationship comprehensively. Medline, PubMed, Embase and Web of Science were searched, and data were extracted and cross-checked independently by three authors. A total of 18 published studies including 22389 subjects were involved in this analysis. Overall, the -844C allele was associated with a significantly increased cancer risk (for CC versus TT: OR=1.23, 95% confidence interval (CI)=1.04-1.45; for CC+TC versus TT: OR=1.15, 95% CI=1.01-1.30; for CC versus TT+TC: OR=1.20, 95% CI=1.05-1.38). In the subgroup analysis by ethnicity, significantly elevated risks were found among Asians (for CC versus TT: OR=1.61, 95% CI=1.37-1.89; for CC+TC versus TT: OR=1.36, 95% CI=1.16-1.60; for CC versus TT+TC: OR=1.44, 95% CI=1.22-1.70). In the subgroup analysis by study design, significantly increased risks were found among population-based case-control studies (for CC versus TT: OR=1.40, 95% CI=1.06-1.84; for CC+TC versus TT: OR=1.25, 95% CI=1.01-1.55; for CC versus TT+TC: OR=1.31, 95% CI=1.06-1.61). These findings indicate that the FASLG -844C allele is emerging as a low-penetrant cancer susceptibility allele for cancer development. However, more comprehensive understanding of the association would certainly have an immense prospect in the promising field of individualised preventive care.
authors.affiliation: Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Qian-Jun
authors.initials: QJ
authors.lastname: Wen
authors.forename: You
authors.initials: Y
authors.lastname: Yin
authors.forename: Xiao-Tong
authors.initials: XT
authors.lastname: Lu
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Pu
authors.forename: Huai-Ping
authors.initials: HP
authors.lastname: Tian
authors.forename: Yue-Fen
authors.initials: YF
authors.lastname: Lou
authors.forename: Yue-Nian
authors.initials: YN
authors.lastname: Tang
authors.forename: Xin
authors.initials: X
authors.lastname: Jiang
authors.forename: Gen-Sheng
authors.initials: GS
authors.lastname: Lu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016001:Confidence Intervals; D053222:Fas Ligand Protein / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: D053222:Fas Ligand Protein