The roles of phospholipase D in EGFR signaling.
Epidermal growth factor receptor (EGFR) is a representative model of receptor tyrosine kinases (RTKs), and offers a means of understanding their common principles and fundamental mechanisms. Furthermore, EGFR plays an essential role in cell proliferation and migration, and the disruption of EGFR signaling has been implicated in the development and growth of cancer. Phospholipase D (PLD) is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner. PLD regulates downstream molecules by generating phosphatidic acid (PA), but it also dynamically interacts with a variety of intracellular molecules and these interactions spatiotemporally regulate EGFR function and serve as a hub that orchestrates signaling flow. This review summarizes the interrelationship between PLD and its binding molecules in the context of EGFR signaling, and addresses the roles of PLD in the mediation and coordination of this signaling.
Lee
Chang Sup
CS
Department of Life Science and Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, South Korea.
Kim
Kyung Lock
KL
Jang
Jin Hyeok
JH
Choi
Yoon Sup
YS
Suh
Pann-Ghill
PG
Ryu
Sung Ho
SH
D000818:Animals; D004705:Endocytosis / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000494:pharmacology; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D010739:Phospholipase D / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects
D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D010739:Phospholipase D