title: Anti-inflammatory drugs reduce age-related decreases in brain volume in cognitively normal older adults.
abstract: Previous studies have indicated a decreased risk for developing Alzheimer's disease in anti-inflammatory (AI) drug users. Yet few studies have determined whether AI drug use provides a protective effect against normal age-related changes in the brains of older adults. Regional volume changes in gray and white matter were assessed cross-sectionally using optimized voxel-based morphometry in 36 females taking AI drugs as arthritis or pain medication and 36 age- and education-matched female controls. Although mean gray and white matter volume differences between AI drug users and the non-AI group were small, AI drug use interacted with age, such that the non-AI group showed significantly greater age-related volume changes in regions of both gray and white matter compared to the AI drug users. These regions included the superior and medial frontal gyri, middle and inferior temporal gyri, fusiform and parahippocampal gyri, and occipital gray matter as well as temporal, parietal, and midbrain white matter. The results are consistent with the notion that AI drugs provide protection against age-related changes in brain volume. It is possible that inflammation plays a role in volume decreases associated with normal aging, and that suppressing the inflammatory response moderates this decrease.
authors.affiliation: Cognition and Neuroimaging Laboratories, Department of Psychology, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: K
authors.initials: K
authors.lastname: Walther
authors.forename: B B
authors.initials: BB
authors.lastname: Bendlin
authors.forename: E L
authors.initials: EL
authors.lastname: Glisky
authors.forename: T P
authors.initials: TP
authors.lastname: Trouard
authors.forename: J R
authors.initials: JR
authors.lastname: Lisse
authors.forename: J O
authors.initials: JO
authors.lastname: Posever
authors.forename: L
authors.initials: L
authors.lastname: Ryan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects* / Q000473:pathology; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000145:classification; D001130:Arizona; D001168:Arthritis / Q000188:drug therapy / Q000473:pathology*; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged
chemical_list: D000893:Anti-Inflammatory Agents