title: Sleep and psychoneuroimmunology.
abstract: The brain uses a variety of mechanisms to survey the immune system constantly. Responses of the immune system to invading pathogens are detected by the central nervous system, which responds by orchestrating complex changes in behavior and physiology. Sleep is one of the behaviors altered in response to immune challenge. The role of cytokines as mediators of responses to infectious challenge and regulators and modulators of sleep is the focus of this article.
authors.affiliation: Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109-0615, USA. mopp@umich.edu
authors.forename: Mark R
authors.initials: MR
authors.lastname: Opp
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D004594:Electrophysiology; D006801:Humans; D011598:Psychoneuroimmunology; D012890:Sleep; D014777:Virus Diseases / Q000276:immunology
chemical_list: D016207:Cytokines