Lymphocytic infundibulo-neurohypophysitis: An unusual cause of recurrent optic neuropathy in a child.
Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk.(1) We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH.(2) This is the first report of optic neuropathy in association with LINH in a child.
Al-Mujaini
Abdullah
A
Department of Ophthalmology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.
Ganesh
Anuradha
A
Al-Zuhaibi
Sana
S
Al-Dhuhli
Humoud
H
Al-Mashani
Ali
A
Al-Kindi
Hunaina
H
Al-Memari
Ali
A
Al-Futaisi
Amna
A
Al-Asmi
Abdullah
A
D001327:Autoimmune Diseases / Q000150:complications* / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D002648:Child; D003919:Diabetes Insipidus / Q000209:etiology / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009901:Optic Nerve Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D010900:Pituitary Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D010902:Pituitary Gland / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D012008:Recurrence