title: ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization.
abstract: Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at <igrid-ext.cryst.bbk.ac.uk/immunogrid>.
authors.affiliation: Cancer Vaccine Center, Dana-Farber Cancer Institute, 77 Avenue Louis Pasteur, HIM 401, Boston, MA 02115, USA.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pappalardo
authors.forename: Mark D
authors.initials: MD
authors.lastname: Halling-Brown
authors.forename: Nicolas
authors.initials: N
authors.lastname: Rapin
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Davide
authors.initials: D
authors.lastname: Alemani
authors.forename: Andrew
authors.initials: A
authors.lastname: Emerson
authors.forename: Paola
authors.initials: P
authors.lastname: Paci
authors.forename: Patrice
authors.initials: P
authors.lastname: Duroux
authors.forename: Marzio
authors.initials: M
authors.lastname: Pennisi
authors.forename: Arianna
authors.initials: A
authors.lastname: Palladini
authors.forename: Olivo
authors.initials: O
authors.lastname: Miotto
authors.forename: Daniel
authors.initials: D
authors.lastname: Churchill
authors.forename: Elda
authors.initials: E
authors.lastname: Rossi
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Shepherd
authors.forename: David S
authors.initials: DS
authors.lastname: Moss
authors.forename: Filippo
authors.initials: F
authors.lastname: Castiglione
authors.forename: Massimo
authors.initials: M
authors.lastname: Bernaschi
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Lefranc
authors.forename: Søren
authors.initials: S
authors.lastname: Brunak
authors.forename: Santo
authors.initials: S
authors.lastname: Motta
authors.forename: Pier-Luigi
authors.initials: PL
authors.lastname: Lollini
authors.forename: Kaye E
authors.initials: KE
authors.lastname: Basford
authors.forename: Vladimir
authors.initials: V
authors.lastname: Brusic
mesh_terms: D019295:Computational Biology / Q000379:methods; D003199:Computer Systems; D003628:Database Management Systems; D016208:Databases, Factual; D015195:Drug Design; D006801:Humans; D007107:Immune System / Q000502:physiology*; D008285:Major Histocompatibility Complex; D008954:Models, Biological; D018511:Systems Integration; D014612:Vaccines
chemical_list: D014612:Vaccines