title: Indium-catalyzed reductive alkylation of pyrroles with alkynes and hydrosilanes: selective synthesis of beta-alkylpyrroles.
abstract: Mixing readily available alkynes, pyrroles, and triethylsilane along with an indium catalyst was found to be an efficient procedure to introduce alkyl groups onto a beta-position of pyrroles in a complete regioselective manner. This is the first demonstration of catalytic beta-alkylation of pyrroles in a single step.
authors.affiliation: Department of Applied Chemistry, School of Science and Technology, Meiji University, Higashimita, Tama-ku, Kawasaki 214-8571, Japan. tsuchimo@isc.meiji.ac.jp
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Tsuchimoto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Wagatsuma
authors.forename: Kazuki
authors.initials: K
authors.lastname: Aoki
authors.forename: Jun
authors.initials: J
authors.lastname: Shimotori
mesh_terms: D000478:Alkylation; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007204:Indium / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D011758:Pyrroles; D012821:Silanes; D007204:Indium