title: Correlation of FBX dosimeter and micronucleus assay in radiation dosimetry of gamma chambers.
abstract: The aim of the present study is to determine the dose distribution in gamma irradiation chambers by chemical dosimetry and to establish its correlation with biological dosimetry. The dose-distribution studies of these two gamma chambers show that compared to the center point of the chambers, the dose rate was 17%-22% higher at the circumference. Moreover, the dose rate was 12%-18% lower at the bottom and top positions compared to the center point. It was interesting to observe that the dose rate determined by chemical dosimetry was well correlated with the number of micro-nucleus (MN) formations at different positions of the chamber. Our results suggest that the formation of the single MN/cell was better correlated with the dose rate than the double MN/cell, suggesting that the number of single MN/cells could be better biomarkers for determining the dose rate. These results provide a correlation between chemical and biological dosimetry, which may have relevance in the development of better bioassay techniques for radiation exposure.
authors.affiliation: Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai - 400085, India.
authors.forename: Manjoor
authors.initials: M
authors.lastname: Ali
authors.forename: Prabha
authors.initials: P
authors.lastname: Tiwari
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Kaushala Prasad
authors.initials: KP
authors.lastname: Mishra
authors.forename: Badri Narain
authors.initials: BN
authors.lastname: Pandey
mesh_terms: D000328:Adult; D001773:Blood Cells / Q000528:radiation effects; D002478:Cells, Cultured; D005720:Gamma Rays; D006801:Humans; D008297:Male; D015162:Micronucleus Tests; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods*; D013051:Spectrometry, Gamma