title: Diastolic function study with conventional and pulsed tissue Doppler echocardiography imaging in acromegalic patients.
abstract: Acromegaly is associated with myocardial hypertrophy and it can progress to diastolic and systolic dysfunction.
  
  
  OBJECTIVE
  To evaluate diastolic function in acromegalic patients through conventional echocardiography (CD) and tissue Doppler imaging (TDI).
  
  
  METHODS
  Seventeen acromegalic patients were submitted to CD and TDI, and early (E) and atriogenic (A) transmitral flow were evaluated in mitral, septal, and tricuspid regions.
  
  
  RESULTS
  In comparison with controls the means of conventional (1.06), septal (1.01), and tricuspid (0.98) E/A ratio were significantly lower in acromegalic patients. E/A ratio <1.0 was demonstrated in 41% and 49% of acromegalics by DC and TDI, respectively, with no statistical difference among the two methods. An inverse linear correlation was shown between mitral E/A ratio and acromegalic age (r =-0.7).
  
  
  CONCLUSIONS
  In this study, DC and TDI were equally effective in demonstrating diastolic dysfunction, a common finding in acromegalic patients.
authors.affiliation: Discipline of Endocrinology, Medicine Faculty, Fundação Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
authors.forename: Carolina G S
authors.initials: CG
authors.lastname: Leães
authors.forename: Caroline K
authors.initials: CK
authors.lastname: Kramer
authors.forename: Julia F S
authors.initials: JF
authors.lastname: Pereira-Lima
authors.forename: Domingos M
authors.initials: DM
authors.lastname: Hatem
authors.forename: Iran
authors.initials: I
authors.lastname: Castro
authors.forename: Miriam da C
authors.initials: Mda C
authors.lastname: Oliveira
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000151:congenital* / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018617:Ultrasonography, Doppler, Pulsed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000151:congenital* / Q000000981:diagnostic imaging*