Photoacoustic tomography of the mouse cerebral cortex with a high-numerical-aperture-based virtual point detector.
The mouse cerebral cortex was imaged in situ by photoacoustic tomography (PAT). Instead of a flat ultrasonic transducer, a virtual point detector based on a high numerical aperture (NA), positively focused transducer was used. This virtual point detector has a wide omnidirectional acceptance angle, a high sensitivity, and a negligible aperture effect. In addition, the virtual point detector can be located much more closely to the object during the detection. Compared with a finite-size flat transducer, images generated by using this virtual point detector have both uniform signal-to-noise ratio (SNR) and resolution.
Li
Changhui
C
Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, St. Louis, Missouri 63130, USA.
Wang
Lihong V
LV
D000818:Animals; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D017076:Computer-Aided Design; D054459:Elasticity Imaging Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D051379:Mice; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014159:Transducers; D014584:User-Computer Interface