title: Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones as potential TACE inhibitors: design, synthesis, molecular modeling, and preliminary biological evaluation.
abstract: Compounds belonging to the class of 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones were synthesized and evaluated for their TACE inhibitory activity. Most of the compounds showed very good TACE inhibitory activity. Docking study clearly indicates importance of the P1' group of the inhibitor for the TACE inhibitory activity. This work proves that these two classes of molecules could be used as potential leads for the development of TACE inhibitors.
authors.affiliation: Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M. S. University of Baroda, Vadodara 390 001, Gujarat, India.
authors.forename: Shirshendu
authors.initials: S
authors.lastname: DasGupta
authors.forename: Prashant R
authors.initials: PR
authors.lastname: Murumkar
authors.forename: Rajani
authors.initials: R
authors.lastname: Giridhar
authors.forename: Mange Ram
authors.initials: MR
authors.lastname: Yadav
mesh_terms: D051722:ADAM Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000072198:ADAM17 Protein; D045744:Cell Line, Tumor; D003198:Computer Simulation; D015195:Drug Design; D006801:Humans; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008956:Models, Chemical; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D048289:Imidazolidines; D011480:Protease Inhibitors; D011744:Pyrimidinones; D051722:ADAM Proteins; D000072198:ADAM17 Protein; C000606462:ADAM17 protein, human