The CALM and CALM/AF10 interactor CATS is a marker for proliferation.
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.
Archangelo
Leticia Fröhlich
LF
Department of Medicine III, University of Munich Hospital Grosshadern, German Research Center for Environmental Health, Munich, Germany.
Greif
Philipp A
PA
Hölzel
Michael
M
Harasim
Thomas
T
Kremmer
Elisabeth
E
Przemeck
Gerhard K H
GK
Eick
Dirk
D
Deshpande
Aniruddha Jayant
AJ
Buske
Christian
C
de Angelis
Martin Hrabé
MH
Saad
Sara Teresinha Olalla
ST
Bohlander
Stefan K
SK
D000818:Animals; D014408:Biomarkers, Tumor; D002352:Carrier Proteins / Q000032:analysis / Q000235:genetics*; D002453:Cell Cycle; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D047108:Embryonic Development / Q000235:genetics*; D020043:Genes, Essential / Q000235:genetics; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007938:Leukemia / Q000209:etiology; D051379:Mice; D034041:Monomeric Clathrin Assembly Proteins / Q000032:analysis / Q000235:genetics*; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D012334:RNA, Neoplasm / Q000032:analysis
D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D034041:Monomeric Clathrin Assembly Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; C512398:PIMREG protein, human; D012334:RNA, Neoplasm