[Expression of ZNF217 in human ovarian cystadenocarcinoma and its clinical significance].
OBJECTIVE
To explore the correlation of ZNF217 expression to the carcinogenesis and progression of human ovarian cancer.


METHODS
Immunohistochemistry and real-time RT-PCR were used to detect ZNF217 expression in human ovarian cystadenocarcinoma, ovarian cystadenoma and normal ovary tissues.


RESULTS
The expression levels of ZNF217 protein and mRNA in ovarian cystadenocarcinoma was significantly higher than those in matched ovarian cystadenoma and normal tissues (P<0.05). No significant difference was found in the expression between ovarian cystadenoma and normal ovarian tissues (P>0.05). The mRNA expression in the specimens was consistent with the protein expression of ZNF217 (P<0.05).


CONCLUSIONS
ZNF217 gene expression is closely correlated to the occurrence and clinical stages of ovarian carcinomas, suggesting that ZNF217 can be an important candidate gene responsible for the occurrence and progression of ovarian carcinomas.
Sun
Gui-qin
GQ
Department of Obstetrics and Gynecology; Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. guiqinsun@gmail.com
Zhong
Mei
M
Ding
Yan-qing
YQ
Su
Gui-dong
GD
Song
Tian-rong
TR
Yin
Ai-lan
AL
D003536:Cystadenocarcinoma / Q000235:genetics* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D015534:Trans-Activators / Q000235:genetics*
D015534:Trans-Activators; C113698:ZNF217 protein, human