CD4+ T cells and immunosenescence--a mini-review.
Age-related declines in immune function are associated with reduced humoral responses following vaccination or infection. Central to this defect is a decline in naïve CD4+ T cell function. In this review, we discuss factors intrinsic and extrinsic to the CD4+ T cell compartment that affect host immunity and propose means by which deficient CD4+ T cell function can be fully restored in the aged.
Maue
Alexander C
AC
Trudeau Institute, Saranac Lake, NY 12983, USA.
Haynes
Laura
L
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000368:Aged; D000375:Aging / Q000276:immunology*; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D051379:Mice; D014612:Vaccines / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D014612:Vaccines