Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: a randomised, double-blind, controlled pilot study.
OBJECTIVE
To investigate the anti-fatigue effects of Myelophil, an extract of a mix of Astragali Radix and Salviae Radix, which has been used to treat patients with chronic fatigue.


METHODS
A randomised, double-blind, controlled clinical trial was performed with 36 adults who complained of chronic fatigue. The subjects were divided among a control group and low- and high-dose groups (3 or 6g of oral Myelophil per day, respectively) and were monitored for 4 weeks. Fatigue severity was subjectively characterised, and the expression of 42 cytokines was evaluated using an antibody array.


RESULTS
Myelophil administration (3g per day) significantly decreased the fatigue severity score compared with the control (p<0.05). No changes were noted in cytokine expression.


CONCLUSIONS
Myelophil appears to have a pharmacological effect against fatigue, suggesting the clinical relevance of the traditional medicinal plants, Astragalus membranaceus and Salvia miltiorrhiza.
Cho
J H
JH
East-West Cancer Center, Dunsan Oriental Hospital of Oriental Medical College of Daejeon University, Seo-gu, Daejeon, South Korea.
Cho
C K
CK
Shin
J W
JW
Son
J Y
JY
Kang
W
W
Son
C G
CG
D000328:Adult; D027885:Astragalus propinquus; D016207:Cytokines / Q000097:blood / Q000276:immunology; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D015673:Fatigue Syndrome, Chronic / Q000145:classification / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D010946:Plants, Medicinal; D027561:Salvia miltiorrhiza; D012720:Severity of Illness Index; D055815:Young Adult
D016207:Cytokines; D004365:Drugs, Chinese Herbal; C530779:Myelophil; D010936:Plant Extracts