title: Fluorenone alkaloid from Caulophyllum robustum Maxim. with anti-myocardial ischemia activity.
abstract: A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustum Maxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.
authors.affiliation: School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.
authors.forename: Sicen
authors.initials: S
authors.lastname: Wang
authors.forename: Binyu
authors.initials: B
authors.lastname: Wen
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.forename: Juntian
authors.initials: J
authors.lastname: Liu
authors.forename: Langchong
authors.initials: L
authors.lastname: He
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002317:Cardiovascular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028145:Caulophyllum / Q000737:chemistry; D002845:Chromatography / Q000379:methods; D004195:Disease Models, Animal; D005449:Fluorenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D009203:Myocardial Infarction / Q000473:pathology / Q000517:prevention & control*; D017202:Myocardial Ischemia / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000470:Alkaloids; D002317:Cardiovascular Agents; D005449:Fluorenes