title: Neural respiratory drive in obesity.
abstract: BACKGROUND
  The load imposed on ventilation by increased body mass contributes to the respiratory symptoms caused by obesity. A study was conducted to quantify ventilatory load and respiratory drive in obesity in both the upright and supine postures.
  
  
  METHODS
  Resting breathing when seated and supine was studied in 30 obese subjects (mean (SD) body mass index (BMI) 42.8 (8.6) kg/m(2)) and 30 normal subjects (mean (SD) BMI 23.6 (3.7) kg/m(2)), recording the electromyogram of the diaphragm (EMGdi, transoesophageal multipair electrode), gastric and oesophageal pressures.
  
  
  RESULTS
  Ventilatory load and neural drive were higher in the obese group as judged by the EMGdi (21.9 (9.0) vs 8.4 (4.0)%max, p<0.001) and oesophageal pressure swings (9.6 (2.9) vs 5.3 (2.2) cm H(2)O, p<0.001). The supine posture caused an increase in oesophageal pressure swings to 16.0 (5.0) cm H(2)O in obese subjects (p<0.001) and to 6.9 (2.0) cm H(2)O in non-obese subjects (p<0.001). The EMGdi increased in the obese group to 24.7 (8.2)%max (p<0.001) but remained the same in non-obese subjects (7.0 (3.4)%max, p = NS). Obese subjects developed intrinsic positive end-expiratory pressure (PEEPi) of 5.3 (3.6) cm H(2)O when supine. Applying continuous positive airway pressure (CPAP) in a subgroup of obese subjects when supine reduced the EMGdi by 40%, inspiratory pressure swings by 25% and largely abolished PEEPi (4.1 (2.7) vs 0.8 (0.4) cm H(2)O, p = 0.009).
  
  
  CONCLUSIONS
  Obese patients have substantially increased neural drive related to BMI and develop PEEPi when supine. CPAP abolishes PEEPi and reduces neural respiratory drive in these patients. These findings highlight the adverse respiratory consequences of obesity and have implications for the clinical management of patients, particularly where the supine posture is required.
authors.affiliation: Chest Unit, King's College London School of Medicine, Denmark Hill, London, UK. joerg.steier@kcl.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Steier
authors.forename: C J
authors.initials: CJ
authors.lastname: Jolley
authors.forename: J
authors.initials: J
authors.lastname: Seymour
authors.forename: M
authors.initials: M
authors.lastname: Roughton
authors.forename: M I
authors.initials: MI
authors.lastname: Polkey
authors.forename: J
authors.initials: J
authors.lastname: Moxham
mesh_terms: D000328:Adult; D015992:Body Mass Index; D045422:Continuous Positive Airway Pressure; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D018467:Positive-Pressure Respiration, Intrinsic / Q000150:complications / Q000503:physiopathology* / Q000517:prevention & control; D011187:Posture; D015656:Respiratory Mechanics / Q000502:physiology*