IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo.
Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that gammadelta T cells limit CD8 T-cell expansion but not the initial proliferation after transfer into lymphopenic recipients. Interleukin-15 (IL-15) produced by and trans-presented on the membrane of the CD11c(+) dendritic cells (DCs) is the key factor that mediates homeostatic competition between CD8 and gammadelta T cells, revealing previously unrecognized IL-15-dependent homeostatic mechanisms between different T-cell subsets in vivo.
Do
Jeong-su
JS
Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA.
Min
Booki
B
D019264:Adoptive Transfer; D000818:Animals; D039521:CD11c Antigen / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D003713:Dendritic Cells / Q000276:immunology*; D016654:Genes, RAG-1; D006706:Homeostasis / Q000276:immunology; D019409:Interleukin-15 / Q000172:deficiency / Q000235:genetics / Q000276:immunology / Q000494:pharmacology / Q000502:physiology*; D008213:Lymphocyte Activation; D008212:Lymphocyte Depletion; D008231:Lymphopenia / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011828:Radiation Chimera; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000172:deficiency; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D053647:Receptors, Interleukin-15 / Q000276:immunology; D011994:Recombinant Proteins / Q000494:pharmacology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000637:transplantation
D039521:CD11c Antigen; D019409:Interleukin-15; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D053647:Receptors, Interleukin-15; D011994:Recombinant Proteins