Effectiveness of topically applied halofuginone in management of subglottic stenosis in rats.
OBJECTIVE
The aim of the study is to ascertain the antifibrotic effect of topically applied halofuginone after acute subglottic injury.


METHODS
After standardized trauma to subglottic area, rats were divided into two groups: the study group that received treatment and the control group that did not. The subjects were treated with topical application of cottonoid soaked in 30 mg/dL halofuginone solution for 5 minutes after subglottic trauma. The larynx specimens were examined histopathologically by light microscopy to assess fibrosis, epithelialization, inflammation, and necrosis.


RESULTS
The fibrosis indexes of the treated group were significantly less than those of the control group (P < 0.05).


CONCLUSIONS
Topically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.
Ertuğrul
Eylem Ertug
EE
ENT Department, Güneydoğu Medical Center, Diyarbakir, Turkey. ertugrul@doctor.com
Cekin
I Engin
IE
Cincik
Hakan
H
Doğru
Salim
S
Güngör
Atila
A
D000287:Administration, Topical; D000818:Animals; D005355:Fibrosis / Q000188:drug therapy / Q000473:pathology; D007829:Laryngostenosis / Q000188:drug therapy* / Q000473:pathology; D010880:Piperidines / Q000008:administration & dosage* / Q000494:pharmacology; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D052999:Quinazolinones / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric
D010880:Piperidines; D011500:Protein Synthesis Inhibitors; D052999:Quinazolinones; C010176:halofuginone