title: All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery.
abstract: Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Kyuri
authors.initials: K
authors.lastname: Lee
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Moon
authors.forename: Yuhan
authors.initials: Y
authors.lastname: Lee
authors.forename: Tae Gwan
authors.initials: TG
authors.lastname: Park
authors.forename: Jinwoo
authors.initials: J
authors.lastname: Cheon
mesh_terms: D045744:Cell Line, Tumor; D005290:Ferric Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D055785:Gene Knockdown Techniques; D020868:Gene Silencing; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000235:genetics; D009842:Oligopeptides / Q000737:chemistry; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000235:genetics; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014162:Transfection
chemical_list: D005290:Ferric Compounds; D005456:Fluorescent Dyes; D009842:Oligopeptides; D034741:RNA, Small Interfering; C000499:ferric oxide; C047981:arginyl-glycyl-aspartic acid