title: Biochip arrays for the discovery of a biomarker surrogate in a phase I/II study assessing a novel anti-metastasis agent.
abstract: OBJECTIVE
  Can biochip arrays identify which individuals with metastatic disease will respond to an anti-metastatic agent?
  
  
  METHODS
  Cytokine and cell adhesion arrays (Randox Ltd) were measured over 1 month in 9 research participants receiving CTCE-9908 in a Phase I/II study.
  
  
  RESULTS
  Research participants with stable disease (n=2) had significantly higher soluble VCAM-1 as compared to those that progressed.
  
  
  CONCLUSIONS
  VCAM-1 measurement early during CTCE-9908 treatment might be used as a surrogate for response.
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada. kavsakp@mcmaster.ca
authors.forename: Peter A
authors.initials: PA
authors.lastname: Kavsak
authors.forename: Matthew
authors.initials: M
authors.lastname: Henderson
authors.forename: Patricia
authors.initials: P
authors.lastname: Moretto
authors.forename: Hal
authors.initials: H
authors.lastname: Hirte
authors.forename: Ken
authors.initials: K
authors.lastname: Evans
authors.forename: Donald
authors.initials: D
authors.lastname: Wong
authors.forename: Walter
authors.initials: W
authors.lastname: Korz
authors.forename: Sebastien J
authors.initials: SJ
authors.lastname: Hotte
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000097:blood; D016207:Cytokines / Q000097:blood; D003710:Demography; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D010455:Peptides / Q000627:therapeutic use*; D040081:Protein Array Analysis / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; C540323:CTCE-9908; D015815:Cell Adhesion Molecules; D016207:Cytokines; D010455:Peptides