title: [Studies on self-microemulsifying drug preparations of total flavones of Hippophae rhamnoides].
abstract: OBJECTIVE
  To develop self-microemulsifying preparations of total flavones of Hippophae Rhamnoides L. (TFH) and the determination method of dissolution.
  
  
  METHODS
  The equilibrium solubility of TFH in different compositions of oils, emulsifier and assistant emulsifier was investigated. The self-microemulsion formula was optimized by constructing the pseudo-ternary phase diagrams of blank SMEDDS determining the self-microemulsifying efficiency and the stability of the SMEDDS. The 2 hours dissolution curve of TFH self-microemulsifying preparations was established. The optimal self-microemulsion formula was composed of MIGLYOL 812 N, Cremophor EL and 1,2-Propylene glycol.
  
  
  RESULTS
  The ratio of them was 0.5:5.7:3.8. The average particle size was 12.1 nm. The dissolution rate at 10 minutes of TFH self-microemulsifying preparation was 131% higher than that of Xinda kang tablets.
  
  
  CONCLUSIONS
  The acquired microemulsion with small particle size is stable. The dissolution rate is evidently improved compared with market dosage forms.
authors.affiliation: Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. rosexie_2004@163.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Xie
authors.forename: Rong
authors.initials: R
authors.lastname: Rong
authors.forename: Guowen
authors.initials: G
authors.lastname: Li
authors.forename: Xiurong
authors.initials: X
authors.lastname: Yuan
authors.forename: Jianying
authors.initials: J
authors.lastname: Wang
mesh_terms: D002138:Calibration; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D004655:Emulsions; D047309:Flavones / Q000737:chemistry*; D031281:Hippophae / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013607:Tablets
chemical_list: D004365:Drugs, Chinese Herbal; D004655:Emulsions; D047309:Flavones; D012997:Solvents; D013607:Tablets