Numb--from flies to humans.
Numb carries the distinction of being the first molecule discovered to influence cell fate by being asymmetrically segregated during cell division. Originally identified from studies in Drosophila, further work has since demonstrated the importance of Numb in mammalian and, in particular, human systems, from diverse fields such as developmental neurobiology to cancer biology and neurodegenerative disease. This review surveys the body of knowledge concerning Numb, and discusses the relevance of Numb to human biology and disease.
Yan
Benedict
B
Department of Pathology, National University Hospital and Yong Loo Lin's School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Republic of Singapore. tranceblues@gmail.com
D000818:Animals; D002455:Cell Division / Q000502:physiology; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007605:Juvenile Hormones / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000503:physiopathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism
D029721:Drosophila Proteins; D007605:Juvenile Hormones; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C113026:NUMB protein, human; D020033:Protein Isoforms; C060606:numb protein, Drosophila