title: Respiratory modulation in response to high-frequency airway occlusion delivered during inspiration or expiration.
abstract: To investigate whether 30 breaths performed against a high-frequency airway occlusion stimulus modulates ventilatory control both within-phase (within the phase of breathing that the stimulus was presented) and opposite-phase (in the opposite-phase of breathing to that in which the stimulus was presented) of the respiratory cycle. Ten healthy subjects (3 female, 7 male; 22-44 years old) completed 30 breaths prior to and following 30 inspirations or expirations against a high-frequency occlusion stimulus (youbreathe, Exoscience Ltd., London, UK), pressure-matched resistive loading or resting tidal breathing (no load) presented in a random order. The major findings from this study were that inspiratory-only high-frequency occlusion caused a significant augmentation in peak inspiratory airflow and shortening of expiratory time not observed during corresponding resistance. There were no residual effects of any intervention upon any measured ventilatory variables. High-frequency airway occlusion modulates ventilation both within-phase and in the opposite-phase, effects which are absent following resistive loaded breathing.
authors.affiliation: Faculty of Engineering, Science and the Built Environment, Sport and Exercise Science Research Centre, London South Bank University, London SE1 0AA, UK. sumnerdp@lsbu.ac.uk
authors.forename: David Paul
authors.initials: DP
authors.lastname: Sumners
authors.forename: Steven P
authors.initials: SP
authors.lastname: Hunter
authors.forename: David A
authors.initials: DA
authors.lastname: Green
mesh_terms: D000328:Adult; D000403:Airway Resistance / Q000502:physiology*; D045853:Exhalation / Q000502:physiology; D005260:Female; D006801:Humans; D001239:Inhalation / Q000502:physiology; D008297:Male; D011312:Pressure; D012123:Pulmonary Ventilation / Q000502:physiology; D012119:Respiration; D015656:Respiratory Mechanics / Q000502:physiology*; D014732:Vibration; D055815:Young Adult