Crown-capped imidacloprid: a novel design and insecticidal activity.
Imidacloprid (IMI) derivatives conjugated with benzo-15-crown-5 and benzo-18-crown-6 structures, applied for the first time to explore novel insecticidal molecule, elicited strong excitatory toxic signs to the house flies and stunningly exhibited three to five times higher insecticidal activity than that of the parent IMI, yet the two benzo-crown structures themselves had no effect.
Kagabu
Shinzo
S
Department of Chemistry, Faculty of Education, Gifu University, Gifu, Japan. kagabus@gifu-u.ac.jp
Takagi
Masaru
M
Ohno
Ikuya
I
Mikawa
Tsuyoshi
T
Miyamoto
Toru
T
D000818:Animals; D043844:Crown Ethers / Q000737:chemistry; D015195:Drug Design; D005260:Female; D006793:Houseflies / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D043844:Crown Ethers; D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; C042148:15-crown-5; C082359:imidacloprid; C015762:18-crown-6