[Inflammation, adipokines and obesity].
In obese subjects, there is a "low grade" inflammatory state characterized by the moderate but chronic systemic rise of a panel of molecules (adipokines), which carry out, in addition to pro- or anti-inflammatory actions, several immune or metabolic functions, associated with a macrophagic infiltration in adipose tissue. These two factors provide a better understanding of the pathophysiology of obesity and its potential metabolic, cardiovascular or hepatic complications. A small or even moderate reduction of weight significantly reduces circulating inflammatory markers, modulates adipose tissue profile of inflammatory genes and the risks associated with obesity.
Clément
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Service de nutrition, pôle d'endocrinologie, hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, U872 (équipe 7), Inserm, centre de recherche des Cordeliers, université Pierre-et-Marie-Curie Paris-6, 75006 Paris, France. karine.clement@psl.aphp.fr
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D054392:Adipokines / Q000502:physiology*; D000273:Adipose Tissue / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000503:physiopathology*; D008264:Macrophages / Q000378:metabolism / Q000502:physiology; D009765:Obesity / Q000150:complications / Q000178:diet therapy / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D012307:Risk Factors; D015431:Weight Loss
D054392:Adipokines