Barrier immunity and IL-17.
CD4+ T(H)17 cells display a featured role in barrier immunity. This effector population of T cells is important for clearance of microorganisms but can also promote autoimmunity at barrier sites. Recent work has indicated that these effector cells share a pathway with CD4+ regulatory T cells (T(R) cells) that also have a critical function in barrier protection and immune regulation. The development and function of T(H)17 cells, and their relationship with T(R) cells are discussed.
Marks
Benjamin R
BR
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
Craft
Joe
J
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D018928:Immunity, Mucosal; D007239:Infections / Q000276:immunology; D020381:Interleukin-17 / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism*; D008168:Lung / Q000276:immunology* / Q000473:pathology; D015398:Signal Transduction; D012867:Skin / Q000276:immunology* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D015533:Transcriptional Activation
D020381:Interleukin-17