[Two cases of recurrent oral cancer responding to radiochemotherapy with selective intra-arterial infusion of nedaplatin].
Nedaplatin, a cisplatin derivative, has been reported to be an effective anti-tumor agent for head and neck cancer. We experienced two patients with advanced recurrent oral cancers who received combination therapy of intra-arterial nedaplatin infusion and radiation therapy, and tumoricidal effects were obtained in these cases. At the end of 3 courses, a partial response(PR)was obtained with regression of the tumor in the first case, and FDGPET showed a complete regression of recurrent tumor for a complete response(CR)in another case. This combination therapy is quite safe and effective for the treatment of advanced oral cancers.
Yamashita
Yoshio
Y
Department of Oral and Maxillofacial Surgery, Saga Medical School.
Kuroda
Yoshimi
Y
Yamamoto
Tatsuya
T
Goto
Masaaki
M
D000368:Aged; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D009944:Organoplatinum Compounds / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D012008:Recurrence; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
D009944:Organoplatinum Compounds; C053989:nedaplatin