title: Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation.
abstract: Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.
authors.affiliation: Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Christian
authors.initials: C
authors.lastname: Oudshoorn
authors.forename: Tischa J M
authors.initials: TJ
authors.lastname: van der Cammen
authors.forename: Marion E T
authors.initials: ME
authors.lastname: McMurdo
authors.forename: Johannes P T M
authors.initials: JP
authors.lastname: van Leeuwen
authors.forename: Edgar M
authors.initials: EM
authors.lastname: Colin
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D019587:Dietary Supplements; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism; D014807:Vitamin D / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000378:metabolism*
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D002118:Calcium