title: [Effects of curcumin on malondialdehyde and c-fos protein in hypoxia ischemia brain tissue in rats].
abstract: OBJECTIVE
  To explore the effects of curcumin on the content of malondialdehyde (MDA) and the expression level of c-fos protein following hypoxia ischemia brain damage (HIBD) in rats.
  
  
  METHODS
  Sprague-Dauley (SD) rats were randomly divided into four groups as the following: sham group, hypoxia ischemia brain damage group, curcumin group and solvent control group. The content of MDA in the brain was measured by colorimetry. The expression level of c-fos protein in the cortex tissue was detected by immunohistochemistry. Morphologic and structural changes of neuron cells of the cortex were observed by electron microscopy.
  
  
  RESULTS
  The content of MDA was clearly lower in curcumin group than that in the other groups at the same time after HIBD. The expression level of c-fos protein was higher in the curcumin group than that in the other groups (P<0.05). Electron microscopy showed that the morphologic and structural changes of neuron cells of cortex in the curcumin group were reduced.
  
  
  CONCLUSIONS
  Curcumin could significantly decrease the content of MDA, increase the expression level of c-fos protein and reduce the damage of the neuron cells.
authors.affiliation: Department of Forensic Medicine, Wenzhou Medical College, Wenzhou 325035, China. yyzdxno@163.com
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Zheng
authors.forename: Lin-sheng
authors.initials: LS
authors.lastname: Yu
authors.forename: Yi-gu
authors.initials: YG
authors.lastname: Zhang
authors.forename: Guang-hua
authors.initials: GH
authors.lastname: Ye
authors.forename: Ji-pu
authors.initials: JP
authors.lastname: Yi
mesh_terms: D000818:Animals; D003474:Curcumin / Q000494:pharmacology*; D049429:Forensic Pathology; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018696:Neuroprotective Agents; D016760:Proto-Oncogene Proteins c-fos; D008315:Malondialdehyde; D003474:Curcumin