Magic spot: (p) ppGpp.
Guanosine 5'-(tri)diphosphate, 3'-diphosphate [(p) ppGpp] is a small nucleic acid that helps bacteria survive in limited environments. Gene chip shows that (p) ppGpp is a global transcription-regulator of genes related to important bacterial metabolic processes. Therefore, more attention should be focused on the molecular mechanisms of (p) ppGpp, as it is the foundation to understanding how bacteria adapt to extreme circumstances through the stringent response.
Wu
Jun
J
Institute of Modern Biopharmaceuticals, School of Life Sciences, Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, Southwest University, Chongqing, China.
Xie
Jianping
J
D000222:Adaptation, Physiological; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006158:Guanosine Pentaphosphate / Q000737:chemistry / Q000378:metabolism*; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D008025:Ligases / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D011487:Protein Conformation; D011755:Pyrophosphatases / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D007527:Isoenzymes; D010940:Plant Proteins; D006158:Guanosine Pentaphosphate; D012321:DNA-Directed RNA Polymerases; C027627:guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase; D011755:Pyrophosphatases; D008025:Ligases; C028812:guanosine 3',5'-polyphosphate synthetases