Multicell simulations of development and disease using the CompuCell3D simulation environment.
Mathematical modeling and computer simulation have become crucial to biological fields from genomics to ecology. However, multicell, tissue-level simulations of development and disease have lagged behind other areas because they are mathematically more complex and lack easy-to-use software tools that allow building and running in silico experiments without requiring in-depth knowledge of programming. This tutorial introduces Glazier-Graner-Hogeweg (GGH) multicell simulations and CompuCell3D, a simulation framework that allows users to build, test, and run GGH simulations.
Swat
Maciej H
MH
Biocomplexity Institute and Department of Physics, Indiana University, Bloomington, USA.
Hester
Susan D
SD
Balter
Ariel I
AI
Heiland
Randy W
RW
Zaitlen
Benjamin L
BL
Glazier
James A
JA
D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D015509:Developmental Biology; D004194:Disease; D006801:Humans; D021621:Imaging, Three-Dimensional; D008433:Mathematics; D008962:Models, Theoretical; D011381:Programming Languages; D012984:Software