title: Serum estradiol levels during controlled ovarian hyperstimulation influence the pregnancy outcome of in vitro fertilization in a concentration-dependent manner.
abstract: OBJECTIVE
  To determine an optimal serum E(2) level on the day of hCG administration in controlled ovarian hyperstimulation (COH) during IVF-ET without compromising pregnancy outcome.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Large urban medical center.
  
  
  METHODS
  Data of 455 cycles of fresh IVF-ET with COH.
  
  
  METHODS
  Serum E(2) levels on the day of hCG administration were categorized into five groups: group A (<1000 pg/mL), group B (1000-2000 pg/mL), group C (2000-3000 pg/mL), group D (3000-4000 pg/mL), and group E (>4000 pg/mL).
  
  
  METHODS
  Serum E(2) levels, number of oocytes retrieved, pregnancy outcomes.
  
  
  RESULTS
  Of 455 cycles, 148 (32.5%) cycles resulted in clinical pregnancy. The implantation rate was 12.2%, and the delivery rate was 18.7%. The number of oocytes obtained increased with increasing serum E(2) levels. The pregnancy rate gradually increased from group A to D as E(2) levels increased but decreased in group E. In women <38 years, the IVF-ET outcomes were similar to those of total patients. However, in women >/=38 years old, pregnancy and delivery rates were higher in group C than in other groups.
  
  
  CONCLUSIONS
  These results show that serum E(2) levels have a concentration-dependent effect on the pregnancy outcome, suggesting an optimal range of E(2) level for achieving a successful pregnancy. This optimal range of serum E(2) level in women is age dependent: 3000-4000 pg/mL for women <38 years and 2000-3000 pg/mL for women >/=38 years.
authors.affiliation: Center for Reproductive Medicine, Good Moonhwa Hospital, Busan 601-062, South Korea.
authors.forename: Bo Sun
authors.initials: BS
authors.lastname: Joo
authors.forename: Sea Hee
authors.initials: SH
authors.lastname: Park
authors.forename: Byeong Min
authors.initials: BM
authors.lastname: An
authors.forename: Kyung Sue
authors.initials: KS
authors.lastname: Kim
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Moon
authors.forename: Hwa Sook
authors.initials: HS
authors.lastname: Moon
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D010064:Embryo Implantation / Q000187:drug effects / Q000502:physiology; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data; D006801:Humans; D007231:Infant, Newborn; D008597:Menstrual Cycle; D054315:Oocyte Retrieval / Q000379:methods; D010060:Ovulation / Q000187:drug effects / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D004958:Estradiol