Ubiquitin connects with planar cell polarity.
Planar cell polarity (PCP) regulates the orientation of cells in epithelia and of mesenchymal cells during gastrulation. In this issue, Narimatsu et al. (2009) report that the Smurf E3 ubiquitin ligases are required for localized protein degradation of a core PCP factor to generate cellular asymmetry.
Mlodzik
Marek
M
Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA. marek.mlodzik@mssm.edu
D000818:Animals; D016764:Cell Polarity; D003051:Cochlea / Q000196:embryology*; D004330:Drosophila; D054262:Gastrulation; D051379:Mice; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014921:Wings, Animal / Q000196:embryology
D044767:Ubiquitin-Protein Ligases