Mechanism of ribosome assisted protein folding: a new insight into rRNA functions.
The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.
Samanta
Dibyendu
D
Department of Biophysics, Molecular Biology and Genetics, University College of Science, Kolkata 700009, India. dsamanta@aecom.yu.edu
Das
Anindita
A
Bhattacharya
Arpita
A
Basu
Arunima
A
Das
Debasis
D
DasGupta
Chanchal
C
D001419:Bacteria / Q000378:metabolism*; D003461:Crystallography; D004926:Escherichia coli / Q000378:metabolism; D009690:Nucleic Acid Conformation; D010458:Peptidyl Transferases / Q000378:metabolism*; D017510:Protein Folding; D012338:RNA, Ribosomal, 23S / Q000737:chemistry / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*
D012338:RNA, Ribosomal, 23S; D010458:Peptidyl Transferases