title: The accuracy of frozen section analysis at hysterectomy in patients with atypical endometrial hyperplasia.
abstract: OBJECTIVE
  To evaluate the accuracy of frozen section analysis in patients with atypical endometrial hyperplasia.
  
  
  METHODS
  Women who underwent hysterectomy with frozen section analysis for atypical endometrial hyperplasia were identified. Frozen section evaluation aimed to give information about the presence of malignancy. Also, myometrial or cervical involvement was assessed in cases with malignancy to reveal the need for staging. Final pathological evaluation results were compared with intraoperative frozen section analyses.
  
  
  RESULTS
  Twelve patients (34.3%) had endometrial cancer on final pathologic examination and eight required a staging procedure due to either myometrial invasion or cervical involvement; 75% of patients with endometrial cancer were successfully detected by frozen section analysis. Moreover, among women with cancer, frozen section examination revealed 75% of cases who required surgical staging.
  
  
  CONCLUSIONS
  Frozen section analysis of hysterectomy specimens in patients with atypical endometrial hyperplasia is necessary to determine the presence of cancer and the need for surgical staging.
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Gynaecological Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey. csalman@hacettepe.edu.tr
authors.forename: M C
authors.initials: MC
authors.lastname: Salman
authors.forename: A
authors.initials: A
authors.lastname: Usubutun
authors.forename: N U
authors.initials: NU
authors.lastname: Dogan
authors.forename: K
authors.initials: K
authors.lastname: Yuce
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004714:Endometrial Hyperplasia / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D005629:Frozen Sections; D006801:Humans; D007044:Hysterectomy; D007430:Intraoperative Care; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D021701:Sentinel Lymph Node Biopsy