title: Low-molecular-weight dendrons for DNA binding and release by reduction-triggered degradation of multivalent interactions.
abstract: Losing the grip: The synthesis of multivalent low-molecular-weight dendrons with lysine branching units coupled to disulfide-linked spermine surface groups is described. It is furthermore demonstrated that the dendrons bind DNA with good affinity (see image), but are also able to release the DNA in a reductive environment.
authors.affiliation: Department of Engineering Physics, Helsinki University of Technology, P.O. BOX 2200, 02015 HUT, Espoo, Finland. m.kostiainen@science.ru.nl
authors.forename: Mauri A
authors.initials: MA
authors.lastname: Kostiainen
authors.forename: Henna
authors.initials: H
authors.lastname: Rosilo
mesh_terms: D004247:DNA / Q000737:chemistry*; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008239:Lysine / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008970:Molecular Weight; D013096:Spermine / Q000737:chemistry
chemical_list: D050091:Dendrimers; D013096:Spermine; D004247:DNA; D008239:Lysine