title: Communication routes between intracranial spaces and inner ear: function, pathophysiologic importance and relations with inner ear diseases.
abstract: OBJECTIVE
  There exist 3 communication routes between the intracranial space and the inner ear, the vestibular aqueduct, the cochlear aqueduct, and the internal auditory canal. They possess a key role in inner ear pressure regulation and fluid homeostasis and are related to inner ear diseases.
  
  
  METHODS
  Relevant literature was reviewed, and the current knowledge of the anatomy, physiologic importance, and relations to inner ear diseases were described. Pathologic communication routes such as semicircular canal dehiscence syndrome were highlighted as well.
  
  
  CONCLUSIONS
  Abnormalities in all 3 communication routes may predispose or be the cause of distinct inner ear pathologic condition and involved in other cochlear and vestibular syndromes, in which their role is not completely clear. The increasing knowledge of the underlying mechanisms encourages promising approaches for possible intervention in the future.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Tübingen, Germany. ciuman.raphael@cityweb.de
authors.forename: Raphael R
authors.initials: RR
authors.lastname: Ciuman
mesh_terms: D003052:Cochlear Aqueduct / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology; D007758:Ear, Inner / Q000033:anatomy & histology* / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007759:Labyrinth Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D012665:Semicircular Canals / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014723:Vestibular Aqueduct / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology