Cutaneous infection caused by Macrophomina phaseolina in a child with acute myeloid leukemia.
We report a case of Macrophomina phaseolina skin infection in an immunocompromised child with acute myeloid leukemia, which was treated successfully with posaconazole without recurrence after a hematopoietic stem cell transplant. The fungus was identified by DNA sequencing using both the internal transcribed spacer and D1/D2 region of the 28S ribosomal DNA gene.
Srinivasan
Ashok
A
Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 260, Memphis, TN 38105, USA. ashok.srinivasan@stjude.org
Wickes
Brian L
BL
Romanelli
Anna M
AM
Debelenko
Larisa
L
Rubnitz
Jeffrey E
JE
Sutton
Deanna A
DA
Thompson
Elizabeth H
EH
Fothergill
Annette W
AW
Rinaldi
Michael G
MG
Hayden
Randall T
RT
Shenep
Jerry L
JL
D000935:Antifungal Agents / Q000627:therapeutic use; D001203:Ascomycota / Q000302:isolation & purification*; D002648:Child; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003881:Dermatomycoses / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012867:Skin / Q000473:pathology; D014230:Triazoles / Q000627:therapeutic use
D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D014230:Triazoles; C101425:posaconazole