title: [Extreme prematurity: comparison of outcome at 5 years depending on gestational age below or above 26 weeks].
abstract: OBJECTIVE
  Is it reasonable to care for children born under 26 gestational weeks (GW)? To answer this question, we compared outcome at 5 years of 2 groups of children:less or equal to 25 GW+6 days (group 1) and 26-27 GW+6 days (group 2).
  
  
  METHODS
  Retrospective study on extremely preterm children hospitalized in our center between 1999 and 2001. Perinatal data were obtained from medical reports. Five-year outcome was evaluated by questionnaire sent to Centers for Early Medicosocial Intervention, pediatricians or the child's parents. The children were classified according to their disability: none, minor or major. Progression was considered favorable if the child survived with or without minor disability and unfavorable if the child had died or had major disability.
  
  
  RESULTS
  One hundred and sixty-six preterm babies were recorded. In group 1 (n=63), mortality was higher (58% vs 29%; p=0.0002), a neurologic cause was often responsible for death (36% vs 19%; p=0.018), a high level of intracranial hemorrhage was more frequent (35% vs 19%; p=0.002), and a decision to stop healthcare more often made (35% vs 18%; p=0.01) than in group 2 (n=103). Among the 99 survivors, 78 were being followed up at 5 years of age. In terms of disability, no difference was observed between group 1 (n=21) and group 2 (n=57). Including deaths, the risk for unfavorable progression was higher in group 1 (64% vs 41%; p=0.008).
  
  
  CONCLUSIONS
  The progression of under 26-GW preterm babies is more often unfavorable than the progression of babies born 26-27 GW+6 days. However, given the low number of patients, no significant difference was made concerning the prognosis at 5 years between the survivors of the 2 groups.
authors.affiliation: Institut de puériculture et de périnatalogie, 26, boulevard Brune, 75014 Paris, France. fanny.autret@free.fr
authors.forename: F
authors.initials: F
authors.lastname: Autret
authors.forename: F
authors.initials: F
authors.lastname: Kieffer
authors.forename: A
authors.initials: A
authors.lastname: Tasseau
authors.forename: V
authors.initials: V
authors.lastname: Rigourd
authors.forename: D
authors.initials: D
authors.lastname: Valleur
authors.forename: M
authors.initials: M
authors.lastname: Voyer
authors.forename: J-F
authors.initials: JF
authors.lastname: Magny
mesh_terms: D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality; D002423:Cause of Death; D002547:Cerebral Palsy / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D019988:Children with Disabilities / Q000706:statistics & numerical data*; D004453:Echoencephalography; D005260:Female; D005500:Follow-Up Studies; D005602:France; D005865:Gestational Age; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D019102:Infant, Very Low Birth Weight; D020300:Intracranial Hemorrhages / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality; D007859:Learning Disabilities / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality; D007969:Leukomalacia, Periventricular / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous; D017063:Outcome Assessment, Health Care; D012178:Retinopathy of Prematurity / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D028761:Withholding Treatment / Q000706:statistics & numerical data