A rare astrocytic tumor with rhabdoid features.
We report an extremely rare tumor presenting with rhabdoid features in the left temporoparietal lobe near the trigone in an 18-year-old Japanese man. This tumor mainly consisted of medium to large round cells that proliferated diffusely and incoherently with a scant extracellular matrix. These tumor cells had an eccentric nucleus and an eosinophilic cytoplasm containing inclusion bodies and bundles of intermediate filaments. The nuclei of these cells were vesicular with prominent nucleoli. This tumor had an area appearing to be diffuse astrocytoma peripherally and lacked a primitive neuroectodermal tumor component, a mesenchymal component, and epithelial differentiation. INI expression, which is not observed in atypical teratoid/ rhabdoid tumor (AT/RT), was found in this tumor. From these findings, we concluded that this tumor was not AT/RT but an astrocytic tumor with rhabdoid features. We also concluded that the tumor cells exhibiting rhabdoid features had secondarily arisen from the peripheral area presenting an appearance of diffuse astrocytoma.
Nagai
Shoichi
S
Department of Neurosurgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. shoichi@chive.ocn.ne.jp
Kurimoto
Masanori
M
Ishizawa
Shin
S
Hayashi
Nakamasa
N
Hamada
Hideo
H
Kamiyama
Hironaga
H
Endo
Shunro
S
D000293:Adolescent; D001254:Astrocytoma / Q000473:pathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D005109:Extracellular Matrix / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures; D010296:Parietal Lobe / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000523:psychology; D018335:Rhabdoid Tumor / Q000473:pathology* / Q000601:surgery; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery; D013724:Teratoma / Q000473:pathology; D014057:Tomography, X-Ray Computed