title: Event-related oscillations in mice: effects of stimulus characteristics.
abstract: Event-related oscillations (EROs) are rhythmic changes that are evoked by sensory and/or cognitive processes that influence the dynamics of the EEG. EROs are estimated by a decomposition of the EEG signal into phase and magnitude information for a range of frequencies and then changes in those frequencies are characterized over a millisecond time scale with respect to task events. EROs have been demonstrated to be sensitive measures of both normal and abnormal cognitive functioning in humans but have not been fully described in mice. The results of these studies demonstrate that EROs can be generated in cortical sites in mice in the delta, theta, alpha/beta frequency ranges in response to auditory stimuli. Oscillations in the 7.5-40 Hz frequencies were significantly affected in the 0-50 ms time range in response to differences in tone frequency. Whereas, changes in tone loudness produced changes in oscillations in the 7.5-40 Hz frequencies in the 350-800 ms range. No significant changes in EROs were found to differences in tone probability. These studies suggest that EROs are an electrophysiological assay sensitive to tone characteristics and as such may be suitable for the exploration of the effects of genetic or neuropharmacological manipulations on neurosensory processing in mice.
authors.affiliation: The Scripps Research Institute, Molecular and Integrative Neuroscience Department, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. cindye@scripps.edu
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Ehlers
authors.forename: Jose R
authors.initials: JR
authors.lastname: Criado
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000704:Analysis of Variance; D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D001683:Biological Clocks / Q000235:genetics / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011571:Psychoacoustics; D011930:Reaction Time; D013997:Time Factors