title: Isoniazid induced gynaecomastia: a case report.
abstract: Gynaecomastia due to anti-tubercular chemotherapy is a rare side effect. Isoniazid causing breast tissue enlargement has been very rarely reported. We report a 60-year old, male patient of Pulmonary Tuberculosis who was started on antituberculous treatment (ATT) with rifampicin (R), isoniazid (H), ethambutol (E) and pyrazinamide (Z) together for initial two months and R, H & E thereon. After five months of initiation of treatment, while receiving RHE, he developed painful bilateral gynaecomastia. Isoniazid was stopped and patient was continued on R & E till completion of the treatment up to nine months. After stopping isoniazid, his breast swelling subsided to some extent and became non-tender. Follow up, at six months, after stopping the course of treatment, patient was asymptomatic except for slight bilateral non-tender breast enlargement.
authors.affiliation: Department of Pulmonary Medicine, Chhatrapati Sahuji Maharaj Medical University, Lucknow, Uttar Pradesh. rgarg70@rediffmail.com
authors.forename: R
authors.initials: R
authors.lastname: Garg
authors.lastname: Vaibhav
authors.forename: Sumit
authors.initials: S
authors.lastname: Mehra
authors.forename: R
authors.initials: R
authors.lastname: Prasad
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000008:administration & dosage; D006177:Gynecomastia / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008327:Mammography; D008875:Middle Aged; D011718:Pyrazinamide / Q000008:administration & dosage; D012293:Rifampin / Q000008:administration & dosage; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin