title: Auditory processing disorder in perisylvian syndrome.
abstract: We hypothesized that the processing of auditory information by the perisylvian polymicrogyric cortex may be different from the normal cortex. To characterize the auditory processing in bilateral perisylvian syndrome, we examined ten patients with perisylvian polymicrogyria (Group I) and seven control children (Group II). Group I was composed by four children with bilateral perisylvian polymicrogyria and six children with bilateral posterior perisylvian polymicrogyria. The evaluation included neurological and neuroimaging investigation, intellectual quotient and audiological assessment (audiometry and behavior auditory tests). The results revealed a statistically significant difference between the groups in the behavioral auditory tests, such as, digits dichotic test, nonverbal dichotic test (specifically in right attention), and random gap detection/random gap detection expanded tests. Our data showed abnormalities in the auditory processing of children with perisylvian polymicrogyria, suggesting that perisylvian polymicrogyric cortex is functionally abnormal. We also found a correlation between the severity of our auditory findings and the extent of the cortical abnormality.
authors.affiliation: Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil.
authors.forename: Mirela
authors.initials: M
authors.lastname: Boscariol
authors.forename: Vera Lúcia
authors.initials: VL
authors.lastname: Garcia
authors.forename: Catarina Abraão
authors.initials: CA
authors.lastname: Guimarães
authors.forename: Maria Augusta
authors.initials: MA
authors.lastname: Montenegro
authors.forename: Simone Rocha Vasconcelos
authors.initials: SR
authors.lastname: Hage
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
authors.forename: Marilisa Mantovani
authors.initials: MM
authors.lastname: Guerreiro
mesh_terms: D000293:Adolescent; D001299:Audiometry; D001307:Auditory Perception / Q000502:physiology; D001308:Auditory Perceptual Disorders / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000002:abnormalities*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D054220:Malformations of Cortical Development / Q000473:pathology / Q000503:physiopathology; D009483:Neuropsychological Tests; D013577:Syndrome