title: Negative influence of paternal age on clinical intracytoplasmic sperm injection cycle outcomes in oligozoospermic patients.
abstract: OBJECTIVE
  To evaluate the effect of male age on clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles, according to sperm concentration.
  
  
  METHODS
  Retrospective, observational study.
  
  
  METHODS
  Assisted reproduction center.
  
  
  METHODS
  The study included 1,024 couples undergoing ICSI cycles with fresh spermatozoa.
  
  
  METHODS
  The influence of paternal age on ICSI outcomes of oligozoospermic and normozoospermic patients was evaluated.
  
  
  METHODS
  Rates of high-quality embryos, pregnancy, implantation, and miscarriage were evaluated through linear logistic regression analyses.
  
  
  RESULTS
  When the sperm concentration was abnormal, paternal age influenced implantation (regression coefficient value = -0.7009) and pregnancy rates (odds ratio = 0.95, 95% confidence interval 0.91-0.99). However, in normozoospermic patients, no influence of paternal age was observed on implantation (regression coefficient value = 0.0566) or pregnancy rates (odds ratio = 1.00, 95% confidence interval 0.97-1.03).
  
  
  CONCLUSIONS
  For couples in which the men are oligozoospermic, the implantation rate could be impaired by increased paternal age. In these couples, the chance of pregnancy decreased 5% for each year of paternal age. When men are normozoospermic, this effect is not observed.
authors.affiliation: Sapientiae Institute, Educational and Research Center in Assisted Reproduction, São Paulo, Brazil.
authors.forename: Renata Cristina
authors.initials: RC
authors.lastname: Ferreira
authors.forename: Daniela Paes de Almeida Ferreira
authors.initials: DP
authors.lastname: Braga
authors.forename: Tatiana Carvalho de Souza
authors.initials: TC
authors.lastname: Bonetti
authors.forename: Fabio Firmbach
authors.initials: FF
authors.lastname: Pasqualotto
authors.forename: Assumpto
authors.initials: A
authors.lastname: Iaconelli
authors.forename: Edson
authors.initials: E
authors.lastname: Borges
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology; D000328:Adult; D001755:Blastocyst / Q000166:cytology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000175:diagnosis / Q000628:therapy*; D010331:Paternal Age; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D011786:Quality Control; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data; D016896:Treatment Outcome