Linker immobilization of protein and oligonucleotide on indium-tin-oxide for detection of probe-target interactions by Kelvin physics.
This work describes a label-free microarray analysis technique capable of detecting biomolecule target interactions with probes being anchored with a new linker-diluent system on indium-tin-oxide. The method is based on the differential work function characteristics of the substrate measured by a scanning Kelvin nanoprobe in terms of contact potential difference signals.
Saoud
Marwan
M
Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6.
Blaszykowski
Christophe
C
Ballantyne
Scott M
SM
Thompson
Michael
M
D007204:Indium / Q000737:chemistry*; D036103:Nanotechnology; D040081:Protein Array Analysis / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D017971:Tin Compounds / Q000737:chemistry*
D011506:Proteins; D017971:Tin Compounds; D007204:Indium; C045358:stannic oxide