title: Calcium aluminate coated and uncoated free form fabricated CoCr implants: a comparative study in rabbit.
abstract: The purpose of this study was to compare the integration in bone of uncoated free form fabricated cobalt chromium (CoCr) implants to the same implant with a calcium aluminate coating. The implants of cylindrical design with a pyramidal surface structure were press-fit into the limbs of New Zealand white rabbits. After 6 weeks, the rabbits were sacrificed, and samples were retrieved and embedded. Ground sections were subjected to histological analysis and histomorphometry. The section counter part was used for preparing an electron transparent transmission electron microscopy sample by focused ion beam milling. Calcium aluminate dip coating provided a significantly greater degree of bone contact than that of the native CoCr. The gibbsite hydrate formed in the hardening reaction of the calcium aluminate was found to be the exclusive crystalline phase material in direct contact with bone.
authors.affiliation: Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. anders.palmquist@biomaterials.gu.se
authors.forename: A
authors.initials: A
authors.lastname: Palmquist
authors.forename: T
authors.initials: T
authors.lastname: Jarmar
authors.forename: L
authors.initials: L
authors.lastname: Hermansson
authors.forename: L
authors.initials: L
authors.lastname: Emanuelsson
authors.forename: A
authors.initials: A
authors.lastname: Taylor
authors.forename: M
authors.initials: M
authors.lastname: Taylor
authors.forename: H
authors.initials: H
authors.lastname: Engqvist
authors.forename: P
authors.initials: P
authors.lastname: Thomsen
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry*; D000818:Animals; D001842:Bone and Bones / Q000502:physiology / Q000648:ultrastructure; D017610:Calcium Compounds / Q000737:chemistry*; D002857:Chromium / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D005260:Female; D020007:Implants, Experimental; D008422:Materials Testing; D016348:Osseointegration; D010012:Osteogenesis; D011475:Prosthesis Failure; D011817:Rabbits; D011897:Random Allocation; D013499:Surface Properties
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D020099:Coated Materials, Biocompatible; D002857:Chromium; C035219:calcium aluminate; D003035:Cobalt