GSTM1, GSTM3 and GSTT1 gene variants and risk of benign prostate hyperplasia in North India.
Glutathione S-transferases (GSTs) play an important role in detoxification of various toxic compounds like carcinogens in cigarette smoke and tobacco by conjugating to toxic compounds and inactivating their hazardous effect. Variation in Glutathione S-Transferases (GSTs) genes may alter the catalytic efficiency of GST isoenzymes leading to potential increase in cancer susceptibility due to various carcinogens. We therefore, investigated association of GSTM1, GSTM3 and GSTT1 variants with susceptibility to benign prostate hyperplasia (BPH) and cigarette, tobacco chewing and alcohol consumption as confounding factors in 141 BPH and 184 healthy controls. Results showed increased risk for BPH susceptibility in patients with GSTM1 null genotype (OR-2.03, p = 0.013) and smoking (OR-3.12, p = 0.028), tobacco chewing (OR-2.54, p = 0.039) and alcohol habits (OR-3.39, p = 0.010). Null genotype of GSTM1 with cigarette, tobacco and alcohol habits predisposed increased risk for BPH.
Mittal
Rama Devi
RD
Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. ramamittal@yahoo.com
Kesarwani
Pravin
P
Singh
Ranjana
R
Ahirwar
Dinesh
D
Mandhani
Anil
A
D000428:Alcohol Drinking; D016022:Case-Control Studies; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D012907:Smoking; D014030:Tobacco, Smokeless
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C483009:GSTM3 protein, human