Molecular aspects of tumour hypoxia.
Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its critical role in radio- and chemoresistance and its significance as an adverse prognostic factor have been well established over the last decades. On a cellular level, hypoxia evokes a complex molecular response with a central role for the HIF-1 pathway. The cellular processes under control of HIF-1 contain important prognostic information and comprise potential candidates for directing hypoxia-modifying therapies. This review will provide an overview of the current knowledge on the molecular aspects of tumour hypoxia and the link to clinical practice.
Rademakers
Saskia E
SE
Department of Radiation Oncology, 874 Radboud University Nijmegen Medical Centre, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands.
Span
Paul N
PN
Kaanders
Johannes H A M
JH
Sweep
Fred C G J
FC
van der Kogel
Albert J
AJ
Bussink
Johan
J
D016503:Drug Delivery Systems; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy / Q000209:etiology*; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D011379:Prognosis
D051793:Hypoxia-Inducible Factor 1