title: Monte Carlo modelling of the influence of boron microdistribution on BNCT microdosimetry.
abstract: The ion transport Monte Carlo code SRIM has been used to calculate single event lineal energy spectra for the products of the boron-neutron capture reaction in a water-based medium. The event spectra have been benchmarked against spectra measured with a boron-loaded tissue-equivalent proportional counter (TEPC). Agreement is excellent and supports the use of Monte Carlo methods in understanding the influence of boron delivery on the effectiveness of boron-neutron capture therapy (BNCT).
authors.affiliation: School of Medicine, Swansea University, UK. r.p.hugtenburg@swansea.ac.uk
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hugtenburg
authors.forename: Adam E R
authors.initials: AE
authors.lastname: Baker
authors.forename: Stuart
authors.initials: S
authors.lastname: Green
mesh_terms: D001895:Boron / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000706:statistics & numerical data*; D006371:Helium / Q000528:radiation effects; D006801:Humans; D018499:Linear Energy Transfer; D008094:Lithium / Q000528:radiation effects; D009010:Monte Carlo Method; D009369:Neoplasms / Q000378:metabolism / Q000532:radiotherapy; D019047:Phantoms, Imaging; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D011880:Radiotherapy Planning, Computer-Assisted / Q000706:statistics & numerical data*
chemical_list: D011838:Radiation-Sensitizing Agents; D006371:Helium; D008094:Lithium; D001895:Boron