title: Short-term outcomes following intrauterine transfusion in Scotland.
abstract: OBJECTIVE
  To describe neonatal outcomes following intrauterine transfusion (IUT) for severe Rhesus isoimmunisation from 1993 to 2004.
  
  
  RESULTS
  116 neonates who had undergone 457 IUTs (median 4, range 1-9) were identified. Three neonates died, all before 1995 (two because of hypoxic ischaemic multiorgan failure and one because of overwhelming Escherichia coli sepsis). 13 neonates (11%) were delivered by emergency Caesarean section following either IUT complication or spontaneous onset of preterm labour. They were more likely to require intubation (p<0.0001), on-going respiratory support (p=0.0007) and an exchange transfusion (p=0.007). 23 (20%) required an exchange transfusion and 63 (54%) at least one top-up transfusion.
  
  
  CONCLUSIONS
  Management of severe Rhesus disease is associated with encouraging neonatal outcomes and most infants can be managed with phototherapy and a few top-up transfusions. IUT complications are rare but significantly increase neonatal mortality and morbidity. Antenatal counselling should address the likely postnatal course for these infants.
authors.affiliation: Queen Mother's Hospital, Dalnair Street, Glasgow, Scotland, UK. lauramcglone@doctors.org.uk
authors.forename: Laura
authors.initials: L
authors.lastname: McGlone
authors.forename: J H
authors.initials: JH
authors.lastname: Simpson
authors.forename: C
authors.initials: C
authors.lastname: Scott-Lang
authors.forename: A D
authors.initials: AD
authors.lastname: Cameron
authors.forename: J
authors.initials: J
authors.lastname: Brennand
mesh_terms: D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects; D002585:Cesarean Section; D004630:Emergencies; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D018743:Perinatal Care / Q000379:methods; D010789:Phototherapy; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D012189:Retrospective Studies; D012203:Rh Isoimmunization / Q000628:therapy*; D016896:Treatment Outcome