title: Current concepts in stereotactic radiosurgery - a neurosurgical and radiooncological point of view.
abstract: Stereotactic radiosurgery is related to the history of "radiotherapy" and "stereotactic neurosurgery". The concepts for neurosurgeons and radiooncologists have been changed during the last decade and have also transformed neurosurgery. The gamma knife and the stereotactically modified linear accelerator (LINAC) are radiosurgical equipments to treat predetermined intracranial targets through the intact skull without damaging the surrounding normal brain tissue. These technical developments allow a more precise intracranial lesion control and offer even more conformal dose plans for irregularly shaped lesions. Histological determination by stereotactic biopsy remains the basis for any otherwise undefined intracranial lesion. As a minimal approach, it allows functional preservation, low risk and high sensitivity. Long-term results have been published for various indications. The impact of radiosurgery is presented for the management of gliomas, metastases, brain stem lesions, benign tumours and vascular malformations and selected functional disorders such as trigeminal neuralgia. In AVM's it can be performed as part of a multimodality strategy including resection or endovascular embolisation. Finally, the technological advances in radiation oncology as well as stereotactic neurosurgery have led to significant improvements in radiosurgical treatment opportunities. Novel indications are currently under investigation. The combination of both, the neurosurgical and the radiooncological expertise, will help to minimize the risk for the patient while achieving a greater treatment success.
authors.affiliation: Department of Neurosurgery, University of Düsseldorf, Germany. jan.vesper@med.uni-duesseldorf.de
authors.forename: Jan
authors.initials: J
authors.lastname: Vesper
authors.forename: B
authors.initials: B
authors.lastname: Bölke
authors.forename: C
authors.initials: C
authors.lastname: Wille
authors.forename: P A
authors.initials: PA
authors.lastname: Gerber
authors.forename: C
authors.initials: C
authors.lastname: Matuschek
authors.forename: M
authors.initials: M
authors.lastname: Peiper
authors.forename: H J
authors.initials: HJ
authors.lastname: Steiger
authors.forename: W
authors.initials: W
authors.lastname: Budach
authors.forename: G
authors.initials: G
authors.lastname: Lammering
mesh_terms: D001927:Brain Diseases / Q000601:surgery*; D001932:Brain Neoplasms / Q000556:secondary / Q000601:surgery; D001933:Brain Stem / Q000473:pathology / Q000601:surgery; D020785:Central Nervous System Vascular Malformations / Q000601:surgery; D006801:Humans; D009493:Neurosurgery; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D019292:Skull Base Neoplasms / Q000601:surgery