Coronary heart disease of females: lessons learned from nonhuman primates.
The cynomolgus monkey model has contributed to significant advances regarding the understanding of coronary artery atherosclerosis of females. There are currently 8 million women in the United States living with heart disease, necessitating further study and understanding of this leading cause of morbidity and mortality for postmenopausal women. Specifically, studies involving the monkey model have allowed greater understanding of the effect of the stage of reproductive life, time since menopause, and the extent of subclinical atherosclerosis as determinates of estrogen-mediated effects on arteries. Utilizing the commonalities among monkeys and human beings, these studies have shown that postmenopausal atherosclerosis is associated with the premenopausal reproductive timeframe. In addition, monkey studies have shown that estrogen deficiency during the premenopausal stage is extremely relevant regarding the progression of atherosclerosis. After several postmenopausal years, however, studies have shown that estrogen has no beneficial effects on atherosclerosis progression and may, in fact, be deleterious. Studies using the monkey model are currently underway to investigate further uses and possibilities of postmenopausal hormone therapy for treating menopausal symptoms while protecting the breast and uterus and inhibiting the progression of coronary artery atherosclerosis. These studies will hopefully clarify the role of estrogen and eliminate the need for the possibly harmful progestin effects through the use of a highly selective estrogen receptor modulator.
Clarkson
Thomas B
TB
Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1040, USA. tclarkso@wfubmc.edu
Mehaffey
Margaret H
MH
D000818:Animals; D003327:Coronary Disease / Q000209:etiology / Q000503:physiopathology*; D004195:Disease Models, Animal; D004967:Estrogens / Q000172:deficiency / Q000378:metabolism*; D005260:Female; D006801:Humans; D008252:Macaca fascicularis; D008593:Menopause / Q000502:physiology*; D013315:Stress, Psychological / Q000150:complications
D004967:Estrogens