Fundamentals of quantitative dynamic contrast-enhanced MR imaging.
Quantitative analysis of dynamic contrast-enhanced MR imaging (DCE-MR imaging) has the power to provide information regarding physiologic characteristics of the microvasculature and is, therefore, of great potential value to the practice of oncology. In particular, these techniques could have a significant impact on the development of novel anticancer therapies as a promising biomarker of drug activity. Standardization of DCE-MR imaging acquisition and analysis to provide more reproducible measures of tumor vessel physiology is of crucial importance to realize this potential. The purpose of this article is to review the pathophysiologic basis and technical aspects of DCE-MR imaging techniques.
Paldino
Michael J
MJ
Division of Neuroradiology, Department of Radiology, Duke University Medical Center, Box 3808, Erwin Road, Durham, NC 27710, USA. paldi001@mc.duke.edu
Barboriak
Daniel P
DP
D014408:Biomarkers, Tumor / Q000032:analysis; D003287:Contrast Media / Q000493:pharmacokinetics*; D003937:Diagnosis, Differential; D005682:Gadolinium / Q000493:pharmacokinetics*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008433:Mathematics; D009369:Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000473:pathology
D014408:Biomarkers, Tumor; D003287:Contrast Media; D005682:Gadolinium