Psychosis and autism: magnetic resonance imaging study of brain anatomy.
BACKGROUND
Autism-spectrum disorder is increasingly recognised, with recent studies estimating that 1% of children in South London are affected. However, the biology of comorbid mental health problems in people with autism-spectrum disorder is poorly understood.


OBJECTIVE
To investigate the brain anatomy of people with autism-spectrum disorder with and without psychosis.


METHODS
We used in vivo magnetic resonance imaging and compared 30 adults with autism-spectrum disorder (14 with a history psychosis) and 16 healthy controls.


RESULTS
Compared with controls both autism-spectrum disorder groups had significantly less grey matter bilaterally in the temporal lobes and the cerebellum. In contrast, they had increased grey matter in striatal regions. However, those with psychosis also had a significant reduction in grey matter content of frontal and occipital regions. Contrary to our expectation, within autism-spectrum disorder, comparisons revealed that psychosis was associated with a reduction in grey matter of the right insular cortex and bilaterally in the cerebellum extending into the fusiform gyrus and the lingual gyrus.


CONCLUSIONS
The presence of neurodevelopmental abnormalities normally associated with autism-spectrum disorder might represent an alternative 'entry-point' into a final common pathway of psychosis.
Toal
Fiona
F
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. fiona.toal@forensicare.vic.gov.au
Bloemen
Oswald J N
OJ
Deeley
Quinton
Q
Tunstall
Nigel
N
Daly
Eileen M
EM
Page
Lisa
L
Brammer
Michael J
MJ
Murphy
Kieran C
KC
Murphy
Declan G M
DG
D000328:Adult; D001321:Autistic Disorder / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000453:epidemiology / Q000473:pathology*; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology / Q000473:pathology; D055815:Young Adult