[IGF-1 receptors in the brain control longevity in mice].
Using a mouse model relevant for humans, lifespan can be prolonged by reducing IGF-I signaling selectively in the central nervous system. This effect occurred through changes in specific neuroendocrine pathways. Investigating the pathophysiological mechanism, we found that IGF receptors in the brain steered the development of the somatotropic axis, which in turn altered the individual growth trajectory and lifespan. Our work is experimental proof that chronically low IGF-I and low growth hormone (GH) levels favor long lifespan and postpone age-related mortality. Our results, together with other recent reports, challenge the notion that GH can slow down or prevent human aging. This is important because growth hormone is sometimes proposed to elderly people as a substitutive treatment in order to compensate the negative effects of aging.
Holzenberger
Martin
M
Centre de Recherche Inserm, Bâtiment Kourilsky, Hôpital Saint-Antoine, 75571 Paris Cedex 12, France. martin.holzenberger@inserm.fr
D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D013006:Growth Hormone / Q000502:physiology; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology; D006579:Heterozygote; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D007448:Invertebrates / Q000502:physiology; D008136:Longevity / Q000502:physiology*; D008322:Mammals / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology; D017526:Receptor, IGF Type 1 / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology
D009419:Nerve Tissue Proteins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D017526:Receptor, IGF Type 1