title: Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis.
abstract: BACKGROUND
  Stimulation of interleukin-22 receptor alpha-1 (IL22RA1) was reported to increase the innate immune responses in inflammatory diseases. Moreover, a reduced level of IL22RA1 was found in patients with recalcitrant CRS with nasal polyps.
  
  
  OBJECTIVE
  To explore association between single nucleotide polymorphisms (SNPs) in IL22RA1 and severe CRS.
  
  
  METHODS
  We extracted DNA from 206 cases with severe CRS and 196 postal code-matched controls. Twenty-three SNPs in the IL22RA1 gene were selected from the pooling-based genome-wide association study and from the CEU HapMap dataset and genotyped. PLINK software was used to determine association.
  
  
  RESULTS
  After Bonferroni correction, three SNPs (rs4292900 P(nom) = 0.0006, OR = 1.757; rs4648936 P(nom) = 0.0011, OR = 1.716; rs16829225 P(nom) = 0.0014, OR = 1.977) show significant differences in allelic frequencies between cases and controls.
  
  
  CONCLUSIONS
  Polymorphisms in IL22RA1 are associated with severe CRS. Replication and functional studies are involved to better understand the mechanism by which these polymorphisms contribute to the pathogenesis of CRS.
authors.affiliation: Department of Otolaryngology, Hôtel-Dieu Hospital, Montreal University, Montreal, PQ, Canada.
authors.forename: Leandra Mfuna
authors.initials: LM
authors.lastname: Endam
authors.forename: Yohan
authors.initials: Y
authors.lastname: Bossé
authors.forename: Abdelali
authors.initials: A
authors.lastname: Filali-Mouhim
authors.forename: Chantale
authors.initials: C
authors.lastname: Cormier
authors.forename: Pierre
authors.initials: P
authors.lastname: Boisvert
authors.forename: Louis-Philippe
authors.initials: LP
authors.lastname: Boulet
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hudson
authors.forename: Martin
authors.initials: M
authors.lastname: Desrosiers
mesh_terms: D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D049670:History, 17th Century; D006801:Humans; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D018123:Receptors, Interleukin / Q000235:genetics*; D012220:Rhinitis / Q000235:genetics*; D012852:Sinusitis / Q000235:genetics*; D011795:Surveys and Questionnaires
chemical_list: C433253:IL22RA2 protein, human; D018123:Receptors, Interleukin