title: Vulvar cancer and the need for awareness of precursor lesions.
abstract: Vulvar cancer continues to rise in incidence. In the absence of screening, attempts to reduce this cancer must focus on recognizing precursor lesions, namely, lichen sclerosus and vulvar intraepithelial neoplasia (VIN). The steep rise in human papillomavirus-repeated VIN will fall after the introduction of vaccination against human papillomavirus; in the meantime, those patients with VIN must be treated and then reviewed carefully and frequently. Lichen sclerosus has a 3% to 5% risk of progressing to vulvar cancer. Recommendations about which patients require referral to and follow-up by specialists/specialist clinics are given.
authors.affiliation: Department of Gynaecology, Royal Free Campus, Royal Free and University College Hospital, University College London, London, UK. a.maclean@medsch.ucl.ac.uk
authors.forename: Allan B
authors.initials: AB
authors.lastname: Maclean
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Jones
authors.forename: James
authors.initials: J
authors.lastname: Scurry
authors.forename: Sallie
authors.initials: S
authors.lastname: Neill
mesh_terms: D002277:Carcinoma / Q000473:pathology* / Q000628:therapy / Q000821:virology; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000473:pathology; D007724:Vulvar Lichen Sclerosus / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000628:therapy / Q000821:virology