title: Decreasing concentration of interstitial glucose in REM sleep in subjects with normal glucose tolerance.
abstract: OBJECTIVE
  Sleep is divided into two major stages, non-rapid eye movement (NREM) and rapid eye movement (REM), which are distinct in various neuroendocrine respects. NREM/REM cycles influence insulin and glucagon secretion; however, glucose concentrations in REM compared with NREM have not been directly explored. The aim was to investigate the differences in glucose concentrations in interstitial fluid (IGC) between NREM/REM cycles using a continuous glucose monitoring system (CGMS).
  
  
  METHODS
  Thirteen subjects were eligible for analysis out of the 28 enrolled. All underwent standard polysomnography for the assessment of sleep stages and the exclusion of sleep apnoea syndrome with CGMS and subsequent morning oral glucose tolerance test (exclusion of glucose intolerance or diabetes).
  
  
  RESULTS
  The IGC in REM fell in 12 out of the 13 subjects, whereas the IGC in NREM increased in eight out of the 13 subjects. Therefore, the mean change of IGC differed in direction between sleep stages: -0.028 (-0.045 to -0.011) for REM vs. 0.005 (-0.012 to 0.017) for NREM [median (QR), P = 0.007, n = 13], with the mean difference of 0.038 mmol/l x 5 min(-1) (95% confidence interval 0.012, 0.064). The mean glucose concentration in REM sleep was lower than in NREM: 4.29 +/- 1.00 vs. 4.53 +/- 0.90 mmol/l (mean +/- sd, P = 0.003, n = 13).
  
  
  CONCLUSIONS
  The decrease in IGC in REM compared with NREM sleep, with lower absolute values, may arise from different physiological events observed in these sleep stages. The REM-related decline in glucose concentrations may be a risk factor for nighttime hypoglycaemia.
authors.affiliation: Department of Clinical Physiology, Sleep and Respiratory Disorders Centre, Medical University of Lodz, Lodz, Poland. pbialasiewicz@neostrada.pl
authors.forename: P
authors.initials: P
authors.lastname: Bialasiewicz
authors.forename: M
authors.initials: M
authors.lastname: Pawlowski
authors.forename: D
authors.initials: D
authors.lastname: Nowak
authors.forename: J
authors.initials: J
authors.lastname: Loba
authors.forename: L
authors.initials: L
authors.lastname: Czupryniak
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006801:Humans; D007003:Hypoglycemia / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012890:Sleep / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology; D055815:Young Adult
chemical_list: D001786:Blood Glucose