Synthesis of spiroannulated oligopyrrole macrocycles derived from lithocholic acid.
Two new steroidal spiroannulated calix[4]pyrroles 5 and 10, derived from bile acids (lithocholate), were prepared by the acid catalyzed condensation of methyl-3,3-bis(pyrrol-2-yl)-5beta-cholan-24-oate 3 with carbonyl compounds and with 2,2'-propane-2,2-diylbis(1H-pyrrole), respectively. The new compounds were fully characterized by physicochemical methods.
Huong
Nguyen Thi Thu
NT
Department of Chemistry, J.E. Purkyne University, Ceské mládeze 8, 400 96 Ustí nad Labem, Czech Republic.
Klímková
Petra
P
Sorrenti
Alessandro
A
Mancini
Giovanna
G
Drasar
Pavel
P
D002942:Circular Dichroism; D008095:Lithocholic Acid / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D011758:Pyrroles / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D047028:Macrocyclic Compounds; D011758:Pyrroles; D013141:Spiro Compounds; D008095:Lithocholic Acid