Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration.
Aging-associated neurodegenerative diseases significantly influence the quality of life of affected individuals. Genetic approaches, combined with genomic technology, have provided powerful insights into common late-onset diseases, such as age-related macular degeneration (AMD). Here, we discuss current findings on the genetics of AMD to highlight areas of rapid progress and new challenges. We also attempt to integrate available genetic and biochemical data with cellular pathways involved in aging to formulate an integrated model of AMD pathogenesis.
Swaroop
Anand
A
Neurobiology-Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA. swaroopa@nei.nih.gov
Chew
Emily Y
EY
Rickman
Catherine Bowes
CB
Abecasis
Gonçalo R
GR
D017668:Age of Onset; D000818:Animals; D004195:Disease Models, Animal; D005123:Eye / Q000033:anatomy & histology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008019:Life Style; D008268:Macular Degeneration / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy