Effect of a peripheral nerve block on torque produced by repetitive electrical stimulation.
Neuromuscular electrical stimulation (NMES) generates contractions by activation of motor axons (peripheral mechanism), but the afferent volley also contributes by recruiting spinal motoneurons synaptically (central mechanism), which recruits motoneurons according to Henneman's size principle. Thus, we hypothesized that contractions that develop due to a combination of peripheral and central mechanisms will fatigue less rapidly than when electrically evoked contractions are generated by the activation of motor axons alone. Plantar-flexion torque evoked by NMES over the triceps surae was compared in five able-bodied subjects before (Intact) and during (Blocked) a complete anesthetic block of the tibial and common peroneal nerves. In the Blocked condition, plantar-flexion torque could only develop from the direct activation of motor axons beneath the stimulating electrodes. NMES was delivered using three protocols: protocol A, constant 100 Hz for 30 s; protocol B, four 2-s bursts of 100 Hz alternating with 20-Hz stimulation; and protocol C, alternating 100 Hz bursts (1 s on, 1 s off) for 30 s. The percent change in evoked plantar flexion torque from the beginning to the end of the stimulation differed (P < 0.05) between Intact and Blocked conditions for all protocols (Intact: protocol A = +125%, B = +230%, C = +78%; Blocked: protocol A = -79%, B = -15%, C = -35%). These results corroborate previous evidence that NMES can evoke contractions via the recruitment of spinal motoneurons in addition to the direct recruitment of motor axons. We now show that NMES delivered for periods of up to 30 s generates plantar-flexion torque which decreases when only motor axons are recruited and increases when the central nervous system can contribute.
Lagerquist
Olle
O
Human Neurophysiology Laboratory, Faculty of Physical Education and Recreation, Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada.
Walsh
Lee D
LD
Blouin
Jean-Sébastien
JS
Collins
David F
DF
Gandevia
Simon C
SC
D000328:Adult; D000772:Anesthesia, Local; D000779:Anesthetics, Local; D002045:Bupivacaine; D004338:Drug Combinations; D004558:Electric Stimulation / Q000379:methods*; D004576:Electromyography; D004837:Epinephrine; D006801:Humans; D008012:Lidocaine; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology*; D009407:Nerve Block; D010525:Peripheral Nerves / Q000187:drug effects / Q000502:physiology*; D011999:Recruitment, Neurophysiological / Q000187:drug effects / Q000502:physiology; D019415:Torque
D000779:Anesthetics, Local; D004338:Drug Combinations; D008012:Lidocaine; D002045:Bupivacaine; D004837:Epinephrine