title: ANNIE: integrated de novo protein sequence annotation.
abstract: Function prediction of proteins with computational sequence analysis requires the use of dozens of prediction tools with a bewildering range of input and output formats. Each of these tools focuses on a narrow aspect and researchers are having difficulty obtaining an integrated picture. ANNIE is the result of years of close interaction between computational biologists and computer scientists and automates an essential part of this sequence analytic process. It brings together over 20 function prediction algorithms that have proven sufficiently reliable and indispensable in daily sequence analytic work and are meant to give scientists a quick overview of possible functional assignments of sequence segments in the query proteins. The results are displayed in an integrated manner using an innovative AJAX-based sequence viewer. ANNIE is available online at: http://annie.bii.a-star.edu.sg. This website is free and open to all users and there is no login requirement.
authors.affiliation: Bioinformatics Institute, A*Star, Singapore.
authors.forename: Hong Sain
authors.initials: HS
authors.lastname: Ooi
authors.forename: Chia Yee
authors.initials: CY
authors.lastname: Kwo
authors.forename: Michael
authors.initials: M
authors.lastname: Wildpaner
authors.forename: Fernanda L
authors.initials: FL
authors.lastname: Sirota
authors.forename: Birgit
authors.initials: B
authors.lastname: Eisenhaber
authors.forename: Sebastian
authors.initials: S
authors.lastname: Maurer-Stroh
authors.forename: Wing Cheong
authors.initials: WC
authors.lastname: Wong
authors.forename: Alexander
authors.initials: A
authors.lastname: Schleiffer
authors.forename: Frank
authors.initials: F
authors.lastname: Eisenhaber
authors.forename: Georg
authors.initials: G
authors.lastname: Schneider
mesh_terms: D000465:Algorithms; D020539:Sequence Analysis, Protein; D012984:Software; D014584:User-Computer Interface