title: Multicell simulations of development and disease using the CompuCell3D simulation environment.
abstract: Mathematical modeling and computer simulation have become crucial to biological fields from genomics to ecology. However, multicell, tissue-level simulations of development and disease have lagged behind other areas because they are mathematically more complex and lack easy-to-use software tools that allow building and running in silico experiments without requiring in-depth knowledge of programming. This tutorial introduces Glazier-Graner-Hogeweg (GGH) multicell simulations and CompuCell3D, a simulation framework that allows users to build, test, and run GGH simulations.
authors.affiliation: Biocomplexity Institute and Department of Physics, Indiana University, Bloomington, USA.
authors.forename: Maciej H
authors.initials: MH
authors.lastname: Swat
authors.forename: Susan D
authors.initials: SD
authors.lastname: Hester
authors.forename: Ariel I
authors.initials: AI
authors.lastname: Balter
authors.forename: Randy W
authors.initials: RW
authors.lastname: Heiland
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Zaitlen
authors.forename: James A
authors.initials: JA
authors.lastname: Glazier
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D015509:Developmental Biology; D004194:Disease; D006801:Humans; D021621:Imaging, Three-Dimensional; D008433:Mathematics; D008962:Models, Theoretical; D011381:Programming Languages; D012984:Software