title: Glucose levels during oral glucose tolerance tests and gamma-glutamyl transpeptidase are predictors of change from normal to impaired glucose tolerance in healthy middle-aged Japanese men.
abstract: We evaluated the predictors of the development from normal to impaired glucose tolerance (IGT) in healthy middle-aged Japanese men. Forty male subjects who showed normal glucose tolerance (NGT) levels based on WHO criteria and who had undergone 75-g OGTT annually for 10 years were selected in the database of medical checkups retrospectively, and divided into two groups: those retaining NGT and those that developed IGT. Gamma-glutamyl transpeptidase (GGT) and the glucose levels at 30 and 60 min were significantly associated with the development of IGT in the Cox proportional hazard model. However, other clinical characteristics and the glucose levels at pre-load and at 120 min were not significantly associated with the development of IGT. GGT and the glucose levels at 30 and 60 min after the 75-g glucose load were predictors of development from NGT to IGT in healthy middle-aged Japanese men.
authors.affiliation: Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan. kentaro@nms.ac.jp
authors.forename: Kentaro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Kenzo
authors.initials: K
authors.lastname: Oba
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yuu
authors.initials: Y
authors.lastname: Okuyama
authors.forename: Motoshi
authors.initials: M
authors.lastname: Ouchi
authors.forename: Kazunari
authors.initials: K
authors.lastname: Suzuki
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Masao
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Igari
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
mesh_terms: D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data; D001786:Blood Glucose / Q000032:analysis*; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis*; D005951:Glucose Tolerance Test; D006262:Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D005723:gamma-Glutamyltransferase / Q000032:analysis / Q000097:blood*
chemical_list: D001786:Blood Glucose; D005723:gamma-Glutamyltransferase