Genetic alterations detected by comparative genomic hybridization and recurrence rate in epithelial ovarian carcinoma.
To assess the putative correlation between comparative genomic hybridization (CGH)-detectable genetic alterations in epithelial ovarian cancer and disease recurrence, conventional CGH was performed on 45 epithelial ovarian cancers: 26 tumors from sporadic, BRCA mutation noncarriers and 11 and 8 tumors from BRCA1 and BRCA2 mutation carriers, respectively. Relevant clinical data, including histology, grade, stage, size of residual tumor, recurrence, and survival, were obtained from outpatient and inpatient charts. Among the 45 cases, the most common regions involving gain of DNA copy number were 3q (n = 23; 51%), 8q (n = 21; 47%), and 1q (n = 14; 31%), and the most common regions with loss were 19 and 22 at 9 cases (20%) each, followed by 5q (n = 6; 13%). In multivariate analysis, the total number of genetic alterations was not associated with risk of recurrence, but gain in 5p was associated with a higher risk of recurrence (hazard ratio HR = 6.06, P = 0.0399), and gain in 1p as well as loss in 5q were associated with a significant decrease in recurrence (HR = 0.08, P = 0.0079, and HR = 0.10, P = 0.0143, respectively). Recurrence rate in patients with epithelial ovarian cancer is seemingly associated with specific genetic alterations detected by CGH, but the specific genes involved and the implications of these findings await further studies.
Bruchim
Ilan
I
Division of Gynecologic Oncology, McGill-SMBD Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada.
Israeli
Ofir
O
Mahmud
Salaheddin M
SM
Aviram-Goldring
Ayala
A
Rienstein
Shlomit
S
Friedman
Eitan
E
Ben-Baruch
Gilad
G
Gotlieb
Walter H
WH
D000368:Aged; D002277:Carcinoma / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D055028:Comparative Genomic Hybridization; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism