title: A comparative study of pathological staging systems in predicting recurrent hepatocellular carcinoma after liver transplantation.
abstract: OBJECTIVE
  The applicability of the staging systems of hepatocellular carcinoma (HCC) to liver transplantation (LT) has not been fully evaluated. Therefore, we compared the HCC recurrence after LT as predicted by various staging systems, including the American Joint Committee on Cancer (AJCC) system 5th edition, the AJCC system 6th edition, the American Liver Tumor Study Group (ALTSG) system, and the Liver Cancer Study Group of Japan (LCSGJ) system.
  
  
  METHODS
  A total of 108 patients who had HCC were classified according to these systems. We compared cumulative recurrence curves, recurrence-free survival curves, and overall survival curves of the systems estimated by Kaplan-Meier method. We compared cumulative event rates among different stages with the log-rank test for each staging system.
  
  
  RESULTS
  The log-rank test showed that the cumulative recurrence rates were different among different stages with a statistical significance for the staging systems except for the AJCC 5th edition system. Cumulative recurrence curves by the AJCC 6th edition system and the LCSGJ system showed better visual separation than the other two systems. With respect to recurrence-free survival and overall survival, no staging systems showed significant discriminative power.
  
  
  CONCLUSIONS
  The current AJCC tumor-node-metastasis staging and the LCSGJ system are superior in predicting HCC recurrence after LT.
authors.affiliation: Laboratory of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan. tokuno@legal.med.kyoto-u.ac.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Okuno
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Tsuruyama
authors.forename: Hironori
authors.initials: H
authors.lastname: Haga
authors.forename: Mikiko
authors.initials: M
authors.lastname: Ueda
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Takada
authors.forename: Yoji
authors.initials: Y
authors.lastname: Maetani
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Manabe
authors.forename: Keiji
authors.initials: K
authors.lastname: Tamaki
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D009367:Neoplasm Staging / Q000379:methods*; D055815:Young Adult