title: Expression and prognostic significance of SIRT1 in ovarian epithelial tumours.
abstract: OBJECTIVE
  Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, some studies have suggested that SIRT1 could be over-expressed in breast, prostate and colon cancers and up-regulated SIRT1 inactivates p53 by deacetylation. Therefore, we investigated the prevalence and the prognostic impact of SIRT1 and p53 expression in ovarian epithelial tumours.
  
  
  METHODS
  Immunohistochemical expression of SIRT1 and p53 were evaluated using tissue microarray in 40 cases of benign epithelial tumours, 36 cases of borderline tumours, and 90 cases of malignant tumours.
  
  
  RESULTS
  Expression of SIRT1 was significantly increased in malignant epithelial tumours compared to benign and borderline epithelial tumours (p < 0.001). In particular, a high proportion of serous carcinoma expressed SIRT1 (86%, 55/64 cases). Despite the frequent expression of SIRT1 in malignant ovarian epithelial tumours, serous carcinomas of high FIGO stage showed less frequent SIRT1 expression compared to that of low stage serous carcinomas (p = 0.029). Moreover, increased expression of SIRT1 in serous carcinoma correlated with increased overall survival by univariate (p = 0.014) and multivariate analyses.
  
  
  CONCLUSIONS
  Over-expression of SIRT1 may play an important role in the early stage of ovarian carcinogenesis.
authors.affiliation: Department of Pathology, Medical School and Institute for Medical Sciences, Chonbuk National University, Dukjin-Gu, Jeonju, Jeonbuk, Republic of Korea.
authors.forename: Kyu Yun
authors.initials: KY
authors.lastname: Jang
authors.forename: Kwan Sik
authors.initials: KS
authors.lastname: Kim
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Hwang
authors.forename: Keun Sang
authors.initials: KS
authors.lastname: Kwon
authors.forename: Kyung Ryoul
authors.initials: KR
authors.lastname: Kim
authors.forename: Ho Sung
authors.initials: HS
authors.lastname: Park
authors.forename: Byung-Hyun
authors.initials: BH
authors.lastname: Park
authors.forename: Myoung Ja
authors.initials: MJ
authors.lastname: Chung
authors.forename: Myoung Jae
authors.initials: MJ
authors.lastname: Kang
authors.forename: Dong Geun
authors.initials: DG
authors.lastname: Lee
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Moon
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D056564:Sirtuin 1; D037761:Sirtuins / Q000096:biosynthesis*; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins