title: Prevalence of significant peripheral artery disease in patients evaluated for percutaneous aortic valve insertion: Preprocedural assessment with multidetector computed tomography.
abstract: OBJECTIVE
  Percutaneous aortic valve insertion is an emerging treatment option for selected patients with severe aortic stenosis and may be done from a transfemoral or transapical approach. Concomitant atherosclerotic peripheral artery disease limits transfemoral access. We evaluated the potential role of multidetector computed tomography in preoperative assessment of vascular anatomy.
  
  
  METHODS
  Consecutive patients with severe aortic stenosis were included. Contrast-enhanced computed tomographic angiography of the thoracic and abdominal aorta and iliofemoral arteries was performed. Criteria of unfavorable iliofemoral anatomy were defined as a minimal luminal diameter of the common iliac, external iliac, or common femoral arteries of less than 8 mm, presence of greater than 60% circumferential calcification at the external-internal iliac bifurcation, and severe angulation between the common and external iliac arteries (< 90 degrees ). The prevalence of these criteria was evaluated and infrarenal aortic and iliofemoral arterial anatomy was compared in the groups with and without peripheral artery disease for any of these criteria.
  
  
  RESULTS
  One hundred patients (79 +/- 9 years, 59% male) were included. A total of 35 (35%) patients had at least one criterion of unsuitable iliofemoral anatomy, including 27 patients with small minimal luminal diameter (<8 mm), 12 patients with severe circumferential calcification at the iliac bifurcation (>60%), and 4 with severe angulation of the iliac arteries (<90 degrees ).
  
  
  CONCLUSIONS
  Significant atherosclerotic peripheral artery disease is common in the high-risk patient population currently evaluated for percutaneous aortic valve insertion. Computed tomography allows identification of patients with iliofemoral anatomy unfavorable for the transfemoral approach to percutaneous aortic valve insertion.
authors.affiliation: Heart & Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
authors.forename: Vikram
authors.initials: V
authors.lastname: Kurra
authors.forename: Paul
authors.initials: P
authors.lastname: Schoenhagen
authors.forename: Eric E
authors.initials: EE
authors.lastname: Roselli
authors.forename: Samir R
authors.initials: SR
authors.lastname: Kapadia
authors.forename: E Murat
authors.initials: EM
authors.lastname: Tuzcu
authors.forename: Roy
authors.initials: R
authors.lastname: Greenberg
authors.forename: Mateen
authors.initials: M
authors.lastname: Akhtar
authors.forename: Milind Y
authors.initials: MY
authors.lastname: Desai
authors.forename: Scott D
authors.initials: SD
authors.lastname: Flamm
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Halliburton
authors.forename: Lars G
authors.initials: LG
authors.lastname: Svensson
authors.forename: Srikanth
authors.initials: S
authors.lastname: Sola
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography / Q000379:methods; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D002406:Catheterization, Peripheral / Q000009:adverse effects / Q000379:methods*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D015995:Prevalence; D011336:Probability; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome