Asymmetric Synthesis of (+)-Iso-6-Cassine via Stereoselective Intramolecular Amidomercuration.
The first asymmetric synthesis of (+)-iso-6-cassine is described. Lipase-catalyzed resolution, enantioselective Overman rearrangement, and diastereoselective intramolecular amidomercuration were used for the installation of the three stereocenters in (+)-iso-6-cassine, and cross-metathesis was employed for the attachment of the side-chain.
Singh
Satwinder
S
Department of Chemisry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
Singh
Om V
OV
Han
Hyunsoo
H