Regulation of cellular proliferation, differentiation and cell death by activated Raf.
The protein kinases Raf-1, A-Raf and B-Raf connect receptor stimulation with intracellular signaling pathways and function as a central intermediate in many signaling pathways. Gain-of-function experiments shed light on the pleiotropic biological activities of these enzymes. Expression experiments involving constitutively active Raf revealed the essential functions of Raf in controlling proliferation, differentiation and cell death in a cell-type specific manner.
Thiel
Gerald
G
Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Homburg, Germany. gerald.thiel@uks.eu.
Ekici
Myriam
M
Rössler
Oliver G
OG