title: Infected hepatic and renal cysts: differential impact on outcome in autosomal dominant polycystic kidney disease.
abstract: BACKGROUND
  Infected cysts are a frequent and serious complication of autosomal dominant polycystic kidney disease. Such infections are classified into those affecting hepatic cysts and those affecting renal cysts. The purpose of this study was to compare the clinical course of infected hepatic cysts with that of infected renal cysts in patients with autosomal dominant polycystic kidney disease.
  
  
  METHODS
  We analyzed 43 patients referred to us for additional treatment of severely infected cysts between January 2004 and December 2006. All patients who required further treatment in addition to antibiotic therapy were included.
  
  
  RESULTS
  Aspiration was performed in all 28 patients with infected hepatic cysts. As a result, 17 patients were cured, 4 remain under treatment, and 6 died. One patient was cured by partial hepatectomy. Among the 15 patients with renal cysts, aspiration was performed in 4 with identifiable infected cysts, while renal transcatheter arterial embolization after appropriate antibiotic therapy was performed in 11 without identifiable infected cysts. No patient developed recurrence.
  
  
  CONCLUSIONS
  In patients with infected renal cysts, aspiration or renal transcatheter arterial embolization after appropriate antibiotic therapy was effective. Although aspiration was often effective in patients with infected hepatic cysts, a good outcome was less likely than in those with renal cysts.
authors.affiliation: Nephrology Center, Toranomon Hospital, Tokyo, Japan. suwabe@toranomon.gr.jp
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suwabe
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ubara
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Higa
authors.forename: Shohei
authors.initials: S
authors.lastname: Nakanishi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Sogawa
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Nomura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nishimura
authors.forename: Jyunichi
authors.initials: J
authors.lastname: Hoshino
authors.forename: Naoki
authors.initials: N
authors.lastname: Sawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Katori
authors.forename: Fumi
authors.initials: F
authors.lastname: Takemoto
authors.forename: Michio
authors.initials: M
authors.lastname: Nakamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Tomikawa
authors.forename: Shigeko
authors.initials: S
authors.lastname: Hara
authors.forename: Kenmei
authors.initials: K
authors.lastname: Takaichi
mesh_terms: D000328:Adult; D000368:Aged; D003560:Cysts / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome