title: Dimeric 1,4-benzoquinone derivatives and a resorcinol derivative from Ardisia gigantifolia.
abstract: Naturally occurring dimeric 1,4-benzoquinone derivatives, belamcandaquinones F, G, H, and I, as well as one resorcinol derivative and four known compounds, were isolated from rhizomes of Ardisia gigantifolia. Their structures were established by means of spectroscopic analyses. All compounds were tested against cell lines PC-3, EMT6, A549, Hela, RM-1, and SGC7901 for cytotoxicity in vitro. In comparison with cisplatin, compounds 5 and 6 showed a strong cytotoxicity with IC(50) values less than 30 microM for most cell lines tested.
authors.affiliation: Key Lab of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, PR China. liuhongwei60@yahoo.com.cn
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Ruiyun
authors.initials: R
authors.lastname: Yang
authors.forename: Manyuan
authors.initials: M
authors.lastname: Wang
authors.forename: Meiqing
authors.initials: M
authors.lastname: Zheng
authors.forename: Yisong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.forename: Hengshan
authors.initials: H
authors.lastname: Wang
mesh_terms: D031644:Ardisia / Q000737:chemistry*; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification*; D002460:Cell Line; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D016227:Benzoquinones; D012118:Resorcinols; C004532:quinone; C031389:resorcinol