title: Asymmetric total synthesis and revision of the absolute configuration of 4-keto-clonostachydiol.
abstract: The first total synthesis of the 14-membered natural macrocyclic bislactone 4-keto-clonostachydiol, along with its enantiomer, has been accomplished in 13 steps with overall yields of 8.4% and 8.0%, respectively. The absolute configuration of 4-keto-clonostachydiol 1 has been revised as (5S,10S,13S).
authors.affiliation: Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Han
authors.forename: Yingpeng
authors.initials: Y
authors.lastname: Su
authors.forename: Tuo
authors.initials: T
authors.lastname: Jiang
authors.forename: Yanfen
authors.initials: Y
authors.lastname: Xu
authors.forename: Xing
authors.initials: X
authors.lastname: Huo
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
authors.forename: Xinfu
authors.initials: X
authors.lastname: Pan
mesh_terms: D004852:Epoxy Compounds / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: C510703:4-keto-clonostachydiol; D004852:Epoxy Compounds; D007783:Lactones; C009068:propylene oxide