title: Influence of BMI on health-related quality of life: comparison between an obese adult cohort and age-matched population norms.
abstract: The aim of this study was to determine health-related quality of life and fatigue measures in obese subjects and to compare scores with age- and gender-matched population norms. A total of 163 obese subjects were recruited from laparoscopic-adjustable gastric banding or exercise and diet weight loss programs between March 2006 and December 2007. All subjects completed the Medical Outcomes Study Short Form 36 (SF-36), Assessment of Quality of Life (AQoL), and Multidimensional Assessment of Fatigue (MAF) questionnaires. One-sample t-tests were used to compare transformed scores with age- and gender-matched population norms and controls. Obese subjects have significantly lower SF-36 physical and emotional component scores, significantly lower AQoL utility scores and significantly higher fatigue scores compared to age-matched population norms. Within the study cohort, the SF-36 physical functioning, role physical and bodily pain scores, and AQoL utility index were even lower in subjects with clinical knee osteoarthritis (OA). However, obese individuals without OA still had significantly lower scores compared to population norms. Obesity is associated with impaired health-related quality of life and disability as measured by the SF-36, AQoL, and fatigue score (MAF) compared to matched population norms.
authors.affiliation: Institute of Bone and Joint Research, Kolling Institute, Department of Rheumatology, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Ananthila
authors.initials: A
authors.lastname: Anandacoomarasamy
authors.forename: Ian D
authors.initials: ID
authors.lastname: Caterson
authors.forename: Steven
authors.initials: S
authors.lastname: Leibman
authors.forename: Garett S
authors.initials: GS
authors.lastname: Smith
authors.forename: Phillip N
authors.initials: PN
authors.lastname: Sambrook
authors.forename: Marlene
authors.initials: M
authors.lastname: Fransen
authors.forename: Lyn M
authors.initials: LM
authors.lastname: March
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D015992:Body Mass Index; D004185:Disability Evaluation; D005221:Fatigue / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D020370:Osteoarthritis, Knee / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D010147:Pain Measurement; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires