Association between cholesterols, homocysteine and silent brain infarcts.
BACKGROUND
The aim of this study was to assess the relationship between total plasma homocysteine, cholesterol levels, vitamin B(12), folate, thyroid hormones, urea, ferritin, uric acid, C-reactive protein, cardiovascular risk factors and silent brain infarct (SBI) in patients without any neurological disorder. Whether the factors of interest were associated with SBI is investigated.


METHODS
One hundred and forty-two subjects with a mean age of 52.1 +/- 13.1 years (21-87 years) without any history of stroke, transient ischaemic attack and neurological abnormality were enrolled in this cross-sectional study. The subjects underwent brain magnetic resonance imaging and blood chemistry determinations. Student's t-test was used to compare differences in means of laboratory results between the groups with and without SBI. The chi(2)-test was used for categorized variables. Multiple logistic regression analysis was used to determine the independent predictors of SBI.


RESULTS
The group comprised 56 men and 86 women. SBI were found in 40 patients (28%). The low-density lipoprotein levels were significantly higher in the infarct group (P = 0.019), homocysteine concentrations were significantly higher in the men-infarct group (P = 0,029) and total cholesterol levels were significantly higher in the women-infarct group than the women non-infarct group (P = 0.006).


CONCLUSIONS
Serum low-density lipoprotein, total cholesterol and homocysteine levels were associated with SBI.
Oncel
C
C
Department of Neurology, Pamukkale University, Denizi, Turkey. cagatay_oncel@yahoo.com
Demir
S
S
Güler
S
S
Cenikli
U
U
Tabak
E
E
Kiroğlu
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001774:Blood Chemical Analysis; D020520:Brain Infarction / Q000097:blood* / Q000453:epidemiology*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D014805:Vitamin B 12 / Q000097:blood; D055815:Young Adult
D008077:Lipoproteins, LDL; D006710:Homocysteine; D005492:Folic Acid; D002784:Cholesterol; D014805:Vitamin B 12