title: Enantioselective synthesis of (R)-tolterodine via CuH-catalyzed asymmetric conjugate reduction.
abstract: An efficient and highly enantioselective method for the preparation of (R)-tolterodine is described. The synthesis was performed by CuH-catalyzed asymmetric conjugate reduction of a beta,beta-diaryl-substituted unsaturated nitrile as a key step, which is prepared by a stereoselective hydroarylation of alkynenitrile with aryl boronic acid. The synthesis was accomplished without employing the protection-deprotection sequence.
authors.affiliation: Department of Chemistry and Institute of Basic Science, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Kihyun
authors.initials: K
authors.lastname: Yoo
authors.forename: Hyohyun
authors.initials: H
authors.lastname: Kim
authors.forename: Jaesook
authors.initials: J
authors.lastname: Yun
mesh_terms: D001559:Benzhydryl Compounds / Q000138:chemical synthesis*; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D003408:Cresols / Q000138:chemical synthesis*; D006865:Hydrogenation; D018727:Muscarinic Antagonists; D009570:Nitriles / Q000737:chemistry; D010665:Phenylpropanolamine / Q000138:chemical synthesis*; D013237:Stereoisomerism; D000068737:Tolterodine Tartrate
chemical_list: D001559:Benzhydryl Compounds; D001897:Boronic Acids; D003408:Cresols; D018727:Muscarinic Antagonists; D009570:Nitriles; D010665:Phenylpropanolamine; D000068737:Tolterodine Tartrate