title: Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia.
abstract: OBJECTIVE
  The objective was to determine the value of ischemia-modified albumin (IMA) in the diagnosis of mesenteric embolism. The authors investigated whether or not plasma IMA levels rose in the acute period in a rat model of mesenteric ischemia and the related time-dependent changes.
  
  
  METHODS
  In this randomized, controlled, nonblinded trial, 36 mature female Wistar rats were divided into six groups: three control (Groups I, III, and V) and three ischemia (Groups II, IV, and VI). In the control groups, blood was sampled at 30 minutes (Group I), 2 hours (Group III), and 6 hours (Group V) following a simple laparotomy. In the ischemia groups, following laparotomy, the superior mesenteric artery (SMA) was clamped using a bulldog clamp, and blood samples were taken at 30 minutes (Group II), 2 hours (Group IV), and 6 hours (Group VI).
  
  
  RESULTS
  Plasma IMA levels in the ischemia groups were significantly higher compared to those of the control groups (p < 0.004). In addition, levels were higher in the 6-hour blood samples of the ischemia group than in the 2-hour and 30-minute samples (p < 0.001). Serum IMA was also higher in the 2-hour blood samples of the ischemia group than in the 30-minute samples (p < 0.001).
  
  
  CONCLUSIONS
  These preliminary findings suggest that serum IMA levels may represent a significant parameter in the early diagnosis of acute mesenteric ischemia and that further studies are necessary.
authors.affiliation: Department of Emergency Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Gunduz
authors.forename: Suha
authors.initials: S
authors.lastname: Turkmen
authors.forename: Suleyman
authors.initials: S
authors.lastname: Turedi
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
authors.forename: Esin
authors.initials: E
authors.lastname: Yulug
authors.forename: Hülya
authors.initials: H
authors.lastname: Ulusoy
authors.forename: Suleyman Caner
authors.initials: SC
authors.lastname: Karahan
authors.forename: Murat
authors.initials: M
authors.lastname: Topbas
mesh_terms: D000818:Animals; D003250:Constriction; D004195:Disease Models, Animal; D005260:Female; D007421:Intestine, Small / Q000473:pathology; D007511:Ischemia / Q000097:blood / Q000175:diagnosis*; D019344:Lactic Acid / Q000032:analysis; D008315:Malondialdehyde / Q000032:analysis; D017538:Mesenteric Artery, Superior; D008643:Mesentery / Q000098:blood supply*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D012709:Serum Albumin; D019344:Lactic Acid; D008315:Malondialdehyde