Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats.
Recent studies have revealed a close relationship between the pathophysiology of metabolic syndrome, which is characterized by obesity and hyperglycemia, and the functioning of internal molecular clocks. In this study, we show that the rhythmic mRNA expression of clock genes (Clock, Bmal1, Cry1, and Dbp) is not attenuated in the liver and visceral adipose tissues of Goto-Kakizaki rats, a model of nonobese, type 2 diabetes, as compared to control Wistar rats. Our results suggest that molecular clock impairment in peripheral tissues of obese diabetic animals may be either caused by obesity-related factor(s), but not hyperglycemia, or be a cause, but not a consequence, of hyperglycemia.
Ando
Hitoshi
H
Division of Clinical Pharmacology, Department of Pharmacology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan.
Ushijima
Kentarou
K
Yanagihara
Hayato
H
Hayashi
Yohei
Y
Takamura
Toshinari
T
Kaneko
Shuichi
S
Fujimura
Akio
A
D056930:ARNTL Transcription Factors; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D056926:CLOCK Proteins; D002940:Circadian Rhythm; D056931:Cryptochromes; D004268:DNA-Binding Proteins; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D005420:Flavoproteins / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors
D056930:ARNTL Transcription Factors; D051792:Basic Helix-Loop-Helix Proteins; D001786:Blood Glucose; D056926:CLOCK Proteins; D056931:Cryptochromes; D004268:DNA-Binding Proteins; D005420:Flavoproteins; D007328:Insulin; D012333:RNA, Messenger; D015534:Trans-Activators; D014157:Transcription Factors; C538965:Cry1 protein, rat; C485975:DBP protein, rat; C538945:Clock protein, rat