Post-translational modifications of ATP synthase in the heart: biology and function.
The ATP synthase complex is a critical enzyme in the energetic pathways of cells because it is the enzyme complex that produces the majority of cellular ATP. It has been shown to be involved in several cardiac phenotypes including heart failure and preconditioning, a cellular protective mechanism. Understanding the regulation of this enzyme is important in understanding the mechanisms behind these important phenomena. Recently there have been several post-translational modifications (PTM) reported for various subunits of this enzyme complex, opening up the possibility of differential regulation by these PTMs. Here we discuss the known PTMs in the heart and other mammalian tissues and their implication to function and regulation of the ATP synthase.
Kane
Lesley A
LA
Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD, USA.
Van Eyk
Jennifer E
JE
D000818:Animals; D020134:Catalytic Domain; D006333:Heart Failure / Q000201:enzymology*; D006801:Humans; D008929:Mitochondria, Heart / Q000201:enzymology*; D025261:Mitochondrial Proton-Translocating ATPases / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D011499:Protein Processing, Post-Translational
D025261:Mitochondrial Proton-Translocating ATPases