Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis.
The stromal vascular fraction (SVF) of adipose tissue is known to contain mesenchymal stem cells (MSC), T regulatory cells, endothelial precursor cells, preadipocytes, as well as anti-inflammatory M2 macrophages. Safety of autologous adipose tissue implantation is supported by extensive use of this procedure in cosmetic surgery, as well as by ongoing studies using in vitro expanded adipose derived MSC. Equine and canine studies demonstrating anti-inflammatory and regenerative effects of non-expanded SVF cells have yielded promising results. Although non-expanded SVF cells have been used successfully in accelerating healing of Crohn's fistulas, to our knowledge clinical use of these cells for systemic immune modulation has not been reported. In this communication we discuss the rationale for use of autologous SVF in treatment of multiple sclerosis and describe our experiences with three patients. Based on this rationale and initial experiences, we propose controlled trials of autologous SVF in various inflammatory conditions.
Riordan
Neil H
NH
Medistem Inc, San Diego, CA, USA. riordan@medisteminc.com
Ichim
Thomas E
TE
Min
Wei-Ping
WP
Wang
Hao
H
Solano
Fabio
F
Lara
Fabian
F
Alfaro
Miguel
M
Rodriguez
Jorge Paz
JP
Harman
Robert J
RJ
Patel
Amit N
AN
Murphy
Michael P
MP
Lee
Roland R
RR
Minev
Boris
B
D000273:Adipose Tissue / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D000818:Animals; D016026:Bone Marrow Transplantation; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D004285:Dogs; D006736:Horses; D006801:Humans; D008213:Lymphocyte Activation; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D023421:Models, Animal; D009103:Multiple Sclerosis / Q000601:surgery / Q000628:therapy*; D017154:Stromal Cells / Q000637:transplantation*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology / Q000502:physiology