Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage.
Cilostazol, an antiplatelet drug used to treat intermittent claudication, has been reported to offer neuroprotection and endothelial protection in animals with ischemic brain injury. Here, we evaluated the protection afforded by cilostazol against ischemic brain injury and hemorrhagic transformation. Mice subjected to a 2-h filamental middle cerebral artery (MCA) occlusion were treated with cilostazol (10mg/kg, intraperitoneally just after the occlusion) or with vehicle. Histological outcomes (infarct volume and hemorrhagic transformation) and Evans blue extravasation were assessed after reperfusion. Mean infarct volume, hemorrhagic transformation, and Evans blue extravasation were all significantly reduced in the cilostazol-treated group. Thus, cilostazol protected against ischemic brain injury and hemorrhagic transformation in mice subjected to transient focal cerebral ischemia.
Nonaka
Yuko
Y
Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan.
Tsuruma
Kazuhiro
K
Shimazawa
Masamitsu
M
Yoshimura
Shinichi
S
Iwama
Toru
T
Hara
Hideaki
H
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications* / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000209:etiology* / Q000517:prevention & control; D002544:Cerebral Infarction / Q000150:complications* / Q000503:physiopathology; D000077407:Cilostazol; D004195:Disease Models, Animal; D005070:Evans Blue; D007202:Indicators and Reagents; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000503:physiopathology; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D013777:Tetrazoles / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
D007202:Indicators and Reagents; D018696:Neuroprotective Agents; D013777:Tetrazoles; D005070:Evans Blue; D000077407:Cilostazol