title: Myelin peptides in multiple sclerosis.
abstract: The development of specific therapies for organ-specific autoimmune diseases requires the identification of relevant immunogenic epitopes, recognized by both pathogenic T cells and autoantibodies. Here, we review the most relevant studies focused in the identification of peptides in multiple sclerosis (MS) and the distinct T cell reactivity induced in patients compared to controls. Only a few studies reported significant differences in terms of T cell reactivity to them. The current knowledge on this issue, and the diagnostic and therapeutic possibilities opened by the identification of pathogenic MS epitopes are discussed in this paper.
authors.affiliation: Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Grau-López
authors.forename: D
authors.initials: D
authors.lastname: Raïch
authors.forename: C
authors.initials: C
authors.lastname: Ramo-Tello
authors.forename: M
authors.initials: M
authors.lastname: Naranjo-Gómez
authors.forename: A
authors.initials: A
authors.lastname: Dàvalos
authors.forename: R
authors.initials: R
authors.lastname: Pujol-Borrell
authors.forename: F E
authors.initials: FE
authors.lastname: Borràs
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Cáceres
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy*; D009186:Myelin Sheath / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D009418:S100 Proteins / Q000276:immunology; D014153:Transaldolase / Q000276:immunology; D038203:alpha-Crystallin B Chain / Q000276:immunology
chemical_list: D000941:Antigens; D018992:Myelin-Associated Glycoprotein; D010455:Peptides; D009418:S100 Proteins; D038203:alpha-Crystallin B Chain; D014153:Transaldolase