title: Pulp revascularization of immature teeth with apical periodontitis: a clinical study.
abstract: BACKGROUND
  The purpose of this study was to examine the effect of a pulpal revascularization procedure for immature necrotic teeth with apical periodontitis.
  
  
  METHODS
  Twelve patients, each with an immature permanent tooth with chronic or acute apical periodontitis, were recruited. A triantibiotic mix (ciprofloxacin, metronidazole, and minocycline) was used to disinfect the pulp for 1 week. Then a blood clot was created in the canal, over which grey mineral trioxide aggregate was placed. Patients were recalled periodically.
  
  
  RESULTS
  Six patients dropped from the study (as a result of pain or failure to induce bleeding after canal disinfection) and instead received a standard apexification procedure. Another 3 patients did not attend any recall appointments. The remaining teeth (n = 3) were found to exhibit complete root development, with a positive response to pulp testing.
  
  
  CONCLUSIONS
  Revascularization could be effective for managing immature permanent teeth with apical periodontitis with appropriate case selection.
authors.affiliation: Special Department, Peking University School and Hospital of Stomatology, Beijing, China.
authors.forename: Rui Yu
authors.initials: RY
authors.lastname: Ding
authors.forename: Gary Shun-pan
authors.initials: GS
authors.lastname: Cheung
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Xing Zhe
authors.initials: XZ
authors.lastname: Yin
authors.forename: Qian Qian
authors.initials: QQ
authors.lastname: Wang
authors.forename: Cheng Fei
authors.initials: CF
authors.lastname: Zhang
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000890:Anti-Infective Agents / Q000008:administration & dosage; D001641:Bicuspid / Q000473:pathology; D001777:Blood Coagulation / Q000502:physiology; D017610:Calcium Compounds / Q000627:therapeutic use; D002648:Child; D002939:Ciprofloxacin / Q000008:administration & dosage; D003782:Dental Pulp / Q000098:blood supply* / Q000503:physiopathology; D003786:Dental Pulp Cavity / Q000098:blood supply; D003790:Dental Pulp Necrosis / Q000628:therapy*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D007180:Incisor / Q000473:pathology; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008911:Minocycline / Q000008:administration & dosage; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009805:Odontogenesis / Q000502:physiology; D010087:Oxides / Q000627:therapeutic use; D010485:Periapical Periodontitis / Q000628:therapy*; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D018915:Root Canal Preparation / Q000379:methods; D012390:Root Canal Therapy / Q000379:methods*; D017640:Silicates / Q000627:therapeutic use; D019227:Tooth Apex / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D017607:Aluminum Compounds; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; D008795:Metronidazole; D002939:Ciprofloxacin; D008911:Minocycline