title: Abdominal visceral adiposity in the first trimester predicts glucose intolerance in later pregnancy.
abstract: OBJECTIVE
  To assess whether abdominal adiposity in early pregnancy is associated with a higher risk of glucose intolerance at a later gestational stage.
  
  
  METHODS
  Subcutaneous and visceral fat was measured with ultrasonography at approximately 12 weeks' gestation. A 50-g glucose challenge test (GCT) was performed between 24 and 28 weeks' gestation. The risk of having a positive GCT (>or=7.8 mmol/l) was determined in association with subcutaneous and visceral adipose tissue depths above their respective upper-quartile values relative to their bottom three quartile values.
  
  
  RESULTS
  Sixty-two women underwent GCTs. A visceral adipose tissue depth above the upper quartile value was significantly associated with a positive GCT in later pregnancy (adjusted odds ratio 16.9 [95% CI 1.5-194.6]). No associations were seen for subcutaneous adipose tissue.
  
  
  CONCLUSIONS
  Measurement of visceral adipose tissue depth in early pregnancy may be associated with glucose intolerance later in pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Aisling Mary
authors.initials: AM
authors.lastname: Martin
authors.forename: Howard
authors.initials: H
authors.lastname: Berger
authors.forename: Rosane
authors.initials: R
authors.lastname: Nisenbaum
authors.forename: Andrea Y
authors.initials: AY
authors.lastname: Lausman
authors.forename: Sharon
authors.initials: S
authors.lastname: MacGarvie
authors.forename: Carrie
authors.initials: C
authors.lastname: Crerar
authors.forename: Joel G
authors.initials: JG
authors.lastname: Ray
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology*; D006801:Humans; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D018570:Risk Assessment; D016216:Ultrasonography, Prenatal; D014781:Viscera / Q000033:anatomy & histology*