Neonatal acute myeloid leukemia in an infant whose mother was exposed to diethylstilboestrol in utero.
We report on an acute myeloid leukemia in a neonate whose mother was exposed to diethylstilboestrol in utero. The newborn presented with leukemia cutis, hemorrhagic skin lesions, hyperleucocytosis and disseminated intravascular coagulation. A bone marrow examination confirmed the diagnosis of acute monocytic leukemia with a t(11;19) MLL-ELL fusion transcript. Chemotherapy was initiated but the child developed a bilateral pulmonary infection that led to fatal respiratory distress. This case shows acute myeloid leukemia and the third pediatric leukemia reported after maternal diethylstilboestrol exposure.
Chantrain
C F
CF
Department of Pediatric Hematology-Oncology, St-Luc University Hospital, Université catholique de Louvain, Brussels, Belgium. christophe.chantrain@uclouvain.be
Sauvage
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D
Brichard
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B
Dupont
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S
Poirel
H A
HA
Ameye
G
G
De Weer
A
A
Vandenberghe
P
P
Detaille
T
T
Anslot
C
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de Cléty
S Clément
SC
Vermylen
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C
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D007247:Infertility, Female / Q000139:chemically induced; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000188:drug therapy / Q000235:genetics; D008297:Male; D009035:Mothers; D051788:Myeloid-Lymphoid Leukemia Protein; D015514:Oncogene Proteins, Fusion; D010375:Pedigree; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D004968:Estrogens, Non-Steroidal; C472772:MLL-ELL fusion protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein; D004054:Diethylstilbestrol