Adrenaline-induced chronic ocular hypertension in adult rabbits.
BACKGROUND
The aim of this study was to develop a new animal model to enhance our understanding of the biological pathomechanisms involved in glaucoma.


METHODS
Forty white giant rabbits were divided into a treated (N = 30) and a control group (N = 10). Boli of adrenaline hydrochloride (0.1 mL 0.1% solution) were repeatedly injected into the veins of the ears of the rabbits and physiological saline in the control group, respectively, for three months. Intraocular pressure (IOP) and outflow facility of the aqueous humour were measured prior to, during and after treatment (4-6 months, 7-9 months, 10-12 months).


RESULTS
In comparison to the control group, the adrenaline-treated group showed a significant increase in IOP both during treatment (25%) and 12 months after treatment (57%). Comparative analysis further showed that the aqueous humour outflow facility of the treated group increased by 16.5% during the treatment, and showed a continuous decrease of 60 % after treatment.


CONCLUSIONS
This rabbit model could be useful for further investigations of the pathomechanisms involved in glaucoma.
Mikheytseva
I
I
The Filatov Research Institute of Eye Diseases, Odessa, Ukraine.
Lipovetskaya
E
E
Kopp
O
O
Mozaffarieh
M
M
Grieshaber
M C
MC
Flammer
J
J
Meyer
P
P
D000818:Animals; D001993:Bronchodilator Agents; D002908:Chronic Disease; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine; D006801:Humans; D007429:Intraocular Pressure; D009798:Ocular Hypertension / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology*; D011817:Rabbits
D001993:Bronchodilator Agents; D004837:Epinephrine