title: Malnutrition-inflammation complex syndrome and hepatitis C in maintenance hemodialysis patients.
abstract: Protein-energy malnutrition and inflammation are among the leading causes of poor outcome in hemodialysis patients. Hepatitis C virus (HCV) infection is accompanied by elevated proinflammatory mediators, also found in dialysis patients with malnutrition-inflammation complex syndrome. We aimed to study the rate and characteristics of malnutrition-inflammation complex syndrome (MICS) in hemodialysis patients, especially those with hepatitis C. The study included 147 patients (mean age 55.1 +/- 12.9 years), 24.5% of whom were HCV-positive, undergoing adequate hemodialysis three times a week for the last 52.7 +/- 52.5 months. Parameters of nutrition and inflammation were investigated to evaluate MICS. HCV-positive vs. HCV-negative patients had significantly higher hematocrit (29.6 +/- 4.5 g/dL vs. 28.1 +/- 4.3, P < 0.05), uric acid (345.8 +/- 96.5 vs. 321.3 +/- 118.8 micromol/mL, P < 0.05), aspartate aminotransferase (AST, also known as serum glutamic oxaloacetic transaminase [SGOT]) (23.3 +/- 14.9 vs. 17.8 +/- 9 U/L, P < 0.008), alanine aminotransferase (ALT, also known as serum glutamic pyruvic transaminase [SGPT]) (41.2 +/- 28.7 vs. 26.6 +/- 17.1 U/L, P < 0.0003), serum creatinine (980.4 +/- 219.1 vs. 888.4 +/- 202.9 micromol/mL, P < 0.022), intact parathyroid hormone (329.7 +/- 630.5 vs. 110.2 +/- 145.3 pg/mL, P < 0.002), malnutrition-inflammation score (7.4 +/- 5.2 vs. 5.6 +/- 4.1, P < 0.038), and Charlson comorbidity index (4.5 +/- 1.5 vs. 4 +/- 1.4, P < 0.05). MICS had a prevalence of 20-40% in our study. HCV-positive patients had a significantly higher prevalence of MICS than HCV-negative patients (30-40% vs. 20-30%).
authors.affiliation: International Dialysis Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina. drw@teol.net
authors.forename: Vlastimir
authors.initials: V
authors.lastname: Vlatkovic
authors.forename: Jasna
authors.initials: J
authors.lastname: Trbojevic-Stankovic
authors.forename: Biljana
authors.initials: B
authors.lastname: Stojimirovic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D006400:Hematocrit; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000378:metabolism; D015995:Prevalence; D011502:Protein-Energy Malnutrition / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D006435:Renal Dialysis; D013577:Syndrome; D014527:Uric Acid / Q000378:metabolism; D055815:Young Adult
chemical_list: D010281:Parathyroid Hormone; D014527:Uric Acid; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase