Negative influence of paternal age on clinical intracytoplasmic sperm injection cycle outcomes in oligozoospermic patients.
OBJECTIVE
To evaluate the effect of male age on clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles, according to sperm concentration.


METHODS
Retrospective, observational study.


METHODS
Assisted reproduction center.


METHODS
The study included 1,024 couples undergoing ICSI cycles with fresh spermatozoa.


METHODS
The influence of paternal age on ICSI outcomes of oligozoospermic and normozoospermic patients was evaluated.


METHODS
Rates of high-quality embryos, pregnancy, implantation, and miscarriage were evaluated through linear logistic regression analyses.


RESULTS
When the sperm concentration was abnormal, paternal age influenced implantation (regression coefficient value = -0.7009) and pregnancy rates (odds ratio = 0.95, 95% confidence interval 0.91-0.99). However, in normozoospermic patients, no influence of paternal age was observed on implantation (regression coefficient value = 0.0566) or pregnancy rates (odds ratio = 1.00, 95% confidence interval 0.97-1.03).


CONCLUSIONS
For couples in which the men are oligozoospermic, the implantation rate could be impaired by increased paternal age. In these couples, the chance of pregnancy decreased 5% for each year of paternal age. When men are normozoospermic, this effect is not observed.
Ferreira
Renata Cristina
RC
Sapientiae Institute, Educational and Research Center in Assisted Reproduction, São Paulo, Brazil.
Braga
Daniela Paes de Almeida Ferreira
DP
Bonetti
Tatiana Carvalho de Souza
TC
Pasqualotto
Fabio Firmbach
FF
Iaconelli
Assumpto
A
Borges
Edson
E
D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology; D000328:Adult; D001755:Blastocyst / Q000166:cytology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000175:diagnosis / Q000628:therapy*; D010331:Paternal Age; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D011786:Quality Control; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data; D016896:Treatment Outcome