The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men.
The Toll-like receptor 4 (TLR4) has a wide spectrum of bacteria recognition receptors that may be involved in the signaling of the immune responses in the prostate. A few association studies have assessed the relationship between the risk of prostate cancer (PC) and the polymorphism in the TLR4 gene in European-ancestry populations. To evaluate the association of TLR4 polymorphisms and the risk for PC in Korean men, we genotyped five single-nucleotide polymorphisms (SNPs) of the TRL4 gene (rs11536858, rs1927914, 1927911, rs11536891, and rs11536897) by PCR-restriction fragment length polymorphism from unrelated 157 PC patients and 143 age-matched controls. The rs1927911 SNP increased the risk of PC (adjusted odds ratio ORadj=2.73, 95% CI=1.54-4.87 for the TC genotype; ORadj=6.68, 95% CI=3.27-13.66 for the CC genotype). The GG genotype of the rs11536858 SNP also carried increased risk (ORadj=2.296, 95% CI=1.07-4.93). There was no statistically significant correlation between any of the SNPs of TRL4 and such PC prognostic factors as Gleason grade, initial prostate-specific antigen level, or tumor stage. In conclusion, inherited differences in the TLR4 gene influence the risk of PC in Korean men.
Song
Jaemann
J
Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Kim
Duk Yoon
DY
Kim
Choung Soo
CS
Kim
Hyung Jin
HJ
Lee
Dong Hyeon
DH
Lee
Hyun Moo
HM
Ko
Woojin
W
Lee
Gilho
G
D000368:Aged; D044466:Asian People / Q000235:genetics; D006801:Humans; D007723:Korea; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D051197:Toll-Like Receptor 4 / Q000235:genetics* / Q000378:metabolism
C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4