Transcriptional regulation of hepatic stellate cells.
Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which, upon liver injury, the quiescent vitamin A storing perisinusoidal HSC is converted into a wound-healing myofibroblast and acquires potent pro-inflammatory and pro-fibrogenic activities. This remarkable phenotypic transformation is underpinned by changes in the expression of a vast number of genes. In this review we survey current knowledge of the transcription factors that either control HSC activation or which regulate specific fibrogenic functions of the activated HSC such as collagen expression, proliferation and resistance to apoptosis.
Mann
Jelena
J
Liver Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. jelena.mann@ncl.ac.uk
Mann
Derek A
DA
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D015316:Genetic Therapy; D022781:Hepatocytes / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics / Q000473:pathology; D008107:Liver Diseases / Q000235:genetics / Q000473:pathology; D014157:Transcription Factors
D014157:Transcription Factors