Mechanisms and results of the antibody-dependent enhancement  of viral infections and role in the pathogenesis  of coxsackievirus B-induced diseases.
The mechanisms of the antibody-dependent enhancement (ADE) of viral infection are presented, particularly within the Picornaviridae family. The ADE of infection has been described in both human and animal models, worsens viral infections and compromises vaccine safety. The ADE of coxsackievirus B infection can also be implied in the pathogenesis of diseases like chronic dilated cardiomyopathy or insulin-dependent type 1 diabetes.
Sauter
Pierre
P
Laboratoire de virologie/UPRES EA3610, Faculté de médecine, Université Lille-2, CHRU de Lille, Centre de Biologie et Parc Eurasanté, Lille 59037, France
Hober
Didier
D
D000818:Animals; D019067:Antibody-Dependent Enhancement; D002311:Cardiomyopathy, Dilated / Q000209:etiology*; D003384:Coxsackievirus Infections / Q000150:complications* / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D029822:Enterovirus B, Human / Q000276:immunology*; D006801:Humans