Standards for PET image acquisition and quantitative data analysis.
Quantitative (18)F-FDG PET is increasingly being recognized as an important tool for diagnosis, determination of prognosis, and response monitoring in oncology. However, PET quantification with, for example, standardized uptake values (SUVs) is affected by many technical and physiologic factors. As a result, some of the variations in the literature on SUV-based patient outcomes are explained by differences in (18)F-FDG PET study methods. Various technical and clinical studies have been performed to understand the factors affecting PET quantification. On the basis of the results of those studies, several recommendations and guidelines have been proposed with the aims of improving the image quality and the quantitative accuracy of (18)F-FDG PET studies. In this contribution, an overview of recommendations and guidelines for quantitative (18)F-FDG PET studies in oncology is provided. Special attention is given to the rationale underlying certain recommendations and to some of the differences in various guidelines.
Boellaard
Ronald
R
Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands. r.boellaard@vumc.nl
D019788:Fluorodeoxyglucose F18; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000592:standards*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D049268:Positron-Emission Tomography / Q000379:methods* / Q000592:standards*; D017410:Practice Guidelines as Topic; D019275:Radiopharmaceuticals; D013382:Subtraction Technique; D016896:Treatment Outcome
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18