Role of platelet electron microscopy in the diagnosis of platelet disorders.
The electron microscope has proved to be a useful tool to study and understand the biology of platelets and to classify many platelet disorders. After a technical overview, this article reviews syndromes originating from platelet organelle, cytoskeleton, and membrane defects for which electron microscopy plays a role in the diagnostic process, such as gray platelet syndrome, Paris-Trousseau syndrome, storage pool diseases, MYH9-related thrombocytopenias, or Wiskott-Aldrich syndrome. Particular focus is given to the ultrastructural aspect of platelets in these disorders.
Clauser
Sylvain
S
Service d'Hématologie-Immunologie, Hôpital Ambroise Paré, Assistance Publique-Hôpitaux de Paris, 9 avenue Charles de Gaulle, Boulogne-Billancourt, France.
Cramer-Bordé
Elisabeth
E
D001791:Blood Platelet Disorders / Q000097:blood* / Q000175:diagnosis*; D001792:Blood Platelets / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D046529:Microscopy, Electron, Transmission / Q000379:methods*