Role of ischemic preconditioning in liver surgery and hepatic transplantation.
BACKGROUND
The purpose of this review is to summarize intraoperative surgical strategies available to decrease ischemia-reperfusion injury associated with liver resection and liver transplantation.


METHODS
We conducted a critical review of the literature evaluating the potential applications of hepatic ischemic preconditioning (IPC) for hepatic resection surgery and liver transplantation. In addition, we provide a basic bench-to-bedside summary of the liver physiology and cell signaling mechanisms that account for the protective effects seen with hepatic IPC.
Montalvo-Jave
Eduardo E
EE
Departamento de Cirugía, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM) y Servicio de Cirugía General del Hospital General de México, Mexico City, Mexico.
Piña
Enrique
E
Montalvo-Arenas
Cesar
C
Urrutia
Raúl
R
Benavente-Chenhalls
Luis
L
Peña-Sanchez
Julieta
J
Geller
David A
DA
D000818:Animals; D005234:Fatty Liver / Q000503:physiopathology; D006498:Hepatectomy; D022781:Hepatocytes / Q000502:physiology; D006801:Humans; D019194:Ischemic Preconditioning / Q000379:methods; D008099:Liver / Q000503:physiopathology; D008102:Liver Circulation; D016031:Liver Transplantation / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism; D011300:Preoperative Care; D012039:Regional Blood Flow; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control
D009569:Nitric Oxide