title: A comparison between the transfer function of ABP to ICP and compensatory reserve index in TBI.
abstract: BACKGROUND
  The transfer functions which map the arterial blood pressure to the intracranial pressure and the compensatory reserve index have been investigated by various groups to evaluate the brain compliance of patients with traumatic brain injury. The focus of this study has been to assess the capability of both the above mentioned methods to monitor the intracranial compliance in patients suffering from brain swelling.
  
  
  METHODS
  Clinical data was collected from sixteen traumatic brain injury patients and split into 4 min segments. For each segment, both the magnitude of the empirical transfer function at the fundamental cardiac frequency and the compensatory reserve index were extracted.
  
  
  RESULTS
  The mean values of the compensatory reserve index and the magnitude of the transfer function which scored higher than 0.7 and 0.1 respectively were recorded for all patients suffering from brain swelling. By comparing the histogram of the magnitude of the transfer function at the fundamental cardiac frequency with the histogram of the compensatory reserve index for all patients, a positive correlation between the mean values and a negative correlation among their variances were observed. The linear correlation between the mean values was estimated at r = 0.82 (p < 0.0001).
  
  
  CONCLUSIONS
  These observations suggest that to evaluate the intracranial compensatory reserve, the magnitude of 0.1 could be a useful threshold for the transfer function at the fundamental cardiac frequency.
authors.affiliation: Department of Signals and Systems, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden. shahsava@chalmers.se
authors.forename: Sima
authors.initials: S
authors.lastname: Shahsavari
authors.forename: Tomas
authors.initials: T
authors.lastname: McKelvey
authors.forename: Thomas
authors.initials: T
authors.lastname: Skoglund
authors.forename: Catherine Eriksson
authors.initials: CE
authors.lastname: Ritzèn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D001930:Brain Injuries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors; D055815:Young Adult