title: Acute effects of positive end-expiratory pressure on left ventricle diastolic function in healthy subjects.
abstract: We evaluated the acute effect of the application of positive end-expiratory pressure (PEEP) on LV diastolic function in 10 healthy subjects. We assessed load dependent diastolic function by Doppler examination of transmitral flow and load independent diastolic function by color M-mode propagation velocity of early flow into the LV cavity (Vp). During the application of PEEP in comparison to the baseline, we found a significant reduction of the E wave peak velocity [79 (64-83) vs. 65 (57-72) cm/s; p = 0.028] and a significant reduction in Vp [84 (73-97) vs. 53 (48-66); p = 0.012]. Moreover, we found a significant reduction in left atrial area [15 (13-18) vs. 12 (10-14) cm(2); p = 0.018] and right atrial area [12 (11-15) vs. 11 (9-12) cm(2); p = 0.015]. No difference was found in global LV systolic function. The application of PEEP acutely modifies the diastolic flow pattern across the mitral valve, and reduces atrial dimensions.
authors.affiliation: U.O. Cardiologia, P.C. Carate B-Giussano, Azienda Ospedaliera di Desio e Vimercate, Via Milano 65, Giussano, 20038 Milan, Italy. alberto.maestroni@tiscali.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Maestroni
authors.forename: Stefano
authors.initials: S
authors.lastname: Aliberti
authors.forename: Omar
authors.initials: O
authors.lastname: Amir
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Milani
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Brambilla
authors.forename: Federico
authors.initials: F
authors.lastname: Piffer
authors.forename: Francesca
authors.initials: F
authors.lastname: Tardini
authors.forename: Roberto
authors.initials: R
authors.lastname: Cosentini
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000000981:diagnostic imaging; D010865:Pilot Projects; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000209:etiology*