Effect of conventional antihypertensive drugs on hypolipidemic action of garlic in rats.
The present study was undertaken to determine the possible alteration in hypolipidemic actions of garlic homogenate (GH) in presence of conventional antihypertensive drugs, propranolol (PRO), hydrochlorothiazide (HYD) and captopril (CAP). Albino rats fed with normal fat diet (NFD) or high fat diet (HFD) were treated with GH at three different doses (125, 250 and 500 mg/kg) orally for 30 days or in combination with PRO (10 mg/kg, po), HYD (10 mg/kg, po) and CAP (30 mg/kg, po) during last 7 days of GH treatment. After the treatment, total cholesterol (TC), LDL-cholesterol, triglyceride (TG) and HDL-cholesterol were measured in serum and antiatherogenic index was calculated. The result showed that moderate and high doses of GH possessed potential antiatherosclerotic property that was significantly attenuated by PRO and HYD. However, GH antihyperlipidemic activity was augmented by CAP. It was concluded that administration of PRO and HYD decrease the hypolipidemic effect of GH and administration of GH along with CAP augmented the hypolipidemic effect of GH in rats.
Asdaq
Syed Mohammed Basheeruddin
SM
Department of Pharmacology, Krupanidhi College of Pharmacy, # 5, Sarjapur Road, Koramangala, Bangalore 560 034, India. basheer_1@rediffmail.com
Inamdar
Mohammed Naseeruddin
MN
Asad
Mohammed
M
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D004036:Diet, Atherogenic; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005737:Garlic / Q000737:chemistry*; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts