Pediatric multicentric glioma occurring after cranial irradiation.
An 8-year-old girl with no family history of neoplasia underwent biopsy and chemoradiation therapy for a suprasellar mixed germ cell tumor, which resulted in complete remission. A surveillance MRI taken 37 months after irradiation detected a non-enhancing mass in the genu of the corpus callosum. MRI taken 42 months after irradiation revealed significant growth of the mass and a new enhancing lesion in the temporal lobe, which showed rapid growth over 3 weeks. Subtotal resection and biopsy were performed on the lesions in the temporal lobe and the corpus callosum, respectively. Histological examination revealed that the temporal tumor was a glioblastoma multiforme and the frontal lesion was a diffuse astrocytoma. These tumors had newly developed within the irradiated field, but were separated in both location and time. Radiation-induced gliomas may develop within a shorter time interval than previously considered.
Tsutsumi
Satoshi
S
Department of Neurological Surgery, Juntendo University Urayasu Hospital, Tomioka, Urayasu, Japan. shotaro@juntendo-urayasu.jp
Yasumoto
Yukimasa
Y
Ito
Masanori
M
D001254:Astrocytoma / Q000473:pathology* / Q000601:surgery; D001921:Brain / Q000473:pathology / Q000528:radiation effects; D001932:Brain Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D002648:Child; D017809:Fatal Outcome; D005260:Female; D005909:Glioblastoma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D009373:Neoplasms, Germ Cell and Embryonal / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000601:surgery