Positive effects of green tea on hepatic dysfunction, lipid peroxidation and antioxidant defence depletion induced by cadmium.
Cadmium (Cd) is a highly toxic environmental and industrial cumulative pollutant that affects many organs, especially the liver. The present study was designed to evaluate the antioxidant effect of green tea on cadmium-induced hepatic dysfunction and oxidative stress in rats. Adult male Wistar rats were administered cadmium by injection of 20 micromoles/kg bw/every 3 days for six months. This study revealed significant (p < 0.05) liver dysfunction, lipid peroxidation and a decline in antioxidant enzyme activities in the liver of cadmium-treated rats compared to control animals. Compared to control rats, the activities of lactate dehydrogenase (LDH), gammaglutamyl transferase (GGT), acid phosphatase (PAC), phosphatase alkaline (PAL), as well as bilirubin and thiobarbituric acid-reactive substances (TBARs), were significantly (p < 0.05) increased in Cd-treated rats. Moreover, antioxidant enzyme activities, such as superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase, were significantly (p < 0.05) decreased in the liver of cadmium-treated rats. The oral administration of 5% aqueous green tea extract, along with cadmium treatment for six months, caused a significant (p < 0.05) improvement in cadmium-induced toxicity by significantly decreasing (p < 0.05) the activities of enzymatic markers of liver dysfunction (LDH, GGT, PAC, PAL activities, as well as the bilirubin rate). Indeed, green tea extract significantly increased (p < 0.05) antioxidant enzymatic activities (SOD, Catalase, GPX) in rat liver, compared to those given cadmium alone. Thus, the oral administration of green tea, along with cadmium significantly (p < 0.05) improves cadmium-induced liver dysfunction and stress oxidant in rats' liver.
Hamden
Khaled
K
Animal Ecophysiology, Faculty of Sciences, University of Sfax, Tunisia. hamdenkhalid@yahoo.com
Carreau
Serge
S
Marki
Fatma Ayadi
FA
Masmoudi
Hatem
H
El Feki
Abdelfattah
A
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002104:Cadmium / Q000633:toxicity*; D028241:Camellia sinensis / Q000737:chemistry*; D056486:Chemical and Drug Induced Liver Injury; D016166:Free Radical Scavengers; D015227:Lipid Peroxidation / Q000187:drug effects*; D008107:Liver Diseases / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013662:Tea
D000975:Antioxidants; D015415:Biomarkers; D016166:Free Radical Scavengers; D013662:Tea; D002104:Cadmium