Fluorenone alkaloid from Caulophyllum robustum Maxim. with anti-myocardial ischemia activity.
A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustum Maxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.
Wang
Sicen
S
School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.
Wen
Binyu
B
Wang
Na
N
Liu
Juntian
J
He
Langchong
L
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002317:Cardiovascular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028145:Caulophyllum / Q000737:chemistry; D002845:Chromatography / Q000379:methods; D004195:Disease Models, Animal; D005449:Fluorenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D009203:Myocardial Infarction / Q000473:pathology / Q000517:prevention & control*; D017202:Myocardial Ischemia / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000470:Alkaloids; D002317:Cardiovascular Agents; D005449:Fluorenes