Highly enantio- and diastereoselective organocatalytic desymmetrization of prochiral cyclohexanones by simple direct aldol reaction catalyzed by proline.
Companyó
Xavier
X
Departament de Química Orgànica, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain.
Valero
Guillem
G
Crovetto
Luis
L
Moyano
Albert
A
Rios
Ramon
R
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D003512:Cyclohexanones / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D003512:Cyclohexanones; C116609:3-hydroxybutanal; D011392:Proline