title: [Biology of arterial ageing and arteriosclerosis].
abstract: Arterial ageing - arteriosclerosis - is characterised by both thickening and stiffening of the walls of large and medium arteries. The molecular and cellular mechanisms (i.e. endothelial dysfunction, matrix remodelling, ...) involved in this process are complex, and at least in part common to atherosclerotic injury. Arterial stiffness is strongly associated with cardiovascular disease and an increased risk of morbidity and mortality. The aim of this review is to provide an update on the pathophysiology and the biological process of arterial ageing and to underline the main difference with atherosclerosis damage process in particularly during the calcification step.
authors.affiliation: APHP, Hôpital Charles-Foix, Ivry sur Seine, France. charles-henry.cottart@cfx.aphp.fr
authors.forename: Charles-Henry
authors.initials: CH
authors.lastname: Cottart
authors.forename: Christelle
authors.initials: C
authors.lastname: Laguillier
authors.forename: Valérie
authors.initials: V
authors.lastname: Nivet-Antoine
authors.forename: Christophe
authors.initials: C
authors.lastname: Klimczak
authors.forename: Claude
authors.initials: C
authors.lastname: Sebban
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Beaudeux
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D001120:Arginine / Q000031:analogs & derivatives / Q000378:metabolism; D001161:Arteriosclerosis / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D050197:Atherosclerosis / Q000503:physiopathology; D002114:Calcinosis / Q000503:physiopathology; D003935:Diagnostic Techniques, Cardiovascular; D004730:Endothelium, Vascular / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology; D010006:Osteoblasts / Q000502:physiology; D017540:Tunica Media / Q000473:pathology; D014655:Vascular Resistance
chemical_list: D008074:Lipoproteins; C018524:N,N-dimethylarginine; D001120:Arginine