Bone mineral density, arterial stiffness, and coronary atherosclerosis in healthy postmenopausal women.
OBJECTIVE
The aim of this study was to assess the correlation between bone mineral density (BMD), arterial stiffness, and coronary atherosclerosis in healthy postmenopausal women.


METHODS
We performed a retrospective review of 152 postmenopausal women who visited the health promotion center for a routine checkup, after excluding participants who had factors affecting BMD and coronary artery disease. BMD was evaluated by dual-energy x-ray absorptiometry in the lumbar spine and femur. Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV), and coronary atherosclerosis was assessed by 64-row multidetector computed tomography.


RESULTS
Women with osteoporosis had a significantly higher baPWV than those in the osteopenia and normal BMD groups. Higher baPWV was also associated with the presence of atherosclerosis. The baPWV was significantly positively correlated with age, systolic blood pressure, diastolic blood pressure, and neutrophil to lymphocyte ratio and negatively correlated with femur BMD. The optimum predictive value of baPWV in coronary atherosclerosis was estimated using the receiver operating characteristic curve. A cutoff of 1,506 cm/second would give a sensitivity of 83.3% and specificity of 82.9%. A higher overall risk for coronary atherosclerosis emerges with higher baPWV levels (>1,500 cm/s) after controlling for age and cardiovascular risk factors.


CONCLUSIONS
Arterial stiffness by measuring baPWV can be a useful independent predictor for coronary atherosclerosis. In addition, our results suggest that postmenopausal women with osteoporosis should be considered for further evaluation of coronary atherosclerosis.
Seo
Seok Kyo
SK
Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Seoul, Korea.
Cho
SiHyun
S
Kim
Hye Yeon
HY
Choi
Young Sik
YS
Park
Ki Hyun
KH
Cho
Dong Jae
DJ
Lee
Byung Seok
BS
D015502:Absorptiometry, Photon / Q000379:methods / Q000592:standards; D000704:Analysis of Variance; D055109:Ankle Brachial Index / Q000379:methods* / Q000592:standards; D015519:Bone Density / Q000502:physiology*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D006801:Humans; D007723:Korea / Q000453:epidemiology; D016015:Logistic Models; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008403:Mass Screening / Q000379:methods* / Q000592:standards; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology*; D017698:Postmenopause / Q000502:physiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000592:standards; D014655:Vascular Resistance / Q000502:physiology