Usefulness of basal B-type natriuretic peptide levels for the diagnosis of diastolic heart failure in young patients: an echocardiographic-catheterization study.
The aim of the present study was to address the diagnostic relevance of B-type natriuretic peptide (BNP) for the diagnosis of diastolic heart failure (DHF) in young patients presenting with chronic, isolated dyspnea. We prospectively included 26 consecutive patients with a left ventricular ejection fraction >50% referred for catheterism. DHF was authenticated in 15 patients with an invasive left ventricular end-diastolic pressure >16 mmHg. By logistic regression analysis, BNP was predictive of DHF (p=0.03). A cut-off value of 31 pg/ml was 67% sensitive and 73% specific for the diagnosis (area under the ROC curve of 0.76 [0.55-0.9], p=0.007).
Arques
Stephane
S
Jaubert
Marie-Perrine
MP
Bonello
Laurent
L
Roux
Emmanuel
E
Armero
Sebastien
S
Sbragia
Pascal
P
Nicoud
Alexane
A
Paganelli
Franck
F
D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D006328:Cardiac Catheterization / Q000379:methods*; D004452:Echocardiography / Q000379:methods; D005260:Female; D054144:Heart Failure, Diastolic / Q000097:blood* / Q000000981:diagnostic imaging* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain