Deep brain stimulation of the posterior hypothalamic nucleus reverses akinesia in bilaterally 6-hydroxydopamine-lesioned rats.
Deep brain stimulation (DBS) of the basal ganglia motor circuitry is a highly effective treatment for the debilitating motor symptoms of Parkinson's disease (PD). However, recent findings have indicated promising potential for PD therapy with DBS in brain structures outside the basal ganglia. For example, high frequency stimulation of the posterior hypothalamic nucleus (PH) can reverse haloperidol-induced akinesia in rats [Jackson J, Young CK, Hu B, Bland BH (2008) High frequency stimulation of the posterior hypothalamic nucleus restores movement and reinstates hippocampal-striatal theta coherence following haloperidol-induced catalepsy. Exp Neurol 213:210-219]. In the current study, we used the bilateral 6-hydroxydopamine lesion model of Parkinsonian akinesia in male Long-Evans rats to further explore the efficacy of PH DBS. The application of PH DBS in lesioned animals reversed akinesia in an active avoidance paradigm with increased latency compared to pre-lesion performance. The dramatic reversal of akinesia in two models of rodent Parkinsonism by PH DBS warrants further exploration of its therapeutic potential.
Young
C K
CK
Department of Psychology, Behavioral Neuroscience Research Group, Hotchkiss Brain Institute, University of Calgary, 2500 University Drive Northwest, Calgary ABT2N1N4, Canada.
Koke
S J
SJ
Kiss
Z H
ZH
Bland
B H
BH
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D002404:Catheterization; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted; D004597:Electroshock; D007034:Hypothalamus, Posterior / Q000503:physiopathology*; D008297:Male; D009069:Movement Disorders / Q000209:etiology / Q000628:therapy*; D016627:Oxidopamine; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time
D016627:Oxidopamine