title: Association of TLR4 polymorphisms with Behcet's disease in a Korean population.
abstract: OBJECTIVE
  HLA-B51 is strongly associated with Behçet's disease (BD) in any ethnic background. We recently reported that another gene, Toll-like receptor-4 (TLR4) is also implicated in BD in a Japanese population. To confirm these results, we investigated polymorphisms in the TLR4 gene in Korean patients with BD.
  
  
  METHODS
  In this study, 119 patients with BD and 141 healthy controls were enrolled; every participant was a Korean. Nine single nucleotide polymorphisms previously detected in TLR4 by direct sequencing were analysed for an association with BD.
  
  
  RESULTS
  The most frequent haplotype, TAGCGGTAA, was significantly increased in HLA-B*51-positive BD patients (49.5%), compared with healthy control participants [32.3%; P = 0.029; odds ratio (OR) = 2.01; 95% CI 1.25-3.23]. This haplotype was also significantly increased in BD patients with arthritis (48.2%; P = 0.003; OR = 1.96; 95% CI 1.26-3.26). There were no significant differences in the allele and genotype frequencies of patients and controls for each single nucleotide polymorphism.
  
  
  CONCLUSIONS
  The haplotype of TLR4 may increase the risk for developing BD and the complication of arthritis in the Korean population.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Horie
authors.forename: Akira
authors.initials: A
authors.lastname: Meguro
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kitaichi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Katsuyama
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Namba
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yoshida
authors.forename: Yeong Wook
authors.initials: YW
authors.lastname: Song
authors.forename: Kyung Sook
authors.initials: KS
authors.lastname: Park
authors.forename: Eun Bong
authors.initials: EB
authors.lastname: Lee
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Mizuki
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
mesh_terms: D001168:Arthritis / Q000150:complications / Q000235:genetics / Q000276:immunology; D001483:Base Sequence; D001528:Behcet Syndrome / Q000150:complications / Q000235:genetics* / Q000276:immunology*; D016022:Case-Control Studies; D015342:DNA Probes / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000276:immunology; D059949:HLA-B51 Antigen; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008297:Male; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D051197:Toll-Like Receptor 4 / Q000235:genetics*
chemical_list: D015342:DNA Probes; D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4