title: [Prevalence of chromosomal alterations in infertile patients studied in a clinic of assisted reproduction].
abstract: BACKGROUND
  Chromosomal abnormalities are a frequent cause of infertility. There is not consensus if should be included in the work-up of infertile couple.
  
  
  OBJECTIVE
  to evaluate the prevalence of chromosomal abnormalities in our population of infertile couple and support the cytogenetic exam in the initial protocol.
  
  
  METHODS
  Retrospective study of 787 infertile patients divided in five groups, to whom a cytogenetic exam was performed between January 2004 and April 2007.
  
  
  RESULTS
  The prevalence of general chromosomal abnormalities was 12.5% (98/787). We found a 14.8% (34/229) with severe male factor, 14.3% (2/14) with premature ovarian failure, 12.3% (20/162) with recurrent pregnancy loss, 8% (9/112) idiopathic infertility and 12.2% (33/270) associated with other causes. The major alterations correspond to trisomies, translocations, and 9 chromosome markers.
  
  
  CONCLUSIONS
  The results of this study are consistent with those reported in the literature which are associated with a greater prevalence of chromosomal abnormalities in infertile couples compared with the general population, this findings show the importance of consider the cytogenetic study in the initial diagnosis protocol of infertile couple.
authors.affiliation: Instituto Médica Fértil Querétaro, Querétaro.
authors.forename: Sergio
authors.initials: S
authors.lastname: Romero Tovar
authors.forename: Berenice
authors.initials: B
authors.lastname: Juárez Espinosa
authors.forename: Carlos G
authors.initials: CG
authors.lastname: Galindo García
authors.forename: Margarita
authors.initials: M
authors.lastname: Mendoza Romo
authors.forename: Rafael A
authors.initials: RA
authors.lastname: Sánchez Usabiaga
mesh_terms: D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D005260:Female; D006268:Health Facilities; D006801:Humans; D007246:Infertility / Q000235:genetics*; D008297:Male; D015995:Prevalence; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies