title: Biosensing by densely packed and optically coupled plasmonic particle arrays.
abstract: Densely packed plasmonic particle arrays are investigated for biosensing applications. Such particle arrays exhibit interparticle optical coupling creating a strong field between the particles, which is useful for sensing purposes. The sensor properties, such as bulk sensitivity, layer sensitivity, and the depth of sensitivity are investigated with the aid of a multiple multipole program. Sensitivity to the analyte with low concentration is also examined by a dynamic adsorption processes. The detectable concentration limit of streptavidin within 3000 s in the detection system is expected from the signal-to-noise to be less than 150 pM.
authors.affiliation: Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Gloriastrasse 35, 8092 Zurich, Switzerland.
authors.forename: Takumi
authors.initials: T
authors.lastname: Sannomiya
authors.forename: Pratap K
authors.initials: PK
authors.lastname: Sahoo
authors.forename: Davut I
authors.initials: DI
authors.lastname: Mahcicek
authors.forename: Harun H
authors.initials: HH
authors.lastname: Solak
authors.forename: Christian
authors.initials: C
authors.lastname: Hafner
authors.forename: Dorothee
authors.initials: D
authors.lastname: Grieshaber
authors.forename: Janos
authors.initials: J
authors.lastname: Vörös
mesh_terms: D000327:Adsorption; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D006046:Gold / Q000737:chemistry; D007700:Kinetics; D053768:Metal Nanoparticles / Q000737:chemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods; D055095:Optics and Photonics; D012997:Solvents / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D019809:Streptavidin / Q000737:chemistry*; D020349:Surface Plasmon Resonance; D013997:Time Factors
chemical_list: D012997:Solvents; D006046:Gold; D019809:Streptavidin