Expression of stem cell pluripotency factors during regeneration in newts.
In this study, we present data indicating that mammalian stem cell pluripotency-inducing factors are expressed during lens and limb regeneration in newts. The apparent expression even in intact tissues and the ensued regulation during regeneration raises the possibility that these factors might regulate tissue-specific reprogramming and regeneration. Furthermore, these factors should enable us to understand the similarities and differences between animal regeneration in the newt and stem cell strategies in mammals. Developmental Dynamics 238:1613-1616, 2009. (c) 2009 Wiley-Liss, Inc.
Maki
Nobuyasu
N
Department of Biology and Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton, Ohio, USA.
Suetsugu-Maki
Rinako
R
Tarui
Hiroshi
H
Agata
Kiyokazu
K
Del Rio-Tsonis
Katia
K
Tsonis
Panagiotis A
PA
D000818:Animals; D005121:Extremities / Q000033:anatomy & histology / Q000502:physiology; D018398:Homeodomain Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000502:physiology; D050814:Octamer Transcription Factor-3 / Q000145:classification / Q000235:genetics / Q000378:metabolism; D010802:Phylogeny; D039904:Pluripotent Stem Cells / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D012455:Salamandridae / Q000033:anatomy & histology / Q000502:physiology
D018398:Homeodomain Proteins; D050814:Octamer Transcription Factor-3