Wound healing with PRGF infiltration in CO(2) laser lesions of the tongue: an animal study.
OBJECTIVE
This study was done of the effects of plasma rich in growth factors (PRGF) on the healing of tongue wounds induced by the CO(2) laser.


METHODS
A prospective blind study was made of 60 Sprague-Dawley rats divided into two groups after the creation of tongue lesions using the CO(2) laser. Nothing was applied to the resulting wounds in the first group, while PRGF was applied to the 30 wounds in the second group. Wound re-epithelialization and inflammation were measured after 7, 14, and 28 d.


RESULTS
No significant differences were seen between the two groups in relation to wound re-epithelialization, and the group without PRGF actually showed significantly better resolution of the inflammatory process after 14 d (p = 0.036).


CONCLUSIONS
After 28 d, the rat tongue wounds produced by the CO(2) laser showed complete healing, independently of PRGF application.
Camacho-Alonso
Fabio
F
Department of Oral Medicine, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain. fcamacho@um.es
López-Jornet
Pía
P
Jiménez-Torres
María José
MJ
Orduña-Domingo
Albina
A
D000818:Animals; D002245:Carbon Dioxide; D004195:Disease Models, Animal; D007249:Inflammation; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D007834:Lasers; D008297:Male; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D051381:Rats; D017207:Rats, Sprague-Dawley; D014059:Tongue / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects*
D036341:Intercellular Signaling Peptides and Proteins; D002245:Carbon Dioxide