[Modulation of Kv4 channels by KChIPs clamping].
The rapidly inactivating (A-type) potassium channels regulate membrane excitability that defines the fundamental mechanism of neuronal functions such as pain signaling. Cytosolic Kv channel-interacting proteins KChIPs co-assemble with Kv4 (Shal) alpha subunits to form a native complex. The specific binding of auxiliary KChIPs to the Kv4 N-terminus results in modulation of gating properties, surface expression and subunit assembly of Kv4 channels. Based on recent structural efforts, here we attempt to emphasize the interaction between KChIPs and Kv4 channel complex in which a single KChIP1 molecule laterally clamps two neighboring Kv4.3 N-termini in a 4:4 manner. Greater insights into molecular mechanism between KChIPs and Kv4 interaction may provide therapeutic potentials by structure-based design of chemical compounds aimed at disrupting the protein-protein interaction for treatment of membrane excitability-related disorders.
Cui
Yuan-Yuan
YY
Neuroscience Research Institute, Department of Neurobiology, Peking University Health Science Center, Beijing 100191, China.
Wang
Ke-Wei
KW
D000818:Animals; D051605:Kv Channel-Interacting Proteins / Q000378:metabolism*; D021122:Protein Subunits; D051672:Shal Potassium Channels / Q000378:metabolism*
D051605:Kv Channel-Interacting Proteins; D021122:Protein Subunits; D051672:Shal Potassium Channels