title: Spontaneous ganglioneuroma possibly originating from the trigeminal ganglion in a B6C3F1 mouse.
abstract: In a carcinogenicity study, a neuronal tumor in the cranial cavity was observed in a 110-week-old female B6C3F1 mouse. At necropsy, the tumor was seen at the site of the pituitary gland. Histologically, the tumor consisted of well-differentiated ganglion cells, nerve fiber/neuropil-like elements and ganglion-like cells. The tumor was composed mainly of ganglion-like cells, which were arranged in solid sheets interspersed with thin fibrovascular stroma. Nissl substance was detected at the margin in the cytoplasm of well-differentiated ganglion cells, and nerve fibers were identified by the Kluever-Barrera method. Immunohistochemically, the well-differentiated ganglion cells were positive for S-100, neurofilament protein (NF), neuron-specific enolase (NSE), synaptophysin, and chromogranin A. The nerve fiber/neuropil-like elements were positive for S-100, NF, NSE, and glial fibrillary acidic protein (GFAP), and the ganglion-like cells were strongly positive only for NSE and synaptophysin. On the other hand, there were no pituitary cells, such as prolactin-positive or adrenocorticotropic hormone (ACTH)-positive cells in the tumor tissue. Detailed histopathological examination suggested that the tumor might be a ganglioneuroma arising from the trigeminal ganglion. This report provides additional histopathological evidence of peripheral nerve neoplasms in mice.
authors.affiliation: Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan.
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Yasui
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Ohta
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Ueda
authors.forename: Kazushige
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Tohru
authors.initials: T
authors.lastname: Kihara
authors.forename: Masayo
authors.initials: M
authors.lastname: Hosoi
authors.forename: Rumiko
authors.initials: R
authors.lastname: Miyajima
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shiga
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Imai
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Toyoda
mesh_terms: D000818:Animals; D053379:Chromogranin A / Q000378:metabolism; D005260:Female; D005729:Ganglioneuroma / Q000737:chemistry / Q000473:pathology* / Q000662:veterinary*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D051379:Mice; D008815:Mice, Inbred Strains; D016900:Neurofilament Proteins / Q000378:metabolism; D009562:Nissl Bodies / Q000737:chemistry; D010524:Peripheral Nervous System Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D012376:Rodent Diseases / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism; D012668:Trigeminal Ganglion / Q000473:pathology*
chemical_list: D053379:Chromogranin A; D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins; D009418:S100 Proteins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase