title: Alignment-free comparison of protein sequences based on reduced amino acid alphabets.
abstract: Protein sequences are treated as stochastic processes on the basis of a reduced amino acid alphabet of 10 types of amino acids. The realization of a stochastic process is described by associated transition probability matrix that corresponds to the process uniquely. Then new distances between transition probability matrices are defined for sequences similarity analysis. Two separate datasets are prepared and tested to identify the validity of the method. The results demonstrate the new method is powerful and efficient.
authors.affiliation: Department of Mathematics, Northeast University, Shenyang 110004, China. cangzhijia@yahoo.com.cn
authors.forename: Cangzhi
authors.initials: C
authors.lastname: Jia
authors.forename: Tian
authors.initials: T
authors.lastname: Liu
authors.forename: Xiangde
authors.initials: X
authors.lastname: Zhang
authors.forename: Haoyue
authors.initials: H
authors.lastname: Fu
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis* / Q000235:genetics; D000818:Animals; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis / Q000145:classification / Q000235:genetics; D008969:Molecular Sequence Data; D010802:Phylogeny; D011506:Proteins / Q000032:analysis* / Q000145:classification / Q000235:genetics; D015203:Reproducibility of Results; D016415:Sequence Alignment / Q000379:methods*; D064370:Spike Glycoprotein, Coronavirus; D014168:Transferrin / Q000032:analysis / Q000145:classification / Q000235:genetics; D014759:Viral Envelope Proteins / Q000032:analysis / Q000145:classification / Q000235:genetics
chemical_list: D000596:Amino Acids; D008562:Membrane Glycoproteins; D011506:Proteins; D064370:Spike Glycoprotein, Coronavirus; D014168:Transferrin; D014759:Viral Envelope Proteins