Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy.
The purpose of this study is to assess the clinical value of spatiotemporal source analysis for analyzing ictal magnetoencephalography (MEG). Ictal MEG and simultaneous scalp EEG was recorded in five patients with medically intractable frontal lobe epilepsy. Dynamic statistical parametric maps (dSPMs) were calculated at the peak of early ictal spikes for the purpose of estimating the spatiotemporal cortical source distribution. DSPM solutions were mapped onto a cortical surface, which was derived from each patient's MRI. Equivalent current dipoles (ECDs) were calculated using a single-dipole model for comparison with dSPMs. In all patients, dSPMs tended to have a localized activation, consistent with the clinically determined ictal onset zone, whereas most ECDs were considered to be inappropriate sources according to their goodness-of-fit values. Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy.
Tanaka
Naoaki
N
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. naoro@nmr.mgh.harvard.edu
Cole
Andrew J
AJ
von Pechmann
Deidre
D
Wakeman
Daniel G
DG
Hämäläinen
Matti S
MS
Liu
Hesheng
H
Madsen
Joseph R
JR
Bourgeois
Blaise F
BF
Stufflebeam
Steven M
SM
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000002:abnormalities / Q000601:surgery; D003627:Data Interpretation, Statistical; D004351:Drug Resistance; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography / Q000706:statistics & numerical data*; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications; D012189:Retrospective Studies; D055815:Young Adult
D000927:Anticonvulsants