Subtyping and env C2/V3 sequence analysis of HIV-1 isolated from HIV-infected children hospitalized in Children Hospital 1, Vietnam during 2004-2005.
A molecular epidemiological study was conducted on 104 HIV-1 strains isolated from HIV-infected children hospitalized in Children Hospital 1 in Ho Chi Minh City, Vietnam during 2004-2005. Genetic subtyping based on env C2/V3 sequences revealed that CRF01-AE was the sole circulating recombinant form found in this study. Sequence analysis of the V3 loop showed that GPGQ tetramer was the most common V3 loop core motif identified in the HIV-1 strains studied (89.5%). The findings raise great concern about HIV-infected children in Vietnam and provide up-to-date molecular epidemiological information of HIV-1 circulating in Vietnam during the study period.
Trinh
Quang Duy
QD
Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, the University of Tokyo, Japan.
Pham
Ngan Thi Kim
NT
Lam
Bao Quoc
BQ
Le
Thoa Phan Kim
TP
Truong
Khanh Huu
KH
Le
Thinh Quoc
TQ
Vo
Hung Thanh
HT
Tang
Thuong Chi
TC
Ha
Tuan Manh
TM
Izumi
Yasuyuki
Y
Mizuguchi
Masashi
M
Hayakawa
Satoshi
S
Ushijima
Hiroshi
H
D000595:Amino Acid Sequence; D002675:Child, Preschool; D005260:Female; D015752:Genes, env / Q000235:genetics*; D015750:Genes, gag / Q000235:genetics*; D015751:Genes, pol / Q000235:genetics*; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000235:genetics; D016415:Sequence Alignment; D014744:Vietnam / Q000453:epidemiology