title: Ruthenium-catalyzed selective monoamination of vicinal diols.
abstract: The monoamination of vicinal diols in the presence of in situ generated ruthenium catalysts has been investigated. Among the various phosphines tested in combination with [Ru(3)(CO)(12)], N-phenyl-2-(dicyclohexyl-phosphanyl)pyrrole showed the best performance. After optimization of the reaction conditions this system was applied to different secondary amines and anilines as well as a number of vicinal diols. With the exception of ethylene glycol, monoamination of the vicinal diols occurred selectively and the corresponding amino alcohols were obtained in good yields, producing water as the only side product.
authors.affiliation: Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bähn
authors.forename: Annegret
authors.initials: A
authors.lastname: Tillack
authors.forename: Sebastian
authors.initials: S
authors.lastname: Imm
authors.forename: Kathleen
authors.initials: K
authors.lastname: Mevius
authors.forename: Dirk
authors.initials: D
authors.lastname: Michalik
authors.forename: Dirk
authors.initials: D
authors.lastname: Hollmann
authors.forename: Lorenz
authors.initials: L
authors.lastname: Neubert
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000737:chemistry*; D000605:Amino Alcohols / Q000138:chemical synthesis*; D002384:Catalysis; D055772:Green Chemistry Technology / Q000379:methods; D012428:Ruthenium
chemical_list: D000438:Alcohols; D000588:Amines; D000605:Amino Alcohols; D012428:Ruthenium