All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery.
Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
Lee
Jae-Hyun
JH
Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
Lee
Kyuri
K
Moon
Seung Ho
SH
Lee
Yuhan
Y
Park
Tae Gwan
TG
Cheon
Jinwoo
J
D045744:Cell Line, Tumor; D005290:Ferric Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D055785:Gene Knockdown Techniques; D020868:Gene Silencing; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000235:genetics; D009842:Oligopeptides / Q000737:chemistry; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000235:genetics; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014162:Transfection
D005290:Ferric Compounds; D005456:Fluorescent Dyes; D009842:Oligopeptides; D034741:RNA, Small Interfering; C000499:ferric oxide; C047981:arginyl-glycyl-aspartic acid