title: Transcriptional responses of Haemophilus parasuis  to iron-restriction stress in vitro.
abstract: Haemophilus parasuis is the causative agent of Glässer's disease, which is responsible for the increasing economic losses in the pig industry worldwide. In this study, selective capture of transcribed sequences approach was used to investigate the transcriptional responses of H. parasuis to iron-restriction stress. Thirty-six genes were identified to be up-regulated under iron-restricted conditions. Knowledge of the genes involved in adaptation to environments encountered during disease will help understand the mechanisms of pathogenesis for this economically significant bacterium.
authors.affiliation: Division of Animal Infectious Disease, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, 430070 Wuhan, China.
authors.forename: Qiyun
authors.initials: Q
authors.lastname: Xie
authors.forename: Hui
authors.initials: H
authors.lastname: Jin
authors.forename: Rui
authors.initials: R
authors.lastname: Luo
authors.forename: Yun
authors.initials: Y
authors.lastname: Wan
authors.forename: Jie
authors.initials: J
authors.lastname: Chu
authors.forename: Hufeng
authors.initials: H
authors.lastname: Zhou
authors.forename: Bi
authors.initials: B
authors.lastname: Shi
authors.forename: Huanchun
authors.initials: H
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D004926:Escherichia coli; D020869:Gene Expression Profiling; D005798:Genes, Bacterial; D006192:Haemophilus Infections / Q000378:metabolism / Q000469:parasitology*; D044137:Haemophilus parasuis / Q000235:genetics*; D007501:Iron / Q000378:metabolism*; D008969:Molecular Sequence Data; D011994:Recombinant Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013312:Stress, Physiological; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism / Q000469:parasitology; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D011994:Recombinant Proteins; D007501:Iron