title: The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis.
abstract: A survey of individual specimens of northern Papua New Guinea derived Cacospongia mycofijiensis has yielded novel sesquiterpenes, aignopsanoic acid A (1), methyl aignopsanoate A (2), and isoaignopsanoic acid A (3). The structures and absolute configurations of 1-3 were established using NMR data, X-ray crystallography results, and an analysis of CD properties. Two of these metabolites, 1 and 2, were moderately active against Trypanosoma brucei, the parasite responsible for sleeping sickness.
authors.affiliation: Department of Chemistry and Biochemistry & Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA.
authors.forename: Tyler A
authors.initials: TA
authors.lastname: Johnson
authors.forename: Taro
authors.initials: T
authors.lastname: Amagata
authors.forename: Koneni V
authors.initials: KV
authors.lastname: Sashidhara
authors.forename: Allen G
authors.initials: AG
authors.lastname: Oliver
authors.forename: Karen
authors.initials: K
authors.lastname: Tenney
authors.forename: Teatulohi
authors.initials: T
authors.lastname: Matainaho
authors.forename: Kenny Kean-Hooi
authors.initials: KK
authors.lastname: Ang
authors.forename: James H
authors.initials: JH
authors.lastname: McKerrow
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D021261:Parasitic Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014353:Trypanosomiasis, African / Q000188:drug therapy
chemical_list: D012717:Sesquiterpenes; C540379:aignopsanoic acid A; C540380:methyl aignopsanoate A