title: Synthesis and reactivity of novel gamma-phosphate modified ATP analogues.
abstract: We hereby present a simple yet novel chemical synthesis of a family of gamma-modified ATPs bearing functional groups on the gamma-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27(kip1) is also presented.
authors.affiliation: University of Oxford, Chemistry Research Laboratory, Oxford, UK.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Lee
authors.forename: Lucy M
authors.initials: LM
authors.lastname: Elphick
authors.forename: Alexandra A
authors.initials: AA
authors.lastname: Anderson
authors.forename: Laurent
authors.initials: L
authors.lastname: Bonnac
authors.forename: Emma S
authors.initials: ES
authors.lastname: Child
authors.forename: David J
authors.initials: DJ
authors.lastname: Mann
authors.forename: Véronique
authors.initials: V
authors.lastname: Gouverneur
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051357:Cyclin-Dependent Kinase 2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000737:chemistry / Q000378:metabolism; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D047428:Protein Kinase Inhibitors; D050760:Cyclin-Dependent Kinase Inhibitor p27; D000255:Adenosine Triphosphate; D051357:Cyclin-Dependent Kinase 2