title: Determination of the cuticula thickness of human and porcine hairs and their potential influence on the penetration of nanoparticles into the hair follicles.
abstract: An efficient penetration and long-term storage of topically applied substances is important for drug delivery in medical treatment and cosmetics. It has recently become apparent that the hair follicles represent an efficient and long-term reservoir for topically applied substances. It was found that particles sized 300-600 nm penetrate more efficiently into the hair follicles than smaller or larger particles. In the present paper, the hair surface structure of human and porcine hairs was analyzed by electron microscopy. It could be observed that the thickness of the cuticula corresponds to the optimal size of the nanoparticles for penetration into the hair follicles. Additionally, it could be demonstrated that the cuticula of human vellus and terminal hairs were of similar thickness (approx. 530 nm), while the thickness of the cuticula obtained from porcine ear bristles were slightly thinner (approx. 320 nm).
authors.affiliation: Charite-Universitatsmedizin Berlin, Center of Applied Cutaneous Physiology, Department of Dermatology, Berlin, Berlin D-10117, Germany. juergen.lademann@charite.de
authors.forename: Juergen
authors.initials: J
authors.lastname: Lademann
authors.forename: Alexa
authors.initials: A
authors.lastname: Patzelt
authors.forename: Heike
authors.initials: H
authors.lastname: Richter
authors.forename: Christina
authors.initials: C
authors.lastname: Antoniou
authors.forename: Wolfram
authors.initials: W
authors.lastname: Sterry
authors.forename: Fanny
authors.initials: F
authors.lastname: Knorr
mesh_terms: D000818:Animals; D006197:Hair / Q000737:chemistry* / Q000648:ultrastructure*; D006801:Humans; D066298:In Vitro Techniques; D053758:Nanoparticles / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure*; D013552:Swine