title: Age-related changes in BAER at different click rates from neonates to adults.
abstract: OBJECTIVE
  To characterize age-related changes in brainstem auditory evoked response (BAER) at different click rates from neonates to adults.
  
  
  METHODS
  BAER was studied at repetition rates 11-91/sec of clicks in 165 normal neonates and children of various ages and 29 young adults.
  
  
  RESULTS
  BAER wave latencies and inter-peak intervals increased linearly with increasing click rate at all ages. The younger was the age, the greater were BAER click rate-dependent changes. At 9 months and younger, the slopes of latency- and interval-rate functions were all significantly greater than in the adults (all p < 0.01). The slopes of wave I latency- and I-III interval-rate functions at 1-2 years and older were similar to those in adults. The slopes of wave III and V latency-rate functions and I-V and III-V interval-rate function at 3-4 years and older did not differ significantly from those in adults.
  
  
  CONCLUSIONS
  BAER is affected by stimulus rate more in younger children than in the older. Adult-like rate-dependent changes are reached at 1-2 years for wave I latency and I-III interval, and 3-4 years for wave III and V latencies and I-V and III-V intervals. Our BAER data at different click rates provide normal references for subjects of various ages.
authors.affiliation: Department of Paediatrics, Children's Hospital, Fudan University, Shanghai, China. zedong.jiang@paediatrics.ox.ac.uk
authors.forename: Ze Dong
authors.initials: ZD
authors.lastname: Jiang
authors.forename: Yun Ya
authors.initials: YY
authors.lastname: Wu
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Wilkinson
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000367:Age Factors; D000375:Aging / Q000502:physiology*; D002648:Child; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values; D012044:Regression Analysis; D055815:Young Adult