title: [Problems of experimental simulation of hypo- and hyperthyroidism].
abstract: This paper reviews main conventional and new experimental models of hypo- and hyperthyroidism. The authors propose classification of methods (physical, chemical, and biological) for modulation of thyroid activity and criteria for life-time and postmortem diagnosis of hypo- and hyperthyroidism. New approaches to simulation of diffuse toxic goiter in animals are considered, advantages and limitations of different models are compared.
authors.forename: N V
authors.initials: NV
authors.lastname: Iaglova
authors.forename: V V
authors.initials: VV
authors.lastname: Iaglov
authors.forename: T T
authors.initials: TT
authors.lastname: Berezov
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006980:Hyperthyroidism / Q000209:etiology*; D007037:Hypothyroidism / Q000209:etiology*; D012107:Research Design