title: Analysis of free flap viability based on recipient vein selection.
abstract: BACKGROUND
  Venous anastomotic failure is the primary reason for microvascular free tissue transfer failure. Donor and recipient veins can be oriented in the same longitudinal axis (end-to-end anastomosis), or the donor vein can be anastomosed to the internal jugular vein in an end-to-side configuration. No consensus on the optimal anastomosis configuration exists. We sought to evaluate whether type of venous anastomosis impacts flap survival rate.
  
  
  METHODS
  Data were collected on all patients undergoing microvascular free flap reconstruction of head and neck defects at the University of Washington between August 1993 and April 2007. Flaps with a single venous anastomosis were analyzed. Flaps were stratified into those with end-to-end and end-to-side anastomoses. Survival rates were compared between groups using bivariate and multivariate techniques.
  
  
  RESULTS
  Inclusion criteria were met by 786 free flaps; 87% performed in an end-to-end and 13% in an end-to-side configuration. Flap re-exploration and failure rate were 4.3% and 1.1%, respectively. In multivariate analysis, there was no difference in odds of flap re-exploration (OR .70, 95% CI .23-2.18) or flap failure whether or not an end-to-end or end-to-side anastomosis was performed (OR 2.09, 95% CI .38-11.5).
  
  
  CONCLUSIONS
  In this large cohort of patients, we found no difference in the odds of flap re-exploration or failure based on venous anastomotic configuration. Reconstructive surgeons should have both anastomotic techniques in their repertoire to optimize the success of every flap.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, University of Washington, Seattle, Washington, USA.
authors.forename: David O
authors.initials: DO
authors.lastname: Francis
authors.forename: Ryan E
authors.initials: RE
authors.lastname: Stern
authors.forename: Daniel
authors.initials: D
authors.lastname: Zeitler
authors.forename: Mark
authors.initials: M
authors.lastname: Izzard
authors.forename: Neal D
authors.initials: ND
authors.lastname: Futran
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000379:methods; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery* / Q000628:therapy; D006801:Humans; D007601:Jugular Veins / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013524:Surgical Flaps; D014022:Tissue Survival; D055815:Young Adult