Osteoarthritis of the ankle: bridging concepts in basic science with clinical care.
Trends in science are beginning to suggest that cartilage degeneration may be related to a chronic imbalance in extracellular matrix metabolism. In cartilage, a combination of biomechanical, biochemical, and matrix-related signaling pathways regulates the equilibrium between cartilage anabolism and catabolism. A potential limitation of many current treatments of osteoarthritis is that they may not comprehensively restore regulation of a balance between cartilage anabolism and catabolism.
Joseph
Robert Michael
RM
Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, 305 Oakwood Avenue, Dayton, OH 45409, USA. footbiochemistry@hotmail.com
D000367:Age Factors; D001696:Biomechanical Phenomena; D035843:Biomedical Research; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology*; D019902:Chondrocytes / Q000378:metabolism*; D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D006801:Humans; D007719:Knee Joint; D008297:Male; D010003:Osteoarthritis / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D015398:Signal Transduction; D013314:Stress, Mechanical