CLC-7: a potential therapeutic target for the treatment of osteoporosis and neurodegeneration.
CLC-7 is a member of the voltage-gated chloride channels family. It resides mainly in the late endosomes, lysosomes and the ruffled membrane of osteoclasts. Mice deficient in the ubiquitously expressed ClC-7 Cl(-) channel show severe osteopetrosis and retinal degeneration. In the present review, some of the known features of CLC-7 such as structure, function and its roles in physiological or pathophysiological processes are highlighted.
Zhao
Qingxiao
Q
College of Chemical Engineering, Northeast Dianli University, Jilin, PR China. Xiaozhaoqingxiao@163.com
Wei
Qun
Q
He
Aimin
A
Jia
Ruokun
R
Xiao
Yongtao
Y
D000818:Animals; D018118:Chloride Channels / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D010022:Osteopetrosis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D012162:Retinal Degeneration / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism
C097540:CLCN7 protein, human; D018118:Chloride Channels