Donepezil (aricept) as a treatment for anorexia nervosa: a very feasible therapeutic possibility.
Anorexia nervosa is a serious, multifactorial disease, characterized by psychiatric and neurological disturbances, which would appear to be similar to the manifestations of dementia. Patients with anorexia nervosa present compromised affectivity, characterized by hypomanic, manic and depressive symptoms, and their cholinergic system is altered with a decrease in the release of acetylcholine. Donepezil is a drug that been proven to be effective in the treatment of dementia, including Alzheimer's; it has been used for affective disorders and its mechanism of action is to inhibit the acetylcholinesterase enzyme to increase acetylcholine. Therefore, donepezil could be effective in treating anorexia nervosa.
Halabe Bucay
Alberto
A
Research Center Halabe and Darwic, 22 de Diciembre num 1, Nuacalpan 53910, Mexico. doctorhalabe@hotmail.com
D000818:Animals; D000856:Anorexia Nervosa / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D000077265:Donepezil; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D016896:Treatment Outcome
D007189:Indans; D010880:Piperidines; D000077265:Donepezil