[Bone fracture and the healing mechanisms. Fibroblast growth factor-2 and fracture healing].
Fibroblast growth factor-2 (FGF-2) is a crucial regulator of bone metabolism with strong stimulatory effects on both bone formation and resorption. The potent bone anabolic action of FGF-2 has been demonstrated in several animal models including rodents and non-human primates. Our recent clinical trial has revealed that recombinant human (rh) FGF-2 in gelatin hydrogel dose dependently accelerated bone union of a surgical osteotomy with an excellent safety profile, suggesting the efficacy of this agent for bone repair.
Kawaguchi
Hiroshi
H
Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo.
D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism; D002986:Clinical Trials as Topic; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage* / Q000494:pharmacology / Q000502:physiology*; D017102:Fracture Healing / Q000235:genetics* / Q000502:physiology*; D005780:Gelatin; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010012:Osteogenesis / Q000187:drug effects; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013268:Stimulation, Chemical
D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D005780:Gelatin