Cytogenetic evaluation for genotoxicity of bisphenol-A in bone marrow cells of Swiss albino mice.
Bisphenol-A (BP-A) is a xenobiotic estrogenic compound used in a wide range of consumer products. BP-A was tested for its genotoxicity by employing three cytogenetic assays, viz., chromosomal aberration test, micronucleus assay and test for c-mitotic effects in Swiss albino mice. Studies were carried out for three doses, 10, 50 and 100 mg/kg in single oral exposure and 10 mg/kg in repeated oral exposure (for 5 days). It is evident from the present investigation that although BP-A failed to induce conventional chromosomal aberrations and micronuclei, its genotoxic potential was manifested in the form of achromatic lesion and c-mitotic effects in the bone marrow cells. It can also be speculated from the results that the threshold concentration of BP-A required for the formation of MN is much higher than that for the induction of c-mitotic effects.
Naik
Prashantha
P
Department of Post-Graduate Studies and Research in Biosciences, Mangalore University, Mangalagangothri 574 199, D.K., India.
Vijayalaxmi
K K
KK
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D001559:Benzhydryl Compounds; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism; D002273:Carcinogens / Q000633:toxicity; D002869:Chromosome Aberrations / Q000139:chemically induced*; D003582:Cytogenetics; D004249:DNA Damage / Q000187:drug effects / Q000235:genetics; D005260:Female; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity; D010636:Phenols / Q000633:toxicity*; D000098826:Bisphenol A Compounds
D018906:Antineoplastic Agents, Alkylating; D001559:Benzhydryl Compounds; D002273:Carcinogens; D009153:Mutagens; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds