Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides.
This paper describes the synthesis, antiplatelet and theoretical evaluations of 10 N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides (2a-j). These compounds were synthesized, characterized and screened for their in vitro antiplatelet profile against human platelet aggregation using arachidonic acid, adrenaline and ADP as agonists. Among NAH derivatives 2a-j, the compounds 2a, 2c, 2e, 2g and 2h were the most promising molecules with significant antiplatelet activity.
Jordão
Alessandro K
AK
Universidade Federal Fluminense, Departamento de Química Orgânica, Outeiro de São João Batista, s/n degrees , Niterói, 24020-141 Rio de Janeiro, Brazil.
Ferreira
Vitor F
VF
Lima
Emerson S
ES
de Souza
Maria C B V
MC
Carlos
Eduardo C L
EC
Castro
Helena C
HC
Geraldo
Reinaldo B
RB
Rodrigues
Carlos R
CR
Almeida
Maria C B
MC
Cunha
Anna C
AC
D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D006834:Hydrazines; D010975:Platelet Aggregation Inhibitors; D014230:Triazoles