title: Dietary modulation of ghrelin and leptin and gorging behavior after weight loss in the obese Zucker rat.
abstract: In this study, we measured ghrelin and leptin in obese Zucker rats after weight loss induced by calorie restriction using either a low-fat (LF) or high-energy palatable (HEPa) diet. After weight loss, the animals were refed lab chow and offered one hour-palatable test meals on the second and fifteenth days of refeeding. Both LF and HEPa rats lost 10% of their initial body weight (P<0.0001). Plasma ghrelin increased with calorie restriction in both groups (P<0.002) with a tendency to a higher increase in the HEPa group while plasma leptin decreased only in the LF group (P<0.01). Both groups ate the same quantity of chow during refeeding and both groups gorged on palatable diet during test meals at a very high constant intensity in HEPa rats. After one week of refeeding, ghrelin levels remained elevated in HEPa rats (+33.2%; P<0.001) while returning to baseline in LF rats. Plasma leptin remained low in LF rats. We conclude that weight loss on a palatable diet is possible if total energy intake is controlled. After stopping restriction, when a palatable diet is available, observed gorging might be dependent on specific ghrelin and leptin changes.
authors.affiliation: INSERM, U954, Nutrition, Génétique et Exposition aux Risques Environnementaux, Faculté de Médecine, Vandoeuvre Cedex, France. bernard.beck@nancy.inserm.fr
authors.forename: B
authors.initials: B
authors.lastname: Beck
authors.forename: S
authors.initials: S
authors.lastname: Richy
mesh_terms: D050154:Adiposity / Q000502:physiology; D000818:Animals; D001835:Body Weight / Q000502:physiology; D031204:Caloric Restriction; D004032:Diet; D002149:Energy Intake / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D054439:Ghrelin / Q000097:blood*; D006963:Hyperphagia / Q000097:blood / Q000473:pathology / Q000503:physiopathology; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood*; D051381:Rats; D011924:Rats, Zucker; D015431:Weight Loss / Q000502:physiology*
chemical_list: D054439:Ghrelin; D020738:Leptin