title: Mutation in bovine beta-carotene oxygenase 2 affects milk color.
abstract: beta-Carotene biochemistry is a fundamental process in mammalian biology. Aberrations either through malnutrition or potentially through genetic variation may lead to vitamin A deficiency, which is a substantial public health burden. In addition, understanding the genetic regulation of this process may enable bovine improvement. While many bovine QTL have been reported, few of the causative genes and mutations have been identified. We discovered a QTL for milk beta-carotene and subsequently identified a premature stop codon in bovine beta-carotene oxygenase 2 (BCO2), which also affects serum beta-carotene content. The BCO2 enzyme is thereby identified as a key regulator of beta-carotene metabolism.
authors.affiliation: ViaLactia Biosciences, Newmarket, Auckland, New Zealand.
authors.forename: S D
authors.initials: SD
authors.lastname: Berry
authors.forename: S R
authors.initials: SR
authors.lastname: Davis
authors.forename: E M
authors.initials: EM
authors.lastname: Beattie
authors.forename: N L
authors.initials: NL
authors.lastname: Thomas
authors.forename: A K
authors.initials: AK
authors.lastname: Burrett
authors.forename: H E
authors.initials: HE
authors.lastname: Ward
authors.forename: A M
authors.initials: AM
authors.lastname: Stanfield
authors.forename: M
authors.initials: M
authors.lastname: Biswas
authors.forename: A E
authors.initials: AE
authors.lastname: Ankersmit-Udy
authors.forename: P E
authors.initials: PE
authors.lastname: Oxley
authors.forename: J L
authors.initials: JL
authors.lastname: Barnett
authors.forename: J F
authors.initials: JF
authors.lastname: Pearson
authors.forename: Y
authors.initials: Y
authors.lastname: van der Does
authors.forename: A H K
authors.initials: AH
authors.lastname: Macgibbon
authors.forename: R J
authors.initials: RJ
authors.lastname: Spelman
authors.forename: K
authors.initials: K
authors.lastname: Lehnert
authors.forename: R G
authors.initials: RG
authors.lastname: Snell
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D033481:Chromosomes, Mammalian / Q000235:genetics; D003116:Color; D003433:Crosses, Genetic; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D008297:Male; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D009154:Mutation; D010105:Oxygenases / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci / Q000235:genetics; D019207:beta Carotene / Q000097:blood / Q000378:metabolism
chemical_list: D019207:beta Carotene; D010105:Oxygenases; C093259:beta-carotene ketolase