Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer.
Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.
Nilsson
J
J
Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden. j.nilsson@vumc.nl
Skog
J
J
Nordstrand
A
A
Baranov
V
V
Mincheva-Nilsson
L
L
Breakefield
X O
XO
Widmark
A
A
D000951:Antigens, Neoplasm / Q000032:analysis / Q000235:genetics / Q000652:urine; D014408:Biomarkers, Tumor / Q000235:genetics / Q000652:urine*; D055354:Exosomes / Q000235:genetics / Q000473:pathology*; D006801:Humans; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000032:analysis / Q000235:genetics / Q000652:urine; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000652:urine*; D012333:RNA, Messenger / Q000032:analysis; D016482:Urinalysis / Q000379:methods
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger; C515553:TMPRSS2-ERG fusion protein, human; C479341:prostate cancer antigen 3, human