Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages.
Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN. All patients with gain of REL were unmutated for IGHV (p=0.03). Gain of MYCN was associated with increased mRNA expression (p=0.005), suggesting a pathogenic role for MYCN. Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.
Chapiro
Elise
E
Service d'hématologie biologique, CHU Pitié-Salpêtrière, Université Paris 6, France.
Leporrier
Nathalie
N
Radford-Weiss
Isabelle
I
Bastard
Christian
C
Mossafa
Hossein
H
Leroux
Dominique
D
Tigaud
Isabelle
I
De Braekeleer
Marc
M
Terré
Christine
C
Brizard
Françoise
F
Callet-Bauchu
Evelyne
E
Struski
Stéphanie
S
Veronese
Lauren
L
Fert-Ferrer
Sandra
S
Taviaux
Sylvie
S
Lesty
Claude
C
Davi
Frédéric
F
Merle-Béral
Hélène
H
Bernard
Olivier A
OA
Sutton
Laurent
L
Raynaud
Sophie D
SD
Nguyen-Khac
Florence
F
D002869:Chromosome Aberrations; D002889:Chromosomes, Human, Pair 2; D018628:Gene Dosage; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*