Serum amyloid a protein and C-reactive protein in normal pregnancy and preeclampsia.
OBJECTIVE
To study plasma levels of serum amyloid A protein and C-reactive protein in pregnant women with and without preeclampsia and non-pregnant women. Plasma levels of haptoglobin, orosomucoid and ceruloplasmin were also analyzed.


METHODS
The study included 295 women with uncomplicated pregnancies, 57 women diagnosed with preeclampsia, and 58 healthy non-pregnant women. Plasma concentrations of acute phase proteins were analyzed by particle-enhanced immunoassays. Non-parametric Kruskal-Wallis and Mann-Whitney U tests were used to test differences between the groups.


RESULTS
Plasma levels of C-reactive protein and ceruloplasmin were increased in pregnant women with and without preeclampsia compared to non-pregnant women. Plasma levels of serum amyloid A protein and C-reactive protein were not elevated in women with preeclampsia compared to women with normal pregnancy.


CONCLUSIONS
The description of preeclampsia as a systemic inflammatory state was not reflected in the plasma levels of serum amyloid A protein and C-reactive protein.
Kristensen
K
K
Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden.
Wide-Swensson
D
D
Lindstrom
V
V
Schmidt
C
C
Grubb
A
A
Strevens
H
H
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007118:Immunoassay; D009961:Orosomucoid / Q000032:analysis; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D000685:Serum Amyloid A Protein / Q000032:analysis*
D006242:Haptoglobins; D009961:Orosomucoid; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein; D002570:Ceruloplasmin