title: Increased circulating Dickkopf-1 in Paget's disease of bone.
abstract: Dickkopf-1 (Dkk-1) is a secreted inhibitor of Wnt signaling which in adults regulates bone turnover. Dkk-1 over-production is implicated in osteolytic disease where it inhibits bone formation and stimulates bone breakdown. Recently it was reported that osteoblastic cells from Paget's disease of bone (PDB) over-expressed Dkk-1.
  
  
  OBJECTIVE
  To see if increased Dkk-1 was detected in serum from patients with PDB.
  
  
  RESULTS
  Dkk-1 and total serum alkaline phosphatase activity (tsAP) were significantly elevated in sera from PDB patients. Patients with polyostotic PDB had significantly higher levels of tsAP but not Dkk-1, than monostotic patients. TsAP but not Dkk-1, was significantly lower in sera from bisphosphonate treated versus untreated PDB patients. Dkk-1 and tsAP were not significantly correlated.
  
  
  CONCLUSIONS
  Dkk-1 may be a useful biomarker of PDB and we speculate that Dkk-1 may play a central role in the etiology of PDB.
authors.affiliation: Charles Salt Centre for Human Metabolism, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Oswestry, Shropshire, SY10 7AG, UK. michael.marshall@rjah.nhs.uk
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Marshall
authors.forename: Sally F
authors.initials: SF
authors.lastname: Evans
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Sharp
authors.forename: Diane E
authors.initials: DE
authors.lastname: Powell
authors.forename: Helen S
authors.initials: HS
authors.lastname: McCarthy
authors.forename: Michael W J
authors.initials: MW
authors.lastname: Davie
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000097:blood* / Q000201:enzymology
chemical_list: C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000469:Alkaline Phosphatase