Modern concepts in the diagnosis and treatment of vitamin D deficiency and its clinical consequences.
It is the purpose of this comprehensive report to outline a revolutionary strategy to prevent vitamin D deficiency in our nation. Vitamin D is a unique vitamin. Its metabolic product, calcitriol, is a profound secosteroid hormone that has impact on over 1000 genes in the human body. Recent clinical research has implicated vitamin D deficiency as a major factor in the etiology of rickets, a wide variety of cancers, as well as hypertension, stroke, heart attack, diabetes, bone fractures, periodontal disease, and even multiple sclerosis. There are two forms of vitamin D utilized in the human body: D2 and D3. Measurement of 25(OH)D is the most reliable method of detecting vitamin D deficiency. Several methods, including high-performance liquid chromatography (HPLC), chemoluminescence, and radioimmunoassay (RIA), have been developed for the measurement of total 25(OH)D levels. Prevention and treatment of vitamin D deficiency is accomplished by regulated sun exposure as well as vitamin D, supplementation. This information describing our plan to prevent vitamin D deficiency in the patients and employees of Legacy Health System is a landmark accomplishment that should be replicated in every healthcare setting in our country to prevent vitamin D deficiency.
Edlich
Richard
R
University of Virginia Health System, Charlottesvill, VA, USA. richardedlich@gmail.com
Fisher
Allyson L
AL
Chase
Margot E
ME
Brock
Carroll M
CM
Gubler
K
K
Long
William B
WB
D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D019587:Dietary Supplements; D006801:Humans; D013472:Sunlight; D053719:Tandem Mass Spectrometry; D014193:Trauma Centers; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000175:diagnosis* / Q000517:prevention & control*
D014807:Vitamin D