Axon growth and guidance: receptor regulation and signal transduction.
The development of precise connectivity patterns during the establishment of the nervous system depends on the regulated action of diverse, conserved families of guidance cues and their neuronal receptors. Determining how these signaling pathways function to regulate axon growth and guidance is fundamentally important to understanding wiring specificity in the nervous system and will undoubtedly shed light on many neural developmental disorders. Considerable progress has been made in defining the mechanisms that regulate the correct spatial and temporal distribution of guidance receptors and how these receptors in turn signal to the growth cone cytoskeleton to control steering decisions. This review focuses on recent advances in our understanding of the mechanisms mediating growth cone guidance with a particular emphasis on the control of guidance receptor regulation and signaling.
O'Donnell
Michael
M
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. odonnel2@mail.med.upenn.edu
Chance
Rebecca K
RK
Bashaw
Greg J
GJ
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D003463:Cues; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism*; D009420:Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D009434:Neural Pathways / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D009414:Nerve Growth Factors; D017475:Receptors, Nerve Growth Factor