Reference values for continuous glucose monitoring in Chinese subjects.
OBJECTIVE
The widespread clinical application of continuous glucose monitoring (CGM) is limited by the lack of generally accepted reference values. This multicenter study aims to establish preliminary normal reference values for CGM parameters in a sample of healthy Chinese subjects.


METHODS
A total of 434 healthy individuals with normal glucose regulation completed a 3-day period of glucose monitoring using a CGM system. The 24-h mean blood glucose (24-h MBG) and the percentage of time that subjects' blood glucose levels were >or=140 mg/dl (PT140) and <or=70 mg/dl (PT70) within 24 h were analyzed.


RESULTS
There was excellent compliance of finger stick blood glucose values with CGM measurements for subjects. Among the 434 subjects, the daily blood glucose varied from 76.9 +/- 11.3 to 144.2 +/- 23.2 mg/dl. The 24-h MBG, PT140, and PT70 were 104 +/- 10 mg/dl, 4.1 +/- 5.8%, and 2.4 +/- 5.3%, respectively. As for these parameters, no significant differences were found between men and women. The 95th percentile values were adopted as the upper limits of CGM parameters, which revealed 119 mg/dl (6.6 mmol/l) for 24-h MBG, 17.1% for PT140, and 11.7% for PT70.


CONCLUSIONS
We recommend a 24-h MBG value <119 mg/dl, PT140 <17% (4 h), and PT70 <12% (3 h) as normal ranges for the Chinese population.
Zhou
Jian
J
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China.
Li
Hong
H
Ran
Xingwu
X
Yang
Wenying
W
Li
Qiang
Q
Peng
Yongde
Y
Li
Yanbing
Y
Gao
Xin
X
Luan
Xiaojun
X
Wang
Weiqing
W
Jia
Weiping
W
D000328:Adult; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D001794:Blood Pressure; D002681:China; D002784:Cholesterol / Q000097:blood; D004435:Eating / Q000502:physiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000379:methods*; D010349:Patient Compliance; D012016:Reference Values
D001786:Blood Glucose; D002784:Cholesterol