[Acute pancreatitis induced by cyclosporine a following allogeneic hematopoietic stem cell transplant].
Pancreatitis has not been reported in allogeneic stem cell transplant (allo-SCT) recipients with cyclosporine in China. This article presented a case of acute pancreatitis in a 49-year-old patient with AML-M2a who received allogeneic stem cell transplant from her HLA identical sister. The preparative regimen consisted of busulfan and cyclophosphamide. The cyclosporine A, short-term methotrexate and antilymphocyte globulin (ATG), were used to prevent the graft-versus-host disease (GVHD). Clinical and laboratory signs of acute pancreatitis were found in the patient on day 20 post-transplant. A diagnosis of acute pancreatitis was made although the pancreas was apparently normal at abdominal contrast-enhanced tomography and ultrasonography. She recovered with supportive care and reduction of cyclosporine dose. In conclusion, cyclosporine is the probable cause of pancreatitis in this patient.
Guo
Rong
R
Department of Hematology, Guangdong Provincial People Hospital, Guangzhou 510080, Guangdong Province, China. gh7311@yahoo.com.cn
DU
Xin
X
Weng
Jian-Yu
JY
Deng
Cheng-Xin
CX
Wu
Sui-Jing
SJ
Luo
Cheng-Wei
CW
D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000139:chemically induced*; D011183:Postoperative Complications / Q000139:chemically induced*
D016572:Cyclosporine