Evolution of protein modularity.
Proteins in their evolution appear to follow several discrete stages, which is reflected in their modular organization. The sequences of the protein modules are highly variable while their functions and structures are rather conserved. The relatedness of the variable sequences is well represented by the networks in natural protein sequence space that also suggests evolutionary connections.
Trifonov
Edward N
EN
Genome Diversity Center, Institute of Evolution, University of Haifa, Haifa 31905, Israel. trifonov@research.haifa.ac.il
Frenkel
Zakharia M
ZM
D000595:Amino Acid Sequence; D019143:Evolution, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
D011506:Proteins