Alzheimer's disease and atherosclerosis: passers-by or brothers?
There seems to be little relationship between Alzheimer's disease and atherosclerotic disease for quite a long time. But current evidence from epidemiological, pathological, and clinical studies indicate an association of them both. We speculate that Alzheimer's disease and atherosclerosis are brothers but not passers-by, in molecule, especially in the light of interaction between reticulon 3(RTN3) and reticulon 4(RTN4B).
Xing
Yu
Y
Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
Zhao
Shuiping
S
Xiang
Rong
R
D000544:Alzheimer Disease / Q000378:metabolism; D050197:Atherosclerosis / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D009185:Myelin Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D000070798:Nogo Proteins; D011485:Protein Binding
D002352:Carrier Proteins; D008565:Membrane Proteins; D009185:Myelin Proteins; D009419:Nerve Tissue Proteins; D000070798:Nogo Proteins; C476198:RTN3 protein, human; C000603199:RTN4 protein, human