[Application of laparoscopic surgery following neoadjuvant chemoradiotherapy for mid-low rectal cancer].
OBJECTIVE
To evaluate the safety and feasibility of laparoscopic surgery following neoadjuvant chemoradiotherapy (CRT) for mid-low rectal cancer.


METHODS
A retrospective analysis was conducted among 24 patients with mid-low rectal cancer who received laparoscopic total mesorectal excision (TME) after neoadjuvant CRT. Another 24 patients with mid-low rectal cancer were randomly selected form those undergoing primary laparoscopic TME to serve as the control group. The clinical data and surgical data of the two groups of patients were collected and analyzed comparatively.


RESULTS
TME after CRT resulted in significantly lower lymph node yield compared with the control group (7.08-/+6.5 vs 12.5-/+4.1, P<0.05). The two groups were comparable in the operative time, intraoperative blood loss, intestinal function recovery, positive surgical margins, rate of conversion to open surgery, and occurrence of intra- and postoperative complications.


CONCLUSIONS
Laparoscopic surgery of mid-low rectal cancer after neoadjuvant CRT can be safe and feasible and produce surgical effects comparable to exclusive laparoscopic surgery.
Xiong
Hui
H
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. 199xh@163.com
Yu
Jiang
J
Zhang
Ce
C
Wang
Ya-nan
YN
Hu
Yan-feng
YF
Li
Guo-xin
GX
D016022:Case-Control Studies; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery* / Q000628:therapy*; D012189:Retrospective Studies; D012449:Safety; D016896:Treatment Outcome