title: Short-course radiotherapy, with elective delay prior to surgery, in patients with unresectable rectal cancer who have poor performance status or significant co-morbidity.
abstract: OBJECTIVE
  Standard treatment for rectal cancer which threatens the expected plane of resection on MRI imaging is long-course, pre-operative chemoradiotherapy (1.8-2Gy, 25-28 fractions). Not all patients are suitable for this because of age, poor performance status or co-morbidities. We describe our experience of short-course (5x5Gy) pre-operative radiotherapy with planned, delayed surgery (SCPRT-delay) in this patient group.
  
  
  METHODS
  Between April 2001 and October 2007, 43 patients were selected for SCPRT-delay. The clinical records were retrospectively evaluated.
  
  
  RESULTS
  Median age was 82 (range 58-87). Forty-one patients had radiotherapy of which 26 (61%) were subsequently able to have surgery. Of these, R0, R1 and R2 resections were performed in 22, 2 and 2 patients, respectively. Treatment was well tolerated, although two patients required hospital admission for management of diarrhoea and one developed significant late small bowel toxicity, attributable to radiotherapy. In those undergoing R0 or R1 resection there have been no local recurrences (median follow-up 18 months). Median survival for the whole group was 23 months, although this was 44 months in those undergoing surgery.
  
  
  CONCLUSIONS
  SCPRT-delay appears to be a useful alternative to long-course pre-operative chemoradiotherapy in this high-risk group of patients.
authors.affiliation: St. James's Institute of Oncology, St. James's University Hospital, Beckett Street, Leeds, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Hatfield
authors.forename: Mohan
authors.initials: M
authors.lastname: Hingorani
authors.forename: Ganesh
authors.initials: G
authors.lastname: Radhakrishna
authors.forename: Rachel
authors.initials: R
authors.lastname: Cooper
authors.forename: Alan
authors.initials: A
authors.lastname: Melcher
authors.forename: Adrian
authors.initials: A
authors.lastname: Crellin
authors.forename: Michelle
authors.initials: M
authors.lastname: Kwok-Williams
authors.forename: David
authors.initials: D
authors.lastname: Sebag-Montefiore
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D013997:Time Factors