Viral avoidance and exploitation of the ubiquitin system.
The versatility of ubiquitin in regulating protein function and cell behaviour through post-translational protein modification makes it a particularly attractive target for viruses. Here we review how viruses manipulate the ubiquitin system to favour their propagation by redirecting cellular ubiquitin enzymes or encoding their own ubiquitin components to enable replication, egress and immune evasion. These studies not only reveal the many cellular processes requiring ubiquitin but also illustrate how viruses usurp their host cells.
Randow
Felix
F
Division of Protein and Nucleic Acid Chemistry, Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. randow@mrc-lmb.cam.ac.uk
Lehner
Paul J
PJ
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D010450:Endopeptidases / Q000502:physiology; D005814:Genes, Viral / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D025801:Ubiquitin / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D025801:Ubiquitin; D014764:Viral Proteins; D044767:Ubiquitin-Protein Ligases; D010450:Endopeptidases