title: Preoperative plasma adiponectin level is a risk factor for postoperative infection following colorectal cancer surgery.
abstract: BACKGROUND
  Adiponectin is produced exclusively by adipose tissues. It is associated with visceral adiposity and various metabolic disorders, and acts as an anti-inflammatory protein that inhibits nuclear factor-kappaB activation. The purpose of this study is to clarify the association between the preoperative plasma adiponectin levels and the development of postoperative infection following colorectal cancer surgery.
  
  
  METHODS
  Peripheral blood samples were collected from 41 colorectal cancer patients before surgery and on postoperative days (PODs) 1, 3, 5, and 7. Plasma adiponectin, leptin, and serum C-reactive protein (CRP) levels were measured and the white blood cells (WBCs) were counted. Subcutaneous and visceral fat volumes were quantified by preoperative CT scans. The patients were divided into a group with postoperative infections and an uninfected group.
  
  
  RESULTS
  In both groups, the postoperative plasma adiponectin levels decreased transiently and then gradually recovered. However, the infected group had significantly lower adiponectin levels throughout the perioperative period than the uninfected group. Logistic regression analysis revealed that preoperative adiponectin level was an independent risk factor for postoperative infection.
  
  
  CONCLUSIONS
  Preoperative adiponectin levels may be useful for anticipating the development of postoperative infection following colorectal cancer surgery.
authors.affiliation: Department of Surgery, Nippon Medical School Tama-Nagayama Hospital, Tama, Tokyo, Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Matsuda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsutani
authors.forename: Koji
authors.initials: K
authors.lastname: Sasajima
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Furukawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Tajiri
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kogo
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D001424:Bacterial Infections / Q000097:blood* / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D015999:Multivariate Analysis; D011183:Postoperative Complications; D011237:Predictive Value of Tests; D057234:Preoperative Period; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D002097:C-Reactive Protein