[Progress of study on relationship between Mcl-1 gene and hematologic malignancies - review].
Mcl-1 (myeloid cell leukemia-1) is a member of Bcl-2 (B cell leukemia-2) family, which may play an important role in cell apoptosis regulation, occurrence and development of tumors. This paper reviews advance of studies on the function of the mcl-1 gene and MCL-1 protein, the signal transduction pathways (JAK/STAT, MAPK, PI-3K) regulating the expression of mcl-1 gene, and the relationship between mcl-1 gene and hematologic malignancies.
Li
Zhi-Hui
ZH
Department of Hematology, Yunnan Second People Hospital, Kunming 650021, Yunnan Province, China.
Li
Hui-Min
HM
D017209:Apoptosis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D009101:Multiple Myeloma / Q000235:genetics; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D015398:Signal Transduction
D064549:Myeloid Cell Leukemia Sequence 1 Protein; D019253:Proto-Oncogene Proteins c-bcl-2