title: Allometric scaling of chemical restraint associated with inhalant anesthesia in giant anteaters.
abstract: This study describes the use of allometric scaling in five giant anteaters (Myrmecophaga tridactyla) submitted for osteosynthesis, gastrostomy, or treatment of burns. Chemical restraint was performed by allometric scaling using the dog as a reference; acepromazine (0.06 mg/kg), diazepam (0.3 mg/kg), ketamine (8.8 mg/kg), and buprenorphine (5.9 microg/kg) were combined, and the animals were maintained under isoflurane anesthesia. Heart rate, respiratory rate, hemoglobin oxygen saturation, temperature, and anesthetic depth were measured. Postoperative treatment consisted of ketoprofen, buprenorphine, and ceftiofur. Anesthetic induction was obtained in 10-15 min, achieving muscle relaxation and absence of excitement. Physiologic parameters were stable during the procedures, and postoperative treatment was effective. Allometric scaling was effective for chemical restraint and postoperative treatment.
authors.affiliation: Department of Small Animal Medicine, Federal University of Santa Maria, Santa Maria, RS, 97105-900 Brazil. carregaro@smail.ufsm.br
authors.forename: Adriano Bonfim
authors.initials: AB
authors.lastname: Carregaro
authors.forename: Patrícia Molina
authors.initials: PM
authors.lastname: Gerardi
authors.forename: Daniel Kan
authors.initials: DK
authors.lastname: Honsho
mesh_terms: D000075:Acepromazine / Q000008:administration & dosage; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation / Q000379:methods / Q000662:veterinary*; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D000818:Animals; D000835:Animals, Wild; D001835:Body Weight / Q000502:physiology*; D002047:Buprenorphine / Q000008:administration & dosage; D003975:Diazepam / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007649:Ketamine / Q000008:administration & dosage; D008433:Mathematics; D012119:Respiration / Q000187:drug effects; D014894:Weights and Measures; D004490:Xenarthra / Q000502:physiology* / Q000601:surgery
chemical_list: D019162:Anesthetics, Combined; D002047:Buprenorphine; D000075:Acepromazine; D007649:Ketamine; D003975:Diazepam