AMPK in the brain: its roles in energy balance and neuroprotection.
Adenosine monophosphate-activated protein kinase (AMPK) senses metabolic stress and integrates diverse physiological signals to restore energy balance. Multiple functions are indicated for AMPK in the CNS. While all neurons sense their own energy status, some integrate neuro-humoral signals to assess organismal energy balance. A variety of disease states may involve AMPK, so determining the underlying mechanisms is important. We review the impact of altered AMPK activity under physiological (hunger, satiety) and pathophysiological (stroke) conditions, as well as therapeutic manipulations of AMPK that may improve energy balance.
Ronnett
Gabriele V
GV
Department of Neuroscience, The Center for Metabolism and Obesity Research (CMOR), The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. gronnett@jhmi.edu
Ramamurthy
Santosh
S
Kleman
Amy M
AM
Landree
Leslie E
LE
Aja
Susan
S
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D004789:Enzyme Activation / Q000502:physiology; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology
D017868:Cyclic AMP-Dependent Protein Kinases