[New strategy to promote adult spinal cord regeneration: enhance adult neurons' intrinsic growth capability].
Injured adult spinal cord neurons are usually unable to regenerate their axons due to the inhibitory environment and low intrinsic regenerative capability. One of the main strategies to promote spinal cord regeneration is blocking and/or neutralizing the inhibitory factors or their common inhibitory signal pathway. However, overcoming inhibition alone is insufficient to cause extensive regeneration when neurons' intrinsic growth state has not been activated. Therefore, it becomes one of the most interested targets for promoting spinal cord regeneration that how to enhance adult neurons' intrinsic growth capability, such as elevating adult neuron cAMP/PKA level, blocking Rho/ROCK pathway, modulating transcriptional factors etc., such that they no longer response to inhibitory environment. In this paper we will review the current research findings and recent progresses in this field.
Yang
Ping
P
Department of Neurobiology, Third Military Medical University, Chongqing 400038, China.
D000818:Animals; D006801:Humans; D009416:Nerve Regeneration; D055495:Neurogenesis / Q000502:physiology; D009474:Neurons / Q000166:cytology; D058630:Spinal Cord Regeneration / Q000502:physiology