title: The preventive effect of adjuvant-free administration of TNF-PADRE autovaccine on collagen-II-induced rheumatoid arthritis in mice.
abstract: Adjuvants are necessary to elicit high titers of antibodies in vaccine-immunization procedures. We previously developed a mouse tumor necrosis factor-alpha (TNF-alpha) autovaccine (mTNF-PADRE) capable of inducing anti-TNF-alpha antibodies. In this study, we investigated the therapeutic effect of adjuvant-free administration of the autovaccine on collagen-type-II-induced rheumatoid arthritis (CIA) in mice. Our results showed that the vaccine could ameliorate the symptoms of CIA in mice. In addition, this study suggests that it is possible to control the antibody levels in mice immunized with mTNF-PADRE without adjuvant.
authors.affiliation: State Key Laboratory of Cancer Biology, Xi'an, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wan
authors.forename: Shifang
authors.initials: S
authors.lastname: Yuan
authors.forename: Xiaochang
authors.initials: X
authors.lastname: Xue
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Qin
authors.forename: Cun
authors.initials: C
authors.lastname: Zhang
authors.forename: Weihua
authors.initials: W
authors.lastname: Wang
authors.forename: Changli
authors.initials: C
authors.lastname: Jiang
authors.forename: Shouzhen
authors.initials: S
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Wenhua
authors.initials: W
authors.lastname: Zhu
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Ran
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Yingqi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000843:Ankle Joint / Q000276:immunology / Q000473:pathology; D000917:Antibody Formation / Q000276:immunology; D001169:Arthritis, Experimental / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D054991:Autovaccines / Q000008:administration & dosage* / Q000276:immunology; D024043:Collagen Type II / Q000276:immunology; D004195:Disease Models, Animal; D007719:Knee Joint / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; D054991:Autovaccines; D024043:Collagen Type II; D014409:Tumor Necrosis Factor-alpha; C523999:mTNF-PADRE