title: Synthesis, antimicrobial activity and QSAR studies of new 2,3-disubstituted-3,3a,4,5,6,7-hexahydro-2H-indazoles.
abstract: Antimicrobial activity of synthesized 2,3-disubstituted-3,3a,4,5,6,7-hexahydro-2H-indazole derivatives indicated that 3-(4-chlorophenyl)-2-(4-nitrophenylsulfonyl)-3,3a,4,5,6,7-hexahydro-2H-indazole (6) and 3-(4-fluorophenyl)-2-(4-nitrophenylsulfonyl)-3,3a,4,5,6,7-hexahydro-2H-indazole (20) were the most active compounds. Further, the results of QSAR studies indicated the importance of topological parameters (2)chi and (2)chi(v) in defining the antimicrobial activity of hexahydroindazoles.
authors.affiliation: Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, India. maninderminu@rediffmail.com
authors.forename: Maninder
authors.initials: M
authors.lastname: Minu
authors.forename: Ananda
authors.initials: A
authors.lastname: Thangadurai
authors.forename: Sharad Ramesh
authors.initials: SR
authors.lastname: Wakode
authors.forename: Shyam Sundar
authors.initials: SS
authors.lastname: Agrawal
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Narasimhan
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D021281:Quantitative Structure-Activity Relationship
chemical_list: C541971:3-(4-chlorophenyl)-2-(4-nitrophenylsulfonyl)-3,3a,4,5,6,7-hexahydro-2H-indazole; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007191:Indazoles