title: [Effect of fullerenes C60 on the amyloids of X-protein].
abstract: The inhibitory effect of hydrated fullerene C60 (HyFn) and the sodium salt of the fullerene polycarboxylic derivative C60Cl (C6H4CH2COONa)5 on the formation of amyloid fibrils by X-protein in vitro has been studied by electron microscopy. It has been shown that these compounds not only destroyed mature amyloid fibrils but also prevented the formation of new fibrils. This property of fullerenes, nanoparticles, can be used for the development of a novel medicinal nanotechnology in the therapy of amyloidoses.
authors.forename: L G
authors.initials: LG
authors.lastname: Marsagishvili
authors.forename: A G
authors.initials: AG
authors.lastname: Bobylev
authors.forename: M D
authors.initials: MD
authors.lastname: Shpagina
authors.forename: P A
authors.initials: PA
authors.lastname: Troshin
authors.forename: Z A
authors.initials: ZA
authors.lastname: Podlubnaia
mesh_terms: D000682:Amyloid / Q000737:chemistry* / Q000648:ultrastructure; D000818:Animals; D037741:Fullerenes / Q000737:chemistry*; D009124:Muscle Proteins / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011817:Rabbits
chemical_list: D000682:Amyloid; D037741:Fullerenes; D009124:Muscle Proteins; C039728:X-Protein, muscle, Oryctolagus cuniculus; C069837:fullerene C60