Antioxidant diterpenoids from the roots of Salvia barrelieri.
BACKGROUND
The phytochemical and biological studies carried out on Salvia species showed that their extracts and constituents have various biological activities.


OBJECTIVE
The aim of this study was the isolation of diterpenoids from the roots of Salvia barrelieri Ettling and the determination of the antioxidant activity.


METHODS
Chromatographic methods were used for fractionation and isolation, respectively. Structure elucidation was established by spectroscopic methods. Five antioxidant assays were performed.


RESULTS
Three new abietane diterpenoids barreliol, royleanone 12-methyl ether and 7-epi-salviviridinol, and six known diterpenoids, with a known dammarane triterpenoid, pyxinol were isolated. The absolute stereochemistry of pyxinol was confirmed by X-ray analysis.


CONCLUSIONS
Taxodione exhibited the highest antioxidant activity among the tested compounds.
Kolak
Ufuk
U
Department of General and Analytical Chemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey. ufukkolak@yahoo.com
Kabouche
Ahmed
A
Oztürk
Mehmet
M
Kabouche
Zahia
Z
Topçu
Gülaçtl
G
Ulubelen
Ayhan
A
D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D027544:Salvia / Q000737:chemistry*; D019207:beta Carotene / Q000737:chemistry
D000975:Antioxidants; D004224:Diterpenes; D019207:beta Carotene