title: Anti-interferon-gamma autoantibody in a patient with disseminated Mycobacterium avium complex.
abstract: We report the case of a 44-year-old woman with disseminated Mycobacterium avium complex (MAC) infection involving multiple bone lesions despite a normal healthy status until 6 months previously. Because she was suspected to have acquired immunodeficiency, we tested interferon (IFN)-gamma production by peripheral blood mononuclear cells (PBMC) after phytohemagglutinin (PHA) or anti-CD3 stimulation, and found that these cells produced no, or undetectable, levels of IFN-gamma in the presence of the patient's plasma, but produced nearly normal levels of IFN-gamma in the presence of healthy donor plasma. Since the IgG fraction of the patient's plasma was capable of blocking in vitro responses to IFN-gamma, the cause of disseminated MAC infection in this case appeared to be anti-IFN-gamma autoantibodies. To reduce the titer of anti-IFN-gamma autoantibodies, the patient received intravenous immunoglobulin (IVIG). However, titer of autoantibodies changed little compared to that before IVIG administration. According to our literature search, this is only the second case of disseminated MAC infection associated with anti-IFN-gamma autoantibodies in Japan.
authors.affiliation: Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, and Nishi-Niigata Chuo National Hospital, Niigata, Japan. tkoya@med.niigata-u.ac.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Koya
authors.forename: Chikako
authors.initials: C
authors.lastname: Tsubata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kagamu
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Koyama
authors.forename: Masachika
authors.initials: M
authors.lastname: Hayashi
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Kuwabara
authors.forename: Takui
authors.initials: T
authors.lastname: Itoh
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Toshinori
authors.initials: T
authors.lastname: Takada
authors.forename: Fumitake
authors.initials: F
authors.lastname: Gejyo
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity / Q000187:drug effects; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007371:Interferon-gamma / Q000276:immunology*; D007564:Japan; D015269:Mycobacterium avium Complex / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D007371:Interferon-gamma