Gliosarcoma with osteosarcomatous features: a short illustrated review.
BACKGROUND
Gliosarcoma is a rare, malignant, biphasic brain tumor formed by both glioblastoma and sarcomatous components. Various lines of differentiation are described in the latter component, but most commonly fibrosarcomatous and pleomorphic sarcoma are present. Osteosarcomatous features are exceedingly rare.


OBJECTIVE
We report a case of gliosarcoma with osteosarcomatous features in a 33-year-old woman.


METHODS
Histologically, the sarcomatous portion displayed a typical pattern of fibrosarcoma associated with areas of osteoid formation.


CONCLUSIONS
Immunohistochemical glial fibrillary acid protein (GFAP) expression was seen only in the glioblastoma portion. Clinicopathological characteristics and radiological data of this rare condition were reviewed. Possible differential diagnoses and potential histogenesis were also discussed.
Charfi
Slim
S
Pathology Department, Habib Bourguiba University Hospital, El Ain Road, 3029 Sfax, Tunisia. charfislim@gmail.com
Ayadi
Lobna
L
Khabir
Abdelmajid
A
Daoud
Emna
E
Kallel
Rim
R
Kharrat
Oussama
O
Mnif
Zeineb
Z
Boudawara
Zaher
Z
Makni
Saloua
S
Boudawara
Tahya
T
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D049109:Cell Proliferation; D004475:Ectoderm / Q000378:metabolism / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000378:metabolism; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D018316:Gliosarcoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D006261:Headache / Q000209:etiology; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D011859:Radiography; D011878:Radiotherapy; D012086:Reoperation; D015996:Survival Rate; D015354:Vision, Low / Q000209:etiology; D014839:Vomiting / Q000209:etiology
D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein