Vitamin D and tuberculosis.
Tuberculosis is highly prevalent worldwide, accounting for nearly two million deaths annually. Vitamin D influences the immune response to tuberculosis, and vitamin D deficiency has been associated with increased tuberculosis risk in different populations. Genetic variability may influence host susceptibility to developing active tuberculosis and treatment response. Studies examining the association between genetic polymorphisms, particularly the gene coding for the vitamin D receptor (VDR), and TB susceptibility and treatment response are inconclusive. However, sufficient evidence is available to warrant larger epidemiologic studies that should aim to identify possible interactions between VDR polymorphisms and vitamin D status.
Chocano-Bedoya
Patricia
P
Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Ronnenberg
Alayne G
AG
D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D009752:Nutritional Status; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000276:immunology*
D018167:Receptors, Calcitriol; D014807:Vitamin D