DNA replication reaches the breaking point.
DNA strand breaks that result in stalled or damaged replication forks can be detrimental to the DNA replication process. In this issue, Doksani et al. (2009) examine the impact of a single double-stranded DNA break on replication in the budding yeast, Saccharomyces cerevisiae.
Petrini
John H J
JH
Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA. petrinij@mskcc.org
D053903:DNA Breaks, Double-Stranded; D004261:DNA Replication; D016196:S Phase; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics* / Q000378:metabolism