title: Approach to design push-pull osmotic pumps.
abstract: Despite more than 30 years of clinical use, only few studies have been published reporting on the release mechanism underlying the drug delivery from push-pull osmotic pumps (PPOP). The aim of this study is to understand which factors have an effect on the drug delivery for modelling the drug release and to develop a mathematical model predictive of the drug release kinetics. The influence of the drug property was tested on two model drugs, isradipine (ISR) and chlorpheniramine (CPA) which are respectively practically insoluble and freely soluble. Results show that, regardless of the drug properties which do not significantly affect the drug delivery, the release kinetics is mainly controlled by four factors, (i) the PEG proportion in the membrane, (ii) the tablet surface area, (iii) the osmotic agent proportion and (iv) the drug layer polymer grade. The influence of each key formulation factors on the release mechanism was investigated defining their applicability range. A mathematical approach was developed to predict the drug delivery kinetics varying the PPOP controlling factors and helps to more efficiently design PPOP.
authors.affiliation: Novartis Pharma AG, Technical R&D, Basel, Switzerland. vincent.malaterre@novartis.com
authors.forename: Vincent
authors.initials: V
authors.lastname: Malaterre
authors.forename: Joerg
authors.initials: J
authors.lastname: Ogorka
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Loggia
authors.forename: Robert
authors.initials: R
authors.lastname: Gurny
mesh_terms: D002744:Chlorpheniramine / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D017275:Isradipine / Q000493:pharmacokinetics; D015233:Models, Statistical; D009995:Osmosis; D011092:Polyethylene Glycols / Q000493:pharmacokinetics; D013607:Tablets / Q000493:pharmacokinetics*
chemical_list: D013607:Tablets; D002744:Chlorpheniramine; D011092:Polyethylene Glycols; D017275:Isradipine