title: Ocular manifestations of crystal methamphetamine use.
abstract: Numerous medical sequelae associated with illicit drug use have been reported. Nevertheless, there has been scarce documentation of the effects of these drugs on the eyes. Drug-induced ocular symptoms include decreased visual acuity, disturbances in perception, and even flashbacks. Methamphetamine (METH) is a highly addictive drug whose abuse has spread worldwide during the past two decades. METH abuse is associated with many adverse psychiatric and medical consequences including strokes and psychosis. METH-induced ophthalmic complications are rarely discussed but include retinal vasculitis, episcleritis, panophthalmitis, endophthalmitis, scleritis, retinopathy, corneal ulceration, and transient visual losses. Because the drug has shown a marked increase in the prevalence of its use amongst pregnant women, there has also been an increase of drug-induced complications in fetuses and newborn babies. These complications need to be further detailed and studied. Herein, the authors report on the ocular complications associated with METH abuse. They also discuss some potential mechanisms for the toxic effects of the drug on that system.
authors.affiliation: Department of Genetics, Cell Biology, & Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA. Hazin@fas.harvard.edu
authors.forename: Ribhi
authors.initials: R
authors.lastname: Hazin
authors.forename: Jean Lud
authors.initials: JL
authors.lastname: Cadet
authors.forename: Malik Y
authors.initials: MY
authors.lastname: Kahook
authors.forename: Dunia
authors.initials: D
authors.lastname: Saed
mesh_terms: D019969:Amphetamine-Related Disorders / Q000209:etiology / Q000503:physiopathology*; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D015835:Ocular Motility Disorders / Q000209:etiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine