B cell precursors are targets for Salmonella infection.
We previously reported that, in mice, B cells are a reservoir for bacteria during Salmonella infection. Here, we show that, within the bone marrow, B cells and their precursors are targeted for infection by Salmonella enterica serovar typhimurium. Our data suggest that B cells within the bone marrow may be a bacterial niche during chronic Salmonella infection.
Castro-Eguiluz
Denisse
D
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados (CINVESTAV), DF, Mexico.
Pelayo
Rosana
R
Rosales-Garcia
Victor
V
Rosales-Reyes
Roberto
R
Alpuche-Aranda
Celia
C
Ortiz-Navarrete
Vianney
V
D000818:Animals; D015169:Colony Count, Microbial; D051379:Mice; D008807:Mice, Inbred BALB C; D054448:Precursor Cells, B-Lymphoid / Q000382:microbiology*; D012481:Salmonella Infections, Animal / Q000382:microbiology* / Q000473:pathology*; D012486:Salmonella typhimurium / Q000472:pathogenicity*