title: The evolution of cerebral revascularization surgery.
abstract: Among the relatively few surgeons to be awarded the Nobel Prize was Alexis Carrel, a French surgeon and pioneer in revascularization surgery at the turn of the 20th century. The authors trace the humble beginnings of cerebral revascularization surgery through to the major developments that helped shape the modern practice of cerebral bypass surgery. They discuss the cornerstone studies in the development of this technique, including the Extracranial/Intracranial Bypass Study initiated in 1977. Recent innovations, including modern techniques to monitor cerebral blood flow, microanastomosis techniques, and ongoing trials that play an important role in the evolution of this field are also evaluated.
authors.affiliation: Department of Neurosurgery, Stanford University Medical Center, Stanford, California 94305, USA.
authors.forename: Melanie G
authors.initials: MG
authors.lastname: Hayden
authors.forename: Marco
authors.initials: M
authors.lastname: Lee
authors.forename: Raphael
authors.initials: R
authors.lastname: Guzman
authors.forename: Gary K
authors.initials: GK
authors.lastname: Steinberg
mesh_terms: D000818:Animals; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D002548:Cerebral Revascularization / Q000266:history* / Q000379:methods*; D002561:Cerebrovascular Disorders / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D004195:Disease Models, Animal; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008866:Microsurgery / Q000379:methods / Q000639:trends; D008991:Monitoring, Physiologic / Q000379:methods / Q000639:trends; D019635:Neurosurgical Procedures / Q000266:history* / Q000379:methods*; D014656:Vascular Surgical Procedures / Q000295:instrumentation / Q000379:methods