Multilocus Bayesian meta-analysis of gene-disease associations.
Meta-analysis is a vital tool in genetic epidemiology. However, meta-analyses to identify gene-disease associations are compromised when contributing studies have typed partially overlapping sets of markers. Currently, only marginal analyses are possible, and these are restricted to the subset of studies typing that marker. This does not allow full use of available data and leads to the confounding of marker effects by closely associated markers. We present a Bayesian approach that exploits prior information on underlying haplotypes to allow multi-marker analysis incorporating data from all relevant studies of a gene or region, irrespective of the markers typed. We present results from application of our approach to data on a possible association between PDE4D and ischemic stroke.
Newcombe
Paul J
PJ
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, WC1E 7HT London, UK.
Verzilli
Claudio
C
Casas
Juan P
JP
Hingorani
Aroon D
AD
Smeeth
Liam
L
Whittaker
John C
JC
D001499:Bayes Theorem; D003198:Computer Simulation; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000235:genetics
D005819:Genetic Markers; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4