title: Intracranial pressure in patients with sepsis.
abstract: BACKGROUND
  In sepsis the brain is frequently affected although there is no infection of the CNS (septic encephalopathy). One possible cause of septic encephalopathy is failure of the blood-brain barrier. Brain edema has been documented in animal models of sepsis. Aggressive fluid resuscitation in the early course of sepsis improves survival and is standard practice. We hypothesized that aggressive fluid administration will increase intracranial pressure (ICP) and may cause critical reductions in cerebral perfusion pressure (CPP).
  
  
  METHODS
  Patients with sepsis were investigated daily on up to four consecutive days in the intensive care unit. Mean arterial blood pressure (MAP) and blood flow velocity in the middle cerebral artery were monitored for one hour each day. ICP was calculated non-invasively from MAP and flow velocity data. S-100beta was determined daily.
  
  
  RESULTS
  Fifty-two measurements were performed in 16 patients. ICP could be determined in 45 measurements in 15 patients. Seven patients had an ICP > 15 mmHg and 11 patients had a CPP < 60 mmHg on at least 1 day. We found no significant correlation between ICP and fluid administration, but low CPP was significantly correlated with elevated S-100beta (r = -0.47, p = 0.001).
  
  
  CONCLUSIONS
  Further research is needed to determine the role of ICP/CPP monitoring in patients with sepsis.
authors.affiliation: Department of Anaesthesia, Operative Intensive Care Unit, University Hospital Basel, Spitalstrasse 21, CH-4031 Basel, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Pfister
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
authors.forename: P
authors.initials: P
authors.lastname: Smielewski
authors.forename: M
authors.initials: M
authors.lastname: Siegemund
authors.forename: S P
authors.initials: SP
authors.lastname: Strebel
authors.forename: S
authors.initials: S
authors.lastname: Rüegg
authors.forename: S C U
authors.initials: SC
authors.lastname: Marsch
authors.forename: H
authors.initials: H
authors.lastname: Pargger
authors.forename: L A
authors.initials: LA
authors.lastname: Steiner
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow / Q000502:physiology; D018805:Sepsis / Q000503:physiopathology*; D018709:Statistics, Nonparametric; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods