Exercise, inflammation, and innate immunity.
Exercise has beneficial effects on chronic disease, and the drive to understand the mechanisms of these benefits is strong. This article presents several compelling potential mechanisms for the anti-inflammatory effect of exercise, including reduced percentage of body fat and macrophage accumulation in adipose tissue, muscle-released interleukin-6 inhibition of tumor necrosis factor-a, and the cholinergic anti-inflammatory pathway.
Woods
Jeffrey A
JA
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 South Goodwin Avenue, Urbana, IL 6180, USA. woods1@uiuc.edu
Vieira
Victoria J
VJ
Keylock
K Todd
KT
D000818:Animals; D002908:Chronic Disease; D015444:Exercise / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation