Phylogenetics, evolution, and medical importance of polyomaviruses.
The increasing frequency of tissue transplantation, recent progress in the development and application of immunomodulators, and the depressingly high number of AIDS patients worldwide have placed human polyomaviruses, a group of pathogens that can become reactivated under the status of immunosuppression, suddenly in the spotlight. Since the first description of a polyomavirus a half-century ago in 1953, a multiplicity of human and animal polyomaviruses have been discovered. After reviewing the history of research into this group, with a special focus is made on the clinical importance of human polyomaviruses, we conclude by elucidating the phylogenetic relationships and thus evolutionary history of these viruses. Our phylogenetic analyses are based on all available putative polyomavirus species as well as including all subtypes, subgroups, and (sub)lineages of the human BK and JC polyomaviruses. Finally, we reveal that the hypothesis of a strict codivergence of polyomaviruses with their respective hosts does not represent a realistic assumption in light of phylogenetic findings presented here.
Krumbholz
Andi
A
Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans-Knoell-Strasse 2, 07745 Jena, Germany. andi.krumbholz@med.uni-jena.de
Bininda-Emonds
Olaf R P
OR
Wutzler
Peter
P
Zell
Roland
R
D000818:Animals; D001739:BK Virus / Q000235:genetics; D019143:Evolution, Molecular; D016679:Genome, Viral; D006801:Humans; D007577:JC Virus / Q000235:genetics; D010802:Phylogeny; D011120:Polyomavirus / Q000235:genetics*; D027601:Polyomavirus Infections / Q000175:diagnosis / Q000821:virology*; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics
D014764:Viral Proteins