[The role of protein kinase SAPK/JNK in cell responses to low-intensity nonionizing radiation].
The effect of low-intensity lases light (0.2 mW/cm2, 632.8 nm, exposure time 1 min) or centimeter waves (8.15-18 GHz, 1 W/cm2, exposure time 1 h) on PhosphoSAPK/JNK production in mice lymphocytes was investigated. Normal isolated spleen lymphocytes or cells incubated previously with geldanamycin, an inhibitor of heat shock protein 90 (HSP90), were used in the experiments. A significant stimulation of PhosphoSAPK/JNK production in lymphocytes after treatment with laser light or microwaves has been shown in both cell models. It was proposed that the activation of SAPK/JNK signal pathway plays one of the central roles in cellular stress response to low-power nonionizing radiation.
Cherenkov
D A
DA
Novoselova
E G
EG
Khrenov
M O
MO
Glushkova
O V
OV
Lunin
S M
SM
Novoselova
T V
TV
Fesenko
E E
EE
D000818:Animals; D016227:Benzoquinones / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D047029:Lactams, Macrocyclic / Q000494:pharmacology; D007834:Lasers; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D048670:MAP Kinase Kinase 4 / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008872:Microwaves; D010750:Phosphoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D013312:Stress, Physiological / Q000187:drug effects / Q000528:radiation effects*; D013997:Time Factors
D016227:Benzoquinones; D004791:Enzyme Inhibitors; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D010750:Phosphoproteins; D048670:MAP Kinase Kinase 4; C001277:geldanamycin