title: IL-18 105 A>C polymorphism contributes to renal manifestations in patients with SLE.
abstract: Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective tissue disorder characterized by various aberrations including increased production of IL-18. As IL-18 105 A>C polymorphic variants have been linked to increased production of this cytokine, we investigated the prevalence of IL-18 105 A>C (rs549908) polymorphic variants in SLE patients (n = 111) and controls (n = 152). There were no significant differences in the distribution of IL-18 105 A>C polymorphic variants in SLE patients and controls. However, there was a significant association between the IL-18 105 AA genotype (recessive model) and renal manifestations OR = 3.360 (1.523–7.415, P = 0.0039) and the P value remained statistically significant after Bonferroni correction (P corr = 0.0351).Our findings indicate that the IL-18 105 AA genotype variant can contribute to renal manifestations in patients with SLE.
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 Święcickiego St., 60-781 Poznan, Poland.
authors.forename: Teresa
authors.initials: T
authors.lastname: Warchoł
authors.forename: Margarita
authors.initials: M
authors.lastname: Lianeri
authors.forename: Mariusz
authors.initials: M
authors.lastname: Wudarski
authors.forename: Jan K
authors.initials: JK
authors.lastname: Lacki
authors.forename: Paweł Piotr
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D008181:Lupus Nephritis / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence
chemical_list: D020382:Interleukin-18