Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis.
Covering: up to October 2008. Antitumor compounds produced by actinomycetes and novel derivatives generated by combinatorial biosynthesis are reviewed (with 318 references cited.) The different structural groups for which the relevant gene clusters have been isolated and characterized are reviewed, with a description of the strategies used for the generation of the novel derivatives and the activities of these compounds against tumor cell lines.
Olano
Carlos
C
Departamento de Biología Funcional and Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A.), Universidad de Oviedo, 33006, Oviedo, Spain.
Méndez
Carmen
C
Salas
José A
JA
D039903:Actinobacteria / Q000737:chemistry* / Q000235:genetics; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure
D000903:Antibiotics, Antineoplastic