Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparum malaria on oral therapy.
We determined the relationship between plasma and red blood cell concentrations of quinine in children with uncomplicated falciparum malaria from an endemic area of Amazonian region. Quinine was determined by high performance liquid chromatography with ultraviolet detection. In the steady state the ratio between plasma and red blood cell quinine concentration was 1.89 +/- 1.25 ranging from 1.05 to 2.34. This result demonstrated that quinine do not concentrate in red blood cell of Brazilian children and characterize the absence of interracial difference in this relationship.
Vieira
José L F
JL
Toxicology Laboratory, Para Federal University, Belem, PA, Brazil. jvieira@ufpa.br
Gomes
Andreza L S
AL
Borges
Larissa M G
LM
Guimarães
Erika R
ER
D000284:Administration, Oral; D000293:Adolescent; D000962:Antimalarials / Q000008:administration & dosage / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000737:chemistry*; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood* / Q000188:drug therapy; D011446:Prospective Studies; D011803:Quinine / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D000962:Antimalarials; D011803:Quinine