title: Systemic lupus erythematosus and vaccination.
abstract: Patients with systemic lupus erythematosus (SLE) are frequently immunodepressed making them more vulnerable to infections. Preventive vaccination is therefore warranted but has often been withheld owing to fears of a link between infection and autoimmunity, and the possibility of inducing or exacerbating lupus after vaccination. The data published in the literature suggest that vaccination of lupus patient is safe, except for live vaccines. Their efficacy is lower than in healthy subjects but protection seems to be sufficient. But further large-scale studies are required to confirm these statements.
authors.affiliation: Department of Internal Medicine, CHU RENNES, France. arnaud.millet@wanadoo.fr
authors.forename: Arnaud
authors.initials: A
authors.lastname: Millet
authors.forename: Olivier
authors.initials: O
authors.lastname: Decaux
authors.forename: Antoinette
authors.initials: A
authors.lastname: Perlat
authors.forename: Bernard
authors.initials: B
authors.lastname: Grosbois
authors.forename: Patrick
authors.initials: P
authors.lastname: Jego
mesh_terms: D015551:Autoimmunity / Q000276:immunology; D001424:Bacterial Infections / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D016867:Immunocompromised Host; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000276:immunology*; D012307:Risk Factors; D014611:Vaccination; D014777:Virus Diseases / Q000453:epidemiology / Q000517:prevention & control*