title: First detection of plasmid-encoded blaOXY beta-lactamase.
abstract: Three Klebsiella oxytoca isolates and one Klebsiella pneumoniae isolate from three children admitted to the Hematology Unit of Hospital Vall d'Hebron (Barcelona, Spain) exhibited a susceptibility pattern suggesting OXY beta-lactamase hyperproduction. All the isolates contained a 95-kb plasmid that harbored bla(OXY-1), which was transferred by electrotransformation but could not be self-transferred by conjugation. A qnrS1 gene was also harbored in the bla(OXY-1)-carrying plasmid. This is the first report of a plasmid-encoded OXY beta-lactamase.
authors.affiliation: Department of Microbiology, Hospital Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona, Spain. jjgonzalez@ir.vhebron.net
authors.forename: J J
authors.initials: JJ
authors.lastname: González-López
authors.forename: A
authors.initials: A
authors.lastname: Coelho
authors.forename: M N
authors.initials: MN
authors.lastname: Larrosa
authors.forename: S
authors.initials: S
authors.lastname: Lavilla
authors.forename: R
authors.initials: R
authors.lastname: Bartolomé
authors.forename: G
authors.initials: G
authors.lastname: Prats
mesh_terms: D015139:Blotting, Southern; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D007709:Klebsiella / Q000201:enzymology* / Q000235:genetics*; D041121:Klebsiella oxytoca / Q000187:drug effects / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics; D008297:Male; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics*; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001618:beta-Lactamases