Radiation dosimetry and biodistribution of (99m)Tc-ethylene dicysteine-deoxyglucose in patients with non-small-cell lung cancer.
OBJECTIVE
To assess the radiation dosimetry and biodistribution of (99m)Tc-labeled ethylene dicysteine deoxyglucose ((99m)Tc-EC-DG) in patients with non-small-cell lung cancer (NSCLC).


METHODS
Serial whole-body scans were acquired 0, 2, 4, 6 and 24 h after injection of (99m)Tc-EC-DG (925 MBq) in seven NSCLC patients. Radiation dosimetry, blood clearance and SPECT imaging of the primary tumor were assessed.


RESULTS
The critical organ was the bladder wall, with average radiation absorbed dose over all seven patients of 2.47x10(-2) mGy/MBq. The average effective dose equivalent and effective dose were 6.20x10(-3) mSv/MBq (6.89 mSv/1,110 MBq) and 5.90x10(-3) mSv/MBq (6.54 mSv/1,110 MBq), respectively. The primary tumor was visualized with SPECT in six patients. On final pathology, one patient had a granuloma, which did not enhance with (99m)Tc-EC-DG.


CONCLUSIONS
(99m)Tc-EC-DG has acceptable dosimetric and biodistribution properties as a diagnostic tumor-imaging agent. Future studies are planned to evaluate its diagnostic potential.
Schechter
Naomi R
NR
Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA. nschechter@radonc.ucsf.edu
Erwin
William D
WD
Yang
David J
DJ
Kim
E Edmund
EE
Munden
Reginald F
RF
Forster
Kenneth
K
Taing
Lina C
LC
Cox
James D
JD
Macapinlac
Homer A
HA
Podoloff
Donald A
DA
D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography; D011859:Radiography; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon; D001743:Urinary Bladder / Q000528:radiation effects
C471673:(99m)Tc ethylenedicysteine-deoxyglucose; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals