title: The prevalence of GAD antibodies in Korean women with gestational diabetes mellitus and their clinical characteristics during and after pregnancy.
abstract: BACKGROUND
  We conducted this research in order to evaluate the prevalence of glutamic acid decarboxylase antibodies (GADA) in Korean women with gestational diabetes mellitus (GDM), to identify the clinical characteristics of these women, and to gauge the prevalence of diabetes among them after childbirth.
  
  
  METHODS
  We studied 887 Korean women with GDM who were screened for GADA, and assessed their antepartum clinical characteristics and the outcomes of their pregnancies. At 6 weeks' postpartum, 75 g oral glucose tolerance tests were performed to determine the diabetic status of GDM women with GADA.
  
  
  RESULTS
  The prevalence of GADA in Korean women with GDM was 1.7%. Plasma glucose levels at 0- and 3-h during oral glucose tolerance tests were significantly different between GADA-positive and GADA-negative women with GDM. There were no significant differences between them in terms of age, body mass index, family history of diabetes, fasting insulin, and lipid profiles. However, GADA-positive women with GDM required insulin treatment during pregnancy more frequently than GADA-negative patients. The development of diabetes at early postpartum was significantly higher in GADA-positive women with GDM than those who were GADA negative.
  
  
  CONCLUSIONS
  The prevalence of GADA in Korean women with GDM was low. However, GADA-positive women with GDM are more susceptible to subsequently developing type 1 diabetes, even in the early postpartum period. Long-term follow up studies and intervention to prevent type 1 diabetes among GADA-positive GDM women are needed.
authors.affiliation: Division of Endocrinology & Metabolism, Department of Medicine, Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Yu
authors.forename: Sunmin
authors.initials: S
authors.lastname: Park
authors.forename: Hun-Sung
authors.initials: HS
authors.lastname: Kim
authors.forename: So-Young
authors.initials: SY
authors.lastname: Park
authors.forename: Chang Hoon
authors.initials: CH
authors.lastname: Yim
authors.forename: Ki Ok
authors.initials: KO
authors.lastname: Han
authors.forename: Hyun Koo
authors.initials: HK
authors.lastname: Yoon
authors.forename: Hak Chul
authors.initials: HC
authors.lastname: Jang
authors.forename: Ho Yeon
authors.initials: HY
authors.lastname: Chung
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D016022:Case-Control Studies; D015897:Comorbidity; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D016640:Diabetes, Gestational / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000201:enzymology / Q000276:immunology; D007723:Korea / Q000453:epidemiology; D049590:Postpartum Period / Q000097:blood* / Q000276:immunology; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012016:Reference Values
chemical_list: D001323:Autoantibodies; D005968:Glutamate Decarboxylase