[Analysis of L, E, and P selectins concentration in infants and young children with spastic bronchitis].
Spastic bronchitis in infants and young children is one of the most frequent causes of hospitalization in this age group. Both infectious and allergic inflammations lead to inflammation cells activation and their flow to the place of inflammation by the activation of adhesive molecules. One of groups of adhesive molecules are L, E and P selectins responsible for leucocytes migration through the vessel wall. The aim of the study was to assess the concentration of solved fractions of L, P and E selectins in infants and young children in the course of spastic bronchitis.


METHODS
Fifty four patients with spastic bronchitis (group I) including 32 with the first bronchitis (group IA) and 22 patients with recurrent bronchitis (at last the third one--group IB) were included into the study. Comparative group (group II) was consisted of 26 patients hospitalized due to other causes and with no bronchitis in the past. Patients were from 1 to 36 months of age. Among all patients solved fractions of selectins L, E and P were analyzed by ELISA tests.


RESULTS
Mean sL-selectin concentration in group I was 4126.3 ng/ml and in group II 4222.31 ng/ml and was not statistically significant. Concentrations of sL-selectin in the group of patients with the first episode of spastic bronchitis was 4099.37 ng/ml and in the group of patients with recurrent bronchitis was 4166 ng/ml and had no statistical difference. Mean sE-selectin concentration in group I was 205.49 ng/ml and in group II 214.50 ng/ml and was not statistically significant. Concentrations of sE-selectin in the group of patients with the first episode of spastic bronchitis was 195.22 ng/ml and in the group of patients with recurrent bronchitis was 220.43 ng/ml and had no statistical difference. Concentration of sP-selectin was assessed among 51 patients with bronchitis and among 26 patients from comparative group. Because of the lack of normal distribution values of sP-selectin concentrations were changed by decimal logarithm. Mean sP-selectin concentration in group I was 235.95 ng/ml and in group II 164.70 ng/ml. After logarithm change values of concentrations were: 2.249 and 2.005 and had statistical difference (p = 0.0221). Concentrations of sP-selectin in the group of patients with the first episode of spastic bronchitis was 234.0 ng/ml and in the group of patients with recurrent bronchitis was 238.20 ng/ml and after logarithm change concentrations were 2.26 in the group of patients with the first episode of spastic bronchitis and 2.24 in the group of patients with recurrent bronchitis and had no statistical difference.


CONCLUSIONS
On the ground of our study in infants and young children with spastic bronchitis increase of sP-selectin concentration was observed and sE-selectin and sL-selectin concentrations were the same.
Gasiorowska
Joanna
J
Department of Pediatrics, Allergology and Gastroenterology, Nicolaus Copernicus University of Torun, Collegium Medicum in Bydgoszcz, Poland. klped@cm.umk.pl
Czerwionka-Szaflarska
Mieczysława
M
Swincow
Grazyna
G
Stefańska
Anna
A
Odrowaz-Sypniewska
Grazyna
G
D001986:Bronchial Spasm / Q000150:complications / Q000378:metabolism*; D001991:Bronchitis / Q000150:complications / Q000378:metabolism*; D002675:Child, Preschool; D019040:E-Selectin / Q000378:metabolism*; D006801:Humans; D007223:Infant; D019041:L-Selectin / Q000378:metabolism*; D019007:P-Selectin / Q000378:metabolism*; D012008:Recurrence
D019040:E-Selectin; D019007:P-Selectin; D019041:L-Selectin