Comparison of the halving of tablets prepared with eccentric and rotary tablet presses.
The aim of this study was to compare the densification of powder mixtures on eccentric and rotary tablet presses and to establish relationships with the halving properties of the resulting scored tablets. This is an important problem because the recent guidelines of EU require verification of the equal masses of tablet halves. The models of Walker, Heckel, and Kawakita were used to describe the powder densification on the two machines. The calculated parameters revealed that the shorter compression cycle of rotary machines results in poorer densification and lower tablet hardness at a given compression force. This is manifested in poorer halving properties, which are influenced mainly by the hardness. Better densification improves the halving even at lower tablet hardness. This demonstrates that these parameters can be good predictors of tablet halving properties.
Sovány
T
T
Department of Pharmaceutical Technology, University of Szeged, Eötvös str. 6, Szeged, 6720, Hungary.
Kása
P
P
Pintye-Hódi
K
K
D019245:Compressive Strength; D011208:Powders / Q000737:chemistry*; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
D011208:Powders; D013607:Tablets