title: Characterization of star adhesive sealants based on PEG/dextran hydrogels.
abstract: Swellable PEG amine/dextran aldehyde composite materials are emerging as a controlled, biocompatible tissue adhesive. We explain how preservation of natural tissue amines provides biocompatibility for PEG/dextran that exceeds the stringent, destructive cyanide-based chemistry of cyanoacrylates, and adhere far better than fibrin glue. Strategic variations of material composition allow for the improvement of biocompatibility and adhesion strength. Material variations can be tailored to match the needs of specific tissue beds for an array of clinical applications. PEG/dextran cohesive properties are most responsive to variations in the PEG component (number of arms and solid content), while tissue/material adhesion strength is primarily determined by the number of aldehydes in the dextran.
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. nartzi@mit.edu
authors.forename: Natalie
authors.initials: N
authors.lastname: Artzi
authors.forename: Tarek
authors.initials: T
authors.lastname: Shazly
authors.forename: Cristina
authors.initials: C
authors.lastname: Crespo
authors.forename: Adriana Bon
authors.initials: AB
authors.lastname: Ramos
authors.forename: H Keith
authors.initials: HK
authors.lastname: Chenault
authors.forename: Elazer R
authors.initials: ER
authors.lastname: Edelman
mesh_terms: D000268:Adhesiveness; D001672:Biocompatible Materials / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000737:chemistry; D013329:Structure-Activity Relationship; D014014:Tissue Adhesives
chemical_list: D001672:Biocompatible Materials; D003911:Dextrans; D020100:Hydrogels; D014014:Tissue Adhesives; D011092:Polyethylene Glycols