title: An unusual case of 4-aminopyridine toxicity in a multiple sclerosis patient: epileptic disorder or toxic encephalopathy?
abstract: We report the case of a 45-year old female multiple sclerosis patient, who accidentally was overdosed with 4-aminopyridine which resulted in dystonic, choreathetoid type abnormal movements in the four limbs, motoric distress, confusion and opisthotonus. There is little known about 4-aminopyridine toxicity. There are only a few reported cases ranging from mild paresthesias to tonic-clonic seizures. 4-aminopyridine enhances neuronal conduction at neuromuscular synapses and is indicated in the treatment of selected neurological disorders including multiple sclerosis (MS) and myasthenia gravis, among others.
authors.affiliation: Dpt. of Neurology, Klina Regional Hospital, Brasschaat, Belgium. harald.de.cauwer@klina.be
authors.forename: H
authors.initials: H
authors.lastname: De Cauwer
authors.forename: Ph
authors.initials: P
authors.lastname: De Wolf
authors.forename: F
authors.initials: F
authors.lastname: Couvreur
authors.forename: L
authors.initials: L
authors.lastname: Mortelmans
mesh_terms: D015761:4-Aminopyridine / Q000009:adverse effects*; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy; D020258:Neurotoxicity Syndromes / Q000209:etiology; D026902:Potassium Channel Blockers / Q000009:adverse effects*
chemical_list: D026902:Potassium Channel Blockers; D015761:4-Aminopyridine