Th17 cells bounce off the fungal wall.
Th17 cells are thought to play a pivotal role in defenses against Candida albicans. van de Veerdonk et al. (2009) investigate components of the fungal cell wall and their cognate receptors on human peripheral blood mononuclear cells (PBMCs) responsible for IL-17 production and find a predominant role for mannan stimulation of the mannose receptor.
Levitz
Stuart M
SM
University of Massachusetts Medical School, 364 Plantation Street, LRB317, Worcester, MA 01605, USA. stuart.levitz@umassmed.edu
D002176:Candida albicans / Q000276:immunology*; D002473:Cell Wall / Q000276:immunology; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000382:microbiology*; D008351:Mannans / Q000276:immunology; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D037181:Lectins, C-Type; D008351:Mannans; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface