title: Potential of bioactive glass particles of different size ranges to affect bone formation in interproximal periodontal defects in dogs.
abstract: BACKGROUND
  The aim of this study was to compare the potential of bioactive glass particles of different size ranges to affect bone formation in periodontal defects, using the guided tissue regeneration model in dogs.
  
  
  METHODS
  In six dogs, 2-wall intrabony periodontal defects were surgically created and chronified on the mesial surfaces of mandibular third premolars and first molars bilaterally. After 1 month, each defect was randomly assigned to treatment with bioabsorbable membrane in association with bioactive glass with particle sizes between 300 and 355 microm (group 1) or between 90 and 710 microm (group 2), membrane alone (group 3), or negative control (group 4). The dogs were sacrificed 12 weeks after surgeries, and histomorphometric measurements were made of the areas of newly formed bone, new mineralized bone, and bioactive glass particle remnants.
  
  
  RESULTS
  With regard to the area of bioactive glass particle remnants, there was a statistically significant difference between groups 1 and 2, favoring group 1. There were greater areas of mineralized bone in groups 1 and 2 compared to groups 3 and 4 (P <0.05).
  
  
  CONCLUSIONS
  The bioactive glass particles of small size range underwent faster resorption and substitution by new bone than the larger particles, and the use of bioactive glass particles favored the formation of mineralized bone.
authors.affiliation: Department of Bucco-Maxillo-Facial Surgery and Traumatology and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
authors.forename: Maria Emília M C
authors.initials: ME
authors.lastname: Felipe
authors.forename: Patrícia F
authors.initials: PF
authors.lastname: Andrade
authors.forename: Arthur B
authors.initials: AB
authors.lastname: Novaes
authors.forename: Márcio F M
authors.initials: MF
authors.lastname: Grisi
authors.forename: Sérgio L S
authors.initials: SL
authors.lastname: Souza
authors.forename: Mário
authors.initials: M
authors.lastname: Taba
authors.forename: Daniela B
authors.initials: DB
authors.lastname: Palioto
mesh_terms: D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D004285:Dogs; D005898:Glass; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008567:Membranes, Artificial; D010316:Particle Size; D011897:Random Allocation
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial