title: Psychoneuroimmunology of stroke.
abstract: Stroke is the major cause of disability in the Western world and is the third greatest cause of death, but there are no widely effective treatments to prevent the devastating effects of stroke. Extensive and growing evidence implicates inflammatory and immune processes in the occurrence of stroke and particularly in the subsequent injury. Several inflammatory mediators have been identified in the pathogenesis of stroke including specific cytokines, adhesion molecules, matrix metalloproteinases, and eicosanoids. An early clinical trial suggests that inhibiting interleukin-1 may be of benefit in the treatment of acute stroke.
authors.affiliation: Faculty of Life Sciences, Michael Smith Building (C2210), University of Manchester, Acker Street, Manchester M13 9PT, UK. r.a.skinner@postgrad.manchester.ac.uk
authors.forename: Robert
authors.initials: R
authors.lastname: Skinner
authors.forename: Rachel
authors.initials: R
authors.lastname: Georgiou
authors.forename: Peter
authors.initials: P
authors.lastname: Thornton
authors.forename: Nancy
authors.initials: N
authors.lastname: Rothwell
mesh_terms: D016207:Cytokines / Q000502:physiology; D006801:Humans; D011598:Psychoneuroimmunology; D020521:Stroke / Q000276:immunology
chemical_list: D016207:Cytokines