title: Intracellular flow in optic nerve axons: a mechanism for cell death in glaucoma.
abstract: OBJECTIVE
  In glaucoma, elevated intraocular pressure causes a progressive loss of retinal ganglion cells and results in optic neuropathy. The authors propose a potential mechanism for cell death, whereby elevated intraocular pressure causes fluid to permeate axonal membranes, creating a passive intracellular fluid flow within the axons. It is hypothesized that this intracellular flow locally depletes the adenosine triphosphate (ATP) concentration, disrupting axonal transport and leading to cell death.
  
  
  METHODS
  A mathematical model was developed that takes into account the biomechanical principles underpinning the proposed hypothesis, and was solved to determine the implications of the mechanism.
  
  
  RESULTS
  The model suggests that the raised intraocular pressures present in glaucoma are adequate to produce significant intracellular fluid flow. In the periphery of the optic nerve head, this flow may be sufficient to disrupt the diffusion of ATP and hence interrupt active axonal transport.
  
  
  CONCLUSIONS
  The mathematical model demonstrates that it is physically plausible that a passive intracellular fluid flow could significantly contribute to the pathophysiology of the retinal ganglion cell axon in glaucoma.
authors.affiliation: School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom. leah.band@nottingham.ac.
authors.forename: Leah R
authors.initials: LR
authors.lastname: Band
authors.forename: Cameron L
authors.initials: CL
authors.lastname: Hall
authors.forename: Giles
authors.initials: G
authors.lastname: Richardson
authors.forename: Oliver E
authors.initials: OE
authors.lastname: Jensen
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Siggers
authors.forename: Alexander J E
authors.initials: AJ
authors.lastname: Foss
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000473:pathology*; D016923:Cell Death; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D007424:Intracellular Fluid / Q000502:physiology*; D007429:Intraocular Pressure; D008962:Models, Theoretical; D009900:Optic Nerve / Q000503:physiopathology*; D009901:Optic Nerve Diseases / Q000503:physiopathology*
chemical_list: D000255:Adenosine Triphosphate