Impact of prolonged treatment with linezolid on the human gut flora.
A 79-year-old male was treated for 6 months with linezolid for prosthetic knee joint osteomyelitis. At the end of this 6-month period, quantitative stool cultures revealed partial loss of the normal gut flora and concomitant colonization by opportunistic pathogens such as Pseudomonas aeruginosa and other Gram-negatives. Follow-up cultures at 6 weeks after antibiotic discontinuation revealed restoration of the normal flora. Prolonged linezolid administration may lead to replacement of normal gut flora by pathogenic microorganisms, which under certain conditions might cause systemic infections.
Kofteridis
Diamantis P
DP
Department of Internal Medicine, University Hospital of Heraklion, PO Box 1352, 71110 Heraklion, Crete, Greece. kofterid@med.uoc.gr
Malliotakis
Polychronis
P
Maraki
Sofia
S
Christofaki
Maria
M
Samonis
George
G
D000081:Acetamides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000368:Aged; D002175:Candida / Q000187:drug effects / Q000472:pathogenicity; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000472:pathogenicity; D006094:Gram-Positive Bacteria / Q000187:drug effects; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000382:microbiology; D007720:Knee Prosthesis / Q000382:microbiology*; D000069349:Linezolid; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D023303:Oxazolidinones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
D000081:Acetamides; D023303:Oxazolidinones; D000069349:Linezolid