The role of peripheral opiate antagonists in pain medicine and perioperative care.
OBJECTIVE
Pre-clinical and clinical trials of peripheral opiate antagonists have shed new light on the effects of exogenous and endogenous opioids.


BACKGROUND
This article review preclinical studies and clinical opioid bowel disfunction trials.


CONCLUSIONS
If approved these drugs may offer potential solutions to important clinical problems in pain management.
Tanaka
Pedro Paulo
PP
CET/SBA do Hospital de Clinicas da Universidade Federal do Parana (UFPR), Curitiba, PR.
Moss
Jonathan
J
D003248:Constipation / Q000139:chemically induced; D006801:Humans; D045823:Ileus; D009271:Naltrexone / Q000031:analogs & derivatives / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D010149:Postoperative Pain / Q000517:prevention & control*; D011183:Postoperative Complications; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use
D009292:Narcotic Antagonists; D000644:Quaternary Ammonium Compounds; C032257:methylnaltrexone; D009271:Naltrexone