[Effects of Sarcandra glabra extract on immune activity in restraint stress mice].
OBJECTIVE
To study the protective effect of Sarcandra glabra extract (SGE) on immune system in restrained mice.


METHODS
The male C57BL/6 mice were randomly divided into normal control group, stress control group, 125, 500 mg x kg(-1) SGE group. The spleen lymphocyte suspensions of each group were prepared. The parameters of spleen T cells subsets, NK cell and NKT cell proportion and number was detected by Flow cytometry.


RESULTS
SGE regulated the balance of T cell subsets, increased the percent of NK cells and NKT cell proportion and number in restrained mice.


CONCLUSIONS
SGE has immunologic protective effect in restrained mice probably via the amelioration of immune cells proportion and number.
He
Rongrong
R
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. rongronghe66@163.com
Wang
Min
M
Li
Yifang
Y
Dai
Yi
Y
Duan
Yinghui
Y
Yao
Xinsheng
X
Kurihara
Hiroshi
H
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D055611:Natural Killer T-Cells / Q000187:drug effects / Q000276:immunology; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology
D004365:Drugs, Chinese Herbal