Naproxcinod, a new cyclooxygenase-inhibiting nitric oxide donator (CINOD).
BACKGROUND
COX-inhibiting nitric oxide donators (CINODs) are a new class of drugs that combine the actions of the parent COX inhibitor with nitric oxide (NO), with the aim of reducing potential toxicity of the parent drug, while maintaining its analgesic and anti-inflammatory effects. AZD3582 (Naproxcinod) is the first in the class of CINODs.


OBJECTIVE
To review the effects of NO donation, CINODS in general and naproxen in osteoarthritis (OA), based on literature in PubMed.


RESULTS
In preclinical and human studies, this drug produced similar analgesic and anti-inflammatory effects to its parent naproxen, with improved gastrointestinal safety in OA patients. The results of recent clinical trials, which were designed to study effects on blood pressure, are expected shortly, after peer-review.


CONCLUSIONS
As naproxen is considered the safest COX inhibitor choice from a cardiovascular perspective, AZD3582 has the potential to become a new drug treatment in patients with OA, in whom pain and function are not controlled by the use of analgesics.
Geusens
Piet
P
University Hasselt, University Hospital, The Netherlands. piet.geusens@scarlet.be
D000818:Animals; D051545:Cyclooxygenase 1 / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009288:Naproxen / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D020030:Nitric Oxide Donors / Q000494:pharmacology / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy / Q000201:enzymology
D016861:Cyclooxygenase Inhibitors; D020030:Nitric Oxide Donors; C111751:naproxen-n-butyl nitrate; D009288:Naproxen; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2