One-year mortality in coagulase-negative Staphylococcus and Staphylococcus aureus infective endocarditis.
The aim of this study was to investigate in-hospital mortality and 12-month mortality in patients with coagulase-negative Staphylococcus (CoNS) compared to Staphylococcus aureus (S. aureus) infective endocarditis (IE). We used a prospective cohort study of 66 consecutive CoNS and 170 S. aureus IE patients, collected at 2 tertiary university hospitals in Copenhagen (Denmark) and at 1 tertiary university hospital in Gothenburg (Sweden). Median (range) C-reactive protein at admission was higher in patients with S. aureus IE (150 mg/l (1-521) vs 94 mg/l (6-303); p<0.001), which may suggest a more serous infection. CoNS was associated with prosthetic valve IE (49% vs 24%; p<0.001) and median diagnostic delay was longer in CoNS IE patients (20 d (0-232) vs 9 d (0-132); p<0.001). In-hospital mortality was equally high in both groups but 25% of the CoNS IE patients had died after 1 y compared to 39% of patients with S. aureus IE (p =0.05). In conclusion, CoNS IE was associated with a long diagnostic delay and high in-hospital mortality, whereas post-discharge prognosis was better in this group of patients compared to patients with IE due to S. aureus.
Rasmussen
Rasmus V
RV
Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark. ravera02@geh.regionh.dk
Snygg-Martin
Ulrika
U
Olaison
Lars
L
Andersson
Rune
R
Buchholtz
Kristine
K
Larsen
Carsten T
CT
Hansen
Thomas F
TF
Køber
Lars
L
Hassager
Christian
C
Bruun
Niels E
NE
D000368:Aged; D003030:Coagulase; D003718:Denmark / Q000453:epidemiology; D004697:Endocarditis, Bacterial / Q000382:microbiology / Q000401:mortality*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000382:microbiology / Q000401:mortality*; D013210:Staphylococcus / Q000302:isolation & purification*; D013211:Staphylococcus aureus / Q000302:isolation & purification; D018709:Statistics, Nonparametric
D003030:Coagulase