title: The pathogenesis of pituitary tumors.
abstract: Recently there has been significant progress in our understanding of pituitary development, physiology, and pathology. New information has helped to clarify the classification of pituitary tumors. Epidemiologic analyses have identified a much higher incidence of pituitary tumors than previously thought. We review the pathogenetic factors that have been implicated in pituitary tumorigenesis and the application of novel targeted therapies that underscore the increasingly important role of the pathologist in determining accurate diagnoses and facilitating appropriate treatment of patients with these disorders.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Ontario Cancer Institute, Toronto, Ontario, Canada. sylvia.asa@uhn.on.ca
authors.forename: Sylvia L
authors.initials: SL
authors.lastname: Asa
authors.forename: Shereen
authors.initials: S
authors.lastname: Ezzat
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D000818:Animals; D002277:Carcinoma / Q000453:epidemiology / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D002454:Cell Differentiation; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015994:Incidence; D010911:Pituitary Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D009626:Terminology as Topic; D016896:Treatment Outcome