Association of homozygous SDF-1 3'A genotype with proliferative diabetic retinopathy.
Stromal cell-derived factor 1 (SDF-1) is involved in the development of experimental proliferative retinopathy. Since little data are available on the genetic predisposition or on biomarkers predicting the development of proliferative retinopathy, we assessed the distribution of the SDF-1 3'A genotype in 130 diabetic patients with retinopathy. In patients with proliferative retinopathy, the frequency of the homozygous SDF-1 3'A genotype was significantly higher than in patients with non-proliferative retinopathy (10.9% of PDR vs. 0 of NPDR, P = 0.01). This association was confirmed when type 2 diabetes patients were analysed separately (10.3% of PDR vs. 0 of NPDR, P = 0.03). The finding that homozygous carriers of the SDF-1 3'A genotype are more frequent in diabetes patients with proliferative retinopathy suggests a possible role of this genotype in the development of sight-threatening diabetic retinopathy.
Djuric
Zdenka
Z
Department of Internal Medicine I and Clinical Chemistry, Ruprecht-Karls University, Heidelberg, Germany. Zdenka.Djuric@med.uni-heidelberg.de
Sharei
Vahid
V
Rudofsky
Gottfried
G
Morcos
Michael
M
Li
Huiqing
H
Hammes
Hans-Peter
HP
Nawroth
Peter P
PP
Bierhaus
Angelika
A
Humpert
Per M
PM
Jonas
Jost B
JB
D000368:Aged; D000369:Aged, 80 and over; D001766:Blindness / Q000453:epidemiology / Q000235:genetics; D054377:Chemokine CXCL12 / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000473:pathology; D005260:Female; D005838:Genotype; D006442:Glycated Hemoglobin / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping
D054377:Chemokine CXCL12; D006442:Glycated Hemoglobin