Acute renal failure due to ureteral obstruction in a kidney transplant recipient with Candida albicans contamination of preservation fluid.
Reported rates of positive preservation fluid cultures range from 5% to 23%, with fungi accounting for 2-10% of all positive cultures. We report the case of a kidney transplant recipient who received a graft with preservation fluid contaminated by Candida albicans, who developed acute renal failure due to ureteral obstruction by fungus balls. The patient was treated with voriconazole with complete restoration of graft function. This rare clinical entity demonstrates the usefulness of pre-transplant cultures of preservation fluid, in order to identify a group of patients who could benefit from antifungal prophylaxis therapy and thereby prevent the need for graft nephrectomy.
Veroux
M
M
Department of Surgery, Transplantation and Advanced Technologies, Vascular Surgery and Organ Transplant Unit, University Hospital of Catania, Catania, Italy. veroux@unict.it
Corona
D
D
Giuffrida
G
G
Gagliano
M
M
Tallarita
T
T
Giaquinta
A
A
Zerbo
D
D
Cappellani
A
A
Veroux
P F
PF
D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology*; D000935:Antifungal Agents / Q000627:therapeutic use; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D004866:Equipment Contamination; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D019188:Organ Preservation Solutions; D014517:Ureteral Obstruction / Q000150:complications*
D000935:Antifungal Agents; D019188:Organ Preservation Solutions