Correcting autoimmune anomalies in autoimmune disorders by immunological means, employing the modified vaccination technique.
Our research group has developed a new vaccination technique in experimental animals that has the potential of correcting autoimmune anomalies in humans such as autoimmune disorders, cancer, and chronic infections, both prophylactically and therapeutically. The vaccination method is called Modified Vaccination Technique (MVT). The MVT necessitates the introduction of a purified target antigen (ag) and a specific antibody (ab) against the target ag in the form of immune complex (IC) to evoke the desired immune response outcome by ab information transfer in the injected recipient. The injected IC produces the same class of ab in the host, with the same specificity against the target ag, as resides in the inoculum. The MVT promises to provide a means of upregulating beneficial immune events and downregulating undesirable immune responses in individuals, thereby re-establishing normalcy/tolerance to self.
Barabas
Arpad Zsigmond
AZ
Department of Surgery, University of Calgary, Calgary, Alberta, Canada. barabas@ucalgary.ca
Cole
Chad Douglas
CD
Barabas
Arpad David
AD
Graeff
Richard Milton
RM
Lafreniere
Rene
R
Weir
Donald Mackay
DM
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy*; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control; D017634:Self Tolerance; D014611:Vaccination / Q000379:methods*
D000936:Antigen-Antibody Complex