Hydrangea dulcis folium preserves beta-cell mass in diabetic db/db mice.
The anti-diabetic efficacy of Hydrangea dulcis folium (HDF) was studied in db/db mice and their littermates (db/-). Supplementation of HDF (1% and 3%) decreased glucose level significantly by 2- and 4-fold and increased significantly insulin level by 3- and 4.5-fold compared to db/db mice (P<0.05). Administration of HDF (1% and 3%) ameliorates hyperglycemia and improves glucose homeostasis in db/db mice in a dose-dependent manner by preventing loss of beta-cell mass resulting in increase of insulin secretion. In addition, 3% HDF treatment significantly reduced the food intake, weight gain, and blood lipids in db/db mice.
Kim
Mi-Ja
MJ
Department of Food and Nutrition, Dongduk Women's University, 23-1 Wolgok-Dong, Sungbuk-Ku, Seoul 136-714, South Korea.
Leem
Kang-Hyun
KH
Kim
Hye Kyung
HK
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000235:genetics*; D004435:Eating / Q000187:drug effects; D005951:Glucose Tolerance Test; D031966:Hydrangea / Q000737:chemistry*; D007328:Insulin / Q000097:blood; D050417:Insulin-Secreting Cells / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010179:Pancreas / Q000166:cytology* / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts