Novel action of 7-O-galloyl-D-sedoheptulose isolated from Corni Fructus as a hypertriglyceridaemic agent.
OBJECTIVE
We investigated the lipid-lowering activity of 7-O-galloyl-D-sedoheptulose, an active component of Corni Fructus, and related mechanisms.


METHODS
Rats were fed a high-fructose diet for 6 days, followed by treatment with 7-O-galloyl-D-sedoheptulose, 5, 10 or 20 mg/kg per day, or fenofibrate (positive control).


RESULTS
The high-fructose diet induced an increase in body weight, hypertriglyceridaemia, hyperglycaemia and hypertension. Administration of 7-O-galloyl-D-sedoheptulose significantly reduced the levels of triglyceride in the serum and liver (being more effective than fenofibrate) but did not lead to changes in liver weight or hepatic function, whereas fenofibrate increased the liver weight markedly. The preventive effect of 7-O-galloyl-D-sedoheptulose against the accumulation of triglyceride and cholesterol was related to the up-regulation of peroxisome proliferator-activated receptor alpha expression.


CONCLUSIONS
The present study supports the role of 7-O-galloyl-D-sedoheptulose as a promising agent against hypertriglyceridaemia without hepatic side-effects.
Yokozawa
Takako
T
Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan. yokozawa@inm.u-toyama.ac.jp
Park
Chan Hum
CH
Noh
Jeong Sook
JS
Tanaka
Takashi
T
Cho
Eun Ju
EJ
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D029768:Cornus / Q000737:chemistry*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005632:Fructose / Q000008:administration & dosage; D006539:Heptoses / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism; D008297:Male; D047493:PPAR alpha / Q000378:metabolism; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
C540464:7-O-galloyl-D-sedoheptulose; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006539:Heptoses; D000960:Hypolipidemic Agents; D047493:PPAR alpha; D010936:Plant Extracts; D014280:Triglycerides; D005632:Fructose; D002784:Cholesterol