title: Recipient risk factors for graft failure in the cornea donor study.
abstract: OBJECTIVE
  To identify recipient factors that may be related to risk of corneal graft failure.
  
  
  METHODS
  Multicenter, prospective, double-masked, controlled clinical trial.
  
  
  METHODS
  One thousand ninety subjects undergoing corneal transplantation for a moderate-risk condition (principally Fuchs' dystrophy or pseudophakic corneal edema).
  
  
  METHODS
  Donor corneas were assigned using a random approach without respect to recipient factors, and surgeons were masked to information about the donor cornea, including donor age. Surgery and postoperative care were performed according to the surgeons' usual routines, and subjects were followed up for 5 years. Baseline factors were evaluated for their association with graft failure.
  
  
  METHODS
  Graft failure, defined as a regraft or a cloudy cornea that was sufficiently opaque to compromise vision for a minimum of 3 consecutive months.
  
  
  RESULTS
  Preoperative diagnosis of pseudophakic or aphakic corneal edema increased graft failure risk approximately 4-fold compared with Fuchs' dystrophy (27% vs. 7%). Prior glaucoma surgery with preoperative glaucoma medication use substantially increased the graft failure rate. Factors not strongly associated with graft failure included age, gender, diabetes, smoking, and graft size.
  
  
  CONCLUSIONS
  The risk of graft failure is significantly increased in eyes with pseudophakic or aphakic corneal edema compared with Fuchs' dystrophy, independent of lens status, and in eyes with a history of glaucoma.
  
  
  BACKGROUND
  Proprietary or commercial disclosure may be found after the references.
authors.affiliation: W. K. Kellogg Eye Center, The University of Michigan, Ann Arbor, Michigan, USA. cds@jaeb.org
authors.forename: Alan
authors.initials: A
authors.lastname: Sugar
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Tanner
authors.forename: Mariya
authors.initials: M
authors.lastname: Dontchev
authors.forename: Brad
authors.initials: B
authors.lastname: Tennant
authors.forename: Robert L
authors.initials: RL
authors.lastname: Schultze
authors.forename: Steven P
authors.initials: SP
authors.lastname: Dunn
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Lindquist
authors.forename: Robin L
authors.initials: RL
authors.lastname: Gal
authors.forename: Roy W
authors.initials: RW
authors.lastname: Beck
authors.forename: Craig
authors.initials: C
authors.lastname: Kollman
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mannis
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Holland
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001036:Aphakia, Postcataract / Q000150:complications; D003316:Corneal Diseases / Q000209:etiology*; D015715:Corneal Edema / Q000150:complications / Q000601:surgery; D016039:Corneal Transplantation; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005642:Fuchs' Endothelial Dystrophy / Q000150:complications / Q000601:surgery; D005901:Glaucoma / Q000150:complications / Q000601:surgery; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019591:Pseudophakia / Q000150:complications; D012307:Risk Factors; D014019:Tissue Donors