Farnesyl protein transferase inhibitory components of Polygonum multiflorum.
The methanolic extract of the roots of Polygonum multiflorum (Polygonaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone glycosides, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.
Kwon
Byoung-Mog
BM
Korea Research Institute of Bioscience and Biotechnology, KIST, Daejeon, 305-333, Korea.
Kim
Sung-Hoon
SH
Baek
Nam-In
NI
Lee
Sa Im
SI
Kim
Eun Jeong
EJ
Yang
Jae Heon
JH
Chae
Byeong Suk
BS
Lee
Jae Hyeok
JH
Park
Hee Wook
HW
Park
Jeong-Suk
JS
Kim
Dae Keun
DK
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001681:Biological Assay; D005591:Chemical Fractionation; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D018517:Plant Roots; D028502:Polygonum / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
D000880:Anthraquinones; D004791:Enzyme Inhibitors; D006027:Glycosides; D012997:Solvents; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase; D000432:Methanol