Epstein-Barr virus-positive diffuse large B-cell lymphoma carrying a t(9;14)(p13;q32) translocation.
We, herein, report a 75-year-old man with lymphoma who initially presented with disseminated disease involving the lung, followed by temporal regression, and finally died of disease progression. Lymph-node biopsy showed a morphology of diffuse large B-cell lymphoma (DLBCL), containing CD30(+) Reed-Sternberg-like cells. The lymphoma cells were stained by in situ hybridization (ISH) for Epstein-Barr virus (EBV)-encoded RNA, and the presence of the EBV genome was confirmed by the polymerase chain reaction. A cytogenetic study showed that the lymphoma cells carried a t(9;14)(p13;q32) translocation, and rearrangement of the PAX5 gene was determined by fluorescence ISH using a split signal probe. This case report is the first to identify t(9;14)(p13;q32) in EBV(+) DLBCL of the elderly, which was very recently listed among subtypes of DLBCL.
Ohno
Hitoshi
H
Department of Hematology, Takeda General Hospital, Kyoto, Japan. hitoshi-ono@fm2.seikyou.ne.jp
Nishikori
Momoko
M
Haga
Hironori
H
Isoda
Kotaro
K
D000368:Aged; D001706:Biopsy; D002883:Chromosomes, Human, Pair 14; D002899:Chromosomes, Human, Pair 9; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000473:pathology / Q000821:virology; D008297:Male; D014178:Translocation, Genetic