Development of a cold dialysate regeneration system for home hemodialysis.
OBJECTIVE
Because longer and/or more frequent dialysis has potential clinical benefits, home hemodialysis (HHD) systems should provide flexible renal replacement therapies. We propose a new cold dialysate regeneration system that requires 10 l per treatment for HHD.


METHODS
We designed a dialysate regeneration system using cold dialysate and 2 activated carbon columns alternatively switched between adsorption and desorption. Urea adsorption ratios were compared in three different conditions; cold dialysate (5.7 degrees C), normal dialysate (36.8 degrees C), and cold dialysate with washing. In vivo tests (n = 8) were conducted to validate this system.


RESULTS
The urea removal ratios were 20.0 +/- 1.7% in cold dialysate, 36.0 +/- 1.7% in normal dialysate, and 82.5 +/- 1.2% in cold dialysate with washing. In animal experiments, the urea reduction ratio was 60.9 +/- 6.3%, Kt/V was 1.0 +/- 0.2, and serum electrolytes remained stable.


CONCLUSIONS
The proposed cold dialysate regeneration system using a small volume of dialysate will be useful for HHD.
Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Mich., USA.
Ji Hyun
JH
Kim
Jeong Chul
JC
Kim
Jin-Hee
JH
Moon
Joong Yull
JY
Park
Kyoung Kap
KK
Lee
Eungtaek
E
Kang
Hee Chan
HC
Kim
Byoung Goo
BG
Min
Claudio
C
Ronco
D000327:Adsorption; D000818:Animals; D002606:Charcoal / Q000737:chemistry / Q000627:therapeutic use*; D003080:Cold Temperature; D015314:Dialysis Solutions / Q000737:chemistry / Q000627:therapeutic use; D004285:Dogs; D004867:Equipment Design; D006437:Hemodialysis, Home / Q000295:instrumentation*; D006801:Humans; D008297:Male; D014508:Urea / Q000737:chemistry*
D015314:Dialysis Solutions; D002606:Charcoal; D014508:Urea