6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase.
Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Boris
B
Brumshtein
Matilde
M
Aguilar-Moncayo
M Isabel
MI
García-Moreno
Carmen
C
Ortiz Mellet
José M
JM
García Fernández
Israel
I
Silman
Yoseph
Y
Shaaltiel
David
D
Aviezer
Joel L
JL
Sussman
Anthony H
AH
Futerman
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020134:Catalytic Domain; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D005962:Glucosylceramidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D006860:Hydrogen Bonding; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
C543923:6-amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin; D004791:Enzyme Inhibitors; D017485:1-Deoxynojirimycin; D001617:beta-Glucosidase; D005962:Glucosylceramidase