Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.
Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 microM and a therapeutic index (TI) of more than 25.
Li
Xiao-Nian
XN
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
Pu
Jian-Xin
JX
Du
Xue
X
Yang
Liu-Meng
LM
An
Hui-Mei
HM
Lei
Chun
C
He
Fei
F
Luo
Xiao
X
Zheng
Yong-Tang
YT
Lu
Yang
Y
Xiao
Wei-Lie
WL
Sun
Han-Dong
HD
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D017705:Lignans; C542030:tiegusanin G