Synthesis and DNA polymerase alpha and beta inhibitory activity of alkyl p-coumarates and related compounds.
trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases alpha and beta. Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases alpha and beta.
Kobe Pharmaceutical University, Kobe, Japan. nishi@kobepharma-u.ac.jp
Katsumi
K
Nishimura
Yukiko
Y
Takenaka
Manami
M
Kishi
Takao
T
Tanahashi
Hiromi
H
Yoshida
Chiaki
C
Okuda
Yoshiyuki
Y
Mizushina
D000818:Animals; D003373:Coumaric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004256:DNA Polymerase I / Q000037:antagonists & inhibitors / Q000737:chemistry*; D019951:DNA Polymerase beta / Q000037:antagonists & inhibitors / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
D003373:Coumaric Acids; D004791:Enzyme Inhibitors; D004952:Esters; D004256:DNA Polymerase I; D019951:DNA Polymerase beta