In vitro and in vivo therapeutic activity of ibuprofen against dermatophytes.
OBJECTIVE
To evaluate the in vitro and in vivo therapeutic activity of ibuprofen against dermatophytes.


METHODS
The period of study ranged from June to September 2008. For in vitro investigation of ibuprofen activity, measurement of colony diameter, and dry weight were employed against 4 isolated strains of dermatophytes from 46 patients (30-43 years) suffering from dermatophytoses at Morgan Hospital, Hilla City, Iraq in June 2008. For the in vivo evaluation of ibuprofen, rabbits as the main subjects, were infected with dermatophytes and treated with prepared ibuprofen cream (15 mg/gm).


RESULTS
In vitro application of ibuprofen showed cidal activity on 4 strains of dermatophytes at minimum inhibitory concentrations of 200 microg/ml. The infected rabbits were successfully cured of dermatophytoses after treatment with ibuprofen cream.


CONCLUSIONS
Based on in vitro and in vivo application, Ibuprofen can be used as a short-term cure for dermatophytoses.
Al-Janabi
Ali S
AS
Department of Clinical Laboratory, College of Pharmacy, University of Kerbala, Iraq. aljanabi_bio@yahoo.com
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D007052:Ibuprofen / Q000494:pharmacology*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D011817:Rabbits
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen