The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition.
Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products.
Crowe
Francesca L
FL
Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK. francesca.crowe@ceu.ox.ac.uk
Key
Timothy J
TJ
Allen
Naomi E
NE
Appleby
Paul N
PN
Roddam
Andrew
A
Overvad
Kim
K
Grønbaek
Henning
H
Tjønneland
Anne
A
Halkjaer
Jutte
J
Dossus
Laure
L
Boeing
Heiner
H
Kröger
Janine
J
Trichopoulou
Antonia
A
Dilis
Vardis
V
Trichopoulos
Dimitrios
D
Boutron-Ruault
Marie-Christine
MC
De Lauzon
Blandine
B
Clavel-Chapelon
Françoise
F
Palli
Domenico
D
Berrino
Franco
F
Panico
Salvatore
S
Tumino
Rosario
R
Sacerdote
Carlotta
C
Bueno-de-Mesquita
H Bas
HB
Vrieling
Alina
A
van Gils
Carla H
CH
Peeters
Petra H M
PH
Gram
Inger T
IT
Skeie
Guri
G
Lund
Eiliv
E
Rodríguez
Laudina
L
Jakszyn
Paula
P
Molina-Montes
Esther
E
Tormo
María J
MJ
Barricarte
Aurelio
A
Larrañaga
Nerea
N
Khaw
Kay-Tee
KT
Bingham
Sheila
S
Rinaldi
Sabina
S
Slimani
Nadia
N
Norat
Teresa
T
Gallo
Valentina
V
Riboli
Elio
E
Kaaks
Rudolf
R
D000367:Age Factors; D015992:Body Mass Index; D002136:Calcium, Dietary / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D004032:Diet; D002149:Energy Intake; D005060:Europe; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011506:Proteins / Q000008:administration & dosage; D012737:Sex Factors; D011795:Surveys and Questionnaires
D002136:Calcium, Dietary; D018970:Insulin-Like Growth Factor Binding Protein 1; D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D011506:Proteins; D007334:Insulin-Like Growth Factor I