Uridine diphosphoglucuronosyltransferase 1A7 gene polymorphism and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers.
OBJECTIVE
The aim of this study was to explore the relationship between UGT1A7 gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons (PAH)-exposed workers.


METHODS
Blood and urine samples of 140 PAH-exposed workers and 66 non-PAH-exposed workers were collected. The polymorphisms of UGT1A7, cytokinesis-block micronucleus (CBMN) and 1-hydroxypyrene were analyzed.


RESULTS
UGT1A7 codon 208 Arg carriers exhibited significantly higher CBMN frequencies than did the Trp/Trp (P < 0.05). Stratification analysis revealed that the significant association between CBMN frequencies and the polymorphisms of UGT1A7 Asn129Lys, Arg131Lys, and Trp208Arg was most pronounced. Moreover, higher CBMN frequencies were found among subjects with *3 allele than those with *1 allele (P = 0.008) in younger PAH-exposed workers.


CONCLUSIONS
Polymorphisms of UGT1A7 gene may alter the severity of PAH-induced chromosomal damage among the exposed workers.
National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Yadong
Y
Wang
Huawei
H
Duan
Yufei
Y
Dai
Ping
P
Bin
Juan
J
Cheng
Zufei
Z
Pan
Chuanfeng
C
Huang
Shuguang
S
Leng
Wen
W
Chen
Yuxin
Y
Zheng
D000328:Adult; D048749:Cytokinesis / Q000187:drug effects; D004249:DNA Damage; D005260:Female; D005787:Gene Frequency; D014453:Glucuronosyltransferase / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D020641:Polymorphism, Single Nucleotide / Q000187:drug effects*; D011721:Pyrenes
D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; D014453:Glucuronosyltransferase; C107611:UDP-glucuronosyltransferase, UGT1A7; C033146:1-hydroxypyrene