Fast attrition-enhanced deracemization of naproxen by a gradual in situ feed.
Grind and cure: Using the nonsteroidal anti-inflammatory drug naproxen, a novel concept is demonstrated to dramatically enhance the rate of the recently discovered process of deracemization using abrasive grinding. The process relies on a gradual feed of the racemic target material by an in situ conversion.
Noorduin
Wim L
WL
IMM Solid State Chemistry, Radboud University Nijmegen, The Netherlands.
Kaptein
Bernard
B
Meekes
Hugo
H
van Enckevort
Willem J P
WJ
Kellogg
Richard M
RM
Vlieg
Elias
E
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004951:Esterification; D007536:Isomerism; D009288:Naproxen / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen