Protein O-mannosylation: conserved from bacteria to humans.
Protein O-mannosylation is an essential modification in fungi and animals. Different from most other types of O-glycosylation, protein O-mannosylation is initiated in the endoplasmic reticulum by the transfer of mannose from dolichol monophosphate-activated mannose to serine and threonine residues of secretory proteins. In recent years, it has emerged that even bacteria are capable of O-mannosylation and that the biosynthetic pathway of O-mannosyl glycans is conserved between pro- and eukaryotes. In this review, we summarize the observations that have opened up the field and highlight characteristics of O-mannosylation in the different domains/kingdoms of life.
Department V Cell Chemistry, Heidelberg Institute for Plant Sciences, University of Heidelberg, Heidelberg, Germany.
Mark
M
Lommel
Sabine
S
Strahl
D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000502:physiology*; D005656:Fungal Proteins / Q000378:metabolism; D005658:Fungi / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D008358:Mannose / Q000378:metabolism*; D008364:Mannosyltransferases / Q000378:metabolism*; D010802:Phylogeny; D011134:Polysaccharides / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D012694:Serine / Q000378:metabolism; D013912:Threonine / Q000378:metabolism
D001426:Bacterial Proteins; D005656:Fungal Proteins; D011134:Polysaccharides; D013912:Threonine; D012694:Serine; D008364:Mannosyltransferases; D008358:Mannose