Automated synthesis of n.c.a. [18F]FDOPA via nucleophilic aromatic substitution with [18F]fluoride.
An improved, automated synthesis of [(18)F]FDOPA including four synthetic steps (fluorination, reductive iodination, alkylation and hydrolysis) is reported with each step optimized individually. In a home-made automatic synthesizer, 9064+/-3076 MBq of [(18)F]FDOPA were produced within 120 min from EOB (n=5). Radiochemical purity and enantiomeric excess were both >or= 95%. Specific activity was ca. 50 GBq/micromol at EOS. This automatically operable synthesis is well suited for the multi-patient-dose routine production of n.c.a. [(18)F]FDOPA.
Radiopharmacy, PET Center, Eberhard Karls University Tübingen, Germany.
B
B
Shen
W
W
Ehrlichmann
M
M
Uebele
H-J
HJ
Machulla
G
G
Reischl
D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D005462:Fluorine Radioisotopes; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; C054651:2-fluorodopa; D004295:Dihydroxyphenylalanine