No association between polymorphism of serotonin transporter gene and depression in Parkinson's disease in Chinese.
Depressive symptoms affect 40% to 50% of Parkinson's disease (PD) patients, and adversely impact their quality of life. The decrease of serotonin (5-HT) in the synaptic cleft is commonly considered as the cause of depression. The reuptake of 5-HT released into the synaptic cleft is mediated by the 5-HT transporter (5-HTT). Many studies have focused on the relationship between the 5-HTT-linked polymorphic region (5-HTTLPR) and depression. The present study is to investigate the association between the polymorphisms in the promoter of the 5-HTT gene (including 5-HTTLPR and rs25531), which determine either a higher or lower 5-HT uptake, and risk for depression of PD. Three hundred six idiopathic PD patients were recruited randomly from hospital clinic and the Center for Epidemiological Studies Depression Scale (CES-D) was used as the diagnosis or rating scale for depression. Polymerase Chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used and the patients' genotypes were divided as L(A), L(G), S(A), and S(G). We found no evidence for an association between variants of 5-HTTLPR and rs25531 alleles, and depressive symptoms in Chinese PD patients.
Department of Neurobiology and Neurology, Key Laboratory of Neurodegenerative Diseases for Ministry of Education, Beijing Institute of Geriatrics and Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China.
Jing-Lin
JL
Zhang
Jing-Fang
JF
Yang
Piu
P
Chan
D044466:Asian People / Q000235:genetics; D002681:China; D004252:DNA Mutational Analysis; D003866:Depressive Disorder / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic / Q000235:genetics; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D009435:Synaptic Transmission / Q000235:genetics
D005819:Genetic Markers; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin