Reproductive performance in diabetes mice with a special reference to uterine natural killer cells and placental growth factor.
To determine the effect of diabetes on reproductive performance, two kinds of diabetes mice, i.e., KK/TaJcl mice with Type-II diabetes and Streptozotocin-induced diabetes mice with Type-I diabetes, were used in this study. Particular attention was paid to uterine natural killer (uNK) cells and placental growth factor (PlGF). The number of fetuses, the fetal and placental weights in both diabetes mice were significantly decreased when compared to controls. Surprisingly, uNK cells in both diabetes mice persisted in the metrial gland even at the term of pregnancy. Although PlGF expression in both diabetes mice was significantly decreased, PlGF protein did not change. These results show that diabetes condition affects reproductive performance, particularly uNK cell behavior, but not PlGF production.
The United Graduate School of Veterinary Science, Yamaguchi University, Japan.
Thanmaporn
T
Phichitrasilp
Eiichi
E
Hondo
Worawut
W
Rerkamnuaychoke
Shoichi
S
Wakitani
Makoto
M
Sugiyama
Jumpei
J
Terakawa
Yasuo
Y
Kiso
D000818:Animals; D015153:Blotting, Western; D001835:Body Weight / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000276:immunology / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D007694:Killer Cells, Natural / Q000473:pathology*; D051379:Mice; D008813:Mice, Inbred ICR; D010920:Placenta / Q000166:cytology / Q000276:immunology*; D000072483:Placenta Growth Factor; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D012313:RNA / Q000737:chemistry / Q000235:genetics; D012098:Reproduction / Q000276:immunology / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction
C000608037:Pgf protein, mouse; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; D012313:RNA