[Osteoblast differentiation and bone formation].
Osteoblast lineage cells, which derive from mesenchymal stem cell, are an important target for development of bone anabolic agents. Osteoblasts synthesize bone matrix to execute bone formation, and play crucial roles in mineral metabolism, hematopoiesis and bone resorption as well. In the last decade, critical roles of several transcription factors in osteoblast differentiation have been demonstrated. The differentiation and fate of osteoblasts are also controlled by various extracellular signals, such as Hedgehog, Notch, Wnt and BMP. This short review describes recent advances, focusing on signaling molecules that affect bone mass through regulation of osteoblastic differentiation and function.
Watanabe
Ken
K
Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology (NCGG).
Ikeda
Kyoji
K
D000818:Animals; D001857:Bone Matrix / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D001862:Bone Resorption; D002454:Cell Differentiation / Q000235:genetics; D053823:Hedgehog Proteins / Q000502:physiology; D006410:Hematopoiesis; D006801:Humans; D051379:Mice; D008903:Minerals / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology*; D010012:Osteogenesis; D010281:Parathyroid Hormone; D051880:Receptors, Notch / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D051153:Wnt Proteins / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; D008903:Minerals; D010281:Parathyroid Hormone; D051880:Receptors, Notch; D014157:Transcription Factors; D051153:Wnt Proteins