TOPCONS: consensus prediction of membrane protein topology.
TOPCONS (http://topcons.net/) is a web server for consensus prediction of membrane protein topology. The underlying algorithm combines an arbitrary number of topology predictions into one consensus prediction and quantifies the reliability of the prediction based on the level of agreement between the underlying methods, both on the protein level and on the level of individual TM regions. Benchmarking the method shows that overall performance levels match the best available topology prediction methods, and for sequences with high reliability scores, performance is increased by approximately 10 percentage points. The web interface allows for constraining parts of the sequence to a known inside/outside location, and detailed results are displayed both graphically and in text format.
Bernsel
Andreas
A
Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91, Sweden.
Viklund
Håkan
H
Hennerdal
Aron
A
Elofsson
Arne
A
D000465:Algorithms; D020407:Internet; D008565:Membrane Proteins / Q000737:chemistry*; D011487:Protein Conformation; D015203:Reproducibility of Results; D012984:Software
D008565:Membrane Proteins