Salicylic acid-involved in lead tolerance associated with the maintenance of reducing conditions in mice.
Lead (Pb(2+)) intoxication may initiate many disorders in human and animals. In a previous study, we demonstrate that application of salicylic acid protects nuclear DNA integrity against Pb(2+) stress in mice. In this study, further evidence showed that the exogenous salicylic acid-involved in Pb(2+) tolerance in mice was associated with the maintenance of reducing conditions in cells, as revealed by an increased antioxidative enzyme activity, elevated reduced glutathione content and ratio to oxidised form of glutathione, and decreased lipid peroxidation. In addition, the presence of a 30 kD protein was tightly linked to the Pb(2+) detoxification.
College of Life and Chemistry Sciences, Shenyang Normal University, Shenyang, People's Republic of China.
Qiang
Q
Xu
Xin
X
Xu
Yingyi
Y
Zhang
Chunyan
C
Ma
Guangzhe
G
Li
Lin
L
Hao
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D007854:Lead / Q000378:metabolism / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D020156:Salicylic Acid / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D007854:Lead; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione; D020156:Salicylic Acid