Comparison of BNCT and GdNCT efficacy in treatment of canine cancer.
In this study efficacy of antineoplastic action of gadolinium NCT and boron NCT in cases of canine melanoma and osteosarcoma was compared. Canine spontaneous tumors, such as melanoma and osteosarcoma, have clinical common features with human malignancies, so these tumors in dogs can be considered as clinical model of human melanoma and osteosarcoma. The study has been carried out on 33 dogs with oral cavity melanoma and 9 dogs with osteosarcoma. Dogs with spontaneous melanoma of oral cavity and osteosarcoma of extremities were selected by the results of clinical examination. Irradiation was carried out at the NCT facility of the IRT MEPhI reactor. Neutron irradiation without boron or gadolinium was chosen as a control method to evaluate the efficacy of NCT.
Mitin
V N
VN
Russian Cancer Research Center of the RAMS, Kashirskoe shosse, 24, 115478 Moscow, Russia.
Kulakov
V N
VN
Khokhlov
V F
VF
Sheino
I N
IN
Arnopolskaya
A M
AM
Kozlovskaya
N G
NG
Zaitsev
K N
KN
Portnov
A A
AA
D000818:Animals; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000662:veterinary; D001896:Boron Compounds / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000662:veterinary*; D003131:Combined Modality Therapy; D004283:Dog Diseases / Q000532:radiotherapy* / Q000628:therapy; D004285:Dogs; D005682:Gadolinium / Q000627:therapeutic use; D006801:Humans; D008545:Melanoma / Q000532:radiotherapy / Q000662:veterinary; D009062:Mouth Neoplasms / Q000532:radiotherapy / Q000662:veterinary; D009369:Neoplasms / Q000532:radiotherapy / Q000628:therapy / Q000662:veterinary*; D017247:Neutron Capture Therapy / Q000662:veterinary*; D012516:Osteosarcoma / Q000532:radiotherapy / Q000662:veterinary; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000627:therapeutic use
D001896:Boron Compounds; D010649:Phenylalanine; D005682:Gadolinium; C033685:4-boronophenylalanine