Antimicrobial activity of hydroxylbenzenesulfonailides derivatives of chitosan, chitosan sulfates and carboxymethyl chitosan.
Chitosan, carboxymethyl chitosan (CMCS) and chitosan sulfates (CSS) with different molecular weight were modified by reacting with 4-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride or 2-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride to give 12 kinds of new hydroxylbenzenesulfonailides derivatives of them. The preparation conditions of the derivatives were discussed in this paper, and their structures were characterized by FT-IR and 13C NMR spectroscopy. The solubility of the derivatives was measured in the experiment. In addition, their antimicrobial activities against four bacteria and five crop-threatening pathogenic fungi were tested in the experiment. Besides, the rule and mechanism of their antibacterial activities were discussed in this paper.
Zhong
Zhimei
Z
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. zhimeihappy@126.com
Li
Pengcheng
P
Xing
Ronge
R
Liu
Song
S
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001554:Benzene / Q000737:chemistry*; D055598:Chemical Phenomena; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D012995:Solubility; D013696:Temperature; D014867:Water / Q000737:chemistry
D000890:Anti-Infective Agents; C480355:chitosan sulfate; D014867:Water; D048271:Chitosan; D001554:Benzene