Synthesized different derivatives of low molecular fucoidan extracted from Laminaria japonica and their potential antioxidant activity in vitro.
Six low molecular fucoidan (DFPS) derivatives were synthesized successfully, and their potential antioxidant activities were investigated employing various established in vitro systems. All DFPS derivatives possessed considerable antioxidant activity, and had stronger antioxidant ability than DFPS in certain tests. The benzoylated DFPS (PHDF) showed strongest scavenging activity on superoxide, hydroxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, however, DFPS exhibited greatest reducing power. Available data suggested that substituted groups of DFPS played an important role on antioxidant activity, and the mechanism on influence the antioxidant activity of samples of substituted group was indicated.
Wang
Jing
J
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.
Wang
Feng
F
Zhang
Quanbin
Q
Zhang
Zhongshan
Z
Shi
Xuelian
X
Li
Pengcheng
P
D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification*; D005609:Free Radicals / Q000737:chemistry; D007795:Laminaria / Q000737:chemistry*; D010084:Oxidation-Reduction; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification*; D017550:Spectroscopy, Fourier Transform Infrared
D016166:Free Radical Scavengers; D005609:Free Radicals; D011134:Polysaccharides; C007789:fucoidan