Effects of acute hypoxia tests on blood markers in high-level endurance athletes.
The aim of this study was to determine the response of blood markers to acute hypoxia in high-level endurance athletes before training based on "living high-training low" model. Thirty endurance athletes performed a hypoxic cycling test and spent 3 h at rest in a simulated altitude of 3,000 m. At the end of the hypoxic cycling test, the quantity of the natural antisense transcript of HIF-1alpha mRNA (aHIF) transcript increased significantly (+37%, P = 0.024). After 3-h exposure, at a simulated altitude of 3,000 m, the amount of HIF-1alpha mRNA increased significantly (+57%, P = 0.012). Moreover, a large inter-subject range was observed in response to the hypoxic cycling test and to the prolonged hypoxic exposure: -133%/+79% and -82%/+653% for HIF-1alpha mRNA, 69%/+324% and -76%/+229% for aHIF. This study shows a large inter-variability of blood markers in elite athletes in response to acute hypoxic exposure corroborating previous observations made in other populations.
Laboratoire de Biologie des Activités Physiques et Sportives, Faculté de Médecine, 63000 Clermont-Ferrand, France. remimounier@voila.fr
Rémi
R
Mounier
Vincent
V
Pialoux
Laurent
L
Schmitt
Jean-Paul
JP
Richalet
Paul
P
Robach
Jean
J
Coudert
Eric
E
Clottes
Nicole
N
Fellmann
D000293:Adolescent; D000328:Adult; D001158:Arteries / Q000737:chemistry; D015415:Biomarkers / Q000097:blood*; D001774:Blood Chemical Analysis; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology*; D013177:Sports / Q000502:physiology*; D055815:Young Adult
D015415:Biomarkers; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit