[The beta-fibrinogen gene polymorphism, fibrinogen level and platelet aggregation in patients with ischemic stroke].
We examined an association of the C-148T beta-fibrinogen gene polymorphism with fibrinogen level and platelet aggregation in patients with ischemic stroke and in people with vascular risk factors but no ischemic stroke. Among stroke patients, carriers of an -148T allele had significantly higher plasma fibrinogen level and platelet aggregation to norepinephrin compared to the C/C homozygotes. No significant differences in frequencies of a C-148 allele between stroke patients and controls were observed.
Favorova
O O
OO
Sudomoina
M A
MA
Martynov
M Iu
MIu
Serdiuk
I E
IE
Parfenov
M G
MG
Nikonova
A A
AA
Kolesnikova
T I
TI
Iasamanova
A N
AN
Gusev
E I
EI
D000483:Alleles; D002545:Brain Ischemia / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000235:genetics / Q000378:metabolism*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000502:physiology*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D012189:Retrospective Studies
C115499:BBeta fibrinogen; D005340:Fibrinogen; D004247:DNA