Copper-mediated coupling of 1,1-dibromo-1-alkenes with nitrogen nucleophiles: a general method for the synthesis of ynamides.
Mild reaction conditions are the advantage of the title reaction, which allows straightforward entry to a variety of ynamides starting from readily available 1,1-dibromo-1-alkenes, which act as attractive alkynylating agents (see scheme; EWG = electron-withdrawing group, DMF = N,N-dimethylformamide).
Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles Saint-Quentin en Yvelines, 45, avenue des Etats-Unis, 78035 Versailles Cedex, France.
Alexis
A
Coste
Ganesan
G
Karthikeyan
François
F
Couty
Gwilherm
G
Evano
D000475:Alkenes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*
D000475:Alkenes; D000577:Amides; D003300:Copper; D009584:Nitrogen