Estimation in longitudinal or panel data models with random-effect-based missing responses.
In studies with longitudinal or panel data, missing responses often depend on values of responses through a subject-level unobserved random effect. Besides the likelihood approach based on parametric models, there exists a semiparametric method, the approximate conditional model (ACM) approach, which relies on the availability of a summary statistic and a linear or polynomial approximation to some random effects. However, two important issues must be addressed in applying ACM. The first is how to find a summary statistic and the second is how to estimate the parameters in the original model using estimates of parameters in ACM. Our study is to address these two issues. For the first issue, we derive summary statistics under various situations. For the second issue, we propose to use a grouping method, instead of linear or polynomial approximation to random effects. Because the grouping method is a moment-based approach, the conditions we assumed in deriving summary statistics are weaker than the existing ones in the literature. When the derived summary statistic is continuous, we propose to use a classification tree method to obtain an approximate summary statistic for grouping. Some simulation results are presented to study the finite sample performance of the proposed method. An application is illustrated using data from the study of Modification of Diet in Renal Disease.
Eli Lilly and Company, Indianapolis, Indiana 46285, USA. xu_lei@lilly.com
Lei
L
Xu
Jun
J
Shao
D001699:Biometry / Q000379:methods*; D016001:Confidence Intervals; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000178:diet therapy / Q000503:physiopathology; D008137:Longitudinal Studies; D015233:Models, Statistical; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data