Breast cancer risk among Swedish hemangioma patients and possible consequences of radiation-induced genomic instability.
Breast cancer incidence among 17,158 female Swedish hemangioma patients was analyzed with empirical excess relative risk models and with a biologically-based model of carcinogenesis. The patients were treated in infancy mainly by external application of radium-226. The mean and median absorbed doses to the breast were 0.29 and 0.04Gy, and a total of 678 breast cancer cases have been observed. Both models agree very well in the risk estimates with an excess relative risk and excess absolute risk at the age of 50 years, about the mean age of breast cancer incidence, of 0.25Gy(-1)(95% CI 0.14; 0.37) and 30.7 (10(5) BYR Gy)(-1) (95% CI 16.9; 42.8), respectively. Models incorporating effects of radiation-induced genomic instability were developed and applied to the hemangioma cohort. The biologically-based description of the radiation risk was significantly improved with a model of genomic instability at an early stage of carcinogenesis.
Eidemüller
Markus
M
Helmholtz Zentrum München, Institute of Radiation Protection, Neuherberg, Germany. markus.eidemueller@helmholtz-muenchen.de
Holmberg
Erik
E
Jacob
Peter
P
Lundell
Marie
M
Karlsson
Per
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004273:DNA, Neoplasm / Q000528:radiation effects; D005260:Female; D005500:Follow-Up Studies; D042822:Genomic Instability / Q000528:radiation effects*; D006391:Hemangioma / Q000532:radiotherapy*; D006801:Humans; D015994:Incidence; D007223:Infant; D008875:Middle Aged; D008957:Models, Genetic; D009367:Neoplasm Staging; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology*; D011883:Radium / Q000009:adverse effects*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000532:radiotherapy*; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult
D004273:DNA, Neoplasm; D011883:Radium