Delayed oxaliplatin-induced sensorimotor polyneuropathy.
BACKGROUND
To date, only a few cases have been reported that indicate that a delayed polyneuropathy may occur after chemotherapy with oxaliplatin. The clinical and electrophysiological manifestations of this delayed neurotoxicity have never been well documented.


METHODS
Nerve conduction studies were performed in 4 patients who developed acute peripheral neuropathy several months after completion of oxaliplatin-containing chemotherapy. Sensory nerve conduction was abnormal in all patients. In 2 patients, the electrodiagnostic studies showed a mixed axonal and demyelinating sensorimotor polyneuropathy.


CONCLUSIONS
Delayed polyneuropathy occurring after oxaliplatin-based chemotherapy can be confirmed by electrophysiological studies.
Department of Neurology, Franz Tappeiner Hospital, Via Rossini 5, Meran (BZ), Italy. raffaele.nardone@asbmeran-o.it
Raffaele
R
Nardone
Thomas
T
Buratti
Stefan
S
Golaszewski
Arianna
A
Bratti
Francesca
F
Caleri
Frediano
F
Tezzon
Gunther
G
Ladurner
Manfred
M
Mitterer
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D005260:Female; D006801:Humans; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D011115:Polyneuropathies / Q000139:chemically induced* / Q000175:diagnosis*
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin