A retrospective review of glargine use in pregnancy.
OBJECTIVE
To review the obstetric outcome of 240 diabetic pregnancies maintained on basal glargine insulin.


METHODS
This is a retrospective review of the medical data from 240 pregnant diabetics who received glargine as a basal insulin. Perinatal outcome was abstracted from August 29, 2001, to December 31, 2007.


RESULTS
Mean maternal age was 33 years (SD +/- 5). Seventy-seven percent (184 of 240) of the women were diagnosed with gestational diabetes. The remaining 23% (56 of 240) had a diagnosis of type 2 diabetes. Weekly evaluation of each woman's daily 7x/d fingersticks yielded an individual mean capillary glucose value. These individual mean capillary glucose values were used to calculate a mean value for our sample population. This overall mean capillary glucose value for the 240 parturients was 112 +/- 14.8 mg/dL. The mean neonatal birth weight was 3,142 +/- 606 g. Only 4 neonates had birth weights > 4,000 g (4,365, 4,384, 4,535 and 4,624). None of the neonates were hypoglycemic.


CONCLUSIONS
Prenatal glargine appears to be well tolerated with acceptable perinatal outcome. For well-controlled pregestational diabetics, consideration should be given to continuing glargine during pregnancy.
Department of Obstetrics and Gynecology, Montefiore Medical Center North Division, 600 East 233 Street, 5th Floor, Bronx, NY 10466, USA. chenders@montefiore.org
Cassandra E
CE
Henderson
Surekha
S
Machupalli
Heynelda
H
Marcano-Vasquez
Patrick
P
Kerr
Kevin D
KD
Reilly
D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D002196:Capillaries; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy; D016640:Diabetes, Gestational / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting; D011247:Pregnancy; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics / Q000188:drug therapy; D012189:Retrospective Studies
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine