A radionuclide dosimetry toolkit based on material-specific Monte Carlo dose kernels.
OBJECTIVE
We sought to develop a user-friendly dosimetry toolkit that should aid the improvement of the quality of radionuclide therapy, which is critically dependent on patient-specific planning of each treatment.


METHODS
In this work, we present a new toolkit suitable for indicative radionuclide dose calculation. The software is built using open source tools and it uses dose kernels calculated using the Geant4 Application for Tomographic Emission simulation toolkit. In addition, a method that uses kernel data to extract a material-specific dose absorption factor is described and a proof of concept is given. In this work, time dependency and organ sensitivity are not modeled.


RESULTS
The developed software utilizes Monte Carlo calculated dose kernels and proposes a fast dose calculation method. Using computed tomography or magnetic resonance imaging it can provide a more accurate and personalized indicative dose map.


CONCLUSIONS
Dosimetry based on quantitative three-dimensional data is more accurate and allows a more individualized approach in patient therapy. Moreover, the use of this toolkit with the standardization for data collection and processing will increase the accuracy as well as the compatibility of radiation dose.
Loudos
George
G
Department of Medical Instruments Technology, Technological Educational Institute of Athens, Greece. gloudos@teiath.gr
Tsougos
Ioannis
I
Boukis
Spyros
S
Karakatsanis
Nikolas
N
Georgoulias
Panagiotis
P
Theodorou
Kiki
K
Nikita
Konstantina
K
Kappas
Constantin
C
D001842:Bone and Bones / Q000528:radiation effects; D009010:Monte Carlo Method; D049268:Positron-Emission Tomography; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D012984:Software; D014057:Tomography, X-Ray Computed; D014584:User-Computer Interface; D014867:Water
D014867:Water