Whole-body 18FDG PET-CT imaging of systemic sarcoidosis: ophthalmic oncology and uveitis.
OBJECTIVE
To describe whole-body 18-fluorodeoxyglucose (FDG) positron emission tomography/computed radiographic tomography (PET-CT) imaging of ophthalmic patients with systemic sarcoidosis.


METHODS
Four systemic sarcoidosis patients were evaluated with PET-CT for staging. Two had been treated for conjunctival melanoma and two had been referred for atypical choroidal tumors. PET-CT images were studied for presence of tumor or tissue with increased standardized uptake values, indicating increased metabolic activity.


RESULTS
In all cases, PET-CT revealed focal systemic lesions with increased uptake (SUV range 1.7-5.9 kg/mL). Cases 1 and 2 had a previous diagnosis of sarcoidosis (without ocular involvement), while cases 3 and 4 were diagnosed during their work-up. PET-CT revealed the presence and distribution of systemic sarcoid granulomas.


CONCLUSIONS
In this series, PET-CT staged patients with eye cancer and systemic sarcoidosis and aided in differentiating between a metastatic choroidal tumor and uveal sarcoid granuloma. PET-CT offers a method to assess the presence and distribution of systemic sarcoidosis.
The New York Eye Cancer Center, New York, New York 10065, USA.
Julia P
JP
Shulman
Paul
P
Latkany
Kimberly J
KJ
Chin
Paul T
PT
Finger
D002830:Choroid Neoplasms / Q000150:complications / Q000175:diagnosis / Q000556:secondary; D003230:Conjunctival Neoplasms / Q000150:complications / Q000175:diagnosis / Q000556:secondary; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000556:secondary; D005260:Female; D019788:Fluorodeoxyglucose F18; D006099:Granuloma / Q000175:diagnosis; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications / Q000175:diagnosis / Q000556:secondary; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D014603:Uveal Diseases / Q000175:diagnosis; D014605:Uveitis / Q000150:complications / Q000175:diagnosis*; D055815:Young Adult
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18