Retroactive interference in normal aging: a magnetoencephalography study.
Biomagnetic responses were recorded from healthy elderly subjects (55-67 years) performing a working memory task during recognition. The objective was to identify differential spatio-temporal brain activity patterns with magnetoencephalography by the presentation of two types of retroactive interference, active and passive. We obtained increased activity in the left medial temporal lobe and the left anterior ventral prefrontal cortex at early (100-200 ms) and medium latencies (300-400 ms) for the active interference group, and left anterior ventral prefrontal cortex showed greater activity at late latencies (700-800 ms) for the passive interference group. A time-modulated ventral prefrontal activation was shown for the active and passive interference conditions indicating that executive control mechanisms were necessary in both groups.
Centro de Magnetoencefalografía Dr. Pérez Modrego, Universidad Complutense de Madrid, Av. Complutense S/N, Pabellón 8, Medicina, Ciudad Universitaria, 28040, Madrid, Spain. esolesio@psi.ucm.es
Elena
E
Solesio
Laura
L
Lorenzo-López
Pablo
P
Campo
José María
JM
López-Frutos
José María
JM
Ruiz-Vargas
Fernando
F
Maestú
D000368:Aged; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged