Optimizing cerebral glucose in severe traumatic brain injury: still some way to go.
This commentary considers some of the factors that affect cerebral glucose metabolism in patients with traumatic brain injury. A study recently reported in Critical Care suggested a blood glucose range that may optimize cerebral glucose utilization; the findings of this study are evaluated and discussed. Some of the mechanisms of cerebral glucose control are explored, including the impact of intensive insulin therapy on cerebral metabolism.
Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ, UK.
Cameron
C
Zahed
Arun K
AK
Gupta
D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism / Q000503:physiopathology*; D003422:Critical Care / Q000379:methods; D051246:Glucose Transport Proteins, Facilitative; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D015599:Trauma Severity Indices
D001786:Blood Glucose; D051246:Glucose Transport Proteins, Facilitative; D007328:Insulin