Association of prior stroke with cognitive function and cognitive impairment: a population-based study.
BACKGROUND
Defining the nature of the contribution of stroke to cognitive impairment remains challenging.


OBJECTIVE
To describe associations between stroke history, APOE genotype, and subtypes of mild cognitive impairment (MCI).


METHODS
We randomly selected residents from Olmsted County, Minnesota, aged 70 to 89 years on October 1, 2004, and invited eligible subjects without documented dementia to participate. Participants (n = 2050) were evaluated through an informant interview, a neurological evaluation, and neuropsychological testing. Neuropsychological testing included 9 tests to assess memory, attention, executive function, visuospatial cognition, and language. Subjects were diagnosed by consensus as cognitively normal or as having MCI (either amnestic or nonamnestic) or dementia. A history of stroke was obtained from the subjects and confirmed in their medical records. We computed the odds ratios (ORs) for a clinical diagnosis of MCI or for scoring in the lowest quartile on each cognitive domain.


RESULTS
There were 1640 cognitively normal subjects and 329 subjects with MCI: 241 with amnestic MCI and 88 with nonamnestic MCI. In fully adjusted models with only subjects without dementia, a history of stroke was associated with a higher OR of nonamnestic MCI (OR, 2.85; 95% confidence interval [CI], 1.61-5.04) than amnestic MCI (OR, 1.77; 95% CI, 1.14-2.74). A history of stroke was also associated with impaired function in each cognitive domain except memory. The association was strongest for attention and executive function (OR, 2.48; 95% CI, 1.73-3.53). APOE epsilon4 genotype was associated only with amnestic MCI and with impaired memory function.


CONCLUSIONS
In this population-based sample of persons without dementia, a history of stroke was particularly associated with nonamnestic MCI and impairment in nonmemory cognition. The APOE epsilon4 genotype was associated with memory impairment and amnestic MCI.
Knopman
David S
DS
Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA. knopman@mayo.edu
Roberts
Rosebud O
RO
Geda
Yonas E
YE
Boeve
Bradley F
BF
Pankratz
V Shane
VS
Cha
Ruth H
RH
Tangalos
Eric G
EG
Ivnik
Robert J
RJ
Petersen
Ronald C
RC
D000368:Aged; D000369:Aged, 80 and over; D053327:Apolipoprotein E4 / Q000235:genetics; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D003704:Dementia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D009483:Neuropsychological Tests; D020521:Stroke / Q000150:complications* / Q000523:psychology
D053327:Apolipoprotein E4; D005819:Genetic Markers