Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors.
Second malignancies occur in 2-3% of survivors of pediatric osteosarcoma; treatment-related hematologic and solid malignancies have both been described. We present two cases of patients with pulmonary nodules that developed more than 2 years after treatment of osteosarcoma. Both lesions were completely resected and pathology revealed bronchioloalveolar carcinoma (BAC). Primary BAC is extremely rare in children; however, cases of this malignancy have been described in survivors of pediatric cancer. BAC may present as a solitary pulmonary nodule indistinguishable from a metastatic lesion and should be included in the differential diagnosis of pulmonary nodules in survivors of pediatric cancer.
Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. jeffreylebensburger@stjude.org
Jeffrey
J
Lebensburger
Howard
H
Katzenstein
Jesse J
JJ
Jenkins
Carlos
C
Rodriguez-Galindo
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000209:etiology* / Q000473:pathology; D001859:Bone Neoplasms / Q000628:therapy*; D002648:Child; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology*; D012516:Osteosarcoma / Q000628:therapy*; D017741:Survivors