Conjunctival melanomas: can the cancer stem cell hypothesis be applied?
Conjunctival melanoma patients often follow an unpredictable course with significant rates of recurrence and metastases despite optimal treatment. Can we better understand conjunctival melanomas by applying the cancer stem cell hypothesis? The cancer stem cell hypothesis posits that cancers exist as a hierarchical system where cancer stem cells generate and maintain tumors. Targeting cancer stem cells may be the key to future treatments. Directed treatments need to focus on key differences between cancer stem cells and normal tissue stem cells. These directed treatments may lead to curative therapies and decrease the number of recurrences and metastases.
Ciralsky
Jessica
J
Cornea Department, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St., Boston, MA 02114, USA. Jessica.Ciralsky@meei.harvard.edu
Colby
Kathryn
K
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003230:Conjunctival Neoplasms / Q000098:blood supply / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008545:Melanoma / Q000098:blood supply / Q000209:etiology* / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000188:drug therapy
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents