[Haematological adverse effects caused by psychiatric drugs].
Almost all clases of psychiatric drugs (typical and atypical antipsychotics, antidepressants, mood stabilizers, benzodiazepines) have been reported as possible causes of haematological toxicity. This is a review of the literature in which different clinical situations involving red blood cells, white blood cells, platelets and impaired coagulation are detailed and the drugs more frequently involved are listed. The haematological adverse reactions detailed here include: aplastic anemia, haemolitic anemia, leukopenia, agranulocytosis, leukocytosis, eosinophilia, thrombocytosis, thrombocytopenia, disordered platelet function and impaired coagulation. The haematologic toxicity profile of the drugs more frequently involved: lithium, clozapine, carbamazepine, valproic acid and SSRI antidepressants is mentioned.
Mazaira
Silvina
S
Primera Cátedra de Farmacología de la Facultad de Medicina, Universidad de Buenos Aires, Argentina. smazaira@arnet.com.ar
D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001792:Blood Platelets; D004912:Erythrocytes; D006402:Hematologic Diseases / Q000139:chemically induced*; D006801:Humans; D007962:Leukocytes; D011619:Psychotropic Drugs / Q000009:adverse effects*
D011619:Psychotropic Drugs