Cartilage cell proliferation in degenerative TFCC wrist lesions.
BACKGROUND
The central zone of the triangular fibrocartilage complex (TFCC) of the wrist is thought to be avascular and is generally considered to lack any healing potential.


OBJECTIVE
The purpose of this study was to investigate, if cartilage cells of degenerative disc lesions possess any healing or proliferation potential and whether ulna length plays a significant role in the proliferation process.


RESULTS
Cells positive for proliferating cell nuclear antigen (PCNA) were found in all specimens. Specimens of patients with ulna positive variance showed a decreased number of PCNA positive cells than specimens of patients with either negative or neutral ulna variance.


CONCLUSIONS
We found that cartilage cells of Palmer type 2C lesions undergo mitotic cell division, thus exhibiting proliferation capability. It could not be shown that ulnar length is significantly correlated with the number of PCNA positive cells.
Department of Plastic and Hand Surgery, University Erlangen, Germany. Frank.Unglaub@uk-erlangen.de
Frank
F
Unglaub
Susanne B
SB
Thomas
Maya B
MB
Wolf
Adrian
A
Dragu
Markus W
MW
Kroeber
Thomas
T
Mittlmeier
Raymund E
RE
Horch
D000328:Adult; D001182:Arthroscopy; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008938:Mitosis; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012038:Regeneration / Q000502:physiology; D051478:Triangular Fibrocartilage / Q000166:cytology* / Q000254:growth & development / Q000293:injuries* / Q000378:metabolism; D014954:Wrist Injuries / Q000473:pathology
D018809:Proliferating Cell Nuclear Antigen