Effects of a minimum interval immunization schedule for diphtheria and tetanus toxoids and acellular pertussis vaccination during a pertussis outbreak.
OBJECTIVE
To examine the impact of a minimum interval schedule for administering diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP) in infants during a statewide pertussis outbreak on receipt of inactivated polio vaccine (IPV) and pneumococcal conjugate vaccine (PCV).


METHODS
Retrospective cohort study using the state immunization registry.


METHODS
Arizona.


METHODS
Arizona children born between February 1 and September 30, 2005, who received their initial DTaP dose during a statewide pertussis outbreak (N = 45 129). Main Exposures Children who received at least 1 dose of DTaP on the minimum interval schedule (minimum interval group) compared with children who received all doses of DTaP on the standard childhood and adolescent immunization schedule (standard group).


METHODS
Timing and receipt of 3 doses of the DTaP, IPV, and PCV.


RESULTS
Compared with children in the standard group, children in the minimum interval group were more likely to receive 3 doses of DTaP (relative risk, 1.34; 95% confidence interval, 1.32-1.35), 3 doses of IPV (1.27; 1.25-1.29), and 3 doses of PCV (1.37; 1.35-1.39).


CONCLUSIONS
Recommending a minimum interval DTaP schedule during a statewide pertussis outbreak had a positive association with the receipt of IPV and PCV, 2 vaccines normally administered at the same time as DTaP.
Arizona Department of Health Services, Phoenix, AZ 85007, USA.
Daniel
D
Bronson-Lowe
Shoana M
SM
Anderson
D001130:Arizona; D015331:Cohort Studies; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage*; D004196:Disease Outbreaks; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage; D012189:Retrospective Studies; D014917:Whooping Cough / Q000453:epidemiology*
D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D022242:Pneumococcal Vaccines; D011054:Poliovirus Vaccine, Inactivated