Bone disease in patients with primary hypercalciuria and calcium nephrolithiasis.
In patients affected by calcium nephrolithiasis, primary hypercalciuria is frequently accompanied by bone demineralisation and increased susceptibility to fragility fractures. The relationship between bone loss and primary hypercalciuria is multifactorial. Organs and tissues which control calcium and phosphate metabolism - bone, intestine, and kidney - are actively involved in the pathogenesis of bone alterations which together form a multi-factorial metabolic disorder. We conducted a comprehensive evaluation of the published data concerning hypercalciuria and nephrolithiasis included in Medline from 1985 and 2005.
Tasca
Andrea
A
Department of Surgery, Division of Urology, San Bortolo Hospital, Vicenza, Italy. andrea.tasca@ulssvicenza.it
Dalle Carbonare
Luca
L
Nigro
Filippo
F
Giannini
Sandro
S
D001847:Bone Diseases / Q000209:etiology*; D002118:Calcium / Q000032:analysis; D006801:Humans; D053565:Hypercalciuria / Q000150:complications* / Q000503:physiopathology; D053040:Nephrolithiasis / Q000150:complications*
D002118:Calcium