Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks  of gastritis and reverse gastric lesions in rats.
In this study we investigated the effects of Gardenia jasminoides Ellis (GJE) extract and its constituents, such as ursolic acid and genipin, on gastritis in rats and the growth of human gastric cancer cells. The GJE extract, ursolic acid and genipin showed the acid-neutralizing capacities, the antioxidant activities, and the inhibitory effects on the growth of Helicobacter pylori (H. pylori), which are almost equivalent to positive control compounds. In addition, the GJE extract and ursolic acid had cytotoxic activity against AGS and SUN638 gastric cancer cells. The genipin and ursolic acid inhibited significant HCl/ethanol-induced gastric lesions. Taken together, GJE extract and its constituents might have antigastritic activities, associated with the antioxidant activities, acid-neutralizing capacities, and anti-H. pylori action. Also, we could suggest that genipin and ursolic acid may be useful for the treatment and/or protection of gastritis.
Plant Resources Research Institute, Duksung Women's University, Seoul 132-714, Republic of Korea.
Je-Hyuk
JH
Lee
Dong-Ung
DU
Lee
Choon-Sik
CS
Jeong
D000818:Animals; D000897:Anti-Ulcer Agents; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D045744:Cell Line, Tumor; D000431:Ethanol; D016166:Free Radical Scavengers / Q000494:pharmacology; D032062:Gardenia / Q000737:chemistry*; D005756:Gastritis / Q000139:chemically induced / Q000517:prevention & control*; D016481:Helicobacter Infections / Q000188:drug therapy / Q000382:microbiology; D016480:Helicobacter pylori; D007202:Indicators and Reagents; D057889:Iridoid Glycosides; D039823:Iridoids / Q000302:isolation & purification / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents; D013274:Stomach Neoplasms / Q000473:pathology / Q000517:prevention & control; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology; D000097245:Ursolic Acid
D000897:Anti-Ulcer Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D000431:Ethanol; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D057889:Iridoid Glycosides; D039823:Iridoids; D010936:Plant Extracts; D012997:Solvents; D014315:Triterpenes; D000097245:Ursolic Acid; C007834:genipin