Emergence of quinolone-resistant Bordetella pertussis in Japan.
Six Bordetella pertussis strains isolated from children in Japan from 2004 to 2006 showed high-level resistance to nalidixic acid (NAL; MIC, >256 microg/ml) and decreased susceptibilities to fluoroquinolones. All of the NAL-resistant strains had the same D87G mutation in gyrA.
Ohtsuka
Masayuki
M
Department of Infection Control Science, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan. kikuti@juntendo.ac.jp
Kikuchi
Ken
K
Shimizu
Kenichiro
K
Takahashi
Namiko
N
Ono
Yuka
Y
Sasaki
Takashi
T
Hiramatsu
Keiichi
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001886:Bordetella pertussis / Q000187:drug effects* / Q000235:genetics*; D002648:Child; D027081:DNA Gyrase / Q000235:genetics; D024841:Fluoroquinolones / Q000494:pharmacology; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009268:Nalidixic Acid / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D015363:Quinolones; D009268:Nalidixic Acid; D027081:DNA Gyrase