Oxidative damage of the extracts of condensate, particulate and semivolatile organic compounds from gasoline engine exhausts on testicles of rats.
Oxidative damage induced by extracts of condensate, particulate matters and semivolatile organic compounds from gasoline engine exhausts were investigated in testicles of adult Sprague-Dawley rats. The results showed that gasoline engine exhaust could increase the contents of malondialdehyde and carbonyl protein, decrease activities of superoxide dismutase and glutathione peroxidase, and induce DNA damage in testicle of rat. Taking together, the gasoline engine exhaust could promote oxidative damage of bio-macromolecular in testicles of rat and oxidative stress might be an alternative mechanism for male reproductive function of male mammals.
Kunming Center for Disease Control and Prevention, No. 4 Ziyun Road, Kunming, China.
Wangjun
W
Che
Hong
H
Qiu
Guiming
G
Liu
Yun
Y
Ran
Hao
H
Zhang
Li
L
Zhang
Weihua
W
Wen
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D053904:DNA Breaks, Single-Stranded / Q000187:drug effects; D005742:Gasoline / Q000633:toxicity; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009152:Mutagenicity Tests; D018384:Oxidative Stress / Q000187:drug effects; D052638:Particulate Matter / Q000633:toxicity*; D050050:Protein Carbonylation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D001335:Vehicle Emissions / Q000633:toxicity*; D055549:Volatile Organic Compounds / Q000633:toxicity*
D015415:Biomarkers; D005742:Gasoline; D052638:Particulate Matter; D001335:Vehicle Emissions; D055549:Volatile Organic Compounds; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase