Neurochemistry underlying relapse to opiate seeking behaviour.
Relapse is a major clinical problem and remains a major challenge in the treatment of addictions. A goal of current research is to gain a greater understanding of the neurochemistry underlying relapse to opiate use. Factors which trigger relapse in humans such as stress, exposure to opiates and/or drug-associated cues, can also trigger opiate-seeking in animals. This review will overview preclinical studies relating to the neurochemistry of opiate-seeking with a focus on studies published from 2005 to present.
Brown
Robyn M
RM
Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia.
Lawrence
Andrew J
AJ
D000818:Animals; D016739:Behavior, Addictive / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control*; D001923:Brain Chemistry / Q000502:physiology*; D006801:Humans; D009293:Opioid-Related Disorders / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control*; D055502:Secondary Prevention