Carbon monoxide: vascular therapeutic for the future.
In the past decade, carbon monoxide has lost its reputation as a toxic gas and has gained a following of scientists who now appreciate its potential therapeutic utility as an anti-inflammatory and cytoprotective agent. Its vasoprotective properties have also gained a tremendous amount of attention, especially its ability to inhibit intimal hyperplasia. This review will provide a historical perspective of carbon monoxide biology and summarize its function in disease modulation with a special focus on its potential role as a vascular therapeutic.
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA. tzenge@upmc.edu
Edith
E
Tzeng
D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism / Q000627:therapeutic use*; D002404:Catheterization / Q000009:adverse effects*; D005544:Forecasting; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia / Q000517:prevention & control; D023421:Models, Animal; D017539:Tunica Intima / Q000378:metabolism / Q000473:pathology*
D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing)