Contributions of neuroimaging, balance testing, electrophysiology and blood markers to the assessment of sport-related concussion.
OBJECTIVE
To review the diagnostic tests and investigations used in the management of sports concussion, in the adult and paediatric populations, to (a) monitor the severity of symptoms and deficits, (b) track recovery and (c) advance knowledge relating to the natural history and neurobiology of the injury.


METHODS
Qualitative literature review of the neuroimaging, balance testing, electrophysiology, blood marker and concussion literature.


METHODS
PubMed and Medline databases were reviewed for investigations used in the management of adult and paediatric concussion, including structural imaging (computerised tomography, magnetic resonance imaging, diffusion tensor imaging), functional imaging (single photon emission computerised tomography, positron emission tomography, functional magnetic resonance imaging), spectroscopy (magnetic resonance spectroscopy, near infrared spectroscopy), balance testing (Balance Error Scoring System, Sensory Organization Test, gait testing, virtual reality), electrophysiological tests (electroencephalography, evoked potentials, event related potentials, magnetoencephalography, heart rate variability), genetics (apolipoprotein E4, channelopathies) and blood markers (S100, neuron-specific enolase, cleaved Tau protein, glutamate).


RESULTS
For the adult and paediatric populations, each test has been classified as being: (1) clinically useful, (2) a research tool only or (3) not useful in sports-related concussion.


CONCLUSIONS
The current status of the diagnostic tests and investigations is analysed, and potential directions for future research are provided. Currently, all tests and investigations, with the exception of clinical balance testing, remain experimental. There is accumulating research, however, that shows promise for the future clinical application of functional magnetic resonance imaging in sport concussion assessment and management.
Department of Neurosurgery, Cabrini Hospital and Austin Hospital, Melbourne, Victoria, Australia. gadavis@netspace.net.au
G A
GA
Davis
G L
GL
Iverson
K M
KM
Guskiewicz
A
A
Ptito
K M
KM
Johnston
D000293:Adolescent; D000328:Adult; D001265:Athletic Injuries / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D001924:Brain Concussion / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D003952:Diagnostic Imaging / Q000379:methods*; D003943:Diagnostic Techniques, Neurological; D055724:Electrophysiological Phenomena / Q000502:physiology; D005544:Forecasting; D020233:Gait Disorders, Neurologic / Q000175:diagnosis; D005819:Genetic Markers; D006801:Humans; D004856:Postural Balance
D015415:Biomarkers; D005819:Genetic Markers