Aqueous synthesis of type-II CdTe/CdSe core-shell quantum dots for fluorescent probe labeling tumor cells.
In this paper, we report a two-step aqueous synthesis of highly luminescent CdTe/CdSe core/shell quantum dots (QDs) via a simple method. The emission range of the CdTe/CdSe QDs can be tuned from 510 to 640 nm by controlling the thickness of the CdSe shell. Accordingly, the photoluminescence quantum yield (PL QY) of CdTe/CdSe QDs with an optimized thickness of the CdSe shell can reach up to 40%. The structures and compositions of the core/shell QDs were characterized by transmission electron microscopy, x-ray diffraction, and x-ray photoelectron spectroscopy experiments, and their formation mechanism is discussed. Furthermore, folate conjugated CdTe/CdSe QDs in Hela cells were assessed with a fluorescence microscope. The results show that folate conjugated CdTe/CdSe QDs could enter tumor cells efficiently.
State Key Lab of CSBC, and Micro-Nano Center, Hunan University, Changsha, PR China.
Ruosheng
R
Zeng
Tingting
T
Zhang
Jincheng
J
Liu
Song
S
Hu
Qiang
Q
Wan
Xuanming
X
Liu
Zhiwei
Z
Peng
Bingsuo
B
Zou
D019187:Cadmium Compounds / Q000737:chemistry*; D003102:Colloids / Q000737:chemistry; D003287:Contrast Media; D003460:Crystallization / Q000379:methods; D006367:HeLa Cells; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008856:Microscopy, Fluorescence / Q000379:methods*; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry*; D013194:Staining and Labeling / Q000379:methods; D013499:Surface Properties; D013691:Tellurium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D019187:Cadmium Compounds; D003102:Colloids; D003287:Contrast Media; D046911:Macromolecular Substances; D018036:Selenium Compounds; D014867:Water; C058667:cadmium selenide; D013691:Tellurium; C028337:cadmium telluride