The influence of lovastatin on thrombomodulin gene expression in vascular endothelial cells--in vitro study.
OBJECTIVE
Statins reduce lipids concentration in blood. The latest investigations show they also improved the function of vascular endothelial cells (ECs). Thrombomodulin (TM) is particularly important marker of ECs activity. We investigated the in vitro effect of lovastatin on the expression level of TM gene.


RESULTS
ECs were incubated for 24 h in culture medium including lovastatin in 3 concentrations: 0.1, 1.0, 10.0 mol/l. The mRNA level of TM increased in correlation with rising concentrations of lovastatin to 600 % vs. control group.


CONCLUSIONS
TM is essential antithrombotic factor in endothelial cells. Lovastatin significantly raises thrombomodulin gene expression. It is important characteristics of this medicine, which prevents cardiovascular events.
Depatment of Pathophysiology, Nicolaus Copernicus University, Collegium Medicum, Toruń, Bydgoszcz, Poland. krzyg@cm.umk.pl
Krzysztof
K
Góralczyk
Krystyna
K
Soszyńska
Olga
O
Haus
Robert
R
Bielis
Danuta
D
Rość
D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D008148:Lovastatin / Q000494:pharmacology*; D018180:Thrombomodulin / Q000235:genetics* / Q000378:metabolism
D018180:Thrombomodulin; D008148:Lovastatin