[Functional activity of peritonal macrophages in liver immune damage of cellular and antibody genesis in mice].
The aim of present work was to compare the functional activity of peritoneal macrophages (Mf) at T-cellular and antibody induced hepatitis in mice of CBA line. T-cellular hepatitis was caused by concanavalin A (ConA), antibody-induced hepatitis was caused by administration of xenogenic anti-liver antibodies: gamma-globulin fractions of antihepatocytotoxic serum (gamma-AHCS). It was found that single injection of ConA or gamma-AHCS caused damage of liver with cytolytic syndrome through 20 hours. Functional activity of Mf in these conditions was significantly different. Application of ConA resulted in the decrease in phagocytosis of latex particles and oxygen-dependent metabolism; application of gamma-AHCS--to increase of these processes. Weakening of Mf activity may be one of the reasons for the decrease of dead cell eliminations that results in the maintenance of inflammatory reaction. At the same time significant amplification of phagocytic Mf activity may be one of the pathways of free radical endogenic sources increase that causes cell alteration and plays its role as mediators at inflammation.
Martynova
T V
TV
Aleksieieva
I M
IM
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D004195:Disease Models, Animal; D019693:Hepatitis, Autoimmune / Q000276:immunology*; D007128:Immunoglobulin Fragments / Q000276:immunology; D008099:Liver / Q000187:drug effects* / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000276:immunology / Q000502:physiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology
D000911:Antibodies, Monoclonal; D007128:Immunoglobulin Fragments; D005719:gamma-Globulins; D003208:Concanavalin A