Mechanisms of transplantation tolerance in animals and humans.
Donor-specific immune tolerance would avoid the toxicities of chronic immunosuppressive therapies while preventing graft rejection. Hematopoietic cell transplantation has shown preliminary success for intentional tolerance induction in pilot clinical trials. The mechanisms of tolerance in these trials and the animal studies leading up to them are discussed.
Sykes
Megan
M
Bone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA. megan.sykes@tbrc.mgh.harvard.edu
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes; D006086:Graft vs Host Disease / Q000276:immunology; D019337:Hematologic Neoplasms / Q000276:immunology; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016131:Lymphocyte Subsets / Q000276:immunology; D051379:Mice; D023421:Models, Animal; D010865:Pilot Projects; D013601:T-Lymphocytes / Q000276:immunology; D018183:Transplantation Chimera; D023001:Transplantation Tolerance / Q000276:immunology* / Q000502:physiology; D014184:Transplantation, Homologous / Q000276:immunology