Bone tumors: osteosarcoma and Ewing's sarcoma.
OBJECTIVE
Osteosarcoma and Ewing's sarcoma are the two most common primary malignant bone tumors in children and account for approximately 6% of all childhood malignancies. Treatment methods have seen significant advancements, particularly in regard to chemotherapy and limb-sparing surgery. These advancements have led to increased survival rate. With many long-term survivors, it is important to evaluate long-term patient outcomes following treatment, including function and health-related quality of life. We will review the current trends in treatment of these diseases, different reconstructive options available, and the methods and results for evaluating the long-term results.


RESULTS
There have been many improvements in the medical treatment of these tumors leading to increasing long-term survival. There have also been improvements in reconstructive techniques for the maintenance of functional extremities in these patients. Newer evaluation methods for both functional outcome and health-related quality of life measures that are more specific to children and adolescents are being developed and in use.


CONCLUSIONS
This report will provide an overview of the current treatment options and long-term complications in primary malignant bone tumors for the pediatrician caring for a child with these problems.
Musculoskeletal Tumor Program, Department of Orthopaedic Surgery, University of Colorado, The Children's Hospital, Denver, CO, USA. heare.travis@tchden.org
Travis
T
Heare
Mary A
MA
Hensley
Shelley
S
Dell'Orfano
D000293:Adolescent; D001859:Bone Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D009017:Morbidity; D009367:Neoplasm Staging / Q000379:methods; D012516:Osteosarcoma / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D014481:United States / Q000453:epidemiology