[Triptans versus other migraine medicine--secondary publication].
The introduction of triptans in the treatment of migraine was apparently a revolution.Comparative randomised trials do not, however, show a clearcut picture.Oral triptans outperform oral ergotamine most because of the extremely low (< 1%) oral bioavailability of ergotamine. Compared with NSAIDs, triptants are not, in most cases, superior to aspirin. Aspirin is suggested as first-choice drug in migraine treatment. An additional advantage of aspirin is that is it much less expensive than triptans.
Dansk Hovedpinecenter, Neurologisk Afdeling, Glostrup Hospital. ptha@glo.regionh.dk
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Tfelt-Hansen
D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage; D016896:Treatment Outcome; D014363:Tryptamines / Q000008:administration & dosage*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; D014662:Vasoconstrictor Agents; D001241:Aspirin