Recent findings on the organization of central nervous system structures involved in the innervation of endocrine glands and other organs; observations obtained by the transneuronal viral double-labeling technique.
This review summarizes the data obtained with the aid of the recently introduced dual viral tracing technique, which uses isogenic recombinants of pseudorabies virus that express unique reporter gene. This approach made possible to explore simultaneously neural circuits of two organs. The results of these studies indicate: (1) there are neurons innervating exclusively a given organ; (2) left-sided predominance in the supraspinal innervation of the endocrine glands (adrenal, ovary) studied, so far; (3) viral co-infection of neurons, i.e., special neuronal populations coexist in different brain areas that are transsynaptically connected with both paired endocrine and non-endocrine organs, endocrine glands and non-endocrine organs, and organs of bodily systems other than the endocrine one. The number of common neurons seems to be related to the need of coordinating action of different systems. The data on co-infection of neurons suggest that the central nervous system has the capacity to coordinate different organ functions via common brain neurons providing supraspinal innervation of the organs.
Gerendai
Ida
I
Neuromorphological and Neuroendocrine Research Laboratory, Department of Human Morphology and Developmental Biology, Hungarian Academy of Sciences and Semmelweis University, Tuzoltó u. 58, 1094, Budapest, Hungary. gerendai@ana2.sote.hu
Tóth
Ida E
IE
Boldogkoi
Zsolt
Z
Halász
Béla
B
D000825:Animal Structures / Q000294:innervation* / Q000378:metabolism; D000818:Animals; D002490:Central Nervous System / Q000033:anatomy & histology* / Q000502:physiology; D004702:Endocrine Glands / Q000294:innervation* / Q000378:metabolism; D011558:Herpesvirus 1, Suid / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009415:Nerve Net / Q000378:metabolism / Q000502:physiology / Q000821:virology; D030781:Organisms, Genetically Modified; D013194:Staining and Labeling / Q000379:methods*