Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics.
To investigate the possible origin and spread of the dramatic re-emergent 2002 distemper epizootic observed among seals in Danish Waters, we have sequenced wild-type genes of the attachment (H) glycoproteins of viruses from both the 2002 and 1988 epizootics. Phylogenetic analysis of the H genes of phocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002 PDV is more closely related to a putative recent ancestral PDV than the 1988 PDV isolates. Moreover, upsurges of distemper disease in land-living carnivores linked in time and locality to the 2002 seal epizootic in Danish Waters was investigated and determined to be caused by canine distemper virus, the closest relative of PDV, revealing no direct epidemiological link to the seal epizootics.
Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Stigbøjlen 7, 1870 Frederiksberg C, Denmark.
Line
L
Nielsen
Peter
P
Arctander
Trine H
TH
Jensen
Hans-Henrik
HH
Dietz
Anne S
AS
Hammer
Ashley C
AC
Banyard
Thomas
T
Barrett
Merete
M
Blixenkrone-Møller
D000595:Amino Acid Sequence; D000818:Animals; D016000:Cluster Analysis; D003718:Denmark / Q000453:epidemiology; D004216:Distemper / Q000453:epidemiology* / Q000821:virology; D018104:Distemper Virus, Phocine / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D014644:Genetic Variation; D008969:Molecular Sequence Data; D046049:Phoca; D010802:Phylogeny; D046048:Seals, Earless; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D015678:Viral Structural Proteins / Q000235:genetics*
D015678:Viral Structural Proteins