3 case reports of edema associated with quetiapine.
BACKGROUND
Edema associated with quetiapine has been described in only one case report to date and represents a potentially serious adverse reaction.


METHODS
We present a case series of 3 patients who developed bilateral leg edema following initiation of quetiapine.


RESULTS
One of these patients had a recurrence of edema with subsequent rechallenge. Another patient developed quetiapine-induced edema following a prior episode of olanzapine-induced edema. All 3 cases present a compelling temporal relationship between the drug challenge and the adverse event.


CONCLUSIONS
Prompt recognition and intervention with discontinuation of the offending agent is important for this potentially serious, seemingly idiosyncratic vascular complication.
Koleva
Hristina K
HK
Department of Psychiatry, The University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242-1009, USA. hristina-koleva@uiowa.edu
Erickson
Mark A
MA
Vanderlip
Erik R
ER
Tansey
Janeta
J
Mac
Joseph
J
Fiedorowicz
Jess G
JG
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology*; D003863:Depression / Q000188:drug therapy* / Q000523:psychology*; D003987:Dibenzothiazepines / Q000009:adverse effects*; D004334:Drug Administration Schedule; D004487:Edema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000523:psychology; D000069348:Quetiapine Fumarate; D013406:Suicide, Attempted / Q000523:psychology
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate