Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp.
In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an IC50 value of 22.4 microM without cytotoxicity.
Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.
Soo-Jin
SJ
Choo
Bong-Sik
BS
Yun
In-Ja
IJ
Ryoo
Young-Hee
YH
Kim
Ki-Hwan
KH
Bae
Ick-Dong
ID
Yoo
D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D002461:Cell Line, Transformed; D002470:Cell Survival / Q000187:drug effects; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D013058:Mass Spectrometry; D008543:Melanins / Q000037:antagonists & inhibitors / Q000378:metabolism; D008544:Melanocytes / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular
D003572:Cytochalasins; D008543:Melanins; C484204:aspochalasin I; D014442:Monophenol Monooxygenase