Prevalence and molecular diversity of hepatitis B virus and hepatitis delta virus in urban and rural populations in northern Gabon in central Africa.
The prevalence of hepatitis B virus (HBV) surface antigen was significantly higher in urban (12.9%) than in rural (7.6%) populations (P = 0.003), but no difference was found in the prevalence of hepatitis delta virus (HDV), which was high in both populations. Phylogenetic analysis showed the circulation of HBV-A3 and -E genotypes and the presence of HDV-1, HDV-7, and HDV-8 clades.
Unité de Virologie, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon.
Maria
M
Makuwa
Armel
A
Mintsa-Ndong
Sandrine
S
Souquière
Dieudonné
D
Nkoghé
Eric M
EM
Leroy
Mirdad
M
Kazanji
D000293:Adolescent; D000328:Adult; D000350:Africa, Central / Q000453:epidemiology; D000368:Aged; D000369:Aged, 80 and over; D016000:Cluster Analysis; D005260:Female; D005681:Gabon / Q000453:epidemiology; D006509:Hepatitis B / Q000453:epidemiology* / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D003699:Hepatitis D / Q000453:epidemiology* / Q000821:virology; D003698:Hepatitis Delta Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D011110:Polymorphism, Genetic; D015995:Prevalence; D012424:Rural Population; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014505:Urban Population; D055815:Young Adult
D006514:Hepatitis B Surface Antigens