[Effect of x-ray contrast agents on the thromboresistant properties of vascular walls].
It is established that the x-ray contrast agents urografin, omnipak, and ultravist produce a dose-dependent decrease in the thromboresistant properties of vascular walls in experimental rats. This effect is determined by the individual properties of substances rater than by their belonging to a certain class of ionic or nonionic compounds. Preliminary administration of n3-polyunsaturated fatty acids from fish oil offers a significant protection against the negative action of x-ray contrast agents and retains the antiaggregant activity of the vessel wall intima.
Klimanova
E V
EV
Makarov
V A
VA
Petrukhina
G N
GN
Bolotova
E N
EN
Shimanovskiĭ
N L
NL
D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology; D005260:Female; D005395:Fish Oils; D006801:Humans; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017539:Tunica Intima / Q000187:drug effects* / Q000502:physiology
D003287:Contrast Media; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D003974:Diatrizoate Meglumine; D007472:Iohexol; C038192:iopromide