n-3 phosphatidylserine attenuated scopolamine-induced amnesia in middle-aged rats.
Phosphatidylserine (PS) extracted from bovine brain differs from transphosphatidylated soybean lecithin PS (SB-PS) in its n-3 long-chain polyunsaturated fatty acid (LC-PUFA) content. Both, however, were suggested to affect cognitive performance. We compared the effect of chronic administration of a novel n-3 LC-PUFA PS conjugates (n-3 PS) versus SB-PS, fish oil (FO), SB-PS+FO, or control oil in middle-aged rats, on brain fatty acids composition and performance in behavioral tasks. Our hypothesis was that the n-3 LC-PUFA vehicles will affect these outcomes better than the other diets. Brain phospholipid docosahexaenoic acid levels increased significantly (p=0.0434) with n-3 PS only. None of the treatments affected the animals' task performance in compare with the control, although reversal from the non-match-to-sample to match-to-sample rule in the T-maze differed (p=0.0434) between the experimental diets. Conversely, the acquisition of the Morris water maze task was impaired by scopolamine (SCO) in all but the n-3 PS group (p=0.0019). In the probe, when pretreated with SCO, the SB-PS+FO group and to a lesser degree the n-3 PS group, spent longer latency times (p=0.0390) in the non-peripheral zones of the water maze compared to the control; this may be interpreted as anxiolytic-like behavior. These results suggest that the n-3 LC-PUFA carrier may play a role in these fatty acids bioavailability and their impact on specific cognitive processes.
Vaisman
Nachum
N
Clinical Nutrition Unit, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel. vaisman@tasmc.health.gov.il
Pelled
Dori
D
D000367:Age Factors; D000647:Amnesia / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D002417:Cattle; D015525:Fatty Acids, Omega-3 / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D010718:Phosphatidylserines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D037121:Plant Lectins / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000633:toxicity*; D030262:Soybean Proteins / Q000494:pharmacology / Q000627:therapeutic use; D010835:Phytohemagglutinins
D015525:Fatty Acids, Omega-3; D010718:Phosphatidylserines; D037121:Plant Lectins; D012601:Scopolamine; D030262:Soybean Proteins; C028824:soybean lectin; D010835:Phytohemagglutinins