Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants.
OBJECTIVE
We previously demonstrated that exposure to polyvinyl chloride plastic medical devices containing di(2-ethylhexyl) phthalate (DEHP) was associated with higher urinary concentrations of several DEHP metabolites in 54 premature infants in two neonatal intensive care units than in the general population. For 42 of these infants, we evaluated urinary concentrations of several phenols, including bisphenol A (BPA), in association with the use of the same medical devices.


METHODS
We measured the urinary concentrations of free and total (free plus conjugated) species of BPA, triclosan, benzophenone-3, methyl paraben, and propyl paraben.


RESULTS
The percentage of BPA present as its conjugated species was > 90% in more than three-quarters of the premature infants. Intensity of use of products containing DEHP was strongly associated with BPA total concentrations but not with any other phenol. Adjusting for institution and sex, BPA total concentrations among infants in the group of high use of DEHP-containing products were 8.75 times as high as among infants in the low use group (p < 0.0001). Similarly, after adjusting for sex and DEHP-containing product use category, BPA total concentrations among infants in Institution A were 16.6 times as high as those among infants in Institution B (p < 0.0001).


CONCLUSIONS
BPA geometric mean urinary concentration (30.3 microg/L) among premature infants undergoing intensive therapeutic medical interventions was one order of magnitude higher than that among the general population. Conjugated species were the primary urinary metabolites of BPA, suggesting that premature infants have some capacity to metabolize BPA. The differences in exposure to BPA by intensity of use of DEHP-containing medical products highlight the need for further studies to determine the specific source(s) of exposure to BPA.
Calafat
Antonia M
AM
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. acalafat@cdc.gov
Weuve
Jennifer
J
Ye
Xiaoyun
X
Jia
Lily T
LT
Hu
Howard
H
Ringer
Steven
S
Huttner
Ken
K
Hauser
Russ
R
D001559:Benzhydryl Compounds; D001577:Benzophenones / Q000652:urine; D004051:Diethylhexyl Phthalate; D004781:Environmental Exposure / Q000706:statistics & numerical data; D016021:Epidemiologic Studies; D004864:Equipment and Supplies; D004968:Estrogens, Non-Steroidal / Q000652:urine*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000652:urine*; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D008297:Male; D010226:Parabens / Q000378:metabolism; D010636:Phenols / Q000652:urine*; D010968:Plasticizers; D012307:Risk Factors; D014260:Triclosan / Q000652:urine; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D001577:Benzophenones; D004051:Diethylhexyl Phthalate; D004968:Estrogens, Non-Steroidal; D010226:Parabens; D010636:Phenols; D010968:Plasticizers; D014260:Triclosan; C005290:oxybenzone; C006780:bisphenol A; D000098826:Bisphenol A Compounds