Identification of relaxin-responsive cells in the human choriodecidua at term.
The decidua of the human maternal-fetal interface is a local source of intrauterine relaxin, and the choriodecidua expresses its receptor (LGR7). Since these tissues consist of a variety of cells, we sought to identify the primary cell(s) responsible for LGR7 expression and relaxin responsiveness.
Horton
Jaime S
JS
Department of Cell and Molecular Biology, University of Hawaii, Honolulu, Hawaii, USA. jshorton@hawaii.edu
Yamamoto
Sandra Y
SY
Bryant-Greenwood
Gillian D
GD
D002460:Cell Line; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D003656:Decidua / Q000166:cytology* / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011256:Pregnancy Outcome; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D018000:Receptors, Peptide / Q000235:genetics; D012065:Relaxin / Q000494:pharmacology*; D017154:Stromal Cells / Q000187:drug effects* / Q000378:metabolism*
C417543:RXFP1 protein, human; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide; D012065:Relaxin; D000242:Cyclic AMP; D020782:Matrix Metalloproteinases