[Predictive value of interleukin 6 from the umbilical cord blood in early neonatal infection].
We have analyzed diagnostic value of interleukin 6 (IL-6) from the umbilical cord blood in recognition of early neonatal infection (ENI) of newborns whose mothers have obstetrical risks. The study included 120 newborns with birth weight <2500 gr., gestational age from 37 to 42 weeks, which mothers had some of the obstetrical risks. We established three groups: group A (newborns with microbiological proof of ENI), group B (clinical signs and hematological parameters of ENI) and group C (newborns without ENI). Median of IL-6 value in group A was 48.5 pg/ml with sensitivity, specificity and diagnostic value in recognition of ENI 78%, 81% and 80%. In group B median of IL-6 was 49 pg/ml with sensitivity, specificity and diagnostic value 65%, 80% and 77%. In group C median of IL-6 was 9.7 pg/ml. We noticed significant connection between value of IL-6 and mother's urinary tract infection; group A (p=0.023), group B (p = 0.007). Also there was a remarkable relationship between mother's colpitis and level of IL-6 in newborn with ENI in group A (p=0.011) and group B (p = 0.012). High levels of IL-6 in umbilical cord blood can help us in recognition of newborns that are endangered by infection and they are clearly connected with some of mother's obstetrical risks.
Cosićkić
Almira
A
Klinika za djecije bolesti, Univerzitetski klinicki centar Tuzla, BiH. almira_cosickic@yahoo.com
Skokić
Fahrija
F
D015415:Biomarkers / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000175:diagnosis*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012307:Risk Factors; D012680:Sensitivity and Specificity
D015415:Biomarkers; D015850:Interleukin-6