The role of CD4 T cell help for CD8 CTL activation.
CD4 T cells play an important role in the initiation and persistence of CD8 T cells responses. In this review, we report on and evaluate the mechanisms by which CD4 T cells contribute to activation of CD8 T cells and the signal pathways of the down-streaming events after CD4 T cell help.
Medical Oncology, First People's Hospital, Shanghai Jiaotong University, 650 Xinsongjiang Road, Shanghai 201620, China. wozhangsheng@hotmail.com
Sheng
S
Zhang
Hongjun
H
Zhang
Jiandong
J
Zhao
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D045142:Cross-Priming; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*