Synthesis and applications of silicon-containing alpha-amino acids.
Amino acids serve not only as monomers for proteins and enzymes but also as important players in signal transduction pathways. They belong to the abundant feedstock of the pharmaceutical, food science and agrochemical industries, and some are used as catalysts or ligand components. In recent years, non-proteogenic amino acids have taken on important roles. This tutorial review summarises the progress in the development of strategies to construct silicon-containing alpha-amino acid frameworks and the studies concerned with their structure and activity. It shall be of interest for the synthesis and biosciences communities.
Institut für Organische Chemie der RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany.
Matthew
M
Mortensen
Ralph
R
Husmann
Elisabetta
E
Veri
Carsten
C
Bolm
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D012825:Silicon / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D012825:Silicon