CCL8/MCP-2 association analysis in patients with Alzheimer's disease and frontotemporal lobar degeneration.
CCL2/Monocyte Chemoattractant Protein (MCP)-1 and other chemokines sharing a similar sequence, including CCL8/MCP-2, are involved in neurodegeneration. A few Single Nucleotide Polymorphisms (SNPs) have been reported in CCL8/MCP-2, all of which are located in the same linkage block. One of them (rs1163763) leads to an aminoacidic substitution, implying a potential impact on the function of the protein. rs1133763 was tested for association in 219 patients with Alzheimer's disease (AD) and 209 with Frontotemporal Lobar Degeneration (FTLD) as compared with 231 age-matched controls. The distribution of CCL8/MCP-2 rs1133763 was not significantly different among patients with AD or FTLD and controls, even stratifying according to gender. CCL8/MCP rs1133763 SNP, or other variants in linkage disequilibrium with this variant, likely do not influence the susceptibility to AD or FTLD in Caucasians.
Villa
Chiara
C
Venturelli
Eliana
E
Fenoglio
Chiara
C
Clerici
Francesca
F
Marcone
Alessandra
A
Benussi
Luisa
L
Ghidoni
Roberta
R
Gallone
Salvatore
S
Cortini
Francesca
F
Scalabrini
Diego
D
Serpente
Maria
M
Binetti
Giuliano
G
Cappa
Stefano
S
Mariani
Claudio
C
Rainero
Innocenzo
I
Bresolin
Nereo
N
Scarpini
Elio
E
Galimberti
Daniela
D
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D019943:Amino Acid Substitution / Q000235:genetics; D054412:Chemokine CCL8 / Q000235:genetics*; D004252:DNA Mutational Analysis; D003704:Dementia / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D044465:White People / Q000235:genetics
C515453:CCL8 protein, human; D054412:Chemokine CCL8; D005819:Genetic Markers