The complex relationship between magnesium and serum parathyroid hormone: a study in patients with chronic intestinal failure.
In this study we compared the content of muscle free [Mg2+] assessed by 31P MRS to that of serum total Mg assessed by routine colorimetric assays in 15 patients affected by Chronic Intestinal Failure (CIF) on long-term Home Parenteral Nutrition (HPN) or who had undergone isolated intestinal transplantation. We also investigated in the same cohort of patients the relationship of muscle free [Mg2+] and serum total Mg with parathyroid hormone (PTH) serum content. All patients showed a normal cytosolic free [Mg2+] in the calf muscle despite about half of them having a content of total serum [Mg] below or at the lower edge of the boundary limits. Muscle free Mg2+ and serum total Mg displayed an opposite correlation versus serum PTH, showing that the intracellular free form possesses a different functional metabolic meaning in the regulation of PTH secretion.
Dipartimento di Medicina Interna dell'Invecchiamento e delle Malattie Nefrologiche, Università di Bologna, Bologna, Italy.
Loris
L
Pironi
Emil
E
Malucelli
Mariacristina
M
Guidetti
Elisabetta
E
Lanzoni
Giovanna
G
Farruggia
Antonio Daniele
AD
Pinna
Bruno
B
Barbiroli
Stefano
S
Iotti
D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000378:metabolism*; D007422:Intestines / Q000637:transplantation; D008274:Magnesium / Q000097:blood* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood*; D016331:Parenteral Nutrition, Home / Q000009:adverse effects
D010281:Parathyroid Hormone; D008274:Magnesium