Asymmetric Syntheses of L,L- and L,D-di-myo-inositol-1,1'-phosphate and their behavior as stabilizers of enzyme activity at extreme temperatures.
The big "DIP"per: The preparation of both l,l-DIP and l,d-DIP (see structures) involves a complex case of double asymmetric induction in the key step of the synthesis. The differential ability of each isomer to contribute to thermoprotection in the context of a key enzyme has been assessed and both isomers of DIP are shown to possess biological activity.
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-4900, USA.
Christina M
CM
Longo
Yang
Y
Wei
Mary F
MF
Roberts
Scott J
SJ
Miller
D019611:Archaeoglobus fulgidus / Q000201:enzymology; D002384:Catalysis; D004795:Enzyme Stability; D006358:Hot Temperature; D007295:Inositol Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D020124:Thermotoga maritima / Q000201:enzymology
D007295:Inositol Phosphates; C075843:di-myo-inositol-1,1'-phosphate