How to map billions of short reads onto genomes.
Mapping the vast quantities of short sequence fragments produced by next-generation sequencing platforms is a challenge. What programs are available and how do they work?
Trapnell
Cole
C
Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA. cole@cs.umd.edu
Salzberg
Steven L
SL
D000465:Algorithms; D001483:Base Sequence; D016678:Genome; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA; D012984:Software