A mild, efficient method for the oxidation of alpha-diazo-beta-hydroxyesters to alpha-diazo-beta-ketoesters.
A wide variety of alpha-diazo-beta-ketoesters can be prepared in good overall yields via a two-step sequence involving addition of ethyl lithiodiazoacetate to aliphatic, aromatic and conjugated aldehydes followed by mild oxidation with the Dess-Martin periodinane.
Li
Puhui
P
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylania 16802 USA.
Majireck
Max M
MM
Korboukh
Ilia
I
Weinreb
Steven M
SM