Glucose responsive hydrogel networks based on protein recognition.
Stimuli-responsive materials capable of manifesting physical changes in response to environmental signals are valuable tools for use in a variety of biomedical applications. Herein we describe one such smart glucose-responsive hydrogel material prepared by immobilizing the glucose/galactose binding protein within an acrylamide hydrogel network. This hydrogel demonstrates a quantitative "accordion"-like dynamic response in the presence of glucose. We further show the feasibility of employing this responsive smart material as a gating agent for controlled drug delivery, thus, demonstrating that these hydrogels may eventually lead to the development of implantable drug delivery systems for diabetes management applications.
Ehrick
Jason D
JD
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
Luckett
Matthew R
MR
Khatwani
Santoshkumar
S
Wei
Yinan
Y
Deo
Sapna K
SK
Bachas
Leonidas G
LG
Daunert
Sylvia
S
D015374:Biosensing Techniques / Q000379:methods*; D016503:Drug Delivery Systems; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics; D005947:Glucose / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics; D008958:Models, Molecular; D009004:Monosaccharide Transport Proteins / Q000737:chemistry / Q000235:genetics; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*
D029968:Escherichia coli Proteins; D020100:Hydrogels; D008562:Membrane Glycoproteins; D009004:Monosaccharide Transport Proteins; D011506:Proteins; D005947:Glucose