Enhanced anti-inflammatory effects of celecoxib from a transdermally applied nanoemulsion.
The aim of the present study was to evaluate the enhanced anti-inflammatory effects of celecoxib (CXB) from a transdermally applied nanoemulsion. The anti-inflammatory effects of an optimized nanoemulsion formulation were compared with those of conventional CXB gel and nanoemulsion gel on carrageenan-induced paw edema in rats. These tests were compared using the Dunnett test of one-way analysis of variance (ANOVA). The % inhibition value after 24 h application was significant for optimized formulation C2 (85.4%) compared with CXB gel and nanoemulsion gel (p < 0.05). These results suggest that nanoemulsions can be successfully used to enhance the anti-inflammatory effects of CXB.
Department of Pharmaceutics, Faculty of Pharmacy, Alarab Medical University, Benghazi, Libya. faiyazs@fastmail.fm
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F
Shakeel
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S
Baboota
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A
Ahuja
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J
Ali
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S
Shafiq
D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000494:pharmacology*; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology*; D004655:Emulsions; D005079:Excipients; D008297:Male; D053758:Nanoparticles; D011720:Pyrazoles / Q000008:administration & dosage* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption; D013449:Sulfonamides / Q000008:administration & dosage* / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D004655:Emulsions; D005079:Excipients; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib