Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart.
In this study, we review the development and application of multi-physics and multi-scale coupling in the construction of whole-heart physiological models. Through an examination of recent computational modelling developments, we analyse the significance of coupling mechanisms for the increased understanding of cardiac function in the areas of excitation-contraction, coronary blood flow and ventricular fluid mechanical coupling. Within these physiological domains, we demonstrate and discuss the importance of model parametrization, imaging-based model anatomy and computational implementation.
Lee
Jack
J
Oxford University Computing Laboratory, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, UK.
Niederer
Steven
S
Nordsletten
David
D
Le Grice
Ian
I
Smaill
Bruce
B
Smail
Bruce
B
Kay
David
D
Smith
Nicolas
N
D003331:Coronary Vessels / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans