Combining clinical assessment scores and in vivo MR spectroscopy neurometabolites in very low birth weight adolescents.
OBJECTIVE
Very low birth weight (VLBW) survivors are at increased risk of neurological impairments that may persist into adolescence and adulthood. The aims of this study were to identify the most important clinical assessments that characterize differences between VLBW and control adolescents, and to look at the relationship between clinical assessments and the metabolites in in vivo MR spectra.


METHODS
At 14-15 years of age, 54 VLBW survivors and 64 term controls were examined clinically. Several neuropsychological and motor assessments were performed. The magnetic resonance (MR) brain spectra were acquired from volumes localized in the left frontal lobe and contained mainly white matter.


RESULTS
Probabilistic neural networks and support vector machines demonstrated that clinical assessments rendered a possibility of the classification of VLBW versus control adolescents. The most important clinical assessments in this classification were visual-motor integration, motor coordination, stroop test, full scale IQ, and grooved pegboard. Through the use of outer product analysis-partial least squares discriminant analysis on a subset of adolescents (n=36), the clinical assessments found to most strongly correlate with the spectral data were the global assessment scale, Wisconsin card sorting test, full scale IQ, grooved pegboard test, and motor coordination test. Clinical assessments that relate to spectral data may be especially dependent on an intact microstructure in frontal white matter.
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), 7489 Trondheim, Norway. tone.f.bathen@ntnu.no
Tone F
TF
Bathen
Gro C
GC
Christensen Løhaugen
Ann-Mari
AM
Brubakk
Ingrid S
IS
Gribbestad
David E
DE
Axelson
Jon
J
Skranes
D000293:Adolescent; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D010808:Physical Examination