New method to prepare very stable and biocompatible fluorescent silica nanoparticles.
A new synthetic method has been developed to prepare fluorescent silica nanoparticles without employing isothiocyanated dye molecules and (3-aminopropyl)triethoxysilane (APS) for the thiourea linkage formation; the resulting fluorescent silica nanoparticles show excellent photochemical, thermal and pH stabilities and a good biocompatibility with over 85% viability from various cell types.
Department of Chemistry, Seoul National University, Seoul, Korea.
Shin-Woo
SW
Ha
Corinne E
CE
Camalier
George R
GR
Beck
Jin-Kyu
JK
Lee
D016475:3T3 Cells; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005453:Fluorescence; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D010777:Photochemistry; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry* / Q000633:toxicity*; D013696:Temperature
D012821:Silanes; C040733:tetraethoxysilane; D012822:Silicon Dioxide