IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes.
Recent genome-wide association (GWA) studies of type 2 diabetes (T2D) have implicated IGF2 mRNA-binding protein 2 (IMP2/IGF2BP2) as one of the several factors in the etiology of late onset diabetes. IMP2 belongs to a family of oncofetal mRNA-binding proteins implicated in RNA localization, stability, and translation that are essential for normal embryonic growth and development. This review provides a background to the IMP protein family with an emphasis on human IMP2, followed by a closer look at the GWA studies to evaluate the significance, if any, of the proposed correlation between IMP2 and T2D.
Christiansen
Jan
J
Department of Biology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Kolte
Astrid M
AM
Hansen
Thomas v O
Tv
Nielsen
Finn C
FC
D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010802:Phylogeny; D016601:RNA-Binding Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*
C498779:IGF2BP2 protein, human; D016601:RNA-Binding Proteins