Comparative study of retinal nerve fiber layer thickness in normal eyes, ocular hypertensives, preperimetric glaucoma and glaucomatous subjects.
We assessed and compared the retinal nerve fiber layer (RNFL) thickness in normal eyes, ocular hypertensives, preperimetric glaucoma and glaucomatous subjects by means of optical coherence tomography in 449 eye. RNFL in glaucoma patients was significantly thinner than in normal subjects in every location evaluated. Use of optical coherence tomography detects glaucomatous RNFL losses in preperimetric glaucoma and can improve our ability to detect structural damage in clinical practice.
Polo
Vicente
V
Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain. vicpolo@telefonica.net
Larrosa
Jose M
JM
Ferreras
Antonio
A
de la Casa
Jose M Martinez
JM
Pablo
Luis E
LE
Honrubia
Francisco M
FM
D019540:Area Under Curve; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012016:Reference Values; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D014065:Tonometry, Ocular; D014794:Visual Fields