beta-TCP/MCPM-based premixed calcium phosphate cements.
Novel premixed calcium phosphate cements (CPCs) were prepared by combining cement liquids comprised of glycerol or polyethylene glycol with CPC powders that consisted of beta-tricalcium phosphate (beta-TCP) and monocalcium phosphate monohydrate (MCPM). Changing the powder to liquid mass ratio enabled the setting time to be regulated, and improved the compressive strength of the CPCs. Although some ratios of the new premixed CPCs had long setting times, these ranged from 12.4 to 27.8 min which is much shorter than the hour or more reported previously for a premixed CPC. The premixed CPCs had tolerable washout resistance before final setting, and the cements had strengths matching that of cancellous bone (5-10 MPa); their maximum compressive strength was up to 12 MPa. The inflammatory response around the premixed CPCs implanted in the subcutaneous tissue in rabbits was more prominent than that of apatite cement. These differences might be due to the much faster resorption rate of the premixed CPCs.
Han
Bing
B
School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.
Ma
Peng-Wei
PW
Zhang
Li-Li
LL
Yin
Yu-Ji
YJ
Yao
Kang-De
KD
Zhang
Fu-Jiang
FJ
Zhang
Yong-Dong
YD
Li
Xiu-Lan
XL
Nie
Wei
W
D000268:Adhesiveness; D000818:Animals; D001843:Bone Cements / Q000138:chemical synthesis* / Q000633:toxicity; D002130:Calcium Phosphates / Q000737:chemistry* / Q000633:toxicity; D003460:Crystallization / Q000379:methods; D006244:Hardness; D008422:Materials Testing; D011817:Rabbits
D001843:Bone Cements; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous