Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.
We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.
Kasper
Amanda C
AC
Department of Chemistry, Duke University, Durham, NC 27708, USA.
Moon
Eui Jung
EJ
Hu
Xiangqian
X
Park
Yongho
Y
Wooten
Ceshea M
CM
Kim
Hyoungsu
H
Yang
Weitao
W
Dewhirst
Mark W
MW
Hong
Jiyong
J
D000818:Animals; D002460:Cell Line; D005663:Furans / Q000737:chemistry*; D051793:Hypoxia-Inducible Factor 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017705:Lignans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D005663:Furans; D051793:Hypoxia-Inducible Factor 1; D017705:Lignans; D042461:Vascular Endothelial Growth Factor A; C018674:tetrahydrofuran; C054895:manassantin A