[Recent clinical and medical economic studies].
The immunonutrients composing the immunonutrition solutions such as Impact have been demonstrated to reinforce the immune defenses and limit postoperative complications. This reduction in infectious morbidity may be related to the ability of immunonutrients to prevent the postoperative imbalance of the T-CD4 lymphocyte subpopulations (Th1/Th2 ratio) and to modulate the inflammatory response. Immunonutrition also acts with the healing process, in particular with arginine, which promotes collagen synthesis. The beneficial effects of immunonutrition are important in all digestive cancer surgery, including esophageal surgery. It is administered preoperatively to all patients for at least 5 days and is recommended postoperatively for undernourished patients for at least 7 days. Finally, the reduction in postoperative morbidity decreases hospital costs, which easily compensates the additional cost of the pharmaconutrients, another argument in favor of prescribing them systematically in patients operated on for digestive cancer.
Pôle d'Anesthésie Reanimation, Hôpital Claude Huriez, Lille. g-lebuffe@chru-lille.fr
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D004066:Digestive System Diseases / Q000601:surgery*; D016629:Esophagectomy; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D044342:Malnutrition / Q000188:drug therapy* / Q000276:immunology; D011183:Postoperative Complications / Q000191:economics / Q000276:immunology / Q000517:prevention & control*
D007155:Immunologic Factors