Molecular mechanisms of projection neuron production and maturation in the developing cerebral cortex.
The cerebral cortex is a brain structure unique to mammals and highly adapted to process complex information. Through multiple developmental steps, the cerebral cortex is assembled as a huge diversity of neurons comprising a complex laminar structure, and with both local and long-distance connectivity within the nervous system. Key processes must take place during its construction, including: (i) regulation of the correct number of neurons produced by progenitor cells, (ii) temporal and spatial generation of neuronal diversity, and (iii) control of neuron migration and laminar positioning as well as terminal differentiation within the mature cortex. Here, we seek to highlight recent cellular and molecular findings underlying these sequential steps of neurogenesis, cell fate specification and migration during cortical development, with particular emphasis on cortical projection neurons.
Mérot
Yohann
Y
DECA Group, DEPSN UPR2197 CNRS, Avenue de la terrasse 91198 Gif sur Yvette, France. merot@inaf.cnrs-gif.fr
Rétaux
Sylvie
S
Heng
Julian Ik-Tsen
JI
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D002540:Cerebral Cortex / Q000196:embryology*; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors