Survival of metastatic colorectal cancer patients treated with chemotherapy in Alberta (1995-2004).
OBJECTIVE
Clinical trials have suggested that advances in chemotherapy significantly improve the survival of patients with metastatic colorectal cancer. Comparable evidence from clinical practice is scarce. This study aims to investigate the survival of patients with metastatic colorectal cancer treated with chemotherapy in Alberta, Canada.


METHODS
Trends of relative survival of patients diagnosed in 1994-2003 were assessed using Alberta Cancer Registry (ACR) data. The median overall survival (OS) of patients diagnosed in 2004 was determined by linking Cancer Registry data with Electronic Medical Records (EMR). Cox regression models were fitted to calculate the hazard ratio for patients treated with chemotherapy.


RESULTS
The 2-year relative survival for patients with metastatic colorectal cancer who received chemotherapy increased significantly from 29% to 41% over the 10 years (1994-2003, p < 0.015). A 69% reduction in the risk of mortality was observed in the 168 patients who received chemotherapy compared to the 87 patients who did not, after adjusting for age, gender, and number of metastases. The median OS of patients who received chemotherapy was 17.5 months. This is comparable to the 18-20 months seen in recently published clinical trials, considering the patients in this study were from the real clinical practice, nearly half of them were older than 70, and many of them might have important co-morbidities.


CONCLUSIONS
The survival of patients diagnosed with metastatic colorectal cancer in Alberta has improved in recent years; this is most likely attributable in large part to the use of chemotherapy.
Chen
Yiqun
Y
Cancer Information and Registries Division, Cancer Institute New South Wales, Level 1 Biomedical Building, Australia Technology Park, Eveleigh, NSW, 2015, Australia. yiqun.chen@cancerinstitute.org.au
Qiu
Zhenguo
Z
Kamruzzaman
Anmmd
A
Snodgrass
Tom
T
Scarfe
Andrew
A
Bryant
Heather E
HE
D000230:Adenocarcinoma / Q000188:drug therapy / Q000401:mortality* / Q000556:secondary*; D000368:Aged; D000416:Alberta / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary; D008297:Male; D010166:Palliative Care / Q000706:statistics & numerical data; D012042:Registries; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome