A novel role for receptor like protein tyrosine phosphatase zeta in modulation of sensorimotor responses to noxious stimuli: evidences from knockout mice studies.
Receptor like protein tyrosine phosphatase zeta (RPTPz) (also known as RPTPbeta or PTPxi) is a tyrosine phosphatase widely expressed in the nervous system, thought to play a role in cell-cell communication. However, knocking out RPTPz does not induce major neural abnormalities in mice. In order to better assess the potential role of RPTPz in various neural functions, we performed a comprehensive behavioural characterization of CNS/PNS functions in knockout mice (RPTPz -/-) confirming previously observed impaired working memory functions and further demonstrating an altered motor coordination. Moreover, RPTPz -/- mice displayed reduced responses to moderate thermal and tactile stimuli, both in baseline and under inflammatory conditions. These findings assign novel functional role of RPTPz in motor coordination and nociception.
Lafont
David
D
Istituto di Ricerche Biomediche A. Marxer, Merck Serono Ivrea Research Centre, 10010 Colleretto Giacosa (TO), Italy. david.lafont@merckserono.net
Adage
Tiziana
T
Gréco
Béatrice
B
Zaratin
Paola
P
D000818:Animals; D001823:Body Composition / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004327:Drinking Behavior / Q000502:physiology; D019054:Evoked Potentials, Motor; D005247:Feeding Behavior / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D010146:Pain / Q000139:chemically induced / Q000378:metabolism*; D010812:Physical Stimulation; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5 / Q000235:genetics / Q000378:metabolism*; D013216:Reflex, Startle / Q000502:physiology*; D012640:Seizures / Q000139:chemically induced; D012684:Sensory Thresholds / Q000502:physiology
C516896:Ptprz1 protein, mouse; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5