Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss.
Marrow stromal cells (MSC) are thought to be stem cells with osteogenic potential and therefore responsible for the repair and maintenance of the skeleton. Age related bone loss is one of the most prevalent diseases in the elder population. It is controversial whether MSC undergo a process of aging in vivo, leading to decreased ability to form and maintain bone homeostasis with age. In this review we summarize evidence of MSC involvement in age related bone loss and suggest new emerging targets for intervention.
University of Sheffield Medical School, Sheffield S10 2RX, UK. i.bellantuono@shef.ac.uk
Ilaria
I
Bellantuono
Abdullah
A
Aldahmash
Moustapha
M
Kassem
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D001854:Bone Marrow Cells / Q000378:metabolism* / Q000473:pathology; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D016922:Cellular Senescence; D006706:Homeostasis; D006801:Humans; D010024:Osteoporosis / Q000378:metabolism* / Q000473:pathology; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology