Stimuli-responsive controlled drug release from magnetic-sensitive silica nanospheres.
A novel method for control burst releasing of drug via a high frequency magnetic field (HFMF) from magnetic-sensitive silica nanospheres was developed. The nanospheres were synthesized by a combination of emulsion and sol-gel process with the particles controlled at about 80 nm in diameter. Under repeated exposures to the high frequency magnetic stimulus, the drug release behaviors showed reproducible slow-to-burst profiles while consecutively applying the magnetic stimulus at 10-min switching time and the release profile restored immediately when the stimulus was removed. By taking this non-contact control-burst method, the magnetic silica nanospheres can be designed to treat the cancer therapy and urgent physiological needs.
Hu
Shang-Hsiu
SH
Department of Materials Sciences and Engineering, National Chiao Tung University, Hsinchu, Taiwan, 300, China.
Liu
Ting-Yu
TY
Huang
Hsin-Yang
HY
Liu
Dean-Mo
DM
Chen
San-Yuan
SY
D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D054118:Nanospheres; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012822:Silicon Dioxide
D004364:Pharmaceutical Preparations; D012822:Silicon Dioxide