Semen parameters and hormonal profile in obese fertile and infertile males.
OBJECTIVE
To study the changes in semen parameters, gonadotropic and sex hormones, and serum leptin in obese fertile and infertile oligozoospermic men.


METHODS
Prospective.


METHODS
University hospital.


METHODS
Forty-two obese fertile and 80 obese infertile oligozoospermic men (body mass index [BMI] >30).


METHODS
The BMI calculation, semen analysis, and serum FSH, LH, T, E(2), PRL, and leptin estimation.


METHODS
Semen and hormonal profiles.


RESULTS
Obese oligozoospermic patients had significant increase in mean BMI, serum FSH, LH, E(2), PRL, and leptin compared with obese fertile controls. The BMI had significant positive correlation with abnormal sperm morphology, LH, serum leptin and significant negative correlation with sperm concentration, sperm motility, serum T. Serum leptin demonstrated significant positive correlation with patients' age, abnormal sperm morphology, serum FSH, LH, PRL and significant negative correlation with sperm concentration, sperm motility, and serum T.


CONCLUSIONS
Serum leptin mediates a link between obesity and male infertility.
Hofny
Eman R M
ER
Department of Dermatology, Venereology & Andrology, Faculty of Medicine, Assiut University, Assuit, Egypt.
Ali
Mohamed E
ME
Abdel-Hafez
Hisham Z
HZ
Kamal
Emad El-Dien
Eel-D
Mohamed
Essam Eldien
EE
Abd El-Azeem
Hanan G
HG
Mostafa
Taymour
T
D000328:Adult; D015992:Body Mass Index; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications; D009845:Oligospermia / Q000097:blood* / Q000150:complications / Q000473:pathology*; D011388:Prolactin / Q000097:blood; D011446:Prospective Studies; D013081:Sperm Motility; D013094:Spermatozoa / Q000473:pathology*; D013739:Testosterone / Q000097:blood
D006728:Hormones; D020738:Leptin; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone