Long-term effects of surgical correction of adrenal hyperplasia and adenoma causing primary aldosteronism.
OBJECTIVE
The purpose of this is to study long-time results of surgery for primary aldosteronism.


METHODS
Thirty patients operated on for primary aldosteronism were followed for an average of 7 years. All but five required potassium substitution. Systolic as well as diastolic hypertension (mean 157/93 mmHg) was present necessitating one to five antihypertensive drugs daily (mean 2.33). Preoperative indications for surgery included presumed adenoma (aldosterone-producing adenoma (APA)) or in one case unilateral dominance of hyperplasia.


RESULTS
Histopathology was classified into adenoma (n = 9), dominant nodule (n = 16), and general hyperplasia without dominating nodules (n = 5), demonstrating a higher frequency of hyperplasia than anticipated. Long-term results revealed well-controlled blood pressure (BP; mean 134/80 mmHg). Antihypertensive medication was reduced (average of 1.78 per day), but only 36% of the patients were taken off these drugs completely. S-Aldosterone was normalized. All but one (a recurrence) were normokalemic without potassium substitution at follow-up. The APA group needed less medication (median 0.5 vs. 1.5 and 2 per day) and more patients in this group were totally medication free (50%). Two recurrences occurred in the group with general hyperplasia without dominating nodules.


CONCLUSIONS
Nodular hyperplasia is more common than anticipated. Hypersecretion of aldosterone may be released from a large nodule identified as an adenoma, as well as from a generally hyperplastic gland that has not been identified as such. Nevertheless, surgery for lateralized disease results in good long-term control of BP with less antihypertensive medication. However, patients with dominant nodule or general hyperplasia without dominating nodules need more postoperative treatment than patients with APA. The majority of patients do not achieve normotension without medications, but they do become normokalemic.
Department of Surgical Sciences, Uppsala University Hospital, 751 85, Uppsala, Sweden. joakim.hennings@surgsci.uu.se
J
J
Hennings
S
S
Andreasson
J
J
Botling
A
A
Hägg
A
A
Sundin
P
P
Hellman
D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D000311:Adrenal Glands / Q000473:pathology*; D000315:Adrenalectomy; D000450:Aldosterone / Q000097:blood; D000704:Analysis of Variance; D015984:Causality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D006965:Hyperplasia / Q000150:complications / Q000601:surgery; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007008:Hypokalemia / Q000188:drug therapy / Q000209:etiology; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome
D000450:Aldosterone; D012083:Renin