Triggered release of an active peptide conjugate from a DNA device by an orally administrable small molecule.
A real tonic: In a conceptually new approach to controlled release, the natural daily insulin profile in response to three meals is mimicked (see graph) with release of an insulin conjugate from a matrix, triggered by quinine, a component of tonic water.
Department of Medicine, Division of Experimental Therapeutics, The NSF Center for Molecular Cybernetics, Columbia University, 630 W. 168th St., Box 84, New York, NY 10032, USA. st2171@columbia.edu
Steven K
SK
Taylor
Renjun
R
Pei
Byoung C
BC
Moon
Srikanth
S
Damera
Aihua
A
Shen
Milan N
MN
Stojanovic
D000284:Administration, Oral; D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000737:chemistry; D007328:Insulin / Q000008:administration & dosage* / Q000737:chemistry; D008969:Molecular Sequence Data; D011803:Quinine / Q000737:chemistry*; D020349:Surface Plasmon Resonance
D004337:Drug Carriers; D007004:Hypoglycemic Agents; D007328:Insulin; D004247:DNA; D011803:Quinine