Maternal enrichment affects prenatal hippocampal proliferation and open-field behaviors in female offspring mice.
The maternal environment is thought to be important for fetal brain development. However, the effects of maternal environment are not fully understood. Here, we investigated whether enrichment of the maternal environment can influence prenatal brain development and postnatal behaviors in mice. An enriched environment is a housing condition with several objects such as a running wheel, tube and ladder, which are thought to increase sensory, cognitive and motor stimulation in rodents compared with standard housing conditions. First, we measured the number of BrdU-positive cells in the hippocampal dentate gyrus of fetuses from pregnant dams housed in an enriched environment. Our results revealed that maternal enrichment influences cell proliferation in the hippocampus of female, but not male, fetuses. Second, we used the open-field test to investigate postnatal behaviors in the offspring of dams housed in the enriched environment during pregnancy. We found that maternal enrichment significantly affects the locomotor activity and time spent in the center of the open-field in female, but not male, offspring. These results indicate that maternal enrichment influences prenatal brain development and postnatal behaviors in female offspring.
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.
Takashi
T
Maruoka
Ikuko
I
Kodomari
Rena
R
Yamauchi
Etsuko
E
Wada
Keiji
K
Wada
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D049109:Cell Proliferation; D004777:Environment; D005260:Female; D005333:Fetus; D006624:Hippocampus / Q000166:cytology* / Q000196:embryology*; D006799:Housing, Animal; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000502:physiology; D011247:Pregnancy