Putting a break on protein translocation: metabolic regulation of mitochondrial protein import.
Sequence-inherent targeting information directs polypeptides synthesized in the cytosol to their respective cellular compartment. Some proteins use ambiguous sorting signals or specific folding properties to be dually distributed between the cytosol and mitochondria. A study published in this issue of Molecular Microbiology shows that in the case of fumarase this distribution is controlled by the metabolic state of yeast cells. The metabolite-dependent distribution of fumarase represents an exciting example of regulated protein import into mitochondria that shows that eukaryotes can adapt the intracellular protein distribution to their physiological conditions.
Cell Biology, University of Kaiserslautern, Kaiserslautern, Germany. hannes.herrmann@biologie.uni-kl.de
Johannes M
JM
Herrmann
D003600:Cytosol / Q000378:metabolism; D005649:Fumarate Hydratase / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D006038:Glyoxylates / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism
D006038:Glyoxylates; D029701:Saccharomyces cerevisiae Proteins; D005649:Fumarate Hydratase; C031150:glyoxylic acid