Preparation and characterization of tea polyphenols and vitamin E loaded nanoscale complex liposome.
The purpose of the present work was to prepare nanoscale complex liposome loaded both aqueous soluble drug tea polyphenols (TP) and insoluble drug vitamin E (VE) by reverse-phase evaporation method. The preparation formulation of TP-VE complex liposome was optimized by the orthogonal experiment. The entrapment efficiency of TP was (50.81 +/- 1.91)% while that of VE was (94.05 +/- 3.45)% for the optimal formulation. The results of penetration experiments of TP-VE liposome demonstrated a slight influence of the concentration of TP and the content of cholesterol on the penetration quantity of TP. These results indicate that the complex liposome offers a new approach to entrap aqueous soluble drug and poorly soluble drug, an inner liposome protection, a relatively high drug encapsulation efficiency and a sustained transdermal penetration.
Ma
Q H
QH
School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210096, P. R. China.
Kuang
Y Z
YZ
Hao
X Z
XZ
Gu
N
N
D005419:Flavonoids / Q000737:chemistry*; D008081:Liposomes; D036103:Nanotechnology; D010636:Phenols / Q000737:chemistry*; D059808:Polyphenols; D013662:Tea / Q000737:chemistry*; D014810:Vitamin E / Q000737:chemistry*
D005419:Flavonoids; D008081:Liposomes; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D014810:Vitamin E