Purine uptake in Plasmodium: transport versus metabolism.
In a recent paper, Quashie et al. have proposed that purine uptake into the intraerythrocytic malaria parasite involves four different plasma membrane transporters - two high affinity and two low affinity. They equate one of the two high-affinity transporters with PfNT1, a transporter reported previously to be a low-affinity system. Here, we offer an alternative interpretation of their data, suggesting that the conclusions drawn by Quashie et al. take insufficient account of metabolism.
Kirk
Kiaran
K
Biochemistry and Molecular Biology, School of Biology, The Australian National University, Canberra ACT 0200, Australia. kiaran.kirk@anu.edu.au
Howitt
Susan M
SM
Bröer
Stefan
S
Saliba
Kevin J
KJ
Downie
Megan J
MJ
D000818:Animals; D001692:Biological Transport; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009865:Oocytes / Q000378:metabolism; D010963:Plasmodium falciparum / Q000378:metabolism* / Q000502:physiology*; D015800:Protozoan Proteins / Q000378:metabolism*; D011687:Purines / Q000378:metabolism*; D014982:Xenopus laevis / Q000469:parasitology
D026901:Membrane Transport Proteins; C407347:NT1 protein, Plasmodium falciparum; D015800:Protozoan Proteins; D011687:Purines; C030985:purine