CEACAM1 distribution and it's effects on angiogenesis and lymphangiogenesis in oral carcinoma.
To investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and its effects on angiogenesis and lymphangiogenesis in oral carcinoma. Immunohistochemistry was used to study the expression of CEACAM1, LYVE1 and CD31, double-labelling immunofluorescence was used to detect the co-expression of CEACAM1 and LYVE1, and double-labelling immunohistochemistry was performed to observe the co-expression of LYVE1 and CD31 in vessels. Membranous CEACAM1 was expressed in well-differentiated squamous cell carcinoma and cytoplastic CEACAM1 in poorly and moderately differentiated carcinoma (P<0.05). More CEACAM1-positive vessels were observed in CEACAM1-positive tumors with cytoplasmic expression than with membranous expression (P<0.001). Co-expression of CEACAM1 and LYVE1, LYVE1 and CD31 in vessels was more common in CEACAM1-positive tumors with cytoplasmic expression than with membranous expression (P<0.001). CEACAM1 has different distribution in oral carcinoma. Membranous CEACAM1 inhibits angiogenesis and lymphangiogenesis, but cytoplasmic CEACAM1 promotes angiogenesis, and even promotes lymphangiogenesis by mediating the transformation of vascular endothelial cells (VECs) into lymphatic endothelial cells (LECs).
Zhou
Cheng-Jun
CJ
Department of Pathology, The School of Stomatology, Shandong University, 44-1#, Wenhua Xi Road, Jinan, Shandong 250012, PR China. chengjunzhou@126.com
Qu
Xun
X
Yang
Yong-Mei
YM
Wang
Fu-Fang
FF
Dong
Zuo-Qing
ZQ
Wang
Cheng-Qin
CQ
Zhang
Xiao-Ying
XY
Liu
Gui-Xiang
GX
Wei
Feng-Cai
FC
Sun
Shan-Zhen
SZ
D015703:Antigens, CD / Q000378:metabolism* / Q000502:physiology*; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism* / Q000502:physiology*; D042783:Endothelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D042583:Lymphangiogenesis / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000098:blood supply / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000209:etiology* / Q000473:pathology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D033921:Vesicular Transport Proteins / Q000378:metabolism
D015703:Antigens, CD; C069847:CD66 antigens; D015815:Cell Adhesion Molecules; C119248:LYVE1 protein, human; D009363:Neoplasm Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D033921:Vesicular Transport Proteins