Hemoglobin variability in nondialysis chronic kidney disease: examining the association with mortality.
OBJECTIVE
Anemia and hemoglobin (Hb) variability are associated with mortality in hemodialysis patients who are on erythropoiesis-stimulating agents (ESA). Our aim was to describe the degree of Hb variability present in nondialysis patients with chronic kidney disease (CKD), including those who were not receiving ESA, and to investigate the association between Hb variability and mortality.


METHODS
Hb variability was determined using 6 mo of "baseline" data between January 1, 2003, and October 31, 2005. A variety of definitions for Hb variability were examined to ensure consistency and robustness.


RESULTS
A total of 6165 patients from 22 centers in seven countries were followed for a mean of 34.0 +/- 15.8 mo; 49% were prescribed an ESA. There was increased Hb variability with ESA use; the residual SD of Hb was 4.9 +/- 4.4 g/L in patients who were not receiving an ESA, compared with 6.8 +/- 4.8 g/L. Hb variability was associated with a small but significantly increased risk for death per g/L residual SD, irrespective of ESA use. Multivariate linear regression model explained only 11% of the total variance of Hb variability.


CONCLUSIONS
Hb variability is increased in patients who have CKD and are receiving ESA and is associated with an increased risk for death (even in those who are not receiving ESAs). This analysis cannot determine whether Hb variability causally affects mortality. Thus, the concept of targeting Hb variability with specific agents needs to be examined within the context of factors that affect both Hb variability and mortality.
Boudville
Neil C
NC
School of Medicine and Pharmacology, University of Western Australia, WA, Australia. neil.boudville@uwa.edu.au
Djurdjev
Ognjenka
O
Macdougall
Iain C
IC
de Francisco
Angel L M
AL
Deray
Gilbert
G
Besarab
Anatole
A
Stevens
Paul E
PE
Walker
Rowan G
RG
Ureña
Pablo
P
Iñigo
Pablo
P
Minutolo
Roberto
R
Haviv
Yosef S
YS
Yeates
Karen
K
Agüera
Marisa L
ML
MacRae
Jennifer M
JM
Levin
Adeera
A
D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000188:drug therapy* / Q000401:mortality*; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000401:mortality*; D016019:Survival Analysis
D006454:Hemoglobins; D004921:Erythropoietin