Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects.
This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.
Department of Neurology, School of Medicine, Keio University, Tokyo, Japan. miyaki-keio@umin.net
Koichi
K
Miyaki
Htay
H
Lwin
Katsunori
K
Masaki
Yixuan
Y
Song
Yoshimitsu
Y
Takahashi
Masaaki
M
Muramatsu
Takeo
T
Nakayama
D000328:Adult; D044466:Asian People; D015415:Biomarkers; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D007854:Lead / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011110:Polymorphism, Genetic; D000623:Porphobilinogen Synthase / Q000235:genetics*
D015415:Biomarkers; D007854:Lead; D000623:Porphobilinogen Synthase