Genotypic prediction of human immunodeficiency virus type 1 CRF02-AG tropism.
We assessed the performance of genotypic algorithms for predicting the tropism of human immunodeficiency virus type 1 coreceptor usage in 52 patients infected with the CRF02-AG subtype. The combined criteria of the 11/25 and net charge rules accurately detected CXCR4-using CRF02-AG viruses, whereas the Geno2pheno tool lacked sensitivity and the position-specific scoring matrix (PSSM) tool WebPSSM lacked specificity.
Raymond
Stéphanie
S
INSERM, U563, Toulouse F-31300, France.
Delobel
Pierre
P
Mavigner
Maud
M
Cazabat
Michelle
M
Souyris
Corinne
C
Encinas
Stéphanie
S
Sandres-Sauné
Karine
K
Pasquier
Christophe
C
Marchou
Bruno
B
Massip
Patrice
P
Izopet
Jacques
J
D000465:Algorithms; D005838:Genotype; D015699:HIV Envelope Protein gp120 / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D011991:Receptors, Virus; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA; D053585:Virus Attachment
D015699:HIV Envelope Protein gp120; D011991:Receptors, Virus; C514793:gp120 protein, Human immunodeficiency virus 1