The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise.
The importance of mitochondrial dysfunctions in the progression of chronic disease has been well established. Patients with chronic diseases are often prescribed a variety of medications, many of which have been shown to induce mitochondrial dysfunction. Exercise is a known stimulus for mitochondrial biogenesis and also recommended to patients as a lifestyle modification to supplement drug therapy. However, the potential interference of those drugs with mitochondrial adaptations to exercise has not been thoroughly investigated. This review provides a summary and discussion of known and potential interactions of commonly consumed drugs with exercise-induced mitochondrial adaptations.
Dept. of Health and Exercise Science, Colorado State Univ., 200 Moby B Complex, Fort Collins, CO 80523-1582, USA.
Matthew M
MM
Robinson
Karyn L
KL
Hamilton
Benjamin F
BF
Miller
D000222:Adaptation, Physiological / Q000502:physiology*; D000319:Adrenergic beta-Antagonists / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D004347:Drug Interactions / Q000502:physiology; D064420:Drug-Related Side Effects and Adverse Reactions / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000633:toxicity; D008931:Mitochondria, Muscle / Q000187:drug effects* / Q000378:metabolism; D028361:Mitochondrial Diseases / Q000139:chemically induced* / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors