Thymolipoma: clues to pathogenesis revealed by cytogenetics.
The pathogenesis of thymolipoma is controversial and unclear despite numerous reports. A case report of thymolipoma with cytogenetic analysis is herein presented. The lesion demonstrated a translocation involving the HMGA2 gene on chromosome 12q15, which is seen in two thirds of solitary lipomas. This finding supports the theory that this case of thymolipoma is a neoplasm of thymic fat.
Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, NJ 08903, USA. hudackra@umdnj.edu
Rachel
R
Hudacko
Hana
H
Aviv
John
J
Langenfeld
Billie
B
Fyfe
D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D025743:HMGA2 Protein / Q000235:genetics; D006801:Humans; D008067:Lipoma / Q000235:genetics* / Q000473:pathology*; D008479:Mediastinal Neoplasms / Q000235:genetics* / Q000473:pathology*; D013953:Thymus Neoplasms / Q000235:genetics* / Q000473:pathology*; D014178:Translocation, Genetic
D025743:HMGA2 Protein