Implant placement in patients with oral bisphosphonate therapy: a case series.
BACKGROUND
Although the effect of bisphosphonates on dental implant osseointegration is not clear, dental implant failures attributable to oral bisphosphonate therapy have been reported in patients with osteoporosis.


OBJECTIVE
The aim of this study was to evaluate implant survival in patients with a history of bisphosphonate therapy in a retrospective survey.


METHODS
A total of 46 ITI implants placed in 21 osteoporotic patients (females; average age 53 years, range 42-79 years) were evaluated with regard to probing depth, mobility, thread exposure, and bleeding on probing. All patients were under oral bisphosphonate therapy.


RESULTS
None of implants showed mobility and all patients could be considered free from peri-implantitis. Time of bisphosphonate therapy before and after implant insertion showed no statistically significant influence on PD, BOP, and TE. Likewise, implant location, prosthetic type, and opposing dentition had no statistically significant influence on the clinical and radiological parameters of implants.


CONCLUSIONS
Within the limitations of this study, it could be concluded that neither being on oral bisphosphonate treatment before implant placement nor starting bisphosphonate therapy after implant installation might jeopardize the successful osseointegration and clinical and radiographic condition of the implants.
Tehran University of Medical Science, Prosthodontics and Dental Research Center, Iran.
Ghasem Omati
GO
Shabestari
Yadollah Soleimani
YS
Shayesteh
Arash
A
Khojasteh
Marzieh
M
Alikhasi
Neda
N
Moslemi
Amin
A
Aminian
Reza
R
Masaeli
Behnam
B
Eslami
Nathaniel S
NS
Treister
D000328:Adult; D000368:Aged; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D016348:Osseointegration / Q000187:drug effects*; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D016019:Survival Analysis
D050071:Bone Density Conservation Agents; D015921:Dental Implants; D004164:Diphosphonates