Specifying mouse embryonic germ cells.
Male germ cells are induced to form from the epiblast of the mouse embryo by a combination of WNT and bone morphogenetic protein signals. Ohinata et al. (2009) now clarify the steps of mouse germ cell formation and use this genetic insight to direct the specification and differentiation of germline progenitor cells in vitro.
Children's Medical Research Institute, University of Sydney, Wentworthville, NSW, Australia. ptam@cmri.usyd.edu.au
Patrick P L
PP
Tam
David A F
DA
Loebel
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology; D004622:Embryo, Mammalian / Q000166:cytology / Q000196:embryology / Q000502:physiology; D005854:Germ Cells / Q000166:cytology* / Q000502:physiology; D008297:Male; D008648:Mesoderm / Q000166:cytology* / Q000502:physiology; D051379:Mice; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology; D051153:Wnt Proteins / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D051153:Wnt Proteins