Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?
The oxidative damage theory of aging once seemed almost proven. Yet recently the buzzards have been assembling in the blue skies above it. New challenges to the theory from work using nematode worms seem set to bring them down to peck at its bones. But is the theory really dead, or does it just need to be modified?
Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London, UK. david.gems@ucl.ac.uk
David
D
Gems
Ryan
R
Doonan
D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000378:metabolism; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D000072105:Superoxide Dismutase-1; D000099156:Superoxide Dismutase 2
D000975:Antioxidants; D002374:Catalase; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D000099156:Superoxide Dismutase 2