[Age changes redox regulation metabolism and antioxidative protection of neutrophils in patients with ischemic heart disease].
121 patients aged 35 to 85 years with ischemic heart disease (IHD) were observed. All the patients formed two age groups, mature and elderly. The 1st group consisted of women aged 35 to 55 years and men aged 35 to 60 years, the 2nd group of women aged 55+ years and men aged 60+ years. The group of control consisted of 47 patients aged 18 to 56 years without authentically verified IHD. 11 (9.1%) patients died of cardiovascular reasons within one year from the moment of hospitalisation. All of them (middle age 71.4 +/- 7.4 years) were the patients of elderly age grouP. The regression analysis showed that among various parameters (increase level of protein in urine, urea, creatinine, IL-6 and von Willebrand factor in blood, heart contraction rate), the growth of level of myeloperoxidase accompanied by activity reduction of glutathione reductase in neutrophils has also been connected with the increase of lethal outcome risk. Besides in elderly patients unlike patients of mature age in the beginning of hospitalisation a decrease in antioxidative protection activity (catalase) in neutrophils accompanied by an increase in IL-6 contents in blood not depended on presence diabetes mellitus type II and not connected with systolic dysfunction of heart left ventricle was found. It is possible to believe, that oppression antioxidative protection of neutrophils coming in process of ageing of an organism promotes in the conditions of stress uncontrollable manufacture reactive forms of oxygen damaging endothelium and breaking hemostasis, which results in death.
Kratnov
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D005980:Glutathione Reductase / Q000097:blood; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000503:physiopathology*; D009504:Neutrophils / Q000502:physiology*; D009195:Peroxidase / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D014841:von Willebrand Factor / Q000378:metabolism
D000975:Antioxidants; D015850:Interleukin-6; D014841:von Willebrand Factor; D003404:Creatinine; D002374:Catalase; D009195:Peroxidase; D005980:Glutathione Reductase