Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in patients with panic disorder during a verbal fluency task: near-infrared spectroscopy study.
We examined the relationship between the catechol-O-methyltransferase (COMT) Val158Met genotype and frontal lobe function by using multi-channel near-infrared spectroscopy (NIRS). The present study investigated oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin concentration changes during the performance of a verbal fluency task in the frontal region of 71 patients with panic disorder (PD). The activation of [oxy-Hb] on the right lateral prefrontal cortex was observed in the Met/Met genotype of the COMT gene polymorphism of PD patient groups in the analysis of NIRS, which seems to be related to the autonomic dysfunction in the pathogenesis of PD.
Department of Psychiatry, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan. h-tanii@clin.medic.mie-u.ac.jp
Hisashi
H
Tanii
Yukika
Y
Nishimura
Ken
K
Inoue
Hiroyuki
H
Koshimizu
Ryusuke
R
Matsumoto
Tetsuhei
T
Takami
Naomi
N
Hara
Atsushi
A
Nishida
Motohiro
M
Okada
Hisanobu
H
Kaiya
Yuji
Y
Okazaki
D000328:Adult; D001931:Brain Mapping; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D007839:Functional Laterality / Q000235:genetics; D005838:Genotype; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D009483:Neuropsychological Tests; D016584:Panic Disorder / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics; D017397:Prefrontal Cortex / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D014633:Valine / Q000235:genetics*; D014705:Verbal Behavior / Q000502:physiology*; D055815:Young Adult
D006454:Hemoglobins; D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine