Bilateral anterior granulomatous keratouveitis with sunset glow fundus in a patient with autoimmune polyglandular syndrome.
OBJECTIVE
To report the case of a patient with bilateral anterior granulomatous keratouveitis and sunset glow fundus.


METHODS
Review of case record.


RESULTS
A 15-year-old patient had bilateral anterior granulomatous keratouveitis and sunset glow fundus similar to findings in Vogt-Koyanagi-Harada disease (VKH). However, the patient also suffered additional autoimmune disease against endocrine glands. In addition to anti-thyroid antibody and anti-glutamic acid decarboxylase antibody, anti-melanocyte autoantibody was detected in serum from this patient. The authors finally diagnosed autoimmune polyglandular syndrome.


CONCLUSIONS
If resistance against treatment exists for VKH, particularly in pediatric cases, this disease should be considered and other endocrine disorders examined.
Department of Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.
Yuri
Y
Futagami
Sunao
S
Sugita
Takuro
T
Fujimaki
Toshiyuki
T
Yokoyama
Tomohiro
T
Morio
Manabu
M
Mochizuki
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D005260:Female; D005654:Fundus Oculi; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007634:Keratitis / Q000150:complications* / Q000473:pathology*; D008544:Melanocytes / Q000276:immunology; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology; D014605:Uveitis / Q000150:complications* / Q000473:pathology*; D014607:Uveomeningoencephalitic Syndrome / Q000473:pathology
D001323:Autoantibodies; D005968:Glutamate Decarboxylase