Does glucose infusion exacerbate metformin-associated lactate acidosis? A case report.
Metformin-associated lactate acidosis is a rare, but life-threatening complication of a widely prescribed medication. We describe here a case of metformin-associated lactate acidosis that rapidly deteriorated probably as a consequence of concomitant glucose infusion that was initiated to correct sulphonylurea-induced hypoglycemia.
Department of Medicine and Endocrinology, Maastricht University Medical Centre, Maastricht, The Netherlands. martijn.brouwers@intmed.unimaas.nl
M C G J
MC
Brouwers
N
N
Schaper
L
L
Keeris
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000628:therapy; D058186:Acute Kidney Injury / Q000139:chemically induced; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006440:Hemofiltration; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D008687:Metformin / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D006435:Renal Dialysis; D016896:Treatment Outcome
D007004:Hypoglycemic Agents; D008687:Metformin