The pulmonary toxicity of multi-wall carbon nanotubes in mice 30 and 60 days after inhalation exposure.
The pulmonary toxicity, induced by multi-wall carbon nanotubes in mice, was studied after 30-day and 60-day inhalation exposure. The mice were exposed to multi-wall carbon nanotubes aerosol with weighted mean concentration of 32.61 mg/m3, once in very two days, 6 hours in an exposure day. After 30-day and 60-day inhalation exposure, the pulmonary toxicity of multi-wall carbon nanotubes was assessed using biochemical indices in bronchoalveolar lavage fluid and pathological examination. It was found that the aerosolized multi-wall carbon nanotubes did not induce obvious pulmonary toxicity in 30-day exposure group, but induced severe pulmonary toxicity in 60-day exposure group.
Li
J G
JG
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
Li
Q N
QN
Xu
J Y
JY
Cai
X Q
XQ
Liu
R L
RL
Li
Y J
YJ
Ma
J F
JF
Li
W X
WX
D000336:Aerosols; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D005260:Female; D019570:Inhalation Exposure; D008168:Lung / Q000187:drug effects*; D051379:Mice; D037742:Nanotubes, Carbon / Q000633:toxicity*
D000336:Aerosols; D037742:Nanotubes, Carbon