Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis.
Human papillomavirus (HPV) is small, double-stranded DNA virus that infects mucosal and cutaneous epithelial tissue. HPV is sexually transmitted and the viral DNA replicates extrachromosomally. The virus is non-enveloped and has an icosahedral capsid. There are approximately 118 types of HPV, which are characterized as high-risk or low- risk types. High-risk HPVs cause malignant transformation while the low-risk ones cause benign warts and lesions. The expression of E6 and E7 is normally controlled during the normal viral life cycle when viral DNA replicates extrachromosomally. HPV E6 and E7 oncoproteins are overexpressed when the viral genome integrates into the host DNA.Deregulated overexpression of E6 and E7 oncoproteins can cause several changes in cellular pathways and functions leading to malignant transformation of cells and tumorigenesis. In this review, we focus on several cellular mechanisms and pathways that are altered in the presence of E6 and E7, the target proteins of E6 and E7 inside the host cell and how they contribute to the development of the transformed phenotype.
Ganguly
Niladri
N
International Centre for Genetic Engineering and Biotechnology, University of Cape Town, Cape Town, South Africa. toniladri@gmail.com
Parihar
Suraj P
SP
D052685:Alphapapillomavirus / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D002472:Cell Transformation, Viral; D006801:Humans; D008954:Models, Biological; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D030361:Papillomavirus Infections / Q000378:metabolism / Q000821:virology; D012307:Risk Factors; D014779:Virus Replication
D009856:Oncogene Proteins, Viral