An efficient preparation of N-alkyl-2-benzazepine derivatives and investigation of their biological activity.
N-Alkyl-2-benzazepine derivatives are readily prepared through N-alkylation of secondary 2-benzazepines that are constructed via 7-endo selective cyclization of radical cyclization of N-boc-N-(2-bromo-5-methoxyphenylmethyl) methacrylamides. The structure and activity relationship of these derivatives are examined.
Kamimura
Akio
A
Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8611, Japan. ak10@yamaguchi-u.ac.jp
So
Masahiro
M
Kuratani
Tomohiro
T
Matsuura
Kenji
K
Inui
Makoto
M
D000178:Acrylamides; D000478:Alkylation; D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects*; D003500:Cyclization; D004847:Epithelial Cells / Q000187:drug effects; D006801:Humans; D012867:Skin / Q000166:cytology; D013329:Structure-Activity Relationship; D014945:Wound Healing / Q000187:drug effects
D000178:Acrylamides; D001552:Benzazepines; C045985:methacrylamide