HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection.
OBJECTIVE
To evaluate HAb18G/CD147 as a cancer-associated biomarker using its monoclonal antibody HAb18.


RESULTS
On immunohistochemical analysis of 28 tissue microarrays and pathological sections of 1117 breast tissue samples, HAb18G/CD147 was expressed in carcinoma with an overall positivity rate of 67.76%, which was significantly higher than that in sarcomas (27.34%, P < 0.0001) and normal epithelial (5.18%, P < 0.0001) and fetal (2.67%, P < 0.0001) tissues. In epithelial tissues from 14 organs, the difference in HAb18G/CD147 expression between normal epithelium and the corresponding carcinoma was also significant (P < 0.05 for each pair). This expression in carcinoma was also found at the mRNA level, suggesting transcriptional level regulation of HAb18G/CD147 expression. In a retrospective study of 106 patients with infiltrating ductal carcinoma of the breast, the level of HAb18G/CD147 expression was positively correlated with tumour recurrence/metastasis (P = 0.0003) and negatively correlated with survival of breast cancer patients (P = 0.002). Multivariable Cox regression analysis showed that HAb18G/CD147 was an independent prognostic factor.


CONCLUSIONS
HAb18G/CD147 is significantly expressed in various cancers and appears to have prognostic significance, rendering it a possible cancer-associated biomarker for pathological diagnosis, prognostic evaluation, targeted therapy and radioimmunoimaging of a broad range of cancer types.
Li
Yu
Y
Cell Engineering Research Centre, Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, China.
Xu
Jing
J
Chen
Ling
L
Chen
Li
L
Zhong
Wei-De
WD
Zhang
Zheng
Z
Mi
Li
L
Zhang
Yang
Y
Liao
Cheng-Gong
CG
Bian
Hui-Jie
HJ
Jiang
Jian-Li
JL
Yang
Xiang-Min
XM
Li
Xiao-Yan
XY
Fan
Chun-Mei
CM
Zhu
Ping
P
Fu
Li
L
Chen
Zhi-Nan
ZN
D051926:Basigin / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness / Q000473:pathology; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D012189:Retrospective Studies
D014408:Biomarkers, Tumor; D051926:Basigin