Identification of carriers of the mutation causing coagulation factor XI deficiency in Polish Holstein-Friesian cattle.
Factor XI (FXI) deficiency is a hereditary coagulation disorder observed in various mammalian species. The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene. Because the disorder seems to have an impact on reproductive traits and udder health in cattle, we tested 103 randomly selected cows, 28 cows with repeat breeding, and 9 cows with recurrent mastitis for the presence of an abnormal FXI allele. Three related cows were diagnosed as carriers.
Department of Animal Immuno- and Cytogenetics, National Research Institute of Animal Production, Balice, Poland. arturgurgul@wp.pl
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Rubis
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D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics*; D005172:Factor XI / Q000235:genetics*; D005173:Factor XI Deficiency / Q000235:genetics / Q000662:veterinary*; D008969:Molecular Sequence Data; D009154:Mutation
D005172:Factor XI