Magnetic molecularly imprinted polymer for aspirin recognition and controlled release.
Core-shell structural magnetic molecularly imprinted polymers (magnetic MIPs) with combined properties of molecular recognition and controlled release were prepared and characterized. Magnetic MIPs were synthesized by the co-polymerization of methacrylic acid (MAA) and trimethylolpropane trimethacrylate (TRIM) around aspirin (ASP) at the surface of double-bond-functionalized Fe(3)O(4) nanoparticles in chloroform. The obtained spherical magnetic MIPs with diameters of about 500 nm had obvious superparamagnetism and could be separated quickly by an external magnetic field. Binding experiments were carried out to evaluate the properties of magnetic MIPs and magnetic non-molecularly imprinted polymers (magnetic NIPs). The results demonstrated that the magnetic MIPs had high adsorption capacity and selectivity to ASP. Moreover, release profiles and release rate of ASP from the ASP-loaded magnetic MIPs indicated that the magnetic MIPs also had potential applications in drug controlled release.
State Key Laboratory of Coordination Chemistry, MOE Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093, People's Republic of China.
Xianwen
X
Kan
Zhirong
Z
Geng
Yao
Y
Zhao
Zhilin
Z
Wang
Jun-Jie
JJ
Zhu
D001241:Aspirin / Q000378:metabolism*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000378:metabolism*; D008280:Magnetics; D008689:Methacrylates / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000378:metabolism*
D004337:Drug Carriers; D008689:Methacrylates; D011108:Polymers; C008384:methacrylic acid; D001241:Aspirin; C028643:trimethylolpropane trimethacrylate