Concise total synthesis of (+/-)-aspidospermidine via an oxidative Hosomi-Sakurai process.
A concise total synthesis of (+/-)-aspidospermidine has been achieved in twelve steps from inexpensive 4-ethylphenol, based on an oxidative Hosomi-Sakurai reaction via the concept of "aromatic ring umpolung".
Laboratoire de Méthodologie et Synthèse de Produits Naturels, Université du Québec à Montréal, Montréal, Québec, Canada.
Cyrille
C
Sabot
Kimiaka C
KC
Guérard
Sylvain
S
Canesi
D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D010084:Oxidation-Reduction; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
D026121:Indole Alkaloids; D010636:Phenols; D011804:Quinolines; C409672:aspidospermidine; C042291:4-ethylphenol