[Age dynamics of DNA damage, apoptosis and cell senescence in mice exposed to low dose gamma-irradiation in early development stages].
The analysis of age dynamics of mortality, body mass, DNA damages, apoptosis and cell senescence in mice irradiated by low dose rate gamma-rays (8 +/- 2 cGy) in early development stages have been carried out. It is displayed the increasing of DNA damage level in 8th and 11th months connected with decreasing of their sensitivity to apoptosis, elevation of mortality rate and drop of body mass after irradiation. Presented data are interpreted from a point of view of selection of non-repairable cells, which are not able to cope with low level of damages after irradiation in small doses.
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Veligzhaninov
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Moskalev
D000375:Aging / Q000502:physiology / Q000528:radiation effects*; D000818:Animals; D017209:Apoptosis / Q000502:physiology / Q000528:radiation effects*; D001835:Body Weight / Q000502:physiology / Q000528:radiation effects; D016922:Cellular Senescence / Q000502:physiology / Q000528:radiation effects*; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D018812:Paternal Exposure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012737:Sex Factors