Alpha-adrenergic activation upregulates expression of relaxin receptor RXFP1 in cardiomyocytes.
Cardiac RXFP1 was upregulated upon activation of the alpha(1)-adrenergic receptor (AR) through signal pathways involving protein kinase A and C and ERK. In contrast, beta(1)-AR activation downregulated expression of cardiac RXFP1 and it further counteracted the alpha(1)-AR-mediated RXFP1 upregulation.
Experimental Cardiology Laboratory, Baker Heart Research Institute, Melbourne, Australia. shirley.moore@baker.edu.au
Xiao-Lei
XL
Moore
Alice
A
Hong
Xiao-Jun
XJ
Du
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D005786:Gene Expression Regulation / Q000187:drug effects*; D007150:Immunohistochemistry; D051379:Mice; D008822:Mice, Transgenic; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000235:genetics / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism*; D018000:Receptors, Peptide / Q000235:genetics* / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; C478103:RXFP1 protein, mouse; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide; C504789:Rxfp1 protein, rat