Prospective open-label study of the administration of two-percent voriconazole eye drops.
Thirteen human subjects scheduled for elective anterior segment eye surgery received hourly 2% voriconazole eye drops 4 hours presurgery. No side effects were reported. Significantly, the voriconazole concentration in the aqueous humor of the eye was similar to that reported for the 1% voriconazole solution, suggestive of concentration-independent absorption.
Department of Pharmacy Practice, Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Daoud
D
Al-Badriyeh
Lok
L
Leung
Trent
T
Roydhouse
Robert
R
Fullinfaw
Mark
M
Daniell
Geoffrey E
GE
Davies
Kay
K
Stewart
David C M
DC
Kong
D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000737:chemistry; D005260:Female; D006801:Humans; D007634:Keratitis / Q000188:drug therapy* / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D011743:Pyrimidines / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D014230:Triazoles / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D009883:Ophthalmic Solutions; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole