Modulating the hybridization property of PNA with a peptoid-like side chain.
Modification on the gamma-N of the PNA backbone yielded a PNA analogue with a peptoid-like side chain. We found that the length of the side chain was important in influencing the hybridization affinity of the modified PNA.
Division of Chemical Biology and Biotechnology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
Xiao-Wei
XW
Lu
Yun
Y
Zeng
Chuan-Fa
CF
Liu
D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D034444:Peptoids / Q000737:chemistry*; D012689:Sequence Homology, Nucleic Acid; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D020135:Peptide Nucleic Acids; D034444:Peptoids; D009584:Nitrogen