Characteristics, formation, and pathophysiology of glucosepane: a major protein cross-link.
Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has been shown to accumulate in the extracellular matrix, where it cross-links collagen. Levels of glucosepane increase with aging. By increasing collagen stiffness, glucosepane cross-links may have significant implications in several age-related diseases, such as cardiovascular disease, diabetes, and osteoporosis. Although the formation pathways for glucosepane are relatively well researched, much is still unknown about the accumulation and pathophysiology of glucosepane.
Lund University, Lund, Sweden. johan.svantesson-sjoberg.748@student.lu.se
Johan Svantesson
JS
Sjöberg
Sven
S
Bulterijs
D000375:Aging / Q000378:metabolism; D000818:Animals; D003094:Collagen / Q000737:chemistry / Q000378:metabolism*; D003432:Cross-Linking Reagents / Q000378:metabolism*; D004194:Disease; D005947:Glucose / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000737:chemistry / Q000378:metabolism*; D006801:Humans
D003432:Cross-Linking Reagents; D017127:Glycation End Products, Advanced; C543060:glucosepane; D003094:Collagen; D005947:Glucose