Epidemiology of the complications of gastroesophageal reflux disease.
The complications of gastroesophageal reflux disease (GERD) include ulcers, strictures, Barrett's esophagus and carcinoma. Although the prevalence of GERD is very high, the development of complications remains quite rare and usually occurs in association with factors generally observed in more severe disease such as hiatal hernia, bile reflux or severely disturbed motility. Recent studies have emphasized the role of obesity and genetic factors as aggravating factors in the development of GERD complications. Barrett's esophagus is the most prevalent complication of GERD and seems to be associated with an increased mortality rate. However, cancer incidence is low and most patients die from other causes, especially cardiovascular disease.
Belhocine
Kafia
K
Institut des Maladies de l'Appareil Digestif Nantes, Université de Nantes, Nantes, France.
Galmiche
Jean-Paul
JP
D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology; D001471:Barrett Esophagus / Q000453:epidemiology / Q000209:etiology; D004032:Diet; D004935:Esophageal Diseases / Q000453:epidemiology* / Q000209:etiology*; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology; D004940:Esophageal Stenosis / Q000453:epidemiology / Q000209:etiology; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000473:pathology / Q000517:prevention & control; D006471:Gastrointestinal Hemorrhage / Q000453:epidemiology / Q000209:etiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D009765:Obesity / Q000150:complications; D012307:Risk Factors; D012720:Severity of Illness Index; D014456:Ulcer / Q000453:epidemiology / Q000209:etiology