Enhancement of chemically-induced HL-60 cell differentiation by 3,3'-diindolylmethane derivatives.
3,3'-Diindolylmethane (DIM, 1) and its derivatives have been prepared, and their enhancing effects on chemically-induced HL-60 cell differentiation were analyzed. Among the prepared compounds, IndDIM (12) showed the most potent enhancing effect on HL-60 cell differentiation induced by chemicals, including retinoids, 1,25-dihydroxyvitamin D(3), 12-O-tetradecanoyl phorbol-13-acetate and dimethyl sulfoxide.
Institute of Molecular & Cellular Biosciences, The University of Tokyo, Tokyo, Japan. noguchi@iam.u-tokyo.ac.jp
Tomomi
T
Noguchi-Yachide
Masashi
M
Tetsuhashi
Hiroshi
H
Aoyama
Yuichi
Y
Hashimoto
D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D045744:Cell Line, Tumor; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure
D016588:Anticarcinogenic Agents; D007211:Indoles; C016392:3,3'-diindolylmethane