Effects of 5-HT in globus pallidus on haloperidol-induced catalepsy in rats.
Histological, behavioral and electrophysiological studies have suggested that 5-HT may regulate motor function by affecting globus pallidus neurons activity. In this study, the effects of 5-HT in globus pallidus on haloperidol-induced catalepsy and its possible receptor mechanisms were examined in rats using bar tests. Bilateral microinjection of 5-HT (10microM) into globus pallidus significantly attenuated haloperidol-induced catalepsy. This anticataleptic effect was completely counteracted by selective 5-HT(1B) receptors antagonist SB-224289 (10microM), while partly reversed by selective 5-HT(4) receptors antagonist GR-113808 (1microM). In addition, the selective 5-HT(7) receptors antagonist SB-269970 (1microM) partly reversed the anticataleptic effect of 5-HT only at the incipient period after the intrapallidal injection. In conclusion, 5-HT in globus pallidus could attenuate haloperidol-induced catalepsy via multiple receptor mechanisms.
Wei
Lei
L
Department of Physiology, Qingdao University, Qingdao 266071, China.
Chen
Lei
L
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000633:toxicity; D005917:Globus Pallidus / Q000378:metabolism*; D006220:Haloperidol / Q000633:toxicity; D008297:Male; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000008:administration & dosage / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology
D018492:Dopamine Antagonists; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin; D006220:Haloperidol