[Expression and significance of basic fibroblast growth factor in infant vascular anomalies].
OBJECTIVE
To investigate the expression of basic fibroblast growth factor (bFGF) in infant's peripheral blood and tumor blood of vascular malformation and peripheral venous blood of hemangioma, and the possibility to differentiate hemangioma from vascular malformations by detecting bFGF level in peripheral blood.


METHODS
The level of bFGF in peripheral blood(49 vascular malformations ,32 hemangioma cases and 23 normal cases) and tumor blood(14 venous malformations) of infants was measured by ELISA.SPSS11.5 software package was used to analyze the data and student's t test and ANOVA were used to determine the difference between different groups.


RESULTS
The expression of bFGF in tumor blood from infants with venous malformations was significantly higher than that in peripheral blood (P<0.05); No significant difference of bFGF level in peripheral blood was found between hemangioma,vascular malformation and normal infants(P>0.05).


CONCLUSIONS
The level of bFGF in tumor blood of from infants with venous malformation was higher than that in peripheral blood; Examination of bFGF in peripheral blood can not differentiate hemangioma from vascular malformations.
College of Stomatology, Guangxi Medical University, Nanning 530021, China. luoli315@hotmail.com
Li
L
Luo
Hui
H
Huang
Da-Hai
DH
Yu
Xiao-Yi
XY
Hu
Xiao-Qiong
XQ
Hou
Xiao-Jie
XJ
Li
D016222:Fibroblast Growth Factor 2; D006391:Hemangioma; D006801:Humans; D007223:Infant
D016222:Fibroblast Growth Factor 2