Amyloid deposits: protection against toxic protein species?
Neurodegenerative diseases ranging from Alzheimer disease and polyglutamine diseases to transmissible spongiform encephalopathies are associated with the aggregation and accumulation of misfolded proteins. In several cases the intracellular and extracellular protein deposits contain a fibrillar protein species called amyloid. However while amyloid deposits are hallmarks of numerous neurodegenerative diseases, their actual role in disease progression remains unclear. Especially perplexing is the often poor correlation between these deposits and other markers of neurodegeneration. As a result the question remains whether amyloid deposits are the disease-causing species, the consequence of cellular disease pathology or even the result of a protective cellular response to misfolded protein species. Here we highlight studies that suggest that accumulation and sequestration of misfolded protein in amyloid inclusion bodies and plaques can serve a protective function. Furthermore, we discuss how exceeding the cellular capacity for protective deposition of misfolded proteins may contribute to the formation of toxic protein species.
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Sebastian
S
Treusch
Douglas M
DM
Cyr
Susan
S
Lindquist
D000544:Alzheimer Disease / Q000378:metabolism; D000682:Amyloid / Q000737:chemistry / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D019610:Cytoprotection; D006816:Huntington Disease / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D017096:Prion Diseases / Q000378:metabolism; D017510:Protein Folding; D011506:Proteins / Q000633:toxicity
D000682:Amyloid; D016229:Amyloid beta-Peptides; D018832:Molecular Chaperones; D011506:Proteins