Me-bipam for enantioselective ruthenium(II)-catalyzed arylation of aldehydes with arylboronic acids.
Ligand design by-pam: A ruthenium-catalyzed asymmetric arylation of aldehydes with arylboronic acids has been developed, giving chiral diarylmethanols in good yields. The use of a chiral bidentate phosphoramidite ligand ((R,R)-Me-bipam) led to excellent enantioselectivities.
Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan. yasuyama@eng.hokudai.ac.jp
Yasunori
Y
Yamamoto
Kazunori
K
Kurihara
Norio
N
Miyaura