Personality and the serotonin transporter gene: Associations in a longitudinal population-based study.
Associations between the promoter polymorphism of the serotonin transporter gene (5-HTTLPR) and anxiety-related personality traits in healthy adult subjects have been inconsistent. We assessed personality in participants of the Estonian Children Personality Behaviour and Health Study, using parental reports and self-reports. In the younger cohort, according to parental assessments at ages 9 and 15, children homozygous for the S allele had significantly higher scores of Neuroticism and lower scores of Openness, Agreeableness and Conscientiousness. Parental assessment of the older cohort at ages 15 and 18 did not yield any genotype effect on personality; however, interaction of cohort and genotype was not significant. According to self-reports, SS homozygotes had higher Neuroticism at age 15 but not at age 18. Thus, homozygocity for the S allele of the 5-HTTLPR is related to anxiety-related personality traits in general population, but this is easier to detect before adolescence.
Harro
Jaanus
J
Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi, Estonia. jaanus.harro@ut.ee
Merenäkk
Liis
L
Nordquist
Niklas
N
Konstabel
Kenn
K
Comasco
Erika
E
Oreland
Lars
L
D000293:Adolescent; D000367:Age Factors; D000704:Analysis of Variance; D001007:Anxiety; D002648:Child; D018672:Community Health Planning; D004957:Estonia; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory; D011110:Polymorphism, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
D050486:Serotonin Plasma Membrane Transport Proteins