Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract.
Primary human uterine, cervical, and ectocervical stromal fibroblasts constitutively secrete hepatocyte growth factor (HGF), yet only uterine stromal fibroblasts increase HGF secretion in response to estradiol. Estradiol-induced HGF secretion by uterine stromal fibroblasts may have a significant effect on uterine cancer and endometriosis.
Coleman
Kimberly D
KD
Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire. Electronic address: Kimberly.Coleman@dartmouth.edu.
Wright
Jacqueline A
JA
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Ghosh
Mimi
M
Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire.
Wira
Charles R
CR
Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire.
Fahey
John V
JV
Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire.
D000328:Adult; D000368:Aged; D002450:Cell Communication / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002584:Cervix Uteri / Q000166:cytology / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D004958:Estradiol / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D017228:Hepatocyte Growth Factor / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D014599:Uterus / Q000166:cytology / Q000378:metabolism*
D004958:Estradiol; D017228:Hepatocyte Growth Factor