Doppler sonographic analysis of synovial vascularization in a patient with rheumatoid arthritis treated with leukocytapheresis.
Synovial vascularization in metacarpophalangeal joints of a patient with rheumatoid arthritis treated with leukocytapheresis (LCAP) was evaluated by Doppler sonography. After the treatment with LCAP, evaluation with American College of Rheumatology core set showed improvement, and the levels of C-reactive protein and serum amyloid A protein decreased. Power Doppler sonography demonstrated a reduction of color flow signals of the joints, and spectral Doppler sonography demonstrated an increase in vascular resistant, indicating a reduction of vessel's permeability. This is the first report evaluating a synovial vascularization and blood flow of the joints by Doppler sonography before and after LCAP therapy. Doppler sonography might be one of the useful methods for evaluating the therapeutic response of LCAP.
The Second Department of Internal Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. ykanno@fmu.ac.jp
Yukiko
Y
Kanno
Hiroko
H
Kobayashi
Eiji
E
Suzuki
Haruyo
H
Iwadate
Tomomi
T
Sasajima
Hiroshi
H
Watanabe
Hiromasa
H
Ohira
D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007937:Leukapheresis; D008875:Middle Aged; D013583:Synovial Membrane / Q000098:blood supply* / Q000000981:diagnostic imaging; D018608:Ultrasonography, Doppler; D014655:Vascular Resistance