[Expression of IMP3 in osteosarcoma and its clinical significance].
OBJECTIVE
To analyze the expressional variability of IMP3 between osteosarcoma and osteochondroma and explore its clinical significance.


METHODS
Paraffin sections from 68 patients with osteosarcoma and 20 patients with osteochondroma were examined for the expression of IMP3 by SP immunohistochemistry.


RESULTS
The negative, weak positive, moderate positive and strong positive expression rates of IMP3 in 68 patients with osteosarcoma were 4.41% (3/68), 22.06% (15/68), 22.74% (19/68), 45.59% (31/68), respectively, which were significantly higher than those in 20 cases of osteochondroma tissues (P<0.01). The positive expression of IMP3 in osteosarcoma was negative correlation with the 3-year survival rate of osteosarcoma patients after the operation (P<0.01).


CONCLUSIONS
The results suggest that IMP3 plays important roles in the tumorigenesis, progress and prognosis of osteosarcoma, and the expression of IMP3 may be an important feature of osteosarcoma.
Department of Orthopaedics of Xiangya Hospital, Central South University, Changsha, China.
Kang-hua
KH
Li
Yue-ping
YP
Huang
Jun
J
Zhang
Guo-jun
GJ
Li
Si-hong
SH
Li
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D016015:Logistic Models; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D015831:Osteochondroma / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D012516:Osteosarcoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000096:biosynthesis*; D015996:Survival Rate; D055815:Young Adult
C498780:IGF2BP3 protein, human; D009363:Neoplasm Proteins; D016601:RNA-Binding Proteins