Non-toxicity of IV injected perfluorocarbon oxygen carrier in an animal model of liver regeneration following surgical injury.
Lethal dose experiments in animals have demonstrated that second-generation perfluorocarbon oxygen carriers are remarkably non-toxic. However, this non-toxicity has not previously been demonstrated in a liver failure scenario. A surgical liver damage and regeneration model in rats was selected using a well-controlled cross tabulated study design. A large number of physiological, biochemical, and hematological parameters were measured. No indications were found that intravenously injected perfluorooctyl bromide emulsion was toxic at the concentrations employed, in either healthy or severe liver injury scenarios. Neither was there any significant impact on the rate of liver regeneration following the injuries. Bearing in mind prior human clinical studies, it is therefore safe to assume that perfluorocarbon emulsions are also non-toxic in bioartificial liver treatments.
Hepatology Research Unit, University of Pretoria, South Africa. martin.nieuwoudt@up.ac.za
Martin
M
Nieuwoudt
Gert H C
GH
Engelbrecht
Lebo
L
Sentle
Roland
R
Auer
Del
D
Kahn
Schalk W
SW
van der Merwe
D000328:Adult; D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage* / Q000633:toxicity*; D002626:Chemistry, Pharmaceutical; D004195:Disease Models, Animal; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage* / Q000633:toxicity*; D006405:Hematology; D006801:Humans; D007275:Injections, Intravenous; D007431:Intraoperative Complications / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D008115:Liver Regeneration / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001802:Blood Substitutes; D005466:Fluorocarbons