An optical approach for drug screening based on light-harvesting conjugated polyelectrolytes.
Drugs turn the light off: Conjugated polyelectrolytes (CPEs) have been used in fluorescent assays for real-time screening of small molecules that prevent the RNA-protein complexation that is important for virus replication and thereby can be considered potential initial candidates for drug discovery (see picture).
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, PR China.
Lingling
L
An
Libing
L
Liu
Shu
S
Wang
Guillermo C
GC
Bazan
D004353:Drug Evaluation, Preclinical; D004573:Electrolytes / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry; D005601:Framycetin / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D004573:Electrolytes; D005456:Fluorescent Dyes; D010455:Peptides; D005601:Framycetin; D012313:RNA