Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitus.
Individuals with type 2 diabetes mellitus (DM) characteristically have elevated fasting and postprandial (PP) plasma triglycerides (TG). Previous case-control studies indicated that PPTG levels predict the presence of coronary artery disease (CAD) in people without DM; however, the data for patients with DM are conflicting. Therefore, we conducted a case-control study in DM individuals, 84 with (+) and 80 without (-) CAD. Our hypothesis was that DM individuals with or without CAD would have similar PPTG levels, but CAD+ individuals would have more small d<1.006 g/L lipoprotein particles. Several markers of PP lipid metabolism were measured over 10 h after a fat load. PP lipoprotein size and particle number were also determined. There was no significant difference in any measure of PP lipid metabolism between CAD+ and CAD-, except for apoB48, which was actually higher in CAD-. We followed 69 CAD- participants for a mean 8.7 years; 33 remained free of any cardiovascular event. There were no PP differences at baseline between these 33 who remained CAD- and either the 36 original CAD- who subsequently developed CAD or the original CAD+ group.PP measurements of TG-rich lipoproteins do not predict the presence of CAD in individuals with DM.
Departments of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Gissette
G
Reyes-Soffer
Steve
S
Holleran
Wahida
W
Karmally
Colleen I
CI
Ngai
Niem-Tzu
NT
Chen
Margarita
M
Torres
Rajasekhar
R
Ramakrishnan
William S
WS
Blaner
Lars
L
Berglund
Henry N
HN
Ginsberg
Catherine
C
Tuck
D000328:Adult; D000368:Aged; D053283:Apolipoprotein B-48 / Q000097:blood; D050197:Atherosclerosis / Q000150:complications; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications* / Q000453:epidemiology; D005215:Fasting; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D053283:Apolipoprotein B-48; D008074:Lipoproteins; D014280:Triglycerides; C112017:remnant-like particle cholesterol; D002784:Cholesterol