First trimester maternal serum placental protein 13 for the prediction of pre-eclampsia in women with a priori high risk.
OBJECTIVE
To evaluate whether first trimester maternal serum PP13 can predict pre-eclampsia among women with a priori high risk.


METHODS
This was a nested case-control study. Women less than 14 weeks' gestation at increased risk of developing pre-eclampsia were recruited. Venous blood samples were assayed for PP13 using enzyme-linked immunosorbent assay. PP13 multiples of median (MoM) were calculated and adjusted for body mass index, ethnicity, smoking, maternal age and parity. For each case of pre-eclampsia (n = 42), five controls were randomly selected. PP13 levels were compared between women who developed pre-eclampsia and controls using the Wilcoxon rank sum test. Sensitivity and false-positive rates were derived from receiver operating characteristic curves.


RESULTS
Women who developed pre-eclampsia had significantly lower (P < 0.001) PP13 MoMs compared with controls. PP13 MoMs for controls and pre-eclampsia cases were 1.0 (range 0.0-10.0) and 0.4 (range 0.0-7.0), respectively (P < 0.001). At a MoM cutoff of 0.53, for a false-positive rate of 10%, sensitivity was 50% for pre-eclampsia at term (>37 weeks), 62% for preterm pre-eclampsia (<37 weeks) and 71% for early-onset pre-eclampsia (<34 weeks).


CONCLUSIONS
First trimester PP13 can predict pre-eclampsia in women at increased a priori risk and predicts early-onset better than late-onset disease.
Department of Obstetrics & Gynaecology, Queen Mary, University of London, UK. asmakhalil79@googlemail.com
Asma
A
Khalil
Nicholas J
NJ
Cowans
Kevin
K
Spencer
Sergey
S
Goichman
Hamutal
H
Meiri
Kevin
K
Harrington
D000328:Adult; D001724:Birth Weight; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D037161:Galectins / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011257:Pregnancy Proteins / Q000097:blood*; D011261:Pregnancy Trimester, First / Q000097:blood* / Q000502:physiology; D018566:Pregnancy, High-Risk / Q000097:blood* / Q000502:physiology
D037161:Galectins; C038195:LGALS13 protein, human; D011257:Pregnancy Proteins