Concentrations of organohalogen compounds and titres of antibodies to Epstein-Barr virus antigens and the risk for non-Hodgkin lymphoma.
Exposure to some pesticides and persistent organic pollutants (POPs) has been indicated to be a risk factor for non-Hodgkin's lymphoma (NHL). Epstein-Barr virus (EBV) has been associated with some subgroups of NHL. In a previous study we found an interaction between high concentrations of some POPs and titres of antibodies to EBV early antigen (EA IgG) in relation to NHL. In the present study we measured lipid adjusted plasma concentrations of 35 congeners of polychlorinated biphenyls (PCB), p,p'-dichlorodiphenyldichloroethyelene (p,p'-DDE), hexachlorobenzene (HCB), seven subgroups of chlordanes (cis-heptachlorepoxide, cis-chlordane, trans-chlordane, oxychlordane, MC6, trans-nonachlordane, cis-nonachlordane) and one polybrominated diphenylether (PBDE) congener (no. 47) in 99 cases with NHL and 99 population based controls. Odds ratios (OR) for NHL were estimated. Sum of PCBs > median in the controls gave odds ratio (OR) 2.0, 95% confidence interval (CI) 0.99-3.9. High sum of chlordanes yielded OR 2.3, 95% CI 1.2-4.5. An interaction with EBV EA IgG was found. High sum of PCB gave OR 5.2, 95% CI 1.9-14 in the group with EA IgG > 40. Similarly HCB yielded OR 5.3, 95% CI 1.9-15, pp'-DDE gave OR 3.3, 95% CI 1.4-7.7 and sum of chlordanes yielded OR 6.8, 95% CI 2.3-20, whereas no association was found with PBDE. In summary, this study confirmed an association between certain POPs and NHL with an interaction with titre of IgG antibody to EBV EA.
MTM Research Centre, School of Science and Technology, Orebro University, SE-701 82 Orebro, Sweden.
Karin
K
Hardell
Michael
M
Carlberg
Lennart
L
Hardell
Helén
H
Björnfoth
Ingrid
I
Ericson Jogsten
Mikael
M
Eriksson
Bert
B
Van Bavel
Gunilla
G
Lindström
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000276:immunology; D036022:Capsid Proteins / Q000276:immunology; D016022:Case-Control Studies; D004785:Environmental Pollutants / Q000009:adverse effects / Q000097:blood*; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000009:adverse effects / Q000097:blood*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced / Q000209:etiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011159:Population Surveillance; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult
D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D004785:Environmental Pollutants; C041788:Epstein-Barr viral capsid antigen; C033305:Epstein-Barr virus early antigen; D055768:Halogenated Diphenyl Ethers; D006843:Hydrocarbons, Chlorinated; D007074:Immunoglobulin G