Comparison between laser therapy and non-surgical therapy for periodontitis in rats treated with dexamethasone.
The aim of this study was to compare low-level laser therapy (LLLT) as adjuvant treatment for induced periodontitis with scaling and root planing (SRP) in dexamethasone-treated rats. One-hundred twenty rats were divided into groups: D group (n = 60), treated with dexamethasone; ND group (n = 60) treated with saline solution. In both groups, periodontal disease was induced by ligature at the left first mandibular molar. After 7 days, the ligature was removed and all animals were subjected to SRP and were divided according to the following treatments: SRP, irrigation with saline solution (SS); SRP + LLLT, SS and laser irradiation (660 nm; 24 J; 0.428 W/cm(2)). Ten animals in each treatment were killed after 7 days, 15 days and 30 days. The radiographic and histometric values were statistically analyzed. In all groups radiographic and histometric analysis showed less bone loss (P < 0.05) in animals treated with SRP + LLLT in all experimental periods. SRP + LLLT was an effective adjuvant conventional treatment for periodontitis in rats treated with dexamethasone.
Garcia
Valdir Gouveia
VG
Department of Surgery and Integrated Clinic, Division of Periodontics, São Paulo State University (UNESP), Rua Jose Bonifácio 1193, Centro, 16050-300 Araçatuba, SP, Brasil. vg.garcia@uol.com.br
Fernandes
Leandro Araújo
LA
de Almeida
Juliano Milanezi
JM
Bosco
Alvaro Francisco
AF
Nagata
Maria José Hitomi
MJ
Martins
Thiago Marchi
TM
Okamoto
Tetuo
T
Theodoro
Leticia Helena
LH
D016301:Alveolar Bone Loss / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy; D000818:Animals; D003131:Combined Modality Therapy; D012534:Dental Scaling; D003907:Dexamethasone / Q000633:toxicity; D028022:Low-Level Light Therapy; D008297:Male; D010518:Periodontitis / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy; D051381:Rats; D017208:Rats, Wistar; D016745:Root Planing
D003907:Dexamethasone