Allogeneic memory T cell response.
Recent data have revealed marked differences in alloresponses mediated by memory T cells during GVH and host-versus-graft (HVG) reactions (summarized in Table 1). Even though the mechanisms are not completely understood, it is clear that all memory T cells including nonallospecific, crossreactive, and allospecific memory T cells have decreased ability to induce GVHD. Selection of memory T cells or removal of naïve T cells will not only prevent GVHD, but could also enhance immune reconstitution, facilitate engraftment, and have the potential to enhance antitumor effects. A clinical trial has been planned. Successful translation of this approach in the clinic will improve the safety, enhance the effectiveness, and broaden the scope of allogeneic hematopoietic stem cell transplantation.
Chen
Benny J
BJ
Division of Cellular Therapy/BMT, Duke University Medical Center, Durham, North Carolina, USA.
D000818:Animals; D006086:Graft vs Host Disease / Q000517:prevention & control; D006087:Graft vs Host Reaction / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006789:Host vs Graft Reaction / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation