[Insulin-resistance and metabolic syndrome in patients with coronary heart disease defined by angiography].
The frequency of insulin-resistance (IR) and metabolic syndrome (MS) were examined in coronary patients using different criteria of definition. It was also analyzed which of them indicated a strong association with the presence and severity of the disease. This was a case-control study on 100 patients between 40 and 70 years old, assisted in a hospital center and there examined by angiography. IR was defined by insulin >15 mU/l, Homeostatic Model Assessment for insulin-resistance (HOMA-IR) >3.1 and the combination body mass index (BMI) >27.5 kg/m2 with HOMA-IR >3.6. MS was defined according to International Diabetes Federation and American Heart Association/National Heart, Lung and Blood Institute. Insulin >15 mU/l and HOMA-IR >3.1 had similar sensibility, 60.3%, and were significantly associated with the extension of coronary heart disease, p = 0.001 and p = 0.009 respectively. Whereas, BMI>27.5 kg/m2 with HOMA-IR>3.6 showed a lower sensibility, 43.1% and less association with severity, p = 0.028. The odds ratio (OR) for coronary heart disease were respectively: 3.16 (CI 95 1.28-7.79), p = 0.012; 2.93 (CI 95% 1.20-7.19) p = 0.019; 2.86 (CI 95% 1.10-7.41), p = 0.031. The frequency of SM defined according to American Heart Association/National Heart, Lung and Blood Institute was higher in coronary patients vs. controls (62.1% vs. 33.3%, p = 0.003). It was associated with disease in one or more vases (p = 0.011) and was its predictor, OR = 4.22 (CI 95% 1.65-10.83) p = 0.003. However, SM defined according to International Diabetes Federation was not associated with the presence or severity of coronary heart disease.
Benozzi
Silvia
S
Cátedra de Análisis Clínicos, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur.
Ordoñez
Fernando
F
Polini
Nélida
N
Alvarez
Cristina
C
Sellés
Juana
J
Coniglio
Raúl I
RI
D000328:Adult; D000368:Aged; D001118:Argentina / Q000453:epidemiology; D015992:Body Mass Index; D016022:Case-Control Studies; D017023:Coronary Angiography; D003327:Coronary Disease / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D012720:Severity of Illness Index; D012737:Sex Factors