Antiepileptic drugs: are women aware of interactions with oral contraceptives and potential teratogenicity?
Women with epilepsy (WWE)'s knowledge of the interaction between antiepileptic drugs (AEDs) and oral contraceptives (OCs) and the potential teratogenicity of AEDs has received limited study. We conducted a cross-sectional questionnaire study (English or Spanish) among young WWE (18-44 years) to assess demographic characteristics, current AED use, and knowledge of AED interactions with OCs and teratogenicity. We used the Food and Drug Administration's classification system to categorize each AED's teratogenic potential. Participants (n=148) had a mean age of 32 years (SD 8); 32% spoke Spanish and described themselves as Hispanic. Among women prescribed a cytochrome p450-inducing AED, 65% were unaware of decreased OC efficacy. Forty percent of those prescribed Category D AEDs were unaware of potential teratogenic effects. WWE have limited knowledge of the potential interaction between AEDs and OCs and the teratogenic effects of AEDs. Educational efforts should highlight the reproductive health effects of AEDs in WWE.
Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
Alison M
AM
Pack
Anne R
AR
Davis
Jordana
J
Kritzer
Ava
A
Yoon
Adela
A
Camus
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001364:Awareness; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D004347:Drug Interactions / Q000502:physiology; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D011247:Pregnancy; D011795:Surveys and Questionnaires; D055815:Young Adult
D000927:Anticonvulsants; D003276:Contraceptives, Oral