Glucocorticosteroids associated with a decreased risk of psychosis.
The hypothesis that chronic inflammation may play a role in psychosis receives increasing attention. In this study, we aim to investigate whether the use of steroidal anti-inflammatory drugs is associated with a decreased risk of psychosis.A longitudinal nested case-control study was performed investigating the association of glucocorticosteroid (GCS) consumption with a new diagnosis of a psychotic disorder. Significantly reduced odds ratios of 0.52 (95% confidence interval, 0.36-0.75) were found for GCS in men only (odds ratio in women, 0.84 [95% confidence interval, 0.590-1.20]). Similar risk reductions were present for the inhaled and systemic GCSs. A dose-response relationship was present. Our finding of an inverse relation between GCS consumption and new psychotic episodes may promote further research into inflammation in schizophrenia.
Laan
Wijnand
W
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. W.Laan@umcutrecht.nl
Smeets
Hugo
H
de Wit
Niek J
NJ
Kahn
René S
RS
Grobbee
Diederick E
DE
Burger
Huibert
H
D000280:Administration, Inhalation; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016022:Case-Control Studies; D002908:Chronic Disease; D016208:Databases, Factual; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000188:drug therapy; D008137:Longitudinal Studies; D008297:Male; D016017:Odds Ratio; D011618:Psychotic Disorders / Q000209:etiology / Q000517:prevention & control*; D012737:Sex Factors
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids