Diagnostic performance of the cytomegalovirus (CMV) antigenemia assay in patients with CMV gastrointestinal disease.
Of 149 patients with suspected cytomegalovirus (CMV) gastrointestinal disease, 51 (36%) confirmed cases, 6 (4%) probable cases, and 64 (45%) instances of non-CMV gastrointestinal disease were analyzed using the CMV antigenemia assay; 22 patients (5%) with indeterminate gastrointestinal disease were excluded. The sensitivity and specificity of the CMV antigenemia assay (defined as detection of > or =1 positive cells per 200,000 leukocytes) for diagnosis of CMV gastrointestinal disease were 54% (95% confidence interval, 41%-68%) and 88% (95% confidence interval, 77%-94%), respectively.
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
Eun-Young
EY
Jang
Seong Yeon
SY
Park
Eun Jung
EJ
Lee
Eun Hee
EH
Song
Yong Pill
YP
Chong
Sang-Oh
SO
Lee
Sang-Ho
SH
Choi
Jun Hee
JH
Woo
Yang Soo
YS
Kim
Sung-Han
SH
Kim
D000328:Adult; D000368:Aged; D000956:Antigens, Viral / Q000097:blood*; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D005260:Female; D005767:Gastrointestinal Diseases / Q000821:virology*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D012680:Sensitivity and Specificity
D000956:Antigens, Viral