SELDI protein chip technology for the detection of serum biomarkers for liver disease.
The need to identify disease biomarkers is critical to ensure fast diagnosis and timely treatment. Surface enhanced laser desorption/ionization time-of-fight mass spectrometry (SELDI-TOF-MS) is a widely used technology platform for diagnostic biomarker discovery. This short review provides an overview of how it functions and also describes its advantages and drawbacks.
Chen
Lei
L
Department of Hepatobiliary Surgery, Peking University People's Hospital, 11 Xizhimen South Street,Beijing, China. chentiger@medmail.com.cn
Fatima
Sarwat
S
Peng
Jirun
J
Leng
Xisheng
X
D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods*; D013499:Surface Properties
D015415:Biomarkers