[Change of serum MCP-1 level and CCR2 protein expression in isolated monocytes in patients with acute coronary syndrome].
OBJECTIVE
To investigate the change of serum MCP-1 level and CCR2 expression in isolated monocytes in patients with acute coronary syndrome (ACS) and its possible relationship with ACS pathogenesis.


METHODS
Thirty ACS patients and 30 healthy controls were enrolled. Serum MCP-1 levels were determined by ELISA in all subjects. The protein expression of CCR2 in isolated monocytes was assessed by flow cytometry.


RESULTS
Serum MCP-1 concentrations in ACS patients were higher than those in healthy controls (P<0.05) and the ratio of CCR2 protein expression in monocytes in ACS patients was higher than that in healthy controls (P<0.01).


CONCLUSIONS
The serum MCP-1 concentrations and protein expression of CCR2 in ACS patients are significantly higher than those in healthy controls, which might be associated with the pathogenesis of ACS.
Department of Gerontology, Hunan Provincial Peopleos Hospital, Changsha 410001, China. zhangmingkui001@yahoo.com.cn
Yangui
Y
Wang
Zhaoqian
Z
Liu
Tianlun
T
Yang
D054058:Acute Coronary Syndrome / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D054390:Receptors, CCR2 / Q000097:blood*
C111835:CCL2 protein, human; C515334:CCR2 protein, human; D018932:Chemokine CCL2; D054390:Receptors, CCR2