[Keratomycosis: diagnosis and therapy].
Diagnosis of fungal keratitis is only straightforward if it presents in its typical form with pyramidal-shaped hypopyon, prominent geographical corneal infiltration and satellites. However, in contact-lens wearers clinical presentation is untypical at early infection. Corneal debridement is therefore necessary, which simultaneously facilitates penetration of the antimycotic into the corneal stroma. At present, voriconazole is the medication of choice, if not changed after microbiological diagnosis to a specifically more potent substance - e.g. posaconazole or caspofungin. Amphotericin B may be used for repeated intracameral or intravitreal injection. Simultaneous application of steroids is useful.
Universitäts-Augenklinik, Leipziger Strasse 44, 39120, Magdeburg. augenklinik@ovgu.de
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Behrens-Baumann
D000935:Antifungal Agents / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000175:diagnosis* / Q000628:therapy*; D003646:Debridement / Q000379:methods*; D015821:Eye Infections, Fungal / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans
D000935:Antifungal Agents