[Effect of semax on heart rate variability in various daytime periods].
Peptide drug semax with nootropic properties did not change the heart rate variability in rats in the morning, but produced a significant optimizing action and attenuated the stress-induced sympathetic influences on the heart in the evening. It is suggested that semax has a chronotropic activity, which may participate in realization of the specific drug action.
Arushanian
E B
EB
Popov
A V
AV
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002940:Circadian Rhythm; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D018696:Neuroprotective Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone