[Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds].
It has been found that chicken hypophysectomized early in the neonatal period develop anemia, cellular and humoral immune deficiency, hypercoagulation and inhibited fibrinolysis by their 45th postnatal day. An analogous operation performed on old birds produces less significant changes in erythrocytes, immunity and hemostasis. Injections of epithalon tetrapeptide (Ala-Glu-Asp-Gly) administered to either hypophysectomized chicken or old birds during a period of 40 days completely eliminate the shifts registered in erythrocytes, immunity and hemostasis, while injections of cortagene (Ala-Glu-Asp-Pro) which is distinguished from epithalon by a different terminal aminoacid (with Gly being replaced by Pro) do not affect the parameters studied.
Kuznik
B I
BI
Pateiuk
A V
AV
Baranchugova
L M
LM
Rusaeva
N S
NS
D000375:Aging / Q000276:immunology / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D002645:Chickens; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D005342:Fibrinolysis / Q000187:drug effects / Q000502:physiology; D006487:Hemostasis / Q000187:drug effects*; D007016:Hypophysectomy; D007111:Immunity, Cellular / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D010902:Pituitary Gland / Q000502:physiology
D009842:Oligopeptides; C431545:alanyl-glutamyl-aspartylprolyine; C421253:alanyl-glutamyl-aspartyl-glycine