Metachronous Paget's disease of the breast: case report.
Paget breast disease is a kind of intraductal carcinoma that through an intracanalicular diffusion invades the basal epidermal layer, reaching the areola and nipple, producing a typical erythematous desquamative eczematous-like lesion. This neoplasia can remain undetected for a long time and inadequately treated as a dermatological affection. Synchronous or metachronous lesions are very uncommon. Surgical choice is conditioned by the presence of a tumor below the epidermal lesion, by its dimensions, and by the possible lymph node involvement. Surgical therapy can be radical or conservative. From our experience we think that lesion biopsy is always necessary to formulate a correct diagnosis and to schedule an appropriate therapeutic approach. In our case, a biopsy was performed first, then on the basis of the frozen section analysis a radical mastectomy with axillary third level lymph nodes dissection, because of the large dimensions of the lesion and the previous history of a methachronous lesion.
Gubitosi
A
A
Seconda Università degli Studi di Napoli, Azienda Ospedaliero-Universitaria, Dipartimento Assistenziale Integrato di Chirurgia Generale.
Moccia
G
G
Malinconico
F A
FA
Iside
G
G
Gilio
F
F
Cognetti
C
C
Foroni
F
F
Docimo
G
G
Ruggiero
R
R
Docimo
L
L
Agresti
M
M
D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008327:Mammography; D015409:Mastectomy, Radical; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000473:pathology / Q000601:surgery; D010144:Paget's Disease, Mammary / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed