Angiogenesis and pituitary tumors.
Pituitary adenomas often first manifest through visual symptoms. They are typically slow-growing and histologically benign tumors, but can become clinically destructive, invade adjacent structures, and recur after treatment. Unlike many other tumors that become aggressive and appear to depend upon angiogenesis in the process, pituitary adenomas tend to do so through non-angiogenic means. This article examines the role of angiogenesis in pituitary adenomas.
Department of Neuro-Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary and Brigham & Women's Hospital, 243 Charles St., Boston, MA 02114, USA. abcohen@partners.org
Adam B
AB
Cohen
Simmons
S
Lessell
D000236:Adenoma / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D000818:Animals; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001808:Blood Vessels / Q000473:pathology; D006801:Humans; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic; D010911:Pituitary Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A