IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis.
The IQGAP family comprises three proteins in humans. The best characterized is IQGAP1, which participates in protein-protein interactions and integrates diverse signaling pathways. IQGAP2 and IQGAP3 harbor all the domains identified in IQGAP1, but their biological roles are poorly defined. Proteins that bind IQGAP1 include Cdc42 and Rac1, E-cadherin, beta-catenin, calmodulin and components of the mitogen-activated protein kinase pathway, all of which are involved in cancer. Here, we summarize the biological functions of IQGAPs that may contribute to neoplasia. Additionally, we review published data which implicate IQGAPs in cancer and tumorigenesis. The cumulative evidence suggests IQGAP1 is an oncogene while IQGAP2 may be a tumor suppressor.
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Colin D
CD
White
Matthew D
MD
Brown
David B
DB
Sacks
D002448:Cell Adhesion; D002465:Cell Movement; D049109:Cell Proliferation; D005089:Exocytosis; D020690:GTPase-Activating Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016147:Genes, Tumor Suppressor; D006801:Humans; D020935:MAP Kinase Signaling System; D015394:Molecular Structure; D009362:Neoplasm Metastasis / Q000235:genetics / Q000503:physiopathology; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism*; D009857:Oncogenes; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D014158:Transcription, Genetic; D051176:beta Catenin / Q000378:metabolism; D020703:ras GTPase-Activating Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
C495270:CTNNB1 protein, human; D020690:GTPase-Activating Proteins; C101203:IQ motif containing GTPase activating protein 1; C000594387:IQGAP3 protein, human; D009363:Neoplasm Proteins; D051176:beta Catenin; D020703:ras GTPase-Activating Proteins