Cerebral sinus thrombosis in a patient with active ulcerative colitis and double heterozygosity for Factor V Leiden and prothrombin gene mutations.
Inflammatory bowel diseases are associated with increased risk for thrombotic complications, In patients with ulcerative colitis (UC) cerebral sinus venous thrombosis (CSVT) is an extremely rare complication. We report a patient with active UC and CSVT. The patient was heterozygous for Factor V Leiden and G20210A prothrombin gene mutations without other identifiable precipitating factors. This patient highlights the need for investigating the patients with UC with thrombotic complications for other thrombophilic states.
Yakaryilmaz
Fahri
F
Department of Gastroenterology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey. fahriyy67@yahoo.com
Guliter
Sefa
S
Degertekin
Bulent
B
Tuncer
Candan
C
Unal
Selahattin
S
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications* / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D009154:Mutation / Q000235:genetics*; D011241:Prednisone / Q000627:therapeutic use; D011516:Prothrombin / Q000235:genetics*; D012851:Sinus Thrombosis, Intracranial / Q000188:drug therapy / Q000209:etiology*; D055815:Young Adult
D000893:Anti-Inflammatory Agents; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D011241:Prednisone