Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus.
Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus-castus, was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro for chemiluminescence, chemotaxis, T-cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10(-8) m) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T-cell (PMBC).
Mesaik
M Ahmed
MA
International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi 75270, Pakistan.
Murad
Shahnaz
S
Khan
Khalid Mohammed
KM
Tareen
Rasool Bakhsh
RB
Ahmed
Aqeel
A
Choudhary
Muhammad Iqbal
MI
D049109:Cell Proliferation / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D005419:Flavonoids / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D016897:Respiratory Burst / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects; D020950:Vitex / Q000737:chemistry*
D005419:Flavonoids; C054133:casticin