Survival is poorer in patients with secondary core-binding factor acute myelogenous leukemia compared with de novo core-binding factor leukemia.
BACKGROUND
Therapy related secondary acute myelogenous leukemia (AML) was commonly associated with prior exposure to alkylating agents or topoisomerase inhibitor. The long-term outcome of such patients with secondary AML was found to be worse than that of patients with de novo AML. Earlier reports suggested similar outcomes for patients with de novo and secondary AML associated with core-binding factor (CBF) abnormalities.


METHODS
A total of 188 patients with CBF AML were analyzed. The frequency of secondary CBF AML was 9%.


RESULTS
Patients with secondary CBF AML were found to have significantly worse overall (OS) and event-free survival (EFS) compared with patients with de novo CBF AML. Secondary CBF AML status appeared to have only marginal significance in multivariate analysis.


CONCLUSIONS
Matched analysis (by age, Eastern Cooperative Oncology Group performance status, and additional cytogenetic abnormality) indicated worse OS and EFS in patients with secondary CBF AML.
Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. gborthak@mdanderson.org
Gautam
G
Borthakur
E
E
Lin
Nitin
N
Jain
Elihu E
EE
Estey
Jorge E
JE
Cortes
Susan
S
O'Brien
Stefan
S
Faderl
Farhad
F
Ravandi
Sherry
S
Pierce
Hagop
H
Kantarjian
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050660:Core Binding Factors / Q000378:metabolism*; D003561:Cytarabine / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000401:mortality*; D016019:Survival Analysis; D014178:Translocation, Genetic
D050660:Core Binding Factors; D003561:Cytarabine