Present risk of anthracycline or radiation-induced cardiac sequelae following therapy of malignancies in children and adolescents.
Anthracyclines are very potent drugs in the therapy of malignancies in childhood. The major dose limiting adverse effect of these drugs is the risk of dilated cardiomyopathy. We performed a retrospective study on 168 patients who were treated with anthracyclines for a malignant disease with or without chest radiation at the department of Pediatric Hematology and Oncology at the University of Duesseldorf between 2000 and 2004. During and after chemotherapy the patients were screened by echocardiography and ECG examinations prior to each administration of anthracyclines. Only four patients presented with adverse cardiac events, one of whom developed acute cardiac failure. This patient was additionally treated with chest radiation. Three of the four patients showed intermittent arrhythmias, mainly supraventricular tachycardia. One of them presented with atrial ectopic tachycardia and left ventricular dysfunction. We conclude that the frequency of cardiac sequelae after chemotherapy with anthracyclines is low under present guidelines. Detection of early cardiac sequelae may be more difficult than in the past. Only one patient with cardiac sequelae in our study group was diagnosed by regular performed examinations for cardiac sequelae of chemotherapy. We therefore need to modify our screening methods to increase the effectiveness of detection of cardiac dysfunction prior to clinical manifestation.
Department of Pediatric Cardiology and Pneumology, University Medical Center, Heinrich-Heine-University, Duesseldorf, Germany. christian@chen-design.de
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Chen
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Heusch
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Donner
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Janssen
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Göbel
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Schmidt
D000293:Adolescent; D018943:Anthracyclines / Q000627:therapeutic use / Q000633:toxicity*; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use / Q000633:toxicity*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000633:toxicity*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004452:Echocardiography / Q000187:drug effects / Q000528:radiation effects; D004562:Electrocardiography / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000528:radiation effects*; D006333:Heart Failure / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D008297:Male; D008403:Mass Screening; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D013617:Tachycardia, Supraventricular / Q000139:chemically induced / Q000175:diagnosis; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced / Q000175:diagnosis
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic