Osteoclasts pump iron.
Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in generating a positive osteoclastogenic feedback loop.
Veterans Affairs Pittsburgh Healthcare System, Department of Medicine/Hematology-Oncology, Pittsburgh, PA 15240, USA. roodmangd@upmc.edu
G David
GD
Roodman
D000818:Animals; D001862:Bone Resorption / Q000378:metabolism; D050882:CREB-Binding Protein / Q000378:metabolism; D002454:Cell Differentiation; D055785:Gene Knockdown Techniques; D007501:Iron / Q000378:metabolism*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D001678:Organelle Biogenesis; D010010:Osteoclasts / Q000378:metabolism*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D017382:Reactive Oxygen Species / Q000378:metabolism; D011990:Receptors, Transferrin / Q000378:metabolism; D015534:Trans-Activators / Q000172:deficiency* / Q000235:genetics; D014157:Transcription Factors; D014168:Transferrin / Q000378:metabolism
D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D017382:Reactive Oxygen Species; D011990:Receptors, Transferrin; C480029:Tfrc protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; D014168:Transferrin; D007501:Iron; D050882:CREB-Binding Protein; C494364:Crebbp protein, mouse