Adult neural stem cells for the treatment of neuroinflammation. Fondazione Centro San Raffaele del Monte Tabor: WO2007015173.
BACKGROUND
The application is in the field of stem cells and their therapeutic application for the treatment of inflammation.


OBJECTIVE
It aims at characterizing the potential of adult-derived neural progenitor and stem cells for the treatment of inflammation of the central nervous system (CNS).


METHODS
Neural progenitor and stem cells were isolated and expanded from the subventricular zone (SVZ) of adult mice (aNSCs). They were administered intravenously in an animal model of multiple sclerosis (MS).


RESULTS
Mice transplanted either at the disease onset or at the onset of the first relapse show clinical signs of improvements. Adult NSCs exert their therapeutical activity by reducing neuroinflammation.


CONCLUSIONS
The application claims the use of aNSCs and multipotent somatic stem cells for the treatment of inflammation, associated with neurological diseases, disorders and injuries particularly, and for inducing tolerance to the immune central and/or peripheral system.
Dublin City University, School of Biotechnology, Glasnevin, Dublin 9, Ireland. philippe.taupin@dcu.ie
Philippe
P
Taupin
D000818:Animals; D002493:Central Nervous System Diseases / Q000276:immunology / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology / Q000628:therapy*; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology / Q000628:therapy; D009474:Neurons / Q000378:metabolism; D010330:Patents as Topic; D033581:Stem Cell Transplantation / Q000379:methods*