Synthesis of some new spiropyranoquinolines and evaluation of their free radical scavenging activity.
The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide anions generated by the enzymic xanthine-xanthine oxidase system. The spiroadamatylpyranoquinolinone analogue proved to be the most efficient free radical scavenger.
Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Athens, Greece.
Vassiliki
V
Panteleon
Ioannis K
IK
Kostakis
Panagiotis
P
Marakos
Nicole
N
Pouli
Ioanna
I
Andreadou
D000409:Alanine / Q000031:analogs & derivatives / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D002934:Cinnamates / Q000737:chemistry; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005609:Free Radicals / Q000737:chemistry; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015363:Quinolones / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D001713:Biphenyl Compounds; D002934:Cinnamates; D016166:Free Radical Scavengers; D005609:Free Radicals; D010851:Picrates; D011714:Pyrans; D011804:Quinolines; D015363:Quinolones; D013141:Spiro Compounds; C420451:TA 270; C004931:1,1-diphenyl-2-picrylhydrazyl; C052785:rebamipide; D000409:Alanine