Autoimmune thyroid disease in children and adolescents with type 1 diabetes mellitus in Northwest Iran.
OBJECTIVE
To investigate the prevalence of autoimmune thyroid disease in diabetic children in Northwest Iran.


METHODS
In a cross-sectional study from February 2006 to November 2007, serum levels of anti-thyroid peroxidase, and anti-thyroglobulin antibodies, and thyrotropin hormone were measured with ELISA method in 176 diabetic children (78 Male and 98 Female) at a mean age of 8.3 +/- 3.7 and mean diabetes duration of 1.6 +/- 2.5 years, who were referred to the Pediatric-Endocrinology Clinic of Tabriz University of Medical Sciences, Tabriz, Iran.


RESULTS
Autoimmune thyroid disease was found in 12% of patients (8.6% female, and 3.4% male). Significant levels were found for anti-thyroid peroxidase (10.2%), anti-thyroglobulin (8%), and both antibodies (6.3%) in all patients.


CONCLUSIONS
We concluded that autoimmune thyroid disease in Iranian children, and adolescents with type 1 diabetes has a medium prevalence rate compared with those of other countries. The disease is more common in female, and older diabetic patients.
Department of Pediatrics, Tabriz University of Medical Sciences, Tabriz, Iran.
Siamak
S
Shiva
Afshin G
AG
Behbahan
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D007492:Iran; D008297:Male; D013967:Thyroiditis, Autoimmune / Q000150:complications*