Angioimmunoblastic T-cell lymphoma with autoimmune thrombocytopenia: a report of two cases.
We report two patients, a 68-year-old man (Case 1) and a 66-year-old man (Case 2), with polyclonal gammopathy, lymphadenopathy, thrombocytopenia, and high platelet-associated IgG (PAIgG) level. We initially diagnosed them as having angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). From confirmation of clear cells by careful observation and detection of rearrangement bands of T cell receptors by Southern blot hybridization analysis, we finally concluded that their diagnoses were compatible with angioimmunoblastic T-cell lymphoma (AILT). AILT with autoimmune thrombocytopenia (AIT) is very rare, and all the reported cases were Japanese ones.
Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki 311-4198, Japan. oka-k@gb3.so-net.ne.jp
Kuniyuki
K
Oka
Reizo
R
Nagayama
Yasushi
Y
Yatabe
Shigeruko
S
Iijima
Naoyoshi
N
Mori
D000368:Aged; D015139:Blotting, Southern; D003937:Diagnosis, Differential; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000473:pathology*; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000150:complications / Q000473:pathology*; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000473:pathology*