[Stem cells and precancer inflammatory conditions in development of age-specific cancer].
Most, if not all epithelial tissues contain stem/progenitor cells and niche, where the cells are kept on deposit. These cells are responsible for normal tissue renewal or the regeneration following damage. The age-increased incidence of epithelial cancer (above 90% among other tumors) has been associated with age-reduced stability to injury in epithelium and its decline in regeneration capacity. What makes the epithelial tissues susceptible to cancer transformation under aging? The goal of this review is to check the hypothesis that injury-induced changes in aging epithelium create opportunities for chronic (not acute) inflammatory response, which support pro-cancer microenvironment conditions similar to cancer microenvironment. Both this microenvironments is able to stimulate the homing and division of stem/progenitor cells but not their differentiation. These local changes together with age-reduced immunity, could contribute to the pathogenesis of age-specific cancer.
Shvartsburd
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PM
D000375:Aging / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000473:pathology; D002633:Chemotaxis / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000473:pathology / Q000502:physiology; D011230:Precancerous Conditions / Q000276:immunology / Q000473:pathology*; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology