Neurotransmitter systems in alcohol dependence.
An interplay of different neurotransmitter systems has been implicated in the development and maintenance of alcohol dependence. Here we focus on neuroadaptations in reward-related neurotransmitter systems and their impact on central processing of alcohol-associated and reward-indicating stimuli. We discuss genotype effects on cue-induced neuronal activation and present new computational methods based on machine learning to deal with complex genotype-phenotype interactions, e.g. between brain atrophy and genes associated with glutamatergic and dopaminergic neurotransmission.
Heinz
A
A
Department of Psychiatry and Psychotherapy, CCM, Charité University Medicine, Berlin, Germany. andreas.heinz@charite.de
Beck
A
A
Wrase
J
J
Mohr
J
J
Obermayer
K
K
Gallinat
J
J
Puls
I
I
D000437:Alcoholism / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D001284:Atrophy / Q000139:chemically induced / Q000235:genetics; D000431:Ethanol / Q000009:adverse effects / Q000494:pharmacology; D055106:Genome-Wide Association Study / Q000379:methods; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D018377:Neurotransmitter Agents / Q000235:genetics / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology*
D018377:Neurotransmitter Agents; D000431:Ethanol