The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea.
The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following activities: antitumoral, trypanocidal and leishmanicidal. Dicentrinone showed weak cytotoxicity, but it had the strongest leishmanicidal activity (IC(50) 0.01 microM). Duguetine and duguetine beta-N-oxide caused considerable antitumoral activity in every cell lines evaluated, although duguetine was more active against trypomastigote forms (IC(50) 9.32 microM) than other alkaloids tested.
da Silva
D B
DB
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, SP, Brazil. debrentan@fcfrp.usp.br
Tulli
E C O
EC
Militão
G C G
GC
Costa-Lotufo
L V
LV
Pessoa
C
C
de Moraes
M O
MO
Albuquerque
S
S
de Siqueira
J M
JM
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D001060:Aporphines / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D007892:Leishmania braziliensis / Q000187:drug effects*; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000302:isolation & purification*; D014349:Trypanosoma cruzi / Q000187:drug effects
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D010936:Plant Extracts; D014344:Trypanocidal Agents; C546631:duguetine; C546632:duguetine beta-N-oxide; C406631:dicentrinone