The C825T polymorphism in the G-protein beta 3 subunit gene in Chinese patients with preeclampsia.
OBJECTIVE
The objective of the study was to investigate the relationship of a C825T polymorphism of the gene encoding the G protein beta3 subunit with preeclampsia in a South-West Chinese population.


RESULTS
In the case-control study which included 221 preeclamptic case subjects and 277 normal control subjects the allele frequency of 825CT in the GNB3 gene was 47.29% in patients with preeclampsia and 49.28% in the control group. Furthermore, there was no significant association between the polymorphism and blood pressure levels in the case or control group. However, it showed that the TT homozygotes (n = 39) in obese patients had higher diastolic blood pressure levels than CC homozygotes (n = 47) or CT heterozygotes (n = 84) during pregnancy (p < 0.05).


CONCLUSIONS
Our work does not provide evidence in favor of GNB3 C825T being a candidate gene for conferring genetic susceptibility to preeclampsia in a South West Chinese population.
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, PR China.
Guolin
G
He
Xinghui
X
Liu
Ping
P
Fan
Rui
R
Liu
Yi
Y
Huang
Xiaosu
X
Wang
Qin
Q
Li
Hongmei
H
Wu
Yu
Y
Liu
Bingwen
B
Liu
Huai
H
Bai
D000328:Adult; D044466:Asian People; D001794:Blood Pressure / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D055815:Young Adult
C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins