Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil).
Over 1,100 cases of hantavirus pulmonary syndrome (HPS) have occurred in Brazil since 1993, but little is known about Brazilian hantaviruses, and many of their rodent hosts remain unknown. The Araucaria hantavirus (ARAUV) was described recently from HPS patients from Paraná, in southern Brazil, but its host could not be identified. In this study, rodents were captured from regions with high HPS prevalence to address this issue. ARAUV RNA was detected in three distantly related rodent species: Oligoryzomys nigripes, Oxymycterus judex and Akodon montensis. Furthermore, a specimen of A. montensis was infected with a Jaborá-like virus, implying that A. montensis can be infected by at least two different hantaviruses. The presence of the same hantavirus strain in three different rodent species and the co-circulation of two different strains in the same rodent species highlight the potential for genomic reassortment, which could have an impact on hantavirus transmission dynamics in nature and on human epidemiology.
Raboni
Sonia Mara
SM
Instituto Carlos Chagas, ICC/Fiocruz/PR, Brazil.
Hoffmann
Federico G
FG
Oliveira
Renata C
RC
Teixeira
Bernardo R
BR
Bonvicino
Cibele R
CR
Stella
Vanessa
V
Carstensen
Suzana
S
Bordignon
Juliano
J
D'Andrea
Paulo S
PS
Lemos
Elba R S
ER
Duarte Dos Santos
Claudia Nunes
CN
D000818:Animals; D001938:Brazil / Q000453:epidemiology; D004197:Disease Reservoirs / Q000821:virology*; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D018804:Hantavirus Pulmonary Syndrome / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012377:Rodentia / Q000821:virology*