ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans.
OBJECTIVE
To test the association between ARTS1 polymorphisms and Koreans with ankylosing spondylitis (AS).


METHODS
All patients and controls were Korean. 872 patients with AS fulfilling the modified New York criteria and 403 healthy controls were genotyped for five single nucleotide polymorphisms (SNPs), rs27044, rs17482078, rs10050860, rs30107 and rs2287987, known to be associated with AS in Caucasians.


RESULTS
SNPs rs27044 (p=9.37 x 10(-7)) and rs30187 (p=7.16 x 10(-6)) of ARTS1 were significantly associated with AS in Koreans. There was no significant association for rs17482078, rs10050860 and rs2287987. Two four-marker haplotypes were found to be associated with AS (GCCT: p=4.71 x 10(-7), CCCC: p=8.56 x 10(-6)).


CONCLUSIONS
This is first confirmation in a non-Caucasian population that genetic polymorphisms in ARTS1 are associated with AS, implicating common pathogenetic mechanisms in Korean and Caucasian patients with AS.
The Hospital for Rheumatic Diseases, Hanyang University, Seoul 133-792, Republic of Korea.
Chan-Bum
CB
Choi
Tae-Hwan
TH
Kim
Jae-Bum
JB
Jun
Hye-Soon
HS
Lee
Seung Cheol
SC
Shim
Bitnara
B
Lee
Angela
A
Pope
Mohammed
M
Uddin
Proton
P
Rahman
Robert D
RD
Inman
D000328:Adult; D000626:Aminopeptidases / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens; D020641:Polymorphism, Single Nucleotide; D013167:Spondylitis, Ankylosing / Q000235:genetics*
D015778:Minor Histocompatibility Antigens; D000626:Aminopeptidases; C464841:ERAP1 protein, human