Weight and plasma lipid control by decaffeinated green tea.
We investigated whether regular decaffeinated green tea intake could modulate body weight in an experimental model of obesity. Male leptin-deficient (ob/ob) mice and their C57BL/6J lean littermates (4 weeks of age; n 20/genotype) were assigned randomly to receive either decaffeinated green tea or vehicle, for 6 weeks. Body weights were recorded weekly and fluid intake was measured at each replacement. Blood was collected from the heart into collection tubes, with Li(+)-heparin as the anticoagulant. Administration of decaffeinated green tea to ob/ob mice significantly slowed their rate of weight gain, as compared with animals that were fed buffer alone. This effect is apparent after only 1 week of supplementation. No significant difference was recorded between C57BL/6J lean mice administrated decaffeinated green tea and those given buffer alone. Decaffeinated green tea consumption by ob/ob mice was also associated with significantly lower cholesterolemia, triglyceridemia, and adiponectin concentration. Fecal lipids did not change significantly throughout the experiment. In conclusion, administration of decaffeinated green tea might contribute to weight control and provides an opportunity for through-the-day consumption, without the excitatory effects of caffeine.
Laboratory of "Micronutrients and Cardiovascular Disease", UR4, UPMC Univ 06, Paris, France. doriane.richard@upmc.fr
Doriane
D
Richard
Kaouthar
K
Kefi
Ullah
U
Barbe
Andrea
A
Poli
Pedro
P
Bausero
Francesco
F
Visioli
D052242:Adiponectin / Q000097:blood; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002110:Caffeine; D002392:Catechin / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005243:Feces / Q000737:chemistry; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D020738:Leptin / Q000235:genetics; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013662:Tea / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects*
D052242:Adiponectin; D019440:Anti-Obesity Agents; D000960:Hypolipidemic Agents; D020738:Leptin; D008055:Lipids; D028321:Plant Preparations; D013662:Tea; D014280:Triglycerides; D002110:Caffeine; D002392:Catechin; D002784:Cholesterol