Kounis Syndrome secondary to cefuroxime axetil use in an asthmatic patient.
A sixty-one year old female with a past history of asthma was admitted to the emergency department because of vertigo, nausea, vomiting, chest pain and generalized erythema after taking an oral dose of cefuroxime axetil. Electrocardiography showed ST segment elevation in inferior leads. After coronary angiography, type 2 variant of Kounis Syndrome is diagnosed. We present first drug induced Kounis Syndrome in an asthmatic patient with severe anaphylactic shock. The present report also shows that atopic people expressing an amplified mast cell degranulation may have more serious hemodynamic decompensation during hypersensitivity reactions.
Ilhan
Erkan
E
Güvenç
Tolga Sinan
TS
Poyraz
Esra
E
Ayhan
Erkan
E
Soylu
Ozer
O
D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D000707:Anaphylaxis / Q000139:chemically induced* / Q000503:physiopathology; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001249:Asthma / Q000150:complications* / Q000503:physiopathology; D002444:Cefuroxime / Q000009:adverse effects / Q000031:analogs & derivatives*; D017023:Coronary Angiography; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D002444:Cefuroxime; C040738:cefuroxime axetil