Gene therapy in transplantation.
Gene therapy is an exciting and novel technology that offers the prospect of improving transplant outcomes beyond those achievable with current clinical protocols. This review explores both the candidate genes and ways in which they have been deployed to overcome both immune and non-immune barriers to transplantation success in experimental models. Finally, the major obstacles to implementing gene therapy in the clinic are considered.
Laurence
Jerome M
JM
Collaborative Transplantation Research Group, Bosch Insitute, Royal Prince Alfred Hospital and University of Sydney, NSW 2006, Australia.
Allen
Richard D M
RD
McCaughan
Geoffrey W
GW
Logan
Grant J
GJ
Alexander
Ian E
IE
Bishop
G Alex
GA
Sharland
Alexandra F
AF
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D016207:Cytokines / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006084:Graft Rejection / Q000235:genetics / Q000517:prevention & control; D006801:Humans; D023001:Transplantation Tolerance / Q000235:genetics*
D016207:Cytokines