Advances in Aurora kinase inhibitor patents.
BACKGROUND
Aurora-A, Aurora-B and Aurora-C, members of serine/threonine kinase family, play an important role in mitosis. They are essential for spindle assembly, centrosome maturation, chromosomal segregation and cytokinesis during mitosis. Abnormalities in the mitotic process as a result of overexpression/amplification of Aurora kinase have been linked to genomic instability leading to tumorigenesis. Hence, the use of Aurora kinase small-molecule inhibitors as a potential molecular-targeted therapeutic intervention for cancer is being pursued.


OBJECTIVE
A number of reviews focus on the biology of Aurora kinase; a few focus on the medicinal chemistry aspect of Aurora kinase inhibitor development. Here, we review the medicinal chemistry aspect of Aurora kinase inhibitors, with a particular emphasis on the patent literature.


METHODS
The Scifinder and Delphion databases were used to search the literature for Aurora kinase inhibitors. Approximately 150 patents and 700 journal references are available, most of them published in the last 5 years. CONCLUSION/RESULTS: Analysis of the literature reveals three common strategies utilized by different groups in developing Aurora kinase inhibitors. These are discussed in detail and could be of use to medicinal chemists in laying out new strategies for developing novel Aurora kinase inhibitors.
Coumar
Mohane Selvaraj
MS
Division of Biotechnology & Pharmaceutical Research, Zhunan Town, Miaoli County 350, Taiwan, ROC.
Cheung
Chun Hei Antonio
CH
Chang
Jang-Yang
JY
Hsieh
Hsing-Pang
HP
D000818:Animals; D064107:Aurora Kinase B; D064108:Aurora Kinase C; D064127:Aurora Kinases; D016503:Drug Delivery Systems; D015195:Drug Design; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008938:Mitosis / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D010330:Patents as Topic; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D047428:Protein Kinase Inhibitors; C576921:AURKB protein, human; C576927:AURKC protein, human; D064107:Aurora Kinase B; D064108:Aurora Kinase C; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases