Inequalities in breast cancer stage at diagnosis in the Trent region, and implications for the NHS Breast Screening Programme.
BACKGROUND
This study investigates risk factors for diagnosis with late-stage breast cancer in order to identify inequalities and inform the understanding of barriers affecting access to mammography screening.


METHODS
Data from the Trent Cancer Registry were used to identify all women with invasive breast cancer, diagnosed in 1998-2006. Risk of diagnosis with late-stage breast cancer was calculated to quantify strength of association between exposure and outcome.


RESULTS
Women outside the age group for routine screening were approximately 30% [<50 years, relative risk (RR) = 1.34 (95% confidence interval, CI: 1.26-1.43) and >70 years, RR = 1.27 (95% CI: 1.19-1.36)] more likely to be diagnosed with late-stage breast cancer; the most deprived women were 37% [RR = 1.37 (95% CI: 1.01-2.56)] more likely to be diagnosed with Stage IV breast cancer; ethnic minority women were 15% [RR = 1.15 (95% CI: 1.09-1.22)] more likely to be diagnosed with late-stage breast cancer and women resident in 5 of 11 Trent Primary Care Trusts (PCT) had a greater than 30% increased risk of diagnosis with late-stage breast cancer than those in Nottingham City PCT.


CONCLUSIONS
These findings highlight the need for appropriate targeted interventions to address compositional and contextual inequalities that are evident in breast cancer stage at diagnosis.
Cuthbertson
Sarah A
SA
Trent Cancer Registry, Sheffield S10 3TG, UK. sarah.cuthbertson@nhs.net
Goyder
Elizabeth C
EC
Poole
Jason
J
D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000208:ethnology; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer; D004739:England / Q000453:epidemiology; D005260:Female; D054624:Health Status Disparities; D006801:Humans; D008327:Mammography; D008403:Mass Screening; D008875:Middle Aged; D009313:National Health Programs; D009361:Neoplasm Invasiveness / Q000175:diagnosis*; D009367:Neoplasm Staging / Q000706:statistics & numerical data*; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D012042:Registries; D012307:Risk Factors; D012959:Socioeconomic Factors