Life on the edge: telomeres and persistent DNA breaks converge at the nuclear periphery.
Persistent DNA double-strand breaks and telomeres represent genomic hazards, as they can instigate inappropriate repair reactions. Two recent papers by Oza and colleagues (pp. 912-917) and Schober and colleagues (pp. 928-938) show that both types of DNA ends are sequestered from bulk DNA by Mps3, a SUN domain protein that spans the inner nuclear membrane. Anchorage maintains telomere integrity and steers double-strand breaks toward specialized repair pathways. This work defines the nuclear periphery as a subcompartment where dangerous DNA elements can be handled with care.
Gartenberg
Marc R
MR
Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA. gartenbe@umdnj.edu
D002467:Cell Nucleus / Q000502:physiology*; D043171:Chromosomal Instability; D053903:DNA Breaks, Double-Stranded; D004261:DNA Replication; D008565:Membrane Proteins / Q000378:metabolism; D009685:Nuclear Envelope / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*; D016615:Telomere / Q000235:genetics / Q000378:metabolism*
D008565:Membrane Proteins