[Age-dependant alterations of energy metabolism in rodents from radiation contaminated areas].
The activity of succinate dehydrogenase, pyruvate dehydrogenase and lactate dehydrogenase in homogenates from cardiac muscle, liver and brain of wild rodents inhabiting areas with high level of radioactivity (Komi Republic, Chernobyl NPP accident 30-km zone). There is a deficiency in pyruvate and succinate oxidation as well as the high rate of the lactate oxidation processes in organs of senescent wild rodents from radioactive polluted sites. The high level of lactate dehydrogenase activity in cardiac muscle and liver has been demonstrated in both young and senescent animals that is the aging process development evidence.
Kudiasheva
A G
AG
D000375:Aging / Q000378:metabolism / Q000528:radiation effects*; D000818:Animals; D001921:Brain / Q000201:enzymology; D004734:Energy Metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D009928:Organ Specificity; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D011848:Radioactive Pollutants / Q000009:adverse effects*; D012377:Rodentia; D013385:Succinate Dehydrogenase / Q000378:metabolism
D011768:Pyruvate Dehydrogenase Complex; D011848:Radioactive Pollutants; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase