Colloid-induced kidney injury: experimental evidence may help to understand mechanisms.
Fluid resuscitation is widely used, and many patients are therefore exposed to plasma volume expanders. Among these, colloids, particularly hydroxyethyl starches, have been shown in recent experiments and clinical studies to induce acute kidney injury. The mechanisms of colloid-induced acute kidney injury remain incompletely elucidated. The risks associated with colloid osmotic pressure elevation in vivo and the high incidence of osmotic nephrosis lesions in experimental models and clinical studies indicate that hydroxyethyl starches can no longer be considered safe.
Schortgen
Frédérique
F
AP-HP, Groupe Hospitalier Albert Chenevier - Henri Mondor, Réanimation Médicale, F-94000 Créteil, France. frederique.schortgen@hmn.aphp.fr
Brochard
Laurent
L
D058186:Acute Kidney Injury / Q000139:chemically induced*; D003102:Colloids / Q000009:adverse effects* / Q000627:therapeutic use; D000075202:Contraindications; D019317:Evidence-Based Medicine; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D009997:Osmotic Pressure / Q000502:physiology
D003102:Colloids