Risk factors in development of motor complications in Chinese patients with idiopathic Parkinson's disease.
Motor complications induced by levodopa (L-dopa) treatment in Parkinson's disease (PD) are not well documented in patients of Chinese ethnicity. We performed a cross-sectional study to investigate the prevalence of dyskinesias and motor fluctuations, and the factors determining their development, in a population of Chinese patients with PD. Among 137 patients with PD, 98 (71.5%) had received a L-dopa preparation. Motor fluctuations were found in 74.5% and dyskinesias in 77.6% of the 98 patients. Patients with dyskinesias were younger at onset of disease than those without. Patients with dyskinesias and motor fluctuations had significantly longer duration of PD and L-dopa treatment, higher daily doses of L-dopa, and higher scores in the 39-item Parkinson's Disease Questionnaire (PDQ-39), when compared to patients without motor complications. Among these factors, motor fluctuations were best predicted by duration of L-dopa treatment and dyskinesias by disease duration. We conclude that motor complications are closely related to disease and treatment parameters, especially the treatment and disease duration.
Hong Kong Baptist University, Kowloon Tong, Hong Kong.
Wan Fung
WF
Kum
Jing
J
Gao
Siva Sundara Kumar
SS
Durairajan
Sui Cheung
SC
Man
Li Xia
LX
Xie
Jia Hong
JH
Lu
Wai Leuk
WL
Fong
Min
M
Li
D000328:Adult; D000367:Age Factors; D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002681:China; D003430:Cross-Sectional Studies; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy*; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
D000978:Antiparkinson Agents; D007980:Levodopa