The effectiveness of FloSeal matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study.
BACKGROUND
The objective of this study was to compare the effectiveness of FloSeal matrix hemostatic agent with hemostatic surgical procedures and Tabotamp in thyroid surgery.


METHODS
One hundred fifty-five consecutive total thyroidectomy patients were recruited at our institution between January 2005 and December 2007. Exclusion criteria were applied. Patients were randomized to one of three hemostatic approaches: 49 received surgical procedures only, and 52 received oxidized regenerated cellulose patch (Tabotamp Fibrillar 2.5 x 5 cm) and 54 FloSeal (5,000 U/5 mL). The same surgeon performed all operations.


RESULTS
Mean operating time was reduced in the FloSeal group (105 min) vs. surgical (133 min, p = 0.02) and vs. Tabotamp (122 min, p = 0.0003). Also, wound drain removal occurred earlier with FloSeal (p = 0.006 vs. surgical; p = 0.008 vs. Tabotamp) resulting in shorter postoperative hospital stay in the FloSeal group (p = 0.02 vs. surgical; p = 0.002 vs. Tabotamp).


CONCLUSIONS
FloSeal matrix is an effective additional agent to conventional haemostatic procedures in thyroid surgery.
Section of General and Thoracic Surgery, Department of Applications in Surgery of Innovative Technologies, University Medical School of Bari, Policlinico, Piazza G. Cesare 11, 70124, Bari, Italy. mario.testini@chirgen2.uniba.it
Mario
M
Testini
Rinaldo
R
Marzaioli
Germana
G
Lissidini
Agostino
A
Lippolis
Francesco
F
Logoluso
Angela
A
Gurrado
Domenica
D
Lardo
Elisabetta
E
Poli
Giuseppe
G
Piccinni
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use*; D006488:Hemostasis, Surgical; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013965:Thyroidectomy / Q000009:adverse effects; D055815:Young Adult
C411004:FloSeal Matrix; D006490:Hemostatics