Tenascins and their implications in diseases and tissue mechanics.
Tenascins are glycoproteins found in the extracellular matrix (ECM) of many tissues. Their role is not only to support the tissue structurally but also to regulate the fate of the different cell types populating the ECM. For instance, tenascins are required when active tissue modeling during embryogenesis or re-modeling after injury occurs. Interestingly, the four members of the tenascin family, tenascin-C, -X, -R and -W, show different and often mutually exclusive expression patterns. As a consequence, these structurally related proteins display distinct functions and are associated with distinct pathologies. The present review aims at presenting the four members of the tenascin family with respect to their structure, expression patterns and implications in diseases and tissue mechanics.
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland.
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Brellier
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Tucker
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Chiquet-Ehrismann
D001249:Asthma / Q000378:metabolism; D001696:Biomechanical Phenomena; D003238:Connective Tissue / Q000378:metabolism*; D004535:Ehlers-Danlos Syndrome / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D019063:Tenascin / Q000378:metabolism*
D019063:Tenascin