Influence of Helicteres isora administration for diabetes mellitus: the effect on changes in tissue fatty acid composition.
The aim of the present study was to evaluate the effect of aqueous bark extract of Helicteres isora (HI) (Sterculiaceae) on the blood glucose, plasma insulin and fatty acid composition of the total lipids in the liver, kidney and brain of control and streptozotocin (STZ) diabetic rats. The analysis of fatty acids showed that there was a significant increase in the concentrations of palmitic acid (16:1), stearic acid (18:0) and oleic acid (18:1) in the liver, kidney and brain, whereas the concentrations of linolenic acid (18:3) and arachidonic acid (20:4) were significantly decreased in STZ diabetic rats. Oral administration of the aqueous bark extract of HI (100, 200mg/kg body weight) for 30 days to diabetic rats decreased the concentrations of fatty acids, viz., palmitic, stearic, and oleic acid, whereas linolenic and arachidonic acid were elevated. These results suggest that HI exhibits antidiabetic and antihyperlipidemic effects in STZ induced diabetic rats. It also prevents the fatty acid changes produced during diabetes. The antidiabetic and antihyperlipidemic effects of HI are more potent than those of tolbutamide, as standard drug. The results of the present study indicate that HI showed an antihyperlipidemic effect in addition to its antidiabetic effect in type 2 diabetic rats.
Manonmaniam Sundaranar University, Sri Paramakalyani Centre for Environmental Sciences, Alwarkurichi, Tamilnadu 627 412, India. pgsvedhakumar@yahoo.com
G
G
Kumar
Sharmila
S
Banu
A G
AG
Murugesan
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005227:Fatty Acids / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008297:Male; D019660:Malvaceae / Q000737:chemistry*; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D005227:Fatty Acids; D007328:Insulin; D010936:Plant Extracts