Inducible cAMP early repressor (ICER) and brain functions.
The inducible cAMP early repressor (ICER) is an endogenous repressor of cAMP-responsive element (CRE)-mediated gene transcription and belongs to the CRE-binding protein (CREB)/CRE modulator (CREM)/activating transcription factor 1 (ATF-1) gene family. ICER plays an important role in regulating the neuroendocrine system and the circadian rhythm. Other aspects of ICER function have recently attracted heightened attention. Being a natural inducible CREB antagonist, and more broadly, an inducible repressor of CRE-mediated gene transcription, ICER regulates long-lasting plastic changes that occur in the brain in response to incoming stimulation. This review will bring together data on ICER and its functions in the brain, with a special emphasis on recent findings highlighting the involvement of ICER in the regulation of long-term plasticity underlying learning and memory.
Unit for Molecular Neurobiology of Learning and Memory, Okinawa Institute of Science and Technology, Uruma, Okinawa 904-2234, Japan.
Gilyana
G
Borlikova
Shogo
S
Endo
D000818:Animals; D001921:Brain / Q000502:physiology*; D051786:Cyclic AMP Response Element Modulator / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D009473:Neuronal Plasticity
D017362:Cyclic AMP Response Element-Binding Protein; D051786:Cyclic AMP Response Element Modulator