Injection of day 2 embryo culture supernatant into the uterine cavity did not improve the pregnancy rate of day 3 embryo transfer in patients who underwent in vitro fertilization-embryo transfer: a randomized clinical trial.
OBJECTIVE
To evaluate the effectiveness of uterine cavity injection of day 2 embryo culture supernatant before day 3 embryo transfer in patients who are undergoing in vitro fertilization-embryo transfer.


METHODS
Randomized controlled trial.


METHODS
A reproductive medical centre.


METHODS
A total of 90 infertile women, 45 of them in the study group and 45 in the control group.


METHODS
Uterine cavity infection of day 2 embryo culture supernatant before day 3 embryo transfer.


METHODS
Embryo implantation rate and pregnancy rate.


RESULTS
The pregnancy versus implantation rates in the study group and control group were 48.9% versus 44.4% and 27.3% versus 22.1%, respectively. Although both pregnancy and implantation rates in the study group were higher than those in the control group, no statistically significant differences were found in these two parameters.


CONCLUSIONS
Injection of day 2 embryo culture supernatant into the uterine cavity cannot improve the implantation and pregnancy rates of day 3 embryo transfer.
Zhu
Wenjie
W
Department of Reproductive Medical Centre, ShenZhen Maternity and Child Healthcare Hospital, Shen Zhen, 518048, Guangdong, People's Republic of China. zhuwenjie542004@yahoo.com.cn
Li
Xuemei
X
Fu
Zhihong
Z
Tang
Zhen
Z
Chen
Xiumin
X
Zhou
Yonghong
Y
Geng
Qian
Q
D000328:Adult; D000465:Algorithms; D017077:Culture Media, Conditioned / Q000494:pharmacology*; D046149:Embryo Culture Techniques; D010064:Embryo Implantation / Q000187:drug effects / Q000502:physiology; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D007267:Injections; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D013997:Time Factors; D014599:Uterus / Q000187:drug effects*; D055815:Young Adult
D017077:Culture Media, Conditioned