Epidemiologic investigation of a 2007 outbreak of Serratia marcescens bloodstream infection in Texas caused by contamination of syringes prefilled with heparin and saline.
This retrospective cohort study found that syringes prefilled with heparin flush solution caused an outbreak of Serratia marcescens bloodstream infection at an outpatient treatment center in Texas in 2007. The epidemiologic study supported this conclusion, despite the lack of microbiologic evidence of contamination from environmental and product testing. This report underscores the crucial contributions that epidemiologic studies can make to investigations of outbreaks that are possibly product related.
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. john.su@cdc.hhs.gov
John R
JR
Su
David B
DB
Blossom
Wendy
W
Chung
Jessica Smartt
JS
Gullion
Neil
N
Pascoe
Gary
G
Heseltine
Arjun
A
Srinivasan
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D004340:Drug Contamination; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D016868:Serratia Infections / Q000453:epidemiology* / Q000382:microbiology; D012706:Serratia marcescens; D012965:Sodium Chloride / Q000008:administration & dosage; D013594:Syringes / Q000382:microbiology*; D013781:Texas / Q000453:epidemiology; D055815:Young Adult
D012965:Sodium Chloride; D006493:Heparin