The rs1447295 at 8q24 is a risk variant for prostate cancer in Taiwanese men.
OBJECTIVE
To determine the association of a common variant, rs1447295, at the 8q24 region with prostate cancer (PCa) risk in Taiwanese men. Common variants at the 8q24 region have been shown to be associated with PCa risk. The variant rs1447295 has shown the strongest association. Most of the studies have been performed in European and American populations.


METHODS
This case-control study comprised 340 PCa patients and 337 controls. Genotyping was performed for rs14417295 to test for the association between its risk allele and PCa. Its association with disease stage, Gleason score, PSA level, and disease aggressiveness was also determined.


RESULTS
The A allele of rs1447295 was significantly associated with increased PCa risk (odds ratio = 1.49, 95% CI = 1.12-1.99). When compared with controls, the risk allele A was more frequent in PCa patients of both stages I+II (P = .028) and stages III+IV (P = .023), in patients of all Gleason scores (P < .05 in all subgroups), in patients with PSA levels >20 ng/mL (P = .001), and in patients with aggressive disease (P = .005).


CONCLUSIONS
This study confirmed that the A allele of rs1447295 is associated with a high risk of PCa in Taiwanese men.
Division of Preventive Medicine, Institute of Public Health, School of Medicine, National Yang Ming University, Taipei, Taiwan.
Marcelo
M
Chen
Yu-Chuen
YC
Huang
I-Ling
IL
Ko
Stone
S
Yang
Yen-Hwa
YH
Chang
William Ji-Shian
WJ
Huang
Yi-Ming Arthur
YM
Chen
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D013624:Taiwan