Pharyngeal muscle contraction modifies peri-pharyngeal tissue pressure in rabbits.
We examined the influence of pharyngeal dilator muscle activity on upper airway extraluminal tissue pressure (ETP) distribution and upper airway patency. We studied seven anaesthetised, supine, spontaneously breathing NZ white rabbits. ETP was measured via pressure transducer tipped catheters in lateral (ETP(lat)) and anterior (ETP(ant)) pharyngeal wall tissues. Airflow (V) and tracheal pressure (P) were monitored and upper airway resistance (RUA) calculated. Genioglossus (GG) or bilateral sternohyoid (SH) muscles were electrically stimulated. Tongue protrusion (TP) during GG stimulation was measured. With GG stimulation, RUA decreased to 57.8+/-10.9% (mean+/-S.E.M.) of baseline and TP increased to 4.8+/-0.5mm (both p<0.05), but ETP(lat) (2.6+/-1.5 cm H(2)O) and ETP(ant) (1.4+/-0.8 cm H(2)O) were unchanged. SH stimulation reduced RUA to 53.6+/-6.8%, and ETP(lat) fell by 1.0+/-0.4 cm H(2)O (both p<0.05). ETP(ant) was unchanged. GG muscle contraction decreased RUA without altering ETP, whereas SH contraction altered RUA and ETP(lat), but not ETP(ant). Contraction of the upper airway dilator muscles results in improvements in upper airway patency associated with changes in peri-pharyngeal tissue pressure.
Ludwig Engel Centre for Respiratory Research, Westmead Millennium Institute, Australia. kristina_kairaitis@wmi.usyd.edu.au
Kristina
K
Kairaitis
Manisha
M
Verma
Victoria
V
Fish
John R
JR
Wheatley
Terence C
TC
Amis
D000403:Airway Resistance / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001703:Biophysics; D004558:Electric Stimulation / Q000379:methods; D008170:Lung Compliance; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D010609:Pharyngeal Muscles / Q000502:physiology*; D010614:Pharynx / Q000502:physiology*; D011312:Pressure; D011817:Rabbits; D012119:Respiration; D016683:Supine Position; D013990:Tidal Volume