Guest binding drives reversible atropisomerism in cavitand hosts.
Guest-love-ometer: The equilibrium inside-outside atropisomeric ratio of ortho-substituted phenyl cavitands shows a strong solvent dependence. The competition between the ortho-substituent and the solvent guest for the bowl cavity leads to a sensitive system for the measurement of relative guest binding affinities.
Nguyen
Thanh V
TV
Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.
Sinclair
David J
DJ
Willis
Anthony C
AC
Sherburn
Michael S
MS