Airway hyperresponsiveness with chest strapping: A matter of heterogeneity or reduced lung volume?
Chest wall strapping has been recently shown to be associated with an increase in airway responsiveness to methacholine. To investigate whether this is the result of the decreased lung volume or an increased heterogeneity due to chest wall distortion, ten healthy volunteers underwent a methacholine challenge at control conditions and after selective strapping of the rib cage, the abdomen or the whole chest wall resulting in similar decrements of functional residual capacity and total lung capacity but causing different distribution of the bronchoconstrictor. Methacholine during strapping reduced forced expiratory flow, dynamic compliance, and reactance at 5Hz and increased pulmonary resistance and respiratory resistance at 5Hz that were significantly greater than at control and associated with a blunted bronchodilator effect of the deep breath. However, no significant differences were observed between selective and total chest wall strapping, suggesting that the major mechanism for increasing airway responsiveness with chest wall strapping is the breathing at low lung volume rather than regional heterogeneities.
Pellegrino
Riccardo
R
Centro di Fisiopatologia Respiratoria e di Studio della Dispnea, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy.
Pompilio
Pasquale P
PP
Bruni
Giulia Innocenti
GI
Scano
Giorgio
G
Crimi
Claudia
C
Biasco
Luigi
L
Coletta
Giuseppe
G
Cornara
Giuseppe
G
Torchio
Roberto
R
Brusasco
Vito
V
Dellacà
Raffaele L
RL
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology*; D000704:Analysis of Variance; D006801:Humans; D007103:Immobilization; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance / Q000187:drug effects; D008176:Lung Volume Measurements / Q000379:methods; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D008875:Middle Aged; D010277:Parasympathomimetics / Q000494:pharmacology; D012130:Respiratory Hypersensitivity / Q000139:chemically induced / Q000503:physiopathology*; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology*; D013147:Spirometry
D010277:Parasympathomimetics; D016210:Methacholine Chloride