Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors.
Second malignancies occur in 2-3% of survivors of pediatric osteosarcoma; treatment-related hematologic and solid malignancies have both been described. We present two cases of patients with pulmonary nodules that developed more than 2 years after treatment of osteosarcoma. Both lesions were completely resected and pathology revealed bronchioloalveolar carcinoma (BAC). Primary BAC is extremely rare in children; however, cases of this malignancy have been described in survivors of pediatric cancer. BAC may present as a solitary pulmonary nodule indistinguishable from a metastatic lesion and should be included in the differential diagnosis of pulmonary nodules in survivors of pediatric cancer.
Lebensburger
Jeffrey
J
Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. jeffreylebensburger@stjude.org
Katzenstein
Howard
H
Jenkins
Jesse J
JJ
Rodriguez-Galindo
Carlos
C
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000209:etiology* / Q000473:pathology; D001859:Bone Neoplasms / Q000628:therapy*; D002648:Child; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology*; D012516:Osteosarcoma / Q000628:therapy*; D017741:Survivors