Phactr2 and Parkinson's disease.
Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P=0.032), Canadian (OR: 1.41, P=0.014) and Irish (OR: 1.44, P=0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P=0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P<0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.
Wider
Christian
C
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Lincoln
Sarah J
SJ
Heckman
Michael G
MG
Diehl
Nancy N
NN
Stone
Jeremy T
JT
Haugarvoll
Kristoffer
K
Aasly
Jan O
JO
Gibson
J Mark
JM
Lynch
Timothy
T
Rajput
Alex
A
Rajput
Michele L
ML
Uitti
Ryan J
RJ
Wszolek
Zbigniew K
ZK
Farrer
Matthew J
MJ
Ross
Owen A
OA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008840:Microfilament Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009664:Norway / Q000453:epidemiology; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult
D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; C543104:PHACTR2 protein, human