Highly enantioselective catalytic alkyl propiolate addition to aliphatic aldehydes.
A novel H(8)BINOL-based chiral ligand (S)-3 is found to catalyze the alkyl propiolate addition to aliphatic aldehydes in the presence of ZnEt(2) and Ti(O(i)Pr)(4) at room temperature with excellent enantioselectivity (89-97% ee).
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.
Mark
M
Turlington
Albert M
AM
DeBerardinis
Lin
L
Pu