[Chemoprevention in head and neck cancer and lung cancer].
Because of their raised prevalence and mortality, association of secondary tumors and inefficiency of therapeutic conventional (surgery, radio- and chemotherapy), head and neck and lung cancers represent true public health problems. The knowledge of the process of carcinogenesis allowed development of approaches of chemoprevention. The vitamin A and its derivatives showed initially a certain efficacy, but an important toxicity and large trials remained negative. For lung cancers, in the event of continuation of the tobacco, beta-carotene and the vitamin A seem even deleterious. Progress in the biology of cancer should allow innovating new approaches of chemoprevention. Today the most effective strategy stays the stop of the tobacco.
Département de Médecine, Centre Léon-Bérard, 28 Rue Laennec, 69008 Lyon, France. fayette@lyon.fnclcc.fr
J
J
Fayette
L
L
Kiakouama
D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics; D020868:Gene Silencing; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000517:prevention & control*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000517:prevention & control*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D016540:Smoking Cessation; D000074606:Smoking Prevention
D016588:Anticarcinogenic Agents; D009363:Neoplasm Proteins; D066246:ErbB Receptors