CA-125 and CRP are elevated in preeclampsia.
OBJECTIVE
To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia.


METHODS
The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were used to monitor the severity of disease. CRP and CA-125 levels were determined. The cut-offs for CRP and CA-125 were 5 mg/L and 35 IU/ml. The t-test, Pearson correlation and ANOVA were used for statistical analysis. Values of p < 0.05 were considered to be significant.


RESULTS
CRP and CA-125 parameters were significantly higher in the study group (p < 0.001), and were significantly higher in severe preeclampsia and eclampsia groups than in mild preeclampsia (p < 0.001). Significant correlations were found between CRP/MAP, CRP/albumin, CA-125/MAP and CA-125/albumin (p < 0.001).


CONCLUSIONS
CRP and CA-125 are elevating markers in preeclampsia.
Cebesoy
Fatma Bahar
FB
Obstetric and Gynecology Department, Gaziantep University Faculty of Medicine, Gaziantep/Turkey. fbcebesoy@yahoo.com
Balat
Ozcan
O
Dikensoy
Ebru
E
Kalayci
Hakan
H
Ibar
Yelda
Y
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D018394:CA-125 Antigen / Q000097:blood*; D016022:Case-Control Studies; D004461:Eclampsia / Q000097:blood*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
D018394:CA-125 Antigen; D002097:C-Reactive Protein