Adult periodontal-derived neural progenitor and stem cells. Institut fur Molekulare Diagnostik und Innovative Therapie: WO2008031451.
The application is in the field of neural stem cells (NSCs) and cellular therapy. It aims to identify and characterize neural progenitor and stem cells from adult periodontal tissue. Neural progenitor and stem cells were isolated and characterized from periodontal tissue originating from biopsies of adult patients. Adult human periodontal-derived neural progenitor and stem cells can be induced to differentiate into neuronal and glial cells, osteoblasts and cells of the periodontium. They survive and integrate when transplanted into organotypic hippocampal slice cultures. The application claims the use of periodontal neural progenitor and stem cells for cellular therapy, particularly for the treatment of the periodontal diseases and neurodegenerative diseases and neurological injuries. Periodontal tissue can be harvested with minimal invasive procedures from the patient himself, providing a promising source of tissue for NSC-based therapy and autologous transplantation.
Dublin City University, School of Biotechnology, Glasnevin, Dublin 9, Ireland. philippe.taupin@dcu.ie
Philippe
P
Taupin
D000328:Adult; D053687:Adult Stem Cells / Q000378:metabolism / Q000637:transplantation*; D002454:Cell Differentiation; D006801:Humans; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000628:therapy; D009474:Neurons / Q000378:metabolism; D010330:Patents as Topic; D010510:Periodontal Diseases / Q000628:therapy; D010513:Periodontal Ligament / Q000166:cytology* / Q000378:metabolism; D033581:Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous / Q000379:methods; D020196:Trauma, Nervous System / Q000628:therapy; D055815:Young Adult