Intensity of continuous renal replacement therapy in acute kidney injury.
The intensity of continuous renal replacement therapy (CRRT) is generally assessed on the basis of small solute clearance with dosing usually expressed in terms of total effluent volume per unit time (e.g., ml/kg/hour). Although several clinical trials have suggested an improvement in survival with higher doses of CRRT, results have not been consistent across all studies. The results of recent trials of intensity of CRRT are reviewed. The largest and most recent trials suggest that there is no additional benefit to using effluent flow rates in excess of 20 ml/kg/hour, although earlier studies suggested improved survival with doses of 35 to 45 ml/kg/hour.
Renal Section, VA Pittsburgh Healthcare System and Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, University Drive Division, Pittsburgh, PA 15240, USA. palevsky@pitt.edu
Paul M
PM
Palevsky
D058186:Acute Kidney Injury / Q000378:metabolism / Q000628:therapy*; D015314:Dialysis Solutions / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008962:Models, Theoretical; D017582:Renal Replacement Therapy / Q000379:methods*; D016896:Treatment Outcome
D015314:Dialysis Solutions