Nucleoside diphosphate kinase/Nm23 and Epstein-Barr virus.
Nm23-H1 was discovered as the first metastasis suppressor gene about 20 years ago. Since then, extensive work has contributed to understanding its role in various cellular signaling pathways. Its association with a range of human cancers as well as its ability to regulate cell cycle and suppress metastasis has been explored. We have determined that the EBV-encoded nuclear antigens, EBNA3C and EBNA1, required for EBV-mediated lymphoproliferation and for maintenance EBV genome extrachromosomally in dividing mammalian cells, respectively, target and disrupt the physiological role of Nm23-H1 in the context of cell proliferation and cell migration. This review will focus on the interaction of Nm23-H1 with the Epstein-Barr virus nuclear antigens, EBNA3C and EBNA1 and the functional significance of this interaction as it relates to EBV pathogenesis.
Department of Microbiology and Tumor Virology Program of Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA.
Masanao
M
Murakami
Rajeev
R
Kaul
Pankaj
P
Kumar
Erle S
ES
Robertson
D000956:Antigens, Viral / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D002465:Cell Movement; D049109:Cell Proliferation; D020031:Epstein-Barr Virus Infections / Q000235:genetics; D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D054778:NM23 Nucleoside Diphosphate Kinases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
D000956:Antigens, Viral; C498774:EBNA-3C, epstein-barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; D054778:NM23 Nucleoside Diphosphate Kinases; C417029:EBV-encoded nuclear antigen 1