Nociceptin-induced modulation of human T cell function.
There is an accumulating evidence for the immunoregulatory role of the neuropeptide, nociceptin/orphanin FQ (N/OFQ) however its role on T cell function requires elucidation. This study has demonstrated an inhibitory role for N/OFQ on SEB-activated T cell function. N/OFQ decreases T cell proliferation, which is abrogated when the costimulatory receptors CD80 and CD86 are blocked. In addition, evidence suggests that the immunoregulatory cytokines TGF-beta, IFN-gamma and nitric oxide (NO) are involved in the N/OFQ effect. N/OFQ also, through involvement of IFN and NO, induces the expression of the immunosuppressive modulator indoleamine 2,3-dioxygenase (IDO), suggesting a central role for IDO in the N/OFQ effect on T cell proliferation. The data presented in this report indicate a multi-faceted mechanism of action used by N/OFQ to modulate T cell function.
Faculty of Health and Life Sciences, Centre for Research in Biomedicine, University of the West of England, Coldharbour lane, Frenchay, Bristol, UK.
Kate H
KH
Easten
Rachel A
RA
Harry
Wendy M
WM
Purcell
Julie D
JD
McLeod
D000818:Animals; D016466:CHO Cells; D049109:Cell Proliferation; D006224:Cricetinae; D003412:Cricetulus; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology; D008213:Lymphocyte Activation; D009569:Nitric Oxide / Q000502:physiology; D018847:Opioid Peptides / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D016212:Transforming Growth Factor beta / Q000502:physiology; D000097629:Nociceptin
D007371:Interferon-gamma; D009569:Nitric Oxide; D018847:Opioid Peptides; D011453:Prostaglandins; D016212:Transforming Growth Factor beta; D000097629:Nociceptin