[The role of gonadal peptides in clinical investigation].
Inhibins, activins, and anti-Mullerian hormone (AMH) are gonadal dimeric peptides produced in ovaries and testes by homologous cells, granulosa cells and Sertoli cells, respectively. The production of inhibins is driven by FSH, that of AMH may indirectly depends on FSH, while it is down regulated, at least in the male, by testosterone. In the past decade, measurements of serum inhibin and AMH have provided useful tools for clinical investigation in gonadal disorders: pseudohermaphroditism, androgen insensitivity, anorchidism, gonadal dysgenesis, disorders of pubertal developpement. Inhibins, activins, and AMH are also reliable markers of gonadal tumors. They are extensively used as indexes of fertility: in the male the production of inhibin B reflects the spermatogenetic activity, in women both inhibin B and AMH levels are correlated with the number of preantral and early antral follicles and reflect the ovarian reserve of follicles available for recruitment.
Service d'hormonologie pédiatrique et maladies métaboliques, Hôpital Saint Vincent de Paul, Paris. najiba.lahlou@svp.aphp.fr
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N
Lahlou
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Bouvattier
A
A
Linglart
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D
Rodrigue
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C
Teinturier
D028341:Activins / Q000502:physiology*; D000293:Adolescent; D000375:Aging / Q000502:physiology; D054304:Anti-Mullerian Hormone / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005640:Follicle Stimulating Hormone / Q000037:antagonists & inhibitors / Q000502:physiology; D006801:Humans; D007223:Infant; D007265:Inhibins / Q000097:blood / Q000502:physiology*; D008297:Male; D010053:Ovary / Q000502:physiology; D013737:Testis / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D055815:Young Adult
D016212:Transforming Growth Factor beta; D028341:Activins; D007265:Inhibins; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone