Non Lewis acid catalysed epoxide ring opening with amino acid esters.
The ring opening of epoxides by various amino acid esters is described in refluxing trifluoroethanol without any catalyst. Under these simple conditions the corresponding beta-amino alcohols are obtained in good to excellent yields in relatively short reaction times compared to previously reported methods.
Philippe
Christine
C
Laboratoire BioCIS-CNRS, Faculté de Pharmacie, Univ. Paris-Sud, rue J. B. Clément, F-92296 Châtenay-Malabry, France.
Milcent
Thierry
T
Crousse
Benoit
B
Bonnet-Delpon
Danièle
D
D000596:Amino Acids / Q000737:chemistry*; D000605:Amino Alcohols / Q000138:chemical synthesis*; D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D015394:Molecular Structure; D014270:Trifluoroethanol / Q000737:chemistry
D000596:Amino Acids; D000605:Amino Alcohols; D004852:Epoxy Compounds; D004952:Esters; D014270:Trifluoroethanol