Ure(k)a! Sirtuins Regulate Mitochondria.
Increasing evidence suggests that multiple metabolic pathways are regulated by sirtuin-dependent protein deacetylation in the mitochondria. In this issue, Nakagawa et al. (2009) show that the sirtuin SIRT5 deacetylates and activates a mitochondrial enzyme, carbamoyl phosphate synthetase 1, which mediates the first step in the urea cycle.
Hallows
William C
WC
Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, 53706, USA.
Smith
Brian C
BC
Lee
Susan
S
Denu
John M
JM
D000818:Animals; D002222:Carbamoyl-Phosphate Synthase (Ammonia) / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D037761:Sirtuins / Q000378:metabolism*
D024101:Mitochondrial Proteins; D037761:Sirtuins; D002222:Carbamoyl-Phosphate Synthase (Ammonia)