Advancements in adenoviral based virotherapy for ovarian cancer.
Ovarian cancer is a leading gynecologic malignancy with relatively grim survival statistics. There is a significant need for the development of new treatment options for this malignancy. The development of virotherapy as a treatment option for ovarian cancer has the potential to improve patient survival. Adenoviruses have multiple advantages as vectors for virotherapy including a well-understood structure and the ability to infect cells easily. We will outline the advances in virotherapy in the treatment of ovarian cancer, with particular attention directed toward adenoviral vectors.
Matthews
Kellie S
KS
The Division of Gynecologic Oncology, The University of Alabama at Birmingham, 619 19th Street South, OHB 534, Birmingham, AL 35213, USA. ksmatthews13@gmail.com
Alvarez
Ronald D
RD
Curiel
David T
DT
D000256:Adenoviridae / Q000235:genetics*; D003131:Combined Modality Therapy; D005260:Female; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D007274:Injections, Intraperitoneal; D050130:Oncolytic Virotherapy; D010051:Ovarian Neoplasms / Q000235:genetics / Q000628:therapy*