Comparative study of the neuropeptide-Y sympathetic nerves in endometriotic involved and noninvolved sacrouterine ligaments in women with pelvic endometriosis.
OBJECTIVE
To show the relationship between the neuropeptide-Y pelvic sympathetic nerves and neoangiogenesis in the development of endometriosis


METHODS
Prospective study.


METHODS
Academic community teaching hospital.


METHODS
Fifteen consecutive women with unilateral endometriotic infiltration of the sacrouterine ligaments.


METHODS
A laparoscopic excision/biopsy of involved and noninvolved parts of the sacrouterine ligaments were taken. The sections were incubated with the neuronal marker rabbit polyclonal anti-protein gene product 9.5 and rabbit polyclonal anti-neuropeptide-Y. We made a comparative study on the distribution of nerve fibers and their relationship to the vessels on intact and endometriotic involved tissue.


RESULTS
The results show that a large amount of nerves are present around the blood vessels in the endometriosis samples, and a large number of these nerves are neuropeptide-Y sympathetic nerves. Adrenergic fibers are also present in the intact control subjects, however, in significantly smaller amounts.


CONCLUSIONS
This finding shows a strong relationship between the neuropeptide-Y sympathetic pelvic nerves and the neoangiogenesis required for the development of endometriosis.
Possover
Marc
M
Department of Advanced Surgical Gynaecology & Neuropelveology, Hirslanden Clinic, Zurich, Switzerland. Marc.Possover@hirslanden.ch
Tersiev
Plamen
P
Angelov
Doychin N
DN
D000328:Adult; D001706:Biopsy; D004715:Endometriosis / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008022:Ligaments / Q000098:blood supply* / Q000294:innervation / Q000601:surgery; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D009478:Neuropeptide Y / Q000502:physiology*; D017699:Pelvic Pain; D011446:Prospective Studies; D013564:Sympathetic Nervous System / Q000098:blood supply*; D055815:Young Adult
D009478:Neuropeptide Y