Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart.
In this study, we review the development and application of multi-physics and multi-scale coupling in the construction of whole-heart physiological models. Through an examination of recent computational modelling developments, we analyse the significance of coupling mechanisms for the increased understanding of cardiac function in the areas of excitation-contraction, coronary blood flow and ventricular fluid mechanical coupling. Within these physiological domains, we demonstrate and discuss the importance of model parametrization, imaging-based model anatomy and computational implementation.
Oxford University Computing Laboratory, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, UK.
Jack
J
Lee
Steven
S
Niederer
David
D
Nordsletten
Ian
I
Le Grice
Bruce
B
Smaill
Bruce
B
Smail
David
D
Kay
Nicolas
N
Smith
D003331:Coronary Vessels / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans