[Case of double cancer of the liver, cholangiocarcinoma and hepatocellular carcinoma detected in a patient with hepatitis C 13 years after diminution of HCV-RNA by interferon treatment].
A 56-year-old man with chronic hepatitis C (HCV) was treated with interferon therapy and achieved sustained virological response (SVR) in 1993. Thirteen years later, in 2006 two liver tumors, 35-mm and 11-mm in diameter respectively, were detected in liver segment 6. Hepatic resection was performed, and pathologically one nodule was diagnosed as cholangiocellular carcinoma (CCC) and the other hepatocellular carcinoma (HCC). Continuity was not recognized between these tumors, thus, we diagnosed this case as double cancer (CCC and HCC). Here, we report a rare case of double cancer (CCC and HCC) that developed 13 years after achieving SVR for HCV infection.
Tsumura
Takako
T
Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University.
Takaki
Shintaro
S
Aikata
Hiroshi
H
Kimura
Yuki
Y
Katamura
Yoshio
Y
Azakami
Takahiro
T
Kawaoka
Tomokazu
T
Tsuge
Masataka
M
Sanetou
Hiromi
H
Waki
Koji
K
Hiramatsu
Akira
A
Imamura
Michio
M
Kawakami
Yoshiiku
Y
Takahashi
Shoichi
S
Arihiro
Koji
K
Chayama
Kazuaki
K
D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D012367:RNA, Viral / Q000097:blood; D013997:Time Factors
D015415:Biomarkers; D016898:Interferon-alpha; D012367:RNA, Viral