A novel mode of FoxM1 regulation: positive auto-regulatory loop.
Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-regulation of FoxM1.
Halasi
Marianna
M
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Gartel
Andrei L
AL
D045744:Cell Line, Tumor; D025461:Feedback, Physiological; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010455:Peptides / Q000494:pharmacology; D012333:RNA, Messenger / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013883:Thiostrepton / Q000494:pharmacology
C107585:FOXM1 protein, human; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors; D010455:Peptides; D012333:RNA, Messenger; D011993:Recombinant Fusion Proteins; C024711:siomycin A; D013883:Thiostrepton