Do synovial biopsies help to support evidence for involvement of innate immunity in the immunopathology of Behçet's disease?
Behçet's disease is a complex vasculitis of unknown etiology. Abundant neutrophils suggest the involvement of innate immunity. Cytokines are skewed to the T-helper-1 pattern. Few sterile organs are easily accessible for analysis in Behçet's disease. Cañete and coworkers identify inflamed joints as a feasible model and suggest the involvement of innate immunity in Behçet's disease.
van Laar
Jan A M
JA
Kappen
Jasper H
JH
van Daele
Paul L A
PL
van Hagen
P Martin
PM
D001528:Behcet Syndrome / Q000276:immunology*; D001706:Biopsy; D006801:Humans; D007113:Immunity, Innate; D000074402:Synovectomy; D013583:Synovial Membrane / Q000276:immunology*