[Life span sexual dimorphism].
The most of the studied species have extended life span of females compared to males. This is due to increased extrinsic (behavioral-independent) and intrinsic (age-related) mortality ratio of males. Evolutionary theory predicts that high rate of extrinsic mortality should increase the rate of aging. We suggest testing the evolutionary theory by estimation of male life span in Drosophila sex behavioral mutants. The intrinsic mortality ratio may be affected by hormonal signals from gonads, which modify insulin/IGF-1 signaling by sex-specific mode. Investigation of life span in flies mutant in insulin/IGF-1 signaling pathway may help to understand the molecular mechanism of sex differences in lifespan.
Shaposhnikov
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D000818:Animals; D004331:Drosophila melanogaster / Q000502:physiology*; D005260:Female; D007328:Insulin / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008136:Longevity; D008297:Male; D008954:Models, Biological; D012727:Sex Characteristics; D015398:Signal Transduction
D007328:Insulin; D007334:Insulin-Like Growth Factor I