NF-kappaB regulation: the nuclear response.
Nuclear factor kappaB (NF-kappaB) is an inducible transcription factor that tightly regulates the expression of a large cohort of genes. As a key component of the cellular machinery NF-kappaB is involved in a wide range of biological processes including innate and adaptive immunity, inflammation, cellular stress responses, cell adhesion, apoptosis and proliferation. Appropriate regulation of NF-kappaB is critical for the proper function and survival of the cell. Aberrant NF-kappaB activity has now been implicated in the pathogenesis of several diseases ranging from inflammatory bowel disease to autoimmune conditions such as rheumatoid arthritis. Systems governing NF-kappaB activity are complex and there is an increased understanding of the importance of nuclear events in regulating NF-kappaB's activities as a transcription factor. A number of novel nuclear regulators of NF-kappaB such as IkappaB-zeta and PDZ and LIM domain 2 (PDLIM2) have now been identified, adding another layer to the mechanics of NF-kappaB regulation. Further insight into the functions of these molecules raises the prospect for better understanding and rational design of therapeutics for several important diseases.
Department of Clinical Medicine and Institute of Molecular Medicine, Trinity College, Dublin, Ireland. Arun.Mankan@lrz.tum.de
Arun K
AK
Mankan
Matthew W
MW
Lawless
Steven G
SG
Gray
Dermot
D
Kelleher
Ross
R
McManus
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
D018832:Molecular Chaperones; D016328:NF-kappa B