Retinoids: new use by innovative drug-delivery systems.
BACKGROUND
Retinoids represent an old class of bioactives used in the treatment of different skin pathologies (such as acne and psoriasis) and in the treatment of many tumors. Unfortunately, they present several side effects, i.e., burning of skin and general malaise after systemic administration and they are very unstable after exposition to light.


METHODS
One of the most promising new approaches for reducing the side effects of retinoids while improving their pharmacological effect is the use of drug-delivery devices. This review explains the current status of retinoid drug transport, which has been developing over the last few years, explaining the modification of their biopharmaceutical properties in detail after encapsulation/inclusion in vesicular and polymeric systems.


CONCLUSIONS
Different colloidal and micellar systems containing retinoid drugs have been realized furnishing important potential advancements in traditional therapy.
Trapasso
E
E
University of Messina, Pharmacochemistry Department, University of Messina, Italy.
Cosco
D
D
Celia
C
C
Fresta
M
M
Paolino
D
D
D000818:Animals; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008081:Liposomes; D008958:Models, Molecular; D053758:Nanoparticles; D011108:Polymers; D012176:Retinoids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*
D004337:Drug Carriers; D008081:Liposomes; D011108:Polymers; D012176:Retinoids