Novel one-pot, three-component synthesis of spiro[indoline-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]trione library.
A one-pot method for the efficient and simple synthesis of the novel spiro[indoline-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]trione derivatives by a three-component condensation reaction of barbituric acids, 1H-pyrazol-5-amines and isatins in aqueous media is reported.
Ghahremanzadeh
Ramin
R
Department of Chemistry, Shahid Beheshti University, Tehran, Iran.
Sayyafi
Maryam
M
Ahadi
Somayeh
S
Bazgir
Ayoob
A
D001463:Barbiturates / Q000138:chemical synthesis / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D007510:Isatin / Q000138:chemical synthesis / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
C542126:1H-pyrazol-5-amine; D001463:Barbiturates; D011720:Pyrazoles; D011744:Pyrimidinones; D013141:Spiro Compounds; C542062:spiro(indoline-pyrazolo(4',3'-5,6)pyrido(2,3-d)pyrimidine)trione; D014867:Water; D007510:Isatin; C032232:barbituric acid