[Using marker of the mitochondrial pore opening in diagnostics of patients with myocardial ischemic lesions].
In the article a possibility of definition of level of the mitochondrial factor (MF) for early diagnostics of the myocardial ischemic damages at patients during heart surgery was investigated. The reperfusion damages of heart were manifested by MPTP activation and MF release. The rising of MF level during a cardioplegia is comparable to level, which has been noted at patients with angina before operation of aorto-coronary shunting. The beginning of reperfusion, practically did not change MF level, but 5 minutes after restoration of a blood flow and warm reductions it increased to the maximum values. Thus, it closely correlated with a level of a myocardial contractility depression and data of biochemical researches, which are traditionally used in clinic for diagnostics of damages of a heart. It allows to confirm, what exactly reperfusion is a major factor damaging of a myocardium. Its important that, change of MF level we registered at first minutes of heart reperfusion, those are much earlier, than by means of other markers. It seems to us, that investigation of a MF is very perspective for early finding of an ischemic damages of different tissues and organs.
Sahach
V F
VF
Dmytriieva
A V
AV
Bubnova
Iu O
IuO
Maksymenko
V B
VB
Knyshov
H V
HV
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D006348:Cardiac Surgical Procedures; D003326:Coronary Circulation; D042241:Early Diagnosis; D006801:Humans; D007431:Intraoperative Complications / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D008875:Middle Aged; D008929:Mitochondria, Heart / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000097:blood*; D000083162:Mitochondrial Permeability Transition Pore; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D055815:Young Adult
D015415:Biomarkers; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore