Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy.
Bacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)-gamma response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK adolescents, but not in Malawian adolescents. We hypothesized that Mtb PPD-induced IFN-gamma after BCG vaccination would be similar in infants from these 2 countries. Infants were vaccinated with BCG during the first 3-13 weeks of life. Three months after BCG vaccination, 51 (100%) of 51 UK infants had an IFN-gamma response to Mtb PPD, compared to 41 (53%) of 78 of Malawian infants, in whom responses varied according to their season of birth. We conclude that population differences in immune responses after BCG vaccination are observed among infants, as well as among young adults.
Lalor
Maeve K
MK
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom. maeve.lalor@lshtm.ac.uk
Ben-Smith
Anne
A
Gorak-Stolinska
Patricia
P
Weir
Rosemary E
RE
Floyd
Sian
S
Blitz
Rose
R
Mvula
Hazzie
H
Newport
Melanie J
MJ
Branson
Keith
K
McGrath
Nuala
N
Crampin
Amelia C
AC
Fine
Paul E M
PE
Dockrell
Hazel M
HM
D001500:BCG Vaccine / Q000276:immunology* / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007371:Interferon-gamma / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000276:immunology; D006113:United Kingdom; D014611:Vaccination
D001500:BCG Vaccine; D007371:Interferon-gamma