An optical approach for drug screening based on light-harvesting conjugated polyelectrolytes.
Drugs turn the light off: Conjugated polyelectrolytes (CPEs) have been used in fluorescent assays for real-time screening of small molecules that prevent the RNA-protein complexation that is important for virus replication and thereby can be considered potential initial candidates for drug discovery (see picture).
An
Lingling
L
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, PR China.
Liu
Libing
L
Wang
Shu
S
Bazan
Guillermo C
GC
D004353:Drug Evaluation, Preclinical; D004573:Electrolytes / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry; D005601:Framycetin / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D004573:Electrolytes; D005456:Fluorescent Dyes; D010455:Peptides; D005601:Framycetin; D012313:RNA