Therapy related CMML: a case report and review of the literature.
Therapy related chronic myelomonocytic leukemia (t-CMML) is rare. We report a 23-year-old female who developed acute fulminant hepatic failure after drug overdose. She underwent ABO incompatible orthotopic liver transplant. She received cyclophosphamide along with other immunosuppressants. Seven years later, she was diagnosed with t-CMML-2 with 45XX,-7 karyotype. She received 4 cycles of azacitidine and proceeded with allogeneic bone marrow transplant. This is the first a case of t-CMML reported in a liver transplant recipient. In this article, we also summarize all reported cases of t-CMML, and we review therapy related MDS in recipients of solid organ transplant.
Department of Internal Medicine, Hematology and Medical Oncology Division, University of Cincinnati, Cincinnati, OH, USA.
Faheem
F
Ahmed
Nadia
N
Osman
Fred
F
Lucas
Guy
G
Neff
Teresa
T
Smolarek
John M
JM
Bennett
Rami S
RS
Komrokji
D001374:Azacitidine / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000009:adverse effects; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015477:Leukemia, Myelomonocytic, Chronic / Q000139:chemically induced* / Q000628:therapy; D017114:Liver Failure, Acute / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D055815:Young Adult
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D001374:Azacitidine