Gas-phase ion chemistry of protonated melatonin.
The gas-phase ion chemistry of protonated melatonin has been investigated by mass spectrometric (MS) techniques involving chemical ionisation, fast atom bombardment and electrospray ionisation. Either naturally- occurring or collision-induced decomposition e-D derivatives obtained by exchange with D(2)O. The analysis of experimental results allows definite pathways for the formation of the ion at m/z 174 to be assigned and sheds some more light on the overall fragmentation pathways. Experiments on labelled derivatives evidenced H-D scrambling processes during fragmentation.
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Palermo, Via Archirafi 32, I-90123 Palermo, Italy.
David
D
Bongiorno
Leopoldo
L
Ceraulo
Lorenzo
L
Camarda
Maurizio
M
Ciofalo
Mirella
M
Ferrugia
Serena
S
Indelicato
Andrea
A
Mele
Vincenzo Turco
VT
Liveri
D000081:Acetamides / Q000737:chemistry; D000641:Ammonia / Q000737:chemistry; D041961:Deuterium Exchange Measurement; D005740:Gases / Q000737:chemistry; D007477:Ions / Q000737:chemistry*; D008550:Melatonin / Q000737:chemistry*; D011522:Protons; D011789:Quantum Theory; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
D000081:Acetamides; D005740:Gases; D007477:Ions; D011522:Protons; D000641:Ammonia; C030686:acetamide; D008550:Melatonin