Prognosis and predictors of convulsion among pediatric lupus nephritis patients.
In this study, we aimed to analyze features and outcome of convulsion in pediatric lupus nephritis patients. We retrospectively reviewed data of 14 Iranian children with lupus nephritis who developed seizures and compared them with a group of the same number of well matched pediatric lupus nephritis patients. Higher serum creatinine levels and higher frequencies of anemia and lymphopenia were observed in the convulsion group. Multivariable logistic regression analysis revealed that the only risk factor for development of convulsion in pediatric lupus patients with nephritis was lymphopenia. Survival analysis showed that convulsion had no impact on patient and renal function outcomes in our pediatric lupus nephritis subjects. In conclusion, we found that lymphopenia is a predictive factor for convulsion occurrence in our patients and special attention to neurological status assessment may be needed in this situation.
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Fatemeh
F
Beiraghdar
Abbas
A
Maddani
Saeed
S
Taheri
Mir Mohsen
MM
Sharifi-Bonab
Taher
T
Esfahani
Yunes
Y
Panahi
Behzad
B
Einollahi
D000293:Adolescent; D000740:Anemia / Q000150:complications; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008181:Lupus Nephritis / Q000097:blood / Q000150:complications* / Q000401:mortality; D008231:Lymphopenia / Q000097:blood / Q000150:complications*; D008297:Male; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012640:Seizures / Q000097:blood / Q000209:etiology* / Q000401:mortality; D013997:Time Factors; D015854:Up-Regulation
D015415:Biomarkers; D003404:Creatinine