ING proteins in cellular senescence.
Cellular senescence is an effective anti-tumor barrier that acts by restraining the uncontrolled proliferation of cells carrying potentially oncogenic alterations. ING proteins are putative tumor suppressor proteins functionally linked to the p53 pathway and to chromatin regulation. ING proteins exert their tumor-protective action through different types of responses. Here, we review the evidence on the participation of ING proteins, mainly ING1 and ING2, in the implementation of the senescent response. The currently available data support an important role of ING proteins as regulators of senescence, in connection with the p53 pathway and chromatin organization.
Instituto de Investigaciones Biomédicas CSIC-UAM. Arturo Duperier, 4. 28029 Madrid, Spain.
Camino
C
Menéndez
María
M
Abad
Daniel
D
Gómez-Cabello
Alberto
A
Moreno
Ignacio
I
Palmero
D000818:Animals; D049109:Cell Proliferation; D016922:Cellular Senescence / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
D002843:Chromatin; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins