Finding new core promoter elements using backward-looking strategies.
Core Promoter Elements (CPEs) were key players in transcription initiation. Identifying CPEs is crucial for understanding gene expression. In this paper, a framework for finding new CPEs was proposed. An experiment was performed on the sequences of Eukaryotic Promoter Database (EPD). From the results, the known CPEs were all recovered; in addition, five new motifs were discovered in Drosophila and three in human. By comparing the results with currently known CPEs, it is shown that the proposed system is feasible and reliable, and these new CPEs are worth of further exploration.
Huang
Yin-Fu
YF
Graduate School of Computer Science and Information Engineering, National Yunlin University of Science and Technology, 123 University Road, Section 3, Touliu, Yunlin, Taiwan 640, ROC. huangyf@el.yuntech.edu.tw
Jhan
Yi-Chao
YC
Liou
Sing-Wu
SW
D001483:Base Sequence; D003628:Database Management Systems; D030541:Databases, Genetic; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods*; D015533:Transcriptional Activation / Q000235:genetics*