Identification of Hsp70 modulators through modeling of the substrate binding domain.
The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described. The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology.
Department of Pharmacy, University of Pittsburgh, Pittsburgh, USA.
Conor M
CM
Haney
Corinne
C
Schneider
Barbara
B
Beck
Jeffrey L
JL
Brodsky
Alexander
A
Dömling
D000595:Amino Acid Sequence; D001665:Binding Sites; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry* / Q000378:metabolism; D008956:Models, Chemical; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011485:Protein Binding; D017434:Protein Structure, Tertiary
D018840:HSP70 Heat-Shock Proteins; D010455:Peptides