Investigations on topically applied vitamin A loaded amphiphilic cyclodextrin nanocapsules.
A new cholesteryl-cyclodextrin derivative, obtained by grafting a single cholesterol on a cyclodextrin, was proved suitable for the manufacture of nanocapsules. The chemical structure of Chol-betaCD-Ac was assessed using high resolution 1H-NMR. These nanocapsules were loaded with a lipophilic drug, i.e., vitamin A propionate (PRVA) which is a highly unstable and poorly water soluble molecule with a real interest in therapeutic. The oily nature of vitamin A propionate leads to the formation of nanocapsules with a reproductible size distribution and a long term stability. The colloidal suspension can be used to form a gel which allow to achieve penetration in the skin of the PRVA encapsulated.
Weisse
Sandrine
S
Service de Chimie Moléculaire, DSM/DRECAM, CEA Saclay, 91191 Gif sur Yvette Cedex, France.
Kalimouttou
Sendilcoumare
S
Lahiani-Skiba
Malika
M
Djedaini-Pilard
Florence
F
Perly
Bruno
B
Skiba
Mohamed
M
D000287:Administration, Topical; D003460:Crystallization / Q000379:methods; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D066298:In Vitro Techniques; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D012867:Skin / Q000378:metabolism*; D013499:Surface Properties; D014801:Vitamin A / Q000008:administration & dosage* / Q000737:chemistry*
D003505:Cyclodextrins; D004337:Drug Carriers; D046911:Macromolecular Substances; D014801:Vitamin A