Two base pair duplexes suffice to build a novel material.
Tetrahedral DNA hybrids with tetrakis(p-hydroxyphenyl)methane cores hybridize in a sequence-specific fashion at much higher temperatures than isolated linear duplexes. Dinucleotide DNA arms suffice to induce the formation of a solid at room temperature; this demonstrates the strength of multivalent binding. The graphic shows a view of a modeled assembly.
Institut für Organische Chemie and Center for functional Nanostructures, Universität Karlsruhe (TH), 76131 Karlsruhe, Germany.
Martin
M
Meng
Carolin
C
Ahlborn
Matthias
M
Bauer
Oliver
O
Plietzsch
Shahid A
SA
Soomro
Arunoday
A
Singh
Thierry
T
Muller
Wolfgang
W
Wenzel
Stefan
S
Bräse
Clemens
C
Richert
D020029:Base Pairing; D001593:Benzyl Compounds / Q000737:chemistry*; D003460:Crystallization; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D044366:Transition Temperature
D001593:Benzyl Compounds; D005456:Fluorescent Dyes; D009841:Oligonucleotides; C542267:tetrakis(p-hydroxyphenyl)methane; D004247:DNA