Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis.
Despite considerable progress in understanding the function of peroxiredoxin (Prx) in cancer, its expression patterns have not been extensively studied in response to cervical carcinogenesis. We evaluated the expression of Prx isoforms in normal tissue, cervical intraepithelial neoplasia (CIN1, CIN2, and CIN3), and cervical cancer. We found strong pattern of increased Prx II and III immunostaining with increasing severity of the lesion. No difference in staining intensity by grade of lesion was observed for Prx I, and IV. Therefore, we conclude that Prx II and III are upregulated in response to the development of cervical cancer.
Kim
Kiyoon
K
Department of Biochemistry and Molecular biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyunghee University School of Medicine, Seoul 130-701, Korea.
Yu
Miran
M
Han
Seulhee
S
Oh
Inkyung
I
Choi
Young-Jun
YJ
Kim
Sungsoo
S
Yoon
Kyungsik
K
Jung
Minhyung
M
Choe
Wonchae
W
D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D009367:Neoplasm Staging; D061105:Peroxiredoxin III; D054464:Peroxiredoxins / Q000032:analysis*; D046888:Tissue Array Analysis; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000201:enzymology* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000201:enzymology* / Q000473:pathology
D014408:Biomarkers, Tumor; D007527:Isoenzymes; C515940:PRDX1 protein, human; C086065:PRDX2 protein, human; C516115:PRDX3 protein, human; C515980:PRDX4 protein, human; D061105:Peroxiredoxin III; D054464:Peroxiredoxins