Glucose responsive hydrogel networks based on protein recognition.
Stimuli-responsive materials capable of manifesting physical changes in response to environmental signals are valuable tools for use in a variety of biomedical applications. Herein we describe one such smart glucose-responsive hydrogel material prepared by immobilizing the glucose/galactose binding protein within an acrylamide hydrogel network. This hydrogel demonstrates a quantitative "accordion"-like dynamic response in the presence of glucose. We further show the feasibility of employing this responsive smart material as a gating agent for controlled drug delivery, thus, demonstrating that these hydrogels may eventually lead to the development of implantable drug delivery systems for diabetes management applications.
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
Jason D
JD
Ehrick
Matthew R
MR
Luckett
Santoshkumar
S
Khatwani
Yinan
Y
Wei
Sapna K
SK
Deo
Leonidas G
LG
Bachas
Sylvia
S
Daunert
D015374:Biosensing Techniques / Q000379:methods*; D016503:Drug Delivery Systems; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics; D005947:Glucose / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics; D008958:Models, Molecular; D009004:Monosaccharide Transport Proteins / Q000737:chemistry / Q000235:genetics; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*
D029968:Escherichia coli Proteins; D020100:Hydrogels; D008562:Membrane Glycoproteins; D009004:Monosaccharide Transport Proteins; D011506:Proteins; D005947:Glucose