Cyclodextrin polymers as efficient solubilizers of albendazole: complexation and physico-chemical characterization.
The inclusion behavior of natural cyclodextrins (CDs) and polymers based on natural cyclodextrins (CD-polymer), in solution and in solid-state, was studied towards a poorly water-soluble anti-helminthic drug, albendazole (ABZ), chemically methyl[5-(propylthio)-1-H-benzimidazol-2yl]carbamate. Drug-cyclodextrin solid systems were prepared by freeze-drying. Phase solubility study was used to evaluate the interaction in solution, between ABZ/(CDs) and ABZ/CD-polymers. The stability constants of ABZ/natural CDs and ABZ/CD-polymers complexes were calculated by phase solubility method. The apparent solubility of Albendazole was enhanced especially with poly alpha-CD. The formation of inclusion complexes with natural CDs and polymers of cyclodextrin in the solid-state form were confirmed by Fourier Fransform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR).
Laboratoire de Pharmacie Galénique, ADEN EA 3234, UFR Médecine and Pharmacie, 22 BD Gambetta, 76183 Rouen, France.
Samer
S
Joudieh
Pierre
P
Bon
Bernard
B
Martel
Mohamed
M
Skiba
Malika
M
Lahiani-Skiba