Tolerogenic dendritic cell-regulatory T-cell interaction and the promotion of transplant tolerance.
Evidence has accumulated that targeting of donor alloantigen to quiescent dendritic cells (DC) in situ or adoptive DC therapy is associated with the expansion or induction of regulatory T cells (Treg) in experimental organ transplantation. These Treg can mediate suppression of antidonor T-effector cell responses and promote allograft tolerance. In addition, Treg can exert reciprocal, inhibitory effects on DC that maintain their tolerogenic properties. Several groups have exploited DC to expand allo-Ag-specific Treg in vitro, followed by adoptive transfer of the Treg to graft recipients, an approach that holds promise for tolerogenic cell therapy in clinical cell and organ transplantation.
Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA. thomsonaw@upmc.edu
Angus W
AW
Thomson
Hēth R
HR
Turnquist
Alan F
AF
Zahorchak
Giorgio
G
Raimondi
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000637:transplantation; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D016377:Organ Transplantation / Q000379:methods; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000276:immunology; D023001:Transplantation Tolerance / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D016212:Transforming Growth Factor beta; D016753:Interleukin-10