The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study.
OBJECTIVE
To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats.


METHODS
Male Sprague-Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The brains of animals were surgically removed and immunohistochemically stained for serotonin. Serotonin-positive stained cells were counted automatically by using a computerized image analysis program. Statistical analysis carried out using one-way ANOVA followed by post hoc Tukey test.


RESULTS
A significant decrease in serotonin-positive cells in the brainstem was observed after chronic sumatriptan administration while chronic use of dipyrone induced a significant increase in serotonin-positive cells both in the cortex and midbrain.


CONCLUSIONS
Our data suggest that central serotonergic system might be modified by chronic use of sumatriptan and dipyrone.
Genç
E
E
Department of Neurology, Meram School of Medicine, Selcuk University, Konya, Turkey. eminegencduran@gmail.com
Avunduk
M C
MC
Genç
B Oğuz
BO
Sahin
A Saide
AS
Oz
M
M
D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D004177:Dipyrone / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D018170:Sumatriptan / Q000008:administration & dosage / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D017366:Serotonin Receptor Agonists; D004177:Dipyrone; D018170:Sumatriptan