[Antioxidant gene polymorphism and longevity].
On sample of 1534 ethnic Tatars catalase (CAT, -262C/T), glutathione peroxidase 1 (GPX1, L198P) and methionine sulfoxide reductase A (MSRA, -402C/T) gene polymorphisms in connection with lifespan were studied. On each separate polymorphic marker nonlinear character of alleles and genotypes frequencies changes with age was revealed. Combinations of genotypes CAT*C/*T-GPX1 *L/*L were significant for elderly and senile age.
Pauk
V V
VV
Nasibullin
T R
TR
Tuktarova
I A
IA
Zueva
L P
LP
Mustafina
O E
OE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D044466:Asian People; D002374:Catalase / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D007223:Infant; D008136:Longevity / Q000235:genetics*; D008297:Male; D051150:Methionine Sulfoxide Reductases; D008875:Middle Aged; D010088:Oxidoreductases / Q000235:genetics*; D055815:Young Adult; D000094765:Glutathione Peroxidase GPX1
D000975:Antioxidants; D010088:Oxidoreductases; D002374:Catalase; D005979:Glutathione Peroxidase; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human