Ovarian serous adenocarcinoma identified during IVF: diagnostic approach, surgical management, and reproductive outcome.
BACKGROUND
To present a diagnostic evaluation and treatment strategy for serous adenocarcinoma of the ovary discovered during an in vitro fertilisation (IVF) sequence, and report on reproductive outcome after tumour resection and embryo transfer.


METHODS
Cycle monitoring in IVF identified an abnormal ovarian lesion which was subjected to ultrasound-guided needle aspiration. Cytology suggested malignancy, and unilateral oophorectomy was performed after formal staging. After surgery, the patient underwent an anonymous donor oocyte IVF cycle which established a viable twin intrauterine pregnancy. No recurrence of cancer has been detected in the >72 month follow-up interval; mother and twin daughters continue to do well.


CONCLUSIONS
Suspicious adnexal structures noted during controlled ovarian hyperstimulation for IVF warrant assessment, and this report confirms the role of aspiration cytology in such cases. If uterine conservation is possible, successful livebirth can be achieved from IVF if donor oocyes are utilised, as described here.
Department of Obstetrics and Gynaecology, Division of Reproductive Endocrinology and Infertility, School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland. drdavidwalsh@sims.ie
David J
DJ
Walsh
Eric Scott
ES
Sills
Lyuda V
LV
Shkrobot
Noreen C
NC
Gleeson
Mary N
MN
Sheppard
Anthony P H
AP
Walsh
D000328:Adult; D018284:Cystadenocarcinoma, Serous / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000601:surgery*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000601:surgery*