Nickel-catalyzed decarboxylative carboamination of alkynes with isatoic anhydrides.
An intermolecular nickel-catalyzed addition reaction in which isatoic anhydrides react with alkynes to afford substituted quinolones has been developed. A mechanistic rationale is proposed, implying oxidative addition of Ni(0) to a carbamate, which allows intermolecular addition to alkynes via decarboxylation.
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Yasufumi
Y
Yoshino
Takuya
T
Kurahashi
Seijiro
S
Matsubara