Sexual function in adult male rats after prenatal modulation of the cholinergic system.
Prenatal administration of the n-cholinolytic ganglerone to pregnant female rats at different periods of gestation was found to lead to long-term changes in sexual behavior in pubescent offspring: there was a reduced dynamic of acquiring sexual experience and a very low level of sexual activity, with significant impairment to the motivational and ejaculatory components of sexual behavior. The number of males with reduced sexual activity in the experimental groups was significantly greater than that in control offspring. The results obtained here provide evidence that impairments of sexual function in adult offspring induced by prenatal administration of the n-cholinolytic ganglerone at 9-11 and 12-14 days of gestation and, to a lesser extent, the m-cholinolytic metamyzil at 9-11 days of gestation, were due to impairment to the central mechanisms regulating sexual function due to stable changes in neurotransmitter activity in the hippocampus and hypothalamus, along with a significant reduction in the blood testosterone level.
I. P. Pavlov St. Petersburg State Medical University, 6/8 L. Tolstoy Square, 197022, St. Petersburg, Russia. alekber@mail.ru
A A
AA
Bairamov
A O
AO
Poletaeva
S N
SN
Proshin
O M
OM
Efremov
N S
NS
Sapronov
D000818:Animals; D001535:Benactyzine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D001565:Benzoates / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D005865:Gestational Age; D008032:Limbic System / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010276:Parasympatholytics / Q000009:adverse effects* / Q000494:pharmacology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D001565:Benzoates; D010276:Parasympatholytics; D013739:Testosterone; C008380:metamizil; D001535:Benactyzine; C007824:ganglerone