Preparation and characterization of quantum dots coated magnetic hollow spheres for magnetic fluorescent multimodal imaging and drug delivery.
Innovative nanocomposites of magnetic and fluorescent multifunctional hollow spheres were developed, which combined magnetic resonance imaging (MRI), magnetic targeting, fluorescent imaging (FI) and drug delivery into one system. Fe3O4 hollow spheres were used as templates for the deposition of polyelectrolyte (PE) multilayers and CdTe quantum dots (QDs) via layer-by-layer (LBL) method. The PE multilayers/QDs coated Fe3O4 hollow spheres showed high magnetization and fluorescence, which can be used as magnetic and fluorescent multimodal imaging agent in vivo. The multifunctional nanomaterials of polyelectrolyte multilayers/QDs coated Fe3O4 hollow spheres were used as controlled drug release system, which showed pH-sensitive drug release over a long time. By combining the multiplexing imaging capability, the magnetic and fluorescent nanocomposites are potential candidates for simultaneous disease diagnosis and therapy.
Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Linlin
L
Li
Hongbo
H
Li
Dong
D
Chen
Huiyu
H
Liu
Fangqiong
F
Tang
Yanqi
Y
Zhang
Jun
J
Ren
Yi
Y
Li
D019187:Cadmium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D005453:Fluorescence; D008280:Magnetics; D053761:Nanocomposites / Q000737:chemistry*; D054118:Nanospheres / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D045663:Quantum Dots; D013691:Tellurium / Q000737:chemistry
D019187:Cadmium Compounds; D005290:Ferric Compounds; C000499:ferric oxide; D013691:Tellurium; C028337:cadmium telluride