[Predictive value of interleukin 6 from the umbilical cord blood in early neonatal infection].
We have analyzed diagnostic value of interleukin 6 (IL-6) from the umbilical cord blood in recognition of early neonatal infection (ENI) of newborns whose mothers have obstetrical risks. The study included 120 newborns with birth weight <2500 gr., gestational age from 37 to 42 weeks, which mothers had some of the obstetrical risks. We established three groups: group A (newborns with microbiological proof of ENI), group B (clinical signs and hematological parameters of ENI) and group C (newborns without ENI). Median of IL-6 value in group A was 48.5 pg/ml with sensitivity, specificity and diagnostic value in recognition of ENI 78%, 81% and 80%. In group B median of IL-6 was 49 pg/ml with sensitivity, specificity and diagnostic value 65%, 80% and 77%. In group C median of IL-6 was 9.7 pg/ml. We noticed significant connection between value of IL-6 and mother's urinary tract infection; group A (p=0.023), group B (p = 0.007). Also there was a remarkable relationship between mother's colpitis and level of IL-6 in newborn with ENI in group A (p=0.011) and group B (p = 0.012). High levels of IL-6 in umbilical cord blood can help us in recognition of newborns that are endangered by infection and they are clearly connected with some of mother's obstetrical risks.
Klinika za djecije bolesti, Univerzitetski klinicki centar Tuzla, BiH. almira_cosickic@yahoo.com
Almira
A
Cosićkić
Fahrija
F
Skokić
D015415:Biomarkers / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000175:diagnosis*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012307:Risk Factors; D012680:Sensitivity and Specificity
D015415:Biomarkers; D015850:Interleukin-6