Depressive symptoms and cervical neoplasia in HIV+ low-income minority women with human papillomavirus infection.
BACKGROUND
Prior work has related elevated life stress to greater risk of cervical neoplasia in women with human immunodeficiency virus (HIV) and human papillomavirus (HPV).


OBJECTIVE
This study investigated associations between depressive symptoms and cervical neoplasia in HIV+ HPV+ women. Participants were 58 HIV+ HPV+ women.


METHODS
Participants underwent colposcopy, including HPV screening, Papanicolaou smear, and cervical biopsy to determine study eligibility. Eligible participants completed the Beck Depression Inventory (BDI) and the Center for Epidemiologic Studies-Depression (CES-D) scale.


RESULTS
Presence and severity of clinically significant depressive symptomatology were associated with cervical neoplasia. Hierarchical logistic regression analysis revealed that women with greater depressive symptoms had marginally greater odds of presenting with cervical neoplasia (BDI: OR = 1.16, p = 0.092; CES-D: OR = 1.15, p = 0.067. Women with greater somatic depressive symptoms, specifically, had significantly greater odds of presenting with cervical neoplasia (BDI: OR = 1.86, p = 0.027; CES-D: OR = 1.56, p = 0.017).


CONCLUSIONS
These findings suggest that screening HIV+ women for somatic depression may help identify those at risk for cervical neoplasia. Future depression research with medical populations should discern somatic depressive symptoms from disease symptoms, as they may have important value in independently predicting health outcomes.
Dodd
Stacy M
SM
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610-0165, USA.
Pereira
Deidre B
DB
Marion
Ilona
I
Andrasik
Michele
M
Rose
Rachel
R
Simon
Trudi
T
Fletcher
Mary Ann
MA
Lucci
Joseph
J
Maher
Kevin
K
O'Sullivan
Mary Jo
MJ
Efantis-Potter
JoNell
J
Antoni
Michael H
MH
D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D052685:Alphapapillomavirus; D003866:Depressive Disorder / Q000453:epidemiology* / Q000523:psychology / Q000821:virology*; D005006:Ethnicity / Q000523:psychology / Q000706:statistics & numerical data; D005260:Female; D015658:HIV Infections / Q000523:psychology*; D006801:Humans; D007406:Interview, Psychological; D016015:Logistic Models; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000523:psychology*; D011203:Poverty; D012307:Risk Factors; D015144:Southeastern United States / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000523:psychology*; D055815:Young Adult