New penicillin susceptibility breakpoints for Streptococcus pneumoniae and their effects on susceptibility categorisation in Germany (1992-2008).
Continuous nationwide surveillance of invasive pneumococcal disease (IPD) has been conducted in Germany. From 1992 to 2008, 12137IPD isolates were collected, including 2201 isolates (18.1%) from patients with meningitis and 9936 isolates (81.9%) from non-meningitis cases. Data on penicillin susceptibility were available for 11814 invasive isolates. Categorisation of penicillin susceptibility according to the former Clinical and Laboratory Standards Institute (CLSI) guidelines resulted in 4.3% intermediate and 1.2% resistant isolates. When the new CLSI 2008 guidelines are applied, considerably higher resistance rates are observed in the meningitis group (6.5% resistant) than among the non-meningitis cases (0.0% resistant, 0.3% intermediate).
Imöhl
Matthias
M
Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital (RWTH), Pauwelsstr. 30, Aachen, Germany. mimoehl@ukaachen.de
Reinert
Ralf René
RR
van der Linden
Mark
M
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D024881:Drug Resistance, Bacterial; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000008:administration & dosage*; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D011159:Population Surveillance; D017410:Practice Guidelines as Topic; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D010406:Penicillins