[Experimental study of cardioprotective and endothelioprotective action of macrolides and azalides].
The cardioprotective and endothelioprotective effects of the macrolide antibiotics roxithromycin, azythromycin, and midecamycin have been studied on laboratory animals with models of the coronaro-occlusional myocardial infarction and endothelial dysfunction. The drugs led to a dose-dependent decrease in lethality, reduced the zone of necrosis of the left ventricle after coronary occlusion, and produced a positive effect on the functioning of endothelium.
Chernomortseva
E S
ES
Pokrovskiĭ
M V
MV
Pokrovskaia
T G
TG
Artiushkova
E B
EB
Gureev
V V
VV
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D054059:Coronary Occlusion / Q000150:complications; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D007933:Leucomycins / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D015575:Roxithromycin / Q000627:therapeutic use*; D016277:Ventricular Function, Left / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002316:Cardiotonic Agents; D007933:Leucomycins; D015575:Roxithromycin; D017963:Azithromycin; C026483:midecamycin