Association of GNB4 intron-1 haplotypes with survival in patients with UICC stage III and IV colorectal carcinoma.
BACKGROUND
Polymorphisms in genes encoding subunits of heterotrimeric G proteins have been repeatedly associated with the course of cancer. As previously shown, intron 1 of GNB4 harbours distinct haplotype blocks and block 1 is associated with survival and disease progression in urothelial bladder cancer. This study investigated whether haplotype block 2 is associated with survival in colorectal cancer patients.


METHODS
The haplotype tagging polymorphism of GNB4 haplotype block 2 was genotyped in 136 colorectal cancer patients and associated with demographic and clinical data and survival.


RESULTS
Haplotype block 2 is associated with survival in colorectal cancer patients. Patients with advanced tumour stages carrying the 2*1 haplotype revealed decreased survival (HR 2.04, 95% CI 0.91-3.69). In multivariate analysis, the diplotypes were independent prognostic factors.


CONCLUSIONS
Intron-1 haplotypes of GNB4 might be predictive markers for survival of patients with advanced colorectal cancer, thus influencing the clinical management of these patients.
Riemann
Kathrin
K
University Hospital Essen, Hufelandstr. 55, 45147 Essen, Germany. kathrin.riemann@uk-essen.de
Struwe
Henrike
H
Alakus
Hakan
H
Obermaier
Brigitte
B
Schmitz
Klaus J
KJ
Schmid
Kurt W
KW
Siffert
Winfried
W
D000368:Aged; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D005260:Female; D044387:GTP-Binding Protein beta Subunits / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics*; D008297:Male; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D015996:Survival Rate
C534984:GNB4 protein, human; D044387:GTP-Binding Protein beta Subunits