Radioprotection.
Over 40% of cancer patients will require radiation therapy during management of their disease. Although radiation therapy improves the survival of a significant number of cancer patients, both acute radiation toxicity (which manifests during a course of clinical radiotherapy or shortly thereafter), and late toxicity (developing months to years after completion of radiotherapy) compromise overall outcomes for successfully treated cancer patients.
Department of Radiation Oncology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA. greenbergerjs@upmc.edu
Joel S
JS
Greenberger
D004249:DNA Damage; D015195:Drug Design; D006801:Humans; D008928:Mitochondria / Q000528:radiation effects; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000188:drug therapy* / Q000517:prevention & control*; D011839:Radiation, Ionizing; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D017382:Reactive Oxygen Species; D016896:Treatment Outcome
D017382:Reactive Oxygen Species