Prenylflavonols from the leaves of Macaranga sampsonii.
Four novel prenylflavonols, macaranones A-D (1-4), were isolated from the leaves of Macaranga sampsonii. Their structures were elucidated on the basis of spectroscopic data. Macaranones C (3) and D (4) represent first two examples of flavonols having an unusual peltogynoid skeleton which is formed from a 2'-geranylflavonol by cyclization between 3-OH and C-1'' of the 2'-geranyl substituent of the flavonol. Compounds 1-4 were evaluated for the cytotoxicity against several human cancer cell lines.
Key Labotatory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.
Xiaohua
X
Li
Liangxiong
L
Xu
Ping
P
Wu
Haihui
H
Xie
Zhongliang
Z
Huang
Wanhui
W
Ye
Xiaoyi
X
Wei
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D019665:Euphorbiaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000633:toxicity; D044948:Flavonols / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry*; D054876:Prenylation
D000970:Antineoplastic Agents; D005419:Flavonoids; D044948:Flavonols; D010936:Plant Extracts; C540604:macaranone A; C540606:macaranone B; C540605:macaranone C; C540607:macaranone D