DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study.
BACKGROUND
Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia.


METHODS
In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples.


RESULTS
One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences.


CONCLUSIONS
The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships.
HUBIN Project, Department of Clinical Neuroscience, Karolinska Institutet and Hospital, Stockholm, Sweden. erik.jonsson@ki.se
Erik G
EG
Jönsson
Peter
P
Saetre
Maria
M
Vares
Dimitrios
D
Andreou
Kristina
K
Larsson
Sally
S
Timm
Henrik B
HB
Rasmussen
Srdjan
S
Djurovic
Ingrid
I
Melle
Ole A
OA
Andreassen
Ingrid
I
Agartz
Thomas
T
Werge
Håkan
H
Hall
Lars
L
Terenius
D000328:Adult; D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D003605:D-Amino-Acid Oxidase / Q000235:genetics*; D004252:DNA Mutational Analysis; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020890:Neuregulin-1; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D002352:Carrier Proteins; C475071:DAOA protein, human; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D047908:Intracellular Signaling Peptides and Proteins; C094131:NRG1 protein, human; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1; D018094:Receptors, Metabotropic Glutamate; C102718:metabotropic glutamate receptor 3; C417983:DAO protein, human; D003605:D-Amino-Acid Oxidase