Evidence of effectiveness from a large county-wide school-based influenza immunization campaign.
A school-based campaign in Knox County, TN immunized 41% and 48% of school children with live attenuated influenza vaccine in 2005 and 2006, respectively. We computed the relative risk (RR) of a positive rapid influenza test in Knox compared to Knox-surrounding county children (controls) during five baseline and two campaign seasons. Among children aged <5 years, the RR for a positive test remained relatively constant throughout the study seasons. Among children aged 5-17 years (target population), the RR was 1 during baseline and declined by 21% (RR, 0.79; 95% CI, 0.59-1.05) and 27% (RR, 0.73; 95% CI, 0.60-0.87) during the first and second campaign season, respectively. These findings suggest a direct beneficial effect of the immunization campaign.
Grijalva
Carlos G
CG
Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Avenue Suite 2600, The Village at Vanderbilt, Nashville, TN 37232-2637, United States. carlos.grijalva@vanderbilt.edu
Zhu
Yuwei
Y
Griffin
Marie R
MR
D000293:Adolescent; D000956:Antigens, Viral / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control*; D009975:Orthomyxoviridae / Q000302:isolation & purification; D012574:Schools; D013334:Students; D013714:Tennessee / Q000453:epidemiology; D014613:Vaccines, Attenuated / Q000276:immunology; D055815:Young Adult
D000956:Antigens, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated