[Metabolic syndrome and hormonal interaction in obese and type 2 diabetic Algerian subject: the behavior eating disorder impact].
BACKGROUND
These twenty last years, the metabolic syndrome was accused in various human pathologies including android obesity and type 2 diabetes. In obesity, increased body weight is frequently associated with excessive caloric food and sedentary activities. The Behaviour Eating Disorders (BED) is involved in over-consumption alimentary. In Algeria, we observed increasingly deviations in life-style alimentary, from the Mediterranean-Cretan model to American fast-food model.


OBJECTIVE
To study interactions between the BED, hormonal secretions and metabolic syndrome parameters.


METHODS
The present study was undertaken on Algerian population cohorts composed of 30 obese subjects, 70 type 2 diabetic patients and 30 healthy subjects. The BED was evaluated by TFEQ and DEBQ tests. Anthropometric parameters (waist circumference, IMC), metabolic parameters (glucose, triglycerides, HDL-C, LDL-C) and hormones (insulin, peptide C, ACTH, cortisol, GH) were determinates by biometrics, spectrophotometry and radioimmunology methods, respectively.


RESULTS
Multivariate analyses showed the high correlation between the BED and the metabolic syndrome, particularly a critical insulinoresistance state (IR). This IR generates in periphery a whole of metabolic disorders: dyslipidemia, hyperglycemia and hypertrophy of adipose tissue. In diabetic and obese patients, cortisol, ACTH and GH secretions are insidiously altered and to lead metabolic disorders.


CONCLUSIONS
In this study, the role of the BED in obesity and diabetes genesis seems to be confirmed. In response to nutritional stress, the BED generates a hyperactivity of endocrine pancreas, adrenal gland, and pituitary gland. It appeared that Algerian population is not adapted to fast-food American model.
Koceïr
E A
EA
Equipe de bioénergétique et métabolisme intermédiaire, Laboratoire de biologie et physiologie des organismes, Faculté des sciences biologiques, Université des Sciences et de la Technologie Houari Boumediene, Alger, Algérie. koceir@yahoo.fr
Benbaïbeche
H
H
Haffaf
El M
el M
Kacimi
G
G
Oudjit
B
B
D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D000462:Algeria; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D005247:Feeding Behavior / Q000502:physiology*; D001068:Feeding and Eating Disorders / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D005260:Female; D019270:Fructosamine / Q000097:blood; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000503:physiopathology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D010455:Peptides / Q000097:blood; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
D001786:Blood Glucose; D010455:Peptides; D014280:Triglycerides; C050632:polypeptide C; D019382:Human Growth Hormone; D019270:Fructosamine; D002784:Cholesterol