[Energetic changes in heart cells of white rats in stress conditions induced by violated diurnal cycle].
The aim of the study was to investigate the content and dynamics of nitric oxide (NO) and enzymes involved in generation and preservation of energy in cardiomyocytes under chronic stress condition, induced by circadian rhythm disturbances and isolation. For the present investigation white rats were selected as the experimental animal model. Quantitative decline in NO and decrease in enzyme activity (creatine/creatinphosphokinase/phosphocreatine and succinatedehydrogenase) under 30-day stress was found. Enzyme activity in white rat cardiomyocytes declined, and NO as a signal molecule increased. In accordance with experimental data it is supposed that the lack of ATP in cardiomyocytes is the main cause of various heart disorders.
Karapetian
M S
MS
Samkharadze
T N
TN
Dachanidze
N T
NT
Menabde
K O
KO
Koshoridze
N I
NI
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002940:Circadian Rhythm; D003402:Creatine Kinase / Q000378:metabolism; D004734:Energy Metabolism; D032383:Myocytes, Cardiac / Q000201:enzymology / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological
D009569:Nitric Oxide; D000255:Adenosine Triphosphate; D003402:Creatine Kinase