Further studies on the chemical constituents of Chinese folk medicine Gentiana apiata N.E. Br.
One new secoiridoid glycoside with conjugated diene, named 3-epi-swertiajaposide C (1), was isolated from the whole plants of Gentiana apiata N.E. Br., together with 11 known compounds, 7-deoxyloganic acid (2), isoorientin (3), gentiopicroside (4), silybin B (5), swertiamarin (6), asystasioside A (7), 6'-O-beta-D-glucopyranosylgentiopicroside (8), umbelliferone (9), oleanolic acid (10), kaempferol (11), and beta-sitosterol (12). The structure of the new compound (1) was elucidated on the basis of spectroscopic evidence including UV, IR, MS, NMR, HMBC, HMQC, and NOESY. Compounds 1, 2, 5, 6, 8, 9, and 11 were found in this plant for the first time. Moreover, silybin B (5) was isolated from the other plants besides Silybum marianum (L.) Gaertn for the first time by the present study.
Zhou
Le
L
College of Science, Northwest A&F University, Shaanxi, Yangling, China. zhoulechem@yahoo.com.cn
Li
Xing-Ke
XK
Miao
Fang
F
Yang
Ming-Li
ML
Yang
Xin-Juan
XJ
Sun
Wei
W
Yang
Jian
J
D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D030012:Gentiana / Q000737:chemistry*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008519:Medicine, Traditional; D015394:Molecular Structure
C432876:7-deoxyloganic acid; D004365:Drugs, Chinese Herbal; D039823:Iridoids