Kinetically locked luminescent metallomacrocycles as duplex DNA binding substrates.
A self-assembled, kinetically locked, tetranuclear metallomacrocycle interacts with duplex DNA with an affinity that is several orders of magnitude higher than its mononuclear building blocks, producing large-scale bending of the duplex structure.
Ghosh
Dipesh
D
Department of Chemistry, University of Sheffield, Sheffield, UK.
Ahmad
Haslina
H
A Thomas
Jim
J
D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D049449:Luminescence; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000378:metabolism*; D008670:Metals / Q000737:chemistry / Q000378:metabolism*; D009690:Nucleic Acid Conformation
D047028:Macrocyclic Compounds; D008670:Metals; D004247:DNA