Polyganglioradiculoneuritis in  a young cat: clinical and  histopathological findings.
An 18-month-old European shorthair cat was presented with a two week history of progressive decrease in consciousness, ambulatory tetraparesis, moderate ataxia and generalised decreased-to-absent postural reactions. Bilateral facial and nasal hypalgesia, absent menace response and anisocoria were found, and segmental spinal reflexes were normal. Neurological signs progressed to nonambulatory tetraparesis, tremor and spinal hyperalgesia. Histopathological examination revealed a mild-to-moderate lymphoplasmacytic and histiocytic infiltration, predominantly in the dorsal spinal roots, cranial nerves and ganglia in association with marked demyelination and proliferation of Schwann cells. Neurons and axons were preserved. Lesions were multi-focal and varied in severity. A predominantly sensory polyganglioradiculoneuritis was diagnosed. This lesion has not been reported previously in cats. Rabies, herpesviruses, feline infectious peritonitis, feline immunodeficiency virus, Toxoplasma gondii and feline leukaemia virus were excluded as possible aetiologies. Infections by other viruses or an autoimmune disease are discussed.
Department of Clinical Veterinary Medicine, Division of Clinical Neurology, Vetsuisse Faculty, University of Berne, Berne, Switzerland.
D
D
Henke
M
M
Vandevelde
A
A
Oevermann
D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000473:pathology; D002415:Cats; D003937:Diagnosis, Differential; D037901:Euthanasia, Animal; D017809:Fatal Outcome; D005260:Female; D007794:Lameness, Animal / Q000175:diagnosis; D011129:Polyradiculoneuropathy / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D012583:Schwann Cells / Q000473:pathology; D013126:Spinal Nerve Roots / Q000473:pathology