[Effect of antidepressant and psychological intervention on the quality of life and blood pressure in hypertensive patients with depression].
OBJECTIVE
To investigate the effect of antidepressant and psychological intervention on the blood pressure and quality of life in hypertensive patients with depression.


METHODS
After evaluating 950 patients with essential hypertension by Hospital Anxiety and Depression Scale (HAD), patients with HAD positive results were evaluated with Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA). The positive subjects with HAMD were randomly divided into an antidepressant and psychological intervention group (n=30, including routine treatment, mental state intervention, and antidepressant treatment) and a control group (n=30, routine treatment alone). The blood pressure, quality of life, and level of depression were compared between the 2 groups.


RESULTS
The depression symptoms were significantly improved in the antidepressant and psychological intervention group. The HAMD score fell from 30.03+/-1.83 at entrance to 17.43+/-1.96 at the end of study. The blood pressure control was more effective in the antidepressant and psychological intervention group than in the control group. The mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased by 26.17 mmHg and 13.63 mmHg in the antidepressant and psychological intervention group, while there were only 14.32 mmHg and 7.18 mmHg decrease in SBP and DBP respectively in the control group. Patients in the antidepressant and psychological intervention group had a higher score in the quality of life. The total score of GQOLI-74 increased from 65.97+/-4.68 before the treatment to 71.20+/-5.13 after the treatment.


CONCLUSIONS
Psychological intervention and antidepressant can improve the blood pressure control and quality of life in hypertensive patients with depression.
Department of Cardiology,Second Xiangya Hospital, Central South University, Changsha 410011, China. duanshu@medmail.com.cn
Shu
S
Duan
Jing
J
Xiao
Shuiping
S
Zhao
Xiongzhao
X
Zhu
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003863:Depression / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011613:Psychotherapy; D011788:Quality of Life
D000928:Antidepressive Agents