Cardioprotection by vanadium compounds targeting Akt-mediated signaling.
Treatment with inorganic and organic compounds of vanadium has been shown to exert a wide range of cardioprotective effects in myocardial ischemia/reperfusion-induced injury, myocardial hypertrophy, hypertension, and vascular diseases. Furthermore, administration of vanadium compounds improves cardiac performance and smooth muscle cell contractility and modulates blood pressure in various models of hypertension. Like other vanadium compounds, we documented bis(1-oxy-2-pyridinethiolato) oxovanadium (IV) [VO(OPT)] as a potent cardioprotective agent to elicit cardiac functional recovery in myocardial infarction and pressure overload-induced hypertrophy. Vanadium compounds activate Akt signaling through inhibition of protein tyrosine phosphatases, thereby eliciting cardioprotection in myocardial ischemia/reperfusion-induced injury and myocardial hypertrophy. Vanadium compounds also promote cardiac functional recovery by stimulation of glucose transport in diabetic heart. We here discuss the current understanding of mechanisms underlying vanadium compound-induced cardioprotection and propose a novel therapeutic strategy targeting for Akt signaling to rescue cardiomyocytes from heart failure.
Department of Pharmacology, Tohoku University, Japan.
M Shenuarin
MS
Bhuiyan
Kohji
K
Fukunaga
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D006332:Cardiomegaly / Q000473:pathology / Q000517:prevention & control; D002316:Cardiotonic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003925:Diabetic Angiopathies / Q000473:pathology / Q000517:prevention & control; D006331:Heart Diseases / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D032383:Myocytes, Cardiac / Q000187:drug effects; D051058:Oncogene Protein v-akt / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D017968:Vanadium Compounds / Q000009:adverse effects / Q000627:therapeutic use*
D002316:Cardiotonic Agents; D017968:Vanadium Compounds; D051058:Oncogene Protein v-akt