The changed immunoreactivity of StarD6 after pilocarpine-induced epilepsy.
This study was designed whether StarD6 is also affected by neurodegenerative stimuli, as other START proteins may be one of the delivery proteins in cholesterol metabolism of neurosteroid synthesis. Increased immunoreactivity of StarD6 was observed in all zones of the hippocampus by the administration of pilocarpine (350 mg/kg, intraperitoneally). More intense StarD6 immunolocalization was seen in the strata radiatum and lacunosum-moleculare, particularly in CA1-2 areas until 12 h after pilocarpine-induced epilepsy. StarD6 protein level was transiently increased at 3 h after pilocarpine-treated rat hippocampus comparing with normal rat. This raises the possibility that StarD6 might have nuclear roles and contribute to subsequent formation of neuroprotective steroids after excitotoxic brain injury.
Chang
In Youb
IY
Korean DNA Repair Research Center, College of Medicine, Chosun University, Gwangju, Republic of Korea.
Kim
Joong Kwon
JK
Lee
Seung Myung
SM
Kim
Jin Nam
JN
Soh
Jaemog
J
Kim
Jung Woo
JW
Yoon
Sang Pil
SP
D021581:Active Transport, Cell Nucleus / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003292:Convulsants / Q000494:pharmacology; D019610:Cytoprotection / Q000502:physiology*; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D007150:Immunohistochemistry; D008297:Male; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009498:Neurotoxins / Q000037:antagonists & inhibitors; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013256:Steroids / Q000096:biosynthesis*; D013997:Time Factors; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
D002352:Carrier Proteins; D003292:Convulsants; D009498:Neurotoxins; C523101:StarD6 protein, rat; D013256:Steroids; D010862:Pilocarpine; D002784:Cholesterol