Radioprotection.
Over 40% of cancer patients will require radiation therapy during management of their disease. Although radiation therapy improves the survival of a significant number of cancer patients, both acute radiation toxicity (which manifests during a course of clinical radiotherapy or shortly thereafter), and late toxicity (developing months to years after completion of radiotherapy) compromise overall outcomes for successfully treated cancer patients.
Greenberger
Joel S
JS
Department of Radiation Oncology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA. greenbergerjs@upmc.edu
D004249:DNA Damage; D015195:Drug Design; D006801:Humans; D008928:Mitochondria / Q000528:radiation effects; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000188:drug therapy* / Q000517:prevention & control*; D011839:Radiation, Ionizing; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D017382:Reactive Oxygen Species; D016896:Treatment Outcome
D017382:Reactive Oxygen Species