Ingol and ingenol diterpenes from the aerial parts of Euphorbia royleana and their antiangiogenic activities.
Ten new ingol lathyrane-type diterpenes (1-10) and two known ingenol derivatives (11 and 12) were isolated from the aerial parts of Euphorbia royleana. The structures of 1-10 were elucidated on the basis of spectroscopic methods including 2D NMR analysis, and the structure of compound 1 was confirmed by single-crystal X-ray crystallography. Antiangiogenic effects of all compounds except for 5 were tested using a zebrafish model, with compounds 11 and 12 being active in this bioassay.
Li
Xiao-Li
XL
Laboratory of Ethnobotany, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming Yunnan, People's Republic of China.
Li
Yang
Y
Wang
Si-Feng
SF
Zhao
Yan-Li
YL
Liu
Ke-Chun
KC
Wang
Xi-Min
XM
Yang
Yong-Ping
YP
D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D018360:Crystallography, X-Ray; D004195:Disease Models, Animal; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D015027:Zebrafish
D020533:Angiogenesis Inhibitors; D004224:Diterpenes; C530347:lathyrane; C008125:ingenol