Field-effect devices for detecting cellular signals.
The integration of living cells together with silicon field-effect devices challenges a new generation of biosensors and bioelectronic devices. Cells are representing highly organised complex systems, optimised by millions of years of evolution and offering a broad spectrum of bioanalytical receptor "tools" such as enzymes, nucleic acids proteins, etc. Their combination with semiconductor-based electronic chips allows the construction of functional hybrid systems with unique functional and electronic properties for both fundamental studies and biosensoric applications. This review article summarises recent advances and trends in research and development of cell/transistor hybrids (cell-based field-effect transistors) as well as light-addressable potentiometric sensors.
Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Campus Jülich, Ginsterweg 1, D-52428 Jülich, Germany.
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Poghossian
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Ingebrandt
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Offenhäusser
M J
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Schöning
D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D002448:Cell Adhesion; D002470:Cell Survival; D002477:Cells / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008027:Light; D011199:Potentiometry