Cycle-specific organocascade catalysis: application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis.
United in effort: The combined application of iminium (Im) and enamine (En) catalysts can effect a range of valuable asymmetric transformations including 1,2-hydroamination, -hydro-oxidation, and -amino-oxidation of olefins (see picture). An enantioselective organocascade catalysis was also applied in the synthesis of a complex natural product.
Merck Center for Catalysis at Princeton University, Washington Road, Princeton NJ 08544-1009, USA.
Bryon
B
Simmons
Abbas M
AM
Walji
David W C
DW
MacMillan
D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D010084:Oxidation-Reduction; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D045789:Sesquiterpenes, Guaiane; D013237:Stereoisomerism
D000475:Alkenes; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C543650:aromadendranediol