Transdermal methylphenidate system: old wine in a new bottle.
BACKGROUND
The methylphenidate transdermal system (MTS) is a novel formulation of methylphenidate, a psychostimulant, in an adhesive-based matrix transdermal system (patch) that is applied to intact skin. This is deliverable in a transdermal patch for the treatment of attention-deficit/hyperactivity disorders.


OBJECTIVE
This paper seeks to review the supporting data for the use of the MTS patch, including its efficacy, safety and other considerations in its use.


METHODS
Clinical studies using MTS are reviewed.


CONCLUSIONS
The MTS patch shows similar levels of efficacy and safety as other methylphenidate formulations and stimulants, although the time to onset of effects may be longer. The patch delivery system allows for flexibility in the duration of effect and reduced reliance on oral administration.
Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and clinic, School of Medicine, Pittsburgh, PA 15213, USA. buksteinog@upmc.edu
Oscar G
OG
Bukstein
D000279:Administration, Cutaneous; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006801:Humans; D008774:Methylphenidate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D013997:Time Factors
D000697:Central Nervous System Stimulants; D003692:Delayed-Action Preparations; D008774:Methylphenidate