Targeted endoscopic imaging.
Endoscopy has undergone explosive technological growth in recent years, and with the emergence of targeted imaging, its truly transformative power and impact on medicine lies just over the horizon. Today, our ability to see inside the digestive tract with medical endoscopy is headed toward exciting crossroads. The existing paradigm of making diagnostic decisions based on observing structural changes and identifying anatomic landmarks may soon be replaced by visualizing functional properties and imaging molecular expression. In this novel approach, the presence of intracellular and cell surface targets unique to disease are identified and used to predict the likelihood of mucosal transformation and response to therapy. This strategy could result in the development of new methods for early cancer detection, personalized therapy, and chemoprevention. This targeted approach will require further development of molecular probes and endoscopic instruments, and will need support from the US Food and Drug Administration for streamlined regulatory oversight. Overall, this molecular imaging modality promises to significantly broaden the capabilities of the gastroenterologist by providing a new approach to visualize the mucosa of the digestive tract in a manner that has never been seen before.
Department of Medicine, University of Michigan School of Medicine, Ann Arbor, 48109, USA.
Meng
M
Li
Thomas D
TD
Wang
D002471:Cell Transformation, Neoplastic; D016099:Endoscopy, Gastrointestinal / Q000379:methods* / Q000592:standards / Q000639:trends; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000473:pathology; D025202:Molecular Diagnostic Techniques; D011230:Precancerous Conditions / Q000175:diagnosis / Q000235:genetics*; D012680:Sensitivity and Specificity