Ophiodilactones A and B, cytotoxic tetrameric phenylpropanoids, from the ophiuroid Ophiocoma scolopendrina.
Two tetrameric phenylpropanoids, ophiodilactones A (1) and B (2), were isolated from the ophiuroid Ophiocoma scolopendrina. Their structures were determined on the basis of spectroscopic data. Ophiodilactone B has a novel carbon skeleton. They exhibit moderate cytotoxic activity against P388 murine leukemia cells.
Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Reiko
R
Ueoka
Toshihiko
T
Fujita
Shigeki
S
Matsunaga
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001555:Benzene Derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007938:Leukemia / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D015394:Molecular Structure; D013057:Spectrum Analysis; D013215:Starfish
D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D007783:Lactones; C542751:ophiodilactone A; C542752:ophiodilactone B