New insights into target organ involvement in hypertension.
Hypertension and its sequelae are complex processes. Optimization of the care of the hypertensive patient requires not only attention to the regulation of arterial pressure but also attention to blunting the hypertension-related processes that lead to vascular disease. It is clear that the regulation of these processes is much more complex than previously understood. Here several new insights into the pathogenesis of hypertension-related vascular disease have been explored. While this review is not exhaustive, it does serve to point out the varied nature of the biologic processes that must be taken into account and it points to new avenues for the development of therapeutic agents.
Ochsner Clinic Foundation, New Orleans, LA 70121, USA. rre@ochsner.org
Richard N
RN
Re
D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D044140:Receptor, Angiotensin, Type 1 / Q000187:drug effects / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D015291:Transforming Growth Factors / Q000502:physiology; D014652:Vascular Diseases / Q000209:etiology / Q000503:physiopathology; D000093342:Prorenin Receptor
D044140:Receptor, Angiotensin, Type 1; D011956:Receptors, Cell Surface; D015291:Transforming Growth Factors; D000093342:Prorenin Receptor