Weight change and incident metabolic syndrome in Iranian men and women; a 3 year follow-up study.
BACKGROUND
Although the association of weight gain and developing metabolic syndrome (MetS) has been reported in the Western and Asian populations, data on the gender-stratified effects of weight change (including weight loss) on incident MetS and its components in the Middle East Caucasians is still scarce.


METHODS
A total of 1431 men and 2036 women aged > OR years with BMI > 18.5 kg/m2 were followed over 3 years. Multivariate logistic regression analysis was used to estimate the relative risk (RR) of MetS and its components (the Adult Treatment Panel III definition) associated with gender-stratified quintiles of percent weight change. Subjects with MetS at baseline were excluded for analyzing the RR of MetS.


RESULTS
There was 20.4% (95% CI, 19.6-21.2) age-adjusted incident MetS (18.4% male vs. 23.1% women). In men, mild weight gain (WG) predicted high waist circumference (WC) and high triglyceride; moderate WG predicted MetS (RR 2.5, 95% CI 1.4-4.3), high WC and high blood pressure (BP); large WG predicted MetS (RR 3.2, 95% CI 1.8-5.7) and its components, except for high fasting plasma glucose. In women, mild WG predicted MetS (RR 2.5, 95% CI 1.4-4.3), high WC and high BP; moderate WG predicted Mets (RR 4.6, 95% CI 2.7-8.0), high WC and high triglyceride; large WG predicted MetS (RR 6.6, 95% CI 3.8-11.3) and its components except for low HDL-cholesterol. Mild weight loss had protective effect on high WC in both genders and MetS in men (RR 0.5, 95% CI 0.26-0.97, P = 0.04).


CONCLUSIONS
Weight change showed different effects on MetS in men and women. In women, mild WG predicted MetS; however, mild weight loss was protective against MetS in men and high WC in both genders.
Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. zabetian@endocrine.ac.ir
Azadeh
A
Zabetian
Farzad
F
Hadaegh
Parvin
P
Sarbakhsh
Fereidoun
F
Azizi
D000328:Adult; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D015438:Health Behavior; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D012307:Risk Factors; D015430:Weight Gain; D015431:Weight Loss