Stimuli-responsive controlled drug release from magnetic-sensitive silica nanospheres.
A novel method for control burst releasing of drug via a high frequency magnetic field (HFMF) from magnetic-sensitive silica nanospheres was developed. The nanospheres were synthesized by a combination of emulsion and sol-gel process with the particles controlled at about 80 nm in diameter. Under repeated exposures to the high frequency magnetic stimulus, the drug release behaviors showed reproducible slow-to-burst profiles while consecutively applying the magnetic stimulus at 10-min switching time and the release profile restored immediately when the stimulus was removed. By taking this non-contact control-burst method, the magnetic silica nanospheres can be designed to treat the cancer therapy and urgent physiological needs.
Department of Materials Sciences and Engineering, National Chiao Tung University, Hsinchu, Taiwan, 300, China.
Shang-Hsiu
SH
Hu
Ting-Yu
TY
Liu
Hsin-Yang
HY
Huang
Dean-Mo
DM
Liu
San-Yuan
SY
Chen
D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D054118:Nanospheres; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012822:Silicon Dioxide
D004364:Pharmaceutical Preparations; D012822:Silicon Dioxide