Immunohistochemical staining of mucin 1 in prostate tissues.
Prostate cancer is a major public health problem in the world. Molecular studies are necessary for the development of prognostic markers in prostate cancer. There is a great interest in mucin studies in treatment development of human malignancies, including prostate cancer. Nevertheless, their expressions in prostate cancer need further investigation.


METHODS
Mucin 1 (MUC1) expression was examined in 100 prostate biopsies and were compared with prostate carcinoma cell lines (DU-145, PC-3, LNCaP) by immunohistochemistry.


RESULTS
Biopsies were healthy, tumor, peritumor or presented an intraepithelial neoplasia. Staining of MUC1 was exihibited in PC-3 cells, was higher in DU-145, and was not expressed by LNCaP. Tumor sections presented more positive expression of MUC1 than non-tumor sections.


CONCLUSIONS
MUC1 expression is correlated with the histological degree of malignancy.
Département d'Oncogénétique du Centre Jean Perrin, Occupational Health Institute, CHU, 58 rue Montalembert, B.P.392, 63011 Clermont-Ferrand Cedex 01, France.
Nadege
N
Rabiau
Pierre
P
Dechelotte
Laurent
L
Guy
Samir
S
Satih
Remy
R
Bosviel
Luc
L
Fontana
Jean-Louis
JL
Kemeny
Jean-Paul
JP
Boiteux
Yves-Jean
YJ
Bignon
Dominique
D
Bernard-Gallon
D000230:Adenocarcinoma / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000096:biosynthesis; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001706:Biopsy; D045744:Cell Line, Tumor; D003593:Cytoplasm / Q000378:metabolism; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008297:Male; D018396:Mucin-1 / Q000096:biosynthesis*; D011467:Prostate / Q000378:metabolism*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018396:Mucin-1