Decreased serum esRAGE level is associated with angiographically determined coronary plaque progression in diabetic patients.
OBJECTIVE
This study evaluated the relationship between serum levels of endogenous secretory receptor for advanced glycation endproducts (esRAGE) and coronary plaque progression in diabetic and nondiabetic patients.


METHODS
Serum esRAGE level was measured and quantitative coronary angiography (QCA) was performed in 265 consecutive patients at baseline and 1-year follow-up.


RESULTS
Comparing to baseline, serum esRAGE level was significantly increased during follow-up in nondiabetic patients without plaque progression (p=0.014), unchanged in nondiabetic patients with plaque progression and diabetic patients without plaque progression, and decreased in diabetic patients with plaque progression (p=0.011). Moreover, change of esRAGE levels correlated with change of QCA measurements. Multivariable regression analyses revealed that high-density lipoprotein cholesterol (OR=0.214, p=0.037), hypertension (OR=2.755, p=0.011), high-sensitivity C-reactive protein (OR=1.083, p<0.001) and change of esRAGE (OR=23.477, p<0.001) were independent risk factors for plaque progression in diabetic patients.


CONCLUSIONS
This study demonstrated an association of decreased serum esRAGE level with coronary plaque progression in patients with diabetes.
Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, People's Republic of China.
Wen Hui
WH
Peng
Lin
L
Lu
Jian
J
Hu
Xiao Xiang
XX
Yan
Qi
Q
Zhang
Rui Yan
RY
Zhang
Qiu Jin
QJ
Chen
Wei Feng
WF
Shen
D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D017023:Coronary Angiography; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications; D018450:Disease Progression; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D012044:Regression Analysis
D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D002097:C-Reactive Protein