Self-termination/anergic mechanisms in human basophils and mast cells.
All cellular reactions include feedback loops, both positive and negative. Following all receptor-mediated stimulation there are events that activate the cell response and events that dampen the receptor response back to resting conditions. IgE-mediated activation of mast cells and basophils necessarily includes a variety of signaling events that serve to terminate the activation processes. Some of these negative feedback loops are active even in resting cells and likely serve to establish a set point for the cell's response to IgE-mediated stimulation. But many negative feedback loops become active only after the cell is stimulated. By and large, it will be these processes that will be discussed in this review.
MacGlashan
Donald W
DW
Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224, USA. dmacglas@jhmi.edu
D000818:Animals; D001491:Basophils / Q000276:immunology* / Q000378:metabolism; D015550:Cell Degranulation / Q000276:immunology; D017635:Clonal Anergy / Q000276:immunology*; D015536:Down-Regulation / Q000276:immunology; D025461:Feedback, Physiological / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology
D007073:Immunoglobulin E