Signaling pathways regulating zebrafish lateral line development.
The lateral line organ is a mechanosensory organ of fish and amphibians that detects changes in water flow. The lateral line organ of zebrafish has been used as a model for cell polarity and collective cell migration as well as hair cell loss and regeneration. A combination of genetic tools and live imaging has allowed dissection of signaling pathways that regulate these processes. Here, we summarize recent findings on the roles of the FGF, Wnt/beta-catenin, and Notch pathways in the initial formation of the posterior lateral line primordium, as well as during organ patterning, migration, cell fate specification and hair cell regeneration.
Ma
Eva Y
EY
University of Washington, Box 357420, Seattle, WA 98195-7420, USA.
Raible
David W
DW
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D005346:Fibroblast Growth Factors / Q000378:metabolism; D053403:Lateral Line System / Q000196:embryology* / Q000378:metabolism*; D009024:Morphogenesis / Q000502:physiology*; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology*; D051176:beta Catenin / Q000378:metabolism
D051880:Receptors, Notch; D051153:Wnt Proteins; D051176:beta Catenin; D005346:Fibroblast Growth Factors