[Some aspects of metabolic dysregulation in patients with ischemic stroke].
To study the mechanisms of formation of an endogenous intoxication syndrome in patients after ischemic stroke, the activity of platelet monoaminooxidase (MAO) and serum aminooxidase, concentration of middle-size molecules and parameters of functional albumin activity have been determined in 27 patients with illness duration 4-5 months and 16 healthy age- and sex-matched controls. The significant dysregulation of biogenic amine metabolism and total homeostasis was observed in patients compared to controls. There were a significant increase of MAO and concentration of middle-size molecules and a decrease of aminooxidase and functional albumin activity (p < 0.01). Such metabolic disturbances suggest a presence of endogenous intoxication. A possible mechanism of formation of an endogenous intoxication syndrome in ischemic stroke is discussed.
Shklovskiĭ
V M
VM
Alferova
V V
VV
Uzbekov
M G
MG
Misionzhhik
E Iu
EIu
Luk'ianiuk
E V
EV
Shikhov
S N
SN
D000328:Adult; D000368:Aged; D000418:Albumins / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D011379:Prognosis; D012720:Severity of Illness Index
D000418:Albumins; D008995:Monoamine Oxidase