Three-dimensional biodegradable structures fabricated by two-photon polymerization.
Two-photon polymerization has been employed to fabricate three-dimensional structures using the biodegradable triblock copolymer poly(epsilon-caprolactone-co-trimethylenecarbonate)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone-co-trimethylenecarbonate) with 4,4'-bis(diethylamino)benzophenone as the photoinitiator. The fabricated structures were of good quality and had four micron resolution. Initial cytotoxicity tests show that the material does not affect cell proliferation. These studies demonstrate the potential of two-photon polymerization as a technology for the fabrication of biodegradable scaffolds for tissue engineering.
Engineering Materials Department, Biomaterials and Tissue Engineering Group, Kroto Research Institute, University of Sheffield, Broad Lane, Sheffield S3 7HQ, United Kingdom. f.claeyssens@sheffield.ac.uk
Frederik
F
Claeyssens
Erol A
EA
Hasan
Arune
A
Gaidukeviciute
Demetra S
DS
Achilleos
Anthi
A
Ranella
Carsten
C
Reinhardt
Aleksandr
A
Ovsianikov
Xiao
X
Shizhou
Costas
C
Fotakis
Maria
M
Vamvakaki
Boris N
BN
Chichkov
Maria
M
Farsari
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001673:Biodegradation, Environmental; D049109:Cell Proliferation; D004867:Equipment Design; D008027:Light; D051379:Mice; D008807:Mice, Inbred BALB C; D008956:Models, Chemical; D041681:NIH 3T3 Cells; D010777:Photochemistry / Q000379:methods; D017785:Photons; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods
D001672:Biocompatible Materials; D011108:Polymers