Coronaviruses post-SARS: update on replication and pathogenesis.
Although coronaviruses were first identified nearly 60 years ago, they only received notoriety in 2003 when one of their members was identified as the aetiological agent of severe acute respiratory syndrome. Previously these viruses were known to be important agents of respiratory and enteric infections of domestic and companion animals and to cause approximately 15% of all cases of the common cold. This Review focuses on recent advances in our understanding of the mechanisms of coronavirus replication, interactions with the host immune response and disease pathogenesis. It also highlights the recent identification of numerous novel coronaviruses and the propensity of this virus family to cross species barriers.
Department of Microbiology and Interdisciplinary Program in Immunology, University of Iowa, Iowa City, 52242, USA. stanley-perlman@uiowa.edu
Stanley
S
Perlman
Jason
J
Netland
D000818:Animals; D017934:Coronavirus / Q000276:immunology* / Q000472:pathogenicity*; D018352:Coronavirus Infections / Q000276:immunology / Q000821:virology*; D006801:Humans; D008954:Models, Biological; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology / Q000821:virology*; D014779:Virus Replication / Q000502:physiology*