[Evaluation of C-reactive protein levels in serum and gingival crevicular fluid in type 2 diabetes patients with periodontitis].
OBJECTIVE
To observe the relationship of the C-reactive protein (CRP) levels and the severity of the periodontal inflammation and the diabetes glycemic control.


METHODS
The CRP levels in serum and in gingival crevicular fluid(GCF) in type 2 diabetes patients with chronic periodontitis, patients with periodontitis alone, patients with type 2 diabetes alone and healthy people were assayed. Glycosylated hemoglobin (HbAlc) in serum was detected. Probing depth (PD) and sulcus bleeding index (SBI) were recorded. The data were analyzed by non-paired t test and Spearman correlation analysis with SPSS 10.0 software package.


RESULTS
The serum CRP levels in type 2 diabetes patients with periodontitis and periodontitis and type 2 diabetes were significantly higher than those in healthy group(P<0.01). Serum CRP levels in type 2 diabetes patients with periodontitis were the highest and were significantly higher than that in periodontitis group(P<0.01) and type 2 diabetes group(P<0.05). However, the CRP levels in GCF in each group were far lower than those in serum and no difference was detected in the four groups (P>0.05). The CRP levels in serum didn't correlate to the CRP levels in GCF (P>0.05).The CRP levels in serum correlated to PD, SBI and HbAlc(P<0.01).


CONCLUSIONS
CRP may be involved in the interaction of chronic periodontitis and type 2 diabetes. The CRP levels in GCF could not reflect the inflammation of the periodontitis or the condition of diabetes.
Wu
Chun-Lan
CL
Department of Stomatology, Third People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China. wuchunlan9229@163.com
Chen
Feng-Ling
FL
D002097:C-Reactive Protein; D055113:Chronic Periodontitis; D003924:Diabetes Mellitus, Type 2; D005883:Gingival Crevicular Fluid; D006801:Humans; D010518:Periodontitis
D002097:C-Reactive Protein