[Using NO-synthase inhibitors derived from L-arginine for preventing acute experimental lung edema development in mice].
The preventive and curative action of NO-synthase inhibitors derived from L-arginine was investigated on the model of toxic lung edema induced by phosgene (LCt50 - 84) in mice. The most pronounced decrease in the phosgene-induced lung edema was observed for aminoguanidine, NG-nitro-L-arginine (L-NNA), and L-nitroarginine methyl ester (L-NAME). Aminoguanidine was effective in cases of both preventive and curative administration. L-NNA, an inhibitor of the constitutive isoform of NO-synthase, was effective only after preventive injection, while L-NAME, an inhibitor of both inducible and constitutive isoforms of NO-synthase, was effective only after curative use. Therefore, the NO-synthase inhibitors are a promising group of pharmacological agents for the treatment of toxic lung edema induced by phosgene.
Torkunov
P A
PA
Shabanov
P D
PD
D000208:Acute Disease; D000818:Animals; D006146:Guanidines / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology* / Q000627:therapeutic use; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I / Q000037:antagonists & inhibitors; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D052250:Nitric Oxide Synthase Type III / Q000037:antagonists & inhibitors; D019335:Nitroarginine / Q000494:pharmacology* / Q000627:therapeutic use; D010705:Phosgene; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy*
D006146:Guanidines; D010705:Phosgene; D019335:Nitroarginine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; C004479:pimagedine; D019331:NG-Nitroarginine Methyl Ester