Perineuritis in acute lyme neuroborreliosis.
Perineuritis is an unusual cause of direct peripheral nerve injury. We describe the clinicopathologic features of a 56-year-old man with mononeuritis multiplex due to Lyme disease; sural nerve biopsy demonstrated florid perineuritis. Treatment with intravenous ceftriaxone resulted in marked neurologic improvement. This study supports the notion that perineuritis forms part of the pathogenesis in acute Lyme neuroborreliosis.
Department of Neurology, University College Hospital, Galway, Ireland.
Marwa
M
Elamin
Yazan
Y
Alderazi
Gerard
G
Mullins
Michael A
MA
Farrell
Sue
S
O'Connell
Timothy J
TJ
Counihan
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001132:Arm / Q000294:innervation / Q000503:physiopathology; D001369:Axons / Q000473:pathology; D001706:Biopsy; D002443:Ceftriaxone / Q000627:therapeutic use; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007866:Leg / Q000294:innervation / Q000503:physiopathology; D020852:Lyme Neuroborreliosis / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D018908:Muscle Weakness / Q000382:microbiology / Q000503:physiopathology; D009443:Neuritis / Q000382:microbiology* / Q000473:pathology* / Q000503:physiopathology; D010525:Peripheral Nerves / Q000276:immunology / Q000382:microbiology* / Q000473:pathology*; D013497:Sural Nerve / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome; D014855:Wallerian Degeneration / Q000276:immunology / Q000382:microbiology / Q000473:pathology
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D002443:Ceftriaxone; D008775:Methylprednisolone