Phenylphenalenones from the Australian plant Haemodorum simplex.
Chemical investigation of the Australian plant Haemodorum simplex resulted in the isolation of three new phenylphenalenones, haemodorone (10), haemodorol (11), and haemodorose (12), together with the previously reported compounds 5, dilatrin (6), and xiphidone (8). The first complete 2D NMR characterization for all of the compounds isolated, including several chemical shift reassignments for dilatrin (6), is reported. In addition this is one of the few reports to discuss the isolation of new phenylphenalenones from an Australian medicinal plant. The crude extract of both the bulbaceous and aerial components of the plant exhibited varying degrees of antibacterial, antifungal, and antiviral activity, and only the bulbs displayed potent cytotoxic activity.
School of Applied Sciences (Discipline of Applied Chemistry), RMIT University, Melbourne, Victoria, Australia.
Daniel Anthony
DA
Dias
David James
DJ
Goble
Claudio Andres
CA
Silva
Sylvia
S
Urban
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D043803:Phenalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D017955:Poliovirus / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D043803:Phenalenes; C541857:haemodorol; C541856:haemodorone; C541858:haemodorose