New frontiers in cell-based immunotherapy of cancer.
BACKGROUND
Cancer remains one of the leading causes of death. Over the past decade, discovery of tumor antigens, as well as new findings in basic immunology, have led to novel opportunities for developing active immunotherapeutical approaches for prevention and treatment of cancer.


OBJECTIVE
This is a review of the literature and patents on the therapeutic potential of immune-based cell cancer therapies.


CONCLUSIONS
In this article, we discuss the different approaches at present used for immune-based cell cancer therapies, and the results obtained both in preclinical models and in clinical trials of hematological malignancies and solid tumors.
University of Florence, Department of Internal Medicine, Florence, Italy.
Mario Milco
MM
D'Elios
Gianfranco
G
Del Prete
Amedeo
A
Amedei
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D010330:Patents as Topic
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines