Both AP-1 and NF-kappaB seem to be involved in tumour growth in an experimental rat hepatoma.
Daily treatment of rats bearing Yoshida AH-130 ascites hepatoma with the nuclear factor kappa-B (NF-kappaB) and activator protein-1 (AP-1) double inhibitors SP100030 and SP100207 at a dose of 5 mg/kg and 10 mg/kg of body weight, respectively, resulted in a clear inhibition of tumour growth. The decrease was not related to an altered cell cycle distribution of the tumour cell population suggesting a merely necrotic effect. The results presented confirm that both transcription factors are involved in the growth of the experimental tumour system used, suggesting that both signaling cascades play a very important role in the signaling of tumour cell proliferation. This could, in future, allow for the development of new therapeutic strategies for cancer patients.
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028-Barcelona, Spain.
Rodrigo
R
Moore-Carrasco
Sílvia
S
Busquets
Maite
M
Figueras
Moorthy
M
Palanki
Francisco J
FJ
López-Soriano
Josep M
JM
Argilés
D000818:Animals; D005434:Flow Cytometry; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008297:Male; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000502:physiology*; D009930:Organic Chemicals / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018808:Transcription Factor AP-1 / Q000037:antagonists & inhibitors / Q000502:physiology*; D000813:Anilides; D001549:Benzamides; D011743:Pyrimidines
D007166:Immunosuppressive Agents; D016328:NF-kappa B; D009930:Organic Chemicals; D018808:Transcription Factor AP-1; C102914:N-(3,5-bis(trifluoromethyl)phenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide; D000813:Anilides; D001549:Benzamides; D011743:Pyrimidines