The rat as an animal model of Alzheimer's disease.
As a disease model, the laboratory rat has contributed enormously to neuroscience research over the years. It has also been a popular animal model for Alzheimer's disease but its popularity has diminished during the last decade, as techniques for genetic manipulation in rats have lagged behind that of mice. In recent years, the rat has been making a comeback as an Alzheimer's disease model and the appearance of increasing numbers of transgenic rats will be a welcome and valuable complement to the existing mouse models. This review summarizes the contributions and current status of the rat as an animal model of Alzheimer's disease.
Benedikz
Eirikur
E
Karolinska Institutet, Department of Neurobiology, Novum, Stockholm, Sweden. eirikur.benedikz@ki.se <eirikur.benedikz@ki.se>
Kloskowska
Ewa
E
Winblad
Bengt
B
D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D006801:Humans; D051381:Rats
D016564:Amyloid beta-Protein Precursor