Peri-implant endosseous healing properties of dual acid-etched mini-implants with a nanometer-sized deposition of CaP: a histological and histomorphometric human study.
OBJECTIVE
The aim of this histological and histomorphometric study was to compare the early peri-implant endosseous healing properties of a dual acid-etched (DAE) surface (Osseotite, Implant Innovations Inc., Palm Beach Gardens, FL, USA) with a DAE surface modified with nanometer-sized calcium phosphate (CaP) particles (NanoTite, Implant Innovations Inc.) in grafted and mature maxillary bone.


METHODS
Fifteen patients received two mini-implants, 1 with DAE surface (control) and 1 with a DAE + CaP surface (test), to fixate an iliac crest bone graft to the maxilla. A part of each mini-implant was in contact with the grafted bone and a part extended into the native maxillary bone. After a healing period of 3 months, the specimens were harvested and analyzed.


RESULTS
Overall, a trend was seen for stronger bone response around the test mini-implants in the native bone of the maxilla. However, only the old bone particles measured by percentages of bone-to-implant contact and bone area were statistically significant (p = .025 and p = .042, respectively).


CONCLUSIONS
The NanoTite surface increases the peri-implant endosseous healing properties in the native bone of the maxilla compared with the Osseotite surface, while this difference was not visible in the bone graft area. This might be a result of the lower remodeling process of the graft.
Telleman
Gerdien
G
Department of Oral and Maxillofacial Surgery, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands. g.telleman@kchir.umcg.nl
Albrektsson
Tomas
T
Hoffman
Maria
M
Johansson
Carina B
CB
Vissink
Arjan
A
Meijer
Henny J A
HJ
Raghoebar
Gerry M
GM
D000134:Acid Etching, Dental; D000368:Aged; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D016025:Bone Transplantation / Q000295:instrumentation* / Q000502:physiology; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D017267:Dental Prosthesis Design; D005260:Female; D006801:Humans; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging / Q000601:surgery; D008875:Middle Aged; D008904:Miniaturization; D053758:Nanoparticles; D016348:Osseointegration; D011859:Radiography; D013499:Surface Properties; D014945:Wound Healing
D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; C020243:calcium phosphate