Effect of magnesium sulfate on the osmotic fragility and lipid peroxidation of intact red blood cells from pregnant women with severe preeclampsia.
OBJECTIVE
To evaluate the osmotic fragility and level of lipid peroxidation of red blood cells from pregnant women with severe preeclampsia, treated or not with MgSO(4).


METHODS
Osmotic fragility and lipid peroxidation of red blood cells was evaluated in 11 normotensive pregnant women and eleven pregnant women with severe preeclampsia.


RESULTS
MgSO(4) therapy, either in vivo or in vitro, leads to a reduction of the osmotic fragility and the level of lipid peroxidation of red blood cells from pregnant women with severe preeclampsia.


CONCLUSIONS
Interaction of MgSO(4) with free radicals, by avoiding an excessive lipid peroxidation of the red blood cell membrane, would protect the membrane structure, avoiding in this way the increase in osmotic fragility.
Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
Cilia
C
Abad
María J
MJ
Carrasco
Sandy
S
Piñero
Eri
E
Delgado
Delia Indira
DI
Chiarello
Alejandro
A
Teppa-Garrán
Teresa
T
Proverbio
Fulgencio
F
Proverbio
Reinaldo
R
Marín
D000328:Adult; D000704:Analysis of Variance; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D009996:Osmotic Fragility / Q000187:drug effects*; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000378:metabolism; D011247:Pregnancy
D008278:Magnesium Sulfate