Hypoglycaemic and hypolipidaemic effect of aqueous leaf extract of Murraya koenigii in normal and alloxan-diabetic rats.
The hypoglycaemic effect of aqueous leaf extract of Murraya koenigii was studied in normal and alloxan-induced diabetic rats. The extract was administered orally at 100 mg/Kg, 150 mg/Kg and 200 mg/Kg bodyweight each to respective groups of animals (Groups I, II and III) for seven days. Group IV received normal saline and served as control for the normal rats. For the alloxan-induced diabetic rats, the same dosage pattern was administered to three groups of rats for seven days (Groups V, VI and VII) while group VIII which received normal saline served as control. At the various dose levels administered, the glucose lowering effect was more pronounced in the alloxan-diabetic rats than in control rats. When compared with chlorpropamide, the glucose lowering effect of aqueous extract of Murraya koenigii was significantly (p < 0.05) lower at the dose levels administered in both normal and alloxan-diabetic rats.
Lawal
H A
HA
Department of Biochemistry, Bayero University, Kano, Nigeria.
Atiku
M K
MK
Khelpai
D G
DG
Wannang
N N
NN
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D002747:Chlorpropamide / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D032101:Murraya / Q000737:chemistry; D018515:Plant Leaves; D028321:Plant Preparations / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D028321:Plant Preparations; D002747:Chlorpropamide