First report of tirofiban-induced anemia (found in combination with severe thrombocytopenia).
We describe the case of a 58-year-old man who developed acute severe anemia and thrombocytopenia after the administration of tirofiban following coronary artery angioplasty. The intravenous administration of IgG immunoglobulin completely resolved both the anemia and the thrombocytopenia. Although thrombocytopenia has been reported as a sequela to the use of tirofiban, there has been no prior report of a link between tirofiban use and anemia. Our successful resolution of both the anemia and the thrombocytopenia with immunoglobulin supports the theory that these severe sequelae of tirofiban are of autoimmune origin.
1st Cardiology Department, Evagelismos Hospital, 45-47 Ypsilantou Str., Athens, Greece.
Dimitris
D
Sakellariou
Socrates
S
Pastromas
Spyridon
S
Koulouris
Antonis S
AS
Manolis
D000208:Acute Disease; D000740:Anemia / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D015906:Angioplasty, Balloon, Coronary; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007155:Immunologic Factors / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D013997:Time Factors; D000077466:Tirofiban; D016896:Treatment Outcome; D014443:Tyrosine / Q000009:adverse effects / Q000031:analogs & derivatives*
D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D010975:Platelet Aggregation Inhibitors; D014443:Tyrosine; D000077466:Tirofiban