[Effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice].
OBJECTIVE
To study the effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice.


METHODS
75 mice were divided into five groups. After treated with curcumin 6 and 9 mice of each group were sacrificed on day 14 and 42 respectively to take their blood and lung tissue. The level of TNF-alpha and TGF-beta1 was observed by ELISA.


RESULTS
The infection reaction of lung tissue and fibrosis in model group was obvious. Compared with sham operation group, TNF-alpha and TGF-beta1 in serum and lung tissue increased significantly(P<0.01), but decreased in different degrees after treated with curcumin(P<0.05).


CONCLUSIONS
Curcumin can decrease the level of TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice and have the anti-fibrosis role by deregulating cytokine level.
Jiang
Zhen-you
ZY
Department of Microbiology and Immunology, Jinan University, Guangzhou, China. tjzhy@jnu.edu.cn
Zou
Lin
L
Shi
Shan-shan
SS
Lu
Yan-ru
YR
Dong
Jun
J
Yang
Chun-hua
CH
Lu
Ye-cheng
YC
Dai
Guo-kui
GK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D003474:Curcumin / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D006651:Histocytochemistry; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D011658:Pulmonary Fibrosis / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D012822:Silicon Dioxide; D053773:Transforming Growth Factor beta1 / Q000097:blood* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D012822:Silicon Dioxide; D003474:Curcumin