Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha.
The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1), is essential for viral biosynthesis in the liver. The dependency of HBV transcription on HNF4alpha links viral biosynthesis and persistence to a developmentally regulated transcription factor essential for host viability.
Department of Microbiology and Immunology College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
Lie
L
Li
Claudia E
CE
Oropeza
Bruno
B
Sainz
Susan L
SL
Uprichard
Frank J
FJ
Gonzalez
Alan
A
McLachlan
D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism; D004279:DNA, Viral / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D048788:Growth and Development; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology*; D051557:Hepatocyte Nuclear Factor 4 / Q000172:deficiency / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000821:virology; D051379:Mice; D008822:Mice, Transgenic; D009928:Organ Specificity; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics; D014158:Transcription, Genetic; D014779:Virus Replication / Q000502:physiology*
D001786:Blood Glucose; D004279:DNA, Viral; D051557:Hepatocyte Nuclear Factor 4; D012333:RNA, Messenger; D012367:RNA, Viral