TIM-1: a new player in transplant immunity.
Data have recently pointed to a possible regulatory function of T-cell immunoglobulin mucin protein 1 (TIM-1) during the alloimmune response. Cross-linking TIM-1 onto CD4+ T cells intensifies proinflammatory cytopathic allogeneic response and inhibits the development of natural and inducible regulatory T cells. The TIM-1 pathway might thus be a potential hurdle to the induction of tolerance in transplantation. Not unexpectedly, blocking the TIM-1 pathway is now emerging as a successful strategy to promote experimental peripheral tolerance.
The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Christophe
C
Mariat
Nicolas
N
Degauque
Terry B
TB
Strom
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology*; D009077:Mucins / Q000276:immunology; D011991:Receptors, Virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014181:Transplantation Immunology; D023001:Transplantation Tolerance / Q000276:immunology*
D000911:Antibodies, Monoclonal; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D009077:Mucins; D011991:Receptors, Virus