Leiomyosarcoma of the parotid gland in an HIV-positive patient: therapeutic approach, clinical course and review of the literature.
Leiomyosarcoma of the parotid gland is a rare tumor with only six cases reported in the english literature. To date, the association of this rare tumor with HIV infection has never been reported. We report the first case of a 19-year-old Caribbean woman affected by leiomyosarcoma of the parotid gland and HIV infection. Surgery, radiotherapy and chemotherapy used in this patient did not provide a good result in terms of overall survival. Intercurrent disease, opportunistic infection and chemotherapy cross-reaction have not been reported during this treatment regimen. The ability to use combined modality interventions in patients with secondary malignancies and immunosuppression requires further study with focus on both tolerance and efficacy.
Division of Medical Oncology A, National Cancer Institute, Aviano, Italy. mberretta@cro.it
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M
Berretta
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Zanet
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R
Taibi
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F
Martellotta
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P
Pavone
A
A
Bearz
C
C
Gobitti
E M
EM
Ciancia
V
V
Canzonieri
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Tirelli
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D015251:Epirubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008207:Lymphatic Metastasis / Q000473:pathology; D010307:Parotid Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D011878:Radiotherapy
D014408:Biomarkers, Tumor; D015251:Epirubicin; D007069:Ifosfamide