Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery.
Extreme makeover of cholesterol: Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the bilayer. Thus, disterolphospholipids (e.g. 1) are valuable new components for liposome formulation.
Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, CA 94143-0912, USA.
Zhaohua
Z
Huang
Mahmoud Reza
MR
Jaafari
Francis C
FC
Szoka
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D008081:Liposomes / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D010743:Phospholipids / Q000138:chemical synthesis / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D010743:Phospholipids; D004317:Doxorubicin