Exercise leukocyte profiles in healthy, type 1 diabetic, overweight, and asthmatic children.
Leukocytosis contributes to exercise-induced immune modulation, which is a mechanism of cardiovascular protection. However, this process is poorly defined in children. We therefore measured leukocytes in 45 healthy, 18 overweight, 16 type 1 diabetic, and 8 asthmatic children at pre, end-, and 30-min postexercise (30-min intermittent or 6-min continuous). In all groups, total leukocytes, neutrophils, lymphocytes, and monocytes increased at end-exercise, but returned to baseline by 30-min postexercise, including neutrophils, previously reported to remain elevated for at least some exercise formats. This highly preserved pattern indicates the importance of the adaptive response to physical stress across multiple health conditions.
Rosa
Jaime S
JS
Dept. of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA.
Schwindt
Christina D
CD
Oliver
Stacy R
SR
Leu
Szu-Yun
SY
Flores
Rebecca L
RL
Galassetti
Pietro R
PR
D000293:Adolescent; D001249:Asthma / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005080:Exercise Test; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D050177:Overweight / Q000097:blood*; D005082:Physical Exertion / Q000502:physiology*