Accommodation measured with optical coherence tomography in patients with Marfan's syndrome.
OBJECTIVE
To evaluate accommodation in patients with Marfan's syndrome using optical coherence tomography (OCT).


METHODS
Clinical case-control study.


METHODS
The study included 31 eyes of 31 patients with Marfan's syndrome and 31 eyes of 31 unaffected controls. Subgroups of eyes of patients with Marfan's syndrome with and without a subluxated lens also were compared.


METHODS
The changes in the anterior segment during accommodation and cycloplegia were studied with OCT.


METHODS
Accommodative power, anterior chamber depth (ACD), lens thickness, and pupil diameter.


RESULTS
No difference in accommodative power or ACD were found between the groups (P>0.05). The lens was thicker in the presence of Marfan's syndrome (P = 0.017 at baseline; P = 0.043 during accommodation; P = 0.046 during dilatation). The baseline pupil diameter was smaller in patients with Marfan's syndrome (P = 0.01), decreased less during accommodation (P = 0.02), and increased more during dilatation compared with controls (P<0.01). No difference was found in these variables between the subgroups of eyes of patients with Marfan's syndrome with and without a subluxated lens (P>0.05).


CONCLUSIONS
The results of this study suggested that even though the pupil and crystalline lens are affected in patients with Marfan's syndrome, these patients have the same ability to accommodate as normal subjects.
Konradsen
Tiina Rysä
TR
Anterior Segment Department, St. Erik's Eye Hospital, Stockholm, Sweden. tiina.konradsen@sankterik.se
Koivula
Annemari
A
Kugelberg
Maria
M
Zetterström
Charlotta
C
D000065:Accommodation, Ocular / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D000867:Anterior Chamber / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007498:Iris / Q000473:pathology; D007906:Lens Subluxation / Q000503:physiopathology*; D007908:Lens, Crystalline / Q000473:pathology; D008297:Male; D008382:Marfan Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D011680:Pupil; D041623:Tomography, Optical Coherence; D055815:Young Adult