Fluorescent organic nanoparticle formation in lysosomes for cancer cell recognition.
We present a convenient method to prepare fluorophores 3- or 3,7-divinyl substituted 10H-phenothiazines and their protonation forms can aggregate to become fluorescent organic nanoparticles (FONs) with bright fluorescent spots in the lysosomes of cancer cells but not normal cells.
Lin
Hsin-Hung
HH
Department of Chemistry, National Chung Hsing University, 250, Kuo Kuang Road, Taichung, 402, Taiwan, R.O.C.
Su
Sheng-Yuan
SY
Chang
Cheng-Chung
CC
D000818:Animals; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000737:chemistry / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology*; D010640:Phenothiazines / Q000138:chemical synthesis*; D011522:Protons
D005456:Fluorescent Dyes; D010640:Phenothiazines; D011522:Protons