Novel bile acids from bear bile powder and bile of geese.
Two new bile acids, tauroselocholic acid (1) and tauroansocholic acid (2), a new natural bile acid, cygnocholic acid (3) were respectively isolated from bear bile powder Selenaretos thibetanus CUVIER and bile of geese Anser anser domesticus, together with seven known compounds. By spectrum analysis of MS, 1D and 2D NMR, the structures of the new compounds were elucidated as 3alpha,7alpha,9alpha-trihydroxy-5beta-cholan-24-oic acid N-[2-sulfoethyl] amide (1), 3alpha,5,7alpha-trihydroxy-5beta-cholan-24-oic acid N-[2-sulfoethyl] amide (2) and 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid (3).
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.
Dan
D
Bi
Xing-Yun
XY
Chai
Yue-Lin
YL
Song
Yu
Y
Lei
Peng-Fei
PF
Tu
D000818:Animals; D001646:Bile / Q000737:chemistry*; D001647:Bile Acids and Salts / Q000737:chemistry*; D002793:Cholic Acids / Q000737:chemistry / Q000302:isolation & purification*; D005777:Geese; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011208:Powders / Q000737:chemistry; D001503:Ursidae
C540960:3alpha,7alpha,9alpha-trihydroxy-5beta-cholan-24-oic acid N-(2-sulfoethyl) amide; D001647:Bile Acids and Salts; D002793:Cholic Acids; D011208:Powders; C540961:tauroansocholic acid