The genomic 'inner fish' and a regulatory enigma in the vertebrates.
Information on how genomic information from fish to human encodes the same tissues has until now emerged one gene at a time. The study published in this issue now provides lists of genes and their expression levels for 20 vertebrate tissues spanning 450 million years of vertebrate evolution. It reveals a core set of genes with similar tissue-expression patterns yet no common regulatory signatures--a gene-expression paradox.
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. malonej@niddk.nih.gov
John
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Malone
Brian
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Oliver
D000818:Animals; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D005796:Genes; D016678:Genome; D006801:Humans; D013045:Species Specificity; D014714:Vertebrates / Q000235:genetics*