Tripentones: a promising series of potent anti-cancer agents.
The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anti-cancer agents. These compounds belong to the tripentone family and are based on 9H-pyrrolo[1,2-a]indol-9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.
CERMN UPRES EA 4258 - FR CNRS 3038 INC3M, UFR des Sciences Pharmaceutiques-Université de Caen Basse-Normandie, Bd Becquerel 14032 Caen Cedex, France.
Christophe
C
Rochais
Patrick
P
Dallemagne
Sylvain
S
Rault
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D007939:Leukemia L1210 / Q000188:drug therapy; D008937:Mitomycins / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D008937:Mitomycins