[The influence of mexidol on the liver functions, structure, and parameters of lipid peroxidation under long-term hypodynamia conditions].
It is established that rabbits kept under the conditions of 30-day hypodynamia with high-grade feeding exhibit disorders in both structure and functions of the liver, which are classified as nonalcoholic type fatness. Other disturbances are an increase in the activity of aspartate aminotransferase (AsAT) and alanine aminotransferase (AlAT) and a decrease in the total protein content predominantly at the expense of albumin. The development of a syndrome of mesenchymal inflammation is manifested by a relative growth of the alpha1, alpha2 and gamma-protein fractions. Pronounced violations of the lipid metabolism were manifested by a growth in the content of beta-lipoproteins, triglycerides, general cholesterol, and low-density lipoproteins and by a decrease in the level of high-density lipoproteins in the blood serum of animals. An increase in the content of malonic dialdehyde was accompanied by a drop in the activity of catalases in the blood serum and erythrocytes of rabbits. Investigation of the morphology of liver tissues showed evidence for small- and large-drop diffuse steatosis, which was most expressed in the central zones of lobes. Using of cytochrome C and mexidol, it is possible to reduce the expression of disorders to various degrees and, in some cases, to prevent the development of pathological changes.
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D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D045304:Cytochromes c / Q000494:pharmacology; D004912:Erythrocytes / Q000201:enzymology; D018476:Hypokinesia / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010084:Oxidation-Reduction; D010847:Picolines / Q000494:pharmacology*; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010847:Picolines; D014280:Triglycerides; C070020:emoxypine succinate; D045304:Cytochromes c; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase