Effectiveness of two pertussis vaccines in preterm Danish children.
Reduced immunogenicity in preterm children has been observed for pertussis vaccines. How immunogenicity relates to clinical protection is not well-established for pertussis, and the corresponding reduction, if any, in post-licensure vaccination effectiveness among preterm children has not been determined. We conducted a nationwide cohort study of 879,424 Danish children including 1553 cases of pertussis hospitalisation. The effectiveness of pertussis vaccination, both whole-cell and acellular, was evaluated in preterm and full-term children. The effectiveness of a completed primary series of pertussis vaccination, whole-cell or acellular, was similar in preterm and full-term children.
Hviid
Anders
A
Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen S, Denmark. aii@ssi.dk
D015331:Cohort Studies; D003718:Denmark; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000276:immunology*; D010567:Pertussis Vaccine / Q000627:therapeutic use*; D016896:Treatment Outcome; D022282:Vaccines, Acellular / Q000627:therapeutic use; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control*
D010567:Pertussis Vaccine; D022282:Vaccines, Acellular