Circadian regulation of DNA excision repair: implications for chrono-chemotherapy.
The mammalian circadian system synchronizes organisms' daily cyclical physiology from gene expression to gross behavioral patterns. A new study from our group suggests that DNA repair is also intimately linked to circadian rhythm. Since the repair of DNA lesions contributes to the resistance of chemotherapy with DNA damaging agents such as cisplatin, understanding the fundamental molecular mechanism regulating DNA repair pathways is important for cancer therapy. Here we review the significance of the connection linking the circadian clock with nucleotide excision repair and discuss potential implications for chemotherapy.
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Tae-Hong
TH
Kang
Aziz
A
Sancar
D056930:ARNTL Transcription Factors; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D002940:Circadian Rhythm / Q000235:genetics* / Q000502:physiology; D056931:Cryptochromes; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism; D055870:Drug Chronotherapy; D005420:Flavoproteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D056950:Period Circadian Proteins; D051716:Replication Protein A / Q000235:genetics / Q000378:metabolism; D051758:Transcription Factor TFIIH / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D051760:Xeroderma Pigmentosum Group A Protein / Q000235:genetics / Q000378:metabolism
D056930:ARNTL Transcription Factors; D000970:Antineoplastic Agents; D051792:Basic Helix-Loop-Helix Proteins; D056931:Cryptochromes; D004268:DNA-Binding Proteins; D005420:Flavoproteins; D047908:Intracellular Signaling Peptides and Proteins; D056950:Period Circadian Proteins; D051716:Replication Protein A; D051758:Transcription Factor TFIIH; D051760:Xeroderma Pigmentosum Group A Protein; C538960:BMAL1 protein, human; C539022:PER1 protein, human; C497167:RPA1 protein, human; C497314:XPA protein, human