Electrical-sensitive nanoparticle composed of chitosan and tetraethyl orthosilicate for controlled drug release.
In the present study, the nanoparticles with size of 50-130 nm composed of chitosan (CS) and tetraethyl orthosilicate (TEOS), which showed electrically-controlled release profile, were prepared. Myoglobin was encapsulated into the nanoparticles with an encapsulation efficiency as high as 91.5% and a maximum loading capacity of 70.2% that can be achieved. Here, TEOS was hydrolyzed and condensed to form interpenetration network with CS. Increase of TEOS content results in a shift of the release profile from swelling-controlled towards diffusion-controlled mechanism. The "slow-to-burst" and "near-zero" release of the myoglobin can be effectively controlled by applying DC electric field between "on" and "off".
Department of Materials Sciences and Engineering, National Chiao Tung University, Hsinchu, Taiwan, 300, ROC.
Kun-Ho
KH
Liu
Ting-Yu
TY
Liu
Dean-Mo
DM
Liu
San-Yuan
SY
Chen
D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D017640:Silicates / Q000737:chemistry*
D004364:Pharmaceutical Preparations; D017640:Silicates; D048271:Chitosan