Development of a cold dialysate regeneration system for home hemodialysis.
OBJECTIVE
Because longer and/or more frequent dialysis has potential clinical benefits, home hemodialysis (HHD) systems should provide flexible renal replacement therapies. We propose a new cold dialysate regeneration system that requires 10 l per treatment for HHD.


METHODS
We designed a dialysate regeneration system using cold dialysate and 2 activated carbon columns alternatively switched between adsorption and desorption. Urea adsorption ratios were compared in three different conditions; cold dialysate (5.7 degrees C), normal dialysate (36.8 degrees C), and cold dialysate with washing. In vivo tests (n = 8) were conducted to validate this system.


RESULTS
The urea removal ratios were 20.0 +/- 1.7% in cold dialysate, 36.0 +/- 1.7% in normal dialysate, and 82.5 +/- 1.2% in cold dialysate with washing. In animal experiments, the urea reduction ratio was 60.9 +/- 6.3%, Kt/V was 1.0 +/- 0.2, and serum electrolytes remained stable.


CONCLUSIONS
The proposed cold dialysate regeneration system using a small volume of dialysate will be useful for HHD.
Kim
Ji Hyun
JH
Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Mich., USA.
Kim
Jeong Chul
JC
Moon
Jin-Hee
JH
Park
Joong Yull
JY
Lee
Kyoung Kap
KK
Kang
Eungtaek
E
Kim
Hee Chan
HC
Min
Byoung Goo
BG
Ronco
Claudio
C
D000327:Adsorption; D000818:Animals; D002606:Charcoal / Q000737:chemistry / Q000627:therapeutic use*; D003080:Cold Temperature; D015314:Dialysis Solutions / Q000737:chemistry / Q000627:therapeutic use; D004285:Dogs; D004867:Equipment Design; D006437:Hemodialysis, Home / Q000295:instrumentation*; D006801:Humans; D008297:Male; D014508:Urea / Q000737:chemistry*
D015314:Dialysis Solutions; D002606:Charcoal; D014508:Urea