Three-dimensional biodegradable structures fabricated by two-photon polymerization.
Two-photon polymerization has been employed to fabricate three-dimensional structures using the biodegradable triblock copolymer poly(epsilon-caprolactone-co-trimethylenecarbonate)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone-co-trimethylenecarbonate) with 4,4'-bis(diethylamino)benzophenone as the photoinitiator. The fabricated structures were of good quality and had four micron resolution. Initial cytotoxicity tests show that the material does not affect cell proliferation. These studies demonstrate the potential of two-photon polymerization as a technology for the fabrication of biodegradable scaffolds for tissue engineering.
Claeyssens
Frederik
F
Engineering Materials Department, Biomaterials and Tissue Engineering Group, Kroto Research Institute, University of Sheffield, Broad Lane, Sheffield S3 7HQ, United Kingdom. f.claeyssens@sheffield.ac.uk
Hasan
Erol A
EA
Gaidukeviciute
Arune
A
Achilleos
Demetra S
DS
Ranella
Anthi
A
Reinhardt
Carsten
C
Ovsianikov
Aleksandr
A
Shizhou
Xiao
X
Fotakis
Costas
C
Vamvakaki
Maria
M
Chichkov
Boris N
BN
Farsari
Maria
M
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001673:Biodegradation, Environmental; D049109:Cell Proliferation; D004867:Equipment Design; D008027:Light; D051379:Mice; D008807:Mice, Inbred BALB C; D008956:Models, Chemical; D041681:NIH 3T3 Cells; D010777:Photochemistry / Q000379:methods; D017785:Photons; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods
D001672:Biocompatible Materials; D011108:Polymers