Molecular and biochemical pharmacology of the histamine H4 receptor.
The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H4 receptor.
Leurs
Rob
R
Department of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, VU University Amsterdam, Amsterdam, The Netherlands. leurs@few.vu.nl
Chazot
Paul L
PL
Shenton
Fiona C
FC
Lim
Herman D
HD
de Esch
Iwan J P
IJ
D000818:Animals; D001665:Binding Sites; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D010802:Phylogeny; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D011968:Receptors, Histamine / Q000235:genetics / Q000502:physiology; D000074040:Receptors, Histamine H4; D013045:Species Specificity
C418607:HRH4 protein, human; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4