Increased serum oxidative stress in patients with severe mitral regurgitation: a new finding and potential mechanism for atrial enlargement.
OBJECTIVE
The aim of this study was to examine the serum oxidative stress in patients with severe mitral regurgitation.


METHODS
This study analyzed serum oxidative stress index in patients with severe mitral regurgitation [persistent atrial fibrillation (AF) or sinus rhythm], paroxysmal lone AF patients and healthy subjects.


RESULTS
The serum oxidative stress index was significantly higher in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p<0.0001). Left atrial size was significantly larger in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p<0.0001). The oxidative stress index significantly and positively correlated with left atrial size in the overall study population (r=0.439, p=0.0008).


CONCLUSIONS
This study provides new evidence of increased oxidative stress in human severe mitral regurgitation, probably contributing to atrial enlargement.
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China. chenmien@ms76.hinet.net
Mien-Cheng
MC
Chen
Jen-Ping
JP
Chang
Wen-Hao
WH
Liu
Cheng-Hsu
CH
Yang
Chien-Jen
CJ
Chen
Chih-Yuan
CY
Fang
Yuan-Kai
YK
Hsieh
Ya-Hui
YH
Wang
Hsueh-Wen
HW
Chang
D000975:Antioxidants / Q000378:metabolism; D005260:Female; D006325:Heart Atria / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000097:blood* / Q000378:metabolism*; D008955:Models, Cardiovascular; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress
D000975:Antioxidants; D016877:Oxidants