Severe acute graft versus host disease after lung transplant: report of a case successfully treated with high dose corticosteroids.
Acute graft vs host disease is an uncommon and usually fatal complication of lung transplant for which no effective therapy exists. All 8 patients with grade 3 to 4 acute graft vs host disease after lung transplantation described in literature died within 208 days. We report a patient with grade 3 to 4 acute graft vs host disease after bilateral lung transplantation who was successfully treated with high-dose corticosteroids after basiliximab and extracorporeal photopheresis were unsuccessful.
Respiratory Disease Section, Department of Clinical Medicine and Immunology, University Hospital of Siena, Siena, Italy.
Antonella
A
Fossi
Luca
L
Voltolini
Rita
R
Filippi
Luca
L
Luzzi
Franco Laghi
FL
Pasini
Bruna
B
Marchi
Giuseppe
G
Gotti
Paola
P
Rottoli
D000208:Acute Disease; D000328:Adult; D001987:Bronchiectasis / Q000601:surgery*; D002925:Ciliary Motility Disorders / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000008:administration & dosage*; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007262:Infusions, Intravenous; D016040:Lung Transplantation / Q000276:immunology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology
D005938:Glucocorticoids; D008775:Methylprednisolone