Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function.
With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.
Walmsley
Sarah R
SR
Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK. s.walmsley@sheffield.ac.uk
Chilvers
Edwin R
ER
Whyte
Moira K B
MK
D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D022423:Myeloid Cells / Q000276:immunology* / Q000378:metabolism*
D051793:Hypoxia-Inducible Factor 1