Molecular rods with oligospiroketal backbones as anchors in biological membranes.
Getting stuck in: A hydrophobic molecular rod with terminal fluorescent moieties has been synthesized. The insertion of the rod into membranes was investigated and shown to incorporate efficiently into model and biological membranes (see picture; gray C, blue N, red O). Those rods can be used as stable membrane-associated anchors for functionalization of membrane surfaces.
Müller
Peter
P
Institut für Biologie, Humboldt-Universität zu Berlin, Invalidenstrasse 42, 10115 Berlin, Germany.
Nikolaus
Jörg
J
Schiller
Sabine
S
Herrmann
Andreas
A
Möllnitz
Kristian
K
Czapla
Sylvia
S
Wessig
Pablo
P
D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D010455:Peptides / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry*
D005456:Fluorescent Dyes; D005663:Furans; D010455:Peptides; D013141:Spiro Compounds; C520774:spiroketal