Allylic amination by a DNA-diene-iridium(I) hybrid catalyst.
DNA hybrid catalysis goes organometallic: A DNA strand functionalized with diene ligands forms iridium(I) complexes that can efficiently catalyze an allylic amination in aqueous medium (see scheme). The DNA-based complexes show high stability and activity, and their secondary structure influences the stereoselectivity of the reaction.
Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, 69120 Heidelberg, Germany.
Pierre
P
Fournier
Roberto
R
Fiammengo
Andres
A
Jäschke
D000586:Amination; D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D007700:Kinetics; D009841:Oligonucleotides / Q000737:chemistry; D011090:Polyenes / Q000737:chemistry*; D013237:Stereoisomerism
D009841:Oligonucleotides; D011090:Polyenes; D007495:Iridium; D004247:DNA