A new norlignan from Taxodium ascendens.
A new norlignan, (2R,3R,4S,5S)-2,4-bis(4-hydroxyphenyl)-3,5-dihydroxy-tetrahydropyran (1), together with 9 known compounds were isolated from the branches and leaves of Taxodium ascendens. Their structures were mainly determined on the basis of MS, IR, 1D and 2D NMR spectral evidences. Methanol extract showed inhibitory activity on carbonic anhydrase II with an IC(50) value of 4.27 microg/ml, acetone extract and methanol extract inhibited activity of cathepsin B with IC(50) values of 2.12 and 3.71 microg/ml, respectively.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Yu Mei
YM
Zhang
Ning Hua
NH
Tan
Guang Zhi
GZ
Zeng
Abiodun Humphrey
AH
Adebayo
Chang Jiu
CJ
Ji
D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002403:Cathepsins / Q000037:antagonists & inhibitors; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves; D018547:Plant Stems; D032489:Taxodium / Q000737:chemistry*
C544623:2,4-bis(4-hydroxyphenyl)-3,5-dihydroxytetrahydropyran; D002257:Carbonic Anhydrase Inhibitors; D017705:Lignans; D010936:Plant Extracts; D002403:Cathepsins