Circulating IL-8 levels in heart failure patients with and without metabolic syndrome.
BACKGROUND
It has been suggested that the metabolic syndrome (MetS) is associated with increased risk for heart failure (HF) and progression of HF. However, the underlying mechanisms are unclear. We tested whether the presence of the MetS would be associated with the increased degree of inflammatory state in HF.


METHODS
Ninety-one eligible consecutive stable HF patients participated in this cross-sectional study. Anthropometric measurements were carried out and serum concentrations of lipoproteins, apolipoproteins (apoB, apoAI) and high sensitivity C-reactive protein (hsCRP) were measured. The simultaneous measurement of 17 cytokines using bioplex analysis was used.


RESULTS
Thirty-five subjects (39% of total, 48% of males and 31% of females) were classified as having the MetS in total HF patients. Serum concentrations of apoB (p<0.005) were significantly higher and the ratio of apoAI and apoB was significantly lower (p<0.01) in HF patients with MetS than those without MetS. Plasma levels of IL-8 (p<0.05) were significantly higher in HF patients with MetS than those without MetS. In addition, serum concentrations of hsCRP (p<0.005) were significantly higher in HF patients with MetS compared to those without MetS.


CONCLUSIONS
The MetS in HF is associated with increased degree of inflammation, which provides information regarding the relationship between inflammation and HF with MetS.
Department of Food and Nutrition, Korea University, Seoul, Republic of Korea.
Min-Jeong
MJ
Shin
Kyung Hye
KH
Lee
Ji Hyung
JH
Chung
Yoo Kyoung
YK
Park
Mi Kyung
MK
Choi
Jaewon
J
Oh
Ji Won
JW
Choi
Sang-Hak
SH
Lee
Namsik
N
Chung
Seok-Min
SM
Kang
D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000150:complications*; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications*; D008875:Middle Aged
D001786:Blood Glucose; D016209:Interleukin-8; D008074:Lipoproteins; D002097:C-Reactive Protein