Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families.
Multiple sclerosis (MS) is a complex trait with a significant genetic component. Recent work has implicated the ST8SIA1 gene, encoding a ganglioside synthase, in susceptibility to the disease, perhaps with a parent-of-origin effect. In this investigation of 1318 MS patients from 756 Canadian families, we analysed the transmission of the four single nucleotide polymorphisms in ST8SIA previously shown to be associated with MS. No significant association was found in the entire sample or when stratifying by transmitting parent, indicating that this gene plays little or no role in susceptibility to MS in the Canadian population.
Wellcome Trust Centre for Human Genetics, Oxford, UK.
Sreeram V
SV
Ramagopalan
Katie M
KM
Morrison
Andrea
A
Para
Adam
A
Handel
Giulio
G
Disanto
Lahiru
L
Handunnetthi
Sarah M
SM
Orton
A Dessa
AD
Sadovnick
George C
GC
Ebers
D020022:Genetic Predisposition to Disease; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012799:Sialyltransferases / Q000235:genetics*
D012799:Sialyltransferases; C043662:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase