Effects of Carnoy's solution on blood vessels of the axillary fossa of rats.
Carnoy's solution is applied to reduce the recurrence of odontogenic keratocysts and unicystic ameloblastomas. The deleterious action of this fixative on nerves has been studied but no attention has been paid to its effects on nearby vessels. The aim of this study was to investigate the effects of Carnoy's solution on blood vessels. The rat axillary artery and vein were surgically exposed, soaked with Carnoy's solution and kept in place for 2, 5 or 10 min, depending on the treatment group. The 5-min group was followed for 1, 2 and 3 weeks postoperatively. The vessels in the 2-min and 5-min exposure groups showed histological changes to the vessels, represented by focal loss of the endothelium and hyalinization of the wall. These alterations increased in the 10-min group. The vessels in the 3-week observation period revealed signs of recovery. It is concluded that Carnoy's solution can damage blood vessels but the process is reversible for exposure times less than 5 min.
Department of Cranio-Maxillofacial Surgery, University Hospital, University of Berne, Switzerland. nikola.saulacic@insel.ch
N
N
Saulacic
Z
Z
Stajcic
Lj
Lj
Stojcev Stajcic
A
A
Piattelli
T
T
Iizuka
T
T
Lombardi
D019342:Acetic Acid / Q000494:pharmacology*; D000818:Animals; D001365:Axilla / Q000294:innervation; D001366:Axillary Artery / Q000187:drug effects* / Q000473:pathology; D001367:Axillary Vein / Q000187:drug effects* / Q000473:pathology; D001369:Axons / Q000187:drug effects / Q000473:pathology; D002725:Chloroform / Q000494:pharmacology*; D004547:Elastic Tissue / Q000187:drug effects / Q000473:pathology; D042783:Endothelial Cells / Q000187:drug effects / Q000473:pathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005355:Fibrosis; D005404:Fixatives / Q000494:pharmacology*; D006818:Hyalin / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012583:Schwann Cells / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology; D014945:Wound Healing / Q000502:physiology
C033474:Carnoy's solution; D005404:Fixatives; D000431:Ethanol; D002725:Chloroform; D019342:Acetic Acid