Biodefunctionalization of functionalized single-walled carbon nanotubes in mice.
Chemically modified carbon nanotubes with hydrophilic functionalities such as polyethylene glycols (PEGs) are widely pursued for potential biological and biomedical applications. In this study, PEGylated single-walled carbon nanotubes (PEG-SWNT) were intravenously administrated into mice to study their biodefunctionalization in vivo by using complementary Raman and photoluminescence measurements. There was meaningful defunctionalization of PEG-SWNT in liver over time, but not in spleen under similar conditions. The evidence from spectroscopic characterization and analyses is presented, and mechanistic implications are discussed.
Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Sheng-Tao
ST
Yang
Haifang
H
Wang
Mohammed J
MJ
Meziani
Yuanfang
Y
Liu
Xin
X
Wang
Ya-Ping
YP
Sun
D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D001711:Biotransformation; D008099:Liver / Q000378:metabolism*; D051379:Mice; D037742:Nanotubes, Carbon / Q000737:chemistry*; D011092:Polyethylene Glycols
D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D011092:Polyethylene Glycols