Levels of soluble CD40 ligand and P-Selectin in nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) is linked to an increased risk of cardiovascular disease. We aimed to research whether the levels of soluble P-selectin (sP-selectin) and soluble CD40 ligand (sCD40L), markers of endothelial function, are altered in subjects with NAFLD having no confounding factors for atherosclerosis. sCD40L, sP-selectin, and high-sensitivity C-reactive protein (hsCRP) levels, and homeostasis model assessment of insulin resistance (HOMA-IR) indexes were measured in 50 NAFLD subjects and 30 healthy controls. sCD40L, sP-selectin, and hsCRP levels were not significantly different between two groups (P = 0.48, 0.51, and 0.34, respectively). Body mass index, waist circumference, and insulin levels and HOMA indexes were significantly higher in subjects with NAFLD (all P < 0.001). The present data show that sCD40L and sP-selectin may not contribute to the accelerated atherogenesis associated with this clinically relevant condition.
Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
Cemal Nuri
CN
Ercin
Teoman
T
Dogru
Serkan
S
Tapan
Yildirim
Y
Karslioglu
Cem
C
Haymana
Selim
S
Kilic
Alper
A
Sonmez
Zeki
Z
Yesilova
Ahmet
A
Uygun
Mustafa
M
Gulsen
Sait
S
Bagci
M
M
Kemal Erbil
D000328:Adult; D050197:Atherosclerosis / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D023201:CD40 Ligand / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood; D005234:Fatty Liver / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D019007:P-Selectin / Q000097:blood*; D012307:Risk Factors; D014421:Turkey
D019007:P-Selectin; D023201:CD40 Ligand; D002097:C-Reactive Protein