The use of plasma rich in growth factors on wound healing in the skin: experimental study in rabbits.
The objective of this study was to use autologous plasma rich in growth factors (PRGF) on wound healing in the skin in New Zealand albino rabbits and to study reepithelialisation and inflammation at 7 and 28 days. A prospective study carried out on 20 adult rabbits. Two wounds were made on the in the skin on the back of each animal; one control, and the other in which PRGF was applied. The PRGF preparation was obtained from 10 ml of whole blood. The reepithelialisation and inflammation of wounds were measured at 7 and 28 days. Reepithelialisation improved in skin at 7 days (P = 0.007), with resolution of the inflammatory process (P = 0.005), having significant differences with respect to the control. Therefore, PRGF accelerates reepithelialisation and reduces inflammation at 7 days in skin.
Department of Oral Medicine, Faculty of Medicine and Dentistry, University of Murcia, Spain.
Francesco
F
Molina-Miñano
Péa
P
López-Jornet
Fabio
F
Camacho-Alonso
Vicente
V
Vicente-Ortega
D000279:Administration, Cutaneous; D000818:Animals; D004195:Disease Models, Animal; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D008297:Male; D053657:Platelet-Rich Plasma; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D014950:Wounds, Penetrating / Q000473:pathology / Q000628:therapy*
D036341:Intercellular Signaling Peptides and Proteins