[Rhino-orbito-cerebral mucormycosis in the diabetic: a better known pathology in Tunisia].
This is a retrospective study including 17 patients with rhino-orbito-cerebral mucormycosis diagnosed in a period of 16 years, between 1992 and 2007, in 8 men and 9 women. All patients were diabetic with ketoacidosis diabetes in 8 cases. Necrosis facial and ophthalmic symptoms were the most frequent presenting manifestations. The diagnosis was confirmed by mycological examination, with or without histopathology, identifying Rhizopus oryzae in 12 cases. Treatment consisted in systemic amphotericin B combined with surgical treatment in only 7 cases. The mortality rate was high (65%) due principally to the delay in diagnosis and absence of surgical treatment.
Service de parasitologie-mycologie, CHU la Rabta, Tunis, Tunisie. emna.chaker@rns.tn
S
S
Anane
E
E
Kaouech
S
S
Belhadj
L
L
Ammari
R
R
Abdelmalek
T
T
Ben Chaabane
S
S
Ben Lakhal
A
A
Cherif
M
M
Ammamou
K
K
Ben Fadhel
K
K
Kallel
E
E
Chaker
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use; D048909:Diabetes Complications / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D016883:Diabetic Ketoacidosis / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009091:Mucormycosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D009668:Nose Diseases / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D009916:Orbital Diseases / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D010254:Paranasal Sinus Diseases / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D012233:Rhizopus / Q000302:isolation & purification; D014416:Tunisia / Q000453:epidemiology
D000935:Antifungal Agents; D000666:Amphotericin B