[Effects of panthenol and carnitine on aldehyde metabolic enzymes in rats with tetrachloromethane-induced liver injury].
Tetrachloromethane (2 g/kg, intragastric) produced a decrease in the activity of NAD- and NADH- dependent aldehyde dehydrogenases with high Km for aldehydes in rat liver. Panthenol and L-carnitine administered separately normalized the activity of aldehyde dehydrogenases, while a combination of the drugs did not produce any significant effect.
Satanovskaia
V I
VI
Pron'ko
P S
PS
Gaĭshmanova
A V
AV
Miskevich
D A
DA
D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D002331:Carnitine / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D004347:Drug Interactions; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000447:Aldehydes; D010205:Pantothenic Acid; C007288:dexpanthenol; D000445:Aldehyde Oxidoreductases; D002331:Carnitine