T2-enhanced tensor diffusion trace-weighted image in the detection of hyper-acute cerebral infarction: comparison with isotropic diffusion-weighted image.
OBJECTIVE
Although isotropic diffusion-weighted imaging (isoDWI) is very sensitive to the detection of acute ischemic stroke, it may occasionally show diffusion negative result in hyper-acute stroke. We hypothesize that high diffusion contrast diffusion trace-weighted image with enhanced T2 may improve stroke lesion conspicuity.


METHODS
Five hyper acute stroke patients (M:F=0:5, average age=61.8+/-20.5 y/o) and 16 acute stroke patients (M:F=11:5, average age=67.7+/-12 y/o) were examined six-direction tensor DWIs at b=707s/mm(2). Three different diffusion-weighted images, including isotropic (isoDWI), diffusion trace-weighted image (trDWI) and T2-enhanced diffusion trace-weighted image (T2E_trDWI), were generated. Normalized lesion-to-normal ratio (nLNR) and contrast-to-noise ratio (CNR) of three diffusion images were calculated from each patient and statistically compared.


RESULTS
The trDWI shows better nLNR than isoDWI on both hyper-acute and acute stroke lesions, whereas no significant improvement in CNR. Nevertheless, the T2E_trDWI has statistically superior CNR and nLNR than those of isoDWI and trDWI in both hyper-acute and acute stroke.


CONCLUSIONS
We concluded that tensor diffusion trace-weighted image with T2 enhancement is more sensitive to stroke lesion detection, and can provide higher lesion conspicuity than the conventional isotropic DWI for early stroke lesion delineation without the need of high-b-value technique.
Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan, ROC.
Ming-Chung
MC
Chou
Wen-Sheng
WS
Tzeng
Hsiao-Wen
HW
Chung
Chao-Ying
CY
Wang
Hua-Shan
HS
Liu
Chun-Jung
CJ
Juan
Chung-Ping
CP
Lo
Chun-Jen
CJ
Hsueh
Cheng-Yu
CY
Chen
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D002544:Cerebral Infarction / Q000150:complications* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020521:Stroke / Q000209:etiology* / Q000473:pathology*