Candida keratitis after descemet stripping and automated endothelial keratoplasty.
OBJECTIVE
To report the donor-to-host transmission of Candida albicans after Descemet stripping and automated endothelial keratoplasty (DSAEK).


METHODS
An 80-year-old woman with pseudophakic bullous keratopathy developed an infiltrate in the donor corneal lenticule after DSAEK.


RESULTS
Donor corneoscleral rim cultures grew C. albicans. Gram stain of the removed corneal lenticule demonstrated budding yeast and pseudohyphae, and cultures yielded C. albicans. Despite topical and systemic antifungal therapy and therapeutic penetrating keratoplasty, the patient developed a blind painful eye and underwent enucleation.


CONCLUSIONS
This case report indicates that fungal keratitis may occur from donor-to-host transmission after DSAEK. The location of the infected tissue poses diagnostic and therapeutic challenges for the surgeon.
Koenig
Steven B
SB
Eye Institute, Froedtert and The Medical College of Wisconsin, Milwaukee, WI, USA. skoenig@mcw.edu
Wirostko
William J
WJ
Fish
Robert I
RI
Covert
Douglas J
DJ
D000369:Aged, 80 and over; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology / Q000601:surgery / Q000635:transmission*; D003315:Cornea / Q000382:microbiology*; D016039:Corneal Transplantation / Q000009:adverse effects*; D003886:Descemet Membrane / Q000601:surgery; D018562:Disease Transmission, Infectious; D004728:Endothelium, Corneal / Q000637:transplantation*; D015821:Eye Infections, Fungal / Q000382:microbiology / Q000601:surgery / Q000635:transmission*; D005260:Female; D006801:Humans; D007634:Keratitis / Q000382:microbiology* / Q000601:surgery; D015948:Keratoplasty, Penetrating; D014019:Tissue Donors