Association between sleep architecture and measures of body composition.
OBJECTIVE
To determine whether slow wave sleep (SWS) is inversely associated with body mass index (BMI) and other measures of body composition.


METHODS
Cross-sectional, observational study.


METHODS
Community-based.


METHODS
2745 older men from the MrOS Sleep Study who completed polysomnography.


METHODS
N/A.


RESULTS
SWS as a percentage of total sleep duration was obtained from in-home, overnight polysomnography. Measures of body composition including BMI, weight, waist circumference and total body fat mass were determined by standard techniques. Other covariates in the analysis were age, race/ethnicity, clinic site, physical activity, respiratory disturbance index (RDI), total sleep time, and sleep efficiency. In the multivariate analysis, there was a significant inverse association between quartiles of SWS and BMI (P-trend = 0.0095). Older men in the lowest quartile of SWS had an average BMI of 27.4 kg/m2, compared to 26.8 for those in the highest quartile of SWS. This association was attenuated in men with RDI > or = 15. Furthermore, participants in the lowest quartile of SWS had a 1.4-fold increased odds for obesity (P = 0.03, 95% CI 1.0, 1.8) compared to those in the highest quartile. A similar inverse association between SWS and waist circumference as well as weight was observed. REM sleep was not associated with measures of body composition.


CONCLUSIONS
Independent of sleep duration, percentage time in SWS is inversely associated with BMI and other measures of body composition in this population of older men. Participants in the lowest quartile of SWS (compared to those in the highest quartile) are at increased risk for obesity.
Division of Endocrinology, University of California San Francisco, San Francisco, CA 94110, USA. Madhu.Rao@ucsf.edu
Madhu N
MN
Rao
Terri
T
Blackwell
Susan
S
Redline
Marcia L
ML
Stefanick
Sonia
S
Ancoli-Israel
Katie L
KL
Stone
D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000503:physiopathology; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D015331:Cohort Studies; D006801:Humans; D008297:Male; D009765:Obesity / Q000503:physiopathology; D017286:Polysomnography; D012815:Signal Processing, Computer-Assisted; D012891:Sleep Apnea Syndromes / Q000503:physiopathology; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D049629:Waist-Hip Ratio