Antimicrobial activity of hydroxylbenzenesulfonailides derivatives of chitosan, chitosan sulfates and carboxymethyl chitosan.
Chitosan, carboxymethyl chitosan (CMCS) and chitosan sulfates (CSS) with different molecular weight were modified by reacting with 4-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride or 2-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride to give 12 kinds of new hydroxylbenzenesulfonailides derivatives of them. The preparation conditions of the derivatives were discussed in this paper, and their structures were characterized by FT-IR and 13C NMR spectroscopy. The solubility of the derivatives was measured in the experiment. In addition, their antimicrobial activities against four bacteria and five crop-threatening pathogenic fungi were tested in the experiment. Besides, the rule and mechanism of their antibacterial activities were discussed in this paper.
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. zhimeihappy@126.com
Zhimei
Z
Zhong
Pengcheng
P
Li
Ronge
R
Xing
Song
S
Liu
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001554:Benzene / Q000737:chemistry*; D055598:Chemical Phenomena; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D012995:Solubility; D013696:Temperature; D014867:Water / Q000737:chemistry
D000890:Anti-Infective Agents; C480355:chitosan sulfate; D014867:Water; D048271:Chitosan; D001554:Benzene