Do resident renal mast cells play a role in the pathogenesis of diabetic nephropathy?
Diabetic nephropathy is associated with high morbidity and mortality and the prevalence of this disease is continuously increasing world wide. Though, the major risk factors like hyperglycemia and hypertension play a pivotal role in the pathogenesis of diabetic nephropathy, the etiology of this insidious disorder is not well understood. Mast cells are pluripotent bone marrow derived cells that play a key role in inflammation. Degranulation of mast cells releases various mediators including inflammatory cytokines, endothelins, growth factors, and proteolytic enzymes. Infiltration of mast cells has been noted to occur in renal diseases. In addition, the renal density of mast cells is significantly increased in diabetic patients with nephropathy. It remains unclear whether resident renal mast cells derived mediators play a role in the pathogenesis of diabetic nephropathy. Recent studies suggest the involvement of renal mast cell infiltration and degranulation in diabetic nephropathy. The present review focuses on the role of resident renal mast cells in diabetic nephropathy.
Department of Physiology, Faculty of Medicine, University of Montreal, Succ. Centre-ville, Montreal, QC, H3C 3J7, Canada. pbala2006@gmail.com
Pitchai
P
Balakumar
Jayarami
J
Reddy
Manjeet
M
Singh
D000818:Animals; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007668:Kidney / Q000473:pathology*; D008407:Mast Cells / Q000473:pathology*