In vivo confocal microscopic evaluation of corneal changes in chronic Stevens-Johnson syndrome and toxic epidermal necrolysis.
OBJECTIVE
To describe corneal changes visible on in vivo confocal microscopy, in patients with debilitating ocular sequelae because of toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome (SJS).


METHODS
Forty-one eyes of 25 consecutive patients suffering from chronic TEN or SJS were studied using in vivo confocal microscopy.


RESULTS
Severe dry eye syndrome with no associated limbal stem cell deficiency (25 eyes, 16 patients, 61%) was the most frequent clinical pattern. Limbal stem cell deficiency was noted in 16 eyes (12 patients, 39%). Three patients had asymmetric disease. Confocal microscopy showed a consistent change in the superficial epithelial cells in both clinical presentations. Patients with dry eye syndrome had frequent pathological nerve damages, and the presence of dendritic cells was prevalent (65%). Inflammatory cells were observed in a large number in 4 of the 12 patients presenting neovascularization of the cornea.


CONCLUSIONS
The corneas of patients with chronic ocular sequelae linked to SJS and TEN present a number of abnormalities. In vivo confocal microscopy is a potentially useful tool for therapeutic indications and for follow-up of the debilitating chronic ocular problems associated with these diseases.
Vera
Liza S
LS
Department of Ophthalmology, Charles Nicolle Hospital, University of Rouen, Rouen, France. lizavera22@yahoo.fr
Gueudry
Julie
J
Delcampe
Agnes
A
Roujeau
Jean-Claude
JC
Brasseur
Gérard
G
Muraine
Marc
M
D000328:Adult; D002908:Chronic Disease; D003315:Cornea / Q000294:innervation; D003316:Corneal Diseases / Q000175:diagnosis*; D015352:Dry Eye Syndromes / Q000175:diagnosis*; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D016850:Limbus Corneae / Q000473:pathology*; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D009882:Ophthalmic Nerve / Q000473:pathology; D013234:Stem Cells / Q000473:pathology*; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis*