Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects.
This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.
Miyaki
Koichi
K
Department of Neurology, School of Medicine, Keio University, Tokyo, Japan. miyaki-keio@umin.net
Lwin
Htay
H
Masaki
Katsunori
K
Song
Yixuan
Y
Takahashi
Yoshimitsu
Y
Muramatsu
Masaaki
M
Nakayama
Takeo
T
D000328:Adult; D044466:Asian People; D015415:Biomarkers; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D007854:Lead / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011110:Polymorphism, Genetic; D000623:Porphobilinogen Synthase / Q000235:genetics*
D015415:Biomarkers; D007854:Lead; D000623:Porphobilinogen Synthase