Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death.
In the course of our search for neuroprotective agents, dysideamine (1), a new sesquiterpene aminoquinone, was isolated along with bolinaquinone (2) from Indonesian marine sponge of Dysidea sp. Compounds 1 and 2 showed neuroprotective effect against iodoacetic acid (IAA)-induced cell death at 10 microM concentration in mouse HT22 hippocampal neuronal cells. Dysideamine (1) inhibited production of reactive oxygen species (ROS) by IAA treatment, whereas it exhibited no effect on depletion of intracellular ATP of the IAA-treated HT22 cells. Moreover, 1 induced neurite outgrowth against mouse neuroblastoma Neuro 2A cells with increase of acetylcholinesterase (AChE) activity, which is a marker of neuronal differentiation.
Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Suita, Osaka 565-0871, Japan.
Hideaki
H
Suna
Masayoshi
M
Arai
Yoshie
Y
Tsubotani
Asami
A
Hayashi
Andi
A
Setiawan
Motomasa
M
Kobayashi
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D016227:Benzoquinones / Q000737:chemistry* / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects*; D002460:Cell Line; D002470:Cell Survival; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects; D019807:Iodoacetic Acid / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*
D016227:Benzoquinones; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D012717:Sesquiterpenes; C500927:bolinaquinone; C544078:dysideamine; D000110:Acetylcholinesterase; D019807:Iodoacetic Acid