Hybrid polymeric hydrogels for ocular drug delivery: nanoparticulate systems from copolymers of acrylic acid-functionalized chitosan and N-isopropylacrylamide or 2-hydroxyethyl methacrylate.
Nanoparticulate hybrid polymeric hydrogels (10-70 nm) have been obtained via the radical-induced co-polymerization of acrylic acid-functionalized chitosan with either N-isopropylacrylamide or 2-hydroxyethyl methacrylate, and the materials have been investigated for their ability to act as controlled release vehicles in ophthalmic drug delivery. Studies on the effects of network structure upon swelling properties, adhesiveness to substrates that mimic mucosal surfaces and biodegradability, coupled with in vitro drug release investigations employing ophthalmic drugs with differing aqueous solubilities, have identified nanoparticle compositions for each of the candidate drug molecules. The hybrid nanoparticles combine the temperature sensitivity of N-isopropylacrylamide or the good swelling characteristics of 2-hydroxyethyl methacrylate with the susceptibility of chitosan to lysozyme-induced biodegradation.
Barbu
Eugen
E
School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth PO12DT, UK. eugen@barbu@port.ac.uk
Verestiuc
Liliana
L
Iancu
Mihaela
M
Jatariu
Anca
A
Lungu
Adriana
A
Tsibouklis
John
J
D000178:Acrylamides / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D005123:Eye; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry; D008962:Models, Theoretical; D009113:Muramidase; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D013696:Temperature
D000178:Acrylamides; D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D020100:Hydrogels; D008689:Methacrylates; C005044:hydroxyethyl methacrylate; D048271:Chitosan; C067295:N-isopropylacrylamide; D009113:Muramidase