Polyacrylonitrile fibers efficiently loaded with tamoxifen citrate using wet-spinning from co-dissolving solution.
Tamoxifen citrate (TAM)-loaded polyacrylonitrile (PAN) fibers were prepared using an improved wet-spinning technique. TAM was used as a model drug to evaluate the potential application of the loaded fiber system for drug delivery. PAN was first homogeneously dissolved in the N,N-dimethylacetamide (DMAc) solution containing TAM and then the co-dissolving solution was solidified to prepare the fibers using a wet-spinning method. Chemical, morphological and mechanical property characterizations were carried out, as well as the studies of the drug release properties. TAM was successfully encapsulated into a monofilament fiber, and this system was stable in terms of high loading capacity and effectiveness in release. The diameter of drug-loaded fiber was in the range of 40-60 microm. The best values of the tensile strength at 2.968 cN/dtex and breaking elongation at 14.9% of drug-loaded fibers were obtained when the drug loading content was 23.1 wt.%. These characteristics were suitable for the weaving process. The in vitro release experiment indicated that constant drug release from the fiber was observed for a long duration of time. Kinetic studies demonstrated that the system followed the Higuchi kinetics. These findings demonstrate that controlled release of drugs from PAN fibers could be potentially useful in drug delivery systems.
Nie
Hua-Li
HL
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
Ma
Zong-Hui
ZH
Fan
Zai-Xia
ZX
Branford-White
Christopher J
CJ
Ning
Xin
X
Zhu
Li-Min
LM
Han
Jie
J
D000081:Acetamides / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry*; D000465:Algorithms; D001682:Biological Availability; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared; D013629:Tamoxifen / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D013718:Tensile Strength; D014961:X-Ray Diffraction / Q000379:methods
D000081:Acetamides; D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D013629:Tamoxifen; C010504:polyacrylonitrile; C013959:dimethylacetamide