FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients.
OBJECTIVE
The aim of this study was to describe the prevalence of atherosclerotic plaques based on [(18)F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in a large population characterized by high risk of cardiovascular disease.


METHODS
One hundred forty-one patients referred to our department for FDG-PET/CT for suspected lung cancer were re-evaluated for atherosclerotic lesions. Cardiovascular risk factors were analyzed based on patient records.


RESULTS
Forty-two percent of the patients had three cardiovascular risk factors or more. Nine percent of all plaques were assessed as active FDG-accumulating plaques, 88% were inactive calcified plaques, and 2% were mixed. The abdominal aorta was the vessel with the highest plaque count. Patients with one risk factor had significantly less active and inactive plaques.


CONCLUSIONS
The observed association between the numbers of cardiovascular risk factors and the numbers of FDG-accumulating plaques as well as calcified plaques further supports the validity and value of FDG-PET/CT in the non-invasive identification and characterization of atherosclerotic disease.
Wassélius
Johan A
JA
Department of Molecular Medicine and Surgery, The Karolinska Institute, Stockholm, Sweden johan.wasselius@karolinska.se
Larsson
Stig A
SA
Jacobsson
Hans
H
D000368:Aged; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18