In contrast to other stimulatory natural killer cell immunoglobulin-like receptor loci, several KIR2DS5 alleles predominate in African Americans.
The five two-domain stimulatory KIR genes carried by 100 random African Americans were characterized by DNA sequencing of genomic DNA covering the majority of coding exons. The frequency of individual loci was similar to that found in European Americans, with the exception of a reduced frequency for KIR2DS1 in African Americans. New alleles were identified at the KIR2DS1 (*008), KIR2DS2 (*006), KIR2DS3 (*00104, *00105, *00106, *004), KIR2DS4 (*00103, *00104, *009, *011, *012, *013), and KIR2DS5 (*006, *007, *00801, *00802, *009) loci. The distribution of alleles at each locus was similar to that found in a European American population except for KIR2DS5. KIR2DS5 exhibits a single allele in European Americans; the same allele is found at a reduced frequency (41% of gene-positive individuals), accompanied by KIR2DS5*006 (18%), KIR2DS5*007 (26%), and six other alleles (25%), in African Americans.
Departments of Pediatrics and Oncology, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, Washington, DC 20057, USA.
LiHua
L
Hou
Minghua
M
Chen
Bo
B
Jiang
Kanthi
K
Kariyawasam
Jennifer
J
Ng
Carolyn Katovich
CK
Hurley
D001741:Black or African American / Q000235:genetics*; D000483:Alleles; D004247:DNA / Q000032:analysis*; D004252:DNA Mutational Analysis; D005787:Gene Frequency; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology; D012675:Senegal; D014481:United States; D044465:White People / Q000235:genetics*
C496212:KIR2DS1 protein, human; C531595:KIR2DS5 protein, human; D054340:Receptors, KIR; D004247:DNA