A supramolecular approach for preparation of size-controlled nanoparticles.
A supramolecular approach has been developed for the preparation of supramolecular nanoparticles (SNPs) with variable sizes (30-450 nm) from three different molecular building blocks using a cyclodextrin/adamantane recognition system. Positron emission tomography (PET) was employed to study the biodistribution and lymph node drainage of the SNPs in mice. The sizes of the SNPs affect their in vivo characteristics (see picture).
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA.
Hao
H
Wang
Shutao
S
Wang
Helen
H
Su
Kuan-Ju
KJ
Chen
Amanda Lee
AL
Armijo
Wei-Yu
WY
Lin
Yanju
Y
Wang
Jing
J
Sun
Ken-ichiro
K
Kamei
Johannes
J
Czernin
Caius G
CG
Radu
Hsian-Rong
HR
Tseng
D000218:Adamantane / Q000737:chemistry; D000818:Animals; D003300:Copper / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry; D007553:Isotope Labeling; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D049268:Positron-Emission Tomography
D003505:Cyclodextrins; D003300:Copper; D000218:Adamantane