Allergy to carmine red (E120) is not dependent on concurrent mite allergy.
BACKGROUND
Positive skin prick test (SPT) reactions to carmine red (E120) have been reported to occur concurrently with reactions to mites. The relationships between positive SPT reactions to carmine, carmine allergy and concurrent mite reactions are unknown. The aim of this study was to analyse the prevalence of carmine sensitization and its clinical importance among patients with suspected allergy to food additives.


METHODS
The occurrence of positive SPT reactions to mites was studied in 6,464 patients: 3,164 were tested with carmine and 2,837 with shrimp. Carmine ingestion-associated symptoms were registered at the time of testing. Patients with positive SPT to carmine received a follow-up questionnaire on their symptoms 1-5 years later.


RESULTS
Positive SPT reactions to carmine were seen in 94 patients (3.0%) of whom 74% also had positive SPT reactions to mites and 22% to shrimp. Carmine ingestion-associated symptoms were not dependent on concurrent mite reactivity in 39/94 (42%) patients.


CONCLUSIONS
Carmine sensitization without sensitization to mites is seen in one fourth of the patients. Allergic reactions to carmine are not dependent on concurrent reactivity to mites.
Department of Dermatology, Turku University Hospital, Turku, Finland. jussi.liippo@utu.fi
Jussi
J
Liippo
Kaija
K
Lammintausta
D000485:Allergens / Q000276:immunology*; D000707:Anaphylaxis / Q000453:epidemiology; D000799:Angioedema / Q000453:epidemiology / Q000276:immunology; D000818:Animals; D002329:Carmine / Q000009:adverse effects*; D040001:Dermatophagoides farinae / Q000276:immunology; D040002:Dermatophagoides pteronyssinus / Q000276:immunology; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D005503:Food Additives / Q000009:adverse effects; D005512:Food Hypersensitivity / Q000209:etiology / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology*; D033561:Penaeidae / Q000276:immunology; D039981:Pyroglyphidae / Q000276:immunology*; D012882:Skin Tests; D011795:Surveys and Questionnaires; D014581:Urticaria / Q000453:epidemiology / Q000276:immunology
D000485:Allergens; D005503:Food Additives; D002329:Carmine