Smoking enhances risk for new external genital warts in men.
Repeat episodes of HPV-related external genital warts reflect recurring or new infections. No study before has been sufficiently powered to delineate how tobacco use, prior history of EGWs and HIV infection affect the risk for new EGWs. Behavioral, laboratory and examination data for 2,835 Multicenter AIDS Cohort Study participants examined at 21,519 semi-annual visits were evaluated. Fourteen percent (391/2835) of men reported or were diagnosed with EGWs at 3% (675/21,519) of study visits. Multivariate analyses showed smoking, prior episodes of EGWs, HIV infection and CD4+ T-lymphocyte count among the infected, each differentially influenced the risk for new EGWs.
Division of Primary Care, School of Nursing, University of California at Los Angeles (UCLA), Los Angeles, California, USA. dwiley@ucla.edu
Dorothy J
DJ
Wiley
David
D
Elashoff
Emmanuel V
EV
Masongsong
Diane M
DM
Harper
Karen H
KH
Gylys
Michael J
MJ
Silverberg
Robert L
RL
Cook
Lisette M
LM
Johnson-Hill
D001727:Bisexuality; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D003218:Condylomata Acuminata / Q000209:etiology*; D015658:HIV Infections / Q000150:complications; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*