Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States.
BACKGROUND
Previous studies have shown associations between dust exposure or lung burden and emphysema in coal miners, although the separate contributions of various predictors have not been clearly demonstrated.


OBJECTIVE
To quantitatively evaluate the relationship between cumulative exposure to respirable coal mine dust, cigarette smoking, and other factors on emphysema severity.


METHODS
The study group included 722 autopsied coal miners and nonminers in the United States. Data on work history, smoking, race, and age at death were obtained from medical records and questionnaire completed by next-of-kin. Emphysema was classified and graded using a standardized schema. Job-specific mean concentrations of respirable coal mine dust were matched with work histories to estimate cumulative exposure. Relationships between various metrics of dust exposure (including cumulative exposure and lung dust burden) and emphysema severity were investigated in weighted least squares regression models.


RESULTS
Emphysema severity was significantly elevated in coal miners compared with nonminers among ever- and never-smokers (P < 0.0001). Cumulative exposure to respirable coal mine dust or coal dust retained in the lungs were significant predictors of emphysema severity (P < 0.0001) after accounting for cigarette smoking, age at death, and race. The contributions of coal mine dust exposure and cigarette smoking were similar in predicting emphysema severity averaged over this cohort.


CONCLUSIONS
Coal dust exposure, cigarette smoking, age, and race are significant and additive predictors of emphysema severity in this study.
National Institute for Occupational Safety and Health, Education and Information Division, Risk Evaluation Branch, Cincinnati, Ohio 45226-1998, USA. ekuempel@cdc.gov
Eileen D
ED
Kuempel
Matthew W
MW
Wheeler
Randall J
RJ
Smith
Val
V
Vallyathan
Francis H Y
FH
Green
D000368:Aged; D001344:Autopsy; D003032:Coal Mining; D004391:Dust; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D011656:Pulmonary Emphysema / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects*; D015996:Survival Rate / Q000639:trends; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D014481:United States / Q000453:epidemiology
D004391:Dust; D014028:Tobacco Smoke Pollution