Severe acute pancreatitis: the life after.
BACKGROUND
The present study reports functional and morphological changes noted over long-term follow-up in patients with severe acute pancreatitis.


METHODS
Thirty patients who had completed at least 6 months after recovery were included. Fecal fat, urinary D-xylose, blood sugar, C-peptide, pancreatic changes, and recurrences were studied.


RESULTS
Etiology was gallstones (12), alcohol (10), both gallstone and alcohol (3), and idiopathic (5). Five patients were managed conservatively while 25 underwent surgery. Mean follow-up was 31.3 months. Exocrine and endocrine insufficiencies were noted in 12 (40%) and were more common in no-necrosis group compared to necrosis group (p = 0.04 and 0.28, respectively) and infected compared to sterile pancreatitis (45% vs. 25%, p = 0.55 and 50% vs. 12%, p = 0.15, respectively). Higher frequency was noted in nonvisualized, partly visualized, and dilated segment of duct. Significant proportion (8/12) had both exocrine and endocrine abnormalities and their incidence decreased as duration of follow-up increased. Urinary D-xylose excretion was abnormal in 16% and noted >1 year postrecovery. Thirty percent required >1 readmission and pain was the commonest cause.


CONCLUSIONS
Forty percent had functional abnormality; 16% had mucosal absorption abnormality while 30% required >1 readmission. Exocrine and endocrine insufficiencies were more prevalent in first year, and a significant proportion had both. A trend for higher functional insufficiency was observed in infected necrosis, complete or incomplete visualization of main pancreatic duct (MPD), dilated segment of MPD, and pseudocyst.
Surgical Gastroenterology Division, Department of General Surgery, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, India, 160012. rajsarakshi@yahoo.co.in
Rajesh
R
Gupta
Jai Dev
JD
Wig
Deepak Kumar
DK
Bhasin
Paramjit
P
Singh
Sudha
S
Suri
Mandeep
M
Kang
Surinder Singh
SS
Rana
Satyawati
S
Rana
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000378:metabolism; D016009:Chi-Square Distribution; D015331:Cohort Studies; D003131:Combined Modality Therapy; D010188:Exocrine Pancreatic Insufficiency / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007902:Length of Stay; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D010186:Pancreatic Function Tests; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D011336:Probability; D011446:Prospective Studies; D011788:Quality of Life; D012008:Recurrence; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D017741:Survivors; D013997:Time Factors; D014994:Xylose / Q000652:urine; D055815:Young Adult
D015415:Biomarkers; D001786:Blood Glucose; D002096:C-Peptide; D014994:Xylose