[Osteoclastogenesis and bone resorption].
Osteoclasts, the multinucleated cells that resorb bone, originate from monocyte-macrophage lineage cells. Various hormones, cytokines and growth factors are involved in osteoclastogenesis, via interaction with osteoblasts. Deficiency of osteoprotegerin (OPG), a soluble decoy receptor for receptor activator of NF-kappa B ligand (RANKL), in mice induces osteoporosis caused by enhanced bone resorption but also accelerates bone formation. OPG-deficient mice exhibite high serum alkaline phosphatase activity and osteocalcin concentration, both of which are decreased to the levels of wild-type mice by the bisphosphonate injection. This suggests that bone formation is coupled with bone resorption in vivo. RANKL expressed by osteoblasts is a requirement for osteoclastogenesis, osteoblasts also play important roles in osteoclastogenesis through offering the critical microenvironment for the action of RANKL.
Nakamura
Midori
M
Department of Biochemistry, Matsumoto Dental University.
Nakamichi
Yuko
Y
Nakamura
Hiroshi
H
Udagawa
Nobuyuki
N
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D001862:Bone Resorption / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics* / Q000502:physiology; D004164:Diphosphonates / Q000494:pharmacology; D006801:Humans; D051379:Mice; D010006:Osteoblasts / Q000502:physiology; D015675:Osteocalcin / Q000097:blood; D010010:Osteoclasts / Q000166:cytology*; D010012:Osteogenesis / Q000502:physiology; D010024:Osteoporosis / Q000209:etiology; D053244:Osteoprotegerin / Q000172:deficiency; D053245:RANK Ligand / Q000096:biosynthesis / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014807:Vitamin D / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D004164:Diphosphonates; D053244:Osteoprotegerin; D053245:RANK Ligand; C505689:Tnfsf11 protein, mouse; D015675:Osteocalcin; D014807:Vitamin D; D000469:Alkaline Phosphatase