The neurofibroma cell of origin: SKPs expand the playing field.
Mounting evidence suggests that stem/progenitor cells may be the cells of origin for many tumor types. In this issue of Cell Stem Cell, Le et al. (2009) demonstrate that skin-derived precursors (SKPs) can initiate dermal neurofibromas and highlight the importance of the microenvironment in the formation of this complex tumor.
Morris
Zachary S
ZS
Massachusetts General Hospital Center for Cancer Research and Department of Pathology, Harvard Medical School, Charlestown, MA 02129, USA.
McClatchey
Andrea I
AI
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D051379:Mice; D009455:Neurofibroma / Q000378:metabolism*; D025542:Neurofibromin 1 / Q000378:metabolism; D012867:Skin / Q000166:cytology / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
D025542:Neurofibromin 1