Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis.
Simplify, simplify, simplify! Pretubulysin (structure without the green substituents), a simplified tubulysin was prepared in the laboratory and also found in a natural myxobacterial source. This biosynthetic precursor of the tubulysins is not as active as tubulysins A and D but is still effective in picomolar concentrations against cancer cell lines.
Ullrich
Angelika
A
Institut für Organische Chemie, Universität des Saarlandes, Postfach 151150, 66041 Saarbrücken, Germany.
Chai
Yi
Y
Pistorius
Dominik
D
Elnakady
Yasser A
YA
Herrmann
Jennifer E
JE
Weissman
Kira J
KJ
Kazmaier
Uli
U
Müller
Rolf
R
D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009231:Myxococcales / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry; D011498:Protein Precursors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D009842:Oligopeptides; D011355:Prodrugs; D011498:Protein Precursors