The neurofibroma cell of origin: SKPs expand the playing field.
Mounting evidence suggests that stem/progenitor cells may be the cells of origin for many tumor types. In this issue of Cell Stem Cell, Le et al. (2009) demonstrate that skin-derived precursors (SKPs) can initiate dermal neurofibromas and highlight the importance of the microenvironment in the formation of this complex tumor.
Massachusetts General Hospital Center for Cancer Research and Department of Pathology, Harvard Medical School, Charlestown, MA 02129, USA.
Zachary S
ZS
Morris
Andrea I
AI
McClatchey
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D051379:Mice; D009455:Neurofibroma / Q000378:metabolism*; D025542:Neurofibromin 1 / Q000378:metabolism; D012867:Skin / Q000166:cytology / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
D025542:Neurofibromin 1