Association of metabolic syndrome with insulin-like growth factors among adults in the US.
OBJECTIVE
To examine the association of insulin-like growth factors (IGFs) with metabolic syndrome in a nationally representative sample.


METHODS
We used data from the Third National Health and Nutrition Examination Survey. Analysis is based on participants who provided a fasting blood sample and were aged 20 years and older (n = 5,903). Participants were classified by a number of risk factors for metabolic syndrome and stratified by diabetes status.


RESULTS
Each of the components of metabolic syndrome (increased waist circumference, higher triglycerides, lower HDL cholesterol, higher blood pressure, higher fasting glucose and diabetes) was each associated with lower levels of IGF-I, IGF-BP3 and the Ratio IGF-I/IGF-BP3. Each of the metabolic syndrome components was also associated with higher levels of insulin. Participants with 3-5 components of metabolic syndrome had significantly lower IGF-I and higher IGF-BP3 levels compared to adults with 1-2 components or 0 components, after adjustment for potential confounders. Participants with diabetes had lower levels of IGF-I and IGF-BP3, and higher levels of insulin, regardless of the number of metabolic syndrome components.


CONCLUSIONS
These findings may prove useful to an understanding of the role of IGF-I in human disease, in particular its relation to metabolic syndrome, diabetes and potentially some cancers.
Saydah
Sharon
S
Division of Diabetes Translation, Center for Disease Control and Prevention, 3311 Toledo Rd, Hyattsville, MD 20782, USA. ssaydah@cdc.gov
Ballard-Barbash
Rachel
R
Potischman
Nancy
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D048909:Diabetes Complications / Q000097:blood / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000453:epidemiology* / Q000209:etiology*; D008875:Middle Aged; D013002:Somatomedins / Q000032:analysis*; D014481:United States / Q000453:epidemiology; D055815:Young Adult
D007328:Insulin; D013002:Somatomedins