Two base pair duplexes suffice to build a novel material.
Tetrahedral DNA hybrids with tetrakis(p-hydroxyphenyl)methane cores hybridize in a sequence-specific fashion at much higher temperatures than isolated linear duplexes. Dinucleotide DNA arms suffice to induce the formation of a solid at room temperature; this demonstrates the strength of multivalent binding. The graphic shows a view of a modeled assembly.
Meng
Martin
M
Institut für Organische Chemie and Center for functional Nanostructures, Universität Karlsruhe (TH), 76131 Karlsruhe, Germany.
Ahlborn
Carolin
C
Bauer
Matthias
M
Plietzsch
Oliver
O
Soomro
Shahid A
SA
Singh
Arunoday
A
Muller
Thierry
T
Wenzel
Wolfgang
W
Bräse
Stefan
S
Richert
Clemens
C
D020029:Base Pairing; D001593:Benzyl Compounds / Q000737:chemistry*; D003460:Crystallization; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D044366:Transition Temperature
D001593:Benzyl Compounds; D005456:Fluorescent Dyes; D009841:Oligonucleotides; C542267:tetrakis(p-hydroxyphenyl)methane; D004247:DNA