Necrosis caused by intra-arterial injection of promethazine: case report.
Promethazine injections have led to necrosis and gangrene of the distal upper extremity when inadvertently injected into an artery. There have been few case reports of this alarming complication in the literature. We report on 2 cases of intra-arterial promethazine injection that led to amputation.
Mercer University School of Medicine and OrthoGeorgia, Macon, Georgia 31201, USA. andrewforet@yahoo.com
Andrew Lee
AL
Foret
Andrew P
AP
Bozeman
Waldo E
WE
Floyd
D000328:Adult; D000671:Amputation, Surgical; D000792:Angiography; D001132:Arm / Q000098:blood supply* / Q000473:pathology*; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D005260:Female; D005385:Fingers / Q000098:blood supply* / Q000473:pathology*; D006225:Hand / Q000098:blood supply* / Q000473:pathology*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000633:toxicity*; D006801:Humans; D007270:Injections, Intra-Articular / Q000009:adverse effects*; D007511:Ischemia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008508:Medication Errors; D009336:Necrosis; D011398:Promethazine / Q000008:administration & dosage / Q000633:toxicity*; D017534:Radial Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D017535:Ulnar Artery / Q000000981:diagnostic imaging / Q000187:drug effects*
D006634:Histamine H1 Antagonists; D011398:Promethazine