The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients.
We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins (HSPA1A, HSPA1B and HSPA1L) and found a significant association between one HSPA1B variation and schizophrenia (SZ). We now report an association between a set of variations (rs2227956, rs2075799, rs1043618, rs562047 and rs539689) within the same genes and a larger sample of schizophrenic inpatients. A single variation, rs539689 (HSPA1B), was found to be marginally associated with Positive and Negative Syndrome Scale (PANSS) positive scores at discharge, and haplotype analysis revealed a significant association between improvement in PANSS scores with both A-C-G-G and A-C-G-G haplotypes. These findings further support a role of heat shock proteins in the pathophysiology of SZ.
Pae
Chi-Un
CU
Department of Psychiatry, Holy Family Hospital, Catholic University of Korea College of Medicine, Wonmi-Gu, Bucheon, Republic of Korea. pae@catholic.ac.kr
Drago
Antonio
A
Kim
Jung-Jin
JJ
Mandelli
Laura
L
De Ronchi
Diana
D
Serretti
Alessandro
A
D000328:Adult; D017668:Age of Onset; D000704:Analysis of Variance; D004252:DNA Mutational Analysis; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006239:Haplotypes; D006760:Hospitalization; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D015999:Multivariate Analysis; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics*
D018840:HSP70 Heat-Shock Proteins; C490786:HSPA1A protein, human; C525621:HSPA1B protein, human; C543454:HSPA1L protein, human