Microdialysis of paraspinal muscle in healthy volunteers and patients underwent posterior lumbar fusion surgery.
Paraspinal muscle damage is inevitable during conventional posterior lumbar fusion surgery. Minimal invasive surgery is postulated to result in less muscle damage and better outcome. The aim of this study was to monitor metabolic changes of the paraspinal muscle and to evaluate paraspinal muscle damage during surgery using microdialysis (MD). The basic interstitial metabolisms of the paraspinal muscle and the deltoid muscle were monitored using the MD technique in eight patients, who underwent posterior lumbar fusion surgery (six male and two female, median age 57.7 years, range 37-74) and eight healthy individuals for different positions (five male and three female, age 24.1 +/- 0.8 years). Concentrations of glucose, glycerol, and lactate pyruvate ratio (L/P) in both tissues were compared. In the healthy group, the glucose and glycerol concentrations and L/P were unchanged in the paraspinal muscle when the body position changed from prone to supine. The glucose concentration and L/P were stable in the paraspinal muscle during the surgery. Glycerol concentrations increased significantly to 243.0 +/- 144.1 microM in the paraspinal muscle and 118.9 +/- 79.8 microM in the deltoid muscle in the surgery group. Mean glycerol concentration difference (GCD) between the paraspinal muscle and the deltoid tissue was 124.1 microM (P = 0.003, with 95% confidence interval 83.4-164.9 microM). The key metabolism of paraspinal muscle can be monitored by MD during the conventional posterior lumbar fusion surgery. The glycerol concentration in the paraspinal muscle is markedly increased compared with the deltoid muscle during the surgery. It is proposed that GCD can be used to evaluate surgery related paraspinal muscle damage. Changing body position did not affect the paraspinal muscle metabolism in the healthy subjects.
Aarhus University Aalborg Hospital, Aalborg, Denmark. gar@rn.dk
Gang
G
Ren
Søren
S
Eiskjaer
Jon
J
Kaspersen
Finn Bjarke
FB
Christensen
Sten
S
Rasmussen
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D011187:Posture; D019289:Pyruvic Acid / Q000378:metabolism; D013123:Spinal Fusion; D055815:Young Adult
D019344:Lactic Acid; D019289:Pyruvic Acid; D005947:Glucose; D005990:Glycerol