Development and characterization of mucoadhesive buccal patches of salbutamol sulphate.
Mucoadhesive patch releasing the drug in the oral cavity at predetermined rate may present distinct advantages over traditional dosage forms such as tablets, gels and solutions. The present study was concerned with the preparation and evaluation of mucoadhesive buccal patches for the controlled systemic delivery of Salbutamol sulphate to avoid first pass hepatic metabolism. The developed patches were evaluated for the physicochemical, mechanical and drug release characteristics. The patches showed desired mechanical and physicochemical properties to withstand environment of oral cavity. The in-vitro release study showed that patches could deliver drug to the oral mucosa for a period of 7 h. the patches exhibited adequate stability when tested under accelerated conditions.
Prin. K. M. Kundanani College of Pharmacy, Jotejoy building, Cuffe Parade, Colaba, Mumbai-400 005, India. rajesh12feb@yahoo.co.in
Rajesh Singh
RS
Patel
S S
SS
Poddar
D000268:Adhesiveness; D000420:Albuterol / Q000008:administration & dosage* / Q000737:chemistry; D000818:Animals; D002610:Cheek; D016503:Drug Delivery Systems; D009061:Mouth Mucosa / Q000378:metabolism*; D011817:Rabbits
D000420:Albuterol