New Genetic Lineage of Tula Hantavirus in Microtus arvalis obscurus in Eastern Kazakhstan.
Genomic sequences of Tula (TULV) hantavirus were recovered from tissue samples of European common voles Microtus arvalis (subspecies obscurus) captured in Kazakhstan, Central Asia. Phylogenetic analysis of the S genomic segment of Kazakh TULV strains showed that they form distinct, well supported genetic lineage and share a more ancient common ancestor with two Russian lineages of TULV. The deduced sequence of the nucleocapsid (N) protein of Kazakh TULV strains carried specific amino acid signature: T274Q276T281. The Microtus arvalis group includes several sibling species and/or subspecies in Eurasia, indicating recent and ongoing evolutionary radiation. Our data on TULV lineages in Central Asia, the region not studied for hantaviruses earlier, highlight the diversity of both Microtus host and the virus and also their co-evolution.
Department of Virology, Haartman Institute, University of Helsinki, Finland.
Angelina
A
Plyusnina
Juha
J
Laakkonen
Jukka
J
Niemimaa
Heikki
H
Henttonen
Alexander
A
Plyusnin