Very late relapses in glioblastoma long-term survivors.
Long-term survival of patients with histologically confirmed glioblastoma is a rare event with figures in the range of 2-3% for 5-year survival (Scott et al. in Ann Neurol 46:183-188, 1999; McLendon and Halperin in Cancer 98:1745-1748, 2003; Krex et al. in Brain 130:2596-2606, 2007). Prognosis and further clinical course of these patients beyond 5 years after diagnosis are in essence unknown with only anecdotal reports of patients surviving for 10 years or more (Salvati et al. J Neurooncol 36:61-64, 1998). We here report on the extended follow-up (mean, 139.4 months) of a cohort of glioblastoma long-term survivors. Very late relapses occurred in many patients even after more than 10 years of progression-free survival.
Oliver
O
Bähr
Ulrich
U
Herrlinger
Michael
M
Weller
Joachim P
JP
Steinbach
D000328:Adult; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000628:therapy; D017741:Survivors; D013997:Time Factors