Aureobasidin, new antifouling metabolite from marine-derived fungus Aureobasidium sp.
Two antifouling compounds, aureobasidin (1), a new ester with an unusual 4,6-dihydroxydecanoic acid residue, and (3R,5S)-3,5-dihydroxydecanoic acid (2), were isolated from the marine-derived fungus Aureobasidium sp., in addition to (5R,3Z)-5-hydroxydec-3-enoic acid (3) and (R)-3-hydroxydecanoic acid (4). The structures were unambiguously established by IR, 1D and 2D NMR spectroscopic and mass spectral data. Compounds 1-3 were found to be active against Bacillus subtilis, Escherichia coli and Staphyllococcus aureus. Compound 3 showed fungistatic activity against Candida albicans.
Department ofPharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Ahmed
A
Abdel-Lateff
Ehab S
ES
Elkhayat
Mostafa A
MA
Fouad
Tatsufumi
T
Okino
D001203:Ascomycota / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003652:Decanoic Acids / Q000032:analysis* / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D004952:Esters / Q000032:analysis* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects
D003652:Decanoic Acids; D004952:Esters