Lon protease is essential for paradoxical survival of Escherichia coli exposed to high concentrations of quinolone.
A deficiency of the Escherichia coli Lon protease blocked paradoxical survival occurring at very high nalidixic acid concentrations. The absence of Lon also blocked a parallel increase in cell lysate viscosity likely to reflect DNA size. Thus, Lon may participate in repairing quinolone-mediated DNA lesions formed at high drug concentrations.
Public Health Research Institute, New Jersey Medical School, UMDNJ, 225 Warren Street, Newark, NJ 07103, USA.
Muhammad
M
Malik
Joseph
J
Capecci
Karl
K
Drlica
D000890:Anti-Infective Agents / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D009268:Nalidixic Acid / Q000494:pharmacology; D049070:Protease La / Q000235:genetics / Q000502:physiology*; D015363:Quinolones / Q000494:pharmacology*
D000890:Anti-Infective Agents; D029968:Escherichia coli Proteins; D015363:Quinolones; D009268:Nalidixic Acid; D002701:Chloramphenicol; D049070:Protease La