Happiness and stress alter susceptibility to cardiac events in Long QT Syndrome.
OBJECTIVE
We sought to determine whether the circumstances preceding an arrhythmic event differed from those preceding a prior control occasion in patients with Long QT Syndrome (LQTS), a well-characterized genetic disorder that puts affected individuals at risk for sudden cardiac death.


METHODS
Thirty-eight patients (89% female) with LQTS completed a "case-crossover interview" in which each patient served as his/her own control by reporting on circumstances preceding an arrhythmic event (syncope, aborted cardiac arrest, or defibrillator discharge) and preceding a control occasion (the next-to-last birthday). On average the interview was conducted 17 months after the cardiac event and control occasion.


RESULTS
During the 24-hour period preceding the cardiac event compared to the day before the control occasion, psychological stress was elevated, peak happiness was reduced, and peak exertion was not significantly different. Rated for the 6-month intervals preceding the event and control occasions, none of these three variables was significantly associated with events.


CONCLUSIONS
Happiness is associated with a reduction in the 24-hour risk of cardiac events in patients with LQTS, with stress having an opposite effect. To our knowledge, this is the first report indicating that positive emotion may have a protective effect on life-threatening ventricular arrhythmias. This study lends further support to the role of emotions in influencing cardiac events in arrhythmia-prone patients.
Lane
Richard D
RD
Department of Psychiatry, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724-5002, USA. lane@email.arizona.edu
Reis
Harry T
HT
Peterson
Derick R
DR
Zareba
Wojciech
W
Moss
Arthur J
AJ
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control; D016022:Case-Control Studies; D015984:Causality; D015897:Comorbidity; D018592:Cross-Over Studies; D016757:Death, Sudden, Cardiac / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006240:Happiness; D006801:Humans; D007407:Interviews as Topic; D008133:Long QT Syndrome / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D013315:Stress, Psychological / Q000453:epidemiology* / Q000503:physiopathology; D014481:United States / Q000453:epidemiology