Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau.
We report the possible transmission of drug-resistant human immunodeficiency virus type 2. A 66-year-old woman from rural Guinea Bissau who had no obvious antiretroviral exposure was found to harbor a variant with the multidrug-resistance mutation Q151M. Finding this mutation among a drug-naive population presents an important public health issue that needs to be addressed for treatment to be effective.
Jallow
Sabelle
S
Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, The Gambia. sjallow@mrc.gm
Vincent
Tim
T
Leligdowicz
Aleksandra
A
De Silva
Thushan
T
Van Tienen
Carla
C
Alabi
Abraham
A
Sarge-Njie
Ramu
R
Aaby
Peter
P
Corrah
Tumani
T
Whittle
Hilton
H
Jaye
Assan
A
Vanham
Guido
G
Rowland-Jones
Sarah
S
Janssens
Wouter
W
D000368:Aged; D019943:Amino Acid Substitution / Q000235:genetics; D019380:Anti-HIV Agents / Q000627:therapeutic use; D024921:Drug Resistance, Multiple, Viral; D005260:Female; D006169:Guinea-Bissau; D015658:HIV Infections / Q000635:transmission / Q000821:virology*; D015498:HIV-2 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D017422:Sequence Analysis, DNA
D019380:Anti-HIV Agents