Neurolymphomatosis mimicking chemotherapy-induced ototoxicity.
OBJECTIVE
To present an unusual cause of bilateral sensorineural hearing loss mimicking chemotherapy-induced ototoxicity.


METHODS
A 76-year-old woman with bilateral sudden sensorineural hearing loss after chemotherapy for non-Hodgkin lymphoma was referred for cochlear implantation.


METHODS
Prednisone and acyclovir were administered empirically during the course of the diagnostic evaluation.


METHODS
Diagnostic tests were obtained, including audiometry, positron emission tomography/computed tomographic imaging, and magnetic resonance imaging scan of the brain with gadolinium.


RESULTS
Audiometry revealed bilateral profound sensorineural hearing loss without improvement after steroid and acyclovir treatment. Postchemotherapy positron emission tomography/computed tomographic imaging obtained 1 week after onset of hearing loss suggested the lymphoma to be in remission. However, magnetic resonance imaging obtained a few weeks later, concurrent with progression of symptoms to include facial palsy and numbness, demonstrated enhancement and thickening of multiple cranial nerves, consistent with neurolymphomatosis (malignant lymphocytic infiltration of nerves).


CONCLUSIONS
Particular vigilance must be given to the potential for malignant invasion of the peripheral nervous system in the context of new-onset sensorineural hearing loss after chemotherapy. Such a neurologic deficit should not be assumed to be chemotherapy induced even if the hearing loss is bilaterally symmetric and the only neurologic abnormality.
Hong
Robert S
RS
Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA. Robert-hong@uiowa.edu
Woodson
Erika A
EA
Hansen
Marlan R
MR
D000212:Acyclovir / Q000627:therapeutic use; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use; D001299:Audiometry; D003391:Cranial Nerves / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006312:Hearing Loss, Bilateral / Q000139:chemically induced* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis / Q000556:secondary; D011241:Prednisone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011241:Prednisone; D000212:Acyclovir