Molecular rods with oligospiroketal backbones as anchors in biological membranes.
Getting stuck in: A hydrophobic molecular rod with terminal fluorescent moieties has been synthesized. The insertion of the rod into membranes was investigated and shown to incorporate efficiently into model and biological membranes (see picture; gray C, blue N, red O). Those rods can be used as stable membrane-associated anchors for functionalization of membrane surfaces.
Institut für Biologie, Humboldt-Universität zu Berlin, Invalidenstrasse 42, 10115 Berlin, Germany.
Peter
P
Müller
Jörg
J
Nikolaus
Sabine
S
Schiller
Andreas
A
Herrmann
Kristian
K
Möllnitz
Sylvia
S
Czapla
Pablo
P
Wessig
D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D010455:Peptides / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry*
D005456:Fluorescent Dyes; D005663:Furans; D010455:Peptides; D013141:Spiro Compounds; C520774:spiroketal