Advanced cancer of the ovary: intraperitoneal chemotherapy as a new therapeutical option.
Intraperitoneal (IP) chemotherapy has been used in patients presenting different stages of ovarian cancer. We performed a critical review of the available literature on IP as first-line treatment in advanced ovarian cancer to consider if this new option should be incorporated into the commonly applied guidelines for treatment of ovarian cancer. We concluded that without further data, it would not be ethically correct to administer chemotherapy intraperitoneally. Outside of planned clinical trials, patients should not be exposed to this treatment modality and its associated toxicity. The present international guidelines are still valid and recommended chemotherapy in advanced ovarian cancer remains treatment with paclitaxel and carboplatin. Further studies on this topic are, however, warranted.
Department of Oncology, San Giuseppe Hospital, via Giovanni Boccaccio 18, 50053, Empoli, Florence, Italy. oncologiaempoli@usl11.toscana.it
Giammaria
G
Fiorentini
Marco
M
Filippeschi
Gina
G
Turrisi
Andrea
A
Mambrini
Pier Giorgio
PG
Giannessi
Michelina
M
D'Alessandro
Susanna
S
Rossi
Patrizia
P
Dentico
Stefano
S
Guadagni
Maurizio
M
Cantore
Andrea
A
Madrigali
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000633:toxicity; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D018450:Disease Progression; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral / Q000379:methods*; D008495:Medical Oncology / Q000379:methods / Q000639:trends; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
D000970:Antineoplastic Agents