5-Hydroxymethyl-oxazolidin-2-one antibacterials. Actelion Pharmaceuticals: WO2008062379.
The application, WO2008062379, claims chimeric compounds comprising chemically linked 5-hydroxymethyl-oxazolidinone and tetracyclic-quinolone moieties. The claimed compounds are potent expanded-range antibacterial agents against selected gram-positive and gram-negative bacteria, which may exhibit dual mode of action as inhibitors of topoisomarases IV and protein synthesis. The structures of the compounds suggest that the linkers are chemically and biochemically stable. This application represents part of recently initiated research efforts at Actelion.
Kuwait University, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, P.O. Box 24923, Safat 13110, Kuwait. dphillips@hsc.edu.kw
Oludotun A
OA
Phillips
Leyla H
LH
Sharaf
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D027101:DNA Topoisomerase IV / Q000037:antagonists & inhibitors; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D023303:Oxazolidinones / Q000737:chemistry / Q000494:pharmacology*; D010330:Patents as Topic; D015363:Quinolones / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D023303:Oxazolidinones; D015363:Quinolones; D027101:DNA Topoisomerase IV