Vindesine-induced neuropathy mimicking Guillain-Barré syndrome.
A 13-year-old girl with acute lymphoblastic leukaemia, who was being treated with chemotherapy (including vindesine), developed paraplegia without paresthesia, which mimic Guillain-Barré syndrome. Spinal fluid analysis showed a normal protein level, vindesine neuropathy seemed to be the cause of the patient's neurological symptoms. The patient seemed to benefit from human normal immunoglobulin therapy and recovered 4 weeks later.
Department of Hematology, The Second Affiliated Hospital of General Hospital of PLA, Beijing 100091, China. lillyliu@peoplemail.com.cn
Lihui
L
Liu
Bing
B
Shi
Liping
L
Ye
Jiangang
J
Jin
Yuzhu
Y
Zhang
Wenqing
W
Hu
Mingjuan
M
Liu
Guojian
G
Li
D000293:Adolescent; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis*; D006801:Humans; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D014751:Vindesine / Q000009:adverse effects*
D000972:Antineoplastic Agents, Phytogenic; D014751:Vindesine