[About genetic determinants of aging pathways].
Aging of organism is a complex process, however it is succeeded to mark out of new evolution-conservative genetic component of longevity and aging. Among the most perspective problems, connecting with this component, there are search of longevity genes in model animals, investigations of mechanisms of environment influence on aging speed (meal quality, light and temperature regimes, irradiation and hypergravity), revealing of aging biomarkers and genes, determined exceptional centenarians in human, and non-genetics methods of aging correction. The most impressive results observed in gerontogene search. In yeast and nematodes there are mutations, which increase maximum lifespan on 10 times, in Drosophila and mice--about 2 times. Nevertheless, genes regulated the aging speed by indirection, controlling organism resistance to damages by exogenous and endogenous stresses.
Moskalev
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D000375:Aging / Q000235:genetics* / Q000502:physiology; D000818:Animals; D005075:Biological Evolution; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology; D014644:Genetic Variation; D006801:Humans; D008136:Longevity / Q000235:genetics* / Q000502:physiology