The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats: is the phospholamban-SERCA axis a therapeutic target?
Sepsis-induced myocardial dysfunction has traditionally been thought of as principally affecting systolic heart function. One of the primary reasons for this concept is that systolic dysfunction is relatively easy to conceptualize, visualize, and measure. With the advent of preload-independent measurements for diastolic function, both measurement and conceptual difficulties are being resolved, and a new realm of evidence is beginning to emerge regarding the aberrations that are found during cardiac relaxation in sepsis. A recent article in Critical Care brings this issue into sharper focus.
Heitner
Stephen B
SB
Division of Cardiology, Cooper University Hospital, 3 Cooper Plaza, Camden, NJ 08103, USA.
Hollenberg
Steven M
SM
D000818:Animals; D002135:Calcium-Binding Proteins / Q000187:drug effects / Q000502:physiology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006333:Heart Failure / Q000139:chemically induced / Q000503:physiopathology; D008070:Lipopolysaccharides / Q000633:toxicity*; D051381:Rats; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000187:drug effects / Q000502:physiology*; D018805:Sepsis / Q000150:complications; D000099211:Phospholamban
D002135:Calcium-Binding Proteins; D008070:Lipopolysaccharides; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000099211:Phospholamban