Sequence selective dual-emission detection of (i, i + 1) bis-phosphorylated peptide using diazastilbene-type Zn(II)-Dpa chemosensor.
This paper describes a new fluorescent chemosensor for phosphorylated peptide, which comprises a rigid trans-4,4'-diazastilbene and two Zn(II)-Dpa (2,2'-dipicolylamine) units; this chemosensor sequence-selectively binds to a (i, i + 1) bis-phosphorylated peptide and displays a dual-emission fluorescence change.
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto, Japan.
Yoshiyuki
Y
Ishida
Masa-aki
MA
Inoue
Tomonori
T
Inoue
Akio
A
Ojida
Itaru
I
Hamachi
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D010848:Picolinic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D017186:Titrimetry
C501847:2,2'-dipicolylamine; D000588:Amines; D005456:Fluorescent Dyes; D010455:Peptides; D010848:Picolinic Acids; D011725:Pyridines