Functionalized templates for the convergent assembly of polyethers: synthesis of the HIJK rings of gymnocin A.
Extension ladder: The successful application of epoxide-opening strategies towards the synthesis of ladder-type polyethers is contingent upon further elaboration of the product. By employing two different functionalized templates, a fragment of gymnocin A that bears four sites for subsequent fragment coupling has been prepared (see scheme; Bn = benzyl).
Van Dyke
Aaron R
AR
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Rm 18-492, USA.
Jamison
Timothy F
TF
D003500:Cyclization; D004987:Ethers / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*
D004987:Ethers; D004988:Ethers, Cyclic; C458159:gymnocin A