Role of relaxin in maternal systemic and renal vascular adaptations during gestation.
In this paper, the hemodynamic changes of normal pregnancy are reviewed and the underlying hormonal and molecular mechanisms are discussed. Among other findings related to these phenomena, our previous work has demonstrated the importance of relaxin in systemic and renal vascular as well as osmoregulatory changes during gestation. These findings are summarized, and new concepts related to the function of relaxin in blood vessels are presented. Finally, work in progress is briefly outlined.
McGuane
Jonathan T
JT
Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610, USA.
Debrah
Julianna E
JE
Debrah
Dan O
DO
Rubin
J Peter
JP
Segal
Mark
M
Shroff
Sanjeev G
SG
Conrad
Kirk P
KP
D000818:Animals; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D020782:Matrix Metalloproteinases / Q000378:metabolism; D011247:Pregnancy; D012065:Relaxin / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D012065:Relaxin; D020782:Matrix Metalloproteinases