[Larval stages of Ascaris lumbricoides: hyaluronan-binding capacity].
Hyaluronic acid has important functions in inflammatory and tissue reparation processes. Owing to the varied strategies of the parasites to evade the host's immune response, as well as the multiple functions and physiological importance of hyaluronic acid, the aim was to study the hyaluronan binding capacity by Ascaris lumbricoides larval stages. Larval concentrates were prepared by hatching A. lumbricoides eggs. The larvae were collected by the Baermann method. The test of serum soluble CD44 detection by Agregation Inhibition was modified. All the larval concentrates presented hyaluronan binding capacity. The obtained results allow to suppose the existence of an hyaluronic acid specific receptor in A. lumbricoides. This receptor eventually might compete with the usual receptors of the host. The parasite might use this mechanism to evade the immune response.
Cátedra de Parasitología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. tefu1958@hotmail.com
Patricia
P
Ponce-León
Patricia
P
Foresto
Juana
J
Valverde
D000818:Animals; D017164:Ascaris lumbricoides / Q000254:growth & development* / Q000276:immunology / Q000378:metabolism; D002465:Cell Movement; D004903:Erythrocyte Aggregation; D015801:Helminth Proteins / Q000378:metabolism*; D006790:Host-Parasite Interactions; D006801:Humans; D018960:Hyaluronan Receptors / Q000097:blood / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000378:metabolism*; D007814:Larva; D011485:Protein Binding
C497483:CD44 protein, human; D015801:Helminth Proteins; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid