[Ultraviolet radiation, tobacco smoke and estrogens pathways of influence on skin aging; capabilities of prevention].
Aging refers to the hole human body including the skin, but here it is usually better seen by milieu, repeatedly burdens life quality. There are many theories explaining the process of human aging, but its reasons, irrespectively of their criteria, are numerous and affect one another. Skin aging just like the entire body depends on the influence of genetics, environmental and hormonal factors. Ultraviolet radiation and tobacco smoking have confirmed influence on skin aging. The role of hormonal disorders, particularly estrogens are also underlined. Mechanisms of skin aging induced by UV radiation, tobacco smoke and estrogens are similar and included unfavourable effects of oxidative stress (free radicals) and also disturbances of the TGF beta pathway. Data of many clinical studies proved that avoiding sun and smoking, nucleic acids diet, antioxidant supplementation, everyday use of UV filter, moisturizers, topical use of antioxidants, retinoid derivatives and flavonoids have proved protective the influence to multidirectional process of skin aging.
Katedra i Klinika Dermatologii CM UJ w Krakowie. wojaspelca@su.krakow.pl
Anna
A
Wojas-Pelc
Joanna
J
Sułowicz
Magdalena
M
Nastałek
D000975:Antioxidants / Q000494:pharmacology; D004781:Environmental Exposure / Q000009:adverse effects* / Q000517:prevention & control; D004967:Estrogens / Q000009:adverse effects*; D006801:Humans; D018384:Oxidative Stress; D011322:Primary Prevention / Q000379:methods*; D011788:Quality of Life; D012176:Retinoids / Q000494:pharmacology; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects*; D012907:Smoking / Q000009:adverse effects; D000074606:Smoking Prevention; D014028:Tobacco Smoke Pollution / Q000009:adverse effects* / Q000517:prevention & control; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000975:Antioxidants; D004967:Estrogens; D012176:Retinoids; D014028:Tobacco Smoke Pollution