Pleiotrophin and peripheral nerve injury.
The proto-oncogene pleiotrophin, discovered in 1989, was considered as a multifunctional growth factor, which played an important role in tumor occurrence, development, and central nervous system. The latest research showed that pleiotrophin signal pathway probably participated in neural repair after peripheral nerve injury, especially in the following critical points, such as the protection of spinal cord neuron, the promotion of the speed of neuron axon regeneration, the guidance of neuron axon regeneration, skeleton muscle reinnervation, and so on. It potentially plays a key role in the guidance of neural axon regeneration in peripheral nervous system and muscle reinnervation. With the deepening of related researches, pleiotrophin gene would become a controllable target for improving the repairing effect of peripheral nerve injury and reconstruction of the neuromuscular junction.
Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Sciences & Technology, Jiefang Ave 1277, Wuhan 430022, People's Republic of China. lijin1973@hotmail.com
Li
L
Jin
Chen
C
Jianghai
Liu
L
Juan
Kang
K
Hao
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D002470:Cell Survival / Q000235:genetics / Q000502:physiology; D016207:Cytokines / Q000235:genetics / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009416:Nerve Regeneration / Q000235:genetics / Q000502:physiology; D009474:Neurons / Q000473:pathology; D059348:Peripheral Nerve Injuries; D000090063:Proto-Oncogene Mas; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D002352:Carrier Proteins; D016207:Cytokines; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; C066845:pleiotrophin