Outcomes for subsequent pregnancy in women who have undergone misoprostol mid-trimester termination of pregnancy.
In Australia, the most common method of mid-trimester termination of pregnancy (TOP) is by medical induction with the prostaglandin E 1 analog misoprostol. This study was undertaken to compare the pregnancy outcomes of women who had undergone a misoprostol mid-trimester TOP in their last pregnancy with those of a similar cohort of women without a history of misoprostol TOP. This study suggests a possibility that medical mid-trimester TOP with misoprostol increases the risk of preterm or very preterm delivery in a subsequent pregnancy but larger studies are needed to confirm or dismiss this.
Mirmilstein
Vadim
V
Department of Obstetrics and Gynaecology, Royal Women's Hospital, Melbourne, Victoria, Australia. dimam@tpg.com.au
Rowlands
Shelley
S
King
James F
JF
D000020:Abortifacient Agents, Nonsteroidal / Q000009:adverse effects*; D000028:Abortion, Induced / Q000009:adverse effects*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000009:adverse effects*; D010865:Pilot Projects; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D047928:Premature Birth / Q000209:etiology*; D012307:Risk Factors; D002581:Uterine Cervical Incompetence / Q000209:etiology*
D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol