[Antiulcer effect of calcium pectate on model of chronic gastric ulcer in rats].
Calcium pectate has been found to exhibit an antiulcer activity in rats with model of chronic ulcers. Course treatment of the experimental animals with calcium pectate (i) accelerated the repair of experimental damage due to better integrity and higher secretory activity of epithelium and (ii) decreased hemodynamic disorders in surrounding mucous and epithelial membranes. The maximum effect, which was achieved with calcium pectate in a dose of 50 mg/kg, exceeded the action of the reference drug maalox on both 14th and 21st days of experiment.
Krylova
S G
SG
Fomina
T I
TI
Efimova
L A
LA
Zueva
E P
EP
Khotimchenko
M Iu
MIu
Razina
T G
TG
Amosova
E N
EN
Lopatina
K A
KA
Khotimchenko
Iu S
IuS
D000085:Acetates; D000536:Aluminum Hydroxide / Q000627:therapeutic use; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004338:Drug Combinations; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D008276:Magnesium Hydroxide / Q000627:therapeutic use; D008297:Male; D010368:Pectins / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
D000085:Acetates; D000897:Anti-Ulcer Agents; D004338:Drug Combinations; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D010368:Pectins; D008276:Magnesium Hydroxide; C003181:polygalacturonic acid