Anti-diabetic activity of a leaf extract prepared from Salacia reticulata in mice.
The effects of a water extract prepared from the leaves of Salacia reticulata on the absorption of sugars in normal and type 1 diabetic mice were investigated. The simultaneous oral administration of the extract at a dose of 1.0 mg/mouse with maltose or sucrose inhibited the postprandial elevation of the plasma glucose and insulin levels and intestinal alpha-glucosidase activities in mice. In addition, the supply of a 0.01% solution of the extract as drinking water prevented the elevation of the plasma glucose level and intestinal alpha-glucosidase activities in type 1 diabetic mice. This treatment also prevented the elevation of the plasma, pancreatic, and kidney lipid peroxide levels, lowering of the plasma insulin level, and elevation of the kidney aldose reductase activities in diabetic mice. These results suggest that the water extract of the leaves of S. reticulata could be a beneficial food material for the prevention of diabetes and obesity because of its multiple effects.
Department of Chemistry and Biochemistry, Numazu College of Technology, Numazu, Shizuoka, Japan.
Kyoji
K
Yoshino
Yuko
Y
Miyauchi
Takashi
T
Kanetaka
Yasutaka
Y
Takagi
Kunimasa
K
Koga
D000284:Administration, Oral; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000201:enzymology; D004187:Disaccharides / Q000008:administration & dosage / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D007422:Intestines / Q000187:drug effects / Q000201:enzymology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D051379:Mice; D009005:Monosaccharides / Q000008:administration & dosage / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D049918:Salacia / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D000520:alpha-Glucosidases / Q000378:metabolism
D001786:Blood Glucose; D004187:Disaccharides; D007004:Hypoglycemic Agents; D007328:Insulin; D008054:Lipid Peroxides; D009005:Monosaccharides; D010936:Plant Extracts; D014867:Water; D000449:Aldehyde Reductase; D000520:alpha-Glucosidases