A retrospective review of glargine use in pregnancy.
OBJECTIVE
To review the obstetric outcome of 240 diabetic pregnancies maintained on basal glargine insulin.


METHODS
This is a retrospective review of the medical data from 240 pregnant diabetics who received glargine as a basal insulin. Perinatal outcome was abstracted from August 29, 2001, to December 31, 2007.


RESULTS
Mean maternal age was 33 years (SD +/- 5). Seventy-seven percent (184 of 240) of the women were diagnosed with gestational diabetes. The remaining 23% (56 of 240) had a diagnosis of type 2 diabetes. Weekly evaluation of each woman's daily 7x/d fingersticks yielded an individual mean capillary glucose value. These individual mean capillary glucose values were used to calculate a mean value for our sample population. This overall mean capillary glucose value for the 240 parturients was 112 +/- 14.8 mg/dL. The mean neonatal birth weight was 3,142 +/- 606 g. Only 4 neonates had birth weights > 4,000 g (4,365, 4,384, 4,535 and 4,624). None of the neonates were hypoglycemic.


CONCLUSIONS
Prenatal glargine appears to be well tolerated with acceptable perinatal outcome. For well-controlled pregestational diabetics, consideration should be given to continuing glargine during pregnancy.
Henderson
Cassandra E
CE
Department of Obstetrics and Gynecology, Montefiore Medical Center North Division, 600 East 233 Street, 5th Floor, Bronx, NY 10466, USA. chenders@montefiore.org
Machupalli
Surekha
S
Marcano-Vasquez
Heynelda
H
Kerr
Patrick
P
Reilly
Kevin D
KD
D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D002196:Capillaries; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy; D016640:Diabetes, Gestational / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting; D011247:Pregnancy; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics / Q000188:drug therapy; D012189:Retrospective Studies
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine