[Investigation of prophylactic activity of Ingavirin, a new Russian drug, against grippe A virus (H3N2)].
Antiviral efficacy of Ingavirin was studied on albino mice infected intranasally by the grippe A virus (H3N2) vs. Tamiflu, Remantadin and Arbidol. Ingavirin used prophylactically in doses of 5 to 10 mg/kg was shown to be effective in protecting the animals from death and inhibiting the specific hemagglutinin formation and the virus reproduction in the lungs (by the accumulation).
S Ia
SIa
Loginova
S V
SV
Borisevich
V A
VA
Maksimov
V P
VP
Bondarev
V E
VE
Nebol'sin
D000577:Amides; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002208:Caproates; D003998:Dicarboxylic Acids; D004305:Dose-Response Relationship, Drug; D006389:Hemagglutinins, Viral / Q000097:blood; D006801:Humans; D007093:Imidazoles; D053122:Influenza A Virus, H3N2 Subtype; D007251:Influenza, Human / Q000097:blood / Q000517:prevention & control*; D008168:Lung / Q000821:virology; D051379:Mice; D012426:Russia; D014779:Virus Replication / Q000187:drug effects
D000577:Amides; D000998:Antiviral Agents; D002208:Caproates; D003998:Dicarboxylic Acids; D006389:Hemagglutinins, Viral; D007093:Imidazoles; C539419:pentanedioic acid imidazolyl ethanamide