Whole blood reflectance for assessment of hematologic condition and detection of angiographic contrast media.
We present simple whole blood reflectance analyses in the range 500-900 nm, using intact whole blood to simultaneously quantify hematocrit and oxygen saturation from a single spectral reading. We applied these results for the development of an intravascular catheter-based reflectance sensing system to detect and remove contrast media injected during angiography so as to reduce the risk of complications associated with the injected contrast media. We further tested the practicality of the optical detection of angiographic contrast media in a pilot animal study in vivo. We successfully demonstrated the feasibility of real-time in vivo contrast detection and removal during angiography. Our simple method for the detection and removal of angiographic contrast media will facilitate the development of intravascular optical sensing systems.
Center for Cardiovascular Technology, School of Medicine, Stanford University, 300 Pasteur Drive, Room H3554, Stanford, California 94305, USA. changhs@stanford.edu
Hyeonsoo
H
Chang
Young L
YL
Kim
Ali
A
Hassan
Peter J
PJ
Fitzgerald
D000792:Angiography / Q000379:methods*; D000818:Animals; D001774:Blood Chemical Analysis / Q000379:methods*; D001798:Blood Proteins / Q000032:analysis*; D003287:Contrast Media / Q000032:analysis*; D006402:Hematologic Diseases / Q000097:blood* / Q000175:diagnosis; D013058:Mass Spectrometry / Q000379:methods*; D010783:Photometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012756:Sheep; D013552:Swine
D001798:Blood Proteins; D003287:Contrast Media