Evaluation of relaxin's antifibrotic action by SELDI-TOF mass spectrometry-based profiling of relaxin knockout mice, a model of progressive fibrosis.
Surface-enhanced laser desorption ionization-time-of-flight mass spectrometry was employed to identify potential biomarkers for early-onset fibrosis. These biomarkers were then used to evaluate the efficacy of relaxin to reverse or ameliorate the development of the condition.
Howard Florey Institute, University of Melbourne, Victoria 3010, Australia.
Eleni
E
Giannakis
Mary
M
Macris
Linda
L
Chan
Geoffrey W
GW
Tregear
Chrishan S
CS
Samuel
John D
JD
Wade
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D005355:Fibrosis / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation / Q000187:drug effects*; D051379:Mice; D018345:Mice, Knockout; D012065:Relaxin / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
D015415:Biomarkers; D012065:Relaxin