Palladium-catalyzed cyanation of carbon-carbon triple bonds under aerobic conditions.
Essential oxygen: The title transformation involves two different modes of cyanation, syn and anti cyanopalladation, as the key steps in this catalytic reaction. These processes enable successful dicyanative cyclization of diyne and enyne derivatives (see scheme).
Arai
Shigeru
S
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, Japan. arai@p.chiba-u.ac.jp
Sato
Takashi
T
Koike
Yuka
Y
Hayashi
Michino
M
Nishida
Atsushi
A
D000388:Air; D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D010165:Palladium / Q000737:chemistry*
D000480:Alkynes; D003486:Cyanides; D010165:Palladium