Do cancer cells care if their host is hungry?
A recent report by Kalaany and Sabatini concerning mechanisms underlying the inhibitory effect of dietary restriction on the growth of certain tumors adds to the evidence that insulin and IGF-I are hormones with relevance to oncology.
Pollak
Michael
M
Department of Medicine, McGill University, Montreal, Quebec, Canada. michael.pollak@mcgill.ca
D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000818:Animals; D004032:Diet; D004734:Energy Metabolism; D007328:Insulin / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D051379:Mice; D009369:Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D014183:Transplantation, Heterologous
D007328:Insulin; D007334:Insulin-Like Growth Factor I; D019869:Phosphatidylinositol 3-Kinases; D055372:AMP-Activated Protein Kinases; D051059:PTEN Phosphohydrolase; C487757:Pten protein, mouse