A powerful chiral counteranion motif for asymmetric catalysis.
Room to swing a cat: A chiral disulfonimide has been designed as a powerful new motif for asymmetric catalysis. As a first illustration, a highly efficient and enantioselective Mukaiyama aldol reaction has been developed (see scheme). The actual catalyst is proposed to be an N-silyl imide which is generated in situ.
García-García
Pilar
P
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
Lay
Frank
F
García-García
Patricia
P
Rabalakos
Constantinos
C
List
Benjamin
B
D000838:Anions / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007094:Imides / Q000737:chemistry; D007536:Isomerism; D010756:Phosphoric Acids / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry*
D000838:Anions; D007094:Imides; D010756:Phosphoric Acids; D013450:Sulfones; C030242:phosphoric acid