Electrical-sensitive nanoparticle composed of chitosan and tetraethyl orthosilicate for controlled drug release.
In the present study, the nanoparticles with size of 50-130 nm composed of chitosan (CS) and tetraethyl orthosilicate (TEOS), which showed electrically-controlled release profile, were prepared. Myoglobin was encapsulated into the nanoparticles with an encapsulation efficiency as high as 91.5% and a maximum loading capacity of 70.2% that can be achieved. Here, TEOS was hydrolyzed and condensed to form interpenetration network with CS. Increase of TEOS content results in a shift of the release profile from swelling-controlled towards diffusion-controlled mechanism. The "slow-to-burst" and "near-zero" release of the myoglobin can be effectively controlled by applying DC electric field between "on" and "off".
Liu
Kun-Ho
KH
Department of Materials Sciences and Engineering, National Chiao Tung University, Hsinchu, Taiwan, 300, ROC.
Liu
Ting-Yu
TY
Liu
Dean-Mo
DM
Chen
San-Yuan
SY
D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D017640:Silicates / Q000737:chemistry*
D004364:Pharmaceutical Preparations; D017640:Silicates; D048271:Chitosan