Alzheimer's disease and corticobasal degeneration presenting as corticobasal syndrome.
The aim of this article is to compare patients with Alzheimer's disease (AD) pathology and corticobasal degeneration pathology (CBD) presenting as corticobasal syndrome (CBS). Clinicopathologic series was used. Five patients with AD and 11 patients with CBD were clinically diagnosed with CBS. Patients with AD pathology had an earlier age of onset than patients with CBD pathology (58 vs. 68 years, P = 0.004), but the two groups had similar disease duration and core features of CBS. Tremors were only present in CBD cases (73%, P = 0.026), but myoclonus was more common in AD than CBD (80 vs. 18%, P = 0.036). Neuropsychological testing showed similar degrees of memory impairment and attentional deficits. (99m)Tc-HMPAO SPECT imaging demonstrated parietal hypoperfusion in AD patients and frontotemporal hypoperfusion in CBD patients. AD patients with clinical CBS have similar characteristics to CBD patients. Functional brain imaging may have greater utility than the clinical and neuropsychological features in differentiating AD presenting as CBS from CBD.
Hu
William T
WT
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Rippon
Gregory W
GW
Boeve
Bradley F
BF
Knopman
David S
DS
Petersen
Ronald C
RC
Parisi
Joseph E
JE
Josephs
Keith A
KA
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D001344:Autopsy / Q000379:methods; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D019690:Technetium Tc 99m Exametazime