Clinical spectrum of vulva metastatic Crohn's disease.
Crohn's disease is a chronic granulomatous disorder that may involve any segment of the gastrointestinal tract. Extraintestinal manifestations of Crohn's disease such as erythema nodosum and pyoderma gangrenosum are well recognized and appreciated. However, metastatic Crohn's disease (MCD), defined as the same granulomatous inflammation seen in Crohn's disease but at a skin site distant to the gastrointestinal tract, is less well recognized. We report three cases of MCD involving the perianal and vulvar skin that initially presented with vulvar pain.
Department of Medicine, Northwestern University Feinberg School of Medicine, 251 East Huron St., Galter Pavilion, Suite 3-150, Chicago, IL 60611, USA. susanleu@gmail.com
Susan
S
Leu
Patricia K
PK
Sun
James
J
Collyer
Aimee
A
Smidt
Catherine S
CS
Stika
Bethanee
B
Schlosser
Ginat W
GW
Mirowski
Arvydas
A
Vanagunas
Alan L
AL
Buchman
D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D001379:Azathioprine / Q000008:administration & dosage; D003106:Colon / Q000473:pathology; D003113:Colonoscopy; D003424:Crohn Disease / Q000175:diagnosis / Q000473:pathology*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D004487:Edema / Q000209:etiology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D000069285:Infliximab; D008875:Middle Aged; D010173:Palpation; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014845:Vulvar Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*
D000911:Antibodies, Monoclonal; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D001379:Azathioprine; D011241:Prednisone