A microreactor with thousands of subcompartments: enzyme-loaded liposomes within polymer capsules.
Fully loaded: Noncovalent anchoring of liposomes into polymer multilayered films with cholesterol-modified polymers allows the preparation of capsosomes-liposome-compartmentalized polymer capsules (see picture). A quantitative enzymatic reaction confirmed the presence of active cargo within the capsosomes and was used to determine the number of subcompartments within this novel biomedical carrier system.
Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
Brigitte
B
Städler
Rona
R
Chandrawati
Andrew D
AD
Price
Siow-Feng
SF
Chong
Kerry
K
Breheney
Almar
A
Postma
Luke A
LA
Connal
Alexander N
AN
Zelikin
Frank
F
Caruso
D002214:Capsules; D008081:Liposomes / Q000737:chemistry*; D017830:Octoxynol / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D001618:beta-Lactamases / Q000737:chemistry* / Q000378:metabolism
D002214:Capsules; D008081:Liposomes; D011108:Polymers; D017830:Octoxynol; D001618:beta-Lactamases