Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome.
Bisphenol A (BPA) is one of the most prevalent and best studied endocrine disruptors. After years of exposure to consumer products containing BPA, most individuals tested have circulating BPA at the low nanomolar levels. In addition to its well documented actions on the reproductive system, BPA exerts a wide variety of metabolic effects. This review summarizes recent findings on the ability of BPA, at environmentally relevant doses, to inhibit adiponectin and stimulate the release of inflammatory adipokines such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) from human adipose tissue. Expression of several classical and non-classical estrogen receptors in human adipose tissue raises the possibility of their involvement as mediators of BPA actions. The implications of these observations to the obesity-related metabolic syndrome and its sequelae are discussed.
Ben-Jonathan
Nira
N
Department of Cancer and Cell Biology, University of Cincinnati, OH 45267, USA. Nira.Ben-Jonathan@uc.edu
Hugo
Eric R
ER
Brandebourg
Terry D
TD
D054392:Adipokines / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000395:Air Pollutants, Occupational / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004968:Estrogens, Non-Steroidal / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D024821:Metabolic Syndrome / Q000378:metabolism*; D015394:Molecular Structure; D009765:Obesity / Q000378:metabolism; D010636:Phenols / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D000098826:Bisphenol A Compounds
D054392:Adipokines; D052242:Adiponectin; D000395:Air Pollutants, Occupational; D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004968:Estrogens, Non-Steroidal; D015850:Interleukin-6; D010636:Phenols; D011960:Receptors, Estrogen; D014409:Tumor Necrosis Factor-alpha; C006780:bisphenol A; D000098826:Bisphenol A Compounds