Near-infrared spectroscopy for evaluation of cerebral autoregulation during orthotopic liver transplantation.
BACKGROUND
The present study evaluated whether frontal lobe cerebral oxygenation (S(c)O(2)), as assessed by near-infrared spectroscopy (NIRS), can detect cerebral autoregulation in patients undergoing orthotopic liver transplantation.


METHODS
We studied changes in frontal lobe S(c)O(2) assessed in 33 patients, 19 females, who underwent orthotopic liver transplantation (OLT). We evaluated whether S(c)O(2) would remain stable over a wide range of MAP and whether an eventual drop in S(c)O(2) could be related to a low MAP.


RESULTS
Among the 31 of 33 patients for whom a NIRS signal could be detected, S(c)O(2) varied in parallel with mean arterial pressure (MAP) for 3 patients and, therefore, an autoregulation curve could not be established and yet, there was detected no change in S(c)O(2) to a lowest MAP ranging from 42 to 66 mmHg for 20 patients, while for 8 patients a decrease in S(c)O(2) was detected at a MAP of 69 (50-90) mmHg; (median and range). As detected by NIRS, the present study confirms that some patients undergoing liver transplantation do not demonstrate cerebral autoregulation but for the majority of the patients, S(c)O(2) was stable over a wide range of MAP suggesting that S(c)O(2) detects cerebral autoregulation.


CONCLUSIONS
We find that NIRS is a ready available non-invasive technology for evaluation of cerebral autoregulation in patients undergoing orthotopic liver transplantation.
Nissen
Peter
P
Department of Anesthesia, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. p.nissen@rh.regionh.dk
Pacino
Heidi
H
Frederiksen
Hans J
HJ
Novovic
Srdan
S
Secher
Niels H
NH
D000328:Adult; D001794:Blood Pressure; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D002245:Carbon Dioxide / Q000032:analysis; D002302:Cardiac Output; D005260:Female; D005625:Frontal Lobe / Q000502:physiology / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D008107:Liver Diseases / Q000145:classification / Q000601:surgery; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D012086:Reoperation / Q000706:statistics & numerical data; D013055:Spectrophotometry, Infrared; D055815:Young Adult
D002245:Carbon Dioxide