An efficient one-pot copper-catalyzed approach to isoquinolin-1(2H)-one derivatives.
A simple and efficient copper-catalyzed method for synthesis of 3,4-disubstituted isoquinolin-1(2H)-one derivatives via cascade reactions of substituted 2-halobenzamides with beta-keto esters under mild conditions has been developed, and the method has economical and practical advantages.
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Feng
F
Wang
Hongxia
H
Liu
Hua
H
Fu
Yuyang
Y
Jiang
Yufen
Y
Zhao
D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D001549:Benzamides; D006846:Hydrocarbons, Halogenated; D007546:Isoquinolines; D003300:Copper