Organometallic compounds in oncology: implications of novel organotins as antitumor agents.
Since the introduction of cisplatin in cancer therapy, metal complexes and organometallic compounds have been gaining growing importance in oncology. The impressive clinical effectiveness of cisplatin is limited by significant side effects and the emergence of drug resistance. Thus, novel classic and unconventional Pt(II) and Pt(IV) complexes have been introduced in therapy or are presently in advanced clinical trials. Moreover, innovative non-platinum metal-based antitumor agents, whose activity does not rely on direct DNA damage and may involve proteins and enzymes, have been developed. Gold and tin derivatives are enjoying an increasing interest and appear very promising as potential drug candidates.
Alama
Angela
A
Tumor Genetic, Lung Cancer Unit, National Institute for Cancer Research, Largo R. Benzi 10, 16132 Genoa, Italy. angela.alama@istge.it
Tasso
Bruno
B
Novelli
Federica
F
Sparatore
Fabio
F
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008495:Medical Oncology / Q000379:methods*; D009942:Organometallic Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D009947:Organotin Compounds / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D009947:Organotin Compounds; D002945:Cisplatin