Association between neuropsychiatric morbidity and streptococcal infections in children.
We conducted a case control study to study the association between neuropsychiatric morbidity and group A streptococcal infections in children. Twenty two cases of neuropsychiatric morbidity were compared with 64 controls. Fourteen (63.6%) of the 22 cases were positive for ASO and/or ADNB while 21 of the 64 controls (32.8%) were positive for either or both antibodies (OR = 3.428; CI: 1.15-10.18; P=0.026). We conclude that there is a statistically significant association between neuropsychiatric morbidity and streptococcal infection in children.
Department of Child Health, Christian Medical College, Vellore, Tamil Nadu, India.
S
S
Viswanathan
P D
PD
Moses
S
S
Varkki
P S
PS
Russell
K N
KN
Brahmadathan
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D001426:Bacterial Proteins / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003851:Deoxyribonucleases / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000276:immunology / Q000382:microbiology*; D013290:Streptococcal Infections / Q000276:immunology / Q000523:psychology*; D013301:Streptolysins / Q000276:immunology
D001323:Autoantibodies; D001426:Bacterial Proteins; D013301:Streptolysins; C025964:streptolysin O; D003851:Deoxyribonucleases