Asymmetric Co(II)-catalyzed cyclopropanation with succinimidyl diazoacetate: general synthesis of chiral cyclopropyl carboxamides.
[Co(P1)] is an effective catalyst for asymmetric cyclopropanation with succinimidyl diazoacetate. The Co(II)-catalyzed reaction is suitable for various olefins, providing the desired cyclopropane succinimidyl esters in high yields and excellent diastereo- and enantioselectivity. The resulting enantioenriched cyclopropane succinimidyl esters can serve as convenient synthons for the general synthesis of optically active cyclopropyl carboxamides.
Department of Chemistry, University of South Florida, Tampa, Florida 33620-5250, USA.
Joshua V
JV
Ruppel
Ted J
TJ
Gauthier
Nicole L
NL
Snyder
Jason A
JA
Perman
X Peter
XP
Zhang