Traceless solid phase synthesis of natural product inspired cis-1,2-dehydrodecalins.
A tetrazole-based traceless linker for Diels-Alder reactions on solid support which can be cleaved by Pd(0)-, Cu(I)- and Ag(I)-assisted nucleophilic displacements has been developed and applied to the solid-phase/traceless release synthesis of natural product inspired cis-decalins.
Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.
Masahito
M
Yoshida
Christian
C
Hedberg
Markus
M
Kaiser
Herbert
H
Waldmann
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013237:Stereoisomerism; D013777:Tetrazoles / Q000138:chemical synthesis / Q000737:chemistry*
D009281:Naphthalenes; D013777:Tetrazoles; C045574:1H-tetrazole; D012834:Silver; D010165:Palladium; D003300:Copper; C007229:decalin