Adjuncts for ovarian stimulation: when do we adopt "orphan indications" for approved drugs?
Several drugs, shown to be safe for other uses, have proven to be highly effective adjuncts for ovarian stimulation. The authors evaluate these "orphan" indications and make recommendations so that more patients will benefit from their use.
Meldrum
David R
DR
Reproductive Partners Medical Group, 510 North Prospect Avenue, Redondo Beach, CA90277, USA. davidmeldrum@earthlink.net
Chang
R Jeffrey
RJ
de Ziegler
Dominique
D
Schoolcraft
William B
WB
Scott
Richard T
RT
Pellicer
Antonio
A
D000728:Androgens / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D003276:Contraceptives, Oral / Q000627:therapeutic use; D018491:Dopamine Agonists / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use; D009965:Orphan Drug Production / Q000706:statistics & numerical data*; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*
D000728:Androgens; D003276:Contraceptives, Oral; D018491:Dopamine Agonists; D004967:Estrogens; D019382:Human Growth Hormone; D008687:Metformin; D016729:Leuprolide; D001241:Aspirin