Application of copper(II)-dipyridylphosphine catalyst in the asymmetric hydrosilylation of simple ketones in air.
Ask a copper: A copper(II) salt/chiral dipyridylphosphine/PhSiH(3) system (see scheme) acts as a very effective and practical catalyst for the asymmetric reduction of heteroaromatic and other types of ketones in air with good-to-excellent enantioselectivities (up to 94%), giving many chiral alcohols that are intermediates for physiologically active compounds. Remarkable temperature effects were observed for some heteroaromatic ketones.
Zhang
Xi-Chang
XC
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310036, PR China.
Wu
Yan
Y
Yu
Feng
F
Wu
Fei-Fei
FF
Wu
Jing
J
Chan
Albert S C
AS
D000388:Air; D002384:Catalysis; D003300:Copper; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012821:Silanes; D013237:Stereoisomerism
D007659:Ketones; D009942:Organometallic Compounds; D012821:Silanes; D003300:Copper