[The influence of melatonin and epithalon on blood leukocyte count and leukocyte alkaline phosphatase in rats under different lighting conditions during ontogenesis].
The effect of pineal body hormone melatonin and synthetic tetrapeptide epithalon (Ala-Glu-Asp-Gly) under different light conditions on leucocytes differential count in rats were investigated. It has been established that melatonin and epithalon decrease the level of blood leucocytes and relative content of band neutrophils in 12 months rats which was higher in the constant light more than in other photoperiod. The melatonin prevents age-specific decreasing blood lymphocytes level in standard photoperiod (12 h light/12 h darkness). Contrary to melatonin, epithalon significantly reduces the number of lymphocytes and increases the number of neutrophils in some age period. The leucocytes alkaline phosphatase activity was increased during aging. Constant light in compare with other light conditions promotes early increasing of alkaline phosphatase activity (at 12 months), associated with accelerated development of pathological process in organism. The melatonin and epithalon adjacency effect on increasing of alkaline phosphatase activity under the standard as well as natural light condition demonstrate homeostatic character of geroprotectors action furthermore depend on leucocytes functional status.
Uzenbaeva
L B
LB
Vinogradova
I A
IA
Golubeva
A G
AG
Niuppieva
M G
MG
Iliukha
V A
VA
D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D005260:Female; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology* / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D017440:Photoperiod; D051381:Rats
D009842:Oligopeptides; D000469:Alkaline Phosphatase; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine