Ultrasound-promoted a green protocol for the synthesis of 2,4-diarylthiazoles under ambient temperature in [bmim]BF(4).
A mild, efficient, facile and eco-friendly procedure for the synthesis of 2,4-diarylthiazoles from arylthioamides and alpha-bromoacetophenones in 1-n-butyl-3-methylimidazolium tetrafluoroborate as a "green" media under ultrasound irradiation at room temperature is described. It is interesting to mention that only one product was obtained when two different alpha-bromoacetophenones were reacted with 1,3-phenyl dithioamide as the substrate. Work-up is very simple and there is no need to purify the product. A recycling study confirmed that the ionic liquid can be reused multiple times without a significant loss in its activity.
Catalysis Division, Department of Chemistry, University of Isfahan, Isfahan 81746-73441, Iran.
Jalil
J
Noei
Ahmad Reza
AR
Khosropour
D055772:Green Chemistry Technology / Q000379:methods*; D007093:Imidazoles / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014465:Ultrasonics
C419324:1-butyl-3-methylimidazolium tetrafluoroborate; D007093:Imidazoles; D012997:Solvents; D013844:Thiazoles