Proinflammatory cytokines in temporomandibular joint synovial fluid before and after arthrocentesis.
OBJECTIVE
The aim of this study was to evaluate the levels of interleukin (IL)-1beta, IL-6, IL-8, IL-11, and tumor necrosis factor (TNF)-alpha in temporomandibular joint (TMJ) synovial fluid of the patients with internal derangement before and 2 weeks after arthrocentesis.


METHODS
Forty TMJs of 35 patients (29 females and 6 males, mean age 22.9 years) were included to the study. TMJs were divided into 2 groups: disc displacement with reduction (Group 1, n = 24) and disc displacement without reduction (Group 2, n = 16). Synovial fluid samples were obtained before and 2 weeks after arthrocentesis. IL-1beta, IL-6, IL-8, IL-11, and TNF-alpha concentrations were measured by using specific kits.


RESULTS
Two weeks after the arthrocentesis procedures, all cytokines were found to be significantly decreased (P < .05) both in Group 1 and Group 2. The difference between 2 groups was insignificant (P > .05).


CONCLUSIONS
Arthrocentesis is an effective technique for eliminating the studied cytokines from the TMJ synovial fluid.
Selcuk University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Konya, Turkey.
Huseyin
H
Gulen
Hanife
H
Ataoglu
Seyfullah
S
Haliloglu
Kubilay
K
Isik
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007378:Interleukins / Q000032:analysis / Q000378:metabolism*; D004204:Joint Dislocations / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008297:Male; D019152:Paracentesis; D013582:Synovial Fluid / Q000737:chemistry*; D013585:Synovitis / Q000276:immunology / Q000378:metabolism / Q000601:surgery; D013705:Temporomandibular Joint Disorders / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000378:metabolism*; D055815:Young Adult
D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha