Autoimmunity: CTLA-4: a key protein in autoimmunity.
Studies performed during the past 2 years have provided a deeper understanding into the role of CTLA-4, which is expressed on regulatory T cells, in preventing autoimmunity, and also provide mechanistic insight into protein-based therapeutics such as abatacept for rheumatic diseases.
Bayry
Jagadeesh
J
Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Paris, France. jagadeesh.bayry@crc.jussieu.fr
D015703:Antigens, CD / Q000502:physiology*; D015551:Autoimmunity / Q000502:physiology*; D018122:B7-1 Antigen / Q000378:metabolism; D051940:B7-2 Antigen / Q000378:metabolism; D060908:CTLA-4 Antigen; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497964:CD86 protein, human; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human