Purine uptake in Plasmodium: transport versus metabolism.
In a recent paper, Quashie et al. have proposed that purine uptake into the intraerythrocytic malaria parasite involves four different plasma membrane transporters - two high affinity and two low affinity. They equate one of the two high-affinity transporters with PfNT1, a transporter reported previously to be a low-affinity system. Here, we offer an alternative interpretation of their data, suggesting that the conclusions drawn by Quashie et al. take insufficient account of metabolism.
Biochemistry and Molecular Biology, School of Biology, The Australian National University, Canberra ACT 0200, Australia. kiaran.kirk@anu.edu.au
Kiaran
K
Kirk
Susan M
SM
Howitt
Stefan
S
Bröer
Kevin J
KJ
Saliba
Megan J
MJ
Downie
D000818:Animals; D001692:Biological Transport; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009865:Oocytes / Q000378:metabolism; D010963:Plasmodium falciparum / Q000378:metabolism* / Q000502:physiology*; D015800:Protozoan Proteins / Q000378:metabolism*; D011687:Purines / Q000378:metabolism*; D014982:Xenopus laevis / Q000469:parasitology
D026901:Membrane Transport Proteins; C407347:NT1 protein, Plasmodium falciparum; D015800:Protozoan Proteins; D011687:Purines; C030985:purine