[Individual activity of renal enzymes in the susceptibility of hydronephrotic rabbits to aminoglycoside (gentamicin) nephrotoxicity].
A correlation between the individual features of the activity of renal enzymes and the expression of aminoglycoside (gentamicin) induced nephrotoxicity is established in hydronephrotic rabbits. The level of gentamicin-induced damage of the kidney is more significant in rabbits with initially (prior to gentamicin administration) increased activity of lactate dehydrogenase, decreased activity of succinate dehydrogenase and acid phosphatase, and low content of ribonucleoproteins.
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D000135:Acid Phosphatase / Q000378:metabolism; D000617:Aminoglycosides / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D004198:Disease Susceptibility; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D006869:Hydronephrosis / Q000150:complications / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000503:physiopathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D011817:Rabbits; D012261:Ribonucleoproteins / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D012261:Ribonucleoproteins; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase