[Transcriptional regulation of proteasomal genes in eukaryotes].
The ubuquitin-proteasome system is involved in degradation of many intracellular proteins and is necessary for proper functioning of the cell under normal conditions and its survival under stress conditions. In this review the general principles of structure and functioning of the ubiquitin-proteasome proteolytic system is considered. The main attention was paid for regulation of proteasomal genes expression, and specifically for discovery and analysis of Rpn4p transcription factor, an activator for proteasomal genes in Saccharomyces cerevisiae. The data about regulation of proteasomal genes expression in higher eukaryotes is also discussed.
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Karpov
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Preobrazhenskaia
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Karpov
D000818:Animals; D005057:Eukaryotic Cells / Q000201:enzymology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000096:biosynthesis* / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000096:biosynthesis / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination / Q000502:physiology*
D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex