A supramolecular approach for preparation of size-controlled nanoparticles.
A supramolecular approach has been developed for the preparation of supramolecular nanoparticles (SNPs) with variable sizes (30-450 nm) from three different molecular building blocks using a cyclodextrin/adamantane recognition system. Positron emission tomography (PET) was employed to study the biodistribution and lymph node drainage of the SNPs in mice. The sizes of the SNPs affect their in vivo characteristics (see picture).
Wang
Hao
H
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA.
Wang
Shutao
S
Su
Helen
H
Chen
Kuan-Ju
KJ
Armijo
Amanda Lee
AL
Lin
Wei-Yu
WY
Wang
Yanju
Y
Sun
Jing
J
Kamei
Ken-ichiro
K
Czernin
Johannes
J
Radu
Caius G
CG
Tseng
Hsian-Rong
HR
D000218:Adamantane / Q000737:chemistry; D000818:Animals; D003300:Copper / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry; D007553:Isotope Labeling; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D049268:Positron-Emission Tomography
D003505:Cyclodextrins; D003300:Copper; D000218:Adamantane