Synthesis and antimycobacterial activity of 5-formylaminopyrimidines; analogs of antibacterial purines.
Pyrimidine analogs of antimycobacterial purines have been synthesized and their biological activities evaluated. Several 5-formamidopyrimidines exhibited profound activity against Mycobacterium tuberculosis in vitro (IC(90)< or =1.5 microg/mL), and they were essentially inactive against other bacteria.
Braendvang
Morten
M
Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N-0315 Oslo, Norway.
Charnock
Colin
C
Gundersen
Lise-Lotte
LL
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011687:Purines / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D011687:Purines; D011743:Pyrimidines