L-carnitine in beta thalassemia.
This study was conducted to determine L-carnitine levels in regularly transfused and chelated beta thalassemia patients (n=40; mean age, 17.5+/-5.0 years). Ten age matched controls were also studied. The mean L-carnitine level in thalassemic patients was 23.71+/- 7.3 microM as compared to control 29.26+/-2.37 microM (P<0.0001). Mean carnitine was significantly lower (P=0.037) in those with ferritin greater than 2000 ng/dL (22.80+/-6.97 microM) in comparison to those with ferritin less than 2000 ng/dL (30.1+/-7.77 microM). Although carnitine levels in non vegetarians was higher (26.91+/-8.4 microM) than in vegetarians (22.34+/-6.55 microM), this difference was not statistically significant (P=0.072). We conclude that L-carnitine levels were found to be lower in thalassemics as compared to age matched controls.
Merchant
Rashid
R
Department of Pediatrics, Dr Bhalabhai Nanavati Hospital, Mumbai, India. deandoc2000@hotmail.com
Jain
Abhay
A
Udani
Amish
A
Puri
Vipla
V
Kotian
Mallika
M
D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D002331:Carnitine / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D014676:Diet, Vegetarian; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007194:India; D008297:Male; D017086:beta-Thalassemia / Q000097:blood* / Q000628:therapy
D005293:Ferritins; D002331:Carnitine