The role of IP3R clustering in Ca2+ signalinG.
Ca(2+) is the most important second messenger controlling a variety of intracellular processes by oscillations of the cytosolic Ca(2+) concentration. These oscillations occur by Ca(2+) release from the endoplasmic reticulum (ER) into the cytosol through channels and the re-uptake of Ca(2+) into the ER by pumps. A common channel type present in many cell types is the inositol trisphosphate receptor (IP(3)R), which is activated by IP(3) and Ca(2+) itself leading to Ca(2+) induced Ca(2+) release (CICR). We have shown in an experimental study, that Ca(2+) oscillations are sequences of random spikes that occur by wave nucleation. We use here our recently developed model for Ca(2+) dynamics in 3 dimension to illuminate the role of IP(3)R clustering within spatial extended systems.
Skupin
Alexander
A
Max-Delbrück-Center for Molecular Medince, Departement of Mathematical Cell Physiology, Robert-Rössle-Str. 10, 13125 Berlin, Germany. alexander.skupin@hmi.de
Falcke
Martin
M
D000818:Animals; D002118:Calcium / Q000502:physiology*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D003600:Cytosol / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000502:physiology; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology; D011336:Probability; D015398:Signal Transduction
D053496:Inositol 1,4,5-Trisphosphate Receptors; D007473:Ion Channels; D000252:Calcium-Transporting ATPases; D002118:Calcium