Application of copper(II)-dipyridylphosphine catalyst in the asymmetric hydrosilylation of simple ketones in air.
Ask a copper: A copper(II) salt/chiral dipyridylphosphine/PhSiH(3) system (see scheme) acts as a very effective and practical catalyst for the asymmetric reduction of heteroaromatic and other types of ketones in air with good-to-excellent enantioselectivities (up to 94%), giving many chiral alcohols that are intermediates for physiologically active compounds. Remarkable temperature effects were observed for some heteroaromatic ketones.
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310036, PR China.
Xi-Chang
XC
Zhang
Yan
Y
Wu
Feng
F
Yu
Fei-Fei
FF
Wu
Jing
J
Wu
Albert S C
AS
Chan
D000388:Air; D002384:Catalysis; D003300:Copper; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012821:Silanes; D013237:Stereoisomerism
D007659:Ketones; D009942:Organometallic Compounds; D012821:Silanes; D003300:Copper