Severe neonatal renal failure after maternal use of angiotensin II type I receptor antagonists.
Sartans are selective type 1 angiotensin II receptor antagonists that are used for treatment of arterial hypertension. We report a case of severe renal failure required dialysis after the use of olmesartan in the last month of pregnancy. Exposure to sartans during the last period of gestation seems to be associated with high risk of congenital malformations. It is important to stress that the use of these drugs during pregnancy must be avoided, especially in the third trimester.
Sinelli
M T
MT
Division of Neonatology and Neonatal Intensive Care Unit, Spedali Civili, Pzzale Spedali Civili, 1-25100 Brescia.
Cattarelli
D
D
Cortinovis
S
S
Maroccolo
D
D
Chirico
G
G
D000328:Adult; D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects*; D001034:Apgar Score; D001724:Birth Weight; D017809:Fatal Outcome; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007093:Imidazoles / Q000009:adverse effects*; D007231:Infant, Newborn; D007687:Kidney Tubules, Proximal / Q000473:pathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000473:pathology; D013777:Tetrazoles / Q000009:adverse effects*
D047228:Angiotensin II Type 1 Receptor Blockers; D007093:Imidazoles; D013777:Tetrazoles; C437965:olmesartan