Abnormal fetal cerebral laminar organization in cobblestone complex as seen on post-mortem MRI and DTI.
We report a unique case of cobblestone complex using post-mortem MR and diffusion tensor imaging to assess the laminar organization of the fetal cerebrum. The imaging findings were correlated with autopsy findings. Abnormal cortical development in cobblestone complex resulted in disruption of normal laminar organization of the fetal brain, which was seen as interruption and nodularity of the high-signal T1 cortical band with increased anisotropy and medium diffusivity extending beyond the cortical band into the cerebral mantle on post-mortem MR and diffusion tensor imaging.
Widjaja
Elysa
E
Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave., Toronto, Canada. Elysa.Widjaja@sickkids.ca
Geibprasert
Sasikhan
S
Blaser
Susan
S
Rayner
Tammy
T
Shannon
Patrick
P
D001344:Autopsy; D001921:Brain / Q000196:embryology* / Q000473:pathology*; D054222:Cobblestone Lissencephaly / Q000523:psychology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male