Association of insulin resistance with anti-Mullerian hormone levels in women without polycystic ovary syndrome (PCOS).
OBJECTIVE
To explore the relationship of insulin resistance (IR) and adipokines (leptin, adiponectin, RBP4) to anti-Mullerian hormone (AMH) levels in women without polycystic ovary syndrome (PCOS).


METHODS
We recruited 120 healthy, reproductive age women without PCOS. An overnight fasting blood draw, anthropometric measurements, analyses of serum levels of AMH, adipokines (leptin, adiponectin and RBP4) and total testosterone, a homeostasis model assessment for insulin resistance (HOMA-IR) and a transvaginal ultrasound scan were performed between the third and fifth day of their spontaneous menstrual cycles.


RESULTS
Higher HOMA-IR levels were associated with lower levels of AMH. After adjustment for age, serum AMH levels negatively correlated with insulin, fasting glucose, HOMA-IR and RBP4. However, a positive correlation was identified between serum AMH and adiponectin. A final multiple stepwise linear regression demonstrated that HOMA-IR was independently associated with AMH.


CONCLUSIONS
An independent relationship exists between HOMA-IR and AMH in women without PCOS, possibly due to the effect of abnormal insulin action on AMH secretion by granulosa cells.
Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
Hyun T
HT
Park
Geum J
GJ
Cho
Ki H
KH
Ahn
Jung H
JH
Shin
Young T
YT
Kim
Jun Y
JY
Hur
Sun H
SH
Kim
Kyu W
KW
Lee
Tak
T
Kim
D052242:Adiponectin / Q000097:blood; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism*; D012044:Regression Analysis; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis
C499918:ADIPOQ protein, human; D052242:Adiponectin; D007328:Insulin; D020738:Leptin; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D054304:Anti-Mullerian Hormone