Rhinofacial conidiobolomycosis caused by Conidiobolus coronatus in a Chinese rice farmer.
We provide the first report of rhinofacial conidiobolomycosis caused by Conidiobolus coronatus in China. The patient was a 36-year-old male rice farmer from Jiang Xi province who presented with diffuse swelling with classical centrofacial distribution and involvement of the right paranasal sinuses. Histopathology showed granulomas with hyphae surrounded by an eosinophilic sheath (Splendore-Hoeppli phenomenon). Culture of biopsy specimens on Sabouraud's dextrose agar led to the growth of fungi with microscopically visible conidiophores and terminal spherical conidia (primary conidium), with multiple secondary conidia and villose conidia. The patient was successfully treated with combination therapy, primarily itraconazole and terbinafine. We conclude with a brief literature review of the epidemiology of conidiobolomycosis.
Yang
Xiumin
X
Li
Yadi
Y
Zhou
Xiaoqian
X
Wang
Yuxin
Y
Geng
Suying
S
Liu
Honggang
H
Yang
Qingwen
Q
Lu
Xinxin
X
Hiruma
Masataro
M
Sugita
Takashi
T
Ikeda
Shigaku
S
Ogawa
Hideoki
H
D000328:Adult; D000383:Agriculture; D000935:Antifungal Agents / Q000627:therapeutic use; D044466:Asian People; D002681:China; D020092:Conidiobolus / Q000166:cytology / Q000254:growth & development / Q000302:isolation & purification*; D003470:Culture Media / Q000737:chemistry; D004359:Drug Therapy, Combination; D005145:Face / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D025301:Hyphae / Q000166:cytology; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D009172:Mycology / Q000379:methods; D009281:Naphthalenes / Q000627:therapeutic use; D012275:Oryza; D010256:Paranasal Sinuses / Q000382:microbiology* / Q000473:pathology*; D000077291:Terbinafine; D020096:Zygomycosis / Q000175:diagnosis* / Q000382:microbiology
D000935:Antifungal Agents; D003470:Culture Media; D009281:Naphthalenes; D017964:Itraconazole; D000077291:Terbinafine