Intraneural ganglia: a clinical problem deserving a mechanistic explanation and model.
Intraneural ganglion cysts have been considered a curiosity for 2 centuries. Based on a unifying articular (synovial) theory, recent evidence has provided a logical explanation for their formation and propagation. The fundamental principle is that of a joint origin and a capsular defect through which synovial fluid escapes following the articular branch, typically into the parent nerve. A stereotypical, reproducible appearance has been characterized that suggests a shared pathogenesis. In the present report the authors will provide a mechanistic explanation that can then be mathematically tested using a preliminary model created by finite element analysis.
Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, Michigan, USA.
Shreehari
S
Elangovan
Gregory M
GM
Odegard
Duane A
DA
Morrow
Huan
H
Wang
Marie-Noëlle
MN
Hébert-Blouin
Robert J
RJ
Spinner
D003198:Computer Simulation; D020342:Finite Element Analysis; D045888:Ganglion Cysts / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007596:Joints / Q000294:innervation / Q000473:pathology / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D011312:Pressure / Q000009:adverse effects; D013582:Synovial Fluid / Q000502:physiology; D013583:Synovial Membrane / Q000294:innervation / Q000473:pathology / Q000503:physiopathology*