New endoscopic and cytologic tools for cancer surveillance in the digestive tract.
Cancer surveillance is an increasing part of everyday practice in gastrointestinal Endoscopy due to the identification of high-risk groups from genetic and biomarker testing, genealogic and epidemiologic studies, and the increasing number of cancer survivors. An efficient surveillance program requires a cost-effective means for image-guided cancer detection and biopsy. A laser-based tethered-capsule endoscope with enhanced spectral imaging is introduced for unsedated surveillance of the lower esophagus. An ultrathin version of this same endoscope technology provides a 1.2-mm guidewire with imaging capability and cannula-style tools are proposed for image-guided biopsy. Advanced three-dimensional cell visualization techniques are described for increasing the sensitivity of early cancer diagnosis from hematoxylin-stained cells sampled from the pancreatic and biliary ducts.
Seibel
Eric J
EJ
Department of Mechanical Engineering, University of Washington, Seattle, 98195, USA. eseibel@u.washington.edu
Brentnall
Teresa A
TA
Dominitz
Jason A
JA
D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control; D053704:Capsule Endoscopy; D003362:Cost-Benefit Analysis; D016099:Endoscopy, Gastrointestinal / Q000191:economics / Q000379:methods / Q000592:standards; D005336:Fiber Optic Technology; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007413:Intestinal Mucosa / Q000166:cytology / Q000473:pathology; D008403:Mass Screening / Q000191:economics / Q000295:instrumentation / Q000379:methods; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology; D012680:Sensitivity and Specificity; D018571:Sentinel Surveillance