YB-1 translational control of epithelial-mesenchyme transition.
Transitions between epithelial and mesenchmal phenotypes play critical roles in normal development and cancer progression. In this issue of Cancer Cell, Evdokimova et al. demonstrate that YB-1 regulates epithelial-mesenchyme transition (EMT) by inducing cap-independent translation of mRNAs encoding EMT-promoting factors and suppressing cap-dependent translation of mRNAs encoding growth-promoting factors.
Mouneimne
Ghassan
G
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Brugge
Joan S
JS
D002454:Cell Differentiation / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D004847:Epithelial Cells / Q000166:cytology* / Q000502:physiology; D006801:Humans; D008648:Mesoderm / Q000166:cytology* / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology*; D014176:Protein Biosynthesis; D012315:RNA Caps / Q000502:physiology; D012333:RNA, Messenger / Q000502:physiology; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000502:physiology; D051840:Y-Box-Binding Protein 1
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D012315:RNA Caps; D012333:RNA, Messenger; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human