Semisynthesis and pharmacological activities of Tetrac analogs: angiogenesis modulators.
Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity.
The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA.
Alexandre
A
Bridoux
Huadong
H
Cui
Evgeny
E
Dyskin
Murat
M
Yalcin
Shaker A
SA
Mousa
D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D006454:Hemoglobins / Q000032:analysis; D051379:Mice; D013329:Structure-Activity Relationship; D013974:Thyroxine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D020533:Angiogenesis Inhibitors; D006454:Hemoglobins; D005346:Fibroblast Growth Factors; C011126:tetraiodothyroacetic acid; D013974:Thyroxine