Monocyte chemoattractant protein-1 (MCP-1): an overview.
Chemokines constitute a family of chemoattractant cytokines and are subdivided into four families on the basis of the number and spacing of the conserved cysteine residues in the N-terminus of the protein. Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled receptors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases. Migration of monocytes from the blood stream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as in response to inflammation. This review will discuss these biological processes and the structure and function of CCL2.
Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Satish L
SL
Deshmane
Sergey
S
Kremlev
Shohreh
S
Amini
Bassel E
BE
Sawaya
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism; D018932:Chemokine CCL2 / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002633:Chemotaxis / Q000276:immunology; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000276:immunology* / Q000378:metabolism; D015497:HIV-1 / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007167:Immunotherapy; D009000:Monocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011110:Polymorphism, Genetic; D054390:Receptors, CCR2 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D014652:Vascular Diseases / Q000276:immunology / Q000378:metabolism; D014774:Virulence
D018932:Chemokine CCL2; D054390:Receptors, CCR2