Glucocorticosteroids associated with a decreased risk of psychosis.
The hypothesis that chronic inflammation may play a role in psychosis receives increasing attention. In this study, we aim to investigate whether the use of steroidal anti-inflammatory drugs is associated with a decreased risk of psychosis.A longitudinal nested case-control study was performed investigating the association of glucocorticosteroid (GCS) consumption with a new diagnosis of a psychotic disorder. Significantly reduced odds ratios of 0.52 (95% confidence interval, 0.36-0.75) were found for GCS in men only (odds ratio in women, 0.84 [95% confidence interval, 0.590-1.20]). Similar risk reductions were present for the inhaled and systemic GCSs. A dose-response relationship was present. Our finding of an inverse relation between GCS consumption and new psychotic episodes may promote further research into inflammation in schizophrenia.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. W.Laan@umcutrecht.nl
Wijnand
W
Laan
Hugo
H
Smeets
Niek J
NJ
de Wit
René S
RS
Kahn
Diederick E
DE
Grobbee
Huibert
H
Burger
D000280:Administration, Inhalation; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016022:Case-Control Studies; D002908:Chronic Disease; D016208:Databases, Factual; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000188:drug therapy; D008137:Longitudinal Studies; D008297:Male; D016017:Odds Ratio; D011618:Psychotic Disorders / Q000209:etiology / Q000517:prevention & control*; D012737:Sex Factors
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids