Evaluating timing in spontaneously hypertensive and Wistar-Kyoto rats using the peak procedure.
A core deficit in timing may underlie the symptoms of attention-deficit/hyperactivity disorder (ADHD). Timing deficits have been observed in ADHD-diagnosed children but have yet to be fully explored in the spontaneously hypertensive rat (SHR), a purported model of ADHD. We asked whether SHRs demonstrate ADHD-like timing deficits using the peak procedure. Response rates across peak intervals were modeled using the sum of two Gaussian curves. Results showed that SHRs peaked earlier than Wistar-Kyotos based on 4s intervals that contained the individuals' maximum response rates but not based on model parameters. The strains showed approximately equal precision of timing based on Weber fractions derived from model parameters, a result that replicates previous findings and does not support the use of SHRs to model this aspect of ADHD.
Department of Psychology, Central Michigan University, Mount Pleasant, MI 48859, USA.
Andrew T
AT
Fox
Dennis J
DJ
Hand
Mark P
MP
Reilly
D000465:Algorithms; D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology; D006973:Hypertension / Q000235:genetics / Q000523:psychology*; D015233:Models, Statistical; D016011:Normal Distribution; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013998:Time Perception / Q000502:physiology*