Effects of acute hypoxia tests on blood markers in high-level endurance athletes.
The aim of this study was to determine the response of blood markers to acute hypoxia in high-level endurance athletes before training based on "living high-training low" model. Thirty endurance athletes performed a hypoxic cycling test and spent 3 h at rest in a simulated altitude of 3,000 m. At the end of the hypoxic cycling test, the quantity of the natural antisense transcript of HIF-1alpha mRNA (aHIF) transcript increased significantly (+37%, P = 0.024). After 3-h exposure, at a simulated altitude of 3,000 m, the amount of HIF-1alpha mRNA increased significantly (+57%, P = 0.012). Moreover, a large inter-subject range was observed in response to the hypoxic cycling test and to the prolonged hypoxic exposure: -133%/+79% and -82%/+653% for HIF-1alpha mRNA, 69%/+324% and -76%/+229% for aHIF. This study shows a large inter-variability of blood markers in elite athletes in response to acute hypoxic exposure corroborating previous observations made in other populations.
Mounier
Rémi
R
Laboratoire de Biologie des Activités Physiques et Sportives, Faculté de Médecine, 63000 Clermont-Ferrand, France. remimounier@voila.fr
Pialoux
Vincent
V
Schmitt
Laurent
L
Richalet
Jean-Paul
JP
Robach
Paul
P
Coudert
Jean
J
Clottes
Eric
E
Fellmann
Nicole
N
D000293:Adolescent; D000328:Adult; D001158:Arteries / Q000737:chemistry; D015415:Biomarkers / Q000097:blood*; D001774:Blood Chemical Analysis; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology*; D013177:Sports / Q000502:physiology*; D055815:Young Adult
D015415:Biomarkers; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit