Analgesic efficacy of lysine clonixinate, paracetamol and dipyrone in lower third molar extraction: a randomized controlled trial.
OBJECTIVE
The purpose of this study is to compare the analgesic effect of lysine clonixinate, paracetamol and dipyrone after lower third molar extraction.


METHODS
The sample consisted of 90 individuals with clinical indication for inferior third molar extraction. The mean age of the sample was 22.3 years (DP +/-2.5). The individuals received the medication in unidentified bottles along with the intake instructions. The postoperative pain parameters were measured according to the Visual Analogical Scale (VAS) and the data was evaluated using the Kruskal-Wallis Test and Friedman Test, with the latter used to test different time intervals for each one of the drugs.


RESULTS
The final sample consisted of 64 individuals, including 23 males (45.9%) and 41 females (64.1%) The mean age of the entire sample was 22.3 years (+/-2.5). The average length of the procedures was 33.9 minutes (+/-9.8). The distribution of mean values for this variable showed little variance for the different drugs (p=0.07).


CONCLUSIONS
Lysine Clonixinate did not show any substantial impact on the postoperative pain control when compared to other drugs.
Noronha
Vladimir-Reimar-Augusto-de Souza
VR
Dental School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Gurgel
Gladson-de Souza
GD
Alves
Luiz-César-Fonseca
LC
Noman-Ferreira
Luiz-Cláudio
LC
Mendonça
Lisette-Lobato
LL
Aguiar
Evandro-Guimarães de
EG
Abdo
Evandro-Neves
EN
D000082:Acetaminophen / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003002:Clonixin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004177:Dipyrone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008964:Molar, Third; D010149:Postoperative Pain / Q000517:prevention & control*; D014081:Tooth Extraction; D055815:Young Adult
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; C089163:lysine clonixinate; D000082:Acetaminophen; D004177:Dipyrone; D008239:Lysine; D003002:Clonixin