Identification of Hsp70 modulators through modeling of the substrate binding domain.
The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described. The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology.
Haney
Conor M
CM
Department of Pharmacy, University of Pittsburgh, Pittsburgh, USA.
Schneider
Corinne
C
Beck
Barbara
B
Brodsky
Jeffrey L
JL
Dömling
Alexander
A
D000595:Amino Acid Sequence; D001665:Binding Sites; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry* / Q000378:metabolism; D008956:Models, Chemical; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011485:Protein Binding; D017434:Protein Structure, Tertiary
D018840:HSP70 Heat-Shock Proteins; D010455:Peptides