No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples.
Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts-one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)-and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.
Lind
Penelope A
PA
Genetic Epidemiology Unit, PO Royal Brisbane Hospital, Brisbane, QLD, 4029, Australia. penelope.lind@qimr.edu.au
Luciano
Michelle
M
Horan
Michael A
MA
Marioni
Riccardo E
RE
Wright
Margaret J
MJ
Bates
Timothy C
TC
Rabbitt
Patrick
P
Harris
Sarah E
SE
Davidson
Yvonne
Y
Deary
Ian J
IJ
Gibbons
Linda
L
Pickles
Andrew
A
Ollier
William
W
Pendleton
Neil
N
Price
Jackie F
JF
Payton
Antony
A
Martin
Nicholas G
NG
D000368:Aged; D000369:Aged, 80 and over; D001315:Australia; D003071:Cognition / Q000502:physiology*; D015331:Cohort Studies; D004739:England; D005192:Family Health; D005260:Female; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D007360:Intelligence / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D043585:Receptor, Muscarinic M2 / Q000235:genetics*; D012606:Scotland
C487078:CHRM2 protein, human; D005819:Genetic Markers; D043585:Receptor, Muscarinic M2