Palladium-catalyzed cyanation of carbon-carbon triple bonds under aerobic conditions.
Essential oxygen: The title transformation involves two different modes of cyanation, syn and anti cyanopalladation, as the key steps in this catalytic reaction. These processes enable successful dicyanative cyclization of diyne and enyne derivatives (see scheme).
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, Japan. arai@p.chiba-u.ac.jp
Shigeru
S
Arai
Takashi
T
Sato
Yuka
Y
Koike
Michino
M
Hayashi
Atsushi
A
Nishida
D000388:Air; D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D010165:Palladium / Q000737:chemistry*
D000480:Alkynes; D003486:Cyanides; D010165:Palladium