Classically conditioned fear responses are preserved following unilateral temporal lobectomy in humans when concurrent US-expectancy ratings are used.
Previous lesion studies demonstrate that patients who underwent a unilateral temporal lobe resection show impaired skin conductance responding (SCR) to aversively conditioned stimuli. The aim of the current lesion study was to examine whether the amygdala is also critically involved in differential SCR during a more explicit form of fear learning. A simple discrimination task was presented to a unilaterally amygdala-damaged patient group and a control group, in which one neutral stimulus was always followed by an electric shock (CS+), whereas a second stimulus always appeared alone (CS-). To direct attention towards the stimulus contingencies, participants were asked to predict the occurrence of the shock continuously throughout the whole task. The results revealed that patients and controls rapidly acquired contingency knowledge as measured by the online US-expectancy ratings. Crucially, both test groups showed differential SCRs during CS+ and CS- trials. Thus, contrary to earlier findings, robust conditioned SCRs can be obtained in patients with unilateral temporal lobe resection as long as they are able to acquire explicit stimulus contingency knowledge. The two-level account of Ohman and Mineka [Ohman, A., & Mineka, S. (2001). Fears, phobias, and preparedness: Toward an evolved module of fear and fear learning. Psychological Review, 108, 483-522] is proposed in order to explain the diverse lesion data obtained so far.
Coppens
Evelien
E
Department of Psychology, University of Leuven, Leuven, Belgium. Evelien.Coppens@psy.kuleuven.be
Spruyt
Adriaan
A
Vandenbulcke
Mathieu
M
Van Paesschen
Wim
W
Vansteenwegen
Debora
D
D000679:Amygdala / Q000503:physiopathology*; D000704:Analysis of Variance; D001930:Brain Injuries / Q000473:pathology / Q000601:surgery; D003214:Conditioning, Classical; D004192:Discrimination, Psychological / Q000502:physiology; D005239:Fear; D007839:Functional Laterality / Q000502:physiology*; D005712:Galvanic Skin Response / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009862:Online Systems; D010147:Pain Measurement; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D011594:Psychometrics; D011612:Psychosurgery / Q000379:methods*; D013702:Temporal Lobe / Q000601:surgery*