[Osteoimmunology update--from bench to bedside].
The immune and skeletal systems share various molecules including cytokines, signaling molecules, transcription factors and membrane receptors, while immune cells are maintained in the bone marrow, which provides a physiological space for mutual interaction. In rheumatoid arthritis, synovium is the active site for the interplay between the immune and bone cells, the study of which accelerated the interdisciplinary field of osteoimmunology. This emerging field will be of great importance to better understand how antirheumatic drugs work and to develop new therapeutic strategies for rheumatic diseases.
Takayanagi
Hiroshi
H
Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy; D001842:Bone and Bones / Q000276:immunology*; D056657:Cathepsin K; D002403:Cathepsins / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics; D015195:Drug Design; D006801:Humans; D050778:NFATC Transcription Factors; D010010:Osteoclasts / Q000166:cytology; D053245:RANK Ligand / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes
D050778:NFATC Transcription Factors; C494003:NFATC1 protein, human; D053245:RANK Ligand; D002403:Cathepsins; C534130:CTSK protein, human; D056657:Cathepsin K