Long-time course of protease-activated receptor-1 expression after intracerebral hemorrhage in rats.
Thrombin plays an important role in brain injuries associated with intracerebral hemorrhage (ICH). The protease-activated receptor (PAR)-1 is responsible for the vast majority of the thrombin's cellular activation functions. We tested the hypothesis that thrombin-induced brain damage after ICH, at least in part, is mediated by PAR-1. We report that there are significant differences between PAR-1 positive cell number and PAR-1 mRNA absorbance ratio between ICH model group (at 6h, 24h, 3 d, 7 d and 14 d) and normal group (P<0.05). These results suggest that the long-time course of PAR-1 expression may be partly involved in the mechanism of thrombin-induced brain damage after ICH.
Zheng
Guo-Qing
GQ
Center of Neurology and Rehabilitation, The Second Affiliated Hospital of Wenzhou Medical College, 109 Xueyuan Road, Wenzhou, Zhejiang 325027, China. gq zheng@sohu.com
Wang
Xiao-Tong
XT
Wang
Xiu-Min
XM
Gao
Ran-Ran
RR
Zeng
Xiao-Lin
XL
Fu
Xiao-Lei
XL
Wang
Yan
Y
D000818:Animals; D002452:Cell Count; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000378:metabolism*; D054022:Cerebrum / Q000378:metabolism*; D017364:Collagenases / Q000008:administration & dosage; D004587:Electrophoresis, Agar Gel; D006429:Hemiplegia / Q000209:etiology; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D044463:Receptor, PAR-1 / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012720:Severity of Illness Index; D013917:Thrombin / Q000633:toxicity; D013997:Time Factors
D012333:RNA, Messenger; D044463:Receptor, PAR-1; D013917:Thrombin; D017364:Collagenases