Comparison of the toxicokinetic behavior of perfluorohexanoic acid (PFHxA) and nonafluorobutane-1-sulfonic acid (PFBS) in cynomolgus monkeys and rats.
The toxicokinetics of perfluorohexanoic acid (PFHxA) and nonafluoro-1-butanesulfonic acid (PFBS) were evaluated in Sprague-Dawley rats and cynomolgus monkeys. Systemic exposure to PFHxA was lower than for PFBS following single equivalent intravenous or oral (rat only) doses. Serum clearance was more rapid for PFHxA than for PFBS. In rats, exposure to PFHxA and PFBS was up to 8-fold (intravenous) and 4-fold (oral) higher for males than females and serum clearance of PFHxA and PFBS was more rapid in females than males; however, there was no appreciable difference in the extent or rate of urinary elimination between compounds or genders. There were no apparent differences between genders in the serum half-life for PFHxA following 26 days of repeated oral dosing in rats; exposure decreased upon repeated dosing.
WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805-9281, United States.
Christopher P
CP
Chengelis
WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805-9281, United States. Electronic address: jkirkpatrick@wilresearch.com.
Jeannie B
JB
Kirkpatrick
WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805-9281, United States.
Nichole R
NR
Myers
AGC Chemicals, Asahi Glass Company, Ltd., Japan.
Motoki
M
Shinohara
WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805-9281, United States.
Philip L
PL
Stetson
WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805-9281, United States.
Daniel W
DW
Sved
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001774:Blood Chemical Analysis; D002208:Caproates / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D006207:Half-Life; D007275:Injections, Intravenous; D008252:Macaca fascicularis; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D013451:Sulfonic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D016482:Urinalysis
D002208:Caproates; D005466:Fluorocarbons; D013451:Sulfonic Acids; C542778:nonafluorobutane-1-sulfonic acid; C479228:perfluorohexanoic acid