Triggered release of an active peptide conjugate from a DNA device by an orally administrable small molecule.
A real tonic: In a conceptually new approach to controlled release, the natural daily insulin profile in response to three meals is mimicked (see graph) with release of an insulin conjugate from a matrix, triggered by quinine, a component of tonic water.
Taylor
Steven K
SK
Department of Medicine, Division of Experimental Therapeutics, The NSF Center for Molecular Cybernetics, Columbia University, 630 W. 168th St., Box 84, New York, NY 10032, USA. st2171@columbia.edu
Pei
Renjun
R
Moon
Byoung C
BC
Damera
Srikanth
S
Shen
Aihua
A
Stojanovic
Milan N
MN
D000284:Administration, Oral; D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000737:chemistry; D007328:Insulin / Q000008:administration & dosage* / Q000737:chemistry; D008969:Molecular Sequence Data; D011803:Quinine / Q000737:chemistry*; D020349:Surface Plasmon Resonance
D004337:Drug Carriers; D007004:Hypoglycemic Agents; D007328:Insulin; D004247:DNA; D011803:Quinine