Mesenchymal stem cells in the induction of transplantation tolerance.
Mesenchymal stem cells directly suppress ongoing immune responses. Through production of toleragenic cytokines, inhibition of lymphocyte proliferation, delivery of reparative and protective signals after reperfusion injury, and facilitation of hematopoietic chimerism, these cells demonstrate a wide-ranging potential for the development of multifaceted toleragenic strategies after transplantation.
Bartholomew
Amelia
A
Department of Surgery, University of Illinois-Chicago, Chicago, IL 60612, USA. ambart@uic.edu
Polchert
David
D
Szilagyi
Erzsebet
E
Douglas
G W
GW
Kenyon
Norma
N
D001402:B-Lymphocytes / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018183:Transplantation Chimera; D023001:Transplantation Tolerance / Q000276:immunology