Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm.
Chronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization.
Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01605, USA.
Guilin
G
Tang
Lesley J
LJ
Woods
Sa A
SA
Wang
Doreen
D
Brettler
Mary
M
Andersen
Patricia M
PM
Miron
Liberto
L
Pechet
Bruce A
BA
Woda
Suyang
S
Hao
D000369:Aged, 80 and over; D001491:Basophils / Q000473:pathology*; D001854:Bone Marrow Cells / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D002881:Chromosomes, Human, Pair 12; D002895:Chromosomes, Human, Pair 5; D005434:Flow Cytometry; D015321:Gene Rearrangement; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D015466:Leukemia, Myeloid, Chronic-Phase / Q000235:genetics / Q000473:pathology*; D008297:Male; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics; D000097764:ETS Translocation Variant 6 Protein
D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D000097764:ETS Translocation Variant 6 Protein