Diphosphoinositol polyphosphates: metabolic messengers?
The diphosphoinositol polyphosphates ("inositol pyrophosphates") are a specialized subgroup of the inositol phosphate signaling family. This review proposes that many of the current data concerning the metabolic turnover and biological effects of the diphosphoinositol polyphosphates are linked by a common theme: these polyphosphates act as metabolic messengers. This review will also discuss the latest proposals concerning possible molecular mechanisms of action of this intriguing class of molecules.
Inositide Signaling Group, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. shears@niehs.nih.gov
Stephen B
SB
Shears
D000818:Animals; D006801:Humans; D007295:Inositol Phosphates / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D011122:Polyphosphates / Q000378:metabolism*; D015398:Signal Transduction
D007295:Inositol Phosphates; D011122:Polyphosphates