Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice.
The main aim of this study was to elucidate whether thermosensitive transient receptor potential channels (thermoTRPs) play a role in controlling autonomic thermoregulation. We investigated whether the activation of certain thermoTRPs, TRPV1, TRPV3, TRPM8, and TRPA1, would induce autonomic thermoregulation by administering chemical agonists derived from spices and aroma chemicals of these channels to anesthetized mice. We discovered the following: Capsaicin, a TRPV1 agonist, enhanced thermogenesis and heat diffusion; thymol and ethyl vanillin, TRPV3 agonists, did not have any effect on thermogenesis or heat diffusion; menthol and 1,8-cineole, TRPM8 agonists, enhanced thermogenesis; and allyl isothiocyanate and cinnamaldehyde, TRPA1 agonists, enhanced thermogenesis and inhibited heat diffusion. These results suggest that these thermoTRP agonists derived from spices and aroma chemicals modulate autonomic thermoregulation, except for TRPV3 agonists. Our findings suggest the possibility that each thermoTRP is a key sensor inducing reasonable autonomic thermoregulation according to its own activated temperature range.
Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Yukiko
Y
Masamoto
Fuminori
F
Kawabata
Tohru
T
Fushiki
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004058:Diffusion / Q000187:drug effects; D006358:Hot Temperature; D007473:Ion Channels / Q000819:agonists*; D008297:Male; D049990:Membrane Transport Modulators / Q000008:administration & dosage* / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013270:Stomach; D000074025:TRPA1 Cation Channel; D050053:TRPM Cation Channels / Q000819:agonists; D050916:TRPV Cation Channels / Q000819:agonists; D022722:Thermogenesis / Q000187:drug effects; D050051:Transient Receptor Potential Channels / Q000819:agonists
D007473:Ion Channels; D049990:Membrane Transport Modulators; D000074025:TRPA1 Cation Channel; D050053:TRPM Cation Channels; C492297:TRPM8 protein, mouse; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse; D050051:Transient Receptor Potential Channels; C475685:Trpa1 protein, mouse; C486760:Trpv3 protein, mouse