Dose-response relationship between periodontal inflamed surface area and HbA1c in type 2 diabetics.
BACKGROUND
A dose-response relationship between the amount of inflamed periodontal tissue and HbA1c level, might be indicative for a causal association between periodontitis and type 2 diabetes.


OBJECTIVE
To assess a dose-response relationship between the periodontal inflamed surface area (PISA), as a measure of the amount of inflamed periodontal tissue, and HbA1c levels in type 2 diabetics.


METHODS
Forty consecutive dentate type 2 diabetics attending their general practitioner for regular check-up, underwent full-mouth probing pocket depth and bleeding on probing assessment. From these data PISA was calculated. HbA1c levels were retrieved from patients' medical files. The dose-response relationship between PISA and HbA1c levels was assessed using multiple linear regression analyses, controlling for factors that might influence PISA or HbA1c levels.


RESULTS
The higher the PISA of type 2 diabetics was, the higher their HbA1c levels were. On a group level, an increase of PISA with 333 mm(2) was associated with a 1.0 percentage point increase of HbA1c, independent of the influence of other factors.


CONCLUSIONS
On a group level, there is a dose-response relationship between PISA and HbA1c in type 2 diabetics. This might be an indication of a causal relationship between type 2 diabetes and periodontitis.
Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. w.nesse@kchir.umcg.nl
Willem
W
Nesse
Annemiek
A
Linde
Frank
F
Abbas
Frederik Karst Lucien
FK
Spijkervet
Pieter Ubele
PU
Dijkstra
Eric Carl
EC
de Brabander
Izzy
I
Gerstenbluth
Arjan
A
Vissink
D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood / Q000150:complications; D010512:Periodontal Index; D010518:Periodontitis / Q000097:blood / Q000150:complications* / Q000473:pathology*
D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human