[Electrophysiological changes in patients with early stages of Alzheimer's disease].
OBJECTIVE
An evaluation of retinal and optic nerve bioelectrical function in patients with early stages of Alzheimer's disease.


METHODS
30 eyes of 15 patients in the early stage of Alzheimer's disease with normal eye fundus appearance were analysed. Electrophysiological tests of the retina and optic nerve (FVEP, PVEP, PERG, ERG) were performed according to ISCEV standards.


RESULTS
The dysfunction of the retina and optic nerve was observed. The most common abnormalities were noted in PVEP test (latency increase of P100-wave--36.7% eyes) and in PERG test (latency increase of P50-wave--33.3% eyes).


CONCLUSIONS
In patients with early stage of Alzheimer's disease there is a dysfunction of the retina and optic nerve, which can be detected by electrophysiological tests, even in patients with normal eye fundus.
Katedra i Klinika Okulistyki Pomorskiej Akademii Medycznej w Szczecinie al. Powstańców Wlkp. 72, 70-111 Szczecin.
Kamila
K
Krasodomska
Wojciech
W
Lubiński
Andrzej
A
Potemkowski
Krystyna
K
Honczarenko
Monika
M
Gołab-Janowska
Marcin
M
Ratajczak
Zbigniew
Z
Szych
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D004568:Electrodiagnosis; D004594:Electrophysiology; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D009901:Optic Nerve Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D012164:Retinal Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology