Granulocyte-colony stimulating factor-producing pancreatic adenosquamous carcinoma showing aggressive clinical course.
Herein, we encountered an 89-year-old woman with pancreatic cancer who presented with fever without infective focus, leukocytosis of 45,860 /microL, and elevation of serum granulocyte-colony stimulating factor (G-CSF). The patient could not receive any curative therapy due to an extremely aggressive clinical course. Specimens taken at necropsy revealed an adenosquamous carcinoma positive for G-CSF by immunohistochemistry; it was only the second reported case to date. She was finally diagnosed with G-CSF-producing pancreatic cancer. In light of the above, clinicians should consider the presence of G-CSF-producing tumors, including pancreatic cancer, when presented with patients showing leukocytosis of unknown origin and fever without infective focus.
Department of Internal Medicine, Matsumoto Medical Center.
Satoru
S
Joshita
Koh
K
Nakazawa
Yukiko
Y
Sugiyama
Atsushi
A
Kamijo
Kiyoshi
K
Matsubayashi
Hideharu
H
Miyabayashi
Kiyoshi
K
Furuta
Kiyoshi
K
Kitano
Shigeyuki
S
Kawa
D000369:Aged, 80 and over; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D007964:Leukocytosis / Q000175:diagnosis / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology / Q000556:secondary; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism
D016179:Granulocyte Colony-Stimulating Factor