[Asbestos-related cancer risk in the presence of asbestosis or pleural plaques].
BACKGROUND
The relationships between benign asbestos-related diseases (asbestosis and pleural plaques) and thoracic cancers are still debated. The aim of this paper is to analyse epidemiological data which investigate this topic.


BACKGROUND
Published studies show that there is a significant relationship between occupational exposure to asbestos and lung cancer risk, even in the absence of abnormalities consistent with asbestos exposure on postero-anterior chest x-ray. In subjects with occupational exposure to asbestos, an increased risk of lung cancer and pleural mesothelioma is observed in subjects with pleural plaques on chest x-ray, in comparison with the general population. In exposed subjects with similar cumulative exposure to asbestos, it is not demonstrated that pleural plaques are associated with an increased risk of lung cancer or pleural mesothelioma.


CONCLUSIONS
All the analysed studies are only based on radiographic data. Their results must be confirmed by additional studies including a rigorous evaluation of the cumulative exposure to asbestos and chest CT-scans.


CONCLUSIONS
In the present state of knowledge, isolated pleural plaques do not justify specific medical surveillance, as compared to that required by the mere estimated cumulative exposure to asbestos.
Unité de pathologie professionnelle, AP-HP, Hôpital Raymond-Poincaré, Garches, France. jacques.ameille@rpc.aphp.fr
J
J
Ameille
P
P
Brochard
M
M
Letourneux
C
C
Paris
J-C
JC
Pairon
D001195:Asbestosis / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D008654:Mesothelioma / Q000209:etiology*; D016273:Occupational Exposure; D010995:Pleural Diseases / Q000209:etiology*; D018570:Risk Assessment