Modulating the hybridization property of PNA with a peptoid-like side chain.
Modification on the gamma-N of the PNA backbone yielded a PNA analogue with a peptoid-like side chain. We found that the length of the side chain was important in influencing the hybridization affinity of the modified PNA.
Lu
Xiao-Wei
XW
Division of Chemical Biology and Biotechnology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
Zeng
Yun
Y
Liu
Chuan-Fa
CF
D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D034444:Peptoids / Q000737:chemistry*; D012689:Sequence Homology, Nucleic Acid; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D020135:Peptide Nucleic Acids; D034444:Peptoids; D009584:Nitrogen