Activity of daptomycin against multiresistant clinical isolates of Staphylococcus aureus and Streptococcus agalactiae.
The activity of daptomycin against 141 Staphylococcus aureus and 63 Streptococcus agalactiae isolates was assessed. The isolates were previously characterized and showed resistance to the antibiotics normally used against gram-positive cocci. Daptomycin was active against 100% of the isolates (minimum inhibitory concentration [MIC(90)] = 0.5 microg/ml, for both species). This antibiotic shows good in vitro activity; therefore, it is an excellent therapeutic alternative against these isolates.
Department of Microbiology, School of Medicine, University of Granada, Granada, Spain.
Antonio
A
Sorlozano
José
J
Gutiérrez
Juan
J
Roman
Jose
J
Liebana
Gonzalo
G
Piedrola
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D017576:Daptomycin / Q000494:pharmacology* / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D017576:Daptomycin