[Nimodipine and experimental combined disorders of cerebral and coronary circulation].
The influence of nimodipine on the cerebral circulation of rats under conditions of global transient cerebral ischemia, myocardial ischemia, and combined disorders of cerebral and coronary circulation was experimentally studied in rats, in comparison to the intact and sham operated animals. It is shown that nimodipine (0.03 mg/kg) enhances circulation in the parietal region of the cerebral cortex to the same extent in both intact rats and those after global transient cerebral ischemia. Under conditions of experimental myocardial infarction, the cerebrovascular effect of nimodipine was significantly decreased in comparison to that in intact and sham operated animals. In contrast to intact and sham operated rats and the rats with myocardial infarction, there were no signs of cerebrovascular activity of nimodipine in animals with combined disorders of coronary and cerebral circulation. A new approach to the search for and investigation of pharmacological agents for the treatment of combined disturbances of cerebral and cardiac circulation is proposed.
Mirzoian
R S
RS
Khaĭlov
N A
NA
Tsorin
I B
IB
Gan'shina
T S
TS
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D004569:Electroencephalography; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D009553:Nimodipine / Q000627:therapeutic use*; D051381:Rats; D014665:Vasodilator Agents / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D009553:Nimodipine