Drug delivery for in vitro fertilization: rationale, current strategies and challenges.
In vitro fertilization has experienced phenomenal progress in the last thirty years and awaits the additional refinement and enhancement of medication delivery systems. Opportunity exists for the novel delivery of gonadotropins, progesterone and other adjuvants. This review highlights the rationale for various medications, present delivery methods and introduces the status of novel ideas and possibilities.
Department of Obstetrics and Gynecology, Health Science Center, University of Utah, 30 North 1900 East, Suite 2B200, School of Medicine, Salt Lake City, Utah 84132, USA.
Margit M
MM
Janát-Amsbury
Kavita M
KM
Gupta
Caroline D
CD
Kablitz
C Matthew
CM
Peterson
D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006062:Gonadotropins / Q000008:administration & dosage*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D008183:Luteal Phase / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage*
D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone