Bisphenol A: Perinatal exposure and body weight.
Bisphenol A (BPA) is a component of polycarbonate and other plastics including resins that line food and beverage containers. BPA is known to leach from products in contact with food and drink, and is therefore thought to be routinely ingested. In a recent cross sectional study, BPA was detected in urine samples from 92.6% of the US population examined. The potential for BPA to influence body weight is suggested by in vitro studies demonstrating effects of BPA on adipocyte differentiation, lipid accumulation, glucose transport and adiponectin secretion. Data from in vivo studies have revealed dose-dependent and sex dependent effects on body weight in rodents exposed perinatally to BPA. The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed.
Rubin
Beverly S
BS
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, United States. beverly.rubin@tufts.edu
Soto
Ana M
AM
D017667:Adipocytes / Q000187:drug effects; D000818:Animals; D001559:Benzhydryl Compounds; D001835:Body Weight / Q000187:drug effects*; D004054:Diethylstilbestrol / Q000737:chemistry; D052244:Endocrine Disruptors / Q000737:chemistry / Q000494:pharmacology*; D004958:Estradiol / Q000737:chemistry / Q000378:metabolism; D004968:Estrogens, Non-Steroidal / Q000737:chemistry; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D018811:Maternal Exposure; D015394:Molecular Structure; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011960:Receptors, Estrogen / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004054:Diethylstilbestrol; D052244:Endocrine Disruptors; D004958:Estradiol; D004968:Estrogens, Non-Steroidal; D005947:Glucose; D047492:Peroxisome Proliferator-Activated Receptors; D010636:Phenols; D011960:Receptors, Estrogen; D013963:Thyroid Hormones; C490917:ESRRG protein, human; C006780:bisphenol A; D000098826:Bisphenol A Compounds