Correlation among soluble markers and severity of disease in non-diabetic subjects with pre-mature coronary artery disease.
Studies are lacking in literature, which demonstrate the cumulative impact of certain soluble markers in predicting the severity of CAD. Serum hsCRP, MMP-9, TIMP-1 and sRAGE levels were measured in non-diabetic 100 angiographically proven CAD patients (Group I) and 40 non-diabetic subjects with coronary risk factors and without any lesions (Group II). Increased levels of serum hsCRP, MMP-9, TIMP-1 and decreased levels of sRAGE were observed in Group I as compared to Group II. Gensini score, a measure for severity of CAD was found to be positively correlated with serum hsCRP, MMP-9, TIMP-1 and negatively with sRAGE. Multivariate analysis revealed serum MMP-9, hsCRP, sRAGE and family history as predictors of severity of CAD with a cumulative sensitivity and specificity of 92% and 82%, respectively. Cumulative impact of these soluble markers, in addition to the established markers will contribute to improve the predictive value for the assessment of disease severity.
Mahajan
Nitin
N
Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research (PGIMER), Research Block 'B', Chandigarh, 160012, India.
Malik
Namita
N
Bahl
Ajay
A
Sharma
Yashpaul
Y
Dhawan
Veena
V
D000328:Adult; D017668:Age of Onset; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D011237:Predictive Value of Tests; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012995:Solubility; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D055815:Young Adult
D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D019715:Tissue Inhibitor of Metalloproteinase-1; D002097:C-Reactive Protein; D020780:Matrix Metalloproteinase 9