Subcutaneous leiomyosarcoma in an adrenomedullin heterozygous mouse.
The present study reports a case of a 5-month-old female adrenomedullin (AM) heterozygous (+/-) mouse that presented a mass of leiomyosarcoma found in the right shoulder girdle region. The neoplastic mass extended to the sternal region and showed hemorrhages, congestion and necrotic foci. The excised tumor with a diameter of 2.5cm was firm, ill-demarcated and had focally infiltrated the surrounding muscles. The cut surface was homogeneously whitish with multi-focal reddish lesions. Microscopically, the tumor composed of variable fascicles of spindle-shaped cells with pleomorphic and cigar-shaped nuclei. The nuclei were round and elongated. Metastasis of tumor cell to skeletal muscle was frequently observed. Immunohistochemically, desmin, vimentin and alpha-smooth muscle actin (alpha-SMA) were demonstrated in neoplastic cells but tumor cells were negative for cytokeratin (CK) and S-100. Based on gross finding, microscopical examination and immunohistochemistry, the present case was diagnosed as a subcutaneous leiomyosarcoma.
College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea.
Jin-Kyu
JK
Park
Il-Hwa
IH
Hong
Moon-Jung
MJ
Goo
Mi-Ran
MR
Ki
Kyung-Sook
KS
Hong
Ok-Kyung
OK
Hwang
Jung-Youn
JY
Han
Ae-Ri
AR
Ji
Se-Il
SI
Park
Kyu-Shik
KS
Jeong
D053607:Adrenomedullin / Q000235:genetics*; D000818:Animals; D005260:Female; D006579:Heterozygote; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D051379:Mice; D008810:Mice, Inbred C57BL; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D040521:Subcutaneous Tissue / Q000473:pathology
D053607:Adrenomedullin