Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}.
Micellar mannose nanoparticles were constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]} with fluorophores or quenchers doped into the hydrophobic inner cores, allowing the direct monitoring of multivalent lectin-glycan interactions. The mannose-displaying nanoparticles bind Con A and sperm surface lectins with high affinity, suggesting their broad utility for modulating protein-carbohydrate interaction mediated cell surface biology.
Department of Chemistry, College of Chemistry and Chemical Engineering, and The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, 361005, P. R. China.
Rongmin
R
Su
Lei
L
Li
Xiaoping
X
Chen
Jiahuai
J
Han
Shoufa
S
Han
D003460:Crystallization; D005459:Fluorides / Q000737:chemistry; D006801:Humans; D008297:Male; D008299:Maleic Anhydrides / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry*; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry; D013094:Spermatozoa / Q000737:chemistry; D020058:Styrene / Q000737:chemistry*
D008299:Maleic Anhydrides; D008823:Micelles; D010710:Phosphates; C012980:fluorophosphate; D020058:Styrene; D008358:Mannose; D005459:Fluorides