An efficient one-pot copper-catalyzed approach to isoquinolin-1(2H)-one derivatives.
A simple and efficient copper-catalyzed method for synthesis of 3,4-disubstituted isoquinolin-1(2H)-one derivatives via cascade reactions of substituted 2-halobenzamides with beta-keto esters under mild conditions has been developed, and the method has economical and practical advantages.
Wang
Feng
F
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Liu
Hongxia
H
Fu
Hua
H
Jiang
Yuyang
Y
Zhao
Yufen
Y
D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D001549:Benzamides; D006846:Hydrocarbons, Halogenated; D007546:Isoquinolines; D003300:Copper