Molecular and biochemical pharmacology of the histamine H4 receptor.
The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H4 receptor.
Department of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, VU University Amsterdam, Amsterdam, The Netherlands. leurs@few.vu.nl
Rob
R
Leurs
Paul L
PL
Chazot
Fiona C
FC
Shenton
Herman D
HD
Lim
Iwan J P
IJ
de Esch
D000818:Animals; D001665:Binding Sites; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D010802:Phylogeny; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D011968:Receptors, Histamine / Q000235:genetics / Q000502:physiology; D000074040:Receptors, Histamine H4; D013045:Species Specificity
C418607:HRH4 protein, human; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4