Hepatitis G virus infection in multitransfused Egyptian children.
The purpose of this study was to identify the magnitude of the hepatitis G virus infection in 33 multitransfused cases and 20 matched controls. All were tested for liver biochemical profile, HBsAg, HCV-antibody, HGV-RNA, and antibody to envelop protein E(2). HGV was detected alone in 61% of the multitransfused cases and 15% of the controls. Hepatitis markers were negative in 21% of cases versus 70% of controls. HGV envelope antibody was detected in 12% of cases, and none of controls. Mean values of transaminases in HGV positives and negatives showed no significant differences. HGV infection is highly prevalent in Egyptian children with no impact in infected cases.
Department of Pediatrics, Cairo University, Cairo, Egypt. ksalama2@yahoo.com
Khaled Mohamed
KM
Salama
Osima El-Sayed
Oel-S
Selim
D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D001803:Blood Transfusion; D002648:Child; D004534:Egypt / Q000453:epidemiology; D005260:Female; D018178:Flaviviridae Infections / Q000201:enzymology / Q000453:epidemiology*; D029407:GB virus C / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000201:enzymology / Q000453:epidemiology*; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000821:virology; D008297:Male; D015995:Prevalence; D000637:Transaminases / Q000032:analysis
D000914:Antibodies, Viral; D000956:Antigens, Viral; D000637:Transaminases