The effect of cyanoacrylate in esophagocutaneous leakages occurring after esophageal anastomosis.
OBJECTIVE
Esophageal leakage (EL) continues to be a challenging pediatric surgical problem. The aim of this study was to investigate the effect of cyanoacrylate (Cy) in EL followed esophageal repair (ER).


METHODS
Twelve rabbits were divided into control (C) and leakage (L) groups. A 1cm-length transverse esophageal incision at the level of the cervical region was made. In both groups, feeding was started orally 24h after the surgery for leakage creation. On postoperative day 7, primary repair was carried out in the C group and Cy instillation was performed in the L group. Esophagographic analysis was carried out on postoperative day 9 and the animals were fed orally on the same day on the condition that there was no esophageal leakage. The rabbits were sacrificed to measure diameters of the OR line, bursting pressure (BP), and hydroxyproline (HP) levels in the repaired cervical esophageal segment (RCES) 2 months later.


RESULTS
The values of BP and HP in the C group were significantly higher than those in the L group. The diameters of the OR line in the L group were significantly greater compared to those in the C group.


CONCLUSIONS
Cy glue instillation seems to be the ideal treatment for esophageal anastomosis leakages as shown by increased diameters of the OR line and decreased HP levels.
Yurtçu
Müslim
M
Department of Pediatric Surgery, Meram Medical School of Selcuk University, Konya, Turkey. Muslimyurtcu@hotmail.com
Arbag
Hamdi
H
Cağlayan
Osman
O
Abasiyanik
Adnan
A
Oz
Mehmet
M
D000714:Anastomosis, Surgical / Q000009:adverse effects*; D000818:Animals; D017577:Cutaneous Fistula / Q000188:drug therapy* / Q000209:etiology; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004937:Esophageal Fistula / Q000188:drug therapy* / Q000209:etiology; D004947:Esophagus / Q000187:drug effects / Q000601:surgery*; D006801:Humans; D006909:Hydroxyproline / Q000187:drug effects; D011817:Rabbits; D014014:Tissue Adhesives / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects
D003487:Cyanoacrylates; D014014:Tissue Adhesives; D006909:Hydroxyproline