Reduction of amphotericin B-induced renal tubular apoptosis by N-acetylcysteine.
The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-acetylcysteine (NAC) in a murine model was evaluated. Four groups of rats were treated with AmB for 5 days, and each group concomitantly received two doses of 30, 60, or 120 mg of NAC/kg of body weight/day or sterile water for 5 days. Groups that received concomitant NAC at any dose had significantly decreased levels of apoptosis compared to that in animals receiving AmB only (48.8% versus 27.4, 23.6, or 23.5%, respectively; P < 0.001).
Odabasi
Z
Z
Marmara University Hospital, Department of Infectious Diseases, Tophanelioglu caddesi, Altunizade, Istanbul, Turkey. zekaver@marmara.edu.tr
Karaalp
A
A
Cermik
H
H
Mohr
J
J
Tigen
E T
ET
Koc
M
M
Korten
V
V
D000111:Acetylcysteine / Q000494:pharmacology*; D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D007668:Kidney / Q000166:cytology / Q000187:drug effects*; D007684:Kidney Tubules / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D000666:Amphotericin B; D000111:Acetylcysteine