Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro.
See you later amyloid beta: A screen of a small library of oxime oligomers with an HTS fluorescence assay for amyloid fibril inhibition and subsequent investigation by atomic force microscopy revealed two new micromolar inhibitors of amyloid fibril formation. These new inhibitors have IC(50) values in the 10 microM range.
Département Chimie Moléculaire, UMR 5250, ICMG-FR 2607, Université Joseph Fourier, 301 rue de la Chimie, BP 53, 38041 Grenoble Cedex 9, France.
Gunnar T
GT
Dolphin
Olivier
O
Renaudet
Myriam
M
Ouberai
Pascal
P
Dumy
Julian
J
Garcia
Jean-Louis
JL
Reymond
D000544:Alzheimer Disease / Q000378:metabolism; D000682:Amyloid / Q000037:antagonists & inhibitors / Q000187:drug effects* / Q000648:ultrastructure; D016229:Amyloid beta-Peptides / Q000187:drug effects*; D006801:Humans; D018625:Microscopy, Atomic Force; D010091:Oximes / Q000737:chemistry* / Q000494:pharmacology; D010455:Peptides / Q000187:drug effects; D054852:Small Molecule Libraries; D013050:Spectrometry, Fluorescence
D000682:Amyloid; D016229:Amyloid beta-Peptides; D010091:Oximes; D010455:Peptides; D054852:Small Molecule Libraries