Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis.
Despite considerable progress in understanding the function of peroxiredoxin (Prx) in cancer, its expression patterns have not been extensively studied in response to cervical carcinogenesis. We evaluated the expression of Prx isoforms in normal tissue, cervical intraepithelial neoplasia (CIN1, CIN2, and CIN3), and cervical cancer. We found strong pattern of increased Prx II and III immunostaining with increasing severity of the lesion. No difference in staining intensity by grade of lesion was observed for Prx I, and IV. Therefore, we conclude that Prx II and III are upregulated in response to the development of cervical cancer.
Department of Biochemistry and Molecular biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyunghee University School of Medicine, Seoul 130-701, Korea.
Kiyoon
K
Kim
Miran
M
Yu
Seulhee
S
Han
Inkyung
I
Oh
Young-Jun
YJ
Choi
Sungsoo
S
Kim
Kyungsik
K
Yoon
Minhyung
M
Jung
Wonchae
W
Choe
D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D009367:Neoplasm Staging; D061105:Peroxiredoxin III; D054464:Peroxiredoxins / Q000032:analysis*; D046888:Tissue Array Analysis; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000201:enzymology* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000201:enzymology* / Q000473:pathology
D014408:Biomarkers, Tumor; D007527:Isoenzymes; C515940:PRDX1 protein, human; C086065:PRDX2 protein, human; C516115:PRDX3 protein, human; C515980:PRDX4 protein, human; D061105:Peroxiredoxin III; D054464:Peroxiredoxins