RecBCD and RecFOR dependent induction of chromosomal deletions by sodium selenite in Salmonella.
RecBCD and RecFOR homologous recombination pathways induced bacterial chromosomal duplication-segregation by sodium selenite (SSe) at sub-inhibitory concentrations. This evidence suggests that SSe induces both, double and single DNA strand damage with a concomitant DNA repair response, however the strong dependence for recombinogenic activity of RecB product suggests that the main DNA repair pathway copes with dsDNA breaks. A role for SSe recombinogenic induction is proposed to explain its effect on DNA instability.
Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico.
Javier
J
Espinosa-Aguirre
Claudia
C
Barajas-Lemus
Sandra
S
Hernández-Ojeda
Tzipe
T
Govezensky
Julieta
J
Rubio
Rafael
R
Camacho-Carranza
D001426:Bacterial Proteins / Q000378:metabolism; D002872:Chromosome Deletion; D002876:Chromosomes, Bacterial / Q000187:drug effects* / Q000235:genetics*; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism; D043211:Exodeoxyribonuclease V / Q000378:metabolism*; D005798:Genes, Bacterial; D011995:Recombination, Genetic; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D018038:Sodium Selenite / Q000633:toxicity*
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C065831:RecR protein, Bacteria; C066218:recF protein, Bacteria; D043211:Exodeoxyribonuclease V; D018038:Sodium Selenite