Hyperferritinemia is a risk factor for steatosis in chronic liver disease.
OBJECTIVE
To investigate the relationship between ferritin and steatosis in patients with chronically abnormal liver function tests (LFTs) and high ferritin level.


METHODS
One hundred and twenty-four consecutive patients with hyperferritinemia (male > 300 ng/mL, female > 200 ng/mL) were evaluated; clinical, biochemical and serological data, iron status parameters, HFE gene mutations and homeostasis model assessment score were obtained. Steatosis was graded by ultrasound as absent or present. Histology was available in 53 patients only.


RESULTS
Mean level of ferritin was 881 +/- 77 ng/mL in men and 549 +/- 82 ng/mL in women. The diagnosis was chronic hepatitis C in 53 (42.7%), non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in 57 (45.9%), and cryptogenic liver damage in 14 (11.3%). None was diagnosed as hereditary hemochromatosis (HH). Hepatic siderosis on liver biopsy was present in 17 of 54 (32%) patients; grade 1 in eight and grade 2 in nine. Overall, 92 patients (74.2%) had steatosis. By logistic regression, ferritin and gamma-glutamyltransferase were independent predictors of steatosis. Ferritin levels were significantly related to low platelet count, steatosis and hepatitis C virus infection.


CONCLUSIONS
In a non-obese cohort of non-alcoholic patients with chronically abnormal LFTs without HH, high serum ferritin level is a risk factor for steatosis.
Gastroenterology and Hepatology Unit, Department of Internal Medicine, University of Palermo, 90127 Palermo, Italy. annalisalicata@yahoo.com
Anna
A
Licata
Maria Elena
ME
Nebbia
Giuseppe
G
Cabibbo
Giovanna Lo
GL
Iacono
Francesco
F
Barbaria
Virna
V
Brucato
Nicola
N
Alessi
Salvatore
S
Porrovecchio
Vito
V
Di Marco
Antonio
A
Craxì
Calogero
C
Cammà
D002908:Chronic Disease; D005234:Fatty Liver / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000150:complications / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors
D005293:Ferritins