Severe combined immunodeficiency (SCID)-associated dyschromia with subsequent repigmentation: a report of two patients.
Severe combined immunodeficiency (SCID) often presents with mucosal infections, cutaneous infections and eczematous rashes. We present two patients with history of SCID diagnosed at an early age who experienced diffuse dyschromia associated with their bone marrow and stem cell transplants. Dyschromias may be caused by numerous factors including medications, genetics, environmental contacts, or as a sequela of underlying chronic disease. These case reports describe progressive repigmentation to original skin color after the occurrence of dyschromia in two patients with SCID.
Society Hill Dermatology, Philadelphia, Pennsylvania, USA.
Candrice R
CR
Heath
Cynthia J
CJ
Burk
Leslie P
LP
Lawley
Anthony J
AJ
Mancini
Elizabeth Alvarez
EA
Connelly
D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis; D006801:Humans; D008297:Male; D010859:Pigmentation Disorders / Q000175:diagnosis* / Q000209:etiology*; D016511:Severe Combined Immunodeficiency / Q000150:complications* / Q000628:therapy; D033581:Stem Cell Transplantation