A chemogenomic approach to drug discovery: focus on cardiovascular diseases.
References to individual protein targets and bioactive small molecules associated with cardiovascular diseases can be found in multiple bibliographic sources. From mining these sources, a highly curated list of 214 cardiovascular targets was collected and organised using functional classification schemes for the main protein families of therapeutic relevance, namely, enzymes, G-protein-coupled receptors, ion channels, and nuclear receptors. This list was then used to interrogate annotated chemical libraries and extract a chemical space of 44032 small molecules connected to 160 targets. Some of these bioactive ligands were also found to have affinity for an additional set of 421 proteins not linked originally to cardiovascular diseases, thus constituting a valuable indirect source to complete the cardiovascular target space and infer a potential off-cardiovascular target space.
Cases
Montserrat
M
Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Institut Municipal d'Investigació Mèdica and Universitat Pompeu Fabra, Parc de Recerca Biomèdica, Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain.
Mestres
Jordi
J
D002318:Cardiovascular Diseases / Q000378:metabolism*; D019992:Databases as Topic; D016503:Drug Delivery Systems; D055808:Drug Discovery / Q000379:methods*; D004798:Enzymes / Q000737:chemistry / Q000187:drug effects; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000187:drug effects; D008024:Ligands; D011485:Protein Binding; D040901:Proteomics / Q000379:methods*; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000187:drug effects; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000187:drug effects; D054852:Small Molecule Libraries
D004798:Enzymes; D007473:Ion Channels; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D043562:Receptors, G-Protein-Coupled; D054852:Small Molecule Libraries