Immediate provisionalization of NanoTite implants in support of single-tooth and unilateral restorations: one-year interim report of a prospective, multicenter study.
BACKGROUND
Clinical studies reporting immediate loading of endosseous implants for edentulous cases and for fixed partial restorations have been well documented with satisfactory survival rates. Implants with a recently developed, nanometer-scale surface topography (NanoTite, BIOMET 3i, Palm Beach Gardens, FL, USA), created by discrete crystalline depositions (DCD) of calcium phosphate nano-crystals onto a dual acid-etched (DAE) surface, show enhanced early fixation in preclinical studies when compared with DAE-surfaced implants. These outcomes suggest DCD-surfaced implants may be advantageous for immediate loading approaches.


OBJECTIVE
The aim of this prospective, multicenter, observational study is to report clinical outcomes for DCD-surfaced implants placed in immediate functional support of single- and multi-unit restorations according to an immediate loading protocol.


METHODS
One hundred eighty-five patients enrolled at 15 international study centers received a total of 335 implants supporting 216 immediate provisionalizations consisting of 128 single-tooth restorations and 88 fixed restorations. Of the 335 implants, 77% are located in posterior and 23% in anterior regions with 55.5% of the total in mandibles and 44.5% in maxillae. Patients were evaluated for implant mobility, gingival health, symptomatology, and radiographic outcomes.


RESULTS
At the time of this 1-year interim report, a total of 17 failures have been observed in 11 patients, yielding a cumulative survival rate of 94.9%.


CONCLUSIONS
Relative to other prospective, multicenter studies of immediately loaded implants with various surface enhancements, NanoTite implants perform comparatively well when immediately provisionalized with single-tooth and fixed restorations.
Department of Biomaterials, Institute for Surgical Sciences, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden. po@holmgatan.se
Pär-Olov
PO
Ostman
Markijan
M
Hupalo
Robert
R
del Castillo
Robert W
RW
Emery
Roberto
R
Cocchetto
Giampaolo
G
Vincenzi
Barry
B
Wagenberg
Bruno
B
Vanassche
Andreas
A
Valentin
Gerard
G
Clausen
Paul
P
Hogan
Ronnie
R
Goené
Christopher
C
Evans
Tiziano
T
Testori
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002130:Calcium Phosphates; D002484:Cementation; D003442:Crowns; D045662:Dental Etching; D003758:Dental Implantation, Endosseous; D019250:Dental Implants, Single-Tooth; D017267:Dental Prosthesis Design; D019232:Dental Restoration Failure; D003799:Dental Stress Analysis; D003831:Denture, Partial, Immediate; D003833:Denture, Partial, Temporary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053758:Nanoparticles; D011446:Prospective Studies; D013499:Surface Properties; D013997:Time Factors; D055815:Young Adult
D002130:Calcium Phosphates; C020243:calcium phosphate