Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein.
Nonobese children age 10.4 +/- 1.1 years diagnosed with dyslipidemia (n = 51) were compared to normal children age 10.8 +/- 1.1 years (n = 38). Affected individuals had increased total cholesterol: 223 +/- 23 vs 152 +/- 17 mg/dl, p < 0.001; and decreased high-density lipoprotein-cholesterol: 41.9 +/- 4.1 vs 57.6 +/- 5.7 mg/dl, p < 0.001 and triglycerides: 90.8 +/- 40.5 vs 65.7 +/- 25.0 mg/dl, p < 0.002. Fasting glucose was also significantly elevated (p < 0.02). All other parameters, including blood pressure, were not statistically different between groups. The concentration of C-reactive protein was not statistically different between groups. Analysis of medical records showed that this anomaly may be related to this group (as well as the control group) performing regular, daily exercise. This activity was quantified via a self administered questionnaire, and found to be statistically identical in controls and dyslipidemic individuals. Exercise is associated with the release of antiinflammatory cytokines, therefore our results support the contention that it is a significant factor in promoting health conditions from an early stage in life.
Vázquez
Miguel Arturo Salazar
MA
Facultad de Ciencias Químicas Gómez Palacio, Universidad Juárez del Estado de Durango, Dgo, México.
Vázquez
Beatriz Yadira Salazar
BY
Intaglietta
M
M
Cabrales
Pedro
P
D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides; D002097:C-Reactive Protein