Clinical spectrum of vulva metastatic Crohn's disease.
Crohn's disease is a chronic granulomatous disorder that may involve any segment of the gastrointestinal tract. Extraintestinal manifestations of Crohn's disease such as erythema nodosum and pyoderma gangrenosum are well recognized and appreciated. However, metastatic Crohn's disease (MCD), defined as the same granulomatous inflammation seen in Crohn's disease but at a skin site distant to the gastrointestinal tract, is less well recognized. We report three cases of MCD involving the perianal and vulvar skin that initially presented with vulvar pain.
Leu
Susan
S
Department of Medicine, Northwestern University Feinberg School of Medicine, 251 East Huron St., Galter Pavilion, Suite 3-150, Chicago, IL 60611, USA. susanleu@gmail.com
Sun
Patricia K
PK
Collyer
James
J
Smidt
Aimee
A
Stika
Catherine S
CS
Schlosser
Bethanee
B
Mirowski
Ginat W
GW
Vanagunas
Arvydas
A
Buchman
Alan L
AL
D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D001379:Azathioprine / Q000008:administration & dosage; D003106:Colon / Q000473:pathology; D003113:Colonoscopy; D003424:Crohn Disease / Q000175:diagnosis / Q000473:pathology*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D004487:Edema / Q000209:etiology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D000069285:Infliximab; D008875:Middle Aged; D010173:Palpation; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014845:Vulvar Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*
D000911:Antibodies, Monoclonal; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D001379:Azathioprine; D011241:Prednisone