Baculovirus interactions in vitro and in vivo.
Baculoviruses are promising viral insecticides and are safe for the environment. Interaction of baculoviruses in vitro and in vivo is a basic molecular and ecological question that has practical applications in agriculture. Cellular secretion is also a fundamental property in cell-cell communication. Here, we review recent investigations on how baculoviruses interact with insect cells and insect hosts. We focus particularly on a new interaction mechanism in which a secretion from cells infected with one virus enhances infection by a second virus. We also discuss a hypothesis that the secreted signals may serve as ligands that bind to the receptors on the surface of the cells that harbor the suppressed genomes of Thysanoplusia orichalcea MNPV (ThorMNPV) in Sf21 and Spodoptera exigua MNPV (SeMNPV) in High 5 to initiate signal transduction leading to the activation of genome replication of ThorMNPV in Sf21 and SeMNPV in High 5. We also discuss how the enhanced replication of SeMNPV replication by Autographa californica MNPV (AcMNPV) in nonpermissive insect cells depends on the types of cells. Interaction of baculoviruses in insects focused on mutualism and antagonism, even though the mechanism is not clear on mutualism. The antagonism of a Nucleopolyhedrovirus (NPV) with a Granulovirus (GV) has been extensively studied by a metalloprotein in the capsule of GV that disrupts the peritrophic membrane, a physical barrier to NPV entry to the midgut of larvae, to facilitate NPV infection.
Department of Microbiology, 32 Pearson Hall, Miami University, Oxford, Ohio 45056, USA.
Xiao-Wen
XW
Cheng
Dwight E
DE
Lynn
D000818:Animals; D016367:Baculoviridae / Q000472:pathogenicity* / Q000502:physiology*; D002478:Cells, Cultured; D054884:Host-Pathogen Interactions; D007814:Larva / Q000821:virology; D009036:Moths / Q000821:virology; D010572:Pest Control, Biological; D018411:Spodoptera / Q000821:virology; D014779:Virus Replication