Pituitary adenoma with craniopharyngioma component.
Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess. Here, we describe a pituitary adenoma with an intermingled craniopharyngioma component, without forming 2 distinct mass lesions or histologic delineation. Areas that suggest a transition between the 2 components were also present. It was clinically a nonfunctioning adenoma, which was also negative for pituitary hormones by immunohistochemistry. Its histogenesis and implications are discussed with a review of the literature.
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. mgokden@uams.edu
Murat
M
Gokden
Robert E
RE
Mrak
D000236:Adenoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D003397:Craniopharyngioma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D010911:Pituitary Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D051176:beta Catenin / Q000032:analysis
D014408:Biomarkers, Tumor; D051176:beta Catenin