Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico.
Mexico is developing the basis for genomic medicine to improve healthcare of its population. The extensive study of genetic diversity and linkage disequilibrium structure of different populations has made it possible to develop tagging and imputation strategies to comprehensively analyze common genetic variation in association studies of complex diseases. We assessed the benefit of a Mexican haplotype map to improve identification of genes related to common diseases in the Mexican population. We evaluated genetic diversity, linkage disequilibrium patterns, and extent of haplotype sharing using genomewide data from Mexican Mestizos from regions with different histories of admixture and particular population dynamics. Ancestry was evaluated by including 1 Mexican Amerindian group and data from the HapMap. Our results provide evidence of genetic differences between Mexican subpopulations that should be considered in the design and analysis of association studies of complex diseases. In addition, these results support the notion that a haplotype map of the Mexican Mestizo population can reduce the number of tag SNPs required to characterize common genetic variation in this population. This is one of the first genomewide genotyping efforts of a recently admixed population in Latin America.
National Institute of Genomic Medicine (INMEGEN), Periferico Sur No. 4124, Torre Zafiro II, 6to. Piso, Col. Jardines del Pedregal, Mexico D.F. 01900, Mexico.
Irma
I
Silva-Zolezzi
Alfredo
A
Hidalgo-Miranda
Jesus
J
Estrada-Gil
Juan Carlos
JC
Fernandez-Lopez
Laura
L
Uribe-Figueroa
Alejandra
A
Contreras
Eros
E
Balam-Ortiz
Laura
L
del Bosque-Plata
David
D
Velazquez-Fernandez
Cesar
C
Lara
Rodrigo
R
Goya
Enrique
E
Hernandez-Lemus
Carlos
C
Davila
Eduardo
E
Barrientos
Santiago
S
March
Gerardo
G
Jimenez-Sanchez
D000483:Alleles; D014644:Genetic Variation / Q000235:genetics*; D015894:Genome, Human / Q000235:genetics*; D023281:Genomics; D006239:Haplotypes; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008511:Medicine; D008800:Mexico