Synthesis and antimicrobial activity of 3-octyloxy-8-alkyljatrorrhizine derivatives.
By introducing octyloxy to C-3 and alkyl groups to C-8 of jatrorrhizine, a series of 3-octyloxy-8-alkyljatrorrhizine derivatives were synthesized and their antimicrobial activities were evaluated in vitro. The results indicated that the derivatives exhibited high antimicrobial activities, especially against Gram-positive bacteria. The 3-octyloxy-8-butyljatrorrhizine displayed the highest antimicrobial activity in all compounds. Their structure-activity relationships were discussed.
Wang
Li-Jun
LJ
Chemistry Institute of Pharmaceutical Resources, School of Pharmaceutical Science, Southwest University, Chongqing, China.
Ye
Xiao-Li
XL
Chen
Zhu
Z
Li
Xue-Gang
XG
Sun
Qing-Lei
QL
Zhang
Bao-Shun
BS
Cao
Xiao-Gang
XG
Yu
Gang
G
Niu
Xiao-Hua
XH
D001419:Bacteria / Q000187:drug effects*; D001599:Berberine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D041022:Candida tropicalis / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D029626:Ranunculaceae / Q000737:chemistry
C540986:3-octyloxy-8-ethyljatrorrhizine; D004365:Drugs, Chinese Herbal; C055785:jatrorrhizine; D001599:Berberine