Activities of naphthoquinones against Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae), vector of dengue and Biomphalaria glabrata (Say, 1818), intermediate host of Schistosoma mansoni.
Larvicidal (against Aedes aegypti Linnaeus, 1762) and molluscicidal (against Biomphalaria glabrata Say, 1818) activities of several natural and synthetic naphthoquinones were measured, with significant results. The best larvicidal compound is 3-bromojuglone, while the better molluscicides are 2-bromo- and 3-bromo-5-acetoxy-1,4-naphthoquinones together with the 3-bromo-5-methoxy derivative. The present results reinforce the potential use of substituted hydroxyquinones, their salts and halogenated quinones as very promising compounds against 4th instar larves of Aedes aegypti, the vector of dengue and against adult snail of Biomphalaria glabrata.
Ribeiro
Karlos A L
KA
Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Alagoas, Brazil.
de Carvalho
Cenira Monteiro
CM
Molina
Maria Teresa
MT
Lima
Estelita Pereira
EP
López-Montero
Eulogio
E
Reys
José Rui M
JR
de Oliveira
Maria Beatriz Farias
MB
Pinto
Antonio Ventura
AV
Santana
Antônio Euzébio G
AE
Goulart
Marília O F
MO
D000330:Aedes / Q000187:drug effects*; D000818:Animals; D000977:Antiparasitic Agents / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001700:Biomphalaria / Q000187:drug effects*; D007306:Insecticides / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*
D000977:Antiparasitic Agents; D007306:Insecticides; D009285:Naphthoquinones