Long-lived ames dwarf mice are resistant to chemical stressors.
To probe the connection between longevity and stress resistance, we compared the sensitivity of Ames long-lived dwarf mice and control littermates with paraquat, diquat, and dobutamine. In young adult animals, 95% of male and 39% of female controls died after paraquat administration, but no dwarf animals died. When the experiment was repeated at an older age or a higher dosage of paraquat, dwarf mice still showed greater resistance. Dwarf mice also were more resistant to diquat; 80% of male and 60% of female controls died compared with 40% and 20% of dwarf mice, despite greater sensitivity of dwarf liver to diquat. Dwarf mice were also less sensitive to dobutamine-induced cardiac stress and had lower levels of liver and lung F(2)-isoprostanes. This is the first direct in vivo evidence that long-lived Ames dwarf mice have enhanced resistance to chemical insult, particularly oxidative stressors.
Sam and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, Texas Research Park Campus, 15355 Lambda Drive-MSC 7755, San Antonio, TX 78245-3207, USA.
Alex F
AF
Bokov
Merry L
ML
Lindsey
Christina
C
Khodr
Marian R
MR
Sabia
Arlan
A
Richardson
D000375:Aging / Q000378:metabolism; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D004178:Diquat / Q000633:toxicity*; D004392:Dwarfism / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects; D008136:Longevity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress; D010269:Paraquat / Q000633:toxicity*
D004178:Diquat; D000410:Alanine Transaminase; D010269:Paraquat