Inhibitions of urinary oxidative stress and renal calcium level by  an extract of Quercus salicina Blume/Quercus stenophylla Makino  in a rat calcium oxalate urolithiasis model.
OBJECTIVE
To clarify the mechanism of Urocalun, an extract of Quercus salicina Blume/Quercus stenophylla Makino (QS), in the treatment of urolithiasis.


METHODS
Rat calcium oxalate urolithiasis was induced by oral administration of ethylene glycol and the vitamin D3 analog alfa-calcidol for 14 days. QS extract was repeatedly given to rats. After the last administration, biochemistries in urine and plasma, renal calcium, and urinary malondialdehyde (an oxidative stress marker) were measured.


RESULTS
Ethylene glycol and alfa-calcidol treatment increased urinary malondialdehyde and renal calcium levels. This increase was significantly suppressed by the administration of QS extract, suggesting that the inhibition of renal calcium accumulation by QS extract is due to its antioxidative activity.


CONCLUSIONS
These findings suggest that the antioxidative activity of QS extract plays a role in the prevention of stone formation and recurrence in urolithiasis.
Department of Urogenital Surgery, Kanazawa Medical University, Kahoku, Ishikawa, Japan. moriyama@kanazawa-med.ac.jp
Manabu T
MT
Moriyama
Koudai
K
Suga
Katsuhito
K
Miyazawa
Tatsuro
T
Tanaka
Masaya
M
Higashioka
Kumiko
K
Noda
Michiko
M
Oka
Mitsushi
M
Tanaka
Koji
K
Suzuki
D000818:Animals; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D002129:Calcium Oxalate / Q000378:metabolism; D004195:Disease Models, Animal; D007668:Kidney / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D029963:Quercus; D051381:Rats; D017207:Rats, Sprague-Dawley; D052878:Urolithiasis / Q000378:metabolism / Q000517:prevention & control*
D010936:Plant Extracts; D002129:Calcium Oxalate; D002118:Calcium