The beta3-adrenoceptor as a therapeutic target: current perspectives.
beta(3)-Adrenoceptors (beta(3)-ARs) are located not only on the plasma membrane of both white and brown adipocytes, but also exist in human heart, gall bladder, gastrointestinal tract, prostate, urinary bladder detrusor, brain and in near-term myometrium. They are now recognized as an attractive target for drug discovery and several efforts have been made in this field to understand their function and regulation in different human tissues. The aim of this review is to highlight the functional role of beta(3)-ARs as well as to discuss their potential for drug development.
Ursino
Maria Grazia
MG
Department of Pharmacology, University of Bologna, Via Irnerio, 48, I-40126 Bologna, Italy.
Vasina
Valentina
V
Raschi
Emanuel
E
Crema
Francesca
F
De Ponti
Fabrizio
F
D000322:Adrenergic Agonists / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D018674:Adrenergic Antagonists / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D058667:Adrenergic beta-3 Receptor Agonists; D058673:Adrenergic beta-3 Receptor Antagonists; D000818:Animals; D016503:Drug Delivery Systems; D055808:Drug Discovery; D006801:Humans; D008954:Models, Biological; D022702:Receptors, Adrenergic, beta-3 / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction; D014018:Tissue Distribution
D000322:Adrenergic Agonists; D018674:Adrenergic Antagonists; D058667:Adrenergic beta-3 Receptor Agonists; D058673:Adrenergic beta-3 Receptor Antagonists; D022702:Receptors, Adrenergic, beta-3