Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons.
Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.
Lin
Yi-Chien
YC
Graduate Institute of Pharmaceutic Chemistry, China Medical University, Taichung 404, Taiwan.
Chou
Li-Chen
LC
Chen
Sheng-Chih
SC
Kuo
Sheng-Chu
SC
Huang
Li-Jiau
LJ
Gean
Po-Wu
PW
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002478:Cells, Cultured; D002540:Cerebral Cortex; D004791:Enzyme Inhibitors; D006801:Humans; D007191:Indazoles / Q000737:chemistry / Q000494:pharmacology*; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D007191:Indazoles; C064769:N-acetylsphingosine; D018696:Neuroprotective Agents; D011720:Pyrazoles; D013110:Sphingosine