Preparation of size tunable amphiphilic poly(amino acid) nanoparticles.
Size tunable amphiphilic NPs composed of poly(gamma-PGA) and hydrophobic amino acids, such as Phe or Trp, were prepared. To prepare these size-regulated NPs, gamma-PGA-g-Phe or gamma-PGA-g-Trp dissolved in DMSO was added to various concentrations of NaCl solution. The gamma-PGA-Phe and gamma-PGA-Trp formed monodispersed NPs, and the size of NPs can be easily controlled by NaCl concentration. The different-sized NPs showed the same structure. The encapsulation of protein into the different-sized NPs was successfully achieved and the size of protein-encapsulated gamma-PGA-Phe NPs was increased when protein was encapsulated.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan.
Hyungjin
H
Kim
Takami
T
Akagi
Mitsuru
M
Akashi
D001672:Biocompatible Materials / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010047:Ovalbumin / Q000737:chemistry / Q000378:metabolism; D010316:Particle Size; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry
D001672:Biocompatible Materials; D004337:Drug Carriers; C511775:poly(gamma-glutamic acid); D011099:Polyglutamic Acid; D010047:Ovalbumin