Downbeat nystagmus caused by a paramedian ponto-medullary lesion.
Downbeat nystagmus (DBN) is rarely caused by lesions in sites other than the cerebellar (para-)floccular lobe. We describe a case of DBN secondary to a hemorrhaged venous cavernoma at the pontomedullary junction. This case provides new insights into the neuro-anatomical substrate of DBN. We propose that DBN arises from lesions in a brainstem-cerebellar feedback loop, which comprises cells of the pontine paramedian tract (PMT).
Judith
J
Wagner
Nadine
N
Lehnen
Stefan
S
Glasauer
Nicole
N
Rettinger
Ulrich
U
Büttner
Thomas
T
Brandt
Michael
M
Strupp
D001933:Brain Stem / Q000473:pathology*; D020785:Central Nervous System Vascular Malformations / Q000150:complications / Q000473:pathology; D053483:Eye Movement Measurements; D005133:Eye Movements; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000209:etiology* / Q000473:pathology*