Surveillance of vaccine safety: comparison of parental reports with routine surveillance and a clinical trial.
One way to maintain confidence in vaccination programmes is to improve monitoring of immunisation safety. We studied active parental reporting of adverse events after a booster dose of diphtheria-tetanus toxoid (DT). 7193 children received the vaccine. Questionnaires were submitted by 84.2% of the parents, who reported reactions for 9.2% of the children. Four percent of events were classified as moderate/severe by interviews. Relative risk of redness and swelling reported was 0.24 (95% CI, 0.13-0.42) compared to a clinical trial, while it was 71.0 (44-114) compared to passive surveillance. Active surveillance by parental reports is a useful complement to passive surveillance of childhood immunisations to generate hypotheses for evaluation in controlled studies.
Lund University, Department of Clinical Sciences, Malmö, Sweden. Eva.Netterlid@med.lu.se
Eva
E
Netterlid
Marie Edwinson
ME
Månsson
Anders
A
Håkansson
D002648:Child; D002986:Clinical Trials as Topic; D022422:Diphtheria-Tetanus Vaccine / Q000008:administration & dosage* / Q000009:adverse effects*; D004487:Edema / Q000209:etiology; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects*; D007267:Injections; D007407:Interviews as Topic; D012449:Safety; D018571:Sentinel Surveillance; D011795:Surveys and Questionnaires; D013548:Sweden
D022422:Diphtheria-Tetanus Vaccine