Enantioselective synthesis of chiral alpha-aryl or alpha-alkyl substituted ethylphosphonates via Rh-catalyzed asymmetric hydrogenation with a P-stereogenic BoPhoz-type ligand.
An enantioselective synthesis of optically active 1-aryl or 1-alkyl substituted ethylphosphonates, based on the first Rh-catalyzed asymmetric hydrogenation of corresponding alpha,beta-unsaturated precursors with a P-stereogenic BoPhoz-type ligand under the mild condition, was developed, in which a wide range of 1-aryl or 1-alkyl substituted ethylphosphonates were achieved in up to 98% ee.
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Dao-Yong
DY
Wang
Xiang-Ping
XP
Hu
Jun
J
Deng
Sai-Bo
SB
Yu
Zheng-Chao
ZC
Duan
Zhuo
Z
Zheng
D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D063065:Organophosphonates / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D012238:Rhodium; D013237:Stereoisomerism
D008024:Ligands; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D012238:Rhodium