[Experimental study on osteoinduction active material in repairing the peri-implant bone defect].
OBJECTIVE
To explore the potential of using osteoinduction active material (OAM) for reconstruction of bone defects of peri-implant by animal experiment, and provide experimental evidence for clinical application.


METHODS
Four Beagle dogs underwent extraction of the mandibular first and second premolar to create edentulous regions. 2 groups were divided randomly. Three months later, titanium implants were inserted and peri-implant bone defect models were established. The bone defects were repaired with OAM in the experimental group and repaired with tricalcium phosphate (TCP) in the control group. Two animals each were sacrificed at the end of 8 weeks and 16 weeks respectively. The specimens were evaluated with histological examination, scanning electric microscope, bone density examination, and energy disperse analysis of Ca(2+). The data was analyzed with SPSS13.0 software package for Student's t test.


RESULTS
At 8-week,some parts of implants in the experimental group were directly contacted with new bone. There were fibers between the bone and implant in the control group. There was no significant difference between the experimental group and the control group in bone density (P>0.05). The percentage of Ca(2+) of the experimental group(22.16+/-3.33) was significantly greater than that of the control group(3.13+/-2.44) (P<0.05). At 16-week, there was good osseointegration between the bone and implant in the experimental group but no new bone formation in the control group. The bone density of the experimental group was significantly greater than that of the control group (P<0.05). The percentage of Ca(2+) of the experimental group(42.23+/-6.20) was significantly greater than that of the control group(10.40+/-3.12)(P<0.05).


CONCLUSIONS
The results suggest that OAM can effectively accelerate the reconstruction of peri-implant bone defects and improve the osseointegration in the interface between the implant and bone.
Zhao
Wang
W
Department of Stomatology, the Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. happyzhao4@sina.com
Wang
Qiu-Xu
QX
Liu
Wei-Xian
WX
D000818:Animals; D001641:Bicuspid; D015519:Bone Density; D002130:Calcium Phosphates; D015921:Dental Implants; D004285:Dogs; D008334:Mandible; D016348:Osseointegration; D014025:Titanium; D014945:Wound Healing
D002130:Calcium Phosphates; D015921:Dental Implants; D014025:Titanium; C018392:tricalcium phosphate