Recent advances in enantioselective copper-catalyzed 1,4-addition.
A comprehensive overview of recent literature from 2003 concerning advances in enantioselective copper catalysed 1,4-addition of organometallic reagents to alpha,beta-unsaturated compounds is given in this critical review. About 200 ligands and catalysts are presented, with a focus on stereoselectivities, catalyst loading, ligand structure and substrate scope. A major part is devoted to trapping and tandem reactions and a variety of recent synthetic applications are used to illustrate the practicality and current state of the art of 1,4-addition of organometallic reagents. Finally several mechanistic studies are discussed (162 references).
Jerphagnon
Thomas
T
University of Groningen, Stratingh Institute for Chemistry, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Pizzuti
M Gabriella
MG
Minnaard
Adriaan J
AJ
Feringa
Ben L
BL