[Effect of proteinase inhibitors on efficiency of suppression of proteolytic activation in pneumonia].
We studied the influence of a way of introduction proteinase inhibitors on efficiency of suppression of proteolysis activation during pneumonia. Comparative study of efficiency of proteases inhibition in experimental pneumonia has shown higher efficacy of local introduction of drugs. Intravenous and intraperitoneal introduction of proteinase inhibitors exhibited inhibitory effect of a smaller degree on local and systemic proteases activation, did not decrease an acute phase of response of alpha-1-protease inhibitor in comparison with endotracheal instillation of Contrycal and Ingiprol. The study has established that endotracheal introduction of proteinase inhibitors is the most effective for correction of the proteinase-inhibitor balance. It also helps to promote the activity proteinase-inhibitor, suppresses elastolytic activity, decreases cellular infiltration, reduces the concentration of proteins in bronco-alveolar lavage fluid that is connected with address delivery of drugs to the target organ creating a maximal concentration of drugs in affected area.
A V
AV
Kubyshkin
I I
II
Fomochkina
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007322:Instillation, Drug; D007442:Intubation, Intratracheal; D010447:Peptide Hydrolases / Q000378:metabolism*; D011014:Pneumonia / Q000188:drug therapy* / Q000201:enzymology*; D011480:Protease Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D011480:Protease Inhibitors; D010447:Peptide Hydrolases