Influence of gender and menopausal status on antidepressant treatment response in depressed inpatients.
The present study investigated the influence of gender and menopausal status on treatment response in depressed inpatients, treated with either imipramine or fluvoxamine. The patients were divided into three groups: men, premenopausal women and postmenopausal women. A multivariate analysis was performed using the difference in Hamilton score (pretreatment - post-treatment) for imipramine and fluvoxamine as dependent variable. The following independent variables were used: the baseline Hamilton score, the antidepressant used, the gender-group and the interaction between the type of antidepressant and gender. In total, 138 patients with a DSM IV diagnosis of depressive disorder were analysed. Men responded more favorably to imipramine (B = 7.12, P = 0.005). Premenopausal women had a better response rate to fluvoxamine than men (B = -8.66, P = 0.027). In depressed inpatients, men respond more favorably to imipramine than to fluvoxamine. Premenopausal women respond more frequently to fluvoxamine than men.
Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands.
M
M
Vermeiden
W W
WW
van den Broek
P G H
PG
Mulder
T K
TK
Birkenhäger
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D016666:Fluvoxamine / Q000627:therapeutic use*; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D007297:Inpatients; D016014:Linear Models; D008297:Male; D008593:Menopause / Q000523:psychology*; D008875:Middle Aged; D009426:Netherlands; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult
D000928:Antidepressive Agents; D016666:Fluvoxamine; D007099:Imipramine