Prenylflavonols from the leaves of Macaranga sampsonii.
Four novel prenylflavonols, macaranones A-D (1-4), were isolated from the leaves of Macaranga sampsonii. Their structures were elucidated on the basis of spectroscopic data. Macaranones C (3) and D (4) represent first two examples of flavonols having an unusual peltogynoid skeleton which is formed from a 2'-geranylflavonol by cyclization between 3-OH and C-1'' of the 2'-geranyl substituent of the flavonol. Compounds 1-4 were evaluated for the cytotoxicity against several human cancer cell lines.
Li
Xiaohua
X
Key Labotatory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.
Xu
Liangxiong
L
Wu
Ping
P
Xie
Haihui
H
Huang
Zhongliang
Z
Ye
Wanhui
W
Wei
Xiaoyi
X
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D019665:Euphorbiaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000633:toxicity; D044948:Flavonols / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry*; D054876:Prenylation
D000970:Antineoplastic Agents; D005419:Flavonoids; D044948:Flavonols; D010936:Plant Extracts; C540604:macaranone A; C540606:macaranone B; C540605:macaranone C; C540607:macaranone D