Preparation and physicochemical characterization of surfactant based solid dispersions of ezetimibe.
Solid dispersions of the poorly water-soluble drug ezetimibe were prepared with a surfactant, Pluronic 188 in different ratios and characterized by FTIR, XRD, DSC and dissolution studies. The melting method was employed to prepare the solid dispersions whereas a physical mixture (1:3) was prepared by co-grinding the individual components in a mortar. Physical studies demonstrated a significant reduction in crystallinity with a possibility of presence of amorphous character of drug in the solid dispersions of ezetimibe. Among all binary systems studied, the 1:3 proportion of ezetimibe: Pluronic 188 showed fastest dissolution rate (DE90: 73.38% +/- 3.95) suggesting optimum ratio of the surfactant used.
Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra, India.
P P
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Sancheti
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Karekar
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Vyas
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Shah
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Pore
D000924:Anticholesteremic Agents / Q000737:chemistry*; D001384:Azetidines / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D000069438:Ezetimibe; D007700:Kinetics; D020442:Poloxamer / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry; D014961:X-Ray Diffraction
D000924:Anticholesteremic Agents; D001384:Azetidines; D013501:Surface-Active Agents; D020442:Poloxamer; D000069438:Ezetimibe