Long-lived ames dwarf mice are resistant to chemical stressors.
To probe the connection between longevity and stress resistance, we compared the sensitivity of Ames long-lived dwarf mice and control littermates with paraquat, diquat, and dobutamine. In young adult animals, 95% of male and 39% of female controls died after paraquat administration, but no dwarf animals died. When the experiment was repeated at an older age or a higher dosage of paraquat, dwarf mice still showed greater resistance. Dwarf mice also were more resistant to diquat; 80% of male and 60% of female controls died compared with 40% and 20% of dwarf mice, despite greater sensitivity of dwarf liver to diquat. Dwarf mice were also less sensitive to dobutamine-induced cardiac stress and had lower levels of liver and lung F(2)-isoprostanes. This is the first direct in vivo evidence that long-lived Ames dwarf mice have enhanced resistance to chemical insult, particularly oxidative stressors.
Bokov
Alex F
AF
Sam and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, Texas Research Park Campus, 15355 Lambda Drive-MSC 7755, San Antonio, TX 78245-3207, USA.
Lindsey
Merry L
ML
Khodr
Christina
C
Sabia
Marian R
MR
Richardson
Arlan
A
D000375:Aging / Q000378:metabolism; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D004178:Diquat / Q000633:toxicity*; D004392:Dwarfism / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects; D008136:Longevity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress; D010269:Paraquat / Q000633:toxicity*
D004178:Diquat; D000410:Alanine Transaminase; D010269:Paraquat