Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}.
Micellar mannose nanoparticles were constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]} with fluorophores or quenchers doped into the hydrophobic inner cores, allowing the direct monitoring of multivalent lectin-glycan interactions. The mannose-displaying nanoparticles bind Con A and sperm surface lectins with high affinity, suggesting their broad utility for modulating protein-carbohydrate interaction mediated cell surface biology.
Su
Rongmin
R
Department of Chemistry, College of Chemistry and Chemical Engineering, and The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, 361005, P. R. China.
Li
Lei
L
Chen
Xiaoping
X
Han
Jiahuai
J
Han
Shoufa
S
D003460:Crystallization; D005459:Fluorides / Q000737:chemistry; D006801:Humans; D008297:Male; D008299:Maleic Anhydrides / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry*; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry; D013094:Spermatozoa / Q000737:chemistry; D020058:Styrene / Q000737:chemistry*
D008299:Maleic Anhydrides; D008823:Micelles; D010710:Phosphates; C012980:fluorophosphate; D020058:Styrene; D008358:Mannose; D005459:Fluorides