Bioinspired colorimetric detection of calcium(II) ions in serum using calsequestrin-functionalized gold nanoparticles.
Seeing is sensing: Calsequestrin (CSQ) functionalized gold nanoparticles undergo calcium-dependent CSQ polymerization, which results in a clear color change (see picture) together with precipitation. The sensing system is specific for Ca(2+) ions and the differences between normal and disease-associated abnormal (hypercalcemia) Ca(2+) ion levels in serum can be distinguished with the naked eye.
Kim
Sunghyun
S
Cell Dynamics Research Center, Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong-dong, Gwangju 500-712, South Korea.
Park
Jeong Won
JW
Kim
Dongkyu
D
Kim
Daejin
D
Lee
In-Hyun
IH
Jon
Sangyong
S
D015374:Biosensing Techniques; D002118:Calcium / Q000097:blood* / Q000737:chemistry; D002155:Calsequestrin / Q000737:chemistry*; D002413:Cations, Divalent / Q000097:blood*; D003124:Colorimetry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*
D002155:Calsequestrin; D002413:Cations, Divalent; D006046:Gold; D002118:Calcium