Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.
Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 microM and a therapeutic index (TI) of more than 25.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
Xiao-Nian
XN
Li
Jian-Xin
JX
Pu
Xue
X
Du
Liu-Meng
LM
Yang
Hui-Mei
HM
An
Chun
C
Lei
Fei
F
He
Xiao
X
Luo
Yong-Tang
YT
Zheng
Yang
Y
Lu
Wei-Lie
WL
Xiao
Han-Dong
HD
Sun
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D032141:Schisandra / Q000737:chemistry*; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D017705:Lignans; C542030:tiegusanin G