The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition.
Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products.
Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK. francesca.crowe@ceu.ox.ac.uk
Francesca L
FL
Crowe
Timothy J
TJ
Key
Naomi E
NE
Allen
Paul N
PN
Appleby
Andrew
A
Roddam
Kim
K
Overvad
Henning
H
Grønbaek
Anne
A
Tjønneland
Jutte
J
Halkjaer
Laure
L
Dossus
Heiner
H
Boeing
Janine
J
Kröger
Antonia
A
Trichopoulou
Vardis
V
Dilis
Dimitrios
D
Trichopoulos
Marie-Christine
MC
Boutron-Ruault
Blandine
B
De Lauzon
Françoise
F
Clavel-Chapelon
Domenico
D
Palli
Franco
F
Berrino
Salvatore
S
Panico
Rosario
R
Tumino
Carlotta
C
Sacerdote
H Bas
HB
Bueno-de-Mesquita
Alina
A
Vrieling
Carla H
CH
van Gils
Petra H M
PH
Peeters
Inger T
IT
Gram
Guri
G
Skeie
Eiliv
E
Lund
Laudina
L
Rodríguez
Paula
P
Jakszyn
Esther
E
Molina-Montes
María J
MJ
Tormo
Aurelio
A
Barricarte
Nerea
N
Larrañaga
Kay-Tee
KT
Khaw
Sheila
S
Bingham
Sabina
S
Rinaldi
Nadia
N
Slimani
Teresa
T
Norat
Valentina
V
Gallo
Elio
E
Riboli
Rudolf
R
Kaaks
D000367:Age Factors; D015992:Body Mass Index; D002136:Calcium, Dietary / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D004032:Diet; D002149:Energy Intake; D005060:Europe; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011506:Proteins / Q000008:administration & dosage; D012737:Sex Factors; D011795:Surveys and Questionnaires
D002136:Calcium, Dietary; D018970:Insulin-Like Growth Factor Binding Protein 1; D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D011506:Proteins; D007334:Insulin-Like Growth Factor I