T-cell assay as a diagnostic tool for tuberculosis.
This study aimed to estimate the specificity and sensitivity of a whole blood IFNg assay (ELISPOT) test for diagnosis in childhood tuberculosis. 96 patients, less than 18 years of age, diagnosed and commenced on antitubercular therapy were enrolled and tested. 47 age and sex matched controls were also tested. 23 tests were deemed invalid and analysis done on the remainder. The sensitivity was 53.3% in confirmed cases and less in other groups. The specificity was high at 97.9% This test can be an useful aid in the diagnosis of tuberculosis.
Warier
A
A
Department of Child Health, Low Cost Effective Care Unit and Department of Community Health, Christian Medical College, Vellore, India.
Gunawathi
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S
Venkatesh
John
K R
KR
Bose
A
A
D000293:Adolescent; D000942:Antigens, Bacterial / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D007371:Interferon-gamma / Q000378:metabolism*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D014376:Tuberculosis / Q000175:diagnosis / Q000276:immunology*
D000942:Antigens, Bacterial; D007371:Interferon-gamma