A comparison of prediction equations for estimating glomerular filtration rate in pregnancy.
OBJECTIVE
To compare existing glomerular filtration rate (GFR) prediction equations with the gold standard, inulin clearance, in pregnancy.


METHODS
Five equations were assessed for precision, bias, and accuracy in prediction of true GFR, measured by inulin clearance in 12 healthy, pregnant women during the second (T2) and third (T3) trimesters and in postpartum (PP).


RESULTS
Precision was greatest with 24-hour creatinine clearance estimation of GFR (R(2) = 13% (T2), R(2) = 26% (T3)). Other than 100/SCr, all equations underestimated true GFR. 30% accuracy was greatest in 100/SCr (83% (T2), 92% (T3)).


CONCLUSIONS
Current GFR prediction formulae do not appear to be sufficient for estimating GFR in the gravid state.
Division of Nephrology, Department of Medicine, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada. sofia.ahmed@calgaryhealthregion.ca
Sofia B
SB
Ahmed
Rhonda
R
Bentley-Lewis
Norman K
NK
Hollenberg
Steven W
SW
Graves
Ellen W
EW
Seely
D000328:Adult; D000465:Algorithms; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007444:Inulin; D007668:Kidney / Q000502:physiology*; D008954:Models, Biological; D011247:Pregnancy
D007444:Inulin