Plasmonically controlled nucleic acid dehybridization with gold nanoprisms.
Remote release: Triangular gold nanoprisms convert 1064 nm laser irradiation into heat selectively to allow the dehybridization of oligonucleotide conjugated to their surface (see scheme). These conjugates show unprecedented morphological stability under hours of irradiation. Released nucleic acids are unharmed by this process and can be repeatedly dehybridized and sequestered under spatiotemporal control.
Department of Chemistry, International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
Matthew R
MR
Jones
Jill E
JE
Millstone
David A
DA
Giljohann
Dwight S
DS
Seferos
Kaylie L
KL
Young
Chad A
CA
Mirkin
D006046:Gold / Q000737:chemistry*; D007834:Lasers; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry*; D020349:Surface Plasmon Resonance
D009841:Oligonucleotides; D006046:Gold