Leukocyte phenotyping to stratify septic shock patients.
In a recent study conducted in a cohort of 52 septic patients, Monserrat and coworkers found that profound failure of peripheral T cells to convert from a naïve phenotype to an activated phenotype has positive predictive value in identifying patients who do not recover. These data support the hypothesis that failure of the innate immune system to engage the T-cell compartment contributes to sepsis mortality and provides motivation for the development and clinical evaluation of immunostimulatory therapies for patients with sepsis.
McDunn
Jonathan E
JE
Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MI 63110, USA.
Hotchkiss
Richard S
RS
D035843:Biomedical Research; D015331:Cohort Studies; D016638:Critical Illness / Q000401:mortality; D006801:Humans; D016130:Immunophenotyping; D007362:Intensive Care Units; D018805:Sepsis / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*