Signaling pathways regulating zebrafish lateral line development.
The lateral line organ is a mechanosensory organ of fish and amphibians that detects changes in water flow. The lateral line organ of zebrafish has been used as a model for cell polarity and collective cell migration as well as hair cell loss and regeneration. A combination of genetic tools and live imaging has allowed dissection of signaling pathways that regulate these processes. Here, we summarize recent findings on the roles of the FGF, Wnt/beta-catenin, and Notch pathways in the initial formation of the posterior lateral line primordium, as well as during organ patterning, migration, cell fate specification and hair cell regeneration.
University of Washington, Box 357420, Seattle, WA 98195-7420, USA.
Eva Y
EY
Ma
David W
DW
Raible
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D005346:Fibroblast Growth Factors / Q000378:metabolism; D053403:Lateral Line System / Q000196:embryology* / Q000378:metabolism*; D009024:Morphogenesis / Q000502:physiology*; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology*; D051176:beta Catenin / Q000378:metabolism
D051880:Receptors, Notch; D051153:Wnt Proteins; D051176:beta Catenin; D005346:Fibroblast Growth Factors