Fluorescent organic nanoparticle formation in lysosomes for cancer cell recognition.
We present a convenient method to prepare fluorophores 3- or 3,7-divinyl substituted 10H-phenothiazines and their protonation forms can aggregate to become fluorescent organic nanoparticles (FONs) with bright fluorescent spots in the lysosomes of cancer cells but not normal cells.
Department of Chemistry, National Chung Hsing University, 250, Kuo Kuang Road, Taichung, 402, Taiwan, R.O.C.
Hsin-Hung
HH
Lin
Sheng-Yuan
SY
Su
Cheng-Chung
CC
Chang
D000818:Animals; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000737:chemistry / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology*; D010640:Phenothiazines / Q000138:chemical synthesis*; D011522:Protons
D005456:Fluorescent Dyes; D010640:Phenothiazines; D011522:Protons