Mu2-alkyne dicobalt(0)hexacarbonyl complexes as carbon monoxide-releasing molecules (CO-RMs): probing the release mechanism.
The first carbon monoxide-releasing molecules (CO-RMs) based on mu2-alkyne dicobalt(0)hexacarbonyl complexes are reported. The alkyne substituents significantly affect the rate of CO-release, cytotoxicity and cell viability. Mechanistic studies provide insight into the CO-RM activation pathways.
Department of Chemistry, University of York, Heslington, York, UK YO10 5DD.
Anthony J
AJ
Atkin
Sophie
S
Williams
Philip
P
Sawle
Roberto
R
Motterlini
Jason M
JM
Lynam
Ian J S
IJ
Fairlamb
D000480:Alkynes / Q000737:chemistry*; D000818:Animals; D002248:Carbon Monoxide / Q000737:chemistry / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D009942:Organometallic Compounds / Q000737:chemistry* / Q000633:toxicity; D013696:Temperature; D013997:Time Factors
D000480:Alkynes; D004337:Drug Carriers; D009942:Organometallic Compounds; D003035:Cobalt; D002248:Carbon Monoxide