Chiral 1,1'-binaphthylazepine-derived amino alcohol catalyzed asymmetric aryl transfer reactions with boroxine as aryl source.
Using chiral 1,1'-binaphthylazepine-derived amino alcohol as catalyst, the direct addition of in situ prepared arylzinc (with triphenylboroxine as aryl source) to various aryl aldehydes can afford optically active diarylmethanols in high yields and enantioselectivities (up to 96%).
Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.
Can
C
Liu
Zong-Liang
ZL
Guo
Jiang
J
Weng
Gui
G
Lu
Albert S C
AS
Chan
D000605:Amino Alcohols / Q000737:chemistry*; D001381:Azepines / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
C546924:1,1'-binaphthylazepine; D000605:Amino Alcohols; D001381:Azepines; D001896:Boron Compounds; D009281:Naphthalenes