Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes.
Chromatin-modifying factors have essential roles in DNA processing pathways that dictate cellular functions. The ability of chromatin modifiers, including the INO80 and SWR1 chromatin-remodelling complexes, to regulate transcriptional processes is well established. However, recent studies reveal that the INO80 and SWR1 complexes have crucial functions in many other essential processes, including DNA repair, checkpoint regulation, DNA replication, telomere maintenance and chromosome segregation. During these diverse nuclear processes, the INO80 and SWR1 complexes function cooperatively with their histone substrates, gamma-H2AX and H2AZ. This research reveals that INO80 and SWR1 ATP-dependent chromatin remodelling is an integral component of pathways that maintain genomic integrity.
University of Texas M. D. Anderson Cancer Center, Science Park Research Division, Department of Carcinogenesis, Smithville, Texas 78957, USA. ashbym@stanford.edu
Ashby J
AJ
Morrison
Xuetong
X
Shen
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D002843:Chromatin / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D015825:Chromosomes, Fungal / Q000378:metabolism / Q000648:ultrastructure; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D004261:DNA Replication; D006657:Histones / Q000145:classification / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D010802:Phylogeny; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D016415:Sequence Alignment; D014158:Transcription, Genetic
D002843:Chromatin; D006657:Histones; C483404:INO80 complex, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D000251:Adenosine Triphosphatases; C481261:Swr1 protein, S cerevisiae