[Disseminated cutaneous granulomatosis].
The disseminated cutaneous granulomatosis (DCG) are heterogeneous cutaneous diseases histologically characterized by a granulomatous infiltrate. The most frequent cutaneous granulomatosis is sarcoidosis, but many other causes can be found, because DCG are probably a skin granulomatous reaction to different stimuli: infectious, inflammatory, neoplastic, metabolic or chemical. The histopathological examination is useful for the diagnosis of DCG, but gives rarely an etiological diagnosis. In this article, we will propose a strategy for the etiological diagnosis of DCG, and propose therapeutic recommendations based on recent data from the literature.
Service de dermatologie, et vénéréologie, CHUV, 1010 Lausanne.
Anne-Karine
AK
Lapointe
Emmanuel
E
Laffitte
D000279:Administration, Cutaneous; D001706:Biopsy; D003879:Dermatologic Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D016460:Granuloma Annulare / Q000175:diagnosis / Q000209:etiology / Q000473:pathology* / Q000628:therapy*; D006105:Granulomatous Disease, Chronic / Q000175:diagnosis / Q000209:etiology / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D010789:Phototherapy / Q000379:methods; D017410:Practice Guidelines as Topic; D012176:Retinoids / Q000008:administration & dosage; D012507:Sarcoidosis / Q000473:pathology / Q000628:therapy; D012871:Skin Diseases / Q000473:pathology / Q000628:therapy; D016559:Tacrolimus / Q000008:administration & dosage; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D012176:Retinoids; D014409:Tumor Necrosis Factor-alpha; D016559:Tacrolimus