[Hypersensitivity pneumonitis caused by Trichoderma viride].
Hypersensitivity pneumonitis (HP) can be induced by exposure to indoor molds contaminating humidifiers and heating or ventilation systems. A 54-year-old woman with dyspnea, cough, chest pain, and fever was seen in the emergency room. A chest radiograph revealed interstitial infiltrates and blood tests showed leukocytosis with neutrophilia and severe hypoxemia. A diagnosis of HP was made by a combination of clinical, radiologic, physiologic, and immunologic studies. Trichoderma viride was isolated in cultures of water samples from an ultrasonic humidifier installed in the patient's home a year earlier. Precipitating immunoglobulin G antibodies to T viride were detected in the patient's serum by enzyme-linked immunosorbent assay. The patient remained symptom free after the humidifier was removed from her home. Our findings strongly suggest that the patient developed HP due to T viride from the humidifier. To our knowledge, this is the first report of such a case.
Departamento de Alergia, Fundación Jiménez Díaz, Madrid, España. aenriquezmatas@hotmail.com
Alicia
A
Enríquez-Matas
Santiago
S
Quirce
Noelia
N
Cubero
Joaquín
J
Sastre
Rosario
R
Melchor
D000389:Air Conditioning / Q000295:instrumentation*; D000542:Alveolitis, Extrinsic Allergic / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000908:Antibodies, Fungal / Q000097:blood; D001993:Bronchodilator Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004417:Dyspnea / Q000209:etiology; D004630:Emergencies; D004866:Equipment Contamination; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D012121:Respiration, Artificial; D014242:Trichoderma / Q000276:immunology; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; D000908:Antibodies, Fungal; D001993:Bronchodilator Agents; D007074:Immunoglobulin G