Laterality of neocortical slow-wave oscillations in anesthetized mice.
In the slow-wave (SW) state, the vast majority of cortical neurons exhibit mostly synchronized oscillatory activity. In this study, we examined the right-left hemispheric difference in slow-wave timings in urethane-anesthetized mice. We found that interhemispheric cross-correlograms of local field potentials (LFPs) peaked asymmetrically. Double in vivo whole-cell patch-clamp recordings also revealed the interhemispheric temporal disparity of slow wave-relevant synaptic barrages. The data suggest the hemispheric laterality in the slow wave origin.
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Genki
G
Minamisawa
Naoya
N
Takahashi
Norio
N
Matsuki
Yuji
Y
Ikegaya
D000200:Action Potentials; D000758:Anesthesia; D000818:Animals; D005625:Frontal Lobe / Q000502:physiology; D007839:Functional Laterality; D008297:Male; D051379:Mice; D019579:Neocortex / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D009778:Occipital Lobe / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology; D018408:Patch-Clamp Techniques; D012894:Sleep Stages / Q000502:physiology; D013569:Synapses / Q000502:physiology