Neuroendocrinology and sexual differentiation in eusocial mammals.
Sexual differentiation of the mammalian nervous system has been studied intensively for over 25 years. Most of what we know, however, comes from work on relatively non-social species in which direct reproduction (i.e., production of offspring) is virtually the only route to reproductive success. In social species, an individual's inclusive fitness may include contributions to the gene pool that are achieved by supporting the reproductive efforts of close relatives; this feature is most evident in eusocial organisms. Here, we review what is known about neuroendocrine mechanisms, sexual differentiation, and effects of social status on the brain and spinal cord in two eusocial mammals: the naked mole-rat and Damaraland mole-rat. These small rodents exhibit the most rigidly organized reproductive hierarchy among mammals, with reproduction suppressed in a majority of individuals. Our findings suggest that eusociality may be associated with a relative lack of sex differences and a reduced influence of gonadal hormones on some functions to which these hormones are usually tightly linked. We also identify neural changes accompanying a change in social and reproductive status, and discuss the implications of our findings for understanding the evolution of sex differences and the neuroendocrinology of reproductive suppression.
Center for Neuroendocrine Studies and Department of Psychology, University of Massachusetts, Amherst, MA 01003, USA.
Melissa M
MM
Holmes
Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA.
Bruce D
BD
Goldman
Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA.
Sharry L
SL
Goldman
Center for Neuroendocrine Studies and Department of Psychology, University of Massachusetts, Amherst, MA 01003, USA.
Marianne L
ML
Seney
Center for Neuroendocrine Studies and Department of Psychology, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: nforger@psych.umass.edu.
Nancy G
NG
Forger
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D009452:Neuroendocrinology; D051381:Rats; D012098:Reproduction / Q000502:physiology; D012727:Sex Characteristics; D019849:Sex Determination Processes; D012726:Sexual Behavior, Animal / Q000502:physiology*; D012919:Social Behavior