Molecular photoacoustic tomography with colloidal nanobeacons.
Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.
C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA. dipanjan@wustl.edu
Dipanjan
D
Pan
Manojit
M
Pramanik
Angana
A
Senpan
Xinmai
X
Yang
Kwang H
KH
Song
Mike J
MJ
Scott
Huiying
H
Zhang
Patrick J
PJ
Gaffney
Samuel A
SA
Wickline
Lihong V
LV
Wang
Gregory M
GM
Lanza
D003102:Colloids; D003287:Contrast Media / Q000737:chemistry*; D005337:Fibrin / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D041622:Tomography, Optical / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*; D014652:Vascular Diseases / Q000175:diagnosis
D003102:Colloids; D003287:Contrast Media; D006046:Gold; D005337:Fibrin