Ure(k)a! Sirtuins Regulate Mitochondria.
Increasing evidence suggests that multiple metabolic pathways are regulated by sirtuin-dependent protein deacetylation in the mitochondria. In this issue, Nakagawa et al. (2009) show that the sirtuin SIRT5 deacetylates and activates a mitochondrial enzyme, carbamoyl phosphate synthetase 1, which mediates the first step in the urea cycle.
Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, 53706, USA.
William C
WC
Hallows
Brian C
BC
Smith
Susan
S
Lee
John M
JM
Denu
D000818:Animals; D002222:Carbamoyl-Phosphate Synthase (Ammonia) / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D037761:Sirtuins / Q000378:metabolism*
D024101:Mitochondrial Proteins; D037761:Sirtuins; D002222:Carbamoyl-Phosphate Synthase (Ammonia)