[Assessment of the state of chromatin from whole blood leucocytes and lymphocyte population and the level of serum immunoglobulins in patients with acute and chronic cerebral ischemia].
A state of chromatin from whole blood leucocytes and lymphocyte population, using an automated method of cytological analysis flow cytofluorometry, and a level of serum IgA, IgG, IgM have been studied in patients with cerebral vascular disorders (chronic cerebral ischemia and cerebral infarction). An analysis of serum immunoglobulin levels did not reveal any significant changes in the groups studied. In patients with chronic cerebral ischemia, the increase of percentage of leucocytes and lymphocytes with activated chromatin, accompanied with the elevated synthesis of nucleic acids and the following elevated synthesis of proteins, including the active enzymes, was found that suggest the involvement of the immune system in the pathogenesis of cerebral ischemia. In patients with ischemic stroke, the percentage of leucocytes with activated chromatin was lower compared to control values that implied the occurrence of immunopathological reaction and role of peripheral blood lymphoid cells in the genesis of anti-inflammatory process in acute cerebral ischemia. The results obtained may be used in elaboration of new approaches to differential pathogenetic therapy of patients with different forms of cerebral blood flow disturbances.
Shukovskiĭ
N V
NV
Sholomov
I I
II
Eliseev
Iu Iu
IuIu
Shukovskaia
T N
TN
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000276:immunology; D002843:Chromatin / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000097:blood*; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment
D002843:Chromatin; D007136:Immunoglobulins