Regeneration: The origin of cancer or a possible cure?
A better understanding of the forces controlling cell growth will be essential for developing effective therapies in regenerative medicine and cancer. Historically, the literature has linked cancer and tissue regeneration-proposing regeneration as both the source of cancer and a method to inhibit tumorigenesis. This review discusses two powerful regeneration models, the vertebrate urodele amphibians and invertebrate planarians, in light of cancer regulation. Urodele limb and eye lens regeneration is described, as well as the planarian's emergence as a molecular and genetic model system in which recent insights begin to molecularly dissect cancer and regeneration in adult tissues.
Oviedo
Néstor J
NJ
Center for Regenerative and Developmental Biology & Department of Biology, Tufts University, Medford, MA 02155-4243, USA. nestor.oviedo@tufts.edu
Beane
Wendy S
WS
D000818:Animals; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy*; D010932:Planarians / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D014562:Caudata / Q000502:physiology