Body mass index and risk of miscarriage in women with recurrent miscarriage.
OBJECTIVE
To investigate the effect of underweight, overweight, and obesity on the risk of miscarriage in the subsequent pregnancy in women with recurrent miscarriage.


METHODS
Retrospective analysis of prospectively collected data from the database of a tertiary recurrent miscarriage center.


METHODS
The recurrent miscarriage clinic at Sheffield Teaching Hospitals.


METHODS
A total of 844 pregnancies from 491 patients with recurrent miscarriage were included in the analysis.


METHODS
The odds of miscarriage in the subsequent pregnancy for all pregnancies after referral to the recurrent miscarriage clinic as well as the first pregnancy post referral.


RESULTS
When analyzing all pregnancies, and compared to women with a normal body mass index, obese and underweight patients had a significantly higher odds of miscarriage in the subsequent pregnancy (OR, 1.71; 95% CI, 1.05-2.8; and OR, 3.98; 95% CI, 1.06-14.92; respectively), whereas there was no significantly increased odds of miscarriage in overweight women (OR, 1.02; 95% CI, 0.72-1.45). Logistic regression analysis showed that the most important factor predicting the occurrence of miscarriage was advanced maternal age (P=0.01) followed by an increased body mass index (P=0.04).


CONCLUSIONS
In women with recurrent miscarriage, a mild increase in the body mass index does not increase the risk of miscarriage, whereas obese and underweight patients have a small but significant increased risk of miscarriage in the subsequent pregnancy.
Metwally
Mostafa
M
The Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield and Sheffield Teaching Hospitals, The Jessop Wing, Sheffield, United Kingdom. m.metwally@sheffield.ac.uk
Saravelos
Sotirios H
SH
Ledger
William L
WL
Li
Tin Chiu
TC
D000026:Abortion, Habitual / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D015992:Body Mass Index; D016208:Databases, Factual / Q000639:trends; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D050177:Overweight / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D011247:Pregnancy; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D013851:Thinness / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*