Cobalt-catalyzed arylzincation of alkynes.
Cobalt(II) bromide catalyzes arylzincation of alkynes with arylzinc iodide x lithium chloride complexes in acetonitrile. The scope of the arylzincation is wide enough to use unfunctionalized alkynes, such as 6-dodecyne, as well as arylacetylenes. The inherent functional group compatibility of arylzinc reagents allows preparation of various functionalized styrene derivatives. The reaction is applicable to the efficient and stereoselective synthesis of a synthetic estrogen and its derivative.
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Kei
K
Murakami
Hideki
H
Yorimitsu
Koichiro
K
Oshima