Validation of the Spanish version of the Liverpool Adverse Events Profile in patients with epilepsy.
The objective of the study was to validate the Spanish version of the Liverpool Adverse Events Profile (LAEP). An observational, cross-sectional, multicenter study was carried out on patients with epilepsy treated with a stable dose of antiepileptic drugs. Patients completed the LAEP, Quality of Life in Epilepsy Inventory-31 (QOLIE-31), and Hospital Anxiety and Depression Scale (HADS). Two hundred sixty-six patients were recruited. The LAEP was completed in a short time, perceived as easy to complete, and there was no relevant information missing. Ceiling/floor effects were negligible. Internal consistency (Cronbach's alpha=0.84) and test-retest reliability (ICC=0.81) were satisfactory. LAEP scores consistently correlated with QOLIE-31 (r=0.71) and HADS (r=0.52-0.63) scores. When the LAEP was used to discriminate between patients with and without adverse events, the scores on the QOLIE and HADS corresponded. The Spanish version of the LAEP scale exhibits adequate psychometric properties, suggesting that it is an appropriate instrument to measure adverse events among Spanish-speaking patients with epilepsy.
Servicio de Neurología, Hospital Clínic i Provicinal de Barcelona, C/Villarroel no 170, Barcelona 08036, Spain. mcarreno@clinic.ub.es
Mar
M
Carreño
Antonio
A
Donaire
Mercè
M
Falip
Iratxe
I
Maestro
Santiago
S
Fernández
Antonio Gil
AG
Nagel
Jose
J
Serratosa
Javier
J
Salas
César
C
Viteri
Jordi
J
Llorens
Eva
E
Baró
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D019370:Observation; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D015203:Reproducibility of Results; D014175:Translating
D000927:Anticonvulsants