[Chemoprevention in head and neck cancer and lung cancer].
Because of their raised prevalence and mortality, association of secondary tumors and inefficiency of therapeutic conventional (surgery, radio- and chemotherapy), head and neck and lung cancers represent true public health problems. The knowledge of the process of carcinogenesis allowed development of approaches of chemoprevention. The vitamin A and its derivatives showed initially a certain efficacy, but an important toxicity and large trials remained negative. For lung cancers, in the event of continuation of the tobacco, beta-carotene and the vitamin A seem even deleterious. Progress in the biology of cancer should allow innovating new approaches of chemoprevention. Today the most effective strategy stays the stop of the tobacco.
Fayette
J
J
Département de Médecine, Centre Léon-Bérard, 28 Rue Laennec, 69008 Lyon, France. fayette@lyon.fnclcc.fr
Kiakouama
L
L
D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics; D020868:Gene Silencing; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000517:prevention & control*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000517:prevention & control*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D016540:Smoking Cessation; D000074606:Smoking Prevention
D016588:Anticarcinogenic Agents; D009363:Neoplasm Proteins; D066246:ErbB Receptors