Galpha(s) uncouples hematopoietic stem cell homing and mobilization.
Defects of hematopoietic stem cell adhesion or migration generally lead to reduced homing to, and enhanced mobilization from, the bone marrow. In a recent publication in Nature, Adams et al. (2009) demonstrate that the guanine-nucleotide-binding stimulatory alpha subunit (Galpha(s)) can, unexpectedly, promote both phenomena.
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Simón
S
Méndez-Ferrer
Paul S
PS
Frenette
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D008954:Models, Biological
D019205:GTP-Binding Protein alpha Subunits, Gs