Long-term effects of infant learning on adult conditioned odor aversion are determined by the last preweaning experience.
We recently showed that odorizing mother's nipples from birth to weaning attenuated adult conditioned odor aversion (COA). The present study evaluated whether shorter durations of preweaning olfactory experiences could induce similar long-term effects. We first showed that late preweaning odorization (PN13-PN25) impaired adult COA similarly to odorization from birth to weaning (PN0-PN25) whereas early odorization (PN0-PN12) had no effect on adult COA. As early odorization was followed by an odorless suckling period, we evaluated whether this odorless suckling could have interfered with early associative learning. We therefore weaned the animals either immediately after early odorization or 7 days later. Early odorization (PN0-PN18) followed by late odorless suckling (PN19-PN25) had no effect on adult COA. However, pups with early odorization (PN0-PN18) but without late odorless suckling (weaned at PN18) showed attenuated COA. These results support the hypothesis that interference between early and late preweaning experiences with the mother determines the long-term impact on adult COA.
Sevelinges
Yannick
Y
Laboratoire de Comportement Neurobiologie et Adaptation CNRS UMR6175, INRA UMR85 Université de Tours, 37380 Nouzilly, France.
Mouly
Anne-Marie
AM
Lévy
Frédéric
F
Ferreira
Guillaume
G
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001245:Association Learning; D001362:Avoidance Learning; D003213:Conditioning, Psychological; D005247:Feeding Behavior; D008568:Memory; D009558:Nipples; D009812:Odorants; D051381:Rats; D013997:Time Factors; D014886:Weaning