Antibiotic therapy of transaxillary augmentation mammoplasty.
BACKGROUND
Capsular contracture is the most common complication and the main cause of dissatisfaction after augmentation mammoplasty, for both the patient and the plastic surgeon. The formation of fibrous tissue around the prosthesis alters the form or the consistency of the implant, thus modifying the breast shape, its contour and its softness. The initial satisfaction with the achieved aesthetical result is then transformed into great dissatisfaction, due to the presence of a shapeless and undesired mass.


METHODS
The following study considered data collected between 1998 and 2007. Sixty-seven female patients (aged between 35 and 53 years) who suffered from mammary hypotrophy and had undergone submuscular augmentation mammoplasty were enrolled. All the implanted prostheses were round and texturized, with a volume of 250 cm3 to 450 cm3. The patients underwent pre-, intra- and postoperative antibiotic therapy in order to prevent clinical and subclinical infection of the implants.


RESULTS
The follow-up ranged from a period of two to nine years. All patients were examined during the first antibiotic administration and again subsequently, after 1, 3, 6 and 12 months, to evaluate the results in terms of capsular contracture. Of all patients, 90% presented a degree I Baker's classification, the remaining 10% a degree II. Not one of the patients treated showed grade III or IV capsular contracture nor was there any need to remove the prosthesis during the examination period.


CONCLUSIONS
It is clear that a main role in capsular contracture is played by the infectious process, with the activation of specific inflammatory cells. Interfering with the infectious process can prevent fibrotic reaction evolving into capsular contracture. Although the process causing capsular contracture is multifactorial, our study showed a favourable response can be achieved when using antibiotic therapy associated with the transaxillary approach.
Department of Plastic and Reconstructive Surgery, University of Rome La Sapienza, Policlinico Umberto I, Viale del Policlinico, 155, 00161-Rome, Italy.
B
B
Carlesimo
E
E
Cigna
P
P
Fino
A
A
Rusciani
F
F
Tariciotti
S
S
Staccioli
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001940:Breast / Q000473:pathology*; D019928:Breast Implantation / Q000009:adverse effects; D018427:Breast Implants / Q000009:adverse effects; D005260:Female; D005549:Foreign-Body Reaction / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007249:Inflammation; D016462:Mammaplasty / Q000009:adverse effects*; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents