[Effect of alpha/beta-interferon on electrophoretic mobility of murine T-lymphocytes].
Alpha/beta-Interferon (alpha/beta-IFN)-induced early changes in the electrophoretic mobility (EPM) of murine splenic T lymphocytes were studied by the microelectrophoresis technique. It has been found that alpha/beta-IFN-treated T lymphocytes have a greater EPM than control cells within first hours of alpha/beta-IFN addition. This change in EPM depends on the concentration of alpha/beta-IFN in the medium and the duration of alpha/beta-IFN interaction with the cells. It is concluded that the alpha/beta-IFN-treated cells have a greater net negative charge of the cell surface than control cells.
O V
OV
Dolha
N M
NM
Zholobak
M Ia
MIa
Spivak
I S
IS
Mahura
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004586:Electrophoresis; D016898:Interferon-alpha / Q000494:pharmacology*; D016899:Interferon-beta / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D011956:Receptors, Cell Surface / Q000378:metabolism; D013154:Spleen / Q000166:cytology; D013499:Surface Properties; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D013997:Time Factors
D016898:Interferon-alpha; D011956:Receptors, Cell Surface; D016899:Interferon-beta