Blood culture status in mature horses with diarrhoea: a possible association with survival.
BACKGROUND
The incidence and implications of positive blood cultures in mature horses with diarrhoea is unknown. The diagnosis of bacteraemia may alter treatment and prognosis.


OBJECTIVE
The proportion of horses with diarrhoea that are blood culture positive is higher than previously assumed and a positive blood culture has a negative impact on survival.


METHODS
Blood cultures were taken at admission and 24 h after admission from 31 mature horses with diarrhoea.


RESULTS
Nine (29%) horses were blood culture positive within 24 h of admission. Organisms isolated included Corynebacterium spp. (n = 6), Streptococcus spp. (n = 2), Pantoea agglomerans (n = 1), Gram-negative rod (n = 1), Bacillus spp. (n = 1) and yeast (n = 1). Horses with positive blood cultures were significantly less likely to survive. Prior treatment with antimicrobial drugs had no significant effect on blood culture status. Horses with positive blood cultures had a significantly higher heart rate, packed cell volume (PCV) and plasma potassium concentration at admission, and a higher PCV and lower total plasma protein concentration 24 h after admission.


CONCLUSIONS
Positive blood cultures occur more frequently than previously reported, and may have a negative impact on survival in horses with diarrhoea.


CONCLUSIONS
Results of blood cultures may be useful in formulating a prognosis for horses with diarrhoea. Further research is required to determine the effect of antimicrobial treatment on outcome.
Johns
I
I
Section of Medicine, Department of Clinical Studies-New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Road, Kennett Square, Pennsylvania 19348, USA.
Tennent-Brown
B
B
Schaer
B Dallap
BD
Southwood
L
L
Boston
R
R
Wilkins
P
P
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001407:Bacillus / Q000302:isolation & purification; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality / Q000662:veterinary*; D015897:Comorbidity; D003352:Corynebacterium / Q000302:isolation & purification; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality / Q000662:veterinary*; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006339:Heart Rate / Q000502:physiology; D006400:Hematocrit / Q000662:veterinary; D006734:Horse Diseases / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality*; D006736:Horses; D008297:Male; D020636:Pantoea / Q000302:isolation & purification; D011188:Potassium / Q000097:blood; D015995:Prevalence; D011379:Prognosis; D013291:Streptococcus / Q000302:isolation & purification; D016019:Survival Analysis; D016896:Treatment Outcome; D015003:Yeasts / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D011188:Potassium