An improved synthesis of alpha,beta-unsaturated nitrones relevant to the stephacidins and analogs thereof.
A new method is reported for the synthesis of the alpha,beta-unsaturated nitrone moiety characteristic of the stephacidin/avrainvillamide family of bioactive prenylated indole alkaloids. Application to the synthesis of stephacidin analogs and a potential biological probe are showcased.
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
Benjamin D
BD
Hafensteiner
María
M
Escribano
Elena
E
Petricci
Phil S
PS
Baran
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D026121:Indole Alkaloids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry; D009589:Nitrogen Oxides / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction
D000970:Antineoplastic Agents; D026121:Indole Alkaloids; D007211:Indoles; D009589:Nitrogen Oxides; C480558:avrainvillamide; C015388:nitrones