IGF2R missense single-nucleotide polymorphisms and breast cancer risk: the multiethnic cohort study.
IGF2R has been proposed to be a tumor suppressor gene given its antagonist role on cellular growth and evidence of loss of heterozygosity in several cancers, including breast cancer. To investigate whether inherited differences in potentially functional IGF2R variants influence the risk of breast cancer, we sequenced 46 exons of IGF2R to identify novel missense single-nucleotide polymorphisms (SNP) and tested 12 missense SNPs for their associations with breast cancer risk among 1,614 breast cancer cases and 1,960 controls from the Multiethnic Cohort. None of these missense SNPs were significantly associated with breast cancer risk. Our findings provide no evidence that missense SNPs in IGF2R influence breast cancer susceptibility
Cheng
Iona
I
Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA. icheng@crch.hawaii.edu
Stram
Daniel O
DO
Burtt
Noël P
NP
Gianniny
Lauren
L
Garcia
Rachel R
RR
Pooler
Loreall
L
Henderson
Brian E
BE
Le Marchand
Loïc
L
Haiman
Christopher A
CA
D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005006:Ethnicity; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020125:Mutation, Missense; D020641:Polymorphism, Single Nucleotide; D017527:Receptor, IGF Type 2 / Q000235:genetics*
D017527:Receptor, IGF Type 2