Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery.
Extreme makeover of cholesterol: Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the bilayer. Thus, disterolphospholipids (e.g. 1) are valuable new components for liposome formulation.
Huang
Zhaohua
Z
Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, CA 94143-0912, USA.
Jaafari
Mahmoud Reza
MR
Szoka
Francis C
FC
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D008081:Liposomes / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D010743:Phospholipids / Q000138:chemical synthesis / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D010743:Phospholipids; D004317:Doxorubicin