[Evaluation of C-reactive protein levels in serum and gingival crevicular fluid in type 2 diabetes patients with periodontitis].
OBJECTIVE
To observe the relationship of the C-reactive protein (CRP) levels and the severity of the periodontal inflammation and the diabetes glycemic control.


METHODS
The CRP levels in serum and in gingival crevicular fluid(GCF) in type 2 diabetes patients with chronic periodontitis, patients with periodontitis alone, patients with type 2 diabetes alone and healthy people were assayed. Glycosylated hemoglobin (HbAlc) in serum was detected. Probing depth (PD) and sulcus bleeding index (SBI) were recorded. The data were analyzed by non-paired t test and Spearman correlation analysis with SPSS 10.0 software package.


RESULTS
The serum CRP levels in type 2 diabetes patients with periodontitis and periodontitis and type 2 diabetes were significantly higher than those in healthy group(P<0.01). Serum CRP levels in type 2 diabetes patients with periodontitis were the highest and were significantly higher than that in periodontitis group(P<0.01) and type 2 diabetes group(P<0.05). However, the CRP levels in GCF in each group were far lower than those in serum and no difference was detected in the four groups (P>0.05). The CRP levels in serum didn't correlate to the CRP levels in GCF (P>0.05).The CRP levels in serum correlated to PD, SBI and HbAlc(P<0.01).


CONCLUSIONS
CRP may be involved in the interaction of chronic periodontitis and type 2 diabetes. The CRP levels in GCF could not reflect the inflammation of the periodontitis or the condition of diabetes.
Department of Stomatology, Third People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China. wuchunlan9229@163.com
Chun-Lan
CL
Wu
Feng-Ling
FL
Chen
D002097:C-Reactive Protein; D055113:Chronic Periodontitis; D003924:Diabetes Mellitus, Type 2; D005883:Gingival Crevicular Fluid; D006801:Humans; D010518:Periodontitis
D002097:C-Reactive Protein