Biotransformation of methyl cholate by Aspergillus niger.
Biotransformation of methyl cholate using Aspergillus niger was investigated. This led to the isolation of two derivatives: methyl 3alpha,7alpha,12alpha,15beta-tetrahydroxy-5beta-cholan-24-oate identified as a new compound, and a known compound methyl 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate. The structure elucidation of the new compound was achieved using 1D and 2D NMR, MS and X-ray diffraction.
Al-Aboudi
Amal
A
Chemistry Department, University of Jordan, 1194 Amman, Jordan. alaboudi@ju.edu.jo
Mohammad
Mohammad Y
MY
Haddad
Salim
S
Al-Far
Rawhi
R
Choudhary
M Iqbal
MI
Atta-Ur-Rahman
D001234:Aspergillus niger / Q000378:metabolism*; D001711:Biotransformation; D020355:Cholates / Q000737:chemistry / Q000378:metabolism*; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
D020355:Cholates; C037034:methyl cholate