Iron-promoted cyclization/halogenation of alkynyl diethyl acetals.
FeCl(3)- and FeBr(3)-promoted cyclization/halogenation of alkynyl diethyl acetals has been efficiently realized, selectively affording (E)-2-(1-halobenzylidene or alkylidene)-substituted five-membered carbo- and heterocycles which were then efficiently transformed to vinylarenes by Suzuki coupling. The present protocol has provided a new alternative route to vinylic C-Cl and C-Br bond formation.
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning 116023, PR China.
Tongyu
T
Xu
Zhengkun
Z
Yu
Liandi
L
Wang