Cytokines profiles in Sudanese women with preeclampsia.
BACKGROUND
Cytokine imbalance in preeclampsia may be one of the etiological factors for preeclampsia.


OBJECTIVE
The study was conducted to investigate interferon gamma (IFN-gamma), interleukin-4 (IL-4) and interleukin-10 (IL-10) in preeclampsia. Enzyme-linked immunosorbent assay (ELISA) was used to measure the concentrations of these three pro-inflammatory cytokines in sera from 33 Sudanese women with preeclampsia (at presentation and 7 days later) and 32 women with normal pregnancy as a control group.


RESULTS
The levels of IFN-gamma and IL-4 were slightly--not statistically significant--higher in the women with preeclampsia. IL-10 was significantly higher in the women with preeclampsia. Women with preeclampsia had significantly lower levels of IFN-gamma and IL-4 and significantly higher levels of IL-10 7 days later in comparison with the presenting levels.


CONCLUSIONS
Thus, the significantly raised levels of IL-10 in women with preeclampsia suggest its role in pathogenesis of preeclampsia, and further research is needed.
Faculty of Medicine, University of Khartoum, Sudan.
Khalid H
KH
Bakheit
Nada K
NK
Bayoumi
Ahmed M
AM
Eltom
Mustafa I
MI
Elbashir
Ishag
I
Adam
D000328:Adult; D044383:Black People; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology; D011247:Pregnancy; D013397:Sudan; D055815:Young Adult
D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma