Effects of acute treatment with amphetamine in locomotor activity in sepsis survivor rats.
We here evaluated the central dopaminergic response in sepsis survivor rats using the administration of D-amphetamine. Male Wistar rats underwent cecal ligation and perforation (CLP) or were sham-operated. After 10 days of recovery, rats received an intraperitoneal injection of D-amphetamine 0.5, 1 and 2 mg/kg or saline, and were subjected to the open field test. We did not observe alterations in locomotor and exploratory activities in CLP compared to sham group. Treatment with amphetamine 0.5 mg/kg did not have effect in sham and CLP groups; D-amphetamine 1 mg/kg increased locomotor and exploratory activities only in sham group, and D-amphetamine 2 mg/kg increased in both sham and CLP groups. We suggest that, in part, dopamine pathway may be altered in sepsis.
Comim
Clarissa M
CM
Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil.
Constantino
Larissa S
LS
Petronilho
Fabrícia
F
de Souza
Bruna
B
Barichello
Tatiana
T
Quevedo
João
J
Dal-Pizzol
Felipe
F
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000401:mortality / Q000503:physiopathology*
D000661:Amphetamine; D004298:Dopamine