Evaluation of relaxin's antifibrotic action by SELDI-TOF mass spectrometry-based profiling of relaxin knockout mice, a model of progressive fibrosis.
Surface-enhanced laser desorption ionization-time-of-flight mass spectrometry was employed to identify potential biomarkers for early-onset fibrosis. These biomarkers were then used to evaluate the efficacy of relaxin to reverse or ameliorate the development of the condition.
Giannakis
Eleni
E
Howard Florey Institute, University of Melbourne, Victoria 3010, Australia.
Macris
Mary
M
Chan
Linda
L
Tregear
Geoffrey W
GW
Samuel
Chrishan S
CS
Wade
John D
JD
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D005355:Fibrosis / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation / Q000187:drug effects*; D051379:Mice; D018345:Mice, Knockout; D012065:Relaxin / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
D015415:Biomarkers; D012065:Relaxin