Hypoglycemic effect of the total flavonoid fraction from folium Eriobotryae.
The antidiabetic effect of the total flavonoids fraction from leaves of Eriobotrya japonica (EJF) was evaluated through normal and streptozotocin-induced diabetic mice with graded oral doses of 150, 300, 450 mg/kg for 7 days or 14 days. The result showed that the dose of 300 mg/kg and 450 mg/kg resulted significant hypoglycemic effect on normal mice, the dose of 300 mg/kg induced significant decrease in plasma glucose concentration (PGC), glycosylated serum protein (GSP), total cholesterol (TC) and triglyceride (TG), and significant increase in superoxide dismutase (SOD) activity and serum insulin level in streptozotocin-diabetic mice. These results suggested that EJF has hypoglycemic potential.
Institute of Botany, Jiangsu Province and the Chinese Academy of Sciences, Nanjing 210014, Jiangsu, PR China.
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Lü
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Chen
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Li
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Ren
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Wu
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Zhang
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D031983:Eriobotrya / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification / Q000627:therapeutic use*; D006023:Glycoproteins / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000032:analysis*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013482:Superoxide Dismutase / Q000097:blood; D000093422:Glycated Serum Proteins
D001786:Blood Glucose; D001798:Blood Proteins; D005419:Flavonoids; D006023:Glycoproteins; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D013482:Superoxide Dismutase; D000093422:Glycated Serum Proteins