Phactr2 and Parkinson's disease.
Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P=0.032), Canadian (OR: 1.41, P=0.014) and Irish (OR: 1.44, P=0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P=0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P<0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Christian
C
Wider
Sarah J
SJ
Lincoln
Michael G
MG
Heckman
Nancy N
NN
Diehl
Jeremy T
JT
Stone
Kristoffer
K
Haugarvoll
Jan O
JO
Aasly
J Mark
JM
Gibson
Timothy
T
Lynch
Alex
A
Rajput
Michele L
ML
Rajput
Ryan J
RJ
Uitti
Zbigniew K
ZK
Wszolek
Matthew J
MJ
Farrer
Owen A
OA
Ross
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008840:Microfilament Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009664:Norway / Q000453:epidemiology; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult
D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; C543104:PHACTR2 protein, human