Cytotoxic and HLE-inhibitory tetramic acid derivatives from marine-derived fungi.
Tetramic acid derivatives are an important class of nitrogen heterocycles with a pyrrolidine-2,4-dione core as a key structural motif. From the sponge-derived fungus Beauveria bassiana, a new equisetin-like tetramic acid derivative, beauversetin (1), was isolated. The sea weed-derived fungus Microdiplodia sp. produced the tetramic acid derivative 2 (Sch210972) which was shown to inhibit human leucocyte elastase (HLE) with an IC50 of 1.04 microg mL(-1).
Neumann
Kerstin
K
Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.
Kehraus
Stefan
S
Gütschow
Michael
M
König
Gabriele M
GM
D000818:Animals; D003497:Cyclic N-Oxides / Q000032:analysis* / Q000302:isolation & purification* / Q000633:toxicity; D006999:Hypocreales / Q000737:chemistry*; D019272:Leukocyte Elastase / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000382:microbiology*; D011760:Pyrrolidinones / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity
D003497:Cyclic N-Oxides; D011760:Pyrrolidinones; C009435:tetramic acid; D019272:Leukocyte Elastase