Exploratory assessment of perfluorinated compounds and human thyroid function.
Thyroid hormones play critical roles in human neurodevelopment and adult neurocognitive function. Persistent organohalogen pollutants, such as perfluorinated compounds (PFCs), may interfere with thyroid homeostasis and thus exposures to these compounds might represent risk factors for neurologic and cognitive abnormalities. In this study, serum specimens collected from thirty-one licensed anglers in New York State were analyzed for levels of thyroid stimulating hormone (TSH), free thyroxine (FT(4)), perfluorodecanoic acid (PFDA), perfluorononanoic acid (PFNA), perfluoroheptanoic acid (PFHpA), perfluorohexanesulfonate (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), perfluorooctanesulfonamide (PFOSA), and perfluoroundecanoic acid (PFUnDA). PFOS and PFOA occurred in the highest concentrations with geometric means of 19.6 ng/mL (95% CI 16.3-23.5) and 1.3 ng/mL (95% CI 1.2-1.5), respectively. In a cross-sectional analysis, no statistically significant associations were detected for PFCs, or their sum, with TSH or FT(4) at alpha=0.05. However, post hoc power analyses, though limited, suggested that moderate increases in sample size, to 86 and 129 subjects, might facilitate 80% power to detect statistically significant associations for FT(4) and PFDA (beta=0.09) and PFUnDA (beta=0.08), respectively. The consumption of sportfish may have contributed to PFDA (r=0.52, P=0.003) and PFUnDA (r=0.40, P=0.025) levels. This preliminary study does not indicate associations between non-occupational PFCs exposures and thyroid function. However, the possibility for weak associations for FT(4) with PFDA and PFUnDA, PFCs measured in low concentrations, is raised. Given the ubiquity of PFCs in the environment and the importance of thyroid function to neurodevelopmental and neurocognitive endpoints, a confirmatory study is warranted.
Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, New York 12114, USA. mbloom@albany.edu
Michael S
MS
Bloom
Kurunthachalam
K
Kannan
Henry M
HM
Spliethoff
Lin
L
Tao
Kenneth M
KM
Aldous
John E
JE
Vena
D000328:Adult; D017738:Alkanesulfonic Acids / Q000097:blood; D000704:Analysis of Variance; D002210:Caprylates / Q000097:blood; D003652:Decanoic Acids / Q000097:blood; D004784:Environmental Monitoring / Q000379:methods; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009518:New York; D012044:Regression Analysis; D012189:Retrospective Studies; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D017738:Alkanesulfonic Acids; D002210:Caprylates; D003652:Decanoic Acids; D004785:Environmental Pollutants; D005466:Fluorocarbons; C036567:perfluorodecanoic acid; C073608:perfluorooctane; D013972:Thyrotropin; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid; D013974:Thyroxine