Central airways obstruction due to Aspergillus fumigatus after lung transplantation.
Aspergillus fumigatus may affect immunocompromised lung transplant patients in many ways. We report a new pulmonary manifestation of A fumigatus in 3 patients who underwent bilateral lung transplantation. All 3 subjects developed rapid decreases in pulmonary function and were found to have large central airways obstruction with thick plugs of mucus, heavily laden with Aspergillus species. All 3 patients presented with atypical features of Aspergillus infection, but all responded to treatments with either steroids, anti-fungals or both.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Elizabeth
E
Cerceo
Robert M
RM
Kotloff
Denis
D
Hadjiliadis
Vivek N
VN
Ahya
Alberto
A
Pochettino
Colin
C
Gillespie
Jason D
JD
Christie
D000402:Airway Obstruction / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D000935:Antifungal Agents / Q000627:therapeutic use*; D001232:Aspergillus fumigatus; D001999:Bronchoscopy; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D016040:Lung Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use*; D055732:Pulmonary Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery*; D014797:Vital Capacity / Q000187:drug effects
D000935:Antifungal Agents; D005938:Glucocorticoids; D017964:Itraconazole; D011241:Prednisone