Anterior ocular biometry using 3-dimensional optical coherence tomography.
OBJECTIVE
To evaluate anterior ocular biometry by comparing the measurements of central corneal thickness (CCT) and anterior chamber depth (ACD) with 3-dimensional corneal and anterior segment optical coherence tomography (CAS-OCT) and other methods.


METHODS
Cross-sectional study.


METHODS
Forty eyes of 40 normal subjects.


METHODS
The CCT was measured by 4 methods (CAS-OCT, Scheimpflug camera, scanning-slit topography, and ultrasonic pachymetry), and the ACD was measured by 3 methods (CAS-OCT, Scheimpflug camera, and scanning-slit topography). The anterior chamber volume (ACV) was calculated with CAS-OCT. Repeatability and reproducibility of CAS-OCT measurements were evaluated.


METHODS
The CCT and ACD were measured and compared between devices. The ACV was calculated with CAS-OCT. Coefficient of variation and intraclass correlation coefficient (ICC) were calculated to evaluate repeatability and reproducibility of CAS-OCT measurements.


RESULTS
The mean CCT was 547.0+/-39.0, 590.0+/-39.8, 525.0+/-45.0, and 545.0+/-40.3 microm with CAS-OCT, Scheimpflug camera, scanning-slit topography, and ultrasonic pachymetry, respectively. Significant differences were observed among the 4 methods (P<0.0001; 1-way analysis of variance [ANOVA]). The CCT measured with Scheimpflug camera was significantly larger than those measured with the other methods (P<0.0001; Bonferroni multiple comparison), but there was no significant difference among the other 3 methods. The mean ACD was 3.01+/-0.47, 3.04+/-0.52, and 2.88+/-0.50 mm with CAS-OCT, Scheimpflug camera, and scanning-slit topography, respectively. There was no significant difference among the 3 methods (P = 0.678; 1-way ANOVA). A significant linear correlation in CCT and ACD were observed between CAS-OCT and other methods (all P<0.0001). The mean ACV calculated with CAS-OCT was 169.7+/-23.1 mm(3). The coefficient of repeatability and reproducibility of CCT and ACD measurements were <5% and ICCs were >0.98.


CONCLUSIONS
The CCT measurements were comparable among CAS-OCT, ultrasonic pachymetry, and scanning-slit topography, but Scheimpflug camera yielded a significantly higher CCT value. There was no significant difference in ACD measurements among CAS-OCT, Scheimpflug camera, and scanning-slit topography. The ACV was noninvasively measured by CAS-OCT.


BACKGROUND
The authors have no proprietary or commercial interest in any materials discussed in this article.
Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, Japan. Caesar.ShihTzu@gmail.com
Shinichi
S
Fukuda
Keisuke
K
Kawana
Yoshiaki
Y
Yasuno
Tetsuro
T
Oshika
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000033:anatomy & histology; D001699:Biometry / Q000379:methods*; D003315:Cornea / Q000033:anatomy & histology*; D019781:Corneal Topography / Q000379:methods; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010781:Photography / Q000379:methods; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult