Current understanding of the mechanisms involved in metabolic detoxification of warfare nerve agents.
This study reviews current understanding of chemical, biochemical and toxicological aspects and mechanisms of metabolism of warfare nerve agents. Among enzymes participating in metabolism of nerve agents the role of A-esterases, serum cholinesterase and carboxylesterases is discussed. This article also discusses other aspects of metabolism of the agents such as protein binding and the role of tissue depots for these compounds.
Jokanović
Milan
M
Experta Consulting, Nehruova 57, 11070 Belgrade, Serbia. milan.jokanovic@gmail.com
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D043182:Carboxylesterase / Q000378:metabolism; D002619:Chemical Warfare Agents / Q000493:pharmacokinetics* / Q000633:toxicity*; D002802:Cholinesterases / Q000097:blood; D004950:Esterases / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D008658:Inactivation, Metabolic; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics* / Q000633:toxicity*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D014018:Tissue Distribution
D002619:Chemical Warfare Agents; D009943:Organophosphorus Compounds; D012709:Serum Albumin; D004950:Esterases; D043182:Carboxylesterase; D002802:Cholinesterases