The significance of bone marrow cell morphology and its correlation with cytogenetic features in the diagnosis of MDS-RA patients.
Besides cytopenia, dysplasia is crucial characteristic of MDS-RA. To summarize the morphological features that contribute to the diagnosis of MDS-RA, 48 RA patients with abnormal karyotype were analyzed for the features of morphological and cytogenetical abnormalities and the relationships between them. 46 MDS-RA patients with normal karyotype and 207 patients with non-MDS anemia were enrolled into control groups. More conspicuous and diverse dysplasia can be found in abnormal karyotype MDS-RA than those in control groups (P<0.05). Apparent dysplasia in granulocyte and megakaryocytoid lineages may provide valuable evidence for the diagnosis. Dysplasia occurred more frequently in patients with severe chromosome abnormalities.
The First Affiliated Hospital of Soochow University, Leukemia Research Division, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou, PR China.
Dandan
D
Liu
Zixing
Z
Chen
Yongquan
Y
Xue
Dingwei
D
Lu
Youning
Y
Zhou
Jingxia
J
Gong
Weilin
W
Wu
Jianying
J
Liang
Qinfen
Q
Ma
Jinlan
J
Pan
Yafang
Y
Wu
Yong
Y
Wang
Jun
J
Zhang
Juan
J
Shen
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000473:pathology*; D001854:Bone Marrow Cells / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D012189:Retrospective Studies