First ultrasound-mediated one-pot synthesis of N-substituted amides.
Ultrasound irradiation, an efficient and innocuous technique of reagent activation for synthesizing organic compounds, has been applied with success to transform seven carboxylic acids to fourteen secondary amides in good to excellent yields. The reaction has worked well either with aryl or alkyl carboxylic acids as well as with aromatic or aliphatic amines. This methodology is expeditious and reliable for preparing secondary carboxamides which in many cases are embedded in the C-5 side-chain of 1,2,4-oxadiazoles (14, 15, 17-27). The elemental analyses of new compounds (19-27) in conjunction with the spectral data of all synthesized amides gave an idea about their structures, while the crystallographic data of one of the compounds (26) supplied information concerning the configurational behavior of the amidic part and also the conformational aspect of the entire molecule in the crystalline state.
Departamento de Quimica Fundamental, Universidade Federal de Pernambuco, 50.740-540 Recife, PE, Brazil. rms_indu@yahoo.com
Rajendra M
RM
Srivastava
Ricardo A W
RA
Neves Filho
Cecilia A
CA
da Silva
Adailton J
AJ
Bortoluzzi
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry; D007700:Kinetics; D009584:Nitrogen / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry; D014465:Ultrasonics
D000577:Amides; D002254:Carbonates; D007202:Indicators and Reagents; C037593:potassium carbonate; D009584:Nitrogen; D011188:Potassium