Long remission in muscle-specific kinase antibody-positive juvenile myasthenia.
The clinical course of anti-muscle specific kinase-positive myasthenia in children has been little reported. Described here is the case of an 8 year-old boy who presented with ptosis and generalized weakness, which resolved within 1 month without any immunomodulatory treatment. This spontaneous remission lasted 6 years and was then followed by a relapse with bulbar symptoms. The patient was put on plasmapheresis; after initial benefit, symptoms worsened and serum antibody levels persisted. This case constitutes an example of the variability of the clinical presentation, course, and therapeutic response in anti-muscle specific kinase-positive myasthenia in childhood.
Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey. banlar@hacettepe.edu.tr
Banu
B
Anlar
Vuslat
V
Yilmaz
Güher
G
Saruhan-Direskeneli
D000906:Antibodies / Q000097:blood*; D002648:Child; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000097:blood* / Q000276:immunology*; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*; D012008:Recurrence
D000906:Antibodies; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases