Hamartomatous polyposis syndromes.
Hamartomatous polyposis syndromes are a diverse group of inherited conditions grouped together because they exhibit hamartomatous rather than epithelial polyp histology. Each syndrome exhibits characteristic polyp histology, gastrointestinal polyp distribution, gastrointestinal cancer risks, extra-intestinal benign findings and often extra-intestinal cancer risks. Identifying individuals at risk for these syndromes and accurately defining the precise diagnosis are necessary for planning surveillance and management in order to prevent the benign and malignant complications. Characteristic syndrome features including gastrointestinal findings, pathology, genetics, and management options for the three most common hamartomatous polyposis syndromes, Peutz-Jeghers syndrome, PTEN hamartoma tumour syndrome, and juvenile polyposis will be presented in this review.
Gammon
Amanda
A
Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112-5550, USA. amanda.gammon@hci.utah.edu
Jasperson
Kory
K
Kohlmann
Wendy
W
Burt
Randall W
RW
D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D009154:Mutation; D010580:Peutz-Jeghers Syndrome / Q000175:diagnosis* / Q000235:genetics; D010641:Phenotype; D011237:Predictive Value of Tests