Suppression of cytochrome P450 1A1 expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse hepatoma hepa-1c1c7 cells treated with serum of (-)-epigallocatechin-3-gallate- and green tea extract-administered rats.
The suppression of cytochrome P450 1A1 (CYP1A1) expression was examined in mouse hepatoma Hepa-1c1c7 cells treated with serum prepared from (-)-epigallocatechin-3-gallate- and green tea extract-administered rats. Catechins were found in the rat plasma after the administration. In Hepa-1c1c7 cells, 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 expression was suppressed by treatment with the rat serum. It is concluded that catechins can possibly modulate CYP1A1 expression.
Fukuda
Itsuko
I
Research Center for Food Safety and Security, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan. itsuko@silver.kobe-u.ac.jp
Tsutsui
Miki
M
Sakane
Iwao
I
Ashida
Hitoshi
H
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000473:pathology*; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D045744:Cell Line, Tumor; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism*; D015536:Down-Regulation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D051381:Rats; D013662:Tea / Q000737:chemistry*
D010936:Plant Extracts; D000072317:Polychlorinated Dibenzodioxins; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; D019363:Cytochrome P-450 CYP1A1