Socioeconomic status, antioxidant micronutrients, and correlates of oxidative damage: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
OBJECTIVE
To examine whether socioeconomic status (SES) (education, occupation, income), is associated both cross sectionally and prospectively with circulating concentrations of a) two correlates of oxidative damage, F(2)-isoprostanes (F(2)-IsoPs) and gamma-glutamyltransferase (GGT); and b) antioxidant nutrients (ascorbic acid and carotenoids). We also examine whether the proposed associations are mediated by smoking, alcohol consumption, and depression. Risk for chronic disease increases with decreasing SES. One pathway by which low SES might influence disease risk is by promoting oxidative stress.


METHODS
Data from 1278 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study were used to examine the association of SES with oxidation correlates and antioxidant nutrients. Education, occupation, health behaviors, and body mass index (BMI) were assessed during Years 0, 10, and 15 of the study; income and depression were evaluated at Years 10 and 15. F(2)-isoprostanes were measured at Year 15, gamma-glutamyltransferase (GGT) at Years 0 and 10, carotenoids at Years 0 and 15, and ascorbic acid at Years 10 and 15.


RESULTS
Cross sectionally, oxidation correlates decreased and antioxidant nutrients increased with increasing SES, estimated in several ways, independent of age, sex, race, and BMI. Prospectively, lower Year 0 education and occupation predicted greater increases in GGT and greater decreases in carotenoids over 10 to 15 years. Prospective associations of Year 0 SES with Year 15 carotenoids were independent of Year 15 SES. Smoking, drinking, and depression symptoms partially mediated these effects.


CONCLUSIONS
Circulating oxidation correlates increase and antioxidant nutrients decrease with decreasing SES, both cross sectionally and prospectively.
Department of Psychology,Caregie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA. djanicki@andrew.cmu.edu
Denise
D
Janicki-Deverts
Sheldon
S
Cohen
Karen A
KA
Matthews
Myron D
MD
Gross
David R
DR
Jacobs
D000293:Adolescent; D000428:Alcohol Drinking / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002338:Carotenoids / Q000097:blood / Q000378:metabolism; D003327:Coronary Disease / Q000175:diagnosis* / Q000453:epidemiology* / Q000378:metabolism; D003331:Coronary Vessels / Q000378:metabolism; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D007182:Income; D008137:Longitudinal Studies; D008297:Male; D018977:Micronutrients / Q000097:blood / Q000378:metabolism*; D018384:Oxidative Stress; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking; D012923:Social Class; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000378:metabolism
D000975:Antioxidants; D015415:Biomarkers; D018977:Micronutrients; D002338:Carotenoids; D005723:gamma-Glutamyltransferase; D001205:Ascorbic Acid