Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots.
A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.
Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
Hak Soo
HS
Choi
Binil Itty
BI
Ipe
Preeti
P
Misra
Jeong Heon
JH
Lee
Moungi G
MG
Bawendi
John V
JV
Frangioni
D000818:Animals; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism; D050997:Nanomedicine; D010179:Pancreas / Q000378:metabolism; D011092:Polyethylene Glycols / Q000378:metabolism; D045663:Quantum Dots; D051381:Rats; D017207:Rats, Sprague-Dawley; D019265:Spectroscopy, Near-Infrared; D014018:Tissue Distribution
D011092:Polyethylene Glycols