Improvement of congestive heart failure after octreotide and transsphenoidal surgery in a patient with acromegaly.
A 59-year-old man was admitted because of congestive heart failure. He was suspected to have acromegaly, and magnetic resonance imaging revealed a pituitary macroadenoma. Endocrine examination revealed elevated plasma levels of growth hormone (GH) and insulin-like growth factor (IGF)-1, and an oral glucose tolerance test failed to suppress plasma GH levels, consistent with the diagnosis of GH-producing pituitary tumor. Treatment with octreotide, followed by transsphenoidal surgery resulted in normalization of plasma GH/IGF-1 levels, accompanied by the improvement of cardiac function. Thus, it is suggested that excess GH/IGF-1 axis is involved in the development of acromegaly-related cardiomyopathy in the present case.
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo.
Itaru
I
Akaza
Kyoichiro
K
Tsuchiya
Miho
M
Akaza
Toru
T
Sugiyama
Hajime
H
Izumiyama
Masaru
M
Doi
Takanobu
T
Yoshimoto
Yukio
Y
Hirata
D000172:Acromegaly / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D011859:Radiography; D013101:Sphenoid Sinus / Q000000981:diagnostic imaging / Q000601:surgery
D015282:Octreotide