Functional MRI study of specific animal phobia using an event-related emotional counting stroop paradigm.
BACKGROUND
Emotional interference tasks may be useful in probing anterior cingulate cortex (ACC) function to understand abnormal attentional study in individuals with specific phobia.


METHODS
In a 3 T functional MRI study, individuals with specific phobias of the animal subtype (SAP, n=12) and healthy comparison (HC) adults (n=12) completed an event-related emotional counting Stroop task. Individuals were presented phobia-related, negative, and neutral words and were instructed to report via button press the number of words displayed on each trial.


RESULTS
Compared to the HC group, the SAP group exhibited greater rostral ACC activation (i.e., greater response to phobia-related words than neutral words). In this same contrast, HCs exhibited greater right amygdala and posterior insula activations as well as greater thalamic deactivation than the SAP group. Both groups exhibited anterior cingulate, dorsomedial prefrontal cortex, inferior frontal gyrus/insula, and amygdala activations as well as thalamic deactivation. Psychophysiological interaction analysis highlighted a network of activation in these regions in response to phobia-related words in the SAP group.


CONCLUSIONS
Taken together, these findings implicate a circuit of dysfunction, which is linked to attention abnormalities in individuals with SAP.
Psychiatric Neuroimaging Research Program and Martinos Biomedical Imaging Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Jennifer C
JC
Britton
Andrea L
AL
Gold
Thilo
T
Deckersbach
Scott L
SL
Rauch
D000328:Adult; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D010698:Phobic Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D012016:Reference Values; D012660:Semantics; D057190:Stroop Test; D055815:Young Adult