Relationship between a family history of malignancy and the incidence of laryngeal carcinoma in the Liaoning province of China.
OBJECTIVE
The purpose of this study was to determine the contribution of family history of malignancy to the incidence of laryngeal squamous cell carcinoma.


METHODS
We performed a retrospective review of classified statistics from the detailed information of cases and matched controls.


METHODS
First Hospital of China Medical University in the Liaoning province of China, between October 2005 and November 2007.


METHODS
A total of 288 previously untreated patients with laryngeal cancer and 296 control subjects with non-malignant diseases were analysed by use of a hospital-based case-control study.


METHODS
Incidence rates and family history of malignancy.


RESULTS
Single-factor logistic regression analysis indicated that the odds ratio value of a family history of malignancy was 2.0 (95% confidence interval: 1.3-3.2). Multiple logistic regression analysis confirmed this result, with an odds ratio value of 2.3 (95% confidence interval: 1.2-4.5). There was significant association between a family history of malignancy and the development of laryngeal squamous cell carcinoma.


CONCLUSIONS
A family history of malignancy plays an important role in and is an independent risk factor for the incidence of laryngeal carcinoma.
Department of Otorhinolaryngology, First Hospital, China Medical University, Shenyang, China.
X-Y
XY
Li
X
X
Guo
S
S
Feng
X-T
XT
Li
H-Q
HQ
Wei
H-A
HA
Yang
Z
Z
Ren
X-J
XJ
Jiang
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology / Q000208:ethnology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D005828:Genetics, Population; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D008113:Liver Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D008175:Lung Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology / Q000208:ethnology; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics