Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau.
We report the possible transmission of drug-resistant human immunodeficiency virus type 2. A 66-year-old woman from rural Guinea Bissau who had no obvious antiretroviral exposure was found to harbor a variant with the multidrug-resistance mutation Q151M. Finding this mutation among a drug-naive population presents an important public health issue that needs to be addressed for treatment to be effective.
Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, The Gambia. sjallow@mrc.gm
Sabelle
S
Jallow
Tim
T
Vincent
Aleksandra
A
Leligdowicz
Thushan
T
De Silva
Carla
C
Van Tienen
Abraham
A
Alabi
Ramu
R
Sarge-Njie
Peter
P
Aaby
Tumani
T
Corrah
Hilton
H
Whittle
Assan
A
Jaye
Guido
G
Vanham
Sarah
S
Rowland-Jones
Wouter
W
Janssens
D000368:Aged; D019943:Amino Acid Substitution / Q000235:genetics; D019380:Anti-HIV Agents / Q000627:therapeutic use; D024921:Drug Resistance, Multiple, Viral; D005260:Female; D006169:Guinea-Bissau; D015658:HIV Infections / Q000635:transmission / Q000821:virology*; D015498:HIV-2 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D017422:Sequence Analysis, DNA
D019380:Anti-HIV Agents