Irrigation with thrombin solution reduces recurrence of chronic subdural hematoma in high-risk patients: preliminary report.
Abstract Chronic subdural hematoma (CSH) is a disease frequently seen in the neurosurgical department. CSH also has a high rate of recurrence. Our hypothesis is that thrombin solution irrigation reduces recurrence in high-risk CSH patients. We define high risk as follows: use of anti-platelets, use of anticoagulants, recurrent CSH, renal failure, liver cirrhosis, and hematological disease. From January 1, 1998, to March 31, 2008, we compared a saline solution irrigation group (43 patients) and a thrombin solution (100 unit/ml) irrigation group (36 patients) prospectively and randomly. Surgical procedures were the same: one burr hole craniostomy, drainage of hematoma, irrigation of cavity, frontal insertion of silicon tube, replacement of air with solution, and removal of tube at 24 h after surgery. We define recurrence as an additional drainage operation due to neurological deficit within six months of surgery. Recurrences of CSH arose in two patients (5.5%) with thrombin irrigation and in 11 patients (25.6%) with saline irrigation (p < 0.05). Saline irrigation patients with anti-platelet medication experienced recurrence in five of 19 patients, although no thrombin-irrigated side recurred with the same drug. No complication occurred in relation to thrombin irrigation. Irrigation of CSH with thrombin solution is an effective treatment option for high-risk cases of CSH without complication.
Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki Aomori, Japan. shimab@cc.hirosaki-u.ac.jp
Norihito
N
Shimamura
Yukari
Y
Ogasawara
Masato
M
Naraoka
Hiroki
H
Ohnkuma
D000368:Aged; D005260:Female; D020200:Hematoma, Subdural, Chronic / Q000188:drug therapy* / Q000601:surgery*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012307:Risk Factors; D055502:Secondary Prevention; D007507:Therapeutic Irrigation; D013917:Thrombin / Q000627:therapeutic use*
D006490:Hemostatics; D013917:Thrombin