Synthesis of polysubstituted pyrroles from sulfinimines (N-sulfinyl imines).
Polysubstituted 2-carboxylate and 2-phosphonate pyrroles are prepared by aromatization of the corresponding 3-oxo 2-carboxylate and 2-phosphonate NH-pyrrolidines using air. Reaction of electrophiles with 3-oxo pyrrolidine dianions readily introduces substituents, regioselectively at C-4 in these pyrrolidines.
Department of Chemistry, Temple University, Philadelphia, PA 19122.
Franklin A
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Davis
Kerisha A
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Bowen
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Xu
Venkata
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Velvadapu