The effects of obesity and HER-2 polymorphisms as risk factors for endometrial cancer in Korean women.
OBJECTIVE
To evaluate the relationship between single nucleotide polymorphisms (SNPs) in the HER-2 gene, body mass index (BMI) and the risk of endometrial cancer.


METHODS
Case-control study.


METHODS
Medical centres in Korea.


METHODS
DNA samples and medical histories were obtained from 125 endometrial cancer cases and 302 controls.


METHODS
The genotypes evaluated in HER-2 at positions -423, -655, -776, -857, -1170, -1177, -1253 of the coding region and two SNPs located in an intron by SNP-IT assay using SNPstream Ultra-high throughput system.


METHODS
Odd ratio for endometrial cancer associated with HER-2 polymorphisms and BMI.


RESULTS
Cases had a significantly higher BMI than controls and the obese subjects had a 2.65-fold increased risk for endometrial cancer. However, HER-2 polymorphism was not associated significantly with the risk of endometrial cancer. Subjects with BMI > or = 25 kg/m2 who carried rs1801200 AA, rs1801200 GA/GG, rs1810132 CT/CC, rs2517951 CT/TT and rs1058808 CG/GG genotype had significantly increased risk of endometrial cancer than subjects with a normal BMI (P for linear trend <0.05). However, the risk in the subjects with the variant allele for HER-2 genotypes did not differ significantly compared to those with homozygous wild-type allele within specific BMI subgroups.


CONCLUSIONS
Endometrial cancer risk increased significantly in proportion to BMI. However, HER-2 polymorphism did not affect significantly on the risk of endometrial cancer.
Department of Obstetrics and Gynecology, East-West Neo Medical Center, Kyung Hee University, Seoul, Korea.
S-Y
SY
Tong
S-Y
SY
Ha
K-D
KD
Ki
J-M
JM
Lee
S-K
SK
Lee
K-B
KB
Lee
M-K
MK
Kim
C-H
CH
Cho
S-Y
SY
Kwon
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D018734:Genes, erbB-2 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors