Nicotinic acetylcholine receptors at atomic resolution.
While the structures of several G protein coupled receptors (GPCRs) have been solved by X-ray crystallography, the high-resolution structure of first ligand-gated ion channels (LGICs) has been available only recently. The ultrastructure of the prototypic LGIC nAChR is deduced from electron microscopy in combination with crystal structures of model proteins. From this analysis, agonist and antagonist binding sites and hints at the mechanism of channel gating become visible.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Victor
V
Tsetlin
Ferdinand
F
Hucho
D000818:Animals; D001665:Binding Sites; D002352:Carrier Proteins / Q000378:metabolism; D015640:Ion Channel Gating / Q000187:drug effects; D008024:Ligands; D008854:Microscopy, Electron; D018722:Nicotinic Agonists / Q000378:metabolism*; D018733:Nicotinic Antagonists / Q000378:metabolism*; D011485:Protein Binding; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*
C428944:AChBP protein, Lymnaea; D002352:Carrier Proteins; D008024:Ligands; D018722:Nicotinic Agonists; D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic