title: Effectiveness and economic analysis of the whole cell/recombinant B subunit (WC/rbs) inactivated oral cholera vaccine in the prevention of traveller's diarrhoea.
abstract: BACKGROUND
  Nowadays there is a debate about the indication of the oral whole-cell/recombinant B-subunit cholera vaccine (WC/rBS) in traveller's diarrhoea. However, a cost-benefit analysis based on real data has not been published.
  
  
  METHODS
  A cost-effectiveness and cost-benefit study of the oral cholera vaccine (WC/rBS), Dukoral for the prevention of traveller's diarrhoea (TD) was performed in subjects travelling to cholera risk areas. The effectiveness of WC/rBS vaccine in the prevention of TD was analyzed in 362 travellers attending two International Vaccination Centres in Spain between May and September 2005.
  
  
  RESULTS
  The overall vaccine efficacy against TD was 42,6%. Direct healthcare-related costs as well as indirect costs (lost vacation days) subsequent to the disease were considered. Preventive vaccination against TD resulted in a mean saving of 79.26 euro per traveller.
  
  
  CONCLUSIONS
  According to the cost-benefit analysis performed, the recommendation for WC/rBS vaccination in subjects travelling to zones at risk of TD is beneficial for the traveller, regardless of trip duration and visited continent.
authors.affiliation: International Vaccination Centre of Malaga, Ministry of Health, Subdelegation in Malaga, Paseo Marítimo Pablo Ruiz, Picasso 43, 29017 Málaga, Spain. rosamaria.lopez@map.es
authors.forename: Rosa
authors.initials: R
authors.lastname: López-Gigosos
authors.forename: Pedro
authors.initials: P
authors.lastname: Garcia-Fortea
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Calvo
authors.forename: Emilia
authors.initials: E
authors.lastname: Reina
authors.forename: Rosa
authors.initials: R
authors.lastname: Diez-Diaz
authors.forename: Elena
authors.initials: E
authors.lastname: Plaza
mesh_terms: D000284:Administration, Oral; D002771:Cholera / Q000191:economics / Q000517:prevention & control*; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000191:economics*; D015331:Cohort Studies; D003362:Cost-Benefit Analysis; D003967:Diarrhea / Q000191:economics / Q000382:microbiology / Q000517:prevention & control*; D017048:Health Care Costs; D006801:Humans; D018803:Models, Economic; D012189:Retrospective Studies; D013030:Spain; D014195:Travel; D016896:Treatment Outcome
chemical_list: D022121:Cholera Vaccines