title: Differential roles of OxyR-controlled antioxidant enzymes alkyl hydroperoxide reductase (AhpCF) and catalase (KatB) in the protection of Pseudomonas aeruginosa against hydrogen peroxide in biofilm vs. planktonic culture.
abstract: The role of the Pseudomonas aeruginosa OxyR-controlled antioxidants alkyl hydroperoxide reductase CF (AhpCF) and catalase B (KatB) was evaluated in biofilm vs. planktonic culture upon exposure to hydrogen peroxide. AhpCF was found to be critical for survival of biofilm bacteria while KatB was more important for survival of planktonic free-swimming organisms.
authors.affiliation: Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Warunya
authors.initials: W
authors.lastname: Panmanee
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Hassett
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D002374:Catalase / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D003470:Culture Media; D015964:Gene Expression Regulation, Bacterial; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D054464:Peroxiredoxins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D010933:Plankton / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D015534:Trans-Activators / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D001426:Bacterial Proteins; D003470:Culture Media; C524857:OxyR protein, Pseudomonas aeruginosa; D015534:Trans-Activators; D006861:Hydrogen Peroxide; D054464:Peroxiredoxins; D002374:Catalase