Spleen modulation of cytoadherence properties of Plasmodium falciparum.
Cytoadherence to CD36 and ICAM-1 and var gene expression of P. falciparum parasites from a splenectomized patient were studied. These parasites lacked cytoadherence and showed expression of a non-coding cDNA sequence. Hence the spleen's modulation of parasite cytoadherence by mechanisms that affect the parasite's surface antigen expression is suggested.
Munasinghe
Anjanie
A
Malaria Research Unit, Department of Parasitology, Faculty of Medicine, University of Colombo, Sri Lanka.
Ileperuma
Manjula
M
Premawansa
Gayani
G
Handunnetti
Shiroma
S
Premawansa
Sunil
S
D000818:Animals; D018955:CD36 Antigens / Q000378:metabolism; D016466:CHO Cells; D002448:Cell Adhesion / Q000502:physiology*; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D013154:Spleen / Q000378:metabolism / Q000469:parasitology*
D018955:CD36 Antigens; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum; D018799:Intercellular Adhesion Molecule-1