A comprehensive guide to the ROMK potassium channel: form and function in health and disease.
The discovery of the renal outer medullary K+ channel (ROMK, K(ir)1.1), the founding member of the inward-rectifying K+ channel (K(ir)) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.
Welling
Paul A
PA
Dept. of Physiology, Univ. of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA. pwelling@umaryland.edu
Ho
Kevin
K
D000818:Animals; D001477:Bartter Syndrome / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
C086989:KCNJ1 protein, human; D024661:Potassium Channels, Inwardly Rectifying; D011188:Potassium