title: Endocytic regulation of Notch signaling.
abstract: Endocytosis and endosomal trafficking have emerged as important cell biological steps in the Notch developmental signaling pathway. Ligand endocytosis helps generate the physical forces needed to dissociate and activate the receptor, and activated receptors enter endosomes to signal productively. Endosomal trafficking is also responsible for downregulating Notch receptors that have not been activated by ligand. Recent studies have provided new insights into these Notch trafficking steps, and have uncovered additional endosomal mechanisms that contribute to asymmetric Notch activation and ligand-independent Notch signaling.
authors.affiliation: Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 830 Bluemle Life Sciences Building, 233 South 10th Street, Philadelphia, PA 19107, USA. mark.fortini@jefferson.edu
authors.forename: Mark E
authors.initials: ME
authors.lastname: Fortini
authors.forename: David
authors.initials: D
authors.lastname: Bilder
mesh_terms: D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism; D008954:Models, Biological; D021381:Protein Transport / Q000502:physiology; D051880:Receptors, Notch / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D051880:Receptors, Notch