title: Case report: pulp revascularization of a necrotic, infected, immature, permanent tooth.
abstract: The purpose of this report is to present the case of a patient wherein revascularization of the necrotic infected pulp space of an immature permanent maxillary central incisor tooth was induced in vivo by stimulation of a blood clot from the periapical tissues into the canal space. This was achieved after disinfecting the canal space with a topical antibiotic paste followed by inducing a blood clot scaffold from the periapical tissues. This treatment approach offers great potential to avoid the need for traditional apexification with calcium hydroxide or the need to achieve an artificial apical barrier with mineral trioxide aggregate. Furthermore, this treatment approach can help rescue infected immature teeth by physiologically strengthening the root walls.
authors.affiliation: University of Saskatchewan, College of Dentistry, Saskatoon, Saskatchewan, Canada. blaynethibodeau@gmail.com
authors.forename: Blayne
authors.initials: B
authors.lastname: Thibodeau
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001777:Blood Coagulation / Q000502:physiology; D017610:Calcium Compounds / Q000627:therapeutic use; D002433:Cefaclor / Q000008:administration & dosage; D002648:Child; D002939:Ciprofloxacin / Q000008:administration & dosage; D003786:Dental Pulp Cavity / Q000473:pathology; D003790:Dental Pulp Necrosis / Q000628:therapy*; D004338:Drug Combinations; D005500:Follow-Up Studies; D006801:Humans; D007180:Incisor / Q000098:blood supply / Q000473:pathology*; D008297:Male; D008437:Maxilla; D008795:Metronidazole / Q000008:administration & dosage; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010087:Oxides / Q000627:therapeutic use; D010482:Periapical Abscess / Q000628:therapy*; D010486:Periapical Tissue / Q000473:pathology; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D012388:Root Canal Irrigants / Q000627:therapeutic use; D012390:Root Canal Therapy / Q000379:methods; D017640:Silicates / Q000627:therapeutic use; D012973:Sodium Hypochlorite / Q000627:therapeutic use; D019227:Tooth Apex / Q000473:pathology
chemical_list: D017607:Aluminum Compounds; D000890:Anti-Infective Agents; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D012388:Root Canal Irrigants; D017640:Silicates; C086631:mineral trioxide aggregate; D008795:Metronidazole; D002939:Ciprofloxacin; D002433:Cefaclor; D012973:Sodium Hypochlorite