Absolute stereostructures of chaetomugilins G and H produced by a marine-fish-derived Chaetomium species.
Chaetomugilins G and H were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish, Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and chemical transformation. In addition, the absolute configuration of chaetoviridin C was established by derivatization from chaetomugilin A. These compounds exhibited a growth inhibitory activity against cultured P388, HL-60, L1210 and KB cells.
Yamada
Takeshi
T
Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Nasahara 4-20-1, Takatsuki, Osaka, Japan. yamada@gly.oups.ac.jp
Yasuhide
Muroga
M
Shigeta
Hirohumi
H
Numata
Atsushi
A
Tanaka
Reiko
R
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D045744:Cell Line, Tumor; D002597:Chaetomium / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D005399:Fishes / Q000382:microbiology*; D005663:Furans / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011753:Pyrones / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000903:Antibiotics, Antineoplastic; D005663:Furans; D011753:Pyrones; C544341:chaetomugilin G; C544342:chaetomugilin H