title: Cytomegalovirus-associated protein-losing enteropathy resulting from lymphangiectasia in an immunocompetent child.
abstract: An immunocompetent 8-year-old boy with cytomegalovirus (CMV)-associated transient protein-losing enteropathy (PLE) is described. Colonoscopic examination revealed lymphoid hyperplasia of the terminal ileum. Histological examination of the biopsied specimens showed marked dilation of the lymphatic vessels. Primary CMV infection was demonstrated by serological test and polymerase chain reaction. The child had complete resolution of the disease without antiviral treatment. The present case suggests the etiologic role of CMV infection in PLE resulting from intestinal lymphangiectasia in childhood.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. hoshina@pediatr.med.kyushu-u.ac.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hoshina
authors.forename: Koichi
authors.initials: K
authors.lastname: Kusuhara
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Saito
authors.forename: Takuya
authors.initials: T
authors.lastname: Hara
authors.forename: Shuji
authors.initials: S
authors.lastname: Mtsuura
authors.forename: Takashi
authors.initials: T
authors.lastname: Yano
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Aoki
authors.forename: Toshiro
authors.initials: T
authors.lastname: Hara
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis* / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D004487:Edema; D006801:Humans; D007082:Ileum / Q000473:pathology / Q000821:virology; D007121:Immunocompetence; D007413:Intestinal Mucosa / Q000473:pathology / Q000821:virology; D008201:Lymphangiectasis, Intestinal / Q000150:complications / Q000175:diagnosis*; D008297:Male; D016133:Polymerase Chain Reaction; D011504:Protein-Losing Enteropathies / Q000175:diagnosis* / Q000209:etiology / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral