[Managing adult patients with acute community-acquired meningitis presumed of bacterial origin].
Early clinical data must lead to suspect bacterial meningitis if fever, the most frequent sign, is present and if it is associated with more or less constant neurological and meningeal signs (consciousness impairment, headache, neck stiffness, focal neurological deficit, seizure, etc.). A skin rash is frequent in case of meningococcal meningitis whereas cranial nerve palsy is more in favor of tuberculous or Listeria meningitis. Presence of otitis, sinusitis, pneumonia, or a recent head trauma strongly suggests a pneumococcal involvement. Tuberculous meningitis is generally characterized by a slow evolution of meningeal signs together with aspecific signs. The main prognostic factors are consciousness impairment, circulatory instability, focal neurological signs, and advanced age. Morbidity and mortality are increased in case of pneumococcal compared to meningococcal meningitis. Cranial tomodensitometry gives further information about intracranial complications of meningitis. In some cases, particularly if focal neurological or intracranial hypertension signs are present, it must be performed before a lumbar puncture. The risk factors of meningitis must be investigated and treated if possible according to the bacterium. The management of patient after hospital discharge depends on evolution after treatment. The presence of neurological sequels imposes a specialized ambulatory follow-up. Neuropsychological sequels (cognitive dysfunction, memory impairment) can also persist for years even in absence of other neurological disorders.
Forestier
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Service de médecine interne et maladies infectieuses, centre hospitalier de Chambéry, BP 1125, 73011 Chambery cedex, France. emmanuel.forestier@ch-chambery.fr
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D003072:Cognition Disorders / Q000209:etiology; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D003937:Diagnosis, Differential; D005076:Exanthema / Q000209:etiology / Q000382:microbiology; D006801:Humans; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D008590:Meningoencephalitis / Q000000981:diagnostic imaging / Q000628:therapy; D013129:Spinal Puncture; D014057:Tomography, X-Ray Computed