title: Adipose tissue at the crossroads in the development of the metabolic syndrome, inflammation and atherosclerosis.
abstract: The authors analyze insulin resistance, the metabolic syndrome and endothelial dysfunction as consequence of a common antecedent, a low grade inflammation, indicating that in obesity there is a chronically activated inflammatory state of the adipose tissue. Furthermore, the inflammatory signaling is discussed according to the adipose tissue depot, visceral or subcutaneous.
authors.affiliation: Serviço de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Arnaldo 455, São Paulo, SP, Brazil. bernarwaj@globo.com
authors.forename: Bernardo Léo
authors.initials: BL
authors.lastname: Wajchenberg
authors.forename: Marcia
authors.initials: M
authors.lastname: Nery
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Cunha
authors.forename: Maria Elizabeth Rossi da
authors.initials: ME
authors.lastname: Silva
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D050152:Intra-Abdominal Fat / Q000378:metabolism; D024821:Metabolic Syndrome / Q000209:etiology / Q000503:physiopathology*; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D015434:Panniculitis / Q000378:metabolism / Q000503:physiopathology*; D050151:Subcutaneous Fat / Q000378:metabolism
chemical_list: D054392:Adipokines; D018836:Inflammation Mediators