Diabetes mellitus and drug-induced Parkinsonism: a case-control study.
To investigate if diabetes is more common in drug-induced parkinsonism patients. We performed a hospital-based retrospective case-control study on 44 drug-induced parkinsonism (DIP) patients, 177 Parkinson disease patients, and 176 acute stroke patients matched for age and sex who were seen over the same period at the same hospital. The frequency of diabetes, age-at onset and sex were compared between DIP and IPD or acute stroke. Multivariate analysis showed that patients with diabetes are more frequent in DIP compared with IPD (p<0.001, adjusted OR 5.48; 95% CI, 2.52-11.94). The frequency of diabetes in DIP was comparable to that in acute stroke patients (p=0.16, adjusted OR 0.62; 95% CI, 0.32-1.21). These data suggest that diabetes may be a risk factor for DIP. Drugs with dopamine receptor blocking potency should be avoided in elderly with diabetes.
Ma
Hyeo-Il
HI
Department of Neurology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.
Kim
Jin-Hyuck
JH
Chu
Min-Kyung
MK
Oh
Mi-Sun
MS
Yu
Kyung-Ho
KH
Kim
Jooyong
J
Hahm
Woong
W
Kim
Yun Joong
YJ
Lee
Byung-Chul
BC
D017668:Age of Onset; D000368:Aged; D000075202:Contraindications; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D003929:Diabetic Neuropathies / Q000150:complications / Q000188:drug therapy; D004198:Disease Susceptibility; D018492:Dopamine Antagonists / Q000009:adverse effects*; D065127:Dopamine D2 Receptor Antagonists; D005260:Female; D018589:Gastroparesis / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D016037:Single-Blind Method; D020521:Stroke / Q000453:epidemiology; D013469:Sulpiride / Q000009:adverse effects / Q000031:analogs & derivatives
D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D013469:Sulpiride; C078143:levosulpiride