title: Glyoxalase I Glu111Ala polymorphism in patients with breast cancer.
abstract: Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluble RAGE or by reducing AGE-precursors via glyoxalase I. Glu111Ala polymorphism of glyoxalase I gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls. Higher frequency of the mutated C allele was found in patients with negative estrogen receptors and in patients in clinical stage III compared to controls (P< 0.05). The presence of the C allele could represent a negative prognostic factor; however, further studies are needed to confirm this hypothesis.
authors.affiliation: Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Germanová
authors.forename: Anna
authors.initials: A
authors.lastname: Germanová
authors.forename: Petra
authors.initials: P
authors.lastname: Tesarová
authors.forename: Marie
authors.initials: M
authors.lastname: Jáchymová
authors.forename: Karel
authors.initials: K
authors.lastname: Zvára
authors.forename: Tomás
authors.initials: T
authors.lastname: Zima
authors.forename: Marta
authors.initials: M
authors.lastname: Kalousová
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D005787:Gene Frequency; D005838:Genotype; D017127:Glycation End Products, Advanced / Q000097:blood; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D000067759:Receptor for Advanced Glycation End Products; D011960:Receptors, Estrogen / Q000032:analysis; D011971:Receptors, Immunologic / Q000097:blood
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011960:Receptors, Estrogen; D011971:Receptors, Immunologic; D007791:Lactoylglutathione Lyase