Recognizing macrophage activation and host defense.
G.B. Shaw's entreaty, "Stimulate the phagocytes," found its perfect interlocutor in Carl Nathan. Nearly 40 years ago, Nathan discovered macrophages were activated via soluble mediators released from T-lymphocytes-later identified as interferon-gamma (IFN-gamma)-for killing microbial pathogens. This year's Robert Koch Prize celebrates a lasting legacy for innate immunity.
MacMicking
John D
JD
Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA. john.macmicking@yale.edu
D000486:Allergy and Immunology / Q000266:history*; D000818:Animals; D001363:Awards and Prizes; D049673:History, 20th Century; D049674:History, 21st Century; D054884:Host-Pathogen Interactions; D006801:Humans; D007109:Immunity; D007371:Interferon-gamma / Q000276:immunology*; D008262:Macrophage Activation; D014481:United States
D007371:Interferon-gamma