Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial.
A series of (5S) N-(3-{3-fluoro-4-[4-(3-aryl-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide(6a-o) were synthesized and their in vitro antibacterial activity against various resistant Gram-positive and Gram-negative bacteria were evaluated. Most of the synthesized compounds showed 2 to 10 fold lower MIC values compared to linezolid against Staphylococcus aureusATCC 25923, ATCC 70069, ATCC 29213,Bacillus cereusMTCC 430,Enterococcus faecalisMTCC439,Klebsiella pneumoniaeATCC 27736, and Streptococcus pyogens.
Varshney
Vandana
V
Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
Mishra
Nripendra N
NN
Shukla
Praveen K
PK
Sahu
Devi P
DP
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D023303:Oxazolidinones