NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats.
The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels, however, remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.
Park
Sung Hoon
SH
Laboratory Animal Medicine, and KRF Priority Zoonotic Disease Research Institute, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
Dutta
Noton Kumar
NK
Baek
Min Won
MW
Kim
Dong Jae
DJ
Na
Yi Rang
YR
Seok
Seung Hyeok
SH
Lee
Byoung Hee
BH
Cho
Ji Eun
JE
Cho
Geon Sik
GS
Park
Jae Hak
JH
D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000096:biosynthesis; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D048271:Chitosan / Q000008:administration & dosage*; D002712:Chlorides / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000652:urine; D006321:Heart / Q000502:physiology; D006651:Histocytochemistry; D006973:Hypertension / Q000517:prevention & control*; D007668:Kidney / Q000502:physiology; D008297:Male; D011188:Potassium / Q000097:blood / Q000652:urine; D011189:Potassium Chloride / Q000008:administration & dosage; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D012964:Sodium / Q000097:blood / Q000652:urine; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*; D013599:Systole / Q000187:drug effects / Q000502:physiology
D002712:Chlorides; D017673:Sodium Chloride, Dietary; D000804:Angiotensin II; D011189:Potassium Chloride; D048271:Chitosan; D000803:Angiotensin I; D012964:Sodium; D003404:Creatinine; D011188:Potassium