Does cardiac morphology predict plasma brain natriuretic Peptide levels in adolescent athletes?
OBJECTIVE
The purpose of this study was to establish the relationship of plasma levels of brain natriuretic peptide (BNP) to physiologic parameters and cardiac morphologic characteristics in a population of young athletes. Our hypothesis is that physiologic and cardiac morphologic characteristics do not predict BNP levels in adolescent athletes.


METHODS
Observational study.


METHODS
Outpatient hospital.


METHODS
Thirty healthy male adolescent high school football players (16.0 +/- 1.1 years).


METHODS
Physical exam, electrocardiography, plasma BNP measurement by rapid fluorescent immunoassay, and limited echocardiography.


METHODS
Null hypothesis-physiologic parameters and cardiac morphology do not predict plasma BNP levels in healthy adolescent football players. Significance level set at P < 0.05.


RESULTS
Plasma BNP for this population was 11.9 +/- 10.2 pg/mL. There was no correlation between BNP and mean arterial pressure (r = -0.09, P = 0.64), body mass index (r = 0.11, P = 0.57), interventricular septal thickness (r = -0.15, P = 0.44), left ventricular (LV) wall thickness (r = 0.00, P = 0.99), relative wall thickness (r = -0.04, P = 0.84), LV mass (r = 0.05, P = 0.79), or LV mass index (r = 0.11, P = 0.55).


CONCLUSIONS
Plasma BNP levels in healthy adolescent athletes have no correlation to body mass index or LV mass, even when corrected for body surface area.
Nilsson
Kurt J
KJ
Intermountain Orthopaedics, Boise, Idaho 83702, USA. mdrezman@yahoo.com
Womack
Michael S
MS
Pfeiffer
Ronald P
RP
Harris
Chad
C
DeBeliso
Mark
M
D000222:Adaptation, Physiological / Q000502:physiology; D000293:Adolescent; D001794:Blood Pressure; D015992:Body Mass Index; D005538:Football / Q000502:physiology; D006346:Heart Septum / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000378:metabolism*; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests; D013312:Stress, Physiological / Q000502:physiology; D014463:Ultrasonography
D020097:Natriuretic Peptide, Brain