title: Gracillosides A-F, six new 8,14-seco-pregnane glycosides from Adelostemma gracillimum.
abstract: Six new 8,14-seco-pregnane glycosides, gracillosides A-F (1-6), were isolated from the roots of Adelostemma gracillimum (Asclepiadaceae). All of them had the same aglycone as gracigenin with a rare 8,14-seco-pregnane type skeleton in nature and possessed an oligosaccharide chain consisting of four to six sugar units at C-3 of the aglycone. Their structures were determined on the basis of detailed spectroscopic analysis and chemical evidence.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
authors.forename: Zhu-Lin
authors.initials: ZL
authors.lastname: Gao
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Xin
authors.initials: X
authors.lastname: Fang
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
authors.forename: Qian-Lan
authors.initials: QL
authors.lastname: Zhou
authors.forename: Quan-Zhang
authors.initials: QZ
authors.lastname: Mu
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D029062:Apocynaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D006027:Glycosides; D011278:Pregnanes