[Involvement of presynaptic 5-HT1A receptors in immunomodulation under conditions of psychoemotional state].
The development of the immune reaction after the activation or blockade of presynaptic 5-HT1A receptors, respectively, with a selective agonist or antagonist depends on specific behavioral patterns. Agonist of 5-HT1A receptors 8-OH-DPAT (0.1 mg/kg 15 min prior to immunization) did not change the number of IgM plaque-forming cells in the spleen of aggressive mice at the peak of the immune response (the 4-th day after immunization) but increased their number in submissive animals, in which the baseline immune response was lower than in aggressive animals. Administration of WAY-100635 (0.1 mg/kg 30 min prior to immunization) resulted in a decrease in the immune reaction in aggressive mice and led to its increase in submissive animals. It is suggested that the immunomodulatory effects of drugs affecting the activity of presynaptic 5-HT1A receptors are related to changes in the functional state of these receptors and the interaction between serotonin- and dopaminergic systems.
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D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000374:Aggression / Q000502:physiology*; D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology*; D017660:Autoreceptors / Q000819:agonists / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology*; D004291:Dominance-Subordination; D007075:Immunoglobulin M / Q000276:immunology; D007155:Immunologic Factors / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015213:Neuroimmunomodulation; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D044282:Receptor, Serotonin, 5-HT1A / Q000502:physiology*; D017661:Receptors, Presynaptic / Q000819:agonists / Q000502:physiology*; D058825:Serotonin 5-HT1 Receptor Agonists; D058829:Serotonin 5-HT1 Receptor Antagonists; D013154:Spleen / Q000166:cytology / Q000276:immunology
D017660:Autoreceptors; D007075:Immunoglobulin M; D007155:Immunologic Factors; D010879:Piperazines; D011725:Pyridines; D017661:Receptors, Presynaptic; D058825:Serotonin 5-HT1 Receptor Agonists; D058829:Serotonin 5-HT1 Receptor Antagonists; D044282:Receptor, Serotonin, 5-HT1A; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin