Context dependent effects of ventral tegmental area inactivation on spatial working memory.
Rats were tested on a hippocampus dependent win-shift working memory task in familiar or novel environments after receiving bilateral ventral tegmental area infusions of baclofen. Baclofen infusion disrupted working memory performance in both familiar and novel environments. In addition, baclofen infusion selectively disrupted short-term working memory in the novel environment. This experiment confirms selective ventral tegmental area support of accurate performance during a context dependent spatial navigation task.
Martig
Adria K
AK
Psychology Department, Box 351525, University of Washington, Seattle, WA 98195-1525, United States.
Jones
Graham L
GL
Smith
Kelsey E
KE
Mizumori
Sheri J Y
SJ
D000704:Analysis of Variance; D000818:Animals; D001418:Baclofen / Q000633:toxicity; D006624:Hippocampus / Q000502:physiology; D018782:Maze Learning; D008570:Memory, Short-Term / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D013037:Spatial Behavior; D017557:Ventral Tegmental Area / Q000503:physiopathology*
D001418:Baclofen