[Stress-induced changes in functional activity of the neuro-endocrine system: modulatory action of derinat].
Changes in functional activity of HPA and HPG axes under stress influences of different intensity, and possible ways for their correction by native DNA preparation: derinat, possessing immune modulator effects, were studied. It was shown that the vector of changes in hormone's reactions of both axes did not depend on the intensity of stress influences: different models of stress increased corticosterone level and decreased testosterone level in rats' blood. Intraperitoneal injection of 10 and 50 mg/kg BW doses of Derinat to rats enhanced HPA and HPG axes activity, reversed stress-induced decrease of testosterone concentration in blood, that may indicate a stress-protective effect of derinat. Injection of derinat caused normalizing of stress-induced changes in immunomodulatory cytokines production within Lymphocyte Activating Factors, which regulate not only the immune system functions but also the functions of HPA and HPG axes.
Fomicheva
E E
EE
Filatenkova
T A
TA
Shanin
S N
SN
Rybakina
E G
EG
D000818:Animals; D003345:Corticosterone / Q000097:blood; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D004247:DNA / Q000008:administration & dosage*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000503:physiopathology; D007155:Immunologic Factors / Q000008:administration & dosage*; D007375:Interleukin-1 / Q000096:biosynthesis / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D013739:Testosterone / Q000097:blood
D016207:Cytokines; C541364:Derinat; D007155:Immunologic Factors; D007375:Interleukin-1; D013739:Testosterone; D004247:DNA; D003345:Corticosterone