title: Levetiracetam-induced platelet dysfunction.
abstract: Levetiracetam is an antiepileptic drug widely prescribed. We report here for the first time, an alteration of platelet function attributable to this drug. This effect has never been reported before. The responsibility of levetiracetam seems to be probable: restoration of platelet functionality was observed after withholding this treatment and this effect has been described for a structurally related molecule, piracetam.
authors.affiliation: Hématologie Biologique, CHU Nancy, allée du Morvan, Vandoeuvre-les-Nancy, France. m.toussaint-hacquard@chu-nancy.fr
authors.forename: Marie
authors.initials: M
authors.lastname: Hacquard
authors.forename: Sébastien
authors.initials: S
authors.lastname: Richard
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Lacour
authors.forename: Thomas
authors.initials: T
authors.lastname: Lecompte
authors.forename: Hervé
authors.initials: H
authors.lastname: Vespignani
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D001791:Blood Platelet Disorders / Q000139:chemically induced* / Q000473:pathology; D000077144:Clopidogrel; D006801:Humans; D000077287:Levetiracetam; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D010975:Platelet Aggregation Inhibitors; D000077287:Levetiracetam; D000077144:Clopidogrel; D013988:Ticlopidine; D010889:Piracetam