Immobilization and chiral recognition of 3,5-dimethylphenylcarbamates of cellulose and amylose bearing 4-(trimethoxysilyl)phenylcarbamate groups.
A small amount of 4-(trimethoxysilyl)phenyl groups was randomly introduced onto the 3,5-dimethylphenylcarbamates of cellulose and amylose by a one-pot method. The obtained derivatives were then effectively immobilized onto silica gel as chiral packing materials (CPMs) for high-performance liquid chromatography through intermolecular polycondensation of the trimethoxysilyl groups. The effects of the amount of 4-(trimethoxysilyl)phenyl groups on immobilization and enantioseparation were investigated. Also, the solvent durability of the immobilized-type CPMs was examined with the eluents containing chloroform and tetrahydrofuran. When these eluents were used, the chiral recognition abilities of the CPMs for most of the tested racemates were improved to some extent depending on the compounds.
Tang
Shouwan
S
EcoTopia Science Institute, Nagoya University, Furo-Cho, Chikusa-Ku, Nagoya, Japan.
Ikai
Tomoyuki
T
Tsuji
Masashi
M
Okamoto
Yoshio
Y