A glance over the cannabinoid machinery to design new anti-angiogenic compounds.
Aim of the present review is to summarize the different evidences regarding the ability of cannabinoids to control new vessels formation, and in this way, to suggest new possible molecular targets for the development of drugs which may be helpful in the management of different pathological condition associated to angiogenesis.
De Filippis
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Endocannabinoid Research Group, Department of Experimental Pharmacology, Faculty of Pharmacy University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. daniledef@gmail.com
Iuvone
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D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology; D063385:Cannabinoid Receptor Modulators / Q000096:biosynthesis / Q000378:metabolism; D002186:Cannabinoids / Q000096:biosynthesis / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D009389:Neovascularization, Pathologic / Q000188:drug therapy*
D020533:Angiogenesis Inhibitors; D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids