[Efficacy of one combined inhaled drug in the treatment of patients with bronchial asthma depending on the disease duration].
OBJECTIVE
To assess an effect of long-term administration of one combined inhaled drug containing glucocorticosteroids (GCS) and long-acting beta2-agonists (LABA) on patient compliance.


METHODS
The trial included 47 patients (14 males and 33 females, mean age 48.8 +/- 13.2 years) with bronchial asthma (BA) of different severity and duration (from 1 month to 42 years). The patients were divided into two groups by BA duration: 20 patients with newly diagnosed BA and 27 patients with a long history of BA. Cooperation was judged by the questionnaire Index of Cooperation in Bronchial Asthma. Control of BA for the last 4 weeks was determined according to Asthma Control Test.


RESULTS
Patients with BA of new onset have low mean rating of compliance. One combined inhaled drug improved compliance in both groups but the improvement was less in patients with new-onset BA. The ACT-test showed that the above inhaled improve control of BA.


CONCLUSIONS
Therapy with one combined inhaled drug containing GCS and LABA is highly effective in patients with BA of different severity. This promotes higher compliance and, finally, produces better effect.
Ovcharenko
S I
SI
Akulova
M N
MN
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D019819:Budesonide / Q000008:administration & dosage*; D004338:Drug Combinations; D004983:Ethanolamines / Q000008:administration & dosage*; D005260:Female; D000068759:Formoterol Fumarate; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012138:Respiratory Therapy; D011795:Surveys and Questionnaires
D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D004338:Drug Combinations; D004983:Ethanolamines; D005938:Glucocorticoids; D019819:Budesonide; D000068759:Formoterol Fumarate