New development of glycan arrays.
The development of glycan arrays has enabled the high-sensitivity and high-throughput analysis of carbohydrate-protein interactions and contributed to significant advances in glycomics. A number of new array platforms that allow for qualitative and quantitative analysis of mono- and multivalent interactions on surfaces have been developed recently. Glycan arrays are not only a powerful tool for basic research, but also a promising technique for medical diagnosis, and detection of pathogens and cancers. These studies also have led to the design of efficient carbohydrate-based antimicrobial or anticancer vaccines.
Wu
Chung-Yi
CY
The Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan. cyiwu@gate.sinica.edu.tw
Liang
Pi-Hui
PH
Wong
Chi-Huey
CH
D000818:Animals; D000911:Antibodies, Monoclonal / Q000097:blood / Q000276:immunology; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry / Q000276:immunology; D002240:Carbohydrate Sequence; D003141:Communicable Diseases / Q000175:diagnosis*; D054794:Glycomics / Q000295:instrumentation / Q000379:methods / Q000639:trends; D006023:Glycoproteins / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D046228:Microarray Analysis / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000175:diagnosis*; D011134:Polysaccharides / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; C472765:Globo-H; D006023:Glycoproteins; D006025:Glycosaminoglycans; D011134:Polysaccharides