Second-generation histamine H(2)-receptor antagonists with gastric mucosal defensive properties.
Unlike the earlier agents in this class, certain of the newer histamine H(2)-receptor antagonists (so-called second-generation HB(2B)-receptor antagonists) have recently been reported to promote gastric mucosal defenses. We review herein the structure, specificity, and mechanisms of these agents with a special focus on their cytoprotective/gastroprotective actions.
Ichikawa
Takafumi
T
Department of Biochemistry, Kitasato University School of Medicine, 1-15-1, Kitasato, Sagamihara, Kanagawa 228-8555, Japan. t.ichika@kitasato-u.ac.jp
Hotta
Kyoko
K
Ishihara
Kazuhiko
K
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D006635:Histamine H2 Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D011970:Receptors, Histamine H2 / Q000378:metabolism*; D013329:Structure-Activity Relationship
D006635:Histamine H2 Antagonists; D011970:Receptors, Histamine H2