title: Mirena (Levonorgestrel intrauterine system): a successful novel drug delivery option in contraception.
abstract: This manuscript serves as a review of Mirena, the levonorgestrel intrauterine system (LNG IUS) as a very successful drug delivery system. The LNG IUS has a very high contraceptive efficacy rate, and low rates of patient discontinuation. In addition to its contraceptive benefits, most users experience a decrease in menstrual bleeding over the 5 years of use. LNG IUS has also been used for management of menorrhagia, dysmenorrhea, adenomyosis, and endometrial hyperplasia in some cases. The LNG IUS provides long term efficacy, high rates of compliance, rapid return to fertility, and minimal adverse effects during use.
authors.affiliation: Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, 50 North Medical Drive, Suite 2B200, Salt Lake City, Utah 84132, USA. Susan.rose@hsc.utah.edu
authors.forename: Susan
authors.initials: S
authors.lastname: Rose
authors.forename: Angela
authors.initials: A
authors.lastname: Chaudhari
authors.forename: C Matthew
authors.initials: CM
authors.lastname: Peterson
mesh_terms: D000282:Administration, Intravaginal; D003267:Contraception; D003271:Contraceptive Agents, Female / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004334:Drug Administration Schedule; D016503:Drug Delivery Systems; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy; D006801:Humans; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D008599:Menstruation Disturbances / Q000188:drug therapy; D017060:Patient Satisfaction
chemical_list: D003271:Contraceptive Agents, Female; D016912:Levonorgestrel