title: Health related quality of life in recurrent depression: a comparison with a general population sample.
abstract: BACKGROUND
  In the acute phase major depressive disorder (MDD) is a disabling disease. We compared HRQOL in patients with remitted MDD (rMDD) with a community sample and longitudinally assessed the relation between depressive symptoms and HRQOL in recurrently depressed patients.
  
  
  METHODS
  We used 12-month data of patients from the Depression Evaluation Longitudinal Therapy Assessment (DELTA) study. HRQOL was assessed with the Medical Outcome Short Form (SF-36). Remission was determined with the Structured Clinical Interview for DSM-IV and depressive symptoms were assessed with the Beck Depression Inventory. Patients' mean SF-36 scores were compared with those of an age- and sex-matched Dutch reference population. The longitudinal relation between levels of SF-36 and levels of depressive symptomatology was assessed with a repeated measures linear regression analysis using the mixed models module.
  
  
  RESULTS
  In patients with rMDD in the remitted phase, especially in women, both physical and mental HRQOL was lower than in a Dutch population sample. An increase in the level of depressive symptoms corresponded to a decrease in all scales of the SF-36.
  
  
  CONCLUSIONS
  Also in remitted rMDD patients, especially in women, HRQOL is lower than in the general population which emphasizes that also in this phase of recurrent depression HRQOL deserves attention. Furthermore, in patients with rMDD a higher depressive symptom severity level is associated with a lower HRQOL. These findings imply that residual symptoms should be treated aggressively and HRQOL enhancement therapies should be developed.
authors.affiliation: Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. m.c.tendoesschate@amc.uva.nl
authors.forename: Mascha C
authors.initials: MC
authors.lastname: ten Doesschate
authors.forename: Maarten W J
authors.initials: MW
authors.lastname: Koeter
authors.forename: Claudi L H
authors.initials: CL
authors.lastname: Bockting
authors.forename: Aart H
authors.initials: AH
authors.lastname: Schene
mesh_terms: D000208:Acute Disease; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D011159:Population Surveillance / Q000379:methods*; D011788:Quality of Life / Q000523:psychology*; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents