Transient responses of inflammatory cytokines in acute stress.
It has been demonstrated that concentrations of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) are elevated by acute stress. Although several studies confirmed robust changes in IL-6, how acute stress affects other cytokines was less clear. Therefore, the present study simultaneously examined the effects of acute stress on several pro-inflammatory cytokines. Sixteen male participants were given the Trier Social Stress Test (TSST). Blood samples were collected at baseline, immediately after, and 30, 60, and 90min after the TSST. IL-1beta significantly increased immediately after the TSST and returned to the baseline level after 30min. Additionally, this elevation of IL-1beta was correlated with the perceived intensity of stress. These results showed that the concentration of IL-1beta is rapidly regulated, and that elevation of the IL-1beta level could possibly be attributed to transient mobilization of monocytes caused by sympathetic nervous activation. Moreover, a transient increase of IL-1beta might be conveyed to the brain and play a role in forming negative emotional states.
Yamakawa
Kaori
K
Department of Psychology, Nagoya University, Chikusa-ku, Aichi, Japan. yamakawa.kaori@g.mbox.nagoya-u.ac.jp
Matsunaga
Masahiro
M
Isowa
Tokiko
T
Kimura
Kenta
K
Kasugai
Kunio
K
Yoneda
Masashi
M
Kaneko
Hiroshi
H
Ohira
Hideki
H
D000293:Adolescent; D000704:Analysis of Variance; D015703:Antigens, CD / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D016207:Cytokines / Q000097:blood* / Q000145:classification; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007694:Killer Cells, Natural / Q000502:physiology; D008297:Male; D011581:Psychological Tests; D013223:Statistics as Topic; D013315:Stress, Psychological / Q000097:blood* / Q000503:physiopathology / Q000523:psychology; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology; D013997:Time Factors; D055815:Young Adult
D015703:Antigens, CD; D016207:Cytokines; D053583:Interleukin-1beta; D015850:Interleukin-6; D006854:Hydrocortisone