An assessment of potential cancer risk following occupational exposure to ethanol.
Recognition of the carcinogenic properties of ethanol has resulted from comprehensive evidence regarding the effect of consumption of alcohol; indeed, ethanol in alcoholic beverages is now considered a Group 1 carcinogen by the International Agency for Research on Cancer. However, there is little information on the effects of ethanol following exposure via the occupationally relevant routes of inhalation and dermal exposure. This review therefore focuses on these exposure routes, to assess potential carcinogenic risk associated with occupational exposure to ethanol. Inhalatory exposure at the current occupational exposure limit (OEL) for the United Kingdom (1000 ppm ethanol over an 8-h shift) was estimated to be equivalent to ingestion of 10 g ethanol (approximately 1 glass of alcohol) per day. However, in the occupational setting the dose-rate delivery of this amount of ethanol is low, allowing for its rapid and effective elimination, for the majority of individuals. Similarly, while dermal absorption in an occupational setting could potentially add to overall body ethanol burden, additional carcinogenic risk of such exposure is considered negligible. Thus, on balance, there appears little cause to suppose occupational exposure at or below the current OEL associates with any appreciable increase in risk of cancer. However, available occupational exposure data to confirm this view are currently limited. It is also suggested that adoption of a more flexible classification regime, considering risk in the context of hazard and exposure (such as that adopted by the German MAK commission), would represent an improvement over traditional occupational risk assessment practices.
Bevan
Ruth J
RJ
Institute of Environment and Health, Cranfield Health, Cranfield University, Bedfordshire, United Kingdom. r.bevan@cranfield.ac.uk
Slack
Rebecca J
RJ
Holmes
Philip
P
Levy
Leonard S
LS
D000279:Administration, Cutaneous; D000818:Animals; D000830:Animals, Laboratory; D002273:Carcinogens / Q000493:pharmacokinetics / Q000633:toxicity*; D000431:Ethanol / Q000493:pharmacokinetics / Q000633:toxicity*; D005770:Gastrointestinal Neoplasms / Q000209:etiology*; D041981:Gastrointestinal Tract / Q000187:drug effects*; D006801:Humans; D019570:Inhalation Exposure; D016273:Occupational Exposure / Q000009:adverse effects*; D018570:Risk Assessment; D012869:Skin Absorption
D002273:Carcinogens; D000431:Ethanol