title: Double-lumen central venous catheters impregnated with chlorhexidine and silver sulfadiazine to prevent catheter colonisation in the intensive care unit setting: a prospective randomised study.
abstract: Antimicrobial- and antiseptic-impregnated catheters are strategies recommended to prevent central venous catheter (CVC) colonisation. Few data regarding chlorhexidine/silver sulfadiazine-impregnated catheters in intensive care unit (ICU) patients have been reported. We performed a prospective, randomised study comparing the colonisation rates of chlorhexidine/silver sulfadiazine-impregnated CVCs (group 1) against standard CVCs (group 2). In order to assess catheter colonisation rates, a 4cm segment from the tips of aseptically removed catheters was cultured by the roll-plate method. In all, 109 patients were enrolled with successful catheter insertion, 51 of them in group 1 and 58 in group 2. There were no statistically significant differences between the two groups with regards to age, Sequential Organ Failure Assessment (SOFA) score, ICU admission diagnosis, infection risk, catheter insertion sites or catheter length of stay. The colonisation rates were 29.4% (15 catheters) for group 1 and 34.5% (20 catheters) for group 2 (P=0.50). Double-lumen CVCs impregnated with chlorhexidine and silver sulfadiazine were not effective in reducing the incidence of catheter colonisation in ICU patients.
authors.affiliation: Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil. luisfacamargo@uol.com.br
authors.forename: L F A
authors.initials: LF
authors.lastname: Camargo
authors.forename: A R
authors.initials: AR
authors.lastname: Marra
authors.forename: G L
authors.initials: GL
authors.lastname: Büchele
authors.forename: A M C
authors.initials: AM
authors.lastname: Sogayar
authors.forename: R G R
authors.initials: RG
authors.lastname: Cal
authors.forename: J M A
authors.initials: JM
authors.lastname: de Sousa
authors.forename: E
authors.initials: E
authors.lastname: Silva
authors.forename: E
authors.initials: E
authors.lastname: Knobel
authors.forename: M B
authors.initials: MB
authors.lastname: Edmond
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000302:isolation & purification; D055499:Catheter-Related Infections / Q000517:prevention & control*; D002404:Catheterization; D002710:Chlorhexidine / Q000494:pharmacology*; D004864:Equipment and Supplies / Q000382:microbiology*; D005260:Female; D005658:Fungi / Q000302:isolation & purification; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012837:Silver Sulfadiazine / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002710:Chlorhexidine; D012837:Silver Sulfadiazine