title: Turner's syndrome and subclinical autoimmune thyroid disease: a two-year follow-up study.
abstract: Although autoimmune thyroid disease (AITD) is frequent in Turner's syndrome (TS), followup studies are scant, and there are none regarding subclinical thyroiditis. We investigated thyroid function and morphology in 17 patients with TS (mean age 14.6 years) with transient and asymptomatic variations of TSH and/or thyroid hormones. Our 2-year follow-up included measurements of TSH, free T4, T3 and TPO and Tg antibodies, ultrasound (US) (first and last evaluations) and scintigraphy (first evaluation). Thyroid volume was evaluated relative to the patients' stature. Fourteen had abnormal hormones, including four with hypothyroidism and one with hyperthyroidism, ten had positive antibodies, and all had abnormalities on US; uptake was normal in 14/16. Abnormal hormones were independent of antibodies, number of US findings, age, time of disease and volume. At the end of the follow-up, antibodies were associated with a high number of abnormal US features, particularly heterogeneous texture. Our results indicate that recurring thyroid hormone variations in TS are due to chronic AITD.
authors.affiliation: Pediatric Endocrinology Service, Department of Pediatrics, Faculty of Medical Sciences, State University of Campinas, Brazil.
authors.forename: Carla C M
authors.initials: CC
authors.lastname: Medeiros
authors.forename: Sofia H V
authors.initials: SH
authors.lastname: de Lemos-Marini
authors.forename: Milton Brícola
authors.initials: MB
authors.lastname: Filho
authors.forename: Edwaldo E
authors.initials: EE
authors.lastname: Camargo
authors.forename: Allan O
authors.initials: AO
authors.lastname: Santos
authors.forename: Luis A
authors.initials: LA
authors.lastname: Magna
authors.forename: Gil
authors.initials: G
authors.lastname: Guerra-Júnior
authors.forename: Maria Tereza M
authors.initials: MT
authors.lastname: Baptista
authors.forename: Andréa T
authors.initials: AT
authors.lastname: Maciel-Guerra
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D011877:Radionuclide Imaging; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000097:blood; D013967:Thyroiditis, Autoimmune / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014424:Turner Syndrome / Q000097:blood / Q000503:physiopathology*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D013963:Thyroid Hormones