What are the clinical implications of nodular gastritis? Clues from histopathology.
There is no widely accepted histopathological definition for nodular gastritis. In this study we aim to uncover the pathologic entity responsible for the nodular appearance and to find clues about the clinical implications of nodular gastritis. Antral biopsy specimens of 160 patients with nodular gastritis and 133 patients without nodular gastritis were examined by an experienced pathologist for dysplasia, foveolar hyperplasia, inflammatory activity, intraepithelial lymphocytosis, intestinal metaplasia, and lymphoid follicle/aggregate formation, and comparative analysis was performed between the two groups of patients. The presence of intraepithelial lymphocytosis was more frequent in patients with nodular gastritis (P < 0.05). There was no difference between the two groups regarding the other pathological features such as presence of dysplasia, inflammatory activity, intestinal metaplasia, lymphoid hyperplasia, and Helicobacter pylori (H. pylori) infection. Increase of intraepithelial lymphocytes may contribute to formation of macroscopical nodules in this peculiar type of gastritis. Nodular gastritis would not indicate a new therapeutic approach in addition to the current measures for Helicobacter pylori infection.
Sokmensuer
Cenk
C
Department of Pathology, Hacettepe University Medical School, Ankara, Turkey.
Onal
Ibrahim Koral
IK
Yeniova
Ozgur
O
Ersoy
Osman
O
Aydinli
Musa
M
Yonem
Ozlem
O
Harmanci
Ozgur
O
Onal
Eda Demir
ED
Altinok
Gulcin
G
Batman
Figen
F
Bayraktar
Yusuf
Y
D001706:Biopsy; D005260:Female; D005756:Gastritis / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D006965:Hyperplasia; D006984:Hypertrophy; D007249:Inflammation; D008218:Lymphocytosis / Q000473:pathology; D008297:Male; D008875:Middle Aged