title: The management of infants and children treated with aciclovir for suspected viral encephalitis.
abstract: OBJECTIVE
  To investigate how infants and children with suspected viral encephalitis are currently managed in a UK tertiary children's hospital.
  
  
  METHODS
  Case notes of all infants and children who received intravenous aciclovir for suspected encephalitis over a 6-month period were reviewed. Suspected viral encephalitis was defined as a child with fever or history of febrile illness and a reduced level of consciousness, irritability or a change in personality or behaviour or focal neurological signs.
  
  
  RESULTS
  Fifty one children were identified. Two had proven herpes simplex encephalitis (HSV) and two had clinically diagnosed viral encephalitis with no cause identified. Forty children had cerebrospinal fluid (CSF) analysis, but basic results were incomplete in 13 cases. CSF was sent for the detection of HSV DNA by PCR in 27 cases. The initial dose of aciclovir was incorrect in 38 cases. The median (range) length of intravenous aciclovir treatment was 4 (1-21) days. Six children were given a full course of aciclovir (10 or more days). For 14 children, there appeared to be no real indication for starting aciclovir. Case note documentation was generally inadequate.
  
  
  CONCLUSIONS
  The management of children with suspected viral encephalitis appears haphazard in many cases. Guidelines for the management of children with suspected viral encephalitis are needed.
authors.affiliation: Department of Neurology, Littlewood's Neuroscience Unit, Alder Hey Children's NHS Foundation Trust, Liverpool, UK. rachel.kneen@alderhey.nhs.uk
authors.forename: Rachel
authors.initials: R
authors.lastname: Kneen
authors.forename: Srinivasa
authors.initials: S
authors.lastname: Jakka
authors.forename: Renuka
authors.initials: R
authors.lastname: Mithyantha
authors.forename: Andrew
authors.initials: A
authors.lastname: Riordan
authors.forename: Tom
authors.initials: T
authors.lastname: Solomon
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D004334:Drug Administration Schedule; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy; D018792:Encephalitis, Viral / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D018139:Simplexvirus / Q000302:isolation & purification; D013129:Spinal Puncture; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D000212:Acyclovir