title: Clinical correlations between treatment with anticoagulants/antiaggregants and late rectal toxicity after radiotherapy for prostate cancer.
abstract: OBJECTIVE
  To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy.
  
  
  METHODS
  A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformal radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT); fifty patients used anticoagulants/antiaggregants for vascular disease.
  
  
  RESULTS
  The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6% . On multivariate analysis, medication with anticoagulants/antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not.
  
  
  CONCLUSIONS
  Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.
authors.affiliation: Department of Radiation Oncology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendaishi 980-8574, Japan. takedak41@yahoo.co.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Takeda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Hisanori
authors.initials: H
authors.lastname: Ariga
authors.forename: Masashi
authors.initials: M
authors.lastname: Koto
authors.forename: Toru
authors.initials: T
authors.lastname: Sakayauchi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Kakutaro
authors.initials: K
authors.lastname: Narazaki
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Mitsuya
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takai
authors.forename: Shogo
authors.initials: S
authors.lastname: Yamada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects; D012007:Rectum / Q000528:radiation effects*
chemical_list: D000726:Androgen Antagonists; D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors