Surgical approach in patients with T4 bladder cancer as primary treatment: Disaster or option with improved quality of life.
OBJECTIVE
Whereas local control is often insufficient in conservative management of T4 bladder cancer, neoadjuvant chemotherapy delays definite treatment, which could result in increased therapy-associated morbidity and mortality during the course of the disease. Primary cystectomy has been reported to be associated with a high complication rate and unsatisfactory clinical efficacy. Herein, we report postoperative outcome in 21 T4 bladder cancer patients subjected to primary cystectomy.


METHODS
Twenty-one patients underwent radical cystectomy for T4 (T4a/b: 14 and seven cases, respectively) bladder cancer. At the time of surgery, eight patients had regional lymph node metastases (N2: 6; N3: 2). The average age was 64 (52-77) years (>/=70 years: n = 7). The postoperative follow-up was 13 (1-36) months for the whole group.


RESULTS
Mean duration of postoperative hospitalization was 19 (11-50) days. Whereas 10 patients received no intra - or postoperative blood transfusions, an average number of 3 (1-7) blood units were administered in the remaining cases. The mean postoperative hemoglobin value of patients not receiving any blood transfusions was 10 (8.5 - 11.4) g/dl. Major therapy-associated complications were paresthesia affecting the lower extremities (n = 3) as well as insignificant pulmonary embolism, enterocutaneous fistulation and acute renal failure in one patient, respectively. At the time of data evaluation, 11 patients were still alive after a follow-up of 20 (6-36) months. Four patients >/=70 years at the time of cystectomy were still alive 11, 11, 22 and 31 months following surgery, respectively.


CONCLUSIONS
Primary cystectomy for T4 bladder cancer is a technically feasible approach that is associated with a tolerable therapy-related morbidity/mortality. Additionally, a satisfactory clinical outcome is observed even in a substantial number of elderly patients.
Nagele
Udo
U
Department of Urology, Eberhard-Karls-University, Tübingen, Germany.
Anastasiadis
Aristotelis G
AG
Merseburger
Axel S
AS
Hennenlotter
Jörg
J
Horstmann
Markus
M
Sievert
Karl-Dietrich
KD
Stenzl
Arnulf
A
Kuczyk
Markus A
MA