The effect of subacute supplementation of taurine on spatial learning and memory.
Although the effect of taurine on the heart and liver is well studied, there has been no direct observation concerning the effect of taurine on spatial learning and memory at the behavior level. In this study, we tested the effect of subacute taurine supplementation with evaluation by the Morris water maze method. Although swim distance to find the platform of taurine-supplemented rats was significantly longer than that of control rats due to increase of swimming velocity, escape latency and the efficacy of learning and memory was comparable in both groups. These results suggest that taurine supplemented orally does not affect the learning and memory function.
Ito
Koichi
K
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Arko
Matevz
M
Kawaguchi
Tomohiro
T
Kuwahara
Masayoshi
M
Tsubone
Hirokazu
H
D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects; D019587:Dietary Supplements; D004924:Escape Reaction / Q000187:drug effects; D005503:Food Additives / Q000008:administration & dosage*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D013550:Swimming / Q000502:physiology; D013654:Taurine / Q000008:administration & dosage*
D005503:Food Additives; D013654:Taurine