title: Molecular and phenotypic characterization of invasive group B streptococcus strains from infants in Norway 2006-2007.
abstract: Multilocus sequence typing of an almost complete collection of invasive group B streptococcus (GBS) strains from infants in Norway, conducted in 2006-2007, revealed 27 sequence types (ST), of which 23 clustered into five clonal complexes. The case fatality rate of invasive GBS disease in infants was 16/98 (16.3%). Type V strains were predominant among strains resistant to erythromycin and clindamycin (11/18; 61.1%). All type V strains from fatal cases (5/16) were ST1, resistant to erythromycin and clindamycin, and belonged to three pulsed-field gel electrophoresis-clusters. Further analysis of virulence characteristics of these apparently highly virulent subtypes of type V, ST1 GBS strains is warranted.
authors.affiliation: Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway. hakon.bergseng@ntnu.no
authors.forename: H
authors.initials: H
authors.lastname: Bergseng
authors.forename: J E
authors.initials: JE
authors.lastname: Afset
authors.forename: A
authors.initials: A
authors.lastname: Radtke
authors.forename: K
authors.initials: K
authors.lastname: Loeseth
authors.forename: R V
authors.initials: RV
authors.lastname: Lyng
authors.forename: M
authors.initials: M
authors.lastname: Rygg
authors.forename: K
authors.initials: K
authors.lastname: Bergh
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques; D002981:Clindamycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D004917:Erythromycin / Q000494:pharmacology; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D009664:Norway / Q000453:epidemiology; D010641:Phenotype; D017422:Sequence Analysis, DNA; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D013292:Streptococcus agalactiae / Q000145:classification* / Q000187:drug effects / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002981:Clindamycin; D004917:Erythromycin