title: The chemokine-binding protein M3 as a tool to understand the chemokine network in vivo.
abstract: Murine herpesvirus 68 (MHV-68) codes for a secreted chemokine-binding protein, termed M3, which interacts with a broad range of chemokines with very high affinity, inhibiting chemokine function both in vitro and in vivo. Here we describe the transgenic methodology used to study the role of M3 as an immune modulator in vivo.
authors.affiliation: Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Lira
authors.forename: Abel
authors.initials: A
authors.lastname: Viejo-Borbolla
authors.forename: Limin
authors.initials: L
authors.lastname: Shang
authors.forename: Andrea P
authors.initials: AP
authors.lastname: Martin
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects / Q000235:genetics; D018925:Chemokines / Q000378:metabolism* / Q000494:pharmacology; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D018144:Rhadinovirus / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D018925:Chemokines; C118862:M3 protein, Murine gammaherpesvirus; D014764:Viral Proteins