Primary cutaneous blastoid mantle cell lymphoma-case report.
Mantle cell lymphoma (MCL) commonly involves extranodal sites, usually as a manifestation of disseminated disease. In rare cases, MCLs may arise as a primary tumor in the skin. Blastoid mantle cell lymphoma (BV-MCL) is a rare variant and has a more aggressive clinical course. The phenotype of BV-MCL is characterized as CD20+, CD5+, cyclin D1+, CD23-, and CD10-. Interphase fluorescence in situ hybridization shows a characteristic t(11;14) fusion pattern. We report a case of a BV-MCL arising in skin as primary cutaneous MCL with the characteristic immunophenotype and translocation.
Estrozi
Bruna
B
Pathology Reference Laboratory, Botucatu, São Paulo, Brazil.
Sanches
José A
JA
Varela
Paulo C S
PC
Bacchi
Carlos E
CE
D000368:Aged; D001706:Biopsy; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000235:genetics* / Q000473:pathology*; D008297:Male; D010641:Phenotype; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology*; D014178:Translocation, Genetic