[Hormonal control of human hydratation status in space flight].
In long-lasting stay in state of weightlessness the astronaut develops a moderate hypophydratation of the organism accompanied by increase production of vasopressin. Most changes of the water-salt balance and kidney function will be fast enough normalised. The synthetic agonist of vasopressin V2-receptors proved to be able to control human hydratation status. The data obtained indicate a certain efficacy of Desmopressin thus opening prospects for development of a simple pharmacological means of prophylactics of the weightlessness effect.
Grigor'ev
A I
AI
Noskov
V B
VB
D000222:Adaptation, Physiological / Q000187:drug effects*; D018480:Astronauts; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage*; D006801:Humans; D017483:Receptors, Vasopressin / Q000819:agonists / Q000502:physiology*; D013026:Space Flight; D014882:Water-Electrolyte Balance / Q000187:drug effects* / Q000502:physiology; D014893:Weightlessness / Q000009:adverse effects*
D017483:Receptors, Vasopressin; D003894:Deamino Arginine Vasopressin