Preparation, antibacterial properties and biocompatibility studies on vancomycin-poly(D,L)-lactic loaded plates.
In the clinic, implant-associated infections are the chief risk facing orthopaedics and traumatology departments. Vancomycin-poly(D,L)-lactic acid (PDLLA) loaded plates were prepared by using solvent casting technology. The bacteriostatic activity to Staphylococcus aureus was evaluated in vitro. The biocompatibility of the plates was investigated by acute systemic toxicity test, haemolytic test, cytotoxicity test, etc. The in vitro inhibition test of Staphylococcus aureus showed that the plates had an inhibitory effect on Staphylococcus aureus. There was no toxicity for the vancomycin-PDLLA loaded plates. There was a good biocompatibility for the vancomycin-PDLLA loaded plates. These findings indicate that the plate maybe used to prevent or cure infection.
Tang
Lianghua
L
Department of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Zhao
Changhong
C
Xiong
Yan
Y
Wang
Aimin
A
D000497:Alloys; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D001860:Bone Plates; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects*; D014025:Titanium / Q000008:administration & dosage; D018675:Toxicity Tests; D014640:Vancomycin / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry
D000497:Alloys; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D014640:Vancomycin; D014025:Titanium