title: Toltrazuril and sulphonamide treatment against naturally Isospora suis infected suckling piglets: is there an actual profit?
abstract: A study was carried out to assess the efficacy and the economic profit of prophylactic treatment against Isopsora suis with toltrazuril or with a sulfamethazine/trimethoprim combination in piglets from an intensive pig farm. Thirty-one litters were included in study. Eight litters were treated once with toltrazuril (20 mg/kg b.w.) at 3 days of age (Toltra group); 8 litters were treated with 2 ml/animal of a [corrected] sulphonamide combination (sodium sulfamethazine 250 [DOSAGE ERROR CORRECTED] mg and trimethoprim 50 [DOSAGE ERROR CORRECTED] mg/kg b.w.) for 3 consecutive days starting at 3 days of age (Sulfa group), and 15 litters were untreated (control group). Counts of oocyst per gram on pooled feces sampled from each litter were carried out on Days 7, 14, 21 and 28 and diarrhea was registered daily from pooled samples. Piglets were weighed on Days 1, 7 and 28 and mean weight gain (WG) and daily weight gain (DWG) were evaluated. The economic profit of treatment was evaluated comparing the WG of piglets of each treatment group from the day of birth to Day 28. On Days 14, 21 and 28, toltrazuril showed a better efficacy in controlling fecal oocyst output, diarrhea and weight gain compared with sulphamidic treatment (P<0.001). The budgeting analysis showed a return of economic benefit of euro 0.915 per toltrazuril-treated piglets and an additional cost of euro 1.155 per sulphonamide-treated piglets.
authors.affiliation: Department of Animal Biology, Section of Parasitology and Parasitic Diseases, Università degli Studi, 07100 Sassari, Italy. scala@uniss.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Scala
authors.forename: Francesca
authors.initials: F
authors.lastname: Demontis
authors.forename: Antonio
authors.initials: A
authors.lastname: Varcasia
authors.forename: Anna Paola
authors.initials: AP
authors.lastname: Pipia
authors.forename: Giovanni
authors.initials: G
authors.lastname: Poglayen
authors.forename: Nicola
authors.initials: N
authors.lastname: Ferrari
authors.forename: Marco
authors.initials: M
authors.lastname: Genchi
mesh_terms: D000818:Animals; D000833:Animals, Suckling / Q000254:growth & development; D003049:Coccidiostats / Q000191:economics* / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D004359:Drug Therapy, Combination / Q000662:veterinary; D005243:Feces / Q000469:parasitology; D007549:Isospora / Q000187:drug effects; D021865:Isosporiasis / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D013418:Sulfamethazine / Q000191:economics / Q000627:therapeutic use; D013449:Sulfonamides / Q000191:economics / Q000627:therapeutic use*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*; D016896:Treatment Outcome; D014227:Triazines / Q000191:economics / Q000627:therapeutic use*; D014295:Trimethoprim / Q000191:economics / Q000627:therapeutic use; D015430:Weight Gain
chemical_list: D003049:Coccidiostats; D013449:Sulfonamides; D014227:Triazines; D013418:Sulfamethazine; D014295:Trimethoprim; C036670:toltrazuril