Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population.
We report a significantly higher occurrence of HLA-DRB1*09 (51% vs. 23%, P = 0.002, OR = 3.57) and HLA-B*46-DRB1*09 (26% vs. 8%, P = 0.018, OR = 3.76) in patients with haemorrhagic fever with renal syndrome (HFRS) compared to the control group, suggesting Hantaan virus-induced HFRS is associated with a genetic predisposition in the Chinese Han population.
Wang
M L
ML
Department of Immunology, Fourth Military Medical University, 17 Changle West Road, Xi'an, China.
Lai
J H
JH
Zhu
Y
Y
Zhang
H B
HB
Li
C
C
Wang
J P
JP
Li
Y M
YM
Yang
A G
AG
Jin
B Q
BQ
D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D018063:Hantaan virus; D006239:Haplotypes / Q000235:genetics; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D016015:Logistic Models; D012189:Retrospective Studies
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains