[Eradication of hepatitis C virus after a 5-week treatment].
The standard regimen for the treatment of chronic hepatitis C virus (HCV) is peginterferon alpha-2a or -2b associated with ribavirine. The recommended duration of treatment for genotype 2 HCV infection is 24 weeks. However, the relatively poor drug tolerance often leads to a reduction or a discontinuation of the treatment. Here, we report two female patients who discontinued antiviral therapy after less than 6 weeks for intolerance and who experienced a sustained virological response. A treatment of 3 to 5 weeks may be enough for genotype 2 HCV eradication. However, there is not sufficient evidence in 2009 to recommend a reduced treatment duration.
Gaundong Mbéthé
G L
GL
Service d'hépatogastro-entérologie, hôpital Haut-Lévêque, CHU de Bordeaux, Pessac cedex, France. gaundong@yahoo.fr
Foucher
J
J
DeLedinghen
V
V
Couzigou
V P
VP
D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D055118:Medication Adherence; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011994:Recombinant Proteins; D012254:Ribavirin / Q000627:therapeutic use
D000998:Antiviral Agents; D004279:DNA, Viral; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a