[Experimental study progress on tribendimidine, artemether and artesunate against Clonorchis sinensis and other trematodes].
Currently praziquantel is one of the major drugs used in treatment of schistosomiasis and other trematode infections. Recent experimental studies indicate that a new anthelmintic, tribendimidine, is used in the treatment of intestinal nematodes, also possesses effect against several species of trematodes including Clonorchis sinensis, Opisthorchis viverrini and Echinostoma caproni. Tribendimidine is even more effective against C. sinensis in rats that a single 300 mg/kg oral dose cures almost all of the animals treated, a lower cure dose than praziquantel (375-500 mg/kg). The anti-malarial drugs artemether and artesunate are not only effective in the prevention of schistosomiasis, but also effective against several species of trematodes, especially C. sinensis. The single oral dose of both drugs to cure or achieve high efficacy in infected rats is 75 mg/kg. This review summarized research progress on tribendimidine, artesunate, and artemether in experimental animals infected with C. sinensis and other species of trematodes.
Xiao
Shu-hua
SH
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China. shxiao4@hotmail.com
Xue
Jian
J
Wu
Zhong-xin
ZX
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000077549:Artemether; D037621:Artemisinins / Q000627:therapeutic use*; D000077332:Artesunate; D003003:Clonorchiasis / Q000188:drug therapy* / Q000469:parasitology; D003004:Clonorchis sinensis / Q000187:drug effects; D006224:Cricetinae; D004285:Dogs; D010655:Phenylenediamines / Q000627:therapeutic use*; D051381:Rats; D014200:Trematoda / Q000187:drug effects; D014201:Trematode Infections / Q000188:drug therapy / Q000469:parasitology
D000871:Anthelmintics; D037621:Artemisinins; D010655:Phenylenediamines; C056017:tribendimidine; D000077332:Artesunate; D000077549:Artemether