Titanium(IV) halide mediated coupling of alkoxides and alkynes: an efficient and stereoselective route to trisubstituted (E)-alkenyl halides.
Alkoxide C-O bond cleavage occurs readily at room temperature in the presence of titanium(IV) halide. Capture of the resultant carbocation by alkynes provides an efficient route to trisubstituted (E)-alkenyl halides with high stereoselectivity.
Yao
Min-Liang
ML
Department of Chemistry, The University of Tennessee, Knoxville, Tennessee 37996-1600, USA.
Quick
Travis R
TR
Wu
Zhongzhi
Z
Quinn
Michael P
MP
Kabalka
George W
GW