Burning mouth syndrome.
BACKGROUND
Burning mouth syndrome mainly affects women, particularly after the menopause, when its prevalence may be 18-33%.


METHODS
We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for burning mouth syndrome? We searched: Medline, Embase, The Cochrane Library, and other important databases up to February 2007 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).


RESULTS
We found 12 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.


CONCLUSIONS
In this systematic review we present information relating to the effectiveness and safety of the following interventions: anaesthetics (local), antidepressants, benzodiazepines (topical clonazepam), benzydamine hydrochloride, cognitive behavioural therapy (CBT), dietary supplements, and hormone replacement therapy (HRT) in postmenopausal women.
Buchanan
John
J
Barts and The London School of Medicine and Dentistry, Dental Institute, Royal London Hospital, London, UK.
Zakrzewska
Joanna
J
D000928:Antidepressive Agents / Q000627:therapeutic use; D001569:Benzodiazepines / Q000627:therapeutic use; D002054:Burning Mouth Syndrome / Q000188:drug therapy; D002998:Clonazepam / Q000627:therapeutic use; D006801:Humans
D000928:Antidepressive Agents; D001569:Benzodiazepines; D002998:Clonazepam