Appearance of ring sideroblasts in bone marrow during linezolid therapy.
A female patient with renal dysfunction developed thrombocytopenia after 2 weeks of linezolid treatment. Her bone marrow showed abnormal erythroblast morphology and abundant ring sideroblasts. No chromosomal abnormalities or other signs of myelodysplasia were seen in an early follow-up bone marrow aspirate, where the abnormal morphological findings had almost totally subsided.
Ebeling
Freja
F
Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland. freja.ebeling@hus.fi
Helminen
Päivi
P
Anttila
Veli-Jukka
VJ
D000081:Acetamides / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001707:Biopsy, Needle; D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D004900:Erythroblasts / Q000187:drug effects / Q000473:pathology*; D004920:Erythropoiesis / Q000187:drug effects; D005260:Female; D006801:Humans; D000069349:Linezolid; D008875:Middle Aged; D023303:Oxazolidinones / Q000009:adverse effects*; D010976:Platelet Count
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid