title: The effect of preoperative aspirin administration on postoperative level of von Willebrand factor in off-pump coronary artery bypass surgery.
abstract: The effect of preoperative administration of aspirin on endothelial function in the patients undergoing off-pump coronary artery bypass (OPCAB) surgery is still unclear. Fifty consecutive patients undergoing OPCAB between May 2006 and May 2007 were equally divided into two groups - one without preoperative aspirin (group A; the first 25 patients) and the other with preoperative aspirin (group B; the next 25 patients). We investigated the degree of postoperative endothelial dysfunction by measuring the von Willebrand factor activity, which is a possible indicator of endothelial damage. The level of von Willebrand factor was not different between groups before surgery (group A 166% +/- 53% vs group B 181% +/- 62%; P = 0.39). Immediately after surgery it was significantly higher than before surgery in group A (231% +/- 79%; rate of increase 1.24 +/- 0.58), but not in group B (183% +/- 77%; rate of increase 1.03 +/- 0.55) (P < 0.02). The level was still significantly higher in group A than in group B on postoperative day 1 (group A 294 +/- 66 vs 254 +/- 51; P = 0.03), but there was no difference between groups on postoperative day 6. Although the frequency of blood transfusion was higher in group B, there was no difference in the amount of intraoperative bleeding between the groups. Preoperative use of aspirin before OPCAB could suppress the postoperative increase in von Willebrand factor, a possible indicator of endothelial damage, only in the early postoperative phase.
authors.affiliation: Division of Cardiovascular Surgery, Department of Surgery, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 565-8565, Japan. km4717jp@yahoo.co.jp
authors.forename: Kaoru
authors.initials: K
authors.lastname: Matsuura
authors.forename: Mizuho
authors.initials: M
authors.lastname: Imamaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ishida
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shimura
authors.forename: Masaru
authors.initials: M
authors.lastname: Miyazaki
mesh_terms: D000368:Aged; D001241:Aspirin / Q000008:administration & dosage*; D047549:Coronary Artery Bypass, Off-Pump; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D016896:Treatment Outcome; D014841:von Willebrand Factor / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism
chemical_list: D005343:Fibrinolytic Agents; D014841:von Willebrand Factor; D001241:Aspirin