Semisynthesis and antiproliferative evaluation of a series of 3'-aminoflavones.
A series of 3'-aminoflavones 5,6,7,8-tetra- or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus flavonoids. These flavones were evaluated for antiproliferative activity, activation of apoptosis, and inhibition of tubulin assembly. The most antiproliferative flavones exhibit a common 5-hydroxy-6,7,8-trimethoxy substitution pattern on the A-ring.
Quintin
Jérôme
J
Laboratoire de Pharmacognosie, (Univ. Paris-Sud 11, BIOCIS, UMR-8076 CNRS), Faculté de Pharmacie, av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France.
Buisson
Didier
D
Thoret
Sylviane
S
Cresteil
Thierry
T
Lewin
Guy
G
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D044950:Flavanones / Q000737:chemistry; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006801:Humans
D000970:Antineoplastic Agents; D044950:Flavanones; D047309:Flavones; C059006:tangeretin; C005274:naringin