Serial assessment of left ventricular remodeling and function by echo-tissue Doppler imaging after myocardial infarction in streptozotocin-induced diabetic swine.
BACKGROUND
The aim of this study was to determine the value of Doppler tissue imaging (DTI) in detecting serial changes in left ventricular (LV) geometry and function after myocardial infarction (MI) in diabetic swine.


METHODS
Thirteen minipigs with streptozotocin-induced diabetes for 1 month and 13 controls were subjected to occlusion of the left anterior descending coronary artery. Echocardiography and DTI were performed before, 30 minutes, 90 minutes, and 4 weeks after left anterior descending coronary artery occlusion.


RESULTS
At baseline, LV end-diastolic volume and mass were greater in pigs with diabetes. After MI, LV ejection fractions and systolic mitral annular velocities were decreased and LV chambers dilated in both groups, which were exacerbated in animals with diabetes. At 30 minutes, 90 minutes, and 4 weeks after MI, strain rates were significantly lower in both infarct and noninfarct areas in the diabetic group than in controls.


CONCLUSIONS
DTI proved to be a useful tool in the serial assessment of subclinical LV dysfunction after MI in pigs with diabetes.
Ruan
Wen
W
Department of Cardiology, Rui Jin Hospital, Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Lu
Lin
L
Zhang
Qi
Q
Cao
Min
M
Zhu
Zheng Bin
ZB
Wang
Ling Jie
LJ
Shen
Wei Feng
WF
D000818:Animals; D048909:Diabetes Complications / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D013311:Streptozocin; D013552:Swine; D013556:Swine, Miniature; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000503:physiopathology*; D020257:Ventricular Remodeling
D013311:Streptozocin