[Study on optimization of formulation and preparation process of sinomenine liposomes].
OBJECTIVE
To optimize the formulation and preparation process of sinomenine liposomes.


METHODS
Method of aether injection and mixture uniform design were adopted to determine the formulation of sinomenine liposomes is the proportion of phospholipids, cholesterol and Vitamin E with the index of entrapment efficiency. And the single-factor test was used to study the preparation process of the liposomes, including the volume of buffer solution, the preparation temperature and the ultrasonic time.


RESULTS
The optimized formulation was that the ratio of sinomenine : phospholipids : cholesterol : vitamin E mass ratio was 8.92 : 60.35 : 28.81 : 1.91. The volume of buffer solution was 50 mL x g(-1) membrane, the preparation temperature was 50 degrees C, and the ultrasonic time was 20 min.


CONCLUSIONS
Satisfactory shape and entrapment efficiency of the liposomes can be obtained by the optimized formulation and preparation process.
Wang
Yan
Y
Section of Chinese Pharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China. gdpuwy@126.com
Cong
Zhenna
Z
Liu
Qingfei
Q
Ling
Jiajun
J
Zhou
Liling
L
D002626:Chemistry, Pharmaceutical; D002784:Cholesterol; D004304:Dosage Forms; D004337:Drug Carriers; D004339:Drug Compounding / Q000191:economics / Q000379:methods; D016503:Drug Delivery Systems; D004355:Drug Stability; D008081:Liposomes; D009019:Morphinans / Q000493:pharmacokinetics*; D010316:Particle Size; D010743:Phospholipids; D013678:Technology, Pharmaceutical
D004304:Dosage Forms; D004337:Drug Carriers; D008081:Liposomes; D009019:Morphinans; D010743:Phospholipids; C009271:sinomenine; D002784:Cholesterol