microRNAs: novel components in a muscle gene regulatory network.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level via translational inhibition or mRNA degradation. Emerging evidence supports that miRNAs play critical roles in skeletal and cardiac muscle, as both muscle-specific and non-muscle-specific miRNAs are required for the development and differentiation of these tissues. Their interactions with myogenic factors also integrate miRNAs into a complex regulatory network underlying myogenesis. Furthermore, their dysregulation and associated pathologies suggest that miRNA-based therapies may be effective in treating muscle-related disorders.
Wang
Huating
H
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and The Arthur G James Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.
Sun
Hao
H
Guttridge
Denis C
DC
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D024510:Muscle Development / Q000235:genetics*; D009132:Muscles / Q000378:metabolism*; D009135:Muscular Diseases / Q000235:genetics / Q000628:therapy*
D035683:MicroRNAs