title: Long-term results after resection for soft tissue sarcoma pulmonary metastases.
abstract: Isolated pulmonary metastases from soft tissue sarcomas (STS) occur in approximately 20% of the cases. Chemotherapy and surgical resection are the current standard treatment options for these patients. Our goal was to identify any prognostic factors for these patients as well as to estimate their long-term survival rate. We examined a series of twenty-two consecutive patients with pulmonary metastases from STS, treated in our institution from 1996 to 2006. Univariate (log-rank and Cox-regression) analysis was performed to identify any significant prognostic factor. Five-year survival rates were estimated by using Kaplan-Meier methods. Four patients (18.2%) were alive without any disease, twelve patients (54.5%) died of disease and we lost all track of six patients (27.3%). Follow-up period ranged from 7 to 75 months. Median follow-up: 14 months, median survival: 19 months. Disease-free interval (DFI) (P=0.005), number of lung nodules (P=0.04) and histology type (P=0.01) were significant prognostic factors at univariate analysis. The overall five-year survival rate was 23.1%. DFI, number of lung nodules at surgery and metastatic histology are significant prognostic factors for patients with resected pulmonary metastases from STS.
authors.affiliation: Department of General Thoracic Surgery, Clinica Universidad Navarra, Avenida Pio XII 36, Pamplona 31008, Spain. cegarciaf@unav.es
authors.forename: Carlos E
authors.initials: CE
authors.lastname: García Franco
authors.forename: Salvador Martín
authors.initials: SM
authors.lastname: Algarra
authors.forename: Akiko Tamura
authors.initials: AT
authors.lastname: Ezcurra
authors.forename: Francisco
authors.initials: F
authors.lastname: Guillén-Grima
authors.forename: Mikel
authors.initials: M
authors.lastname: San-Julián
authors.forename: Javier Pardo
authors.initials: JP
authors.lastname: Mindán
authors.forename: Wenceslao Torre
authors.initials: WT
authors.lastname: Buxalleu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012509:Sarcoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult