title: Epidemiology of biliary atresia in England and Wales (1999-2006).
abstract: OBJECTIVE
  To identify the epidemiological characteristics of infants with biliary atresia in England and Wales, since centralisation of its management in 1999.
  
  
  METHODS
  The care of infants with biliary atresia (BA) in England and Wales is centralised to only three centres. All infants (treated from January 1999 to December 2006) were identified from a prospective national database; demographic details were ascertained from medical records and compared between two groups based on presumed aetiology (isolated biliary atresia (IBA) and developmental biliary atresia (DBA) (for example, syndromic infants, biliary atresia splenic malformation, cystic biliary atresia)).
  
  
  RESULTS
  There were 302 (133 male (44%)) infants with BA that could be divided into IBA (n = 219, 73%) and DBA (n = 76, 25%). The overall incidence was 0.58/10 000 (1 in 17,049) live births with marked regional differences along a north-west/south-east axis varying from 0.38 (north-west England) to 0.78 (south-east England)/10,000 live births (OR 2.05 (95% CI 1.26-3.41); p = 0.002). The commonest month of birth was September with December being the least common, although there was no evidence for significant seasonal variation (p = 0.2). Infants with DBA were more likely to be female (p<0.001), of white background (p = 0.01), first-born (p = 0.04) and to be formula-fed (p = 0.07). Infants of south Asian origin came to surgery at an older age (59 (IQ 45-75) versus 52 (IQ 42-65) days; p = 0.03).
  
  
  CONCLUSIONS
  There is a remarkable variation of incidence of biliary atresia within England and Wales, some of which may have been caused by factors related to a different aetiological and racial background.
authors.affiliation: Paediatric Liver Centre, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
authors.forename: E
authors.initials: E
authors.lastname: Livesey
authors.forename: M
authors.initials: M
authors.lastname: Cortina Borja
authors.forename: K
authors.initials: K
authors.lastname: Sharif
authors.forename: N
authors.initials: N
authors.lastname: Alizai
authors.forename: P
authors.initials: P
authors.lastname: McClean
authors.forename: D
authors.initials: D
authors.lastname: Kelly
authors.forename: N
authors.initials: N
authors.lastname: Hadzic
authors.forename: M
authors.initials: M
authors.lastname: Davenport
mesh_terms: D001656:Biliary Atresia / Q000145:classification / Q000453:epidemiology*; D001724:Birth Weight; D004739:England / Q000453:epidemiology; D005006:Ethnicity; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D011159:Population Surveillance; D011446:Prospective Studies; D012111:Residence Characteristics; D012307:Risk Factors; D012621:Seasons; D014852:Wales / Q000453:epidemiology