title: Urea derivatives on the move: cytokinin-like activity and adventitious rooting enhancement depend on chemical structure.
abstract: Urea derivatives are synthetic compounds, some of which have proved to be positive regulators of cell division and differentiation. N-phenyl-N'-(2-chloro-4-pyridyl)urea (forchlorofenuron, CPPU) and N-phenyl-N'-(1,2,3-thiadiazol-5-yl)urea (thidiazuron, TDZ), well known urea cytokinin representatives, are extensively used in in vitro plant morphogenesis studies, as they show cytokinin-like activity often exceeding that of adenine compounds. In recent years, renewed interest in structure-activity relationship studies allowed identification of new urea cytokinins and other urea derivatives that specifically enhance adventitious root formation. In this review, we report the research history of urea derivatives, new insights into their biological activity, and recent progress on their mode of action.
authors.affiliation: Dipartimento di Biologia Evolutiva e Funzionale, Università di Parma, Parma, Italy. ada.ricci@unipr.it
authors.forename: A
authors.initials: A
authors.lastname: Ricci
authors.forename: C
authors.initials: C
authors.lastname: Bertoletti
mesh_terms: D000225:Adenine / Q000378:metabolism; D003583:Cytokinins / Q000737:chemistry / Q000378:metabolism*; D010671:Phenylurea Compounds / Q000737:chemistry / Q000378:metabolism; D063245:Plant Development; D010937:Plant Growth Regulators / Q000737:chemistry / Q000378:metabolism*; D018517:Plant Roots / Q000254:growth & development / Q000378:metabolism*; D010944:Plants / Q000378:metabolism*; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000737:chemistry / Q000378:metabolism; D014508:Urea / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism*
chemical_list: D003583:Cytokinins; D010671:Phenylurea Compounds; D010937:Plant Growth Regulators; D011725:Pyridines; D013830:Thiadiazoles; C016785:thidiazuron; D014508:Urea; D000225:Adenine; C116093:N-(2-chloro-4-pyridyl)-N'-phenylurea