title: Molecular recognition and self-assembly special feature: Squaring cooperative binding circles.
abstract: The cooperative binding effects of viologens and pyridines to a synthetic bivalent porphyrin receptor are used as a model system to study how the magnitudes of these effects relate to the experimentally obtained values. The full thermodynamic and kinetic circles concerning both activation and inhibition of the cage of the receptor for the binding of viologens were measured and evaluated. The results strongly emphasize the apparent character of measured binding and rate constants, in which the fractional saturation of receptors with other guests is linearly expressed in these constants. The presented method can be used as a simple tool to better analyze and comprehend the experimentally observed kinetics and thermodynamics of natural and artificial cooperative systems.
authors.affiliation: Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen, The Netherlands.
authors.forename: Alexander B C
authors.initials: AB
authors.lastname: Deutman
authors.forename: Cyrille
authors.initials: C
authors.lastname: Monnereau
authors.forename: Mohamed
authors.initials: M
authors.lastname: Moalin
authors.forename: Ruud G E
authors.initials: RG
authors.lastname: Coumans
authors.forename: Nico
authors.initials: N
authors.lastname: Veling
authors.forename: Michiel
authors.initials: M
authors.lastname: Coenen
authors.forename: Jan M M
authors.initials: JM
authors.lastname: Smits
authors.forename: René
authors.initials: R
authors.lastname: de Gelder
authors.forename: Johannes A A W
authors.initials: JA
authors.lastname: Elemans
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Ercolani
authors.forename: Roeland J M
authors.initials: RJ
authors.lastname: Nolte
authors.forename: Alan E
authors.initials: AE
authors.lastname: Rowan
mesh_terms: D001665:Binding Sites; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013816:Thermodynamics; D014755:Viologens / Q000737:chemistry*
chemical_list: D011166:Porphyrins; D011725:Pyridines; D014755:Viologens