title: Sex-dependent associations of leptin with metabolic syndrome-related variables: the Stanislas study.
abstract: Serum leptin has been reported to be associated in a sex-dependent manner with C-reactive protein (CRP), independently of adiposity. We tested the hypothesis that leptin is associated, independently of anthropometry indexes and in a sex-dependent way, with other inflammatory markers and variables related to metabolic syndrome (MS). In 384 healthy middle-aged adults (192 men and 192 women) total fat mass (FM), waist circumference (WC), serum leptin and 15 MS-related parameters (systolic and diastolic blood pressure, triglycerides, cholesterol, high density lipoprotein (HDL)-cholesterol, apo AI and B, fasting glucose, uric acid, CRP, orosomucoid and haptoglobin levels and aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and gamma-glutamyl transferase (GGT) activities) were measured. After adjustment for age, alcohol and cigarette consumption, WC, and total FM, leptin concentration was significantly associated with serum triglycerides, total cholesterol, apo B, uric acid and haptoglobin concentrations and liver enzyme activity only in men, and with apo AI, HDL-cholesterol (only borderline) and CRP only in women. Sex interaction terms were significant for total cholesterol, apo B, HDL cholesterol, uric acid, ALAT and GGT, and borderline significant for triglycerides, apo AI and ASAT. In this healthy population, leptin is significantly associated with various MS factors, independently of WC and total FM, depending on gender. Our study provides further evidence of sex-related differences mediated by leptin in inflammatory mechanisms and other MS-related metabolic pathways.
authors.affiliation: Faculty of Pharmacy, Henri Poincaré University, Nancy, France.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Samara
authors.forename: Bernard
authors.initials: B
authors.lastname: Herbeth
authors.forename: Roberte
authors.initials: R
authors.lastname: Aubert
authors.forename: Hind
authors.initials: H
authors.lastname: Berrahmoune
authors.forename: Frédéric
authors.initials: F
authors.lastname: Fumeron
authors.forename: Gérard
authors.initials: G
authors.lastname: Siest
authors.forename: Sophie
authors.initials: S
authors.lastname: Visvikis-Siest
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D017097:Electric Impedance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood; D055105:Waist Circumference / Q000502:physiology*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D020738:Leptin; D008055:Lipids; D014527:Uric Acid