title: Quality of life in osteoradionecrosis patients after mandible primary reconstruction with free fibula flap.
abstract: OBJECTIVE
  To evaluate the quality-of-life outcomes in osteoradionecrosis patients undergoing primary mandible reconstruction with free fibula flap, and to analyze the association between quality of life and demographic and medical characteristics of osteoradionecrosis patients.
  
  
  METHODS
  Quality-of-life outcomes of 15 patients after primary mandible reconstruction with free fibula flap for osteoradionecrosis were assessed using a modified University of Washington Quality of Life Questionnaire, version 4.
  
  
  RESULTS
  The best-scoring domain was pain, whereas the lowest scores occurred in chewing, swallowing, speech, and saliva. More than 70% of patients perceived improved health-related quality of life after reconstruction. Men scored significantly higher than women in speech domain, recreation domain, activity domain, and "social function." The time elapsed from radiotherapy was significantly and negatively correlated with the score of speech, recreation, and global question.
  
  
  CONCLUSIONS
  Mandible reconstruction with fibula flap effectively eliminates pain and controls local infection even though radiotherapy-induced complications still influence the quality of life of osteoradionecrosis patients.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Yu-Xiong
authors.initials: YX
authors.lastname: Su
authors.forename: Gui-Qing
authors.initials: GQ
authors.lastname: Liao
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000150:complications / Q000523:psychology* / Q000532:radiotherapy; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005360:Fibula / Q000637:transplantation; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000150:complications / Q000523:psychology* / Q000601:surgery; D008409:Mastication; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000150:complications / Q000523:psychology* / Q000532:radiotherapy; D010025:Osteoradionecrosis / Q000150:complications / Q000523:psychology* / Q000601:surgery; D010146:Pain / Q000209:etiology / Q000523:psychology / Q000601:surgery; D011788:Quality of Life / Q000523:psychology*; D019651:Plastic Surgery Procedures / Q000379:methods / Q000523:psychology; D012737:Sex Factors; D013064:Speech Disorders / Q000209:etiology / Q000523:psychology / Q000601:surgery; D013524:Surgical Flaps; D013651:Taste Disorders / Q000209:etiology / Q000523:psychology / Q000628:therapy; D014062:Tongue Neoplasms / Q000150:complications / Q000523:psychology / Q000532:radiotherapy; D016896:Treatment Outcome