Oligosaccharides from land plants and algae: production and applications in therapeutics and biotechnology.
Since the past decades, oligosaccharides are considered for their potential biological activities. To exploit them, it was essential to obtain pure molecules in large amounts. Several strategies were developed to produce specific sugar sequences with specific substitution patterns from land plants and algae polysaccharides. Then, pure oligosaccharides were analyzed for their potential biological activities and relations between oligomers structure and function were tackled. First they can be health beneficial molecules when they are added to the diet to enhance the growth of probiotic bacteria, in that case, oligomers that resist to the digestive process are used as specific substrate for the growth of health beneficial bacteria. In other cases, oligomers have to interact with receptors on cells. In this instance, a specific conformation is needed to allow the sugar sequence to establish specific linkages with the receptor. So, to be adapted to the receptor, the oligosaccharides have to present specific groups to the receptor, there, the polymerization degree of oligosaccharides as well as the flexibility of the glycosidic linkages has to be considered.
Courtois
Josiane
J
Laboratoire des Polysaccharides Microbiens et Végétaux, IUT/GB, Université de Picardie Jules Verne, Avenue des Facultés le Bailly, Amiens, France. Josiane.courtois@u-picardie.fr
D001709:Biotechnology / Q000379:methods*; D056890:Eukaryota / Q000737:chemistry*; D006801:Humans; D009844:Oligosaccharides / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D010944:Plants / Q000737:chemistry*; D013812:Therapeutics
D009844:Oligosaccharides