Persistence of high levels of blood soluble human leukocyte antigen-G is associated with rapid progression of HIV infection.
Human leukocyte antigen-G is an important suppressor of the immune response, and HIV can modulate its expression. Longitudinal monitoring of soluble human leukocyte antigen-G plasma levels in patients with primary HIV infection undergoing different rates of disease progression showed that levels were elevated in the early phases of infection and remained high throughout follow-up in rapid progressors who responded to antiretroviral therapy but were restored to normal levels in the chronic phase of infection in both untreated normal progressors and long-term nonprogressors.
Lajoie
Julie
J
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Québec, Canada.
Fontaine
Julie
J
Tremblay
Cécile
C
Routy
Jean-Pierre
JP
Poudrier
Johanne
J
Roger
Michel
M
D019380:Anti-HIV Agents / Q000627:therapeutic use; D004812:Epidemiologic Methods; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D015497:HIV-1; D006680:HLA Antigens / Q000097:blood*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D006801:Humans
D019380:Anti-HIV Agents; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I