SNAT1 and a family with high rates of suicidal behavior.
Several lines of evidence suggest that suicide may have, in part, a genetic predisposition. In this study, we identified a family with high rates of suicidal behavior and assessed brain gene expression levels in the proband. A neuronally-expressed solute carrier for glutamine (Sodium-coupled neutral amino acid transporter 1 (SNAT1), also known as solute carrier family 38, member 1 (SLC38A1)) was identified as severely decreased across all brain regions. Follow-up analysis by semi-quantitative polymerase chain reaction (qPCR) and Western blot confirmed the reduction of SNAT1. We categorized the SNAT1 gene in human brain, cloned the gene promoter and assessed in silico the expression pattern of SNAT1 in >25 tissues from human. Complete DNA sequencing of the SNAT1 gene was performed in the family and 276 controls. The family was homozygous for rare alleles which suggests a possible association between low expression of SNAT1 and suicidal behavior.
Ernst
C
C
McGill Group for Suicide Studies, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Montreal, QC, Canada H4H 1R3.
Dumoulin
P
P
Cabot
S
S
Erickson
J
J
Turecki
G
G
D000328:Adult; D026924:Amino Acid Transport System A / Q000096:biosynthesis / Q000235:genetics*; D001921:Brain / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D013405:Suicide / Q000523:psychology*
D026924:Amino Acid Transport System A; C445761:SLC38A1 protein, human