Efficacy of triazoles in a murine disseminated infection by Candida krusei.
We evaluated the efficacies of posaconazole and voriconazole in comparison with that of amphotericin B in a systemic murine infection by Candida krusei. Posaconazole at 50 mg/kg/day and voriconazole at 40 and 60 mg/kg/day prolonged survival and reduced the fungal tissue burden in the kidneys of mice similarly to amphotericin B at 1.5 mg/kg/day and liposomal amphotericin B at 10 mg/kg/day. None of the treatments tested completely resolved the infection.
Mariné
Marçal
M
Unitat de Microbiologia, Facultat de Medicina, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Spain.
Pastor
F Javier
FJ
Serena
Carolina
C
Guarro
Josep
J
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000502:physiology*; D002177:Candidiasis / Q000188:drug therapy* / Q000401:mortality; D007668:Kidney / Q000382:microbiology; D008297:Male; D051379:Mice; D011743:Pyrimidines / Q000627:therapeutic use; D011897:Random Allocation; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B; D065819:Voriconazole