Complement component 5a (C5a).
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert a number of effects essential to the innate immune response, while their actions at the more recently discovered non-G protein-coupled receptor, C5L2 (or GPR77), remain unclear. The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases, making C5a inhibition an attractive therapeutic strategy.
Manthey
Helga D
HD
School of Biomedical Sciences, University of Queensland, Brisbane, Australia. h.manthey@uq.edu.au
Woodruff
Trent M
TM
Taylor
Stephen M
SM
Monk
Peter N
PN
D000595:Amino Acid Sequence; D000818:Animals; D015936:Complement C5a / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data
D015936:Complement C5a