[Pleiotropic effects of leptin].
Leptin, also called the satiation hormone plays a key role in regulating body weight, energy intake, and expenditure. Leptin interacts with its receptors, mainly located in the hypothalamus. Moreover, there has been an increasing evidence that leptin exerts pleiotropic effects. Multiple peripheral effects of leptin have been recently described including synthesis of the various hormones, e.g., sexual hormones, thyroid hormones, and growth hormone, as well as regulation of blood pressure, reproduction, osteogenesis, hematopoesis, angiogenesis. Leptin also plays a regulatory function in immunity.and in the process of tumorigenesis. Despite intensive investigations since leptin discovery in 1994 we have much to learn about the leptin mechanism of actions and effects.
Górska
Elzbieta
E
Zakład Diagnostyki Laboratoryjnej i Immunologii Klinicznej Wieku Rozwojowego, Warszawski Uniwersytet Medyczny. elgorska@litewska.edu.pl
Popko
Katarzyna
K
Winiarska
Magdalena
M
Wasik
Maria
M
D000818:Animals; D001835:Body Weight / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology; D006728:Hormones / Q000096:biosynthesis; D006801:Humans; D020738:Leptin / Q000276:immunology / Q000378:metabolism*; D009369:Neoplasms / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000502:physiology; D054411:Receptors, Leptin / Q000378:metabolism
D006728:Hormones; D020738:Leptin; D054411:Receptors, Leptin