Extracts from Glycine max (soybean) induce elastin synthesis and inhibit elastase activity.
Elastic fibres are essential extracellular matrix components of the skin, contributing to its resilience and elasticity. In the course of skin ageing, elastin synthesis is reduced, and elastase activity is accelerated, resulting in skin sagging and reduced skin elasticity. Our studies show that non-denatured Glycine max (soybean) extracts induced elastin promoter activity, inhibited elastase activity and protected elastic fibres from degradation by exogenous elastases in vitro. Mouse and swine skins topically treated with soybean extracts showed enhanced elastic fibre network and increased desmosine content. Elastin expression was also augmented in human skin transplanted onto SCID mice in response to soy treatment. These data suggest that non-denatured soybean extracts may be used as skin care agents to reduce the signs of skin ageing.
Zhao
Renbin
R
Bruning
Elizabeth
E
Rossetti
Dianne
D
Starcher
Barry
B
Seiberg
Miri
M
Iotsova-Stone
Violetta
V
D000818:Animals; D002460:Cell Line; D024042:Collagen Type I / Q000235:genetics; D020405:Dermis / Q000378:metabolism; D003895:Desmosine / Q000032:analysis; D004547:Elastic Tissue / Q000378:metabolism; D004549:Elastin / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects / Q000235:genetics; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000494:pharmacology; D053508:Matrix Metalloproteinase 12 / Q000737:chemistry; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D008812:Mice, Hairless; D016513:Mice, SCID; D032446:Myoblasts / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011401:Promoter Regions, Genetic / Q000235:genetics; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D016038:Skin Transplantation; D030262:Soybean Proteins / Q000737:chemistry; D013025:Glycine max / Q000737:chemistry*; D013552:Swine; D014162:Transfection; D014333:Tropoelastin / Q000235:genetics
D024042:Collagen Type I; D016326:Extracellular Matrix Proteins; C492373:FBLN5 protein, human; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D030262:Soybean Proteins; D014333:Tropoelastin; D003895:Desmosine; D004549:Elastin; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; C507122:MMP12 protein, human; D053508:Matrix Metalloproteinase 12