CSF oligoclonal band patterns reveal disease heterogeneity in multiple sclerosis.
Oligoclonal IgG bands (OCGB) are characteristic of multiple sclerosis (MS). Most patients show OCGB exclusively in cerebrospinal fluid (CSF). Others have serum bands with additional ones in CSF. Moreover, IgM bands against myelin lipids (LS-OCMB) associate with aggressive relapsing-remitting MS (RRMS). We studied oligoclonal bands in 424 MS patients. Most primary progressive (PPMS) patients showed serum OCGB with additional bands in CSF. Conversely, most RRMS and secondary progressive (SPMS) patients showed OCGB exclusively in CSF (p<0.0001). Moreover, no PPMS patient presented LS-OCMB, while 31% of RRMS and 60% of SPMS groups showed these antibodies (p<0.0001). This suggests heterogeneous autoimmune mechanisms in MS.
Villar
Luisa M
LM
Departments of Neurology and Immunology, Ramón y Cajal Hospital, Madrid, Spain. lvillar.hrc@salud.madrid.org
Masterman
Thomas
T
Casanova
Bonaventura
B
Gómez-Rial
José
J
Espiño
Mercedes
M
Sádaba
María C
MC
González-Porqué
Pedro
P
Coret
Francisco
F
Alvarez-Cermeño
José C
JC
D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology; D043025:Oligoclonal Bands / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology
D001323:Autoantibodies; D043025:Oligoclonal Bands