[Effects of chronic fluoxetine treatment on catalepsy and immune response in mice genetically predisposed to freezing reaction: the role of 5-HT1A and 5-HT2A receptors and tph2 and SERT genes].
ASC/Icg (Antidepressant Sensitive Catalepsy) mouse strain selected for high predisposition to pinch-induced catalepsy is characterized by depressive-like behavior and impaired immune response. Chronic treatment with SSRI fluoxetine attenuated catalepsy manifestation and normalized a decreased number of rosette-forming cells (RFC) in spleen in ASC mice. Chronic fluoxetine administration had no effect on catalepsy and RFC number in mice of parental cataleptic CBA/Lac strain. Fluoxetine failed to alter 5-HT1A receptor functional activity in mice of both strains and diminished 5-HT2A receptor functional activity in CBA but not in ASC mice. No effect on cortical 5-HT1A and 5-HT2A receptor mRNA levels and on 5-HT1A receptor, tph2 (tryptophan hydroxylase-2) and SERT (serotonin transporter) mesencephalic gene expression was observed in ASC mice. Other possible serotonergic mechanisms of fluoxetine effect on catalepsy and immune response in mice with depressive-like state are discussed.
Tikhonova
M A
MA
Al'perina
E L
EL
Tolstikova
T G
TG
Bazovkina
D V
DV
Di
V Iu
VIu
Idova
G V
GV
Kulikov
A V
AV
Popova
N K
NK
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002375:Catalepsy / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D005473:Fluoxetine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D008297:Male; D051379:Mice; D044282:Receptor, Serotonin, 5-HT1A / Q000502:physiology*; D044402:Receptor, Serotonin, 5-HT2A / Q000502:physiology*; D012397:Rosette Formation; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity; D014365:Tryptophan Hydroxylase / Q000235:genetics / Q000502:physiology*
D000928:Antidepressive Agents; D044402:Receptor, Serotonin, 5-HT2A; D050486:Serotonin Plasma Membrane Transport Proteins; C493231:Slc6a4 protein, mouse; D005473:Fluoxetine; D044282:Receptor, Serotonin, 5-HT1A; C487802:Tph2 protein, mouse; D014365:Tryptophan Hydroxylase