title: Persistence of high levels of blood soluble human leukocyte antigen-G is associated with rapid progression of HIV infection.
abstract: Human leukocyte antigen-G is an important suppressor of the immune response, and HIV can modulate its expression. Longitudinal monitoring of soluble human leukocyte antigen-G plasma levels in patients with primary HIV infection undergoing different rates of disease progression showed that levels were elevated in the early phases of infection and remained high throughout follow-up in rapid progressors who responded to antiretroviral therapy but were restored to normal levels in the chronic phase of infection in both untreated normal progressors and long-term nonprogressors.
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Québec, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Lajoie
authors.forename: Julie
authors.initials: J
authors.lastname: Fontaine
authors.forename: Cécile
authors.initials: C
authors.lastname: Tremblay
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Routy
authors.forename: Johanne
authors.initials: J
authors.lastname: Poudrier
authors.forename: Michel
authors.initials: M
authors.lastname: Roger
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D004812:Epidemiologic Methods; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D015497:HIV-1; D006680:HLA Antigens / Q000097:blood*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D006801:Humans
chemical_list: D019380:Anti-HIV Agents; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I