Immunogenetics of drug-induced skin blistering disorders. Part II: synthesis.
The overall immunopathogenesis relevant to a large series of disorders caused by a drug or its associated hyperimmune condition is discussed based upon examining the genetics of severe drug-induced bullous skin problems (sporadic idiosyncratic adverse events including Stevens-Johnson syndrome and Toxic epidermal necrolysis). New results from an exemplar study on shared precipitating and perpetuating inner causes with other related disease phenotypes including aphtous stomatitis, Behçets, erythema multiforme, Hashimoto's thyroiditis, pemphigus, periodic fevers, Sweet's syndrome and drug-induced multisystem hypersensitivity are presented. A call for a collaborative, wider demographic profiling and deeper immunotyping in suggested future work is made.
Bowman
Clive
C
School of Biological Sciences, University of Reading, Whiteknights, Reading, UK. c.e.bowman@reading.ac.uk
Delrieu
Olivier
O
D001768:Blister / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D003580:Cytochromes / Q000235:genetics; D003710:Demography; D014644:Genetic Variation; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology; D055261:Immunogenetic Phenomena
D003580:Cytochromes; D006680:HLA Antigens; D015235:HLA-B Antigens; D015395:Histocompatibility Antigens Class I