title: Biocompatibility of a polymeric implant for the treatment of osteomyelitis.
abstract: We evaluated the biocompatibility of an injectable gelling polymeric device for the controlled release of gentamicin sulfate in the treatment of invasive bacterial infections in bone of male Wister rats. The biodegradable delivery carrier, poly(sebacic-co-ricinoleic-ester-anhydride), designated as p(SA:RA), was injected, with and without gentamicin, into the tibial canal. Rats were killed 3 weeks later. The tibiae were processed histologically, leaving the injectable polymer in situ. The local tissue reaction to the polymer with or without antibiotic consisted mainly of mild reactive fibroplasia/fibrosis and mild to moderate increased reactive bone formation. At this stage, no evidence for any active inflammatory response to the polymer was seen. Thus, the injection of p(SA:RA) was well tolerated and did not induce any signs of a progressive inflammatory reaction.
authors.affiliation: Department of Orthopaedic Surgery, Meir Medical Center, 48 Tchernichovsky Str., Kfar-Saba 44281, Israel. yaronbrin@gmail.com
authors.forename: Y S
authors.initials: YS
authors.lastname: Brin
authors.forename: A
authors.initials: A
authors.lastname: Nyska
authors.forename: A J
authors.initials: AJ
authors.lastname: Domb
authors.forename: J
authors.initials: J
authors.lastname: Golenser
authors.forename: B
authors.initials: B
authors.lastname: Mizrahi
authors.forename: M
authors.initials: M
authors.lastname: Nyska
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D007249:Inflammation / Q000139:chemically induced; D007267:Injections; D008297:Male; D008422:Materials Testing / Q000379:methods*; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D011108:Polymers / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers