Protective effect of reversible cholinesterase inhibitors (tacrine, pyridostigmine) and eqbuche against VX poisoning and brain acetylcholinesterase inhibition in rats.
The protective effect of the reversible cholinesterase inhibitors tacrine and pyridostigmine alone or in combination with different drugs against acetylcholinesterase inhibition in the pontomedullar area and cerebellum of rats caused by VX agent (O-ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate) in vivo (2xLD50) was studied along with survival of animals pretreated with different combinations of the drugs used. The best prophylactic effect was observed in a combination of pyridostigmine with benactyzine, trihexyphenidyle and HI-6. Tacrine alone or in other combinations has had no better prophylactic effect in comparison with these combinations containing pyridostigmine. Equine butyrylcholinesterase, also protected against VX poisoning very effectively.
Bajgar
Jirí
J
University of Defence, Faculty of Military Health Sciences, Department of Toxicology, Hradec Králové, Czech Republic. bajgar@pmfhk.cz
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use* / Q000633:toxicity*; D005260:Female; D020258:Neurotoxicity Syndromes / Q000517:prevention & control*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D011729:Pyridostigmine Bromide / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013619:Tacrine / Q000494:pharmacology
D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D011729:Pyridostigmine Bromide; D013619:Tacrine; C009680:VX-agent