title: Successful treatment of transplant-associated microangiopathy with rituximab.
abstract: The microangiopathic anaemia with thrombocytopenia--which can occur after haematopoietic stem cell transplant--resembles thrombotic thrombocytopenic purpura but has different pathophysiology and does not respond to plasma exchange. We describe a patient with severe manifestations of this disorder who recovered promptly following treatment with rituximab, an anti-CD20 antibody.
authors.forename: Helen
authors.initials: H
authors.lastname: Marr
authors.forename: Emma-Jane
authors.initials: EJ
authors.lastname: McDonald
authors.forename: Eileen
authors.initials: E
authors.lastname: Merriman
authors.forename: Mark
authors.initials: M
authors.lastname: Smith
authors.forename: Hilda
authors.initials: H
authors.lastname: Mangos
authors.forename: Catherine
authors.initials: C
authors.lastname: Stoddart
authors.forename: Peter
authors.initials: P
authors.lastname: Ganly
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000175:diagnosis / Q000601:surgery; D000743:Anemia, Hemolytic / Q000188:drug therapy* / Q000209:etiology*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D058846:Antibodies, Monoclonal, Murine-Derived; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011697:Purpura, Thrombotic Thrombocytopenic / Q000188:drug therapy / Q000209:etiology; D018570:Risk Assessment; D000069283:Rituximab; D012720:Severity of Illness Index; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab