Thyroid status can influence brain mast cell population.
Neuroanatomical mapping as well as the influence of thyroid status on brain mast cell distribution and detectable mast cell number in adult Rana esculenta is studied. Treatment with tizoxin (T4) does not modify number or activational state of brain mast cells, whereas administration of the antithyroid agent 6-n-propyl-2-thiouracil induces a significant increase (up to 40%) in the mast cell number within the telencephalon and diencephalon. Hypophysectomy induces a significant decrease (up to 65%) of mast cells in all brain regions, whereas the pituitary homogenate augments their number. The results suggest that the pituitary-thyroid axis may be involved in the regulation of brain mast cell population.
Baccari
Gabriella Chieffi
GC
Department of Life Sciences, Second University of Naples, Naples, Italy.
Monteforte
Rossella
R
Pinelli
Claudia
C
Santillo
Alessandra
A
Polese
Gianluca
G
Rastogi
Rakesh K
RK
D000818:Animals; D001921:Brain / Q000166:cytology* / Q000378:metabolism*; D002452:Cell Count; D008407:Mast Cells / Q000166:cytology* / Q000378:metabolism*; D011893:Rana esculenta / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism*