Characteristics and outcome of prostate cancer with PSA <4 ng/ml at diagnosis: a population-based study.
This population-based study aims to assess prognosis of prostate cancer diagnosed with prostate-specific antigen (PSA) levels <4 ng/ml in routine care. Materials and methods We compared prostate cancer patients with low PSA values (n=59) with other prostate cancer patients (n=1330) by logistic regression and the Cox model using data from the Geneva Cancer Registry. Results Patients with low PSA values more frequently had early-stage and well differentiated tumours. Nevertheless, 35% presented with aggressive tumour characteristics or metastases. After adjustment for other prognostic factors, prostate cancer-specific mortality was similar for both groups (hazard ratio: 1.1; 95%CI: 0.6-2.2). Conclusion We conclude that cancer with low PSA values at diagnosis is not indolent.
Bonet
M
M
Division of Radiation Oncology, Geneva University Hospitals, Geneva, Switzerland.
Merglen
A
A
Fioretta
G
G
Rapiti
E
E
Neyroud-Caspar
I
I
Zanetti
R
R
Miralbell
R
R
Bouchardy
C
C
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D016019:Survival Analysis
D017430:Prostate-Specific Antigen