title: Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study.
abstract: Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [-7400InDel, -6752AT (rs6676671), -3538AT (rs1800890), -1087AG (rs1800896), -597AC (rs1800872)] of the IL-10 5'-flanking region in a hospital-based case-control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with 162 healthy cancer-free Caucasian control participants from the same area matched by age. Using multivariate analysis for the number of nevi and skin type, the IL-10 'higher producing' haplotype ITAGC was found to be significantly associated with a reduced risk of developing melanoma (adjusted P=0.02). Although our findings need to be confirmed by independent and larger multicenter studies, we have described for the first time the association of distal gene variants of the IL-10 gene as an independent risk factor for melanoma.
authors.affiliation: Department of Hematology and Oncology, Georg-August University of Goettingen, Goettingen 37099, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Schoof
authors.forename: F
authors.initials: F
authors.lastname: von Bonin
authors.forename: I R
authors.initials: IR
authors.lastname: König
authors.forename: R
authors.initials: R
authors.lastname: Mössner
authors.forename: U
authors.initials: U
authors.lastname: Krüger
authors.forename: K
authors.initials: K
authors.lastname: Reich
authors.forename: C
authors.initials: C
authors.lastname: Berking
authors.forename: M
authors.initials: M
authors.lastname: Volkenandt
authors.forename: A
authors.initials: A
authors.lastname: Ziegler
authors.forename: L
authors.initials: L
authors.lastname: Böckmann
authors.forename: C
authors.initials: C
authors.lastname: Kuschal
authors.forename: K-M
authors.initials: KM
authors.lastname: Thoms
authors.forename: D
authors.initials: D
authors.lastname: Kube
authors.forename: S
authors.initials: S
authors.lastname: Emmert
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D016753:Interleukin-10