title: Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes.
abstract: Certain streptomycin resistance mutations (i.e., rpsL and rsmG) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental regulator gene, bldD, in the latter organism.
authors.affiliation: National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Mamoru
authors.initials: M
authors.lastname: Komatsu
authors.forename: Susumu
authors.initials: S
authors.lastname: Okamoto
authors.forename: Shinji
authors.initials: S
authors.lastname: Tokuyama
authors.forename: Akira
authors.initials: A
authors.lastname: Kaji
authors.forename: Haruo
authors.initials: H
authors.lastname: Ikeda
authors.forename: Kozo
authors.initials: K
authors.lastname: Ochi
mesh_terms: D019943:Amino Acid Substitution; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000096:biosynthesis; D016368:Frameshift Mutation; D050505:Mutant Proteins / Q000235:genetics; D020125:Mutation, Missense; D009840:Oligomycins / Q000096:biosynthesis; D012269:Ribosomal Proteins / Q000235:genetics*; D016930:Saccharopolyspora / Q000235:genetics* / Q000378:metabolism*; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D050505:Mutant Proteins; D009840:Oligomycins; D012269:Ribosomal Proteins; D004917:Erythromycin