[Protective effect of estrogen against chemotherapy-induced ovarian damage in rats].
OBJECTIVE
To investigate the protective effect of estrogen against cyclophosphamide (CTX)-induced ovarian failure in female rats.


METHODS
Sixty female Wistar rats (2-3 months old) were randomized into 4 groups to receive treatments with normal saline, CTX, estradiol (E2) or CTX+E2. Serum estradiol and follicle-stimulating hormone (FSH) concentrations were measured regularly in the 4 groups, and the weight of the ovary and uterus, follicle number and mean diameter of the follicles were compared.


RESULTS
Compared with CTX+EE2 group, the CTX group showed significantly increased FSH levels and decreased EE2 levels (P<0.05). The weight of the ovary and uterus and follicle number were significantly lower in CTX group than in CTX+EE2 group (P<0.05). No obvious differences in the indexes were found between the control and CTX+E2 groups.


CONCLUSIONS
Estrogen administration provides protection against CTX-induced ovarian damage in rats.
Han
Li-ping
LP
Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. hanliping.2006@yahoo.com.cn
He
Yuan-li
YL
D000818:Animals; D003520:Cyclophosphamide / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D010053:Ovary / Q000187:drug effects / Q000473:pathology*; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced* / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004958:Estradiol; D003520:Cyclophosphamide; D005640:Follicle Stimulating Hormone