Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid.
Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra.
Koch
Michael
M
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA.
Bugni
Tim S
TS
Pond
Chris D
CD
Sondossi
Mohammad
M
Dindi
Manah
M
Piskaut
Pius
P
Ireland
Chris M
CM
Barrows
Louis R
LR
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005591:Chemical Fractionation; D053280:Diynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029630:Santalaceae / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D053280:Diynes; D005231:Fatty Acids, Unsaturated; D010936:Plant Extracts; C547032:exocarpic acid