A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation.
Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stem cell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.
Oyama
Yu
Y
Department of Medicine, Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Burt
Richard K
RK
Thirkill
Charles
C
Hanna
Eissa
E
Merrill
Kevin
K
Keltner
John
J
D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D015153:Blotting, Western; D004596:Electroretinography; D005136:Eye Proteins / Q000276:immunology; D005260:Female; D006311:Hearing Disorders / Q000209:etiology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000276:immunology / Q000628:therapy*; D012164:Retinal Diseases / Q000276:immunology / Q000628:therapy*; D013577:Syndrome; D014182:Transplantation, Autologous; D014786:Vision Disorders / Q000209:etiology / Q000628:therapy; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields
D001323:Autoantibodies; D001324:Autoantigens; D005136:Eye Proteins