title: Myxobacteria--'microbial factories' for the production of bioactive secondary metabolites.
abstract: In this article, we briefly review the potential of myxobacteria as 'natural product factories' by highlighting results from the recently sequenced myxobacterial model strain Myxococcus xanthus. We will focus on the production of polyketides, non-ribosomally-made peptides, and their hybrids, and discuss the evaluation of biosynthetic potential using genome-based methods, as well as biosynthetic process engineering.
authors.affiliation: Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.
authors.forename: Silke C
authors.initials: SC
authors.lastname: Wenzel
authors.forename: Rolf
authors.initials: R
authors.lastname: Müller
mesh_terms: D053898:Biosynthetic Pathways; D034261:Epothilones / Q000096:biosynthesis / Q000737:chemistry; D015964:Gene Expression Regulation, Bacterial; D005818:Genetic Engineering; D007218:Industrial Microbiology / Q000379:methods*; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism; D009231:Myxococcales / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D016941:Myxococcus xanthus / Q000235:genetics / Q000378:metabolism
chemical_list: D034261:Epothilones; D018942:Macrolides