Indoles from simple anilines and alkynes: palladium-catalyzed C-H activation using dioxygen as the oxidant.
Pd doles it out: A palladium-catalyzed approach to indoles using the title reaction was achieved (see scheme). The oxidant used in this catalytic cycle was O(2). Both N-nonsubstituted and N-alkyl monosubstituted anilines can be successfully transformed into the corresponding indoles by this method.
Shi
Zhuangzhi
Z
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100083, China.
Zhang
Chun
C
Li
Si
S
Pan
Delin
D
Ding
Shengtao
S
Cui
Yuxin
Y
Jiao
Ning
N
D000480:Alkynes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000480:Alkynes; D000814:Aniline Compounds; D007211:Indoles; D016877:Oxidants; D010165:Palladium; D010100:Oxygen; C023650:aniline