Fully automated synthesis procedure of 4-[18F]fluorobenzaldehyde by commercial synthesizer: amino-oxi peptide labelling prosthetic group.
Automatic synthesis of 4-[18F]fluorobenzaldehyde has been developed by a commercially available TRACERlab FX(F-N) synthesis module to be used as prosthetic group for amino-oxy functionalized peptide labelling in clinical routine application. In addition a handmade purification device (HPD) has been setup to perform automatic cartridge purification as well as to back-up the reactor where one-pot synthesis is not applicable. Cartridges for solid phase extraction such as C18, C8, phenyl has been tested to best perform purification as well as activity recovery. Radiochemical yield (RCY) at end of synthesis (EOS) was in average 67% after about 45 min (90% decay corrected at EOB). The RCY of the entire procedure was 54% with a radiochemical purity above 99%.
Speranza
Antonio
A
IBB-CNR, Edificio 10, Via Pansini 5, Napoli, Italy. antonio.speranza@hotmail.com
Ortosecco
Giovanni
G
Castaldi
Elena
E
Nardelli
Anna
A
Pace
Leonardo
L
Salvatore
Marco
M
D001547:Benzaldehydes / Q000737:chemistry*; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling; D010455:Peptides / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry*
D001547:Benzaldehydes; D005462:Fluorine Radioisotopes; D010455:Peptides; D019275:Radiopharmaceuticals; C516422:4-fluorobenzaldehyde