title: Computed tomography perfusion in living donor liver transplantation: an initial study of normal hemodynamic changes in liver grafts.
abstract: Hepatic hemodynamic changes in grafts after living donor liver transplantation (LDLT) are complicated. In this study, computed tomography (CT) perfusion parameter values, especially portal vein perfusion (PVP), was retrospectively analyzed in recipients both with and without small-for-size syndrome (SFSS). PVP was significantly higher in non-SFSS recipients on post-operative day (POD) 14 or 28 than in normal donors before donation (p < 0.001 and p = 0.008, respectively), but it significantly decreased between 14 and 28 days post-operatively (p = 0.007). There was a significant inverse correlation between graft-to-recipient spleen size ratio and PVP on POD 14 in non-SFSS group (r = -0.545, p = 0.002). Furthermore, PVP in the SFSS group was significantly greater than in the non-SFSS group on POD 14 (p = 0.042). In conclusion, we successfully evaluated normal hemodynamic changes in grafts without SFSS by CT perfusion examination. To our knowledge, this is the first study on hemodynamic changes of living donor liver grafts using CT technique.
authors.affiliation: Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127 China.
authors.forename: Zhi Guo
authors.initials: ZG
authors.lastname: Zhuang
authors.forename: Li Jun
authors.initials: LJ
authors.lastname: Qian
authors.forename: Bi Xiong
authors.initials: BX
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Qi Gen
authors.initials: QG
authors.lastname: Li
authors.forename: Jian Rong
authors.initials: JR
authors.lastname: Xu
authors.forename: Yu Fan
authors.initials: YF
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006085:Graft Survival; D006439:Hemodynamics; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000000981:diagnostic imaging*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult