title: Assessment of endothelial function using digital pulse amplitude tonometry.
abstract: The importance of endothelial dysfunction in the development and clinical expression of cardiovascular disease is well recognized. Impaired endothelial function has been associated with an increased risk of cardiovascular events. Endothelial function may be evaluated in humans by assessing vasodilation in response to stimuli known to induce the release of nitric oxide. A novel pulse amplitude tonometry device noninvasively measures vasodilator function in the microcirculation of the finger. This article reviews the recent studies that support the utility of digital pulse amplitude tonometry as a relevant test of peripheral endothelial function.
authors.affiliation: Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. naomi.hamburg@bmc.org
authors.forename: Naomi M
authors.initials: NM
authors.lastname: Hamburg
authors.forename: Emelia J
authors.initials: EJ
authors.lastname: Benjamin
mesh_terms: D001916:Brachial Artery / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D008365:Manometry / Q000295:instrumentation* / Q000379:methods; D016491:Peripheral Vascular Diseases / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011674:Pulse