Dairy and industrial sources of trans fat do not impair peripheral insulin sensitivity in overweight women.
BACKGROUND
The 2 major dietary sources of trans fatty acids (TFAs) are partially hydrogenated oils and ruminant-derived products. Epidemiologic data suggest that chronic consumption of industrial sources of TFAs could be damaging to insulin sensitivity, but intervention studies on this issue have remained inconclusive.


OBJECTIVE
The trial was designed to compare the effects of dairy compared with industrial sources of TFAs on insulin sensitivity in overweight women.


METHODS
Sixty-three healthy women with abdominal obesity [waist circumference >88 cm and a body mass index (in kg/m(2)) >28] were recruited. After a run-in period, the volunteers were randomly assigned to consume 1 of 3 four-week diets: 60 g low-TFA lipids/d (0.54 g/d; n = 21), ruminant TFA-rich lipids (4.86 g/d; n = 21), or industrial TFA-rich lipids (5.58 g/d; n = 21). Changes in peripheral insulin sensitivity were assessed by using hyperinsulinemic-euglycemic clamps.


RESULTS
After the intervention period, fasting glycemia and insulinemia and insulin sensitivity were not significantly modified in either group (P > 0.05).


CONCLUSIONS
These data indicate that consumption of dairy- and industrial-source TFAs for 4 wk at nutritional levels do not impair peripheral insulin sensitivity in insulin-resistant women. Our study may not preassess the effects of TFAs in normal insulin-sensitive individuals. This trial was registered at ClinicalTrials.gov as NCT00617435.
Tardy
Anne-Laure
AL
From INRA, UMR 1019 Nutrition Humaine, Saint Genès Champanelle, France.
Lambert-Porcheron
Stéphanie
S
Malpuech-Brugère
Corinne
C
Giraudet
Christophe
C
Rigaudière
Jean-Paul
JP
Laillet
Brigitte
B
Leruyet
Pascale
P
Peyraud
Jean-Louis
JL
Boirie
Yves
Y
Laville
Martine
M
Michalski
Marie-Caroline
MC
Chardigny
Jean-Michel
JM
Morio
Béatrice
B
D000293:Adolescent; D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D003611:Dairy Products; D004041:Dietary Fats / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D006946:Hyperinsulinism; D007328:Insulin / Q000494:pharmacology*; D007333:Insulin Resistance / Q000502:physiology*; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000503:physiopathology*; D010349:Patient Compliance; D010743:Phospholipids / Q000097:blood; D012418:Ruminants; D044242:Trans Fatty Acids / Q000494:pharmacology*; D055105:Waist Circumference; D055815:Young Adult
D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D010743:Phospholipids; D044242:Trans Fatty Acids