title: Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus.
abstract: OBJECTIVE
  Although several experiments show that adiponectin is associated with bone metabolism, a relationship between adiponectin and bone markers is still unclear. We monitored chronological changes in hyperglycemia, serum adiponectin, and bone markers during glycemic control in type 2 diabetes and analyzed relationships among these parameters.
  
  
  RESULTS
  A total of 50 Japanese patients with poorly controlled type 2 diabetes [initial hemoglobin A(1c) (HbA(1c)) = 10.0 +/- 2.5%] were recruited, and biochemical data were collected before and after glycemic control for a month. Of bone formation markers, bone-specific alkaline phosphatase was decreased with a mean change of -3.11 [95% confidence interval (CI), -5.03 to -1.20; P < 0.01], whereas osteocalcin (OC) was increased with a mean change of 1.94 (95% CI, 1.45-2.42; P < 0.001) and undercarboxylated OC (ucOC)/OC ratio was decreased with a mean change of -0.15 (95% CI, -0.27 to -0.03; P < 0.01). Although adiponectin level was not significantly different before and after glycemic control, baseline adiponectin level, but not HbA(1c), was positively correlated with changes in OC, ucOC, and urinary N-terminal cross-linked telopeptide of type I collagen (uNTX) (r = 0.30, P =0.04; r = 0.32, P = 0.03; and r = 0.36, P = 0.01, respectively). Changes in adiponectin were also negatively correlated with changes in OC and uNTX (r = -0.42, P < 0.01; and r = -0.38, P < 0.01, respectively). Changes in HbA(1c) were negatively correlated with changes in OC (r = -0.30, P = 0.03).
  
  
  CONCLUSIONS
  These findings show that treatments for hyperglycemia enhance OC level and suggest that serum adiponectin level before starting to compensate poorly controlled diabetics could predict the subsequent improvement of bone remodeling markers during glycemic control.
authors.affiliation: Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Japan.
authors.forename: Ippei
authors.initials: I
authors.lastname: Kanazawa
authors.forename: Toru
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Mika
authors.initials: M
authors.lastname: Yamauchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Soichi
authors.initials: S
authors.lastname: Kurioka
authors.forename: Shozo
authors.initials: S
authors.lastname: Yano
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D001835:Body Weight; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000652:urine
chemical_list: D052242:Adiponectin; D000469:Alkaline Phosphatase; D001786:Blood Glucose; D024042:Collagen Type I; D005947:Glucose; D006442:Glycated Hemoglobin; D015675:Osteocalcin; D010455:Peptides; C499918:ADIPOQ protein, human; C052929:collagen type I trimeric cross-linked peptide; C517652:hemoglobin A1c protein, human