title: [Proton magnetic resonance spectroscopic imaging of the hippocampus in schizophrenia patients before and after surgery].
abstract: OBJECTIVE
  To explore the features of proton magnetic resonance spectroscopy (1H-MRS) of the hippocampus in schizophrenia patients before and after stereotactic neurosurgery.
  
  
  METHODS
  1H-MRS was performed to determine NAA/Cr and CHO/Cr ratios on the bilateral hippocampal regions before and after stereotactic neurosurgery in 20 schizophrenia patients, with 20 healthy individuals as the controls.
  
  
  RESULTS
  The NAA/Cr ratio in the hippocampal regions was significantly lower and the CHO/Cr ratio significantly higher in schizophrenia patients before the surgery than in the healthy controls (P<0.01). The NAA/Cr and CHO/Cr ratios in the hippocampal regions underwent no significant changes in the patients after the surgeries (P>0.05).
  
  
  CONCLUSIONS
  Neuronal and cell membrane metabolism impairment is present in the hippocampus of schizophrenia patients, and stereotactic neurosurgery does not produce obvious adverse effects on the cell membrane metabolism in the hippocampus of the patients.
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Hui-min
authors.initials: HM
authors.lastname: Chang
authors.forename: Song-tao
authors.initials: ST
authors.lastname: Qi
authors.forename: Kai-jun
authors.initials: KJ
authors.lastname: Yang
authors.forename: Ke-wan
authors.initials: KW
authors.lastname: Wang
authors.forename: Zhi-wan
authors.initials: ZW
authors.lastname: Guo
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D016022:Case-Control Studies; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D011522:Protons; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D013238:Stereotaxic Techniques; D055815:Young Adult
chemical_list: D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline