Voltammetric oxidation and determination of cinnarizine at glassy carbon electrode modified with multi-walled carbon nanotubes.
The voltammetric oxidation of cinnarizine was investigated. In pH 2.5 Britton-Robinson buffer, cinnarizine shows an irreversible oxidation peak at about 1.20 V at a multi-walled carbon nanotube (MWCNT)-modified glassy carbon electrode. The cyclic voltammetric results indicate that MWCNT-modified glassy carbon electrode can remarkably enhance electrocatalytic activity towards the oxidation of cinnarizine. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the cinnarizine determination by differential-pulse voltammetry. Under optimized conditions, the concentration range and detection limit are 9.0x10(-8) to 6.0x10(-6) M and 2.58x10(-9) M, respectively for cinnarizine. The proposed method was successfully applied to cinnarizine determination in pharmaceutical samples. The analytical performance of this sensor has been evaluated for the detection of analyte in urine as a real sample.
Hegde
Rajesh N
RN
P.G. Department of Studies in Chemistry, Karnatak University, Dharwad-580 003, India.
Hosamani
Ragunatharaddi R
RR
Nandibewoor
Sharanappa T
ST
D002936:Cinnarizine / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D036103:Nanotechnology / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction
D037742:Nanotubes, Carbon; D002936:Cinnarizine