[Safety and efficacy of intraoperative 5-fluorouracil infiltration in pterygium treatment].
OBJECTIVE
To investigate the safety and efficacy of intraoperative infiltration of 5-fluorouracil (5-FU) as an adjuvant drug in pterygium treatment.


METHODS
Of 125 consecutive patients, 125 eyes with primary and recurrent pterygium underwent pterygium excision with intraoperative 5-FU (25 mg/mL) infiltration. The superior and inferior conjunctiva was approximated to cover the scleral bed and 0.2 mL 5-FU was injected at the end of the surgical procedure. The gender, occupation, pterygium characteristics and the follow-up at 7, 21, 60 e 180 days after surgery were evaluated and the data were statistically analyzed.


RESULTS
With follow-up of 180 days the patients had no serious complications observed during or after surgery. The relapse rate was 35.8% and occurred in primary (35.7%) and recurrent (36.4%) lesions with no statistical difference.


CONCLUSIONS
This study suggests that intraoperative infiltration of 5-FU is safe. However the high recurrence rate indicated that other studies would be necessary to show the concentration/dose to better prevent it.
Valezi
Vanessa Grandi
VG
Departamento de Oftalmologia/Otorrinolaringologia/Cabeça e Pescoço, Universidade Estadual Paulista, Botucatu, SP, Brasil. sartioli@fmb.unesp.br
Schellini
Silvana Artioli
SA
Viveiros
Magda Massae Hata
MM
Padovani
Carlos Roberto
CR
D000328:Adult; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011625:Pterygium / Q000188:drug therapy / Q000601:surgery*; D055502:Secondary Prevention; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D005472:Fluorouracil