title: Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid.
abstract: Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra.
authors.affiliation: Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Koch
authors.forename: Tim S
authors.initials: TS
authors.lastname: Bugni
authors.forename: Chris D
authors.initials: CD
authors.lastname: Pond
authors.forename: Mohammad
authors.initials: M
authors.lastname: Sondossi
authors.forename: Manah
authors.initials: M
authors.lastname: Dindi
authors.forename: Pius
authors.initials: P
authors.lastname: Piskaut
authors.forename: Chris M
authors.initials: CM
authors.lastname: Ireland
authors.forename: Louis R
authors.initials: LR
authors.lastname: Barrows
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005591:Chemical Fractionation; D053280:Diynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029630:Santalaceae / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D053280:Diynes; D005231:Fatty Acids, Unsaturated; D010936:Plant Extracts; C547032:exocarpic acid