Pediatric acute lymphoblastic leukemia complicated by secondary hemophagocytic lymphohistiocytosis.
Hemophagocytic lymphohistiocytosis (HLH) may be familial or secondary to infections, malignancies, metabolic disorders. Infectious causes are mostly viral and EBV is the mostly frequently seen etiologic agent. In this case, we report a child with acute lymphoblastic leukemia (ALL), who had three episodes of secondary HLH, possibly due to two different viral etiologies, namely CMV and RSV together with her malignancy, during her induction-consolidation treatment.
Devecioglu
Omer
O
Department of Pediatric Hematology/Oncology/BMT, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
Anak
Sema
S
Atay
Didem
D
Aktan
Pinar
P
Devecioglu
Esra
E
Ozalp
Beril
B
Saribeyoglu
Ebru
E
D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D018357:Respiratory Syncytial Virus Infections / Q000150:complications