title: Absolute stereostructures of chaetomugilins G and H produced by a marine-fish-derived Chaetomium species.
abstract: Chaetomugilins G and H were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish, Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and chemical transformation. In addition, the absolute configuration of chaetoviridin C was established by derivatization from chaetomugilin A. These compounds exhibited a growth inhibitory activity against cultured P388, HL-60, L1210 and KB cells.
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Nasahara 4-20-1, Takatsuki, Osaka, Japan. yamada@gly.oups.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Muroga
authors.initials: M
authors.lastname: Yasuhide
authors.forename: Hirohumi
authors.initials: H
authors.lastname: Shigeta
authors.forename: Atsushi
authors.initials: A
authors.lastname: Numata
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D045744:Cell Line, Tumor; D002597:Chaetomium / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D005399:Fishes / Q000382:microbiology*; D005663:Furans / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011753:Pyrones / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000903:Antibiotics, Antineoplastic; D005663:Furans; D011753:Pyrones; C544341:chaetomugilin G; C544342:chaetomugilin H