The relationship between gastroesophageal reflux disease and sleep.
Recent studies demonstrate a bidirectional relationship between gastroesophageal reflux disease (GERD) and sleep in which nighttime reflux leads to sleep deprivation and sleep deprivation can exacerbate GERD by enhancing perception of intraesophageal stimuli. Current treatment primarily focuses on reducing nighttime reflux, thus improving sleep quality. Future studies are needed to further explore the relationship between GERD and sleep and the potential of novel therapeutic options to interrupt the vicious cycle between them.
Fass
Ronnie
R
Southern Arizona VA Health Care System, GI Section (1-111-GI), Tucson, AZ 85723, USA. Ronnie.Fass@va.gov
D002940:Circadian Rhythm / Q000502:physiology; D018450:Disease Progression; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D012307:Risk Factors; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000150:complications* / Q000503:physiopathology