title: Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy.
abstract: To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and after RT for LC. LC patients had higher baseline serum urate, plasma nitrite and lower serum oxidized proteins than controls (p=0.016, p<0.001 and p=0.027, respectively), but BAL fluid oxidative stress markers were similar. RT tended to raise some antioxidants, however, significant increases were seen in serum urate, conjugated dienes and TBARS (p=0.044, p=0.034 and p=0.004, respectively) 3 months after RT. High urate at baseline may compensate against the oxidative stress caused by LC. RT shifts the oxidant/antioxidant balance towards lipid peroxidation, although the antioxidant defense mechanisms of the body appear to counteract the increased oxidative stress rather effectively.
authors.affiliation: Department of Oncology, University of Tampere, Tampere, Finland. macro1@sci.fi
authors.forename: Marika
authors.initials: M
authors.lastname: Crohns
authors.forename: Seppo
authors.initials: S
authors.lastname: Saarelainen
authors.forename: Hannu
authors.initials: H
authors.lastname: Kankaanranta
authors.forename: Eeva
authors.initials: E
authors.lastname: Moilanen
authors.forename: Hannu
authors.initials: H
authors.lastname: Alho
authors.forename: Pirkko
authors.initials: P
authors.lastname: Kellokumpu-Lehtinen
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000532:radiotherapy / Q000556:secondary; D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000378:metabolism / Q000532:radiotherapy / Q000556:secondary; D009573:Nitrites / Q000097:blood; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress; D055752:Small Cell Lung Carcinoma / Q000378:metabolism / Q000532:radiotherapy / Q000556:secondary; D015996:Survival Rate; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D009573:Nitrites; D016877:Oxidants; D017392:Thiobarbituric Acid Reactive Substances; D014527:Uric Acid