title: A preliminary association study between brain-derived neurotrophic factor (BDNF) haplotype and late-onset depression in mainland Chinese.
abstract: OBJECTIVE
  The present study aimed to assess the association of genotypes and haplotypes in brain-derived neurotrophic factor (BDNF) polymorphisms with late-onset depression (LOD) in a Chinese Han population.
  
  
  METHODS
  144 subjects with LOD and 110 control subjects were recruited for the study, assessed using the Hamilton Rating Scale for Depression, and genotyped for 712G/A, 270C/T, 196A/G and 11757G/C variants by polymerase chain reaction.
  
  
  RESULTS
  No differences were found in the frequencies of the alleles and genotypes of tested BDNF gene between LOD patients and normal group. Interestingly, the distributions of 712G-270T, 196A-11757G, 196G-11757C, 712G-196A-11757G, 712G-196G-11757C, 270C-196A-11757G, 270C-196G-11757C, 712G-270C-196A-11757G, 712G-270C-196G-11757C haplotypes were significantly higher in LOD compared to healthy controls (all P<0.05).
  
  
  CONCLUSIONS
  The results tentatively suggest that BDNF haplotypes might be the susceptibility for LOD.
authors.affiliation: Department of Psychiatry, Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Jiayong
authors.initials: J
authors.lastname: You
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Zhang
authors.forename: Hailin
authors.initials: H
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Qian
mesh_terms: D017668:Age of Onset; D000368:Aged; D044466:Asian People / Q000523:psychology* / Q000706:statistics & numerical data*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002681:China / Q000453:epidemiology; D017931:DNA Primers / Q000235:genetics; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D016133:Polymerase Chain Reaction; D011795:Surveys and Questionnaires
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D017931:DNA Primers