Influenza A virus TRIMs the type I interferon response.
The virulence of many pathogenic viruses depends on suppression of the innate type I interferon defense. For influenza viruses, a unique strategy has now been unraveled, as the viral nonstructural protein 1 was shown to inhibit activation of the pathogen recognition receptor RIG-I by binding the ubiquitin ligase TRIM25.
Ludwig
Stephan
S
Wolff
Thorsten
T
D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology* / Q000821:virology; D007370:Interferon Type I / Q000276:immunology*; D011485:Protein Binding; D014157:Transcription Factors / Q000276:immunology*; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases / Q000276:immunology*; D017361:Viral Nonstructural Proteins / Q000276:immunology*
C085820:INS1 protein, influenza virus; D007370:Interferon Type I; D014157:Transcription Factors; D000070584:Tripartite Motif Proteins; D017361:Viral Nonstructural Proteins; C084523:TRIM25 protein, human; D044767:Ubiquitin-Protein Ligases