title: Evaluation of a new hemostatic agent Ankaferd Blood Stopper in experimental liver laceration.
abstract: BACKGROUND
  Hemorrhage is a leading cause of death after trauma. It is also the major cause of operating room deaths among patients who undergo liver surgery. Various techniques and materials have been attempted to manage bleeding, but a standard method has not been defined yet. We studied the hemostatic effects of Ankaferd Blood Stopper on liver injury in comparison with regenerated oxidized cellulose.
  
  
  METHODS
  Thirty Wistar albino rats underwent partial hepatic laceration by scissors. The animals were randomized to the treatment of resected surface with either Ankaferd Blood Stopper (ABS, n = 11) or regenerated oxidized cellulose (Surgicel, n = 9), or were left untreated (controls, n = 10). All the animals were resuscitated with lactated Ringer's solution at 3.3 ml/min/kg to a mean arterial pressure (MAP) of 100 mmHg. Survival time, total blood loss, resuscitation volume, and MAP were recorded for 30 min or until death. The rats that were alive at the end of 30 min were sacrificed with blood withdrawal from catheters.
  
  
  RESULTS
  Rats in the ABS and Surgicel groups survived significantly longer than rats in the control group (p =.0001). There were no significant differences between the ABS and the Surgicel groups in survival (p =.91). Application of ABS and Surgicel was associated with a significant reduction in blood loss compared to controls (p =.008), with no significant differences between active treatment groups (p =.74). The resuscitation volume was not different.
  
  
  CONCLUSIONS
  ABS is as effective as Surgicel in achieving hemostasis following partial liver excision in an experimental rat model.
authors.affiliation: Department of General Surgery, Zonguldak Karaelmas University, Kozlu-Zonguldak, Turkey. knkarakaya@gmail.com
authors.forename: Kemal
authors.initials: K
authors.lastname: Karakaya
authors.forename: Hamdi B
authors.initials: HB
authors.lastname: Ucan
authors.forename: Oge
authors.initials: O
authors.lastname: Tascilar
authors.forename: Ali U
authors.initials: AU
authors.lastname: Emre
authors.forename: Guldeniz K
authors.initials: GK
authors.lastname: Cakmak
authors.forename: Oktay
authors.initials: O
authors.lastname: Irkorucu
authors.forename: Handan
authors.initials: H
authors.lastname: Ankarali
authors.forename: Mustafa
authors.initials: M
authors.lastname: Comert
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002483:Cellulose, Oxidized / Q000008:administration & dosage / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use*; D007022:Hypotension / Q000209:etiology; D022125:Lacerations / Q000150:complications*; D008099:Liver / Q000293:injuries*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012151:Resuscitation
chemical_list: D002483:Cellulose, Oxidized; D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper; C013695:Surgicel