[Influences of primary and repeated modeling of microgravity effects on spinal motoneurons l5 in rats: cytological analysis].
The cytochrome oxidase activity, sizes of bodies, nuclei, and nucleoli of alpha-motoneurons from the L5 anterior horns were investigated in rats once or repeatedly suspended by tails to model the effects of microgravity. Rats were suspended 30 days, then held in vivarium 30 days w/o any behavior restriction and suspended once again 14 days simultaneously with rats that had not been suspended before. The first-time 14-d suspension reduced the cytochrome oxidase activity as well as sizes of bodies and nuclei in alpha-motoneurons which pointed to hypofunctioning of these nervous cells. Repeated (14-d) suspension after the 30-day maintenance in vivarium decreased the alpha-motoneurons parameters much less significantly implying mild hypofunction and a faster adaptation of L5 alpha-motoneurons to microgravity modeled again after a long period of recess.
Krasnov
I B
IB
Krasnikov
G V
GV
Burtseva
T D
TD
Piskareva
G M
GM
Chel'naia
N A
NA
D000818:Animals; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D019417:Hindlimb Suspension / Q000379:methods; D008297:Male; D009046:Motor Neurons / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013127:Spinal Nerves / Q000473:pathology* / Q000503:physiopathology; D014893:Weightlessness / Q000009:adverse effects*; D018474:Weightlessness Simulation