title: Desymmetrization of hydrazinocyclohexadienes: a new approach for the synthesis of polyhydroxylated aminocyclohexanes.
abstract: Hydrazinocyclohexadienes, easily prepared by an ene-reaction between commercially available azodicarboxylate reagents and cyclohexadiene, are interesting substrates for desymmetrization reactions. Under Sharpless asymmetric dihydroxylation conditions, they can lead efficiently to several chiral building blocks as well as advanced precursors of biologically active compounds.
authors.affiliation: Laboratoire de Chimie Thérapeutique, UMR 8638 associée au CNRS et à l'Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 av de l'Observatoire, 75270 Paris cedex 06, France.
authors.forename: Gauthier
authors.initials: G
authors.lastname: Errasti
authors.forename: Cyrille
authors.initials: C
authors.lastname: Koundé
authors.forename: Olivier
authors.initials: O
authors.lastname: Mirguet
authors.forename: Thomas
authors.initials: T
authors.lastname: Lecourt
authors.forename: Laurent
authors.initials: L
authors.lastname: Micouin
mesh_terms: D002384:Catalysis; D003510:Cyclohexanes / Q000138:chemical synthesis* / Q000737:chemistry; D053138:Cyclohexenes / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D003510:Cyclohexanes; D053138:Cyclohexenes; D006834:Hydrazines; C048401:1,4-cyclohexadiene