[Viral and host causes of hepatosteatosis in Chinese patients with chronic hepatitis B].
OBJECTIVE
To explore the viral and host causes of hepatosteatosis in Chinese patient with chronic hepatitis B.


METHODS
A total of 562 patients (450 males and 112 females, age range 13-80 years) with biopsy-proven chronic hepatitis B were enrolled in the study. The patients were divided into two groups: group without steatosis (460 patients) and group with steatosis (102 patients). The groups were compared in terms of age, gender, body mass index (BMI), liver enzymes, cholesterol, triglyceride, APO-A, APO-B, urine acid (UA), fasting serum glucose (FSG) and HBeAg, viral load.


RESULTS
Steatosis was present in 102 patients (18.15%). The degree of liver steatosis in 97 (95.10%) patients were less 30%. Steatosis was found in 98 (21.78%) of male patients and 4 (3.75%) of female patients (P < 0.01). In the group of chronic hepatitis B with steatosis, the prevalence of obesity, diabetes mellitus, dyslipidaemia, alcoholic consumption, the BMI, cholesterol, triglyceride, UA and FSG levels were significantly higher than those in the group without steatosis (P < 0.01). No significant difference was found in the mean age, HBeAg, viral load between the two groups (P > 0.05). Logistic regression analysis demonstrated that the present of steatosis was positively correlated to BMI, TG and UA.


CONCLUSIONS
Hepatosteatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses.
Shi
Jun-ping
JP
Hangzhou Sixth People's Hospital, Hangzhou 310014, China.
Fan
Jian-gao
JG
Wu
Rui
R
Gao
Xiao-qian
XQ
Zhang
Li
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D005234:Fatty Liver / Q000150:complications* / Q000235:genetics / Q000473:pathology / Q000821:virology; D005260:Female; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence