Extensive apoptosis in a case of intractable infantile status epilepticus.
A previously healthy 8 1/2-month-old girl underwent epilepsy surgery for intractable focal seizures with secondary generalization that progressed to status epilepticus. The major neuropathologic finding was extensive apoptosis. Investigations did not reveal any etiology for the apoptosis or the seizures. This is the first report of apoptosis, without necrosis, in association with intractable status epilepticus in the developing human brain. The findings suggest that new treatment strategies targeted to prevent apoptosis may be useful in children with prolonged status epilepticus.
Cherian
Koshi A
KA
Saul R. Korey Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, United States. Kcherian@montefiore.org
Weidenheim
Karen
K
Legatt
Alan D
AD
Shifteh
Keivan
K
Abbott
I Richmond
IR
Moshé
Solomon L
SL
D000927:Anticonvulsants / Q000627:therapeutic use; D017209:Apoptosis / Q000502:physiology*; D001921:Brain / Q000473:pathology; D004351:Drug Resistance; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D013226:Status Epilepticus / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery
D000927:Anticonvulsants