title: Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum.
abstract: Two new Lycopodium alkaloids, serratezomines D (1) and E (2), were isolated from the club moss Lycopodium serratum var. serratum. Serratezomine D (1) is a new lucidine-type alkaloid, while serratezomine E (2) is a new phlegmarane-type alkaloid. The structures and relative stereochemistry of 1 and 2 were elucidated on the basis of spectroscopic data. Serratezomine D (1) exhibited an inhibitory activity against acetylcholinesterase.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yahata
authors.forename: Sunao
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hayashi
authors.forename: Toshiro
authors.initials: T
authors.lastname: Shibata
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D032502:Lycopodium / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D006574:Heterocyclic Compounds, 2-Ring; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; D011804:Quinolines; C542897:serratezomine D; C542896:serratezomine E; D000110:Acetylcholinesterase