Recent advances in 17beta-hydroxysteroid dehydrogenases.
The metabolism of steroids at position 17 is catalysed by a growing number of 17beta-hydroxysteroid dehydrogenases (17beta-HSDs). Several human diseases like breast or prostate cancer, endometriosis,metabolic syndrome and mental diseases were associated with dysfunctions of 17beta-HSDs, which consequently became drug targets. This review will focus on identities of 17beta-HSDs and recent advances in analyses of their physiological roles in steroid and lipid metabolism. It will also address the potential of metabolomics in drug development.
Prehn
Cornelia
C
Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany.
Möller
Gabriele
G
Adamski
Jerzy
J
D015067:17-Hydroxysteroid Dehydrogenases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D015195:Drug Design; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D050356:Lipid Metabolism; D055432:Metabolomics; D015394:Molecular Structure; D013256:Steroids / Q000737:chemistry / Q000378:metabolism*
D007527:Isoenzymes; D013256:Steroids; D015067:17-Hydroxysteroid Dehydrogenases