Development and persistence of posttraumatic stress disorder and the 5-HTTLPR polymorphism.
Association between 5-HTTLPR polymorphism and development of acute and persistence of chronic posttraumatic stress disorder (PTSD) was prospectively investigated. DNA was extracted from 41 motor-vehicle accident victims evaluated for development and persistence of PTSD, 1 and 12 months posttrauma. At Time 1, a nonsignificant trend for higher acute PTSD rate in ll homozygotes (82%) was observed compared to those with ss and sl genotypes (50%). At Time 2, higher chronic PTSD rate was found in ll homozygotes (55%) compared to those with ss and sl genotypes (20%), with an odds ratio of 4.8 (95% CI = 1.09-21.22). Contrary to previous findings, these data are suggestive of a protective role for the s allele of 5-HTTLPR in chronic PTSD.
Thakur
Geeta A
GA
Douglas Mental Health University Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Joober
Ridha
R
Brunet
Alain
A
D000063:Accidents, Traffic / Q000523:psychology; D000328:Adult; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology / Q000235:genetics*
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins