Electrometric assessment of the effect of a zinc oxide paste in diaper dermatitis.
Diaper dermatitis affects nearly 50% of infants as well as some bed-ridden adults particularly in the elderly people. This condition is induced by irritation and maceration, and may be further exacerbated by Candida sp. colonization and infection. A key factor in the pathogenesis is the alteration in both the barrier function and the water-holding capacity of the stratum corneum. The purpose of this study was to assess the effects of an unmedicated zinc oxide-petrolatum paste and to observe for possible shielding and restoring effects on the water-holding capacity of the stratum corneum altered by diaper dermatitis. The paste appeared to load the hollow skin microrelief. It was inferred that this effect was responsible for a reticulated shielding effect. Compared with healthy skin and untreated diaper dermatitis, the application of the anhydrous paste resulted in a trend to normalize electrometric properties of skin reflecting the combination of transepidermal water loss and the water-holding capacity of the stratum corneum.
Xhauflaire-Uhoda
E
E
Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liège, Liège, Belgium.
Henry
F
F
Piérard-Franchimont
C
C
Piérard
G E
GE
D000287:Administration, Topical; D000328:Adult; D003963:Diaper Rash / Q000188:drug therapy*; D017097:Electric Impedance; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010577:Petrolatum / Q000008:administration & dosage; D012879:Skin Physiological Phenomena / Q000187:drug effects; D015034:Zinc Oxide / Q000008:administration & dosage*
D010577:Petrolatum; D015034:Zinc Oxide