Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis.
OBJECTIVE
To characterize the differences in various risk factors for atherosclerosis between individuals with apoB higher (H) and lower (L) than predicted from regression equation apoB vs LDL-C.


METHODS
We evaluated 391 dyslipidemic subjects not treated with hypolipidemic drugs. The measured parameters included lipid profile, apolipoproteins A-1 and B, markers of insulin resistance and inflammation/hemostasis.


RESULTS
Correlation coefficient between apoB and LDL-C was 0.9 (p<0.0001). Individuals with H apoB compared to L apoB had significantly higher sex and age adjusted BMI, waist circumference, insulin, HOMA (fasting insulinglucose/22.5), C-peptide, proinsulin, PAI-1, sICAM-1, sVCAM-1, t-PA, vWF, frequency of metabolic syndrome and lower values of TC, LDL-C and HDL-C (p<0.05 to <0.001 for all parameters).


CONCLUSIONS
Individuals with apoB higher than predicted by their LDL-C levels are more insulin resistant and have more atherogenic risk profile. Thus, at least for dyslipidemic patients with high cardiometabolic risk, apoB is a more appropriate marker of risk than LDL-C.
Vaverkova
Helena
H
3rd Department of Internal Medicine, University Hospital Olomouc, Czech Republic. helena.vaverkova@fnol.cz
Karasek
David
D
Novotny
Dalibor
D
Jackuliakova
Dagmar
D
Lukes
Jiri
J
Halenka
Milan
M
Frohlich
Jiri
J
D000328:Adult; D001055:Apolipoproteins B / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D008875:Middle Aged; D012307:Risk Factors; D013223:Statistics as Topic
D001055:Apolipoproteins B; D015415:Biomarkers; D008078:Cholesterol, LDL