title: Atrophic change of tongue papilla in 44 patients with Sjögren syndrome.
abstract: OBJECTIVE
  The purpose of this study was to investigate the atrophic change of tongue papilla in Sjögren syndrome (SjS) patients and the correlation with characteristic features of the disease.
  
  
  METHODS
  Atrophic change of tongue papilla, investigated by a digital microscope, was classified from score 0 (normal) to score 6 (severe) and compared among 44 SjS patients, 20 xerostomia patients, and 20 healthy subjects. In SjS patients, correlation of the atrophic score of tongue papilla with characteristic changes in sialometry, sialography, lip biopsy, and serologic tests was also investigated.
  
  
  RESULTS
  The atrophic score of tongue papilla was significantly higher in SjS patients and correlated with the decrease of salivary secretion, the stage on sialography, and the histologic grade of the minor salivary gland.
  
  
  CONCLUSIONS
  Atrophic change of tongue papilla is significant in SjS patients and is correlated with the characteristic features of the disease.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan. kazuyama@naramed-u.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Miyako
authors.initials: M
authors.lastname: Kurihara
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Matsusue
authors.forename: Yuko
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Motokatsu
authors.initials: M
authors.lastname: Tsuyuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Shinobu
authors.initials: S
authors.lastname: Nakamura
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Kirita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012472:Salivation / Q000502:physiology; D012796:Sialography; D012859:Sjogren's Syndrome / Q000473:pathology*; D013650:Taste Buds / Q000473:pathology; D014059:Tongue / Q000473:pathology*; D014987:Xerostomia / Q000473:pathology*