title: Host-specificity of Salmonella enterica serovar Gallinarum: insights from comparative genomics.
abstract: In this study, we have identified the possible genetic factors responsible for fowl-adaptation of Salmonella entericaserovar Gallinarum (S. Gallinarum). By comparing the genes related to Salmonella pathogenicity islands (SPI) of S. Gallinarum with those of Salmonella entericaserovar Enteritidis (S. Enteritidis) we have identified twenty-four positively selected genes. Our results suggest that the genes encoding the structural components of SPI-2 encoded type three secretion apparatus (TTSS) and the effector proteins that are secreted via SPI-1 encoded TTSS have evolved under positive selection pressure in these serovars. We propose that these positively selected genes play important roles in conferring different host-specificities to S. Gallinarum and S. Enteritidis.
authors.affiliation: Department of Microbiology and Cell Biology, Centre for Infectious Disease Research and Biosafety Laboratories, Indian Institute of Science, Bangalore, Karnataka, India.
authors.forename: Sandeepa M
authors.initials: SM
authors.lastname: Eswarappa
authors.forename: Jessin
authors.initials: J
authors.lastname: Janice
authors.forename: Sudhagar V
authors.initials: SV
authors.lastname: Balasundaram
authors.forename: Narendra M
authors.initials: NM
authors.lastname: Dixit
authors.forename: Dipshikha
authors.initials: D
authors.lastname: Chakravortty
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D001715:Bird Diseases / Q000382:microbiology; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D044404:Genomic Islands / Q000235:genetics*; D023281:Genomics; D054884:Host-Pathogen Interactions / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics; D008957:Models, Genetic; D012481:Salmonella Infections, Animal / Q000382:microbiology; D019779:Salmonella enterica / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D012477:Salmonella enteritidis / Q000235:genetics / Q000472:pathogenicity; D012641:Selection, Genetic; D013045:Species Specificity
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; C440638:SPI-2 protein, Salmonella; C419942:Spi1 protein, Salmonella