[Total non-elastic pulmonary resistance and permeability of the alveolar capillary membrane in community-acquired pneumonia].
OBJECTIVE
To study alveolar capillary membrane permeability (ACMP) and total non-elastic pulmonary resistance (TNPR) in patients with community-acquired pneumonia (CAP) in an acute period.


METHODS
ACMP of the lungs was studied in 35 CAP patients with ventilation pulmonoscintigraphy. Integral and regional TNPR were registered at inhalation and expiration. Integral TNPR was estimated by simultaneous registration of transpulmonal pressure and spirogram, regional TNPR (in the upper, middle and lower zones of the lungs)--by simultaneous registration of zonal rheograms of ventilation and transpulmonal pressure. Bronchial resistance was measured by body plethismograph (Masterlab pro, Erich Jaeger, Germany).


RESULTS
In acute CAP integral TNPR rose while regional values varied. Both integral and regional ACMP for affected and intact lungs were significantly elevated showing systemic impairment of the structures of alveolar-capillary membrane of the lungs. More severe alterations of integral ACMP were seen in the affected lung, of regional--in the affected zones.


CONCLUSIONS
Changes registered in regional TNPR and ACMP may indicate enhanced mechanical activity of the lungs in these zones. This enhanced activity contributes to TNPR overcoming.
Tetenev
F F
FF
Ageeva
T S
TS
Krivonogov
N G
NG
Levchenko
A V
AV
Kashuta
A Iu
AIu
Tetenev
K F
KF
D000293:Adolescent; D000328:Adult; D002199:Capillary Permeability; D002200:Capillary Resistance; D006801:Humans; D008875:Middle Aged; D011014:Pneumonia / Q000503:physiopathology*; D011650:Pulmonary Alveoli / Q000098:blood supply* / Q000503:physiopathology*; D055815:Young Adult