[Immobility and hyperthermia in tail suspension test: the association with Porsolt test and startle response in 11 inbred mouse strains, and the effect of MAO A knockout].
The tail suspension test (TST)-induced immobility and hyperthermia and acoustic startle response were studied in 11 mouse inbred strains and in MAO A knockout Tg8 mice. Significant genotypic differences in TST-induced immobility rather than hyperthermia and the lack of correlation between the expression of immobility and hyperthermia were found. Positive genotypic correlation between immobility in the TST and Porsolt test as well as TST-induced immobility and acoustic startle response was shown. Genetic knockout of the main enzyme in serotonin and catecholamines metabolism, MAO A, decreased the startle response and TST-induced hyperthermia but had no effect on TST-induced immobility in Tg8 mice indicating the differences in neurochemical regulation of these TST-induced responses. The results support the validity of the TST as dry-land version of the forced swimming test and draw attention to TST-induced hyperthermia as an animal model of response to uncontrollable, inescapable stress demonstrated in humans.
Popova
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NK
Tibeĭkina
M A
MA
D000161:Acoustic Stimulation; D000818:Animals; D005334:Fever; D019417:Hindlimb Suspension; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D008995:Monoamine Oxidase / Q000235:genetics / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D013216:Reflex, Startle / Q000502:physiology*; D013045:Species Specificity
D008995:Monoamine Oxidase