A study of the penetration of five novel synthetic steroids through hairless mouse skin in vitro.
Synopsis The change in the physiochemical properties of topical corticosteroids by addition of one or more chemical substituents is probably one of the most important factors affecting the activity and bioavailability of the steroid. During work on developing new steroids five synthetic steroids were tested for their ability to pass through freshly excised hairless mouse skin placed in diffusion cells at 33 1 degrees C. Analysis of the compounds was made using high performance liquid chromatography. The presence of flourine at carbon 9, in the chemical grouping at carbon 17, or the addition of a pentyl group was found to increase the penetration of the steroid through the skin.
Michniak-Mikolajczak
B B
BB
Postgraduate School of Studies in Pharmacy, University of Bradford, West Yorkshire, BD7 IDP, U.K., J. Hilis Miller Health Center. University of Florida, Gainesville, Florida 32610 USA.
Bodor
N
N