Spreading the silence.
RITS (RNA-induced initiation of transcriptional gene silencing complex) plays diverse roles in heterochromatin regulation: silencing transcription by recruitment of chromatin modifiers and destroying transcripts by RNAi. In a recent issue of Molecular Cell, Li et al. now show that the polymerization of Tas3, a component of RITS, contributes to the spreading of silencing mediated by RITS.
Partridge
Janet F
JF
Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. janet.partridge@stjude.org
D002503:Centromere; D020868:Gene Silencing; D006570:Heterochromatin / Q000378:metabolism; D034622:RNA Interference; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D006570:Heterochromatin