title: Blue-light phase shifts PER3 gene expression in human leukocytes.
abstract: The timing of clock gene expression in human leukocytes was investigated following a phase-advancing light stimulus to determine whether the response is wavelength- and/or age-dependent. PERIOD3 (PER3) clock gene expression in leukocytes and plasma melatonin were analyzed before and after monochromatic blue and green light exposure. Significant phase advances were observed in the peak timing of both PER3 expression and melatonin following blue but not green light. The amplitude of the PER3 rhythm at baseline was significantly reduced with age. However, age did not affect the response of the PER3 rhythm to light.
authors.affiliation: Centre for Chronobiology, University of Surrey, Guildford, UK.
authors.forename: Katrin
authors.initials: K
authors.lastname: Ackermann
authors.forename: Tracey L
authors.initials: TL
authors.lastname: Sletten
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Revell
authors.forename: Simon N
authors.initials: SN
authors.lastname: Archer
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Skene
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005786:Gene Expression Regulation; D006801:Humans; D007700:Kinetics; D007962:Leukocytes / Q000502:physiology*; D008027:Light; D008297:Male; D008550:Melatonin / Q000097:blood*; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D056950:Period Circadian Proteins; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult
chemical_list: D009687:Nuclear Proteins; C512644:PER3 protein, human; D056950:Period Circadian Proteins; D014157:Transcription Factors; D008550:Melatonin