title: Successful treatment with hydrocortisone for heat stroke with critical illness-related corticosteroid insufficiency: transitional changes in serum cytokine and cortisol concentrations.
abstract: A 37-year-old man was transferred to our emergency center because of heat stroke with circulatory shock. Despite aggressive body cooling, massive intravenous transfusion, and supply of inotropic agents, shock was persistent. To evaluate adrenal function, an adrenocorticotropic hormone stimulation test was conducted and the results indicated that he had critical illness-related corticosteroid insufficiency (CIRCI) as a result of adrenal insufficiency. Continuous hydorocortisone administration was started and he recovered from shock within a few hours. He was discharged on the thirty-seventh hospital day. Serum cortisol and cytokine concentrations were initially high and the cytokines decreased subsequent to hydrocortisone administration. It is speculated that CIRCI is an exacerbating factor in heat stroke, and hydrocortisone may be a potential therapeutic approach in such patients.
authors.affiliation: Advanced Medical Emergency And Critical Care Center, Yamaguchi University Hospital, 1-1-1 Minami-Kogushi, Ube, 755-8505, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyauchi
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tsuruta
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kutsuna
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakahara
authors.forename: Motoki
authors.initials: M
authors.lastname: Fujita
authors.forename: Shunji
authors.initials: S
authors.lastname: Kasaoka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Maekawa
mesh_terms: D000304:Adrenal Cortex Function Tests; D000305:Adrenal Cortex Hormones / Q000172:deficiency*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003422:Critical Care; D016638:Critical Illness; D016207:Cytokines / Q000097:blood*; D018883:Heat Stroke / Q000097:blood* / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006440:Hemofiltration; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000627:therapeutic use*; D008297:Male; D012769:Shock / Q000150:complications
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone