[Evolution of techniques for preparation of labile blood products (LBP): pathogen inactivation in LBP].
The techniques for inactivation of pathogens in labile blood products (LBP) would appear to be the new strategy which will permit us to increase transfusion safety in the face of the risks of transmission of pathogenic agents by LBP. Various methods are in the course of development or already validated and used in France. The latter only apply however to plasma or platelet concentrates. The mechanisms of action and the efficacy of inactivation and attenuation of pathogenic agents vary with the different techniques. Each of these constitutes a preparative procedure composed of unit steps which have to be fully mastered in order to ensure the quality and transfusion efficacy of the treated product.
Naegelen
C
C
EFS Bourgogne-Franche-Comté, 25000 Besançon, France. christian.naegelen@efs.sante.fr
Isola
H
H
Dernis
D
D
Maurel
J-P
JP
Tardivel
R
R
Bois
S
S
Vignoli
C
C
Cazenave
J-P
JP
D000094902:Blood Banking / Q000379:methods*; D001792:Blood Platelets / Q000382:microbiology; D001793:Blood Preservation / Q000379:methods*; D001803:Blood Transfusion; D017848:Blood-Borne Pathogens; D006358:Hot Temperature; D006801:Humans; D008751:Methylene Blue / Q000494:pharmacology; D055668:Photochemical Processes; D010949:Plasma; D011786:Quality Control; D012449:Safety; D014466:Ultraviolet Rays; D038301:Virus Inactivation
D008751:Methylene Blue