Chronic myelogenous leukemia showing biphenotypic blast crisis followed by lineage switch to B lymphoblastic leukemia.
Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three cases of lineage switch between lymphoid and myeloid/myelomonocytic lineages have been reported in the literature. Here, we report a novel case of imatinib-resistant CML-BC, in which the blast lineage switched from biphenotypic to B-lymphoid.
Oh
Seung Hwan
SH
Park
Tae Sung
TS
Kim
Hye Ran
HR
Lee
Ja Young
JY
Kim
Jae Hyun
JH
Shin
Jeong Hwan
JH
Lee
Jeong Nyeo
JN
D000293:Adolescent; D001752:Blast Crisis; D001853:Bone Marrow / Q000473:pathology; D019070:Cell Lineage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015448:Leukemia, B-Cell / Q000473:pathology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D008297:Male