Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform.
We report a chemically modified construct of the Sgc8 aptamer, selected against CEM cells, conjugated to an activator platform for stimulated release of molecules at the tumor surface using DNA template assisted functional group transfer reactions (DTGTR).
Mallikaratchy
Prabodhika
P
Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA.
Liu
Haipeng
H
Huang
Yu Fen
YF
Wang
Hui
H
Lopez-Colon
Dalia
D
Tan
Weihong
W
D052157:Aptamers, Nucleotide; D001483:Base Sequence; D045744:Cell Line, Tumor; D015342:DNA Probes; D006801:Humans; D008969:Molecular Sequence Data
D052157:Aptamers, Nucleotide; D015342:DNA Probes