Biochemical injury markers and mortality after coronary artery bypass grafting: a systematic review.
The strength of the association between cardiac biomarker release and prognosis is uncertain. We performed a systematic literature search to find articles regarding these markers and death after coronary surgical interventions, and evaluated the results with meta-analytic methods. We found 23 articles concerning 29,483 patients that reported the MB fraction of creatine kinase (CK-MB) and troponin T and I. Heterogeneity of existing studies prevented the pooling of the results of troponin studies. The pooled data of the CK-MB studies suggest that after coronary artery bypass grafting, CK-MB release of more than five to eight times the upper limit of the reference range is associated with an increased risk of death during the next 40 months.
Petäjä
Liisa
L
Department of Anesthesiology and Intensive Care Medicine of Helsinki University Central Hospital, Helsinki, Finland. liisa.petaja@hus.fi
Salmenperä
Markku
M
Pulkki
Kari
K
Pettilä
Ville
V
D015415:Biomarkers / Q000097:blood; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000401:mortality*; D052279:Creatine Kinase, MB Form / Q000097:blood; D006801:Humans; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis; D014336:Troponin / Q000097:blood
D015415:Biomarkers; D014336:Troponin; D052279:Creatine Kinase, MB Form