Combined phylogenetic and neighbourhood analysis of the hexose transporters and glucose sensors in yeasts.
The sugar porter family in yeasts encompasses a wide variety of transporters including the hexose transporters and glucose sensors. We analysed a total of 75 members from both groups in nine hemiascomycetous species, with complete and well-annotated genomes: Saccharomyces cerevisiae, Candida glabrata, Zygosaccharomyces rouxii, Kluyveromyces thermotolerans, Saccharomyces kluyverii, Kluyveromyces lactis, Eremothecium gossypii, Debaryomyces hansenii and Yarrowia lipolytica. We present a model for the evolution of the hexose transporters and glucose sensors, supported by two types of complementary evidences: phylogeny and neighbourhood analysis. Five lineages of evolution were identified and discussed according to different mechanisms of gene evolution: lineage A for HXT1, HXT3, HXT4, HXT5, HXT6 and HXT7; lineage B for HXT2 and HXT10; lineage C for HXT8; lineage D for HXT14; and lineage E for SNF3 and RGT2.
Palma
Margarida
M
Life Sciences Department, Centro de Recursos Microbiológicos, New University of Lisbon, Caparica, Portugal. mip@fct.unl.pt
Seret
Marie-Line
ML
Baret
Philippe V
PV
D001203:Ascomycota / Q000235:genetics*; D016000:Cluster Analysis; D019143:Evolution, Molecular; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D010802:Phylogeny; D011956:Receptors, Cell Surface / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D015003:Yeasts / Q000235:genetics*
D009004:Monosaccharide Transport Proteins; D011956:Receptors, Cell Surface; C027786:glucose receptor