Intact point-light walker processing in Williams syndrome:  a magnetoencephalography study.
Williams syndrome (WS) is a rare genetic disorder that results in profound spatial cognitive deficits. Several behavioral studies have showed that point-light walker (PLW) perception is intact in children and adults with WS; however, the neural responses underlying PLW perception in adults with WS have not been fully investigated. In this study,we studied an adult with WS by magnetoencephalography. We introduced a novel experimental technique to extract a neuromagnetic response relating to PLW perception, and then evaluated how this response differed from that in normal adults. The peak amplitude and latency of neuromagnetic responses were within 2 SD of the means among normal adults.
Hirai
Masahiro
M
Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan. hirai@nips.ac.jp
Nakamura
Miho
M
Kaneoke
Yoshiki
Y
Kakigi
Ryusuke
R
D000367:Age Factors; D000465:Algorithms; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D004185:Disability Evaluation; D007839:Functional Laterality / Q000502:physiology; D005684:Gait / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015225:Magnetoencephalography; D008297:Male; D009039:Motion Perception / Q000502:physiology*; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology; D010468:Perceptual Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013028:Space Perception / Q000502:physiology; D013997:Time Factors; D018980:Williams Syndrome / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D055815:Young Adult