CD4 expression by mast cells in mastocytosis: a case report.
A 59-year-old man presented with a five-year history of an asymptomatic widespread truncal rash. Cutaneous biopsies showed mastocytosis, which was shown to be CD4-positive immunohistochemically. This potential diagnostic pitfall in the discrimination of mastocytosis from a variety of other haematopoietic neoplasms, particularly mycosis fungoides, is discussed.
Soilleux
E J
EJ
Department of Cellular Pathology, John Radcliffe Hospital, Oxford, UK. elizabeth.soilleux@orh.nhs.uk
Bowling
J
J
Hollowood
K
K
D015415:Biomarkers / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000276:immunology* / Q000473:pathology; D008415:Mastocytosis / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D012867:Skin / Q000276:immunology* / Q000473:pathology
D015415:Biomarkers; D015704:CD4 Antigens; D019394:Ki-67 Antigen