title: [Using reverse genetics method for developing recombinant strains of influenza viruses acceptable for use as live attenuated vaccines].
abstract: Perspectives of using reverse genetics methods for constructing of recombinant influenza virus strains acceptable for use as live attenuated vaccines are discussed. Using of attenuated NS-vectors of influenza virus opens possibilities for the development of recombinant vaccines with optimal ratio of immunogenicity and safety. Reverse genetics is applicable for development of effective vaccines against new pathogens such as highly pathogenic avian influenza A/H5N1.
authors.forename: V A
authors.initials: VA
authors.lastname: Merkulov
authors.forename: V N
authors.initials: VN
authors.lastname: Lebedev
authors.forename: T M
authors.initials: TM
authors.lastname: Plekhanova
authors.forename: V A
authors.initials: VA
authors.lastname: Maksimov
authors.forename: S A
authors.initials: SA
authors.lastname: Korovkin
authors.forename: A N
authors.initials: AN
authors.lastname: Mironov
mesh_terms: D000818:Animals; D003001:Cloning, Molecular / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D009980:Influenza A virus / Q000235:genetics* / Q000276:immunology; D007252:Influenza Vaccines / Q000235:genetics* / Q000276:immunology; D007251:Influenza, Human / Q000517:prevention & control*; D014613:Vaccines, Attenuated / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology; D017361:Viral Nonstructural Proteins / Q000235:genetics* / Q000276:immunology
chemical_list: D007252:Influenza Vaccines; C108309:NS protein, influenza virus; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; D017361:Viral Nonstructural Proteins