[Mechanism of protective immunity induced by irradiation-attenuated sporozoites and its implication for pre-erythrocytic malaria vaccine research].
Irradiation-attenuated sporozoites are still the most effective pre-erythrocytic malaria vaccine However, limitation of purified sporozoites and difficulty in attenuation controlling of sporozoites hamper its use in practice. Understanding the mechanism of protective immunity induced by irradiation-attenuated sporozoites will be helpful for the design of the efficient pre-erythrocytic malaria vaccine. This is a review on research progress in the mechanism of protective immunity induced by irradiation-attenuated sporozoites and current status of pre-erythrocytic malaria vaccine development.
Xu
Wen-yue
WY
Department of Pathogenic Biology, The Third Military Medical University, Chongqing 400038, China.
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D008213:Lymphocyte Activation / Q000276:immunology; D008288:Malaria / Q000517:prevention & control; D017780:Malaria Vaccines / Q000276:immunology*; D051379:Mice; D034101:Sporozoites / Q000276:immunology* / Q000528:radiation effects; D014613:Vaccines, Attenuated / Q000276:immunology
D017780:Malaria Vaccines; D014613:Vaccines, Attenuated