title: Stress repression in restrained rats by (R)-(-)-linalool inhalation and gene expression profiling of their whole blood cells.
abstract: As an attempt to quantitatively analyze the physiopsychological effects elicited by odorants, white blood cells and gene expression were profiled in the whole blood of the rats exposed to (R)-(-)-linalool during restraint stress for 2 h. In neutrophils and lymphocytes, significant changes caused by the restraint were repressed by their exposure to the odorant. This indicates that inhalation attenuates stress-induced changes. Significant changes on the stress-induced variations were induced by inhalation in 115 gene expression levels. Of those, 109 genes were down-regulated, whereas the remaining 6 were up-regulated. These findings show that (R)-(-)-linalool inhalation represses stress-induced effects on the profiles of both blood cells and gene expression. Furthermore, these results suggest the possibility that the odorant-induced effects can be quantitatively evaluated by analyzing the profiles of blood cells and gene expression.
authors.affiliation: Technical Research Center, T Hasegawa Co, Ltd, Kawasaki-shi, Japan. akio_nakamura@t-hasegawa.co.jp
authors.forename: Akio
authors.initials: A
authors.lastname: Nakamura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Ichiro
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Abe
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D001773:Blood Cells / Q000378:metabolism*; D005503:Food Additives / Q000737:chemistry / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D019570:Inhalation Exposure; D008297:Male; D023421:Models, Animal; D039821:Monoterpenes / Q000737:chemistry / Q000378:metabolism*; D009812:Odorants; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological
chemical_list: D000080462:Acyclic Monoterpenes; D005503:Food Additives; D039821:Monoterpenes; C018584:linalool