title: Two different types of malignant fibrous histiocytomas from pet dogs.
abstract: We describe 2 cases of malignant fibrous histiocytomas (MFHs) that spontaneously developed in young pet dogs. To classify these tumors, we applied a panel of antibodies (vimentin, desmin, alpha-SMA, and ED1) and Azan staining for collagen. The MFHs were most consistent with osteoclastlike giant and inflammatory cell types. The first case had positive staining for ED1 and vimentin, and given the osteoclast-like giant cells, calcification sites accompanying peripheral giant cell infiltrates. The latter case, the inflammatory cell type, exhibited a storiform-pleomorphic variant of neoplastic cells, including an ossifying matrix. MFHs are among the most highly aggressive tumors occurring in soft tissue sarcomas in elderly dogs; however, MFHs have been poorly studied from a diagnostic point of view. Herein, we describe the histologic and immunohistologic features of MFHs in detail, thus classifying the subtypes of these tumors.
authors.affiliation: Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Do
authors.forename: Il Hwa
authors.initials: IH
authors.lastname: Hong
authors.forename: Jin Kyu
authors.initials: JK
authors.lastname: Park
authors.forename: Ae Ri
authors.initials: AR
authors.lastname: Ji
authors.forename: Tae Hwan
authors.initials: TH
authors.lastname: Kim
authors.forename: Dong Mi
authors.initials: DM
authors.lastname: Kwak
authors.forename: Kyu Shik
authors.initials: KS
authors.lastname: Jeong
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology*; D004285:Dogs; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*