title: BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery.
abstract: The analysis of known drugs (Comprehensive Medicinal Chemistry database (2008 version): http://www.mdl.com/products/knowledge/medicinal_chem/index.jsp ) and natural products (Koch et al., Proc Natl Acad Sci USA 102:17272-17277, 2008) has led to the identification of privileged saturated and aromatic heterocyclic ring pairs that we have termed as "BioCores." This article explains how the BioCores can be used for the design of novel lead-like scaffolds.
authors.affiliation: ASINEX Ltd, 20 Geroev Panfilovtzev Str. Bldg 1, Moscow, 125480, Russia. rkombarov@asinex.com
authors.forename: Roman
authors.initials: R
authors.lastname: Kombarov
authors.forename: Andrea
authors.initials: A
authors.lastname: Altieri
authors.forename: Dmitry
authors.initials: D
authors.lastname: Genis
authors.forename: Mikhail
authors.initials: M
authors.lastname: Kirpichenok
authors.forename: Valeriy
authors.initials: V
authors.lastname: Kochubey
authors.forename: Natalia
authors.initials: N
authors.lastname: Rakitina
authors.forename: Zoya
authors.initials: Z
authors.lastname: Titarenko
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry*; D016208:Databases, Factual; D055808:Drug Discovery / Q000379:methods*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D054852:Small Molecule Libraries
chemical_list: D000470:Alkaloids; D001688:Biological Products; D006571:Heterocyclic Compounds; D004364:Pharmaceutical Preparations; D054852:Small Molecule Libraries