title: Carpal tunnel syndrome.
abstract: BACKGROUND
  Carpal tunnel syndrome is a neuropathy caused by compression of the median nerve within the carpal tunnel. However, the severity of symptoms and signs does not often correlate well with the extent of nerve damage.
  
  
  METHODS
  We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of drug treatments, non-drug treatments, surgical treatments, and postoperative treatments for carpal tunnel syndrome? We searched: Medline, Embase, The Cochrane Library and other important databases up to December 2006 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
  
  
  RESULTS
  We found 54 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
  
  
  CONCLUSIONS
  In this systematic review we present information relating to the effectiveness and safety of the following interventions: acupuncture; diuretics; carpal tunnel release surgery (open, and endoscopic); internal neurolysis; local and systemic corticosteroids; massage therapy; nerve and tendon gliding exercises; non-steroidal anti-inflammatory drugs; pyridoxine; therapeutic ultrasound; and wrist splints.
authors.affiliation: University of Alberta, Edmonton, Canada.
authors.forename: Nigel L
authors.initials: NL
authors.lastname: Ashworth
mesh_terms: D002349:Carpal Tunnel Syndrome; D019635:Neurosurgical Procedures; D012449:Safety; D014481:United States