[Action of a nitric oxide donor dinitrosyl complex of iron with glutathione on hemodynamics in rats and monkeys].
We studied action of a nitric oxide donor, dinitrosyl complex of iron (DNIC) with glutathione as a ligand on the hemodynamics of normotensive Wistar rats, spontaneously hypertensive rats (SHR), and monkeys. Intravenous DNIC introduction (2-120 mg/kg) rendered fast (1-2 min) hypotensive effect combined with increased heart rate by 10-25%. Second phase of the effect in Wistar rats was characterized by slowed recovery of arterial pressure and heart rate up to initial level. A gradual DNIC breakdown in blood occurred during this period associated with increased NO accumulation in organs with intensive oxidative metabolism (liver, heart, and kidney). Duration of hypotensive effect in all animals depended on dose, this dependence was most expressed in SHR.
Lakomkin
V L
VL
Timoshin
A A
AA
Orlova
Ts R
TsR
Gubkina
S A
SA
Storozhilova
A N
AN
Gvozdik
T E
TE
Dobrovol'skiĭ
A B
AB
Ruuge
E K
EK
Vanin
A F
AF
Kapel'ko
V I
VI
Lapin
B A
BA
Chazov
E I
EI
D000818:Animals; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005978:Glutathione / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D007501:Iron / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D009589:Nitrogen Oxides / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar
D009589:Nitrogen Oxides; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D007501:Iron; D005978:Glutathione