title: HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS).
abstract: OBJECTIVE
  To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS.
  
  
  METHODS
  Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample.
  
  
  RESULTS
  In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p < 0.001). The cut-off values for IR were: HOMA1-IR > 2.7 and HOMA2-IR > 1.8; and, for MS were: HOMA1-IR > 2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR > 1.4 (sensitivity: 79.2%; specificity: 61.2%).
  
  
  CONCLUSIONS
  The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations.
authors.affiliation: Laboratório de Investigação em Metabolismo e Diabetes, Instituto Nacional de Ciência e Tecnologia, Rua Carlos Chagas 420, Campinas, SP, Brazil. bgeloneze@terra.com.br
authors.forename: Bruno
authors.initials: B
authors.lastname: Geloneze
authors.forename: Ana Carolina Junqueira
authors.initials: AC
authors.lastname: Vasques
authors.forename: Christiane França Camargo
authors.initials: CF
authors.lastname: Stabe
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Pareja
authors.forename: Lina Enriqueta Frandsen Paez de Lima
authors.initials: LE
authors.lastname: Rosado
authors.forename: Elaine Cristina de
authors.initials: EC
authors.lastname: Queiroz
authors.forename: Marcos Antonio
authors.initials: MA
authors.lastname: Tambascia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D012372:ROC Curve; D012016:Reference Values; D055815:Young Adult