Fragile histidine triad (FHIT) gene and its association with p53 protein expression in the progression of gall bladder cancer.
OBJECTIVE
Present study deals with LOH and MSI in FHIT gene and p53 expression in GBC, CC, XGC, and normal GB to elucidate the role of FHIT gene in gall bladder cancer.


METHODS
Five microsatellite markers D3S1217, D3S1300, D3S1313, D3S1600, and D3S2757, were selected.


RESULTS
Among GBC cases the frequency of MSI-H and LOH was 17.5% and 27.5%, respectively. Significant difference was found between GBC and normal GB (p = .02), and GBC and CC groups (p= .002) when LOH was compared.


CONCLUSIONS
Our results suggested CC might act as a preinvasive stage in the pathogenesis of GBC.
Priya
T Padma
TP
Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India.
Kapoor
V K
VK
Krishnani
Narendra
N
Agrawal
Vinita
V
Agarwal
Suraksha
S
D017766:Acid Anhydride Hydrolases / Q000235:genetics* / Q000502:physiology; D000328:Adult; D000368:Aged; D002764:Cholecystitis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002908:Chronic Disease; D004247:DNA / Q000097:blood / Q000235:genetics; D004273:DNA, Neoplasm / Q000097:blood / Q000235:genetics; D018450:Disease Progression; D005260:Female; D005705:Gallbladder Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D042822:Genomic Instability; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D053842:Microsatellite Instability; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D011230:Precancerous Conditions / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics*; D014973:Xanthomatosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D004247:DNA; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D016159:Tumor Suppressor Protein p53; D000099170:Bis(5'-adenosyl)triphosphatase