title: High speed, wide velocity dynamic range Doppler optical coherence tomography (Part I): System design, signal processing, and performance.
abstract: Improvements in real-time Doppler optical coherence tomography (DOCT), acquiring up to 32 frames per second at 250 x 512 pixels per image, are reported using signal processing techniques commonly employed in Doppler ultrasound imaging. The ability to measure a wide range of flow velocities, ranging from less than 20 microm/s to more than 10 cm/s, is demonstrated using an 1.3 microm DOCT system with flow phantoms in steady and pulsatile flow conditions. Based on full implementation of a coherent demodulator, four different modes of flow visualization are demonstrated: color Doppler, velocity variance, Doppler spectrum, and power Doppler. The performance of the former two, which are computationally suitable for real-time imaging, are analyzed in detail under various signal-to-noise and frame-rate conditions. The results serve as a guideline for choosing appropriate imaging parameters for detecting in vivo blood flow.
authors.forename: Victor
authors.initials: V
authors.lastname: Yang
authors.forename: Maggie
authors.initials: M
authors.lastname: Gordon
authors.forename: Bing
authors.initials: B
authors.lastname: Qi
authors.forename: Julius
authors.initials: J
authors.lastname: Pekar
authors.forename: Stuart
authors.initials: S
authors.lastname: Lo
authors.forename: Emily
authors.initials: E
authors.lastname: Seng-Yue
authors.forename: Alvin
authors.initials: A
authors.lastname: Mok
authors.forename: Brian
authors.initials: B
authors.lastname: Wilson
authors.forename: I
authors.initials: I
authors.lastname: Vitkin