title: Nurses' genetic/genomics competencies when medication therapy is guided by pharmacogenetic testing: children with mental health disorders as an exemplar.
abstract: There is considerable variability in the effectiveness and toxicity of psychotropics used to treat mental health disorders in children and adolescents. Pharmacogenetic (PG) testing is beginning to be used to decrease the time it takes to reach therapeutic response and decrease the occurrence of adverse drug reactions in children and adolescents treated with psychotropics. This article reviews the pharmacogenetics literature and uses a clinical scenario to illustrate the essential genetic/genomics competencies pediatric nurses need to meet when providing care to patients whose medication therapy is being guided by PG testing.
authors.affiliation: Division of Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. cindy.prows@cchmc.org
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Prows
authors.forename: Shannon N
authors.initials: SN
authors.lastname: Saldaña
mesh_terms: D000293:Adolescent; D002648:Child; D002983:Clinical Competence; D016903:Drug Monitoring / Q000379:methods / Q000451:nursing; D004358:Drug Therapy / Q000379:methods / Q000451:nursing; D023281:Genomics / Q000193:education / Q000379:methods; D006301:Health Services Needs and Demand; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy / Q000235:genetics / Q000451:nursing; D009722:Nurse Practitioners / Q000193:education / Q000458:organization & administration; D024802:Nurse's Role; D009730:Nursing Assessment; D010353:Patient Education as Topic; D018579:Patient Selection; D010371:Pediatric Nursing / Q000193:education / Q000379:methods*; D010597:Pharmacogenetics / Q000193:education / Q000941:ethics / Q000379:methods*; D017410:Practice Guidelines as Topic; D011568:Psychiatric Nursing / Q000193:education / Q000379:methods*; D011619:Psychotropic Drugs / Q000627:therapeutic use*
chemical_list: D011619:Psychotropic Drugs