title: Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: a dietary intervention study.
abstract: OBJECTIVE
  Some studies recently reported a favourable effect for cis-9, trans-11 conjugated linoleic acid (CLA) on plasma lipoprotein profile of healthy subjects. Aim of this crossover intervention study was to evaluate the influence of a short-term dietary intake of a cheese derived from sheep's milk naturally rich in CLA on several atherosclerotic biomarkers, in comparison with a commercially available cheese.
  
  
  RESULTS
  Ten subjects (6 F; 4 M) with a median age of 51.5 followed for 10 weeks a diet containing 200 g/week of cheese naturally rich in CLA (intervention period) and for the same period a diet containing a commercially available cheese of the same quantity (placebo period). Consumption of the dairy product naturally rich in cis-9, trans-11 CLA determined a significant (p<0.05) reduction in inflammatory parameters such as interleukin-6 (pre: 8.08+/-1.57 vs. post: 4.58+/-0.94 pg/mL), interleukin-8 (pre: 45.02+/-5.82 vs. post: 28.59+/-2.64 pg/mL), and tumour necrosis factor-alpha (pre: 53.58+/-25.67 vs. post: 32.09+/-17.42 pg/mL) whereas no significant differences in the placebo period were observed. With regard to haemorheological parameters, the test period significantly ameliorated erythrocytes' filtration rate (pre: 7.61+/-0.71% vs. post: 9.12+/-0.97%; p=0.03) with respect to the placebo period. Moreover, a reduction in the extent of platelet aggregation, induced by arachidonic acid [pre: 87.8+/-1.76% vs. post: 77.7+/-3.56%; p=0.04] was observed during the test period in comparison with the placebo period.
  
  
  CONCLUSIONS
  Dietary short-term intake of the tested dairy product naturally rich in cis-9, trans-11 CLA appeared to cause favourable biochemical changes of atherosclerotic markers.
authors.affiliation: Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy. francescosofi@gmail.com
authors.forename: F
authors.initials: F
authors.lastname: Sofi
authors.forename: A
authors.initials: A
authors.lastname: Buccioni
authors.forename: F
authors.initials: F
authors.lastname: Cesari
authors.forename: A M
authors.initials: AM
authors.lastname: Gori
authors.forename: S
authors.initials: S
authors.lastname: Minieri
authors.forename: L
authors.initials: L
authors.lastname: Mannini
authors.forename: A
authors.initials: A
authors.lastname: Casini
authors.forename: G F
authors.initials: GF
authors.lastname: Gensini
authors.forename: R
authors.initials: R
authors.lastname: Abbate
authors.forename: M
authors.initials: M
authors.lastname: Antongiovanni
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D002611:Cheese; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D018592:Cross-Over Studies; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D018056:Hemorheology / Q000187:drug effects*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007378:Interleukins / Q000097:blood; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008892:Milk; D010974:Platelet Aggregation / Q000187:drug effects; D012756:Sheep; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D018836:Inflammation Mediators; D007378:Interleukins; D044243:Linoleic Acids, Conjugated; D008055:Lipids; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C503589:cis-9, trans-11-conjugated linoleic acid; D002784:Cholesterol