title: Histone acetyltransferase inhibitors and preclinical studies.
abstract: BACKGROUND
  Drugs able to regulate the histone modifier enzymes are very promising tools for the treatment of several diseases, such as cancer. Histone acetyltransferase (HAT) inhibitors are compounds able to inhibit the catalytic activity of HATs reported to be active in cancer, or in several other diseases, such as Alzheimer (AD), diabetes and hyperlipidaemia.
  
  
  OBJECTIVE
  Here we review the status and the rationale for the use of HAT inhibitors in the treatment of various diseases.
  
  
  METHODS
  Patents have been found on the espacenet database; the clinical trials have been reported as in the clinicaltrial.gov website.
  
  
  CONCLUSIONS
  Despite the fact that other drugs able to regulate the histone modifier enzymes (such as histone deacetylase inhibitors) have been already approved for the treatment of cancer, HAT inhibitors seem promising for the treatment of human diseases such as AD and diabetes, although side effects and toxicity need to be investigated.
authors.affiliation: Dipartimento di Patologia generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, 80138, Napoli, IT. lucia.altucci@unina2.it
authors.forename: Fabio
authors.initials: F
authors.lastname: Manzo
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: Tambaro
authors.forename: Antonello
authors.initials: A
authors.lastname: Mai
authors.forename: Lucia
authors.initials: L
authors.lastname: Altucci
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002986:Clinical Trials as Topic; D003474:Curcumin / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D051548:Histone Acetyltransferases / Q000037:antagonists & inhibitors*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D010330:Patents as Topic
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D051548:Histone Acetyltransferases; D003474:Curcumin