title: Bis-neonicotinoid insecticides: Observed and predicted binding interactions with the nicotinic receptor.
abstract: The bis-pharmacophore approach applied to neonicotinoid insecticides reveals high binding affinity for heptamethylene bis-N(3),N(3')-imidacloprid fitting a nicotinic acetylcholine receptor model wherein the chloropyridine moieties contact loops E and F and the alkylene linker bridges these two distant domains.
authors.affiliation: Department of Chemistry, Faculty of Education, Gifu University, Gifu 501-1193, Japan.
authors.forename: Ikuya
authors.initials: I
authors.lastname: Ohno
authors.forename: Motohiro
authors.initials: M
authors.lastname: Tomizawa
authors.forename: Motohiro
authors.initials: M
authors.lastname: Tomizawaa
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Durkin
authors.forename: John E
authors.initials: JE
authors.lastname: Casida
authors.forename: Shinzo
authors.initials: S
authors.lastname: Kagabu
mesh_terms: D000818:Animals; D001665:Binding Sites; D003198:Computer Simulation; D004330:Drosophila; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry*; D000073943:Neonicotinoids; D018733:Nicotinic Antagonists / Q000138:chemical synthesis / Q000737:chemistry*; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011485:Protein Binding; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D018733:Nicotinic Antagonists; D009574:Nitro Compounds; D011978:Receptors, Nicotinic; C082359:imidacloprid