title: PET imaging of redox and energy states in stroke-like episodes of MELAS.
abstract: In stroke-like episodes of patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), changes in oxidative stress and glucose metabolism and their sequence remain obscure. We developed a novel double imaging method using positron emission tomography (PET) with [(62)Cu]-diacetyl-bis(N4-methylthiosemicarbazone) ((62)Cu-ATSM) and [(18)F]-fluorodeoxyglucose ((18)FDG) to visualize the regional oxidative stress, glucose metabolism and blood flow in brain lesions of stroke-like episodes non-invasively and rapidly. These PET imagings were performed on a MELAS patient with stroke-like lesions, and clearly demonstrated that oxidative stress following hyperemia along with increased glucose metabolism plays crucial roles in the pathogenesis of MELAS stroke-like episodes.
authors.affiliation: Second Department of Internal Medicine (Neurology), Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaiduki, Matsuoka, Eiheiji-cho, Fukui 910-1193, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Ikawa
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Okazawa
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Arakawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kudo
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kimura
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Fujibayashi
authors.forename: Masaru
authors.initials: M
authors.lastname: Kuriyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoneda
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017241:MELAS Syndrome / Q000473:pathology*; D018384:Oxidative Stress; D049268:Positron-Emission Tomography; D011859:Radiography; D012039:Regional Blood Flow
chemical_list: D005947:Glucose