title: Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
abstract: We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
authors.affiliation: Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK.
authors.forename: John R B
authors.initials: JR
authors.lastname: Perry
authors.forename: Lisette
authors.initials: L
authors.lastname: Stolk
authors.forename: Nora
authors.initials: N
authors.lastname: Franceschini
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Lunetta
authors.forename: Guangju
authors.initials: G
authors.lastname: Zhai
authors.forename: Patrick F
authors.initials: PF
authors.lastname: McArdle
authors.forename: Albert V
authors.initials: AV
authors.lastname: Smith
authors.forename: Thor
authors.initials: T
authors.lastname: Aspelund
authors.forename: Stefania
authors.initials: S
authors.lastname: Bandinelli
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
authors.forename: Lynn
authors.initials: L
authors.lastname: Cherkas
authors.forename: Gudny
authors.initials: G
authors.lastname: Eiriksdottir
authors.forename: Karol
authors.initials: K
authors.lastname: Estrada
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Folsom
authors.forename: Melissa
authors.initials: M
authors.lastname: Garcia
authors.forename: Vilmundur
authors.initials: V
authors.lastname: Gudnason
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: David
authors.initials: D
authors.lastname: Karasik
authors.forename: Douglas P
authors.initials: DP
authors.lastname: Kiel
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
authors.forename: Joyce
authors.initials: J
authors.lastname: van Meurs
authors.forename: Michael A
authors.initials: MA
authors.lastname: Nalls
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivadeneira
authors.forename: Alan R
authors.initials: AR
authors.lastname: Shuldiner
authors.forename: Andrew
authors.initials: A
authors.lastname: Singleton
authors.forename: Nicole
authors.initials: N
authors.lastname: Soranzo
authors.forename: Toshiko
authors.initials: T
authors.lastname: Tanaka
authors.forename: Jenny A
authors.initials: JA
authors.lastname: Visser
authors.forename: Michael N
authors.initials: MN
authors.lastname: Weedon
authors.forename: Scott G
authors.initials: SG
authors.lastname: Wilson
authors.forename: Vivian
authors.initials: V
authors.lastname: Zhuang
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Streeten
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.forename: Anna
authors.initials: A
authors.lastname: Murray
authors.forename: Tim D
authors.initials: TD
authors.lastname: Spector
authors.forename: Ellen W
authors.initials: EW
authors.lastname: Demerath
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Murabito
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015992:Body Mass Index; D002648:Child; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D008572:Menarche / Q000235:genetics*; D015201:Meta-Analysis as Topic; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins; D012741:Sexual Maturation / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; C516326:LIN28B protein, human; D016601:RNA-Binding Proteins