Influence of antigen exposure on the loss of long-term memory to childhood vaccines in HIV-infected patients.
The role of antigen exposure and of CD4 cell deficiency in the long-term persistence of immune memory to childhood vaccines remains uncertain, particularly during HIV infection. We analyzed in vaccinated ART-treated HIV+ patients with undetectable plasma HIV and CD4 cells >250/mm(3) the persistence of two memory cell pools: effector IFNgamma-producing and proliferative central memory T cells against two vaccines: (i) vaccinia against the eradicated smallpox virus, and (ii) BCG against Mtb, a persistent pathogen. None of the HIV+ patients had IFNgamma-effector cells against VV while the one patient with BCG-specific effector T cells had a recent history of tuberculosis. Proliferative responses were detectable but showed significantly lower frequency and intensity of VV-specific than tuberculin-specific responses, independently of the CD4 nadir. Thus, differential patterns of persistence or recovery of T cell memory pools against childhood vaccines are observed in treated HIV infection that are governed by antigen exposure.
Puissant-Lubrano
Bénédicte
B
Inserm, UMRS-945 Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris F-75013, France.
Combadière
Béhazine
B
Duffy
Darragh
D
Wincker
Norma
N
Frachette
Marie-Joelle
MJ
Ait-Mohand
Hocine
H
Verrier
Bernard
B
Katlama
Christine
C
Autran
Brigitte
B
D000328:Adult; D001500:BCG Vaccine / Q000276:immunology*; D005260:Female; D015488:HIV Antigens / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination; D014615:Vaccinia / Q000276:immunology*
D001500:BCG Vaccine; D015488:HIV Antigens; D007371:Interferon-gamma