Feasibility of xanthan gum-sodium alginate as a transdermal drug delivery system for domperidone.
The present investigation comprises the formulation and in vitro evaluation of domperidone loaded transdermal drug delivery system (TDDS) for controlled release. The polymer membranes were prepared using xanthan gum (XG) and sodium alginate (SA) by varying the blends compositions viz., 10:0, 8:2, 6:4, 5:5, 4:6, 2:8, and 0:10 (XG/SA, wt/wt, %). The drug loaded membranes were evaluated for thickness, content uniformity, tensile behaviours, and in vitro drug release studies. Domperidone was found to be compatible with the prepared formulation as revealed by Fourier transform infrared (FTIR) spectroscopy studies. In vitro release studies were carried out in open glass diffusion cell for a period of 8 h and it showed controlled release of drug from the XG/SA matrix. The present study concludes that, the prepared transdermal films can be used to achieve controlled release of drug and improved bioavailability.
Rajesh
N
N
Department of Polymer Science and Technology, Sri Jayachamarajendra College of Engineering, Mysore 570 006, India. rajeshnayakmysore@rediffmail.com
Siddaramaiah
D000279:Administration, Cutaneous; D000464:Alginates / Q000737:chemistry*; D000932:Antiemetics / Q000008:administration & dosage; D001696:Biomechanical Phenomena; D004058:Diffusion; D004294:Domperidone / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D004355:Drug Stability; D005240:Feasibility Studies; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008567:Membranes, Artificial; D008962:Models, Theoretical; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D000464:Alginates; D000932:Antiemetics; D006603:Hexuronic Acids; D008567:Membranes, Artificial; D011108:Polymers; D011135:Polysaccharides, Bacterial; D004294:Domperidone; D020723:Glucuronic Acid; C002563:xanthan gum