title: Neuromelanins in various regions of human brain are associated with native and oxidized isoprenoid lipids.
abstract: Neuromelanin (NM) isolated from seven regions of the human brain is found to contain series of natural and oxidized isoprenoid lipids. Specifically, dolichols (dol) and dolichoic acids (dol-CA) with 14-22 and 14-21 isoprene units are identified. Standards of nor-dolichol and nor-dolichoic acid were used to determine the relative amounts of dol and dol-CA compared to the total lipids present in NM for each region. The cerebellum, putamen, globus pallidus, and premotor cortex contained similar amounts of dol, comprising approximately 8-9.5% of the total lipid weight. Interestingly, the corpus callosum contains substantially lower quantities of both dol and dol-CA compared to the other regions-less than 4% dol relative to the total lipid weight. Oxidized and reduced dolichol-related species were identified and determined to be region-dependent.
authors.affiliation: Department of Chemistry, Duke University, Durham, NC 27708, USA.
authors.forename: Weslyn C
authors.initials: WC
authors.lastname: Ward
authors.forename: Fabio A
authors.initials: FA
authors.lastname: Zucca
authors.forename: Chiara
authors.initials: C
authors.lastname: Bellei
authors.forename: Luigi
authors.initials: L
authors.lastname: Zecca
authors.forename: John D
authors.initials: JD
authors.lastname: Simon
mesh_terms: D001921:Brain / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D050356:Lipid Metabolism; D013058:Mass Spectrometry; D008543:Melanins / Q000378:metabolism*; D010084:Oxidation-Reduction; D013729:Terpenes / Q000378:metabolism*
chemical_list: D008543:Melanins; D013729:Terpenes; C014121:neuromelanin