title: Cumulative results including obstetrical and neonatal outcome of fresh and frozen-thawed cycles in elective single versus double fresh embryo transfers.
abstract: OBJECTIVE
  To assess the efficacy of elective single embryo transfer (e-SET) compared to a double embryo transfer (DET) in a selected population including obstetrical and neonatal outcome of fresh and frozen-thawed cycles.
  
  
  METHODS
  Prospective nonrandomized study.
  
  
  METHODS
  Department of reproductive medicine.
  
  
  METHODS
  Elective single embryo transfer was proposed to women < 36 years with adequate ovarian function, in their first or second IVF or intracytoplasmic sperm injection (ICSI) attempt with ejaculated sperm, with at least 4 mature oocytes and 2 fertilized top quality embryos. Patients who refused e-SET had two top embryos transferred (DET group).
  
  
  METHODS
  Medical management and IVF-ICSI.
  
  
  METHODS
  Cumulative delivery rate, twin delivery rate, obstetrical and neonatal outcome.
  
  
  RESULTS
  According to patients' decision, 53 women had an e-SET and 98 a DET. The cumulative delivery rate per patient was 54.7% in the e-SET group and 49.0% in the DET group (P>0.05). Twin delivery rate was significantly different between the two groups (3.5% versus 37.5% respectively, P<0.05). Neonatal outcome in twins resulting from IVF-ICSI was found to be poorer than in singletons, considering the mean gestational age, mode of delivery, birthweight, and risk of neonatal intensive care unit admission for the infants.
  
  
  CONCLUSIONS
  In a selected population, the elective transfer of one embryo with high implantation potential helped to avoid twin pregnancies without decreasing delivery rate.
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Laboratoire de Biologie de la Reproduction, Hôpital Cochin, Paris, France. patricia.fauque@cch.aphp.fr
authors.forename: Patricia
authors.initials: P
authors.lastname: Fauque
authors.forename: Pierre
authors.initials: P
authors.lastname: Jouannet
authors.forename: Céline
authors.initials: C
authors.lastname: Davy
authors.forename: Juliette
authors.initials: J
authors.lastname: Guibert
authors.forename: Vivian
authors.initials: V
authors.lastname: Viallon
authors.forename: Sylvie
authors.initials: S
authors.lastname: Epelboin
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Kunstmann
authors.forename: Catherine
authors.initials: C
authors.lastname: Patrat
mesh_terms: D000328:Adult; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D017558:Elective Surgical Procedures; D004624:Embryo Transfer / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D005615:Freezing; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009865:Oocytes; D011247:Pregnancy; D011272:Pregnancy, Multiple / Q000706:statistics & numerical data; D056826:Single Embryo Transfer / Q000706:statistics & numerical data; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D014021:Tissue Preservation / Q000379:methods*; D016896:Treatment Outcome; D014427:Twins; D055815:Young Adult