p-Terphenyls from the fruiting bodies of Paxillus curtisii and their antioxidant properties.
New p-terphenyls, curtisians R (1)-V (5), have been isolated together with known compounds, curtisians E, I-P, and kynapcin-12, from the methanolic extract of the fruiting bodies of Paxillus curtisii (Paxillaceace). Their structures were established by various spectroscopic analyses including 1D- and 2D-NMR experiments, as well as high-resolution FAB-mass analysis. They exhibited significant protective effects against oxidative damage of supercoiled DNA and 2-deoxyribose by hydroxyl radicals generated from the Fenton reaction.
Lee
In-Kyoung
IK
Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan, Jeonbuk, Republic of Korea.
Jung
Jin-Young
JY
Kim
Young-Sook
YS
Rhee
Man Hee
MH
Yun
Bong-Sik
BS
D000363:Agaricales / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects; D004278:DNA, Superhelical / Q000378:metabolism; D003855:Deoxyribose / Q000378:metabolism; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013730:Terphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000975:Antioxidants; D004278:DNA, Superhelical; D016166:Free Radical Scavengers; D013730:Terphenyl Compounds; D003855:Deoxyribose