title: Nitrogen plasma skin regeneration and aesthetic facial surgery: multicenter evaluation of concurrent treatment.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of aesthetic facial surgery with concurrent nitrogen plasma skin regeneration.
  
  
  METHODS
  During a 28-month period, we independently completed 272 concurrent procedures in 95 patients aged 42 to 80 years in whom nitrogen plasma skin regeneration was performed immediately on completion of various aesthetic procedures, including brow-lift, blepharoplasty, lateral canthoplasty, midface-lift, rhytidectomy, cheek augmentation, lip vermillion advancement, filler injections, and augmentation mentoplasty. The treatment variables evaluated included nitrogen plasma pulse energy, pass number, and pulse count, and outcomes monitored included complications and subjective aesthetic improvement.
  
  
  RESULTS
  The various treatment combinations were well tolerated at all anatomical sites. Rhytidectomy flap treatment included escalation of single-pass low-energy to high-energy nitrogen plasma treatment. Although perioperative complications did not otherwise negatively affect results, they included erythema with acneiform eruption (in 2 patients) and presumed herpes simplex virus infection, brief healing delay, and postinflammatory hyperpigmentation (in 1 patient each). In general, the treatment combinations were synergistic.
  
  
  CONCLUSIONS
  Combining nitrogen plasma skin regeneration with aesthetic facial surgery enhances outcomes for procedures in the forehead and in the periorbital, midface, and perioral regions. It does not seem to increase the risk of dermatologic or surgical complications for the procedures described herein.
authors.affiliation: Holcomb Facial Plastic Surgery, 1 S School Ave, Sarasota, FL 34237, USA. drholcomb@srqfps.com
authors.forename: J David
authors.initials: JD
authors.lastname: Holcomb
authors.forename: Kriston J
authors.initials: KJ
authors.lastname: Kent
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Rousso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003357:Cosmetic Techniques; D005145:Face; D005260:Female; D005740:Gases / Q000627:therapeutic use; D006801:Humans; D006979:Hyperthermia, Induced; D007477:Ions; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000627:therapeutic use*; D012038:Regeneration; D012060:Rejuvenation; D015595:Skin Aging; D012879:Skin Physiological Phenomena; D016896:Treatment Outcome
chemical_list: D005740:Gases; D007477:Ions; D009584:Nitrogen