PGP 9.5 and cyclin D1 coexpression in cutaneous squamous cell carcinomas.
BACKGROUND
squamous cell carcinoma (SCC) consists of altered keratinocytes, presents variable differentiation, inexorably progresses, and on occasion metastasizes.


OBJECTIVE
to investigate the biological activity of epidermal cells in SCCs by estimating the expression of PGP 9.5 and cyclin D1 using immunohistochemistry.


METHODS
the sample included 13 well-differentiated cases of cutaneous SCC (grade I), 12 moderately differentiated tumors (grade II), and 7 poorly differentiated lesions (grade III). Four cases belonged to the distinct entity of pseudoadenoid SCC.


RESULTS
PGP 9.5 expression was positively correlated with tumor stage (P < .001) and potential perineural invasion ( P < .001), whereas cyclin D1 expression correlated inversely with the degree of cellular differentiation (P < .001) and PGP 9.5 immunostaining (P < .001).


CONCLUSIONS
PGP 9.5 and cyclin D1 coexpression was closely associated with tumor aggressiveness and can be classified as a marker for predicting the outcome of resection-treated skin cancer patients.
Mastoraki
Aikaterini
A
4th Department of Surgery, Athens University Medical School, Attikon University Hospital, Athens, Greece. dr_kamast@yahoo.gt
Ioannidis
Eleftherios
E
Apostolaki
Aikaterini
A
Patsouris
Efstratios
E
Aroni
Kiriaki
K
D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D019938:Cyclin D1 / Q000378:metabolism*; D004817:Epidermis / Q000378:metabolism* / Q000473:pathology; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007124:Immunoenzyme Techniques; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D010525:Peripheral Nerves / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D043222:Ubiquitin Thiolesterase / Q000378:metabolism*
D014408:Biomarkers, Tumor; C530104:CCND1 protein, human; C482860:UCHL1 protein, human; D019938:Cyclin D1; D043222:Ubiquitin Thiolesterase