Sesquiterpene lactone 12,8-eudesmanolides from the fungus Xylaria ianthinovelutina.
The investigation of Xylaria ianthinovelutina (Mont.) led to the isolation of four new 12,8-eudesmanolides (1-4). Their structures were determined by spectroscopy and the relative stereochemistry was assigned based on NOESY and CD spectral data. Compounds 1-4 exhibited biological activity against Plasmodium falciparum K-1 strain, NCI-H187, KB, MCF-7 with IC(50) values varying in the range 0.78-19.15 microg/mL.
Pittayakhajonwut
Pattama
P
National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani, Thailand. pattamap@biotec.or.th
Usuwan
Atit
A
Intaraudom
Chakapong
C
Veeranondha
Sukitaya
S
Srikitikulchai
Prasert
P
D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D013098:Xylariales / Q000737:chemistry*
D000962:Antimalarials; D000970:Antineoplastic Agents; D007783:Lactones; D012717:Sesquiterpenes