title: Primary prevention of CVD: physical activity.
abstract: BACKGROUND
  Increasing physical activity has been associated with reduced risk of mortality and of cardiovascular disease. The proportion of people doing no physical activity in a week varies between countries, but can reach nearly 25% in Europe and the Americas.
  
  
  METHODS
  We conducted a systematic review and aimed to answer the following clinical questions: Does counselling people in the general population to increase physical activity lead to increased physical activity? What are the health benefits of increasing physical activity in relation to cardiovascular outcomes in the general population? We searched: Medline, Embase, The Cochrane Library and other important databases up to June 2006 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
  
  
  RESULTS
  We found 17 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
  
  
  CONCLUSIONS
  In this systematic review we present information relating to the effectiveness and safety of the following interventions: counselling people to increase physical activity, and to perform higher-intensity exercise programmes.
authors.affiliation: School of Sport and Exercise Sciences, Loughborough University, Loughborough, UK.
authors.forename: David
authors.initials: D
authors.lastname: Stensel
mesh_terms: D000367:Age Factors; D002110:Caffeine; D002318:Cardiovascular Diseases; D005767:Gastrointestinal Diseases; D006801:Humans; D008137:Longitudinal Studies; D009043:Motor Activity; D011322:Primary Prevention; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D014486:United States Food and Drug Administration
chemical_list: D002110:Caffeine