Myxobacteria--'microbial factories' for the production of bioactive secondary metabolites.
In this article, we briefly review the potential of myxobacteria as 'natural product factories' by highlighting results from the recently sequenced myxobacterial model strain Myxococcus xanthus. We will focus on the production of polyketides, non-ribosomally-made peptides, and their hybrids, and discuss the evaluation of biosynthetic potential using genome-based methods, as well as biosynthetic process engineering.
Wenzel
Silke C
SC
Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.
Müller
Rolf
R
D053898:Biosynthetic Pathways; D034261:Epothilones / Q000096:biosynthesis / Q000737:chemistry; D015964:Gene Expression Regulation, Bacterial; D005818:Genetic Engineering; D007218:Industrial Microbiology / Q000379:methods*; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism; D009231:Myxococcales / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D016941:Myxococcus xanthus / Q000235:genetics / Q000378:metabolism
D034261:Epothilones; D018942:Macrolides