title: [Effects of novel antiviral agents on HIV-1 replication].
abstract: Two groups of the antiviral agents: 1) adamantane- and norbornen-containing compounds with in-built cholesterol to potentiate the membranotropic properties and 2) synthetic matrix protein peptides (peptides A and B) were found to have effects on HIV replication. The agents of the former group produced antiviral activity only when added in combination with the virus. Peptide A (matrix protein 43-60 amino acids) inhibited viral replication when added in both the early and late periods. Fluorescein-labeled peptide A was detectable in the cytoplasm and nucleus (although adsorption of a portion of the peptides cannot be excluded onto the cell surface). Peptide A was shown to inhibit Gag precursor p55 transport from the nuclei to the plasma membrane, the site of virus assembly. Peptide B had no antiviral activity.
authors.forename: G K
authors.initials: GK
authors.lastname: Vorkunova
authors.forename: L B
authors.initials: LB
authors.lastname: Kalnina
authors.forename: M E
authors.initials: ME
authors.lastname: Burshteĭn
authors.forename: A V
authors.initials: AV
authors.lastname: Serbin
authors.forename: I L
authors.initials: IL
authors.lastname: Rodionov
authors.forename: M V
authors.initials: MV
authors.lastname: Pavlova
authors.forename: A G
authors.initials: AG
authors.lastname: Bukrinskaia
mesh_terms: D000218:Adamantane / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009636:Norbornanes / Q000494:pharmacology*; D015688:Oncogene Protein pp60(v-src) / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011498:Protein Precursors / Q000037:antagonists & inhibitors / Q000378:metabolism; D021381:Protein Transport / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents; D009636:Norbornanes; D010446:Peptide Fragments; D011498:Protein Precursors; C059767:p55 gag precursor protein, Human immunodeficiency virus 1; C098708:peptide A; D015688:Oncogene Protein pp60(v-src); D000218:Adamantane