[Detection of visfatin level of plasma in patients with coronary artery diseases].
OBJECTIVE
To study the plasma visfatin level in patients with coronary artery disease (CAD) and evaluate the correlation between plasma visfatin level and coronary lesion severity.


METHODS
The level of plasma visfatin of 48 patients with CAD (proved by angiography) and 41 normal controls were detected and compared. Plasma visfatin was determined by an enzyme immunoassay. The lesion severity of coronary arteries was assessed by Gensini coronary scoring system, and the correlation between plasma visfatin level and coronary lesion severity was evaluated.


RESULTS
Plasma visfatin level in the CAD group was significantly higher than that in the control group [(28.58 +/- 14.53) ng/mL vs. [16.01 +/- 6.09) ng/mL, P < 0.01]. A significant positive correlation was found between coronary lesion severity score and Plasma visfatin level (r = 0.906, P < 0.01).


CONCLUSIONS
Plasma visfatin level may be related to the pathogenesis of CAD. Detection of plasma visfatin might be helpful for early diagnosis of CAD, and patients with higher Plasma visfatin level may have more severe coronary lesion.
Fu
Hua
H
Laboratory of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhu
Ye
Y
You
Gui-ying
GY
Liu
Xiao-jing
XJ
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D012720:Severity of Illness Index
D054409:Nicotinamide Phosphoribosyltransferase