title: Immunogenetics of drug-induced skin blistering disorders. Part II: synthesis.
abstract: The overall immunopathogenesis relevant to a large series of disorders caused by a drug or its associated hyperimmune condition is discussed based upon examining the genetics of severe drug-induced bullous skin problems (sporadic idiosyncratic adverse events including Stevens-Johnson syndrome and Toxic epidermal necrolysis). New results from an exemplar study on shared precipitating and perpetuating inner causes with other related disease phenotypes including aphtous stomatitis, Behçets, erythema multiforme, Hashimoto's thyroiditis, pemphigus, periodic fevers, Sweet's syndrome and drug-induced multisystem hypersensitivity are presented. A call for a collaborative, wider demographic profiling and deeper immunotyping in suggested future work is made.
authors.affiliation: School of Biological Sciences, University of Reading, Whiteknights, Reading, UK. c.e.bowman@reading.ac.uk
authors.forename: Clive
authors.initials: C
authors.lastname: Bowman
authors.forename: Olivier
authors.initials: O
authors.lastname: Delrieu
mesh_terms: D001768:Blister / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D003580:Cytochromes / Q000235:genetics; D003710:Demography; D014644:Genetic Variation; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology; D055261:Immunogenetic Phenomena
chemical_list: D003580:Cytochromes; D006680:HLA Antigens; D015235:HLA-B Antigens; D015395:Histocompatibility Antigens Class I