Colonic carcinoma metastatic to the endometrium: the importance of clinical history in averting misdiagnosis as a primary endometrial carcinoma.
Metastases to endometrium are a rare event. A case of a 53-year-old woman with a previous colon cancer presenting with a dysfunctional uterine bleeding is reported. The curettage specimens consisted of multiple fragments of proliferative endometrial tissue mixed with irregular glands, focally amputated, lined by very cells with elongated, hyperchromatic nuclei and solid sheets of neoplastic cells often filled with necrotic debris and inflammatory cells, resembling endometrioid adenocarcinoma. Neoplastic cells resulted positive at immunohistochemical reaction for CK20, CDX2, p53 and negative for CK7, vimentin, ER, and PR suggesting a metastatic colon adenocarcinoma. Absence of premalignant changes, such as hyperplasia, besides frankly malignant glands in an endometrial curette should be regarded as an alarming feature for a secondary nature mostly from large bowel. In these cases clinical history is crucial and an immunohistochemical panel made up of CK7, CK20, CDX2, p53, vimentin, ER, and PR is useful for the correct diagnosis.
Zannoni
Gian Franco
GF
Department of Pathology, Policlinico A. Gemelli, Catholic University, Largo A. Gemelli 8, 00168 Rome, Italy. gfzannoni@rm.unicatt.it
Vellone
Valerio Gaetano
VG
Fadda
Guido
G
Petrillo
Marco
M
Scambia
Giovanni
G
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary; D014408:Biomarkers, Tumor / Q000378:metabolism; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary; D003475:Curettage; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control*; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry / Q000379:methods; D008875:Middle Aged
D014408:Biomarkers, Tumor