title: Effect of baseline plasma fatty acids on eicosapentaenoic acid levels in individuals supplemented with alpha-linolenic acid.
abstract: We previously reported a >50% increase in mean plasma eicosapentaenoic acid levels in a general medicine clinic population after supplementation with alpha-linolenic acid. In the current analysis, we evaluate the variability of changes in eicosapentaenoic acid levels among individuals supplemented with alpha-linolenic acid and evaluated the impact of baseline plasma fatty acids levels on changes in eicosapentaenoic acid levels in these individuals. Changes in eicosapentaenoic acid levels among individuals supplemented with alpha-linolenic acid ranged from a 55% decrease to a 967% increase. Baseline plasma fatty acids had no statistically significant effect on changes in eicosapentaenoic levels acid after alpha-linolenic acid supplementation. Changes in eicosapentaenoic acid levels varied considerably in a general internal medicine clinic population supplemented with alpha-linolenic acid. Factors that may impact changes in plasma eicosapentaenoic acid levels after alpha-linolenic acid supplementation warrant further study.
authors.affiliation: The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, 600 North Wolf Street, Baltimore, MD 21287, USA. APDeF@yahoo.com
authors.forename: Andrew P
authors.initials: AP
authors.lastname: DeFilippis
authors.forename: Charles R
authors.initials: CR
authors.lastname: Harper
authors.forename: George A
authors.initials: GA
authors.lastname: Cotsonis
authors.forename: Terry A
authors.initials: TA
authors.lastname: Jacobson
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000517:prevention & control; D015930:Diet Records; D018752:Diet, Fat-Restricted; D019587:Dietary Supplements / Q000009:adverse effects; D015118:Eicosapentaenoic Acid / Q000097:blood*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D008043:Linseed Oil / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011795:Surveys and Questionnaires; D013997:Time Factors; D017962:alpha-Linolenic Acid / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D005227:Fatty Acids; D017962:alpha-Linolenic Acid; D008043:Linseed Oil; D015118:Eicosapentaenoic Acid