title: Past and current weight change and forearm bone loss in middle-aged women: the Nord-Trøndelag Health Study, Norway.
abstract: OBJECTIVE
  The aim of this study was to investigate the association between bone loss and weight change before and concurrently to the assessment of forearm bone loss over 4.6 years in a population-based cohort of middle-aged women followed for more than 15 years.
  
  
  METHODS
  Among 8,856 women aged 45 to 60 years attending the first Nord-Trøndelag Health Study study, Norway (1984-1986), a 35% random sample was invited for forearm densitometry at Nord-Trøndelag Health Study 2 (1995-1997), and 2,188 women (78%) attended. After an average period of 4.6 years, they were subsequently invited for follow-up densitometry in 2001, and 1,421 women (67.8%) met. Weight and height were measured on all three occasions.
  
  
  RESULTS
  During the total period of observation since baseline (15.5 y), the mean weight had increased by 3.4 kg, mostly in the youngest women. Weight loss had an accelerating and weight gain a decelerating effect on bone loss, and this was observed both for weight change occurring before the bone mineral density follow-up and for concurrent weight change. The relationship between prior weight gain or loss and bone loss seemed to persist, independent of the weight change observed during the period of bone loss assessment.
  
  
  CONCLUSIONS
  Despite no mechanical impact of body weight on the forearm, weight loss in midlife women seems to be associated with a long-lasting negative effect on bone and vice versa for weight gain. This is presumably explained by humoral factors.
authors.affiliation: Department of Public Health and General Practice, Norwegian Univeristy of Science and Technology, Trondheim, Norway. siri.forsmo@ntnu.no
authors.forename: Siri
authors.initials: S
authors.lastname: Forsmo
authors.forename: Arnulf
authors.initials: A
authors.lastname: Langhammer
authors.forename: Berit
authors.initials: B
authors.lastname: Schei
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D001835:Body Weight; D015519:Bone Density; D005260:Female; D005542:Forearm; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D010024:Osteoporosis / Q000503:physiopathology*; D015430:Weight Gain / Q000502:physiology; D015431:Weight Loss / Q000502:physiology