title: Human papillomavirus-58 and -73-associated digital squamous cell carcinoma in a patient with aggressive digital papillary adenocarcinoma.
abstract: Aggressive digital papillary adenocarcinoma (ADPA) is a rare tumor that is considered to arise from eccrine sweat glands of the skin. It occurs predominantly in men with a mean age in the sixth decade. It shows a strong tendency for local recurrence and has the potential to metastasize to distant sites. Prompt diagnosis and regular follow-up are important to ensure the best possible outcome. We discuss a case of recurrent ADPA associated with subsequent squamous cell carcinoma (SCC) in different contralateral digits in a 55-year-old man. One SCC lesion tested positive for human papillomavirus (HPV)-58. HPV-associated digital SCCs have been reported; most cases are HPV-16 positive. This report describes a rare case of an HPV-58-positive invasive digital SCC and an HPV-73-positive SCC in situ associated with ADPA.
authors.affiliation: Department of Pathology, University of Missouri-Kansas City, School of Medicine, Truman Medical Center, Kansas City, MO, USA.
authors.forename: William
authors.initials: W
authors.lastname: DePond
authors.forename: Kiyoe
authors.initials: K
authors.lastname: Kure
authors.forename: Kamani
authors.initials: K
authors.lastname: Lankachandra
authors.forename: Raja
authors.initials: R
authors.lastname: Gidwani
authors.forename: Brook V
authors.initials: BV
authors.lastname: Nelson
authors.forename: Hannah
authors.initials: H
authors.lastname: Zimmerman
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Talboy
authors.forename: Roberto N
authors.initials: RN
authors.lastname: Miranda
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000473:pathology / Q000821:virology*; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D005385:Fingers / Q000473:pathology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology / Q000821:virology*