title: No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population.
abstract: Panic disorder (PD) is a severe and chronic psychiatric disorder, with significant genetic components in the etiology. Brain-derived neurotrophic factor (BDNF) gene, which has regulatory effects on neurotransmitter systems such as serotonin and dopamine, is a candidate for susceptibility locus of PD. This study investigated three single-nucleotide polymorphisms (SNPs) of BDNF (rs6265 (Val66Met), rs11030104 and rs7103411) in Japanese patients with PD and controls. No significant association was observed between the three SNPs and PD. No association of the Val66Met was consistent with two small studies in Japanese and Chinese populations. We therefore conclude that the BDNF polymorphism may not play a major role in PD in the East Asian populations.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otowa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Shimada
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Xiaoxi
authors.initials: X
authors.lastname: Liu
authors.forename: Ken
authors.initials: K
authors.lastname: Inoue
authors.forename: Nagisa
authors.initials: N
authors.lastname: Sugaya
authors.forename: Takanobu
authors.initials: T
authors.lastname: Minato
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Nakagami
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umekage
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tanii
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Kaiya
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D019208:Brain-Derived Neurotrophic Factor