Association of glycemic control with risk of erectile dysfunction in men with type 2 diabetes.
BACKGROUND
Improvement in glycemic control is likely to reduce the risk of diabetic complication, while its effect on erectile dysfunction (ED) remains unclear.


OBJECTIVE
The aim of this study was to evaluate the association of glycemic control with risk of ED in type 2 diabetics.


METHODS
A self-administered questionnaire containing Sexual Health Inventory for Men was obtained from 792 subjects with type 2 diabetes at our institution. Clinical data were obtained through chart review.


METHODS
The contribution of glycemic control assessed by glycated hemoglobin (HbA(1c)) level as well as age, duration of diabetes, hypertension (HT), dyslipidemia, and cigarette smoking to risk of ED was evaluated.


RESULTS
Of 792 subjects, 83.6% reported having ED and 43.2% had severe ED. HbA(1c) level (%) adjusted for age and duration of diabetes was significantly associated with ED (OR 1.12, 95% CI: 1.01-1.25). None of HT, dyslipidemia, and cigarette smoking was a significant risk factor for ED after adjusted for age and duration of diabetes. HbA(1c) level, age, and duration of diabetes were significant independent risk factors for ED among the younger group (age < or = 60 years), and only age and duration of diabetes were independent risk factors among the older group (age > 60 years). For the risk of severe ED, compared with no and mild to moderate ED, HbA(1c) level, duration of diabetes, and HT were independent risk factors among the younger group, and only age was an independent factor among the older group.


CONCLUSIONS
Better glycemic control probably would reduce the prevalence of ED and its severity among the younger men with type 2 diabetes. For the older group, aging was the major determinant for ED risk among this population with type 2 diabetes.
Lu
Chih-Chen
CC
Department of Internal Medicine, Division of General Medicine, Kaohsiung, Taiwan; Department of Internal Medicine, Division of Endocrinology and Metabolism, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Internal Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Jiann
Bang-Ping
BP
Department of Surgery, Division of Urology, Kaohsiung, Taiwan; Internal Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan. Electronic address: bpjiaan@vghks.gov.tw.
Sun
Chun-Chin
CC
Department of Internal Medicine, Division of Endocrinology and Metabolism, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Internal Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Lam
Hing-Chung
HC
Department of Internal Medicine, Division of Endocrinology and Metabolism, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Internal Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Chu
Chih-Hsun
CH
Department of Internal Medicine, Division of Endocrinology and Metabolism, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Internal Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Rehabilitation Technology, TzuHui Institute of Technology, Pingtung, Taiwan.
Lee
Jenn-Kuen
JK
Department of Pathology and Laboratory Medicine, Division of Biochemistry, Kaohsiung, Taiwan; Department of Internal Medicine, Division of Endocrinology and Metabolism, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Internal Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000453:epidemiology* / Q000378:metabolism; D007172:Erectile Dysfunction / Q000175:diagnosis / Q000453:epidemiology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents