Association study of the serotoninergic system in migraine in the Spanish population.
In order to evaluate the contribution of 19 serotonin-related genes to the susceptibility to migraine in a Spanish population we performed a case-control association study of 122 single nucleotide polymorphisms (SNPs), selected according to genetic coverage parameters, in 528 migraine patients -308 with migraine without aura (MO) and 220 with migraine with aura (MA)- and 528 sex-matched migraine-free controls. The single-marker analysis identified nominal associations with the migraine phenotype or with the MO or MA subtypes. The multiple-marker analysis revealed risk haplotypes in three genes that remained significantly associated with migraine after correction by permutations. Two-marker risk haplotypes were identified in the HTR2B (rs16827801T-rs10194776G) and MAOA (rs3027400G-rs2072743C) genes conferring susceptibility to MO, and a four-marker haplotype in DDC was specific of MA (rs2329340A-rs11974297C-rs2044859T-rs11761683G). The present study supports the involvement of HTR2B and MAOA genes in the genetic predisposition to MO, while DDC might confer susceptibility to MA. These results suggest a differential involvement of serotonin-related genes in the genetic background of MO and MA.
Corominas
R
R
Grup de Recerca en Neurologia Infantil i Psiquiatria Genètica, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Sobrido
M J
MJ
Ribasés
M
M
Cuenca-León
E
E
Blanco-Arias
P
P
Narberhaus
B
B
Roig
M
M
Leira
R
R
López-González
J
J
Macaya
A
A
Cormand
B
B
D016022:Case-Control Studies; D004296:Dopa Decarboxylase / Q000235:genetics; D004843:Epistasis, Genetic; D055106:Genome-Wide Association Study; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*; D008995:Monoamine Oxidase / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D044403:Receptor, Serotonin, 5-HT2B / Q000235:genetics*; D012701:Serotonin / Q000235:genetics*; D013030:Spain
D044403:Receptor, Serotonin, 5-HT2B; D012701:Serotonin; D008995:Monoamine Oxidase; D004296:Dopa Decarboxylase