A new model for the assay of comedolytic activity.
Synopsis An experimental model using the 'Rhino' hairless mouse has been developed for screening comedolytic agents. The skin of this animal presents a high density of spontaneous comedos which appear in histological slices as cystic formations with a large diameter (D) and an open narrow neck (d). The ratio d/D expresses the 'comedo profile'. Statistical evaluation of this value by standardized measurement allows the quantification of comedolytic activity of pharmacological agents.
Bonne
C
C
Secteur de Dermatologie Expérimentale, Laboratoire de Pathologie Expérimentale, Faculté Necker-Enfants Malades, 156 rue de Vaugirard, 75015 Paris.
Zeziola
F
F
Secchi
J
J
Saurat
J H
JH