Host-specificity of Salmonella enterica serovar Gallinarum: insights from comparative genomics.
In this study, we have identified the possible genetic factors responsible for fowl-adaptation of Salmonella entericaserovar Gallinarum (S. Gallinarum). By comparing the genes related to Salmonella pathogenicity islands (SPI) of S. Gallinarum with those of Salmonella entericaserovar Enteritidis (S. Enteritidis) we have identified twenty-four positively selected genes. Our results suggest that the genes encoding the structural components of SPI-2 encoded type three secretion apparatus (TTSS) and the effector proteins that are secreted via SPI-1 encoded TTSS have evolved under positive selection pressure in these serovars. We propose that these positively selected genes play important roles in conferring different host-specificities to S. Gallinarum and S. Enteritidis.
Eswarappa
Sandeepa M
SM
Department of Microbiology and Cell Biology, Centre for Infectious Disease Research and Biosafety Laboratories, Indian Institute of Science, Bangalore, Karnataka, India.
Janice
Jessin
J
Balasundaram
Sudhagar V
SV
Dixit
Narendra M
NM
Chakravortty
Dipshikha
D
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D001715:Bird Diseases / Q000382:microbiology; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D044404:Genomic Islands / Q000235:genetics*; D023281:Genomics; D054884:Host-Pathogen Interactions / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics; D008957:Models, Genetic; D012481:Salmonella Infections, Animal / Q000382:microbiology; D019779:Salmonella enterica / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D012477:Salmonella enteritidis / Q000235:genetics / Q000472:pathogenicity; D012641:Selection, Genetic; D013045:Species Specificity
D001426:Bacterial Proteins; D008565:Membrane Proteins; C440638:SPI-2 protein, Salmonella; C419942:Spi1 protein, Salmonella