title: Kinetics of uranium uptake in soft water and the effect of body size, bioaccumulation and toxicity to Hyalella azteca.
abstract: The kinetics of uptake and the effect of body size on uranium (U) bioaccumulation and toxicity to Hyalella azteca exposed to water-only U concentrations in soft water were evaluated. The effect of body size on U bioaccumulation was significant with a slope of -0.35 between log body concentration and log body mass. A saturation kinetic model was satisfactory to describe the uptake rate, elimination rate and the effect of gut-clearance on size-corrected U bioaccumulation in H. azteca. The one-week lethal water concentrations causing 50% mortality for juvenile and adult H. azteca were 1100 and 4000 nmol U/L, respectively. The one-week lethal body concentration causing 50% mortality was 140 nmol U/g for juvenile H. azteca and 220 nmol U/g for adult H. azteca. One-week bioaccumulation studies that properly account for body-size and gut-clearance times can provide valuable data on U bioavailability and toxicity in the environment.
authors.affiliation: Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
authors.forename: L C
authors.initials: LC
authors.lastname: Alves
authors.forename: U
authors.initials: U
authors.lastname: Borgmann
authors.forename: D G
authors.initials: DG
authors.lastname: Dixon
mesh_terms: D033304:Amphipoda / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D049628:Body Size; D007700:Kinetics; D014501:Uranium / Q000378:metabolism* / Q000633:toxicity; D014867:Water / Q000737:chemistry*; D014875:Water Pollutants, Radioactive / Q000378:metabolism* / Q000633:toxicity
chemical_list: D014875:Water Pollutants, Radioactive; D014867:Water; D014501:Uranium