title: [Study on optimization of formulation and preparation process of sinomenine liposomes].
abstract: OBJECTIVE
  To optimize the formulation and preparation process of sinomenine liposomes.
  
  
  METHODS
  Method of aether injection and mixture uniform design were adopted to determine the formulation of sinomenine liposomes is the proportion of phospholipids, cholesterol and Vitamin E with the index of entrapment efficiency. And the single-factor test was used to study the preparation process of the liposomes, including the volume of buffer solution, the preparation temperature and the ultrasonic time.
  
  
  RESULTS
  The optimized formulation was that the ratio of sinomenine : phospholipids : cholesterol : vitamin E mass ratio was 8.92 : 60.35 : 28.81 : 1.91. The volume of buffer solution was 50 mL x g(-1) membrane, the preparation temperature was 50 degrees C, and the ultrasonic time was 20 min.
  
  
  CONCLUSIONS
  Satisfactory shape and entrapment efficiency of the liposomes can be obtained by the optimized formulation and preparation process.
authors.affiliation: Section of Chinese Pharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China. gdpuwy@126.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhenna
authors.initials: Z
authors.lastname: Cong
authors.forename: Qingfei
authors.initials: Q
authors.lastname: Liu
authors.forename: Jiajun
authors.initials: J
authors.lastname: Ling
authors.forename: Liling
authors.initials: L
authors.lastname: Zhou
mesh_terms: D002626:Chemistry, Pharmaceutical; D002784:Cholesterol; D004304:Dosage Forms; D004337:Drug Carriers; D004339:Drug Compounding / Q000191:economics / Q000379:methods; D016503:Drug Delivery Systems; D004355:Drug Stability; D008081:Liposomes; D009019:Morphinans / Q000493:pharmacokinetics*; D010316:Particle Size; D010743:Phospholipids; D013678:Technology, Pharmaceutical
chemical_list: D004304:Dosage Forms; D004337:Drug Carriers; D008081:Liposomes; D009019:Morphinans; D010743:Phospholipids; C009271:sinomenine; D002784:Cholesterol