Preparation of the different derivatives of the low-molecular-weight porphyran from Porphyra haitanensis and their antioxidant activities in vitro.
Porphyran extracted from Porphyra haitanensis is a sulfated polysaccharide, which possesses excellent antioxidant activities. In this study, we prepared one low-molecular-weight porphyran and its sulfated, acetylated, phosphorylated and benzoylated derivatives. Their antioxidant activities were investigated including scavenging effect of superoxide, hydroxyl and 1,1-diphenyl-2-picrylhydrazyl radicals. The results of chemical analysis and FT-IR spectrums showed the modification was successful. And in addition, we found that certain derivative exhibited stronger antioxidant activity than low-molecular-weight porphyran. The benzoylated derivative showed the most excellent antioxidant activity in three assays, so this derivative needs to be attended to.
Zhang
Zhongshan
Z
Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Zhang
Quanbin
Q
Wang
Jing
J
Zhang
Hong
H
Niu
Xizhen
X
Li
Pengcheng
P
D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D002681:China; D017665:Hydroxyl Radical / Q000378:metabolism; D010851:Picrates / Q000378:metabolism; D044664:Porphyra / Q000737:chemistry*; D012685:Sepharose / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013481:Superoxides / Q000378:metabolism
D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; C038549:porphyran; D013481:Superoxides; D017665:Hydroxyl Radical; D012685:Sepharose; C004931:1,1-diphenyl-2-picrylhydrazyl