Chronic dietary exposure to environmental organochlorine contaminants induces thyroid gland lesions in Arctic foxes (Vulpes lagopus).
The impact of dietary organochlorine (OC) exposure on thyroid gland pathology was studied in farmed male Arctic foxes (Vulpes lagopus). The exposed group (n=16) was fed a diet based on wild minke whale (Balaenoptera acutorostrata) blubber as a main fat source in order to mimic the exposure to OC cocktails in the Artic environment. This resulted in an exposure of approximately 17 microg Sigma OC/kg day and a Sigma OC residue adipose tissue and liver concentration of 1700 and 4470 ng/gl.w., respectively, after 16 months of exposure. Control foxes (n=13) were fed a diet with pork (Sus scrofa) fat as a main fat source containing significantly lower OC concentrations. The food composition fed to the control and exposed group was standardized for nutrient contents. Four OC-related histopathological changes were found: (1) flat-epithelial-cell true thyroid cysts (TC) characterized by neutral content; (2) remnants of simple squamous epithelial-cell embryonic ducts containing neutral debris (EDN); (3) remnants of stratified squamous epithelial-cell embryonic ducts containing acid mucins often accompanied with debris of leukocyte inflammatory nature (EDM) and (4) disseminated thyroid C-cell hyperplasia (HPC). Of these, the prevalence of TC, EDN and HPC was significantly highest in the exposed group (chi(2) test: all p<0.04). The study shows that the OC mixture in minke whale blubber may cause development of thyroid gland cysts, C-cell hyperplasia and increase the prevalence of cystic remnants of embryonic ducts. The mechanism causing these effects could include endocrine disruption of the hypothalamus-pituitary-thyroid (HPT) axis, a disturbance of the calcium homeostasis/metabolism or energy metabolism or immune suppression. Because concentrations of OCs are higher in wild Arctic foxes, it is likely that these animals could suffer from similar OC-induced thyroid gland pathological and functional changes.
Sonne
Christian
C
Section for Contaminants, Effects and Marine Mammals, Department of Arctic Environment, National Environmental Research Institute, Aarhus University, Frederiksborgvej 399, PO Box 358, DK-4000 Roskilde, Denmark. csh@dmu.dk
Wolkers
Hans
H
Leifsson
Pall S
PS
Iburg
Tine
T
Jenssen
Bjørn Munro
BM
Fuglei
Eva
E
Ahlstrøm
Oystein
O
Dietz
Rune
R
Kirkegaard
Maja
M
Muir
Derek C G
DC
Jørgensen
Even H
EH
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D004032:Diet / Q000592:standards; D004041:Dietary Fats / Q000032:analysis; D052244:Endocrine Disruptors / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D004734:Energy Metabolism / Q000187:drug effects; D004785:Environmental Pollutants / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D020387:Food Chain; D005589:Foxes / Q000254:growth & development* / Q000378:metabolism; D006843:Hydrocarbons, Chlorinated / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D008297:Male; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D004041:Dietary Fats; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated