[Effects of collagen matrices by covalent incorporation of heparin and loading with huangqi injection (HI) on anagenetic blood vessel].
To investigate effects of collagen matrices by covalent incorporation of heparin and loading with huangqi injection (HI) on anagenetic capillaries, we established the chick chorioallantois model. The collagen matrices by covalent incorporation of heparin and loading with HI were placed and then the eggs were continuously incubated for 3 days. The number of capillaries in the vicinity of samples, the hemoglobin content inside the samples, the dry weight and the macroscopic observation were evaluated. We found the heparinized matrices had comparable angiogenic effects. The number of capillaries, the hemoglobin content, the expression of CD34 increased remarkably (P < 0.01). So we concluded that HI might be considered as an alternative or addition agent to promote the acidification of capillaries.
Yan
Shihai
S
Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China. yhhy0210@yahoo.com.cn
Zhu
Xuanxuan
X
Chen
Xiaohu
X
Li
Qiyi
Q
Gong
Ren
R
Yao
Chang
C
Zhu
Changle
C
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology; D002196:Capillaries / Q000187:drug effects / Q000378:metabolism; D002642:Chick Embryo; D003094:Collagen / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D006493:Heparin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007267:Injections
D004365:Drugs, Chinese Herbal; C439205:Huangqin-Tang; D006493:Heparin; D003094:Collagen