Synthesis and antimicrobial evaluation of bile acid tridentate conjugates.
Two series of novel bile acid tridentate conjugates with different linkers were synthesized and characterized, and their biological activities in vitro were evaluated. The procedure was straightforward and efficient to be carried out with high overall yield. The antimicrobial activity of the synthesized compounds against Saccharomyces cerevisiae, Aspergillus niger, Escherichia coli and Staphylococcus aureus was investigated in vitro. The best activity of minimal inhibitory concentrations (MICs) for 1c, 1c', 2c and 2c' against S. cerevisiae was up to 0.125 microg/mL.
Huang
Liliang
L
Radiopharmaceuticals Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
Sun
Yanhong
Y
Zhu
Hua
H
Zhang
Yuanqing
Y
Xu
Jia
J
Shen
Yu-Mei
YM
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001647:Bile Acids and Salts / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D001647:Bile Acids and Salts