title: Chronic myelogenous leukemia showing biphenotypic blast crisis followed by lineage switch to B lymphoblastic leukemia.
abstract: Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three cases of lineage switch between lymphoid and myeloid/myelomonocytic lineages have been reported in the literature. Here, we report a novel case of imatinib-resistant CML-BC, in which the blast lineage switched from biphenotypic to B-lymphoid.
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Oh
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
authors.forename: Hye Ran
authors.initials: HR
authors.lastname: Kim
authors.forename: Ja Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Jeong Hwan
authors.initials: JH
authors.lastname: Shin
authors.forename: Jeong Nyeo
authors.initials: JN
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D001752:Blast Crisis; D001853:Bone Marrow / Q000473:pathology; D019070:Cell Lineage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015448:Leukemia, B-Cell / Q000473:pathology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D008297:Male