title: Advanced stomach and pancreas cancer successfully treated with combination chemotherapy with S-1/paclitaxel/lentinan.
abstract: We report a case of stomach and pancreas cancers that showed marked responses to combination chemotherapy consisting of S-1, paclitaxel (PTX), and lentinan (LNT). A 67-year-old Japanese man was referred to our hospital in July 2005, diagnosed with advanced gastric cancer. Subsequent examination revealed the existence of cancers in the stomach and pancreas, with lymph nodes and peritoneal metastasis and ascites. The patient received combined chemotherapy (one course comprised 3 weeks) with S-1 (100 mg/body, day 1-14 followed by withdrawal for 1 week), PTX (50 mg/m2, day 1 and day 8), and LNT (2 mg/m2, day 1, day 8 and day 15). After completion of 4 courses, the patient achieved partial response (PR), with complete disappearance of the primary gastric tumor and ascites. He maintained in PR for 17 months. We analyzed Th1/ Th2 ratio and LNT binding rate to monocytes by flow cytometry. Combination chemotherapy with S-1/PTX/LNT can be an effective treatment for unresectable advanced gastric carcinoma.
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Kubota
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Kazuki
authors.initials: K
authors.lastname: Hayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamiya
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Naotaka
authors.initials: N
authors.lastname: Ogasawara
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yamada
authors.forename: Tsuneya
authors.initials: T
authors.lastname: Wada
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mori
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Mizoshita
authors.forename: Takaya
authors.initials: T
authors.lastname: Shimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Mizushima
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ohara
authors.forename: Takashi
authors.initials: T
authors.lastname: Joh
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D017239:Paclitaxel