Cumulative delivery rate in an in vitro fertilization program with a single embryo transfer policy.
OBJECTIVE
To investigate the cumulative delivery rate for women completing three fresh embryo transfer cycles or giving birth after the first or second transfer cycle in an in vitro fertilization program with a single embryo transfer (SET) policy.


METHODS
Privately run infertility clinic in southern Sweden (Skåne region).


METHODS
Four hundred fifty-three consecutive, unselected public patients beginning an ovum pick-up cycle between July 2002 and June 2004.


METHODS
Retrospective, observational study.


METHODS
Cumulative delivery rates.


RESULTS
Of 370 women who completed the study with up to three fresh ET cycles (90% SETs), 244 women (66%) progressed to delivery. Among the deliveries were three sets of twins (1%), one dizygotic. Cumulative delivery rates showed significant differences relative to age <36 (71%) and >or=36 years (47%), and delivery rates relative to rank of ET cycle (first and second vs. third ET cycle - 35, 34, and 21% delivery rates, respectively).


CONCLUSIONS
The 66% cumulative delivery rate is in accordance with rates in similar observational studies and in estimation studies, in which predominantly two embryos were used for transfer. The multiple delivery rate was low. We suggest that repeated SET cycles can be implemented on a large scale even in a primarily unselected patient population without compromising the outcome.
Sundström
Per
P
IVF clinic Cura, Malmo, Sweden.
Saldeen
Pia
P
D000328:Adult; D036861:Delivery, Obstetric / Q000706:statistics & numerical data*; D004624:Embryo Transfer / Q000706:statistics & numerical data*; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D013548:Sweden / Q000453:epidemiology