Telomere capture in hepatitis C infection.
Broken chromosomes can acquire new telomeres by "telomere capture" (TC), and it has become possible to investigate the terminus in cytogenetically visible telomere rearrangements. The TC phenomenon was observed in malignant conditions. We evaluated the TC rate in hepatitis C virus (HCV) patients compared to non-Hodgkin's lymphoma patients, as well as relative to a control group. For this purpose, we used two Cytocell probes, 15qter and 13qter. Higher TC rates were found in the three study groups relative to the control group. Our results showed that HCV patients have some of the components that can initiate the cascade of events leading to malignancies.
Goldberg-Bittman
Lilach
L
Genetic Institute, Meir Hospital, Kfar Saba 44281, Israel; Faculty of Life Science, Bar-Ilan University, Ramat Gan, Israel.
Amiel
Aliza
A
Hadary
Ruth
R
Fejgin
Moshe D
MD
Quitt
Miriam
M
Kitay-Cohen
Yona
Y
D018929:Cell Culture Techniques; D043171:Chromosomal Instability / Q000235:genetics*; D002877:Chromosomes, Human; D006526:Hepatitis C / Q000235:genetics / Q000473:pathology*; D019698:Hepatitis C, Chronic / Q000235:genetics / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000166:cytology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology*; D011995:Recombination, Genetic; D012016:Reference Values; D016615:Telomere / Q000235:genetics* / Q000473:pathology*; D014178:Translocation, Genetic