Cellular targets of estrogen signaling in regeneration of inner ear sensory epithelia.
Estrogen signaling in auditory and vestibular sensory epithelia is a newly emerging focus propelled by the role of estrogen signaling in many other proliferative systems. Understanding the pathways with which estrogen interacts can provide a means to identify how estrogen may modulate proliferative signaling in inner ear sensory epithelia. Reviewed herein are two signaling families, EGF and TGFbeta. Both pathways are involved in regulating proliferation of supporting cells in mature vestibular sensory epithelia and have well characterized interactions with estrogen signaling in other systems. It is becoming increasingly clear that elucidating the complexity of signaling in regeneration will be necessary for development of therapeutics that can initiate regeneration and prevent progression to a pathogenic state.
McCullar
Jennifer S
JS
Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, University of Washington, CHDD CD176, P.O. Box 357923, Seattle, WA 98195, USA.
Oesterle
Elizabeth C
EC
D000818:Animals; D049109:Cell Proliferation; D007758:Ear, Inner / Q000502:physiology*; D053595:Embryonic Stem Cells / Q000502:physiology; D004815:Epidermal Growth Factor / Q000502:physiology; D066246:ErbB Receptors / Q000502:physiology; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D011960:Receptors, Estrogen / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D015398:Signal Transduction; D016211:Transforming Growth Factor alpha / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology
D004967:Estrogens; D011960:Receptors, Estrogen; D016211:Transforming Growth Factor alpha; D016212:Transforming Growth Factor beta; D004815:Epidermal Growth Factor; D066246:ErbB Receptors