Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
Perry
John R B
JR
Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK.
Stolk
Lisette
L
Franceschini
Nora
N
Lunetta
Kathryn L
KL
Zhai
Guangju
G
McArdle
Patrick F
PF
Smith
Albert V
AV
Aspelund
Thor
T
Bandinelli
Stefania
S
Boerwinkle
Eric
E
Cherkas
Lynn
L
Eiriksdottir
Gudny
G
Estrada
Karol
K
Ferrucci
Luigi
L
Folsom
Aaron R
AR
Garcia
Melissa
M
Gudnason
Vilmundur
V
Hofman
Albert
A
Karasik
David
D
Kiel
Douglas P
DP
Launer
Lenore J
LJ
van Meurs
Joyce
J
Nalls
Michael A
MA
Rivadeneira
Fernando
F
Shuldiner
Alan R
AR
Singleton
Andrew
A
Soranzo
Nicole
N
Tanaka
Toshiko
T
Visser
Jenny A
JA
Weedon
Michael N
MN
Wilson
Scott G
SG
Zhuang
Vivian
V
Streeten
Elizabeth A
EA
Harris
Tamara B
TB
Murray
Anna
A
Spector
Tim D
TD
Demerath
Ellen W
EW
Uitterlinden
André G
AG
Murabito
Joanne M
JM
D000293:Adolescent; D000367:Age Factors; D015992:Body Mass Index; D002648:Child; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D008572:Menarche / Q000235:genetics*; D015201:Meta-Analysis as Topic; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins; D012741:Sexual Maturation / Q000235:genetics
D004268:DNA-Binding Proteins; C516326:LIN28B protein, human; D016601:RNA-Binding Proteins