title: Molecular epidemiological study on prevalence of human papillomaviruses in patients with common warts in Beijing area.
abstract: OBJECTIVE
  To study the circulation, distribution, and genomic diversity of HPVs in common warts in Beijing area of China.
  
  
  METHODS
  Forty eight patients with pathologically diagnosed common warts were screened for the presence of HPV with HPV type-specific PCR and direct sequencing analysis. The genomic diversity of HPVs prevalent in Chinese patients was analyzed based on LCR.
  
  
  RESULTS
  Forty one (85.5%) samples were positive for HPV DNA, 13 (31.7%)--HPV-57, 12 (29.3%)--HPV-1a, 7 (17%)--HPV-27 and 5(12.2%)--HPV-2a. Four cases were infected with two different HPV types, two (4.9%) with HPV-1a and HPV-27, one (2.4%) with HPV-1 and HPV-57 and one (2.4%) with HPV-27 and HPV-57. In contrast to the prevalence of single strain of novel HPV-57 variant and HPV-1 prototype, two HPV-2 and three HPV-27 novel variants were found to circulate in Beijing.
  
  
  CONCLUSIONS
  HPV-1, -2, -27 and -57 are predominantly prevalent in patients with common warts in Beijing.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Lei
authors.forename: Chen
authors.initials: C
authors.lastname: Gao
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Han
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Chen
authors.forename: Guang-Cai
authors.initials: GC
authors.lastname: Xiang
authors.forename: Qi
authors.initials: Q
authors.lastname: Shi
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Run
authors.initials: R
authors.lastname: An
authors.forename: Chen-Fang
authors.initials: CF
authors.lastname: Dong
authors.forename: Yu-Kang
authors.initials: YK
authors.lastname: Yuan
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Dong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D004279:DNA, Viral; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010802:Phylogeny; D015995:Prevalence; D014860:Warts / Q000453:epidemiology* / Q000821:virology
chemical_list: D004279:DNA, Viral