title: Histological evaluation of the effect of three medicaments;  trichloracetic acid, formocresol and mineral trioxide aggregate  on pulpotomised teeth of dogs.
abstract: The aim of this study was to use clinical, radiographic and histological examinations to compare the dental pulp response in 162 premolar roots of eight dogs when trichloracetic acid (TCA), formocresol, mineral trioxide aggregate (MTA) and zinc oxide eugenol were used as pulpotomy agents. The teeth were divided into four groups. Following pulpotomy, the teeth were restored with amalgam. The animals were sacrificed at 48 h, 2, 4 and 8 weeks (two dogs at each interval). Histological evaluation indicated no cases with necrosis. After 8 weeks follow up, dentine bridge formation was evident in 20%, 50% and 91.7% of formocresol, TCA and MTA cases respectively. The first signs of bridge formation were seen for MTA at 2 weeks and for TCA at 4 weeks. MTA was superior to formocresol and TCA in treating pulps in dogs. However, bridge formation was seen in 50% of TCA cases after 8 weeks which is a desirable finding in pulpotomy procedures.
authors.affiliation: Department of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. b64karami@yahoo.com
authors.forename: Babak
authors.initials: B
authors.lastname: Karami
authors.forename: Akbar
authors.initials: A
authors.lastname: Khayat
authors.forename: Fariborz
authors.initials: F
authors.lastname: Moazami
authors.forename: Soheil
authors.initials: S
authors.lastname: Pardis
authors.forename: Paul
authors.initials: P
authors.lastname: Abbott
mesh_terms: D017607:Aluminum Compounds / Q000494:pharmacology; D000818:Animals; D017610:Calcium Compounds / Q000494:pharmacology; D003782:Dental Pulp / Q000187:drug effects* / Q000378:metabolism; D003809:Dentin, Secondary / Q000378:metabolism*; D004285:Dogs; D004338:Drug Combinations; D005566:Formocresols / Q000494:pharmacology; D009804:Odontoblasts; D010087:Oxides / Q000494:pharmacology; D011671:Pulpitis / Q000139:chemically induced; D011672:Pulpotomy / Q000379:methods*; D012388:Root Canal Irrigants / Q000494:pharmacology*; D017640:Silicates / Q000494:pharmacology; D014238:Trichloroacetic Acid / Q000494:pharmacology; D015035:Zinc Oxide-Eugenol Cement / Q000494:pharmacology
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D005566:Formocresols; D010087:Oxides; D012388:Root Canal Irrigants; D017640:Silicates; D015035:Zinc Oxide-Eugenol Cement; C086631:mineral trioxide aggregate; C031025:formocresol; D014238:Trichloroacetic Acid