title: Phenoxypropylamines: synthesis and antiulcer evaluation.
abstract: We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, (1)H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of themshowed significant gastric acid antisecretory activity.
authors.affiliation: College of Sciences, Northeastern University, Shenyang, China. a13998826073@163.com
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Bao-Yan
authors.initials: BY
authors.lastname: Zhang
authors.forename: Qian-Yun
authors.initials: QY
authors.lastname: Zhang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhao
authors.forename: Jia-Mei
authors.initials: JM
authors.lastname: Wang
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism; D006168:Guinea Pigs; D006635:Histamine H2 Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000588:Amines; D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D010880:Piperidines; C053742:roxatidine acetate