title: Rapid decline in 51Cr-EDTA measured renal function during the first weeks following lung transplantation.
abstract: We previously described a 54% decline in renal function at 6 months after lung transplantation (LTx). We hypothesized that this decline is a very early event following LTx. Thirty-one consecutive patients (16 females/15 males), mean age 49 (+/-13) years, with emphysema, cystic fibrosis/bronchiectasis or idiopathic pulmonary fibrosis were included in an analysis of renal function before and after LTx. The glomerular filtration rate (GFR) was measured using the (51)Cr-ethylenediaminetetra acetic acid plasma clearance single injection technique (mGFR) at baseline before transplantation and at 1, 2, 3 and 12 weeks postoperatively. Mean mGFR declined from 103 +/- 18 to 65 +/- 22, 53 +/- 16 and 57 +/- 18 mL/min/1.73m(2) at 1-, 3- and 12-weeks post-LTx (p < 0.0001), respectively. In a time-dependent repeated measures ANOVA, risk factors for a decline in mGFR posttransplant included: time (p < 0.0001), acute renal failure within 2 weeks post-LTx (p = 0.0003), use of heart and lung machine (p = 0.04), and the use of ephedrine (p = 0.048), as well as increasing age, older than 18 years at LTx (p = 0.006). These data demonstrate that renal function, measured with an isotope method, decreases dramatically during the first week after LTx.
authors.affiliation: Department of Nephrology, University of Copenhagen, Copenhagen, Denmark. mads.hornum@rh.regionh.dk
authors.forename: M
authors.initials: M
authors.lastname: Hornum
authors.forename: M
authors.initials: M
authors.lastname: Iversen
authors.forename: I
authors.initials: I
authors.lastname: Steffensen
authors.forename: P
authors.initials: P
authors.lastname: Hovind
authors.forename: J
authors.initials: J
authors.lastname: Carlsen
authors.forename: L W
authors.initials: LW
authors.lastname: Andersen
authors.forename: D A
authors.initials: DA
authors.lastname: Steinbrüchel
authors.forename: B
authors.initials: B
authors.lastname: Feldt-Rasmussen
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D002860:Chromium Radioisotopes; D004492:Edetic Acid; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D002860:Chromium Radioisotopes; D004492:Edetic Acid