title: First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy.
abstract: A qnrS1-positive strain of Escherichia coli was detected among 73 poultry isolates showing ciprofloxacin MICs of > or =0.125 microg/ml. The qnrS1 gene was associated with a Tn3-like transposon, as previously described to occur in a Salmonella enterica serovar Infantis strain of animal origin, but the plasmid scaffold carrying this element resembled that of a plasmid previously identified in Salmonella enterica serovar Dublin. These elements suggest genetic exchanges among Salmonella and E. coli and a potential animal reservoir for the qnr genes.
authors.affiliation: Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Cerquetti
authors.forename: Aurora
authors.initials: A
authors.lastname: García-Fernández
authors.forename: Maria
authors.initials: M
authors.lastname: Giufrè
authors.forename: Daniela
authors.initials: D
authors.lastname: Fortini
authors.forename: Marisa
authors.initials: M
authors.lastname: Accogli
authors.forename: Caterina
authors.initials: C
authors.lastname: Graziani
authors.forename: Ida
authors.initials: I
authors.lastname: Luzzi
authors.forename: Alfredo
authors.initials: A
authors.lastname: Caprioli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Carattoli
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D005798:Genes, Bacterial / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics*; D011200:Poultry; D011201:Poultry Diseases / Q000382:microbiology*; D015363:Quinolones / Q000494:pharmacology*; D019779:Salmonella enterica / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones; D002939:Ciprofloxacin