[Screening for relevant proteins involved in adhesion of Cryptosporidium parvum sporozoites to host cells].
The Cryptosporidium parvum T7 phage display library was screened by using Caco-2 cells. Five specific gene fragments were identified by blasting sequences in GenBank, one of which encoding the CP2 protein was previously identified as a surface molecule of sporozoites and involved in parasite invasion. The others are hypothetic proteins with unknown functions. Bioinformatic analysis of these proteins indicated that they may be involved in the host-parasite interactions.
Guo
An
A
Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun 130062, China.
Yin
Ji-gang
JG
Xiang
Mei
M
Liu
Xian-ying
XY
Zhang
Yan
Y
Chen
Qi-jun
QJ
D000818:Animals; D018938:Caco-2 Cells; D016785:Cryptosporidium parvum / Q000235:genetics*; D015723:Gene Library; D006790:Host-Parasite Interactions; D006801:Humans; D019151:Peptide Library; D015800:Protozoan Proteins / Q000235:genetics*
D019151:Peptide Library; D015800:Protozoan Proteins