title: The CULt of caspase-8 ubiquitination.
abstract: Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.
authors.affiliation: Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Miklós
authors.initials: M
authors.lastname: Békés
authors.forename: Guy S
authors.initials: GS
authors.lastname: Salvesen
mesh_terms: D017209:Apoptosis; D053181:Caspase 8 / Q000378:metabolism*; D044842:Cullin Proteins / Q000378:metabolism*; D053418:Death Domain Receptor Signaling Adaptor Proteins / Q000378:metabolism; D006801:Humans; D054875:Ubiquitination
chemical_list: C503645:CUL3 protein, human; D044842:Cullin Proteins; D053418:Death Domain Receptor Signaling Adaptor Proteins; D053181:Caspase 8