title: Polycations. 17. Synthesis and properties of polycationic derivatives of carbohydrates.
abstract: In our continuing investigation of polycationic salts for purposes of antimicrobial action, ion-channel blocking, and construction of ionic liquids, we have prepared several series of polycationic salts derived from carbohydrate precursors. These salts are currently being investigated for optimal efficacy as antibacterials and antifungals, as well as for other applications. The syntheses of such series of salts are described here along with preliminary antibacterial testing results and a discussion of their properties indicating their potential utility for several purposes.
authors.affiliation: Department of Chemistry and Biochemistry, Queens College CUNY, 65-30 Kissena Boulevard, Flushing, NY 11367, USA.
authors.forename: Marie
authors.initials: M
authors.lastname: Thomas
authors.forename: Diego
authors.initials: D
authors.lastname: Montenegro
authors.forename: Alejandra
authors.initials: A
authors.lastname: Castaño
authors.forename: Laura
authors.initials: L
authors.lastname: Friedman
authors.forename: Jay
authors.initials: J
authors.lastname: Leb
authors.forename: Mia Lace
authors.initials: ML
authors.lastname: Huang
authors.forename: Leah
authors.initials: L
authors.lastname: Rothman
authors.forename: Heidi
authors.initials: H
authors.lastname: Lee
authors.forename: Craig
authors.initials: C
authors.lastname: Capodiferro
authors.forename: Daniel
authors.initials: D
authors.lastname: Ambinder
authors.forename: Eva
authors.initials: E
authors.lastname: Cere
authors.forename: Jessica
authors.initials: J
authors.lastname: Galante
authors.forename: JaimeLee
authors.initials: J
authors.lastname: Rizzo
authors.forename: Karin
authors.initials: K
authors.lastname: Melkonian
authors.forename: Robert
authors.initials: R
authors.lastname: Engel
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D005782:Gels; D005960:Glucosides / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013402:Sugar Alcohols / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D005782:Gels; D005960:Glucosides; D013402:Sugar Alcohols