title: Ciprofloxacin-induced torsades de pointes in a methadone-dependent patient.
abstract: ABSTRACT Background Methadone has been associated with QT prolongation and Torsades de pointes. Ciprofloxacin may prolong QT interval and induce Torsades de pointes when other risk factors are present. Case description A case is described in which a patient receiving methadone treatment developed Torsades de pointes following the addition of ciprofloxacin. Conclusion Ciprofloxacin should be used with caution in patients receiving methadone.
authors.affiliation: Department of Internal Medicine, Mount Sinai School of Medicine, Elmhurst Hospital Center, New York, NY 11373, USA. mknairmd@gmail.com
authors.forename: Murali K
authors.initials: MK
authors.lastname: Nair
authors.forename: Krunal
authors.initials: K
authors.lastname: Patel
authors.forename: Perry J
authors.initials: PJ
authors.lastname: Starer
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008691:Methadone / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009294:Narcotics / Q000009:adverse effects* / Q000627:therapeutic use; D015819:Substance Abuse, Intravenous / Q000534:rehabilitation*; D016171:Torsades de Pointes / Q000139:chemically induced*
chemical_list: D000890:Anti-Infective Agents; D009294:Narcotics; D002939:Ciprofloxacin; D008691:Methadone