title: Reduced angiogenesis and delay in wound healing in angiotensin II type 1a receptor-deficient mice.
abstract: Angiotensin II (Ang II) is a bioactive peptide that plays important roles in blood pressure regulation and salt-water homeostasis. Recently, Ang II was reported to function in the promotion of angiogenesis. Since the wound healing process is highly dependent upon angiogenesis, we employed Ang II receptor knockout mice (AT1a(-/-)) to investigate whether or not Ang II facilitates angiogenesis and wound healing via AT1a receptor signaling. In comparison to wild-type (WT) mice, wound healing and wound-induced angiogenesis were significantly suppressed in AT1a(-/-) mice, and these mice exhibited reduced expression of CD31 in wound granulation tissues. In comparison to vehicle-treated mice, wound healing was delayed significantly in mice treated with an AT1-R antagonist and this delay was accompanied by the reduced expression of vascular endothelial growth factor in wound granulation tissues. These findings suggest that Ang II-AT1a signaling plays a crucial role in wound healing and wound-induced angiogenesis.
authors.affiliation: Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: Maya
authors.initials: M
authors.lastname: Kurosaka
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kanako
authors.initials: K
authors.lastname: Hosono
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kamata
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Fukamizu
authors.forename: Hidero
authors.initials: H
authors.lastname: Kitasato
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Fujita
authors.forename: Masataka
authors.initials: M
authors.lastname: Majima
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000818:Animals; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018919:Neovascularization, Physiologic; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D044140:Receptor, Angiotensin, Type 1 / Q000032:analysis / Q000502:physiology*; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000502:physiology; D014945:Wound Healing
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D044140:Receptor, Angiotensin, Type 1; D042461:Vascular Endothelial Growth Factor A