title: [Antenatal prediction of pulmonary hypoplasia and intrauterine treatment by endoscopic fetal tracheal occlusion in severe isolated congenital diaphragmatic hernia].
abstract: Congenital diaphragmatic hernia (CDH) affects one in 2500 to 5000 births and can be detected in utero by means of ultrasound screening Associated structural problems aggravate the prognosis. The survival rate is 70% or more for cases managed in tertiary care centers. The commonest causes of neonatal death in this setting are pulmonary hypoplasia and pulmonary hypertension. Prenatal imaging findings can now accurately predict postnatal outcome, based mainly on ultrasound determination of the lung-to-head ratio and liver position. This information can be used to counsel patients. In severe cases, prenatal intervention can reverse pulmonary hypoplasia. We review current data on prenatal prediction of neonatal survival. We also discuss experimental and clinical data on the benefits of fetal tracheal occlusion. The TOTAL trial (Tracheal Occlusion To Accelerate Lung growth) is currently ongoing in Europe.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Gucciardo
authors.forename: Jan A
authors.initials: JA
authors.lastname: Deprest
authors.forename: Pascal
authors.initials: P
authors.lastname: Vaast
authors.forename: Romain
authors.initials: R
authors.lastname: Favre
authors.forename: Denis
authors.initials: D
authors.lastname: Gallot
authors.forename: Cyril
authors.initials: C
authors.lastname: Huissoud
authors.forename: Florence
authors.initials: F
authors.lastname: Bretelle
authors.forename: Joel
authors.initials: J
authors.lastname: Agenor
authors.forename: Alexandra
authors.initials: A
authors.lastname: Benachi
authors.forename: Jacques
authors.initials: J
authors.lastname: Jani
authors.forename: Elise
authors.initials: E
authors.lastname: Done
authors.forename: Tim
authors.initials: T
authors.lastname: van Mieghem
authors.forename: Yves
authors.initials: Y
authors.lastname: Ville
authors.forename: Roland
authors.initials: R
authors.lastname: Devlieger
mesh_terms: D000818:Animals; D002404:Catheterization / Q000379:methods; D002986:Clinical Trials as Topic; D005332:Fetoscopy; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000000981:diagnostic imaging / Q000196:embryology / Q000601:surgery*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D021621:Imaging, Three-Dimensional; D007231:Infant, Newborn; D008168:Lung / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000196:embryology / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D009929:Organ Size; D017410:Practice Guidelines as Topic; D011296:Prenatal Diagnosis / Q000379:methods*; D011817:Rabbits; D051381:Rats; D012720:Severity of Illness Index; D014132:Trachea / Q000196:embryology / Q000601:surgery*; D016216:Ultrasonography, Prenatal