Secondary tumoural valvulopathy in a dog.
This short report describes a case of tricuspid valvular metastasis of canine disseminated histiocytic sarcoma in a 9-year-old female Rottweiler. Immunohistochemically the malignant neoplastic cells gave a strong reaction for vimentin and lysozyme, and showed negativity for serotonin, CD3, CD79a and cytokeratin. The intratumoural microvessels were detected by immunohistochemistry using CD31 and claudin-5. This appears to be the first report of a valvular metastasis of canine malignant histiocytosis.
Jakab
Csaba
C
Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Medicine, Szent István University, István u. 2, H-1078 Budapest, Hungary. Jakab.Csaba@aotk.szie.hu
Szász
Attila Marcell
AM
Kulka
Janina
J
Baska
Ferenc
F
Rusvai
Miklós
M
Gálfi
Péter
P
Németh
Tibor
T
D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006338:Heart Neoplasms / Q000556:secondary / Q000662:veterinary*; D054747:Histiocytic Sarcoma / Q000473:pathology / Q000662:veterinary*; D014261:Tricuspid Valve / Q000473:pathology