A general strategy for the preparation of C-terminal peptide alpha-ketoacids by solid phase peptide synthesis.
A new cyanosulfur-ylide based linker makes possible the synthesis of C-terminal peptide alpha-ketoacids by solid phase synthesis. The preparation of the requisite linker and its application to a variety of C-terminal peptide alpha-ketoacids with unprotected side chains is reported.
Ju
Lei
L
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Bode
Jeffrey W
JW
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007651:Keto Acids / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry
D007651:Keto Acids; D009570:Nitriles; D010455:Peptides; D013876:Thiophenes