title: A general strategy for the preparation of C-terminal peptide alpha-ketoacids by solid phase peptide synthesis.
abstract: A new cyanosulfur-ylide based linker makes possible the synthesis of C-terminal peptide alpha-ketoacids by solid phase synthesis. The preparation of the requisite linker and its application to a variety of C-terminal peptide alpha-ketoacids with unprotected side chains is reported.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Ju
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Bode
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007651:Keto Acids / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry
chemical_list: D007651:Keto Acids; D009570:Nitriles; D010455:Peptides; D013876:Thiophenes