title: [Effect of volatile oil from nutmeg on liver microsomal cytochrome P450 in mice].
abstract: OBJECTIVE
  To study the effect of the volatile oil from nutmeg on liver microsomal cytochrome P450 in mice.
  
  
  METHODS
  Mice were administered the volatile oil from nutmeg at 0.4, 0.8 and 1.2 mg x g(-1), respectively, twice a day for 10 days. And then, the contents of liver microsomal cytochrome P450 (CYP), cytochrome b5 (Cytb5), MDA and GST in serum were examined by UV chromatography method.
  
  
  RESULTS
  The contents of liver CYP, Cytb5 and GST in serum were increased significantly (P < 0.01) and the contents of MDA was reduced significantly (P < 0.01).
  
  
  CONCLUSIONS
  The volatile oil from nutmeg showed induction effect on the hepatic microsomal CYP in mice.
authors.affiliation: Dept of Pharmacology, Shenyang Medical College, Shenyang 110034, China. zhaorunying@sohu.com
authors.forename: Runying
authors.initials: R
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Lini
authors.initials: L
authors.lastname: Zhao
authors.forename: Zhao
authors.initials: Z
authors.lastname: Li
authors.forename: Junping
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D026323:Myristica / Q000737:chemistry*; D009822:Oils, Volatile / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D010938:Plant Oils; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System