title: [Proliferative cutaneous epithelioid angiomatous nodule].
abstract: The cutaneous epithelioid angiomatous nodule is an uncommon benign vascular proliferation that has only recently been described. Clinically, it usually presents as a solitary, fast-growing, small reddish papulous or nodular lesion on the trunk or limbs of adults. Histopathologic study reveals a proliferation of epithelioid cells and predominantly solid, well delimited, unilobular growth in the superficial dermis. Well defined vessels are often found permeating the lesion, which also shows a certain degree of inflammatory infiltration. The cells contain abundant pink cytoplasm, often with vacuoles, and vesicular nuclei with prominent nucleoli. The morphology of these cells is relatively uniform, without atypia or pleomorphism, although mitoses are not uncommon. We report 2 new cases of cutaneous epithelioid angiomatous nodules, the first in a 28-year-old pregnant woman and the second in a 27-year-old man. In both cases, the usual characteristics of this entity were present, but with the peculiarity of a high mitotic index. We discuss the differential diagnosis of cutaneous epithelioid angiomatous nodules with other vascular proliferations that exhibit epithelioid cytology.
authors.affiliation: Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España. celiareq@hotmail.com
authors.forename: Celia
authors.initials: C
authors.lastname: Requena Caballero
authors.forename: M J
authors.initials: MJ
authors.lastname: Nicolau
authors.forename: R
authors.initials: R
authors.lastname: Haro
authors.forename: A
authors.initials: A
authors.lastname: Martorell
authors.forename: O
authors.initials: O
authors.lastname: Sanmartín
authors.forename: B
authors.initials: B
authors.lastname: Llombart
authors.forename: R
authors.initials: R
authors.lastname: Botella
authors.forename: C
authors.initials: C
authors.lastname: Guillén
authors.forename: L
authors.initials: L
authors.lastname: Requena
mesh_terms: D000328:Adult; D016917:Angiomatosis, Bacillary / Q000175:diagnosis; D003937:Diagnosis, Differential; D005153:Facial Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis; D006391:Hemangioma / Q000175:diagnosis / Q000473:pathology*; D006394:Hemangiosarcoma / Q000175:diagnosis; D006801:Humans; D008297:Male; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000473:pathology*; D012782:Shoulder; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*