Exercise, PGC-1alpha, and metabolic adaptation in skeletal muscle.
Endurance exercise promotes skeletal muscle adaptation, and exercise-induced peroxisome proliferator-activated receptor gamma coactivator-1alpha (Pgc-1alpha) gene expression may play a pivotal role in the adaptive processes. Recent applications of mouse genetic models and in vivo imaging in exercise studies have started to delineate the signaling-transcription pathways that are involved in the regulation of the Pgc-1alpha gene. These studies revealed the importance of p38 mitogen-activated protein kinase/activating transcription factor 2 and protein kinase D/histone deacetylase 5 signaling transcription axes in exercise-induced Pgc-1alpha transcription and metabolic adaptation in skeletal muscle. The signaling-transcription network that is responsible for exercise-induced skeletal muscle adaption remains to be fully elucidated.
Yan
Zhen
Z
Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. zhen.yan@virginia.edu
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D005786:Gene Expression Regulation; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010805:Physical Conditioning, Animal / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors
D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors