Is kidney ischemia the central mechanism in parallel activation of the renin and sympathetic system?
In chronic kidney disease simultaneous activation of the renin-angiotensin and sympathetic systems occurs. Kidney ischemia seems to play a key role in the pathogenesis. This review firstly summarizes experimental and clinical evidence in chronic kidney disease supporting this idea and addresses the possibility that this mechanism is also relevant in some other disease conditions.
Siddiqi
Laima
L
Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands.
Joles
Jaap A
JA
Grassi
Guido
G
Blankestijn
Peter J
PJ
D000450:Aldosterone / Q000502:physiology; D000809:Angiotensins / Q000502:physiology; D001794:Blood Pressure; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D024821:Metabolic Syndrome / Q000503:physiopathology; D012083:Renin / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D000809:Angiotensins; D000450:Aldosterone; D012083:Renin