Does subtle progesterone rise on the day of HCG affect pregnancy rate in long agonist ICSI cycles?
OBJECTIVE
To evaluate the impact of subtle progesterone (P4) rise on the day of HCG on pregnancy outcome in ICSI patients stimulated with long agonist protocol.


METHODS
One hundred forty-nine consecutive controlled ovarian hyperstimulation cycles for ICSI using long luteal agonist protocol.


RESULTS
Mean serum progesterone on day of hCG was 0.88+/-0.51 ng/mL values > or =1 ng/mL were found in 34.2% of cycles. Serum E2 on day of hCG and number of oocytes retrieved were significantly higher in the group with P4 > or = 1 ng/mL. The area under ROC for serum progesterone in prediction of pregnancy was 0.52, indicating that within the values studied, serum progesterone on day of hCG is not predictive of pregnancy outcome.


CONCLUSIONS
P4 values > or =1 ng/mL on day of hCG are common in long agonist ICSI cycles particularly with high response. Within the P4 values encountered in this study, implantation and pregnancy rates are not adversely affected.
Saleh
Hisham Ali
HA
Department of Obstetrics and Gynecology, Alexandria University, Alexandria, Egypt.
Omran
Mervat Sheikh El-Arab
MS
Draz
Mohamed
M
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood*; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008183:Luteal Phase; D008297:Male; D006080:Ovarian Follicle / Q000473:pathology; D010053:Ovary / Q000473:pathology; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood*; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*
D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone