Vasoplegic syndrome during liver transplantation.
A 56-yr-old woman with chronic hepatitis B and decompensated hepatic cirrhosis was treated with liver transplantation. At the beginning of the neohepatic phase, her arterial blood pressure remained at 60/40 mm Hg for approximately 40 min and did not respond to vasoconstrictive drugs. Her other clinical and laboratory values remained normal, apart from a high cardiac output and low systemic vascular resistance. This patient was diagnosed with vasoplegic syndrome and was treated with i.v. infusion of methylene blue (0.5 mg/kg) and norepinephrine. This report has potential significance to treatment in patients who undergo orthotopic liver transplantation.
Cao
Zhongping
Z
Department of Anesthesia, The Southwest Hospital of The Third Military Medical University, Chongqing, 400038, China.
Gao
Yuqi
Y
Tao
Guocai
G
D000328:Adult; D000931:Antidotes / Q000627:therapeutic use; D001784:Blood Gas Analysis; D016534:Cardiac Output, High / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006509:Hepatitis B / Q000601:surgery; D006801:Humans; D007022:Hypotension / Q000188:drug therapy / Q000503:physiopathology*; D007431:Intraoperative Complications / Q000188:drug therapy / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000601:surgery; D016031:Liver Transplantation / Q000502:physiology*; D008751:Methylene Blue / Q000627:therapeutic use; D009638:Norepinephrine / Q000627:therapeutic use; D010656:Phenylephrine / Q000627:therapeutic use; D013577:Syndrome; D013610:Tachycardia / Q000188:drug therapy / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
D000931:Antidotes; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D008751:Methylene Blue; D009638:Norepinephrine