title: Positive association of the pericentrin (PCNT) gene with major depressive disorder in the Japanese population.
abstract: BACKGROUND
  Pericentrin (PCNT) interacts with disruption-in-schizophrenia 1 (DISC1), a known genetic risk factor for schizophrenia, bipolar disorder and major depressive disorder (MDD). We sought to determine whether the PCNT gene is implicated in MDD.
  
  
  METHODS
  We performed case-control association analyses in the Japanese population. We analyzed 9 single nucleotide polymorphisms (SNPs) in 173 patients with MDD and 348 healthy controls.
  
  
  RESULTS
  We found a significant allelic association between 3 SNPs (rs3788265, rs2073376 and rs2073380) of the PCNT gene and MDD (p = 0.006, 0.005 and 0.021, respectively). After correction for multiple testing, 2 SNPs (rs3788265 and rs2073376) retained significant allelic associations with MDD. In addition, we found a significant association between the 2 marker haplotypes (r3788265 and rs2073376) and MDD (permutation p = 0.011).
  
  
  CONCLUSIONS
  Our sample was small and comprised only Japanese participants. In addition, owing to the late onset of MDD, it is possible that the disorder will develop in at least some participants in our control group. Finally, we did not show how SNPs of the PCNT gene alter its function.
  
  
  CONCLUSIONS
  Our results suggest that genetic variations in the PCNT gene may play a significant role in the etiology of MDD in the Japanese population.
authors.affiliation: Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-8-15 Kuramoto-cho, Tokushima 770-8503, Japan. shu-numata@umin.ac.jp
authors.forename: Shusuke
authors.initials: S
authors.lastname: Numata
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Iga
authors.forename: Masahito
authors.initials: M
authors.lastname: Nakataki
authors.forename: Shin'ya
authors.initials: S
authors.lastname: Tayoshi
authors.forename: Toshihito
authors.initials: T
authors.lastname: Tanahashi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Itakura
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Ueno
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohmori
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens / Q000235:genetics*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D012984:Software; D055815:Young Adult
chemical_list: D000941:Antigens; C086178:pericentrin