title: Four familial cases of epidermodysplasia verruciformis: mother and three sons.
abstract: Epidermodysplasia verruciformis (EV) is a rare genodermatosis associated with a high risk of skin cancer. In this report, we present three Iranian brothers and their mother with extensive seborrheic keratosis-like (SK-like) viral warts. Initial facial lesions developed in the first decade and disseminated with time. The patients showed SK-like viral warts characterized by dark brown or black pigmented proliferative lesions with hyperkeratotic surfaces. The histopathological findings were consistent with the diagnosis of EV. There are few reports of familial epidermodysplasia verruciformis especially in a mother and her three sons.
authors.affiliation: Skin Research Center, Shahid Beheshti University, M.C. Shohada-e Tajrish Hospital, Tehran, Iran. rmrobati@gmail.com
authors.forename: Reza Mahmoud
authors.initials: RM
authors.lastname: Robati
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Marefat
authors.forename: Marjan
authors.initials: M
authors.lastname: Saeedi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rahmati-Roodsari
authors.forename: Zahra
authors.initials: Z
authors.lastname: Asadi-Kani
mesh_terms: D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D002648:Child; D003937:Diagnosis, Differential; D004198:Disease Susceptibility; D004819:Epidermodysplasia Verruciformis / Q000175:diagnosis / Q000235:genetics*; D005148:Facial Dermatoses / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006229:Hand Dermatoses / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D014010:Tinea Versicolor / Q000175:diagnosis