title: Usefulness of current risk groups in the treatment of surgically staged endometrial carcinomas; a population-based study from Western Sweden.
abstract: BACKGROUND
  Endometrial carcinoma is the most common malignancy of the female genital tract and its incidence is increasing. However, treatment results have not improved during the last decades.
  
  
  METHODS
  Our regional quality register was used to evaluate treatment results for the period between January 1995 and December 2003. This study includes 2211 consecutive patients, of which 1993 surgically staged patients were evaluated in detail. Of these, 831 (53%) were at low risk and were given no further treatment after primary surgery. Patients with moderate- and high-risk tumors were postoperatively treated according to the respective protocols of one Swedish and one international study. Postoperative vaginal brachytherapy +/- external radiation was given to 486 (31%) patients at moderate risk, while 234 (15%) had high-risk disease and were randomized to external radiation + brachytherapy or external radiation + brachyterapy + chemotherapy.
  
  
  RESULTS
  Overall cause-specific 5- and 10-year survival was 83.9% and 81.3%, respectively, for all included patients. The corresponding figures for surgically staged patients were 87.4% and 84.9%, respectively. One important observation was that there was no significant difference in survival between patients at low and moderate risk.
  
  
  CONCLUSIONS
  The results strongly suggest that the risk groups used during this study period were not optimal. It is recommended to use smaller, better specified groups defined by more prognostic factors for enhanced individualization of treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Skövde City Hospital, Sweden.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Paulsson
authors.forename: Anna
authors.initials: A
authors.lastname: Genell
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Jakobsen
authors.forename: György
authors.initials: G
authors.lastname: Horvath
mesh_terms: D000368:Aged; D002423:Cause of Death; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology