title: [Distribution of specific IgG subclasses in patients with pertussis and in healthy persons].
abstract: OBJECTIVE
  To assess level of IgG1, IgG2, IgG3, and IgG4 to complex of antigens of Bordetella pertussis in patients with whooping cough and healthy children and adults.
  
  
  METHODS
  Levels of anti-pertussis IgG subclasses in sera of patients with pertussis and healthy children and adults were measured with solid phase immunoenzyme assay using peroxidase-conjugated monoclonal antibodies to human IgG1, IgG2, IgG3, and IgG4.
  
  
  RESULTS
  In patients with pertussis, IgG1-IgG3-IgG2-IgG4 type of distribution of subclasses with predominance of IgG1 and IgG3 was revealed. In healthy children and adults the character type of subclasses distribution was IgG1-IgG2-IgG4 with absent or low level of IgG3.
  
  
  CONCLUSIONS
  Detection of specific IgG3 mainly in patients with pertussis allows to consider them as a reliable serological sign of pertussis infection.
authors.forename: E M
authors.initials: EM
authors.lastname: Zaĭtsev
authors.forename: I K
authors.initials: IK
authors.lastname: Mazurova
authors.forename: M S
authors.initials: MS
authors.lastname: Petrova
authors.forename: L I
authors.initials: LI
authors.lastname: Krasnoproshina
authors.forename: T I
authors.initials: TI
authors.lastname: Astakhova
authors.forename: N S
authors.initials: NS
authors.lastname: Zakharova
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D000918:Antibody Specificity; D015415:Biomarkers / Q000097:blood; D001886:Bordetella pertussis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000145:classification / Q000276:immunology; D007223:Infant; D008875:Middle Aged; D014917:Whooping Cough / Q000097:blood / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D007074:Immunoglobulin G