title: Thyroid status can influence brain mast cell population.
abstract: Neuroanatomical mapping as well as the influence of thyroid status on brain mast cell distribution and detectable mast cell number in adult Rana esculenta is studied. Treatment with tizoxin (T4) does not modify number or activational state of brain mast cells, whereas administration of the antithyroid agent 6-n-propyl-2-thiouracil induces a significant increase (up to 40%) in the mast cell number within the telencephalon and diencephalon. Hypophysectomy induces a significant decrease (up to 65%) of mast cells in all brain regions, whereas the pituitary homogenate augments their number. The results suggest that the pituitary-thyroid axis may be involved in the regulation of brain mast cell population.
authors.affiliation: Department of Life Sciences, Second University of Naples, Naples, Italy.
authors.forename: Gabriella Chieffi
authors.initials: GC
authors.lastname: Baccari
authors.forename: Rossella
authors.initials: R
authors.lastname: Monteforte
authors.forename: Claudia
authors.initials: C
authors.lastname: Pinelli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Santillo
authors.forename: Gianluca
authors.initials: G
authors.lastname: Polese
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Rastogi
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology* / Q000378:metabolism*; D002452:Cell Count; D008407:Mast Cells / Q000166:cytology* / Q000378:metabolism*; D011893:Rana esculenta / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism*