title: Carotid plaque analysis: comparison of dual-source computed tomography (CT) findings and histopathological correlation.
abstract: OBJECTIVE
  Plaque morphology is an important predictor of stroke risk and may also be a predictor of postoperative outcome after carotid endarterectomy (CEA). Thus, the purpose of our study was to evaluate the findings of preoperative dual-source computed tomography (DSCT) of carotid plaque morphology and correlate these findings with histopathological findings.
  
  
  METHODS
  Thirty patients undergoing CEA due to neurological events and high-grade carotid artery stenosis were evaluated with DSCT for degree of stenosis following the North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria and for non-invasive plaque morphology prior to CEA. CT protocol was as follows (SOMATOM Definition, Siemens Medical Solutions, Forchheim, Germany): A dual-energy protocol was used with tube A (140 kV, 55 mA) and tube B (80 kV, 230 mA) with 2 x 64 x 0.6-mm collimation, pitch 0.65 and rotation time of 0.33 s. Histopathological work-up was performed on the surgically retrieved tissues. The findings from DSCT and histopathology were compared with respect to image quality and plaque composition (fatty plaque, mixed plaque and calcified plaque), were correlated with histological specimens and classified according to the American Heart Association (AHA) classification of atherosclerotic plaque. Pearson correlation and kappa statistics were performed.
  
  
  RESULTS
  The image quality of DSCT was rated as 'excellent' in all the examinations. The mean degree of stenosis was quantified as 82%. The sensitivity of DSCT for the detection of calcification was 100% (standard deviation (SD) 0%, confidence interval (CI): 99-100). While the sensitivity for the detection of mixed plaques was 89% (SD 12%, CI: 79-98), it was 85% (SD 10%, CI: 76-92) for the detection of low-density fatty plaques. The mean degree of agreement was k=0.81.
  
  
  CONCLUSIONS
  DSCT angiography of the carotid arteries is feasible and the evaluation of carotid plaque composition allows non-invasive assessment of different plaque components. This may have an impact on the non-invasive differentiation of vulnerable plaques.
authors.affiliation: Department of Diagnostic Radiology, RWTH Aachen University, Aachen, NRW, Germany. das@rad.rwth-aachen.de
authors.forename: M
authors.initials: M
authors.lastname: Das
authors.forename: T
authors.initials: T
authors.lastname: Braunschweig
authors.forename: G
authors.initials: G
authors.lastname: Mühlenbruch
authors.forename: A H
authors.initials: AH
authors.lastname: Mahnken
authors.forename: T
authors.initials: T
authors.lastname: Krings
authors.forename: S
authors.initials: S
authors.lastname: Langer
authors.forename: T
authors.initials: T
authors.lastname: Koeppel
authors.forename: M
authors.initials: M
authors.lastname: Jacobs
authors.forename: R W
authors.initials: RW
authors.lastname: Günther
authors.forename: G
authors.initials: G
authors.lastname: Mommertz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography / Q000379:methods*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016612:Paraffin Embedding; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*