title: Cutaneous squamous cell carcinoma in Calabar, southern Nigeria.
abstract: BACKGROUND
  Several studies have shown that in Africa squamous cell carcinoma (SCC) is commoner than other skin malignancies. The risk factors are grouped generally into solar and nonsolar factors and their contributions vary with race, geographical region and site of lesion. This study attempted to identify risk factors and outcome of management of this problem in our region of southern Nigeria.
  
  
  METHODS
  All patients with histological diagnosis of SCC presenting to the University of Calabar Teaching Hospital during the period January 2005 to December 2006 were evaluated.
  
  
  RESULTS
  In total, 10 patients (6 male, 4 female, mean age 39.3 years, range 16-62) were seen. There were six patients (60%) with Marjolin's ulcer (MU) of the leg, with a male:female ratio of 5:1 and a latency period of 14.7 years, with trauma as the leading cause of injury. The other four patients (40%) had non-MU SCC. Two of these four patients (one man, one woman) were albino, and had lesions that involved the head. The other two patients were both women, and had vulval lesions. All 10 patients had delayed hospital admission, after poor results with topical herbal treatment. After hospital treatment, the results were satisfactory in three patients (two with MU and the male albino patient). The other seven patients had generally poor results from treatment, which comprised various combinations of excision, adjuvant chemotherapy and radiation.
  
  
  CONCLUSIONS
  Ignorance and sociocultural factors were underlying issues in delaying treatment. Education highlighting the risk associated with chronic wounds and albinism, and the need for prevention, prompt treatment and proper surgical management, would improve prognosis with a reduction in the healthcare cost of this problem.
authors.affiliation: Department of Surgery, University of Calabar Teaching Hospital, Calabar, Nigeria. mauefas@yahoo.com
authors.forename: M E
authors.initials: ME
authors.lastname: Asuquo
authors.forename: A M
authors.initials: AM
authors.lastname: Udosen
authors.forename: I A
authors.initials: IA
authors.lastname: Ikpeme
authors.forename: N E
authors.initials: NE
authors.lastname: Ngim
authors.forename: O O
authors.initials: OO
authors.lastname: Otei
authors.forename: G
authors.initials: G
authors.lastname: Ebughe
authors.forename: E E
authors.initials: EE
authors.lastname: Bassey
mesh_terms: D000293:Adolescent; D000328:Adult; D000417:Albinism / Q000150:complications; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D012880:Skin Pigmentation; D055815:Young Adult