Total synthesis of (-)-agelastatin A: the application of a sequential sigmatropic rearrangement.
An enantioselective total synthesis of (-)-agelastatin A from (-)-2,3-O-isopropylidene-d-threitol is described. The sequential Overman/Mislow-Evans rearrangement of the allylic bistrichloroimidate is the key step, which efficiently installed a diaminohydroxy group.
Hama
Naoto
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Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Matsuda
Tomoki
T
Sato
Takaaki
T
Chida
Noritaka
N