Aphthous ulcers (recurrent).
BACKGROUND
Most people with recurrent aphthous ulcers develop a few ulcers less than 1 cm in diameter, that heal after 5-14 days without scarring. The causes are unknown, but risks of recurrence may decrease if the person gives up smoking. Local physical trauma may trigger ulcers in susceptible people. In 10% of sufferers, lesions are more than 1 cm in diameter, and can cause scarring.


METHODS
We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for recurrent aphthous ulcers? We searched: Medline, Embase, The Cochrane Library and other important databases up to August 2006 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).


RESULTS
We found 18 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.


CONCLUSIONS
In this systematic review we present information relating to the effectiveness and safety of the following interventions: analgesics (local), carbenoxolone mouthwash, chlorhexidine (and similar agents), corticosteroids (topical), and tetracycline antibiotic mouthwash.
Porter
Stephen R
SR
Eastman Dental Institute for Oral Health Care Sciences UCL, University of London, London, UK.
Scully Cbe
Crispian
C
D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002229:Carbenoxolone / Q000627:therapeutic use; D002710:Chlorhexidine / Q000627:therapeutic use; D006801:Humans; D009067:Mouthwashes / Q000627:therapeutic use; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000188:drug therapy; D014456:Ulcer
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009067:Mouthwashes; D002229:Carbenoxolone; D002710:Chlorhexidine