[Metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces].
OBJECTIVE
To study the metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces.


METHODS
The urine and feces of rats were collected at different times after orally administration of total flavonoids from Semen Ziziphi Spinosae, disposed by HP-20 macroporous resin, and then detected by both HPLC and LC-MSn methods.


RESULTS
Two main proto-drugs, spinosin and 6'"-feruloylspinosin, along with a metabolite, swertish (M1), are detected in both urine and feces of rat.


CONCLUSIONS
Flavonoids of Semen Ziziphi Spinosae are excreted in urine and feces mainly in form of proto-drug, while little in form of metabolites, such as swertish.
Zhang
Lei
L
Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Centre, Beijing 100191, China.
Xiang
Cheng
C
Wang
Bin
B
Zhao
Yuying
Y
Zhang
Qingying
Q
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry; D005419:Flavonoids / Q000032:analysis*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012661:Semen / Q000737:chemistry; D014556:Urine / Q000737:chemistry*
D005419:Flavonoids; C055669:spinosin