title: Could the MMR vaccine replace the measles vaccine at one year of age in Egypt?
abstract: This cross-sectional study evaluated the immune status of non-vaccinated healthy infants to determine if it is possible to replace both measles vaccine (at 9 months) and measles, mumps and rubella (MMR) vaccine (at 18 months) with a single dose of MMR at 12 months. Serum samples from 566 children in Alexandria, Egypt showed a significant decrease in the seropositive rate to the 3 viral diseases with increasing age, but a significant increase in the seropositive rate among infants who were ranked 1st or 2nd in their family, full-term or born to mothers with no history of hypertension during pregnancy. We recommend administration of the first dose of MMR vaccine between 9 and 12 months of age, and a booster dose of MMR vaccine at 4 years of age.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: Abbassy
authors.forename: S S
authors.initials: SS
authors.lastname: Barakat
authors.forename: M M
authors.initials: MM
authors.lastname: Abd El Fattah
authors.forename: Z N
authors.initials: ZN
authors.lastname: Said
authors.forename: H A
authors.initials: HA
authors.lastname: El Metwally
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006287:Health Planning Guidelines; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008457:Measles / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000276:immunology; D009107:Mumps / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D020380:Needs Assessment / Q000458:organization & administration*; D012409:Rubella / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D016036:Seroepidemiologic Studies; D014611:Vaccination / Q000379:methods*
chemical_list: D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine