Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT.
We aimed at securing sufficient concentrations of (10)B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron component liposome. It consisted of three different kinds of amino acid derivatives and two fatty acids, and could react directly with the peptide synthesized first on resin by Fmoc solid-phase synthesis. In this study, lipid analog conjugated with HIV-TAT peptide (domain of human immunodeficiency virus TAT protein) and boronophenylalanine (BPA) was synthesized and successfully incorporated into liposomes.
Shirakawa
Makoto
M
Department of Graduate School of Comprehensive Human Sciences, Faculty of Functional and Regulatory Medical Sciences, University of Tsukuba, Japan. m0720347@md.tsukuba.ac.jp
Yamamto
Tetsuya
T
Nakai
Kei
K
Aburai
Kenichi
K
Kawatobi
Sho
S
Tsurubuchi
Takao
T
Yamamoto
Yohei
Y
Yokoyama
Yuusaku
Y
Okuno
Hiroaki
H
Matsumura
Akira
A
D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D016503:Drug Delivery Systems; D006801:Humans; D007554:Isotopes / Q000737:chemistry / Q000627:therapeutic use; D055666:Lipopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D008081:Liposomes / Q000737:chemistry*; D008564:Membrane Potentials; D009369:Neoplasms / Q000532:radiotherapy; D010316:Particle Size; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
D001896:Boron Compounds; D007554:Isotopes; D055666:Lipopeptides; D008081:Liposomes; D011838:Radiation-Sensitizing Agents; D054322:tat Gene Products, Human Immunodeficiency Virus; D010649:Phenylalanine; C033685:4-boronophenylalanine