title: Long-term effect of chronic oral anticoagulation: focus on coronary artery disease.
abstract: Coronary artery disease remains one of the most important causes of morbidity and mortality worldwide, with a disease burden that does not seem to have decreased significantly over time. Since their developments, oral drugs that are able to reduce the coagulation properties of blood (i.e., oral anticoagulants such as warfarin or dicoumarol) have been tested in thousands of patients with, or suspected with, coronary artery disease, however they have yielded disparate and conflicting results. The advent of oral antiplatelet agents has further put into a niche the apparent role of oral anticoagulant therapy in subjects with established coronary artery disease (i.e., in the setting of secondary prevention). However, the current and future role of oral anticoagulants in the secondary prevention of coronary artery disease remains very important, as testified to by the ongoing research by several major companies and investigators focusing on the development of novel oral anticoagulants. This review provides a succinct and updated appraisal of the long-term effects of chronic oral anticoagulation in the setting of coronary artery disease.
authors.affiliation: Institute of Cardiology, Catholic University, Rome, Italy. mlotrionte@gmail.com
authors.forename: Marzia
authors.initials: M
authors.lastname: Lotrionte
authors.forename: Davide
authors.initials: D
authors.lastname: Castagno
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Agostoni
authors.forename: Antonio
authors.initials: A
authors.lastname: Abbate
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sangiorgi
authors.forename: Imad
authors.initials: I
authors.lastname: Sheiban
authors.forename: Giuseppe G L
authors.initials: GG
authors.lastname: Biondi-Zoccai
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy; D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D018570:Risk Assessment; D055502:Secondary Prevention; D013997:Time Factors; D014481:United States
chemical_list: D000925:Anticoagulants