HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS).
OBJECTIVE
To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS.


METHODS
Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 90th percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample.


RESULTS
In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p < 0.001). The cut-off values for IR were: HOMA1-IR > 2.7 and HOMA2-IR > 1.8; and, for MS were: HOMA1-IR > 2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR > 1.4 (sensitivity: 79.2%; specificity: 61.2%).


CONCLUSIONS
The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations.
Geloneze
Bruno
B
Laboratório de Investigação em Metabolismo e Diabetes, Instituto Nacional de Ciência e Tecnologia, Rua Carlos Chagas 420, Campinas, SP, Brazil. bgeloneze@terra.com.br
Vasques
Ana Carolina Junqueira
AC
Stabe
Christiane França Camargo
CF
Pareja
José Carlos
JC
Rosado
Lina Enriqueta Frandsen Paez de Lima
LE
Queiroz
Elaine Cristina de
EC
Tambascia
Marcos Antonio
MA
D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D012372:ROC Curve; D012016:Reference Values; D055815:Young Adult