title: Bone mineral density in patients with familial Mediterranean fever.
abstract: This study was carried out to determine lumbar and femoral bone mineral density (BMD) in patients with familial Mediterranean fever (FMF), an autosomal-recessive disease characterized by recurrent episodes of peritonitis, pleuritis, and arthritis, which are usually associated with fever. In patients with FMF and control subjects, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured. BMD was determined at the lumbar spine (L1-4) and the femoral regions (neck and total) using dual energy X-ray absorptiometry. Twenty-eight FMF patients and 30 control subjects without a history of inflammatory disease participated in our study. The demographic variables, such as age, sex and body mass index were similar between patients and controls (P > 0.05). We found statistically significant difference in ESR and CRP between FMF patients and controls (P < 0.01, P < 0.05 respectively). There was statistically significant difference in lumbar spine, femoral neck, and total femur BMD between FMF patients and control groups (P < 0.001, P < 0.01, P < 0.01 respectively).Our study indicates that lumbar spine and femoral neck and total femur BMD in patients with FMF may be lower than in healthy subjects.
authors.affiliation: Department of Physical Medicine, Medical Faculty, Ataturk University, Erzurum, Turkey. kadiryildirim88@hotmail.com
authors.forename: Kadir
authors.initials: K
authors.lastname: Yildirim
authors.forename: Saliha
authors.initials: S
authors.lastname: Karatay
authors.forename: Ramazan
authors.initials: R
authors.lastname: Cetinkaya
authors.forename: Hulya
authors.initials: H
authors.lastname: Uzkeser
authors.forename: Akin
authors.initials: A
authors.lastname: Erdal
authors.forename: Ilyas
authors.initials: I
authors.lastname: Capoglu
authors.forename: Fazile Hatipoglu
authors.initials: FH
authors.lastname: Erdem
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015415:Biomarkers; D001799:Blood Sedimentation; D015519:Bone Density / Q000235:genetics*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism; D018450:Disease Progression; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D011237:Predictive Value of Tests; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein