title: Pathological classification of DCIS and planning of therapeutic management.
abstract: BACKGROUND
  Ductal intraepitelial neoplasia (DIN) represents a spectrum of disease that may progress from usual hyperplasia to ductal carcinoma in situ (DCIS) grade 3. The aim of the study was to asses the correlation between the DIN classification and the surgical treatment including sentinel lymph node biopsy (SLNB).
  
  
  METHODS
  In this retrospective study, 229 patients with DIN had undergone conservative or radical surgical treatment and SLNB in cases of DIN1C-DIN3.
  
  
  RESULTS
  Breast conservative surgery was the definitive treatment in 80% of the cases. The H&E evaluation of excised sentinel nodes was negative for metastatic disease; nevertheless the immunohistochemical (IHC) evaluation revealed the presence of metastatic cells in 6 patients (3.7%).
  
  
  CONCLUSIONS
  In cases of DIN lesions SLNB is not indicated. The only reason SLNB should be considered is when there is an evidence of invasive foci at definitive histology or when radical mastectomy is proposed.
authors.affiliation: Department of Surgery, Tor Vergata University, Rome, Italy. o.buonomo@inwind.it
authors.forename: O
authors.initials: O
authors.lastname: Buonomo
authors.forename: P
authors.initials: P
authors.lastname: Orsaria
authors.forename: G
authors.initials: G
authors.lastname: Contino
authors.forename: D
authors.initials: D
authors.lastname: Varvaras
authors.forename: A
authors.initials: A
authors.lastname: Gioia
authors.forename: E
authors.initials: E
authors.lastname: Bonanno
authors.forename: C
authors.initials: C
authors.lastname: Pistolese
authors.forename: E
authors.initials: E
authors.lastname: Cossu
authors.forename: T
authors.initials: T
authors.lastname: Perretta
authors.forename: O
authors.initials: O
authors.lastname: Schillaci
authors.forename: G
authors.initials: G
authors.lastname: Del Monte
authors.forename: M
authors.initials: M
authors.lastname: Roselli
authors.forename: T C
authors.initials: TC
authors.lastname: Mineo
authors.forename: G
authors.initials: G
authors.lastname: Petrella
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000145:classification* / Q000473:pathology / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000145:classification* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010347:Patient Care Planning; D021701:Sentinel Lymph Node Biopsy