title: Neurosteroid production in the songbird brain: a re-evaluation of core principles.
abstract: Concepts of brain-steroid signaling have traditionally placed emphasis on the gonads and adrenals as the source of steroids, the strict dichotomy of early developmental ("organizational") and mature ("activational") effects, and a relatively slow mechanism of signaling through intranuclear receptors. Continuing research shows that these concepts are not inaccurate, but they are certainly incomplete. In this review, we focus on the song control circuit of songbird species to demonstrate how each of these concepts is limited. We discuss the solid evidence for steroid synthesis within the brain ("neurosteroidogenesis"), the role of neurosteroids in organizational events that occur both early in development and later in life, and how neurosteroids can act in acute and non-traditional ways. The songbird model therefore illustrates how neurosteroids can dramatically increase the diversity of steroid-sensitive brain functions in a behaviorally-relevant system. We hope this inspires further research and thought into neurosteroid signaling in songbirds and other animals.
authors.affiliation: Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: London
authors.forename: Luke
authors.initials: L
authors.lastname: Remage-Healey
authors.forename: Barney A
authors.initials: BA
authors.lastname: Schlinger
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D008954:Models, Biological; D018377:Neurotransmitter Agents / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology; D017729:Presynaptic Terminals / Q000378:metabolism; D020308:Songbirds / Q000196:embryology / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D013256:Steroids / Q000096:biosynthesis* / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents; D013256:Steroids