Antibacterial properties of soap containing some fatty acid esters.
Synopsis Chemical microbial inhibitors compatible with formulations of soaps and deodorant perfumes are more effective if they are substantive to the skin. However, highly effective inhibitors are toxic and their substantivity on skin may accentuate the toxicity. Natural compounds such as short to medium chain fatty acids and their derivatives, which are known to be germicidal, offer a viable alternative to chemical inhibitors. We report here the synthesis of sodium 2-lauroyloxy propionate and an in vivo method to test its substantivity on skin following its incorporation in soaps. Among several compounds tested, sodium 2-lauroyloxy propionate was found to be highly substantive in soap formulation.
Pandey
N K
NK
Hindustan Lever Research Centre, Andheri (East), Bombay 400 099, India.
Natraj
C V
CV
Kalle
G P
GP
Nambudiry
M E
ME