title: Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans.
abstract: Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).
authors.affiliation: WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Garten
authors.forename: C Todd
authors.initials: CT
authors.lastname: Davis
authors.forename: Colin A
authors.initials: CA
authors.lastname: Russell
authors.forename: Bo
authors.initials: B
authors.lastname: Shu
authors.forename: Stephen
authors.initials: S
authors.lastname: Lindstrom
authors.forename: Amanda
authors.initials: A
authors.lastname: Balish
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Sessions
authors.forename: Xiyan
authors.initials: X
authors.lastname: Xu
authors.forename: Eugene
authors.initials: E
authors.lastname: Skepner
authors.forename: Varough
authors.initials: V
authors.lastname: Deyde
authors.forename: Margaret
authors.initials: M
authors.lastname: Okomo-Adhiambo
authors.forename: Larisa
authors.initials: L
authors.lastname: Gubareva
authors.forename: John
authors.initials: J
authors.lastname: Barnes
authors.forename: Catherine B
authors.initials: CB
authors.lastname: Smith
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Emery
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Hillman
authors.forename: Pierre
authors.initials: P
authors.lastname: Rivailler
authors.forename: James
authors.initials: J
authors.lastname: Smagala
authors.forename: Miranda
authors.initials: M
authors.lastname: de Graaf
authors.forename: David F
authors.initials: DF
authors.lastname: Burke
authors.forename: Ron A M
authors.initials: RA
authors.lastname: Fouchier
authors.forename: Claudia
authors.initials: C
authors.lastname: Pappas
authors.forename: Celia M
authors.initials: CM
authors.lastname: Alpuche-Aranda
authors.forename: Hugo
authors.initials: H
authors.lastname: López-Gatell
authors.forename: Hiram
authors.initials: H
authors.lastname: Olivera
authors.forename: Irma
authors.initials: I
authors.lastname: López
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Myers
authors.forename: Dennis
authors.initials: D
authors.lastname: Faix
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Blair
authors.forename: Cindy
authors.initials: C
authors.lastname: Yu
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Keene
authors.forename: P David
authors.initials: PD
authors.lastname: Dotson
authors.forename: David
authors.initials: D
authors.lastname: Boxrud
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Sambol
authors.forename: Syed H
authors.initials: SH
authors.lastname: Abid
authors.forename: Kirsten
authors.initials: K
authors.lastname: St George
authors.forename: Tammy
authors.initials: T
authors.lastname: Bannerman
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Moore
authors.forename: David J
authors.initials: DJ
authors.lastname: Stringer
authors.forename: Patricia
authors.initials: P
authors.lastname: Blevins
authors.forename: Gail J
authors.initials: GJ
authors.lastname: Demmler-Harrison
authors.forename: Michele
authors.initials: M
authors.lastname: Ginsberg
authors.forename: Paula
authors.initials: P
authors.lastname: Kriner
authors.forename: Steve
authors.initials: S
authors.lastname: Waterman
authors.forename: Sandra
authors.initials: S
authors.lastname: Smole
authors.forename: Hugo F
authors.initials: HF
authors.lastname: Guevara
authors.forename: Edward A
authors.initials: EA
authors.lastname: Belongia
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Clark
authors.forename: Sara T
authors.initials: ST
authors.lastname: Beatrice
authors.forename: Ruben
authors.initials: R
authors.lastname: Donis
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Katz
authors.forename: Lyn
authors.initials: L
authors.lastname: Finelli
authors.forename: Carolyn B
authors.initials: CB
authors.lastname: Bridges
authors.forename: Michael
authors.initials: M
authors.lastname: Shaw
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Jernigan
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Uyeki
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Smith
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Klimov
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Cox
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D004196:Disease Outbreaks; D019143:Evolution, Molecular; D005814:Genes, Viral; D014644:Genetic Variation; D016679:Genome, Viral; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics; D009980:Influenza A virus / Q000235:genetics; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D009154:Mutation; D009439:Neuraminidase / Q000235:genetics; D009976:Orthomyxoviridae Infections / Q000662:veterinary / Q000821:virology; D010802:Phylogeny; D016865:Reassortant Viruses / Q000235:genetics; D013552:Swine; D013553:Swine Diseases / Q000821:virology; D014763:Viral Matrix Proteins / Q000235:genetics; D017361:Viral Nonstructural Proteins / Q000235:genetics
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; C108309:NS protein, influenza virus; D014763:Viral Matrix Proteins; D017361:Viral Nonstructural Proteins; D009439:Neuraminidase