Keeping the beat in the rising heat.
Circadian clocks use temperature compensation to keep accurate time over a range of temperatures, thus allowing reliable timekeeping under diverse environmental conditions. Mehra et al. (2009) and Baker et al. (2009) now show that phosphorylation-regulated protein degradation plays a key role in circadian temperature compensation.
Virshup
David M
DM
Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore 169857. david.virshup@duke-nus.edu.sg
Forger
Daniel B
DB
D001683:Biological Clocks; D047390:Casein Kinase II / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D002940:Circadian Rhythm; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D009492:Neurospora crassa / Q000201:enzymology / Q000502:physiology*; D010766:Phosphorylation; D013696:Temperature
D005656:Fungal Proteins; D047390:Casein Kinase II