title: Nutritional status of patients with biliary atresia and autoimmune hepatitis related to serum levels of vitamins A, D and E.
abstract: BACKGROUND
  Chronic liver disease may induce to malabsorption of lipids and fat-soluble vitamins, leading to injury of nutritional status.
  
  
  OBJECTIVE
  To evaluate the nutritional status of pediatric-age patients with autoimmune hepatitis and biliary atresia related to serum levels of vitamins A, D and E and the disease severity.
  
  
  METHODS
  This controlled transverse study, evaluated the patients with autoimmune hepatitis and biliary atresia and a reference group paired by sex and age. The patients underwent anthropometric evaluation, alimentary inquiry and determination of serum levels of vitamins A, D and E by high performance liquid chromatography. The Mann-Whitney test, Spearman correlation coefficients and variance analysis (ANOVA) were utilized for data treatment, regarding significant difference if P<0.05.
  
  
  RESULTS
  The highest nutritional deficit was observed in patients with biliary atresia, mainly with cholestasis. The serum levels of vitamins A and E for the reference group changed as a function of age. The serum levels of vitamins A, D and E were higher in reference group than in patients with biliary atresia and autoimmune hepatitis together or separately. There were not difference in the serum levels of vitamins A, D and E between biliary atresia groups with cholestasis and without cholestasis. It was verified correlation between weight/age, triceps skinfold thickness, subscapular skinfold thickness, midarm circumference, midarm fat area values and vitamin A serum levels, as well as between all anthropometric indicators and vitamin E in patients with autoimmune hepatitis and biliary atresia.
  
  
  CONCLUSIONS
  The patients with biliary atresia and cholestasis presented the highest nutritional injury. The patients with biliary atresia and autoimmune hepatitis presented lower serum levels of vitamins A, D and E that in control group. There is a directly proportional correlation between vitamin serum levels, mainly vitamin E, and all anthropometric variables of biliary atresia and autoimmune hepatitis groups.
authors.affiliation: Department of Pediatrics, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Margareth L G
authors.initials: ML
authors.lastname: Saron
authors.forename: Helena T
authors.initials: HT
authors.lastname: Godoy
authors.forename: Gabriel
authors.initials: G
authors.lastname: Hessel
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001656:Biliary Atresia / Q000097:blood* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004812:Epidemiologic Methods; D005260:Female; D019693:Hepatitis, Autoimmune / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009752:Nutritional Status / Q000502:physiology*; D014801:Vitamin A / Q000097:blood*; D014807:Vitamin D / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
chemical_list: D014801:Vitamin A; D014807:Vitamin D; D014810:Vitamin E