Cardiac troponin I and C-reactive protein concentrations in dogs with severe pulmonic stenosis before and after balloon valvuloplasty.
OBJECTIVE
To report cardiac troponin I (cTnI) and C-reactive protein (CRP) concentrations in dogs with severe pulmonic stenosis (PS) before and after balloon valvuloplasty (BV).


BACKGROUND
Increased morbidity and mortality have been reported with severe PS and histopathologic evidence of myocardial damage is demonstrated with BV. Severity of myocardial injury and inflammation associated with severe PS and BV, as assessed by cTnI and CRP, is unknown.


METHODS
Serum cTnI and CRP concentrations were measured in dogs with severe PS (n=23) and following BV (n=16).


RESULTS
Baseline cTnI and CRP were elevated in 7/23 (30.4%) and 8/23 (34.8%) dogs. Median cTnI at baseline and post-BV were 0.20 ng/mL(range, 0.20-1.29 ng/mL) and 2.85 ng/mL (range, 0.21-55.40 ng/mL), respectively. Median CRP at baseline and post-BV were 3.40 microg/mL (range, 0-14.70 microg/mL) and 11.70 microg/mL (range, 4.20-120 microg/mL), respectively. Post-BV concentrations were significantly increased compared to baseline for cTnI (p<0.001) and CRP (p=0.001).


CONCLUSIONS
Serum cTnI and CRP are increased in dogs with severe PS and following BV. Future studies should evaluate whether biomarkers correlate with severity and prognosis of PS or can be used to guide therapy.
Saunders
Ashley B
AB
Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX 77843-4474, USA. asaunders@cvm.tamu.edu
Smith
Brooke E
BE
Fosgate
Geoffery T
GT
Suchodolski
Jan S
JS
Steiner
Jörg M
JM
D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002404:Catheterization / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood* / Q000601:surgery; D004285:Dogs; D005260:Female; D008297:Male; D011666:Pulmonary Valve Stenosis / Q000097:blood / Q000628:therapy / Q000662:veterinary*; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D019210:Troponin I; D002097:C-Reactive Protein