A cysteine-based tripodal chelator with a high affinity and selectivity for copper(I).
A C(3)-symmetric ligand containing three converging cysteine chains anchored on a nitrilotriacetic acid moiety has been synthesized. This tripodal pseudopeptide, which provides three soft sulfur donor groups, exhibits a very high affinity for Cu(I) in either a monometallic complex or the cluster species Cu(6)L(3).
Pujol
Anaïs M
AM
CEA, Inac, Service de Chimie Inorganique et Biologique (UMR_E 3 CEA UJF), F-38054 Grenoble, France.
Gateau
Christelle
C
Lebrun
Colette
C
Delangle
Pascale
P
D002414:Cations, Monovalent / Q000737:chemistry; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D002942:Circular Dichroism; D003300:Copper / Q000737:chemistry*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008958:Models, Molecular; D009571:Nitrilotriacetic Acid / Q000138:chemical synthesis / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013379:Substrate Specificity
D002414:Cations, Monovalent; D002614:Chelating Agents; D008024:Ligands; D003300:Copper; D003545:Cysteine; D009571:Nitrilotriacetic Acid