[Morphological prerequisites of heart ventricles fibrillation in sudden cardiac death].
We studied morphological changes in the myocardium and content of glucose, magnesium, calcium, sodium in pericardial fluid of victims of out of hospital sudden death due to acute coronary insufficiency and prenecrotic stage of myocardial infarction. We established that both in regions of ischemic injury appearing as III degree contracture lesions of cardiomyocytes, zones of intracellular myocytolysis and primary breakdown of myofibrils, as will as in zones of relaxation myocardium loses its contractile properties. This in turn leads to asynchronous contraction of left and right ventricles. As fibrillation develops in both ventricles simultaneously there are all grounds to believe that morphological prerequisite (source of origin) of fibrillation is the presence of areas of ischemic injury and relaxation in the myocardium.
Reznik
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D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D016757:Death, Sudden, Cardiac / Q000473:pathology*; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008859:Microscopy, Polarization; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000473:pathology; D010490:Pericardial Effusion / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D014693:Ventricular Fibrillation / Q000209:etiology / Q000378:metabolism / Q000473:pathology*
D001786:Blood Glucose; D012964:Sodium; D002118:Calcium