title: Isocoumarin glucosides from the scale insect fungus Torrubiella tenuis BCC 12732.
abstract: Three new isocoumarin glucosides (1, 3, and 4), 6,8-dihydroxy-3-methylisocoumarin (2), and 6,8-dihydroxy-3-hydroxymethylisocoumarin (5) were isolated from the scale insect pathogenic fungus Torrubiella tenuis BCC 12732. Structures of these compounds were elucidated using NMR spectroscopic and MS spectrometric analyses. Compound 5 exhibited moderate anti-HSV-1 and antimycobacterial activities with IC(50) and MIC values of 50 and 25 microg/mL, respectively.
authors.affiliation: National Center for Genetic Engineering and Biotechnology, Klong Luang, Pathumthani 12120, Thailand.
authors.forename: Jittra
authors.initials: J
authors.lastname: Kornsakulkarn
authors.forename: Chawanee
authors.initials: C
authors.lastname: Thongpanchang
authors.forename: Sanisa
authors.initials: S
authors.lastname: Lapanun
authors.forename: Kitlada
authors.initials: K
authors.lastname: Srichomthong
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D007313:Insecta / Q000382:microbiology*; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000995:Antitubercular Agents; D000998:Antiviral Agents; D005960:Glucosides; D049934:Isocoumarins