18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preference.
The iboga alkaloid congener, 18-methoxycoronaridine (18-MC), decreases self-administration of multiple drugs of abuse. Here, in a biased procedure, we investigated whether 18-MC would have a similar effect on the acquisition, expression and reinstatement of a cocaine conditioned place preference (CPP) in male Sprague-Dawley rats. While 18-MC attenuated acquisition of a cocaine CPP, it had no effect on CPP expression, and enhanced the reinstatement of cocaine CPP following extinction. Our results are consistent with those obtained using ibogaine, but reinforce the notion that acquisition, expression and reinstatement of a CPP likely involve separate mechanisms.
McCallum
Sarah E
SE
Albany Medical College, Albany, NY, USA. mccalls@mail.amc.edu
Glick
Stanley D
SD
D000704:Analysis of Variance; D000818:Animals; D016739:Behavior, Addictive / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects*; D007050:Ibogaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012054:Reinforcement, Psychology; D012646:Self Administration; D013997:Time Factors
D018765:Dopamine Uptake Inhibitors; D007050:Ibogaine; D003042:Cocaine; C103345:18-methoxycoronaridine