[Inhibitive effects of Panax notoginseng saponins on expression of Abeta(1-40), Abeta(1-42) protein in SAMP8's brain].
OBJECTIVE
To observe inhibitive effects of Panax notoginseng saponins on expression of Abeta(1-40), Abeta(1-42) protein in SAMP8's brain.


METHODS
Amount of Abeta(1-40), Abeta(1-42 immuno-positive neurons was detected in parietal cortex and hippocamp in their brains under high power lens (40 x) by immunohistochemistry analysis.


RESULTS
PNS could reduce the amount of Abeta(1-40), Abeta(1-42) protein in parietal cortex and hippocamp.


CONCLUSIONS
PNS can reduce the amount of Abeta(1-40), Abeta(1-42) protein in SAMP8's brain.
Zhong
Zhen-guo
ZG
Center of Research & Development of New Drugs, Guangxi Traditional Chinese Medical University, Nanning 530001, China. zhongzg@gxtcmu.edu.cn
Wu
Deng-pan
DP
Wang
Jin-sheng
JS
Wang
Nai-ping
NP
Zhang
Wen-yan
WY
Lv
Liang
L
Qu
Ze-qiang
ZQ
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism; D007150:Immunohistochemistry; D051379:Mice; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology; D053723:Panax notoginseng / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012503:Saponins / Q000494:pharmacology*
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D018696:Neuroprotective Agents; D012503:Saponins