title: Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform.
abstract: We report a chemically modified construct of the Sgc8 aptamer, selected against CEM cells, conjugated to an activator platform for stimulated release of molecules at the tumor surface using DNA template assisted functional group transfer reactions (DTGTR).
authors.affiliation: Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA.
authors.forename: Prabodhika
authors.initials: P
authors.lastname: Mallikaratchy
authors.forename: Haipeng
authors.initials: H
authors.lastname: Liu
authors.forename: Yu Fen
authors.initials: YF
authors.lastname: Huang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Dalia
authors.initials: D
authors.lastname: Lopez-Colon
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
mesh_terms: D052157:Aptamers, Nucleotide; D001483:Base Sequence; D045744:Cell Line, Tumor; D015342:DNA Probes; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D052157:Aptamers, Nucleotide; D015342:DNA Probes