title: [Efficacy of ingavirin in adults with influenza].
abstract: OBJECTIVE
  To compare therapeutic efficacy and safety of ingavirin and arbidol in patients with influenza.
  
  
  METHODS
  The trial included 105 patients with a verified diagnosis of influenza, definite clinical symptoms, body temperature at least 38 degrees C and duration of the disease 36 hours maximum. Ingavirin efficacy was analysed basing on the evidence for 100 patients with uncomplicated influenza. The patients were randomized into three groups: taking ingavirin in a single daily dose 90 mg (n = 33), placebo (n = 36) or arbidol (200 mg 4 times a day). The duration of the treatment was 5 days.
  
  
  RESULTS
  Intake of ingavirin in initial 24-36 hours of the disease significantly reduced fever compared to placebo and arbidol (34.5, 72.0 and 48.4 hours, respectively). Ingavirin was less toxic and had no side effects.
  
  
  CONCLUSIONS
  Ingavirin is safe and effective in the treatment of influenza. By some criteria it is more effective than arbidol.
authors.forename: L V
authors.initials: LV
authors.lastname: Kolobukhina
authors.forename: L N
authors.initials: LN
authors.lastname: Merkulova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Shchelkanov
authors.forename: E I
authors.initials: EI
authors.lastname: Burtseva
authors.forename: E I
authors.initials: EI
authors.lastname: Isaeva
authors.forename: N A
authors.initials: NA
authors.lastname: Malyshev
authors.forename: D K
authors.initials: DK
authors.lastname: L'vov
mesh_terms: D000293:Adolescent; D000328:Adult; D000577:Amides / Q000008:administration & dosage* / Q000009:adverse effects; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002208:Caproates; D003998:Dicarboxylic Acids / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage* / Q000009:adverse effects; D007211:Indoles / Q000008:administration & dosage* / Q000009:adverse effects; D007251:Influenza, Human / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D055815:Young Adult; D013440:Sulfides
chemical_list: D000577:Amides; D000998:Antiviral Agents; D002208:Caproates; D003998:Dicarboxylic Acids; D007093:Imidazoles; D007211:Indoles; C539419:pentanedioic acid imidazolyl ethanamide; C086979:umifenovir; D013440:Sulfides