title: A small molecule diacid with long-term chiral memory.
abstract: A small, axially chiral diacid was designed with chiral memory based on restricted rotation. Heating a racemic sample with a chiral alkaloid led to an enantiomeric excess of up to 40% ee. The guest-induced chirality was preserved on cooling to rt, which was maintained even in the absence of guest (t(1/2) = 14y). The chiral enrichment process was also reversible, allowing the diacid to be used as a chiral switch.
authors.affiliation: Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA.
authors.forename: Roger D
authors.initials: RD
authors.lastname: Rasberry
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Wu
authors.forename: Brooke N
authors.initials: BN
authors.lastname: Bullock
authors.forename: Mark D
authors.initials: MD
authors.lastname: Smith
authors.forename: Ken D
authors.initials: KD
authors.lastname: Shimizu