The structure and function of G-protein-coupled receptors.
G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.
Rosenbaum
Daniel M
DM
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Palo Alto, California 94305, USA.
Rasmussen
Søren G F
SG
Kobilka
Brian K
BK
D000818:Animals; D017124:Conserved Sequence; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D055355:Opsins / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction
D055355:Opsins; D043562:Receptors, G-Protein-Coupled