title: Estrogen receptor-mediated transcriptional activity of genistein in the mouse testis.
abstract: Here we show that genistein, through an estrogen receptor-mediated action, modulates gene expression in the mouse testis throughout development. Genistein passed from the lactating mother to the suckling offspring at levels sufficient to activate gene expression in the testis of the pups. Testis are already responsive to genistein as well as to estradiol at day 14.5 of fetal development. Activation of luciferase correlates with an activation of cell proliferation. In conclusion, our results show that genistein affects reproductive organs of male mice at all developmental ages.
authors.affiliation: Laboratory of Biotechnology, Civic Hospital of Brescia, Brescia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Montani
authors.forename: M
authors.initials: M
authors.lastname: Penza
authors.forename: M
authors.initials: M
authors.lastname: Jeremic
authors.forename: G
authors.initials: G
authors.lastname: Rando
authors.forename: P
authors.initials: P
authors.lastname: Ciana
authors.forename: A
authors.initials: A
authors.lastname: Maggi
authors.forename: G
authors.initials: G
authors.lastname: La Sala
authors.forename: M
authors.initials: M
authors.lastname: De Felici
authors.forename: D
authors.initials: D
authors.lastname: Di Lorenzo
mesh_terms: D000818:Animals; D019833:Genistein / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism*; D046509:Tissue Culture Techniques; D015533:Transcriptional Activation / Q000187:drug effects* / Q000235:genetics*
chemical_list: D011960:Receptors, Estrogen; D019833:Genistein