title: The clinical spectrum of 94 patients carrying a single mutated MEFV allele.
abstract: OBJECTIVE
  To assess the clinical characteristics of patients living in France and carrying a single MEFV mutation.
  
  
  METHODS
  A retrospective chart review of patients referred to us for recurrent fevers. Genetic testing: systematic screening of exons 2 and 10 was performed in the MEFV gene. A subset of patients was also investigated for other auto-inflammatory genes.
  
  
  RESULTS
  We analysed 94 patients (sex ratio:1). Forty-two percent of them were Jews and 17% were Arabs. The median age of onset was 2 years (3 months-47 years). Fever was >39 degrees C in 80% of them, while the duration and frequency of an attack varied (<24 h: 8%; 1-3 days: 56%; >3 days: 36%; >2 months: 15%; 1-2 months: 48%; and <1 month: 37%, respectively). Peritonitis occurred in 97%, pleuritis in 25%, arthralgia in 53%; skin rashes in 20%, aphthosis in 18% and lymphadenopathy in 9%. MEFV mutations were M694V (60%) and M694I (7%). The R92Q TRAPS mutation was retrieved in 3/21 patients tested and the V377I MKD mutation in 1/6. Associated diseases in these patients were periodic fever, aphthosis pharyngitis and adenitis syndrome (4), AS (5), Crohn's disease (2) and Castleman's disease (1).
  
  
  CONCLUSIONS
  The clinical picture of French heterozygote patients with recurrent fevers resembles that of homozygote patients. Most of them required colchicine treatment.
authors.affiliation: Department of Paediatrics and Paediatric Rheumatology, Hôpital de Bicêtre, National Reference Centre for Auto-inflammatory Disorders, Le Kremlin-Bicêtre, France. isabelle.kone-paut@bct.aphp.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Koné-Paut
authors.forename: Véronique
authors.initials: V
authors.lastname: Hentgen
authors.forename: Severine
authors.initials: S
authors.lastname: Guillaume-Czitrom
authors.forename: Sandrine
authors.initials: S
authors.lastname: Compeyrot-Lacassagne
authors.forename: Tu-Anh
authors.initials: TA
authors.lastname: Tran
authors.forename: Isabelle
authors.initials: I
authors.lastname: Touitou
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000686:Amyloidosis / Q000150:complications / Q000235:genetics; D018912:Arabs; D001528:Behcet Syndrome / Q000150:complications / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003078:Colchicine / Q000627:therapeutic use; D003598:Cytoskeletal Proteins / Q000235:genetics*; D010505:Familial Mediterranean Fever / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005602:France; D006074:Gout Suppressants / Q000627:therapeutic use; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007223:Infant; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000235:genetics; D007585:Jews; D008297:Male; D008875:Middle Aged; D009154:Mutation; D000071198:Pyrin; D012189:Retrospective Studies
chemical_list: D003598:Cytoskeletal Proteins; D006074:Gout Suppressants; C000604192:MEFV protein, human; D000071198:Pyrin; D003078:Colchicine