Effects of Glycyrrhiza glabra polysaccharides on immune and antioxidant activities in high-fat mice.
The purpose of this study was to investigate the immune and antioxidant activities of Glycyrrhiza glabra polysaccharides (GGP) in rats fed high-fat diet. The experiment was performed on four groups of growing Kunming mice. The results of the experiment showed a statistically significant decrease in serum antioxidant enzyme activities in high-fat group. Administration of GGP dose-dependently significantly enhanced immune and antioxidant enzyme activities in the GGP-treated mice compared to the high-fat model mice. It is concluded that GGP treatment can enhance immune activities, and reduce oxidative stress in high-fat mice.
Hong
Ying-Kai
YK
Department of Urology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, PR China.
Wu
Hua-Tao
HT
Ma
Tao
T
Liu
Wei-Juan
WJ
He
Xue-Jun
XJ
D000704:Analysis of Variance; D000818:Animals; D001774:Blood Chemical Analysis; D001973:Bromodeoxyuridine; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003208:Concanavalin A; D006035:Glycyrrhiza / Q000737:chemistry*; D007111:Immunity, Cellular / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D010088:Oxidoreductases / Q000378:metabolism; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects
D011134:Polysaccharides; D003208:Concanavalin A; D010088:Oxidoreductases; D001973:Bromodeoxyuridine