title: Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution.
abstract: To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability, various ibuprofen-loaded solid dispersions were prepared with water, HPMC and poloxamer. The effect of HPMC and poloxamer on aqueous solubility of ibuprofen was investigated. The dissolution and bioavailability of solid dispersion in rats were then evaluated compared to ibuprofen powder. When the amount of carrier increased with a decreased in HPMC/poloxamer ratio, the aqueous solubility of ibuprofen was elevated. The solid dispersion composed of ibuprofen/HPMC/poloxamer at the weight ratio of 10:3:2 improved the drug solubility approximately 4 fold. It gave significantly higher initial plasma concentration, AUC and Cmax of drug than did ibuprofen powder in rats. The solid dispersion improved the bioavailability of drug about 4-fold compared to ibuprofen powder. Thus, this ibuprofen-loaded solid dispersion with water, HPMC and poloxamer was a more effective oral dosage form for improving the bioavailability of poor water-soluble ibuprofen.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan, Korea.
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Park
authors.forename: Ram
authors.initials: R
authors.lastname: Kwon
authors.forename: Qi Zhe
authors.initials: QZ
authors.lastname: Quan
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Oh
authors.forename: Jong Oh
authors.initials: JO
authors.lastname: Kim
authors.forename: Ma Ro
authors.initials: MR
authors.lastname: Hwang
authors.forename: Yoon Bon
authors.initials: YB
authors.lastname: Koo
authors.forename: Jong Soo
authors.initials: JS
authors.lastname: Woo
authors.forename: Chul Soon
authors.initials: CS
authors.lastname: Yong
authors.forename: Han-Gon
authors.initials: HG
authors.lastname: Choi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004337:Drug Carriers; D065347:Hypromellose Derivatives; D007052:Ibuprofen / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D020442:Poloxamer / Q000737:chemistry; D011208:Powders; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004304:Dosage Forms; D004337:Drug Carriers; D011208:Powders; D014867:Water; D020442:Poloxamer; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D007052:Ibuprofen