title: Primary follicular dendritic cell sarcoma of the thyroid gland coexisting with Hashimoto's thyroiditis.
abstract: Follicular dendritic cell (FDC) sarcoma, especially of extranodal origin, is an extremely rare malignancy of FDC origin, with only 1 case previously documented in the thyroid. The authors report the case of a 58-year-old female who presented with a painless mass in her neck. The neoplastic cells expressed monocyte/macrophage-specific marker CD68 (KP-1) and lysozymes and the dendritic cell-associated antigens CD35 and Fascin but was negative for CD1a, CD21, and CD23, most consistent with a diagnosis of FDC sarcoma. BIOMED-2 multiplex polymerase chain reaction analysis showed B-cell clonality in both tumor and its adjacent coexisting Hashimoto's thyroiditis. To the authors' knowledge, this is the first report of a rare entity of FDC sarcoma primarily involving the thyroid gland coexisting with Hashimoto's thyroiditis.
authors.affiliation: Pathology, Xi Jing Hospital, 4th Military Medical University, Xi'an, Shaanxi 710032, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yu
authors.forename: Shou Jing
authors.initials: SJ
authors.lastname: Yang
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D002999:Clone Cells; D054740:Dendritic Cell Sarcoma, Follicular / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D050031:Hashimoto Disease / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D008875:Middle Aged; D009113:Muramidase; D017463:Receptors, Complement 3b / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013965:Thyroidectomy; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D008840:Microfilament Proteins; D009113:Muramidase; D017463:Receptors, Complement 3b; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C509991:CR1 protein, human; C020324:fascin