title: GORD in children.
abstract: BACKGROUND
  Gastro-oesophageal regurgitation is considered a problem if it is frequent, persistent, and associated with other symptoms such as increased crying, discomfort with regurgitation, and frequent back arching. A cross-sectional survey of parents of 948 infants attending 19 primary care paediatric practices found that regurgitation of at least one episode a day was reported in 51% of infants aged 0-3 months.
  
  
  METHODS
  We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatment for symptomatic gastro-oesophageal reflux? We searched: Medline, Embase, The Cochrane Library, and other important databases up to August 2007 (BMJ Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
  
  
  RESULTS
  We found 27 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
  
  
  CONCLUSIONS
  In this systematic review we present information relating to the effectiveness and safety of the following interventions: domperidone, feed thickeners in infants, H(2) antagonists, head elevated sleep positioning, left lateral or prone sleep positioning, metoclopramide, proton pump inhibitors, sodium alginate, surgery, soy formula with added fibre, and weight loss.
authors.affiliation: Consultant Paediatrician, Royal Cornwall Hospital, Treliske, Truro, Cornwall, UK.
authors.forename: Yadlapalli
authors.initials: Y
authors.lastname: Kumar
authors.forename: Rajini
authors.initials: R
authors.lastname: Sarvananthan
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D002648:Child; D003430:Cross-Sectional Studies; D004294:Domperidone / Q000627:therapeutic use; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006801:Humans; D015994:Incidence; D007223:Infant; D008787:Metoclopramide / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors; D004294:Domperidone; D008787:Metoclopramide