title: Cutaneous allergy testing in patients suspected of an allergic reaction to eye medication.
abstract: OBJECTIVE
  Our aim was to determine the usefulness of allergy testing in patients with possible allergic reactions to an eye medication.
  
  
  METHODS
  This retrospective study analyzed the usefulness of allergy testing in 90 patients who on the basis of their complaints were under suspicion of having an allergic response to eye medication.
  
  
  RESULTS
  Among the 90 patients suspected of an allergic reaction to eye medication, the most common complaint was itching, while hyperemic conjunctivae were the most common symptom. Skin testing revealed an allergy to eye medication in 32 (36%) of the patients tested, which seemed to be the causal factor of the complaints in 22 cases (24%). The most frequent medication-associated allergies were directed against tobramycin, neomycin sulfate and thimerosal. Clinically relevant non-drug-related allergies occurred in 26 cases and were directed against nickel sulfate, Myroxylon pereirae and fragrance mix. Twenty-three patients were atopic and had positive skin prick tests against inhalation allergens such as house dust mites or dogs.
  
  
  CONCLUSIONS
  Allergy testing was helpful to obtain a diagnosis of a clinically relevant allergy in 48 of the 90 patients who were referred under suspicion of having a contact allergy to eye medication.
authors.affiliation: Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: A L
authors.initials: AL
authors.lastname: Wijnmaalen
authors.forename: E J
authors.initials: EJ
authors.lastname: van Zuuren
authors.forename: R J W
authors.initials: RJ
authors.lastname: de Keizer
authors.forename: M J
authors.initials: MJ
authors.lastname: Jager
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D009355:Neomycin / Q000009:adverse effects; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D012189:Retrospective Studies; D012882:Skin Tests; D013849:Thimerosal / Q000009:adverse effects; D014031:Tobramycin / Q000009:adverse effects
chemical_list: D000900:Anti-Bacterial Agents; D011310:Preservatives, Pharmaceutical; D013849:Thimerosal; D009355:Neomycin; D014031:Tobramycin