[Micafungin in pediatric and adolescent patients].
Micafungin is one of three echinocandins, a novel class of antifungal agents active against 1,3-beta-D glucan in the fungal cell wall. It is a favorable safety profile have made it an attractive option in the treatment of invasive Candida and Aspergillus infections. Available studies have shown that younger children have lower C(max), shorter t(1/2) and faster clearance than adults.
Madero-López
Luis
L
Servicio de Oncohematología y Trasplante Hematopoyético, Hospital Universitario Infantil Niño Jesús, Madrid, España. lmadero.hnjs@salud.madrid.org
D000293:Adolescent; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy*; D002177:Candidiasis / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D026141:Drug Resistance, Multiple, Fungal; D054714:Echinocandins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D016469:Fungemia / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D055666:Lipopeptides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008297:Male; D000077551:Micafungin; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin