title: Vertical arrays of nanofluidic channels fabricated without nanolithography.
abstract: Vertical arrays of sealed nanofluidic channels, in which both cross-sectional dimensions are controllable down to 10 nm, were fabricated by selective side etching of a SiGe heterostructure comprised of layers of alternating Ge fractions. Capillary filling of these nanochannel arrays with fluorescent dye solutions was investigated using a confocal microscope. The feasibility of using nanochannels for size-based separation of biomolecules was demonstrated by imaging aggregates of tagged amyloid-beta peptide. The ability to integrate a large number of nanochannels shows promise for high throughput applications involving lab-on-a-chip systems.
authors.affiliation: L-NESS, Dipartimento di Fisica, Politecnico di Milano, Via Anzani 42, 22100, Como, Italy. roman.sordan@como.polimi.it
authors.forename: Roman
authors.initials: R
authors.lastname: Sordan
authors.forename: Alessio
authors.initials: A
authors.lastname: Miranda
authors.forename: Floriano
authors.initials: F
authors.lastname: Traversi
authors.forename: Davide
authors.initials: D
authors.lastname: Colombo
authors.forename: Daniel
authors.initials: D
authors.lastname: Chrastina
authors.forename: Giovanni
authors.initials: G
authors.lastname: Isella
authors.forename: Massimo
authors.initials: M
authors.lastname: Masserini
authors.forename: Leo
authors.initials: L
authors.lastname: Miglio
authors.forename: Klaus
authors.initials: K
authors.lastname: Kern
authors.forename: Kannan
authors.initials: K
authors.lastname: Balasubramanian
mesh_terms: D016229:Amyloid beta-Peptides / Q000648:ultrastructure; D005456:Fluorescent Dyes / Q000737:chemistry; D005857:Germanium / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D018613:Microscopy, Confocal; D036103:Nanotechnology / Q000295:instrumentation*; D012825:Silicon / Q000737:chemistry; D014741:Video Recording
chemical_list: D016229:Amyloid beta-Peptides; D005456:Fluorescent Dyes; D005857:Germanium; D012825:Silicon