The correlation between GPR30 and clinicopathologic variables in breast carcinomas.
The G-protein-coupled-receptor 30 (GPR30) is a new membrane estrogen receptor. The aim of the present study was to determine the correlations among GPR30, ERalpha, PR, C-erbB-2, p53, TNM stage, and pathologic grade in breast carcinomas. Two hundred forty-one biopsy specimens were evaluated with immunohistochemical assays, and then correlations were analyzed. Low negative correlations of GPR30 with ERalpha (r = -0.144, P<0.05) and PR (r = -0.214, P<0.01) were observed. Associations of GPR30 with C-erbB-2, p53, TNM stage, and pathologic grade were not confirmed. These findings indicated that GPR30 might be an independent prognostic factor in breast carcinomas.
Tu
G
G
Department of General Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Hu
D
D
Yang
G
G
Yu
T
T
D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology*; D047628:Estrogen Receptor alpha / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis
D047628:Estrogen Receptor alpha; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled; D011980:Receptors, Progesterone; C109584:GPER1 protein, human