Two different types of malignant fibrous histiocytomas from pet dogs.
We describe 2 cases of malignant fibrous histiocytomas (MFHs) that spontaneously developed in young pet dogs. To classify these tumors, we applied a panel of antibodies (vimentin, desmin, alpha-SMA, and ED1) and Azan staining for collagen. The MFHs were most consistent with osteoclastlike giant and inflammatory cell types. The first case had positive staining for ED1 and vimentin, and given the osteoclast-like giant cells, calcification sites accompanying peripheral giant cell infiltrates. The latter case, the inflammatory cell type, exhibited a storiform-pleomorphic variant of neoplastic cells, including an ossifying matrix. MFHs are among the most highly aggressive tumors occurring in soft tissue sarcomas in elderly dogs; however, MFHs have been poorly studied from a diagnostic point of view. Herein, we describe the histologic and immunohistologic features of MFHs in detail, thus classifying the subtypes of these tumors.
Do
Sun Hee
SH
Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Korea.
Hong
Il Hwa
IH
Park
Jin Kyu
JK
Ji
Ae Ri
AR
Kim
Tae Hwan
TH
Kwak
Dong Mi
DM
Jeong
Kyu Shik
KS
D000818:Animals; D001706:Biopsy / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology*; D004285:Dogs; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*