title: Postnatal exposure to methyl mercury from fish consumption: a review and new data from the Seychelles Child Development Study.
abstract: BACKGROUND
  Fish is an important source of nutrition worldwide. Fish contain both the neurotoxin methyl mercury (MeHg) and nutrients important for brain development. The developing brain appears to be most sensitive to MeHg toxicity and mothers who consume fish during pregnancy expose their fetus prenatally. Although brain development is most dramatic during fetal life, it continues for years postnatally and additional exposure can occur when a mother breast feeds or the child consumes fish. This raises the possibility that MeHg might influence brain development after birth and thus adversely affect children's developmental outcomes. We reviewed postnatal MeHg exposure and the associations that have been published to determine the issues associated with it and then carried out a series of analyses involving alternative metrics of postnatal MeHg exposure in the Seychelles Child Development Study (SCDS) Main Cohort.
  
  
  METHODS
  The SCDS is a prospective longitudinal evaluation of prenatal MeHg exposure from fish consumption. The Main Cohort includes 779 subjects on whom recent postnatal exposure data were collected at the 6-, 19-, 29-, 66-, and 107-month evaluations. We examined the association of recent postnatal MeHg exposure with multiple 66- and 107-month outcomes and then used three types of alternative postnatal exposure metrics to examine their association with the children's intelligence quotient (IQ) at 107 months of age.
  
  
  RESULTS
  Recent postnatal exposure at 107 months of age was adversely associated with four endpoints, three in females only. One alternative postnatal metric was beneficially associated with 9-year IQ in males only.
  
  
  CONCLUSIONS
  We found several associations between postnatal MeHg biomarkers and children's developmental endpoints. However, as has been the case with prenatal MeHg exposure in the SCDS Main Cohort study, no consistent pattern of associations emerged to support a causal relationship.
authors.affiliation: University of Rochester School of Medicine and Dentistry, Department of Neurology, Rochester, NY, United States. gary_myers@urmc.rochester.edu
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Myers
authors.forename: Sally W
authors.initials: SW
authors.lastname: Thurston
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Pearson
authors.forename: Philip W
authors.initials: PW
authors.lastname: Davidson
authors.forename: Christopher
authors.initials: C
authors.lastname: Cox
authors.forename: Conrad F
authors.initials: CF
authors.lastname: Shamlaye
authors.forename: Elsa
authors.initials: E
authors.lastname: Cernichiari
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Clarkson
mesh_terms: D000375:Aging; D001921:Brain / Q000187:drug effects / Q000254:growth & development; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007223:Infant; D007360:Intelligence / Q000187:drug effects*; D008297:Male; D018811:Maternal Exposure; D008628:Mercury / Q000032:analysis / Q000633:toxicity; D008767:Methylmercury Compounds / Q000633:toxicity*; D008895:Milk, Human / Q000737:chemistry*; D017747:Seafood; D012750:Seychelles
chemical_list: D008767:Methylmercury Compounds; D008628:Mercury; C004925:methylmercuric chloride