title: Incidence and trends of prostate cancer in Karachi South, 1995-2002.
abstract: BACKGROUND
  Cancer prostate (CaP) is a commonly diagnosed cancer in western men, but there is sparse information about the demographics of this malignancy in Pakistan. The study objective was to provide an overview of CaP in Karachi, Pakistan.
  
  
  METHODS
  Epidemiological data of 282 incident CaP cases registered at Karachi Cancer Registry (KCR) during 1st January 1995 to 31st December 2002 were reviewed. Incidence and trends were studied in 2 time periods, 1995-7 and 1998-2002.
  
  
  RESULTS
  In 1995-7, CaP accounted for approximately 3.4% of the cancers in males and ranked 8th in hierarchy with an age standardized incidence rate (ASR) world and crude incidence rate (CIR) per 100,000 of 6.0 and 2.8 respectively. During 1998-2002, CaP accounted 4.6% of the cancers, ranked 4th with an ASR world and CIR per 100,000 of 10.1 and 4.4. Thus an approximate 60% increase was observed between 1995 and 2002. Mean ages of the patients were 67.0 and 67.4 years. Age-specific curves showed a gradual increase in risk from the fifth decade onwards. A marginal down staging was also observed in period 2, more apparent in the more educated Mohajir and Punjabi ethnicities.
  
  
  CONCLUSIONS
  Karachi falls into a low risk region for CaP, with a rapidly increasing incidence and a marginal down staging. The probable reasons for the lower incidence are a low life expectancy, lack of availability or accessibility to health care and lack of public awareness. Implementation of CaP screening and public health education is a necessity today. The low incidence of CaP in Pakistan may be an artefact!
authors.affiliation: Karachi Cancer Registry, Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan. yasmin.bhurgri@gmail.com
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Bhurgri
authors.forename: Naila
authors.initials: N
authors.lastname: Kayani
authors.forename: Shahid
authors.initials: S
authors.lastname: Pervez
authors.forename: Rashida
authors.initials: R
authors.lastname: Ahmed
authors.forename: Imran
authors.initials: I
authors.lastname: Tahir
authors.forename: Muneeza
authors.initials: M
authors.lastname: Afif
authors.forename: Ahmed
authors.initials: A
authors.lastname: Usman
authors.forename: Naveen
authors.initials: N
authors.lastname: Faridi
authors.forename: Imtiaz
authors.initials: I
authors.lastname: Bashir
authors.forename: Asif
authors.initials: A
authors.lastname: Bhurgri
authors.forename: Sheema H
authors.initials: SH
authors.lastname: Hasan
authors.forename: S M H
authors.initials: SM
authors.lastname: Zaidi
mesh_terms: D000368:Aged; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000473:pathology