Local control of the primary tumour in metastatic neuroblastoma.
The previous studies have stressed on the importance of loco-regional control in the management of high-risk neuroblastoma. We searched the Surveillance, Epidemiology and End-Results (SEER) database for patients older than 2years with metastatic neuroblastoma who were diagnosed from 1998 to 2005. We identified 291 patients (mean age, 4.35years). The 5-year survival estimate was 53.2%+/-6.4% for patients who had complete resection of their primary tumours (n=116) and 35.7%+/-4.7% for patients who did not have complete resection (p=0.003). External-beam radiotherapy did not affect survival (p=0.79); this finding has to be taken with caution due to the study limitations.
Sultan
Iyad
I
Department of Pediatric Oncology, King Hussein Cancer Centre (KHCC), Al-Jubeiha, Amman, Jordan. isultan@khcc.jo
Ghandour
Khalil
K
Al-Jumaily
Usama
U
Hashem
Sameh
S
Rodriguez-Galindo
Carlos
C
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery*; D012042:Registries; D012186:Retroperitoneal Neoplasms / Q000532:radiotherapy / Q000601:surgery; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology