title: Pharmacological optimization of tissue perfusion.
abstract: After fluid resuscitation, vasoactive drug treatment represents the major cornerstone for correcting any major impairment of the circulation. However, debate still rages as to the choice of agent, dose, timing, targets, and monitoring modalities that should optimally be used to benefit the patient yet, at the same time, minimize harm. This review highlights these areas and some new pharmacological agents that broaden our therapeutic options.
authors.affiliation: Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute for Biomedical Research and Department of Medicine, University College London, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Mongardon
authors.forename: A
authors.initials: A
authors.lastname: Dyson
authors.forename: M
authors.initials: M
authors.lastname: Singer
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002316:Cardiotonic Agents / Q000009:adverse effects / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects*; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods; D010101:Oxygen Consumption / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D002316:Cardiotonic Agents; D014662:Vasoconstrictor Agents