[Parameters of high definition ECG and dispersion ECG mapping on the background of amlodipin and myostimulation during 7-day dry immersion].
The article presents the results of studying electrophysiological changes in the myocardium of normal human subjects during 7-day dry immersion, and modification of the reaction to immersion by amlodipin and myostimulation. The dry immersion effects on the myocardium generally include a succession of electrophysiological shifts first in the ventricles and then in the left atrium due to, probably, blood pooling in the pulmonary vessels. Myostimulation and amlodipin affect the myocardium reaction visibly suggesting involvement of numerous components of the autonomous and central nervous systems. The positive effect of the pharmaceutical--alleviation of myocardium strain--is a result of amlodipin assistance to the coronary blood flow; however, it has a side-effect on orthostatic stability. The positive action of myostimulation is associated with unloading of the right heart and reflected in changed HD ECG parameters and growth of the "myocardium" index.
Eshmanova
A K
AK
Ivanov
G G
GG
Kabulova
A Z
AZ
Luchitskaia
E S
ES
Baevskiĭ
R M
RM
D000328:Adult; D017311:Amlodipine / Q000494:pharmacology*; D004558:Electric Stimulation / Q000379:methods; D004562:Electrocardiography / Q000187:drug effects / Q000379:methods*; D005500:Follow-Up Studies; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007101:Immersion / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000503:physiopathology; D012016:Reference Values; D014665:Vasodilator Agents / Q000494:pharmacology*; D055815:Young Adult
D014665:Vasodilator Agents; D017311:Amlodipine