title: Fetal heart rate tracing patterns associated with congenital hypothyroidism.
abstract: OBJECTIVE
  This study was undertaken to determine fetal heart rate (FHR) tracing patterns associated with congenital hypothyroidism.
  
  
  METHODS
  FHR patterns of 59 women whose babies were diagnosed with congenital hypothyroidism were retrospectively compared with tracings of 78 of their siblings. Tracings were interpreted during the first stage of labor. Multivariable analysis was used to control for confounders.
  
  
  RESULTS
  Neonates with congenital hypothyroidism had significantly higher rates of reduced variability in FHR tracing patterns as compared with those without congenital hypothyroidism (49.2% vs 3.8%; odds ratio, 24.1; 95% confidence interval, 6.8-85.3; P < .001). No significant differences were noted between the groups regarding decelerations or baseline abnormalities. The significant association between congenital hypothyroidism and reduced variability persisted after controlling for confounders such as treatment with pethidine, MgSO4, and gestational age (odds ratio, 14.1; 95% confidence interval, 1.1-190.7; P = .046).
  
  
  CONCLUSIONS
  Congenital hypothyroidism is significantly and independently associated with reduced variability in FHR tracing patterns.
authors.affiliation: Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Iris
authors.initials: I
authors.lastname: Shoham
authors.forename: Barak
authors.initials: B
authors.lastname: Aricha-Tamir
authors.forename: Adi Y
authors.initials: AY
authors.lastname: Weintraub
authors.forename: Moshe
authors.initials: M
authors.lastname: Mazor
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznitzer
authors.forename: Gershon
authors.initials: G
authors.lastname: Holcberg
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
mesh_terms: D015148:Cardiotocography; D016022:Case-Control Studies; D015897:Comorbidity; D003409:Congenital Hypothyroidism / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D006340:Heart Rate, Fetal / Q000502:physiology*; D006801:Humans; D007747:Labor Stage, First / Q000502:physiology*; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies