Autophagy is required for extension of yeast chronological life span by rapamycin.
Rapamycin is an antibiotic that stimulates autophagy in a wide variety of eukaryotes, including the budding yeast Saccharomyces cerevisiae. Low concentrations of rapamycin extend yeast chronological life span (CLS). We have recently shown that autophagy is required for chronological longevity in yeast, which is attributable in part to a role for autophagy in amino acid homeostasis. We report herein that low concentrations of rapamycin stimulate macroautophagy during chronological aging and extend CLS.
Alvers
Ashley L
AL
Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.
Wood
Michael S
MS
Hu
Doreen
D
Kaywell
Amelia C
AC
Dunn
William A
WA
Aris
John P
JP
D001343:Autophagy / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D020123:Sirolimus / Q000494:pharmacology*; D013997:Time Factors
D020123:Sirolimus