Efficacy of liposomal amphotericin B combined with gamma interferon or granulocyte-macrophage colony-stimulating factor for treatment of systemic zygomycosis in mice.
Granulocyte-macrophage colony-stimulating factor enhanced the efficacy of liposomal amphotericin B (LAMB) in a murine model of disseminated infection by Rhizopus oryzae, significantly prolonging survival and reducing tissue burden. The use of gamma interferon (IFN-gamma) alone was ineffective, and IFN-gamma combined with LAMB did not improve the results obtained with LAMB alone.
Rodríguez
M Mar
MM
Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.
Calvo
Enrique
E
Mariné
Marçal
M
Pastor
F Javier
FJ
Fernandez-Ballart
Joan
J
Guarro
Josep
J
D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D012233:Rhizopus / Q000502:physiology; D020096:Zygomycosis / Q000188:drug therapy* / Q000382:microbiology
D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor