Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice.
The mechanism of the analgesic effect of nitrous oxide (N(2)O) has not been completely clarified. Although we have reported that the analgesic effect of N(2)O was significantly decreased in nociceptin-orphanin FQ (N/OFQ) receptor (NOP)-deficient mice, the effect of nociceptin receptor antagonists on N(2)O-induced analgesia has not been reported. In this investigation, we examined the effect of the NOP antagonist JTC-801 on N(2)O-induced analgesia in 129Sv mice by the writhing test and tail flick test, and demonstrated that the analgesic effect of N(2)O was suppressed by the intraperitoneal administration of JTC-801.
Koyama
Tomohiro
T
Department of Anesthesia, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Fukuda
Kazuhiko
K
D019342:Acetic Acid; D000634:Aminoquinolines / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009292:Narcotic Antagonists; D009609:Nitrous Oxide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor
D000634:Aminoquinolines; D018685:Anesthetics, Inhalation; D001549:Benzamides; C433236:N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D009609:Nitrous Oxide; D019342:Acetic Acid; D000094942:Nociceptin Receptor; C000722287:Oprl1 protein, mouse