title: Reducing the boosting dose of ritonavir does not affect saquinavir plasma concentrations in HIV-1-infected individuals.
abstract: Currently, the optimal boosting dose for saquinavir is unknown. Therefore, we evaluated the pharmacokinetics profiles in a cross over setting comparing saquinavir/ritonavir 1500/50 mg (plus NRTI backbone) to saquinavir/ritonavir 1500/100 mg in the same HIV-infected, Thai individuals. The 50% reduction of ritonavir boosting did not result in a change in the pharmacokinetics of saquinavir, whereas the ritonavir exposure was significantly lower when a dose of 50 mg was administered.
authors.affiliation: The HIV Netherlands Australia Thailand Research Collaboration, Bangkok, Thailand. jasper.v@hivnat.org
authors.forename: Jasper
authors.initials: J
authors.lastname: van der Lugt
authors.forename: Meena
authors.initials: M
authors.lastname: Gorowara
authors.forename: Anchalee
authors.initials: A
authors.lastname: Avihingsanon
authors.forename: David
authors.initials: D
authors.lastname: Burger
authors.forename: Jintanat
authors.initials: J
authors.lastname: Ananworanich
authors.forename: Kancharat
authors.initials: K
authors.lastname: Sringam
authors.forename: Stephen
authors.initials: S
authors.lastname: Kerr
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Wit
authors.forename: Joep
authors.initials: J
authors.lastname: Lange
authors.forename: Kiat
authors.initials: K
authors.lastname: Ruxrungtham
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019438:Ritonavir / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D019258:Saquinavir / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D019380:Anti-HIV Agents; D019258:Saquinavir; D019438:Ritonavir