title: Evaluation of antihyperglycemia and antihypertension potential of native Peruvian fruits using in vitro models.
abstract: Local food diversity and traditional crops are essential for cost-effective management of the global epidemic of type 2 diabetes and associated complications of hypertension. Water and 12% ethanol extracts of native Peruvian fruits such as Lucuma (Pouteria lucuma), Pacae (Inga feuille), Papayita arequipeña (Carica pubescens), Capuli (Prunus capuli), Aguaymanto (Physalis peruviana), and Algarrobo (Prosopis pallida) were evaluated for total phenolics, antioxidant activity based on 2, 2-diphenyl-1-picrylhydrazyl radical scavenging assay, and functionality such as in vitro inhibition of alpha-amylase, alpha-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potential management of hyperglycemia and hypertension linked to type 2 diabetes. The total phenolic content ranged from 3.2 (Aguaymanto) to 11.4 (Lucuma fruit) mg/g of sample dry weight. A significant positive correlation was found between total phenolic content and antioxidant activity for the ethanolic extracts. No phenolic compound was detected in Lucuma (fruit and powder) and Pacae. Aqueous extracts from Lucuma and Algarrobo had the highest alpha-glucosidase inhibitory activities. Papayita arequipeña and Algarrobo had significant ACE inhibitory activities reflecting antihypertensive potential. These in vitro results point to the excellent potential of Peruvian fruits for food-based strategies for complementing effective antidiabetes and antihypertension solutions based on further animal and clinical studies.
authors.affiliation: Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciencias Farmaceuticas, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Marcia Da Silva
authors.initials: Mda S
authors.lastname: Pinto
authors.forename: Lena Galvez
authors.initials: LG
authors.lastname: Ranilla
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Apostolidis
authors.forename: Franco Maria
authors.initials: FM
authors.lastname: Lajolo
authors.forename: Maria Inés
authors.initials: MI
authors.lastname: Genovese
authors.forename: Kalidas
authors.initials: K
authors.lastname: Shetty
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D007202:Indicators and Reagents; D019684:Magnoliopsida / Q000737:chemistry; D008519:Medicine, Traditional; D010568:Peru; D010636:Phenols / Q000032:analysis / Q000494:pharmacology*; D010851:Picrates; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D007202:Indicators and Reagents; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl