[Experimental research on the relationship between GATA-3 and ICAM-1 in patients with allergic rhinitis].
OBJECTIVE
To explore the relationship between GATA-3 and ICAM-1 in patients with allergic rhinitis.


METHODS
The expression of GATA-3 was detected by reverse transcriptase polymerase chain reaction (RT-PCR) in 37 patients with allergic rhinitis and 12 controls. ICAM-1 was determined by enzyme-linked immunosorbent assay.


RESULTS
The relative density ratio of GATA-3 to GAPDH in AR patients was 0.632 +/- 0.121, and in control group was 0.131 +/- 0.024. The concentrations of ICAM-1 were (237.5 +/- 37.3) pg/mg and (121.7 +/- 22.4) pg/mg in the two groups respectively. The expression of GATA-3 was positively correlated to the expression of ICAM-1 in patients with allergic rhinitis.


CONCLUSIONS
The overexpression of GATA-3 in patients with allergic rhinitis was related to the increase of ICAM-1. GATA-3 may play an important role in the pathogenesis of allergic rhinitis.
Yao
Jun
J
Department of Otolaryngology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China. firefoxjun@126.com
Xu
Mei
M
Zhang
Yuefei
Y
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D050990:GATA3 Transcription Factor / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism; D055815:Young Adult
D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D018799:Intercellular Adhesion Molecule-1