Ablation of klotho and premature aging: is 1,25-dihydroxyvitamin D the key middleman?
The reversal of soft-tissue abnormalities and prolonged lifespan observed in klotho(-/-) mice following genetic inactivation of 1alpha-hydroxylase underscores the pathophysiological role of 1,25-dihydroxyvitamin D in mediating some of the premature aging-like features observed in klotho(-/-) mice.
Wong
Yuen Fei
YF
King's College London, Department of Renal Medicine, Rayne Institute, London, UK.
Xu
Qihe
Q
King's College London, Department of Renal Medicine, Rayne Institute, London, UK. Electronic address: qihe.xu@kcl.ac.uk.
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000172:deficiency / Q000235:genetics; D019588:Aging, Premature / Q000209:etiology*; D000818:Animals; D020868:Gene Silencing; D005966:Glucuronidase / Q000172:deficiency / Q000235:genetics*; D000090265:Klotho Proteins; D008136:Longevity; D051379:Mice; D018345:Mice, Knockout; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000502:physiology
D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase; D005966:Glucuronidase; D000090265:Klotho Proteins