title: Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis.
abstract: OBJECTIVE
  To characterize the differences in various risk factors for atherosclerosis between individuals with apoB higher (H) and lower (L) than predicted from regression equation apoB vs LDL-C.
  
  
  METHODS
  We evaluated 391 dyslipidemic subjects not treated with hypolipidemic drugs. The measured parameters included lipid profile, apolipoproteins A-1 and B, markers of insulin resistance and inflammation/hemostasis.
  
  
  RESULTS
  Correlation coefficient between apoB and LDL-C was 0.9 (p<0.0001). Individuals with H apoB compared to L apoB had significantly higher sex and age adjusted BMI, waist circumference, insulin, HOMA (fasting insulinglucose/22.5), C-peptide, proinsulin, PAI-1, sICAM-1, sVCAM-1, t-PA, vWF, frequency of metabolic syndrome and lower values of TC, LDL-C and HDL-C (p<0.05 to <0.001 for all parameters).
  
  
  CONCLUSIONS
  Individuals with apoB higher than predicted by their LDL-C levels are more insulin resistant and have more atherogenic risk profile. Thus, at least for dyslipidemic patients with high cardiometabolic risk, apoB is a more appropriate marker of risk than LDL-C.
authors.affiliation: 3rd Department of Internal Medicine, University Hospital Olomouc, Czech Republic. helena.vaverkova@fnol.cz
authors.forename: Helena
authors.initials: H
authors.lastname: Vaverkova
authors.forename: David
authors.initials: D
authors.lastname: Karasek
authors.forename: Dalibor
authors.initials: D
authors.lastname: Novotny
authors.forename: Dagmar
authors.initials: D
authors.lastname: Jackuliakova
authors.forename: Jiri
authors.initials: J
authors.lastname: Lukes
authors.forename: Milan
authors.initials: M
authors.lastname: Halenka
authors.forename: Jiri
authors.initials: J
authors.lastname: Frohlich
mesh_terms: D000328:Adult; D001055:Apolipoproteins B / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D008875:Middle Aged; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D001055:Apolipoproteins B; D015415:Biomarkers; D008078:Cholesterol, LDL