title: In vitro activities of fluconazole, itraconazole and voriconazole against otomycotic fungal pathogens.
abstract: OBJECTIVE
  To determine the causative pathogens of otomycosis, and to evaluate the in vitro activity of antifungal agents against these pathogens.
  
  
  METHODS
  A total of 96 fungal isolate were taken from 92 patients suspected of otomycosis. The in vitro activity of fluconazole, itraconazole and voriconazole against otomycotic pathogens was tested using the E-test method.
  
  
  RESULTS
  The most common pathogen was Aspergillus fumigatus (40.6 per cent), followed by A niger (35.4 per cent), A flavus (12.5 per cent) and Candida albicans (11.5 per cent). All Aspergillus species were found to be resistant to fluconazole (minimum inhibitory concentration > or =256 microg/ml). The mean minimum inhibitory concentrations of voriconazole for A fumigatus, A niger, A flavus and C albicans were significantly lower than those of itraconazole for the same pathogens.
  
  
  CONCLUSIONS
  This study found that the most common otomycotic fungal pathogen was A fumigatus, and that voriconazole had more potent in vitro activity than itraconazole against all Aspergillus species as well as against C albicans.
authors.affiliation: Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Yenişehirli
authors.forename: Y
authors.initials: Y
authors.lastname: Bulut
authors.forename: M
authors.initials: M
authors.lastname: Güven
authors.forename: E
authors.initials: E
authors.lastname: Günday
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy*; D015169:Colony Count, Microbial; D004427:Ear Diseases / Q000382:microbiology*; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D016896:Treatment Outcome; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D015725:Fluconazole; D065819:Voriconazole