title: Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women.
abstract: Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 microg/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects.
authors.affiliation: Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.
authors.forename: Yoon Jung
authors.initials: YJ
authors.lastname: Yang
authors.forename: Yun-Chul
authors.initials: YC
authors.lastname: Hong
authors.forename: Se-Young
authors.initials: SY
authors.lastname: Oh
authors.forename: Min-Seon
authors.initials: MS
authors.lastname: Park
authors.forename: Ho
authors.initials: H
authors.lastname: Kim
authors.forename: Jong-Han
authors.initials: JH
authors.lastname: Leem
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Ha
mesh_terms: D001559:Benzhydryl Compounds; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000633:toxicity* / Q000652:urine; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000139:chemically induced*; D007723:Korea; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D015999:Multivariate Analysis; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000633:toxicity* / Q000652:urine; D017698:Postmenopause / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011795:Surveys and Questionnaires; D014505:Urban Population; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D015415:Biomarkers; D002097:C-Reactive Protein; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds