title: Hepatocellular carcinoma and Crohn's disease: a case report and review.
abstract: Hepatocellular carcinoma (HCC) is usually known to develop in patients with underlying high-risk liver diseases such as viral hepatitis, cirrhosis and alcohol abuse, whereas reports dealing with HCC in Crohn's disease (CD) are limited. We present a case of HCC, which developed sequentially within a short period in a 52-year-old Japanese man with a 36-year history of CD without risky conditions for HCC. He also had not taken immunosuppressants such as azathioprine. Although the definitive etiological factors contributing to hepatocarcinogenesis in the present case could not be elucidated, further close surveillance is required.
authors.affiliation: Department of Internal Medicine, Social Insurance Central General Hospital, Tokyo. h.miura@shahochu.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miura
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Takazoe
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Kitamura
authors.forename: Haruki
authors.initials: H
authors.lastname: Yamada
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D003424:Crohn Disease / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors