title: New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality.
abstract: BACKGROUND
  The database of the German programme for quality in healthcare including data of every hospitalised patient with community-acquired pneumonia (CAP) during a 2-year period (n = 388 406 patients in 2005 and 2006) was analysed.
  
  
  METHODS
  End points of the analysis were: (1) incidence; (2) outcome; (3) performance of the CRB-65 (C, mental confusion; R, respiratory rate >or=30/min; B, systolic blood pressure <90 mm Hg or diastolic blood pressure <or=60 mm Hg; 65, age >or=65 years) score in predicting death; and (4) lack of ventilatory support as a possible indicator of treatment restrictions. The CRB-65 score was calculated, resulting in three risk classes (RCs).
  
  
  RESULTS
  The incidence of hospitalised CAP was 2.75 and 2.96 per 1000 inhabitants/year in 2005 and 2006, respectively, higher for males (3.21 vs 2.52), and strongly age related, with an incidence of 7.65 per 1000 inhabitants/year in patients aged >or=60 years over 2 years. Mortality (13.72% and 14.44%) was higher than reported in previous studies. The CRB-65 RCs accurately predicted death in a three-class pattern (mortality 2.40% in CRB-65 RC 1, 13.43% in CRB-65 RC 2 and 34.39% in CRB-65 RC 3). The first days after admission were consistently associated with the highest risk of death throughout all risk classes. Only a minority of patients who died had received mechanical ventilation during hospitalisation (15.74%).
  
  
  CONCLUSIONS
  Hospitalised CAP basically is a condition of the elderly associated with a higher mortality than previously reported. It bears a considerable risk of early mortality, even in low risk patients. CRB-65 is a simple and powerful tool for the assessment of CAP severity. Hospitalised CAP is a frequent terminal event in chronic debilitated patients, and a limitation of treatment escalation is frequently applied.
authors.affiliation: Thoraxzentrum Ruhrgebiet, Kliniken für Pneumologie und Infektiologie, Herne und Bochum, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Ewig
authors.forename: N
authors.initials: N
authors.lastname: Birkner
authors.forename: R
authors.initials: R
authors.lastname: Strauss
authors.forename: E
authors.initials: E
authors.lastname: Schaefer
authors.forename: J
authors.initials: J
authors.lastname: Pauletzki
authors.forename: H
authors.initials: H
authors.lastname: Bischoff
authors.forename: P
authors.initials: P
authors.lastname: Schraeder
authors.forename: T
authors.initials: T
authors.lastname: Welte
authors.forename: G
authors.initials: G
authors.lastname: Hoeffken
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000628:therapy; D016208:Databases, Factual; D004812:Epidemiologic Methods; D005260:Female; D005858:Germany / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000453:epidemiology* / Q000628:therapy; D011379:Prognosis; D011787:Quality of Health Care; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D017678:Sex Distribution; D016896:Treatment Outcome; D055815:Young Adult