Nucleotide variation in central nervous system genes among male suicide attempters.
Despite marked morbidity and mortality associated with suicidal behavior, accurate identification of individuals at risk remains elusive. The goal of this study is to identify a model based on single nucleotide polymorphisms (SNPs) that discriminates between suicide attempters and non-attempters using data mining strategies. We examined functional SNPs (n = 840) of 312 brain function and development genes using data mining techniques. Two hundred seventy-seven male psychiatric patients aged 18 years or older were recruited at a University hospital psychiatric emergency room or psychiatric short stay unit. The main outcome measure was history of suicide attempts. Three SNPs of three genes (rs10944288, HTR1E; hCV8953491, GABRP; and rs707216, ACTN2) correctly classified 67% of male suicide attempters and non-attempters (0.50 sensitivity, 0.82 specificity, positive likelihood ratio = 2.80, negative likelihood ratio = 1.64). The OR for the combined three SNPs was 4.60 (95% CI: 1.31-16.10). The model's accuracy suggests that in the future similar methodologies may generate simple genetic tests with diagnostic utility in identification of suicide attempters. This strategy may uncover new pathophysiological pathways regarding the neurobiology of suicidal acts.
Baca-Garcia
Enrique
E
Department of Psychiatry at Fundacion Jimenez Diaz Hospital, Autonoma University, Madrid, Spain. eb2452@columbia.edu
Vaquero-Lorenzo
Concepción
C
Perez-Rodriguez
M Mercedes
MM
Gratacòs
Mònica
M
Bayés
Mònica
M
Santiago-Mozos
Ricardo
R
Leiva-Murillo
Jose Miguel
JM
de Prado-Cumplido
Mario
M
Artes-Rodriguez
Antonio
A
Ceverino
Antonio
A
Diaz-Sastre
Carmen
C
Fernandez-Navarro
Pablo
P
Costas
Javier
J
Fernandez-Piqueras
José
J
Diaz-Hernandez
Montserrat
M
de Leon
Jose
J
Baca-Baldomero
Enrique
E
Saiz-Ruiz
Jeronimo
J
Mann
J John
JJ
Parsey
Ramin V
RV
Carracedo
Angel
A
Estivill
Xavier
X
Oquendo
Maria A
MA
D000328:Adult; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012680:Sensitivity and Specificity; D013406:Suicide, Attempted