title: No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort.
abstract: A recent genome-wide association study (GWAS) found significant association of six single nucleotide polymorphisms (SNPs) in the gene FLJ10986 with sporadic amyotrophic lateral sclerosis (SALS). Another independent GWAS reported significant association of one SNP in the gene inositol 1,4,5-triphosphate receptor 2 (ITPR2) with SALS. These studies provided conflicting results. We examined the six most significant SNPs in FLJ10986 and one SNP in ITPR2 in a large cohort consisting of 595 SALS cases and 681 controls ascertained from Germany. Our results did not provide evidence for the association of these SNPs with SALS, suggesting a possible population-specific effect for FLJ10986 and ITPR2 that do not modulate the risk for SALS in the German population.
authors.affiliation: Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Otfried-Müller-Strasse 27, 72076, Tuebingen, Germany.
authors.forename: Rubén
authors.initials: R
authors.lastname: Fernández-Santiago
authors.forename: Manu
authors.initials: M
authors.lastname: Sharma
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: Johanna
authors.initials: J
authors.lastname: Anneser
authors.forename: Thomas
authors.initials: T
authors.lastname: Meyer
authors.forename: Albert
authors.initials: A
authors.lastname: Ludolph
authors.forename: Thomas
authors.initials: T
authors.lastname: Gasser
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D055106:Genome-Wide Association Study; D005858:Germany / Q000453:epidemiology; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011506:Proteins / Q000235:genetics*
chemical_list: C547127:FGGY protein, human; C506927:ITPR2 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D011506:Proteins