title: Mutation accumulation, soft selection and the middle-class neighborhood.
abstract: The "middle-class neighborhood" is a breeding design intended to allow new mutations to accumulate by lessening the effects of purifying selection through the elimination of among-line fitness variation. We show that this design effectively applies soft selection to the experimental population, potentially causing biased estimates of mutational effects if social effects contribute to fitness.
authors.affiliation: Department of Genetics, University of Georgia, Athens, Georgia 30602-7223, USA. jmoorad@uga.edu
authors.forename: Jacob A
authors.initials: JA
authors.lastname: Moorad
authors.forename: David W
authors.initials: DW
authors.lastname: Hall
mesh_terms: D000818:Animals; D001947:Breeding; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D012641:Selection, Genetic; D012924:Social Conditions