Synthesis of functionalized indenes via cascade reaction of aziridines and propargyl alcohols.
A concise synthesis of functionalized indenes via the Lewis acid catalyzed cascade reaction of aziridines and propargylic alcohols has been developed. The methodology offers great potential for the synthesis of biologically active indene derivatives and related polycyclic compounds.
Wang
Shaoyin
S
Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China.
Zhu
Yuanxun
Y
Wang
Yanguang
Y
Lu
Ping
P
D000480:Alkynes / Q000737:chemistry*; D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000480:Alkynes; D001388:Aziridines; D007192:Indenes; D011083:Polycyclic Compounds; D020005:Propanols; C028255:propargyl alcohol