title: Studies in acyl C-H activation via aryl and alkyl to acyl "through space" migration of palladium.
abstract: Examples of the 1,4-migration of a palladium moiety in aryl- and alkylpalladium intermediates to the acyl position of an aldehyde or formamide have been observed. The resulting acylpalladium intermediate can undergo ester or carbamate formation by reaction with an alcohol; decarbonylation, followed by beta hydride elimination to an alkene; reaction with an organomercurial to form an ester; or alkene insertion. Deuterium-labeling studies have been used to confirm the palladium migration mechanism.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Tanay
authors.initials: T
authors.lastname: Kesharwani
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Verma
authors.forename: Daniel
authors.initials: D
authors.lastname: Emrich
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Ward
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock