title: Direct catalytic asymmetric Mannich-type reaction of thioamides.
abstract: Taking the reins: The title transformation of thioamides and N-diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme). Divergent transformation of the thioamide functionality highlights the utility of this methodology.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Ryo
authors.initials: R
authors.lastname: Yazaki
authors.forename: Naoya
authors.initials: N
authors.lastname: Kumagai
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Shibasaki
mesh_terms: D002384:Catalysis; D007097:Imines / Q000737:chemistry; D008352:Mannich Bases / Q000737:chemistry; D013237:Stereoisomerism; D013854:Thioamides / Q000737:chemistry*
chemical_list: D007097:Imines; D008352:Mannich Bases; D013854:Thioamides