title: Effects of Tityus serrulatus scorpion venom on lung mechanics and  inflammation in mice.
abstract: The present study evaluated the effects of an intramuscular injection of Tityus serrulatus venom (TsV) (0.67 miocrog/g) on lung mechanics and lung inflammation at 15, 30, 60 and 180 min after inoculation. TsV inoculation resulted in increased lung elastance when compared with the control group (p < 0.001); these values were significantly higher at 60 min than at 15 and 180 min (p < 0.05). Resistive pressure (DeltaP1) values decreased significantly at 30, 60 and 180 min after TsV injection (p < 0.001). TsV inoculation resulted in increased lung inflammation, characterised by an increased density of mononuclear cells at 15, 30, 60 and 180 min after TsV injection when compared with the control group (p < 0.001). TsV inoculation also resulted in an increased pulmonary density of polymorphonuclear cells at 15, 30 and 60 min following injection when compared to the control group (p < 0.001). In conclusion, T. serrulatus venom leads to acute lung injury, characterised by altered lung mechanics and increased pulmonary inflammation.
authors.affiliation: Laboratory of Physiology and Pharmacodynamics, Research and Development Institute, University of Vale do Paraiba - UNIVAP, Sao Jose dos Campos, SP, Brazil.
authors.forename: Ana Claudia
authors.initials: AC
authors.lastname: Paneque Peres
authors.forename: Paula Naomi
authors.initials: PN
authors.lastname: Nonaka
authors.forename: Paulo de Tarso Camillo
authors.initials: Pde T
authors.lastname: de Carvalho
authors.forename: Marcos Hikari
authors.initials: MH
authors.lastname: Toyama
authors.forename: Cesar Augusto Melo e
authors.initials: CA
authors.lastname: Silva
authors.forename: Rodolfo de Paula
authors.initials: RP
authors.lastname: Vieira
authors.forename: Marisa
authors.initials: M
authors.lastname: Dolhnikoff
authors.forename: Stella Regina
authors.initials: SR
authors.lastname: Zamuner
authors.forename: Luis Vicente Franco
authors.initials: LV
authors.lastname: de Oliveira
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D004548:Elasticity; D007202:Indicators and Reagents; D007273:Injections, Intramuscular; D007928:Lethal Dose 50; D008168:Lung / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051379:Mice; D020556:Neutrophil Infiltration / Q000187:drug effects; D011014:Pneumonia / Q000139:chemically induced* / Q000473:pathology*; D015656:Respiratory Mechanics / Q000187:drug effects*; D012604:Scorpion Venoms / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D007202:Indicators and Reagents; D012604:Scorpion Venoms