In vivo differentiation of two vessel wall layers in lower extremity peripheral vein bypass grafts: application of high-resolution inner-volume black blood 3D FSE.
Lower extremity peripheral vein bypass grafts (LE-PVBG) imaged with high-resolution black blood three-dimensional (3D) inner-volume (IV) fast spin echo (FSE) MRI at 1.5 Tesla possess a two-layer appearance in T1W images while only the inner layer appears visible in the corresponding T2W images. This study quantifies this difference in six patients imaged 6 months after implantation, and attributes the difference to the T(2) relaxation rates of vessel wall tissues measured ex vivo in two specimens with histologic correlation. The visual observation of two LE-PVBG vessel wall components imaged in vivo is confirmed to be significant (P < 0.0001), with a mean vessel wall area difference of 6.8 +/- 2.7 mm(2) between contrasts, and a ratio of T1W to T2W vessel wall area of 1.67 +/- 0.28. The difference is attributed to a significantly (P < 0.0001) shorter T(2) relaxation in the adventitia (T(2) = 52.6 +/- 3.5 ms) compared with the neointima/media (T(2) = 174.7 +/- 12.1 ms). Notably, adventitial tissue exhibits biexponential T(2) signal decay (P < 0.0001 vs monoexponential). Our results suggest that high-resolution black blood 3D IV-FSE can be useful for studying the biology of bypass graft wall maturation and pathophysiology in vivo, by enabling independent visualization of the relative remodeling of the neointima/media and adventitia.
Mitsouras
Dimitris
D
Department of Radiology, Applied Imaging Science Laboratory, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. dmitsouras@alum.mit.edu
Owens
Christopher D
CD
Conte
Michael S
MS
Ersoy
Hale
H
Creager
Mark A
MA
Rybicki
Frank J
FJ
Mulkern
Robert V
RV
D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D035002:Lower Extremity / Q000098:blood supply / Q000473:pathology; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000473:pathology* / Q000601:surgery*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014680:Veins / Q000473:pathology* / Q000637:transplantation*