Repenins A-D, four new antioxidative coumarinolignoids from Duranta repens Linn.
Phytochemical investigations on the CHCl(3)-soluble fraction of the whole plant of Duranta repens Linn. led to the isolation of four new coumarinolignoids, Repenins A-D (1-4), along with the known coumarinolignoids, cleomiscosin A (5) and durantin A (6). Their structures were determined by modern spectroscopic analysis including 1D and 2D NMR techniques and chemical studies. The compounds (1-6) showed potent antioxidative scavenging activity against DPPH radicals, with IC(50) values in the range 0.420-0.625mM. Repenin B (2) displayed the strongest scavenging potential with IC(50) values of (0.420mM).
Ahmad
Nisar
N
Department of Plant Sciences, Kohat University of Science and Technology, Kohat-26000, N.W.F.P., Pakistan.
Zeb
Fozia
F
Ahmad
Ijaz
I
Wang
Fanghai
F
D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D029648:Verbenaceae / Q000737:chemistry*
D003374:Coumarins; D016166:Free Radical Scavengers; D010936:Plant Extracts; C041934:cleomiscosin A