title: Balancing risks and benefits of cyclooxygenase-2 selective nonsteroidal anti-inflammatory drugs.
abstract: Choosing NSAID therapy remains confusing and controversial-the challenge for the clinician is to sum all the risks as well as analgesic and anti-inflammatory efficacy. COX-2 inhibitors are an important scientific advance in pain therapy, and using them in a safe and cost-effective manner is possible when all the competing risks are carefully weighed.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, University of Michigan School of Medicine, 3912 Taubman Center SPC 5362, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. jscheima@umich.edu
authors.forename: James M
authors.initials: JM
authors.lastname: Scheiman
mesh_terms: D000367:Age Factors; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000453:epidemiology; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D010146:Pain / Q000188:drug therapy; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D054328:Proton Pump Inhibitors