Effects of Tityus serrulatus scorpion venom on lung mechanics and  inflammation in mice.
The present study evaluated the effects of an intramuscular injection of Tityus serrulatus venom (TsV) (0.67 miocrog/g) on lung mechanics and lung inflammation at 15, 30, 60 and 180 min after inoculation. TsV inoculation resulted in increased lung elastance when compared with the control group (p < 0.001); these values were significantly higher at 60 min than at 15 and 180 min (p < 0.05). Resistive pressure (DeltaP1) values decreased significantly at 30, 60 and 180 min after TsV injection (p < 0.001). TsV inoculation resulted in increased lung inflammation, characterised by an increased density of mononuclear cells at 15, 30, 60 and 180 min after TsV injection when compared with the control group (p < 0.001). TsV inoculation also resulted in an increased pulmonary density of polymorphonuclear cells at 15, 30 and 60 min following injection when compared to the control group (p < 0.001). In conclusion, T. serrulatus venom leads to acute lung injury, characterised by altered lung mechanics and increased pulmonary inflammation.
Paneque Peres
Ana Claudia
AC
Laboratory of Physiology and Pharmacodynamics, Research and Development Institute, University of Vale do Paraiba - UNIVAP, Sao Jose dos Campos, SP, Brazil.
Nonaka
Paula Naomi
PN
de Carvalho
Paulo de Tarso Camillo
Pde T
Toyama
Marcos Hikari
MH
Silva
Cesar Augusto Melo e
CA
Vieira
Rodolfo de Paula
RP
Dolhnikoff
Marisa
M
Zamuner
Stella Regina
SR
de Oliveira
Luis Vicente Franco
LV
D000818:Animals; D001696:Biomechanical Phenomena; D004548:Elasticity; D007202:Indicators and Reagents; D007273:Injections, Intramuscular; D007928:Lethal Dose 50; D008168:Lung / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051379:Mice; D020556:Neutrophil Infiltration / Q000187:drug effects; D011014:Pneumonia / Q000139:chemically induced* / Q000473:pathology*; D015656:Respiratory Mechanics / Q000187:drug effects*; D012604:Scorpion Venoms / Q000008:administration & dosage / Q000633:toxicity*
D007202:Indicators and Reagents; D012604:Scorpion Venoms