Skin-type adnexal tumor with trichoblastic germinative differentiation in the breast: a case report.
Adnexal tumors with follicular differentiation in the breast parenchyma are rarely encountered. The authors present a unique case arising in a 64-year-old woman, in whom they observed composite differentiation toward follicular germinative cells of the hair follicle with focal areas of outer root sheath differentiation and pilar-type keratinization. The histogenesis of this tumor is analyzed in light of the peculiar pathological, immunohistochemical, and molecular genetic findings.
Gököz
Ozay
O
Department of Pathology, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey.
Presenti
Loretta
L
Gambacorta
Giuseppina
G
Zolfanelli
Federica
F
Tricarico
Rossella
R
Nistri
Roberto
R
Baroni
Gianna
G
Bianchi
Simonetta
S
Massi
Daniela
D
D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D005260:Female; D006201:Hair Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D018859:Hair Follicle / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D020125:Mutation, Missense; D018294:Neoplasms, Adnexal and Skin Appendage / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D051176:beta Catenin / Q000235:genetics
D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D051176:beta Catenin