title: Irritable bowel syndrome is more frequent in patients hospitalized for ischaemic colitis: results of a case-control study.
abstract: It has been suspected that there is an epidemiological link between irritable bowel syndrome (IBS) and ischaemic colitis (IC). We performed a retrospective case-control study to compare the frequency of IBS in patients hospitalized for IC compared with that of patients with peptic ulcer bleeding. Cases were patients with a first episode of IC and controls were patients with a first episode of peptic ulcer bleeding, matched to cases for sex and 10-year age-class. Diagnosis of IBS was based on medical information extracted from hospital medical files and a standard self-questionnaire. The association between IBS and IC was tested using Mc Nemar's paired odds ratio (OR); confidence interval at 95% (CI 95%) was calculated; Mantel-Haenzel's Chi(2) was applied. A total of 113 cases and 113 matched controls were studied. There were 37 males and 76 females and the mean age was 69 +/- 15 years in each group. The prevalence of IBS in cases was 16.9%vs 1.8% in controls. The risk of IBS was 11.05 times higher among cases than in controls (P < 0.001); CI 95%: (2.45-49.74). A total of 87 pairs with complete data were used for OR calculation. The risk of IBS was 7.5 times higher in cases than in controls (P = 0.002); CI 95%: (1.72-32.80). This case-control study shows that IBS is more frequent in IC patients than in controls.
authors.affiliation: Département d'hépatogastroentérologie, Rouen University Hospital, Rouen, France. sophie.herve@chu-rouen.fr
authors.forename: S
authors.initials: S
authors.lastname: Hervé
authors.forename: L
authors.initials: L
authors.lastname: Beaugerie
authors.forename: Y
authors.initials: Y
authors.lastname: Bouhnik
authors.forename: G
authors.initials: G
authors.lastname: Savoye
authors.forename: J-F
authors.initials: JF
authors.lastname: Colombel
authors.forename: F
authors.initials: F
authors.lastname: Dyard
authors.forename: I
authors.initials: I
authors.lastname: Hourmand-Ollivier
authors.forename: T
authors.initials: T
authors.lastname: Dao
authors.forename: M
authors.initials: M
authors.lastname: Vial
authors.forename: E
authors.initials: E
authors.lastname: Lerebours
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D017091:Colitis, Ischemic / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D011795:Surveys and Questionnaires