Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis.
BACKGROUND
Psoriasis is a chronic inflammatory skin disease. Among other cytokines, interleukin 22 (IL-22) has been implicated in the pathogenesis of chronic plaque psoriasis. The purpose of this study was to investigate a hypothesized association between common IL-22 gene polymorphisms and chronic plaque psoriasis.


METHODS
Genotypes of 10 common polymorphisms of the IL-22 gene were determined by fluorogenic 5' exonuclease assays (TaqMan) in 475 patients with chronic plaque psoriasis and 252 controls.


RESULTS
Two blocks of high linkage disequilibrium, formed by eight polymorphisms upstream of exon 5 (rs2227485, rs2227491, rs2046068, rs1179251, rs1012356, rs2227501, rs2227503, rs976748) and two polymorphisms in the 3' near gene region (rs1182844, rs1179246), were observed within the IL-22 gene. Neither single polymorphisms nor haplotypes were significantly associated with the presence or clinical features of chronic plaque psoriasis (P > 0.05).


CONCLUSIONS
Our data suggest that the investigated IL-22 gene polymorphisms are unlikely major risk factors for chronic plaque psoriasis.
Weger
Wolfgang
W
Hofer
Angelika
A
Wolf
Peter
P
El-Shabrawi
Yosuf
Y
Renner
Wilfried
W
Kerl
Helmut
H
Salmhofer
Wolfgang
W
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D055815:Young Adult; D000097043:Interleukin-22
D007378:Interleukins; D000097043:Interleukin-22