title: Clinical operational tolerance after solid organ transplantation.
abstract: Clinical operational tolerance (COT) is a clinical condition obtainable with difficulty after solid organ transplantation (SOT). It is characterized by perfectly normal graft function in the total absence of maintenance immunosuppression. Major benefits deriving from the onset of COT are the reduction of risk for immunosuppression-related side effects and the improved quality of life. Currently, COT can be safely achieved in stable liver transplant recipients; it remains a challenge after renal transplantation. Only 1 case of COT has been reported after lung transplantation; no cases have been described after other types of SOT. Overall, mechanisms of COT are unclear and strategies to induce COT cannot be applied on a regular base to a large cohort of SOT recipients. Due to the failure of molecularly based tolerogenic protocols, great hope relies in the adoption of cell-based strategies.
authors.affiliation: Transplant Unit, San Salvatore Hospital, University of L'Aquila, L'Aquila, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Di Cocco
authors.forename: L
authors.initials: L
authors.lastname: Bonanni
authors.forename: M
authors.initials: M
authors.lastname: D'Angelo
authors.forename: K
authors.initials: K
authors.lastname: Clemente
authors.forename: S
authors.initials: S
authors.lastname: Greco
authors.forename: V
authors.initials: V
authors.lastname: Rizza
authors.forename: C
authors.initials: C
authors.lastname: Mazzotta
authors.forename: C
authors.initials: C
authors.lastname: Scelzo
authors.forename: A
authors.initials: A
authors.lastname: Famulari
authors.forename: F
authors.initials: F
authors.lastname: Pisani
authors.forename: G
authors.initials: G
authors.lastname: Orlando
mesh_terms: D006801:Humans; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D016377:Organ Transplantation
chemical_list: D007166:Immunosuppressive Agents