C-kit-positive gastric metastasis of lobular carcinoma of the breast masquerading as gastrointestinal stromal tumor.
A 61-year-old woman with no significant past history underwent gastric biopsies demonstrating a strongly c-kit-positive epithelioid malignancy, initially thought to represent gastrointestinal stromal tumor (GIST). Subsequent clinical and immunohistochemical evaluation proved the neoplasm to represent metastatic lobular carcinoma. This case illustrates that although c-kit is highly specific and sensitive for GIST, its expression may occur in a variety of other neoplasms, some of which morphologically resemble GIST and may present in the gastrointestinal tract as metastases. Therefore, a review of other c-kit-positive lesions is also highlighted.
Vennapusa
Bharathi
B
Department of Pathology, University of New Mexico, Albuquerque, 87131, USA. bvennapusa@salud.unm.edu
Oman
Sarah A
SA
Parasher
Gulshan
G
Cerilli
Lisa A
LA
D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary*; D003937:Diagnosis, Differential; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary*
D019009:Proto-Oncogene Proteins c-kit