[Effect of Acorus tatarinowii schott on ultrastructure and permeability of blood-brain barrier].
OBJECTIVE
To explore the influence of Acorus tatarinowii schott on ultrastructure and permeability of BBB.


METHODS
The ultrastructure and permeability of BBB on rats with A. tatarinowii by electron microscope were observed. The even's blue (EB) and sodium phenytoin in brain was determined by UV and HPLC-MS.


RESULTS
After give A. tatarinowii, tight junctions of the endothelial cell opened in cotex, and the concentration of EB and sodium phenytoin in brain are significant increased.


CONCLUSIONS
A. tatarinowii can increase the permeability of BBB, and show its 'Kaiqiao' effect.
Hu
Yuan
Y
Department of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, Beijing 100853, China.
Yuan
Mo
M
Liu
Ping
P
Mu
Lihua
L
Wang
Hong
H
D029023:Acorus / Q000737:chemistry*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000166:cytology; D002478:Cells, Cultured; D002560:Cerebrovascular Circulation; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D042783:Endothelial Cells; D008297:Male; D046529:Microscopy, Electron, Transmission; D009474:Neurons / Q000000981:diagnostic imaging / Q000187:drug effects*; D010539:Permeability / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019108:Tight Junctions / Q000187:drug effects / Q000648:ultrastructure; D014463:Ultrasonography
D004365:Drugs, Chinese Herbal