Macrocyclic design strategies for small, stable parallel beta-sheet scaffolds.
Pairs of short peptide strands can be induced to adopt an antiparallel beta-sheet secondary structure in aqueous solution via a macrocyclic constraint, as illustrated by many natural and designed peptides. We show that an analogous strategy is successful for creation of small units of parallel beta-sheet secondary structure in aqueous solution. Cyclization in this case requires nonpeptide segments for N-to-N and C-to-C interstrand linkage. Surprisingly, we find that only one of these segments needs to be preorganized.
Freire
Felix
F
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
Gellman
Samuel H
SH
D000595:Amino Acid Sequence; D003500:Cyclization; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D017433:Protein Structure, Secondary
D010455:Peptides