Vector retargeting for cancer gene therapy.
Vector tropism is a research hot spot in cancer gene therapy, and targeted viral vectors play a key role in the enhancement of safety and efficiency in cancer gene therapy. Vector retargeting is one of the important strategies on viral vector targeting. This review mainly focused on the progresses of vector retargeting in cancer gene therapy, and summarized relevant pathways and strategies.
Wei
Wei
W
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China.
Xue
Jing-lun
JL
Tian
Ling
L
D001360:Avidin; D001710:Biotin; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics*; D016679:Genome, Viral; D006801:Humans; D008024:Ligands; D009369:Neoplasms / Q000628:therapy*; D011993:Recombinant Fusion Proteins; D018523:Tropism
D008024:Ligands; D011993:Recombinant Fusion Proteins; D001360:Avidin; D001710:Biotin