title: Assessment of sensitivity and specificity of first, second, and third generation EIA for the detection of antibodies to HIV-1 in oral fluid.
abstract: The performances of three blood-based immunoassays test kits were compared with regard to their ability to detect HIV-1 antibody in oral fluid. It was found that these three kits differ in their ability to detect HIV-1 antibody. Notably, a third generation EIA which has been shown to possess superior sensitivity for antibody detection in plasma appears to possess no sensitivity advantage for detecting HIV-1 antibody in oral fluid.
authors.affiliation: San Francisco Department of Public Health Laboratory, 101 Grove Street, San Francisco, CA 94102, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Louie
authors.forename: John
authors.initials: J
authors.lastname: Lei
authors.forename: Sally
authors.initials: S
authors.lastname: Liska
authors.forename: Teri
authors.initials: T
authors.lastname: Dowling
authors.forename: Mark W
authors.initials: MW
authors.lastname: Pandori
mesh_terms: D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology / Q000302:isolation & purification*; D015658:HIV Infections / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D011933:Reagent Kits, Diagnostic; D012463:Saliva / Q000276:immunology*; D012680:Sensitivity and Specificity
chemical_list: D000914:Antibodies, Viral; D011933:Reagent Kits, Diagnostic