Bis-neonicotinoid insecticides: Observed and predicted binding interactions with the nicotinic receptor.
The bis-pharmacophore approach applied to neonicotinoid insecticides reveals high binding affinity for heptamethylene bis-N(3),N(3')-imidacloprid fitting a nicotinic acetylcholine receptor model wherein the chloropyridine moieties contact loops E and F and the alkylene linker bridges these two distant domains.
Ohno
Ikuya
I
Department of Chemistry, Faculty of Education, Gifu University, Gifu 501-1193, Japan.
Tomizawa
Motohiro
M
Tomizawaa
Motohiro
M
Durkin
Kathleen A
KA
Casida
John E
JE
Kagabu
Shinzo
S
D000818:Animals; D001665:Binding Sites; D003198:Computer Simulation; D004330:Drosophila; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry*; D000073943:Neonicotinoids; D018733:Nicotinic Antagonists / Q000138:chemical synthesis / Q000737:chemistry*; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011485:Protein Binding; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000378:metabolism
D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D018733:Nicotinic Antagonists; D009574:Nitro Compounds; D011978:Receptors, Nicotinic; C082359:imidacloprid