title: Complex interactions in the regulation of trypanosome mitochondrial gene expression.
abstract: Trypanosomes undergo extreme physiological changes to adapt to different environments as they cycle between hosts. Adaptation to the different environments has evolved an energy metabolism involving a mitochondrion with an unusual genome. Recently, Aphasizhev and colleagues have identified two new protein complexes, a mitochondrial polyadenylation complex and a guide RNA stabilization complex, that provide novel insights into the coordinated expression of the mitochondrial genome.
authors.affiliation: Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Koslowsky
mesh_terms: D000818:Animals; D018105:DNA, Kinetoplast / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D050259:Genes, Mitochondrial; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism*; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000378:metabolism*
chemical_list: D018105:DNA, Kinetoplast; D015800:Protozoan Proteins