Spectrophotometric determination of triclosan in personal care products.
A spectrophotometric method for the determination of triclosan in personal care products was proposed. It was based on the reaction of sodium nitrite with p-sulfanilic acid in an acidic medium to form diazonium ion, with which triclosan further formed an azo compound in an alkaline medium. The resulting yellow colored product has a maximum absorption at 452 nm. A good linear relationship (r=0.9999) was obtained in the range of 0-30 mg L(-1) triclosan. A detection limit of 0.079 gL(-1) was achieved and the relative standard deviation was 0.24% (n=11) at 14 mg L(-1) triclosan. The proposed method has been applied to the analyses of triclosan in several personal care products and the results were in good agreement with those obtained by high-performance liquid chromatography.
Lu
Huihui
H
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China.
Ma
Hongbing
H
Tao
Guanhong
G
D000891:Anti-Infective Agents, Local / Q000032:analysis* / Q000737:chemistry; D003358:Cosmetics / Q000032:analysis*; D004202:Disinfectants / Q000032:analysis*; D016014:Linear Models; D012680:Sensitivity and Specificity; D012977:Sodium Nitrite / Q000737:chemistry; D013053:Spectrophotometry / Q000191:economics / Q000379:methods*; D013425:Sulfanilic Acids / Q000737:chemistry; D013997:Time Factors; D014100:Toothpastes / Q000032:analysis; D014260:Triclosan / Q000032:analysis* / Q000737:chemistry
D000891:Anti-Infective Agents, Local; D003358:Cosmetics; D004202:Disinfectants; D013425:Sulfanilic Acids; D014100:Toothpastes; D014260:Triclosan; D012977:Sodium Nitrite