A practical and efficient synthesis of bis(indolyl)methanes in water, and synthesis of di-, tri-, and tetra(bis-indolyl)methanes under thermal conditions catalyzed by oxalic acid dihydrate.
A simple, clean, and highly efficient green protocol has been developed for synthesis of bis(indolyl), di(bis-indolyl), and tris-indolyl methanes by the reaction of indole with aldehydes and ketones in the presence of oxalic acid dihydrate [(CO(2)H)(2).2H(2)O] and N-cetyl-N, N, N-trimethylammonium bromide (CTAB) in water. Also, tri(bis-indolyl) and tetra(bis-indolyl)methanes as new bis(indolyl)methanes were prepared under thermal conditions.
Ghorbani-Vaghei
Ramin
R
Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, 65174, Hamadan, Iran. rgvaghei@yahoo.com
Veisi
Hojat
H
Keypour
Hassan
H
Dehghani-Firouzabadi
Ahmad Ali
AA
D000447:Aldehydes / Q000737:chemistry; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D019815:Oxalic Acid / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D000447:Aldehydes; D002593:Cetrimonium Compounds; D007211:Indoles; D007659:Ketones; D014867:Water; D019815:Oxalic Acid; D008697:Methane; D000077286:Cetrimonium