title: [Helicobacter pylori in patients with disorders of hepatobiliary system].
abstract: OBJECTIVE
  Detection of H. pylori in gastric mucosa, bile-excreting ducts, livertissue, and bile of patients with different disorders hepatobiliary system (HBS).
  
  
  METHODS
  Seventy-six patients (52 females and 24 males) with following diagnoses: chronic noncalculous cholecystitis (25 patients), gallstone disease (28), liver cirrhosis (12), ischemic heart disease (control group, n = 11), admitted to hospitals in Kazan and Zelenodolsk (Republic of Tatarstan), were examined. Mean age of the patients was 56.5 years. Samples of bile as well as tissues of liver, bile ducts and gastric mucosa were used as materials for tests. Polymerase chain reaction and culture method were used for H. pylori detection.
  
  
  RESULTS
  Analysis of obtained results showed association of clinical diagnosis and presence of H. pylori DNA in bile ducts mucosal epithelium. H. pylori was significantly more frequently detected in epithelium of bile ducts mucosa (66.7 +/- 13.6%) and bile(56 +/- 9.9%) than in liver tissue (33.3 +/- 13.6%) (p < 0.05). Rate of H. pylori detection in gastric mucosa (83.3 +/- 10.8% in patients with liver cirrhosis) correlated with its detection rate in bile ducts mucosa (66.7 +/- 13.6%). In the control group of 11 patients with ischemic heart disease H. pylori was not detected. In 16 samples of liver, bile ducts, and gastric tissues CagA-negative phenotype was observed.
  
  
  CONCLUSIONS
  Presence of H. pylori in liver, bile ducts and bile could point to possible role of its microorganism in pathogenesis of hepatobiliary diseases.
authors.forename: G Sh
authors.initials: GSh
authors.lastname: Isaeva
authors.forename: E R
authors.initials: ER
authors.lastname: Abuzarova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Valeeva
authors.forename: O K
authors.initials: OK
authors.lastname: Pozdeev
authors.forename: E V
authors.initials: EV
authors.lastname: Murav'eva
mesh_terms: D042101:Acalculous Cholecystitis / Q000382:microbiology*; D000942:Antigens, Bacterial / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D001646:Bile / Q000382:microbiology; D001652:Bile Ducts / Q000382:microbiology; D002769:Cholelithiasis / Q000382:microbiology*; D002908:Chronic Disease; D015169:Colony Count, Microbial; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008099:Liver / Q000382:microbiology; D008103:Liver Cirrhosis / Q000382:microbiology*; D008297:Male; D008875:Middle Aged
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C080866:cagA protein, Helicobacter pylori