[VEGF, COX-2 and MVD in lesions of patients with condyloma acuminatum].
OBJECTIVE
To determine the roles of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in the occurrence and development of condyloma acuminatum (CA).


METHODS
The VEGF, COX-2, and microvascular density (MVD) in the lesions of 61 CA patients were detected with immunohistochemical SP method. Seventeen skin tissues from healthy men served as controls.


RESULTS
The CA patients had greater positive rate and field-strength scores of VEGF and COX-2 than the controls (P < 0.05). VEGF positively correlated with COX-2 in the CA lesions (r = 0.749, P < 0.05). With the increase of number and diameters of CA lesions, the field-strength scores of VEGF and COX-2 increased (P < 0.05). The positive rates and field-strength scores did not change with the courses of the CA disease (P > 0.05). The CA lesions also had greater MVD than the controls (P < 0.05). The CA lesions with positive VEGF and COX-2 had greater MVD than those with negative VEGF and COX-2 (P < 0.05). Both VEGF and COX-2 were positively correlated with MVD (r = 0.348 and 0.327 respectively, P < 0.05).


CONCLUSIONS
VEGF and COX-2 promote the abnormal angiogenesis and the cell proliferation in CA lesions, which accelerate the progress of wart lesions. The two factors have synergistic
Liu
Tong
T
Department of Dermatology, the First Affiliated Hospital, Medical School of Xi 'an Jiaotong University, Xi' an 710061, China.
Zhang
Hong-hui
HH
D000293:Adolescent; D000328:Adult; D002196:Capillaries / Q000473:pathology; D003218:Condylomata Acuminata / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D012867:Skin / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human