Experimental evaluation of a new antithrombogenic stent using ion beam surface modification.
A new antithrombogenic stent using ion beam surface modification nanotechnology was evaluated. The ion stent is being developed to inhibit acute and chronic stent-related thrombosis. Thirty self-expanding mesh stents were fabricated from Ti-Ni metal wires with a dimension of 4 mm (diameter) x 25 mm (length) x 0.15 mm (thickness). Twenty stents were coated with type I collagen and irradiated with a He(+) ion beam at an energy of 150 keV with fluences of 1 x 10(14) ions/cm(2) (ion stent group). Ten stents had no treatment (non-ion stent group). The self-expanding stents were implanted into the right and left peripheral femoral arteries of 15 beagle dogs (vessel diameter approximately 3 mm) via a 6Fr catheter under fluoroscopic guidance. Heparin (100 units/kg) was administered intravenously before implantation. Following stent implantation, no antiplatelet or anticoagulant drugs were administered. The 1-month patency rate for the non-ion stent group was 10% (1/10), and for the ion stent group it was 80% (16/20) with no anticoagulant or antiplatelet drugs given after stent implantation (P = 0.0004 by Fisher's exact test). Ten stents remain patent after 2 years in vivo with no anticoagulant or antiplatelet drugs. These results indicate that He(+) ion-implanted collagen-coated Ti-Ni self-expanding stents have excellent antithrombogenicity and biocompatibility. This ion stent is promising for coronary and cerebral stent applications.
Sugita
Yoichi
Y
Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. sugita@bcm.edu
Suzuki
Yoshiaki
Y
Someya
Kenji
K
Ogawa
Akira
A
Furuhata
Hiroshi
H
Miyoshi
Shinichiro
S
Motomura
Tadashi
T
Miyamoto
Hiroshi
H
Igo
Stephen
S
Nosé
Yukihiko
Y
D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects*; D019917:Blood Vessel Prosthesis Implantation; D002414:Cations, Monovalent / Q000737:chemistry / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D024042:Collagen Type I / Q000737:chemistry / Q000494:pharmacology*; D004285:Dogs; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects*; D006371:Helium / Q000737:chemistry / Q000494:pharmacology*; D008422:Materials Testing; D009532:Nickel / Q000737:chemistry; D015607:Stents / Q000009:adverse effects; D013927:Thrombosis / Q000209:etiology / Q000628:therapy; D013997:Time Factors; D014025:Titanium / Q000737:chemistry
D002414:Cations, Monovalent; D020099:Coated Materials, Biocompatible; D024042:Collagen Type I; C040654:titanium nickelide; D006371:Helium; D009532:Nickel; D014025:Titanium