The unique characteristics of ovarian carcinogenesis in the adolescent and young adult population.
Ovarian cancer in the adolescent and young adult (AYA) population is a disease that is distinctly different with regard to risk factors, genetics, and pathology when compared to ovarian cancers occurring in older women. This article will review the theories behind ovarian carcinogenesis and attempt to elucidate why these tumors exhibit their unique biologic characteristics. Knowledge of these differences will allow us to begin to develop strategies for future research endeavors enabling improved survival in AYA women diagnosed with ovarian cancer.
Gibbon
Darlene G
DG
Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, The Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA. gibbonda@umdnj.edu
Diaz-Arrastia
Concepcion
C
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003276:Contraceptives, Oral / Q000627:therapeutic use; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D009373:Neoplasms, Germ Cell and Embryonal / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy; D012307:Risk Factors
D003276:Contraceptives, Oral