Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro.
Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.
Wang
Gui-Feng
GF
Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China.
Shi
Li-Ping
LP
Ren
Yu-Dan
YD
Liu
Qun-Fang
QF
Liu
Hou-Fu
HF
Zhang
Ru-Jun
RJ
Li
Zhuang
Z
Zhu
Feng-Hua
FH
He
Pei-Lan
PL
Tang
Wei
W
Tao
Pei-Zhen
PZ
Li
Chuan
C
Zhao
Wei-Min
WM
Zuo
Jian-Ping
JP
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002109:Caffeic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D002726:Chlorogenic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D004372:Ducks; D018347:Hepadnaviridae Infections / Q000188:drug therapy*; D015611:Hepatitis B Virus, Duck / Q000187:drug effects*; D006524:Hepatitis, Viral, Animal / Q000188:drug therapy*; D022781:Hepatocytes / Q000821:virology; D006801:Humans; D020128:Inhibitory Concentration 50; D011801:Quinic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D044967:Serum / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D002109:Caffeic Acids; D011801:Quinic Acid; D002726:Chlorogenic Acid; C040048:caffeic acid