title: Synthesis, characterization, antimicrobial and antitumor screening of some diorganotin(IV) complexes of 2-[(9H-Purin-6-ylimino)]-phenol.
abstract: A new series of diorganotin(IV) complexes of the type R(2)SnL(2) (R=Me, Et, Bu, Ph, Bz and L=2-[(9H-Purin-6-ylimino)]-phenol) have been synthesized, characterized by elemental analyses and their solid state configuration has been determined by various spectroscopic (IR, (1)H, (13)C, (119)Sn NMR, (119m)Sn Mössbauer) techniques. The results obtained on the basis of these techniques are in full concurrence with the proposed 2:1 stoichiometry. The title complexes have been screened against various microorganisms, fungi and human cell line KB, the results obtained showed that the bis(2-[(9H-Purin-6-ylimino)]-phenolate) diphenyltin(IV) complex exhibited excellent activity against all types of bacteria and fungi used, while bis(2-[(9H-Purin-6-ylimino)]-phenolate) diethyltin(IV) complex was found to have promising antitumor activity.
authors.affiliation: Department of Chemistry, Hazara University, Mansehra, Pakistan. sono_waj@yahoo.com
authors.forename: Wajid
authors.initials: W
authors.lastname: Rehman
authors.forename: Amin
authors.initials: A
authors.lastname: Badshah
authors.forename: Salimullah
authors.initials: S
authors.lastname: Khan
authors.forename: Le Thi Anh
authors.initials: le TA
authors.lastname: Tuyet
mesh_terms: D000225:Adenine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019800:Phenol / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D015204:Spectroscopy, Mossbauer
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D009947:Organotin Compounds; D019800:Phenol; D000225:Adenine