Colonization and subsequent skin and soft tissue infection due to methicillin-resistant Staphylococcus aureus in a cohort of otherwise healthy adults infected with HIV type 1.
Methicillin-resistant Staphylococcus aureus (MRSA) carriage and subsequent infection were prospectively compared among a well-defined group of 107 individuals infected with human immunodeficiency virus type 1 (HIV-1) who had no evidence of immune suppression and 52 epidemiologically matched, uninfected individuals. The carriage strains and infecting strains were genetically characterized. The cumulative prevalence of MRSA carriage was significantly higher among HIV-infected individuals (16.8%) than among individuals without HIV infection (5.8%) (P = .04; odds ratio, 3.3 [95% confidence interval, 1.3-14.7]). Fifteen of 21 MRSA isolates recovered from colonized individuals were identified as strain USA300. Of the 10 MRSA skin and soft tissue infections observed in this study, all occurred in HIV-infected individuals who were colonized with the same strain that caused the infection. Previous antibiotic use was the only statistically significant risk factor for MRSA carriage. These data highlight the fact that MRSA colonization and infection are important clinical issues among asymptomatic HIV-1-infected individuals.
Shet
Anita
A
Aaron Diamond AIDS Research Center, New York, New York, USA.
Mathema
Barun
B
Mediavilla
Jose R
JR
Kishii
Kozue
K
Mehandru
Saurabh
S
Jeane-Pierre
Patrick
P
Laroche
Mathew
M
Willey
Barbara M
BM
Kreiswirth
Nathan
N
Markowitz
Martin
M
Kreiswirth
Barry N
BN
D000328:Adult; D015658:HIV Infections / Q000150:complications* / Q000382:microbiology; D015497:HIV-1; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus; D009519:New York City; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000635:transmission; D013207:Staphylococcal Skin Infections / Q000188:drug therapy / Q000453:epidemiology; D019562:Viral Load