title: Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population.
abstract: Excessive immune response is believed to play a role in the development of severe acute respiratory syndrome (SARS). Inhomogeneous spread of SARS led one to think of an Asian genetic predisposition and contribution of human leukocyte antigen (HLA) to the disease susceptibility. However, past case-control studies showed inconsistent results. In Viet Nam, of 62 patients with SARS, 44 participated in the present study together with 103 individuals who had contact with SARS patients and 50 without contact history. HLA-DRB1*12 was more frequently shown in SARS patients than in controls (corrected p = 0.042). HLA-DRB1*1202, the predominant allele in the Vietnamese population showed the strongest association with SARS in a dominant model (corrected p = 0.0065 and 0.0052, depending on the controls to be compared). Our results and accumulated data on HLA in the Asian populations would help in the understanding of associations with emerging infectious diseases.
authors.affiliation: Department of Respiratory Diseases, Research Institute, Tokyo, Japan. nkeicho-tky@umin.ac.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Keicho
authors.forename: Satoru
authors.initials: S
authors.lastname: Itoyama
authors.forename: Koichi
authors.initials: K
authors.lastname: Kashiwase
authors.forename: Nguyen Chi
authors.initials: NC
authors.lastname: Phi
authors.forename: Hoang Thuy
authors.initials: HT
authors.lastname: Long
authors.forename: Le Dang
authors.initials: LD
authors.lastname: Ha
authors.forename: Vo Van
authors.initials: VV
authors.lastname: Ban
authors.forename: Bach Khanh
authors.initials: BK
authors.lastname: Hoa
authors.forename: Nguyen Thi Le
authors.initials: NT
authors.lastname: Hang
authors.forename: Minako
authors.initials: M
authors.lastname: Hijikata
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Sakurada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Satake
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Takehiko
authors.initials: T
authors.lastname: Sasazuki
authors.forename: Tran
authors.initials: T
authors.lastname: Quy
mesh_terms: D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D011110:Polymorphism, Genetic; D045169:Severe Acute Respiratory Syndrome / Q000208:ethnology / Q000235:genetics*; D014744:Vietnam
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553514:HLA-DRB1*12:02 antigen