title: Serum concentration of lidocaine after transversus abdominis plane block.
abstract: We measured the serum concentration of lidocaine after transversus abdominis plane (TAP) block with 40 ml of 1% lidocaine in 12 patients under general anesthesia, using a fluorescence polarization immunoassay. The peak mean serum concentration of lidocaine occurred 30 min after the block (3.6 +/- 0.7 microg x ml(-1)). The highest concentration of lidocaine (5.microg x ml(-1)) was recorded 15 min after the block. These results indicate that a TAP block can potentially cause systemic toxicity of a local anesthetic. The analgesic effect of the TAP block may partially depend on the rise in serum concentration of the local anesthetic.
authors.affiliation: Department of Anesthesiology, Aichi Gakuin University School of Dentistry, Aichi, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kato
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Misako
authors.initials: M
authors.lastname: Harato
authors.forename: Shuji
authors.initials: S
authors.lastname: Kurokawa
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shibata
authors.forename: Jun
authors.initials: J
authors.lastname: Harada
authors.forename: Toru
authors.initials: T
authors.lastname: Komatsu
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D016231:Fluorescence Polarization Immunoassay; D013509:Gynecologic Surgical Procedures; D006801:Humans; D008012:Lidocaine / Q000097:blood* / Q000627:therapeutic use; D008875:Middle Aged; D009407:Nerve Block; D010149:Postoperative Pain / Q000188:drug therapy
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine