title: Gamma-lactone carbazoles from Clausena anisata.
abstract: The study of chemical constituents of the stems of Clausena anisata collected in Thailand led to the isolation and identification of eight known and two new carbazole alkaloids named furanoclausamines A (1) and B (2). Clausamine E (3) was found to exhibit cytotoxicity against the human leukemia cell line HL-60.
authors.affiliation: Faculty of Pharmacy, Meijo University, Tempaku, Nagoya, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
authors.forename: Kie
authors.initials: K
authors.lastname: Aizawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yoshida
authors.forename: Nijsiri
authors.initials: N
authors.lastname: Ruangrungsi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000470:Alkaloids / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D054700:Clausena / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013785:Thailand
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002227:Carbazoles; D007783:Lactones; C542218:clausamine E; C542217:furanoclausamine A; C542219:furanoclausamine B