title: Structural correlates of functional language dominance: a voxel-based morphometry study.
abstract: OBJECTIVE
  The goal of this study was to explore the structural correlates of functional language dominance by directly comparing the brain morphology of healthy subjects with left- and right-hemisphere language dominance.
  
  
  METHODS
  Twenty participants were selected based on their language dominance from a cohort of subjects with known language lateralization. Structural differences between both groups were assessed by voxel-based morphometry, a technique that automatically identifies differences in the local gray matter volume between groups using high-resolution T1-weighted magnetic resonance images.
  
  
  RESULTS
  The main findings can be summarized as follows: (1) Subjects with right-hemisphere language dominance had significantly larger gray matter volume in the right hippocampus than subjects with left-hemisphere language dominance. (2) Leftward structural asymmetries in the posterior superior temporal cortex, including the planum temporale (PT), were observed in both groups.
  
  
  CONCLUSIONS
  Our study does not support the still prevalent view that asymmetries of the PT are related in a direct way to functional language lateralization. The structural differences found in the hippocampus underline the importance of the medial temporal lobe in the neural language network. They are discussed in the context of recent findings attributing a critical role of the hippocampus in the development of language lateralization.
authors.affiliation: Department of Neurology, University of Münster, Münster, Germany (AJ, GL, MD, CO, JMA, SK); Department of Neurology II, University of Magdeburg, Magdeburg, Germany (MK); Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts (GS); IZKF Münster, University of Münster, Münster, Germany (SK); Section of Neuroimaging, Department of Psychiatry und Psychotherapy, Philipps University Marburg, Marburg, Germany (AJ).
authors.forename: Andreas
authors.initials: A
authors.lastname: Jansen
authors.affiliation: Department of Neurology, University of Münster, Münster, Germany (AJ, GL, MD, CO, JMA, SK); Department of Neurology II, University of Magdeburg, Magdeburg, Germany (MK); Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts (GS); IZKF Münster, University of Münster, Münster, Germany (SK); Section of Neuroimaging, Department of Psychiatry und Psychotherapy, Philipps University Marburg, Marburg, Germany (AJ).
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Liuzzi
authors.affiliation: Department of Neurology, University of Münster, Münster, Germany (AJ, GL, MD, CO, JMA, SK); Department of Neurology II, University of Magdeburg, Magdeburg, Germany (MK); Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts (GS); IZKF Münster, University of Münster, Münster, Germany (SK); Section of Neuroimaging, Department of Psychiatry und Psychotherapy, Philipps University Marburg, Marburg, Germany (AJ).
authors.forename: Michael
authors.initials: M
authors.lastname: Deppe
authors.affiliation: Department of Neurology, University of Münster, Münster, Germany (AJ, GL, MD, CO, JMA, SK); Department of Neurology II, University of Magdeburg, Magdeburg, Germany (MK); Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts (GS); IZKF Münster, University of Münster, Münster, Germany (SK); Section of Neuroimaging, Department of Psychiatry und Psychotherapy, Philipps University Marburg, Marburg, Germany (AJ).
authors.forename: Martin
authors.initials: M
authors.lastname: Kanowski
authors.affiliation: Department of Neurology, University of Münster, Münster, Germany (AJ, GL, MD, CO, JMA, SK); Department of Neurology II, University of Magdeburg, Magdeburg, Germany (MK); Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts (GS); IZKF Münster, University of Münster, Münster, Germany (SK); Section of Neuroimaging, Department of Psychiatry und Psychotherapy, Philipps University Marburg, Marburg, Germany (AJ).
authors.forename: Christian
authors.initials: C
authors.lastname: Ölschläger
authors.affiliation: Department of Neurology, University of Münster, Münster, Germany (AJ, GL, MD, CO, JMA, SK); Department of Neurology II, University of Magdeburg, Magdeburg, Germany (MK); Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts (GS); IZKF Münster, University of Münster, Münster, Germany (SK); Section of Neuroimaging, Department of Psychiatry und Psychotherapy, Philipps University Marburg, Marburg, Germany (AJ).
authors.forename: Johannes M
authors.initials: JM
authors.lastname: Albers
authors.affiliation: Department of Neurology, University of Münster, Münster, Germany (AJ, GL, MD, CO, JMA, SK); Department of Neurology II, University of Magdeburg, Magdeburg, Germany (MK); Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts (GS); IZKF Münster, University of Münster, Münster, Germany (SK); Section of Neuroimaging, Department of Psychiatry und Psychotherapy, Philipps University Marburg, Marburg, Germany (AJ).
authors.forename: Gottfried
authors.initials: G
authors.lastname: Schlaug
authors.affiliation: Department of Neurology, University of Münster, Münster, Germany (AJ, GL, MD, CO, JMA, SK); Department of Neurology II, University of Magdeburg, Magdeburg, Germany (MK); Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts (GS); IZKF Münster, University of Münster, Münster, Germany (SK); Section of Neuroimaging, Department of Psychiatry und Psychotherapy, Philipps University Marburg, Marburg, Germany (AJ).
authors.forename: Stefan
authors.initials: S
authors.lastname: Knecht
mesh_terms: D000328:Adult; D001921:Brain / Q000166:cytology* / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic