A new biodegradable crosslinked polyethylene oxide sulfide (PEOS) hydrogel for controlled drug release.
We developed a polyethylene glycol (PEG)-based biodegradable hydrogel through disulfide crosslinking of polyethylene oxide sulfide (PEOS). The crosslinking rate was highly dependent on temperature, and incubation at about 40-50 degrees C was required for efficient crosslinking. The crosslinked PEOS hydrogel showed glutathione-dependent dissolution and corresponding controlled release of a model drug-fluorescein isothiocyanate (FITC)-labeled dextran-because the disulfide bond, the main linker, is selectively degraded in response to the high concentration of glutathione. The temperature-sensitive crosslinking and the hydrogel formation have the potential for use as an injectable biogel precursor, which was confirmed by in situ gel formation in mice.
Koo
Heebeom
H
School of Chemistry & Molecular Engineering, Seoul National University, Shillim-dong, Kwanak-ku, Seoul, Republic of Korea.
Jin
Geun-Woo
GW
Kang
Hyunseo
H
Lee
Yan
Y
Nam
Hye Yeong
HY
Jang
Hyung-suk
HS
Park
Jong-Sang
JS
D000818:Animals; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations; D003911:Dextrans / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry; D016650:Fluorescein-5-isothiocyanate / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005978:Glutathione / Q000378:metabolism; D020100:Hydrogels; D007279:Injections, Subcutaneous; D051379:Mice; D008810:Mice, Inbred C57BL; D011092:Polyethylene Glycols / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*; D013696:Temperature
D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D003911:Dextrans; D004337:Drug Carriers; D020100:Hydrogels; D013440:Sulfides; C015219:fluorescein isothiocyanate dextran; D011092:Polyethylene Glycols; D005978:Glutathione; D016650:Fluorescein-5-isothiocyanate