Morphological evaluation of Schnyder's crystalline corneal dystrophy by laser scanning confocal microscopy and Fourier-domain optical coherence tomography.
A 29-year-old Chinese woman with Schnyder's crystalline corneal dystrophy was referred to our clinic. Ocular examination revealed abnormal deposits of cholesterol and lipid within the corneal stroma, appearing as crystalline needle-shaped deposits, in both eyes. In vivo laser scanning confocal microscopy revealed pathological alterations of the normal corneal anatomy in the patient, such as highly reflective crystalline structures in the anterior-and mid-stroma. The images acquired from Fourier-domain optical coherence tomography indicated that the main presence of crystalline deposits was localized within the anterior stroma, extending from the basal epithelium layer to a depth of 80 to 150 microm. To the best of the author's knowledge, it is consistent with the results of the previous histological study.
Jing
Yang
Y
Department of Ophthalmology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Wang
Liya
L
D000328:Adult; D002784:Cholesterol / Q000097:blood; D003315:Cornea / Q000473:pathology; D003317:Corneal Dystrophies, Hereditary / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging; D018613:Microscopy, Confocal; D020795:Photophobia; D011859:Radiography; D041623:Tomography, Optical Coherence; D015354:Vision, Low; D014792:Visual Acuity
D002784:Cholesterol