The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis.
BACKGROUND
Several experimental studies have been carried out to explain the physiopathological mechanisms and to introduce endocrinological, enzymatic, biochemical and histopathological changes in organisms during acute pancreatitis.


OBJECTIVE
To evaluate the effect of an intraperitoneal injection of melatonin on serum amylase levels.


METHODS
Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats. The rats were then divided into two groups: control and melatonin groups.


METHODS
The serum amylase level was measured on the 7th day after acute pancreatitis had developed. In the melatonin group, an intraperitoneal injection of melatonin (20 mg/kg/day) was performed starting from the 2(nd) day after pancreatic duct ligation.


METHODS
The levels of serum amylase were measured with an auto analyzer.


RESULTS
It was found that the mean (+/-SD) level of serum amylase in the control group was 947+/-182 IU/mL while it was 358+/-177 IU/mL in the experimental group (P<0.001).


CONCLUSIONS
The 20 mg/kg/day intraperitoneal injection of melatonin which was carried out for one week attenuated the serum amylase levels to a statistically significant degree. The researchers believe that intraperitoneal injections of melatonin decrease the severity of acute pancreatitis.
Cöl
Cavit
C
Department of General Surgery, Medical Faculty of Abant Izzet Baysal University, Bolu, Turkey. cavitcol@yahoo.com
Dinler
Kahraman
K
Hasdemir
Ahmet Oguz
AO
Bugdayci
Guler
G
D000208:Acute Disease; D000681:Amylases / Q000097:blood*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008026:Ligation; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010183:Pancreatic Ducts; D010195:Pancreatitis / Q000188:drug therapy* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D000681:Amylases; D008550:Melatonin