title: Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro.
abstract: Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.
authors.affiliation: Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China.
authors.forename: Gui-Feng
authors.initials: GF
authors.lastname: Wang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Shi
authors.forename: Yu-Dan
authors.initials: YD
authors.lastname: Ren
authors.forename: Qun-Fang
authors.initials: QF
authors.lastname: Liu
authors.forename: Hou-Fu
authors.initials: HF
authors.lastname: Liu
authors.forename: Ru-Jun
authors.initials: RJ
authors.lastname: Zhang
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Li
authors.forename: Feng-Hua
authors.initials: FH
authors.lastname: Zhu
authors.forename: Pei-Lan
authors.initials: PL
authors.lastname: He
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Pei-Zhen
authors.initials: PZ
authors.lastname: Tao
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Zhao
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zuo
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002109:Caffeic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D002726:Chlorogenic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D004372:Ducks; D018347:Hepadnaviridae Infections / Q000188:drug therapy*; D015611:Hepatitis B Virus, Duck / Q000187:drug effects*; D006524:Hepatitis, Viral, Animal / Q000188:drug therapy*; D022781:Hepatocytes / Q000821:virology; D006801:Humans; D020128:Inhibitory Concentration 50; D011801:Quinic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D044967:Serum / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D002109:Caffeic Acids; D011801:Quinic Acid; D002726:Chlorogenic Acid; C040048:caffeic acid