title: Overexpression of CD123 correlates with the hyperdiploid genotype in acute lymphoblastic leukemia.
abstract: We evaluated CD123 expression in 95 pediatric and 24 adult ALL patients and compared the results with the CD123 expression in normal B-cell precursors. Early B-cell precursors were negative while intermediate precursors and mature B cells showed weak CD123 expression. Leukemic blasts in 31% of precursor-B ALL samples exhibited strong expression of CD123, 61% had moderate CD123 expression and 8% were negative; 81.5% of ALL with hyperdiploid karyotype (>/= 52 chromosomes) showed strong CD123 overexpression. In contrast, cases with ETV6/RUNX1 rearrangement had weak CD123 expression. Our study suggests that overexpression of CD123 is an aberrant phenotype present in a subset of precursor-B ALL with hyperdiploid genotype, and represents an additional marker of good prognosis in pediatric precursor-B ALL. Moreover, aberrant CD123 expression in ALL is a good marker for monitoring of minimal residual disease.
authors.affiliation: 1Department of Pathology, Karolinska University Hospital, Stockholm, Sweden. djokicm@upmc.edu
authors.forename: Miroslav
authors.initials: M
authors.lastname: Djokic
authors.forename: Elisabet
authors.initials: E
authors.lastname: Björklund
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Blennow
authors.forename: Joanna
authors.initials: J
authors.lastname: Mazur
authors.forename: Stefan
authors.initials: S
authors.lastname: Söderhäll
authors.forename: Anna
authors.initials: A
authors.lastname: Porwit
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004171:Diploidy; D015973:Gene Expression Regulation, Leukemic; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053650:Interleukin-3 Receptor alpha Subunit / Q000096:biosynthesis* / Q000235:genetics*; D007621:Karyotyping; D008875:Middle Aged; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000378:metabolism*
chemical_list: D053650:Interleukin-3 Receptor alpha Subunit