Watching moving images specifically promotes development of medial area of secondary visual cortex in rat.
It is generally accepted that the cortex can be divided into numerous regions depending on the type of information each processes, and that specific input is effective in improving the development of related regions. In visual cortex, many subareas are distinguished on the basis of their adequate information. However, whether the development of a subarea can be specifically improved by its particular input is still largely unknown. Here, we show the specific effects of motion information on the development of the medial area of secondary visual cortex (V2M), a subarea associated with processing the movement component of visual information. Although watching a moving or a still image had similar effects in primary visual cortex, the moving image induced multistage development of V2M in dark-reared rats: both mRNA and protein levels of GluR2 were upregulated, the density and protein content of GluR2-positive synapses increased, and the spine density and the frequency of spontaneous excitatory postsynaptic currents (EPSCs) of pyramidal neurons in Layer 5 were elevated. Our results suggest that rats are able to identify motion information, distribute it to V2M, and then use this input to specifically improve the development of V2M.
Sun
Baonan
B
State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China.
Lv
Bing
B
Dong
Qiping
Q
Wang
Shiqiang
S
Chai
Zhen
Z
D000818:Animals; D000831:Animals, Newborn; D001931:Brain Mapping; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D066298:In Vitro Techniques; D018613:Microscopy, Confocal; D009039:Motion Perception / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000235:genetics / Q000378:metabolism; D011984:Sensory Receptor Cells / Q000502:physiology / Q000648:ultrastructure; D016622:Silver Staining; D014793:Visual Cortex / Q000033:anatomy & histology* / Q000254:growth & development* / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology
D018091:Receptors, AMPA; C104722:glutamate receptor ionotropic, AMPA 2