Conjugates of boron clusters with derivatives of natural chlorin and bacteriochlorin.
Conjugates of bacteriochlorin p and chlorin e(6) with cobalt bis(dicarbollide) anion [3,3'-Co(1,2-C(2)B(9)H(11))(2)](-) were synthesized using different synthetic approaches. The boronated bacteriochlorin p was prepared by reaction of bacteriochlorin N-amino cycloimide with, bis(dicarbollide)-based carboxylic acid. The boronated chlorin e(6) conjugates were obtained by both "click reaction" of containing alkyne group chlorine with azide derivative of cobaltacarborane and reaction of chorin-based amines with cyclic oxonium derivative of cobalt bis(dicarbollide).
Bregadze
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VI
A.N. Nesmeyanov Institute of Organoelement Compounds (INEOS), Russian Academy of Sciences, 28 Vavilov Str., 119991 Moscow, Russia. bre@ineos.ac.ru
Sivaev
I B
IB
Lobanova
I A
IA
Titeev
R A
RA
Brittal
D I
DI
Grin
M A
MA
Mironov
A F
AF
D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D010778:Photochemotherapy; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry*
D001896:Boron Compounds; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C452433:bacteriochlorin; C006969:chlorin