[Mucoid impaction of the bronchi caused by Schizophyllum commune which developed after discontinuation of itraconazole administration].
We report the case of a 75-year-old woman with mucoid impaction of the bronchi (MIB) due to Schizophyllum commune who improved with itraconazole (ITCZ) administration and relapsed after discontinuation of the drug. She improved again after readministration of ITCZ, and MIB has not recurred. This patient was not suffering from asthma and has been well without steroid administration. Reports of respiratory disorders due to S. commune have been increasing, and cases of allergic bronchopulmonary mycosis (ABPM), fungus ball, lung abscess, and pneumonia have been reported. Including this report, 12 cases of ABPM and MIB due to S. commune have been reported by Japanese authors. Treatment in these 12 cases included anti-fungal agent in 6, single steroid therapy in 3, combination therapy in 2, and bronchial toilet in 1 case. S. commune is not well recognized; however, one should suspect this fungus to be the causative pathogen when Aspergillus species are not detected or anti-Aspergillus antibody is negative.
Ishiguro
Takashi
T
Respiratory Medicine, Saitama Cardiovascular and Respiratory Center.
Takayanagi
Noboru
N
Harasaw
Keiji
K
Yoshii
Yutaka
Y
Matsushita
Aya
A
Yoneda
Koichiro
K
Miyahara
Yousuke
Y
Kagiyama
Naho
N
Tokunaga
Daido
D
Aoki
Fumiaki
F
Saito
Hiroo
H
Ubukata
Mikio
M
Kurashima
Kazuyoshi
K
Yanagisawa
Tsutomu
T
Sugita
Yutaka
Y
Kawabata
Yoshinori
Y
Kamei
Katsuhiko
K
D000368:Aged; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D012008:Recurrence; D012567:Schizophyllum
D017964:Itraconazole