Molecular epidemiological study on prevalence of human papillomaviruses in patients with common warts in Beijing area.
OBJECTIVE
To study the circulation, distribution, and genomic diversity of HPVs in common warts in Beijing area of China.


METHODS
Forty eight patients with pathologically diagnosed common warts were screened for the presence of HPV with HPV type-specific PCR and direct sequencing analysis. The genomic diversity of HPVs prevalent in Chinese patients was analyzed based on LCR.


RESULTS
Forty one (85.5%) samples were positive for HPV DNA, 13 (31.7%)--HPV-57, 12 (29.3%)--HPV-1a, 7 (17%)--HPV-27 and 5(12.2%)--HPV-2a. Four cases were infected with two different HPV types, two (4.9%) with HPV-1a and HPV-27, one (2.4%) with HPV-1 and HPV-57 and one (2.4%) with HPV-27 and HPV-57. In contrast to the prevalence of single strain of novel HPV-57 variant and HPV-1 prototype, two HPV-2 and three HPV-27 novel variants were found to circulate in Beijing.


CONCLUSIONS
HPV-1, -2, -27 and -57 are predominantly prevalent in patients with common warts in Beijing.
Lei
Yan-Jun
YJ
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.
Gao
Chen
C
Wang
Chen
C
Han
Jun
J
Chen
Jian-Ming
JM
Xiang
Guang-Cai
GC
Shi
Qi
Q
Jiang
Hui-Ying
HY
Zhou
Wei
W
An
Run
R
Dong
Chen-Fang
CF
Yuan
Yu-Kang
YK
Dong
Xiao-Ping
XP
D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D004279:DNA, Viral; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010802:Phylogeny; D015995:Prevalence; D014860:Warts / Q000453:epidemiology* / Q000821:virology
D004279:DNA, Viral