title: Effect of landiolol hydrochloride on suxamethonium-induced neuromuscular block.
abstract: OBJECTIVE
  The aim of this study was to examine the effect of landiolol hydrochloride, an ultrashort-acting beta(1)-blocker, on suxamethonium-induced neuromuscular block.
  
  
  METHODS
  Thirty patients were randomly allocated to receive a loading dose of landiolol, 0.125 mg x kg(-1) x min(-1) for 1 min, followed by an infusion at 0.04 mg x kg(-1) x min(-1), or placebo. Twenty minutes after the infusion of landiolol or placebo, suxamethonium 1 mg x kg(-1) was administered during propofolfentanyl-nitrous oxide anesthesia. Neuromuscular block was monitored by train-of-four (TOF) responses of the adductor pollicis muscle, applying acceleromyographic stimuli to the ulnar nerve.
  
  
  RESULTS
  The onset of neuromuscular block did not differ between the groups. The time from administration of suxamethonium to spontaneous recovery to the first twitch of TOF (T1) of control was significantly longer in the landiolol group (mean [SD]; 12.2 [2.5] min), when compared with the control group (9.8 [2.6] min). However, the TOF ratios measured when the T1 had spontaneously recovered to 10%, 25%, 50%, 75%, 90%, and 100% of control was comparable between the groups.
  
  
  CONCLUSIONS
  Landiolol delayed recovery from suxamethonium-induced paralysis. However, the interaction between the drugs seemed to be small in the clinical setting.
authors.affiliation: Department of Anesthesiology, Surugadai Nihon University Hospital, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8309, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Mayu
authors.initials: M
authors.lastname: Aono
authors.forename: Tomomi
authors.initials: T
authors.lastname: Isaka
authors.forename: Eri
authors.initials: E
authors.lastname: Miyake
authors.forename: Naoko
authors.initials: N
authors.lastname: Fukano
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saeki
authors.forename: Setsuro
authors.initials: S
authors.lastname: Ogawa
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000762:Anesthesia Recovery Period; D004558:Electric Stimulation; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D019148:Neuromuscular Blockade; D009467:Neuromuscular Depolarizing Agents; D011229:Preanesthetic Medication; D013390:Succinylcholine; D014459:Ulnar Nerve / Q000502:physiology; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D009025:Morpholines; D009467:Neuromuscular Depolarizing Agents; C077049:landiolol; D014508:Urea; D013390:Succinylcholine