[Key sperm membrane proteins in sperm-egg fusion].
Fertilization is a complex process involving multiple steps, of which sperm-egg fusion is most important. This article presents a detailed review of some of the key sperm membrane proteins closely related with fertilization, such as the Izumo, the ADAMs gene family and the Crisp gene family proteins, which is of practical significance for deeper insights into the mechanisms of sperm-egg fusion, as well as for the improvement of clinical diagnosis of male infertility and development of novel contraceptive drugs.
Liu
Li-min
LM
Research Center for Reproductive Medicine, Department of Cell Biology and Genetics, Medical College of Shantou University, Shantou, Guangdong 515041, China. liulimin_123@yahoo.cn
Chen
De-yu
DY
Huang
Tian-hua
TH
D000818:Animals; D002459:Cell Fusion; D015870:Gene Expression; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009865:Oocytes / Q000166:cytology / Q000378:metabolism*; D029589:Seminal Plasma Proteins / Q000235:genetics / Q000378:metabolism; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000166:cytology / Q000378:metabolism*
D008565:Membrane Proteins; D029589:Seminal Plasma Proteins