Bone mineral density in patients with rapidly destructive or common hip osteoarthritis.
BACKGROUND
Recent findings that subchondral insufficiency fracture in the femoral head may precede rapid chondrolysis suggest a role for systemic low bone mass in the genesis of rapidly destructive hip osteoarthritis (RDHOA).


OBJECTIVE
To compare bone mineral density (BMD) in females with RDHOA and those with common hip osteoarth-ritis (OA).


METHODS
This prospective case-control study involved 26 females with RDHOA recruited from our institution between March 2000 and November 2006. BMD was measured at the femoral neck and lumbar spine (L1-L4) by dual-energy x-ray absorptiometry. For comparison, BMD was measured in 33 women with common hip OA who were scheduled for primary total hip arthroplasty.


RESULTS
Patients with RDHOA and those with common hip OA were similar in age (74.9+/-9.9 vs. 74.7+/-8.8 years) and BMI (26.3+/-4.3 vs. 26.3+/-5 g/m2) and did not differ in mean BMD at the lumbar spine (1.0+/-0.2 vs. 1.1+/-0.2 g/cm2; mean T-score: -0.6+/-1.3 vs. -0.8+/-1.5) or at the femoral neck (0.7+/-0.1 vs. 0.8+/-0.2 g/cm2; mean T-score: -1.5+/-1.1 vs. -1.4+/-1.4).


CONCLUSIONS
The results of this study do not suggest a role for systemic low bone mass in the pathophysiology of RDHOA.
Richette
P
P
Fédération de Rhumatologie, Hôpital Lariboisière, Hôpital Fernand Widal, UFR médicale, Assistance Publique-Hôpitaux de Paris, Université Paris 7, 75475 Paris Cedex 10, France. pascal.richette@lrb.aphp.fr
Vicaut
E
E
de Vernejoul
M-C
MC
Orcel
P
P
Bardin
T
T
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000502:physiology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000473:pathology*; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology*; D015207:Osteoarthritis, Hip / Q000473:pathology* / Q000503:physiopathology*; D011446:Prospective Studies