title: A new model for the assay of comedolytic activity.
abstract: Synopsis An experimental model using the 'Rhino' hairless mouse has been developed for screening comedolytic agents. The skin of this animal presents a high density of spontaneous comedos which appear in histological slices as cystic formations with a large diameter (D) and an open narrow neck (d). The ratio d/D expresses the 'comedo profile'. Statistical evaluation of this value by standardized measurement allows the quantification of comedolytic activity of pharmacological agents.
authors.affiliation: Secteur de Dermatologie Expérimentale, Laboratoire de Pathologie Expérimentale, Faculté Necker-Enfants Malades, 156 rue de Vaugirard, 75015 Paris.
authors.forename: C
authors.initials: C
authors.lastname: Bonne
authors.forename: F
authors.initials: F
authors.lastname: Zeziola
authors.forename: J
authors.initials: J
authors.lastname: Secchi
authors.forename: J H
authors.initials: JH
authors.lastname: Saurat