title: Coronary flow slows as renal function worsens.
abstract: BACKGROUND
  Slow coronary flow in patients without obstructive coronary artery disease is an angiographic finding that could easily be detected by thrombolysis in myocardial infarction (TIMI) frame counts. On the other hand, impaired renal function is a frequent problem. We searched the association between the 2 entities.
  
  
  OBJECTIVE
  We evaluated the impact of impaired renal function on slow coronary flow.
  
  
  METHODS
  In this study, 105 patients with normal coronary arteries and impaired renal function in the form of a calculated glomerular filtration rate (GFR) < 90 mL/min/1.73 m(2) were enrolled and compared with 102 age- and sex-matched controls who had normal a GFR.
  
  
  RESULTS
  Calculated GFR was found to be negatively correlated with TIMI frame count in LAD (r = - 0.579, p < 0.001), in CX (r = - 0.499, p < 0.001), and in RCA (r = - 0.491, p < 0.001) in patients with impaired renal function. After adjusting for systolic and diastolic blood pressure and high-density lipoprotein (HDL) cholesterol, multiple regression analysis demonstrated a statistically significant and independent relationship between TIMI frame count for 3 vessels and calculated GFR.
  
  
  CONCLUSIONS
  Impaired renal function seems to denote slower coronary flow in patients with normal coronary arteries compared with those with normal renal function, and there seems to be an independent association between GFR and TIMI frame count in those with impaired renal function.
authors.affiliation: Department of Cardiology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Mehmet Birhan
authors.initials: MB
authors.lastname: Yilmaz
authors.forename: Kenan
authors.initials: K
authors.lastname: Yalta
mesh_terms: D016022:Case-Control Studies; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D013223:Statistics as Topic