title: Infantile colic.
abstract: BACKGROUND
  Infantile colic causes one in six families (17%) with children to consult a health professional. One systematic review of 15 community-based studies found a wide variation in prevalence, which depended on study design and method of recording.
  
  
  METHODS
  We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for infantile colic? We searched: Medline, Embase, The Cochrane Library and other important databases up to January 2007 (BMJ Clinical evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
  
  
  RESULTS
  We found 23 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
  
  
  CONCLUSIONS
  In this systematic review we present information relating to the effectiveness and safety of the following interventions: advice to increase carrying, advice to reduce stimulation, casein hydrolysate milk, cranial osteopathy, crib vibrator device, focused counselling, gripe water, infant massage, low-lactose milk, simethicone, soya-based infant feeds, spinal manipulation, whey hydrolysate milk.
authors.affiliation: Department of general practice, Radbound University Nijmegen, Nijmegen, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Lucassen
mesh_terms: D000818:Animals; D001942:Breast Feeding; D003085:Colic / Q000628:therapy; D006801:Humans; D041943:Infant Formula; D052200:Limosilactobacillus reuteri; D008892:Milk; D019936:Probiotics / Q000627:therapeutic use; D012107:Research Design; D012841:Simethicone; D000067796:Whey
chemical_list: D012841:Simethicone