PET imaging of redox and energy states in stroke-like episodes of MELAS.
In stroke-like episodes of patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), changes in oxidative stress and glucose metabolism and their sequence remain obscure. We developed a novel double imaging method using positron emission tomography (PET) with [(62)Cu]-diacetyl-bis(N4-methylthiosemicarbazone) ((62)Cu-ATSM) and [(18)F]-fluorodeoxyglucose ((18)FDG) to visualize the regional oxidative stress, glucose metabolism and blood flow in brain lesions of stroke-like episodes non-invasively and rapidly. These PET imagings were performed on a MELAS patient with stroke-like lesions, and clearly demonstrated that oxidative stress following hyperemia along with increased glucose metabolism plays crucial roles in the pathogenesis of MELAS stroke-like episodes.
Ikawa
Masamichi
M
Second Department of Internal Medicine (Neurology), Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaiduki, Matsuoka, Eiheiji-cho, Fukui 910-1193, Japan.
Okazawa
Hidehiko
H
Arakawa
Kenichiro
K
Kudo
Takashi
T
Kimura
Hirohiko
H
Fujibayashi
Yasuhisa
Y
Kuriyama
Masaru
M
Yoneda
Makoto
M
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017241:MELAS Syndrome / Q000473:pathology*; D018384:Oxidative Stress; D049268:Positron-Emission Tomography; D011859:Radiography; D012039:Regional Blood Flow
D005947:Glucose