Pyoderma gangrenosum: an updated review.
Pyoderma gangrenosum is a rare, ulcerative, cutaneous condition. First described in 1930, the pathogenesis of pyoderma gangrenosum remains unknown, but it is probably related to a hyperergic reaction. There are various clinical and histological variants of this disorder. Pyoderma gangrenosum often occurs in association with a systemic disease such as inflammatory bowel disease, rheumatologic disease, paraproteinaemia, or haematological malignancy. The diagnosis, mainly based on the clinical presentation and course, is confirmed through a process of elimination of other causes of cutaneous ulcers. Local treatment may be sufficient for mild disease, while for severe cases, systemic immunosuppressants are the mainstay. Long-term treatment with these agents is often required, but this can expose patients to adverse side-effects.
Ruocco
E
E
Department of Dermatology, Second University of Naples, Naples, Italy.
Sangiuliano
S
S
Gravina
A G
AG
Miranda
A
A
Nicoletti
G
G
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000175:diagnosis; D003424:Crohn Disease / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D011379:Prognosis; D017511:Pyoderma Gangrenosum / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents