title: Comparison of electrodesiccation and potassium-titanyl-phosphate laser for treatment of dermatosis papulosa nigra.
abstract: BACKGROUND
  There is a lack of randomized split-face studies investigating treatments for dermatosis papulosa nigra (DPN) in dark skin.
  
  
  OBJECTIVE
  To compare the efficacy, safety, and tolerability of potassium-titanyl-phosphate (KTP) laser with efficacy, safety, and tolerability of electrodesiccation in the treatment of DPN in subjects with Fitzpatrick skin phototypes IV to VI.
  
  
  METHODS
  Fourteen subjects with Fitzpatrick skin phototypes IV to VI were randomized to receive two KTP laser treatments 4 weeks apart to half of the face. The contralateral half received two electrodesiccation treatments 4 weeks apart. Response was evaluated by photography reviewed by blinded dermatologists at 4 weeks after the second treatment. A treatment quality questionnaire about side effects and cosmetic outcome was also administered.
  
  
  RESULTS
  Difference in improvement of DPN between the KTP side and the electrodesiccation side per each rater (p=.99, p=.54) and per raters combined (p=.50) did not reach statistical significance. There was no treatment difference for subjective effectiveness (p=.06) or subjective confidence improvement (p=.99), although there was a significant treatment difference for subjective discomfort (p=.002) in favor of KTP. Both treatments were well tolerated without significant adverse effects.
  
  
  CONCLUSIONS
  Although treatment of DPN with KTP laser and electrodesiccation are comparable in efficacy, KTP laser is preferable for patient comfort.
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. rkundu@nmff.org
authors.forename: Roopal V
authors.initials: RV
authors.lastname: Kundu
authors.forename: Smita S
authors.initials: SS
authors.lastname: Joshi
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Suh
authors.forename: Susan L
authors.initials: SL
authors.lastname: Boone
authors.forename: Richard H
authors.initials: RH
authors.lastname: Huggins
authors.forename: Murad
authors.initials: M
authors.lastname: Alam
authors.forename: Lucile
authors.initials: L
authors.lastname: White
authors.forename: Alfred W
authors.initials: AW
authors.lastname: Rademaker
authors.forename: Dennis P
authors.initials: DP
authors.lastname: West
authors.forename: Simon
authors.initials: S
authors.lastname: Yoo
mesh_terms: D000328:Adult; D004564:Electrocoagulation; D005148:Facial Dermatoses / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D010781:Photography; D011446:Prospective Studies; D016037:Single-Blind Method; D012880:Skin Pigmentation; D011795:Surveys and Questionnaires; D016896:Treatment Outcome