title: Alkylation of 2,4-(1H,3H)-quinazolinediones with dialkyl carbonates under microwave irradiations.
abstract: Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties.We now report application of a practical alkylation procedure to several quinazolinediones, including pelanserine (5f), which shows antihypertensive properties, 1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione (1ab) and 1-methyl-3-[2'-(4'-methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione (1ae), which had been isolated from natural sources. The alkylation was optimized using dimethyl and diethyl carbonates under microwave irradiations.
authors.affiliation: Centro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, Tijuana, BC, Mexico. irivero@tectijuana.mx
authors.forename: Ignacio Alfredo
authors.initials: IA
authors.lastname: Rivero
authors.forename: Leticia
authors.initials: L
authors.lastname: Guerrero
authors.forename: Karla Alejandra
authors.initials: KA
authors.lastname: Espinoza
authors.forename: Martha Cecilia
authors.initials: MC
authors.lastname: Meza
authors.forename: Jesús Ramón
authors.initials: JR
authors.lastname: Rodríguez
mesh_terms: D000478:Alkylation; D000959:Antihypertensive Agents / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D011799:Quinazolines / Q000737:chemistry; D052999:Quinazolinones / Q000737:chemistry*
chemical_list: D000959:Antihypertensive Agents; D002254:Carbonates; D011799:Quinazolines; D052999:Quinazolinones; C043157:pelanserin