Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents.
Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC(50): based on reduction of BVDV replication-induced cell destruction) and 50% cytotoxic concentration (CC(50): based on reduction of viable cell number) values of 6.2-8.4 microM and >100 microM, respectively, in Madin-Darby bovine kidney (MDBK) cells infected with BVDV.
Hosoda
Shinnosuke
S
Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Aoyama
Hiroshi
H
Goto
Yukinori
Y
Salim
Mohammed T A
MT
Okamoto
Mika
M
Hashimoto
Mariko
M
Baba
Masanori
M
Hashimoto
Yuichi
Y
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001559:Benzhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000188:drug therapy; D002417:Cattle; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D013256:Steroids / Q000737:chemistry; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D001559:Benzhydryl Compounds; D013256:Steroids; C010129:diphenylmethane