title: Netting neutrophils   in autoimmune   small-vessel vasculitis.
abstract: Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.
authors.affiliation: Department of Neuroimmunology,Max-Planck-Institute of Neurobiology, Martinsried, Germany. kai.kessenbrock@ucsf.edu
authors.forename: Kai
authors.initials: K
authors.lastname: Kessenbrock
authors.forename: Markus
authors.initials: M
authors.lastname: Krumbholz
authors.forename: Ulf
authors.initials: U
authors.lastname: Schönermarck
authors.forename: Walter
authors.initials: W
authors.lastname: Back
authors.forename: Wolfgang L
authors.initials: WL
authors.lastname: Gross
authors.forename: Zena
authors.initials: Z
authors.lastname: Werb
authors.forename: Hermann-Josef
authors.initials: HJ
authors.lastname: Gröne
authors.forename: Volker
authors.initials: V
authors.lastname: Brinkmann
authors.forename: Dieter E
authors.initials: DE
authors.lastname: Jenne
mesh_terms: D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D008833:Microcirculation / Q000276:immunology*; D053146:Myeloblastin / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology*
chemical_list: D001324:Autoantigens; D053146:Myeloblastin