"Omic" risk assessment.
Integration of data from different techniques is the key to effective validation of "hits" in large-scale screens. A discussion of validation methods for siRNA screens and protein-interaction screens reveals how to go beyond an arbitrary assignment of relevant to a more biologically meaningful identification of targets.
Major
Michael B
MB
Moon
Randall T
RT
D015153:Blotting, Western; D002846:Chromatography, Affinity; D023281:Genomics; D006801:Humans; D013058:Mass Spectrometry; D009369:Neoplasms / Q000235:genetics; D040901:Proteomics; D034741:RNA, Small Interfering; D018570:Risk Assessment
D034741:RNA, Small Interfering