title: Preparation and in vitro evaluation of solid dispersions of total flavones of Hippophae rhamnoides L.
abstract: The purpose of this study was to enhance the dissolution of total flavones of Hippophae rhamnoides L. (TFH) by solid dispersions consisting of the drug and a polymeric carrier, poloxamer 188 (PXM). The solvent evaporation method was used to prepare solid dispersions. A 3(2) full-factorial design approach was used for optimization wherein the amount of solvent (X(1)) and the drug-to-polymer ratio (X(2)) were selected as independent variables and the percentage of TFH dissolved in 10 min (Q(10)) was selected as the dependent variable. Multiple linear regression analysis revealed that a suitable level of (1) and X(2) was required for obtaining higher dissolution of TFH from PXM solid dispersions. Solid dispersions were characterized by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and dissolution tests. Characterization studies revealed that solid dispersion of TFH-PXM showed enhancement of TFH dissolution due to the conversion of TFH into a less crystalline and/or amorphous form. In conclusion, dissolution enhancement of TFH was obtained by preparing its solid dispersions in PXM using solvent method.
authors.affiliation: Shanghai University of Traditional Chinese Medicine, Science and Technology Center, Shanghai, 201203, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xie
authors.forename: Guowen
authors.initials: G
authors.lastname: Li
authors.forename: Xiurong
authors.initials: X
authors.lastname: Yuan
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Cai
authors.forename: Rong
authors.initials: R
authors.lastname: Rong
mesh_terms: D002152:Calorimetry, Differential Scanning; D047309:Flavones / Q000737:chemistry*; D031281:Hippophae / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry; D012107:Research Design; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D047309:Flavones; D020442:Poloxamer