Gender differences in acute cadmium-induced systemic inflammation in rats.
OBJECTIVE
To examine the presence of gender differences in pro-inflammatory potential of cadmium in rats by comparing systemic inflammatory response to acute cadmium intoxication in animals of the two sexes.


METHODS
Basic aspects of this response were evaluated, including plasma levels of inflammatory cytokines tumor necrosis factor (TNF) and interleukin-6 (IL-6) and of major rat acute phase protein alpha 2-macroglobulin (alpha2-M), as soluble indicators of inflammation, and the number and activity of peripheral blood leukocytes, as cellular indicators of inflammation.


RESULTS
Differential increases of IL-6 and alpha2-M (higher in males than in females) in peripheral blood cell counts and types (leukocytosis and shift in the ratio of granulocytes to lymphocytes more pronounced in males vs females) and in levels of neutrophil priming (higher in males vs females) were noted.


CONCLUSIONS
The data document a more intense inflammatory response to cadmium administration in males. The sex differences in inflammatory effects of cadmium might be taken into consideration in studying the toxicity of this heavy metal.
Kataranovski
Milena
M
Department of Ecology, Institute for Biological Research Sinisa Stankovic, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia. milena@ibiss.bg.ac.yu
Janković
Srdja
S
Kataranovski
Dragan
D
Stosić
Jelena
J
Bogojević
Desa
D
D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007249:Inflammation / Q000139:chemically induced*; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D000511:alpha-Macroglobulins / Q000032:analysis
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D000511:alpha-Macroglobulins; D002104:Cadmium