title: [The changes of phosphorylated c-Jun expression in spiral ganglion after exposed to noise].
abstract: OBJECTIVE
  To investigate the mechanism of hearing pathway NMDAR regulating the changes of phosphorylated c-Jun expression in spiral ganglion after exposed Kunming mice to neural injury noise stimulation to induce permanent or temporary threshold shift.
  
  
  METHODS
  To compare the different expressions of the key components (phosphorylated C-Jun) of NMDAR signal pathway during neural injury stimulation by Immunohistochemistry in CG.
  
  
  RESULTS
  The levels of phosphorylated c-Jun remarkably, increased in the spiral ganglion after 8 h, 48 h, 7 d and 14 d following noise trauma induced permanent threshold shift (PTS), and the numbers of positive cells reduced gradually. The similar changes occur in mice treated with MK-801 30 minutes before and after 3 h trauma induced PTS. After 48 h of noise induced TTS, the expression of Phosphorylated c-Jun return the level of normal control.
  
  
  CONCLUSIONS
  The expressions of phosphorylated c-Jun are time-related and uniform in the time and position in CG after noise trauma. MK-801 can alleviate the damage of noise trauma by altered the NMDA receptor-mediated calcium influx. Therefore, the NMDA receptors may involved in the damage of inner ear in common.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, 100730, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Xia
authors.forename: Haishan
authors.initials: H
authors.lastname: Long
authors.forename: Demin
authors.initials: D
authors.lastname: Han
authors.forename: Shusheng
authors.initials: S
authors.lastname: Gong
authors.forename: Li
authors.initials: L
authors.lastname: Lei
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Shi
authors.forename: Erzhong
authors.initials: E
authors.lastname: Fan
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea / Q000378:metabolism; D006317:Hearing Loss, Noise-Induced / Q000378:metabolism*; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D013136:Spiral Ganglion / Q000378:metabolism*
chemical_list: D048031:JNK Mitogen-Activated Protein Kinases