A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt.
A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP x 3HCl x H(2)O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H(2)/Pd/C/C(2)H(5)OH system was developed. The products were characterized by TG, IR, (1)H-NMR, (13)C-NMR, HPLC and elemental analysis.
Wang
Yanhong
Y
Department of Applied Chemistry, Faculty of Science, Harbin Institute of Technology, Harbin, PR China. yanhongwang0213@gmail.com
Hu
Zhen
Z
Meng
Xiangli
X
Jing
Jiehui
J
Song
Yuanjun
Y
Zhang
Chunhua
C
Huang
Yudong
Y
D000631:Aminopyridines / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D015394:Molecular Structure; D017942:Nitric Acid / Q000737:chemistry; D012492:Salts / Q000138:chemical synthesis* / Q000737:chemistry
D000631:Aminopyridines; D012492:Salts; D017942:Nitric Acid