title: Lidocaine patch for postoperative analgesia after radical retropubic prostatectomy.
abstract: In a prospective, double-blind, placebo-controlled study, patients undergoing radical retropubic prostatectomy under general anesthesia were randomly assigned to receive a lidocaine patch or placebo applied on each side of the wound at the end of surgery. Data were collected for 24 h after surgery. Seventy patients completed the study (36 lidocaine group, 34 placebo group). Demographics and postoperative morphine consumption were not different between the groups. However, the lidocaine patch group reported significantly less pain on coughing (19%-33% reduction) over all time periods (treatment vs placebo P < 0.0001, time x treatment P = 0.3056) and at rest (17%-32% reduction) for up to 6 h (treatment vs placebo P = 0.0003, time x treatment P = 0.0130).
authors.affiliation: Department of Anesthesiology, Duke University Medical System, Box 3094, Durham, NC 27710, USA. habib001@mc.duke.edu
authors.forename: Ashraf S
authors.initials: AS
authors.lastname: Habib
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Polascik
authors.forename: Alon Z
authors.initials: AZ
authors.lastname: Weizer
authors.forename: William D
authors.initials: WD
authors.lastname: White
authors.forename: Judd W
authors.initials: JW
authors.lastname: Moul
authors.forename: Magdi A
authors.initials: MA
authors.lastname: ElGasim
authors.forename: Tong J
authors.initials: TJ
authors.lastname: Gan
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000187:drug effects; D010149:Postoperative Pain / Q000188:drug therapy*; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology; D011446:Prospective Studies; D011468:Prostatectomy
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine