title: Scan-time reduction using noise-matched images in 2- and 3-dimensional bismuth germanate PET/CT: clinical study in head and neck cancer.
abstract: We quantitatively and qualitatively investigated 2-dimensional (2D) and 3-dimensional (3D) imaging with scan-time reduction in 14 patients with 17 lesions, who had known or suspected head and neck cancer, using a bismuth germanate (BGO) crystal based PET/CT scanner with noise-matched images.
  
  
  METHODS
  A 2D and 3D acquisition protocol using scan-time reduction on an axial single field of view resulted in a 2D 4-, 3D 4-, 3D 3-, 2D 3-, 2D 2-, and 3D 2-min scan sequence to minimize redistribution and decay bias. Tumor maximum standardized uptake values (SUVmax) and tumor mean standardized uptake values (SUV(mean)) were recorded, and two observers in consensus investigated lesion conspicuity between 2D and 3D paired 4-, 3-, and 2-min noise-matched images.
  
  
  RESULTS
  We found some minor advantages quantitatively in favor of 2D scanning, with higher mean SUVmax, and qualitatively in favor of 3D scanning, with lesion conspicuity preference. In our cohort, no great advantage or disadvantage to using either acquisition mode was observed, and all lesions were seen irrespective of acquisition mode and scan time.
  
  
  CONCLUSIONS
  In head and neck cancer patients, we can recommend a scan-time reduction from 4 to 3 min/bed position in 2D acquisitions with a BGO-based PET/CT scanner, using our imaging protocol and reconstruction defaults.
authors.affiliation: Paul Strickland Scanner Centre, Mount Vernon Hospital, Middlesex, United Kingdom. bal.sanghera@nhs.net
authors.forename: Bal
authors.initials: B
authors.lastname: Sanghera
authors.forename: Gerry
authors.initials: G
authors.lastname: Lowe
authors.forename: David
authors.initials: D
authors.lastname: Wellstead
authors.forename: John
authors.initials: J
authors.lastname: Lowe
authors.forename: Jane
authors.initials: J
authors.lastname: Chambers
authors.forename: WaiLup
authors.initials: W
authors.lastname: Wong
mesh_terms: D001729:Bismuth / Q000378:metabolism; D005260:Female; D005857:Germanium / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D049268:Positron-Emission Tomography / Q000379:methods*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D005857:Germanium; C042364:bismuth germanium oxide; D001729:Bismuth