Association of distinct clinical subsets with myositis-specific autoantibodies towards anti-155/140-kDa polypeptides, anti-140-kDa polypeptides, and anti-aminoacyl tRNA synthetases in Japanese patients with dermatomyositis: a single-centre, cross-sectional study.
OBJECTIVE
To determine the association of distinct clinical subsets with myositis-specific autoantibodies (MSAs) towards anti-155/140-kDa polypeptides [anti-155/140 antibodies (Abs)], anti-140-kDa polypeptides (anti-140 Abs), and anti-aminoacyl tRNA synthetases (ARS Abs) in Japanese patients with dermatomyositis (DM).


METHODS
We compared the clinical features and short-term prognoses of 30 DM patients whose serological status included these MSAs. The MSAs were determined by immunoprecipitation.


RESULTS
Anti-155/140 Abs (n = 5), anti-140 Abs (n = 8), and anti-ARS Abs (n = 7) did not overlap each other. All of the anti-155/140 Ab-positive patients (n = 5) were complicated by malignancies, as were all of the anti-140 Ab-positive patients (n = 8), who showed rapidly progressive interstitial lung disease (ILD). The survival rate at 6 months from the diagnosis of DM was significantly lower in the anti-140 Ab-positive patients than in the other patients.


CONCLUSIONS
This is the first study to report, in a single cohort of DM patients, that distinct clinical subsets are distributed in an anti-155/140 Ab-positive group, an anti-140 Ab-positive group, or an anti-ARS Ab-positive group. Our data also confirm previous evidence that anti-155/140 Abs are involved in malignancies and that anti-140 Abs are involved in rapidly progressive ILD.
Fujikawa
K
K
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Kawakami
A
A
Kaji
K
K
Fujimoto
M
M
Kawashiri
S
S
Iwamoto
N
N
Aramaki
T
T
Ichinose
K
K
Tamai
M
M
Kamachi
M
M
Nakamura
H
H
Ida
H
H
Origuchi
T
T
Ishimoto
H
H
Mukae
H
H
Kuwana
M
M
Kohno
S
S
Takehara
K
K
Sato
S
S
Eguchi
K
K
D000328:Adult; D000368:Aged; D000604:Amino Acyl-tRNA Synthetases / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003882:Dermatomyositis / Q000175:diagnosis* / Q000276:immunology*; D005260:Female; D006801:Humans; D047468:Immunoprecipitation; D007564:Japan; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000276:immunology; D011336:Probability; D012343:RNA, Transfer / Q000276:immunology*; D018709:Statistics, Nonparametric
D001323:Autoantibodies; D010455:Peptides; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases