title: [The multi-target drugs and their design].
abstract: The reduce of bioactivity and augment of the side effect of single-target drugs is generated by the multi-factorial properties of the pathogenesis of disease, which could be solved by the multi-target drugs. The problems and its solution of the design of the multi-target drugs were discussed in this paper, at the same time, the design of the multi-target drugs by pharmacophore model method is presented.
authors.affiliation: School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, China. fengchao@mails.tjmu.edu.cn
authors.forename: Feng-chao
authors.initials: FC
authors.lastname: Jiang
mesh_terms: D017076:Computer-Aided Design; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D004338:Drug Combinations