Improved copper(I)-NHC catalytic efficiency on huisgen reaction by addition of aromatic nitrogen donors.
A simple addition with a large impact: Addition of aromatic amines such as phenanthroline and 4-DMAP (4-dimethylaminopyridine) increases copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) catalytic activity of [CuCl(SIMes)] at a large range of temperatures in such a way that efficient catalysis can safely take place in hydro-alcoholic solvents (see scheme).
Teyssot
Marie-Laure
ML
Clermont Université, SEESIB, UMR CNRS 6504, Université Blaise Pascal, 24 Avenue des Landais, 63177 Aubière CEDEX, France.
Chevry
Aurélien
A
Traïkia
Mounir
M
El-Ghozzi
Malika
M
Avignant
Daniel
D
Gautier
Arnaud
A
D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*; D012997:Solvents; D013696:Temperature
D000438:Alcohols; D000480:Alkynes; D001386:Azides; D010618:Phenanthrolines; D012997:Solvents; D003300:Copper; D015761:4-Aminopyridine; D009584:Nitrogen; C003885:4-dimethylaminopyridine