Shiga-like toxins and HIV-1 'go through' glycosphingolipids and lipid rafts in renal cells.
The binding of Shiga-like toxins (Stx) to globotriaosyl ceramide (Gb(3)) in renal cells plays a central role in Stx-induced hemolytic uremic syndrome (Stx-HUS). Khan et al. show that the presence of Gb(3) within lipid raft microdomains in glomerular but not tubular cells may be the basis for the glomerular- and age-restricted pathology of Stx-HUS. They also propose that the binding of the HIV-1 glycoprotein gp120 to Gb(3) in renal tubules may play a role in HIV nephropathy.
Ray
Patricio E
PE
Division of Nephrology, Children's Research Institute, Children's National Medical Center, and Department of Pediatrics, The George Washington University, Washington, DC, USA. Electronic address: Pray@cnmc.org.
D016263:AIDS-Associated Nephropathy / Q000209:etiology; D006028:Glycosphingolipids / Q000378:metabolism*; D015699:HIV Envelope Protein gp120 / Q000493:pharmacokinetics; D015497:HIV-1 / Q000737:chemistry / Q000472:pathogenicity*; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology; D007684:Kidney Tubules / Q000378:metabolism / Q000473:pathology; D021962:Membrane Microdomains / Q000378:metabolism* / Q000821:virology; D010539:Permeability; D011485:Protein Binding; D011500:Protein Synthesis Inhibitors / Q000493:pharmacokinetics; D021381:Protein Transport; D022603:Shiga Toxins / Q000493:pharmacokinetics*
D006028:Glycosphingolipids; D015699:HIV Envelope Protein gp120; D011500:Protein Synthesis Inhibitors; D022603:Shiga Toxins