GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.
OBJECTIVE
A single nucleotide polymorphism in the 3'-untranslated region of the progranulin gene (GRN; 3'UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN.


METHODS
As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland.


RESULTS
No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis).


CONCLUSIONS
This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.
Jasinska-Myga
B
B
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. jasinskamyga.barbara@mayo.edu
Wider
C
C
Opala
G
G
Krygowska-Wajs
A
A
Barcikowska
M
M
Czyzewski
K
K
Baker
M
M
Rademakers
R
R
Uitti
R J
RJ
Farrer
M J
MJ
Ross
O A
OA
Wszolek
Z K
ZK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D000077153:Progranulins; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics; D055815:Young Adult
C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins