title: Low-dose aspirin has no impact on systemic level of serine protease inhibitors in healthy volunteers.
abstract: Low-dose aspirin (100 mg/day) was recently found to increase serum levels of alpha-1 protease inhibitor (A1-PI). Here, we studied the serum levels of 2 major serine protease inhibitors, A1-PI and serine leukocyte protease inhibitor (SLPI), in 10 Helicobacter pylorinegative healthy volunteers (HVs) treated with low-dose aspirin alone and in combination with other drugs.(1) Neither the treatment with low-dose aspirin alone or in combination altered serum levels of both serine protease inhibitors. The previously described increase of A1-PI levels by low-dose aspirin was most likely caused by multiple endoscopies within a few days, which caused a systemic stress response.
authors.forename: Thomas
authors.initials: T
authors.lastname: Wex
authors.forename: Gerhard
authors.initials: G
authors.lastname: Treiber
authors.forename: Alexander
authors.initials: A
authors.lastname: Link
authors.forename: Heike
authors.initials: H
authors.lastname: Wex
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D053481:Secretory Leukocyte Peptidase Inhibitor / Q000097:blood; D015842:Serine Proteinase Inhibitors / Q000097:blood*; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C506814:SLPI protein, human; D053481:Secretory Leukocyte Peptidase Inhibitor; D015842:Serine Proteinase Inhibitors; D001241:Aspirin