[The multi-target drugs and their design].
The reduce of bioactivity and augment of the side effect of single-target drugs is generated by the multi-factorial properties of the pathogenesis of disease, which could be solved by the multi-target drugs. The problems and its solution of the design of the multi-target drugs were discussed in this paper, at the same time, the design of the multi-target drugs by pharmacophore model method is presented.
Jiang
Feng-chao
FC
School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, China. fengchao@mails.tjmu.edu.cn
D017076:Computer-Aided Design; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects*
D004338:Drug Combinations