[Effects of beta 1-adrenoblocker bisoprolol on endothelial dysfunction in patients with stable angina pectoris in combination with chronic obstructive pulmonary disease].
OBJECTIVE
To study effects of a cardioselective beta-adrenoblocker bisoprolol on vascular wall endothelium and external respiration function in stable angina of effort combined with chronic obstructive pulmonary disease (COPD).


METHODS
Endothelial function and external respiration were studied before and after 4-week treatment with bisoprolol in 36 patients with stable angina and COPD using assessment of endothelium-dependent vasodilatation (EDVD) and concentrations of nitric oxide metabolites.


RESULTS
Significant improvement of endothelial function was achieved due to bisoprolol 4-week treatment which did not affect external respiration function.


CONCLUSIONS
Bisoprolol is effective and safe drug in the treatment of stable angina combined with COPD. It can noticeably improve endothelial function.
Grigor'eva
N Iu
NIu
Sharabrin
E G
EG
Kuznetsov
A N
AN
Mazalov
K V
KV
Kontorshchikova
K N
KN
Koroleva
E F
EF
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D000787:Angina Pectoris / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D017298:Bisoprolol / Q000008:administration & dosage / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D000319:Adrenergic beta-Antagonists; D017298:Bisoprolol