title: Identification of a polyketide synthase coding sequence specific for anatoxin-a-producing Oscillatoria cyanobacteria.
abstract: We report the identification of a sequence from the genome of Oscillatoria sp. strain PCC 6506 coding for a polyketide synthase. Using 50 axenic cyanobacteria, we found this sequence only in the genomes of Oscillatoria strains producing anatoxin-a or homoanatoxin-a, indicating its likely involvement in the biosynthesis of these toxins.
authors.affiliation: Unité des Cyanobactéries (URA CNRS 2172), Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Cadel-Six
authors.forename: Isabelle
authors.initials: I
authors.lastname: Iteman
authors.forename: Caroline
authors.initials: C
authors.lastname: Peyraud-Thomas
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mann
authors.forename: Olivier
authors.initials: O
authors.lastname: Ploux
authors.forename: Annick
authors.initials: A
authors.lastname: Méjean
mesh_terms: D001427:Bacterial Toxins / Q000378:metabolism; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000378:metabolism; D000087522:Cyanobacteria Toxins; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D015394:Molecular Structure; D054300:Oscillatoria / Q000201:enzymology* / Q000235:genetics; D048630:Polyketide Synthases / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014326:Tropanes / Q000378:metabolism*
chemical_list: D001427:Bacterial Toxins; D019086:Bridged Bicyclo Compounds, Heterocyclic; D000087522:Cyanobacteria Toxins; D004269:DNA, Bacterial; D014326:Tropanes; C524097:homoanatoxin-a; D048630:Polyketide Synthases; C509783:anatoxin a