title: [A case of Wegener's granulomatosis with pachymeningitis].
abstract: A 49-year-old man was admitted to our hospital because of headache, rhinorrhea, and general fatigue. Chest CT revealed some lung nodules bilaterally, and laboratory data were positive for C-ANCA. Brain MRI revealed the findings of pachymeningitis. Wegener's granulomatosis (WG) was diagnosed by the pathological findings of his paranasal sinuses and kidneys. Most of his symptoms remarkably improved with oral corticosteroids and cyclophosphamide. A MEDLINE search about WG with pachymeningitis obtained only 15 cases previously reported in Japan. Considering those reports about WG with pachymeningitis in both Japan and overseas, in some cases pachymeningitis preceded WG, and relatively more cases than normal WG were negative for C-ANCA, furthermore the pathological findings of pachymeningitis were mainly necrotizing granuloma. Therefore pachymeningitis with WG might be mainly composed of granuloma rather than angitis and which might be a expansion of granulomatous inflammation of upper respiratory tract.
authors.affiliation: Respiratory Center, Yodogawa Christian Hospital.
authors.forename: Mio
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Nishijima
authors.forename: Kyoko
authors.initials: K
authors.lastname: Inui
authors.forename: Takashi
authors.initials: T
authors.lastname: Ueji
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Akamatsu
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Imahashi
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Mikawa
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Otani
authors.forename: Kyoko
authors.initials: K
authors.lastname: Yagyu
authors.forename: Masahide
authors.initials: M
authors.lastname: Kaji
authors.forename: Takao
authors.initials: T
authors.lastname: Kamimori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujiwara
mesh_terms: D014890:Granulomatosis with Polyangiitis / Q000150:complications*; D006801:Humans; D008297:Male; D008581:Meningitis / Q000209:etiology*; D008875:Middle Aged