[Ki-67 -- new faces of an old player].
The Ki-67 protein was isolated twenty-five years ago and has become the first histological marker of proliferating cells until now. This molecule with a unique structure possesses such fundamental biological functions that are essential for normal cell proliferation. Since the Ki-67 protein is present in every dividing cell (G1, S, G2/M phase) but is absent from the resting cells (G0 phase) it is very much suitable for identifying the proliferating fraction of cells. Thus, it provides essential information concerning the malignancy of a tumor and about the prediction of response to a certain therapy. Based on its important role in cell proliferation, the Ki-67 protein might also play a role in tumor genesis. In their present work the authors discuss the history and the properties of Ki-67, its role in cell cycle regulation and its prognostic importance in different malignant disorders.
Bubán
Tamás
T
Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Belgyógyászati Intézet, I. Belgyógyászati Klinika Debrecen.
Tóth
László
L
Tanyi
Miklós
M
Kappelmayer
János
J
Antal-Szalmás
Péter
P
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics / Q000302:isolation & purification; D002453:Cell Cycle; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis / Q000235:genetics / Q000302:isolation & purification; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics / Q000302:isolation & purification; D009369:Neoplasms / Q000737:chemistry*; D011237:Predictive Value of Tests; D011379:Prognosis; D011487:Protein Conformation; D020033:Protein Isoforms / Q000032:analysis / Q000235:genetics / Q000302:isolation & purification
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D020033:Protein Isoforms