title: [Osteomalacia and giant cell tumor: a rare case].
abstract: BACKGROUND
  Oncogenic octeomalacia is an unusual and rare clinicopathologic syndrome characterized by mesenchymal tumors that apparently produce osteomalacia and biochemical abnormalities consisting of hypophosphatemia and normocalcemia.
  
  
  OBJECTIVE
  We have investigated the mechanism by which a giant cell tumor of bone caused biopsy-proved osteomalacia in a 50-year-old woman.
  
  
  METHODS
  A 50-year-old woman presented with generalized bone and pelvicrural pain, associated with fatiguability and muscle weakness. The diagnosis of osteomalacia was retained, associated with a giant cell tumor. The coexistence of giant cell tumor of bone and osteomalacia suggested the diagnosis of oncogenic osteomalacia. Resolution of the biochemical abnormalities of the syndrome after tumor resection, established this diagnosis.
  
  
  CONCLUSIONS
  oncogenic osteomalacia can be a form of vitamin-D-refractory osteomalacia due to altered vitamin D3 metabolism.
authors.affiliation: Service de Rhumatologie, Hôpital La Rabta, Tunis, Tunisie.
authors.forename: Hela
authors.initials: H
authors.lastname: Sehli
authors.forename: Lilia
authors.initials: L
authors.lastname: Daoud
authors.forename: Rim
authors.initials: R
authors.lastname: Ben Mbarek
authors.forename: Rim
authors.initials: R
authors.lastname: Ghorbel
authors.forename: Kaouther
authors.initials: K
authors.lastname: Ben Abdelghani
authors.forename: Hichem
authors.initials: H
authors.lastname: Charfi
authors.forename: Ilhem
authors.initials: I
authors.lastname: Cheour
authors.forename: Lamjed
authors.initials: L
authors.lastname: Tarhouni
authors.forename: Slaheddine
authors.initials: S
authors.lastname: Sellami
mesh_terms: D001859:Bone Neoplasms / Q000150:complications*; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D010018:Osteomalacia / Q000209:etiology* / Q000473:pathology