title: A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation.
abstract: Autoimmune-related retinopathy and optic neuropathy (ARRON) syndrome is characterized by visual loss and often the presence of antibodies against retinal or optic nerve antigens in the absence of cancer. Limited success has been reported in treatment of ARRON syndrome with medications that suppress the immune system. In many patients, current strategies are insufficient to control the disease. A 47-year-old woman with progressive visual and hearing loss attributed to ARRON syndrome that was resistant to conventional therapies underwent autologous hematopoietic stem cell transplantation (HSCT). Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome.
authors.affiliation: Department of Medicine, Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Oyama
authors.forename: Richard K
authors.initials: RK
authors.lastname: Burt
authors.forename: Charles
authors.initials: C
authors.lastname: Thirkill
authors.forename: Eissa
authors.initials: E
authors.lastname: Hanna
authors.forename: Kevin
authors.initials: K
authors.lastname: Merrill
authors.forename: John
authors.initials: J
authors.lastname: Keltner
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D015153:Blotting, Western; D004596:Electroretinography; D005136:Eye Proteins / Q000276:immunology; D005260:Female; D006311:Hearing Disorders / Q000209:etiology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000276:immunology / Q000628:therapy*; D012164:Retinal Diseases / Q000276:immunology / Q000628:therapy*; D013577:Syndrome; D014182:Transplantation, Autologous; D014786:Vision Disorders / Q000209:etiology / Q000628:therapy; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D005136:Eye Proteins