title: Pediatric acute lymphoblastic leukemia complicated by secondary hemophagocytic lymphohistiocytosis.
abstract: Hemophagocytic lymphohistiocytosis (HLH) may be familial or secondary to infections, malignancies, metabolic disorders. Infectious causes are mostly viral and EBV is the mostly frequently seen etiologic agent. In this case, we report a child with acute lymphoblastic leukemia (ALL), who had three episodes of secondary HLH, possibly due to two different viral etiologies, namely CMV and RSV together with her malignancy, during her induction-consolidation treatment.
authors.affiliation: Department of Pediatric Hematology/Oncology/BMT, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Devecioglu
authors.forename: Sema
authors.initials: S
authors.lastname: Anak
authors.forename: Didem
authors.initials: D
authors.lastname: Atay
authors.forename: Pinar
authors.initials: P
authors.lastname: Aktan
authors.forename: Esra
authors.initials: E
authors.lastname: Devecioglu
authors.forename: Beril
authors.initials: B
authors.lastname: Ozalp
authors.forename: Ebru
authors.initials: E
authors.lastname: Saribeyoglu
mesh_terms: D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D018357:Respiratory Syncytial Virus Infections / Q000150:complications