title: [Differentiated thyroid carcinoma in children: study of 80 cases].
abstract: OBJECTIVE
  The objective was to analyze the clinical profile of Differentiated Thyroid Carcinoma in children (DTC) and the predisposing factors to suffering the disease.
  
  
  METHODS
  Eighty children with DTC were studied retrospectively. They all underwent total/near total thyroidectomy and 75 cases underwent ablative iodine therapy. Patients were controlled periodically with clinical, laboratory and imaging tests follow-up.
  
  
  RESULTS
  Twenty eight patients were male and 52 female (mean age: 13.43+/-3.6 y). The 87.5% of patients had an increased cervical perimeter as the first clinical symptom, 65% of them corresponding to a thyroid nodule with a predominance of females. The papillary histological pattern was more frequent than the follicular pattern, and it was associated with the presence of lymph involvement and metastasis. About 56.4% of patients showed advanced disease at the time of diagnosis. 9 patients had previous irradiation. Surgical complications appeared in 32.5% of patients. At the end of follow-up (mean: 10.79+/-5.69 y) 9 patients had persistent disease with a significant relation with stage 4.
  
  
  CONCLUSIONS
  DTC presents a higher incidence in females than in males. Cervical node is the most frequent form of initial presentation. The papillary type is more prevalent than the follicular type, and it is frequently associated with lymph node involvement and metastatic spread.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitari Vall d'Hebron, Universitat Autónoma de Barcelona, Barcelona, Spain. monegre@yahoo.es
authors.forename: Montserrat
authors.initials: M
authors.lastname: Negre Busó
authors.forename: Marc
authors.initials: M
authors.lastname: Simó Perdigó
authors.forename: Isabel
authors.initials: I
authors.lastname: Roca Bielsa
authors.forename: Santiago
authors.initials: S
authors.lastname: Aguadé Bruix
authors.forename: José Sánchez
authors.initials: JS
authors.lastname: de Toledo
authors.forename: Joan
authors.initials: J
authors.lastname: Castell Conesa
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000175:diagnosis*