title: Bioavailability of phenolic antioxidants associated with dietary fiber: plasma antioxidant capacity after acute and long-term intake in humans.
abstract: Most studies on bioavailability of phenolic antioxidants are focused in foods and beverages in which they may be easily released from the food matrix, reaching a peak in plasma antioxidant capacity 1-2 h after the intake. However, plant foods contain significant amounts of polyphenols associated with dietary fiber. The aim of the present work was to seek the bioavailability of total phenolic antioxidants associated with dietary fiber by measuring plasma antioxidant capacity in human volunteers. An acute intake of 15 g of a dietary fiber rich in associated phenolic antioxidants in healthy volunteers (n = 10) increased antioxidant capacity of plasma in relation to a control group (n = 4), becoming significant 8 h after the intake. This shows that phenolic antioxidants associated with dietary fiber are at least partially bioavailable in humans, although dietary fiber appears to delay their absorption. No significant changes were observed after long-term intake (16 weeks, 34 subjects).
authors.affiliation: Department of Metabolism and Nutrition (ICTAN-CSIC), Calle José Antonio Novais, 10, Madrid 28040, Spain. jara@if.csic.es
authors.forename: Jara
authors.initials: J
authors.lastname: Pérez-Jiménez
authors.forename: José
authors.initials: J
authors.lastname: Serrano
authors.forename: Maria
authors.initials: M
authors.lastname: Tabernero
authors.forename: Sara
authors.initials: S
authors.lastname: Arranz
authors.forename: M Elena
authors.initials: ME
authors.lastname: Díaz-Rubio
authors.forename: Luis
authors.initials: L
authors.lastname: García-Diz
authors.forename: Isabel
authors.initials: I
authors.lastname: Goñi
authors.forename: Fulgencio
authors.initials: F
authors.lastname: Saura-Calixto
mesh_terms: D000975:Antioxidants / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology; D019540:Area Under Curve; D001682:Biological Availability; D004043:Dietary Fiber / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D010636:Phenols / Q000493:pharmacokinetics* / Q000494:pharmacology; D013997:Time Factors; D027843:Vitis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D004043:Dietary Fiber; D010636:Phenols