The rabbit biodistribution of a therapeutic dose of zoledronic acid labeled with Tc-99m.
The aim of the present study was to label a therapeutic dose of zoledronic acid (ZOL) with Tc-99m, evaluate its in vitro stability and compare its biodistribution to (99m)Tc-methylene biphosphonate ((99m)Tc-MDP) in normal rabbits. Preparation of 0.50 mg of (99m)Tc-ZOL was carried out by the reduction of (99m)Tc-pertechnetate in the presence of stannous chloride. The radiolabeling efficiency was found to be greater than 99%. The labeled complex was stable at least up to 6 h at room temperature determined by paper chromatography. (99m)Tc-ZOL and (99m)Tc-MDP were administered intravenously to the rabbits for scintigraphic studies. Between (99m)Tc-ZOL and (99m)Tc-MDP, there were no significant differences in the ratios of femur/BG and lumbar vertebrae/BG, whereas epiphysis/BG and the kidney/BG ratios of (99m)Tc-MDP were higher than (99m)Tc-ZOL at the static studies.
Asikoglu
Makbule
M
Ege University, Faculty of Pharmacy, Department of Radiopharmacy, Bornova 35100, Izmir, Turkey. makbule.asikoglu@ege.edu.tr
Durak
Funda Gamze
FG
D000818:Animals; D004164:Diphosphonates / Q000737:chemistry / Q000493:pharmacokinetics*; D004838:Epiphyses / Q000000981:diagnostic imaging / Q000378:metabolism; D005269:Femur / Q000000981:diagnostic imaging / Q000378:metabolism; D007093:Imidazoles / Q000737:chemistry / Q000493:pharmacokinetics*; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D015609:Organotechnetium Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics*; D000077211:Zoledronic Acid
D004164:Diphosphonates; D007093:Imidazoles; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D000077211:Zoledronic Acid; C027474:methylene diphosphonate