[Expression of estrogen receptor beta in benign prostatic hyperplasia complicated by chronic prostatitis].
OBJECTIVE
To observe the expression of estrogen receptor-beta (ERbeta) in benign prostatic hyperplasia (BPH) complicated by chronic prostatitis, and to evaluate the correlation of chronic prostatitis with ERbeta expression.


METHODS
Histological sections of prostate tissues were obtained from 60 BPH patients complicated by chronic prostatitis and divided into Group 1 (Grade 1), 2 (Grade 2) and 3 (Grade 3) according to the scores on the inflammation of the prostate tissues using the four-point scale designed by Irani et al. The expression of ERbeta was determined by the immunohistochemical method.


RESULTS
There were 24 cases (40%) in Group 1, 21 (35%) in Group 2 and 15 (25%) in Group 3, with no statistically significant differences in age and prostate volume among the three groups (P > 0.05). The expression of ERbeta was significantly decreased in Groups 2 and 3 as compared with Group 1 (P < 0.01).


CONCLUSIONS
The expression of ERbeta is reduced with increased scores on the inflammation of the prostate tissues in BPH patients, and the decreased ERbeta expression may be associated with the inflammatory stimulation of prostatitis.
Yang
Guo-Qing
GQ
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Li
Shi-Wen
SW
Zheng
Hang
H
Zhang
Wei-Bing
WB
Hu
Wan-Li
WL
Zheng
Xin-Min
XM
D000368:Aged; D002908:Chronic Disease; D047629:Estrogen Receptor beta / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D011472:Prostatitis / Q000150:complications / Q000378:metabolism* / Q000473:pathology
D047629:Estrogen Receptor beta