title: [Free circulating DNA based colorectal cancer screening from peripheral blood: the possibility of the methylated septin 9 gene marker].
abstract: DNA methylation acts in early tumorigenesis. Its detection is possible either from tissue, stool or peripheral blood. Septin 9 is a sensitive methylation marker, which has been studied in several cancers such as breast and ovarian tumors and in neurological or hematological diseases. Septin proteins have an important role from cytoskeleton organisation to development of embryonal pattern. Nowadays intensive researches are going on about the relation between the septin 9 gene hypermethylation and colorectal cancer development.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika, Budapest. drtothkinga@yahoo.com
authors.forename: Kinga
authors.initials: K
authors.lastname: Tóth
authors.forename: Orsolya
authors.initials: O
authors.lastname: Galamb
authors.forename: Sándor
authors.initials: S
authors.lastname: Spisák
authors.forename: Barnabás
authors.initials: B
authors.lastname: Wichmann
authors.forename: Ferenc
authors.initials: F
authors.lastname: Sipos
authors.forename: Katalin
authors.initials: K
authors.lastname: Leiszter
authors.forename: Jeannette
authors.initials: J
authors.lastname: Molnár
authors.forename: Béla
authors.initials: B
authors.lastname: Molnár
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Tulassay
mesh_terms: D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000097:blood*; D020558:GTP Phosphohydrolases / Q000097:blood* / Q000235:genetics*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D009154:Mutation; D009336:Necrosis; D009367:Neoplasm Staging; D058112:Septins
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D020558:GTP Phosphohydrolases; C474315:SEPTIN9 protein, human; D058112:Septins