title: Biochemical effects of unsaponifiable lipidic components of avocado and soya bean administered percutaneously on the connective tissue components of hairless rat skin.
abstract: Synopsis The unsaponifiable lipidic fractions of avocado and soya bean were administered percutaneously, on the dorsal skin of hairless rats for 15 days, in a 5% sweet almond oil solution. This treatment produced a modification of dermal connective tissue components. The biochemical analysis showed an increase of soluble proteins, especially of salt soluble collagen together with a decrease of proteins insoluble in neutral buffer. The ratio, soluble proteins:insoluble proteins, increases as well as the ratio soluble collagen: insoluble collagen. These modifications can be considered as a result of the activation of connective tissue metabolism. The above results are in agreement with those obtained when the unsaponifiables were administered per os to rats.
authors.affiliation: Laboratoire de Pharmacodynamie, Centre d'Etudes Pharmaceutiques, 92290 Châtenay-Malabry, France.
authors.forename: E
authors.initials: E
authors.lastname: Lamaud
authors.forename: A M
authors.initials: AM
authors.lastname: Robert
authors.forename: J
authors.initials: J
authors.lastname: Wepierre