Prepregnancy depressive mood and preterm birth in black and white women: findings from the CARDIA Study.
OBJECTIVE
We examine associations among race, prepregnancy depressive mood, and preterm birth (<37 weeks gestation) in a cohort study of black and white women.


METHODS
We tested for mediation of the association between race and preterm birth by prepregnancy depressive mood among 555 women enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.


RESULTS
Black women had significantly higher levels of prepregnancy depressive mood (modified CES-D score 13.0 vs. 9.5, t = -4.64, p < 0.001). After adjustment for covariates, black women had 2.70 times the odds of preterm birth as white women (95% confidence interval [CI] 1.41, 5.17). When adding prepregnancy depressive mood to this model, higher depressive mood was associated with greater odds of preterm birth (odds ratio [OR] 1.04; 95% CI 1.01, 1.07), and the effect of black race was attenuated (OR 2.47, 95% CI 1.28, 4.77).


CONCLUSIONS
Our data suggest that prepregnancy depressive mood may be a risk factor for preterm birth among black and white women.
Gavin
Amelia R
AR
University of Washington, School of Social Work, 4101 15th Avenue NE, Seattle, WA 98105, USA. gavina@u.washington.edu
Chae
David H
DH
Mustillo
Sarah
S
Kiefe
Catarina I
CI
D000328:Adult; D044383:Black People / Q000706:statistics & numerical data*; D015897:Comorbidity; D003863:Depression / Q000175:diagnosis / Q000208:ethnology*; D005260:Female; D006304:Health Status; D006801:Humans; D007231:Infant, Newborn; D015999:Multivariate Analysis; D007752:Obstetric Labor, Premature / Q000208:ethnology*; D016017:Odds Ratio; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000208:ethnology*; D011295:Prenatal Care / Q000379:methods; D012307:Risk Factors; D044465:White People / Q000706:statistics & numerical data*; D055815:Young Adult