GES-11, a novel integron-associated GES variant in Acinetobacter baumannii.
New extended-spectrum beta-lactamase GES-11 was detected in Acinetobacter baumannii BM4674. The enzyme conferred resistance to beta-lactams, including aztreonam, and reduced susceptibility to carbapenems. The structural gene was part of a class 1 integron borne by self-transferable plasmid pIP847. GES-type beta-lactamases have not been reported previously in A. baumannii.
Moubareck
Carole
C
Institut Pasteur, Unité des Agents Antibactériens, Centre National de Référence de la Résistance aux Antibiotiques, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France.
Brémont
Sylvie
S
Conroy
Marie-Christine
MC
Courvalin
Patrice
P
Lambert
Thierry
T
D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D032023:Integrons / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D047090:beta-Lactams; D001618:beta-Lactamases; D001398:Aztreonam