Fentanyl-induced bradykinesia and rigidity after deep brain stimulation in a patient with Parkinson disease.
A 58-year-old man with advanced Parkinson disease underwent battery replacement for a deep brain stimulator and experienced severe bradykinesia and rigidity postoperatively for 36 hours. The patient was administered fentanyl as an anesthetic during the procedure and as an analgesic periodically during the day after surgery. The severe bradykinesia and rigidity persisted despite reactivation of the deep brain stimulator and immediate reinstitution of Parkinson disease medications, but resolved completely several hours after discontinuation of fentanyl.
Zesiewicz
Theresa A
TA
Parkinson's Disease and Movement Disorders Center, Department of Neurology, University of South Florida, Tampa, 33612, USA. tzesiewi@hsc.usf.edu
Hauser
Robert A
RA
Freeman
Alan
A
Sullivan
Kelly L
KL
Miller
Amber M
AM
Halim
Tariq
T
D000701:Analgesics, Opioid / Q000009:adverse effects*; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D005283:Fentanyl / Q000009:adverse effects*; D006801:Humans; D018476:Hypokinesia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000209:etiology*; D010300:Parkinson Disease / Q000628:therapy*
D000701:Analgesics, Opioid; D005283:Fentanyl