title: Slow pre-movement cortical potentials do not reflect individual response to therapy in writer's cramp.
abstract: OBJECTIVE
  To investigate whether movement-related cortical potentials (MRCP) provide a physiological correlate that indicates the response to treatment in patients with writer's cramp.
  
  
  METHODS
  In 21 patients with writer's cramp, who underwent 4 weeks of limb immobilization followed by re-training for 8 weeks, we recorded MRCPs preceding a self-initiated brisk finger abduction movement. MRCP measurements of pre-movement activity were performed at baseline, after the end of immobilization and four and 8 weeks of re-training. We examined 12 controls, who received no intervention, twice 4 weeks apart.
  
  
  RESULTS
  Patients benefited from the therapeutical intervention (Zeuner et al., 2008). They showed no abnormalities of the MRCPs at baseline. In controls, MRCPs did not significantly change after 4 weeks. In patients, immobilization and re-training had no effect on MRCPs. There was no correlation between the severity of dystonic symptoms or the individual treatment response and MRCPs.
  
  
  CONCLUSIONS
  MRCPs are stable measures for interventional studies. However, they do not reflect clinical severity of dystonic symptoms or improvement after therapeutic interventions.
  
  
  CONCLUSIONS
  This is the first study to investigate MRCPs in a large cohort of patients with writer's cramp compared to a control group at different time points. These potentials do not reflect the motor control disorder in patients with writer's cramp.
authors.affiliation: Department of Neurology, Christian-Albrechts-University Kiel, Arnold Heller Strasse 3, Haus 41, 24105 Kiel, Germany. k.zeuner@neurologie.uni-kiel.de
authors.forename: K E
authors.initials: KE
authors.lastname: Zeuner
authors.forename: M
authors.initials: M
authors.lastname: Peller
authors.forename: A
authors.initials: A
authors.lastname: Knutzen
authors.forename: S
authors.initials: S
authors.lastname: Groppa
authors.forename: I
authors.initials: I
authors.lastname: Holler
authors.forename: F
authors.initials: F
authors.lastname: Kopper
authors.forename: J
authors.initials: J
authors.lastname: Raethjen
authors.forename: D
authors.initials: D
authors.lastname: Dressler
authors.forename: M
authors.initials: M
authors.lastname: Hallett
authors.forename: G
authors.initials: G
authors.lastname: Deuschl
authors.forename: H R
authors.initials: HR
authors.lastname: Siebner
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D003265:Contingent Negative Variation / Q000502:physiology*; D004421:Dystonia / Q000503:physiopathology* / Q000628:therapy*; D020821:Dystonic Disorders / Q000503:physiopathology* / Q000628:therapy*; D004569:Electroencephalography; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009068:Movement / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D012149:Restraint, Physical / Q000379:methods / Q000502:physiology