title: Chronic fatigue syndrome.
abstract: BACKGROUND
  Chronic fatigue syndrome (CFS) affects between 0.006% and 3% of the population depending on the criteria of definition used, with women being at higher risk than men.
  
  
  METHODS
  We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for chronic fatigue syndrome? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2007 (BMJ Clinical evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
  
  
  RESULTS
  We found 45 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
  
  
  CONCLUSIONS
  In this systematic review we present information relating to the effectiveness and safety of the following interventions: antidepressants, cognitive behavioural therapy (CBT), corticosteroids, dietary supplements, evening primrose oil, galantamine, graded exercise therapy, homeopathy, immunotherapy, intramuscular magnesium, oral nicotinamide adenine dinucleotide, and prolonged rest.
authors.affiliation: Imperial College, St Mary's Hospital, London, UK.
authors.forename: Steven F
authors.initials: SF
authors.lastname: Reid
authors.forename: Trudie
authors.initials: T
authors.lastname: Chalder
authors.forename: Anthony
authors.initials: A
authors.lastname: Cleare
authors.forename: Matthew
authors.initials: M
authors.lastname: Hotopf
authors.forename: Simon
authors.initials: S
authors.lastname: Wessely
mesh_terms: D005081:Exercise Therapy; D015673:Fatigue Syndrome, Chronic / Q000188:drug therapy; D006705:Homeopathy; D006801:Humans; D015995:Prevalence; D012146:Rest; D018434:Sickness Impact Profile; D014486:United States Food and Drug Administration