9,11-Secosterols with antiproliferative activity from the gorgonian Eunicella cavolini.
Four new 9,11-secosterols (2, 4-6), along with two previously reported ones (1, 3) were isolated from the organic extract of the gorgonian Eunicella cavolini. The structures and relative configurations of the isolated natural products were established on the basis of detailed NMR spectroscopic analysis. Metabolites 1 and 2 were found to strongly inhibit the growth of LNCaP human prostate adenocarcinoma cells and the estrogen-dependent growth of MCF-7 human breast adenocarcinoma cells.
Ioannou
Efstathia
E
Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens, Greece.
Abdel-Razik
Ayman F
AF
Alexi
Xanthippi
X
Vagias
Constantinos
C
Alexis
Michael N
MN
Roussis
Vassilios
V
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
D018931:Antineoplastic Agents, Hormonal; D004967:Estrogens; D013261:Sterols