Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1).
Ceramide-1-phosphate (C1P) is known as a second messenger regulating a multitude of processes including cell growth, apoptosis and inflammation. Exciting recent findings now suggest that C1P can stimulate macrophages migration in an extra-cellular manner via a G protein-coupled receptor (GPCR). Interestingly, a synthetic C1P analog, named phospho-ceramide analogue-1 (PCERA-1), was recently described as a potent in-vivo anti-inflammatory agent, and was suggested to act on macrophages in an extra-cellular manner via a GPCR. Here we summarize and compare the receptor-mediated as well as receptor-independent activities of natural C1P and its synthetic analog. We also provide experimental data in support of distinct C1P and PCERA-1 receptors.
Levi
Maya
M
Department of Biochemistry, Life Sciences Institute, Tel-Aviv University, Tel-Aviv, Israel.
Meijler
Michael M
MM
Gómez-Muñoz
Antonio
A
Zor
Tsaffrir
T
D000818:Animals; D002465:Cell Movement / Q000276:immunology; D002518:Ceramides / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology
D002518:Ceramides; C541330:PCERA-1; C065576:ceramide 1-phosphate