Interlaboratory comparison of the Doumas bilirubin reference method.
OBJECTIVE
To assess the performance of the Doumas bilirubin reference method.


METHODS
Ring trails using pooled patient specimens, a calibrator and human sera enriched with unconjugated bilirubin were analyzed in five laboratories using the Doumas bilirubin reference method.


RESULTS
The coefficient of variation for the linear measurement range between laboratories ranged from 1-3%.


CONCLUSIONS
The Doumas bilirubin reference method is robust and reproducible. Bilirubin results using this method may be used in the development of more accurate and reliable calibrators.
Lo
Stanley F
SF
Department of Pathology, Medical College of Wisconsin, Milwaukee, USA. slo@mcw.edu
Kytzia
Hans-Joachim
HJ
Schumann
Gerhard
G
Swartzentruber
Melanie
M
Vader
Huib L
HL
Weber
Friederike
F
Doumas
Basil T
BT
D001663:Bilirubin / Q000097:blood*; D019411:Clinical Laboratory Techniques / Q000379:methods / Q000592:standards; D005069:Evaluation Studies as Topic; D006801:Humans; D012015:Reference Standards; D012016:Reference Values
D001663:Bilirubin