title: [The expression of Galectin-3 and VEGF in laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression of galectin-3 and VEGF in laryngeal squamous cell carcinoma (LSCC) tissue and to analyze its role in differentiation, growth and metastasis of the tumor.
  
  
  METHODS
  The expression of galectin-3 and VEGF were detected with SP immunohistochemistry staining and western blot in twenty-nine specimens of LSCC and eighteen specimens of laryngeal benign lesion.
  
  
  RESULTS
  The expression of galectin-3 (89.7%) and VEGF (86.2%) in LSCC were remarkably higher than that in normal control tissue (P<0.05), and the expression of galectin-3 (89.7%) and VEGF (86.2%) in higher histodifferentiation specimens were higher than that in lower histodifferentiation specimens (P<0.05). Moreover, the expression level of galectin-3 and VEGF was detected a statistical positive correlation (r=0.423, P<0.05) in LSCC.
  
  
  CONCLUSIONS
  The high level expression of galectin-3 and VEGF in LSCC could play an important role in tumorous histodifferentiation and metastasis.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China. konghong@jlu.edu.cn
authors.forename: Hong
authors.initials: H
authors.lastname: Kong
authors.forename: Junsheng
authors.initials: J
authors.lastname: Cui
authors.forename: Lianyou
authors.initials: L
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Dong
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D037502:Galectin 3 / Q000378:metabolism*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D037502:Galectin 3; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A