title: Motor cortical organization in an adult with hemimegalencephaly and late onset epilepsy.
abstract: Hemimegalencephaly is a rare brain malformation whose physiology is largely obscure. In a single patient, we studied motor cortex using several transcranial magnetic stimulation variables testing cortical excitability, and mapping motor area. The megalencephalic hemisphere showed an enlargement of cortical motor map with abnormal axonal orientation and an excess spread of corticospinal excitation, associated with multiple defects of cortical inhibition. TMS gave new information on the anatomic/functional features and epileptogenesis in this complex and physiologically obscure syndrome.
authors.affiliation: Department of Medical Sciences, Section of Neurology, Università del Piemonte Orientale A. Avogadro, Novara, Italy. c civardi@yahoo.com
authors.forename: Carlo
authors.initials: C
authors.lastname: Civardi
authors.forename: Roberta
authors.initials: R
authors.lastname: Vicentini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Collini
authors.forename: Cristina
authors.initials: C
authors.lastname: Boccagni
authors.forename: Roberto
authors.initials: R
authors.lastname: Cantello
authors.forename: Francesco
authors.initials: F
authors.lastname: Monaco
mesh_terms: D000328:Adult; D001931:Brain Mapping; D004558:Electric Stimulation; D004827:Epilepsy / Q000150:complications / Q000473:pathology*; D019054:Evoked Potentials, Motor / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications / Q000473:pathology*; D009044:Motor Cortex / Q000473:pathology* / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods