Dexamethasone decreases the transmesothelial electrical resistance of the parietal and visceral pleura.
The effect of dexamethasone on the transmesothelial electrical resistance (R(TM)) of sheep pleura was investigated by Ussing chamber experiments. Our results show that dexamethasone decreases the R(TM) of sheep pleurae, in part by stimulation of glucocorticoid receptors. This finding may be of importance in regard to the faster resolution of corticosteroid-treated pleural effusions.
Zarogiannis
Sotirios
S
Department of Physiology, University of Thessaly Medical School, Mezourlo Hill, 41110 Larissa, Greece.
Deligiorgi
Triantafyllia
T
Stefanidis
Ioannis
I
Liakopoulos
Vassilios
V
Gourgoulianis
Konstantinos
K
Molyvdas
Paschalis Adam
PA
Hatzoglou
Chrissi
C
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D017097:Electric Impedance; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010994:Pleura / Q000187:drug effects* / Q000502:physiology*; D010996:Pleural Effusion / Q000188:drug therapy; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000502:physiology; D012756:Sheep
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone