title: Detection of blaSHV, blaTEM and blaCTX-M antibiotic resistance genes in randomly selected bacterial pathogens from the Steve Biko Academic Hospital.
abstract: Extended-spectrum beta-lactamases (ESBLs) are considered to be one of the most important antibiotic resistance mechanisms. This study reported the ESBL-producing genes in 53 randomly selected clinical bacterial isolates from the Steve Biko Academic Hospital. The presence of the bla(SHV), bla(TEM) and bla(CTX-M) genes was determined, and the overall prevalence of these genes detected in this study was 87% (46/53) in comparison with the literature; these results were higher when compared with 33% for Escherichia coli in Europe and 0.8% in Denmark for similar pathogens. These research findings indicated that it is crucial to routinely monitor the prevalence of these resistance genes.
authors.affiliation: Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria/NHLS, Pretoria 0001, South Africa. marthie.ehlers@up.ac.za
authors.forename: Marthie M
authors.initials: MM
authors.lastname: Ehlers
authors.forename: Chrisna
authors.initials: C
authors.lastname: Veldsman
authors.forename: Eddy P
authors.initials: EP
authors.lastname: Makgotlho
authors.forename: Michael G
authors.initials: MG
authors.lastname: Dove
authors.forename: Anwar A
authors.initials: AA
authors.lastname: Hoosen
authors.forename: Marleen M
authors.initials: MM
authors.lastname: Kock
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D006761:Hospitals; D006801:Humans; D013019:South Africa; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases