Nucleophilic heterocyclic carbene catalyzed annulation of enals to chalcones in methanol: a stereoselective synthesis of highly functionalized cyclopentanes.
Homoenolates generated from enals by nucleophilic heterocyclic carbene (NHC) catalysis undergo annulation with chalcones in methanol to afford methyl beta-hydroxycyclopentanecarboxylates, stereoselectively. Construction of four contiguous stereocenters in a stereoselective manner is noteworthy.
Nair
Vijay
V
Organic Chemistry Section, National Institute for Interdisciplinary Science and Technology (CSIR), Trivandrum 695 019, India. Vijaynair_2001@yahoo.com
Babu
Beneesh P
BP
Vellalath
Sreekumar
S
Varghese
Vimal
V
Raveendran
Anabha E
AE
Suresh
Eringathodi
E