title: Immunogenicity and safety of diphtheria-tetanus vaccine in pre-adolescent and adolescent South Koreans.
abstract: This study was conducted to compare the immunogenicity and safety of diphtheria-tetanus (Td) vaccine between pre-adolescents aged 11-12 years and adolescents aged 13-18 years. A total of 277 subjects (132 pre-adolescents and 145 adolescents) participated. After vaccination, all subjects (100%) in both groups exhibited seroprotective antibody levels (> or =0.1I U/mL) against diphtheria or tetanus toxoids. Although local adverse events following vaccination were more frequently observed in the pre-adolescent group than in the adolescent group (p=0.006), these events resolved within 7 days. Our study shows Td vaccination at age 11-12 years to be immunogenic and tolerable.
authors.affiliation: Department of Pediatrics, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Ga Young
authors.initials: GY
authors.lastname: Kwak
authors.forename: Chan Hee
authors.initials: CH
authors.lastname: Nam
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Jae Kun
authors.initials: JK
authors.lastname: Hur
authors.forename: Kyung Yil
authors.initials: KY
authors.lastname: Lee
authors.forename: Joon Su
authors.initials: JS
authors.lastname: Park
authors.forename: Hwang Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Jin Han
authors.initials: JH
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D002648:Child; D022422:Diphtheria-Tetanus Vaccine / Q000009:adverse effects / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D014611:Vaccination
chemical_list: D022422:Diphtheria-Tetanus Vaccine