title: [Antioxidant status and restenosis after stenting of coronary arteries].
abstract: OBJECTIVE
  To investigate possibility of effect of antioxidant status on severity of restenosis of coronary arteries after transluminal coronary angioplasty with stenting.
  
  
  METHODS
  Men with ischemic heart disease and coronary angiography performed in 6 months after coronary artery stenting with bare stents were included in this study. Coronary angiograms were subjected to quantitative computer analysis. Samples of venous blood were obtained before control angiography. We assessed duration of lag phase of copper induced free radical oxidation of low density lipoproteins (LDL), and measured level of lipoperoxides in LDL, content of malone dialdehyde (MDA) in LDL, activity of superoxide dismutase (SOD), glutathione peroxidase (GP), and erythrocyte catalase.
  
  
  RESULTS
  We revealed positive correlations of lag phase duration and activity of GP with minimal artery diameter 6 months after stenting (r=0.41, p < 0.002 and r=0.24, p < 0.05, respectively), of lipoperoxide level in LDL and MDA content in LDL with degree of stenosis (r=0.32, p < 0.009, and r=0.37, p < 0002, respectively). We also found negative correlations between lag phase duration and GP activity with degree of restenosis (r= - 0.38, p < 0.04, and r= - 0.39, p < 0.001, respectively), level of lipoperoxides in LDL and MDA content in LDL with artery minimal diameter (r= - 0.33, p < 0.007, and r=0.32, p < 0.008, respectively).
  
  
  CONCLUSIONS
  Our study confirms possibility of influence of antioxidant status on degree of coronary artery restenosis in patients after coronary artery stenting.
authors.forename: A I
authors.initials: AI
authors.lastname: Kaminnyĭ
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Shuvalova
authors.forename: V Z
authors.initials: VZ
authors.lastname: Lankin
authors.forename: G F
authors.initials: GF
authors.lastname: Piksina
authors.forename: R O
authors.initials: RO
authors.lastname: Shirokov
authors.forename: A N
authors.initials: AN
authors.lastname: Samko
authors.forename: V V
authors.initials: VV
authors.lastname: Kukharchuk
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D000975:Antioxidants / Q000378:metabolism*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D011379:Prognosis; D015607:Stents
chemical_list: D000975:Antioxidants