title: Functionalized BF(2) Chelated Azadipyrromethene Dyes.
abstract: Fluorescent molecules that emit in the near infra-red are potentially useful as probes for biotechnology. A relatively under-explored design for probes of this type are the aza-BODIPY dyes; this study was performed to enhance our understanding of these materials and ways in which they may be used in dye cassette systems. Thus, the aza-BODIPY dyes 1a - g were prepared. An advanced intermediate towards an eighth compound in the series, 6h, was made but it could not be complexed with boron effectively to give 1h. Spectroscopic properties of these compounds were recorded, and correlations between substituent effects, UV absorbance, fluorescence emissions, and quantum yields were made. Compound 1a was coupled with a fluorescein-alkyne derivative to give the energy transfer cassettes 2 and 3. Both these compounds gave poor energy transfer, and the possible reasons for this were discussed.
authors.affiliation: Department of Chemistry, Texas A & M University, Box 30012, College Station, TX 77841-3012.
authors.forename: Aurore
authors.initials: A
authors.lastname: Loudet
authors.forename: Rakeshwar
authors.initials: R
authors.lastname: Bandichhor
authors.forename: Liangxing
authors.initials: L
authors.lastname: Wu
authors.forename: Kevin
authors.initials: K
authors.lastname: Burgess