Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism.
Muscleblind-like 2 (Mbnl2) is a zinc finger protein first identified in Drosophila. It appears to be essential for photoreceptor development and to be involved in RNA splicing. Here we report that Mbnl2 is strongly expressed in the rat pineal gland. The abundance of pineal Mbnl2 transcripts follows a marked circadian rhythm with peak levels approximately sevenfold higher at night than day levels. Mbnl2 protein exhibits a similar rhythm. In vitro studies indicate that the abundance of Mbnl2 transcripts and protein are controlled by an adrenergic/cAMP mechanism.
Kim
Jong-So
JS
Program on Developmental Endocrinology and Genetics, Section on Neuroendocrinology, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Coon
Steven L
SL
Weller
Joan L
JL
Blackshaw
Seth
S
Rath
Martin F
MF
Møller
Morten
M
Klein
David C
DC
D000320:Adrenergic Fibers / Q000737:chemistry / Q000502:physiology; D000818:Animals; D002460:Cell Line; D002940:Circadian Rhythm / Q000235:genetics; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000502:physiology; D009924:Organ Culture Techniques; D010870:Pineal Gland / Q000502:physiology*; D016601:RNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
C529512:Mbnl2 protein, mouse; D016601:RNA-Binding Proteins; D000242:Cyclic AMP