Modification of blood antioxidant status and lipid profile in response to high-intensity endurance exercise after low doses of omega-3 polyunsaturated fatty acids supplementation in healthy volunteers.
We investigated whether endurance exercise might modify the blood antioxidant status and lipid profile after omega-3 fatty acid supplementation. Two groups of healthy, fit males performed 1 h of exercise with a constant work load corresponding to 60% of their individual VO(2 max) and various pedaling rates (45 min-60 rev/min followed by a maximal rate), before and after receiving, over 6 weeks, omega-3 fatty acids in a daily dose of 1.3 g or placebo. The resting concentration of triglycerides decreased after omega-3 fatty acid consumption. In response to endurance exercise, the superoxide dismutase activity markedly decreased in sedentary control subjects. This effect was partially protected by omega-3 fatty acid consumption. Supplementation tended to increase atalase activity in response to exercise, and this activity was significantly higher after 1 h of recovery. We conclude that the beneficial effect of omega-3 fatty acid supplementation during endurance exercise may be due to the activation of the superoxide dismutase and catalase pathways.
Poprzecki
Stanisław
S
Department of Biochemistry, Academy of Physical Education in Katowice, Katowice, Poland.
Zajac
Adam
A
Chalimoniuk
Malgorzata
M
Waskiewicz
Zbigniew
Z
Langfort
Józef
J
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001642:Bicycling / Q000502:physiology; D002374:Catalase / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010807:Physical Endurance / Q000502:physiology*; D012146:Rest / Q000502:physiology; D013482:Superoxide Dismutase / Q000378:metabolism; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
D000975:Antioxidants; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D014280:Triglycerides; D002374:Catalase; D013482:Superoxide Dismutase