Preparation of fenofibrate nanosuspension and study of its pharmacokinetic behavior in rats.
BACKGROUND
In this study, nanosuspension was prepared to improve the dissolution rate and bioavailability of lipophilic fenofibrate.


METHODS
Melt emulsification method combined with high-pressure homogenization was adapted, and mixture of poloxamer188 and PVP K30 were selected as surfactants. This method consumed less energy and was more efficient than traditional homogenization of drug solid particles suspension directly.


RESULTS
The dissolution rate of fenofibrate nanosuspension was increased obviously, and the product was evaluated by pharmacokinetic characteristic in rats. The AUC(0-36 h) and C(max) of nanosuspensions were increased when compared with the reference formulations. No significant differences were found between the two nanosuspensions A and B, of which the mean particle sizes were 356 and 194 nm, respectively. Therefore, nanosuspensions may be a suitable delivery system to improve the bioavailability of those drugs with poor water solubility.
Li
XueMing
X
College of Life Science and Pharmaceutics, Nanjing University of Technology, Nanjing, China. xuemingli@njut.edu.cn
Gu
Li
L
Xu
Yuanlong
Y
Wang
Yonglu
Y
D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D011345:Fenofibrate / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013535:Suspensions
D013535:Suspensions; D011345:Fenofibrate