title: [Safety and efficacy of intraoperative 5-fluorouracil infiltration in pterygium treatment].
abstract: OBJECTIVE
  To investigate the safety and efficacy of intraoperative infiltration of 5-fluorouracil (5-FU) as an adjuvant drug in pterygium treatment.
  
  
  METHODS
  Of 125 consecutive patients, 125 eyes with primary and recurrent pterygium underwent pterygium excision with intraoperative 5-FU (25 mg/mL) infiltration. The superior and inferior conjunctiva was approximated to cover the scleral bed and 0.2 mL 5-FU was injected at the end of the surgical procedure. The gender, occupation, pterygium characteristics and the follow-up at 7, 21, 60 e 180 days after surgery were evaluated and the data were statistically analyzed.
  
  
  RESULTS
  With follow-up of 180 days the patients had no serious complications observed during or after surgery. The relapse rate was 35.8% and occurred in primary (35.7%) and recurrent (36.4%) lesions with no statistical difference.
  
  
  CONCLUSIONS
  This study suggests that intraoperative infiltration of 5-FU is safe. However the high recurrence rate indicated that other studies would be necessary to show the concentration/dose to better prevent it.
authors.affiliation: Departamento de Oftalmologia/Otorrinolaringologia/Cabeça e Pescoço, Universidade Estadual Paulista, Botucatu, SP, Brasil. sartioli@fmb.unesp.br
authors.forename: Vanessa Grandi
authors.initials: VG
authors.lastname: Valezi
authors.forename: Silvana Artioli
authors.initials: SA
authors.lastname: Schellini
authors.forename: Magda Massae Hata
authors.initials: MM
authors.lastname: Viveiros
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Padovani
mesh_terms: D000328:Adult; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011625:Pterygium / Q000188:drug therapy / Q000601:surgery*; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D005472:Fluorouracil