Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm.
Fluorescently tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm.
Stewart
Philip S
PS
Center for Biofilm Engineering, Department of Chemical and Biological Engineering, Montana State University, Bozeman, MT 59717-3980, USA. phil_s@biofilm.montana.edu
Davison
William M
WM
Steenbergen
Judith N
JN
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D018441:Biofilms / Q000187:drug effects; D017576:Daptomycin / Q000493:pharmacokinetics*; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D017576:Daptomycin