The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes.
Uncoupling protein 1 (UCP1), a 32-kDa protein located in the inner mitochondrial membrane, is abundant in brown adipose tissue, as a proton transporter in mitochondria inner membrane which uncouples oxidative metabolism from ATP synthesis and dissipates energy through the heat. UCP1 has been reported to play important roles for energy homeostasis in rodents and neonate of larger mammals including human. Recently, numerous candidate genes were searched to determine the genetic factors implicated in the pathogenesis of obesity, related metabolic disorders and diabetes. UCP-1, which plays a major role in thermogenesis, was suggested to be one of the candidates. This review summarizes data supporting the existence of brown adipocytes and the role of UCP1 in energy dissipation in adult humans, and the genetic variety association with the fat metabolism, obesity and diabetes.
Jia
Jun-jing
JJ
Yunnan Provincial Laboratory of Animal Nutrition and Feed Science, Yunnan Agricultural University, Yunnan Province, People's Republic of China. junjingli2003@yahoo.com.cn
Tian
Yun-bo
YB
Cao
Zhen-hui
ZH
Tao
Lin-li
LL
Zhang
Xi
X
Gao
Si-zhen
SZ
Ge
Chang-rong
CR
Lin
Qiu-Ye
QY
Jois
M
M
D052437:Adipocytes, Brown / Q000378:metabolism*; D000328:Adult; D003920:Diabetes Mellitus / Q000235:genetics*; D040461:Gene Components; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D051336:Mitochondrial Membranes / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D022722:Thermogenesis / Q000235:genetics*; D000071256:Uncoupling Protein 1
D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1