Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.
OBJECTIVE
IgA nephropathy is one of the most common glomerular diseases in children. The aim of this study was to investigate the clinical and pathologic efficacy of methylprednisolone and cyclophosphamide in the treatment of primary pediatric IgA nephropathy.


METHODS
11 patients with renal-biopsy-diagnosed Grade IV IgA nephropathy were treated with methylprednisolone and cyclophosphamide. Pathological changes were evaluated by post-treatment renal biopsies.


RESULTS
At follow-up (18 - 60 months post-treatment), 6 patients were in complete remission. For the remaining 5, treatment was rated "markedly effective." Renal biopsies showed less mesangial proliferation, significantly decreased crescent formation, reduced segmental sclerosis, and significantly reduced mesangial IgA deposition.


CONCLUSIONS
Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.
Jiang
X-Y
XY
Department of Pediatrics, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China. xyjiang-3208@163.com
Mo
Y
Y
Sun
L-Z
LZ
Yue
Z-H
ZH
Chen
S-M
SM
Wu
W
W
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001706:Biopsy; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006417:Hematuria / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007070:Immunoglobulin A / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D011507:Proteinuria / Q000150:complications / Q000188:drug therapy; D020551:Pulse Therapy, Drug / Q000379:methods; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D007070:Immunoglobulin A; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008775:Methylprednisolone