Adipose tissue at the crossroads in the development of the metabolic syndrome, inflammation and atherosclerosis.
The authors analyze insulin resistance, the metabolic syndrome and endothelial dysfunction as consequence of a common antecedent, a low grade inflammation, indicating that in obesity there is a chronically activated inflammatory state of the adipose tissue. Furthermore, the inflammatory signaling is discussed according to the adipose tissue depot, visceral or subcutaneous.
Wajchenberg
Bernardo Léo
BL
Serviço de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Arnaldo 455, São Paulo, SP, Brazil. bernarwaj@globo.com
Nery
Marcia
M
Cunha
Maria Rosaria
MR
Silva
Maria Elizabeth Rossi da
ME
D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D050152:Intra-Abdominal Fat / Q000378:metabolism; D024821:Metabolic Syndrome / Q000209:etiology / Q000503:physiopathology*; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D015434:Panniculitis / Q000378:metabolism / Q000503:physiopathology*; D050151:Subcutaneous Fat / Q000378:metabolism
D054392:Adipokines; D018836:Inflammation Mediators