From metal binding to nanoparticle formation: monitoring biomimetic iron oxide synthesis within protein cages using mass spectrometry.
Mass measurements of metal-mineralized protein cages allowed quantitative examination of the effects of metal-ion concentration on the final nanoparticle size. Modeling using a kinetic master equation suggests that particle growth involves both a binding phase and a growth phase (see picture; I: relative abundance; LiDps: a DNA binding protein; (n)Fe: number of Fe atoms).
Kang
Sebyung
S
Department of Chemistry and Biochemistry, Center for BioInspired Nanomaterials, Montana State University, Bozeman, MT 59717, USA.
Jolley
Craig C
CC
Liepold
Lars O
LO
Young
Mark
M
Douglas
Trevor
T
D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D005290:Ferric Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013058:Mass Spectrometry; D008670:Metals / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*
D004268:DNA-Binding Proteins; D005290:Ferric Compounds; D008670:Metals; C000499:ferric oxide