Functional mapping of the motor cortex of the rat using transdural electrical stimulation.
Motor cortex stimulation oriented by functional cortical mapping is used mainly for treating otherwise intractable neurological disorders, however, its mechanism of action remains elusive. Herein, we present a new method for functional mapping of the rat motor cortex using non-invasive transdural electrical stimulation. This method allows a non-invasive mapping of the surface of the neocortex providing a differentiation of representative motor areas. This study may facilitate further investigation about the mechanisms mediating the effects of electrical stimulation, possibly benefiting patients who do not respond to this neuromodulation therapy.
Fonoff
Erich Talamoni
ET
Teaching and Research Institute, Hospital Sírio-Libanês, São Paulo, SP, Brazil. fonoffet@usp.br
Pereira
Jose Francisco
JF
Camargo
Leonardo Valente
LV
Dale
Camila Squarzoni
CS
Pagano
Rosana Lima
RL
Ballester
Gerson
G
Teixeira
Manoel Jacobsen
MJ
D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D004558:Electric Stimulation / Q000379:methods*; D019054:Evoked Potentials, Motor; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009044:Motor Cortex / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar