Apolipoprotein E genotype in patients with cerebrovascular diseases and its effect on the disease outcome.
A total of 100 hospitalized stroke patients and 30 healthy controls were included in a study aiming to determine the predictive role of ApoE genotype polymorphism for stroke outcome in the Turkish population. The most frequent ApoE genotype was epsilon3/3 reflecting Asian population polymorphic distribution. ApoE polymorphism in the Eastern Turkish population was found to be independent of stroke type, OSCP subtypes of infarction, localization of hemorrhage, severity of carotid artery stenosis, and resultant stroke outcome. Distinct polymorphic results in populations from nearby regions suggest a multifactorial pathogenesis and presence of very complex genetic factors in the development of stroke and stroke outcome.
Tamam
Yusuf
Y
Department of Neurology, Medical School Dicle University, Diyarbakir, Turkey. yusuta@yahoo.com
Tasdemir
Nebahat
N
Toprak
Recep
R
Tamam
Banu
B
Iltumur
Kenan
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D001925:Brain Damage, Chronic / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D020127:Recovery of Function; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
D001057:Apolipoproteins E; D008077:Lipoproteins, LDL