title: Angiotensin-converting enzyme and adducin-1 polymorphisms in women with preeclampsia and gestational hypertension.
abstract: The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the Adducin-1 (ADD1) G460W nonsense single nucleotide polymorphism (SNP) have previously been associated to hypertension, whereas their association with preeclampsia (PE) and gestational hypertension (GH) is still controversial. We genotyped ACE I/D, ADD1 G460W, and ADD1 S586C polymorphisms in 672 unrelated pregnant women: 204 PE (81/204 mild PE), 56 GH, and 412 controls, evaluating both their single and combined effects on these pathologies. The genotype combination of the 3 polymorphisms was not statistically different in cases versus controls, nor were ACE and ADD1 polymorphisms in GH. Nevertheless, the distribution of ACE genotypes was different in PE. This was confirmed in mild PE, whereas no significance was found in severe PE. This could suggest that different factors may lead to mild and severe PE, with ACE polymorphism playing a more important role in the mild form.
authors.affiliation: Unit of Obstetrics and Gynecology, Department of Clinical Sciences L. Sacco, University of Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Mandò
authors.forename: Patrizio
authors.initials: P
authors.lastname: Antonazzo
authors.forename: Silvia
authors.initials: S
authors.lastname: Tabano
authors.forename: Susanna
authors.initials: S
authors.lastname: Zanutto
authors.forename: Paola
authors.initials: P
authors.lastname: Pileri
authors.forename: Edgardo
authors.initials: E
authors.lastname: Somigliana
authors.forename: Francesca
authors.initials: F
authors.lastname: Colleoni
authors.forename: Anna
authors.initials: A
authors.lastname: Martinelli
authors.forename: Anna
authors.initials: A
authors.lastname: Zolin
authors.forename: Chiara
authors.initials: C
authors.lastname: Benedetto
authors.forename: Luca
authors.initials: L
authors.lastname: Marozio
authors.forename: Isabella
authors.initials: I
authors.lastname: Neri
authors.forename: Fabio
authors.initials: F
authors.lastname: Facchinetti
authors.forename: Monica
authors.initials: M
authors.lastname: Miozzo
authors.forename: Irene
authors.initials: I
authors.lastname: Cetin
mesh_terms: D000328:Adult; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000235:genetics* / Q000401:mortality*; D007231:Infant, Newborn; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics* / Q000401:mortality*; D011247:Pregnancy; D012307:Risk Factors; D012720:Severity of Illness Index; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; D007703:Peptidyl-Dipeptidase A; D000099291:Adducins