Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene.
Mixed-lineage leukemia (MLL) rearrangements are commonly observed in childhood acute lymphoblastic and myeloid leukemia, as well as therapy-related leukemia. However, the occurrence of MLL rearrangements in acute megakaryoblastic leukemia (AMKL) is very rare. We report a pediatric case of AMKL with the MLL-AF4 fusion transcript. MLL-AF4 is derived from t(4;11)(q21:q23) and occurs exclusively in B-cell lineage leukemia. To our knowledge, MLL-AF4 as well as t(4;11)(q21:q23) has not been reported in adult and childhood AMKL. Thus, our case provides new insight into the molecular mechanisms of MLL-AF4-associated leukemia.
Takita
Junko
J
Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo, Japan. jtakita-tky@umin.ac.jp
Motomura
Ai
A
Koh
Katsuyoshi
K
Ida
Kohmei
K
Taki
Tomohiko
T
Hayashi
Yasuhide
Y
Igarashi
Takashi
T
D002675:Child, Preschool; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*
C113855:MLL-AF4 fusion protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein