[Activity of systemic inflammatory reaction in patients with chronic obstructive pulmonary disease in regard to small intestinal absorption function].
OBJECTIVE
To study the effect of systemic inflammatory reaction in patients with chronic obstructive pulmonary disease (COPD) in association with absorption of the small intestine.


METHODS
Small intestinal absorption was studied in 93 COPD patients (22, 36 and 35 patients at stage I, II and III, respectively) in a clinically stable stage of the disease and in 35 healthy controls. The absorption was investigated biochemically and with application of radionuclide methods, blood concentration of TNF alpha was measured with enzyme immunoassay.


RESULTS
The small intestine of patients with moderate and severe COPD showed subnormal absorption of fats, protein, carbohydrates. With the disease progression, this disorder aggravated. The same trend was seen in relation to TNF alpha concentration. A strong direct correlation was found between a high concentration of TNF alpha and a low absorption of 131I-albumin and fatty acids, this high concentration correlated negatively with low absorption of d-xilose.


CONCLUSIONS
Relationships between inflammation severity and small intestinal absorption of fats, protein, carbohydrates in patients with moderate and severe COPD means loss of essential nutrients, primarily protein and fats. This is important in understanding of pathobiological processes of development of extrapulmonary (intestinal) manifestations in COPD patients.
Beloborodova
E I
EI
Akimova
L A
LA
Burkovskaia
B A
BA
Asanova
A V
AV
Semenenko
E V
EV
D000328:Adult; D000368:Aged; D002241:Carbohydrates / Q000502:physiology; D005223:Fats / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D002241:Carbohydrates; D005223:Fats; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha