[Interaction between Actinobacillus pleuropneumoniae RTX toxin and host--a review].
Actinobacillus pleuropneumoniae (App) is the etiological agent of porcine pleuropneumonia which causes huge economic losses to the pig industry. RTX (repeat in the structural toxin, RTX) is the main virulence-associated factor of the pathogen and, plays a dual role on the pathogen's infection and immunity. Recently research progress is updated in this paper and the necessity and techniques to initiate the pathogen-host interaction study is also raised and discussed. It is believed that the research on the interaction between host and App RTX may further elucidate the pathogen' s molecular pathogenesis.
Fan
Shengxian
S
Key laboratory of Preventive Veterinary Medicine of Hubei Province, Veterinary Medicine College, Huazhong Agricultural University, Wuhan 430070, China.
Liu
Hui
H
Chen
Yang
Y
Chen
Huanchun
H
He
Qigai
Q
D016977:Actinobacillus pleuropneumoniae / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D000818:Animals; D001427:Bacterial Toxins / Q000235:genetics / Q000276:immunology*; D054884:Host-Pathogen Interactions; D018410:Pneumonia, Bacterial / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D013553:Swine Diseases / Q000276:immunology* / Q000382:microbiology; D037521:Virulence Factors / Q000276:immunology*
D001427:Bacterial Toxins; D037521:Virulence Factors