title: Breast cancer in a male with ankylosing spondylitis treated with TNFalpha antagonists.
abstract: A 72-year-old male with a 4-year history of TNFalpha antagonist therapy (infliximab and etanercept) for ankylosing spondylitis was diagnosed with breast cancer. He had a family history of breast cancer. The low incidence and considerable severity of breast cancer in males, genetic risk factors, and potential role for TNFalpha antagonist therapy are discussed.
authors.affiliation: Service de Rhumatologie, CHU Rennes, France. la_mansouri1@yahoo.fr
authors.forename: Laila
authors.initials: L
authors.lastname: El Mansouri
authors.forename: Tifenn
authors.initials: T
authors.lastname: Couchouron
authors.forename: Guillaume
authors.initials: G
authors.lastname: Le Roux
authors.forename: Catherine
authors.initials: C
authors.lastname: Dugast
authors.forename: Françoise
authors.initials: F
authors.lastname: Burtin
authors.forename: Jean-David
authors.initials: JD
authors.lastname: Albert
authors.forename: Aleth
authors.initials: A
authors.lastname: Perdriger
authors.forename: Najia Hajjaj
authors.initials: NH
authors.lastname: Hassouni
authors.forename: Gérard
authors.initials: G
authors.lastname: Chalès
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D018567:Breast Neoplasms, Male / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D000068800:Etanercept; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects / Q000627:therapeutic use*; D000069285:Infliximab; D008297:Male; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D012307:Risk Factors; D013167:Spondylitis, Ankylosing / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D000068800:Etanercept