Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report.
The authors present a rare case of plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma in a 42-year-old woman. The lesion was surgically removed and analyzed. Histopathological examination with immunostaining revealed it to be positive for immunoglobulin G and Kappa chains, demonstrating monoclonality. However, no abnormality was observed on serum electrophoresis, skeletal survey and bone marrow aspiration. Therefore, the tumor was diagnosed solitary plasmacytoma of bone. The patient was treated with external beam radiotherapy and has remained disease free for 5 years and 6 months until 2007, when she presented a pathological fracture due to multiple myeloma. Extensive medical work-up to rule out multiple myeloma or other malignant lymphoproliferative conditions involving orbit or ocular adnexa is needed when the diagnosis of solitary plasmacytoma of bone is suspected because treatment and prognosis are very different.
Romero
Ivana Lopes
IL
Departamento de Oftalmologia, Santa Casa de Misericórdia de São Paulo, SP, Brasil. ilromero@gmail.com
Campos
Felipe Augusto Garcez de
FA
Damasceno
Renato Wendell Ferreira
RW
Vital Filho
José
J
Bison
Simone Haber Duellberg Von Faber
SH
D000328:Adult; D001706:Biopsy; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007150:Immunohistochemistry; D009101:Multiple Myeloma / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D010954:Plasmacytoma / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed
D007074:Immunoglobulin G