title: Avoidance of neuromuscular blocking agents may increase the risk of difficult tracheal intubation: a cohort study of 103,812 consecutive adult patients recorded in the Danish Anaesthesia Database.
abstract: BACKGROUND
  Previous studies indicate that avoiding neuromuscular blocking agents (NMBAs) may be a risk factor for difficult tracheal intubation (DTI). We investigated whether avoiding NMBA was associated with DTI.
  
  
  METHODS
  A cohort of 103,812 consecutive patients planned for tracheal intubation by direct laryngoscopy was retrieved from the Danish Anaesthesia Database. We used an intubation score based upon the number of attempts, change from direct laryngoscopy to a more advanced technique, or intubation by a different operator. We retrieved data on age, sex, ASA physical status classification, priority of surgery, time of surgery, previous DTI, modified Mallampati score, BMI, and the use of NMBA. Using logistic regression, we assessed whether avoiding NMBA was associated with DTI.
  
  
  RESULTS
  The frequency of DTI was 5.1 [95% confidence interval (CI): 5.0-5.3]%. In a univariate analysis, avoiding NMBA was associated with DTI, odds ratio (OR) 1.52 (95% CI: 1.43-1.61)%, P<0.0001. Using multivariate analysis, avoiding NMBA was associated with DTI, OR 1.48 (95% CI: 1.39-1.58), P<0.0001. Among patients intubated using NMBA, a multivariate analysis identified patients anaesthetized with only non-depolarizing NMBA to be more at risk for DTI than those anaesthetized with depolarizing NMBA alone.
  
  
  CONCLUSIONS
  Avoiding NMBA may increase the risk of DTI. However, confounding by indication may be a problem in this observational study and systematic reviews with meta-analysis or more randomized clinical trials are needed.
authors.affiliation: Department of Anaesthesia and Intensive Care, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark. lars_hyldborg@hotmail.com
authors.forename: L H
authors.initials: LH
authors.lastname: Lundstrøm
authors.forename: A M
authors.initials: AM
authors.lastname: Møller
authors.forename: C
authors.initials: C
authors.lastname: Rosenstock
authors.forename: G
authors.initials: G
authors.lastname: Astrup
authors.forename: M R
authors.initials: MR
authors.lastname: Gätke
authors.forename: J
authors.initials: J
authors.lastname: Wetterslev
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D015992:Body Mass Index; D015331:Cohort Studies; D000075202:Contraindications; D016208:Databases, Factual; D003718:Denmark; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents; D055815:Young Adult
chemical_list: D009466:Neuromuscular Blocking Agents