[Desmopressin effect on water-salt homeostasis and orthostatic tolerance during head-down tilting].
Effects of desmopressin, a synthetic analog of antidiuretic hormone (ADH), on water-salt metabolism and orthostatic tolerance were evaluated in human subjects during 24-hr HDT (-15 degrees). Consumption of the preparation was found to dampen losses in total body and extracellular liquids and to slow down diuresis as well as establishment of a positive water balance as compared with control series without ADH. In addition, tolerance of the standard standing test improved noticeably. To conclude, desmopressin precluded hypohydration of the tilted subjects and, consequently, prevented loss of orthostatic tolerance.
Larina
I M
IM
Noskov
V B
VB
Nichiporuk
I A
IA
Pastushkova
L Kh
LKh
Vasil'eva
G Iu
GIu
D000222:Adaptation, Physiological / Q000187:drug effects*; D000328:Adult; D050034:Antidiuretic Agents / Q000494:pharmacology*; D001826:Body Fluids / Q000187:drug effects*; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D005500:Follow-Up Studies; D018475:Head-Down Tilt / Q000502:physiology*; D006801:Humans; D008297:Male; D012016:Reference Values; D014882:Water-Electrolyte Balance / Q000187:drug effects*; D055815:Young Adult
D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin