Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder which includes both clinical and neuropathological features of a frontotemporal lobar degeneration (FTLD). In order to provide a common framework within which to discuss the characteristics of the cognitive and behavioural syndromes of ALS, and with which to conduct clinical and neuropathological research, an international research workshop on frontotemporal dementia (FTD) and ALS was held in London, Canada in June 2007. The recommendations arising from this research workshop address the requirement for a concise clinical diagnosis of the underlying motor neuron disease (Axis I), defining the cognitive and behavioural dysfunction (Axis II), describing additional non-motor manifestations (Axis III) and identifying the presence of disease modifiers (Axis IV).
Strong
Michael J
MJ
Department of Clinical Neurological Sciences, The University of Western Ontario, London, Ontario, Canada. mstrong@uwo.ca
Grace
Gloria M
GM
Freedman
Morris
M
Lomen-Hoerth
Cathy
C
Woolley
Susan
S
Goldstein
Laura H
LH
Murphy
Jennifer
J
Shoesmith
Christen
C
Rosenfeld
Jeffery
J
Leigh
P Nigel
PN
Bruijn
Lucie
L
Ince
Paul
P
Figlewicz
Denise
D
D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D032921:Consensus; D003704:Dementia / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology / Q000473:pathology