title: Interleukin-2 as a predictor of early postoperative atrial fibrillation after cardiopulmonary bypass graft (CABG).
abstract: Recently, inflammation has been considered as a risk factor of postoperative atrial fibrillation (PAF). The main purpose of this study was to estimate the connections between occurrence of PAF and cytokine release. Thirty-three patients who qualified for cardiopulmonary bypass graft (CABG) were included in the study. Blood was taken from all of them before CABG, then 3 h, 24 h, and 72 h afterwards. Cytokine (IL-6, IL-2, IL-4, IL-10, IFN-gamma, TNF-alpha) concentration was measured at every time point. Eleven patients developed atrial fibrillation after the CABG. Five of them developed PAF until 1 day post-CABG and six of them after 1 day post-CABG. Patients who developed PAF before 1 day post-CABG were characterized by a higher level of IL-2 in sera before 24 h and 72 h post-CABG compared with patients without PAF. Moreover, the PAF before 1 day post-CABG group was also characterized by the higher level of IFN-gamma and IL-10 at 24 h after intervention. Analysis of patients who developed PAF after 1 day post-CABG revealed a higher level of IL-10 and IFN-gamma at 24 h post-CABG compared with patients without PAF. In this study, we have shown for the first time a straightforward connection between IL-2 sera levels and the development of PAF shortly after CABG.
authors.affiliation: Department of Immunology, Medical University of Gdańsk, Gdańsk, Poland. lhak@amg.gda.pl
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Hak
authors.forename: Jolanta
authors.initials: J
authors.lastname: Myśliwska
authors.forename: Joanna
authors.initials: J
authors.lastname: Wieckiewicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szyndler
authors.forename: Janusz
authors.initials: J
authors.lastname: Siebert
authors.forename: Jan
authors.initials: J
authors.lastname: Rogowski
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood / Q000276:immunology*; D002315:Cardiopulmonary Bypass; D005260:Female; D006801:Humans; D007249:Inflammation; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D007376:Interleukin-2 / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000276:immunology*; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors
chemical_list: D007376:Interleukin-2; D016753:Interleukin-10; D007371:Interferon-gamma