Expression of growth hormone receptor and growth hormone in colorectal carcinoma.
OBJECTIVE
The aims of this study were to determine and compare the expression of growth hormone and growth hormone receptor in primary colorectal adenocarcinoma, regional lymph node metastases and unaffected adjacent bowel wall, and to correlate the expression of growth hormone and growth hormone receptor with clinicopathologic and survival data of the patients.


METHODS
Expression of growth hormone and growth hormone receptor were immunohistochemically analyzed in tumor, lymph node metastases and unaffected adjacent colorectal mucosa from 48 patients with colorectal carcinoma. Only the patients with long-term follow-up and known modalities of treatment and outcome were included in the study.


RESULTS
Increased expression of growth hormone receptor showed statistically significant correlation with recurrence of the disease and survival (p < 0.05), while expression of growth hormone had no significant connection with same data (p > 0.05). There was no significant difference between the expression of growth hormone and growth hormone receptor and the age, and gender of the patients, tumor diameter, and Dukes and Astler-Coller stage (p > 0.05).


CONCLUSIONS
Our data demonstrate that growth hormone receptor and growth hormone are frequently expressed in colorectal carcinomas. Patients with increased expression of growth hormone receptor had more common recurrence of the disease and shorter survival.
Jukić
Zoran
Z
Department of Surgery, Nova Gradiska General Hospital, Nova Gradiska, Croatia.
Tomas
Davor
D
Mijić
August
A
Kruslin
Bozo
B
D000230:Adenocarcinoma / Q000378:metabolism* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000628:therapy; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011986:Receptors, Somatotropin / Q000378:metabolism*; D016896:Treatment Outcome
D011986:Receptors, Somatotropin; D013006:Growth Hormone