title: A comparison of the neuroprotective efficacy of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.
abstract: The neuroprotective effects of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with cyclosarin were studied. The cyclosarin-induced neurotoxicity was monitored using a functional observational battery 24 hours after cyclosarin challenge. The results indicate that a newly developed oxime K156 is able to counteract slightly cyclosarin-induced neurotoxicity while another newly developed oxime K203 is completely ineffective in reducing cyclosarin-induced neurotoxic signs and symptoms. The neuroprotective efficacy of K156 is comparable with commonly used obidoxime and oxime HI-6. Thus, none of the newly developed oximes achieves better neuroprotective efficacy than both commonly used oximes. They are therefore not suitable replacements for antidotal treatment of acute poisonings with cyclosarin.
authors.affiliation: University of Defence, Faculty of Military Health Sciences, Department of Toxicology, Hradec Králové, Czech Republic. kassa@pmfhk.cz
authors.forename: Jirí
authors.initials: J
authors.lastname: Kassa
authors.forename: Jana Zd'árová
authors.initials: JZ
authors.lastname: Karasová
authors.forename: Sandra
authors.initials: S
authors.lastname: Tesarová
authors.forename: Kamil
authors.initials: K
authors.lastname: Kuca
authors.forename: Kamil
authors.initials: K
authors.lastname: Musílek
mesh_terms: D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity*; D008297:Male; D020258:Neurotoxicity Syndromes / Q000517:prevention & control*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010091:Oximes / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002619:Chemical Warfare Agents; D009943:Organophosphorus Compounds; D010091:Oximes; C053914:cyclohexyl methylphosphonofluoridate