title: [Expression of estrogen receptor beta in benign prostatic hyperplasia complicated by chronic prostatitis].
abstract: OBJECTIVE
  To observe the expression of estrogen receptor-beta (ERbeta) in benign prostatic hyperplasia (BPH) complicated by chronic prostatitis, and to evaluate the correlation of chronic prostatitis with ERbeta expression.
  
  
  METHODS
  Histological sections of prostate tissues were obtained from 60 BPH patients complicated by chronic prostatitis and divided into Group 1 (Grade 1), 2 (Grade 2) and 3 (Grade 3) according to the scores on the inflammation of the prostate tissues using the four-point scale designed by Irani et al. The expression of ERbeta was determined by the immunohistochemical method.
  
  
  RESULTS
  There were 24 cases (40%) in Group 1, 21 (35%) in Group 2 and 15 (25%) in Group 3, with no statistically significant differences in age and prostate volume among the three groups (P > 0.05). The expression of ERbeta was significantly decreased in Groups 2 and 3 as compared with Group 1 (P < 0.01).
  
  
  CONCLUSIONS
  The expression of ERbeta is reduced with increased scores on the inflammation of the prostate tissues in BPH patients, and the decreased ERbeta expression may be associated with the inflammatory stimulation of prostatitis.
authors.affiliation: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Yang
authors.forename: Shi-Wen
authors.initials: SW
authors.lastname: Li
authors.forename: Hang
authors.initials: H
authors.lastname: Zheng
authors.forename: Wei-Bing
authors.initials: WB
authors.lastname: Zhang
authors.forename: Wan-Li
authors.initials: WL
authors.lastname: Hu
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Zheng
mesh_terms: D000368:Aged; D002908:Chronic Disease; D047629:Estrogen Receptor beta / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D011472:Prostatitis / Q000150:complications / Q000378:metabolism* / Q000473:pathology
chemical_list: D047629:Estrogen Receptor beta