Interferon-triggered transcriptional cascades in the oligodendroglial lineage: a comparison of induction of MHC class II antigen between oligodendroglial progenitor cells and mature oligodendrocytes.
Interferon-gamma induces major histocompatibility complex class II (MHC-II) in proliferating oligodendroglial progenitor cells (OPC), but to a much lesser extent in mature oligodendrocytes. Interferon-beta has virtually no effects on MHC-II induction even in OPC. Interferon-gamma-mediated transcriptional induction of CIITA, a critical regulator of MHC-II induction, was 6-fold lower in mature oligodendrocytes than in OPC, and entirely dependent on promoter IV, suggesting that the transcriptional activity of promoter IV is down-regulated after differentiation. The distinct difference in MHC-II induction between interferon-gamma and interferon-beta is attributed to transient interferon-beta-mediated activation of STAT1-IRF1 signaling compared to the sustained interferon-gamma-mediated activation.
Itoh
Takayuki
T
Department of Neurology, University of California Davis, School of Medicine, Sacramento, CA 95817-2215, United States. takito@ucdavis.edu
Horiuchi
Makoto
M
Itoh
Aki
A
D000818:Animals; D018122:B7-1 Antigen / Q000235:genetics; D019070:Cell Lineage; D002478:Cells, Cultured; D019175:DNA Methylation; D005802:Genes, MHC Class II; D050856:Interferon Regulatory Factor-1 / Q000235:genetics / Q000502:physiology; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009687:Nuclear Proteins / Q000235:genetics; D009836:Oligodendroglia / Q000276:immunology*; D013234:Stem Cells / Q000276:immunology*; D015534:Trans-Activators / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects
D018122:B7-1 Antigen; D050856:Interferon Regulatory Factor-1; C494258:Irf1 protein, mouse; C083728:MHC class II transactivator protein; D009687:Nuclear Proteins; D015534:Trans-Activators; D007372:Interferons