Pushing single-gene genetic analysis up a Notch.
Genetic screens in Drosophila have come a long way since the pioneering work of Nüsslein-Volhard and Wieschaus. A recent paper by Mummery-Widmer et al. illustrates the use of genome-wide RNAi-based reverse genetic screens in vivo and systems biology approaches to identify new components of the Notch signaling pathway.
Hafen
Ernst
E
Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland. ehafen@ethz.ch
D000818:Animals; D005820:Genetic Testing / Q000379:methods*; D055106:Genome-Wide Association Study; D034622:RNA Interference; D051880:Receptors, Notch / Q000235:genetics*; D015398:Signal Transduction; D049490:Systems Biology / Q000379:methods
D051880:Receptors, Notch