[Effect of volatile oil from nutmeg on liver microsomal cytochrome P450 in mice].
OBJECTIVE
To study the effect of the volatile oil from nutmeg on liver microsomal cytochrome P450 in mice.


METHODS
Mice were administered the volatile oil from nutmeg at 0.4, 0.8 and 1.2 mg x g(-1), respectively, twice a day for 10 days. And then, the contents of liver microsomal cytochrome P450 (CYP), cytochrome b5 (Cytb5), MDA and GST in serum were examined by UV chromatography method.


RESULTS
The contents of liver CYP, Cytb5 and GST in serum were increased significantly (P < 0.01) and the contents of MDA was reduced significantly (P < 0.01).


CONCLUSIONS
The volatile oil from nutmeg showed induction effect on the hepatic microsomal CYP in mice.
Zhao
Runying
R
Dept of Pharmacology, Shenyang Medical College, Shenyang 110034, China. zhaorunying@sohu.com
Wang
Wei
W
Zhao
Lini
L
Li
Zhao
Z
Wang
Junping
J
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D026323:Myristica / Q000737:chemistry*; D009822:Oils, Volatile / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D010938:Plant Oils; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System