Regio- and stereoselective generation of alkenylindium compounds from indium tribromide, alkynes, and ketene silyl acetals.
InBr(3) promotes the addition of ketene silyl acetals to monosubstituted alkynes to afford 2,2-disubstituted alkenylindium compounds in high regio- and stereoselectivity (see scheme). In addition, the alkenylindium derivatives have been subsequently coupled with iodobenzene in the presence of a palladium catalyst.
Nishimoto
Yoshihiro
Y
Department of Applied Chemistry, Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, 2-1, Yamada-oka, Suita, Osaka, Japan.
Moritoh
Ryosuke
R
Yasuda
Makoto
M
Baba
Akio
A