Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice.
We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.
Lee
Ki Yong
KY
Seoul National University, Seoul, 151-742, Korea.
Sung
Sang Hyun
SH
Kim
Seung Hyun
SH
Jang
Young Pyo
YP
Oh
Tae Hwan
TH
Kim
Young Choong
YC
D000110:Acetylcholinesterase / Q000378:metabolism; D000284:Administration, Oral; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D029768:Cornus / Q000737:chemistry*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D039823:Iridoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D018697:Nootropic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D012601:Scopolamine; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D039823:Iridoids; D018697:Nootropic Agents; D012601:Scopolamine; D000110:Acetylcholinesterase; C059516:loganin