title: Pseudo-replication of [GADV]-proteins and origin of life.
abstract: The RNA world hypothesis on the origin of life is generally considered as the key to solve the "chicken and egg dilemma" concerning the evolution of genes and proteins as observed in the modern organisms. This hypothesis, however, contains several serious weak points. We have a counterproposal called [GADV]-protein world hypothesis, abbreviated as GADV hypothesis, in which we have suggested that life originated from a [GADV]-protein world, which comprised proteins composed of four amino acids: Gly [G], Ala [A], Asp [D], and Val [V]. A new concept "pseudo-replication" is crucial for the description of the emergence of life. The new hypothesis not only plausibly explains how life originated from the initial chaotic protein world, but also how genes, genetic code, and proteins co-evolved.
authors.affiliation: Narasaho College, Rokuyaon-cho 806, Nara, Nara 630-8566, Japan Fellow of the International Institute for Advanced Studies, Japan, and Emeritus Professor, Department of Chemistry, Nara Women's University, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Ikehara
mesh_terms: D000409:Alanine / Q000378:metabolism; D005815:Genetic Code; D018698:Glutamic Acid / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D008957:Models, Genetic; D000069497:Origin of Life; D058105:Polymerization; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012313:RNA / Q000235:genetics / Q000378:metabolism*; D014633:Valine / Q000378:metabolism
chemical_list: D011506:Proteins; D018698:Glutamic Acid; D012313:RNA; D014633:Valine; D000409:Alanine; D005998:Glycine