title: Progestogen treatments for cycle management in a sheep model of assisted conception affect the growth patterns, the expression of luteinizing hormone receptors, and the progesterone secretion of induced corpora lutea.
abstract: OBJECTIVE
  To determine, in a sheep model, the effect of a short-term progestative treatment on growth dynamics and functionality of induced corpora lutea.
  
  
  METHODS
  Observational, model study.
  
  
  METHODS
  Public university.
  
  
  METHODS
  Sixty adult female sheep.
  
  
  METHODS
  Synchronization and induction of ovulation with progestogens and prostaglandin analogues; ovarian ultrasonography, blood sampling, and ovariectomy.
  
  
  METHODS
  Determination of pituitary function and morphologic characteristics, expression of luteinizing hormone (LH) receptors, and progesterone secretion of corpora lutea.
  
  
  RESULTS
  The use of progestative pretreatments for assisted conception affect the growth patterns, the expression of LH receptors, and the progesterone secretion of induced corpora lutea.
  
  
  CONCLUSIONS
  The current study indicates, in a sheep model, the existence of deleterious effects from progestogens on functionality of induced corpora lutea.
authors.affiliation: Escuela de Graduados, Universidad Austral de Chile, Campus Isla Teja s/n, Casilla 567, Valdivia, Chile. claudialetelier@uach.cl
authors.forename: Claudia
authors.initials: C
authors.lastname: Letelier
authors.forename: Rosa Ana
authors.initials: RA
authors.lastname: García-Fernández
authors.forename: Ignacio
authors.initials: I
authors.lastname: Contreras-Solis
authors.forename: María Angeles
authors.initials: MA
authors.lastname: Sanchez
authors.forename: Pilar
authors.initials: P
authors.lastname: Garcia-Palencia
authors.forename: Belen
authors.initials: B
authors.lastname: Sanchez
authors.forename: Antonio
authors.initials: A
authors.lastname: Gonzalez-Bulnes
authors.forename: Juana María
authors.initials: JM
authors.lastname: Flores
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism*; D005260:Female; D003425:Flurogestone Acetate / Q000008:administration & dosage*; D008597:Menstrual Cycle / Q000187:drug effects / Q000502:physiology*; D023421:Models, Animal; D010060:Ovulation / Q000187:drug effects / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods; D011374:Progesterone / Q000378:metabolism*; D011372:Progestins / Q000008:administration & dosage*; D011974:Receptors, LH / Q000096:biosynthesis*; D012756:Sheep
chemical_list: D011372:Progestins; D011974:Receptors, LH; D011374:Progesterone; D003425:Flurogestone Acetate