Regulation of DGK-theta.
Diacylglycerol kinases are important regulators of lipid signaling and, consequently, important regulators of many diglyceride-dependent and PA-dependent proteins. Research over the last twenty years has clearly demonstrated that individual DGK isoforms can be connected with disparate cellular processes, indicating the presence of a sophisticated regulatory network for diglyceride and phosphatidic acid signaling through the regulation of individual DGK isoforms. This review presents the progress on the characterization of a primarily neuronal isoform DGK-theta, and examines current data on the primary structure, regulation and potential cellular functions of this enzyme.
Tu-Sekine
Becky
B
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. btusekine@jhmi.edu
Raben
Daniel M
DM
D000818:Animals; D019852:Diacylglycerol Kinase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004075:Diglycerides / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D007527:Isoenzymes; D008563:Membrane Lipids / Q000378:metabolism; D009474:Neurons / Q000201:enzymology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D015398:Signal Transduction; D009435:Synaptic Transmission
D004075:Diglycerides; D007527:Isoenzymes; D008563:Membrane Lipids; D018377:Neurotransmitter Agents; D010712:Phosphatidic Acids; D019852:Diacylglycerol Kinase