title: [Potent and continuous relief of spinal bone pain due to metastasis of non-small cell lung cancer by treatment with gefitinib--a case report].
abstract: A 79-year-old woman with advanced non-small cell lung cancer was admitted to our hospital for palliative terminal care after failure of initial radiotherapy followed by chemotherapy with S-1. She had severe back pain due to metastasis at the sixth thoracic spinal bone. Gefitinib was administered and rapid relief of bone pain was obtained. During the first four months, gradual reduction of all measurable lesions was obtained. However, these lesions except for spinal bone metastasis re-grew and five months later, she died of cachexia. Treatment with gefitinib was continued until she died because of the complete relief of bone pain.
authors.affiliation: Palliative Care Team, National Hospital Organization Nagasaki Hospital.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kanda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ito
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Mori
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D011799:Quinazolines / Q000627:therapeutic use*; D013131:Spine / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D011799:Quinazolines; D000077156:Gefitinib