Asymmetric tandem Michael addition-ylide olefination reaction for the synthesis of optically active cyclohexa-1,3-diene derivatives.
The reaction of a crotonate-derived chiral phosphonium salt with alpha,beta-unsaturated carbonyl compounds in the presence of Cs(2)CO(3) affords optically active cyclohexa-1,3-diene derivatives with up to 90% ee in good yields.
Ye
Long-Wu
LW
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Wang
Shou-Bing
SB
Wang
Qing-Gang
QG
Sun
Xiu-Li
XL
Tang
Yong
Y
Zhou
Yong-Gui
YG
D000475:Alkenes / Q000737:chemistry*; D053138:Cyclohexenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000475:Alkenes; D053138:Cyclohexenes