The calculus of integrating differentiation: timing control of T-bet.
In this issue of Immunity, Schulz et al. (2009) use mathematical modeling to elucidate a signaling network controlling Ifng gene expression, thereby showing the importance of an Interleukin-12-dependent, Interferon-gamma-independent second phase of inducing the transcription factor T-bet.
Boothby
Mark
M
Departments of Microbiology & Immunology and Medicine, Vanderbilt University School of Medicine, 1161 21(st) Avenue South, Nashville, TN 37232-2363, USA. mark.boothby@vanderbilt.edu
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D018664:Interleukin-12 / Q000276:immunology / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction; D020825:T-Box Domain Proteins / Q000378:metabolism*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D000098815:T-bet Transcription Factor
D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D018664:Interleukin-12; D007371:Interferon-gamma