title: A new triterpenoid from Brucea javanica.
abstract: A new triterpenoid, bruceajavanin C (1), together with bruceosides A and B (2 and 3), bruceines D and E (4 and 5), yadanziosides A and G (6 and 7), (20R)-O-(3)-alpha-L-arabinopyranosylpregn-5-ene-3beta,20-diol (8), and alpha-D-glucopyranoside, (3beta, 20R)-3-hydroxypregn-5-en-20-yl (9) were isolated from the aerial parts of Brucea javanica. The structure of 1 was elucidated on the basis of 2D-NMR spectroscopic analysis. In addition, compounds 1, 3, 4, 5, and 6 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
authors.forename: Jian Hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Jiang Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Hui Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Xiao Jia
authors.initials: XJ
authors.lastname: Hu
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.forename: Yun Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Shi Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D032269:Brucea / Q000737:chemistry*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D035261:Plant Components, Aerial; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D008070:Lipopolysaccharides; D014315:Triterpenes; C541579:bruceajavanin C; D009569:Nitric Oxide