Mouse models of altered protein kinase A signaling.
Protein kinase A (PKA) is an evolutionarily conserved protein which has been studied in model organisms from yeast to man. Although the cAMP-PKA signaling system was the first mammalian second messenger system to be characterized, many aspects of this pathway are still not well understood. Owing to findings over the past decade implicating PKA signaling in endocrine (and other) tumorigenesis, there has been renewed interest in understanding the role of this pathway in physiology, particularly as it pertains to the endocrine system. Because of the availability of genetic tools, mouse modeling has become the pre-eminent system for studying the physiological role of specific genes and gene families as a means to understanding their relationship to human diseases. In this review, we will summarize the current data regarding mouse models that have targeted the PKA signaling system. These data have led to a better understanding of both the complexity and the subtlety of PKA signaling, and point the way for future studies, which may help to modulate this pathway for therapeutic effect.
Kirschner
Lawrence S
LS
Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University, 420 West 12th Avenue, TMRF 544, Columbus, Ohio 43210, USA. lawrence.kirschner@osumc.edu
Yin
Zhirong
Z
Jones
Georgette N
GN
Mahoney
Emilia
E
D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D018390:Gene Targeting; D018014:Gene Transfer Techniques; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D021122:Protein Subunits / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D021122:Protein Subunits; D017868:Cyclic AMP-Dependent Protein Kinases