title: Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
abstract: Age at menarche and age at natural menopause are associated with causes of substantial morbidity and mortality such as breast cancer and cardiovascular disease. We conducted a joint analysis of two genome-wide association studies of these two traits in a total of 17,438 women from the Nurses' Health Study (NHS, N = 2,287) and the Women's Genome Health Study (WGHS, N = 15,151). For age at menarche, we identified ten associated SNPs (P = 1 × 10(-7)-3 × 10(-13)) clustered at 6q21 (in or near the gene LIN28B) and 9q31.2 (in an intergenic region). For age at natural menopause, we identified 13 associated SNPs (P = 1 × 10(-7)-1 × 10(-21)) clustered at 20p12.3 (in the gene MCM8), 19q13.42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L). These newly identified loci might expand understanding of the biological pathways regulating these two traits.
authors.affiliation: Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. che@hsph.harvard.edu
authors.forename: Chunyan
authors.initials: C
authors.lastname: He
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.forename: Constance
authors.initials: C
authors.lastname: Chen
authors.forename: Julie E
authors.initials: JE
authors.lastname: Buring
authors.forename: Guillaume
authors.initials: G
authors.lastname: Paré
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Paul M
authors.initials: PM
authors.lastname: Ridker
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Chasman
mesh_terms: D000367:Age Factors; D002874:Chromosome Mapping / Q000379:methods*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D008572:Menarche / Q000235:genetics*; D008593:Menopause / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide