Efficient syntheses of crispine A and harmicine by RH-catalyzed cyclohydrocarbonylation.
The first examples of Rh-catalyzed cyclohydrocarbonylation-bicyclization of N-allylic amides of arylacetic acids are reported. This novel carbonylative bicyclization process was successfully applied to the rapid syntheses of crispine A and its analogues (tricyclic indolizidine alkaloids) as well as harmicine (tetracyclic beta-carboline alkaloid).
Chiou
Wen-Hua
WH
Department of Chemistry, National Chung Hsing University, Taichung, Taiwan, ROC. wchiou@dragon.nchu.edu.tw
Lin
Gau-Hong
GH
Hsu
Che-Cheng
CC
Chaterpaul
Stephen J
SJ
Ojima
Iwao
I