title: Impact of different metabolic syndrome classifications on the metabolic syndrome prevalence in a young Middle Eastern population.
abstract: The metabolic syndrome (MetS) prevalence in a young Middle Eastern population has never been studied. We studied this prevalence in a randomly selected population of Lebanese students using different MetS classifications. Three hundred eighty-one subjects aged 18 to 30 years were included in the study. Anthropometric and biological parameters (waist circumference [WC], systolic and diastolic blood pressures, fasting plasma glucose, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and homeostasis model assessment [HOMA] index to assess insulin resistance) were measured. Receiver operating characteristic (ROC) curves were generated to determine population-specific cutoff values for MetS parameters and HOMA index. The MetS prevalence was calculated using the National Cholesterol Education Program's Adult Treatment Panel III (ATP-III), the actualized ATP-III, and our cutoffs, either with or without HOMA index as an extra risk factor. The MetS prevalence using the ATP-III and the actualized ATP-III was, respectively, 5.25% and 5.28%. It increased to 9.19% when using our cutoff values and to 12.64% when HOMA index was added. This increase was significant only in men. The identified cutoff values are, for WC, 91 cm in women and 99.5 cm in men and, for HOMA index, 2.32. Among the MetS components, WC was the best MetS predictor, whereas fasting plasma glucose was the poorest. Our study shows that the MetS prevalence in Lebanon is comparable with other countries. In addition, we identified in our population new cutoff points for MetS parameters and HOMA index that allow the detection of a higher number of subjects with the MetS, mainly in the male population.
authors.affiliation: Department of Biochemistry, Saint-Joseph University, P.B. 11-5076 Riad El Solh, Beirut 1107 2180, Lebanon. rima.chedid@usj.edu.lb
authors.forename: Rima
authors.initials: R
authors.lastname: Chedid
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Gannagé-Yared
authors.forename: Simon
authors.initials: S
authors.lastname: Khalifé
authors.forename: Georges
authors.initials: G
authors.lastname: Halaby
authors.forename: Fernand
authors.initials: F
authors.lastname: Zoghbi
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D001794:Blood Pressure; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D007861:Lebanon / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology*; D017410:Practice Guidelines as Topic; D015995:Prevalence; D012372:ROC Curve; D012737:Sex Factors; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008055:Lipids