Fat circadian biology.
While adipose tissue has long been recognized for its major role in metabolism, it is now appreciated as an endocrine organ. A growing body of literature has emerged that identifies circadian mechanisms as a critical regulator of adipose tissue differentiation, metabolism, and adipokine secretory function in both health and disease. This concise review focuses on recent data from murine and human models that highlights the interplay between the core circadian regulatory proteins and adipose tissue in the context of energy, fat, and glucose metabolism. It will be important to integrate circadian mechanisms and networks into future descriptions of adipose tissue physiology.
Gimble
Jeffrey M
JM
Pennington Biomedical Research Center, Louisiana State Univ., Stem Cell Biology Laboratory, 6400 Perkins Rd., Baton Rouge, LA 70808, USA. gimblejm@pbrc.edu
Floyd
Z Elizabeth
ZE
D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D001695:Biology / Q000379:methods; D002940:Circadian Rhythm / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological