title: Human exposure to selected animal neurocarcinogens: a biomarker-based assessment and implications for brain tumor epidemiology.
abstract: This review is based on the proceedings from the Second Lebow Conference, held in Chicago in 2007. The conference concentrated on developing a framework for innovative studies in the epidemiology of environmental exposures, focusing specifically on the potential relationship with brain tumors. Researchers with different perspectives, including toxicology, pharmacokinetics, and epidemiological exposure assessment, exchanged information and ideas on the use of biomarkers of exposure in molecular epidemiology studies and summarized the current knowledge on methods and approaches for biomarker-based exposure assessment. This report presents the state of science regarding biomarker-based exposure assessment of the four most common neurocarcinogens: acrylamide, 1,3-butadiene, N-nitroso compounds, and polycyclic aromatic hydrocarbons. Importantly, these chemicals are also carcinogenic in other organs; therefore, this discussion is useful for environmental epidemiologists studying all cancer types.
authors.affiliation: Preston Robert Tisch Brain Tumor Center at Duke and Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. dora.ilyasova@duke.edu
authors.forename: Dora
authors.initials: D
authors.lastname: Il'yasova
authors.forename: Bridget J
authors.initials: BJ
authors.lastname: McCarthy
authors.forename: Serap
authors.initials: S
authors.lastname: Erdal
authors.forename: Joanna
authors.initials: J
authors.lastname: Shimek
authors.forename: Jennifer
authors.initials: J
authors.lastname: Goldstein
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Doerge
authors.forename: Steven R
authors.initials: SR
authors.lastname: Myers
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: John S
authors.initials: JS
authors.lastname: Wishnok
authors.forename: James A
authors.initials: JA
authors.lastname: Swenberg
authors.forename: Darell D
authors.initials: DD
authors.lastname: Bigner
authors.forename: Faith G
authors.initials: FG
authors.lastname: Davis
mesh_terms: D020106:Acrylamide / Q000009:adverse effects; D000818:Animals; D000830:Animals, Laboratory; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D002070:Butadienes / Q000009:adverse effects; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D004784:Environmental Monitoring / Q000379:methods; D062665:Epidemiological Monitoring; D006801:Humans; D017720:Molecular Epidemiology; D009603:Nitroso Compounds / Q000009:adverse effects; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects; D018570:Risk Assessment
chemical_list: D014408:Biomarkers, Tumor; D002070:Butadienes; D002274:Carcinogens, Environmental; D009603:Nitroso Compounds; D011084:Polycyclic Aromatic Hydrocarbons; D020106:Acrylamide; C031763:1,3-butadiene