A preliminary association study between brain-derived neurotrophic factor (BDNF) haplotype and late-onset depression in mainland Chinese.
OBJECTIVE
The present study aimed to assess the association of genotypes and haplotypes in brain-derived neurotrophic factor (BDNF) polymorphisms with late-onset depression (LOD) in a Chinese Han population.


METHODS
144 subjects with LOD and 110 control subjects were recruited for the study, assessed using the Hamilton Rating Scale for Depression, and genotyped for 712G/A, 270C/T, 196A/G and 11757G/C variants by polymerase chain reaction.


RESULTS
No differences were found in the frequencies of the alleles and genotypes of tested BDNF gene between LOD patients and normal group. Interestingly, the distributions of 712G-270T, 196A-11757G, 196G-11757C, 712G-196A-11757G, 712G-196G-11757C, 270C-196A-11757G, 270C-196G-11757C, 712G-270C-196A-11757G, 712G-270C-196G-11757C haplotypes were significantly higher in LOD compared to healthy controls (all P<0.05).


CONCLUSIONS
The results tentatively suggest that BDNF haplotypes might be the susceptibility for LOD.
You
Jiayong
J
Department of Psychiatry, Nanjing Medical University, Nanjing, 210029, China.
Yuan
Yonggui
Y
Zhang
Zhijun
Z
Zhang
Xiangrong
X
Li
Hailin
H
Qian
Yun
Y
D017668:Age of Onset; D000368:Aged; D044466:Asian People / Q000523:psychology* / Q000706:statistics & numerical data*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002681:China / Q000453:epidemiology; D017931:DNA Primers / Q000235:genetics; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D016133:Polymerase Chain Reaction; D011795:Surveys and Questionnaires
D019208:Brain-Derived Neurotrophic Factor; D017931:DNA Primers