Biological variation in fasting serum insulin-like growth factor binding protein-1 (IGFBP-1) among individuals with a varying glucose tolerance.
OBJECTIVE
To evaluate the biological variation of serum insulin-like growth factor binding protein-1 (IGFBP-1) in individuals with different degrees of glucose tolerance.


METHODS
IGFBP-1 was measured in 42 fasted subjects with: normal glucose tolerance (NGT=15), impaired fasting glucose (IFG=9), impaired glucose tolerance (IGT=9) and type 2 diabetics (DM=9). Short- and long-term reproducibility was determined for IGFBP-1.


RESULTS
The longer-term reproducibility (CV) of serum IGFBP-1 was 20.9%, 29.5%, 33.1% and 48.0% for subjects with NGT, IFG, IGT and DM respectively. The results for the short-term serum IGFBP-1 yielded CVs for these same respective categories of 8.2%, 16.1%, 29.2% and 13.8%.


CONCLUSIONS
IGFBP-1 measurement was least variable in NGT individuals over both long-term and short-term intervals and variability increased with deteriorating glucose tolerance. Due to its biological variation, IGFBP-1 serum level is more reliable in normal subjects than in individuals with type 2 diabetes.
Borai
Anwar
A
University of Surrey, Guildford, UK. a.al-borai@surrey.ac.uk
Livingstone
Callum
C
Mehta
Shweta
S
Zarif
Hawazen
H
Abdelaal
Fatima
F
Ferns
Gordon
G
D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D005215:Fasting / Q000097:blood*; D018149:Glucose Intolerance / Q000097:blood*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D015203:Reproducibility of Results
D018970:Insulin-Like Growth Factor Binding Protein 1