Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A.
It is well established that cAMP signaling within neurons plays a major role in the formation of long-term memories--signaling thought to proceed through protein kinase A (PKA). However, here we show that exchange protein activated by cAMP (Epac) is able to enhance the formation of long-term memory in the hippocampus and appears to do so independent of PKA, thus demonstrating the importance of Epac-mediated signaling in memory consolidation.
Ma
Nan
N
University of Pennsylvania, Department of Biology, Philadelphia, Pennsylvania 19104, USA.
Abel
Ted
T
Hernandez
Pepe J
PJ
D000818:Animals; D001522:Behavior, Animal; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation / Q000379:methods; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005239:Fear; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D018091:Receptors, AMPA / Q000378:metabolism; D012694:Serine / Q000378:metabolism; D013873:Thionucleotides / Q000494:pharmacology; D013997:Time Factors; D020827:rap1 GTP-Binding Proteins / Q000378:metabolism
D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D004791:Enzyme Inhibitors; D018091:Receptors, AMPA; D012694:Serine; D013873:Thionucleotides; D020827:rap1 GTP-Binding Proteins; C473217:8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate; C016957:adenosine-3',5'-cyclic phosphorothioate