title: A novel antibiotic, linezolid, reduces intraperitoneal adhesion formation in the rat uterine horn model.
abstract: OBJECTIVE
  To examine the effects of linezolid in prevention of adhesion formation in a rat uterine horn model.
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  University Experimental Animal Research Laboratory Center.
  
  
  METHODS
  Ninety female Wistar albino rats.
  
  
  METHODS
  A dose response study was first conducted with 60 Wistar albino rats that were randomly assigned to six equal groups by administering vehicle (control), 5 mg/kg (Group 1), 15 mg/kg (Group 2), 50 mg/kg (Group 3), 100 mg/kg (Group 4), and 150 mg/kg (Group 5) linezolid starting three days before the adhesion inducing operation and continuing for 14 days postoperatively. Adhesion was scored clinically with a scoring system. The minimum effective dose was found to be 100 mg/kg/day. With this dose time response (starting three days before the operation and continuing for seven days), only preoperative and postoperative administration studies were conducted.
  
  
  METHODS
  Extent and severity of adhesions.
  
  
  RESULTS
  Total adhesion scores in the control and Groups 1 and 2 were significantly higher when compared with Groups 4 and 5, but not with Group 3. There were no significant differences in the adhesion scores between Groups 3, 4, and 5. In time response arm a total of 10 days treatment was not as effective as 17 days treatment. In postoperative and preoperative arms of the study, it was found that administration of linezolid only postoperatively or preoperatively did not affect adhesion formation significantly when compared with the control group.
  
  
  CONCLUSIONS
  Linezolid was found to reduce intraperitoneal adhesion formation.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey. drhakanaytan@yahoo.com
authors.forename: Hakan
authors.initials: H
authors.lastname: Aytan
authors.forename: Ahmet C
authors.initials: AC
authors.lastname: Caliskan
authors.forename: Tamer
authors.initials: T
authors.lastname: Yener
authors.forename: Fazli
authors.initials: F
authors.lastname: Demirturk
authors.forename: Pelin
authors.initials: P
authors.lastname: Aytan
authors.forename: Aydan
authors.initials: A
authors.lastname: Yenisehirli
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D000069349:Linezolid; D023303:Oxazolidinones / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D000267:Tissue Adhesions / Q000473:pathology*; D014599:Uterus / Q000187:drug effects / Q000473:pathology
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid