title: ACE insertion/deletion polymorphism and its relationships to the components of metabolic syndrome in elderly Slovaks.
abstract: The purpose of this study was to assess clustering of Metabolic Syndrome components in aged Slovaks, and to investigate whether insertion/deletion (I/D) polymorphism of the human angiotensin-converting enzyme (ACE) gene is associated with this syndrome. Data were available from 374 Slovak participants (200 females and 174 males) ranging in age between 60 and 90 years. ACE I/D polymorphism was determined by PCR amplification of the ACE gene sequence. Metabolic Syndrome was diagnosed according to criteria in the NCEP ATP-III. Elderly males and females differ significantly in the prevalence of Metabolic Syndrome (females 45.1%, males 24.8%). The males and females including subjects with and without metabolic syndrome, respectively, did not differ significantly in the three genotype distributions (p = 0.603 and p = 0.247). The allele frequencies (D = 0.5483, I = 0.4517) in the entire sample fell within the Hardy-Weinberg equilibrium. There was no confirmed association between ACE genotype and phenotypic variation in the recognized risk components for Metabolic Syndrome in elderly Slovaks. Among other factors which may induce a difference in Metabolic Syndrome, significant effect was detected for sex, BMI, HDL, TG, glucose and the ApoB/ApoA1 ratio.
authors.affiliation: Department of Anthropology, Faculty of Sciences, Comenius University, Bratislava, Slovak Republic sivakova@fns.uniba.sk
authors.forename: Daniela
authors.initials: D
authors.lastname: Siváková
authors.forename: Alica
authors.initials: A
authors.lastname: Lajdová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Basistová
authors.forename: Marta
authors.initials: M
authors.lastname: Cvícelová
authors.forename: Pavel
authors.initials: P
authors.lastname: Blazícek
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016000:Cluster Analysis; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D012737:Sex Factors; D018154:Slovakia
chemical_list: D007703:Peptidyl-Dipeptidase A