title: Severe hemophagocytic syndrome developing after treatment initiation for disseminated Mycobacterium tuberculosis: case report and literature review.
abstract: We describe a case of a young male with disseminated tuberculosis and severe secondary hemophagocytic syndrome. He presented with symptoms of tuberculosis and Mycobacterium tuberculosis was diagnosed. Later, while on anti-tuberculous treatment, he developed pancytopenia and bone marrow aspirate showed large macrophages with increased phagocytosis of mature and immature blood elements typical of hemophagocytic syndrome.
authors.affiliation: Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Maher M
authors.initials: MM
authors.lastname: Balkis
authors.forename: Lama
authors.initials: L
authors.lastname: Bazzi
authors.forename: Ali
authors.initials: A
authors.lastname: Taher
authors.forename: Ziad
authors.initials: Z
authors.lastname: Salem
authors.forename: Imad
authors.initials: I
authors.lastname: Uthman
authors.forename: Nadim
authors.initials: N
authors.lastname: Kanj
authors.forename: Fouad I
authors.initials: FI
authors.lastname: Boulos
authors.forename: Souha S
authors.initials: SS
authors.lastname: Kanj
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology; D008297:Male; D009169:Mycobacterium tuberculosis; D016896:Treatment Outcome; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents