title: Gastrointestinal lesions associated with spondyloarthropathies.
abstract: Subclinical gut inflammation has been described in up to two-thirds of patients with spondyloarthropathies (SpA). Arthritis represents an extra-intestinal manifestation of several gastrointestinal diseases, including inflammatory bowel disease (IBD), Whipple's disease, Behcet's disease, celiac disease, intestinal bypass surgery, parasitic infections of the gut and pseudomembranous colitis. Moreover about two-thirds of nonsteroidal anti-inflammatory drug users demonstrate intestinal inflammation. Arthritis may manifest as a peripheral or axial arthritis. The spondyloarthropathy family consists of the following entities: ankylosing spondylitis, undifferentiated spondyloarthritis, reactive arthritis, psoriatic arthritis, spondyloarthritis associated with IBD, juvenile onset spondyloarthritis. This topic reviews the major gastrointestinal manifestations that can occur in patients with SpA and in nonsteroidal anti-inflammatory drugs users.
authors.affiliation: Department of General Medicine, Pneumology and Nutrition Clinic, V Cervello Hospital, Palermo University, Palermo, Italy. ambrogiorlando@alice.it
authors.forename: Ambrogio
authors.initials: A
authors.lastname: Orlando
authors.forename: Sara
authors.initials: S
authors.lastname: Renna
authors.forename: Giovanni
authors.initials: G
authors.lastname: Perricone
authors.forename: Mario
authors.initials: M
authors.lastname: Cottone
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D025242:Spondylarthropathies / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal