title: Determination of human absorbed dose of 67GA-DTPA-ACTH based on distribution data in rats.
abstract: The absorbed radiation dose to human organs has been estimated, following intravenous administration of (67)Ga-labelled adrenocorticotrophic hormone (ACTH) using distribution data from injected normal rats. Four rats were sacrificed at exact time intervals and the percentage of injected dose per gram of each organ was measured by direct counting from rat data. The Medical Internal Radiation Dose formulation was applied to extrapolate from rat to human and to project the absorbed radiation dose for various organs in a human. From rat data, it is estimated that a 185-MBq injection of (67)Ga-diethylenetriaminepentaacetic acid-ACTH into a human might result in an estimated absorbed dose of 2.22 mGy to the whole body; the highest absorbed dose was in the bladder wall with 82.1 mGy and the organs that received the next highest doses were the lungs 31.8, liver 22.6 and spleen 8.72 mGy. These results suggest that it should be possible to perform early imaging of the lung anomalies.
authors.affiliation: Department of Biomedical Physics and Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. shanehsazzadeh@razi.tums.ac.ir
authors.forename: Saeed
authors.initials: S
authors.lastname: Shanehsazzadeh
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Jalilian
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Sadeghi
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Allahverdi
mesh_terms: D000042:Absorption; D000324:Adrenocorticotropic Hormone / Q000493:pharmacokinetics*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002614:Chelating Agents / Q000493:pharmacokinetics*; D005260:Female; D005710:Gallium Radioisotopes; D006728:Hormones / Q000493:pharmacokinetics*; D006801:Humans; D009929:Organ Size / Q000187:drug effects; D004369:Pentetic Acid / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D051381:Rats; D014018:Tissue Distribution
chemical_list: D002614:Chelating Agents; D005710:Gallium Radioisotopes; D006728:Hormones; D004369:Pentetic Acid; D000324:Adrenocorticotropic Hormone