title: Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT.
abstract: We aimed at securing sufficient concentrations of (10)B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron component liposome. It consisted of three different kinds of amino acid derivatives and two fatty acids, and could react directly with the peptide synthesized first on resin by Fmoc solid-phase synthesis. In this study, lipid analog conjugated with HIV-TAT peptide (domain of human immunodeficiency virus TAT protein) and boronophenylalanine (BPA) was synthesized and successfully incorporated into liposomes.
authors.affiliation: Department of Graduate School of Comprehensive Human Sciences, Faculty of Functional and Regulatory Medical Sciences, University of Tsukuba, Japan. m0720347@md.tsukuba.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Shirakawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamto
authors.forename: Kei
authors.initials: K
authors.lastname: Nakai
authors.forename: Kenichi
authors.initials: K
authors.lastname: Aburai
authors.forename: Sho
authors.initials: S
authors.lastname: Kawatobi
authors.forename: Takao
authors.initials: T
authors.lastname: Tsurubuchi
authors.forename: Yohei
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Yuusaku
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Okuno
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumura
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D016503:Drug Delivery Systems; D006801:Humans; D007554:Isotopes / Q000737:chemistry / Q000627:therapeutic use; D055666:Lipopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D008081:Liposomes / Q000737:chemistry*; D008564:Membrane Potentials; D009369:Neoplasms / Q000532:radiotherapy; D010316:Particle Size; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D001896:Boron Compounds; D007554:Isotopes; D055666:Lipopeptides; D008081:Liposomes; D011838:Radiation-Sensitizing Agents; D054322:tat Gene Products, Human Immunodeficiency Virus; D010649:Phenylalanine; C033685:4-boronophenylalanine