Is factor V Leiden mutation a cause of in vitro fertilization failure?
This prospective cohort study tested whether the most common hereditary thrombophilia, factor V Leiden (FVL) mutation, is associated with nonpregnancy after IVF. Factor V Leiden mutation prevalence was very low (1.6%) and had a preliminarily positive association with pregnancy, suggesting that routine testing in a general IVF population for FVL mutation as a cause of IVF failure and infertility is not indicated.
Rudick
Briana
B
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California.
Su
H Irene
HI
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Sammel
Mary D
MD
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Kovalevsky
George
G
Reproductive Associates of Delaware, Wilmington, Delaware.
Shaunik
Alka
A
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Barnhart
Kurt
K
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Electronic address: kbarnhart@obgyn.upenn.edu.
D000328:Adult; D015331:Cohort Studies; D005165:Factor V / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D005787:Gene Frequency; D005820:Genetic Testing; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D020125:Mutation, Missense / Q000502:physiology; D011247:Pregnancy; D011379:Prognosis; D017211:Treatment Failure; D055815:Young Adult
C095381:factor V Leiden; D005165:Factor V