Adrenocorticotropic hormone, melanocyte-stimulating hormone, and the melanocortin receptors: revisiting the work of Robert Schwyzer: a thirty-year retrospective.
In 1977 Dr. Robert Schwyzer wrote the review ACTH: A Short Introductory Review, which provided a reference point for current structure/function studies on the interactions between adrenocorticotropic hormone and alpha-melanocyte-stimulating hormone and the melanocortin receptors. This mini review will evaluate how the predictions made in the 1977 review have held up and also propose a mechanism to explain the ligand selectivity properties of the melanocortin receptors.
Dores
Robert M
RM
Department of Biological Sciences, University of Denver, Denver, Colorado 80210, USA. rdores@du.edu
D000324:Adrenocorticotropic Hormone / Q000737:chemistry / Q000266:history* / Q000378:metabolism*; D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008024:Ligands; D009074:Melanocyte-Stimulating Hormones / Q000266:history* / Q000378:metabolism*; D011485:Protein Binding; D044101:Receptors, Melanocortin / Q000266:history* / Q000378:metabolism*
D008024:Ligands; D044101:Receptors, Melanocortin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones