Hyperlipidemia and hyperinsulinemia in the spontaneous osteoarthritis mouse model, STR/Ort.
Recent studies have focused on the association between primary osteoarthritis and dyslipidemia. STR/Ort mice have unique characteristics including osteoarthritis and hyperlipidemia, and may be a useful model for investigating the effect of dyslipidemia on the underlying mechanism of primary osteoarthritis. However, little is known about the hyperlipidemic properties of STR/Ort mice. In this study we investigated hyperlipidemia and lipotoxicity in STR/Ort mice. STR/Ort mice have human hyperlipidemic patient-like symptoms such as hypercholesteremia, hypertriglyceridemia, hyperinsulinemia, insulin resistance, dysregulation of NEFA, and low serum adiponectin. Excess triglyceride accumulation in the liver of STR/Ort mice was not observed even when they exhibited hyperinsulinemia. This information may be useful for researchers investigating lipid metabolism and primary osteoarthritis using STR/Ort mice.
Uchida
Kentaroo
K
Department of Biomedical Engineering, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan.
Urabe
Ken
K
Naruse
Kouji
K
Ogawa
Zensuke
Z
Mabuchi
Kiyoshi
K
Itoman
Moritoshi
M
D052242:Adiponectin / Q000097:blood; D000367:Age Factors; D000818:Animals; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications / Q000235:genetics*; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010003:Osteoarthritis / Q000097:blood / Q000150:complications / Q000235:genetics*; D014280:Triglycerides / Q000378:metabolism
D052242:Adiponectin; C499919:Adipoq protein, mouse; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides