Sonographic diagnosis for Mikulicz disease.
OBJECTIVE
The aim was to investigate the diagnostic imaging characteristics of Mikulicz disease (MD), especially sonographic ones, and to clarify the differences between them and those in Sjögren syndrome (SS), based on new criteria of MD.


METHODS
The sonographic and sialographic images, as well as clinical, histopathologic, and serologic findings of 9 patients satisfying the new criteria of MD were analyzed and compared with those in SS.


RESULTS
All swollen submandibular glands showed bilateral nodal hypoechoic areas with high vascularization on sonograms and a parenchymal defect on sialograms, whereas parotid glands showed normal or slight change on both images. Nodal areas in submandibular gland sonograms were unclear on computerized tomography and on magnetic resonance imaging, but showed accumulation on gallium scintigraphy.


CONCLUSIONS
Mikulicz disease showed a high rate of bilateral nodal change in submandibular glands, which was completely different from SS. For detection and follow-up of these changes, sonography may be the best imaging modality.
Shimizu
Mayumi
M
Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka, Japan. shimizu@rad.dent.kyushu-u.ac.jp
Moriyama
Masafumi
M
Okamura
Kazutoshi
K
Kawazu
Toshiyuki
T
Chikui
Toru
T
Goto
Tazuko K
TK
Ohyama
Yukiko
Y
Nakamura
Seiji
S
Yoshiura
Kazunori
K
D000328:Adult; D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008214:Lymphocytes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008882:Mikulicz' Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D010305:Parotid Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012463:Saliva / Q000378:metabolism; D012796:Sialography; D012859:Sjogren's Syndrome / Q000175:diagnosis; D013364:Submandibular Gland Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D005710:Gallium Radioisotopes; D007074:Immunoglobulin G; D019275:Radiopharmaceuticals