title: The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy.
abstract: OBJECTIVE
  Interleukin-1beta (IL-1beta) polymorphisms are associated with peptic ulcer and atrophic gastritis. This study aimed to examine effects of corpus atrophy and the genotypes of genes related to peptic ulcer, including IL-1beta, on risk of aspirin ulcer.
  
  
  METHODS
  232 patients taking 100 mg of aspirin for cardiovascular diseases, of whom 40 had peptic ulcer, were enrolled. IL1beta, interleukin-1 receptor antagonist (IL-1RN), tumor necrosis factor (TNF)-alpha, cyclooxygenase (COX)-1, cytochrome p450 2C9 (CYP2C9), UDP-glucuronosyltransferase (UGT1A6) genotypes were determined, and serum pepsinogen levels were measured.
  
  
  RESULTS
  The polymorphisms of IL-1beta-511/-31 were significantly associated with peptic ulcer, but other genotypes were not. Serum pepsinogen I and II levels and I/II ratio were significantly higher in the ulcer group than in the non-ulcer group. Taking PPI [adjusted odds ratio (OR), 0.09; 95% confidence interval (CI), 0.02-0.39], pepsinogen I of less than 50 ng/ml (OR, 0.24; 95% CI, 0.10-0.56) and IL-1beta-511 T carrier (OR, 0.42; 95% CI, 0.18-0.93) were significantly associated with peptic ulcer.
  
  
  CONCLUSIONS
  Hypoacidity related to corpus atrophy as well as taking PPI seems to be preventively associated with development of peptic ulcer among low dose aspirin users.
authors.affiliation: Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. shiotani@med.kawasaki-m.ac.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Shiotani
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakakibara
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Yamanaka
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nishi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imamura
authors.forename: Minoru
authors.initials: M
authors.lastname: Fujita
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Tarumi
authors.forename: Tomoari
authors.initials: T
authors.lastname: Kamada
authors.forename: Jiro
authors.initials: J
authors.lastname: Hata
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
mesh_terms: D000368:Aged; D001241:Aspirin / Q000009:adverse effects*; D001284:Atrophy / Q000150:complications; D051545:Cyclooxygenase 1 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D010435:Pepsinogens / Q000097:blood*; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic
chemical_list: D053583:Interleukin-1beta; D010435:Pepsinogens; D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human; D001241:Aspirin