title: Nasal sumatriptan as adjunctive therapy for idiopathic trigeminal neuralgia: report of three cases.
abstract: We examine the effect of nasal sumatriptan as an adjunctive therapy in 3 patients with idiopathic trigeminal neuralgia refractory to carbamazepine (CBZ) and found that this therapy might be suitable for patients for whom the CBZ dose cannot be increased, who are under poor pain control, and who are not candidates for nerve blocks or surgery.
authors.affiliation: Takasaki Pain Clinic, Takasaki, Gunma, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Shimohata
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Shimohata
authors.forename: Ryoichiro
authors.initials: R
authors.lastname: Motegi
authors.forename: Kou
authors.initials: K
authors.lastname: Miyashita
mesh_terms: D000281:Administration, Intranasal; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage; D002220:Carbamazepine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance / Q000502:physiology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D020078:Neurogenic Inflammation / Q000188:drug therapy / Q000503:physiopathology; D009479:Neuropeptides / Q000037:antagonists & inhibitors / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage*; D018170:Sumatriptan / Q000008:administration & dosage*; D016896:Treatment Outcome; D014276:Trigeminal Nerve / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D014277:Trigeminal Neuralgia / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D009479:Neuropeptides; D017366:Serotonin Receptor Agonists; D002220:Carbamazepine; D018170:Sumatriptan