title: Anion complexation of a pentafluorophenyl-substituted tripodal urea receptor in solution and the solid state: selectivity toward phosphate.
abstract: The binding and selectivity of halides (spherical) and oxyanions (tetrahedral) toward a recently reported pentafluorophenyl-substituted tripodal urea-based receptor L(1) are examined thoroughly in the solid state by single-crystal X-ray crystallography as well as in solution by multinuclear NMR techniques. Crystallographic results show proof of a fluoride encapsulation in the cavity of L(1) in complex [L(1)(F)][Bu(4)N], . Fluoride encapsulation inside the C(3v) symmetric cleft is observed via six hydrogen bonds to all six urea protons of the receptor. In case of complex crystallographic results show encapsulation of sulfate ion inside a supramolecular cage formed upon 1 : 2 (guest-host) complex formation between sulfate and L(1). Sulfate encapsulation is observed via fourteen hydrogen bonding interactions from all six urea moieties of two L(1) units. Our effort to isolate single crystal of halides/oxyanions complexes of L(2) always yield single crystals of free L(2) though literature shows anion binding with this receptor in solution. Solution state binding studies of L(1) are carried out by (1)H-NMR titration to calculate binding constants, which show the following anion binding sequence H(2)PO(4)(-) > SO(4)(2-)> CH(3)COO(-) > F(-) > Cl(-) >> Br(-) whereas there is no binding with I(-), NO(3)(-) and ClO(4)(-) guests. Comparison of phosphate and sulfate binding in L(1) and L(2), show higher binding with the pentafluorophenyl substituted receptor, L(1). Further (19)F and (31)P-NMR experiments in solution are also carried out to probe the binding of F(-) and H(2)PO(4)(-) with L(1), respectively. Extensive (1)H-NMR experiments in solution and crystallization in the presence of multiple anions are also undertaken to evaluate the selectivity of H(2)PO(4)(-) over other anions.
authors.affiliation: Department of Inorganic Chemistry, Indian Association for the Cultivation of Science, 2A and 2B Raja S. C. Mullick Road, Kolkata 700032, India.
authors.forename: I
authors.initials: I
authors.lastname: Ravikumar
authors.forename: P S
authors.initials: PS
authors.lastname: Lakshminarayanan
authors.forename: M
authors.initials: M
authors.lastname: Arunachalam
authors.forename: E
authors.initials: E
authors.lastname: Suresh
authors.forename: Pradyut
authors.initials: P
authors.lastname: Ghosh