title: A study on the association of the chromosome 12p13 locus with sporadic late-onset Alzheimer's disease in Chinese.
abstract: Recent linkage and association studies have implicated the chromosome 12p13 locus as possibly harboring genetic variants predisposed to Alzheimer's disease (AD). We attempted to replicate this association in a Chinese data set comprised of 256 AD cases and 264 age-matched normal controls. A total of 14 single nucleotide polymorphisms (SNPs) were examined. Single marker association revealed the two SNPs in NCAPD2 (rs7311174 and rs2072374) as showing nominal significant p values (p = 0.0491 and 0.0116, respectively). Haplotype analysis found LD block one to be significantly associated with AD (global p = 0.0250). Haplotypes CGGATG and CAGTCG were also significantly associated with AD (p = 0.0498 and p = 0.0482, respectively). These genetic analyses provide evidence that the chromosome 12p13 locus is associated with AD in Chinese.
authors.affiliation: Department of Biochemistry, University of Hong Kong, Hong Kong, SAR, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Leung Wing
authors.initials: LW
authors.lastname: Chu
authors.forename: Zhong
authors.initials: Z
authors.lastname: Li
authors.forename: Ping-Yiu
authors.initials: PY
authors.lastname: Yik
authors.forename: You-Qiang
authors.initials: YQ
authors.lastname: Song
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D000072556:Cholesterol 24-Hydroxylase; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013250:Steroid Hydroxylases / Q000235:genetics
chemical_list: D013250:Steroid Hydroxylases; D000072556:Cholesterol 24-Hydroxylase