title: Central giant cell lesion of the jaw: nonsurgical treatment with calcitonin nasal spray.
abstract: OBJECTIVE
  The aim was to evaluate the effectiveness of the long-term administration of intranasal calcitonin spray for the treatment of central giant cell granuloma (CGCG) in a retrospective case study.
  
  
  METHODS
  The medical files of 5 patients (4 male, 1 female; ages 8-66 years) with CGCG of the jaws treated with calcitonin nasal spray 200 U/spray once or twice daily were reviewed for lesion-related parameters, outcome, and adverse effects of therapy.
  
  
  RESULTS
  Three lesions were located in the mandibular body and ramus region and 2 in the anterior maxilla. Mean lesion size on radiography was 3.2 x 2.3 cm. The duration of calcitonin treatment was 9-60 months (mean 28 months). All the lesions considerably decreased in size with a high degree of calcification. There were no recurrences.
  
  
  CONCLUSIONS
  Calcitonin nasal spray appears to be safe and effective for the treatment of CGCG and might be considered an alternative to surgery. Further controlled studies are needed to corroborate these findings.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel. drorallon@gmail.com
authors.forename: Dror M
authors.initials: DM
authors.lastname: Allon
authors.forename: Yakir
authors.initials: Y
authors.lastname: Anavi
authors.forename: Shlomo
authors.initials: S
authors.lastname: Calderon
mesh_terms: D000281:Administration, Intranasal; D000336:Aerosols / Q000008:administration & dosage; D000368:Aged; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D002116:Calcitonin / Q000008:administration & dosage*; D002648:Child; D005260:Female; D006101:Granuloma, Giant Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008336:Mandibular Diseases / Q000188:drug therapy* / Q000473:pathology; D008439:Maxillary Diseases / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000336:Aerosols; D050071:Bone Density Conservation Agents; D002116:Calcitonin