In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates.
Glutathione reductase (GR), is responsible for the existence of GSH molecule, a crucial antioxidant against oxidative stress reagents. The antimalarial activities of some redox active compounds are attributed to their inhibition of antioxidant flavoenzyme glutathione reductase, and inhibitors are therefore expected to be useful for the treatment of malaria. Twelve organic nitrate derivatives were synthesized and treated with human erythrocyte GR. The molecules were identified as strong GR inhibitors and novel antimalaria candidates.
Sentürk
Murat
M
Atatürk University, Faculty of Science, Department of Chemistry, Erzurum, Turkey. senturkm36@gmail.com
Talaz
Oktay
O
Ekinci
Deniz
D
Cavdar
Hüseyin
H
Küfrevioğlu
Omer Irfan
OI
D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004912:Erythrocytes / Q000201:enzymology*; D005980:Glutathione Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D009566:Nitrates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D000962:Antimalarials; D004791:Enzyme Inhibitors; D009566:Nitrates; D005980:Glutathione Reductase