Pharmacokinetics of intravenous piperacillin administration in patients undergoing on-line hemodiafiltration.
The pharmacokinetic characteristics of piperacillin sodium were studied in five volunteers undergoing on-line hemodiafiltration (HDF). The subjects were given 2 g of piperacillin sodium intravenously over 1 min and placed on on-line HDF for 4 h starting at 60 min after the piperacillin infusion. Noncompartmental models were employed for estimation of the pharmacokinetic parameters, and intradialytic piperacillin clearance was calculated by the recovery method. The mean volume of distribution and the elimination half-life were 0.27 +/- 0.13 liter/kg (mean +/- standard deviation) and 1.1 +/- 0.6 h, respectively. The total body clearance of piperacillin was 0.19 +/- 0.08 liter/h/kg. Piperacillin clearance through on-line HDF was 0.11 +/- 0.06 liter/h/kg. The mean serum piperacillin concentration was 4.0 +/- 1.9 microg/ml at the end of the 4-h on-line HDF session. The concentration of infused piperacillin recovered in the dialysate was 527 +/- 236 mg (26.3% +/- 11.8%). We suggest the replacement of 500 mg of piperacillin after each on-line HDF session.
Oh
Kook-Hwan
KH
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Kim
Chiweon
C
Lee
Hankyu
H
Lee
Hajeong
H
Jung
Ji Yong
JY
Kim
Nam Joong
NJ
Yu
Kyung-Sang
KS
Shin
Kwang-Hee
KH
Jang
In-Jin
IJ
Ahn
Curie
C
D000368:Aged; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D005260:Female; D017583:Hemodiafiltration / Q000379:methods; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D008297:Male; D008875:Middle Aged; D010878:Piperacillin / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D010878:Piperacillin