[Preliminary study on immunosuppressive effects evaluation of biomaterial].
In this paper, an immunosuppression model of immunotoxicity built through applying immunosuppressive agent-cyclophosphamide. Subsequently the changes of some assessment indexes including total amount of lymphocytes and concentration of cytokine TNF-alpha in peripheral blood were observed and were used to evaluate immunotoxicity induced by Medical Heat Vulcanizing Silicone Rubber. The final results showed no immunosuppressive effect caused by this material. The study provide effective and sensitive detection technique for evaluation of medical devices and biomaterials' immunotoxicity.
Xue
Yang
Y
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine/Shanghai Biomaterials Research & Testing Center Shanghai, 200023.
Ding
Ting-ting
TT
Sun
Jiao
J
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D020724:Elastomers / Q000633:toxicity*; D005260:Female; D007166:Immunosuppressive Agents; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008422:Materials Testing; D051379:Mice; D012408:Rubber / Q000633:toxicity; D012828:Silicones / Q000633:toxicity; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D001672:Biocompatible Materials; D020724:Elastomers; D007166:Immunosuppressive Agents; D012828:Silicones; D014409:Tumor Necrosis Factor-alpha; D012408:Rubber