title: The pre-clinical animal model in the translational research of interventional cardiology.
abstract: Scientific discoveries for improvement of human health must be translated into practical applications. Such discoveries typically begin at "the bench" with basic research, then progress to the clinical level. In particular, in the field of interventional cardiology, percutaneous cardiovascular intervention has rapidly evolved from an experimental procedure to a therapeutic clinical setting. Pre-clinical studies using animal models play a very important role in the evaluation of efficacy and safety of new medical devices before their use in human clinical studies. This review provides an overview of the emerging role, results of pre-clinical studies and development, and evaluation of animal models for percutaneous cardiovascular intervention technologies for patients with symptomatic cardiovascular disease.
authors.affiliation: Division of Cardiovascular Medicine, School of Medicine, Stanford University, Stanford, California 94305, USA.
authors.forename: Yoriyasu
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Alan C
authors.initials: AC
authors.lastname: Yeung
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Ikeno
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000517:prevention & control*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D054855:Drug-Eluting Stents; D019317:Evidence-Based Medicine; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D013552:Swine