title: Evidence-based recommendations for the use of topical oxygen therapy in the treatment of lower extremity wounds.
abstract: Topical oxygen therapy provides another tool in the armamentarium of clinicians treating refractory lower extremity wounds. Devices suitable for providing topical oxygen therapy in a clinical setting have recently become available. This article reviews the evidence to justify the use of this treatment modality, including in vitro, preclinical data, and clinical data. It also provides a protocol for how to administer topical oxygen therapy as well as guidance on patient selection and management to optimize outcomes. Randomized controlled trials are not yet reported and clearly necessary. The current body of evidence suggests that topical oxygen therapy may be considered as a second line of therapy for refractory wounds.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA. gayle.gordillo@osumc.edu
authors.forename: Gayle M
authors.initials: GM
authors.lastname: Gordillo
authors.forename: Chandan K
authors.initials: CK
authors.lastname: Sen
mesh_terms: D000287:Administration, Topical; D019317:Evidence-Based Medicine / Q000379:methods*; D006801:Humans; D007869:Leg Injuries / Q000473:pathology / Q000628:therapy*; D010100:Oxygen / Q000008:administration & dosage*; D017410:Practice Guidelines as Topic; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010100:Oxygen