title: [Inhibitive effects of Panax notoginseng saponins on expression of Abeta(1-40), Abeta(1-42) protein in SAMP8's brain].
abstract: OBJECTIVE
  To observe inhibitive effects of Panax notoginseng saponins on expression of Abeta(1-40), Abeta(1-42) protein in SAMP8's brain.
  
  
  METHODS
  Amount of Abeta(1-40), Abeta(1-42 immuno-positive neurons was detected in parietal cortex and hippocamp in their brains under high power lens (40 x) by immunohistochemistry analysis.
  
  
  RESULTS
  PNS could reduce the amount of Abeta(1-40), Abeta(1-42) protein in parietal cortex and hippocamp.
  
  
  CONCLUSIONS
  PNS can reduce the amount of Abeta(1-40), Abeta(1-42) protein in SAMP8's brain.
authors.affiliation: Center of Research & Development of New Drugs, Guangxi Traditional Chinese Medical University, Nanning 530001, China. zhongzg@gxtcmu.edu.cn
authors.forename: Zhen-guo
authors.initials: ZG
authors.lastname: Zhong
authors.forename: Deng-pan
authors.initials: DP
authors.lastname: Wu
authors.forename: Jin-sheng
authors.initials: JS
authors.lastname: Wang
authors.forename: Nai-ping
authors.initials: NP
authors.lastname: Wang
authors.forename: Wen-yan
authors.initials: WY
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Lv
authors.forename: Ze-qiang
authors.initials: ZQ
authors.lastname: Qu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism; D007150:Immunohistochemistry; D051379:Mice; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology; D053723:Panax notoginseng / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012503:Saponins / Q000494:pharmacology*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D018696:Neuroprotective Agents; D012503:Saponins