title: 64-Section multi-detector row CT in the preoperative diagnosis of peritoneal carcinomatosis: correlation with histopathological findings.
abstract: BACKGROUND
  To prospectively investigate the diagnostic accuracy of a 64-section multi-detector row computed tomography (CT) for the detection of peritoneal metastases, with the use of surgery and histopathological findings as the reference standard.
  
  
  METHODS
  The study cohort comprised 18 patients with peritoneal carcinomatosis who underwent multiphasic CT with a 64-section CT, 0-119 days before cytoreductive surgery. Transverse CT images along with isotropic reformatted coronal and sagittal images were prospectively and independently evaluated by one of the five staff radiologists in an unblinded fashion.
  
  
  RESULTS
  The overall sensitivity, specificity, positive, and negative predictive values of CT for the detection of peritoneal metastases were, respectively, 75% (93 of 124 lesions; confidence interval [CI] 68-84), 92% (118 of 128; CI 85-96), 90% (93 of 103; CI 83-95), and 79% (118 of 149; CI 72-86). For lesions 0.5 cm in diameter or larger, CT yielded a mean sensitivity of 89% (77 of 87; CI 75-97), although sensitivity decreased to only 43% (16 of 37; CI 28-56) for lesions <0.5 cm in diameter.
  
  
  CONCLUSIONS
  64-Section CT with the addition of isotropic reformatted coronal and sagittal images is a very effective technique in the detection of peritoneal metastases of 0.5 cm in diameter or larger, although sensitivity decreases remarkably for lesions <0.5 cm in diameter.
authors.affiliation: Department of Radiological Sciences, University of Rome Sapienza, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Marin
authors.forename: Carlo
authors.initials: C
authors.lastname: Catalano
authors.forename: Mahbubeh
authors.initials: M
authors.lastname: Baski
authors.forename: Michele
authors.initials: M
authors.lastname: Di Martino
authors.forename: Daniel
authors.initials: D
authors.lastname: Geiger
authors.forename: Angelo
authors.initials: A
authors.lastname: Di Giorgio
authors.forename: Simone
authors.initials: S
authors.lastname: Sibio
authors.forename: Roberto
authors.initials: R
authors.lastname: Passariello
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D003287:Contrast Media; D003974:Diatrizoate Meglumine; D005260:Female; D006801:Humans; D007479:Iopamidol / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011857:Radiographic Image Interpretation, Computer-Assisted; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D003974:Diatrizoate Meglumine; D007479:Iopamidol