title: Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours.
abstract: OBJECTIVE
  This study aimed to clarify the significance of cluster of differentiation 9 glycoprotein gene expression in human parotid gland tumours.
  
  
  METHODS
  We retrospectively analysed immunohistochemical staining for cluster of differentiation 9 glycoprotein in parotid gland tumours.
  
  
  RESULTS
  Cluster of differentiation 9 glycoprotein was consistently detected in the normal parotid gland. Regarding benign parotid gland tumours, cluster of differentiation 9 glycoprotein was present in 13 of 18 pleomorphic adenomas, in all Warthin tumours tested (21/21) and in all cases of basal cell adenoma tested (four of four). In contrast, positive staining for cluster of differentiation 9 glycoprotein was less often observed in malignant parotid tumours. Cluster of differentiation 9 glycoprotein was present in 11 of 14 mucoepidermoid carcinomas, in two of five acinic cell carcinomas and in two of five adenoid cystic carcinomas.
  
  
  CONCLUSIONS
  There was a statistically significantly reduced expression of cluster of differentiation 9 glycoprotein in malignant parotid gland tumours, compared with benign parotid gland tumours (p < 0.05). These results suggest that a low level of cluster of differentiation 9 glycoprotein expression in parotid gland tumours may be associated with malignancy.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Kurume University School of Medicine, Kurume, Japan. orlkaku@med.kurume-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000235:genetics; D009363:Neoplasm Proteins / Q000032:analysis* / Q000235:genetics; D010306:Parotid Gland / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D010307:Parotid Neoplasms / Q000737:chemistry* / Q000473:pathology; D012189:Retrospective Studies; D060245:Tetraspanin 29
chemical_list: D015703:Antigens, CD; C554869:CD9 protein, human; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D060245:Tetraspanin 29