Kinetics and longevity of antibody response to influenza A H5N1 virus infection in humans.
Anti-H5N1 antibody was determined by microneutralization, hemagglutination inhibition, and Western blotting assays in serial blood samples collected from eight Thai patients, including four fatal cases and four survivors. The antibody was detected as early as 5 days and, typically, with an increase in titer in paired blood at about 15 days after disease onset. The anti-H5 antibody response was long-lasting, for almost 5 years in cases which can be followed that far. In addition, cross-neutralizing activity to related clade 1 viruses was observed.
Kitphati
Rungrueng
R
National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Pooruk
Phisanu
P
Lerdsamran
Hatairat
H
Poosuwan
Siriwan
S
Louisirirotchanakul
Suda
S
Auewarakul
Prasert
P
Chokphaibulkit
Kulkanya
K
Noisumdaeng
Pirom
P
Sawanpanyalert
Pathom
P
Puthavathana
Pilaipan
P
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000917:Antibody Formation; D015153:Blotting, Western; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D005260:Female; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D013785:Thailand; D013997:Time Factors
D000914:Antibodies, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; C109963:hemagglutinin, avian influenza A virus