Polymeric micelles of ammonium palmitoyl glycol chitosan and solubilization of camptothecin.
Chitosan is a polysaccharide possessing biodegradable and biocompatible properties. Chitosan and its derivatives are used as excipients in drug delivery, as mucoadhesive polymers, and as a permeation enhancer for drug delivery in vitro at mucosal epithelia; and micelles of chitosan derivatives are used for solubilization of hydrophobic drug. Twenty-five samples of ammonium palmitoyl glycol chitosan were synthesized after reacting glycol chitosan with palmitic acid N-hydroxysuccinimide and methyl iodide with different concentration of hydrophobic and hydrophilic component. The objective was to identify suitable combinations of hydrophilicity and hydrophobicity which dissolve maximum water-insoluble camptothecin drug. In conclusion, the more hydrophilic and hydrophobic polymers are not suitable for solubilization of camptothecin.
Ranjha
Nazar M
NM
Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. drnazarmranjha@yahoo.com
D000284:Administration, Oral; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry*; D002166:Camptothecin / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D057927:Hydrophobic and Hydrophilic Interactions; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D000644:Quaternary Ammonium Compounds; C114305:palmitoyl glycol chitosan; D048271:Chitosan; D002166:Camptothecin