Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.
Stolk
Lisette
L
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Zhai
Guangju
G
van Meurs
Joyce B J
JB
Verbiest
Michael M P J
MM
Visser
Jenny A
JA
Estrada
Karol
K
Rivadeneira
Fernando
F
Williams
Frances M
FM
Cherkas
Lynn
L
Deloukas
Panos
P
Soranzo
Nicole
N
de Keyzer
Jules J
JJ
Pop
Victor J M
VJ
Lips
Paul
P
Lebrun
Corinne E I
CE
van der Schouw
Yvonne T
YT
Grobbee
Diederick E
DE
Witteman
Jacqueline
J
Hofman
Albert
A
Pols
Huibert A P
HA
Laven
Joop S E
JS
Spector
Tim D
TD
Uitterlinden
André G
AG
D000367:Age Factors; D001943:Breast Neoplasms / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D008593:Menopause / Q000235:genetics*; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D016017:Odds Ratio; D010024:Osteoporosis / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D018433:Twin Studies as Topic; D044465:White People / Q000235:genetics