Deceased donor kidney transplantation from donors with acute renal failure due to rhabdomyolysis.
With the current shortage of solid organs for transplant, the transplant community continues to look for ways to increase the number of organ donors, including extending the criteria for donation. In rhabdomyolysis, the byproducts of skeletal muscle breakdown leak into the circulation resulting in acute renal failure in up to 30% of patients. In nonbrain dead patients, this condition is reversible and most patients recover full renal function. Seven potential donors had rhabdomyolysis with acute renal failure as evidenced by the presence of urine hemoglobin, plasma creatinine kinase levels of greater than five times the normal and elevated creatinine. One donor required dialysis. At our institution, 10 kidneys were transplanted from the seven donors. Two grafts had immediate function, five grafts experienced slow graft function and three grafts had delayed graft function requiring hemodialysis. At a mean of 8.7 months posttransplant (2.4-25.2 months), all patients have good graft function, are off dialysis and have a mean creatinine of 1.3 (0.7-1.8). In conclusion, our experience suggests that rhabdomyolysis with acute renal failure should not be a contraindication for donation, although recipients may experience slow or delayed graft function.
Mekeel
K L
KL
Division of Transplantation, Hepatobiliary and Pancreatic Surgery, Department of Surgery, Mayo Clinic, AZ, USA. mekeel.kristin@mayo.edu
Moss
A A
AA
Mulligan
D C
DC
Chakkera
H A
HA
Hamawi
K
K
Mazur
M J
MJ
Heilman
R L
RL
Reddy
K S
KS
D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D002102:Cadaver; D051799:Delayed Graft Function / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012206:Rhabdomyolysis / Q000150:complications*; D014019:Tissue Donors / Q000600:supply & distribution; D055815:Young Adult