title: Soluble guanylate cyclase: not a dull enzyme.
authors.forename: Guido
authors.initials: G
authors.lastname: Boerrigter
authors.forename: John C
authors.initials: JC
authors.lastname: Burnett
mesh_terms: D001565:Benzoates / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004730:Endothelium, Vascular / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D006162:Guanylate Cyclase / Q000502:physiology*; D006333:Heart Failure / Q000188:drug therapy / Q000201:enzymology; D006418:Heme / Q000502:physiology; D006801:Humans; D009025:Morpholines / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology; D011720:Pyrazoles / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D000071756:Soluble Guanylyl Cyclase; D014665:Vasodilator Agents / Q000494:pharmacology; D014666:Vasomotor System / Q000502:physiology
chemical_list: C423582:3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine; C450679:BAY 41-8543; D001565:Benzoates; D009025:Morpholines; D011720:Pyrazoles; D011725:Pyridines; D011743:Pyrimidines; D018160:Receptors, Cytoplasmic and Nuclear; D014665:Vasodilator Agents; D009569:Nitric Oxide; C480588:BAY 58-2667; D006418:Heme; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase