Neurobrucellosis: report of a rare disease in 20 Iranian patients referred to a tertiary hospital.
We reviewed the clinical manifestations and outcome of 20 cases of neurobrocellosis out of 1375 patients with brucellosis admitted to the infectious diseases ward of a tertiary hospital in Hamedan, Islamic Republic of Iran. Of the 20 cases, 12 had meningitis (acute and subacute), 4 had meningoencephalitis, 2 had myelopathy, 1 had polyradiculopathy and 1 had meningovascular complications manifested by stroke. The most prevalent symptoms were headache (75%), vomiting and fever (50%) and unconsciousness (35%). Among 20 neurobrucellosis patients, 1 died and the other 19 recovered; 14 fully recovered and 5 patients had residual neurological deficits. In endemic areas, the disease should be ruled out in all patients who develop unexplained neurological symptoms.
Ranjbar
M
M
Department of Infectious Diseases, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran. ahmaliver@yahoo.com
Rezaiee
A A
AA
Hashemi
S H
SH
Mehdipour
S
S
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002006:Brucellosis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D019353:Endemic Diseases / Q000706:statistics & numerical data; D005260:Female; D005334:Fever / Q000382:microbiology; D006261:Headache / Q000382:microbiology; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D016920:Meningitis, Bacterial / Q000453:epidemiology* / Q000382:microbiology; D008590:Meningoencephalitis / Q000453:epidemiology / Q000382:microbiology; D008875:Middle Aged; D011128:Polyradiculopathy / Q000453:epidemiology* / Q000382:microbiology; D015995:Prevalence; D035583:Rare Diseases / Q000453:epidemiology / Q000382:microbiology; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013118:Spinal Cord Diseases / Q000453:epidemiology* / Q000382:microbiology; D020521:Stroke / Q000453:epidemiology / Q000382:microbiology; D016896:Treatment Outcome; D014474:Unconsciousness / Q000382:microbiology; D014839:Vomiting / Q000382:microbiology
D000900:Anti-Bacterial Agents