title: Acute renal failure: a rare presentation of hypothyroidism.
abstract: Thyroid hormones affect the function of almost every body organ, and thyroid dysfunction produces a wide range of metabolic disturbances. Severe hypothyroidism is associated with significant effects on the kidney. The pathophysiology is thought to be multifactorial, while the exact mechanism remains unclear. Hypothyroidism as a cause of renal impairment is usually overlooked, leading to unnecessary diagnostic procedures. We describe two patients with acute renal failure due to severe hypothyroidism in whom thyroid hormone substitution therapy led to a significant improvement in renal function.
authors.affiliation: Department of Nephrology, School of Medicine, University of Thessaly, Larissa, Greece.
authors.forename: Vassilios
authors.initials: V
authors.lastname: Liakopoulos
authors.forename: Spyros
authors.initials: S
authors.lastname: Dovas
authors.forename: Theodora
authors.initials: T
authors.lastname: Simopoulou
authors.forename: Sotirios
authors.initials: S
authors.lastname: Zarogiannis
authors.forename: Myrto
authors.initials: M
authors.lastname: Giannopoulou
authors.forename: Panagiota
authors.initials: P
authors.lastname: Kourti
authors.forename: Spiros
authors.initials: S
authors.lastname: Arampatzis
authors.forename: Theodoros
authors.initials: T
authors.lastname: Eleftheriadis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Stefanidis
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged