Primary follicular dendritic cell sarcoma of the thyroid gland coexisting with Hashimoto's thyroiditis.
Follicular dendritic cell (FDC) sarcoma, especially of extranodal origin, is an extremely rare malignancy of FDC origin, with only 1 case previously documented in the thyroid. The authors report the case of a 58-year-old female who presented with a painless mass in her neck. The neoplastic cells expressed monocyte/macrophage-specific marker CD68 (KP-1) and lysozymes and the dendritic cell-associated antigens CD35 and Fascin but was negative for CD1a, CD21, and CD23, most consistent with a diagnosis of FDC sarcoma. BIOMED-2 multiplex polymerase chain reaction analysis showed B-cell clonality in both tumor and its adjacent coexisting Hashimoto's thyroiditis. To the authors' knowledge, this is the first report of a rare entity of FDC sarcoma primarily involving the thyroid gland coexisting with Hashimoto's thyroiditis.
Yu
Lu
L
Pathology, Xi Jing Hospital, 4th Military Medical University, Xi'an, Shaanxi 710032, China.
Yang
Shou Jing
SJ
D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D002999:Clone Cells; D054740:Dendritic Cell Sarcoma, Follicular / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D050031:Hashimoto Disease / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D008875:Middle Aged; D009113:Muramidase; D017463:Receptors, Complement 3b / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013965:Thyroidectomy; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D008840:Microfilament Proteins; D009113:Muramidase; D017463:Receptors, Complement 3b; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C509991:CR1 protein, human; C020324:fascin