A comparison of the neuroprotective efficacy of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.
The neuroprotective effects of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with cyclosarin were studied. The cyclosarin-induced neurotoxicity was monitored using a functional observational battery 24 hours after cyclosarin challenge. The results indicate that a newly developed oxime K156 is able to counteract slightly cyclosarin-induced neurotoxicity while another newly developed oxime K203 is completely ineffective in reducing cyclosarin-induced neurotoxic signs and symptoms. The neuroprotective efficacy of K156 is comparable with commonly used obidoxime and oxime HI-6. Thus, none of the newly developed oximes achieves better neuroprotective efficacy than both commonly used oximes. They are therefore not suitable replacements for antidotal treatment of acute poisonings with cyclosarin.
Kassa
Jirí
J
University of Defence, Faculty of Military Health Sciences, Department of Toxicology, Hradec Králové, Czech Republic. kassa@pmfhk.cz
Karasová
Jana Zd'árová
JZ
Tesarová
Sandra
S
Kuca
Kamil
K
Musílek
Kamil
K
D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity*; D008297:Male; D020258:Neurotoxicity Syndromes / Q000517:prevention & control*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010091:Oximes / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D002619:Chemical Warfare Agents; D009943:Organophosphorus Compounds; D010091:Oximes; C053914:cyclohexyl methylphosphonofluoridate