title: Assessment of cardiac involvement in sarcoidosis by echocardiography.
abstract: The main objective of this study is to determine the prevalence of left ventricular systolic and diastolic dysfunction in patients with chronic sarcoidosis without clinical evidence of heart disease. The study includes 69 chronic sarcoidosis patients, 30 diagnosed by organ biopsy and 39 by clinical history, chest X-ray, high resolution computerized tomography (HRCT) and bronchoalveolar lavage (BAL), without suspected cardiac involvement. The control group consisted of 26 subjects selected from a population of hospital workers. The examination includes 12-lead ECG and echocardiographic examination. The results show that there were no differences in atrial size, left ventricular diameters, wall thickness, left ventricular ejection fraction or endocardial fractional shortening between the sarcoid group and controls. Signs of diastolic dysfunction were found in 33 (55%) patients, however, this group was significantly older than the others and had marginally higher blood pressure. Sarcoid patients had lower midwall fractional shortening (mFS) than controls; patients with diastolic dysfunction also had lower mFS but the difference was not significant. In conclusion, the results demonstrated an absence of left ventricular systolic dysfunction, evaluated by traditional echocardiographic methods, in our chronic sarcoidosis patients and an apparent absence of any relation between left ventricular diastolic dysfunction and sarcoidosis. Lower mFS was found among patients, particularly those with a long history of sarcoidosis. Further analysis is required to evaluate the significance of this index as a potential marker of heart involvement in chronic sarcoidosis.
authors.affiliation: Cardiology U.O., Grosseto Hospital, Grosseto, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Focardi
authors.forename: Andrea
authors.initials: A
authors.lastname: Picchi
authors.forename: Nikolas
authors.initials: N
authors.lastname: Nikiforakis
authors.forename: Elena
authors.initials: E
authors.lastname: Bargagli
authors.forename: Antonella
authors.initials: A
authors.lastname: Fossi
authors.forename: Claudia
authors.initials: C
authors.lastname: Maggiorelli
authors.forename: Sergio
authors.initials: S
authors.lastname: Mondillo
authors.forename: Paola
authors.initials: P
authors.lastname: Rottoli
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016022:Case-Control Studies; D002908:Chronic Disease; D015150:Echocardiography, Doppler / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006325:Heart Atria / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D012507:Sarcoidosis / Q000175:diagnosis / Q000000981:diagnostic imaging*; D013318:Stroke Volume; D013599:Systole; D014057:Tomography, X-Ray Computed; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging; D016277:Ventricular Function, Left