[Distribution of specific IgG subclasses in patients with pertussis and in healthy persons].
OBJECTIVE
To assess level of IgG1, IgG2, IgG3, and IgG4 to complex of antigens of Bordetella pertussis in patients with whooping cough and healthy children and adults.


METHODS
Levels of anti-pertussis IgG subclasses in sera of patients with pertussis and healthy children and adults were measured with solid phase immunoenzyme assay using peroxidase-conjugated monoclonal antibodies to human IgG1, IgG2, IgG3, and IgG4.


RESULTS
In patients with pertussis, IgG1-IgG3-IgG2-IgG4 type of distribution of subclasses with predominance of IgG1 and IgG3 was revealed. In healthy children and adults the character type of subclasses distribution was IgG1-IgG2-IgG4 with absent or low level of IgG3.


CONCLUSIONS
Detection of specific IgG3 mainly in patients with pertussis allows to consider them as a reliable serological sign of pertussis infection.
Zaĭtsev
E M
EM
Mazurova
I K
IK
Petrova
M S
MS
Krasnoproshina
L I
LI
Astakhova
T I
TI
Zakharova
N S
NS
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D000918:Antibody Specificity; D015415:Biomarkers / Q000097:blood; D001886:Bordetella pertussis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000145:classification / Q000276:immunology; D007223:Infant; D008875:Middle Aged; D014917:Whooping Cough / Q000097:blood / Q000276:immunology*
D000907:Antibodies, Bacterial; D015415:Biomarkers; D007074:Immunoglobulin G