title: Polymorphisms in genes involved in vincristine pharmacokinetics or pharmacodynamics are not related to impaired motor performance in children with leukemia.
abstract: BACKGROUND
  Impaired motor performance in children who completed treatment for acute lymphoblastic leukemia (ALL) may be related to polymorphisms of the metabolising gene CYP3A5 or vincristine toxicity related genes MDR-1 and MAPT.
  
  
  METHODS
  Motor performance was measured with the Movement Assessment Battery for Children (movement-ABC). DNA, from mononuclear blood cells was genotyped for CYP3A5, MDR-1 and MAPT polymorphisms.
  
  
  RESULTS
  Motor performance was not significantly affected by CYP3A5*3/*3 and CYP3A5*1*3 genotypes, MDR-1 polymorphisms or MAPT haplotype.
  
  
  CONCLUSIONS
  Our data did not show that CYP3A5, MDR-1 or MAPT polymorphisms are linked to impaired motor performance in children after treatment for ALL.
authors.affiliation: Department of Pediatric Oncology/Hematology, Erasmus MC Sophia Children's Hospital, PO Box 2060, 3000 CB Rotterdam, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Hartman
authors.forename: R H N
authors.initials: RH
authors.lastname: van Schaik
authors.forename: I P
authors.initials: IP
authors.lastname: van der Heiden
authors.forename: M J C
authors.initials: MJ
authors.lastname: Broekhuis
authors.forename: M
authors.initials: M
authors.lastname: Meier
authors.forename: M L
authors.initials: ML
authors.lastname: den Boer
authors.forename: R
authors.initials: R
authors.lastname: Pieters
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D051544:Cytochrome P-450 CYP3A / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D011597:Psychomotor Performance / Q000187:drug effects*; D014750:Vincristine / Q000493:pharmacokinetics*; D016875:tau Proteins / Q000235:genetics*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; C054369:MAPT protein, human; D016875:tau Proteins; D014750:Vincristine; C510164:CYP3A5 protein, human; D051544:Cytochrome P-450 CYP3A