title: Jet lag.
abstract: BACKGROUND
  Jet lag affects most air travellers crossing five or more time zones; it tends to be worse on eastward than on westward flights.
  
  
  METHODS
  We conducted a systematic review and aimed to answer the following clinical question: What are the effects of interventions to prevent or minimise jet lag? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2008 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
  
  
  RESULTS
  We found five systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
  
  
  CONCLUSIONS
  In this systematic review we present information relating to the effectiveness and safety of the following interventions: hypnotics, melatonin, and lifestyle and environmental adaptations.
authors.affiliation: UK Cochrane Centre, Oxford, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Herxheimer
mesh_terms: D064870:Air Travel; D053961:Azabicyclo Compounds / Q000627:therapeutic use; D002110:Caffeine / Q000627:therapeutic use; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D020179:Jet Lag Syndrome / Q000188:drug therapy; D008550:Melatonin / Q000627:therapeutic use; D012463:Saliva
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D002110:Caffeine; D008550:Melatonin