[Antioxidant status and restenosis after stenting of coronary arteries].
OBJECTIVE
To investigate possibility of effect of antioxidant status on severity of restenosis of coronary arteries after transluminal coronary angioplasty with stenting.


METHODS
Men with ischemic heart disease and coronary angiography performed in 6 months after coronary artery stenting with bare stents were included in this study. Coronary angiograms were subjected to quantitative computer analysis. Samples of venous blood were obtained before control angiography. We assessed duration of lag phase of copper induced free radical oxidation of low density lipoproteins (LDL), and measured level of lipoperoxides in LDL, content of malone dialdehyde (MDA) in LDL, activity of superoxide dismutase (SOD), glutathione peroxidase (GP), and erythrocyte catalase.


RESULTS
We revealed positive correlations of lag phase duration and activity of GP with minimal artery diameter 6 months after stenting (r=0.41, p < 0.002 and r=0.24, p < 0.05, respectively), of lipoperoxide level in LDL and MDA content in LDL with degree of stenosis (r=0.32, p < 0.009, and r=0.37, p < 0002, respectively). We also found negative correlations between lag phase duration and GP activity with degree of restenosis (r= - 0.38, p < 0.04, and r= - 0.39, p < 0.001, respectively), level of lipoperoxides in LDL and MDA content in LDL with artery minimal diameter (r= - 0.33, p < 0.007, and r=0.32, p < 0.008, respectively).


CONCLUSIONS
Our study confirms possibility of influence of antioxidant status on degree of coronary artery restenosis in patients after coronary artery stenting.
Kaminnyĭ
A I
AI
Shuvalova
Iu A
IuA
Lankin
V Z
VZ
Piksina
G F
GF
Shirokov
R O
RO
Samko
A N
AN
Kukharchuk
V V
VV
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D000975:Antioxidants / Q000378:metabolism*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D011379:Prognosis; D015607:Stents
D000975:Antioxidants