title: Merobatzelladines A and B, anti-infective tricyclic guanidines from a marine sponge Monanchora sp.
abstract: Merobatzelladines A (1) and B (2) have been isolated from a marine sponge Monanchora sp. as antibacterial constituents. Their structures including relative stereochemistry were determined by interpretation of spectral data. The absolute stereochemistry of merobatzelladine B (2) was elucidated after introduction of the fourth ring system preinstalled with a secondary hydroxyl group to which the modified Mosher method was applied. Merobatzelladines exhibit moderate anti-infective activity against a bacterium and protozoa.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Takishima
authors.forename: Aki
authors.initials: A
authors.lastname: Ishiyama
authors.forename: Masato
authors.initials: M
authors.lastname: Iwatsuki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Otoguro
authors.forename: Haruki
authors.initials: H
authors.lastname: Yamada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006146:Guanidines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000890:Anti-Infective Agents; D006146:Guanidines; D011083:Polycyclic Compounds; C544046:merobatzelladine A; C544045:merobatzelladine B