title: Family support and employment as predictors of smoking cessation success: a randomized, double-blind, placebo-controlled trial of nicotine sublingual tablets in chinese smokers.
abstract: BACKGROUND
  The purpose of this study is to assess social support and demographic factors that influence the success of smoking cessation aided with sublingual nicotine tablets in a Han Chinese population.
  
  
  METHODS
  We randomly allocated 211 Beijing residents who smoked >or= 10 cigarettes a day for at least 1 year into a double-blind, placebo-controlled 3-month randomized smoking cessation trial using sublingual nicotine replacement therapy (NRT). Self-reports of sustained smoking cessation were verified during the study by expired carbon monoxide concentrations and urine-cotinine concentrations. Logistic regression analysis used an intent to treat sample for sociodemographic associations with abstinence and reduction in smoking.
  
  
  RESULTS
  The abstinence rates at the end of treatment for NRT vs. placebo were 52 % vs .19%, and smoking reduction (reduced to at least 50% of baseline) rates for NRT vs. placebo were 43% vs .15% for a total response rate with NRT of 95% for either stopping completely or reducing smoking by 50%. The only factor strongly associated with successful smoking cessation after 3 months of sublingual NRT was being married (adjusted odds ratio 2.18; 95%confidence interval 1.10-4.33). Smoking association, on the other hand, was associated with being married and with employment as a white collar worker (2.24; 1.03 to 4.86).
  
  
  CONCLUSIONS
  These findings suggest the need for a more in-depth examination of the impact of being married and employment as a white collar worker (rather than manual laborer) in order to develop better targeted interventions for improving smoking cessation interventions.
authors.affiliation: National Institute on Drug Dependence, Peking University, Beijing, China.
authors.forename: Hong-Qiang
authors.initials: HQ
authors.lastname: Sun
authors.forename: Song
authors.initials: S
authors.lastname: Guo
authors.forename: Da-Fang
authors.initials: DF
authors.lastname: Chen
authors.forename: Zuo-Ning
authors.initials: ZN
authors.lastname: Jiang
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Di
authors.forename: Fu-De
authors.initials: FD
authors.lastname: Yang
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Zhang
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Kosten
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D002248:Carbon Monoxide / Q000032:analysis; D002681:China; D003367:Cotinine / Q000652:urine; D004311:Double-Blind Method; D005195:Family Relations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage*; D018722:Nicotinic Agonists / Q000008:administration & dosage*; D016540:Smoking Cessation / Q000379:methods* / Q000523:psychology; D000074606:Smoking Prevention; D012944:Social Support; D017132:Workplace / Q000523:psychology
chemical_list: D018722:Nicotinic Agonists; D009538:Nicotine; D002248:Carbon Monoxide; D003367:Cotinine