title: Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect.
abstract: Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome c is essential for the bystander effect.
authors.affiliation: State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing 100871, People's Republic of China.
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Zhu
authors.forename: P
authors.initials: P
authors.lastname: Huang
authors.forename: L
authors.initials: L
authors.lastname: Tong
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: G
authors.initials: G
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Mei
authors.forename: A
authors.initials: A
authors.lastname: Xu
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis; D024201:Bystander Effect / Q000528:radiation effects*; D018929:Cell Culture Techniques; D018920:Coculture Techniques; D045304:Cytochromes c / Q000378:metabolism*; D005720:Gamma Rays; D053078:Membrane Potential, Mitochondrial; D051379:Mice; D018345:Mice, Knockout; D015162:Micronucleus Tests; D008928:Mitochondria / Q000201:enzymology* / Q000473:pathology / Q000528:radiation effects*; D009569:Nitric Oxide / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D045304:Cytochromes c