title: Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
abstract: The discovery and optimization of a series of potent PPARdelta full agonists with partial agonistic activity against PPARgamma is described.
authors.affiliation: Department of Chemistry, Amgen, 1120 Veterans Blvd., South San Francisco, CA 94080, USA. rconnors@amgen.com
authors.forename: Richard V
authors.initials: RV
authors.lastname: Connors
authors.forename: Zhulun
authors.initials: Z
authors.lastname: Wang
authors.forename: Martin
authors.initials: M
authors.lastname: Harrison
authors.forename: Alex
authors.initials: A
authors.lastname: Zhang
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wanska
authors.forename: Steve
authors.initials: S
authors.lastname: Hiscock
authors.forename: Brian
authors.initials: B
authors.lastname: Fox
authors.forename: Michael
authors.initials: M
authors.lastname: Dore
authors.forename: Marc
authors.initials: M
authors.lastname: Labelle
authors.forename: Athena
authors.initials: A
authors.lastname: Sudom
authors.forename: Sheree
authors.initials: S
authors.lastname: Johnstone
authors.forename: Jinsong
authors.initials: J
authors.lastname: Liu
authors.forename: Nigel P C
authors.initials: NP
authors.lastname: Walker
authors.forename: Anne
authors.initials: A
authors.lastname: Chai
authors.forename: Karen
authors.initials: K
authors.lastname: Siegler
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Peter
authors.initials: P
authors.lastname: Coward
mesh_terms: D000818:Animals; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D047494:PPAR delta / Q000819:agonists* / Q000378:metabolism; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D047494:PPAR delta; D047495:PPAR gamma; D013844:Thiazoles