title: Novel chemotherapy approaches for cervical cancer.
abstract: Cancer of the cervix is the second most common malignancy among women worldwide. The last 20 years have lead to numerous advances in the medical management of locally advanced cervical cancer, including preventive vaccination, chemoradiation, and neoadjuvant chemotherapy. The treatment of metastatic disease is palliative at best. Platinum-based chemotherapy remains the standard of care for inoperable patients who have recurrent disease. However, because most patients initially receive concomitant platinum-based therapy with radiation, many recurrent tumors are refractory to platinum. The use of novel therapeutic approaches targeted to the carcinogenic processes that leads to the ontogenesis of cervical cancer should be promoted in clinical studies to improve patient outcomes.
authors.affiliation: Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico, USA. cverschraegen@salud.unm.edu
authors.forename: Sujana
authors.initials: S
authors.lastname: Movva
authors.forename: Lorna
authors.initials: L
authors.lastname: Rodriguez
authors.forename: Hugo
authors.initials: H
authors.lastname: Arias-Pulido
authors.forename: Claire
authors.initials: C
authors.lastname: Verschraegen
mesh_terms: D000465:Algorithms; D000971:Antineoplastic Combined Chemotherapy Protocols; D001691:Biological Therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008954:Models, Biological; D020360:Neoadjuvant Therapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*