The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy.
OBJECTIVE
Interleukin-1beta (IL-1beta) polymorphisms are associated with peptic ulcer and atrophic gastritis. This study aimed to examine effects of corpus atrophy and the genotypes of genes related to peptic ulcer, including IL-1beta, on risk of aspirin ulcer.


METHODS
232 patients taking 100 mg of aspirin for cardiovascular diseases, of whom 40 had peptic ulcer, were enrolled. IL1beta, interleukin-1 receptor antagonist (IL-1RN), tumor necrosis factor (TNF)-alpha, cyclooxygenase (COX)-1, cytochrome p450 2C9 (CYP2C9), UDP-glucuronosyltransferase (UGT1A6) genotypes were determined, and serum pepsinogen levels were measured.


RESULTS
The polymorphisms of IL-1beta-511/-31 were significantly associated with peptic ulcer, but other genotypes were not. Serum pepsinogen I and II levels and I/II ratio were significantly higher in the ulcer group than in the non-ulcer group. Taking PPI [adjusted odds ratio (OR), 0.09; 95% confidence interval (CI), 0.02-0.39], pepsinogen I of less than 50 ng/ml (OR, 0.24; 95% CI, 0.10-0.56) and IL-1beta-511 T carrier (OR, 0.42; 95% CI, 0.18-0.93) were significantly associated with peptic ulcer.


CONCLUSIONS
Hypoacidity related to corpus atrophy as well as taking PPI seems to be preventively associated with development of peptic ulcer among low dose aspirin users.
Shiotani
Akiko
A
Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. shiotani@med.kawasaki-m.ac.jp
Sakakibara
Takashi
T
Yamanaka
Yoshiyuki
Y
Nishi
Ryuji
R
Imamura
Hiroshi
H
Fujita
Minoru
M
Tarumi
Ken-ichi
K
Kamada
Tomoari
T
Hata
Jiro
J
Haruma
Ken
K
D000368:Aged; D001241:Aspirin / Q000009:adverse effects*; D001284:Atrophy / Q000150:complications; D051545:Cyclooxygenase 1 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D010435:Pepsinogens / Q000097:blood*; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic
D053583:Interleukin-1beta; D010435:Pepsinogens; D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human; D001241:Aspirin