[Structure of risk factors, damages of target organs, and metabolic changes in patients with arterial hypertension of various age groups].
AIM of the study consisted in investigation of structure of risk factors and pathological changes of morphological and functional parameters of cardiovascular system, parameters of carbohydrate and lipid metabolism and their relationship with arterial hypertension (AH) in age groups younger than 35 years, 35 - 55, and older than 55 years. We examined 91 patients with AH and 158 subjects with normal blood pressure (BP). Both groups were divided into 3 age groups: < 35, 35 - 55, > 55 years. Examination included study of anamnesis, investigation of anthropometric parameters, indices of lipid and carbohydrate metabolism, determination of signs of involvement of large vessels and the heart, assessment of parameters of left ventricular diastolic function. Genotyping of a row of polymorphisms of renin angiotensin aldosterone system was also carried out. Association of each pathological sign with the presence of AH was calculated according to value of odds ratio.


RESULTS
Presence of AH in all selected age groups was significantly associated with signs of metabolic syndrome (except hypercholesterolemia for subjects before 35 years) and symptoms of involvement of large vessels and the heart (except diastolic left ventricular dysfunction according to IVRT criterion for subjects younger than 35 and older than 55 years). Contrary to persons with normal BP detection of heredity burdened with cardiovascular diseases was significantly associated with presence of AH in patients aged 35 - 55 years. Hypertriglyceridemia, lowering of low density lipoprotein cholesterol level, increased thickness of intima media complex of common carotid artery, as well as elevation of rate of propagation of pulse wave along elastic arteries were characterized by about equal degree of association with the presence of AH in all three age groups. Variants of polymorphisms of genes encoding elements of renin angiotensin aldosterone system (AGTT174M, ACE, AGTR1) were associated with presence of AH in younger and middle age groups.
Boĭtsov
S A
SA
Urinskiĭ
A M
AM
Kuznetsov
R L
RL
Pozdniakov
Iu M
IuM
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002241:Carbohydrates / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D016017:Odds Ratio; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology
D002241:Carbohydrates; D008055:Lipids