Role of immunohistochemistry in the diagnosis of lung cancer.
The role of immunohistochemistry is to recognize antigens and, consequently, to identify and classify specific cells within a cell population whose morphology is heterogenous or apparently homogenous. The visualization of the antigen-antibody complex is made possible through the addition of either a fluorochrome conjugate or an enzyme to the antibody, which is then viewed under microscopy. Immunohistochemistry can be used in the routine diagnosis of lung cancer, in order to identify biological markers (diagnostic and prognostic). The essential immunohistochemistry panels will be discussed in this review.
Capelozzi
Vera Luiza
VL
Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. vcapelozzi@lim05.fm.usp.br
D014408:Biomarkers, Tumor / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology / Q000473:pathology*; D018773:Genes, erbB-1 / Q000276:immunology; D018734:Genes, erbB-2 / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology*; D020780:Matrix Metalloproteinase 9 / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53; D042461:Vascular Endothelial Growth Factor A; D020780:Matrix Metalloproteinase 9