title: Apolipoprotein E limits oxidative stress-induced cell dysfunctions in human adipocytes.
abstract: Oxidative stress in adipose tissue constitutes a pathological process involved in obesity-linked metabolic disorders. Apolipoprotein E (apoE), which exhibits antioxidant properties in plasma and brain, is highly produced by adipose tissue and adipocytes. In this study, we investigated the role of apoE in the human adipocyte response to oxidative stress. We first demonstrated that apoE secretion by adipocytes was stimulated by oxidative stress. We also observed that apoE overexpression protected adipocytes from hydrogen peroxide-induced damages, by mitigating intracellular oxidation and exerting extracellular antioxidant properties. Our findings clearly show a novel antioxidant role for apoE in adipose tissue.
authors.affiliation: Laboratoire de Biochimie et Génétique Moléculaire (LBGM), Université de La Réunion, Saint Denis Messag, La Réunion, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Tarnus
authors.forename: Hanny
authors.initials: H
authors.lastname: Wassef
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Carmel
authors.forename: Philippe
authors.initials: P
authors.lastname: Rondeau
authors.forename: Marjolaine
authors.initials: M
authors.lastname: Roche
authors.forename: Jean
authors.initials: J
authors.lastname: Davignon
authors.forename: Lise
authors.initials: L
authors.lastname: Bernier
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bourdon
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D052242:Adiponectin / Q000235:genetics; D000975:Antioxidants / Q000378:metabolism; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D015870:Gene Expression; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity; D020738:Leptin / Q000235:genetics; D018384:Oxidative Stress; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D014162:Transfection
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D000975:Antioxidants; D001057:Apolipoproteins E; D020738:Leptin; D011994:Recombinant Proteins; D006861:Hydrogen Peroxide