title: Aminoquinoline derivatives with antiproliferative activity against melanoma cell line.
abstract: The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC(50)=0.77 and 0.79microM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.
authors.affiliation: Life Sciences Research Division, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea.
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Nam
authors.forename: Hwan
authors.initials: H
authors.lastname: Kim
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Oh
authors.forename: So Ha
authors.initials: SH
authors.lastname: Lee
authors.forename: Seung Joo
authors.initials: SJ
authors.lastname: Cho
authors.forename: Tae Bo
authors.initials: TB
authors.lastname: Sim
authors.forename: Jung-Mi
authors.initials: JM
authors.lastname: Hah
authors.forename: Dong Jin
authors.initials: DJ
authors.lastname: Kim
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Yoo
mesh_terms: D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008545:Melanoma / Q000188:drug therapy
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents