title: 1,n-glycols as dialdehyde equivalents in iridium-catalyzed enantioselective carbonyl allylation and iterative two-directional assembly of 1,3-polyols.
abstract: Unstable? We're able! 1,n-Glycols serve as synthetic equivalents to unstable dialdehydes in two-directional carbonyl allylation from the alcohol oxidation level under iridium-catalyzed transfer hydrogenation conditions. Iterative asymmetric allylation employing 1,3-propanediol enables the rapid assembly of protected 1,3-polyol substructures with exceptional levels of stereocontrol.
authors.affiliation: University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station-A5300, Austin, TX 78712-1167, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lu
authors.forename: In Su
authors.initials: IS
authors.lastname: Kim
authors.forename: Abbas
authors.initials: A
authors.lastname: Hassan
authors.forename: David J
authors.initials: DJ
authors.lastname: Del Valle
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D010084:Oxidation-Reduction; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D011108:Polymers; C024617:polyol; D007495:Iridium