Identification of the toxic trigger  in mushroom poisoning.
We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.
Matsuura
Masanori
M
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, Japan.
Saikawa
Yoko
Y
Inui
Kosei
K
Nakae
Koichi
K
Igarashi
Masayuki
M
Hashimoto
Kimiko
K
Nakata
Masaya
M
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000633:toxicity; D045744:Cell Line, Tumor; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000633:toxicity; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D009145:Mushroom Poisoning / Q000209:etiology*; D009183:Mycotoxins / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000633:toxicity; D012206:Rhabdomyolysis / Q000209:etiology*
D002264:Carboxylic Acids; D003521:Cyclopropanes; D009183:Mycotoxins; C545431:cycloprop-2-ene carboxylic acid