title: A new anorexigenic protein, nesfatin-1.
abstract: An anorexigenic peptide, nesfatin-1 was found in rat hypothalamus, and its expression in the paraventricular nucleus of the hypothalamus was reduced by starvation. Intracerebroventricular administration dose-dependently inhibited food intake for 6 h in male Wistar and leptin resistant, Zucker fatty rats. There may be a crosstalk between nesfatin-1 pathway and melanocortin pathway in the brain. Nesfatin-1 neurons co-express with oxytocin, vasopressin and melanin concentrating hormone in the hypothalamus. Intraperitoneal administration of nesfatin-1 and its mid-segment dose-dependently inhibited food intake for 3 h. Mid-segment of nesfatin-1 decreased food intake under leptin-resistant animal models of obesity. Intraperitoneal administration of the mid-segment of nesfatin-1 increased proopiomelanocortin and cocain- and amphetamine-related peptide mRNA expression in the nucleus of the solitary tract, but not in arcuate nucleus of the hypothalamus. In this review, we summarized recent progress in the research about the possible mechanism of nesfatin-1-induced anorexia.
authors.affiliation: aDepartment of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan. hshimizu@showa.gunma-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Aya
authors.initials: A
authors.lastname: Ohsaki
authors.forename: Sinsuke
authors.initials: S
authors.lastname: Oh-I
authors.forename: Shuichi
authors.initials: S
authors.lastname: Okada
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000818:Animals; D000855:Anorexia / Q000503:physiopathology*; D001067:Appetite Depressants / Q000494:pharmacology; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D007276:Injections, Intraventricular; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology / Q000502:physiology*; D000080866:Nucleobindins; D051381:Rats; D017208:Rats, Wistar; D011924:Rats, Zucker
chemical_list: D001067:Appetite Depressants; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C000630652:Nucb1 protein, rat; D000080866:Nucleobindins