title: A functional insertion/deletion polymorphism in the promoter region of the NFKB1 gene increases susceptibility for prostate cancer.
abstract: Among men, cancers of the prostate, lung and bronchus, and colon and rectum account for about 50% of all newly diagnosed cancers, and prostate cancer alone accounts for about 25% of incident cases. Nuclear factor-kappaB (NF-kappaB)-activation plays a critical role in prostate cancer by NF-kappaB inhibitor kinase beta pathway-mediated inflammatory-induced tumorigenesis. A functional insertion/deletion polymorphism (-94 insertion/deletion ATTG) in the promoter of the NFKB1 gene, which encodes the p50 subunit of NF-kappaB, was identified recently. A total of 117 prostate cancer patients and 143 control subjects were recruited in this study. The NFKB1 -94 insertion/deletion ATTG genotype was determined using polymerase chain reaction-polyacrylamide gel electrophoresis. The frequency of the ATTG(2) allele in prostate cancer patients was significantly higher than that in the controls (63.7 vs. 54.5%; P=0.035, OR=1.461). Prostate cancer patients with a history of prostatitis have a 2.275 times higher risk for prostate cancer, compared to the control group (P=0.001). The functional NFKB1 promoter polymorphism is associated with increased risk of prostate cancer.
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Kunjie
authors.initials: K
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Zeng
authors.forename: Hong
authors.initials: H
authors.lastname: Bu
authors.forename: Hong
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D004251:DNA Transposable Elements; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D009367:Neoplasm Staging; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D011472:Prostatitis / Q000235:genetics; D012016:Reference Values; D012307:Risk Factors; D017384:Sequence Deletion
chemical_list: D004251:DNA Transposable Elements; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; D017430:Prostate-Specific Antigen