Atrial natriuretic peptide and brain natriuretic peptide release in human essential hypertension.
Hypertension is associated with an increase in vasoactive peptides, but conflicting results are reported concerning their causes of elevation. In this study, cardiac vasodilator hormones atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), and vasoconstrictor hormones (renin, aldosterone, cortisol, metanephrins) were determined in 36 hypertensive subjects (HT) without left ventricular hypertrophy (LVH), 19 healthy subjects without family hypertension (NTFN) and 35 healthy subjects with family hypertension (NTFH). Plasma levels of ANP and BNP were significantly higher (p<0.04) in HT subjects (28.1 +/- 6.1 and 22.7 +/- 6.8 pg/ml) compared to NTFN (13.4 +/- 3.3 and 6.1 +/- 1.5 pg/ml) and NTFH (12.5 +/- 1.4 and 7.2 +/- 1.3 pg/ml) subjects, respectively. No significant differences were observed in ANP and BNP concentrations between NTFN and NTFH. Measurement of vasoconstrictor hormones showed no significant differences between the three groups. Plasma ANP and BNP concentrations were significantly correlated in both HT (r=0.73; P<0.001), NTFN (r=0.71; P<0.002) and NTFH (r=0.53; P<0.003) subjects. ANP values were significantly related to systolic blood pressure (r=0.34; P<0.05) in the HT group while BNP values were not. The echocardiographic findings were not correlated with ANP or BNP in the HT patients. This suggests that natriuretic peptides increase is related to the blood pressure elevation rather than LVH to reduce detrimental high BP effects.
Soualmia
Hayet
H
LR99ES11 Research Laboratory and Department of Biochemistry, Rabta Hospital, Tunis, Tunisia. hayetsoualmia@yahoo.fr
Ayadi
Ilhem
I
Omar
Souheil
S
Feki
Moncef
M
Drissa
Habiba
H
Mebazaa
Abderraouf
A
Kaabachi
Naziha
N
D000704:Analysis of Variance; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D004562:Electrocardiography; D006801:Humans; D006973:Hypertension / Q000097:blood*; D017379:Hypertrophy, Left Ventricular / Q000097:blood; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D014661:Vasoconstriction; D014664:Vasodilation
D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor