title: Head-to-head comparison of coronary plaque evaluation between multislice computed tomography and intravascular ultrasound radiofrequency data analysis.
abstract: OBJECTIVE
  The purpose of this study was to perform a head-to-head comparison of plaque observations with multislice computed tomography (MSCT) to virtual histology intravascular ultrasound (VH IVUS).
  
  
  BACKGROUND
  The VH IVUS allows in vivo coronary plaque characterization with high spatial resolution. Noninvasively, plaques may be evaluated with MSCT, but limited data are available.
  
  
  METHODS
  A total of 50 patients underwent 64-slice MSCT followed by VH IVUS. The Agatston score was evaluated on MSCT in coronary segments where IVUS was performed. Plaques were classified on MSCT as noncalcified, mixed, and calcified. Four plaque components (fibrotic, fibro-fatty, and necrotic core tissues and dense calcium) were identified on VH IVUS, and the presence of thin-cap fibroatheroma was evaluated.
  
  
  RESULTS
  A moderate correlation was observed between the Agatston score and calcium volume on VH IVUS (r = 0.69, p < 0.0001). In total, 168 coronary plaques were evaluated (48 [29%] noncalcified, 71 [42%] mixed, 49 [29%] calcified). As compared with calcified plaques, noncalcified plaques contained more fibrotic (60.90 +/- 9.21% vs. 54.60 +/- 8.33%, p = 0.001) and fibro-fatty tissues (28.11 +/- 13.03% vs. 21.37 +/- 9.75%, p = 0.006) on VH IVUS. Mixed and calcified plaques contained more dense calcium (7.61 +/- 8.94% vs. 2.68 +/- 3.01%, p = 0.001; 10.18 +/- 6.71% vs. 2.68 +/- 3.01%, p < 0.0001, respectively). Thin-cap fibroatheromas were most frequently observed in mixed plaques as compared with noncalcified and calcified plaques (32%, 13%, 8%, p = 0.002, respectively).
  
  
  CONCLUSIONS
  A good correlation was observed between calcium quantification on MSCT and VH IVUS. In addition, plaque classification on MSCT paralleled relative plaque composition on VH IVUS, although VH IVUS provided more precise plaque characterization. Mixed plaques on MSCT were associated with high-risk features on VH IVUS.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
authors.forename: Gabija
authors.initials: G
authors.lastname: Pundziute
authors.forename: Joanne D
authors.initials: JD
authors.lastname: Schuijf
authors.forename: J Wouter
authors.initials: JW
authors.lastname: Jukema
authors.forename: Isabel
authors.initials: I
authors.lastname: Decramer
authors.forename: Giovanna
authors.initials: G
authors.lastname: Sarno
authors.forename: Piet K
authors.initials: PK
authors.lastname: Vanhoenacker
authors.forename: Johannes H C
authors.initials: JH
authors.lastname: Reiber
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Schalij
authors.forename: William
authors.initials: W
authors.lastname: Wijns
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging*; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D005355:Fibrosis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional; D014584:User-Computer Interface