title: Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge.
abstract: Pilomatricoma is believed to differentiate towards the hair matrix and hair cortex. To elucidate the origin of differentiation in pilomatricoma, we studied the expression of epithelial keratin (K) and filaggrin (filament aggregating protein) in pilomatricoma. An immunohistochemical study has been made of 53 cases of pilomatricoma using 10 monospecific anti-keratin antibodies and anti-filaggrin antibody. Basophilic cells, transitional cells and shadow cells did not react with epithelial keratins and filaggrin antibodies as well as hair matrix and hair cortex. Instead, infundibular-type epithelium was positive for K1, K10 and filaggrin. Epithelium showing trichilemmal keratinization was positive for K14 and K16. The hair bulge-like structure was positive for K19. The differentiation of pilomatricoma is diversified, and is heterogeneous in epithelial keratin and filaggrin expression. Our results for keratin and filaggrin expression suggested that pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kurokawa
authors.forename: Kei-ichi
authors.initials: K
authors.lastname: Yamanaka
authors.forename: Yuko
authors.initials: Y
authors.lastname: Senba
authors.forename: Hitomi
authors.initials: H
authors.lastname: Sugisaki
authors.forename: Airo
authors.initials: A
authors.lastname: Tsubura
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Kimura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mizutani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D000091344:Filaggrin Proteins; D006197:Hair / Q000378:metabolism*; D006201:Hair Diseases / Q000378:metabolism / Q000473:pathology; D018859:Hair Follicle / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007633:Keratins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018296:Pilomatrixoma / Q000378:metabolism* / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007633:Keratins