Vertical arrays of nanofluidic channels fabricated without nanolithography.
Vertical arrays of sealed nanofluidic channels, in which both cross-sectional dimensions are controllable down to 10 nm, were fabricated by selective side etching of a SiGe heterostructure comprised of layers of alternating Ge fractions. Capillary filling of these nanochannel arrays with fluorescent dye solutions was investigated using a confocal microscope. The feasibility of using nanochannels for size-based separation of biomolecules was demonstrated by imaging aggregates of tagged amyloid-beta peptide. The ability to integrate a large number of nanochannels shows promise for high throughput applications involving lab-on-a-chip systems.
Sordan
Roman
R
L-NESS, Dipartimento di Fisica, Politecnico di Milano, Via Anzani 42, 22100, Como, Italy. roman.sordan@como.polimi.it
Miranda
Alessio
A
Traversi
Floriano
F
Colombo
Davide
D
Chrastina
Daniel
D
Isella
Giovanni
G
Masserini
Massimo
M
Miglio
Leo
L
Kern
Klaus
K
Balasubramanian
Kannan
K
D016229:Amyloid beta-Peptides / Q000648:ultrastructure; D005456:Fluorescent Dyes / Q000737:chemistry; D005857:Germanium / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D018613:Microscopy, Confocal; D036103:Nanotechnology / Q000295:instrumentation*; D012825:Silicon / Q000737:chemistry; D014741:Video Recording
D016229:Amyloid beta-Peptides; D005456:Fluorescent Dyes; D005857:Germanium; D012825:Silicon