title: Severe acute tumor lysis syndrome in patients with germ-cell tumors.
abstract: Germ-cell tumors are a high-proliferative type of cancer that may evolve to significant bulky disease. Tumor lysis syndrome is rarely reported in this setting. The reports of three patients with germ-cell tumors who developed severe acute tumor lysis syndrome following the start of their anticancer therapy are presented. All patients developed renal dysfunction and multiorgan failure. Patients with extensive germ-cell tumors should be kept on close clinical and laboratory monitoring. Physicians should be aware of this uncommon but severe complication and consider early admission to the intensive care unit for the institution of measures to prevent acute renal failure.
authors.affiliation: Intensive Care Unit, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil.
authors.forename: Guilherme Alvarenga
authors.initials: GA
authors.lastname: Feres
authors.forename: Jorge Ibrain Figueira
authors.initials: JI
authors.lastname: Salluh
authors.forename: Carlos Gil
authors.initials: CG
authors.lastname: Ferreira
authors.forename: Marcio
authors.initials: M
authors.lastname: Soares