title: Effect of combined treatment methods on quality of life in patients with pancreatic cancer.
abstract: We aimed to analyze the effect of combined treatment methods on quality of life (QoL) in patients diagnosed with pancreatic cancer. Therefore, we prospectively analyzed 30 patients with unresectable, without distant metastases, pancreatic cancer. Patients were randomized to 1 of 2 treatment arms: radiotherapy with 5-fluorouracil or radiotherapy with gemcitabine. QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) questionnaire in both treatment groups. QoL was evaluated before and after treatment. We found that that both concomitant chemoradiation methods have similar impact on QoL in patients with unresectable pancreatic cancer.
authors.affiliation: Department of Internal Medicine, General Hospital of Cos, Cos, Greece. panheras@yahoo.com
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Heras
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kritikos
authors.forename: Antonios
authors.initials: A
authors.lastname: Hatzopoulos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kritikos
authors.forename: Stefanos
authors.initials: S
authors.lastname: Karagiannis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Mitsibounas
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D005472:Fluorouracil; D000093542:Gemcitabine