Insights into defibrotide: an updated review.
Defibrotide is a polydisperse oligonucleotide with antiatherosclerotic, anti-inflammatory, anti-ischaemic, pro-fibrinolytic and antithrombotic actions without significant systemic anticoagulant effects. It has been used in the treatment of various cardiovascular disorders, and especially in endothelial complications of allogeneic stem-cell transplantation. We reviewed the published work for the mechanism of action and clinical use of defibrotide to consolidate data and to describe new applications of this drug. We reviewed the most relevant papers on defibrotide published from November 1982 to January 2008. (selected through PubMed), and used recent meeting abstracts as sources for this review. Reports have suggested that defibrotide has clinical efficacy for treatment and prophylaxis of hepatic sinusoidal obstruction syndrome occurring after stem-cell transplantation. Animal models have clearly shown the potential antineoplastic effect of this drug. Further clinical investigations are needed to clarify this new application.
Morabito
F
F
Unità Operativa Complessa di Ematologia, Dipartimento di Medicina Interna, Azienda Ospedaliera di Cosenza, Viale della Repubblica, Cosenza 87100, Italy. fortunato_morabito@tin.it
Gentile
M
M
Gay
F
F
Bringhen
S
S
Mazzone
C
C
Vigna
E
E
Musto
P
P
Di Raimondo
F
F
Palumbo
A
A
D006504:Hepatic Veno-Occlusive Disease / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D009838:Oligodeoxyribonucleotides / Q000009:adverse effects / Q000627:therapeutic use*
D009838:Oligodeoxyribonucleotides