Pharmacokinetics and bioavailability of cinnamic acid after oral administration of Ramulus Cinnamomi in rats.
The pharmacokinetics of cinnamic acid (CA) after oral administration of Decoction of Ramulus Cinnamomi (RC) 7.4 g/kg [containing CA 7.62 x 10(-5) mol/kg and cinnamaldehyde (CNMA) 1.77 x 10(-5) mol/kg], was compared with that after oral administration of pure CA 7.62 x 10(-5) mol/kg in rats. Plasma concentrations of CA and hippuric acid (HA) were determined by HPLC. Pharmacokinetic parameters were calculated from the plasma concentration-time data. CA was quickly absorbed and then metabolized mainly into HA. The AUC(0-t) and AUC(0-infinity)) of CA were higher in RC group than those in pure CA group and the bioavailability of CA from RC was higher than that from pure CA. After ig administration of 3.79 x 10(-4) mol/kg, CNMA was at least partially metabolized into CA in stomach and small intestine and almost completely metabolized into CA in liver before it is absorbed into blood in rats. The results showed that plasma CA in RC group might partly come from transformation of CNMA in RC.
Chen
Yingrong
Y
Laboratory of Pharmacokinetics, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
Ma
Yueming
Y
Ma
Wei
W
D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D002934:Cinnamates / Q000493:pharmacokinetics*; D002935:Cinnamomum zeylanicum / Q000737:chemistry*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006626:Hippurates / Q000097:blood; D007202:Indicators and Reagents; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results
D002934:Cinnamates; D006626:Hippurates; D007202:Indicators and Reagents; D010936:Plant Extracts; C029010:cinnamic acid; C030514:hippuric acid