title: Observer variation of magnetic resonance imaging and diffusion weighted imaging in pelvic lymph node detection.
abstract: OBJECTIVE
  Conventional MRI and the recently developed diffusion weighted imaging (DWI) technique both are being used for the detection of pelvic lymph node metastasis in gynaecologic cancers. Little is known about the reproducibility of DWI. This study assesses the reproducibility of pelvic lymph node detection by conventional MRI and DWI.
  
  
  METHODS
  17 patients with gynaecological malignancies eligible for curative surgery were selected as population of interest. They had undergone preoperative conventional MRI and DWI on a 3.0T MR scanner. All images were evaluated by two experienced radiologists. Inter- and intra-observer agreements were assessed, and whether lymph node size and region were related to reproducibility. Differences were tested by Chi-square statistics.
  
  
  RESULTS
  The reproducibility ranged between 42% and 65% for the two observers and for the two imaging tests, conventional MRI and DWI. Higher percentages of agreement were found for larger lymph nodes, i.e. for long as well as short axis diameter exceeding 5mm. Also, agreement was better for lymph nodes in the external iliac region and the obturator region compared to detection of lymph nodes in the common iliac area. Results for the newer technique, DWI, were comparable to the results of the more conventional MRI sequences.
  
  
  CONCLUSIONS
  Reproducibility of MRI and DWI in the detection of pelvic lymph nodes in patients with a gynaecological malignancy was similar. For lymph nodes exceeding 5mm in both long and short axis diameter the agreement was considerably better than for smaller nodes.
authors.affiliation: Department of Gynaecology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. w.klerkx@umcutrecht.nl
authors.forename: Wenche M
authors.initials: WM
authors.lastname: Klerkx
authors.forename: Willem M
authors.initials: WM
authors.lastname: Mali
authors.forename: A
authors.initials: A
authors.lastname: Peter Heintz
authors.forename: Gerard A
authors.initials: GA
authors.lastname: de Kort
authors.forename: Taro
authors.initials: T
authors.lastname: Takahara
authors.forename: Petra H
authors.initials: PH
authors.lastname: Peeters
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D015588:Observer Variation; D010051:Ovarian Neoplasms / Q000473:pathology*; D015203:Reproducibility of Results; D002583:Uterine Cervical Neoplasms / Q000473:pathology*