title: A probabilistic MR atlas of the human cerebellum.
abstract: The functional organization of the cerebellum is reflected in large part by the unique afferent and efferent connectivity of the individual cerebellar lobules. This functional diversity on a relatively small spatial scale makes accurate localization methods for human functional imaging and anatomical patient-based research indispensable. Here we present a probabilistic atlas of the cerebellar lobules in the anatomical space defined by the MNI152 template. We separately masked the lobules on T1-weighted MRI scans (1 mm isotropic resolution) of 20 healthy young participants (10 male, 10 female, average age 23.7 yrs). These cerebella were then aligned to the standard or non-linear version of the whole-brain MNI152 template using a number of commonly used normalization algorithms, or to a previously published cerebellum-only template (Diedrichsen, J., 2006. A spatially unbiased atlas template of the human cerebellum. NeuroImage 33, 127-138.). The resulting average overlap was higher for the cerebellum-only template than for any of the whole-brain normalization methods. The probabilistic maps allow for the valid assignment of functional activations to specific cerebellar lobules, while providing a quantitative measure of the uncertainty of such assignments. Furthermore, maximum probability maps derived from these atlases can be used to define regions of interest (ROIs) in functional neuroimaging and neuroanatomical research. The atlas, made freely available online, is compatible with a number of widely used analysis packages.
authors.affiliation: Wolfson Centre for Cognitive and Clinical Neuroscience, School of Psychology, Adeilad Brigantia, University of Wales Bangor, Gwynedd LL572AS, UK. j.diedrichsen@bangor.ac.uk
authors.forename: Jörn
authors.initials: J
authors.lastname: Diedrichsen
authors.forename: Joshua H
authors.initials: JH
authors.lastname: Balsters
authors.forename: Jonathan
authors.initials: J
authors.lastname: Flavell
authors.forename: Emma
authors.initials: E
authors.lastname: Cussans
authors.forename: Narender
authors.initials: N
authors.lastname: Ramnani
mesh_terms: D000293:Adolescent; D000465:Algorithms; D002531:Cerebellum / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008488:Medical Illustration; D055815:Young Adult