Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population.
BACKGROUND
Chemerin is a novel adipokine previously associated with metabolic syndrome phenotypes in a small sample of subjects from Mauritius.


OBJECTIVE
The aim of the study was to determine whether plasma chemerin levels were associated with metabolic syndrome phenotypes in a larger sample from a second, unrelated human population.


METHODS
Plasma samples were obtained from the San Antonio Family Heart Study (SAFHS), a large family-based genetic epidemiological study including 1431 Mexican-American individuals. Individuals were randomly sampled without regard to phenotype or disease status. This sample is well-characterized for a variety of phenotypes related to the metabolic syndrome.


RESULTS
Plasma chemerin levels were measured by sandwich ELISA. Linear regression and correlation analyses were used to determine associations between plasma chemerin levels and metabolic syndrome phenotypes.


RESULTS
Circulating chemerin levels were significantly higher in nondiabetic subjects with body mass index (BMI) greater than 30 kg/m(2) compared with those with a BMI below 25 kg/m(2) (P < 0.0001). Plasma chemerin levels were significantly associated with metabolic syndrome-related parameters, including BMI (P < 0.0001), fasting serum insulin (P < 0.0001), triglycerides (P < 0.0001), and high-density lipoprotein cholesterol (P = 0.00014), independent of age and sex in nondiabetic subjects.


CONCLUSIONS
Circulating chemerin levels were associated with metabolic syndrome phenotypes in a second, unrelated human population. This replicated result using a large human sample suggests that chemerin may be involved in the development of the metabolic syndrome.
Bozaoglu
Kiymet
K
Metabolic Research Unit, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3218, Australia.
Segal
David
D
Shields
Katherine A
KA
Cummings
Nik
N
Curran
Joanne E
JE
Comuzzie
Anthony G
AG
Mahaney
Michael C
MC
Rainwater
David L
DL
VandeBerg
John L
JL
MacCluer
Jean W
JW
Collier
Greg
G
Blangero
John
J
Walder
Ken
K
Jowett
Jeremy B M
JB
D000328:Adult; D000368:Aged; D018925:Chemokines / Q000097:blood* / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000208:ethnology*; D017058:Mexican Americans; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D050177:Overweight / Q000097:blood; D010641:Phenotype
D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human