title: PGP 9.5 and cyclin D1 coexpression in cutaneous squamous cell carcinomas.
abstract: BACKGROUND
  squamous cell carcinoma (SCC) consists of altered keratinocytes, presents variable differentiation, inexorably progresses, and on occasion metastasizes.
  
  
  OBJECTIVE
  to investigate the biological activity of epidermal cells in SCCs by estimating the expression of PGP 9.5 and cyclin D1 using immunohistochemistry.
  
  
  METHODS
  the sample included 13 well-differentiated cases of cutaneous SCC (grade I), 12 moderately differentiated tumors (grade II), and 7 poorly differentiated lesions (grade III). Four cases belonged to the distinct entity of pseudoadenoid SCC.
  
  
  RESULTS
  PGP 9.5 expression was positively correlated with tumor stage (P < .001) and potential perineural invasion ( P < .001), whereas cyclin D1 expression correlated inversely with the degree of cellular differentiation (P < .001) and PGP 9.5 immunostaining (P < .001).
  
  
  CONCLUSIONS
  PGP 9.5 and cyclin D1 coexpression was closely associated with tumor aggressiveness and can be classified as a marker for predicting the outcome of resection-treated skin cancer patients.
authors.affiliation: 4th Department of Surgery, Athens University Medical School, Attikon University Hospital, Athens, Greece. dr_kamast@yahoo.gt
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Mastoraki
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Ioannidis
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Apostolaki
authors.forename: Efstratios
authors.initials: E
authors.lastname: Patsouris
authors.forename: Kiriaki
authors.initials: K
authors.lastname: Aroni
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D019938:Cyclin D1 / Q000378:metabolism*; D004817:Epidermis / Q000378:metabolism* / Q000473:pathology; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007124:Immunoenzyme Techniques; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D010525:Peripheral Nerves / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D043222:Ubiquitin Thiolesterase / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C530104:CCND1 protein, human; C482860:UCHL1 protein, human; D019938:Cyclin D1; D043222:Ubiquitin Thiolesterase