title: Perspective on Roseroot (Rhodiola rosea) studies.
abstract: Rhodiola rosea (roseroot) extract is a commercially successful product, primarily used to reduce the effect of fatigue on physical and mental performance. In this perspective we present our investigation of the most recent studies performed on human subjects. With a focus on the statistical methods we found considerable shortcomings in all but one of the studies that claim significant improvement from roseroot extract. Overall, the study designs have not been well explained. Experimental results have been confused and appear to be in some cases incorrect. Some of the conclusions are based on selected results and contradicting data have not been adequately taken into account. We point to other studies of higher quality performed on roseroot, several that found no significant effect and one that did. We conclude that the currently available evidence for the claimed effects is insufficient and that the effect of Rhodiola rosea is in need of further investigation before therapeutic claims can be made.
authors.affiliation: Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden.
authors.forename: Josefin
authors.initials: J
authors.lastname: Blomkvist
authors.forename: Adam
authors.initials: A
authors.lastname: Taube
authors.forename: Dan
authors.initials: D
authors.lastname: Larhammar
mesh_terms: D002986:Clinical Trials as Topic; D005221:Fatigue / Q000188:drug therapy; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D015203:Reproducibility of Results; D012107:Research Design; D029771:Rhodiola / Q000737:chemistry*
chemical_list: D010936:Plant Extracts