Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag?
BACKGROUND
Skin tags are common benign lesion occurring mainly on the neck and major flexures as a small soft pedunculated protrusion. This study evaluate insulin and insulin-like growth factor-I (IGF-I) in non-diabetic ones.


METHODS
A case-control study was conducted in non-diabetic persons. Comparing insulin and IGF-I between matched cases (n = 40) and controls (n = 40) by radioimmunoassay test. Cases and controls were recruited from patients consecutively seen at an academic outpatient dermatology clinic.


RESULTS
The insulin level in patients with skin tags was significantly higher than controls (P = 0.00) but IGF-I level was not significantly different (P = 0.43).


CONCLUSIONS
These results show an increased insulin level in non-diabetics ones and overall importance of insulin effect in pathogenesis of skin tags.
Jowkar
F
F
Dermatology Department, Shiraz University of Medical Science, Shiraz, Iran. jowkarf@yahoo.com
Fallahi
A
A
Namazi
M R
MR
D000052:Acanthosis Nigricans / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D007328:Insulin; D007334:Insulin-Like Growth Factor I