title: [The influence of sequential hormonal therapy on biochemical and cardiovascular indices in menopause].
abstract: This study follows 94 patients, age 45 to 60, by controlled, random and prospective studies in time period of six months. Out of total number of patients, 53 were divided into research group and treated with hormonal therapy (2 mg of estradiol and 0,5 mg of norgestrel), 41 patients were divided into control group and treated with refemin (Cimicifuga recemosa). Results were statistically processed using Student test and ANOVA, giving us following results: use of HNL resulted with statistically significant changes--increase of heart frequency (*p<0,01), QTc-intervals (**p=0,01), increase of systolic pressure (**p=0,01), increase of diastolic pressure (**p=0,01), increase of body mass index (**p=0,01), endometrial thickness decrease (**p=0,01); use of Cimicifuge recemose resulted with statistically significant changes--increase of diastolic pressure(*p=0,01), increase of body mass index (BMI) (*p=0,01) and endometrial thickness decrease (*p=0,05). By testing research and controlled group with ANOVA test, we have determined that there is statistical difference in operating between recovered hormone therapy and Cimicifuge recemose within parameters of hearth frequency and diastolic pressure.
authors.affiliation: Dispanzer za zdravstvenu zastitu zena sa porodilistem, Dom zdravlja Velika Kladusa.
authors.forename: Semso
authors.initials: S
authors.lastname: Rosić
authors.forename: Sulejman
authors.initials: S
authors.lastname: Kendić
authors.forename: Alma
authors.initials: A
authors.lastname: Bećirević
mesh_terms: D000328:Adult; D031885:Cimicifuga; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage*; D003279:Contraceptives, Oral, Sequential / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy; D019304:Ethinyl Estradiol-Norgestrel Combination / Q000008:administration & dosage*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008055:Lipids / Q000097:blood*; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use
chemical_list: D003278:Contraceptives, Oral, Hormonal; D003279:Contraceptives, Oral, Sequential; D008055:Lipids; D028321:Plant Preparations; D019304:Ethinyl Estradiol-Norgestrel Combination