Nutlin kills cancer cells via  mitochondrial p53.
Morselli
Eugenia
E
INSERM, U848, Institut Gustave Roussy, and Université Paris-Sud XI, Villejuif, France.
Galluzzi
Lorenzo
L
Kepp
Oliver
O
Kroemer
Guido
G
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D045744:Cell Line, Tumor; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008928:Mitochondria / Q000378:metabolism*; D010879:Piperazines / Q000494:pharmacology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D054875:Ubiquitination
D000970:Antineoplastic Agents; D007093:Imidazoles; D010879:Piperazines; D016159:Tumor Suppressor Protein p53; C482203:nutlin 1; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2