[Study on prognostic factors of chronic severe hepatitis].
OBJECTIVE
To analyze factors influencing prognosis and to develop a prognosis predicting model for patients with chronic severe hepatitis.


METHODS
Clinical data from 408 patients suffering from chronic severe hepatitis were divided into improved group and deteriorated group. The main clinical and laboratory variables were analyzed as predictive factors of prognosis with logistic regression analysis.


RESULTS
It was shown that age, sex, TBil, DBil, [Cl-], [Na+], WBC, MCV, PT, NH3, PTA, and BUN were different between the two groups with statistical significance (P < 0.05). The prognosis predicting model was P = 1/(1 + e(-y)), Y = -4.636 + 0.022X1 + 0.034X2 + 0.096X3 + 0.047X4 - 0.042X5, (X1-age, X2-TBil, X3-BUN, X4-MCV, X5-PTA).


CONCLUSIONS
Age, TBil, BUN, MCV and PTA are the independent risk factors related to prognosis of chronic severe hepatitis.
Meng
Qing-hu
QH
Department of Hepatology, Beijing You An Hospital, Capital Medical University, Beijing 100069, China.
Duan
Zhong-hui
ZH
Li
Juan
J
Yu
Hong-wei
HW
Zhang
Jian
J
Zhang
Ya
Y
Hou
Wei
W
Liu
Ya
Y
D000328:Adult; D005260:Female; D006521:Hepatitis, Chronic / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors