title: The inhibitory effect of some amphoteric surfactants on the irritation potential of alkylsulphates.
abstract: Synopsis The physico-chemical and biological properties of an amphoteric/anionic system and its behaviour against a proteinic support have been thoroughly investigated. A considerable inhibition of adsorption of SLS (sodium lauryl sulphate) on human callus caused by the presence of definite amounts of AABet (alkyl-amido-betaines) in the treatment bath is observed. These physico-chemical results are in agreement with those obtained by some in vivo biological tests. A mechanism of the process via the formation of mixed micelles is postulated emphasizing the stability of such systems as a function of pH, the influence of the chain length of the amphoteric surfactant and the molar relative ratio SLS/AABet. Consequently, our work offers the possibility of a wide applicability of the synergic mixtures of both types of surfactants to inhibit considerably skin irritation of cosmetic finished products.
authors.affiliation: Instituto de Tecnología Química y Textil (C.S.I.C.), Barcelona, Spain.
authors.forename: J G
authors.initials: JG
authors.lastname: Domínguez
authors.forename: F
authors.initials: F
authors.lastname: Balaguer
authors.forename: J L
authors.initials: JL
authors.lastname: Parra
authors.forename: C M
authors.initials: CM
authors.lastname: Pelejero