title: Association of two CETP polymorphisms with HDL levels in the Chinese obese population.
abstract: The association of two cholesterol ester transfer protein (CETP) polymorphisms, D442G and TAQIB (B1-->B2), with high-density lipoprotein (HDL) levels in 932 Chinese obese individuals (BMI >or= 27) was investigated in comparison with normal controls (BMI <or= 24). Independent association was demonstrated for TAQIB minor allele B2 and CETP442 minor allele G with elevated HDL levels. The CETP D442G polymorphism was associated with a much greater increase in HDL levels in subjects with BMI exceeding 27 kg/m(2) (+5.42 mg/dl, P = 0.0007) compared to normal controls (+1.97 mg/dl, P = 0.275), and the increase in HDL reached the highest level among subjects with BMI exceeding 30 kg/m(2) (+6.80 mg/dl, P = 0.016). TAQIB showed significant association with HDL levels only in normal BMI subgroup (P = 0.0017). TAQIB significantly interacted with serum triglyceride (TG) on modulating HDL levels (P = 0.027). The TAQIB-TG interaction effect remained marginally significant after controlling for BMI (P = 0.057). We conclude that D442G polymorphism is associated with more HDL elevation in obesity. TAQIB interacts with serum TG on modulating HDL levels, and the interaction is partly independent of BMI.
authors.affiliation: Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Ruan
authors.forename: Lina
authors.initials: L
authors.lastname: Ma
authors.forename: Shuyu
authors.initials: S
authors.lastname: Wang
authors.forename: Klaus
authors.initials: K
authors.lastname: Lindpaintner
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Liu
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Zuoqi
authors.initials: Z
authors.lastname: Peng
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
authors.forename: Maosheng
authors.initials: M
authors.lastname: Cheng
authors.forename: Jinghai
authors.initials: J
authors.lastname: Zhang
authors.forename: Lisheng
authors.initials: L
authors.lastname: Liu
authors.forename: Xingyu
authors.initials: X
authors.lastname: Wang
mesh_terms: D000483:Alleles; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics*; D006801:Humans; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D012016:Reference Values; D014280:Triglycerides / Q000097:blood / Q000235:genetics
chemical_list: D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D014280:Triglycerides