title: Space-time event sparse penalization for magneto-/electroencephalography.
abstract: This article presents a new spatio-temporal method for M/EEG source reconstruction based on the assumption that only a small number of events, localized in space and/or time, are responsible for the measured signal. Each space-time event is represented using a basis function expansion which reflects the most relevant (or measurable) features of the signal. This model of neural activity leads naturally to a Bayesian likelihood function which balances the model fit to the data with the complexity of the model, where the complexity is related to the number of included events. A novel Expectation-Maximization algorithm which maximizes the likelihood function is presented. The new method is shown to be effective on several MEG simulations of neurological activity as well as data from a self-paced finger tapping experiment.
authors.affiliation: Department of Electrical and Computer Engineering, University of Wisconsin, Madison, WI 53715, USA. akbolstad@wisc.edu
authors.forename: Andrew
authors.initials: A
authors.lastname: Bolstad
authors.forename: Barry
authors.initials: B
authors.lastname: Van Veen
authors.forename: Robert
authors.initials: R
authors.lastname: Nowak
mesh_terms: D000465:Algorithms; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D015225:Magnetoencephalography; D008959:Models, Neurological