[Immunity and lymphocytic-thrombocytic adhesion in community-aquired pneumonia].
OBJECTIVE
To investigate immunity and lymphocytic-thrombocytic adhesion in pneumonia patients.


METHODS
The examination of 59 male patients with pneumonia aged 18-21 years included calculation of total leucocyte count, lymphocyte subpopulations, relative and absolute count of lymphocytic-thrombocytic aggregates (LTA), measurement of IgA, IgM, IgG concentrations.


RESULTS
Pneumonia patients have high count of leukocytes and low count of total and relative count of lymphocytes, low number of main lymphocytic subpopulations (CD4+, CD8+, CD16+, CD22+). Patients with uncomplicated pneumonia demonstrated high ability of lymphocytes for forming coaggregates with platelets. Patients with severe pneumonia complications may have either very high count of LTA (mean 403 +/- 45.6) or very low (mean 42.6 +/- 8.1). Percent of lymphocytes able to adhere to platelets (CD4+ with CD16+) in pneumonia is low. No correlation was found between LTA and the level of IgA, IgG, IgG.


CONCLUSIONS
LTA is an objective indicator of cellular immunity status in pneumonia patients.
Vitkovski
Iu A
IuA
Golodnykh
Iu V
IuV
Kuznik
B I
BI
Likhanov
I D
ID
Solpov
A V
AV
D000293:Adolescent; D001772:Blood Cell Count; D002448:Cell Adhesion / Q000276:immunology; D006801:Humans; D007109:Immunity; D007136:Immunoglobulins / Q000097:blood; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D010973:Platelet Adhesiveness / Q000276:immunology*; D011014:Pneumonia / Q000175:diagnosis / Q000276:immunology*; D055815:Young Adult
D007136:Immunoglobulins