title: Diagnostic management of clinically suspected acute deep vein thrombosis.
abstract: Deep vein thrombosis (DVT) is a common disease that may lead to potentially fatal complications, such as pulmonary embolism. In the past decades several diagnostic tools and algorithms for DVT have been studied. Currently the combination of a clinical decision rule, D-dimer testing and compression ultrasonography has proved to be safe and effective for the diagnosis of DVT in the lower extremities. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) can be useful as additional or secondary imaging modalities. This review will discuss the elements currently used in making the clinical diagnosis of DVT. These elements include clinical decision rules and D-dimer testing, different imaging investigations and the appropriate use of these within diagnostic algorithms in patients with clinically suspected DVT. Although current knowledge of the options available to diagnose DVT of the lower extremities is well established, there are still unresolved issues, including the optimal diagnosis of recurrent DVT and distal DVT. Furthermore, the diagnosis of DVT of the upper extremities will be discussed, including the different imaging modalities and the limitations of these techniques.
authors.affiliation: Section of Vascular Medicine, Department of General Internal Medicine - Endocrinology, Leiden University Medical Centre (LUMC), 2300 RC Leiden, The Netherlands.
authors.forename: Melanie
authors.initials: M
authors.lastname: Tan
authors.forename: Cornelis J
authors.initials: CJ
authors.lastname: van Rooden
authors.forename: Robin E
authors.initials: RE
authors.lastname: Westerbeek
authors.forename: Menno V
authors.initials: MV
authors.lastname: Huisman
mesh_terms: D000465:Algorithms; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D018570:Risk Assessment / Q000379:methods; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000000981:diagnostic imaging
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D