Atypical neurofibroma of the skin and subcutaneous tissue: clinicopathologic analysis of 11 cases.
BACKGROUND
Neurofibroma (NF) is a relatively common cutaneous tumor, which typically presents little diagnostic difficulty. Occasionally, however, pleomorphic cells may be present in NF raising consideration of other neoplasms like malignant peripheral nerve sheath tumor (MPNST).


METHODS
This study examines the clinicopathologic and immunohistochemical features of 11 dermal and subcutaneous 'atypical' NF.


RESULTS
9/11 (82%) atypical NF were from females, aged 8-70 years. One patient had neurofibromatosis-1. Most presented on the extremities or trunk. The atypical cells had large hyperchromatic, irregular nuclei, and were arranged in a distinct lamellar or fibrillar pattern. Some tumors were hypercellular, but marked density characteristic of MPNST was not observed. All were nonplexiform. Mitoses were mostly absent. The pleomorphic cells expressed S-100 protein. All were negative for p53. MIB-1 was negative in 7/10 (70%) and stained only rare cells in 3 (30%). Epithelial membrane antigen (EMA) and p16 expression were variable. Of six patients with available follow-up, no tumor recurred and none developed malignancy (range 6-63, mean 33 months).


CONCLUSIONS
Superficial atypical NF, while morphologically unusual, has no apparent association with neurofibromatosis-1 or short-term risk of recurrence or malignant transformation. Awareness of this variant is important in order to avoid misdiagnosis of a more aggressive neoplasm.
Jokinen
Chris H
CH
Department of Pathology, Division of Dermatology, University of Washington, Seattle, WA 98195, USA.
Argenyi
Zsolt B
ZB
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018317:Nerve Sheath Neoplasms / Q000473:pathology; D009455:Neurofibroma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D040521:Subcutaneous Tissue / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D055815:Young Adult
D014408:Biomarkers, Tumor; D009418:S100 Proteins