title: Influence of antigen exposure on the loss of long-term memory to childhood vaccines in HIV-infected patients.
abstract: The role of antigen exposure and of CD4 cell deficiency in the long-term persistence of immune memory to childhood vaccines remains uncertain, particularly during HIV infection. We analyzed in vaccinated ART-treated HIV+ patients with undetectable plasma HIV and CD4 cells >250/mm(3) the persistence of two memory cell pools: effector IFNgamma-producing and proliferative central memory T cells against two vaccines: (i) vaccinia against the eradicated smallpox virus, and (ii) BCG against Mtb, a persistent pathogen. None of the HIV+ patients had IFNgamma-effector cells against VV while the one patient with BCG-specific effector T cells had a recent history of tuberculosis. Proliferative responses were detectable but showed significantly lower frequency and intensity of VV-specific than tuberculin-specific responses, independently of the CD4 nadir. Thus, differential patterns of persistence or recovery of T cell memory pools against childhood vaccines are observed in treated HIV infection that are governed by antigen exposure.
authors.affiliation: Inserm, UMRS-945 Laboratoire d'Immunologie Cellulaire et Tissulaire, Paris F-75013, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Puissant-Lubrano
authors.forename: Béhazine
authors.initials: B
authors.lastname: Combadière
authors.forename: Darragh
authors.initials: D
authors.lastname: Duffy
authors.forename: Norma
authors.initials: N
authors.lastname: Wincker
authors.forename: Marie-Joelle
authors.initials: MJ
authors.lastname: Frachette
authors.forename: Hocine
authors.initials: H
authors.lastname: Ait-Mohand
authors.forename: Bernard
authors.initials: B
authors.lastname: Verrier
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Brigitte
authors.initials: B
authors.lastname: Autran
mesh_terms: D000328:Adult; D001500:BCG Vaccine / Q000276:immunology*; D005260:Female; D015488:HIV Antigens / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination; D014615:Vaccinia / Q000276:immunology*
chemical_list: D001500:BCG Vaccine; D015488:HIV Antigens; D007371:Interferon-gamma