Activity and mechanism of sebathionine (D.C.I.) on sebum formation.
Synopsis An experimental study of seborrheic sebathionine activity has been carried out on the flank organ of castrated and testosterone-treated hamsters. Lipid synthesis is followed by the incorporation of labelled precursors. Sebathionine decreases the incorporation of both glucose and sodium acetate to the same extent in the lipids of the sebaceous gland. The non-specific nature of this inhibition has been shown by the decrease in the rate of incorporation of a similar non-precursor molecule deoxyglucose. The effect of the sebathionine appears to be an inhibition of the lengthening of the fatty chains rather than the inhibition of unsaturation of the fats.
Oustrin
J
J
Laboratoire de Biophysique et Biomathématiques, Faculté des Sciences Pharmaceutiques, Université Paul Sabatier, 35, chemin des MaraIchers, 31062 Toulouse Cedex, France.
Romecki
A
A