title: Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis.
abstract: Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder which includes both clinical and neuropathological features of a frontotemporal lobar degeneration (FTLD). In order to provide a common framework within which to discuss the characteristics of the cognitive and behavioural syndromes of ALS, and with which to conduct clinical and neuropathological research, an international research workshop on frontotemporal dementia (FTD) and ALS was held in London, Canada in June 2007. The recommendations arising from this research workshop address the requirement for a concise clinical diagnosis of the underlying motor neuron disease (Axis I), defining the cognitive and behavioural dysfunction (Axis II), describing additional non-motor manifestations (Axis III) and identifying the presence of disease modifiers (Axis IV).
authors.affiliation: Department of Clinical Neurological Sciences, The University of Western Ontario, London, Ontario, Canada. mstrong@uwo.ca
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Strong
authors.forename: Gloria M
authors.initials: GM
authors.lastname: Grace
authors.forename: Morris
authors.initials: M
authors.lastname: Freedman
authors.forename: Cathy
authors.initials: C
authors.lastname: Lomen-Hoerth
authors.forename: Susan
authors.initials: S
authors.lastname: Woolley
authors.forename: Laura H
authors.initials: LH
authors.lastname: Goldstein
authors.forename: Jennifer
authors.initials: J
authors.lastname: Murphy
authors.forename: Christen
authors.initials: C
authors.lastname: Shoesmith
authors.forename: Jeffery
authors.initials: J
authors.lastname: Rosenfeld
authors.forename: P Nigel
authors.initials: PN
authors.lastname: Leigh
authors.forename: Lucie
authors.initials: L
authors.lastname: Bruijn
authors.forename: Paul
authors.initials: P
authors.lastname: Ince
authors.forename: Denise
authors.initials: D
authors.lastname: Figlewicz
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D032921:Consensus; D003704:Dementia / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology / Q000473:pathology