[Modern leukemia diagnosis in adults].
Identification of numerous criteria important in the pathogenesis, biology, prognosis and treatment of the different types of leukemia necessitates a broad spectrum of diagnostic methods for the initial diagnosis and in the further course of the disease. In addition to cytomorphology with cytochemistry, which is been path-breaking for the application of further diagnostic methods, cytogenetics has become an obligatory diagnostic tool. Immunophenotyping and, even more relevant, molecular genetics plays an important role. Other diagnostic techniques are widely developed. The diagnostic procedures are described, with a focus on their mode of operation as well as their clinical significance. Because of their high clinical relevance and growing complexity, the diagnosis of leukemias should be performed in specialized laboratories.
Heilmeier
B
B
Labor für Leukämiediagnostik, Medizinische Klinik und Poliklinik III, Klinikum der Universität München, Campus Grosshadern, Marchioninistrasse 15, Munich.
Spiekermann
K
K
Bohlander
S
S
Buske
C
C
Feuring-Buske
M
M
Schneider
S
S
Hiddemann
W
W
Braess
J
J
D000328:Adult; D020732:Cytogenetic Analysis; D003584:Cytological Techniques; D006651:Histocytochemistry; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007938:Leukemia / Q000175:diagnosis*; D018365:Neoplasm, Residual / Q000175:diagnosis; D020411:Oligonucleotide Array Sequence Analysis; D016133:Polymerase Chain Reaction; D011379:Prognosis