Synthesis of amino acid derivatives of quinolone antibiotics.
Optically pure conjugates of quinolone antibiotics with naturally occurring amino acids are synthesized in 40-98% yields.
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Munawar
Munawar Ali
MA
Kovacs
Judit
J
Khelashvili
Levan
L
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002937:Cinoxacin / Q000138:chemical synthesis / Q000737:chemistry; D024841:Fluoroquinolones / Q000138:chemical synthesis / Q000737:chemistry; D009268:Nalidixic Acid / Q000138:chemical synthesis / Q000737:chemistry; D010093:Oxolinic Acid / Q000138:chemical synthesis / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D011804:Quinolines; D014230:Triazoles; D009268:Nalidixic Acid; C012771:benzotriazole; D010093:Oxolinic Acid; D002937:Cinoxacin; C012976:flumequine