Research on the bioactivities of C60-dexamethasone.
The bioactivities, including the anti-inflammatory activity and influences on the learning function and the immunosuppression activity, of C60-dexamethasone have been studied in mice and compared with those of dexamethasone. C60-dexamethasone and dexamethasone were administered orally at dosage of 30 micromol/kg x d. The experiments showed that C60-dexamethasone retained the anti-inflammatory activity. On the other side the influences of C60-dexamethasone on the learning function and the immunosuppression activity were much lower than that of dexamethasone. The scavenging test for lipophilic DPPH free radical indicated that C60-dexamethasone was an efficient free radical remover or antioxidant, which was responsible for the reduction of side effects of C60-dexamethasone.
Liu
Ruili
R
Laboratory of Nano-Biology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Science, Shanghai 201800, China.
Cai
Xiaoqing
X
Wang
Jiandong
J
Li
Jungang
J
Huang
Qing
Q
Li
Wenxin
W
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D003907:Dexamethasone / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D037741:Fullerenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D010851:Picrates / Q000378:metabolism; D013154:Spleen / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D001713:Biphenyl Compounds; D037741:Fullerenes; D007166:Immunosuppressive Agents; D010851:Picrates; D003907:Dexamethasone; C004931:1,1-diphenyl-2-picrylhydrazyl; C069837:fullerene C60