[Influence of leptin and adiponectin on prostate cancer].
BACKGROUND
Many studies have investigated the association between obesity, adipose tissue-derived factors (leptin and adiponectin) and prostate cancer (CaP) but the results are still inconsistent.


METHODS
The aim of this study was to carry out a comprehensive review of the existing evidence about the role of leptin and adiponectin in prostate carcinogenesis and to provide an overview of it.


RESULTS
Recent evidence suggests that leptin may play a rol in prostate cancer progression, while adiponectin may act as an "antiprostatic cancer" adipokine.


CONCLUSIONS
Obesity may promote the progression of established prostate cancer and and adipokines may provide a molecular mechanism whereby obesity exerts its effects on prostate tumour biology.
Lopez Fontana
Constanza M
CM
Metabolic and Cancer Laboratory, Faculty of Pharmacy and Biochemistry, University Juan Agustin Maza, Argentina.
Maselli Artola
Maria E
ME
Di Milta Monaco
Nicolas
N
Recalde Rincon
Gabriela M
GM
Vanrell Rodriguez
Maria C
MC
Uvilla Recupero
Ana
A
Messina Lombino
Diego
D
Perez Elizalde
Rafael F
RF
Lopez Laur
Jose Daniel
JD
D052242:Adiponectin / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000502:physiology*; D008297:Male; D011471:Prostatic Neoplasms / Q000209:etiology*
D052242:Adiponectin; D020738:Leptin