title: Multiperturbation analysis of distributed neural networks: the case of spatial neglect.
abstract: This study assesses the feasibility of using a multiperturbation analysis (MPA) approach for lesion-symptom mapping. We analyze the relative contribution of damage in different brain regions to the expression of spatial neglect, as revealed in line-bisection performance. The data set comprised of normalized lesion information and bisection test results from 23 first-event right-hemisphere stroke patients. Obtaining quantitative measures of task relevance for different regions of interest (ROIs), the following ROIs were found to be the most contributing: the supramarginal and angular gyri of the inferior parietal lobule, the superior parietal lobule, the anterior part of the temporo-parietal junction connecting the superior temporal and supramarginal gyri, and the thalamus. MPA is likely to play an important role in elucidating the anatomical substrate of complex functions.
authors.affiliation: Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem, Israel. kalon@post.tau.ac.il
authors.forename: Alon
authors.initials: A
authors.lastname: Kaufman
authors.forename: Corinne
authors.initials: C
authors.lastname: Serfaty
authors.forename: Leon Y
authors.initials: LY
authors.lastname: Deouell
authors.forename: Eytan
authors.initials: E
authors.lastname: Ruppin
authors.forename: Nachum
authors.initials: N
authors.lastname: Soroker
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology; D016571:Neural Networks, Computer; D009434:Neural Pathways / Q000473:pathology; D010468:Perceptual Disorders / Q000473:pathology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011597:Psychomotor Performance / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D015898:Tomography Scanners, X-Ray Computed