Complex interactions in the regulation of trypanosome mitochondrial gene expression.
Trypanosomes undergo extreme physiological changes to adapt to different environments as they cycle between hosts. Adaptation to the different environments has evolved an energy metabolism involving a mitochondrion with an unusual genome. Recently, Aphasizhev and colleagues have identified two new protein complexes, a mitochondrial polyadenylation complex and a guide RNA stabilization complex, that provide novel insights into the coordinated expression of the mitochondrial genome.
Koslowsky
Donna J
DJ
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
D000818:Animals; D018105:DNA, Kinetoplast / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D050259:Genes, Mitochondrial; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism*; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000378:metabolism*
D018105:DNA, Kinetoplast; D015800:Protozoan Proteins