title: Progression from an immature teratoma with miliary gliomatosis peritonei to growing teratoma syndrome with nodular gliomatosis peritonei.
abstract: A 4 1/2-year-old girl presented with an incompletely resected, huge, immature abdominal teratoma, elevated serum alpha-fetoprotein (AFP), and numerous miuiary gliomatosis peritonei (GP). Two courses of chemotherapy resulted in normalization of her AFP level and marked tumor shrinkage. Further chemotherapy was interrupted by complications. During treatment for these complications, ascites increased and the tumor enlarged, but serum AFP remained within the normal range. Second-took surgery revealed that the tumor had changed histologically to a mature teratoma, and GP had enlarged to nodular size, causing massive ascites. The still incompletely resected, growing mature teratoma was reduced with interferon. Nodular GP and ascites slowly regressed with interferon use, and finally disappeared after several months. One residual mass thought to be GP was reduced by gamma-knife surgery 3 years later.
authors.affiliation: Department of Pediatrics, Cathay General Hospital, Taiwan, ROC. hsiehyuhlin@yahoo.com.tw
authors.forename: Yuh-Lin
authors.initials: YL
authors.lastname: Hsieh
authors.forename: Chin-Su
authors.initials: CS
authors.lastname: Liu
mesh_terms: D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D010534:Peritoneal Neoplasms / Q000473:pathology* / Q000628:therapy; D013577:Syndrome; D013724:Teratoma / Q000473:pathology* / Q000628:therapy