title: Symptom classification in irritable bowel syndrome as a guide to treatment.
abstract: OBJECTIVE
  The treatment of irritable bowel syndrome (IBS) remains unsatisfactory. There are no objective markers for diagnosis, and classification (currently based on symptoms) provides little insight into potential causes or optimal therapy. The aim of this study was to determine whether a Swedish classification of IBS based on cluster analysis of patients' symptoms might provide a guide to successful treatment.
  
  
  METHODS
  Patients in a research clinic for IBS were classified according to criteria published by Ragnarsson & Bodemar (R&B) and also assessed independently by a clinician. Patients fulfilling the R&B criteria for subgroups 1 and 2 received specific treatments, either bulk laxatives or dietary treatment to reduce colonic fermentation, respectively. Patients who did not fit into these categories were given "best treatment" targeted at their predominant symptoms, but not limited in any way. Results before and after follow-up were assessed using a validated symptom-scoring scale.
  
  
  RESULTS
  Seventy-one successive patients were recruited, and the numbers falling into R&B subgroups 1 and 2 were 15 (21%), and 28 (39%), respectively, leaving 28 (39%) unclassified. Receiver operating characteristic plots showed that the criteria for separation into subgroups 1 and 2 correlated well with the clinician's assessment. After treatment, symptom scores for the whole group showed a significant improvement (p<0.0001), but results were significantly better in subgroups 1 and 2 than in those unclassified, even when allowance was made for a potential therapeutic placebo effect of 40%.
  
  
  CONCLUSIONS
  The R&B classification provides a helpful guide to treatment in many cases of IBS.
authors.affiliation: Gastroenterology Research Unit, Addenbrooke's Hospital, Hills Road, Cambridge, UK.
authors.forename: Maureen
authors.initials: M
authors.lastname: Wiesner
authors.forename: Sally J
authors.initials: SJ
authors.lastname: Naylor
authors.forename: Ann
authors.initials: A
authors.lastname: Copping
authors.forename: Anita
authors.initials: A
authors.lastname: Furlong
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Lynch
authors.forename: Miles
authors.initials: M
authors.lastname: Parkes
authors.forename: John O
authors.initials: JO
authors.lastname: Hunter
mesh_terms: D000328:Adult; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000145:classification* / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D016896:Treatment Outcome