Designing switchable enzymes.
The modulation of enzyme function is a key regulatory feature of biological systems. The ability to engineer synthetic enzymes that can be controlled by any arbitrary signal would enable a wide array of sensing applications and therapeutics and provide us with powerful tools for the basic study of biology. Here several recent advances in the engineering of switchable enzymes through domain fusion are discussed.
Ostermeier
Marc
M
Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA. oster@jhu.edu
D000494:Allosteric Regulation; D000818:Animals; D003198:Computer Simulation; D004798:Enzymes / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D008954:Models, Biological; D011485:Protein Binding; D015202:Protein Engineering / Q000379:methods*
D004798:Enzymes