title: A new seco-friedelolactone acid from the bark and twigs of Itoa orientalis.
abstract: A new seco-friedelolactone, named itoaic acid, together with 5 known compounds was isolated from the bark and twigs of Itoa orientalis. The structure was elucidated by means of MS, 1D and 2D NMR techniques. Anti-inflammatory activity against COX-2 was evaluated for several compounds from I. orientalis and another Flacourtiaceae plant Xylosma controversum.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
authors.forename: Xing-Yun
authors.initials: XY
authors.lastname: Chai
authors.forename: Zheng-Ren
authors.initials: ZR
authors.lastname: Xu
authors.forename: Chang-Cai
authors.initials: CC
authors.lastname: Bai
authors.forename: Fei-Ran
authors.initials: FR
authors.lastname: Zhou
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Tu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051546:Cyclooxygenase 2 / Q000378:metabolism; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018547:Plant Stems; D031308:Salicaceae / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; C544790:itoaic acid; D009828:Oleanolic Acid; D051546:Cyclooxygenase 2