title: [Ivabradine - a new therapeutic option for cardiogenic shock?].
abstract: Documented mortality from acute myocardial infarction (AMI) has significantly decreased from around 30% in the 1960s to currently 6-7%, following the introduction of intensive-care treatment, thrombolysis, effective antithrombotic therapy, and coronary angioplasty. However, the approximate mortality of 70-80% of patients with cardiogenic shock following AMI has hardly improved despite the introduction of modern treatment strategies. The major cause of in-hospital AMI mortality remains myocardial failure with consecutive cardiogenic shock and multiorgan failure. Reduction of heart rate is one of the most important energy-saving maneuvers, which can be achieved by administration of beta-receptor-blocking agents. In patients with clinical signs of hypotension, however, the guidelines recommend to stabilize the patient before administering an oral beta-receptor blocker, mainly because of the hypotensive effects of the substance class. In this situation, selective heart rate reduction, e.g., via administration of ivabradine without side effects of hypotension may be advantageous and better tolerated in patients with cardiogenic shock. The aim of the present review is to briefly summarize the treatment options of cardiogenic shock and the mechanisms of action of ivabradine as well as to present a case report of a patient with cardiogenic shock due to main trunk occlusion, where treatment with ivabradine seemed to beneficially influence the outcome.
authors.affiliation: II. Medizinische Klinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität, Langenbeckstrasse 1, 55131 Mainz. post@2-med.klinik.uni-mainz.de
authors.forename: Felix
authors.initials: F
authors.lastname: Post
authors.forename: Thomas
authors.initials: T
authors.lastname: Münzel
mesh_terms: D001552:Benzazepines / Q000008:administration & dosage*; D006801:Humans; D000077550:Ivabradine; D012770:Shock, Cardiogenic / Q000517:prevention & control*
chemical_list: D001552:Benzazepines; D000077550:Ivabradine