Aminoquinoline derivatives with antiproliferative activity against melanoma cell line.
The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC(50)=0.77 and 0.79microM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.
Nam
Bong Soo
BS
Life Sciences Research Division, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea.
Kim
Hwan
H
Oh
Chang-Hyun
CH
Lee
So Ha
SH
Cho
Seung Joo
SJ
Sim
Tae Bo
TB
Hah
Jung-Mi
JM
Kim
Dong Jin
DJ
Choi
Jung Hoon
JH
Yoo
Kyung Ho
KH
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008545:Melanoma / Q000188:drug therapy
D000634:Aminoquinolines; D000970:Antineoplastic Agents