title: To what extent does Neisseria gonorrhoeae multiantigen sequence typing of gonococcal isolates support information derived from patient interviews?
abstract: Gonococcal isolates from genitourinary (GU) medicine clinic attendees in Glasgow, Scotland were typed using Neisseria gonorrhoeae multiantigen sequence typing (NG-MAST). Correlation between named partners (contacts) and NG-MAST type was sought and associations between specific NG-MAST types, and the social, epidemiological and geographical data were explored. We found NG-MAST typing to be a supportive and confirmatory tool for contact tracing. Specific NG-MAST types were found to be associated with distinct characteristics such as sexuality or chlamydial co-infection. An increased number of gonococcal infections were reported from those resident in deprived areas of Glasgow than from those resident in more affluent areas. However, there was no clear geographic clustering of specific NG-MAST types found within the city. Routinely observing the spread of common strains of gonorrhoea is likely best done from a larger geographical perspective unless a specific outbreak occurs.
authors.affiliation: Sandyford, 2-6 Sandyford Place, Glasgow G3 7NB, UK. kirsty.abu-rajab@nhs.net
authors.forename: K
authors.initials: K
authors.lastname: Abu-Rajab
authors.forename: H M
authors.initials: HM
authors.lastname: Palmer
authors.forename: A
authors.initials: A
authors.lastname: Scoular
authors.forename: S
authors.initials: S
authors.lastname: Church
authors.forename: J
authors.initials: J
authors.lastname: Connell
authors.forename: G
authors.initials: G
authors.lastname: Hart
authors.forename: A J
authors.initials: AJ
authors.lastname: Winter
mesh_terms: D000328:Adult; D000942:Antigens, Bacterial / Q000235:genetics*; D015373:Bacterial Typing Techniques; D016358:Contact Tracing; D005260:Female; D005838:Genotype; D006069:Gonorrhea / Q000453:epidemiology* / Q000382:microbiology*; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D009344:Neisseria gonorrhoeae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D012606:Scotland / Q000453:epidemiology; D017422:Sequence Analysis, DNA; D012747:Sexual Partners; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000942:Antigens, Bacterial