Low-dose aspirin has no impact on systemic level of serine protease inhibitors in healthy volunteers.
Low-dose aspirin (100 mg/day) was recently found to increase serum levels of alpha-1 protease inhibitor (A1-PI). Here, we studied the serum levels of 2 major serine protease inhibitors, A1-PI and serine leukocyte protease inhibitor (SLPI), in 10 Helicobacter pylorinegative healthy volunteers (HVs) treated with low-dose aspirin alone and in combination with other drugs.(1) Neither the treatment with low-dose aspirin alone or in combination altered serum levels of both serine protease inhibitors. The previously described increase of A1-PI levels by low-dose aspirin was most likely caused by multiple endoscopies within a few days, which caused a systemic stress response.
Wex
Thomas
T
Treiber
Gerhard
G
Link
Alexander
A
Wex
Heike
H
Malfertheiner
Peter
P
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D053481:Secretory Leukocyte Peptidase Inhibitor / Q000097:blood; D015842:Serine Proteinase Inhibitors / Q000097:blood*; D055815:Young Adult
D000894:Anti-Inflammatory Agents, Non-Steroidal; C506814:SLPI protein, human; D053481:Secretory Leukocyte Peptidase Inhibitor; D015842:Serine Proteinase Inhibitors; D001241:Aspirin