title: Screening tests of free radical scavengers for preventing sun-accelerated cutaneous ageing.
abstract: Synopsis Free radical formation has been shown to occur in UV-irradiated skin and a large body of evidence suggests that these reactive agents are responsible for sun-accelerated cutaneous ageing. The paper describes two tests for screening free radical scavengers potentially capable of inhibiting photo-induced skin alterations. They are based on analysis of thiobarbituric acid-reactive materials either in an acellular model in vitro or in the epidermis of rose bengal-sensitized mice after white light irradiation. The tests were illustrated with silymarin, a potent vegetable free radical scavenger.
authors.affiliation: Laboratoire de Physiolgie Celluiaire, Université Montpellier 1, 15 avenue Charles Flahault, 34060 Montpellier Cedex.
authors.forename: C
authors.initials: C
authors.lastname: Bonne
authors.forename: A
authors.initials: A
authors.lastname: Muller
authors.forename: C
authors.initials: C
authors.lastname: Gregoire
authors.forename: D
authors.initials: D
authors.lastname: Sincholle