title: Identifying infection-associated genes of Candida albicans in the postgenomic era.
abstract: The human pathogenic yeast Candida albicans can cause an unusually broad range of infections reflecting a remarkable potential to adapt to various microniches within the human host. The exceptional adaptability of C. albicans is mediated by rapid alterations in gene expression in response to various environmental stimuli and this transcriptional flexibility can be monitored with tools such as microarrays. Using such technology it is possible to (1) capture a genome-wide portrait of the transcriptome that mirrors the environmental conditions, (2) identify known genes, signalling pathways and transcription factors involved in pathogenesis, (3) identify new patterns of gene expression and (4) identify previously uncharacterized genes that may be associated with infection. In this review, we describe the molecular dissection of three distinct stages of infections, covering both superficial and invasive disease, using in vitro, ex vivo and in vivo infection models and microarrays.
authors.affiliation: Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute, Beutenbergstrasse 11a, Jena, Germany.
authors.forename: Duncan
authors.initials: D
authors.lastname: Wilson
authors.forename: Sascha
authors.initials: S
authors.lastname: Thewes
authors.forename: Katherina
authors.initials: K
authors.lastname: Zakikhany
authors.forename: Chantal
authors.initials: C
authors.lastname: Fradin
authors.forename: Antje
authors.initials: A
authors.lastname: Albrecht
authors.forename: Ricardo
authors.initials: R
authors.lastname: Almeida
authors.forename: Sascha
authors.initials: S
authors.lastname: Brunke
authors.forename: Katharina
authors.initials: K
authors.lastname: Grosse
authors.forename: Ronny
authors.initials: R
authors.lastname: Martin
authors.forename: Francois
authors.initials: F
authors.lastname: Mayer
authors.forename: Ines
authors.initials: I
authors.lastname: Leonhardt
authors.forename: Lydia
authors.initials: L
authors.lastname: Schild
authors.forename: Katja
authors.initials: K
authors.lastname: Seider
authors.forename: Melanie
authors.initials: M
authors.lastname: Skibbe
authors.forename: Silvia
authors.initials: S
authors.lastname: Slesiona
authors.forename: Betty
authors.initials: B
authors.lastname: Waechtler
authors.forename: Ilse
authors.initials: I
authors.lastname: Jacobsen
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hube
mesh_terms: D002176:Candida albicans / Q000472:pathogenicity*; D002177:Candidiasis / Q000382:microbiology*; D005656:Fungal Proteins / Q000235:genetics*; D020869:Gene Expression Profiling; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D005656:Fungal Proteins; D037521:Virulence Factors