Molecular encapsulation of 5-nitroindazole derivatives in 2,6-dimethyl-beta-cyclodextrin: electrochemical and spectroscopic studies.
Four different 5-nitroindazole derivatives (1-4) and its inclusion with Heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DMbetaCD) were investigated. The stoichiometric ratios and stability constants describing the extent of formation of the complexes were determined by phase-solubility measurements obtaining in all cases a type-A(L) diagram. Also electrochemical studies were carried out, where the observed change in the E(PC) value indicated a lower feasibility of the nitro group reduction. The same behavior was observed in the ESR studies. The detailed spatial configuration is proposed based on 2D NMR methods. These results are further interpreted using molecular modeling studies. The latter results are in good agreement with the experimental data.
Pérez-Cruz
Fernanda
F
Departamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 1, Chile.
Jullian
Carolina
C
Rodriguez
Jorge
J
Arán
Vicente J
VJ
Olea-Azar
Claudio
C
D016503:Drug Delivery Systems / Q000379:methods*; D004563:Electrochemistry; D004578:Electron Spin Resonance Spectroscopy; D007191:Indazoles / Q000008:administration & dosage* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D012995:Solubility; D014344:Trypanocidal Agents / Q000008:administration & dosage* / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
D007191:Indazoles; D014344:Trypanocidal Agents; D047392:beta-Cyclodextrins; C530840:5-nitroindazole; C038119:heptakis(2,6-O-dimethyl)beta-cyclodextrin