title: Long lasting response to the multikinase inhibitor bay 43-9006 (Sorafenib) in a heavily pretreated metastatic thymic carcinoma.
abstract: Metastatic thymic carcinoma is an aggressive neoplasm for which multimodal therapies are often ineffective. We describe here a heavily pretreated patient with advanced thymic carcinoma responsive to multikinases inhibitor BAY 43-9006 (Sorafenib). Of note, a hitherto unreported c-kit missense mutation on exon 17 (D820E) identified in tumor cells seems to explain the clinical response and highlight the key role of molecular analysis in predicting efficacy of targeted therapies even in thymic neoplasms.
authors.affiliation: Operative Units of Oncology, Azienda Ospedaliera S Maria Nuova, Reggio Emilia, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Bisagni
authors.forename: Giulio
authors.initials: G
authors.lastname: Rossi
authors.forename: Alberto
authors.initials: A
authors.lastname: Cavazza
authors.forename: Giuliana
authors.initials: G
authors.lastname: Sartori
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gardini
authors.forename: Corrado
authors.initials: C
authors.lastname: Boni
mesh_terms: D001483:Base Sequence; D001557:Benzenesulfonates / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020125:Mutation, Missense / Q000235:genetics; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D011725:Pyridines / Q000627:therapeutic use*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors; D000077157:Sorafenib; D013945:Thymoma / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary
chemical_list: D001557:Benzenesulfonates; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib; D019009:Proto-Oncogene Proteins c-kit; D040262:Receptors, Vascular Endothelial Growth Factor