title: Community-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population.
abstract: OBJECTIVE
  To investigate alterations of insulin resistance (IR), chronic inflammation and urine albumin-to-creatinine ratio (ACR) in Chinese community-based prediabetic population.
  
  
  METHODS
  252 prediabetics [prediabetes (PD), including impaired fasting glucose (IFG), 91; impaired glucose tolerance (IGT), 123; IFG+IGT, 38] and 38 newly diagnosed-diabetics (NDDM) aged over 35 years older were screened from 2336 community individuals. 123 age and gender matched individuals with normal glucose tolerance (NGT) were selected as controls. Serum adiponectin, interleukin-6 (IL-6) levels and urine ACR were determined, HOMA-IR and Gutt's index were calculated to evaluate IR and insulin sensitivity, respectively.
  
  
  RESULTS
  The data displayed significant difference of serum adiponectin, IL-6, ACR and Gutt's index among PD, NDDM and NGT groups. Adiponectin level and Gutt's index decreased, but IL-6 level and ACR increased gradually among NGT, PD and NDDM groups (P<0.01). Unlike adiponectin and IL-6, ACR analysis indicates a gradual increase from NGT, IFG, IGT, IFG+IGT to NDDM individuals (P<0.01). Gutt's index showed significant difference between IFG and NDDM, IFG+IGT and NDDM (P<0.01), but HOMA-IR index did not.
  
  
  CONCLUSIONS
  IR, chronic inflammation and endothelial dysfunction dose exist in prediabetic individuals, especially in IFG+IGT population. Gutt's index and ACR might seem to be more sensitive than adiponectin and HOMA-IR index as IR and chronic inflammation maker in prediabetic population.
authors.affiliation: Department of Endocrinology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Lü
authors.forename: Nanwei
authors.initials: N
authors.lastname: Tong
authors.forename: Yupu
authors.initials: Y
authors.lastname: Liu
authors.forename: Nali
authors.initials: N
authors.lastname: Li
authors.forename: Xialian
authors.initials: X
authors.lastname: Tang
authors.forename: Jianlin
authors.initials: J
authors.lastname: Zhao
authors.forename: Hongyi
authors.initials: H
authors.lastname: Cao
authors.forename: Daigang
authors.initials: D
authors.lastname: Li
authors.forename: Lingli
authors.initials: L
authors.lastname: Gou
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Wan
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000453:epidemiology; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006801:Humans; D007249:Inflammation / Q000453:epidemiology*; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D012016:Reference Values
chemical_list: D052242:Adiponectin; D015850:Interleukin-6; D008055:Lipids; D003404:Creatinine