title: Improved copper(I)-NHC catalytic efficiency on huisgen reaction by addition of aromatic nitrogen donors.
abstract: A simple addition with a large impact: Addition of aromatic amines such as phenanthroline and 4-DMAP (4-dimethylaminopyridine) increases copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) catalytic activity of [CuCl(SIMes)] at a large range of temperatures in such a way that efficient catalysis can safely take place in hydro-alcoholic solvents (see scheme).
authors.affiliation: Clermont Université, SEESIB, UMR CNRS 6504, Université Blaise Pascal, 24 Avenue des Landais, 63177 Aubière CEDEX, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Teyssot
authors.forename: Aurélien
authors.initials: A
authors.lastname: Chevry
authors.forename: Mounir
authors.initials: M
authors.lastname: Traïkia
authors.forename: Malika
authors.initials: M
authors.lastname: El-Ghozzi
authors.forename: Daniel
authors.initials: D
authors.lastname: Avignant
authors.forename: Arnaud
authors.initials: A
authors.lastname: Gautier
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*; D012997:Solvents; D013696:Temperature
chemical_list: D000438:Alcohols; D000480:Alkynes; D001386:Azides; D010618:Phenanthrolines; D012997:Solvents; D003300:Copper; D015761:4-Aminopyridine; D009584:Nitrogen; C003885:4-dimethylaminopyridine