Effect of oil-based calcium hydroxide (Osteoinductal) on distraction osteogenesis in rabbit mandible.
OBJECTIVE
The objective of this study was to evaluate the effects of oil-based calcium hydroxide on mandibular lengthening during distraction osteogenesis.


METHODS
Twenty-four New Zealand white rabbits underwent unilateral mandibular osteotomy. The rabbits were divided into 4 groups containing 6 each: groups 1 and 3 were control groups and groups 2 and 4 were test groups. Oil-based calcium hydroxide suspension was applied to test groups' corticotomy gap after osteotomy during operation. No treatment was applied to the control groups. After 5 days' latency period, distraction was commenced at a rate of 0.8 mm/day for 10 days via custom-made distractor. Groups 1 and 2 were killed 14 days after distraction and groups 3 and 4 were killed 28 days after distraction.


RESULTS
Quantitative computerized tomography evaluation did not demonstrate a difference mean the density and the area of the regeneration between groups 1 and 3, but there was a significant difference groups 2 and 4. Histomorphometric evaluation demonstrated that there was a significant difference between test and control groups in new bone volume formation during distraction osteogenesis.


CONCLUSIONS
Application of oil-based calcium hydroxide paste during the osteotomy phase of distraction osteogenesis increased regeneration and new bone volume formation.
Polat
Hidayet Burak
HB
Department of Oral and Maxillofacial Surgery, School of Dentistry, Cumhuriyet University, Sivas, Turkey. hidayetpolat@yahoo.com
Yeler
Hasan
H
Gumus
Cesur
C
Bulut
Huseyin Eray
HE
Kucuk
Dervishan
D
D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000494:pharmacology*; D002146:Bony Callus / Q000187:drug effects; D002126:Calcium Hydroxide / Q000494:pharmacology*; D019186:Mandibular Advancement / Q000379:methods*; D010012:Osteogenesis / Q000187:drug effects*; D019857:Osteogenesis, Distraction / Q000379:methods*; D011817:Rabbits
D018786:Bone Substitutes; C112450:Osteoinductal; D002126:Calcium Hydroxide