Helicobacter pylori-negative nonsteroidal anti-inflammatory drug-negative ulcer.
The most important clinical point for dyspeptic H pylori-negative NSAID-absent negative ulcers is to adequately ensure that these common risk factors are indeed absent. Once that is done, further investigations to include the rare causes of ulcer disease need to be performed and exclusion of underlying malignancy ensured. The possibility of the Zollinger Ellison syndrome should be considered, remembering that proton pump inhibitor therapy will mitigate its classical, clinical features.
McColl
Kenneth E L
KE
Medical Sciences, Gardiner Institute, Western Infirmary, Glasgow, Scotland, G11 6NT, UK. k.e.l.mccoll@clinmed.gla.ac.uk
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003937:Diagnosis, Differential; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000209:etiology / Q000382:microbiology; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis; D016480:Helicobacter pylori; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology; D015995:Prevalence; D012307:Risk Factors; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000382:microbiology; D015043:Zollinger-Ellison Syndrome / Q000175:diagnosis
D000894:Anti-Inflammatory Agents, Non-Steroidal