title: Tonotopic reorganization of developing auditory brainstem circuits.
abstract: A fundamental organizing principle of auditory brain circuits is tonotopy, the orderly representation of the sound frequency to which neurons are most sensitive. Tonotopy arises from the coding of frequency along the cochlea and the topographic organization of auditory pathways. The mechanisms that underlie the establishment of tonotopy are poorly understood. In auditory brainstem pathways, topographic precision is present at very early stages in development, which may suggest that synaptic reorganization contributes little to the construction of precise tonotopic maps. Accumulating evidence from several brainstem nuclei, however, is now changing this view by demonstrating that developing auditory brainstem circuits undergo a marked degree of refinement on both a subcellular and circuit level.
authors.affiliation: Department of Otolaryngology, University of Pittsburgh School of Medicine, Eye and Ear Institute, Pittsburgh, Pennsylvania, USA. kkarl@pitt.edu
authors.forename: Karl
authors.initials: K
authors.lastname: Kandler
authors.forename: Amanda
authors.initials: A
authors.lastname: Clause
authors.forename: Jihyun
authors.initials: J
authors.lastname: Noh
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000033:anatomy & histology / Q000254:growth & development*; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D001933:Brain Stem / Q000033:anatomy & histology / Q000254:growth & development*; D003051:Cochlea / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D009847:Olivary Nucleus / Q000033:anatomy & histology / Q000254:growth & development; D010898:Pitch Perception / Q000502:physiology