title: Antimicrobial and cytotoxic activities of Malaysian endophytes.
abstract: Endophytes, which are receiving increasing attention, have been found to be potential sources of bioactive metabolites following the discovery of paclitaxel producing endophytic fungi. In the present study, a total of 348 endophytes were isolated from different parts of 24 Malaysian medicinal plants. Three selected endophytes (HAB10R12, HAB11R3 and HAB21F25) were investigated for their antimicrobial and cytotoxic activities. For antimicrobial activity, HAB10R12 and HAB11R3 were found to be most active against bacteria and fungi, respectively. Their antimicrobial effects were comparable to, if not better than, a number of current commercial antibacterial and antifungal agents. Both HAB10R12 and HAB21F25 were found to be potential anticancer drug candidates, having potent activity against MCF-7 and HCT116 cell lines and warrant further investigation.
authors.affiliation: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor Darul Ehsan, Malaysia. kalav922@salam.uitm.edu.my
authors.forename: Kalavathy
authors.initials: K
authors.lastname: Ramasamy
authors.forename: Siong Meng
authors.initials: SM
authors.lastname: Lim
authors.forename: Hamidah
authors.initials: H
authors.lastname: Abu Bakar
authors.forename: Noorliana
authors.initials: N
authors.lastname: Ismail
authors.forename: Maria Suhana
authors.initials: MS
authors.lastname: Ismail
authors.forename: Muhamad Fuad
authors.initials: MF
authors.lastname: Ali
authors.forename: Jean-Frédéric Faizal
authors.initials: JF
authors.lastname: Weber
authors.forename: Anthony L J
authors.initials: AL
authors.lastname: Cole
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000935:Antifungal Agents / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D006801:Humans; D008296:Malaysia; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts