title: UVA/B-induced formation of free radicals from decabromodiphenyl ether.
abstract: Polybrominated diphenyl ether (PBDE) flame retardants are ubiquitous in the environment and in humans. A deca-bromodiphenyl ether mixture (deca-BDE) is the dominating commercial PBDE product today. Deca-BDE is degraded by UV to PBDEs with fewer bromines. We hypothesized that photodegradation of deca-BDE results in the formation of free radicals. We employed electron paramagnetic resonance (EPR) with spin trap agents to examine the free radicals formed from UV irradiation of a deca-BDE mixture (DE-83R). The activating wavelength for deca-BDE photochemistry was in the UVA to UVB range. The yields of radicals from irradiated deca-BDE in tetrahydrofuran, dimethylformamide, and toluene were about 9-, 4-, and 7-fold higher, respectively, than from irradiated solvent alone. Radical formation increased with deca-BDE concentration and irradiation time. The quantum yield of radical formation of the deca-BDE mixture was higher than with an octa-BDE mixture (DE-79; approximately 2-fold), decabromobiphenyl (PBB 209; approximately 2-fold), decachlorobiphenyl (PCB 209; approximately 3-fold), and diphenyl ether (DE; approximately 6-fold), indicating the positive effects of bromine and an ether bond on radical formation. Analysis of hyperfine splittings of the spin adducts suggests that radical formation is initiated or significantly enhanced by debromination paired with hydrogen abstraction from the solvents. To our knowledge this is the first study that uses EPR to demonstrate the formation of free radicals during the photolytic degradation of PBDEs. Our findings strongly suggestthe potential of negative consequences due to radical formation during UV exposure of PBDEs in biological systems.
authors.affiliation: Department of Occupational and Environmental Health, Interdisciplinary Graduate Program in Human Toxicology, Free Radical and Radiation Biology Program, ESR Facility, and Hygienic Laboratory, The University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Yang-Won
authors.initials: YW
authors.lastname: Suh
authors.forename: Garry R
authors.initials: GR
authors.lastname: Buettner
authors.forename: Sujatha
authors.initials: S
authors.lastname: Venkataraman
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Treimer
authors.forename: Larry W
authors.initials: LW
authors.lastname: Robertson
authors.forename: Gabriele
authors.initials: G
authors.lastname: Ludewig
mesh_terms: D005609:Free Radicals; D055768:Halogenated Diphenyl Ethers / Q000737:chemistry*; D010777:Photochemistry; D013113:Spin Labels; D014466:Ultraviolet Rays
chemical_list: D005609:Free Radicals; D055768:Halogenated Diphenyl Ethers; D013113:Spin Labels; C010902:decabromobiphenyl ether