Toward generic models of hemoproteins.
The versatility of a resorcinol-substituted phenanthroline-strapped porphyrin was enhanced by appending allyl chains via a double Claisen rearrangement. Two pyridine arms were then appended to the resorcinol oxygens. This multifunctional porphyrin is a suitable generic building block for the preparation of liposoluble heme protein models. X-ray characterization of the pentacoordinated zinc complex and the binding of a sixth imidazole ligand to the ferric complex both suggest a facilitated access to an empty distal site.
Lo
Mamadou
M
Chimie des Ligands à Architecture Contrôlée (CLAC), Institut de Chimie, UMR 7177 CNRS-Université de Strasbourg,.4 rue Blaise Pascal, 67008 Strasbourg Cedex, France.
Mahajan
Dinesh
D
Wytko
Jennifer A
JA
Boudon
Corinne
C
Weiss
Jean
J
D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000737:chemistry; D006420:Hemeproteins / Q000737:chemistry*; D008024:Ligands; D008665:Metalloporphyrins / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010618:Phenanthrolines / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D012118:Resorcinols / Q000737:chemistry*; D015032:Zinc
D005290:Ferric Compounds; D006420:Hemeproteins; D008024:Ligands; D008665:Metalloporphyrins; D010618:Phenanthrolines; D011725:Pyridines; D012118:Resorcinols; D015032:Zinc