title: Novel nano-composite multi-layered biomaterial for the treatment of multifocal degenerative cartilage lesions.
abstract: We report on a 46-year-old athletic patient, previously treated with anterior cruciate ligament reconstruction, with large degenerative chondral lesions of the medial femoral condyle, trochlea and patella, which was successfully treated with a closing-wedge high tibial osteotomy and the implant of a newly developed biomimetic nanostructured osteochondral bioactive scaffold. After 1 year of follow-up the patient was pain-free, had full knee range of motion, and had returned to his pre-operation level of athletic activity. MRI evaluation at 6 months showed that the implant gave a hyaline-like signal as well as a good restoration of the articular surface, with minimal subchondral bone oedema. Subchondral oedema was almost non-visible at 12 months.
authors.affiliation: Department of Orthopaedic and Sports Trauma, Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, Bologna 40136, Italy. e.kon@biomec.ior.it
authors.forename: Elizaveta
authors.initials: E
authors.lastname: Kon
authors.forename: M
authors.initials: M
authors.lastname: Delcogliano
authors.forename: G
authors.initials: G
authors.lastname: Filardo
authors.forename: G
authors.initials: G
authors.lastname: Altadonna
authors.forename: M
authors.initials: M
authors.lastname: Marcacci
mesh_terms: D001182:Arthroscopy; D001672:Biocompatible Materials; D002357:Cartilage Diseases / Q000601:surgery*; D002358:Cartilage, Articular / Q000293:injuries*; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049329:Nanostructures; D010027:Osteotomy; D019919:Prosthesis Implantation; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials