Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system.
Nesfatin-1 is a recently discovered hypothalamic peptide that was shown to suppress food intake through a melanocortin-3/4 receptor-dependent mechanism. Since nesfatin-1 mRNA is detected in the paraventricular nucleus of the hypothalamus, and because many peptides that alter food intake also influence cardiovascular function, we tested the ability of centrally administered nesfatin-1 to affect mean arterial pressure (MAP) in conscious, freely moving rats. Significant increases in MAP were observed following intracerebroventricular administration of nesfatin-1. Pretreatment with either the melanocortin-3/4 receptor antagonist, SHU9119 (intracerebroventricular), or the alpha-adrenergic antagonist, phentolamine (intra-arterial), abrogated the rise in MAP induced by nesfatin-1, indicating that nesfatin-1 may interact with the central melanocortin system to increase sympathetic nerve activity and lead to an increase in MAP. Thus we have identified a novel action of nesfatin-1, in addition to its anorexigenic effects, to stimulate autonomic nervous system activity.
Yosten
Gina L C
GL
Saint Louis Univ., Dept. of Pharmacological and Physiological Science, 1402 S. Grand Blvd., St. Louis, MO 63104, USA. gyosten@slu.edu
Samson
Willis K
WK
D000818:Animals; D001007:Anxiety / Q000139:chemically induced; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002135:Calcium-Binding Proteins; D002319:Cardiovascular System / Q000187:drug effects*; D004268:DNA-Binding Proteins; D004326:Drinking / Q000187:drug effects / Q000502:physiology; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005215:Fasting / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D000080866:Nucleobindins; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D044101:Receptors, Melanocortin / Q000037:antagonists & inhibitors / Q000502:physiology*; D013037:Spatial Behavior / Q000187:drug effects
D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C000630652:Nucb1 protein, rat; D000080866:Nucleobindins; D044101:Receptors, Melanocortin; C103272:SHU 9119; D009074:Melanocyte-Stimulating Hormones; D010646:Phentolamine