[Surfactant protein D as a biomarker for lung injury].
Respiratory distress and the need for mechanical ventilation, have been the most common reasons for ITU hospitalization. Pulmonary pathology is sometimes difficult to diagnose and differentiate; therefore we are on a continuous search for diagnostic tools and markers. It has been suggested that in patients intubated for acute lung injury, lower concentrations of surfactant proteins A and D in bronchoalveolar fluid and higher concentrations in the plasma are associated with more severe lung injury and worse clinical outcomes. Surfactant protein D (SP-D) plays a crucial role in defense mechanisms and immunomodulation, binding with various pathogens such as bacteria, fungi and viruses. SP-D is a valuable marker in ARDS and other specific and non-specific pulmonary pathologies, and may find a place as a valuable marker of the severity of disease.
Czechowski
Mariusz
M
Klinika Anestezjologii i Intensywnej Terapii Slaskiego UM w Katowicach. mariuszczechow@poczta.onet.pl
Karpel
Ewa
E
Duda
Izabela
I
Grzybowska
Konstancja
K
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D055370:Lung Injury / Q000175:diagnosis* / Q000378:metabolism*; D037662:Pulmonary Surfactant-Associated Protein A / Q000378:metabolism; D037663:Pulmonary Surfactant-Associated Protein D / Q000378:metabolism*
D015415:Biomarkers; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D