Postoperative cardiac troponin I is an independent predictor of in-hospital death after coronary artery bypass grafting.
OBJECTIVE
All types of cardiac surgery involve considerable injury to the myocardium. However, little is known about the prognostic value of cardiac troponin (cTnI), which is a cardiac-specific biologic marker. The purpose of this prospective study was to evaluate the prognostic value of cTnI concentrations measured 20 hours after the end of surgery in patients undergoing coronary bypass grafting (CABG).


METHODS
Three hundred twenty consecutive patients undergoing CABG surgery during an 18-month period were enrolled. In-hospital death (N.=10), cause of death, major clinical outcomes, and relationship between cTnI concentrations and clinical outcome were recorded.


RESULTS
cTnI concentration was an independent predictor of in-hospital mortality (cTnI >14 ng/mL, P<0.05). The perioperative and postoperative variables independently associated with in-hospital death were female gender, combined surgery, ejection fraction <30%, cardiopulmonary bypass duration, and total chest tube drainage volume.


CONCLUSIONS
Our study indicates that cTnI concentration 20 hours after the end of surgery is an independent predictor of in-hospital death after CABG. Furthermore, high concentrations of cTnI were associated with a cardiac cause of death and major clinical outcomes.
Hashemzadeh
K
K
Department of Cardiovascular Surgery, Shahid Madani Cardiovascular Research Center, Tabriz University of Medical Sciences, Iran. khhashemzadeh41@yahoo.com
Dehdilani
M
M
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000401:mortality; D002423:Cause of Death; D001026:Coronary Artery Bypass / Q000401:mortality*; D004322:Drainage / Q000401:mortality; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013318:Stroke Volume; D013997:Time Factors; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood*; D015854:Up-Regulation
D015415:Biomarkers; D019210:Troponin I