Trypanosoma evansi: hematologic changes in experimentally infected cats.
This study aimed at evaluating hemogram and erythropoietic changes in cats experimentally infected with Trypanosoma evansi. Thirteen adult female non-breeding Felix catus were separated into two groups: seven animals were infected with 10(8) trypomastigotes each, and six animals were used as negative controls. Animals were kept in air-conditioned rooms and blood smears were performed daily for 49 days. Blood samples were collected from the jugular vein at days 0, 7, 21, 35 and 49 and stored in blood-collecting tubes containing anticoagulant. Bone marrow was collected from the proximal epiphysis of the right femur at days 14 and 42 post-inoculation (PI). Total erythrocyte count, hematocrit and hemoglobin showed statistical differences among groups from the seventh day PI onwards (P<0.05). The mean corpuscular volume and the mean corpuscular hemoglobin concentration remained normal, characterizing a normocytic-normochromic anemia. Reticulocyte count increased in the infected group from the 21st day onwards, but remained near normal values suggesting a mild regenerative anemia. Moreover, the myeloid:erythroid ratio significantly reduced at day 42 PI, evidencing a bone marrow hematopoietic response. Based on these results we conclude that cats infected with T. evansi have normocytic, normochromic, regenerative anemia.
Da Silva
Aleksandro Schafer
AS
Veterinary Medicine, Universidade Federal de Santa Maria, 97105-900, Santa Maria - RS, Brazil. aleksandro_ss@yahoo.com.br
Costa
Márcio Machado
MM
Wolkmer
Patrícia
P
Zanette
Régis Adriel
RA
Faccio
Luciana
L
Gressler
Lucas Trevisan
LT
Dorneles
Tagor Eduardo Andreolla
TE
Santurio
Janio Morais
JM
Lopes
Sonia Terezinha dos Anjos
ST
Monteiro
Silvia Gonzalez
SG
D000740:Anemia / Q000097:blood / Q000209:etiology*; D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D002415:Cats; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D004920:Erythropoiesis; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D018512:Parasitemia / Q000097:blood*; D017701:Reticulocyte Count; D014352:Trypanosomiasis / Q000097:blood* / Q000150:complications*
D006454:Hemoglobins