title: Intractable cardiogenic shock in stress cardiomyopathy with left ventricular outflow tract obstruction: is extra-corporeal life support the best treatment?
abstract: We report the use of extra-corporeal cardiopulmonary support (ECLS), in a case of complicating refractory severe cardiogenic shock, in a patient with Tako-tsubo cardiomyopathy (TC). Tako-tsubo cardiomyopathy syndrome is characterized by left ventricular (LV) wall motion abnormalities, usually without coronary artery disease, mimicking the diagnosis of acute coronary syndrome. This ventricular dysfunction is typically reversible in the acute phase, though it can progress into refractory cardiogenic shock with limited therapeutic options available. Here, we report for the first time in a Tako-tsubo patient with refractory cardiogenic shock, the use of ECLS treatment in order to unload the heart, sustain circulation and end-organ perfusion, and promote potential ventricular recovery. Extra-corporeal life support allowed inotropic drug weaning while maintaining end-organ function and supported the patient until myocardial recovery. The patient recovered completely, and a normal LV ejection fraction was documented by 2D echocardiography on day 7. From our experience, ECLS can be an appropriate treatment for severe refractory cardiogenic shock in patients with TC. Extra-corporeal life support was an effective ultimate solution.
authors.affiliation: Cardiac Surgery, Medical and Surgical Critical Care Department, University of Florence, 50134 Firenze, Italy. massimo.bonacchi@unifi.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Bonacchi
authors.forename: Massimo
authors.initials: M
authors.lastname: Maiani
authors.forename: Guy
authors.initials: G
authors.lastname: Harmelin
authors.forename: Guido
authors.initials: G
authors.lastname: Sani
mesh_terms: D000368:Aged; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006439:Hemodynamics; D006801:Humans; D020127:Recovery of Function; D012770:Shock, Cardiogenic / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D013318:Stroke Volume; D054549:Takotsubo Cardiomyopathy / Q000150:complications / Q000628:therapy*; D018487:Ventricular Dysfunction, Left / Q000628:therapy; D016277:Ventricular Function, Left; D014694:Ventricular Outflow Obstruction / Q000150:complications / Q000628:therapy*