[Therapeutic effect of para-toluenesulfonamide on transplanted hepatocarcinoma in nude mice].
OBJECTIVE
To study the effect of of percutaneous para-toluenesulfonamide (PTS) injection on transplanted hepatocarcinoma in nude mice.


METHODS
Sixty nude mice with subcutaneous transplanted hepatocarcinoma were randomized into 6 groups, namely PTS, chemotherapy, radiotherapy, PTS+chemotherapy, PTS+radiotherapy and control groups. PTS were injected into the tumor in the nude mouse models as indicated, and the tumor growth rate and survival time of the mice were recorded.


RESULTS
All the treatments resulted in effective arrest of the tumor growth, but the effects of PTS+chemotherapy and PTS+radiotherapy were more obvious. No significant difference in the survival time of the mice were noted between the groups.


CONCLUSIONS
PTS+chemotherapy and PTS+radiotherapy are safe and reliable, and produces better effects than either radiotherapy or chemotherapy alone.
Meng
Hui
H
Oncology Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Li
Min-ying
MY
Zhu
Wei-liang
WL
Zhang
Ji-ren
JR
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D015552:Injections, Intralesional; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011878:Radiotherapy; D011897:Random Allocation; D013449:Sulfonamides / Q000008:administration & dosage*; D014050:Toluene / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000096926:Benzenesulfonamides
D013449:Sulfonamides; D014050:Toluene; C025417:4-toluenesulfonamide; D000096926:Benzenesulfonamides