[Recent developments in fetal surgery. Technical, organizational and ethical considerations].
Progress in prenatal diagnosis has led to more frequent detection of fetal abnormalities which, if left untreated, would be fatal or cause severe disabilities despite optimal postnatal care. Intrauterine surgery is possible in selected cases. Most procedures involve microendoscopy with local or regional analgesia. Fetal analgesia is indicated for procedures that are directly invasive for the fetus. Surgical treatment of twin-to-twin transfusion is so far the only example of successful fetal therapy, as demonstrated in a randomized controlled trial. The most severe forms of congenital diaphragmatic hernia may also benefit from temporary occlusion of the fetal trachea in order to allow lung growth and prevent pulmonary hypoplasia. The future of open fetal surgery will depend partly on the results of the ongoing MOM study of intrauterine coverage of myelomeningocele. These developments also raise ethical questions, including the competence of the surgical team, and the borderline between therapeutic innovation, experimental surgery, and standard of care. The possibility of therapeutic termination should not be overlooked.
Ville
Yves
Y
Maternité et Médecine foetale, Université Paris Descartes, CHU Necker-Enfants-Malades. yves.ville@nck.aphp.fr
D000698:Analgesia / Q000379:methods; D002585:Cesarean Section; D002986:Clinical Trials as Topic / Q000941:ethics; D004200:Diseases in Twins; D028741:Ethics Committees, Clinical; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000601:surgery*; D046128:Fetal Therapies / Q000941:ethics / Q000295:instrumentation / Q000379:methods / Q000639:trends*; D005332:Fetoscopy; D005602:France; D006548:Hernia, Diaphragmatic / Q000196:embryology / Q000601:surgery; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000196:embryology / Q000601:surgery; D020883:Hysterotomy; D007231:Infant, Newborn; D007813:Laparotomy; D008591:Meningomyelocele / Q000196:embryology / Q000601:surgery; D010500:Perinatology / Q000458:organization & administration; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011296:Prenatal Diagnosis / Q000379:methods; D011666:Pulmonary Valve Stenosis / Q000196:embryology / Q000601:surgery; D014430:Twins, Monozygotic