title: Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population.
abstract: We report a significantly higher occurrence of HLA-DRB1*09 (51% vs. 23%, P = 0.002, OR = 3.57) and HLA-B*46-DRB1*09 (26% vs. 8%, P = 0.018, OR = 3.76) in patients with haemorrhagic fever with renal syndrome (HFRS) compared to the control group, suggesting Hantaan virus-induced HFRS is associated with a genetic predisposition in the Chinese Han population.
authors.affiliation: Department of Immunology, Fourth Military Medical University, 17 Changle West Road, Xi'an, China.
authors.forename: M L
authors.initials: ML
authors.lastname: Wang
authors.forename: J H
authors.initials: JH
authors.lastname: Lai
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.forename: H B
authors.initials: HB
authors.lastname: Zhang
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: J P
authors.initials: JP
authors.lastname: Wang
authors.forename: Y M
authors.initials: YM
authors.lastname: Li
authors.forename: A G
authors.initials: AG
authors.lastname: Yang
authors.forename: B Q
authors.initials: BQ
authors.lastname: Jin
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D018063:Hantaan virus; D006239:Haplotypes / Q000235:genetics; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D016015:Logistic Models; D012189:Retrospective Studies
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains