Ghrelin and its biological effects on pigs.
Ghrelin is a 28 amino acid peptide, which produces its marked effects through binding to the endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Based on the contemporary literatures, it was shown that ghrelin was involved in a series of biological functions including regulation of food intake, body weight, gastrointestinal (GI) motility, hormone secretion, glucose release, cardiovascular functions, enzyme release, cell proliferation and reproduction in pigs through binding to GHS-R 1a or unidentified receptors. It was also observed that ghrelin induced adipocyte and hepatocyte proliferation of primary cultured piglet. In this paper, recent research on ghrelin structure, distribution, GHS-R receptor, biological functions and its regulatory mechanisms for pigs are presented.
Dong
Xiao-Ying
XY
College of Yingdong Bioengineering, Shaoguan University, Zhenjiang District, Shaoguan, Guangdong, China.
Xu
Jian
J
Tang
Sheng-Qiu
SQ
Li
Hai-Yun
HY
Jiang
Qing-Yan
QY
Zou
Xiao-Ting
XT
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects; D054439:Ghrelin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D054440:Receptors, Ghrelin / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D013552:Swine / Q000502:physiology*
D054439:Ghrelin; D054440:Receptors, Ghrelin; D005947:Glucose