Synthesis, characterization, crystal structure and antibacterial activities of transition metal(II) complexes of the schiff base 2-[(4-methylphenylimino)methyl]-6-methoxyphenol.
Five transition metal(II) complexes, [ML(2)Cl(2)] 1 approximately 5, were synthesized from the reaction of MCl(2) x nH(2)O (M = Mn, Co, Ni, Cu, Cd) and the Schiff base ligand 2-[(4-methylphenylimino)methyl]-6-methoxyphenol (C(15)H(15)NO(2), L), obtained by condensation of o-vanillin (2-hydroxy-3-methoxybenzaldehyde) with p-toluidine. They were characterized by elemental analysis, molar conductance, FT-IR spectra, thermal analysis. The structure of complex 1 was determined by single-crystal X-ray diffraction. Its crystal structure is of monoclinic system, space group P2(1)/c with a = 9.0111(18) A, b = 11.222(2) A, c =28.130 (6) A, alpha = 90 masculine, beta = 92.29(3) masculine, gamma = 90 masculine, V = 2867.6(10) A(3), Z = 4. The Mn atom is six-coordinate and displays distorted octahedral geometry.The Schiff base ligand and its complexes have been tested in vitro to evaluate their antibacterial activity against bacteria, viz., Escherichia coli, Staphylococcus aureus and Bacillus subtilis. It has been found that the complexes have higher activity than the corresponding free Schiff base ligand against the same bacteria.
Yu
Yu-Ye
YY
Jinhua College of Profession & Technology, Jinhua, PR China. jhyuyy@126.com
Xian
Hui-Duo
HD
Liu
Jian-Feng
JF
Zhao
Guo-Liang
GL
D031722:Andropogon / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D018360:Crystallography, X-Ray; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013818:Thermogravimetry; D028561:Transition Elements / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D010636:Phenols; D012545:Schiff Bases; D028561:Transition Elements