Along a TNF-paved road from dead parasites in red cells to cerebral malaria, and beyond.
This is a personal account of how tumour necrosis factor (TNF) the prototype of a group of host-origin mediators, often known as pro-inflammatory cytokines, came into parasitology, and was subsequently realised to be central to the pathogenesis of most disease pathology. This contribution summarizes an example of how a curiosity-driven outsider, with initially no intention of heading this way, and no relevant experience, and with no more than the simplest of plans but an ambition to read as widely as it takes, and (most importantly) allowed to follow his head, can be what is required to give fresh insight into understanding a disease. It also gives the author's views on aspects of how the field of malaria disease pathogenesis seems to be developing. The hope is to inspire another generation to follow a similarly original course.
Clark
I A
IA
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia. ian.clark@anu.edu.au
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology*; D006790:Host-Parasite Interactions / Q000276:immunology; D016779:Malaria, Cerebral / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology*; D016778:Malaria, Falciparum / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology; D010963:Plasmodium falciparum / Q000276:immunology / Q000472:pathogenicity; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha