Closing the ring: a new twist to bacterial chromosome condensation.
The mechanisms underlying chromosome organization in bacteria are still shrouded in mystery. Sullivan et al. (2009) and Gruber and Errington (2009) now report that the DNA-binding protein ParB ensures proper arrangement and partitioning of chromosomal DNA in Bacillus subtilis by recruiting the condensin SMC to the replication origin region.
Thanbichler
Martin
M
Independent Junior Research Group Prokaryotic Cell Biology, Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Strasse, D-35043 Marburg, Germany. thanbichler@mpi-marburg.mpg.de
D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D001412:Bacillus subtilis / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002876:Chromosomes, Bacterial / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; C108312:condensin complexes; D000251:Adenosine Triphosphatases