title: The amyloid hypothesis for Alzheimer's disease: a critical reappraisal.
abstract: The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer's disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid-beta precursor protein (APP) and think how this may relate to the cell death in the disease process.
authors.affiliation: Reta Lilla Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK. j.hardy@ion.ucl.ac.uk
authors.forename: John
authors.initials: J
authors.lastname: Hardy
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D023582:Alzheimer Vaccines / Q000009:adverse effects; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology*; D002536:Cerebral Arteries / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D002986:Clinical Trials as Topic / Q000379:methods / Q000592:standards; D018450:Disease Progression; D006801:Humans; D009410:Nerve Degeneration / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology
chemical_list: D023582:Alzheimer Vaccines; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor