title: Radioimmunotherapy and secondary leukemia: a case report.
abstract: This study describes a patient with a relapsed, diffuse, large B cell lymphoma (DLBCL) treated with radioimmunotherapy (RIT) with yttrium-90 ((90)Y)-ibritumomab tiuxetan (Zevalin) who 5 months later developed acute myeloid leukemia (AML) with inversion of chromosome 16. Our data indicate that molecular biological techniques should be used in selected cases to integrate data obtained with standard cytogenetics: using RT-PCR we showed that inversion of chromosome 16 was already present before RIT, in striking contrast to the normal karyotype found with conventional cytogenetics. This approach will allow investigators to avoid misleading data and provide support for conclusions regarding the side effects of treatment.
authors.forename: Michele
authors.initials: M
authors.lastname: Magni
authors.forename: Massimo
authors.initials: M
authors.lastname: Di Nicola
authors.forename: Adele
authors.initials: A
authors.lastname: Testi
authors.forename: Antonello
authors.initials: A
authors.lastname: Cabras
authors.forename: Liliana
authors.initials: L
authors.lastname: Devizzi
authors.forename: Anna
authors.initials: A
authors.lastname: Guidetti
authors.forename: Paola
authors.initials: P
authors.lastname: Matteucci
authors.forename: Simonetta
authors.initials: S
authors.lastname: Viviani
authors.forename: Valeria
authors.initials: V
authors.lastname: Bonfante
authors.forename: Cristiana
authors.initials: C
authors.lastname: Carniti
authors.forename: Irene
authors.initials: I
authors.lastname: Ricca
authors.forename: Antonino
authors.initials: A
authors.lastname: Carbone
authors.forename: Carmelo
authors.initials: C
authors.lastname: Carlo-Stella
authors.forename: Alessandro M
authors.initials: AM
authors.lastname: Gianni
mesh_terms: D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology* / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016499:Radioimmunotherapy / Q000009:adverse effects*; D020133:Reverse Transcriptase Polymerase Chain Reaction