title: Rifampin and linezolid in the treatment of methicillin-resistant Staphylococcus aureus preseptal cellulitis.
abstract: Methicillin-resistant Staphylococcus aureus (MRSA) preseptal cellulitis is an aggressive ophthalmic infection of increasing frequency. Previously reported cases were successfully treated with first line drugs such as vancomycin or Bactrim (trimethoprim and sulfamethoxazole); however, such drugs have limited efficacy in treating cutaneous MRSA. The authors report the first 2 known cases of MRSA-mediated preseptal cellulitis that resolved with systemic linezolid and rifampin following failed intravenous vancomycin treatment after incision and drainage of the abscess. The authors conclude that in cases of cutaneous MRSA infections that respond poorly to vancomycin, linezolid and rifampin combination therapy may provide an alternative therapeutic option.
authors.affiliation: Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Simon R
authors.initials: SR
authors.lastname: Bababeygy
authors.forename: Ruwan A
authors.initials: RA
authors.lastname: Silva
authors.forename: Young
authors.initials: Y
authors.lastname: Sun
authors.forename: Atul
authors.initials: A
authors.lastname: Jain
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002481:Cellulitis / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D004359:Drug Therapy, Combination; D015818:Eye Infections, Bacterial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus; D023303:Oxazolidinones / Q000627:therapeutic use*; D019233:Retreatment; D012293:Rifampin / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014640:Vancomycin / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid; D012293:Rifampin