Mutation accumulation, soft selection and the middle-class neighborhood.
The "middle-class neighborhood" is a breeding design intended to allow new mutations to accumulate by lessening the effects of purifying selection through the elimination of among-line fitness variation. We show that this design effectively applies soft selection to the experimental population, potentially causing biased estimates of mutational effects if social effects contribute to fitness.
Moorad
Jacob A
JA
Department of Genetics, University of Georgia, Athens, Georgia 30602-7223, USA. jmoorad@uga.edu
Hall
David W
DW
D000818:Animals; D001947:Breeding; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D012641:Selection, Genetic; D012924:Social Conditions