title: Effects of electro-acupuncture on IGF-I expression in spared dorsal root ganglia and associated spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomies.
abstract: The effects of electro-acupuncture (EA) on insulin-like growth factor-I (IGF-I) expression in the spared dorsal root ganglia (DRG) and associated spinal dorsal horns were explored in cats subjected to unilateral removal of L(1)-L(5) and L(7)-S(2) DRG, sparing the L(6) DRG. Immunohistochemistry revealed the presence of IGF-I immunoreactive products in the L(6) DRG neurons and some neurons and glial cells in the spinal cord. Western blot demonstrated that the level of IGF-I was significantly up-regulated both in the spared DRG and the dorsal horns of L(3) and L(6) cord segments at both 7 and 14 days post operation following EA. The present findings demonstrated the association between neuroplasticity and IGF-I expression, suggesting the possible role of IGF-I in EA promoted spinal cord plasticity.
authors.affiliation: Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Dai
authors.forename: Zhao-Jun
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Sun
authors.forename: Jiang-xia
authors.initials: JX
authors.lastname: Pang
authors.forename: Chao
authors.initials: C
authors.lastname: You
authors.forename: Ting-Hua
authors.initials: TH
authors.lastname: Wang
mesh_terms: D000818:Animals; D002415:Cats; D015671:Electroacupuncture; D005727:Ganglia, Spinal / Q000378:metabolism*; D015171:Ganglionectomy; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D008297:Male; D009457:Neuroglia / Q000378:metabolism; D009473:Neuronal Plasticity; D020671:Posterior Horn Cells / Q000378:metabolism*
chemical_list: D007334:Insulin-Like Growth Factor I