title: Is there a link between insulin resistance and inflammatory activation in preeclampsia?
abstract: Preeclampsia is a severe complication of human pregnancy and an insulin resistant state has been demonstrated in this multisystem disorder, although its bases remain unclear. Inositol phosphoglycans P-type belongs to a family of putative insulin mediators and was described to exert many insulin-like effects on lipid and glucose metabolism. A definite association between this molecule and preeclampsia was reported. The systemic inflammatory activation that occurs in preeclampsia as a consequence of the immunological dysfunction can exacerbate placental insulin resistance leading to an over-expression of P-IPG as a counterregulatory mechanism to insulin resistance. Besides, the lipidic form of P-IPG was reported to be similar to endotoxins, and may represent the link between insulin resistance, systemic inflammation and increased angiogenic factors. In this article we propose a new working theory on insulin resistance and preeclampsia.
authors.affiliation: Department of Obstetrics and Gynaecology, Sacro Cuore Don Calabria General Hospital, Negrar, Verona, Italy. marcoscioscia@gmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Scioscia
authors.forename: Pantaleo
authors.initials: P
authors.lastname: Greco
authors.forename: Luigi E
authors.initials: LE
authors.lastname: Selvaggi
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Rademacher
mesh_terms: D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology*; D007333:Insulin Resistance; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy