title: A novel diagram and complement to the CONSORT chart for presenting multimodal clinical trials.
abstract: We developed a novel diagram to depict patient flow and outcomes in clinical trials. In contrast to flow diagrams such as the CONSORT chart, our diagram enables individual patient histories to be traced and depicts important patterns of treatment administration and outcomes, such as response and adverse events. Also, it is particularly useful for multimodal treatments or a sequence of different therapies where the CONSORT flow chart is less informative and can be confusing.
authors.affiliation: Swiss Group for Clinical Cancer Research (SAKK), Berne, Switzerland. jan.schuller@sakk.ch
authors.forename: Jan C
authors.initials: JC
authors.lastname: Schuller
authors.forename: Michael
authors.initials: M
authors.lastname: Mayer
authors.forename: Doris
authors.initials: D
authors.lastname: Lanz
authors.forename: Shu-Fang Hsu
authors.initials: SF
authors.lastname: Schmitz
authors.forename: Peter
authors.initials: P
authors.lastname: Brauchli
authors.forename: Nicolas
authors.initials: N
authors.lastname: Leupin
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D017322:Clinical Trials, Phase II as Topic / Q000379:methods; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care / Q000379:methods; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012984:Software; D012985:Software Design