Nutrigenomic targeting of carbohydrate craving behavior: can we manage obesity and aberrant craving behaviors with neurochemical pathway manipulation by Immunological Compatible Substances (nutrients) using a Genetic Positioning System (GPS) Map?
Genetic mediated physiological processes that rely on both pharmacological and nutritional principles hold great promise for the successful therapeutic targeting of reduced carbohydrate craving, body-friendly fat loss, healthy body recomposition, and overall wellness. By integrating an assembly of scientific knowledge on inheritable characteristics and environmental mediators of gene expression, we review the relationship of genes, hormones, neurotransmitters, and nutrients as they correct unwanted weight gain coupled with unhappiness. In contrast to a simple one-locus, one-mechanism focus on pharmaceuticals alone, we hypothesize that the use of nutrigenomic treatment targeting multi-physiological neurological, immunological, and metabolic pathways will enable clinicians to intercede in the process of lipogenesis by promoting lipolysis while attenuating aberrant glucose cravings. In turn, this approach will enhance wellness in a safe and predictable manner through the use of a Genetic Positioning System (GPS) Map. The GPS Map, while presently incomplete, ultimately will serve not only as a blueprint for personalized medicine in the treatment of obesity, but also for the development of strategies for reducing many harmful addictive behaviors and promoting optimal health by using substances compatible with the body's immune system.
Downs
B William
BW
Department of Nutrigenomics and Personalized Medicine, LifeGen, Inc., La Jolla, CA, USA.
Chen
Amanda L C
AL
Chen
Thomas J H
TJ
Waite
Roger L
RL
Braverman
Eric R
ER
Kerner
Mallory
M
Braverman
Dasha
D
Rhoades
Patrick
P
Prihoda
Thomas J
TJ
Palomo
Tomas
T
Oscar-Berman
Marlene
M
Reinking
Jeffrey
J
Blum
Seth H
SH
DiNubile
Nicholas A
NA
Liu
H H
HH
Blum
Kenneth
K
D002874:Chromosome Mapping / Q000379:methods; D004040:Dietary Carbohydrates; D005247:Feeding Behavior; D001068:Feeding and Eating Disorders / Q000235:genetics* / Q000517:prevention & control*; D018390:Gene Targeting / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009765:Obesity / Q000235:genetics* / Q000517:prevention & control*; D015398:Signal Transduction / Q000235:genetics
D004040:Dietary Carbohydrates