title: Human-urine diabetes assay and in vivo rat bladder assay using a fluorine-doped carbon nanotube catheter sensor.
abstract: The creation of a novel biosensor consisting of a fluorine-doped carbon nanotube (FCN) was explored for use in cyclic voltammetric (CV) and square-wave stripping voltammetric (SW) glucose assay. In the experiment that was carried out in this study, analytical optimum conditions were attained at the low detection limit (S/N3) of 0.6 microg/L (3.3 x 10(-9) M). In the 0.1 mg/L spike, the relative standard deviation of 0.607 (n = 15) was obtained. This was used for the diagnosis of the urine of patients with diabetes. Moreover, the catheter-type electrode (CE) can be inserted into a rat bladder through the rat's organs. Thus, it can be connected with an electrochemical analyzer that can be fitted with an interface for the real-time in vivo analysis of metabolic glucose. The developed system can be used for organ treatment, biological analysis, and in vivo control.
authors.affiliation: Biosensor Research Institute, Seoul National University of Technology, Seoul, South Korea. suwyoung@snut.ac.kr
authors.forename: Suw Young
authors.initials: SY
authors.lastname: Ly
authors.forename: Jin Hui
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D002408:Catheters, Indwelling; D017076:Computer-Aided Design; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000652:urine*; D004563:Electrochemistry / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D005461:Fluorine / Q000737:chemistry; D005947:Glucose; D006029:Glycosuria / Q000652:urine*; D008297:Male; D036103:Nanotechnology / Q000295:instrumentation; D037742:Nanotubes, Carbon / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016482:Urinalysis / Q000295:instrumentation; D001743:Urinary Bladder / Q000378:metabolism*
chemical_list: D037742:Nanotubes, Carbon; D005461:Fluorine; D005947:Glucose