title: Nonspecific interstitial pneumonia associated with collagen vascular disease: analysis of CT features to distinguish the various types.
abstract: OBJECTIVE
  The purpose of this study was to analyze the CT findings of interstitial lung diseases that are associated with collagen vascular disease (CVD), with particular attention to nonspecific interstitial pneumonia (NSIP), and to examine whether it is possible to predict the clinical diagnosis of CVDs based on the CT findings alone.
  
  
  METHODS
  CT scans of 49 patients with NSIP associated with CVD (15 males, 34 females; mean age, 55+/-10 years; age range, 25-76 years) were included in this retrospective study. All patients underwent a surgical biopsy. The clinical diagnosis comprised rheumatoid arthritis (RA) (n=15), systemic sclerosis (SSc) (n=8), polymyositis and dermatomyositis (PM/DM) (n=18), Sjögren's syndrome (SjS) (n=4), and mixed connective tissue disease (MCTD) (n=4). Each CT was reviewed by two independent observers who made a clinical diagnosis based on the CT findings alone.
  
  
  RESULTS
  The observers made a correct diagnosis for 22 (45%) of the 49 patients. A correct diagnosis was made for: RA in 7 (47%) of 15 patients; SSc in 3 (38%) of 8 patients; PM/DM in 11 (61%) of 18 patients; SjS in 1 (25%) of 4 patients. None of the 4 MCTD cases was diagnosed.
  
  
  CONCLUSIONS
  It is difficult to make a correct clinical diagnosis of the various types of CVDs based solely on CT findings. However, it is probable to make a reasonably accurate clinical diagnosis in cases that show the typical CT findings, especially for PM/DM patients.
authors.affiliation: Department of Medicine, Division of Pulmonary Medicine, Jichi Medical University, Shimotsuke. tada0605@jichi.ac.jp
authors.forename: Tadahisa
authors.initials: T
authors.lastname: Daimon
authors.forename: Takeshi
authors.initials: T
authors.lastname: Johkoh
authors.forename: Osamu
authors.initials: O
authors.lastname: Honda
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Sumikawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ichikado
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kondoh
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Kiminori
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yanagawa
authors.forename: Atsuo
authors.initials: A
authors.lastname: Inoue
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Tomiyama
authors.forename: Hironobu
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Sugiyama
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000000981:diagnostic imaging; D003095:Collagen Diseases / Q000145:classification / Q000150:complications* / Q000000981:diagnostic imaging*; D003882:Dermatomyositis / Q000150:complications / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000150:complications / Q000000981:diagnostic imaging; D012859:Sjogren's Syndrome / Q000150:complications / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014652:Vascular Diseases / Q000145:classification / Q000150:complications* / Q000000981:diagnostic imaging*