title: The effects of carbon dioxide on measuring cerebral spinal fluid pressure.
abstract: OBJECTIVE
  The effects of pCO2 on cerebral spinal fluid (CSF) pressure measurement were observed in four patients.
  
  
  METHODS
  Children presenting with either a diagnosis or suspected diagnosis of IIH, who were undergoing lumbar puncture under a general anaesthetic for pressure measurement, were recruited to study the relationship between pCO2 and CSF pressure measurements.
  
  
  RESULTS
  A rise of end-tidal pCO2 by 1 kPa causes a rise of CSF pressure by 3.5-12 cm H20.
  
  
  CONCLUSIONS
  Controlling of pCO2 is important when measuring CSF pressure to prevent misdiagnosis and over treatment of patients with idiopathic intracranial hypertension (IIH).
authors.affiliation: Paediatric Neurology Department, Evelina Children's Hospital, Guy's and St Thomas' Hospitals NHS Foundation Trust, Lambeth Palace Road, London, SE1 7EH, UK. Ming.lim@gstt.nhs.uk
authors.forename: Ming Jin
authors.initials: MJ
authors.lastname: Lim
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Lin
mesh_terms: D002245:Carbon Dioxide; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D002648:Child; D006801:Humans; D019586:Intracranial Hypertension / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000378:metabolism; D013129:Spinal Puncture
chemical_list: D002245:Carbon Dioxide