Selective MMP-12 inhibitors: WO-2008057254.
Amino-substituted xanthene, thioxanthene and carbazole sulfonamido-carboxylic acid of carboxamido carboxylic acid derivatives, their use to treat metalloprotease mediated conditions, and especially to inhibit MMP-12, and to treat osteoarthritis, rheumatoid arthritis, atherosclerosis, heart failure, fibrosis, pulmonary emphysema, tumour growth, asthma and chronic obstructive pulmonary disorder (COPD). Compounds of this category are suggested to be particularly useful in the treatment of COPD.
Norman
Peter
P
Norman Consulting, 18 Pink Lane, Burnham, Buckinghamshire, UK. peter.norman2@btinternet.com
D000818:Animals; D002264:Carboxylic Acids / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D010330:Patents as Topic; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D013892:Thioxanthenes / Q000737:chemistry / Q000494:pharmacology; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology
D002264:Carboxylic Acids; D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D013892:Thioxanthenes; D014966:Xanthenes