The CULt of caspase-8 ubiquitination.
Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.
Békés
Miklós
M
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Salvesen
Guy S
GS
D017209:Apoptosis; D053181:Caspase 8 / Q000378:metabolism*; D044842:Cullin Proteins / Q000378:metabolism*; D053418:Death Domain Receptor Signaling Adaptor Proteins / Q000378:metabolism; D006801:Humans; D054875:Ubiquitination
C503645:CUL3 protein, human; D044842:Cullin Proteins; D053418:Death Domain Receptor Signaling Adaptor Proteins; D053181:Caspase 8