Efficacy of phthalocyanine tetrasulfonate against mouse-adapted human prion strains.
In vitro and in vivo studies have shown that phthalocyanine tetrasulfonate (PcTS), a cyclic tetrapyrrole compound, is an efficient antiscrapie drug. To investigate the spectrum of PcTS against prion diseases, we tested the effect of PcTS on two mouse-adapted human strains. We also tested PcTS in rodents infected with two scrapie strains (139A and 263K). PcTS treatment significantly prolonged mean survival times of all infected animals. These results show that PcTS is effective on different prion strains, confirming its potential use for prion therapy.
Abdel-Haq
Hanin
H
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy. hanin.abdelhaq@iss.it
Lu
Mei
M
Cardone
Franco
F
Liu
Quan Guo
QG
Puopolo
Maria
M
Pocchiari
Maurizio
M
D000818:Animals; D006224:Cricetinae; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use*; D008647:Mesocricetus; D051379:Mice; D008810:Mice, Inbred C57BL; D017096:Prion Diseases / Q000188:drug therapy*; D011328:Prions / Q000037:antagonists & inhibitors*; D016019:Survival Analysis
D004791:Enzyme Inhibitors; D007211:Indoles; D011328:Prions; C028418:tetrasulfophthalocyanine