First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy.
A qnrS1-positive strain of Escherichia coli was detected among 73 poultry isolates showing ciprofloxacin MICs of > or =0.125 microg/ml. The qnrS1 gene was associated with a Tn3-like transposon, as previously described to occur in a Salmonella enterica serovar Infantis strain of animal origin, but the plasmid scaffold carrying this element resembled that of a plasmid previously identified in Salmonella enterica serovar Dublin. These elements suggest genetic exchanges among Salmonella and E. coli and a potential animal reservoir for the qnr genes.
Cerquetti
Marina
M
Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
García-Fernández
Aurora
A
Giufrè
Maria
M
Fortini
Daniela
D
Accogli
Marisa
M
Graziani
Caterina
C
Luzzi
Ida
I
Caprioli
Alfredo
A
Carattoli
Alessandra
A
D000818:Animals; D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D005798:Genes, Bacterial / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics*; D011200:Poultry; D011201:Poultry Diseases / Q000382:microbiology*; D015363:Quinolones / Q000494:pharmacology*; D019779:Salmonella enterica / Q000235:genetics
D000900:Anti-Bacterial Agents; D015363:Quinolones; D002939:Ciprofloxacin