title: Total synthesis of atrochamins F, H, I, and J through cascade reactions.
abstract: A concise and efficient cascade-based total synthesis of artochamins F, H, I, and J is described. The potential biogenetic connection between artochamin F, or a derivative thereof, and artochamins H, I, and J, through an unusual formal [2+2] cycloaddition process, was shown to be feasible. An alternative mechanism for this transformation is also proposed.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla 92037, U.S.A.
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
authors.forename: Troy
authors.initials: T
authors.lastname: Lister
authors.forename: Ross M
authors.initials: RM
authors.lastname: Denton
authors.forename: Christine F
authors.initials: CF
authors.lastname: Gelin