title: EGF receptor as a drug target in arterial hypertension.
abstract: Drugs which inhibit epidermal growth factor receptor (EGFR) are used in the treatment of cancers. EGFR may contribute to the development of hypertension by regulating vascular tone and renal Na+ handling. Synthetic EGFR inhibitors reduce blood pressure in some experimental models of hypertension suggesting that this receptor is a novel target for antihypertensive therapy.
authors.affiliation: Department of Pathophysiology, Medical University, ul. Jaczewskiego 8, 20-090 Lublin, Poland. jerzy.beltowski@am.lublin.pl
authors.forename: J
authors.initials: J
authors.lastname: Bełtowski
authors.forename: E
authors.initials: E
authors.lastname: Lowicka
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001158:Arteries / Q000187:drug effects / Q000473:pathology*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D008024:Ligands; D015533:Transcriptional Activation / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D008024:Ligands; D066246:ErbB Receptors