title: Emerging PEGylated drugs.
abstract: PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect. Currently, PEGylation is used to modify proteins, peptides, oligonucleotides, antibody fragments, and small organic molecules. Research groups are striving to improve the consistencies of PEGylated drugs and to PEGylate commercialized proteins and small organic molecules. Furthermore, the PEGylations of novel medications, like oligonucleotides and antibody fragments, are being pursued to improve their bioavailabilities. This active research in the PEGylation field and the continued growth of the biopharmaceutical market predicts that PEGylated drugs have a bright future.
authors.affiliation: SungKyunKwan University, College of Pharmacy, Drug Targeting Laboratory, Suwon 440-746, Korea.
authors.forename: Jung Seok
authors.initials: JS
authors.lastname: Kang
authors.forename: Patrick P
authors.initials: PP
authors.lastname: Deluca
authors.forename: Kang Choon
authors.initials: KC
authors.lastname: Lee
mesh_terms: D004337:Drug Carriers / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D015507:Drugs, Investigational / Q000627:therapeutic use*; D006801:Humans; D007128:Immunoglobulin Fragments / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000627:therapeutic use*; D011506:Proteins / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D054852:Small Molecule Libraries / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D004337:Drug Carriers; D015507:Drugs, Investigational; D007128:Immunoglobulin Fragments; D010455:Peptides; D011506:Proteins; D054852:Small Molecule Libraries; D011092:Polyethylene Glycols