title: Initial experience with the radiotracer anti-1-amino-3-[18F]Fluorocyclobutane-1-carboxylic acid (anti-[ 18F]FACBC) with PET in renal carcinoma.
abstract: OBJECTIVE
  Assessment of renal masses with conventional imaging may be challenging. Anti-1-amino-3-[(18)F]fluorocyclobutane-1-carboxylic acid (anti-[18F]FACBC) is a synthetic L: -leucine analog with relatively little renal excretion. The present study examines anti-[(18)F]FACBC positron emission tomography uptake in patients with renal masses.
  
  
  METHODS
  Six patients with seven renal lesions were imaged dynamically for 2 h after injection of 10-10.9 mCi (370-403 MBq) anti-[(18)F]FACBC. Lesions were evaluated qualitatively and quantitatively and correlated with histology.
  
  
  RESULTS
  Four clear cell and one Rosai-Dorfman lesion were hypo/isointense to normal cortex; two papillary lesions in the same patient were hyperintense. Mean SUV(max) +/- SD at 30 min was 2.8 +/- 0.24 for clear cell carcinomas and 4.5 +/- 1.7 for papillary cell lesions. Mean SUV(max)/SUV(mean) ratios +/- SD of lesion to normal cortex at 30 min was 1.15 +/- 0.19 for the clear cell carcinomas and 2.3 +/- 0.84 for papillary cell.
  
  
  CONCLUSIONS
  In this small patient sample, relative amino acid transport compared with renal cortex is elevated in renal papillary cell carcinoma but not in clear cell carcinoma.
authors.affiliation: Department of Radiology, Division of Nuclear Medicine, Emory University, Atlanta, GA 30322, USA. dschust@emory.edu
authors.forename: David M
authors.initials: DM
authors.lastname: Schuster
authors.forename: Jonathon A
authors.initials: JA
authors.lastname: Nye
authors.forename: Peter T
authors.initials: PT
authors.lastname: Nieh
authors.forename: John R
authors.initials: JR
authors.lastname: Votaw
authors.forename: Raghuveer K
authors.initials: RK
authors.lastname: Halkar
authors.forename: Muta M
authors.initials: MM
authors.lastname: Issa
authors.forename: Weiping
authors.initials: W
authors.lastname: Yu
authors.forename: Julio
authors.initials: J
authors.lastname: Sepulveda
authors.forename: Wanzhen
authors.initials: W
authors.lastname: Zeng
authors.forename: Andrew
authors.initials: A
authors.lastname: Young
authors.forename: Mark M
authors.initials: MM
authors.lastname: Goodman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002264:Carboxylic Acids; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003503:Cyclobutanes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D019275:Radiopharmaceuticals
chemical_list: D002264:Carboxylic Acids; D003503:Cyclobutanes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C117460:fluciclovine F-18