Initial experience with the radiotracer anti-1-amino-3-[18F]Fluorocyclobutane-1-carboxylic acid (anti-[ 18F]FACBC) with PET in renal carcinoma.
OBJECTIVE
Assessment of renal masses with conventional imaging may be challenging. Anti-1-amino-3-[(18)F]fluorocyclobutane-1-carboxylic acid (anti-[18F]FACBC) is a synthetic L: -leucine analog with relatively little renal excretion. The present study examines anti-[(18)F]FACBC positron emission tomography uptake in patients with renal masses.


METHODS
Six patients with seven renal lesions were imaged dynamically for 2 h after injection of 10-10.9 mCi (370-403 MBq) anti-[(18)F]FACBC. Lesions were evaluated qualitatively and quantitatively and correlated with histology.


RESULTS
Four clear cell and one Rosai-Dorfman lesion were hypo/isointense to normal cortex; two papillary lesions in the same patient were hyperintense. Mean SUV(max) +/- SD at 30 min was 2.8 +/- 0.24 for clear cell carcinomas and 4.5 +/- 1.7 for papillary cell lesions. Mean SUV(max)/SUV(mean) ratios +/- SD of lesion to normal cortex at 30 min was 1.15 +/- 0.19 for the clear cell carcinomas and 2.3 +/- 0.84 for papillary cell.


CONCLUSIONS
In this small patient sample, relative amino acid transport compared with renal cortex is elevated in renal papillary cell carcinoma but not in clear cell carcinoma.
Schuster
David M
DM
Department of Radiology, Division of Nuclear Medicine, Emory University, Atlanta, GA 30322, USA. dschust@emory.edu
Nye
Jonathon A
JA
Nieh
Peter T
PT
Votaw
John R
JR
Halkar
Raghuveer K
RK
Issa
Muta M
MM
Yu
Weiping
W
Sepulveda
Julio
J
Zeng
Wanzhen
W
Young
Andrew
A
Goodman
Mark M
MM
D000368:Aged; D000369:Aged, 80 and over; D002264:Carboxylic Acids; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003503:Cyclobutanes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D019275:Radiopharmaceuticals
D002264:Carboxylic Acids; D003503:Cyclobutanes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C117460:fluciclovine F-18