Association between prehypertension and clustering of cardiovascular disease risk factors among Chinese adults.
OBJECTIVE
We aimed to estimate the association between prehypertension (PHT) and clustering of cardiovascular disease (CVD) risk factors among Chinese adults.


METHODS
A cross-sectional survey in a nationally representative sample of 15,540 Chinese adults aged 35-74 years was conducted during 2000-2001.


RESULTS
Overall, 79.4%, 40.0%, and 11.0% of Chinese adults with PHT (120-139/80-89 mm Hg) had >or=1, >or=2, and >or=3 modifiable CVD risk factors (dyslipidemia, impaired fasting glucose/diabetes, cigarette smoking, and overweight/obesity), respectively. The adjusted odds ratio (95% confidence interval, CI) of having >or=1, >or=2, and >or=3 CVD risk factors was 1.41 (1.24-1.61), 1.45 (1.30-1.61), and 1.96 (1.67-2.29), respectively, for adults with PHT compared with those with optimal blood pressure by multivariate models. Moreover, population attributable risk percent of having >or=1, >or=2, and >or=3 CVD risk factors was 16.7%, 18.0%, and 31.9%, respectively, for adults with PHT. Furthermore, among adults with PHT, higher prevalence, adjusted odds ratios, and population attributable risk percent of having >or=1, >or=2, and >or=3 CVD risk factors were more likely to be found among people with high normal blood pressure (130-139/85-89 mm Hg) compared with their counterparts with normal blood pressure (120-129/80-84 mm Hg).


CONCLUSIONS
Clustering of CVD risk factors is common among Chinese adults with PHT, especially with high normal blood pressure. Global lifestyle modification would be a very important nonpharmaceutical therapy to reduce the increasing burden of CVD in China.
Yu
Dahai
D
Department of Evidence-Based Medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Huang
Jianfeng
J
Hu
Dongsheng
D
Chen
Jichun
J
Cao
Jie
J
Li
Jianxin
J
Gu
Dongfeng
D
D000328:Adult; D000367:Age Factors; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D048909:Diabetes Complications; D050171:Dyslipidemias / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D011159:Population Surveillance; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects