Overexpression of the CXCL3 gene in response to oxidized low-density lipoprotein is associated with the presence of tendon xanthomas in familial hypercholesterolemia.
To examine if overexpression of certain chemokines and proinflammatory cytokines in response to oxidized low-density lipoprotein could be involved in the onset and development of tendon xanthomas (TX), we quantified IL-1beta, TNF-alpha, and IL-8 and compared gene expression of PPAR-gamma, NF-kappaBIA, IL-8, IL-1beta, CXCL3, tryptase, and TNF-alpha in macrophages of familial hypercholesterolemia subjects with and without TX stimulated with oxidized low-density lipoprotein at 1, 3, 6, and 18 h of incubation. We propose that chemokines belonging to the CXC family could play an important role in the etiology of TX, with CXCL3 being a possible biological marker of onset and development of TX.
Martín-Fuentes
Paula
P
Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud (I+CS), Zaragoza, Spain. pmartin.iacs@aragon.es
Civeira
Fernando
F
Solanas-Barca
María
M
García-Otín
Angel Luis
AL
Jarauta
Estíbaliz
E
Cenarro
Ana
A
D000328:Adult; D019743:Chemokines, CXC / Q000235:genetics*; D003240:Connective Tissue Diseases / Q000150:complications / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000235:genetics*; D008077:Lipoproteins, LDL / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013710:Tendons / Q000473:pathology*; D014973:Xanthomatosis / Q000150:complications / Q000235:genetics*
C499707:CXCL3 protein, human; D019743:Chemokines, CXC; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein