title: Biological variation in fasting serum insulin-like growth factor binding protein-1 (IGFBP-1) among individuals with a varying glucose tolerance.
abstract: OBJECTIVE
  To evaluate the biological variation of serum insulin-like growth factor binding protein-1 (IGFBP-1) in individuals with different degrees of glucose tolerance.
  
  
  METHODS
  IGFBP-1 was measured in 42 fasted subjects with: normal glucose tolerance (NGT=15), impaired fasting glucose (IFG=9), impaired glucose tolerance (IGT=9) and type 2 diabetics (DM=9). Short- and long-term reproducibility was determined for IGFBP-1.
  
  
  RESULTS
  The longer-term reproducibility (CV) of serum IGFBP-1 was 20.9%, 29.5%, 33.1% and 48.0% for subjects with NGT, IFG, IGT and DM respectively. The results for the short-term serum IGFBP-1 yielded CVs for these same respective categories of 8.2%, 16.1%, 29.2% and 13.8%.
  
  
  CONCLUSIONS
  IGFBP-1 measurement was least variable in NGT individuals over both long-term and short-term intervals and variability increased with deteriorating glucose tolerance. Due to its biological variation, IGFBP-1 serum level is more reliable in normal subjects than in individuals with type 2 diabetes.
authors.affiliation: University of Surrey, Guildford, UK. a.al-borai@surrey.ac.uk
authors.forename: Anwar
authors.initials: A
authors.lastname: Borai
authors.forename: Callum
authors.initials: C
authors.lastname: Livingstone
authors.forename: Shweta
authors.initials: S
authors.lastname: Mehta
authors.forename: Hawazen
authors.initials: H
authors.lastname: Zarif
authors.forename: Fatima
authors.initials: F
authors.lastname: Abdelaal
authors.forename: Gordon
authors.initials: G
authors.lastname: Ferns
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D005215:Fasting / Q000097:blood*; D018149:Glucose Intolerance / Q000097:blood*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D015203:Reproducibility of Results
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1