Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population.
Excessive immune response is believed to play a role in the development of severe acute respiratory syndrome (SARS). Inhomogeneous spread of SARS led one to think of an Asian genetic predisposition and contribution of human leukocyte antigen (HLA) to the disease susceptibility. However, past case-control studies showed inconsistent results. In Viet Nam, of 62 patients with SARS, 44 participated in the present study together with 103 individuals who had contact with SARS patients and 50 without contact history. HLA-DRB1*12 was more frequently shown in SARS patients than in controls (corrected p = 0.042). HLA-DRB1*1202, the predominant allele in the Vietnamese population showed the strongest association with SARS in a dominant model (corrected p = 0.0065 and 0.0052, depending on the controls to be compared). Our results and accumulated data on HLA in the Asian populations would help in the understanding of associations with emerging infectious diseases.
Keicho
Naoto
N
Department of Respiratory Diseases, Research Institute, Tokyo, Japan. nkeicho-tky@umin.ac.jp
Itoyama
Satoru
S
Kashiwase
Koichi
K
Phi
Nguyen Chi
NC
Long
Hoang Thuy
HT
Ha
Le Dang
LD
Ban
Vo Van
VV
Hoa
Bach Khanh
BK
Hang
Nguyen Thi Le
NT
Hijikata
Minako
M
Sakurada
Shinsaku
S
Satake
Masahiro
M
Tokunaga
Katsushi
K
Sasazuki
Takehiko
T
Quy
Tran
T
D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D011110:Polymorphism, Genetic; D045169:Severe Acute Respiratory Syndrome / Q000208:ethnology / Q000235:genetics*; D014744:Vietnam
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553514:HLA-DRB1*12:02 antigen