title: Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice.
abstract: The mechanism of the analgesic effect of nitrous oxide (N(2)O) has not been completely clarified. Although we have reported that the analgesic effect of N(2)O was significantly decreased in nociceptin-orphanin FQ (N/OFQ) receptor (NOP)-deficient mice, the effect of nociceptin receptor antagonists on N(2)O-induced analgesia has not been reported. In this investigation, we examined the effect of the NOP antagonist JTC-801 on N(2)O-induced analgesia in 129Sv mice by the writhing test and tail flick test, and demonstrated that the analgesic effect of N(2)O was suppressed by the intraperitoneal administration of JTC-801.
authors.affiliation: Department of Anesthesia, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Koyama
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Fukuda
mesh_terms: D019342:Acetic Acid; D000634:Aminoquinolines / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009292:Narcotic Antagonists; D009609:Nitrous Oxide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor
chemical_list: D000634:Aminoquinolines; D018685:Anesthetics, Inhalation; D001549:Benzamides; C433236:N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D009609:Nitrous Oxide; D019342:Acetic Acid; D000094942:Nociceptin Receptor; C000722287:Oprl1 protein, mouse