title: Skin-type adnexal tumor with trichoblastic germinative differentiation in the breast: a case report.
abstract: Adnexal tumors with follicular differentiation in the breast parenchyma are rarely encountered. The authors present a unique case arising in a 64-year-old woman, in whom they observed composite differentiation toward follicular germinative cells of the hair follicle with focal areas of outer root sheath differentiation and pilar-type keratinization. The histogenesis of this tumor is analyzed in light of the peculiar pathological, immunohistochemical, and molecular genetic findings.
authors.affiliation: Department of Pathology, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey.
authors.forename: Ozay
authors.initials: O
authors.lastname: Gököz
authors.forename: Loretta
authors.initials: L
authors.lastname: Presenti
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Gambacorta
authors.forename: Federica
authors.initials: F
authors.lastname: Zolfanelli
authors.forename: Rossella
authors.initials: R
authors.lastname: Tricarico
authors.forename: Roberto
authors.initials: R
authors.lastname: Nistri
authors.forename: Gianna
authors.initials: G
authors.lastname: Baroni
authors.forename: Simonetta
authors.initials: S
authors.lastname: Bianchi
authors.forename: Daniela
authors.initials: D
authors.lastname: Massi
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D005260:Female; D006201:Hair Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D018859:Hair Follicle / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D020125:Mutation, Missense; D018294:Neoplasms, Adnexal and Skin Appendage / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D051176:beta Catenin / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D051176:beta Catenin