Molecular motors and the Golgi complex: staying put and moving through.
The Golgi apparatus is a highly dynamic organelle through which nascent proteins released from the endoplasmic reticulum (ER) are trafficked. Proteins are post-translationally modified within the Golgi and subsequently packaged into carriers for transport to a variety of cellular destinations. This transit of proteins, as well as the maintenance of Golgi structure and position, is highly dependent upon the actin and microtubule cytoskeletons and their associated molecular motors. Here we review how motors contribute to the correct functioning of the Golgi in higher eukaryotes and discuss the secretory pathway as a model system for studying cooperation between motor proteins.
Brownhill
Kim
K
University of Manchester, Faculty of Life Sciences, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
Wood
Laura
L
Allan
Viki
V
D000199:Actins / Q000378:metabolism; D000818:Animals; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000378:metabolism*; D021381:Protein Transport
D000199:Actins; D020409:Molecular Motor Proteins