Synthesis of a novel biodegradable and electroactive polyphosphazene for biomedical application.
To prepare one electroactive and biodegradable biomaterial for biomedical application, a new synthetic strategy was developed to synthesize a novel electrically conductive biodegradable polyphosphazene polymer containing parent aniline pentamer (PAP) and glycine ethyl ester (GEE) as side chains by a nucleophilic substitution reaction. The electrical conductivity of the polymer is approximately 2 x 10(-5) S cm(-1) in the semiconducting region upon preliminarily protonic-doped experiment. The degradation and RSC96 Schwann cells experiments in vitro prove that the polymer is biodegradable and beneficial to the cell adhesion and proliferation. The as-synthesized polymer also shows good solubility in common organic solvent and good film-forming properties. This new type of polymer has potential applications as scaffolds for neuronal and cardiovascular tissue engineering or other biomedical devices that require electroactivity.
Zhang
Qing-Song
QS
Biomedical Materials and Engineering Research Center, Wuhan University of Technology, Wuhan 430070, People's Republic of China. zhangqingsong@whut.edu.cn
Yan
Yu-Hua
YH
Li
Shi-Pu
SP
Feng
Tao
T
D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D018929:Cell Culture Techniques / Q000379:methods; D049109:Cell Proliferation; D002478:Cells, Cultured; D004553:Electric Conductivity; D009943:Organophosphorus Compounds / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012583:Schwann Cells / Q000166:cytology* / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D009943:Organophosphorus Compounds; D011108:Polymers; C108974:poly(phosphazene)