title: Novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
abstract: A novel ABC transporter gene, vga(C), was identified on the 14,365-bp multiresistance plasmid pKKS825 in a porcine methicillin (meticillin)-resistant Staphylococcus aureus isolate of sequence type 398. The vga(C) gene encodes a 523-amino-acid protein which confers resistance not only to streptogramin A antibiotics but also to lincosamides and pleuromutilins. Plasmid pKKS825 also carries the resistance genes aadD, tet(L), and dfrK, which may enable the coselection of vga(C) under selective pressure by kanamycin/neomycin, tetracyclines, and trimethoprim.
authors.affiliation: Institute of Farm Animal Genetics, Friedrich-Loeffler-Institute (FLI), Höltystr. 10, 31535 Neustadt-Mariensee, Germany.
authors.forename: Kristina
authors.initials: K
authors.lastname: Kadlec
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwarz
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D004224:Diterpenes / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D007612:Kanamycin / Q000494:pharmacology; D055231:Lincosamides / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics; D008969:Molecular Sequence Data; D009355:Neomycin / Q000494:pharmacology; D010957:Plasmids / Q000235:genetics*; D011083:Polycyclic Compounds; D013203:Staphylococcal Infections / Q000382:microbiology*; D025364:Streptogramin A / Q000494:pharmacology; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D013754:Tetracyclines / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D000097567:Pleuromutilins
chemical_list: D018528:ATP-Binding Cassette Transporters; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004224:Diterpenes; D007612:Kanamycin; D055231:Lincosamides; D009355:Neomycin; D011083:Polycyclic Compounds; D025364:Streptogramin A; D013754:Tetracyclines; D014295:Trimethoprim; D000097567:Pleuromutilins; C075964:VgA protein, Staphylococcus aureus