Efficacy and safety of long-term mycophenolate sodium therapy in pemphigus vulgaris.
BACKGROUND
Pemphigus is a chronic immunobullous disease, characterized by formation of blisters and erosions in skin and/or mucous membranes. This severe disease requires systemic immunosuppressive therapy. However, some patients are refractory, and long-term use of immunosuppressive agents can cause serious side-effects. Mycophenolic acid is increasingly being used as a corticosteroid-sparing agent or as monotherapy in immunosuppressive regimens.


OBJECTIVE
We aimed to evaluate the effectiveness of mycophenolate sodium, a sodium salt of mycophenolic acid, in the treatment of pemphigus vulgaris.


METHODS
Six patients who were diagnosed as pemphigus vulgaris with active, refractory disease were treated with mycophenolate sodium. Three patients received mycophenolate sodium monotherapy; three patients received mycophenolate in combination with steroid. All patients were monitored regularly.


RESULTS
Mycophenolate sodium was well tolerated with a similar efficacy of mycophenolate mofetil, and no side-effects have been observed.


CONCLUSIONS
Mycophenolate sodium appears to be an effective and safe alternative in the treatment of pemphigus vulgaris.
Baskan
E Bulbul
EB
Dermatology Department, Medical Faculty, Uludag University, Bursa, Turkey.
Yilmaz
M
M
Tunali
S
S
Saricaoglu
H
H
D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D010392:Pemphigus / Q000188:drug therapy*
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid