Netting neutrophils   in autoimmune   small-vessel vasculitis.
Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.
Kessenbrock
Kai
K
Department of Neuroimmunology,Max-Planck-Institute of Neurobiology, Martinsried, Germany. kai.kessenbrock@ucsf.edu
Krumbholz
Markus
M
Schönermarck
Ulf
U
Back
Walter
W
Gross
Wolfgang L
WL
Werb
Zena
Z
Gröne
Hermann-Josef
HJ
Brinkmann
Volker
V
Jenne
Dieter E
DE
D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D008833:Microcirculation / Q000276:immunology*; D053146:Myeloblastin / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology*
D001324:Autoantigens; D053146:Myeloblastin