title: [Preparation, identification and thermodynamic stability of capsaicin-hydroxypropyl-beta-cyclodextrin inclusion compound].
abstract: OBJECTIVE
  To prepare and identify the capsaicin-hydroxypropyl-beta-cyclodextrin (capsaicin-HP-beta-CD) inclusion compound the mol ratio between capsaicin and HP-beta-CD and the thermodynamic constants in inclusion were studied simultaneously.
  
  
  METHODS
  The capsaicin-HP-beta-CD inclusion compound was prepared with the method of saturation aqueous solution. Meanwhile, the inclusion compound was identified by differential scanning calorimetry methods (DSC), infrared spectrometry (IR), and X-ray diffraction (XRD), respectively. The mol ratio between host and guest molecular and the thermodynamic constants during the inclusion process were also researched by phase solubility method.
  
  
  RESULTS
  An 1 : 1 molar ratio inclusion compound of capsaicin with HP-beta-CD could form at 25, 35 and 45 degrees C. The phase diagram was A(L) type.
  
  
  CONCLUSIONS
  The solubility of capsaicin-HP-beta-CD inclusion compound can be increased obviously.
authors.affiliation: Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Chen
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Ren
authors.forename: Tao
authors.initials: T
authors.lastname: Gong
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002152:Calorimetry, Differential Scanning; D002211:Capsaicin / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D012995:Solubility; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods*; D013816:Thermodynamics; D014961:X-Ray Diffraction; D014965:X-Rays; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002211:Capsaicin