title: Dexamethasone decreases the transmesothelial electrical resistance of the parietal and visceral pleura.
abstract: The effect of dexamethasone on the transmesothelial electrical resistance (R(TM)) of sheep pleura was investigated by Ussing chamber experiments. Our results show that dexamethasone decreases the R(TM) of sheep pleurae, in part by stimulation of glucocorticoid receptors. This finding may be of importance in regard to the faster resolution of corticosteroid-treated pleural effusions.
authors.affiliation: Department of Physiology, University of Thessaly Medical School, Mezourlo Hill, 41110 Larissa, Greece.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Zarogiannis
authors.forename: Triantafyllia
authors.initials: T
authors.lastname: Deligiorgi
authors.forename: Ioannis
authors.initials: I
authors.lastname: Stefanidis
authors.forename: Vassilios
authors.initials: V
authors.lastname: Liakopoulos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Gourgoulianis
authors.forename: Paschalis Adam
authors.initials: PA
authors.lastname: Molyvdas
authors.forename: Chrissi
authors.initials: C
authors.lastname: Hatzoglou
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D017097:Electric Impedance; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010994:Pleura / Q000187:drug effects* / Q000502:physiology*; D010996:Pleural Effusion / Q000188:drug therapy; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000502:physiology; D012756:Sheep
chemical_list: D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone