title: Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm.
abstract: Fluorescently tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm.
authors.affiliation: Center for Biofilm Engineering, Department of Chemical and Biological Engineering, Montana State University, Bozeman, MT 59717-3980, USA. phil_s@biofilm.montana.edu
authors.forename: Philip S
authors.initials: PS
authors.lastname: Stewart
authors.forename: William M
authors.initials: WM
authors.lastname: Davison
authors.forename: Judith N
authors.initials: JN
authors.lastname: Steenbergen
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D018441:Biofilms / Q000187:drug effects; D017576:Daptomycin / Q000493:pharmacokinetics*; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin