[Urinary levels of B-type natriuretic peptide (BNP) and ventricular systolic dysfunction in heart failure patients].
BACKGROUND
It was aimed to compare urine B-type natriuretic peptide (BNP) according to left ventricular systolic dysfunction and to investigate its diagnostic value in heart failure (HF) patients.


METHODS
A total of 90 HF outpatients (61 men, age 66 +/- 12) and 30 age- and gender-matched controls were studied.


RESULTS
An increase in urine BNP was observed in patients with EF</= 40% compared to EF> 40% (p < 0.0001), and controls (p < 0.0001). Significant correlations between urinary BNP and left ventricular functional parameters were obtained. A multivariate regression analysis was performed and the best model associated with urine BNP included plasma BNP (p < 0.0001), EF (p = 0.02) and LV volume indexes (p < 0.0001). The ROC for detection of EF </= 40% using urine BNP levels showed an area under the curve of 0.74 +/- 0.05, (p < 0.0001). From the ROC curve, the optimal cut-off value (2.30 ng/l) had a 60% sensitivity and 90% specificity. Finally, we performed a binary logistic regression for detection of EF </= 40%, and urine BNP was shown to be a strong predictor with an odds-ratio of 21.


CONCLUSIONS
Urine BNP levels correlated with left ventricular functional parameters. This biomarker is a useful tool for detecting and diagnosing left ventricular systolic dysfunction in heart failure.
Cortés
R
R
Unidad de Cardiocirculación. Centro de Investigación. Hospital Universitario La Fe. Valencia. España.
Rivera
M
M
Martínez Dolz
L
L
Roselló-Lletí
E
E
Sancho-Tello
M J
MJ
Sevilla
B
B
Portolés
M
M
Cosín
J
J
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006333:Heart Failure / Q000150:complications* / Q000652:urine*; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000652:urine*; D011446:Prospective Studies; D018754:Ventricular Dysfunction / Q000150:complications*
D020097:Natriuretic Peptide, Brain