title: High-speed spectral-domain optical coherence tomography at 1.3 mum wavelength.
abstract: We demonstrate a high-speed spectral domain optical coherence tomography (SD-OCT) system capable of acquiring individual axial scans in 24.4 micros at a rate of 19,000 axial scans per second, using an InGaAs line scan camera and broadband light source centered at 1.31microm. Sensitivity of >105 dB over a 2-mm depth range was obtained with a free-space axial resolution of 12-14 microm, in agreement with our signal-to-noise ratio predictions. Images of human tissue obtained in vivo with SD-OCT show similar penetration depths to those obtained with state-of-the-art time domain OCT despite the ten-fold higher image acquisition speed. These results demonstrate the potential of 1.3 microm SD-OCT for high-speed and high-sensitivity imaging in patients.
authors.forename: S
authors.initials: S
authors.lastname: Yun
authors.forename: G
authors.initials: G
authors.lastname: Tearney
authors.forename: B
authors.initials: B
authors.lastname: Bouma
authors.forename: B
authors.initials: B
authors.lastname: Park
authors.forename: Johannes
authors.initials: J
authors.lastname: de Boer