title: [Case of optic neuritis associated with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)].
abstract: OBJECTIVE
  To report a case of optic neuritis associated with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).
  
  
  METHODS
  A 38-year-old woman presented with visual field defects, ocular pain and relative afferent papillary defect (RAPD). Fluorescein angiography demonstrated peripapillary hyperfluorescence of the optic nerve. Optic neuritis was diagnosed soon after. Routine laboratory data were unremarkable. Brain MRI showed a remarkable enhanced region of white matter and abnormal spots in the capsula externa. Multiple sclerosis was outruled by neurological findings and therefore CARASIL was diagnosed according to the criteria. The patient's vision and inflammation of the optic nerve head gradually improved with systemic steroid therapy, but arterial sheathing was observed during the follow-up period.
  
  
  CONCLUSIONS
  Clinical manifestations such as optic neuritis and retinal vascular change might be caused by the pathological changes of CARASIL. This is the first report of ophthalmic findings of clinicopathological events of CARASIL.
authors.affiliation: Department of Ophthalmology, Osaka University Medical School, Yamadaoka, Japan. nhashida@opthal.med.osaka-u.ac.jp
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Hashida
authors.forename: Shigeo
authors.initials: S
authors.lastname: Ito
authors.forename: Toshihide
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Teppei
authors.initials: T
authors.lastname: Kajita
authors.forename: Hiroko
authors.initials: H
authors.lastname: Morifuji
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Sakagami
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yokotani
authors.forename: Takehiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Bunji
authors.initials: B
authors.lastname: Endoh
authors.forename: Naohiro
authors.initials: N
authors.lastname: Egawa
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Inoue
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tomimoto
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D002544:Cerebral Infarction / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D015140:Dementia, Vascular / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D009902:Optic Neuritis / Q000209:etiology*; D031300:Retinal Vasculitis / Q000209:etiology; D013577:Syndrome