title: A Rh(II)-catalyzed cycloaddition approach towards the synthesis of komaroviquinone.
abstract: Using a rhodium(II)-catalyzed cyclization/cycloaddition sequence as the key reaction step, the icetexane core of komaroviquinone was constructed by an intramolecular dipolar-cycloaddition of a carbonyl ylide dipole across a tethered pi-bond. The ylide was arrived at by cyclization of a rhodium carbenoid intermediate onto a proximal ester group. Efforts towards the preparation of the required precursor for elaboration to the natural product are discussed.
authors.affiliation: Department of Chemistry, Emory University, Atlanta GA 30322, USA.
authors.forename: Albert
authors.initials: A
authors.lastname: Padwa
authors.forename: Majid J
authors.initials: MJ
authors.lastname: Chughtai
authors.forename: Jutatip
authors.initials: J
authors.lastname: Boonsombat
authors.forename: Paitoon
authors.initials: P
authors.lastname: Rashatasakhon