title: Low-frequency transcranial magnetic stimulation in patients with fibromyalgia and major depression.
abstract: OBJECTIVE
  To study the efficacy of low-frequency transcranial magnetic stimulation in patients with fibromyalgia and major depression.
  
  
  METHODS
  Twenty-eight patients were randomly assigned to receive 20 sessions of real or sham transcranial magnetic stimulation of the right dorsolateral prefrontal cortex. The main stimulation parameters were 15 trains at 110% of the motor threshold for 60 seconds at a frequency of 1 Hz. Blinded external evaluators administered the fibromyalgia scales (FibroFatigue, Likert pain) and the depression scales (Hamilton Depression Rating Scale, Clinical Global Impression) during the study.
  
  
  RESULTS
  Both treatment groups (real and sham) improved their scores in some of the scales (FibroFatigue and Clinical Global Impression), although there were no differences between them. No improvements were observed in the Likert Pain Scale in either of the groups.
  
  
  CONCLUSIONS
  With the methodology used in this study, patients with fibromyalgia and major depression who received real magnetic stimulation did not present significant differences in symptoms with respect to those who received sham magnetic stimulation.
authors.affiliation: Hospital Son Llatzer, Palma de Mallorca, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Carretero
authors.forename: Ma José
authors.initials: MJ
authors.lastname: Martín
authors.forename: Antonio
authors.initials: A
authors.lastname: Juan
authors.forename: Ma Luz
authors.initials: ML
authors.lastname: Pradana
authors.forename: Beatriz
authors.initials: B
authors.lastname: Martín
authors.forename: Maria
authors.initials: M
authors.lastname: Carral
authors.forename: Teresa
authors.initials: T
authors.lastname: Jimeno
authors.forename: Antonio
authors.initials: A
authors.lastname: Pareja
authors.forename: Pedro
authors.initials: P
authors.lastname: Montoya
authors.forename: Iratxe
authors.initials: I
authors.lastname: Aguirre
authors.forename: Joan
authors.initials: J
authors.lastname: Salva
authors.forename: Miguel
authors.initials: M
authors.lastname: Roca
authors.forename: Margalida
authors.initials: M
authors.lastname: Gili
authors.forename: Mauro
authors.initials: M
authors.lastname: Garcia-Toro
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D005260:Female; D005356:Fibromyalgia / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology*; D016037:Single-Blind Method; D050781:Transcranial Magnetic Stimulation / Q000379:methods* / Q000706:statistics & numerical data; D017211:Treatment Failure