title: Increased baroreflex sensitivity and heart rate variability in migraine patients.
abstract: OBJECTIVE
  We investigated whether spontaneous baroreflex sensitivity and heart rate variability (HRV) are different in migraine patients compared to healthy controls.
  
  
  METHODS
  Sixteen female migraine patients without aura aged 18-30 years and 14 age-matched healthy female controls were included. Continuous finger blood pressure and ECG were measured supine during paced breathing in the laboratory. Continuous finger blood pressure was measured the following 24-h period. Spontaneous baroreflex sensitivity (time-domain cross correlation baroreflex sensitivity) as well as HRV parameters were calculated.
  
  
  RESULTS
  Spontaneous baroreflex sensitivity measured in the 24-h period was increased in patients (20.6 ms/mmHg) compared to controls (15.7 ms/mmHg, P = 0.031). HRV parameters were increased during paced breathing in patients (P < 0.045).
  
  
  CONCLUSIONS
  The results suggest that central hypersensitivity in migraine also includes cardiovascular reactivity and may be important for the understanding of the mechanisms for the effect of antihypertensive drugs for migraine prophylaxis.
authors.affiliation: Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, MTFS, 7489 Trondheim, Norway. kristian.b.nilsen@ntnu.no
authors.forename: K B
authors.initials: KB
authors.lastname: Nilsen
authors.forename: E
authors.initials: E
authors.lastname: Tronvik
authors.forename: T
authors.initials: T
authors.lastname: Sand
authors.forename: G B
authors.initials: GB
authors.lastname: Gravdahl
authors.forename: L J
authors.initials: LJ
authors.lastname: Stovner
mesh_terms: D000293:Adolescent; D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D020326:Migraine without Aura / Q000503:physiopathology*; D012119:Respiration; D015656:Respiratory Mechanics; D016683:Supine Position