title: Liquid ecstasy - a significant drug problem.
abstract: BACKGROUND
  Gamma-hydroxybutyric acid (GHB, "liquid ecstasy") and its legal pro-drugs gamma-butyrolactone and 1,4-butanediol are gaining in importance as recreational drugs in Germany. The effects of these substances are comparable with those of alcohol or benzodiazepines. Because of the wide availability of GHB physicians are increasingly being confronted with cases of intoxication.
  
  
  METHODS
  This review is based on a selective literature search as well as on the authors' own experience and on information provided by the GIZ-Nord Poisons Centre, Göttingen, Germany.
  
  
  RESULTS
  Consumption of a high dose of GHB or its prodrugs leads to severe intoxication with respiratory depression and coma. Only supportive therapy can be offered; no antidote is available.
  
  
  CONCLUSIONS
  In any patient with impaired consciousness of unknown cause, the possibility of intoxication with GHB must be considered. Chemical detection of GHB in blood or urine is possible only using specific analytical methods and only within a short time frame (<12 h). Because of the short half-life of GHB, intoxications treated in intensive care units rarely show any complications. However, a number of fatalities have occurred. The potential abuse of GHB as a date rape drug must be borne in mind.
authors.forename: Hilke
authors.initials: H
authors.lastname: Andresen
authors.forename: Thomas
authors.initials: T
authors.lastname: Stimpfl
authors.forename: Nadine
authors.initials: N
authors.lastname: Sprys
authors.forename: Tino
authors.initials: T
authors.lastname: Schnitgerhans
authors.forename: Alexander
authors.initials: A
authors.lastname: Müller