title: [Evolution and mutation of human Y chromosome and their relationship with male infertility].
abstract: The Y chromosome evolves from euchromosome and accumulates a variety of male-specific genes, including SRY and many others that are related with spermatogenesis. The Y chromosome is distinguished from euchromosome by its characteristics of multiple copies of gene, multiple DNA sequences and high polymorphism. A lot of gene rearrangements occur during its evolution due to the specific gene structure in the Y chromosome. It has been discovered that one subset of such gene rearrangements induces Y-chromosome microdeletions that are involved in male infertility. Spermatogenesis is actually controlled by a network of genes, which may be located on the Y chromosome, euchromosomes or even the X chromosome. Further studies on the genomics and genes in the Y chromosome between sex chromosomes and/or between sex chromosome and euchromosomes will helps us to gain deeper insights into the molecular mechanism of male infertility.
authors.affiliation: Department of Urology, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China. lizhengboshi@163.com
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Xiang-Feng
authors.initials: XF
authors.lastname: Chen
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Sha
mesh_terms: D041322:Chromosomes, Human, Y; D019143:Evolution, Molecular; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009154:Mutation