The angiosperm gibberellin-GID1-DELLA growth regulatory mechanism: how an "inhibitor of an inhibitor" enables flexible response to fluctuating environments.
The phytohormone gibberellin (GA) has long been known to regulate the growth, development, and life cycle progression of flowering plants. However, the molecular GA-GID1-DELLA mechanism that enables plants to respond to GA has only recently been discovered. In addition, studies published in the last few years have highlighted previously unsuspected roles for the GA-GID1-DELLA mechanism in regulating growth response to environmental variables. Here, we review these advances within a general plant biology context and speculate on the answers to some remaining questions. We also discuss the hypothesis that the GA-GID1-DELLA mechanism enables flowering plants to maintain transient growth arrest, giving them the flexibility to survive periods of adversity.
Harberd
Nicholas P
NP
Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom. nicholas.harberd@plants.ox.ac.uk
Belfield
Eric
E
Yasumura
Yuki
Y
D000222:Adaptation, Physiological; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005875:Gibberellins / Q000502:physiology*; D008954:Models, Biological; D010937:Plant Growth Regulators / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D029681:Arabidopsis Proteins; C109555:GAI protein, Arabidopsis; C512225:GID1a protein, Arabidopsis; D005875:Gibberellins; D010937:Plant Growth Regulators; D011956:Receptors, Cell Surface; D046988:Proteasome Endopeptidase Complex