title: Concurrent decline of several antioxidants and markers of oxidative stress during combination chemotherapy for small cell lung cancer.
abstract: OBJECTIVE
  To investigate the oxidant effects of adriamycin-containing chemotherapy (CT), we evaluated various antioxidants, total antioxidant capacity (TRAP) and different parameters of oxidative and nitrosative stress during combination CT.
  
  
  METHODS
  Blood samples were obtained from 16 small cell lung cancer patients at baseline and several times during the first, second and sixth CT cycles.
  
  
  RESULTS
  There were significant decreases in serum urate and serum proteins during all cycles, serum TRAP during the first two cycles, plasma ascorbic acid and serum TBARS during the first cycle, and serum conjugated dienes and plasma alphatocopherol during the last cycle. The baseline levels of tocopherols increased significantly between the first and sixth CT cycles. Higher levels of baseline plasma thiols were associated with better overall survival (p=0.008).
  
  
  CONCLUSIONS
  Adriamycin-containing CT causes significant oxidative stress as implied by reduced levels of protective antioxidants. Long-term CT treatment seems to enhance lipid peroxidation.
authors.affiliation: Department of Oncology, University of Tampere, Finland. macro1@sci.fi
authors.forename: Marika
authors.initials: M
authors.lastname: Crohns
authors.forename: Kari
authors.initials: K
authors.lastname: Liippo
authors.forename: Marina
authors.initials: M
authors.lastname: Erhola
authors.forename: Hannu
authors.initials: H
authors.lastname: Kankaanranta
authors.forename: Eeva
authors.initials: E
authors.lastname: Moilanen
authors.forename: Hannu
authors.initials: H
authors.lastname: Alho
authors.forename: Pirkko
authors.initials: P
authors.lastname: Kellokumpu-Lehtinen
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D055752:Small Cell Lung Carcinoma / Q000097:blood / Q000188:drug therapy; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D017392:Thiobarbituric Acid Reactive Substances