title: [A case of double advanced cancer with esophageal and hypopharyngeal carcinoma responding completely to combination chemotherapy of docetaxel/5-fluorouracil and nedaplatin with radiation].
abstract: A 69-year-old male was admitted to our hospital because of dysphagia. The diagnosis was double cancer with hypopharyngeal and esophageal carcinoma from upper gastrointestinal endoscopic examination. Pathological examinations of the double cancer revealed moderately-differentiated squamous cell carcinoma. Computed tomography(CT)of the neck and abdomen showed metastases of the right neck and cardiac lymph nodes. Clinical stagings of the double cancer were Stage III (T1, N1, M0)in hypopharyngeal carcinoma and Stage III (T3, N1, M0)in esophageal carcinoma, respectively. He received radiation therapy in combination with chemotherapy using docetaxel(DOC), 5-fluorouracil (5-FU)and nedaplatin(CDGP). After this combination chemoradiation therapy(CRT), the adverse event was grade 2 in leucopenia and grade 2 in gastrointestinal toxicity. Repeated macroscopic and histological examinations after CRT revealed disappearance of the hypopharyngeal and advanced esophageal carcinoma with lymph node metastasis, leading to a complete response(CR). He had maintained CR for the 20 months since undergoing CRT. This combination chemotherapy of DOC, 5-FU and CDGP with radiation may well be effective and tolerable for patients with double cancer of hypopharyngeal and esophageal carcinoma.
authors.affiliation: Dept. of Surgery, Nippon Medical School Tama-Nagayama Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsutani
authors.forename: Koji
authors.initials: K
authors.lastname: Sasajima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Seiji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Masayuki
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sugiura
authors.forename: Akira
authors.initials: A
authors.lastname: Matsushita
authors.forename: Ken
authors.initials: K
authors.lastname: Yanagi
authors.forename: Akihisa
authors.initials: A
authors.lastname: Matsuda
authors.forename: Hiroki
authors.initials: H
authors.lastname: Arai
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Nishi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Wakabayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Tajiri
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D004945:Esophagoscopy; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012074:Remission Induction; D043823:Taxoids / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D009944:Organoplatinum Compounds; D043823:Taxoids; D000077143:Docetaxel; C053989:nedaplatin; D005472:Fluorouracil