Bile acid-based polyaminocarboxylate conjugates as targeted antitumor agents.
Bile acid-polyaminocarboxylate conjugates containing NE3TA, a potential iron chelator displayed significant cytotoxicities in both HeLa and HT29 colon cancer cells, and cholic acid-NE3TA attached to an organic fluorophore was shown to enter the HT29 cancer cells.
Chong
Hyun-Soon
HS
Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, IL, USA. chong@iit.edu
Song
Hyun A
HA
Ma
Xiang
X
Lim
Sooyoun
S
Sun
Xiang
X
Mhaske
Santosh B
SB
D000588:Amines / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry*; D001647:Bile Acids and Salts / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence
D000588:Amines; D000970:Antineoplastic Agents; D001647:Bile Acids and Salts; D002264:Carboxylic Acids