Peptide trafficking and translocation across membranes in cellular signaling and self-defense strategies.
Cells are metastable per se and a fine-tuned balance of de novo protein synthesis and degradation shapes their proteome. The primary function of peptides is to supply amino acids for de novo protein synthesis or as an energy source during starvation. Peptides are intrinsically short-lived and steadily trimmed by an armada of intra and extracellular peptidases. However, peptides acquired additional, more sophisticated tasks already early in evolution. Here, we summarize current knowledge on intracellular peptide trafficking and translocation mediated by ATP-binding cassette (ABC) transport machineries with a focus on the functions of protein degradation products as important signaling molecules in self-defense mechanisms.
Abele
Rupert
R
Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt aM, Germany.
Tampé
Robert
R
D000255:Adenosine Triphosphate / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D002453:Cell Cycle; D002462:Cell Membrane / Q000378:metabolism*; D003713:Dendritic Cells / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000737:chemistry; D006801:Humans; D008247:Lysosomes / Q000737:chemistry; D008954:Models, Biological; D010455:Peptides / Q000737:chemistry*; D021381:Protein Transport; D040901:Proteomics / Q000379:methods; D015398:Signal Transduction; D014764:Viral Proteins / Q000737:chemistry; D014780:Viruses / Q000378:metabolism
D000596:Amino Acids; D015395:Histocompatibility Antigens Class I; D010455:Peptides; D014764:Viral Proteins; D000255:Adenosine Triphosphate