title: Characteristics and outcome of prostate cancer with PSA <4 ng/ml at diagnosis: a population-based study.
abstract: This population-based study aims to assess prognosis of prostate cancer diagnosed with prostate-specific antigen (PSA) levels <4 ng/ml in routine care. Materials and methods We compared prostate cancer patients with low PSA values (n=59) with other prostate cancer patients (n=1330) by logistic regression and the Cox model using data from the Geneva Cancer Registry. Results Patients with low PSA values more frequently had early-stage and well differentiated tumours. Nevertheless, 35% presented with aggressive tumour characteristics or metastases. After adjustment for other prognostic factors, prostate cancer-specific mortality was similar for both groups (hazard ratio: 1.1; 95%CI: 0.6-2.2). Conclusion We conclude that cancer with low PSA values at diagnosis is not indolent.
authors.affiliation: Division of Radiation Oncology, Geneva University Hospitals, Geneva, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Bonet
authors.forename: A
authors.initials: A
authors.lastname: Merglen
authors.forename: G
authors.initials: G
authors.lastname: Fioretta
authors.forename: E
authors.initials: E
authors.lastname: Rapiti
authors.forename: I
authors.initials: I
authors.lastname: Neyroud-Caspar
authors.forename: R
authors.initials: R
authors.lastname: Zanetti
authors.forename: R
authors.initials: R
authors.lastname: Miralbell
authors.forename: C
authors.initials: C
authors.lastname: Bouchardy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D016019:Survival Analysis
chemical_list: D017430:Prostate-Specific Antigen