A new seco-friedelolactone acid from the bark and twigs of Itoa orientalis.
A new seco-friedelolactone, named itoaic acid, together with 5 known compounds was isolated from the bark and twigs of Itoa orientalis. The structure was elucidated by means of MS, 1D and 2D NMR techniques. Anti-inflammatory activity against COX-2 was evaluated for several compounds from I. orientalis and another Flacourtiaceae plant Xylosma controversum.
Chai
Xing-Yun
XY
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
Xu
Zheng-Ren
ZR
Bai
Chang-Cai
CC
Zhou
Fei-Ran
FR
Tu
Peng-Fei
PF
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051546:Cyclooxygenase 2 / Q000378:metabolism; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018547:Plant Stems; D031308:Salicaceae / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; C544790:itoaic acid; D009828:Oleanolic Acid; D051546:Cyclooxygenase 2