title: Dairy and industrial sources of trans fat do not impair peripheral insulin sensitivity in overweight women.
abstract: BACKGROUND
  The 2 major dietary sources of trans fatty acids (TFAs) are partially hydrogenated oils and ruminant-derived products. Epidemiologic data suggest that chronic consumption of industrial sources of TFAs could be damaging to insulin sensitivity, but intervention studies on this issue have remained inconclusive.
  
  
  OBJECTIVE
  The trial was designed to compare the effects of dairy compared with industrial sources of TFAs on insulin sensitivity in overweight women.
  
  
  METHODS
  Sixty-three healthy women with abdominal obesity [waist circumference >88 cm and a body mass index (in kg/m(2)) >28] were recruited. After a run-in period, the volunteers were randomly assigned to consume 1 of 3 four-week diets: 60 g low-TFA lipids/d (0.54 g/d; n = 21), ruminant TFA-rich lipids (4.86 g/d; n = 21), or industrial TFA-rich lipids (5.58 g/d; n = 21). Changes in peripheral insulin sensitivity were assessed by using hyperinsulinemic-euglycemic clamps.
  
  
  RESULTS
  After the intervention period, fasting glycemia and insulinemia and insulin sensitivity were not significantly modified in either group (P > 0.05).
  
  
  CONCLUSIONS
  These data indicate that consumption of dairy- and industrial-source TFAs for 4 wk at nutritional levels do not impair peripheral insulin sensitivity in insulin-resistant women. Our study may not preassess the effects of TFAs in normal insulin-sensitive individuals. This trial was registered at ClinicalTrials.gov as NCT00617435.
authors.affiliation: From INRA, UMR 1019 Nutrition Humaine, Saint Genès Champanelle, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Tardy
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Lambert-Porcheron
authors.forename: Corinne
authors.initials: C
authors.lastname: Malpuech-Brugère
authors.forename: Christophe
authors.initials: C
authors.lastname: Giraudet
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Rigaudière
authors.forename: Brigitte
authors.initials: B
authors.lastname: Laillet
authors.forename: Pascale
authors.initials: P
authors.lastname: Leruyet
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Peyraud
authors.forename: Yves
authors.initials: Y
authors.lastname: Boirie
authors.forename: Martine
authors.initials: M
authors.lastname: Laville
authors.forename: Marie-Caroline
authors.initials: MC
authors.lastname: Michalski
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Chardigny
authors.forename: Béatrice
authors.initials: B
authors.lastname: Morio
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D003611:Dairy Products; D004041:Dietary Fats / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D006946:Hyperinsulinism; D007328:Insulin / Q000494:pharmacology*; D007333:Insulin Resistance / Q000502:physiology*; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000503:physiopathology*; D010349:Patient Compliance; D010743:Phospholipids / Q000097:blood; D012418:Ruminants; D044242:Trans Fatty Acids / Q000494:pharmacology*; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D010743:Phospholipids; D044242:Trans Fatty Acids