Irritable bowel syndrome is more frequent in patients hospitalized for ischaemic colitis: results of a case-control study.
It has been suspected that there is an epidemiological link between irritable bowel syndrome (IBS) and ischaemic colitis (IC). We performed a retrospective case-control study to compare the frequency of IBS in patients hospitalized for IC compared with that of patients with peptic ulcer bleeding. Cases were patients with a first episode of IC and controls were patients with a first episode of peptic ulcer bleeding, matched to cases for sex and 10-year age-class. Diagnosis of IBS was based on medical information extracted from hospital medical files and a standard self-questionnaire. The association between IBS and IC was tested using Mc Nemar's paired odds ratio (OR); confidence interval at 95% (CI 95%) was calculated; Mantel-Haenzel's Chi(2) was applied. A total of 113 cases and 113 matched controls were studied. There were 37 males and 76 females and the mean age was 69 +/- 15 years in each group. The prevalence of IBS in cases was 16.9%vs 1.8% in controls. The risk of IBS was 11.05 times higher among cases than in controls (P < 0.001); CI 95%: (2.45-49.74). A total of 87 pairs with complete data were used for OR calculation. The risk of IBS was 7.5 times higher in cases than in controls (P = 0.002); CI 95%: (1.72-32.80). This case-control study shows that IBS is more frequent in IC patients than in controls.
Hervé
S
S
Département d'hépatogastroentérologie, Rouen University Hospital, Rouen, France. sophie.herve@chu-rouen.fr
Beaugerie
L
L
Bouhnik
Y
Y
Savoye
G
G
Colombel
J-F
JF
Dyard
F
F
Hourmand-Ollivier
I
I
Dao
T
T
Vial
M
M
Lerebours
E
E
D000368:Aged; D016022:Case-Control Studies; D017091:Colitis, Ischemic / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D011795:Surveys and Questionnaires