title: Association study of the serotoninergic system in migraine in the Spanish population.
abstract: In order to evaluate the contribution of 19 serotonin-related genes to the susceptibility to migraine in a Spanish population we performed a case-control association study of 122 single nucleotide polymorphisms (SNPs), selected according to genetic coverage parameters, in 528 migraine patients -308 with migraine without aura (MO) and 220 with migraine with aura (MA)- and 528 sex-matched migraine-free controls. The single-marker analysis identified nominal associations with the migraine phenotype or with the MO or MA subtypes. The multiple-marker analysis revealed risk haplotypes in three genes that remained significantly associated with migraine after correction by permutations. Two-marker risk haplotypes were identified in the HTR2B (rs16827801T-rs10194776G) and MAOA (rs3027400G-rs2072743C) genes conferring susceptibility to MO, and a four-marker haplotype in DDC was specific of MA (rs2329340A-rs11974297C-rs2044859T-rs11761683G). The present study supports the involvement of HTR2B and MAOA genes in the genetic predisposition to MO, while DDC might confer susceptibility to MA. These results suggest a differential involvement of serotonin-related genes in the genetic background of MO and MA.
authors.affiliation: Grup de Recerca en Neurologia Infantil i Psiquiatria Genètica, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Corominas
authors.forename: M J
authors.initials: MJ
authors.lastname: Sobrido
authors.forename: M
authors.initials: M
authors.lastname: Ribasés
authors.forename: E
authors.initials: E
authors.lastname: Cuenca-León
authors.forename: P
authors.initials: P
authors.lastname: Blanco-Arias
authors.forename: B
authors.initials: B
authors.lastname: Narberhaus
authors.forename: M
authors.initials: M
authors.lastname: Roig
authors.forename: R
authors.initials: R
authors.lastname: Leira
authors.forename: J
authors.initials: J
authors.lastname: López-González
authors.forename: A
authors.initials: A
authors.lastname: Macaya
authors.forename: B
authors.initials: B
authors.lastname: Cormand
mesh_terms: D016022:Case-Control Studies; D004296:Dopa Decarboxylase / Q000235:genetics; D004843:Epistasis, Genetic; D055106:Genome-Wide Association Study; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*; D008995:Monoamine Oxidase / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D044403:Receptor, Serotonin, 5-HT2B / Q000235:genetics*; D012701:Serotonin / Q000235:genetics*; D013030:Spain
chemical_list: D044403:Receptor, Serotonin, 5-HT2B; D012701:Serotonin; D008995:Monoamine Oxidase; D004296:Dopa Decarboxylase