title: Peripheral neuropathy in a cat with renal lymphoma.
abstract: A 12-year-old male cat was referred for progressive limb weakness lasting 2 weeks. Physical examination detected muscle atrophy and bilateral renomegaly with distortion of the renal contours. The cat was ambulatory but tetraparetic. It showed a peculiar posture on forelimbs with bilateral flexion of the carpi and extrarotation of forearms. The cat was unable to go upstairs or jump. Neurological examination showed findings compatible with peripheral nervous system involvement. Histopathological findings revealed a high grade non-B, non-T cell renal lymphoma and peripheral neuropathy characterised by demyelination, axonal degeneration and muscle denervation. In the absence of congenital, metabolic and infectious diseases or exposure to toxins, a paraneoplastic peripheral neuropathy was hypothesised. In humans and dogs, paraneoplastic peripheral neuropathies have been documented with different neoplastic processes including lymphoproliferative disorders. To the authors' knowledge, this is the first report of suspected paraneoplastic polyneuropathy in a cat with malignant tumour.
authors.affiliation: Section of Clinical Science, Department of Animal Pathology, Faculty of Veterinary Medicine, University of Turin, Grugliasco, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Cavana
authors.forename: Federica
authors.initials: F
authors.lastname: Sammartano
authors.forename: Maria T
authors.initials: MT
authors.lastname: Capucchio
authors.forename: Deborah
authors.initials: D
authors.lastname: Catalano
authors.forename: Alberto
authors.initials: A
authors.lastname: Valazza
authors.forename: Anna M
authors.initials: AM
authors.lastname: Farca
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D002371:Cat Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D002415:Cats; D037901:Euthanasia, Animal; D007680:Kidney Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D020364:Paraneoplastic Polyneuropathy / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D011241:Prednisone / Q000008:administration & dosage
chemical_list: D018931:Antineoplastic Agents, Hormonal; D011241:Prednisone