title: [S-1 activity in non-small cell lung cancer in clinical practice].
abstract: OBJECTIVE
  We evaluated retrospectively single-agent S-1 chemotherapy in non-small cell lung cancer patients in clinical practice.
  
  
  METHODS
  Sixteen consecutive patients treated with single-agent S-1 for NSCLC between July 2005 and June 2007 at the Department of Thoracic Surgery, Tsuchiura Kyodo General Hospital. The treatment schedule comprised oral administration of S-1 at 80-120 mg/day. One cycle of S-1 consisted of consecutive administration to 14 (10 cases)or 28(6 cases)days followed by a 14-day rest.
  
  
  RESULTS
  Patients profiles were: M/F: 11/5, median age 68 years old(range 51-83), PS 0/1/2/3: 2/6/5/3, adeno/squamous/large: 13/2/1, clinical stage 3A/3B/4: 3/4/9, prior chemotherapy regimens 0/1/2/3/4: 2/3/4/5/2, prior surgery/radiation: 12/5 were performed. Median number of delivered cycles was 5 cycles(range 1-13). Grade 3 hematological toxicities were anemia(6%)and thrombocytopenia(6%). Grade 3 non-hematological toxicities were nausea(6%)and vomiting(6%). Response of 13 patients could be evaluated after 2-4 cycles of S-1. Four partial responses were observed, for a response rate of 31%. The survival time was 67-852 days(average 14.0 months), 1-year survival rate was 74.0%, median time to progression was 4.6 m, and 1- year progression free survival was 25.0%.
  
  
  CONCLUSIONS
  Single-agent S-1 chemotherapy has modest activity and is the one of the important regimens and tolerable for elderly, poor-PS, recurrent patients with NSCLC in clinical practice.
authors.affiliation: Dept. of Thoracic Surgery, Tsuchiura Kyodo General Hospital.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Inagaki
authors.forename: Takuya
authors.initials: T
authors.lastname: Onuki
authors.forename: Kesato
authors.initials: K
authors.lastname: Iguchi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ogata
authors.forename: Yuri
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Saito
authors.forename: Yoko
authors.initials: Y
authors.lastname: Wakai
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Takabe
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Keiko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ohtani
authors.forename: Kenichi
authors.initials: K
authors.lastname: Horikoshi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015996:Survival Rate; D005641:Tegafur / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid