Bone mineral density in patients with familial Mediterranean fever.
This study was carried out to determine lumbar and femoral bone mineral density (BMD) in patients with familial Mediterranean fever (FMF), an autosomal-recessive disease characterized by recurrent episodes of peritonitis, pleuritis, and arthritis, which are usually associated with fever. In patients with FMF and control subjects, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured. BMD was determined at the lumbar spine (L1-4) and the femoral regions (neck and total) using dual energy X-ray absorptiometry. Twenty-eight FMF patients and 30 control subjects without a history of inflammatory disease participated in our study. The demographic variables, such as age, sex and body mass index were similar between patients and controls (P > 0.05). We found statistically significant difference in ESR and CRP between FMF patients and controls (P < 0.01, P < 0.05 respectively). There was statistically significant difference in lumbar spine, femoral neck, and total femur BMD between FMF patients and control groups (P < 0.001, P < 0.01, P < 0.01 respectively).Our study indicates that lumbar spine and femoral neck and total femur BMD in patients with FMF may be lower than in healthy subjects.
Yildirim
Kadir
K
Department of Physical Medicine, Medical Faculty, Ataturk University, Erzurum, Turkey. kadiryildirim88@hotmail.com
Karatay
Saliha
S
Cetinkaya
Ramazan
R
Uzkeser
Hulya
H
Erdal
Akin
A
Capoglu
Ilyas
I
Erdem
Fazile Hatipoglu
FH
D015502:Absorptiometry, Photon; D000328:Adult; D015415:Biomarkers; D001799:Blood Sedimentation; D015519:Bone Density / Q000235:genetics*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism; D018450:Disease Progression; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D011237:Predictive Value of Tests; D055815:Young Adult
D015415:Biomarkers; D002097:C-Reactive Protein