Four familial cases of epidermodysplasia verruciformis: mother and three sons.
Epidermodysplasia verruciformis (EV) is a rare genodermatosis associated with a high risk of skin cancer. In this report, we present three Iranian brothers and their mother with extensive seborrheic keratosis-like (SK-like) viral warts. Initial facial lesions developed in the first decade and disseminated with time. The patients showed SK-like viral warts characterized by dark brown or black pigmented proliferative lesions with hyperkeratotic surfaces. The histopathological findings were consistent with the diagnosis of EV. There are few reports of familial epidermodysplasia verruciformis especially in a mother and her three sons.
Robati
Reza Mahmoud
RM
Skin Research Center, Shahid Beheshti University, M.C. Shohada-e Tajrish Hospital, Tehran, Iran. rmrobati@gmail.com
Marefat
Afsaneh
A
Saeedi
Marjan
M
Rahmati-Roodsari
Mohammad
M
Asadi-Kani
Zahra
Z
D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D002648:Child; D003937:Diagnosis, Differential; D004198:Disease Susceptibility; D004819:Epidermodysplasia Verruciformis / Q000175:diagnosis / Q000235:genetics*; D005148:Facial Dermatoses / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006229:Hand Dermatoses / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D014010:Tinea Versicolor / Q000175:diagnosis