Medicinal chemistry and anti-inflammatory activity of nitric oxide-releasing NSAI drugs.
Nitric Oxide, which acts as a non-specific cytotoxic mediator and a biological messenger on immunological competence, has been gaining significantly increasing importance. As an alternative to conventional NSAIDs having significant side effects, pharmacologically improved and therapeutically enhanced NO releasing non-steroidal anti-inflammatory drugs with less side effects are being planned to produce.
Koç And
Esra
E
Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 34668, Turkey.
Küçükgüzel
S Güniz
SG
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D006801:Humans; D009569:Nitric Oxide / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009569:Nitric Oxide