Recurrent lung cancer in the mediastinum noticed after a living-donor lobar lung transplantation.
We describe a case of lung cancer in a living-donor lobar lung transplantation (LDLLT) recipient that was identified because of a recurrence in the mediastinum. The patient was a 55-year-old woman who had undergone bilateral LDLLT for nonspecific interstitial pneumonia. She developed dyspnea upon exertion at 15 months after transplantation and was diagnosed as suffering from chronic rejection. A computed tomography scan also revealed enlarged mediastinal lymph nodes (LNs) that were subsequently confirmed as poorly differentiated squamous cell carcinomas. Retrospectively, a small tumor was found in the explanted right lung tissue, the microscopic findings of which were similar to those of the mediastinal lesion. A whole body examination revealed no other lesions; thus we resected the LNs and subsequently irradiated the mediastinum. Recurrent disease appeared in her transplanted lungs 10 months after resection of the LNs, and she died of pneumonia with chronic rejection 2 years and 7 months after transplantation.
Toyooka
Shinichi
S
Department of Cancer and Thoracic Surgery, and Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Waki
Naohisa
N
Okazaki
Megumi
M
Kato
Katsuya
K
Yamane
Masaomi
M
Oto
Takahiro
T
Sano
Yoshifumi
Y
Date
Hiroshi
H
D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D002454:Cell Differentiation; D017809:Fatal Outcome; D005260:Female; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000601:surgery*; D019520:Living Donors; D008175:Lung Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D016040:Lung Transplantation / Q000009:adverse effects*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008479:Mediastinal Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018714:Radiotherapy, Adjuvant; D013249:Sternum / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome