title: Preparation, release profiles, and antibacterial properties of vancomycin-loaded poly(D,L-lactic) titanium alloy plates.
abstract: The rate of infection in closed fractures is low and ranges from 0.7% to 4.2%. Patients with open fractures are known to be at higher risk of infection (5%-30%). Internal fixation of fractures is widely used; however, implants allow bacteria to grow and propagate. Implant-associated infections are the chief risk facing orthopedic and traumatology departments. It would therefore be clinically advantageous to develop an internal fixation system that possesses anti-infection properties to prevent and cure implant infections. With poly(D,L)-lactic acid (PDLLA) as a carrier, PDLLA coatings carrying vancomycin were prepared on the surface of titanium alloy plate substrates for internal fixation of fractures using solvent-casting technology. The bacteriostatic activity to Staphylococcus aureus and the drug-release profile of the plates were evaluated in vitro. Vancomycin-loaded plates showed a sustained in vitro drug release character in the experiment. The in vitro inhibition of S aureus showed that the plates had an inhibitory effect on S aureus, and the antibacterial activity was maintained for at least 15 days. These findings may have important clinical significance for preventing acute infection after the fracture of internally implanted fixation plates.
authors.affiliation: Department of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: LiangHua
authors.initials: L
authors.lastname: Tang
authors.forename: ChangHong
authors.initials: C
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiong
authors.forename: ChangJiang
authors.initials: C
authors.lastname: Pan
authors.forename: AiMin
authors.initials: A
authors.lastname: Wang
mesh_terms: D000497:Alloys / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D001860:Bone Plates; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage*; D004058:Diffusion; D013211:Staphylococcus aureus / Q000166:cytology / Q000187:drug effects*; D014025:Titanium / Q000737:chemistry*; D014640:Vancomycin / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D000497:Alloys; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D014640:Vancomycin; D014025:Titanium