Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum.
Two new Lycopodium alkaloids, serratezomines D (1) and E (2), were isolated from the club moss Lycopodium serratum var. serratum. Serratezomine D (1) is a new lucidine-type alkaloid, while serratezomine E (2) is a new phlegmarane-type alkaloid. The structures and relative stereochemistry of 1 and 2 were elucidated on the basis of spectroscopic data. Serratezomine D (1) exhibited an inhibitory activity against acetylcholinesterase.
Kubota
Takaaki
T
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Yahata
Hiroko
H
Yamamoto
Sunao
S
Hayashi
Shigeki
S
Shibata
Toshiro
T
Kobayashi
Jun'ichi
J
D000110:Acetylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D032502:Lycopodium / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D006574:Heterocyclic Compounds, 2-Ring; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; D011804:Quinolines; C542897:serratezomine D; C542896:serratezomine E; D000110:Acetylcholinesterase