title: Kinetics and longevity of antibody response to influenza A H5N1 virus infection in humans.
abstract: Anti-H5N1 antibody was determined by microneutralization, hemagglutination inhibition, and Western blotting assays in serial blood samples collected from eight Thai patients, including four fatal cases and four survivors. The antibody was detected as early as 5 days and, typically, with an increase in titer in paired blood at about 15 days after disease onset. The anti-H5 antibody response was long-lasting, for almost 5 years in cases which can be followed that far. In addition, cross-neutralizing activity to related clade 1 viruses was observed.
authors.affiliation: National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Rungrueng
authors.initials: R
authors.lastname: Kitphati
authors.forename: Phisanu
authors.initials: P
authors.lastname: Pooruk
authors.forename: Hatairat
authors.initials: H
authors.lastname: Lerdsamran
authors.forename: Siriwan
authors.initials: S
authors.lastname: Poosuwan
authors.forename: Suda
authors.initials: S
authors.lastname: Louisirirotchanakul
authors.forename: Prasert
authors.initials: P
authors.lastname: Auewarakul
authors.forename: Kulkanya
authors.initials: K
authors.lastname: Chokphaibulkit
authors.forename: Pirom
authors.initials: P
authors.lastname: Noisumdaeng
authors.forename: Pathom
authors.initials: P
authors.lastname: Sawanpanyalert
authors.forename: Pilaipan
authors.initials: P
authors.lastname: Puthavathana
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000917:Antibody Formation; D015153:Blotting, Western; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D005260:Female; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D013785:Thailand; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; C109963:hemagglutinin, avian influenza A virus