title: Preparation of fenofibrate nanosuspension and study of its pharmacokinetic behavior in rats.
abstract: BACKGROUND
  In this study, nanosuspension was prepared to improve the dissolution rate and bioavailability of lipophilic fenofibrate.
  
  
  METHODS
  Melt emulsification method combined with high-pressure homogenization was adapted, and mixture of poloxamer188 and PVP K30 were selected as surfactants. This method consumed less energy and was more efficient than traditional homogenization of drug solid particles suspension directly.
  
  
  RESULTS
  The dissolution rate of fenofibrate nanosuspension was increased obviously, and the product was evaluated by pharmacokinetic characteristic in rats. The AUC(0-36 h) and C(max) of nanosuspensions were increased when compared with the reference formulations. No significant differences were found between the two nanosuspensions A and B, of which the mean particle sizes were 356 and 194 nm, respectively. Therefore, nanosuspensions may be a suitable delivery system to improve the bioavailability of those drugs with poor water solubility.
authors.affiliation: College of Life Science and Pharmaceutics, Nanjing University of Technology, Nanjing, China. xuemingli@njut.edu.cn
authors.forename: XueMing
authors.initials: X
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Gu
authors.forename: Yuanlong
authors.initials: Y
authors.lastname: Xu
authors.forename: Yonglu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D011345:Fenofibrate / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013535:Suspensions
chemical_list: D013535:Suspensions; D011345:Fenofibrate