Macroscopic extent of gastric mucosal atrophy: increased risk factor for esophageal squamous cell carcinoma in Japan.
BACKGROUND
We aimed to estimate whether the macroscopic extent of gastric mucosal atrophy is associated with a risk for esophageal squamous cell carcinoma using a case-control study in Japanese subjects, a population known to have a high prevalence of CagA-positive H. pylori infection.


METHODS
Two hundred and fifty-three patients who were diagnosed as having esophageal squamous cell carcinoma, and 253 sex- and age-matched controls were enrolled in the present study. The macroscopic extent of gastric mucosal atrophy was evaluated based on the Kimura and Takemoto Classification. A conditional logistic regression model with adjustment for potential confounding factors was used to assess the associations.


RESULTS
Body gastritis, defined endoscopically, was independently associated with an increased risk for esophageal squamous cell carcinoma.


CONCLUSIONS
Our findings suggest that macroscopic body gastritis may be a risk factor for esophageal squamous cell carcinoma in Japan. Further studies are needed to confirm these findings.
Akiyama
Tomoyuki
T
Gastroenterology Division, Yokohama City University School of Medicine, Yokohama, Japan. t066002g@yokohama-cu.ac.jp
Inamori
Masahiko
M
Iida
Hiroshi
H
Endo
Hiroki
H
Hosono
Kunihiro
K
Yoneda
Kyoko
K
Fujita
Koji
K
Yoneda
Masato
M
Takahashi
Hirokazu
H
Goto
Ayumu
A
Abe
Yasunobu
Y
Kirikoshi
Hiroyuki
H
Kobayashi
Noritoshi
N
Kubota
Kensuke
K
Saito
Satoru
S
Rino
Yasushi
Y
Nakajima
Atsushi
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000150:complications / Q000208:ethnology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000208:ethnology*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000208:ethnology*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000150:complications* / Q000208:ethnology / Q000473:pathology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors