title: Successful treatment of extreme acute lead intoxication.
abstract: Severe acute lead intoxications are rare and are associated with accidental or purposeful ingestion. There were only few cases of severe to fatal poisonings reported in literature in children. We report a case of acute lead intoxication in a child with extremely high lead blood level of 20.4 micromol/L (422.7 microg/dL), who was treated with chelation and in whom significant organ dysfunction did not develop. Documented significant high level above 3.37 micromol/L (corresponding to 70 microg/dL) in this patient persisted for approximately 24 h. Adequate, single or combined chelatation therapy in early phase of acute lead poisoning is essential for the further patient's outcome.
authors.affiliation: Department of Pediatrics, Jessenius School of Medicine, Comenius University in Bratislava, University hospital in Martin, Martin, Slovak Republic.
authors.forename: J
authors.initials: J
authors.lastname: Mikler
authors.forename: P
authors.initials: P
authors.lastname: Banovcin
authors.forename: M
authors.initials: M
authors.lastname: Jesenak
authors.forename: J
authors.initials: J
authors.lastname: Hamzikova
authors.forename: D
authors.initials: D
authors.lastname: Statelova
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000622:Aminolevulinic Acid / Q000097:blood; D000931:Antidotes / Q000627:therapeutic use*; D002606:Charcoal / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use*; D004492:Edetic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007854:Lead / Q000378:metabolism; D007855:Lead Poisoning / Q000378:metabolism / Q000628:therapy*; D009566:Nitrates / Q000378:metabolism / Q000506:poisoning*; D013406:Suicide, Attempted; D007507:Therapeutic Irrigation; D016896:Treatment Outcome
chemical_list: D000931:Antidotes; D002614:Chelating Agents; D009566:Nitrates; D002606:Charcoal; D007854:Lead; C017461:lead nitrate; D000622:Aminolevulinic Acid; D004492:Edetic Acid