title: Recognition and characterization of small colonic neoplasia with high-definition colonoscopy using i-Scan is as precise as chromoendoscopy.
abstract: BACKGROUND
  The EPKi system (Pentax, Japan) enables resolution above HDTV. Aim of the study was to test the efficacy of HD+ alone and with the new post-processing digital filter i-Scan or chromoendoscopy (Methylene blue 0.1%) in screening for colorectal cancer. We focused on lesions less than 5 mm as a surrogate marker for the optical possibilities of the EPKi system.
  
  
  METHODS
  The last 30 cm of the colon in a screening population were inspected with HD+ alone, in combination with i-Scan (2:1 randomisation) and subsequently with chromoendoscopy. All lesions were characterized and targeted biopsies were performed.
  
  
  RESULTS
  i-Scan augmented in 69 patients the identification of lesions from 176 to 335 (p<0.001) and chromoendoscopy to 646 (p<0.001). The additional lesions were mainly flat (type IIb, 74%), which were only recognized using i-Scan or chromoendoscopy. The amount of neoplasias was not significantly different (HD+: 5, i-Scan: 11, Chromoendoscopy: 11), but all could correctly be predicted using i-Scan or chromoendoscopy.
  
  
  CONCLUSIONS
  HD+ colonoscopy with and without i-Scan unmask a plethora of small lesions but chromoendoscopy can even advance the number. However, i-Scan was able to predict neoplasia as precisely as chromoendoscopy and might shortly replace chromoendoscopy as a more time efficient tool.
authors.affiliation: I. Med. Clinic, Johannes Gutenberg University Mainz, Germany. AHoff66286@aol.com
authors.forename: A
authors.initials: A
authors.lastname: Hoffman
authors.forename: C
authors.initials: C
authors.lastname: Kagel
authors.forename: M
authors.initials: M
authors.lastname: Goetz
authors.forename: A
authors.initials: A
authors.lastname: Tresch
authors.forename: J
authors.initials: J
authors.lastname: Mudter
authors.forename: S
authors.initials: S
authors.lastname: Biesterfeld
authors.forename: P R
authors.initials: PR
authors.lastname: Galle
authors.forename: M F
authors.initials: MF
authors.lastname: Neurath
authors.forename: R
authors.initials: R
authors.lastname: Kiesslich
mesh_terms: D000236:Adenoma / Q000473:pathology*; D003111:Colonic Polyps / Q000473:pathology*; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008751:Methylene Blue; D008875:Middle Aged
chemical_list: D008751:Methylene Blue