title: Effects of mosapride on motility of the small intestine and caecum in normal horses after jejunocaecostomy.
abstract: The purpose of the present study was to evaluate the prokinetic effects of mosapride with non-invasive assessment of myoelectrical activity in the small intestine and caecum of healthy horses after jejunocaecostomy. Six horses underwent celiotomy and jejunocaecostomy, and were treated with mosapride (treated group) at 1.5 mg/kg per osos once daily for 5 days after surgery. The other six horses did not receive treatment and were used as controls (non-treated group). The electrointestinography (EIG) maximum amplitude was used to measure intestinal motility. Motility significantly decreased following surgery. In the treated group, the EIG maximum amplitude of the small intestine was significantly higher than in the controls from day 6 approximately 31 after treatment. These findings clearly indicate that mosapride could overcome the decline of intestinal motility after jejunocaecostomy in normal horses.
authors.affiliation: The United Graduate School of Veterinary Sciences, Gifu University, Gifu-shi, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Okamura
authors.forename: Naoki
authors.initials: N
authors.lastname: Sasaki
authors.forename: Takuya
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Aya
authors.initials: A
authors.lastname: Murata
authors.forename: Inhyung
authors.initials: I
authors.lastname: Lee
authors.forename: Haruo
authors.initials: H
authors.lastname: Yamada
authors.forename: Hisashi
authors.initials: H
authors.lastname: Inokuma
mesh_terms: D000714:Anastomosis, Surgical / Q000662:veterinary; D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D002432:Cecum / Q000187:drug effects* / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006736:Horses / Q000502:physiology* / Q000601:surgery; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D007582:Jejunostomy / Q000662:veterinary; D008297:Male; D009025:Morpholines / Q000494:pharmacology*
chemical_list: D001549:Benzamides; D005765:Gastrointestinal Agents; D009025:Morpholines; C062720:mosapride