Testosterone therapy in men.
Androgens exert effects on virtually all bodily tissues, and have a multitude of physiological roles in health. Testosterone, the predominant androgen in men, when deficient (hypogonadism), leads to a multiplicity of symptoms and signs that are corrected with physiological substitution. The impact of hypogonadism depends on the age at which it occurs. In any case, when testosterone replacement is initiated close monitoring for efficacy and safety is advised. The relation of ageing, the metabolic syndrome, type 2 diabetes, obesity and survival with plasma testosterone has been closely examined in recent studies. However, the effect of testosterone replacement therapy on the above clinical states needs to be clarified in large long-term duration/outcome studies. Recent research has shed light on possible molecular testosterone targets. Based on those research outcomes, drugs targeting the androgen receptor, which spare androgenic effects and preserve anabolic tissue effects, called selective androgen receptor modulators (SARMS), are under clinical trials. The role of testosterone in regulating erectile function has been studied in animal models and critical tissue testosterone targets have been elucidated.
Theodoraki
Aikaterini
A
Centre for Neuroendocrinology, Royal Free Campus, University College Medical School, Rowland Hill Street, London NW3 2PF, UK. k_theodoraki@yahoo.gr
Bouloux
Pierre-Marc
PM
D047649:Andropause / Q000187:drug effects*; D000818:Animals; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D007172:Erectile Dysfunction / Q000188:drug therapy; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy; D008297:Male; D054526:Men's Health; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy; D012107:Research Design; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*; D013739:Testosterone / Q000627:therapeutic use*
D020845:Selective Estrogen Receptor Modulators; D013739:Testosterone