title: Increased rat serum corticosterone suggests immunomodulation by stimulation of the vagal nerve.
abstract: The role of the vagal nerve within the immune system has not been fully elucidated. Vagal afferents connect to several central nervous system structures, including the hypothalamus. We investigated the effect of vagal nerve stimulation (VNS) on serum corticosterone levels in rats. Corticosterone levels were measured following 1 h of high frequency (30 Hz) or low frequency (1 Hz) VNS in awake animals. There was a significant increase (p < 0.05) in serum corticosterone levels following 30 Hz VNS compared to 1 Hz VNS or sham stimulation. These results suggest an immediate effect of VNS on the hypothalamic pituitary-adrenal (HPA) axis and support the role of the vagal nerve in immunomodulation.
authors.affiliation: Laboratory for Clinical and Experimental Neurophysiology, Reference Center for Refractory Epilepsy, Department of Neurology 1K12IA, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Veerle.Deherdt@UGent.be
authors.forename: V
authors.initials: V
authors.lastname: De Herdt
authors.forename: L
authors.initials: L
authors.lastname: Puimege
authors.forename: J
authors.initials: J
authors.lastname: De Waele
authors.forename: R
authors.initials: R
authors.lastname: Raedt
authors.forename: T
authors.initials: T
authors.lastname: Wyckhuys
authors.forename: R
authors.initials: R
authors.lastname: El Tahry
authors.forename: C
authors.initials: C
authors.lastname: Libert
authors.forename: W
authors.initials: W
authors.lastname: Wadman
authors.forename: P
authors.initials: P
authors.lastname: Boon
authors.forename: K
authors.initials: K
authors.lastname: Vonck
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D055536:Vagus Nerve Stimulation
chemical_list: D000324:Adrenocorticotropic Hormone; D003345:Corticosterone