title: Pleomorphic carcinoma of the lung in which the sarcomatous element grew rapidly: a case report.
abstract: We report a case of pleomorphic carcinoma of the lung that showed a rapid growth. The patient was a 77-year-old female with an abnormality detected in her chest radiograph during a screening examination, but a definite diagnosis could not be obtained based on a needle biopsy guided by CT. After one month, the tumor had continued to grown rapidly and lung cancer was strongly suspected, so the patient underwent surgery. The intraoperative diagnosis demonstrated it to be a pleomorphic carcinoma of the lung in which a squamous element and a sarcomatous element were mixed; and a right lower lobectomy and lymphadenectomy were performed. In a pathological examination after surgery, the tumor was found to be composed of a sarcomatous element that had a high MIB-1 index of 30%, and this was believed to be the cause of the rapid growth.
authors.affiliation: Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Fujioka
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yoshin
authors.initials: Y
authors.lastname: Adachi
authors.forename: Ken
authors.initials: K
authors.lastname: Miwa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Haruki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: Hisao
authors.initials: H
authors.lastname: Ito
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D001999:Bronchoscopy; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002296:Carcinosarcoma / Q000473:pathology* / Q000601:surgery; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008197:Lymph Node Excision; D009367:Neoplasm Staging; D011013:Pneumonectomy; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D019394:Ki-67 Antigen