[Progress in the research on multi-target-directed drugs against Alzheimer's disease].
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and one of the earliest sings of AD is deficit in short term memory. Till now, the pathogenesis of AD has not been elucidated and the present one-drug-one-target paradigm of anti-AD-drug treatment seems not to be effective in clinic. Multi-target-directed anti-AD-drugs are those agents that may act on two or more targets implicated in AD. Based on the brief introduction of progress in the development of present anti-AD-drugs, the paper mainly focused on the advances in the field of multi-target-directed drug development both home and abroad, especially those studies on selective estrogen receptor modulators.
Liu
Rui-ting
RT
Genova (Beijing) Biopharmaceutical Research Institute, Beijing 100102, China.
Lü
Qiu-jun
QJ
D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D007211:Indoles / Q000627:therapeutic use; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*; D013619:Tacrine / Q000031:analogs & derivatives / Q000627:therapeutic use; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
C423264:(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007189:Indans; D007211:Indoles; D020845:Selective Estrogen Receptor Modulators; C540521:lipocrine; D013619:Tacrine; D008063:Thioctic Acid; C010119:latrepirdine