title: Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation.
abstract: Cell adhesion in endometrial epithelium is regulated to maintain the continuity and protectiveness of the luminal covering cell layer while permitting interstitial implantation of the embryo during a restricted period of about 4 days. Many apparently normal embryos fail to implant, and epithelial-embryo adhesion remains a poorly understood phenomenon. After menstruation, epithelial regeneration occurs by epiboly from the basal residues of glands, an activity that requires migration on extracellular matrix as well as cell-cell cohesion. Here we review current knowledge of adhesion molecules in the epithelium.
authors.affiliation: Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK.
authors.forename: Harmeet
authors.initials: H
authors.lastname: Singh
authors.forename: John D
authors.initials: JD
authors.lastname: Aplin
mesh_terms: D015820:Cadherins / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D010064:Embryo Implantation / Q000502:physiology*; D004717:Endometrium / Q000502:physiology*; D004848:Epithelium / Q000502:physiology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000502:physiology; D016023:Integrins / Q000502:physiology
chemical_list: D015820:Cadherins; D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D016023:Integrins