Synthesis of substituted pyridines and pyridazines via ring closing metathesis.
RCM can be used to make aromatic heterocycles, namely pyridines and, for the first time, pyridazines; the key step after RCM involves elimination of sulfinate to provide the aromatic system.
Donohoe
Timothy J
TJ
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK OX1 3TA. timothy.donohoe@chem.ox.ac.uk
Fishlock
Lisa P
LP
Basutto
José A
JA
Bower
John F
JF
Procopiou
Panayiotis A
PA
Thompson
Amber L
AL
D003500:Cyclization; D011724:Pyridazines / Q000138:chemical synthesis*; D011725:Pyridines / Q000138:chemical synthesis*
D011724:Pyridazines; D011725:Pyridines