[Snake venoms C-type lectins and their receptors on platelets and cancerous cells].
Snake venoms are a rich natural source of bioactive molecules, such as peptides, proteins and enzymes, more and more used in biomedical research in diagnostic or therapeutic purposes. The protein components of snake venoms belong to diverse families such as serine proteases, phospholipases, disintegrins, metalloproteinases and C-type lectins. Due to their effects on various receptors such as GPIb, GPVI, alpha2beta1..., the C-type lectins were considered, in first time, as modulators of the platelet aggregation. Recently, some of them have been described for their anti-tumoral potential effect due to their capacity to inhibit adhesion, migration, proliferation and invasion of different cancer cell lines. Also, the C-type lectins have a powerful antiangiogenic effect in vivo and in vitro by interacting with integrins of endothelial cells.
Sarray
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Laboratoire des venins et toxines, Institut Pasteur de Tunis, Tunis, Tunisie. sameh_sarray@yahoo.fr
Luis
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El Ayeb
M
M
Marrakchi
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N
D000818:Animals; D045744:Cell Line, Tumor / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D038982:Integrin alpha2beta1 / Q000187:drug effects; D039081:Integrin alpha5beta1 / Q000187:drug effects; D037181:Lectins, C-Type / Q000737:chemistry / Q000627:therapeutic use*; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D010974:Platelet Aggregation / Q000187:drug effects*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000187:drug effects; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000187:drug effects; D012910:Snake Venoms / Q000737:chemistry*
D038982:Integrin alpha2beta1; D039081:Integrin alpha5beta1; D037181:Lectins, C-Type; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; D012910:Snake Venoms