Severe hemophagocytic syndrome developing after treatment initiation for disseminated Mycobacterium tuberculosis: case report and literature review.
We describe a case of a young male with disseminated tuberculosis and severe secondary hemophagocytic syndrome. He presented with symptoms of tuberculosis and Mycobacterium tuberculosis was diagnosed. Later, while on anti-tuberculous treatment, he developed pancytopenia and bone marrow aspirate showed large macrophages with increased phagocytosis of mature and immature blood elements typical of hemophagocytic syndrome.
Balkis
Maher M
MM
Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Bazzi
Lama
L
Taher
Ali
A
Salem
Ziad
Z
Uthman
Imad
I
Kanj
Nadim
N
Boulos
Fouad I
FI
Kanj
Souha S
SS
D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology; D008297:Male; D009169:Mycobacterium tuberculosis; D016896:Treatment Outcome; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy
D000995:Antitubercular Agents