title: [A case of hypopigmentation triggered by S-1].
abstract: Right partial glossectomy and supraomohyoid neck dissection were performed on a 65-year-old man with tongue squamous cell carcinoma. Postoperatively, S-1(80-120 mg/day)was administered as adjuvant chemotherapy. Six months later, an eruption accompanied by abdominal itching was recognized. Then leukoderma appeared on his face and both hands, continued to spread and it was diagnosed by dermatology as hypopigmentation. He has been doing well without any recurrence for 4 years, but the hypopigmentation remains unchanged.
authors.affiliation: Dept. of Oral Surgery, Gifu Municipal Hospital.
authors.forename: Iwao
authors.initials: I
authors.lastname: Hyodo
authors.forename: Masahide
authors.initials: M
authors.lastname: Ota
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D017496:Hypopigmentation / Q000139:chemically induced*; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D012074:Remission Induction; D005641:Tegafur / Q000627:therapeutic use*; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid