title: Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.
abstract: Several 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared starting from acridine and their telomeric G-quadruplex stabilizing properties were evaluated using FRET melting and TRAP (Telomerase Repeat Amplification Protocol Assay) experiments.
authors.affiliation: Université de Reims-Champagne-Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, IFR 53 Biomolécules, Faculté de Pharmacie, 51 rue de Cognacq-Jay, F-51096 Reims, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Laronze-Cochard
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Kim
authors.forename: Bertrand
authors.initials: B
authors.lastname: Brassart
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Riou
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Laronze
authors.forename: Janos
authors.initials: J
authors.lastname: Sapi
mesh_terms: D000166:Acridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000378:metabolism; D016615:Telomere / Q000187:drug effects*
chemical_list: D000166:Acridines; D000970:Antineoplastic Agents; D008024:Ligands; D019098:Telomerase