title: Quantitative comparison of delta P1 versus optical diffusion approximations for modeling near-infrared gold nanoshell heating.
abstract: Laser induced thermal therapy combined with the wavelength dependent optical absorption and heating power of gold-coated silica nanoshells can achieve therapeutic heating localized to a tumor volume. Accurate modeling of the spatiotemperal thermal distribution associated with this heating is essential for accurate thermal therapy treatment planning. The optical diffusion approximation (ODA), used in numerous applications of laser fluence in biology, is compared to the delta P1 optical approximation in phantoms containing different concentrations of nanoshells for several laser powers. Results are compared with temperature maps generated by magnetic resonance temperature imaging techniques and show that the delta P1 approximation is more effective than ODA at modeling the thermal distribution. The discrepancy between the two is especially prominent in phantoms with higher nanoshell concentrations where ODA was shown to give unsatisfactory results.
authors.affiliation: Department of Imaging Physics, Unit 56, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas 77030, USA. andrew.elliott@di.mdacc.tmc.edu
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Elliott
authors.forename: Jon
authors.initials: J
authors.lastname: Schwartz
authors.forename: James
authors.initials: J
authors.lastname: Wang
authors.forename: Anil M
authors.initials: AM
authors.lastname: Shetty
authors.forename: Chirs
authors.initials: C
authors.lastname: Bourgoyne
authors.forename: D Patrick
authors.initials: DP
authors.lastname: O'Neal
authors.forename: John D
authors.initials: JD
authors.lastname: Hazle
authors.forename: R Jason
authors.initials: RJ
authors.lastname: Stafford
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004058:Diffusion; D004867:Equipment Design; D005782:Gels; D006046:Gold / Q000737:chemistry*; D007834:Lasers; D053768:Metal Nanoparticles / Q000737:chemistry; D015233:Models, Statistical; D036103:Nanotechnology / Q000379:methods; D016011:Normal Distribution; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D012822:Silicon Dioxide / Q000737:chemistry; D013696:Temperature
chemical_list: D005782:Gels; D006046:Gold; D012822:Silicon Dioxide