Substituent diversity-directed synthesis of indole derivatives.
This paper reports a versatile, good-yielding, solution-phase method that is a substituent diversity-directed synthesis of 1H-indoles (6-13, 17-20) and 1-hydroxyindoles (14, 15) starting from commercially available 1,5-difluoro-2,4-dinitrobenzene. The synthetic products possessed the maximum six diversity points.
Wang
Dong Mei
DM
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, #2 Nan Wei Road, Beijing, P. R. China.
Sun
Ming Na
MN
Liu
Gang
G
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004139:Dinitrofluorobenzene / Q000031:analogs & derivatives / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry
D007211:Indoles; D004139:Dinitrofluorobenzene; C002041:1,5-difluoro-2,4-dinitrobenzene