[Contents of serum Cyst-C and urinary microalbumin in children with Henoch-Schonlein purpura].
OBJECTIVE
To investigate the clinical significance of serum Cyst-C and urinary microalbumin in early renal impairment in children with Henoch-Schonlein purpura (HSP).


METHODS
Forty-eight children with HSP and who had normal serum creatinine level and 31 healthy children were enrolled. Contents of serum Cyst-C and urinary microalbumin were measured using ELISA and immunoturbidimetry, respectively. Urinary routine examination was performed in children with HSP. The contents of serum Cyst-C and urinary microalbumin were re-examined one month after treatment (recovery phase).


RESULTS
The contents of serum Cyst-C (2.24+/- 0.81 mg/L) and urinary microalbumin (20.04+/- 10.32 mg/L) in the HSP group at the acute phase were significantly higher than those in the control (0.85+/- 0.20 and 2.30+/- 1.38 mg/L respectively; P< 0.01). Serum Cyst-C (1.70+/- 0.30 mg/L) and urinary microalbumin contents (13.20+/- 8.16 mg/L) were significantly reduced at the recovery phase compared with those at the acute phase in the HSP group (P< 0.01). The proportion of urinary routine abnormality (33.3%) was significantly lower than that of urinary microalbumin (68.8%) and serum Cyst-C abnormalities (72.9%) in the HSP group (P< 0.01).


CONCLUSIONS
Serum Cyst-C and urinary microalbumin may serve as indexes in the assessment of early renal impairment in children with HSP.
Lu
Xiao-Ping
XP
Department of Pediatrics, First Hospital of Jiaxing,Jiaxing, Zhejiang, China. luxpjy@126.com
Shen
Wen-Juan
WJ
D000293:Adolescent; D000419:Albuminuria / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D003401:Creatine / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000150:complications* / Q000652:urine; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology; D008297:Male
D055316:Cystatin C; D003401:Creatine