Polycations. 17. Synthesis and properties of polycationic derivatives of carbohydrates.
In our continuing investigation of polycationic salts for purposes of antimicrobial action, ion-channel blocking, and construction of ionic liquids, we have prepared several series of polycationic salts derived from carbohydrate precursors. These salts are currently being investigated for optimal efficacy as antibacterials and antifungals, as well as for other applications. The syntheses of such series of salts are described here along with preliminary antibacterial testing results and a discussion of their properties indicating their potential utility for several purposes.
Thomas
Marie
M
Department of Chemistry and Biochemistry, Queens College CUNY, 65-30 Kissena Boulevard, Flushing, NY 11367, USA.
Montenegro
Diego
D
Castaño
Alejandra
A
Friedman
Laura
L
Leb
Jay
J
Huang
Mia Lace
ML
Rothman
Leah
L
Lee
Heidi
H
Capodiferro
Craig
C
Ambinder
Daniel
D
Cere
Eva
E
Galante
Jessica
J
Rizzo
JaimeLee
J
Melkonian
Karin
K
Engel
Robert
R
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D005782:Gels; D005960:Glucosides / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013402:Sugar Alcohols / Q000737:chemistry
D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D005782:Gels; D005960:Glucosides; D013402:Sugar Alcohols