title: DNA origami as a nanoscale template for protein assembly.
abstract: We describe two general approaches to the utilization of DNA origami structures for the assembly of materials. In one approach, DNA origami is used as a prefabricated template for subsequent assembly of materials. In the other, materials are assembled simultaneously with the DNA origami, i.e. the DNA origami technique is used to drive the assembly of materials. Fabrication of complex protein structures is demonstrated by these two approaches. The latter approach has the potential to be extended to the assembly of multiple materials with single attachment chemistry.
authors.affiliation: Nanoscience Center, Department of Physics, University of Jyväskylä, Finland.
authors.forename: Anton
authors.initials: A
authors.lastname: Kuzyk
authors.forename: Kimmo T
authors.initials: KT
authors.lastname: Laitinen
authors.forename: Päivi
authors.initials: P
authors.lastname: Törmä
mesh_terms: D004247:DNA / Q000737:chemistry*; D046912:Multiprotein Complexes / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D055503:Protein Multimerization; D019809:Streptavidin / Q000737:chemistry
chemical_list: D046912:Multiprotein Complexes; D004247:DNA; D019809:Streptavidin