Levetiracetam-induced platelet dysfunction.
Levetiracetam is an antiepileptic drug widely prescribed. We report here for the first time, an alteration of platelet function attributable to this drug. This effect has never been reported before. The responsibility of levetiracetam seems to be probable: restoration of platelet functionality was observed after withholding this treatment and this effect has been described for a structurally related molecule, piracetam.
Hacquard
Marie
M
Hématologie Biologique, CHU Nancy, allée du Morvan, Vandoeuvre-les-Nancy, France. m.toussaint-hacquard@chu-nancy.fr
Richard
Sébastien
S
Lacour
Jean-Christophe
JC
Lecompte
Thomas
T
Vespignani
Hervé
H
D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D001791:Blood Platelet Disorders / Q000139:chemically induced* / Q000473:pathology; D000077144:Clopidogrel; D006801:Humans; D000077287:Levetiracetam; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
D000927:Anticonvulsants; D010975:Platelet Aggregation Inhibitors; D000077287:Levetiracetam; D000077144:Clopidogrel; D013988:Ticlopidine; D010889:Piracetam