Concurrent decline of several antioxidants and markers of oxidative stress during combination chemotherapy for small cell lung cancer.
OBJECTIVE
To investigate the oxidant effects of adriamycin-containing chemotherapy (CT), we evaluated various antioxidants, total antioxidant capacity (TRAP) and different parameters of oxidative and nitrosative stress during combination CT.


METHODS
Blood samples were obtained from 16 small cell lung cancer patients at baseline and several times during the first, second and sixth CT cycles.


RESULTS
There were significant decreases in serum urate and serum proteins during all cycles, serum TRAP during the first two cycles, plasma ascorbic acid and serum TBARS during the first cycle, and serum conjugated dienes and plasma alphatocopherol during the last cycle. The baseline levels of tocopherols increased significantly between the first and sixth CT cycles. Higher levels of baseline plasma thiols were associated with better overall survival (p=0.008).


CONCLUSIONS
Adriamycin-containing CT causes significant oxidative stress as implied by reduced levels of protective antioxidants. Long-term CT treatment seems to enhance lipid peroxidation.
Crohns
Marika
M
Department of Oncology, University of Tampere, Finland. macro1@sci.fi
Liippo
Kari
K
Erhola
Marina
M
Kankaanranta
Hannu
H
Moilanen
Eeva
E
Alho
Hannu
H
Kellokumpu-Lehtinen
Pirkko
P
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D055752:Small Cell Lung Carcinoma / Q000097:blood / Q000188:drug therapy; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D017392:Thiobarbituric Acid Reactive Substances