Nesfatin-1: an overview and future clinical application.
Nesfatin/nucleobindin 2 (NUCB2) is expressed in the appetite-control hypothalamic nuclei and brainstem nuclei. Nesfatin/NUCB2 expression in the paraventricular nucleus of the hypothalamus was modulated by starvation and refeeding. Intracerebroventricular administration of nesfatin-1 dose-dependently inhibited food intake for 6 hours in male Wistar and leptin resistant, Zucker fatty rats. Intraperitoneal administration of nesfatin-1 and its mid-segment (M30) dosedependentlyinhibited food intake for 3 hours in male ICR mice. Intraperitoneal administration of M30 also decreased foodintake in leptin-resistant, genetically obese (ob/ob), diabetic (db/db) mice and mice fed a 45% high fat diet for 28 days. Intraperitoneal administration of M30 increased proopiomelanocortin and cocaine- and amphetamine- related peptide mRNA expression in the nucleus of the solitary tract of mice. In addition, intranasal administration of nesfatin-1 significantly inhibited food intake for 6 hours in male Wistar rats. We summarize recent observations about nesfatin-1, and attempt to present future direction of nesfatin-1 research for developing a new anti-obesity treatment.
Shimizu
Hiroyuki
H
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan. hshimizu@showa.gunma-u.ac.jp
Oh-I
Sinsuke
S
Okada
Shuichi
S
Mori
Masatomo
M
D000595:Amino Acid Sequence; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D002135:Calcium-Binding Proteins / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D004435:Eating / Q000187:drug effects*; D008297:Male; D051379:Mice; D008820:Mice, Obese; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000502:physiology*; D000080866:Nucleobindins; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011924:Rats, Zucker; D016415:Sequence Alignment
D001067:Appetite Depressants; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C000630651:Nucb1 protein, mouse; C000630652:Nucb1 protein, rat; D000080866:Nucleobindins; D010446:Peptide Fragments