Prediction, progression, and outcomes of chronic kidney disease in older adults.
Chronic kidney disease is a large and growing problem among aging populations. Although progression of chronic kidney disease to end-stage renal disease (ESRD) is a costly and important clinical event with substantial morbidity, it appears less frequently in aging people compared with cardiovascular mortality. The measurement of kidney function and management of kidney disease in older individuals remain challenging, partly because the pathophysiologic mechanisms underlying age-related decline in kidney function, the interactions between age and other risk factors in renal progression, and the associations of chronic kidney disease with other comorbidities in older people are understudied and poorly understood. The Association of Specialty Professors, the American Society of Nephrology, the American Geriatrics Society, the National Institute on Aging, and the National Institute of Diabetes and Digestive and Kidney Diseases held a workshop, summarized in this article, to review what is known about chronic kidney disease, identify research gaps and resources available to address them, and identify priority areas for future research. Answers to emerging research questions will support the integration of geriatrics and nephrology and thus improve care for older patients at risk for chronic kidney disease.
Anderson
Sharon
S
Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Halter
Jeffrey B
JB
Hazzard
William R
WR
Himmelfarb
Jonathan
J
Horne
Frances McFarland
FM
Kaysen
George A
GA
Kusek
John W
JW
Nayfield
Susan G
SG
Schmader
Kenneth
K
Tian
Ying
Y
Ashworth
John R
JR
Clayton
Charles P
CP
Parker
Ryan P
RP
Tarver
Erika D
ED
Woolard
Nancy F
NF
High
Kevin P
KP
D058186:Acute Kidney Injury / Q000150:complications; D000368:Aged; D000375:Aging / Q000502:physiology; D035843:Biomedical Research; D002318:Cardiovascular Diseases / Q000150:complications / Q000401:mortality; D015897:Comorbidity; D018450:Disease Progression; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000401:mortality / Q000628:therapy