title: Epileptic seizures and survival in early disease of grade 2 gliomas.
abstract: OBJECTIVE
  The aims of this study were (i) to determine the correlation between seizure activity and the metabolic rate of the tumour measured by (11)C-methionine PET (MET PET) in patients with grade 2 gliomas, and (ii) to assess the prognostic impact of early seizure manifestations on patient survival.
  
  
  METHODS
  In this retrospective review, early seizure manifestations were studied in 101 patients with supratentorial grade 2 gliomas subjected to MET PET as part of the pre-treatment tumour investigation. Seizure manifestations as a variable was then used in multivariate survival analyses, together with established prognostic factors for this patient group.
  
  
  RESULTS
  Of all 101 cases, 88 patients had seizures at tumour presentation. Forty-seven were seizure free at the early stage of the disease, whereas 54 had recurrent seizures. Patients with seizures at tumour presentation had a more favourable outcome before and after (P = 0.006) adjustment for conventional prognostic factors. However, for those who continued to have seizures early in the disease, the outcome was worse (P = 0.003). We found no significant correlation between MET PET and the seizure manifestations of the patients.
  
  
  CONCLUSIONS
  The presence and termination of early seizure manifestations may be favourable prognostic factors in patients with low-grade gliomas.
authors.affiliation: Department of Neuroscience, University Hospital, Uppsala, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Danfors
authors.forename: D
authors.initials: D
authors.lastname: Ribom
authors.forename: S G
authors.initials: SG
authors.lastname: Berntsson
authors.forename: A
authors.initials: A
authors.lastname: Smits
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality*; D002247:Carbon Isotopes / Q000378:metabolism; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D005910:Glioma / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality* / Q000601:surgery; D006801:Humans; D008297:Male; D008715:Methionine / Q000378:metabolism; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D012044:Regression Analysis; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D002247:Carbon Isotopes; D008715:Methionine