Human papillomavirus-58 and -73-associated digital squamous cell carcinoma in a patient with aggressive digital papillary adenocarcinoma.
Aggressive digital papillary adenocarcinoma (ADPA) is a rare tumor that is considered to arise from eccrine sweat glands of the skin. It occurs predominantly in men with a mean age in the sixth decade. It shows a strong tendency for local recurrence and has the potential to metastasize to distant sites. Prompt diagnosis and regular follow-up are important to ensure the best possible outcome. We discuss a case of recurrent ADPA associated with subsequent squamous cell carcinoma (SCC) in different contralateral digits in a 55-year-old man. One SCC lesion tested positive for human papillomavirus (HPV)-58. HPV-associated digital SCCs have been reported; most cases are HPV-16 positive. This report describes a rare case of an HPV-58-positive invasive digital SCC and an HPV-73-positive SCC in situ associated with ADPA.
DePond
William
W
Department of Pathology, University of Missouri-Kansas City, School of Medicine, Truman Medical Center, Kansas City, MO, USA.
Kure
Kiyoe
K
Lankachandra
Kamani
K
Gidwani
Raja
R
Nelson
Brook V
BV
Zimmerman
Hannah
H
Talboy
Glenn E
GE
Miranda
Roberto N
RN
D000231:Adenocarcinoma, Papillary / Q000473:pathology / Q000821:virology*; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D005385:Fingers / Q000473:pathology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology / Q000821:virology*