title: Bioactivity of grape chemicals for human health.
abstract: Grapevine (Vitis vinifera) products, grape and grape juice, represent a valuable source of bioactive phytochemicals, synthesized by three secondary metabolic pathways (phenylpropanoid, isoprenoid and alkaloid biosynthetic routes) and stored in different plant tissues. In the last decades, compelling evidence suggested that regular consumption of these products may contribute to reducing the incidence of chronic illnesses, such as cancer, cardiovascular diseases, ischemic stroke, neurodegenerative disorders and aging, in a context of the Mediterranean dietary tradition. The health benefits arising from grape product intake can be ascribed to the potpourri of biologically active chemicals occurring in grapes. Among them, the recently discovered presence of melatonin adds a new element to the already complex grape chemistry. Melatonin, and its possible synergistic action with the great variety of polyphenols, contributes to further explaining the observed health benefits associated with regular grape product consumption.
authors.affiliation: Dipartimento di Produzione Vegetale, Università di Milano, Via Celoria 2, 20133 Milano, Italy. marcello.iriti@unimi.it
authors.forename: Marcello
authors.initials: M
authors.lastname: Iriti
authors.forename: Franco
authors.initials: F
authors.lastname: Faoro
mesh_terms: D000375:Aging / Q000187:drug effects; D000470:Alkaloids / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D050197:Atherosclerosis / Q000188:drug therapy; D002316:Cardiotonic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D018890:Chemoprevention; D005419:Flavonoids / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008550:Melatonin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D027843:Vitis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D002316:Cardiotonic Agents; D005419:Flavonoids; D018696:Neuroprotective Agents; D010636:Phenols; D059808:Polyphenols; D013729:Terpenes; D008550:Melatonin