title: Urokinase-type plasminogen activator and plasminogen-activator-inhibitor type 1 predict metastases in good prognosis breast cancer patients.
abstract: This retrospective analysis was designed to confirm the predictive role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type I (PAI-1) in the outcome of early stage, node-negative breast cancer patients.
  
  
  METHODS
  Node-negative patients having not received adjuvant chemotherapy, and for whom frozen samples were available, were selected.
  
  
  RESULTS
  Among the 169 patients included, 56.8% presented with uPA >3 ng/mg of proteins and/or PAI-1 >14 ng/mg of proteins. The median follow-up was 73 months. Significant correlations were found between uPA and disease-free survival (p [univariate]=0.003; p [multivariate]=0.01), and between uPA, PAI-1, and uPA plus PAI-1 and distant relapses (p=0.002). No significant correlation was found between uPA/PAI-1 and the risk of locoregional recurrence.
  
  
  CONCLUSIONS
  This study demonstrated that uPA and PAI-1 are useful predictors of distant metastases in a subset of early stage, node-negative breast cancer patients.
authors.affiliation: Département de Biologie des Tumeurs, Institut Curie, 26 rue d'Ulm, 75231 Paris Cedex, France. patricia.de-cremoux@curie.net
authors.forename: Patricia
authors.initials: P
authors.lastname: De Cremoux
authors.forename: Laure
authors.initials: L
authors.lastname: Grandin
authors.forename: Véronique
authors.initials: V
authors.lastname: Diéras
authors.forename: Alexia
authors.initials: A
authors.lastname: Savignoni
authors.forename: Armelle
authors.initials: A
authors.lastname: Degeorges
authors.forename: Rémy
authors.initials: R
authors.lastname: Salmon
authors.forename: Marc A
authors.initials: MA
authors.lastname: Bollet
authors.forename: Fabien
authors.initials: F
authors.lastname: Reyal
authors.forename: Brigitte
authors.initials: B
authors.lastname: Sigal-Zafrani
authors.forename: Anne
authors.initials: A
authors.lastname: Vincent-Salomon
authors.forename: Xavier
authors.initials: X
authors.lastname: Sastre-Garau
authors.forename: Henri
authors.initials: H
authors.lastname: Magdelénat
authors.forename: Laurent
authors.initials: L
authors.lastname: Mignot
authors.forename: Alain
authors.initials: A
authors.lastname: Fourquet
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D011379:Prognosis; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism*
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D014568:Urokinase-Type Plasminogen Activator