A new triterpenoid from Brucea javanica.
A new triterpenoid, bruceajavanin C (1), together with bruceosides A and B (2 and 3), bruceines D and E (4 and 5), yadanziosides A and G (6 and 7), (20R)-O-(3)-alpha-L-arabinopyranosylpregn-5-ene-3beta,20-diol (8), and alpha-D-glucopyranoside, (3beta, 20R)-3-hydroxypregn-5-en-20-yl (9) were isolated from the aerial parts of Brucea javanica. The structure of 1 was elucidated on the basis of 2D-NMR spectroscopic analysis. In addition, compounds 1, 3, 4, 5, and 6 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.
Liu
Jian Hua
JH
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Qin
Jiang Jiang
JJ
Jin
Hui Zi
HZ
Hu
Xiao Jia
XJ
Chen
Ming
M
Shen
Yun Heng
YH
Yan
Shi Kai
SK
Zhang
Wei Dong
WD
D000818:Animals; D032269:Brucea / Q000737:chemistry*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D035261:Plant Components, Aerial; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D008070:Lipopolysaccharides; D014315:Triterpenes; C541579:bruceajavanin C; D009569:Nitric Oxide