Merobatzelladines A and B, anti-infective tricyclic guanidines from a marine sponge Monanchora sp.
Merobatzelladines A (1) and B (2) have been isolated from a marine sponge Monanchora sp. as antibacterial constituents. Their structures including relative stereochemistry were determined by interpretation of spectral data. The absolute stereochemistry of merobatzelladine B (2) was elucidated after introduction of the fourth ring system preinstalled with a secondary hydroxyl group to which the modified Mosher method was applied. Merobatzelladines exhibit moderate anti-infective activity against a bacterium and protozoa.
Takishima
Shunsuke
S
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Ishiyama
Aki
A
Iwatsuki
Masato
M
Otoguro
Kazuhiko
K
Yamada
Haruki
H
Omura
Satoshi
S
Kobayashi
Hirotsugu
H
van Soest
Rob W M
RW
Matsunaga
Shigeki
S
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006146:Guanidines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
D000890:Anti-Infective Agents; D006146:Guanidines; D011083:Polycyclic Compounds; C544046:merobatzelladine A; C544045:merobatzelladine B