[Free circulating DNA based colorectal cancer screening from peripheral blood: the possibility of the methylated septin 9 gene marker].
DNA methylation acts in early tumorigenesis. Its detection is possible either from tissue, stool or peripheral blood. Septin 9 is a sensitive methylation marker, which has been studied in several cancers such as breast and ovarian tumors and in neurological or hematological diseases. Septin proteins have an important role from cytoskeleton organisation to development of embryonal pattern. Nowadays intensive researches are going on about the relation between the septin 9 gene hypermethylation and colorectal cancer development.
Tóth
Kinga
K
Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika, Budapest. drtothkinga@yahoo.com
Galamb
Orsolya
O
Spisák
Sándor
S
Wichmann
Barnabás
B
Sipos
Ferenc
F
Leiszter
Katalin
K
Molnár
Jeannette
J
Molnár
Béla
B
Tulassay
Zsolt
Z
D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000097:blood*; D020558:GTP Phosphohydrolases / Q000097:blood* / Q000235:genetics*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D009154:Mutation; D009336:Necrosis; D009367:Neoplasm Staging; D058112:Septins
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D020558:GTP Phosphohydrolases; C474315:SEPTIN9 protein, human; D058112:Septins