title: A prospective randomized study to assess the efficacy of rate and site of atrial pacing on long-term development of atrial fibrillation.
abstract: The Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study is a single-blinded, parallel randomized designed multicenter study in pacemaker indicated patients with paroxysmal atrial fibrillation (AF). The objective is to evaluate whether the site of atrial pacing--conventional right atrial appendage versus low atrial septal--with or without atrial overdrive pacing will influence the development of persistent AF. The study will provide a definitive answer to whether a different atrial pacing site or the use of AF suppression pacing or both can give incremental antiarrhythmic benefit when one is implanting a device for a patient with a history of paroxysmal AF.
authors.affiliation: Queen Mary Hospital, University of Hong Kong, Hong Kong. cplau@hkucc.hku.hk
authors.forename: Chu-Pak
authors.initials: CP
authors.lastname: Lau
authors.forename: Chun-Chieh
authors.initials: CC
authors.lastname: Wang
authors.forename: Tachapong
authors.initials: T
authors.lastname: Ngarmukos
authors.forename: You-Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Chi-Woon
authors.initials: CW
authors.lastname: Kong
authors.forename: Razali
authors.initials: R
authors.lastname: Omar
authors.forename: Charn
authors.initials: C
authors.lastname: Sriratanasathavorn
authors.forename: Muhammad
authors.initials: M
authors.lastname: Munawar
authors.forename: Ruth
authors.initials: R
authors.lastname: Kam
authors.forename: Kathy Lf
authors.initials: KL
authors.lastname: Lee
authors.forename: Elizabeth Oi-Yan
authors.initials: EO
authors.lastname: Lau
authors.forename: Hung-Fat
authors.initials: HF
authors.lastname: Tse
mesh_terms: D001281:Atrial Fibrillation / Q000401:mortality* / Q000517:prevention & control*; D002304:Cardiac Pacing, Artificial / Q000379:methods* / Q000401:mortality*; D006801:Humans; D038622:Internationality; D011446:Prospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome