Structural insights into RNA splicing.
Intron splicing is a fundamental biological process whereby noncoding sequences are removed from precursor RNAs. Recent work has provided new insights into the structural features and reaction mechanisms of two introns that catalyze their own splicing from precursor RNA: the group I and II introns. In addition, there is an increasing amount of structural information on the spliceosome, which is a ribonucleoprotein machine that catalyzes nuclear pre-mRNA splicing in eukaryotes. Here, we compare structures and catalytic mechanisms of self-splicing RNAs and we discuss the possible implications for spliceosomal reaction mechanisms.
Toor
Navtej
N
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.
Keating
Kevin S
KS
Pyle
Anna Marie
AM
D001483:Base Sequence; D055162:Biocatalysis; D006801:Humans; D007438:Introns / Q000235:genetics; D008670:Metals / Q000737:chemistry / Q000378:metabolism; D012313:RNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D012326:RNA Splicing; D017381:Spliceosomes / Q000378:metabolism
D008670:Metals; D012313:RNA