Immunogenicity and safety of diphtheria-tetanus vaccine in pre-adolescent and adolescent South Koreans.
This study was conducted to compare the immunogenicity and safety of diphtheria-tetanus (Td) vaccine between pre-adolescents aged 11-12 years and adolescents aged 13-18 years. A total of 277 subjects (132 pre-adolescents and 145 adolescents) participated. After vaccination, all subjects (100%) in both groups exhibited seroprotective antibody levels (> or =0.1I U/mL) against diphtheria or tetanus toxoids. Although local adverse events following vaccination were more frequently observed in the pre-adolescent group than in the adolescent group (p=0.006), these events resolved within 7 days. Our study shows Td vaccination at age 11-12 years to be immunogenic and tolerable.
Lee
Soo Young
SY
Department of Pediatrics, The Catholic University of Korea, Seoul, Republic of Korea.
Kwak
Ga Young
GY
Nam
Chan Hee
CH
Kim
Jong Hyun
JH
Hur
Jae Kun
JK
Lee
Kyung Yil
KY
Park
Joon Su
JS
Kim
Hwang Min
HM
Kang
Jin Han
JH
D000293:Adolescent; D002648:Child; D022422:Diphtheria-Tetanus Vaccine / Q000009:adverse effects / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D014611:Vaccination
D022422:Diphtheria-Tetanus Vaccine