title: Comparison of cytological features of myxopapillary ependymomas on crush preparations.
abstract: Myxopapillary ependymoma (ME) is a rare neoplasm found predominantly in the sacro-coccygeal region in adults and is characterized by its distinct epithelial and stromal components. From 1990 to April 2008, a total of 10 ME cases were recorded at our institution. Six out of 10 cases underwent frozen section examination with concomitant crush preparations, which forms the basis of this study. The clinical and cytologic findings in all six cases were reviewed. There were four males and two females. The age ranges from 15 to 36 years with a mean age of 27 years. The epithelial component of ME is strikingly similar for all six cases showing tumor cells appearing singly or in loose clusters, most with papillary branching. There was also presence of indistinct cell boundaries, tapered cytoplasmic prolongations, wispy/fragile cytoplasm, and uniform oval-to-fusiform shaped nuclei with an evenly distributed chromatin pattern. The stromal component was composed mainly of thick, metachromatic material and adenoid cystic-like areas. One case showed rosette-like structures. These aforementioned characteristics can be utilized to distinguish ME from other primary and metastatic tumors such as meningioma, adenoid cystic carcinoma, chordoma, mucinous adenocarcinoma, chondrosarcoma, and germ cell tumors.
authors.affiliation: Rush University Medical Center, Department of Pathology, Chicago, Illinois, USA. dawn_bradly@rush.edu
authors.forename: Dawn P
authors.initials: DP
authors.lastname: Bradly
authors.forename: Vijaya B
authors.initials: VB
authors.lastname: Reddy
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Cochran
authors.forename: Paolo
authors.initials: P
authors.lastname: Gattuso
mesh_terms: D000293:Adolescent; D000328:Adult; D016543:Central Nervous System Neoplasms / Q000473:pathology*; D003584:Cytological Techniques / Q000379:methods*; D004806:Ependymoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male