title: Local control of the primary tumour in metastatic neuroblastoma.
abstract: The previous studies have stressed on the importance of loco-regional control in the management of high-risk neuroblastoma. We searched the Surveillance, Epidemiology and End-Results (SEER) database for patients older than 2years with metastatic neuroblastoma who were diagnosed from 1998 to 2005. We identified 291 patients (mean age, 4.35years). The 5-year survival estimate was 53.2%+/-6.4% for patients who had complete resection of their primary tumours (n=116) and 35.7%+/-4.7% for patients who did not have complete resection (p=0.003). External-beam radiotherapy did not affect survival (p=0.79); this finding has to be taken with caution due to the study limitations.
authors.affiliation: Department of Pediatric Oncology, King Hussein Cancer Centre (KHCC), Al-Jubeiha, Amman, Jordan. isultan@khcc.jo
authors.forename: Iyad
authors.initials: I
authors.lastname: Sultan
authors.forename: Khalil
authors.initials: K
authors.lastname: Ghandour
authors.forename: Usama
authors.initials: U
authors.lastname: Al-Jumaily
authors.forename: Sameh
authors.initials: S
authors.lastname: Hashem
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodriguez-Galindo
mesh_terms: D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery*; D012042:Registries; D012186:Retroperitoneal Neoplasms / Q000532:radiotherapy / Q000601:surgery; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology