Otitis media with effusion in children.
BACKGROUND
Up to 80% of children have been affected by otitis media with effusion (OME) by the age of 4 years, but prevalence declines beyond 6 years of age. Non-purulent middle-ear infections can occur in children or adults after upper respiratory tract infection or acute otitis media. Half or more of cases resolve within 3 months and 95% within a year, but complications such as tympanic membrane perforation, tympanosclerosis, otorrhoea, and cholesteatoma can occur.


METHODS
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions to prevent OME; and of pharmacological, mechanical, and surgical interventions to treat OME? We searched: Medline, Embase, The Cochrane Library and other important databases up to March 2006. (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).


RESULTS
We found 22 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.


CONCLUSIONS
In this systematic review we present information relating to the effectiveness and safety of the following interventions: adenoidectomy, antibiotics, antihistamines, autoinflation, bottle feeding, decongestants, exposure to other children, intranasal corticosteroids, mucolytics, oral corticosteroids, passive smoking, ventilation tubes.
Williamson
Ian
I
The University of Southampton, Southampton, UK.
D000208:Acute Disease; D000900:Anti-Bacterial Agents; D002648:Child; D006801:Humans; D015994:Incidence; D063371:Myringosclerosis; D010033:Otitis Media; D010034:Otitis Media with Effusion; D018058:Tympanic Membrane Perforation
D000900:Anti-Bacterial Agents