title: Nucleotide variation in central nervous system genes among male suicide attempters.
abstract: Despite marked morbidity and mortality associated with suicidal behavior, accurate identification of individuals at risk remains elusive. The goal of this study is to identify a model based on single nucleotide polymorphisms (SNPs) that discriminates between suicide attempters and non-attempters using data mining strategies. We examined functional SNPs (n = 840) of 312 brain function and development genes using data mining techniques. Two hundred seventy-seven male psychiatric patients aged 18 years or older were recruited at a University hospital psychiatric emergency room or psychiatric short stay unit. The main outcome measure was history of suicide attempts. Three SNPs of three genes (rs10944288, HTR1E; hCV8953491, GABRP; and rs707216, ACTN2) correctly classified 67% of male suicide attempters and non-attempters (0.50 sensitivity, 0.82 specificity, positive likelihood ratio = 2.80, negative likelihood ratio = 1.64). The OR for the combined three SNPs was 4.60 (95% CI: 1.31-16.10). The model's accuracy suggests that in the future similar methodologies may generate simple genetic tests with diagnostic utility in identification of suicide attempters. This strategy may uncover new pathophysiological pathways regarding the neurobiology of suicidal acts.
authors.affiliation: Department of Psychiatry at Fundacion Jimenez Diaz Hospital, Autonoma University, Madrid, Spain. eb2452@columbia.edu
authors.forename: Enrique
authors.initials: E
authors.lastname: Baca-Garcia
authors.forename: Concepción
authors.initials: C
authors.lastname: Vaquero-Lorenzo
authors.forename: M Mercedes
authors.initials: MM
authors.lastname: Perez-Rodriguez
authors.forename: Mònica
authors.initials: M
authors.lastname: Gratacòs
authors.forename: Mònica
authors.initials: M
authors.lastname: Bayés
authors.forename: Ricardo
authors.initials: R
authors.lastname: Santiago-Mozos
authors.forename: Jose Miguel
authors.initials: JM
authors.lastname: Leiva-Murillo
authors.forename: Mario
authors.initials: M
authors.lastname: de Prado-Cumplido
authors.forename: Antonio
authors.initials: A
authors.lastname: Artes-Rodriguez
authors.forename: Antonio
authors.initials: A
authors.lastname: Ceverino
authors.forename: Carmen
authors.initials: C
authors.lastname: Diaz-Sastre
authors.forename: Pablo
authors.initials: P
authors.lastname: Fernandez-Navarro
authors.forename: Javier
authors.initials: J
authors.lastname: Costas
authors.forename: José
authors.initials: J
authors.lastname: Fernandez-Piqueras
authors.forename: Montserrat
authors.initials: M
authors.lastname: Diaz-Hernandez
authors.forename: Jose
authors.initials: J
authors.lastname: de Leon
authors.forename: Enrique
authors.initials: E
authors.lastname: Baca-Baldomero
authors.forename: Jeronimo
authors.initials: J
authors.lastname: Saiz-Ruiz
authors.forename: J John
authors.initials: JJ
authors.lastname: Mann
authors.forename: Ramin V
authors.initials: RV
authors.lastname: Parsey
authors.forename: Angel
authors.initials: A
authors.lastname: Carracedo
authors.forename: Xavier
authors.initials: X
authors.lastname: Estivill
authors.forename: Maria A
authors.initials: MA
authors.lastname: Oquendo
mesh_terms: D000328:Adult; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012680:Sensitivity and Specificity; D013406:Suicide, Attempted