title: Experimental measurement of the mechanical properties of carotid atherothrombotic plaque fibrous cap.
abstract: Eleven carotid atherothrombotic plaque samples were harvested from patients. Three samples that were highly calcified were discarded, while eight yielded results. The elastic properties of the material were estimated by fitting the measured indentation response to finite element simulations. The methodology was refined and its accuracy quantified using a synthetic rubber. The neo-Hookean form of the material model gave a good fit to the measured response of the tissue. The inferred shear modulus mu was found to be in the range 7-100 kPa, with a median value of 11 kPa. A review of published materials data showed a wide range of material properties for human atherothrombotic tissue. The effects of anisotropy and time dependency in these published results were highlighted. The present measurements were comparable to the static radial compression tests of Lee et al, 1991 [Structure-dependent dynamic behaviour of fibrous caps from human atherosclerotic plaques. Circulation 83, 1764-1770].
authors.affiliation: Department of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK.
authors.forename: S R H
authors.initials: SR
authors.lastname: Barrett
authors.forename: M P F
authors.initials: MP
authors.lastname: Sutcliffe
authors.forename: S
authors.initials: S
authors.lastname: Howarth
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Li
authors.forename: J H
authors.initials: JH
authors.lastname: Gillard
mesh_terms: D016880:Anisotropy; D001696:Biomechanical Phenomena; D002339:Carotid Arteries / Q000473:pathology / Q000503:physiopathology*; D019245:Compressive Strength; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D011312:Pressure; D013314:Stress, Mechanical; D013718:Tensile Strength; D013927:Thrombosis / Q000503:physiopathology*; D013997:Time Factors; D016474:Weight-Bearing