title: Oligopeptide-modified silicon nanowire arrays as multichannel metal ion sensors.
abstract: Semiconducting nanowires have the potential to function as highly sensitive and selective sensors for label-free detection of biological and chemical species. In this paper, we describe the preparation and applications of oligopeptide-modified single crystal silicon nanowire (SiNW) arrays as multichannel metal ion sensors. Because these SiNW arrays were fabricated by using a "top-down" process, a very high density of individually addressable SiNW (180 SiNWs grouped into 36 clusters) can be manufactured on a single chip. Furthermore, after two different SiNW clusters are modified with Pb(2+)-selective and Cu(2+)-selective oligopeptide, respectively, concentrations of Pb(2+) and Cu(2+) in aqueous solutions can be detected simultaneously and selectively in two different channels. By using the SiNW arrays, we successfully achieved a detection limit of 1 nM for Pb(2+) and 10 nM for Cu(2+), respectively. These results demonstrate the potential utility of oligopeptide-modified SiNW arrays for highly sensitive and selective chemical and biological sensing applications.
authors.affiliation: Institute of Microelectronics, A*STAR (Agency for Science, Technology, and Research), Science Park II, Singapore, Singapore.
authors.forename: Xinyan
authors.initials: X
authors.lastname: Bi
authors.forename: Ajay
authors.initials: A
authors.lastname: Agarwal
authors.forename: Kun-Lin
authors.initials: KL
authors.lastname: Yang
mesh_terms: D000327:Adsorption; D015374:Biosensing Techniques / Q000295:instrumentation*; D004563:Electrochemistry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007477:Ions; D008670:Metals / Q000032:analysis* / Q000737:chemistry; D046228:Microarray Analysis / Q000295:instrumentation*; D008839:Microelectrodes; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D009842:Oligopeptides / Q000737:chemistry*; D011485:Protein Binding; D012825:Silicon / Q000737:chemistry*; D014159:Transducers
chemical_list: D007477:Ions; D008670:Metals; D009842:Oligopeptides; D012825:Silicon