title: Efficacy and tolerance of superoxidized solution in the treatment of mild to moderate inflammatory acne. A double-blinded, placebo-controlled, parallel-group, randomized, clinical trial.
abstract: BACKGROUND
  Superoxidized solution (SOS) is an electrochemically processed aqueous solution manufactured from pure water and sodium chloride. Inflammatory skin disorders have all improved their outcomes with the use of SOS. These indications suggest that SOS could be useful in acne.
  
  
  METHODS
  A total of 89 patients were enrolled in this double blinded, clinical trial. Patients presented with 10-50 inflammatory lesions (papules and pustules) and an absence of nodulocystic lesions.
  
  
  RESULTS
  Improvement was excellent in nine patients (23%) using SOS, compared with five patients (21%) using benzoyl peroxide (BP) (p = 0.378); good in 21 patients (54%) using SOS and 12 patients (50%) using BP (p = 0.794), compared with four patients (18%) taking placebo (p = 0.001); and fair in six patients (15%) using SOS and five patients (21%) using BP (p = 0.415), compared with 12 patients taking placebo (55%) (p = 0.014). In three patients using SOS (8%) the response was poor, compared with two patients (8%) using BP (p = 0.725) and six patients (27%) taking placebo (p = 0.075). We did not need to change a dose during the study period and no systemic effect was observed.
  
  
  CONCLUSIONS
  We found that SOS is an important choice to treat inflammatory acne, comparable with benzoyl peroxide; however, a larger sample is needed.
authors.affiliation: Servicio de Dermatología, Hospital General de México OD, México. andrestiradosanchez@hotmail.com
authors.forename: Andrés
authors.initials: A
authors.lastname: Tirado-Sánchez
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Ponce-Olivera
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology*; D000293:Adolescent; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000627:therapeutic use*; D008297:Male; D019999:Pharmaceutical Solutions; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D003879:Dermatologic Agents; D019999:Pharmaceutical Solutions; C118085:superoxidized water; D006861:Hydrogen Peroxide