title: Reproducibility of MR perfusion and (1)H spectroscopy of bone marrow.
abstract: OBJECTIVE
  To determine the reproducibility of proton ((1)H) magnetic resonance (MR) spectroscopy and dynamic contrast-enhanced MR imaging in a clinical setting for the assessment of marrow fat fraction and marrow perfusion in longitudinal studies.
  
  
  METHODS
  In all, 36 subjects (17 females, 19 males, mean age 72.9 +/- 2.9 years) who underwent MR spectroscopy and/or dynamic contrast-enhanced perfusion imaging of the proximal femur were asked to return after 1 week for a repeat MR examination.
  
  
  RESULTS
  Reproducibility of (1)H MR spectroscopy in all bone areas tested was high, ranging from 0.78-0.85, with the highest reproducibility being in the femoral head and lowest in the femoral neck. Reproducibility of paired perfusion measurements ranged from 0.59 (enhancement slope femoral head) to 0.98 (enhancement maximum acetabulum). Overall reproducibility of (1)H MR spectroscopy and dynamic contrast-enhanced imaging tended to be best in areas with the highest inherent fat fraction or perfusion.
  
  
  CONCLUSIONS
  Reproducibility of (1)H MR spectroscopy or perfusion imaging is sufficiently high to warrant these techniques being applied to the longitudinal study of bone diseases.
authors.affiliation: Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong. griffith@cuhk.edu.hk
authors.forename: James F
authors.initials: JF
authors.lastname: Griffith
authors.forename: David K W
authors.initials: DK
authors.lastname: Yeung
authors.forename: Steven K K
authors.initials: SK
authors.lastname: Chow
authors.forename: Jason Chi Shun
authors.initials: JC
authors.lastname: Leung
authors.forename: Ping Chung
authors.initials: PC
authors.lastname: Leung
mesh_terms: D000368:Aged; D015519:Bone Density; D001853:Bone Marrow / Q000737:chemistry*; D003287:Contrast Media; D005260:Female; D005269:Femur; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008536:Meglumine; D009942:Organometallic Compounds; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine