[Osteomalacia and giant cell tumor: a rare case].
BACKGROUND
Oncogenic octeomalacia is an unusual and rare clinicopathologic syndrome characterized by mesenchymal tumors that apparently produce osteomalacia and biochemical abnormalities consisting of hypophosphatemia and normocalcemia.


OBJECTIVE
We have investigated the mechanism by which a giant cell tumor of bone caused biopsy-proved osteomalacia in a 50-year-old woman.


METHODS
A 50-year-old woman presented with generalized bone and pelvicrural pain, associated with fatiguability and muscle weakness. The diagnosis of osteomalacia was retained, associated with a giant cell tumor. The coexistence of giant cell tumor of bone and osteomalacia suggested the diagnosis of oncogenic osteomalacia. Resolution of the biochemical abnormalities of the syndrome after tumor resection, established this diagnosis.


CONCLUSIONS
oncogenic osteomalacia can be a form of vitamin-D-refractory osteomalacia due to altered vitamin D3 metabolism.
Sehli
Hela
H
Service de Rhumatologie, Hôpital La Rabta, Tunis, Tunisie.
Daoud
Lilia
L
Ben Mbarek
Rim
R
Ghorbel
Rim
R
Ben Abdelghani
Kaouther
K
Charfi
Hichem
H
Cheour
Ilhem
I
Tarhouni
Lamjed
L
Sellami
Slaheddine
S
D001859:Bone Neoplasms / Q000150:complications*; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D010018:Osteomalacia / Q000209:etiology* / Q000473:pathology