title: [A case of AFP-producing gastric cancer responding to the combination of systemic chemotherapy, transcatheter arterial embolization and hepatic infusion chemotherapy].
abstract: We report a case of a 64-year-old male with a-fetoprotein(AFP)-producing gastric cancer accompanied by large liver metastases and multiple lymph node metastases. The patient's serum AFP level was 42,307 ng/mL and a biopsy specimen showed AFP-positive tumor cells immunohistochemically. Systemic chemotherapy by tegafur gimeracil oteracil potassium(S-1)and local therapy for the hepatic metastases consisting of transcatheter arterial embolization (TAE)and infusion of epirubicin(EPI)to the hepatic arteries decreased the serum AFP level and reduced the gastric cancer and metastases. Due to the increase of AFP and lymph node metastases, we had to successively change the regimen to paclitaxel(PTX), a combination of cisplatin(CDDP)/irinotecan(CPT-11)and S-1. Continuous systemic chemotherapy in combination with various drugs for gastric cancer treatment followed by TAE and hepatic infusion chemotherapy for hepatic metastases proved effective. The patient survived for 3 years and 2 months.
authors.affiliation: Dept. of Gastroenterology, Matsue City Hospital.
authors.forename: Hideki
authors.initials: H
authors.lastname: Shiochi
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamada
authors.forename: Manabu
authors.initials: M
authors.lastname: Kishina
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Murawaki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Miura
authors.forename: Takane
authors.initials: T
authors.lastname: Azumi
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yuuki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Tanaka
authors.forename: Michimori
authors.initials: M
authors.lastname: Kono
authors.forename: Teiji
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Manabu
authors.initials: M
authors.lastname: Yoshida
authors.forename: Masanobu
authors.initials: M
authors.lastname: Shabana
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002404:Catheterization; D004621:Embolization, Therapeutic; D017809:Fatal Outcome; D005773:Gastroscopy; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000378:metabolism* / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D000509:alpha-Fetoproteins