title: Quantification of modulated blood oxygenation levels in single cerebral veins by investigating their MR signal decay.
abstract: The transverse magnetization of a single vein and its surrounding tissue is subject to spin dephasing caused by the local magnetic field inhomogeneity which is induced by the very same vessel. This phenomenon can be approximated and simulated by applying the model of an infinitely long and homogeneously magnetized cylinder embedded in a homogeneous tissue background. It is then possible to estimate the oxygenation level of the venous blood by fitting the simulated magnetization-time-course to the measured signal decay. In this work we demonstrate the ability of this approach to quantify the blood oxygenation level (Y) of small cerebral veins in vivo, not only under normal physiologic conditions (Y(native) = 0.5-.55) but also during induced changes of physiologic conditions which affect the cerebral venous blood oxygenation level. Changes of blood's oxygenation level induced by carbogen (5% CO2, 95%0 02) and caffeine were observed and quantified, resulting in values of Y(carbogen) = 0.7 and Y(caffeine) = 0.42, respectively. The proposed technique may ultimately help to better understand local changes in cerebral physiology during neuronal activation by quantifying blood oxygenation in veins draining active brain areas. It may also be beneficial in clinical applications where it may improve diagnosis of cerebral pathologies as well as monitoring of responses to therapy.
authors.affiliation: Division of Translational Imaging Research, Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA
authors.forename: Jan
authors.initials: J
authors.lastname: Sedlacik
authors.forename: Alexander
authors.initials: A
authors.lastname: Rauscher
authors.forename: Jürgen R
authors.initials: JR
authors.lastname: Reichenbach
mesh_terms: D001783:Blood Flow Velocity; D001810:Blood Volume; D002110:Caffeine / Q000494:pharmacology; D002550:Cerebral Veins / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D012119:Respiration / Q000187:drug effects
chemical_list: D002110:Caffeine; D010100:Oxygen