title: [Therapeutic effect of para-toluenesulfonamide on transplanted hepatocarcinoma in nude mice].
abstract: OBJECTIVE
  To study the effect of of percutaneous para-toluenesulfonamide (PTS) injection on transplanted hepatocarcinoma in nude mice.
  
  
  METHODS
  Sixty nude mice with subcutaneous transplanted hepatocarcinoma were randomized into 6 groups, namely PTS, chemotherapy, radiotherapy, PTS+chemotherapy, PTS+radiotherapy and control groups. PTS were injected into the tumor in the nude mouse models as indicated, and the tumor growth rate and survival time of the mice were recorded.
  
  
  RESULTS
  All the treatments resulted in effective arrest of the tumor growth, but the effects of PTS+chemotherapy and PTS+radiotherapy were more obvious. No significant difference in the survival time of the mice were noted between the groups.
  
  
  CONCLUSIONS
  PTS+chemotherapy and PTS+radiotherapy are safe and reliable, and produces better effects than either radiotherapy or chemotherapy alone.
authors.affiliation: Oncology Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Meng
authors.forename: Min-ying
authors.initials: MY
authors.lastname: Li
authors.forename: Wei-liang
authors.initials: WL
authors.lastname: Zhu
authors.forename: Ji-ren
authors.initials: JR
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D015552:Injections, Intralesional; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011878:Radiotherapy; D011897:Random Allocation; D013449:Sulfonamides / Q000008:administration & dosage*; D014050:Toluene / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000096926:Benzenesulfonamides
chemical_list: D013449:Sulfonamides; D014050:Toluene; C025417:4-toluenesulfonamide; D000096926:Benzenesulfonamides