Effects of electro-acupuncture on IGF-I expression in spared dorsal root ganglia and associated spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomies.
The effects of electro-acupuncture (EA) on insulin-like growth factor-I (IGF-I) expression in the spared dorsal root ganglia (DRG) and associated spinal dorsal horns were explored in cats subjected to unilateral removal of L(1)-L(5) and L(7)-S(2) DRG, sparing the L(6) DRG. Immunohistochemistry revealed the presence of IGF-I immunoreactive products in the L(6) DRG neurons and some neurons and glial cells in the spinal cord. Western blot demonstrated that the level of IGF-I was significantly up-regulated both in the spared DRG and the dorsal horns of L(3) and L(6) cord segments at both 7 and 14 days post operation following EA. The present findings demonstrated the association between neuroplasticity and IGF-I expression, suggesting the possible role of IGF-I in EA promoted spinal cord plasticity.
Dai
Ping
P
Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China.
Wang
Zhao-Jun
ZJ
Sun
Wei-wei
WW
Pang
Jiang-xia
JX
You
Chao
C
Wang
Ting-Hua
TH
D000818:Animals; D002415:Cats; D015671:Electroacupuncture; D005727:Ganglia, Spinal / Q000378:metabolism*; D015171:Ganglionectomy; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D008297:Male; D009457:Neuroglia / Q000378:metabolism; D009473:Neuronal Plasticity; D020671:Posterior Horn Cells / Q000378:metabolism*
D007334:Insulin-Like Growth Factor I