A new injectable thermogelling material: methoxy poly(ethylene glycol)-poly(sebacic acid-D,L-lactic acid)-methoxy poly(ethylene glycol) triblock co-polymer.
A novel injectable thermogelling poly(ester-anhydride) co-polymer, methoxy poly(ethylene glycol)-poly(sebacic acid-D,L-lactic acid)-methoxy poly(ethylene glycol) (mPEG-poly(SA-LA)-mPEG) triblock co-polymer, was prepared by melt-condensation polymerization. The synthesized triblock co-polymer was characterized by FT-IR and (1)H-NMR. The aqueous solutions of mPEG-poly(SA-LA)-mPEG underwent sol-gel precipitation transition when the temperature was increased from 20 to 70 degrees C, depending on the concentration of the polymer. 5-FU, as the model drug, was mixed into the gel in a low-viscous sol state at room temperature. About 63 wt% of the loaded 5-FU could be released in vitro from the gel over 72 h at 37 degrees C. Subcutaneous injection of 25 wt% mPEG-poly(SA-LA)-mPEG aqueous solution resulted in the formation of a in situ gel depot in a rat model, which sustained for longer time than that of Pluronic F-127 aqueous solution. The biodegradable thermogelling mPEG-poly(SA-LA)-mPEG triblock co-polymer is believed to be a promising candidate for drug-delivery applications.
Zhai
Yinglei
Y
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P R China.
Deng
Liandong
L
Xing
Jinfeng
J
Liu
Yu
Y
Zhang
Qiang
Q
Dong
Anjie
A
D000818:Animals; D003652:Decanoic Acids / Q000737:chemistry; D003998:Dicarboxylic Acids / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry*; D005472:Fluorouracil / Q000737:chemistry / Q000378:metabolism; D005782:Gels / Q000737:chemistry*; D007267:Injections; D019344:Lactic Acid / Q000737:chemistry; D044367:Phase Transition; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry*; D051381:Rats; D013696:Temperature
D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D004337:Drug Carriers; D005782:Gels; C541972:methoxy poly(ethylene glycol)-poly(sebacic acid-D,L-lactic acid)-methoxy poly(ethylene glycol) triblock co-polymer; D019344:Lactic Acid; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; C011107:sebacic acid; D005472:Fluorouracil