Drug-induced liver injury due to "natural products" used for weight loss: a case report.
Taking herbal-extracts to lose weight is an underestimated health hazard. Often, these products contain active agents that can cause acute liver damage. In this case report, a 22-year-old female patient, who presented with a feature of cholestatic syndrome, was so sure that the "natural products" were not dangerous that she did not inform her physicians that she had taken them, making their task that much more challenging. Clinical presentation mimicked acute cholecystitis and the patient underwent a cholecystectomy. Surgery was without any consequences and complications, although it did not completely cure the illness. She later admitted to having taken herbal remedies and this led to the correct diagnosis of phytotherapy-related hepatotoxicity and a successful therapeutic approach. The true incidence of phytotherapy-related hepatotoxicity and its pathogenic mechanisms are largely unknown. It is important to increase the awareness of both clinicians and patients about the potential dangers of herbal remedies.
Tarantino
Giovanni
G
Department of Clinical & Experimental Medicine, Federico II University Medical School, Via S. Pansini 5, Naples, Italy. tarantin@nina.it
Pezzullo
Martina Gilda
MG
di Minno
Matteo Nicola Dario
MN
Milone
Francesco
F
Pezzullo
Luigi Sossio
LS
Milone
Marco
M
Capone
Domenico
D
D019440:Anti-Obesity Agents / Q000009:adverse effects*; D028281:Chelidonium / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology; D041881:Cholecystitis, Acute / Q000209:etiology*; D005260:Female; D006801:Humans; D032502:Lycopodium / Q000009:adverse effects; D008517:Phytotherapy / Q000009:adverse effects*; D055815:Young Adult
D019440:Anti-Obesity Agents