title: What are the clinical implications of nodular gastritis? Clues from histopathology.
abstract: There is no widely accepted histopathological definition for nodular gastritis. In this study we aim to uncover the pathologic entity responsible for the nodular appearance and to find clues about the clinical implications of nodular gastritis. Antral biopsy specimens of 160 patients with nodular gastritis and 133 patients without nodular gastritis were examined by an experienced pathologist for dysplasia, foveolar hyperplasia, inflammatory activity, intraepithelial lymphocytosis, intestinal metaplasia, and lymphoid follicle/aggregate formation, and comparative analysis was performed between the two groups of patients. The presence of intraepithelial lymphocytosis was more frequent in patients with nodular gastritis (P < 0.05). There was no difference between the two groups regarding the other pathological features such as presence of dysplasia, inflammatory activity, intestinal metaplasia, lymphoid hyperplasia, and Helicobacter pylori (H. pylori) infection. Increase of intraepithelial lymphocytes may contribute to formation of macroscopical nodules in this peculiar type of gastritis. Nodular gastritis would not indicate a new therapeutic approach in addition to the current measures for Helicobacter pylori infection.
authors.affiliation: Department of Pathology, Hacettepe University Medical School, Ankara, Turkey.
authors.forename: Cenk
authors.initials: C
authors.lastname: Sokmensuer
authors.forename: Ibrahim Koral
authors.initials: IK
authors.lastname: Onal
authors.forename: Ozgur
authors.initials: O
authors.lastname: Yeniova
authors.forename: Osman
authors.initials: O
authors.lastname: Ersoy
authors.forename: Musa
authors.initials: M
authors.lastname: Aydinli
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yonem
authors.forename: Ozgur
authors.initials: O
authors.lastname: Harmanci
authors.forename: Eda Demir
authors.initials: ED
authors.lastname: Onal
authors.forename: Gulcin
authors.initials: G
authors.lastname: Altinok
authors.forename: Figen
authors.initials: F
authors.lastname: Batman
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Bayraktar
mesh_terms: D001706:Biopsy; D005260:Female; D005756:Gastritis / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D006965:Hyperplasia; D006984:Hypertrophy; D007249:Inflammation; D008218:Lymphocytosis / Q000473:pathology; D008297:Male; D008875:Middle Aged