Changes in screening, prognosis and therapy for esophageal adenocarcinoma in Barrett's esophagus.
OBJECTIVE
Significant changes in concepts of managing Barrett's esophagus have led to change in the recommendations concerning screening, surveillance, biomarkers, and therapies in this condition over the past several years. We summarize the important changes in this regard.


RESULTS
Narrow band imaging and esophageal capsule endoscopy are alternative methods to screen for Barrett's esophagus. Narrow band imaging provides clear visualization of the mucosal pit patterns and vascular patterns, which improve the diagnostic value for specialized intestinal mataplasia. Esophageal capsule endoscopy is a new potential tool that allows a direct noninvasive visualization of esophagus. Research efforts are currently directed towards risk stratification of patients and biomarkers have been developed to predict development of esophageal adenocarcinoma. Recent studies have reported that frequent loss of heterozygosity (LOH) as well as allelic imbalances in chromosomes in esophageal adenocarcinoma. Fluorescent in-situ hybridization technique, which uses fluorescently labeled DNA probes to detect chromosomal alterations in cells, obtained from cytology specimens has been developed. It showed more sensitive and specific for abnormalities than PCR based techniques. Currently, many studies support the concept of endoscopic elimination of dysplastic lesions in the esophagus by a mucosal ablation therapy. Photodynamic therapy and radiofrequency ablation are recently developed, emerging techniques.


CONCLUSIONS
Recent advances in screening; prognostication and therapy for esophageal adenocarcinoma in Barrett's esophagus have brought a significant new insight in clinical practices and will eventually ensure better patients outcomes.
Tomizawa
Yutaka
Y
Barrett's Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Wang
Kenneth K
KK
D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D001471:Barrett Esophagus / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D001707:Biopsy, Needle; D053704:Capsule Endoscopy / Q000379:methods; D017115:Catheter Ablation / Q000379:methods; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D004945:Esophagoscopy / Q000379:methods; D005260:Female; D005544:Forecasting; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008403:Mass Screening / Q000592:standards* / Q000639:trends; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D010778:Photochemotherapy / Q000379:methods; D011230:Precancerous Conditions / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D018570:Risk Assessment; D016896:Treatment Outcome