title: The reliability of fractional flow reserve measurement in patients with diabetes mellitus.
abstract: BACKGROUND
  Fractional flow reserve (FFR) is an invasive method to assess the functional significance of coronary stenoses. The value of FFR in diabetic patients is controversial because of microvascular dysfunction. The aim of this study is to investigate the effect of diabetes mellitus (DM) on FFR measurements.
  
  
  METHODS
  One hundred and twenty-one patients with an intermediate lesion who had undergone FFR measurement were included in the study. Lesion severity was determined by quantitative coronary angiography. The patients were divided into groups according to the presence (group 1) or absence (group 2) of DM. The patients were further categorized according to the degree of luminal narrowing caused by the lesion (40-50, 51-60, and >60%) and reference vessel diameter (> or = 2.8 and <2.8 mm). FFR measurements were compared in each category.
  
  
  RESULTS
  There was no difference between the FFR values of diabetic and nondiabetic patients who had coronary lesions with similar degree of luminal narrowing (0.87+/-0.08 vs. 0. 0.85+/-0.07; 0.81+/-0.08 vs. 0.82+/-0.10; 0.81+/-0.10 vs. 0.83+/-0.09, P = 0.957). In the analysis comparing FFR measurements in the categories set according to reference vessel diameter, we did not find a difference either (0.82+/-0.09 vs. 0.83+/-0.09; 0.84+/-0.09 vs. 0.82+/-0.09, P = 0.878). The DeltaFFR value, which is the difference between FFR values before and after adenosine administration, was also similar in diabetic and nondiabetic patients (8.4+/-6.0 vs. 8.4+/-5.5, P = 0.997).
  
  
  CONCLUSIONS
  The presence of DM does not have a significant impact on FFR values in coronary stenoses of intermediate severity.
authors.affiliation: Department of Cardiology, School of Medicine, Gazi University, Ankara 06500, Turkey. asifesah@yahoo.com
authors.forename: Asife
authors.initials: A
authors.lastname: Sahinarslan
authors.forename: Sinan Altan
authors.initials: SA
authors.lastname: Kocaman
authors.forename: Hilal
authors.initials: H
authors.lastname: Olgun
authors.forename: Tolga
authors.initials: T
authors.lastname: Kunak
authors.forename: Emrullah
authors.initials: E
authors.lastname: Kiziltunç
authors.forename: Murat
authors.initials: M
authors.lastname: Ozdemir
authors.forename: Timur
authors.initials: T
authors.lastname: Timurkaynak
mesh_terms: D000241:Adenosine; D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000175:diagnosis / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D000241:Adenosine