title: Wound complications after kidney transplantation in nondiabetic patients.
abstract: BACKGROUND
  Impaired wound healing represents a common operative complication after kidney transplantation. This problem seems to be affected by factors related to surgical technique, drugs, and patient/graft peculiarities.
  
  
  METHODS
  From January 2000 to December 2007, 350 consecutive kidney transplantations were performed in a population of nondiabetic patients. We evaluated the influence of various factors on impaired wound healing.
  
  
  RESULTS
  Among 350 kidney transplantation patients, we observed 54 cases (15.43%) of impaired healing of the surgical incision: 36 (10.29%) with first level and 18 (5.14%) with second level wound complications. Factors related to complications were overweight and delayed graft function. Cyclosporine and tacrolimus had similar effects. However, all patients developing second level complications showed more risk factors. In our experience, postoperative lymphocele did not occur as an unique factor but became a significant risk factor when associated with another one. Patients who did not have reconstruction of the muscle layers showed a greater incidence of incisional complications.
  
  
  CONCLUSIONS
  Impaired healing of the surgical incision more or less seriously influenced outcomes of transplanted patients. This complication was common and usually related to the presence of more than one risk factor.
authors.affiliation: General, Thoracic and Vascular Surgery Department, O.U. of General Surgery and Organ Transplantation, University of Naples "Federico II," Naples, Italy. michele.santangelo@unina.it
authors.forename: M
authors.initials: M
authors.lastname: Santangelo
authors.forename: M
authors.initials: M
authors.lastname: Clemente
authors.forename: S
authors.initials: S
authors.lastname: Spiezia
authors.forename: S
authors.initials: S
authors.lastname: Grassia
authors.forename: F
authors.initials: F
authors.lastname: Di Capua
authors.forename: C
authors.initials: C
authors.lastname: La Tessa
authors.forename: M G
authors.initials: MG
authors.lastname: Iovino
authors.forename: A
authors.initials: A
authors.lastname: Vernillo
authors.forename: M
authors.initials: M
authors.lastname: Galeotalanza
mesh_terms: D000328:Adult; D000368:Aged; D051799:Delayed Graft Function / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000503:physiopathology; D012307:Risk Factors; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult