title: Relationship between globus sensation and esophageal clearance.
abstract: CONCLUSIONS
  Videofluoroscopy (VF) in the prone position can diagnose a range of esophageal pathologies in all age groups. These correlate with globus sensation in younger and middle-aged patients in prone and supine positions. Abnormal esophageal clearance appears to be associated with globus sensation in young and middle-aged persons, but not in the elderly.
  
  
  OBJECTIVE
  To assess the correlation between globus sensation and abnormal esophageal clearance by VF in relation to body position and to investigate age-related abnormal esophageal clearance, as well as to confirm the utility of VF in diagnosing globus sensation in patients.
  
  
  METHODS
  This was a prospective study. In 72 patients with globus sensation and 33 controls, esophageal clearance was assessed by VF in the upright, supine, and prone positions, and transfer of barium through the esophagus was classified as normal, esophageal retention, esophageal reflux, or pharyngeal reflux. The detection rate of abnormal esophageal clearance was compared among all subjects by age.
  
  
  RESULTS
  In the upright position, VF detected no significant differences in the detection rate of abnormal esophageal clearance and reflux between the patients with globus sensation and controls; however, the detection rate of abnormal esophageal clearance was significantly higher in the prone than in the upright and supine positions (p<0.001), and in all positions was significantly higher among globus sensation patients (p<0.05). In the supine and prone positions, there were significantly higher detection rates of abnormal esophageal clearance in patients than in controls in the young group (p<0.05). Additionally in the prone position, there was a significantly higher detection rate of abnormal esophageal clearance and reflux in patients than in controls in the middle-aged group (p<0.05). In all positions, no significant differences were observed in the detection rate of abnormal esophageal clearance and reflux in the patients and controls in the elderly group.
authors.affiliation: Department of Otolaryngology, National Defense Medical College, Tokorozawa, Japan. jinadachi@yahoo.co.jp
authors.forename: Jin
authors.initials: J
authors.lastname: Adachi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ohmae
authors.forename: Takehiro
authors.initials: T
authors.lastname: Karaho
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tanabe
authors.forename: Daisuke
authors.initials: D
authors.lastname: Mizokami
authors.forename: Kouji
authors.initials: K
authors.lastname: Hirota
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tomifuji
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kurita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsunobu
authors.forename: Akihiro
authors.initials: A
authors.lastname: Shiotani
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001466:Barium Sulfate; D003287:Contrast Media; D003291:Conversion Disorder / Q000175:diagnosis* / Q000503:physiopathology; D015154:Esophageal Motility Disorders / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D005471:Fluoroscopy / Q000295:instrumentation*; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016684:Prone Position; D011446:Prospective Studies; D012016:Reference Values; D016683:Supine Position; D014741:Video Recording / Q000295:instrumentation*
chemical_list: D003287:Contrast Media; D001466:Barium Sulfate