title: DNA double-strand breaks in meiosis: checking their formation, processing and repair.
abstract: DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, but meiotic cells deliberately introduce them into their genome in order to initiate homologous recombination, which ensures proper homologous chromosome segregation. To minimize the risk of deleterious effects, meiotic DSB formation, processing and repair are tightly regulated in order to occur only at the right time and place. Furthermore, a highly conserved signal-transduction pathway, called meiotic recombination checkpoint, coordinates DSB repair with meiotic progression and promotes meiotic recombination.
authors.affiliation: Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, P.zza della Scienza 2, 20126 Milan, Italy. mariapia.longhese@unimib.it
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Longhese
authors.forename: Diego
authors.initials: D
authors.lastname: Bonetti
authors.forename: Ilaria
authors.initials: I
authors.lastname: Guerini
authors.forename: Nicola
authors.initials: N
authors.lastname: Manfrini
authors.forename: Michela
authors.initials: M
authors.lastname: Clerici
mesh_terms: D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D008540:Meiosis; D011995:Recombination, Genetic / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000201:enzymology / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
chemical_list: D029701:Saccharomyces cerevisiae Proteins