title: Drug-induced hepatotoxicity or drug-induced liver injury.
abstract: Drug-induced hepatotoxicity is underreported and underestimated in the United States. It is an important cause of acute liver failure. Common classes of drugs causing drug-induced hepatotoxicity include antibiotics, lipid lowering agents, oral hypoglycemics, psychotropics, antiretrovirals, acetaminophen, and complementary and alternative medications. Hepatotoxic drugs often have a signature or pattern of liver injury including patterns of liver test abnormalities, latency of symptom onset, presence or absence of immune hypersensitivity, and the course of the reaction after drug withdrawal.
authors.affiliation: Department of Medicine, University of Louisville School of Medicine, 550 South Jackson Street, Louisville, KY 40292, USA.
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Pugh
authors.forename: Ashutosh J
authors.initials: AJ
authors.lastname: Barve
authors.forename: Keith
authors.initials: K
authors.lastname: Falkner
authors.forename: Mihir
authors.initials: M
authors.lastname: Patel
authors.forename: Craig J
authors.initials: CJ
authors.lastname: McClain
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000378:metabolism; D044966:Anti-Retroviral Agents / Q000009:adverse effects* / Q000378:metabolism; D000529:Complementary Therapies / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D017114:Liver Failure, Acute / Q000139:chemically induced*; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D044966:Anti-Retroviral Agents; D011619:Psychotropic Drugs