The chemokine-binding protein M3 as a tool to understand the chemokine network in vivo.
Murine herpesvirus 68 (MHV-68) codes for a secreted chemokine-binding protein, termed M3, which interacts with a broad range of chemokines with very high affinity, inhibiting chemokine function both in vitro and in vivo. Here we describe the transgenic methodology used to study the role of M3 as an immune modulator in vivo.
Lira
Sergio A
SA
Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA.
Viejo-Borbolla
Abel
A
Shang
Limin
L
Martin
Andrea P
AP
D000818:Animals; D002465:Cell Movement / Q000187:drug effects / Q000235:genetics; D018925:Chemokines / Q000378:metabolism* / Q000494:pharmacology; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D018144:Rhadinovirus / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D018925:Chemokines; C118862:M3 protein, Murine gammaherpesvirus; D014764:Viral Proteins