title: Recent developments in the chemistry of deoxyribonucleic acid (DNA) intercalators: principles, design, synthesis, applications and trends.
abstract: In the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importance, drawbacks and challenges in this pertinent, new, and exciting research area. Additionally, some clinical applications (molecular processes, cancer therapy and others) and trends are described.
authors.affiliation: Laboratory of Medicinal and Technological Chemistry, University of Brasilia (IQ-UnB), Brasilia, DF, Brazil. brenno.ipi@gmail.com
authors.forename: Brenno A D
authors.initials: BA
authors.lastname: Neto
authors.forename: Alexandre A M
authors.initials: AA
authors.lastname: Lapis
mesh_terms: D000166:Acridines / Q000138:chemical synthesis / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000166:Acridines; D005456:Fluorescent Dyes; D007364:Intercalating Agents; D011810:Quinoxalines; D004247:DNA