title: [Influence of leptin and adiponectin on prostate cancer].
abstract: BACKGROUND
  Many studies have investigated the association between obesity, adipose tissue-derived factors (leptin and adiponectin) and prostate cancer (CaP) but the results are still inconsistent.
  
  
  METHODS
  The aim of this study was to carry out a comprehensive review of the existing evidence about the role of leptin and adiponectin in prostate carcinogenesis and to provide an overview of it.
  
  
  RESULTS
  Recent evidence suggests that leptin may play a rol in prostate cancer progression, while adiponectin may act as an "antiprostatic cancer" adipokine.
  
  
  CONCLUSIONS
  Obesity may promote the progression of established prostate cancer and and adipokines may provide a molecular mechanism whereby obesity exerts its effects on prostate tumour biology.
authors.affiliation: Metabolic and Cancer Laboratory, Faculty of Pharmacy and Biochemistry, University Juan Agustin Maza, Argentina.
authors.forename: Constanza M
authors.initials: CM
authors.lastname: Lopez Fontana
authors.forename: Maria E
authors.initials: ME
authors.lastname: Maselli Artola
authors.forename: Nicolas
authors.initials: N
authors.lastname: Di Milta Monaco
authors.forename: Gabriela M
authors.initials: GM
authors.lastname: Recalde Rincon
authors.forename: Maria C
authors.initials: MC
authors.lastname: Vanrell Rodriguez
authors.forename: Ana
authors.initials: A
authors.lastname: Uvilla Recupero
authors.forename: Diego
authors.initials: D
authors.lastname: Messina Lombino
authors.forename: Rafael F
authors.initials: RF
authors.lastname: Perez Elizalde
authors.forename: Jose Daniel
authors.initials: JD
authors.lastname: Lopez Laur
mesh_terms: D052242:Adiponectin / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000502:physiology*; D008297:Male; D011471:Prostatic Neoplasms / Q000209:etiology*
chemical_list: D052242:Adiponectin; D020738:Leptin