title: Age-dependent decreases in serum soluble interleukin-1 receptor type I (sIL-1RI) in healthy individuals: a population study of serum sIL-1RI levels in Japanese subjects.
abstract: The levels of several soluble cytokine receptors in body fluids of healthy individuals change with age. Clinical application of the measurement of the serum soluble interleukin-1 receptor type I (sIL-1RI) level depends critically on the samples used as the controls. At present, there is no information regarding the levels of serum sIL-1RI in healthy subjects. The purpose of this study is to reveal the age-related changes that occur in the serum sIL-1RIlevels of healthy individuals. We determined the serum sIL-1RI levels of healthy Japanese children using ELISA. The serum sIL-1RI level of children (0-14 years) was significantly higher than that of adults (more than 15 years) (P = 0.0138, n = 90). Thus, it is recommended that when the serum sIL-1RI level of patients is evaluated, it should be compared against age-matched controls.
authors.affiliation: Laboratory of Immunology and Microbiology, Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan. yokamoto@cis.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Mayuri
authors.initials: M
authors.lastname: Tanaka
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Miyahara
authors.forename: Mie
authors.initials: M
authors.lastname: Tanabe
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Gotoh
authors.forename: Takuhito
authors.initials: T
authors.lastname: Nagai
authors.forename: Naoya
authors.initials: N
authors.lastname: Fujita
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukui
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Masuzawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D005260:Female; D006262:Health; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D008875:Middle Aged; D053573:Receptors, Interleukin-1 Type I / Q000097:blood*; D012727:Sex Characteristics; D055815:Young Adult
chemical_list: D053573:Receptors, Interleukin-1 Type I