Facile preparation of novel peptosomes through complex self-assembly of hyperbranched polyester and polypeptide.
This work reported for the first time a facile template-free method to prepare polypeptide-based vesicles (peptosomes) through one-step complex self-assembly of carboxyl-terminated hyperbranched polyester and cationic poly-l-lysine (PLL). The preparation of such peptosomes, named complex peptosomes (CPs) here, is very simple just by mixing two kinds of polymer aqueous solutions together. The CP size can be readily controlled from nanosize to microsize through the adjustment of polymer concentration. The resulting nanosized CPs show unexpected size stability independent of a broad solution pH range, long-term storage stability, and almost no cytotoxicity and have demonstrated great potential to be used as the carriers in drug delivery.
Guo
Bo
B
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
Shi
Zengqian
Z
Yao
Yuan
Y
Zhou
Yongfeng
Y
Yan
Deyue
D
D008854:Microscopy, Electron; D010455:Peptides / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D012996:Solutions; D014867:Water
D010455:Peptides; D011091:Polyesters; D012996:Solutions; D014867:Water