title: [Serum levels of insulin-like growth factor-1 in neonates with hyperbilirubinemia].
abstract: OBJECTIVE
  Insulin-like grouth factor-1 (IGF-1) is polypetide hormone that has demonstrated effects on neural cells. Up to now, there is few reports about the relation between serum IGF-1 and brain damage in neonates with hyperbilirubinemia. This study explored the potential role of serum IGF-1 in neonatal hyperbilirubinemia.
  
  
  METHODS
  Serum levels of IGF-1 were measured using ECLIA in 57 term neonates with hyperbilirubinemia and 25 normal term neonates. Meanwhile, total serum bilirubin (TSB), unconjugated bilirubin (USB) and serum albumin (ALB) contents were measured by the automatic biochemistry analyzer and the ratio of USB/ALB (B/A) was calculated. The hyperbilirubinemia group was classified into three subgroups based on serum TSB levels: mild (221-256 micromol/L), moderate (257-342 micromol/L) and severe (>342 micromol/L). Serum TSB levels in the 25 normal neonates were less than 85 micromol/L (control group). NBNA was performed on the day of serum sample collection.
  
  
  RESULTS
  Serum IGF-1 levels in the mild, moderate and severe hyperbilirubinemia groups (39.38+/- 8.42, 30.77+/- 4.65 and 26.34+/- 2.05 ng/L, respectively) were obviously lower than those in the control group (50.16+/- 15.73 ng/L) (P< 0.01). There were significant differences among the three hyperbilirubinemia subgroups in serum IGF-1 levels (P< 0.01). Mean NBNA scores in the mild, moderate and severe hyperbilirubinemia groups (35.01+/- 2.26, 32.45+/- 2.74 and 26.77+/- 5.02, respectively) were significantly lower than those in the control group (38.24+/- 0.78) (P< 0.01). Significant differences in the NBNA scores were noted among the three hyperbilirubinemia subgroups (P< 0.01). Serum IGF-1 levels were positively correlated to NBNA scores (r=0.603, P< 0.01) and negatively correlated to the ratio of B/A (r=-0.483, P< 0.01).
  
  
  CONCLUSIONS
  Serum IGF-1 levels decreased obviously in neonates with hyperbilirubinemia and correlated to the severity of disease. IGF-1 might be associated with bilirubin-induced brain damage.
authors.affiliation: First Hospital of Lanzhou University, Lanzhou, China. lucy_yx1996@163.com
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Wei-Qi
authors.initials: WQ
authors.lastname: Yu
authors.forename: Xia
authors.initials: X
authors.lastname: Song
authors.forename: Er-Wei
authors.initials: EW
authors.lastname: Yuan
authors.forename: Huai-Ying
authors.initials: HY
authors.lastname: Li
mesh_terms: D001663:Bilirubin / Q000097:blood; D001921:Brain / Q000502:physiology; D005260:Female; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood* / Q000150:complications; D018730:Infant Behavior; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male
chemical_list: D007334:Insulin-Like Growth Factor I; D001663:Bilirubin