title: The effect of enalapril on skin flap viability is independent of angiotensin II AT1 receptors.
abstract: Random pattern skin flaps are still widely used in plastic surgery. However, necrosis in the distal portion resulting from ischemia is a serious problem, increasing the cost of treatment and hospitalization. To enhance skin flap viability, a variety of pharmacologic agents have been intensively investigated. The aim of this study was to assess the effect of enalapril (an angiotensin-converting enzyme inhibitor) and losartan (an angiotensin receptor blocker) in skin flap viability. Male rats of 200 to 250 g were used. Different doses of enalapril (5, 20, and 50 mg/kg) and losartan (5 mg/kg) were administrated 30 minutes prior to elevate the flap. Flap survival area was evaluated on the seventh postoperative day. Enalapril improved survival area in a dose-dependent manner, but losartan failed to improve survival area, which suggested that the effect of enalapril was not mediated through AT1 receptors.
authors.affiliation: Department of Physiology, Iran University of Medical Sciences, Tehran, Iran. pazoki49@gmail.com
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Pazoki-Toroudi
authors.forename: Marjan
authors.initials: M
authors.lastname: Ajami
authors.forename: Rouhollah
authors.initials: R
authors.lastname: Habibey
authors.forename: Ehsan
authors.initials: E
authors.lastname: Hajiaboli
authors.forename: Alireza
authors.initials: A
authors.lastname: Firooz
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D004656:Enalapril / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D044140:Receptor, Angiotensin, Type 1 / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D013524:Surgical Flaps / Q000098:blood supply*; D014022:Tissue Survival / Q000187:drug effects
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D044140:Receptor, Angiotensin, Type 1; D004656:Enalapril; D019808:Losartan