[Doppel protein and its effects on animal reproduction].
Doppel protein (abbreviation Dpl) is a newly recognized Glycosyl phosphatidyl inositol (GPI) anchored and highly glycosylated protein, which is similar to prion protein (PrP) in the chemical structure. The encoding gene of Dpl named PRND locates at the downstream of the prion protein gene (PRNP). These two proteins are different in physiological functions. The expression of Dpl focuses on testis tissue at the adult, and takes an important role in maintaining sperm integrality, normal fertility, and motion ability. We reviewed the biological characters, physiological functions of Dpl and its effects on male reproduction in order to provide theory guidance for the study on physiological function and male reproduction controlling.
Guan
Feng
F
College of Life Sciences, China Jiliang University, Hangzhou 310018, China. jlguanfeng@yahoo.com.cn
Shi
Guoqing
G
Pan
Lei
L
Liu
Nan
N
Liu
Shouren
S
Yang
Liguo
L
D000818:Animals; D058851:GPI-Linked Proteins; D006801:Humans; D008297:Male; D011328:Prions / Q000378:metabolism / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*; D013737:Testis / Q000254:growth & development / Q000378:metabolism*
D058851:GPI-Linked Proteins; D011328:Prions; C122036:Prnd protein, mouse