Characterization of multicomponent crystal formed between indomethacin and lidocaine.
OBJECTIVE
Crystalline complex was formed between indomethacin (IDM) and lidocaine (LDC) at molar ratio 2:1 from ethanol solution. The purpose of this study was elucidation of an interactive manner between IDM and LDC in ethanol solution and mechanism of the complex formation through solid state as well as liquid state.


METHODS
The chemical and physical nature of the complex was clearly elucidated by the alliance of powder X-ray diffractometry, differential scanning calorimetry, and infrared spectroscopy. The complex was also formed via solid-state reaction by cogrinding and heating treatment without any solvent.


RESULTS
The complexation process was estimated to be as follows: (i) mixing and contact of two components, (ii) disorder of crystalline LDC by grinding or fusion, and then (iii) crystal growth by heating. In addition, 1H-NMR coupled with microchanneled cell for synthesis monitoring revealed that a primary interactive force between IDM and LDC molecule was coulomb energy.
Umeda
Yukiko
Y
Department of Pharmacy, Nihon University School of Medicine, Itabashi Hospital, Itabashi, Tokyo, Japan.
Fukami
Toshiro
T
Furuishi
Takayuki
T
Suzuki
Toyofumi
T
Tanjoh
Katsuhisa
K
Tomono
Kazuo
K
D003460:Crystallization; D018360:Crystallography, X-Ray / Q000379:methods; D007213:Indomethacin / Q000737:chemistry* / Q000378:metabolism; D008012:Lidocaine / Q000737:chemistry* / Q000378:metabolism; D011208:Powders; D014961:X-Ray Diffraction / Q000379:methods*
D011208:Powders; D008012:Lidocaine; D007213:Indomethacin