Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection.
Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity.
Ragin
Ann B
AB
Department of Radiology, Northwestern University, Chicago, Illinois 60611-2927, USA. ann-ragin@northwestern.edu
Wu
Ying
Y
Ochs
Renee
R
Scheidegger
Rachel
R
Cohen
Bruce A
BA
McArthur
Justin C
JC
Epstein
Leon G
LG
Conant
Katherine
K
D015526:AIDS Dementia Complex / Q000097:blood / Q000473:pathology*; D000328:Adult; D001284:Atrophy / Q000473:pathology / Q000821:virology; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000473:pathology* / Q000821:virology; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D020783:Matrix Metalloproteinase 7 / Q000097:blood*; D008875:Middle Aged
D015415:Biomarkers; D020783:Matrix Metalloproteinase 7; D020781:Matrix Metalloproteinase 1