title: Nuclear trafficking and functions of endocytic proteins implicated in oncogenesis.
abstract: A subset of proteins predominantly associated with early endosomes or implicated in clathrin-mediated endocytosis can shuttle between the cytoplasm and the nucleus. Although the endocytic functions of these proteins have been extensively studied, much less effort has been expended in exploring their nuclear roles. Membrane trafficking proteins can affect signalling and proliferation and this can be achieved either at a nuclear or endocytic level. Furthermore, some proteins, such as Huntingtin interacting protein 1, are known as cancer biomarkers. This review will highlight the limits of our understanding of their nuclear functions and the relevance of this to signalling and oncogenesis.
authors.affiliation: Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge CB20RE, UK. joana.borlido@cancer.org.uk
authors.forename: Joana
authors.initials: J
authors.lastname: Borlido
authors.forename: Vincent
authors.initials: V
authors.lastname: Zecchini
authors.forename: Ian G
authors.initials: IG
authors.lastname: Mills
mesh_terms: D021581:Active Transport, Cell Nucleus; D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D033942:Adaptor Proteins, Vesicular Transport