title: Synthesis, spectroscopic characterization, X-ray structure and evaluation of binding parameters of new triorganotin(IV) dithiocarboxylates with DNA.
abstract: Three new triorganotin(IV) dithiocarboxylates (1-3) with general formula R(3)SnL, where R=C(4)H(9) (1), C(6)H(11) (2), C(6)H(5) (3) and L=4-(4-nitrophenyl)piperazine-1-carbodithioate, have been synthesized and characterized by elemental analysis, Raman, FT-IR, multinuclear NMR ((1)H, (13)C and (119)Sn) and mass spectrometry. The crystal structure of complex 3 confirmed distorted trigonal-bipyramidal geometry around Sn atom. The interaction of compounds 1-3 with DNA was investigated by cyclic voltammetry (CV) and UV-vis spectroscopy. The positive peak potential shift in CV and hypochromic effect in spectroscopy evidenced intercalative mode of interaction. The results indicate that the binding affinity varies in this sequence: 1>3>2.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Zia-ur
authors.initials: ZU
authors.lastname: Rehman
authors.forename: Afzal
authors.initials: A
authors.lastname: Shah
authors.forename: Niaz
authors.initials: N
authors.lastname: Muhammad
authors.forename: Saqib
authors.initials: S
authors.lastname: Ali
authors.forename: Rumana
authors.initials: R
authors.lastname: Qureshi
authors.forename: Auke
authors.initials: A
authors.lastname: Meetsma
authors.forename: Ian Sydney
authors.initials: IS
authors.lastname: Butler
mesh_terms: D000818:Animals; D001665:Binding Sites; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002645:Chickens; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D055664:Electrochemical Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D015394:Molecular Structure; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
chemical_list: D002264:Carboxylic Acids; D009947:Organotin Compounds; D004247:DNA