title: Extinctions in heterogeneous environments and the evolution of modularity.
abstract: Extinctions of local subpopulations are common events in nature. Here, we ask whether such extinctions can affect the design of biological networks within organisms over evolutionary timescales. We study the impact of extinction events on modularity of biological systems, a common architectural principle found on multiple scales in biology. As a model system, we use networks that evolve toward goals specified as desired input-output relationships. We use an extinction-recolonization model, in which metapopulations occupy and migrate between different localities. Each locality displays a different environmental condition (goal), but shares the same set of subgoals with other localities. We find that in the absence of extinction events, the evolved computational networks are typically highly optimal for their localities with a nonmodular structure. In contrast, when local populations go extinct from time to time, we find that the evolved networks are modular in structure. Modular circuitry is selected because of its ability to adapt rapidly to the conditions of the free niche following an extinction event. This rapid adaptation is mainly achieved through genetic recombination of modules between immigrants from neighboring local populations. This study suggests, therefore, that extinctions in heterogeneous environments promote the evolution of modular biological network structure, allowing local populations to effectively recombine their modules to recolonize niches.
authors.affiliation: Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Nadav
authors.initials: N
authors.lastname: Kashtan
authors.forename: Merav
authors.initials: M
authors.lastname: Parter
authors.forename: Erez
authors.initials: E
authors.lastname: Dekel
authors.forename: Avi E
authors.initials: AE
authors.lastname: Mayo
authors.forename: Uri
authors.initials: U
authors.lastname: Alon
mesh_terms: D000220:Adaptation, Biological; D005075:Biological Evolution; D004777:Environment; D014644:Genetic Variation; D011995:Recombination, Genetic