title: The efficacy of concurrent cisplatin and 5-flurouracil chemotherapy and radiation therapy for locally advanced cancer of the uterine cervix.
abstract: OBJECTIVE
  To evaluate the efficacy of concurrent chemoradiation (CCRT) using 5-flurouracil (5-FU) and cisplatin for locally advanced cervical cancer.
  
  
  METHODS
  We reviewed the medical records of 57 patients with locally advanced cervical cancer (stage IIB-IVA and bulky IB2-IIA tumor) who underwent the CCRT at Dong-A University Hospital from January 1997 to June 2007. The CCRT consisted of 5-FU, cisplatin and pelvic radiation. Every three weeks, 75 mg/m(2) cisplatin was administered on the first day of each cycle and 5-FU was infused at the dose of 1,000 mg/m(2)/d from the second day to the fifth day of each cycle. Radiation was administered to the pelvis at a daily dose of 1.8 Gy for five days per week until a medium accumulated dose reached to 50.4 Gy. If necessary, the radiation field was extended to include paraaortic lymph nodes. Consolidation chemotherapy was performed using 5-FU and cisplatin.
  
  
  RESULTS
  Fifty-seven patients were enrolled and the median follow-up duration was 53 months (range 7-120 months). The overall response rate was 91.5% (74% complete response and 17.5% partial response). The 5-year overall survival and 3-year progression free survival rates were 69.4% and 74.9%, respectively. During the follow-up period (median 23 months, range 7-60 months), fourteen patients were diagnosed as recurrent disease.
  
  
  CONCLUSIONS
  CCRT with 5-FU and cisplatin which is the primary treatment for patients with locally advanced cervical cancer was effective and well tolerated.
authors.affiliation: Department of Obstetrics and Gynecology, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Il Jung
authors.initials: IJ
authors.lastname: Choi
authors.forename: Moon Seok
authors.initials: MS
authors.lastname: Cha
authors.forename: Eunku Seul
authors.initials: ES
authors.lastname: Park
authors.forename: Myung Seok
authors.initials: MS
authors.lastname: Han
authors.forename: Youngmin
authors.initials: Y
authors.lastname: Choi
authors.forename: Goo Hwa
authors.initials: GH
authors.lastname: Je
authors.forename: Hyun Ho
authors.initials: HH
authors.lastname: Kim