Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.
Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge.
Ferner
Jan
J
Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
Suhartono
Marcel
M
Breitung
Sven
S
Jonker
Hendrik R A
HR
Hennig
Mirko
M
Wöhnert
Jens
J
Göbel
Michael
M
Schwalbe
Harald
H
D001665:Binding Sites; D016325:HIV Long Terminal Repeat; D008024:Ligands; D009690:Nucleic Acid Conformation; D010455:Peptides / Q000737:chemistry; D012367:RNA, Viral / Q000737:chemistry*
D008024:Ligands; D010455:Peptides; D012367:RNA, Viral