title: [Mucoid impaction of the bronchi caused by Schizophyllum commune which developed after discontinuation of itraconazole administration].
abstract: We report the case of a 75-year-old woman with mucoid impaction of the bronchi (MIB) due to Schizophyllum commune who improved with itraconazole (ITCZ) administration and relapsed after discontinuation of the drug. She improved again after readministration of ITCZ, and MIB has not recurred. This patient was not suffering from asthma and has been well without steroid administration. Reports of respiratory disorders due to S. commune have been increasing, and cases of allergic bronchopulmonary mycosis (ABPM), fungus ball, lung abscess, and pneumonia have been reported. Including this report, 12 cases of ABPM and MIB due to S. commune have been reported by Japanese authors. Treatment in these 12 cases included anti-fungal agent in 6, single steroid therapy in 3, combination therapy in 2, and bronchial toilet in 1 case. S. commune is not well recognized; however, one should suspect this fungus to be the causative pathogen when Aspergillus species are not detected or anti-Aspergillus antibody is negative.
authors.affiliation: Respiratory Medicine, Saitama Cardiovascular and Respiratory Center.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishiguro
authors.forename: Noboru
authors.initials: N
authors.lastname: Takayanagi
authors.forename: Keiji
authors.initials: K
authors.lastname: Harasaw
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshii
authors.forename: Aya
authors.initials: A
authors.lastname: Matsushita
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yoneda
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Miyahara
authors.forename: Naho
authors.initials: N
authors.lastname: Kagiyama
authors.forename: Daido
authors.initials: D
authors.lastname: Tokunaga
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Aoki
authors.forename: Hiroo
authors.initials: H
authors.lastname: Saito
authors.forename: Mikio
authors.initials: M
authors.lastname: Ubukata
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kurashima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugita
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kawabata
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kamei
mesh_terms: D000368:Aged; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D012008:Recurrence; D012567:Schizophyllum
chemical_list: D017964:Itraconazole