title: Nutrigenomic targeting of carbohydrate craving behavior: can we manage obesity and aberrant craving behaviors with neurochemical pathway manipulation by Immunological Compatible Substances (nutrients) using a Genetic Positioning System (GPS) Map?
abstract: Genetic mediated physiological processes that rely on both pharmacological and nutritional principles hold great promise for the successful therapeutic targeting of reduced carbohydrate craving, body-friendly fat loss, healthy body recomposition, and overall wellness. By integrating an assembly of scientific knowledge on inheritable characteristics and environmental mediators of gene expression, we review the relationship of genes, hormones, neurotransmitters, and nutrients as they correct unwanted weight gain coupled with unhappiness. In contrast to a simple one-locus, one-mechanism focus on pharmaceuticals alone, we hypothesize that the use of nutrigenomic treatment targeting multi-physiological neurological, immunological, and metabolic pathways will enable clinicians to intercede in the process of lipogenesis by promoting lipolysis while attenuating aberrant glucose cravings. In turn, this approach will enhance wellness in a safe and predictable manner through the use of a Genetic Positioning System (GPS) Map. The GPS Map, while presently incomplete, ultimately will serve not only as a blueprint for personalized medicine in the treatment of obesity, but also for the development of strategies for reducing many harmful addictive behaviors and promoting optimal health by using substances compatible with the body's immune system.
authors.affiliation: Department of Nutrigenomics and Personalized Medicine, LifeGen, Inc., La Jolla, CA, USA.
authors.forename: B William
authors.initials: BW
authors.lastname: Downs
authors.forename: Amanda L C
authors.initials: AL
authors.lastname: Chen
authors.forename: Thomas J H
authors.initials: TJ
authors.lastname: Chen
authors.forename: Roger L
authors.initials: RL
authors.lastname: Waite
authors.forename: Eric R
authors.initials: ER
authors.lastname: Braverman
authors.forename: Mallory
authors.initials: M
authors.lastname: Kerner
authors.forename: Dasha
authors.initials: D
authors.lastname: Braverman
authors.forename: Patrick
authors.initials: P
authors.lastname: Rhoades
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Prihoda
authors.forename: Tomas
authors.initials: T
authors.lastname: Palomo
authors.forename: Marlene
authors.initials: M
authors.lastname: Oscar-Berman
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Reinking
authors.forename: Seth H
authors.initials: SH
authors.lastname: Blum
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: DiNubile
authors.forename: H H
authors.initials: HH
authors.lastname: Liu
authors.forename: Kenneth
authors.initials: K
authors.lastname: Blum
mesh_terms: D002874:Chromosome Mapping / Q000379:methods; D004040:Dietary Carbohydrates; D005247:Feeding Behavior; D001068:Feeding and Eating Disorders / Q000235:genetics* / Q000517:prevention & control*; D018390:Gene Targeting / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009765:Obesity / Q000235:genetics* / Q000517:prevention & control*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D004040:Dietary Carbohydrates