title: Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis.
abstract: BACKGROUND
  Psoriasis is a chronic inflammatory skin disease. Among other cytokines, interleukin 22 (IL-22) has been implicated in the pathogenesis of chronic plaque psoriasis. The purpose of this study was to investigate a hypothesized association between common IL-22 gene polymorphisms and chronic plaque psoriasis.
  
  
  METHODS
  Genotypes of 10 common polymorphisms of the IL-22 gene were determined by fluorogenic 5' exonuclease assays (TaqMan) in 475 patients with chronic plaque psoriasis and 252 controls.
  
  
  RESULTS
  Two blocks of high linkage disequilibrium, formed by eight polymorphisms upstream of exon 5 (rs2227485, rs2227491, rs2046068, rs1179251, rs1012356, rs2227501, rs2227503, rs976748) and two polymorphisms in the 3' near gene region (rs1182844, rs1179246), were observed within the IL-22 gene. Neither single polymorphisms nor haplotypes were significantly associated with the presence or clinical features of chronic plaque psoriasis (P > 0.05).
  
  
  CONCLUSIONS
  Our data suggest that the investigated IL-22 gene polymorphisms are unlikely major risk factors for chronic plaque psoriasis.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weger
authors.forename: Angelika
authors.initials: A
authors.lastname: Hofer
authors.forename: Peter
authors.initials: P
authors.lastname: Wolf
authors.forename: Yosuf
authors.initials: Y
authors.lastname: El-Shabrawi
authors.forename: Wilfried
authors.initials: W
authors.lastname: Renner
authors.forename: Helmut
authors.initials: H
authors.lastname: Kerl
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Salmhofer
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D055815:Young Adult; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D000097043:Interleukin-22