Diphenylpentane skeleton as a multi-template for steroid skeleton-recognizing receptors/enzymes.
As an example of a multi-template approach, we focused on the 3,3-diphenylpentane (DPP) skeleton, which has been demonstrated to act as a steroid skeleton substitute. Various ligands for nuclear receptors (NRs), including vitamin D receptor (VDR), androgen receptor (AR) and farnesoid X receptor (FXR), and inhibitors of steroid metabolism-related enzymes, including 5alpha-reductase and HMG-CoA reductase (HMGR), have been efficiently created by introducing various substituents onto the DPP skeleton.
Hosoda
Shinnosuke
S
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Tokyo, Japan.
Matsuda
Daisuke
D
Tomoda
Hiroshi
H
Hashimoto
Yuichi
Y
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D010420:Pentanes / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D011987:Receptors, Steroid / Q000378:metabolism*; D013256:Steroids / Q000737:chemistry* / Q000378:metabolism*
C524325:3,3-diphenylpentane; D004791:Enzyme Inhibitors; D004798:Enzymes; D008024:Ligands; D010420:Pentanes; D011987:Receptors, Steroid; D013256:Steroids