title: Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection.
abstract: Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity.
authors.affiliation: Department of Radiology, Northwestern University, Chicago, Illinois 60611-2927, USA. ann-ragin@northwestern.edu
authors.forename: Ann B
authors.initials: AB
authors.lastname: Ragin
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.forename: Renee
authors.initials: R
authors.lastname: Ochs
authors.forename: Rachel
authors.initials: R
authors.lastname: Scheidegger
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Cohen
authors.forename: Justin C
authors.initials: JC
authors.lastname: McArthur
authors.forename: Leon G
authors.initials: LG
authors.lastname: Epstein
authors.forename: Katherine
authors.initials: K
authors.lastname: Conant
mesh_terms: D015526:AIDS Dementia Complex / Q000097:blood / Q000473:pathology*; D000328:Adult; D001284:Atrophy / Q000473:pathology / Q000821:virology; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000473:pathology* / Q000821:virology; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D020783:Matrix Metalloproteinase 7 / Q000097:blood*; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D020783:Matrix Metalloproteinase 7; D020781:Matrix Metalloproteinase 1