Breast cancer associated with type 1 neurofibromatosis.
The association between breast cancer and type 1 neurofibromatosis (NF1) is a rare clinical entity. We herein present the case of a 59-year-old woman, with typical clinical manifestations of NF1, who presented with a painless lump in her right breast, which she had first noticed 8 months earlier. Clinical examination and diagnostic workup were suggestive of a breast carcinoma, and a modified radical mastectomy was performed. Histopathological examination revealed a poorly differentiated invasive ductal breast carcinoma and multiple neurofibromas. The pathological staging was pT2N1a according to TNM/UICC. Delayed presentation of the patient was the result of her mistakenly identifying the breast tumor as a manifestation of NF1 neurofibromatosis.
Salemis
Nikolaos S
NS
Army General Hospital, Athens, Greece. nikos_salemis@hotmail.com
Nakos
Georgios
G
Sambaziotis
Dimitrios
D
Gourgiotis
Stavros
S
D001943:Breast Neoplasms / Q000150:complications* / Q000175:diagnosis*; D018270:Carcinoma, Ductal, Breast / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000150:complications*