A prospective randomized study to assess the efficacy of rate and site of atrial pacing on long-term development of atrial fibrillation.
The Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study is a single-blinded, parallel randomized designed multicenter study in pacemaker indicated patients with paroxysmal atrial fibrillation (AF). The objective is to evaluate whether the site of atrial pacing--conventional right atrial appendage versus low atrial septal--with or without atrial overdrive pacing will influence the development of persistent AF. The study will provide a definitive answer to whether a different atrial pacing site or the use of AF suppression pacing or both can give incremental antiarrhythmic benefit when one is implanting a device for a patient with a history of paroxysmal AF.
Lau
Chu-Pak
CP
Queen Mary Hospital, University of Hong Kong, Hong Kong. cplau@hkucc.hku.hk
Wang
Chun-Chieh
CC
Ngarmukos
Tachapong
T
Kim
You-Ho
YH
Kong
Chi-Woon
CW
Omar
Razali
R
Sriratanasathavorn
Charn
C
Munawar
Muhammad
M
Kam
Ruth
R
Lee
Kathy Lf
KL
Lau
Elizabeth Oi-Yan
EO
Tse
Hung-Fat
HF
D001281:Atrial Fibrillation / Q000401:mortality* / Q000517:prevention & control*; D002304:Cardiac Pacing, Artificial / Q000379:methods* / Q000401:mortality*; D006801:Humans; D038622:Internationality; D011446:Prospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome