title: A human PBPK/PD model to assess arsenic exposure risk through farmed tilapia consumption.
abstract: The purpose of this study was to develop a biologically based risk assessment model for human health through consumption of arsenic (As) contaminated farmed tilapia (Oreochromis mossambicus) from blackfoot disease (BFD)-endemic area in Taiwan for estimating the consumption advice. We linked a physiologically based pharmacokinetic (PBPK) and a pharmacodynamic (PD) model to account for the exposure and dose-response profiles of As in human. Risk analysis indicates that consumption of farmed tilapia poses no significant threat from As-induced lung and bladder cancers. The predicted risk-based median consumption advice was no more than 5-17 meals month(-1) (or 2-6 g day(-1)).
authors.affiliation: Department of Health Risk Management, China Medical University, Taichung, Taiwan, ROC. lingmp@mail.cmu.edu.tw
authors.forename: M-P
authors.initials: MP
authors.lastname: Ling
authors.forename: C-M
authors.initials: CM
authors.lastname: Liao
mesh_terms: D000818:Animals; D001151:Arsenic / Q000493:pharmacokinetics*; D020261:Arsenic Poisoning / Q000378:metabolism*; D002274:Carcinogens, Environmental / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D005398:Fisheries; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced / Q000378:metabolism; D008954:Models, Biological; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000139:chemically induced / Q000378:metabolism; D017210:Tilapia; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics*
chemical_list: D002274:Carcinogens, Environmental; D014874:Water Pollutants, Chemical; D001151:Arsenic