title: [Scientific evidence of the mediterranean diet effects in determining intermediate and final cardiovascular disease phenotypes].
abstract: The follow-up of the Mediterranean Diet (MD) has been associated with lower mortality and morbidity from cardiovascular diseases. However, it is important to evaluate the scientific evidence provided by published articles. Therefore, in order to analyze the literature on the overall effects of MD on intermediate and final disease phenotypes, we reviewed the findings from 30 selected experimental and observational studies. We analyzed the effect of MD on all-cause mortality, cardiovascular mortality, recurrence of cardiovascular events, lipid profile, inflammatory markers, blood pressure and fasting blood glucose levels. In general, MD was found to have beneficial effects on final and intermediate disease phenotypes. However, more randomized, controlled interventional studies on the overall effects of MD offering the highest level of scientific evidence are needed before adequate dietary recommendations concerning the primary prevention of cardiovascular disease can be given.
authors.affiliation: Departamento de Medicina Preventiva y Salud Pública, Universitat de València y CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Valencia, España. mercedes.sotos@uv.es
authors.forename: Mercedes
authors.initials: M
authors.lastname: Sotos-Prieto
authors.forename: Maria Angeles
authors.initials: MA
authors.lastname: Zulet
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D038441:Diet, Mediterranean; D006801:Humans; D007249:Inflammation; D050356:Lipid Metabolism; D010641:Phenotype