[Manipulation of NADH metabolism in industrial strains].
Nicotinamide adenine nucleotide (NADH), the key cofactor in the metabolic network, plays an essential role in biochemical reaction and physiological function of industrial strains. Manipulation of NADH availability and form is an efficient and easy way to redirect the carbon flux to the target metabolites in industrial strains. We reviewed the physiological function of NADH. Detailed strategies to manipulate NADH availability are addressed. NADH manipulation to enhance metabolic function of industrial strains was discussed and potential solutions were suggested.
Qin
Yi
Y
The Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China.
Dong
Zhiyao
Z
Liu
Liming
L
Chen
Jian
J
D001419:Bacteria / Q000378:metabolism*; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology*; D005285:Fermentation; D007218:Industrial Microbiology; D013294:Lactococcus lactis / Q000378:metabolism; D009243:NAD / Q000378:metabolism* / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013295:Streptococcus mutans / Q000378:metabolism
D009243:NAD