title: 5-Amino-2-pyridyl 1-thioglycosides in synthesis of analogs of glycosyltransferases substrates.
abstract: We present the synthesis of 1-thioglycosyl derivatives of uridine, which were designed to act as potential donor substrates for glycosyltransferases. We constructed such analogs using 5-amino-2-pyridyl 1-thioglycosides as glycosyl units which were connected to uridine via succinic linker. For preparation of the amide bonds we applied different condensation procedures.
authors.affiliation: Silesian University of Technology, Faculty of Chemistry, Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, 44-100 Gliwice, Krzywoustego 4, Poland. gabriela.pastuch@polsl.pl
authors.forename: Gabriela
authors.initials: G
authors.lastname: Pastuch-Gawolek
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Bieg
authors.forename: Wieslaw
authors.initials: W
authors.lastname: Szeja
authors.forename: Jakub
authors.initials: J
authors.lastname: Flasz
mesh_terms: D000818:Animals; D002460:Cell Line; D006692:Classical Swine Fever Virus / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016695:Glycosyltransferases / Q000737:chemistry* / Q000378:metabolism; D013379:Substrate Specificity; D013552:Swine; D013865:Thioglycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D013865:Thioglycosides; D016695:Glycosyltransferases