Bacteremia caused by an Enterococcus faecalis isolate with high-level linezolid resistance in a teenager with Crohn's disease.
Linezolid is an antibiotic used to treat highly resistant infections, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. Enterococcus faecalis bacteremia occurs in pediatric patients. We present a teenager admitted for bacteremia caused by E faecalis with a distinctive pattern of resistance to linezolid. This organism has the highest MIC to linezolid reported in the literature to date.
Lopez Marti
Maria G
MG
Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA. lopezmarti@duke.edu
Jhaveri
Ravi
R
D000081:Acetamides / Q000494:pharmacology*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis* / Q000382:microbiology; D003424:Crohn Disease / Q000150:complications*; D024881:Drug Resistance, Bacterial; D013293:Enterococcus faecalis / Q000302:isolation & purification*; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D000069349:Linezolid; D008297:Male; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D016896:Treatment Outcome; D014640:Vancomycin / Q000627:therapeutic use
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid