title: Secretory phospholipase A2 in patients with coronary artery disease.
abstract: This study investigated the correlation of sPLA2 (secretory phospholipase A2) activity with the atheromatosis extent in subjects with coronary artery disease (CAD) undergoing coronary angiography. We analyzed 123 patients, including 35 subjects with angiographically normal coronary arteries (controls), 31 with mild/moderate atheromatosis (stenosis of 30-70% of the luminal diameter in one or more coronary arteries) and 57 with severe atheromatosis (>70% stenosis). Plasma sPLA2 activity was significantly higher in subjects with severe [127.7 U/ml (102.3-162.7); p < 0.0001] and mild/moderate [112.0 U/ml (100.6-146.9); p < 0.0001] atheromatosis than in controls [19.8 U/ml (15.1-32.1)]. In a multiple logistic regression model, adjusted for age, gender, body mass index, tabagism, hypertension, sedentarism, family history for coronary artery disease, diabetes mellitus, total cholesterol, HDLc, LDLc, triglycerides, high sensitivity C-reactive protein and phospholipase A2, only sPLA2 was observed to be independently associated with severe CAD (>70% of stenosis) (p < 0.0001).
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos. 6627, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
authors.forename: Luciana Moreira
authors.initials: LM
authors.lastname: Lima
authors.forename: Maria das Graças
authors.initials: Md
authors.lastname: Carvalho
authors.forename: Cirilo Pereira
authors.initials: CP
authors.lastname: da Fonseca Neto
authors.forename: José Carlos Faria
authors.initials: JC
authors.lastname: Garcia
authors.forename: Marinez Oliveira
authors.initials: MO
authors.lastname: Sousa
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging* / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054497:Phospholipases A2, Secretory / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D054497:Phospholipases A2, Secretory