title: Tissue Resonance Interaction Method (TRIMprob) has the potential to be used alongside the recognized tests in the screening protocols for prostate cancer.
abstract: The objective of this study was to evaluate the accuracy of the magnetic induction technique with a nonlinear tunable oscillator (the Tissue Resonance Interaction Method [TRIMprob]) in the diagnosis of prostate cancer (CaP). Overall, 148 men were split into two groups (patients at risk of CaP [Group 1] and controls [Group 2]) and evaluated with the TRIMprob. Group 1 consisted of 100 patients (mean age: 63.8 +/- 7.2 years) with elevated prostate-specific antigen (>4 ng/mL) levels and/or abnormal digital rectal examination. Eleven patients (Group 2a, mean age: 59.5 +/- 7.3) with previously biopsy-proven CaP served as positive controls. In addition, 37 voluntary men (Group 2b, mean age: 39.8 +/- 10.4) with normal prostate-specific antigen and digital rectal examination without lower urinary tract symptoms served as negative controls. Non-linear resonance was analyzed at 465 MHz and a cut-off value of 40 units was detected as the resonance value for the best threshold to distinguish benign conditions from CaP after transrectal ultrasonography-guided biopsy with a standard 10-12 core technique in Group 1. Mean resonance values (+/-standard deviation) with the TRIMprob examination for patients in Groups 1 and 2b were 36.72 +/- 22.35 and 73.64 +/- 10.06, respectively, whereas for patients in Group 2a, it was 13.73 +/- 12.12 (P < 0.01). Sensitivity, specificity, positive and negative predictive values of the TRIMprob using the study cohort of Group 1 were found as 76%, 61.3%, 39.6% and 88.5%, respectively. Despite some technical limitations, the non-invasive TRIMprob examination may have a role in screening protocols for CaP.
authors.affiliation: Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Gokce
authors.forename: Oner
authors.initials: O
authors.lastname: Sanli
authors.forename: Artur
authors.initials: A
authors.lastname: Salmaslioglu
authors.forename: Atadan
authors.initials: A
authors.lastname: Tunaci
authors.forename: Cavit
authors.initials: C
authors.lastname: Ozsoy
authors.forename: Faruk
authors.initials: F
authors.lastname: Ozcan
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D004574:Electromagnetic Fields; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology*; D012680:Sensitivity and Specificity
chemical_list: D017430:Prostate-Specific Antigen