title: Programmed death-1 (PD-1) gene polymorphisms lodged in the genetic predispositions of Kawasaki Disease.
abstract: The purpose of this study is to investigate the association of programmed death-1 gene (PD-1) polymorphisms with genetic predispositions to Kawasaki disease (KD). A total of 73 patients with KD and 100 healthy controls were enrolled from 2007 to 2008. Two single nucleotide polymorphisms of the PD-1 gene, rs41386349 and rs2227981, were analyzed. Higher T allele frequency of rs41386349 was found in the patient group than the control group (p = 0.007, odds ratio (OR) = 1.9, 95% CI = 1.2-2.9). PD-1 rs2227981 polymorphism was not significant in patients with KD comparing with the control group (p = 0.4, OR = 1.2 (0.8-1.9)). Furthermore, no difference of PD-1 polymorphisms between patients with coronary artery dilatation (CAD) and those without CAD was found. Our data support the possibility that PD-1 gene polymorphism may be related with the genetic susceptibility of KD in Korean population.
authors.affiliation: Department of Pediatrics, Yonsei University, College of Medicine, 250 Seongsanno, Seodaemoon-gu, Seoul 120-752, South Korea.
authors.forename: Jin-Kyong
authors.initials: JK
authors.lastname: Chun
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Kang
authors.forename: Byung Won
authors.initials: BW
authors.lastname: Yoo
authors.forename: Jeon-Soo
authors.initials: JS
authors.lastname: Shin
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000097:blood / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000097:blood / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008213:Lymphocyte Activation; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D061026:Programmed Cell Death 1 Receptor; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D051017:Apoptosis Regulatory Proteins; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D004247:DNA