Long term survival in anti-Hu associated adult neuroblastoma.
We report on a young lady suffering from adult neuroblastoma and anti-Hu associated paraneoplastic encephalomyelitis (PEM) with a tumour free survival of nine years up to now. Treatment included tumour surgery, radiation, high dose chemotherapy, and stem cell transplantation. Serological testing demonstrated a marked decline in anti-Hu antibody titres under therapy, and subsequent disappearance of the antibody 31 months after second tumour resection.
Jarius
Sven
S
Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany.
Arnold
Stephan
S
Linke
Rainer
R
Noachtar
Soheyl
S
Schlemmer
Marcus
M
Issels
Rolf
R
Voltz
Raymond
R
D000914:Antibodies, Viral / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D020274:Autoimmune Diseases of the Nervous System / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology; D003131:Combined Modality Therapy; D003951:Diagnostic Errors; D051959:ELAV Proteins / Q000276:immunology*; D005260:Female; D005729:Ganglioneuroma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D006979:Hyperthermia, Induced; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D022542:Measles-Mumps-Rubella Vaccine / Q000276:immunology; D009103:Multiple Sclerosis / Q000175:diagnosis; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D009447:Neuroblastoma / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D009896:Optic Atrophy / Q000175:diagnosis / Q000209:etiology; D010220:Para-Aortic Bodies / Q000473:pathology*; D020361:Paraneoplastic Syndromes, Nervous System / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology; D036102:Peripheral Blood Stem Cell Transplantation; D011877:Radionuclide Imaging; D018714:Radiotherapy, Adjuvant; D012186:Retroperitoneal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D017741:Survivors; D016176:T-Lymphocyte Subsets / Q000276:immunology; D055815:Young Adult
D000914:Antibodies, Viral; D001323:Autoantibodies; D001324:Autoantigens; D051959:ELAV Proteins; D022542:Measles-Mumps-Rubella Vaccine