Serum antimüllerian hormone is not predictive of oocyte quality in vitro fertilization.
OBJECTIVE
The assessment of the ovarian reserve is mandatory in women undergoing assisted reproduction. Antimüllerian hormone (AMH) produced by granulosa cells from preantral and early antral follicles, is a promising indicator of ovarian reserve. However, few studies have evaluated the predictive value of AMH on oocyte quality.


METHODS
A retrospective study was undertaken at the Bretonneau University Hospital of Tours. A total of 559 women undergoing in vitro fertilization treatment between January 2007 and December 2007 were included in the study. Serum AMH levels were determined by using an ultrasensitive ELISA test. Total number of oocytes, rate of mature oocytes, fertilization rate, embryo quality and clinical pregnancy rate were recorded.


RESULTS
Serum AMH was significantly lower in groups of patients with few oocytes collected. However, serum AMH was not predictive of nuclear maturity of oocytes, fertilization rate and quality of early embryos. Additionally, low levels of AMH do not preclude clinical pregnancy, in in vitro fertilization.


CONCLUSIONS
At the moment, serum AMH is a relatively predictive indicator of the ovarian reserve, in terms of quantity but not in terms of quality. Moreover, it is still not possible to determine serum AMH cut-off value to predict clinical pregnancy in IVF programmes.
Guerif
F
F
Service de médecine et biologie de la reproduction, CHRU Bretonneau, 2, boulevard Tonnellé, 37044 Tours, France. guerif@med.univ-tours.fr
Lemseffer
M
M
Couet
M -L
M-
Gervereau
O
O
Ract
V
V
Royère
D
D
D000328:Adult; D000375:Aging / Q000502:physiology; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D005318:Fetal Heart / Q000502:physiology; D006801:Humans; D008297:Male; D009865:Oocytes / Q000502:physiology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data
D054304:Anti-Mullerian Hormone