title: [The system theory of aging: methodological principles, basic tenets and applications].
abstract: The paper deals with the system theory of aging constructed on the basis of present-day scientific methodology--the system approach. The fundamental cause for aging is discrete existence of individual life forms, i.e. living organisms which, from the thermodynamic point of view, are not completely open systems. The primary aging process (build-up of chaos and system disintegration of aging organism) obeys the second law of thermodynamics or the law of entropy increase in individual partly open systems. In living organisms the law is exhibited as synergy of four main aging mechanisms: system "pollution" of organism, loss of non-regenerative elements, accumulation of damages and deformations, generation of variability on all levels, and negative changes in regulation processes and consequent degradation of the organism systematic character. These are the general aging mechanisms; however, the regulatory mechanisms may be important equally for organism aging and search for ways to prolong active life.
authors.forename: V N
authors.initials: VN
authors.lastname: Krut'ko
authors.forename: V I
authors.initials: VI
authors.lastname: Dontsov
authors.forename: O V
authors.initials: OV
authors.lastname: Zakhar'iashcheva
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D008962:Models, Theoretical; D013598:Systems Theory