Fetal heart rate tracing patterns associated with congenital hypothyroidism.
OBJECTIVE
This study was undertaken to determine fetal heart rate (FHR) tracing patterns associated with congenital hypothyroidism.


METHODS
FHR patterns of 59 women whose babies were diagnosed with congenital hypothyroidism were retrospectively compared with tracings of 78 of their siblings. Tracings were interpreted during the first stage of labor. Multivariable analysis was used to control for confounders.


RESULTS
Neonates with congenital hypothyroidism had significantly higher rates of reduced variability in FHR tracing patterns as compared with those without congenital hypothyroidism (49.2% vs 3.8%; odds ratio, 24.1; 95% confidence interval, 6.8-85.3; P < .001). No significant differences were noted between the groups regarding decelerations or baseline abnormalities. The significant association between congenital hypothyroidism and reduced variability persisted after controlling for confounders such as treatment with pethidine, MgSO4, and gestational age (odds ratio, 14.1; 95% confidence interval, 1.1-190.7; P = .046).


CONCLUSIONS
Congenital hypothyroidism is significantly and independently associated with reduced variability in FHR tracing patterns.
Shoham
Iris
I
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Aricha-Tamir
Barak
B
Weintraub
Adi Y
AY
Mazor
Moshe
M
Wiznitzer
Arnon
A
Holcberg
Gershon
G
Sheiner
Eyal
E
D015148:Cardiotocography; D016022:Case-Control Studies; D015897:Comorbidity; D003409:Congenital Hypothyroidism / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D006340:Heart Rate, Fetal / Q000502:physiology*; D006801:Humans; D007747:Labor Stage, First / Q000502:physiology*; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies