title: Comorbidities and bleeding pattern in elderly haemophilia A patients.
abstract: The increasing numbers of comorbidities related to higher age and their treatment constitute a challenge in the treatment of haemophiliacs. Comparing prevalences of morbidities in the elderly haemophilia A population (n = 29) and the general elderly population of Germany reveals some differences. HCV infections are more frequent in the elderly haemophilia population (69% vs. 0.6%). Prevalence of cancer was five times higher than in the age matched general population (28% vs. 5.2%). Cardiac diseases seem to be less frequent although the prevalences of cardiovascular risk factors like hypertension, diabetes, and body mass index (BMI) >25 do not differ in comparison to the general population. A reduction of bleeding symptoms or dosage of FVIII could not be observed. There is a tendency of increasing bleeding symptoms with increasing age of the patients due to more frequent spontaneous joint bleedings, malignancies or treatment with phenprocoumon or ASA. In consequence, FVIII dosage had to be increased in eight patients (28%). Our patient population at the age >60 years is very small and no statistical evidence can be shown, therefore appropriate treatment of elderly haemophiliacs needs further evaluation in multicentre studies with sufficient patient numbers.
authors.affiliation: Medical Clinic III, Institute of Transfusion Medicine, Goethe University Hospital, Theodor-Stern-Kai 7, Frankfurt D-60590, Germany. wolfgang.miesbach@kgu.de
authors.forename: W
authors.initials: W
authors.lastname: Miesbach
authors.forename: S
authors.initials: S
authors.lastname: Alesci
authors.forename: S
authors.initials: S
authors.lastname: Krekeler
authors.forename: E
authors.initials: E
authors.lastname: Seifried
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D004812:Epidemiologic Methods; D005169:Factor VIII / Q000627:therapeutic use; D005858:Germany / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology*; D006395:Hemarthrosis / Q000453:epidemiology*; D006467:Hemophilia A / Q000453:epidemiology*; D006526:Hepatitis C / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005169:Factor VIII