title: Outcome of oral dysplasia: a retrospective hospital-based study of 207 patients with a long follow-up.
abstract: The aim of this retrospective hospital-based study was to review and evaluate the long-term outcome of patients with oral epithelial dysplasia (OED), with or without surgical intervention, to identify factors affecting clinical course and malignant evolution. Patients with a follow-up of at least 12 months were included. Data collected were statistically analyzed. The mean age was 63.58 years for women (n = 100) and 64.17 years for men (n = 107). One hundred and thirty-five of the patients had lesions with histopathological features of mild OED, 50 had moderate OED and 22 had severe OED. Gender and risk factors seemed not to be related with the development of OED. One hundred and thirty-three patients underwent active treatment. During the period considered, 39.4% of the 207 lesions disappeared; 19.66% remained stable and 33.7% of the total cases showed a new dysplastic event after treatment. Fifteen (7.24%) out of 207 developed a squamous cell carcinoma during follow-up. Our data showed that speckled lesions are more often associated with high histological grade. The risk of malignant development does not seem to be predictable. Surrounded by the limitations of the retrospective designs, we have showed that there is no eminent benefit of surgical intervention of OED in preventing recurrences and malignant development.
authors.affiliation: Division of Otorhinolaryngology, Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, University of Turin, Turin, Italy. paolo.arduino@gmail.com
authors.forename: Paolo G
authors.initials: PG
authors.lastname: Arduino
authors.forename: Antonio
authors.initials: A
authors.lastname: Surace
authors.forename: Mario
authors.initials: M
authors.lastname: Carbone
authors.forename: Alessandra
authors.initials: A
authors.lastname: Elia
authors.forename: Gianluca
authors.initials: G
authors.lastname: Massolini
authors.forename: Sergio
authors.initials: S
authors.lastname: Gandolfo
authors.forename: Roberto
authors.initials: R
authors.lastname: Broccoletti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003452:Cryosurgery; D004848:Epithelium / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000473:pathology / Q000601:surgery; D009061:Mouth Mucosa / Q000473:pathology* / Q000601:surgery; D009062:Mouth Neoplasms / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery; D012008:Recurrence; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D014062:Tongue Neoplasms / Q000473:pathology; D016896:Treatment Outcome