title: Drug interactions and the evolution of antibiotic resistance.
abstract: Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as well as to uncover mechanisms of drug action. Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Yeh
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Hegreness
authors.forename: Aviva Presser
authors.initials: AP
authors.lastname: Aiden
authors.forename: Roy
authors.initials: R
authors.lastname: Kishony
mesh_terms: D004336:Drug Antagonism; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D008962:Models, Theoretical; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology