title: Presentation and survival of patients with AIDS-related Kaposi's sarcoma in Jos, Nigeria.
abstract: AIDS-related Kaposi's sarcoma (AIDS-KS) remains a significant cause of morbidity and mortality. We describe the pattern of presentation and survival in Jos, Nigeria. We identified 48 HIV-positive patients with AIDS-KS and matched them for age and sex with an equal number of HIV-positive patients without AIDS-KS. We compared their clinical, immunological, virological characteristics and survival. They were similar in age and body mass index profile but patients with AIDS-KS had more tuberculosis co-infection (P, 0.02), lower median CD4 count (P, 0.003) and higher mortality (P, 0.002). Surprisingly, patients with AIDS-KS had lower levels of median viral load (29,347 copies/mL) compared with controls (80,533 copies/mL). We recommend specific AIDS-KS therapy in addition to highly active antiretroviral therapy in order to improve survival.
authors.affiliation: AIDS Prevention Initiative Nigeria (APIN) Centre, Jos University Teaching Hospital, Jos, Plateau State, Nigeria. ellagaba@yahoo.com
authors.forename: P A
authors.initials: PA
authors.lastname: Agaba
authors.forename: H M
authors.initials: HM
authors.lastname: Sule
authors.forename: R O
authors.initials: RO
authors.lastname: Ojoh
authors.forename: Z
authors.initials: Z
authors.lastname: Hassan
authors.forename: L
authors.initials: L
authors.lastname: Apena
authors.forename: M A
authors.initials: MA
authors.lastname: Mu'azu
authors.forename: B
authors.initials: B
authors.lastname: Badung
authors.forename: O O
authors.initials: OO
authors.lastname: Agbaji
authors.forename: J A
authors.initials: JA
authors.lastname: Idoko
authors.forename: P
authors.initials: P
authors.lastname: Kanki
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000401:mortality* / Q000503:physiopathology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality*; D006801:Humans; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D012514:Sarcoma, Kaposi / Q000150:complications / Q000453:epidemiology / Q000401:mortality* / Q000503:physiopathology; D016019:Survival Analysis; D015996:Survival Rate