title: Locked nucleic acid as a novel class of therapeutic agents.
abstract: Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excellent specificity toward complementary RNA and DNA oligonucleotides. The remarkable properties of LNA have led to applications within various gene silencing strategies both in vitro and in vivo. In the present review, we highlight the uses of LNA for regulation of gene expression with emphasis on RNA targeting.
authors.affiliation: Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Odense, Denmark.
authors.forename: Rakesh N
authors.initials: RN
authors.lastname: Veedu
authors.forename: Jesper
authors.initials: J
authors.lastname: Wengel
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D009841:Oligonucleotides / Q000737:chemistry / Q000235:genetics* / Q000627:therapeutic use*; D016376:Oligonucleotides, Antisense / Q000235:genetics; D012313:RNA / Q000235:genetics
chemical_list: D052157:Aptamers, Nucleotide; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; C477371:locked nucleic acid; D012313:RNA