title: [Metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces].
abstract: OBJECTIVE
  To study the metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces.
  
  
  METHODS
  The urine and feces of rats were collected at different times after orally administration of total flavonoids from Semen Ziziphi Spinosae, disposed by HP-20 macroporous resin, and then detected by both HPLC and LC-MSn methods.
  
  
  RESULTS
  Two main proto-drugs, spinosin and 6'"-feruloylspinosin, along with a metabolite, swertish (M1), are detected in both urine and feces of rat.
  
  
  CONCLUSIONS
  Flavonoids of Semen Ziziphi Spinosae are excreted in urine and feces mainly in form of proto-drug, while little in form of metabolites, such as swertish.
authors.affiliation: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Centre, Beijing 100191, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiang
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Yuying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Qingying
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry; D005419:Flavonoids / Q000032:analysis*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012661:Semen / Q000737:chemistry; D014556:Urine / Q000737:chemistry*
chemical_list: D005419:Flavonoids; C055669:spinosin