title: [Changes in oral microflora in patients with recurrent oral ulcers].
abstract: OBJECTIVE
  To investigate the correlation between the changes in oral microflora and recurrent oral ulcers (ROU).
  
  
  METHODS
  Salivary sample were collected from ROU patients with oral ulcers (group T) and those with ulcer healing (group C) as well as from ROU-free individuals (group N). The quantity of 3 common bacteria (Streptococcus sp., Veillonella sp., and Neisseria sp.) in the salivary samples was detected and compared between the 3 groups.
  
  
  RESULTS
  The quantities of Streptococcus sp. (7.30-/+0.89 copies/ml) and Veillonella sp. (8.29-/+0.77 copies/ml) in group T were significantly lower than those in group N (8.15-/+0.55 and 8.93-/+0.76 copies/ml, respectively, P<0.01), but similar with those in group C. The quantity of Streptococcus sp. (7.51-/+0.81 copies/ml) in group C was significantly lower than that in group N (8.15-/+0.55 copies/ml, P<0.01), but the quantity of Veillonella sp. was similar between the two groups. No significant difference were found in the quantity of Neisseria sp. between the 3 groups.
  
  
  CONCLUSIONS
  The quantity of oral microflora differs significantly between patients with recurrent oral ulcers and normal individuals, suggesting a possible correlation between oral microfora and recurrent oral ulcers.
authors.affiliation: Department of Pathology, Southern Medical University, Guangzhou 510515, China. setbobo@126.com
authors.forename: Jian-Zhang
authors.initials: JZ
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
mesh_terms: D000328:Adult; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000382:microbiology; D009343:Neisseria / Q000302:isolation & purification; D012463:Saliva / Q000382:microbiology*; D013281:Stomatitis, Aphthous / Q000382:microbiology*; D013291:Streptococcus / Q000302:isolation & purification*; D014678:Veillonella / Q000302:isolation & purification*