title: Valvular involvement in patients with rheumatoid arthritis.
abstract: BACKGROUND
  Although pericarditis is the most commonly recognized cardiac lesion in Rheumatoid Arthritis (RA), this disease affects all the three cardiac layers.
  
  
  OBJECTIVE
  To study valvular lesions in RA, trying to correlate them with other clinical variables, auto antibodies and functional class.
  
  
  METHODS
  One hundred twenty two controls and 184 patients with RA without cardiac symptoms were studied using bidimensional echocardiography. We also studied smoking habits, age and disease duration, rheumatoid factor, antinuclear antibody, anticardiolipin antibodies, rheumatoid nodules and functional class in RA patients.
  
  
  RESULTS
  We found that 28 RA patients (15.2%) had valvular lesions and that the aortic valve was the most affected. Valvular lesions were more common in patients with disease duration longer than 15 years (p=0.013). No association was found between valvular lesions and sex, age, tobacco exposure, rheumatoid factor positivity, presence of antinuclear antibodies, rheumatoid nodules, anticardiolipin antibodies or functional class.
  
  
  CONCLUSIONS
  A small part of RA patients had asymptomatic valvular lesions which occurred more frequently in patients with long disease duration.
authors.affiliation: Serviço de Reumatologia do Hospital Universitário Evangélico de Curitiba - PR - Brasil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Beckhauser
authors.forename: Liz
authors.initials: L
authors.lastname: Vallin
authors.forename: Claudine J
authors.initials: CJ
authors.lastname: Burkievcz
authors.forename: Sonia
authors.initials: S
authors.lastname: Perreto
authors.forename: Marilia Barreto
authors.initials: MB
authors.lastname: Silva
authors.forename: Thelma L
authors.initials: TL
authors.lastname: Skare
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications*; D005260:Female; D006349:Heart Valve Diseases / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult