Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies.
Spondyloarthropathies (SpA) are commonly observed extra-intestinal manifestations of both Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel diseases (IBD). However, the immunological link between these two clinical entities is still poorly understood. Several lines of evidence indicate that SpA may originate from the relocation to the joints of the immune process primarily induced in the gut. The transfer of the intestinal inflammatory process into the joints implicates that immune cells activated in the gut-draining lymph nodes can localize, at a certain point of the intestinal disease, either into the gut or into the joints. This is indicated by the overlapping expression of adhesion molecules observed on the surface of intestinal and synovial endothelial cells during inflammation. Moreover bacterial antigens and HLA-B27 expression may be implicated in the reactivation of T cells at the articular level. Finally, accumulating evidence indicates that a T helper 17 cell-mediated immune response may contribute to IBD and IBD-related SpA with a crucial role played by tumor necrosis factor-alpha in CD and to a lesser extent in UC.
Fantini
Massimo-C
MC
Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy. m.fantini@med.uniroma2.it
Pallone
Francesco
F
Monteleone
Giovanni
G
D000818:Animals; D000941:Antigens / Q000737:chemistry / Q000276:immunology; D002465:Cell Movement / Q000502:physiology; D002986:Clinical Trials as Topic; D015796:HLA-B27 Antigen / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D018716:Molecular Mimicry; D016201:Receptors, Lymphocyte Homing / Q000276:immunology; D025242:Spondylarthropathies / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D015796:HLA-B27 Antigen; D007166:Immunosuppressive Agents; D016201:Receptors, Lymphocyte Homing