title: Association between prehypertension and clustering of cardiovascular disease risk factors among Chinese adults.
abstract: OBJECTIVE
  We aimed to estimate the association between prehypertension (PHT) and clustering of cardiovascular disease (CVD) risk factors among Chinese adults.
  
  
  METHODS
  A cross-sectional survey in a nationally representative sample of 15,540 Chinese adults aged 35-74 years was conducted during 2000-2001.
  
  
  RESULTS
  Overall, 79.4%, 40.0%, and 11.0% of Chinese adults with PHT (120-139/80-89 mm Hg) had >or=1, >or=2, and >or=3 modifiable CVD risk factors (dyslipidemia, impaired fasting glucose/diabetes, cigarette smoking, and overweight/obesity), respectively. The adjusted odds ratio (95% confidence interval, CI) of having >or=1, >or=2, and >or=3 CVD risk factors was 1.41 (1.24-1.61), 1.45 (1.30-1.61), and 1.96 (1.67-2.29), respectively, for adults with PHT compared with those with optimal blood pressure by multivariate models. Moreover, population attributable risk percent of having >or=1, >or=2, and >or=3 CVD risk factors was 16.7%, 18.0%, and 31.9%, respectively, for adults with PHT. Furthermore, among adults with PHT, higher prevalence, adjusted odds ratios, and population attributable risk percent of having >or=1, >or=2, and >or=3 CVD risk factors were more likely to be found among people with high normal blood pressure (130-139/85-89 mm Hg) compared with their counterparts with normal blood pressure (120-129/80-84 mm Hg).
  
  
  CONCLUSIONS
  Clustering of CVD risk factors is common among Chinese adults with PHT, especially with high normal blood pressure. Global lifestyle modification would be a very important nonpharmaceutical therapy to reduce the increasing burden of CVD in China.
authors.affiliation: Department of Evidence-Based Medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Dahai
authors.initials: D
authors.lastname: Yu
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Huang
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Hu
authors.forename: Jichun
authors.initials: J
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
authors.forename: Jianxin
authors.initials: J
authors.lastname: Li
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D048909:Diabetes Complications; D050171:Dyslipidemias / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D011159:Population Surveillance; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects