title: In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates.
abstract: Glutathione reductase (GR), is responsible for the existence of GSH molecule, a crucial antioxidant against oxidative stress reagents. The antimalarial activities of some redox active compounds are attributed to their inhibition of antioxidant flavoenzyme glutathione reductase, and inhibitors are therefore expected to be useful for the treatment of malaria. Twelve organic nitrate derivatives were synthesized and treated with human erythrocyte GR. The molecules were identified as strong GR inhibitors and novel antimalaria candidates.
authors.affiliation: Atatürk University, Faculty of Science, Department of Chemistry, Erzurum, Turkey. senturkm36@gmail.com
authors.forename: Murat
authors.initials: M
authors.lastname: Sentürk
authors.forename: Oktay
authors.initials: O
authors.lastname: Talaz
authors.forename: Deniz
authors.initials: D
authors.lastname: Ekinci
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Cavdar
authors.forename: Omer Irfan
authors.initials: OI
authors.lastname: Küfrevioğlu
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004912:Erythrocytes / Q000201:enzymology*; D005980:Glutathione Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D009566:Nitrates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D004791:Enzyme Inhibitors; D009566:Nitrates; D005980:Glutathione Reductase