title: Gene diversity and biochemical markers among some Muslim populations of Uttar Pradesh.
abstract: A sample of 312 individuals belonging to Sheikh (80), Pathan (54), Ansari (82), Syed (33), Saifi (33) and Hindu Bania (30) populations were surveyed for four protein and three enzyme loci comprising 12 alleles. The markers used were protein (transferrin, haptoglobin, haemoglobin) and enzyme (lactate dehydrogenase, phosphogluconate dehydrogenase, adenylate kinase). Except caeruloplasmin, variants were found among all loci, though no rare variant appears. The populations show genetic equilibrium for all of the loci. Our gene frequencies show some difference from earlier studies for Muslims in general, there being no biradari wise study among Sunni Muslims earlier done anywhere in India or abroad. Heterozygosity ranged from 0.0123 to 0.1994 (Sheikh), 0.0182 to 0.2046 (Pathan), 0.0239 to 0.1844 (Ansari), 0.0587 to 0.3966 (Syed), 0 to 0.3909 (Bania); the average DST and GST values for the seven marker loci were 0.001032 and 0.00879, respectively. The results are discussed. The gene frequency study shows closer relationship of Ansaris and Saifis with native Hindu Banias, and may reflect on their probable conversion in the not remote past.
authors.affiliation: Human Genetics and Toxicology Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh-202 002, (U.P), India. afzal1235@rediffmail.com
authors.forename: Mohammad
authors.initials: M
authors.lastname: Afzal
authors.forename: Gulshan
authors.initials: G
authors.lastname: Ara
authors.forename: Yasir Hasan
authors.initials: YH
authors.lastname: Siddique
authors.forename: Tanveer
authors.initials: T
authors.lastname: Beg
mesh_terms: D000263:Adenylate Kinase / Q000235:genetics; D000483:Alleles; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006580:Genetic Carrier Screening; D005819:Genetic Markers / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D006242:Haptoglobins / Q000235:genetics; D006454:Hemoglobins / Q000235:genetics; D006801:Humans; D007194:India; D007514:Islam; D007770:L-Lactate Dehydrogenase / Q000235:genetics; D008297:Male; D010734:Phosphogluconate Dehydrogenase / Q000235:genetics; D014168:Transferrin / Q000235:genetics
chemical_list: D005819:Genetic Markers; D006242:Haptoglobins; D006454:Hemoglobins; D014168:Transferrin; D007770:L-Lactate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D000263:Adenylate Kinase