title: Solitary duodenal hamartomatous polyp with malignant transformation: report of a case.
abstract: A solitary duodenal hamartomatous polyp is rare and it is considered to be either a variant of Peutz-Jeghers syndrome (PJS) or a separate entity. Patients do not have cutaneous manifestations and have only one hamartomatous polyp. The presentation is nonspecific and it resembles common conditions, such as a peptic ulcer disease. Most are incidentally diagnosed during endoscopy for other indications. Malignant transformation has been reported. This report describes the case of a 46-year-old man who presented with chronic intermittent abdominal pain. The initial endoscopy showed an abnormal twisting of the duodenum with a dilated duodenum. He was later diagnosed to have a solitary duodenal hamartomatous polyp with malignant transformation, which was treated by surgery. A review of the literature on the pertinent cases of this type of lesion is also presented.
authors.affiliation: Gastroenterology Unit, Department of Medicine, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, BA 1710, Brunei Darussalam.
authors.forename: Aza Zetty Feroena
authors.initials: AZ
authors.lastname: Jamaludin
authors.forename: Pemasari Upali
authors.initials: PU
authors.lastname: Telisinghe
authors.forename: Samuel Kai San
authors.initials: SK
authors.lastname: Yapp
authors.forename: Vui Heng
authors.initials: VH
authors.lastname: Chong
mesh_terms: D002471:Cell Transformation, Neoplastic; D003937:Diagnosis, Differential; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006222:Hamartoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010580:Peutz-Jeghers Syndrome / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery