Progestogen treatments for cycle management in a sheep model of assisted conception affect the growth patterns, the expression of luteinizing hormone receptors, and the progesterone secretion of induced corpora lutea.
OBJECTIVE
To determine, in a sheep model, the effect of a short-term progestative treatment on growth dynamics and functionality of induced corpora lutea.


METHODS
Observational, model study.


METHODS
Public university.


METHODS
Sixty adult female sheep.


METHODS
Synchronization and induction of ovulation with progestogens and prostaglandin analogues; ovarian ultrasonography, blood sampling, and ovariectomy.


METHODS
Determination of pituitary function and morphologic characteristics, expression of luteinizing hormone (LH) receptors, and progesterone secretion of corpora lutea.


RESULTS
The use of progestative pretreatments for assisted conception affect the growth patterns, the expression of LH receptors, and the progesterone secretion of induced corpora lutea.


CONCLUSIONS
The current study indicates, in a sheep model, the existence of deleterious effects from progestogens on functionality of induced corpora lutea.
Letelier
Claudia
C
Escuela de Graduados, Universidad Austral de Chile, Campus Isla Teja s/n, Casilla 567, Valdivia, Chile. claudialetelier@uach.cl
García-Fernández
Rosa Ana
RA
Contreras-Solis
Ignacio
I
Sanchez
María Angeles
MA
Garcia-Palencia
Pilar
P
Sanchez
Belen
B
Gonzalez-Bulnes
Antonio
A
Flores
Juana María
JM
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism*; D005260:Female; D003425:Flurogestone Acetate / Q000008:administration & dosage*; D008597:Menstrual Cycle / Q000187:drug effects / Q000502:physiology*; D023421:Models, Animal; D010060:Ovulation / Q000187:drug effects / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods; D011374:Progesterone / Q000378:metabolism*; D011372:Progestins / Q000008:administration & dosage*; D011974:Receptors, LH / Q000096:biosynthesis*; D012756:Sheep
D011372:Progestins; D011974:Receptors, LH; D011374:Progesterone; D003425:Flurogestone Acetate