Association of two CETP polymorphisms with HDL levels in the Chinese obese population.
The association of two cholesterol ester transfer protein (CETP) polymorphisms, D442G and TAQIB (B1-->B2), with high-density lipoprotein (HDL) levels in 932 Chinese obese individuals (BMI >or= 27) was investigated in comparison with normal controls (BMI <or= 24). Independent association was demonstrated for TAQIB minor allele B2 and CETP442 minor allele G with elevated HDL levels. The CETP D442G polymorphism was associated with a much greater increase in HDL levels in subjects with BMI exceeding 27 kg/m(2) (+5.42 mg/dl, P = 0.0007) compared to normal controls (+1.97 mg/dl, P = 0.275), and the increase in HDL reached the highest level among subjects with BMI exceeding 30 kg/m(2) (+6.80 mg/dl, P = 0.016). TAQIB showed significant association with HDL levels only in normal BMI subgroup (P = 0.0017). TAQIB significantly interacted with serum triglyceride (TG) on modulating HDL levels (P = 0.027). The TAQIB-TG interaction effect remained marginally significant after controlling for BMI (P = 0.057). We conclude that D442G polymorphism is associated with more HDL elevation in obesity. TAQIB interacts with serum TG on modulating HDL levels, and the interaction is partly independent of BMI.
Ruan
Xiaoyang
X
Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
Ma
Lina
L
Wang
Shuyu
S
Lindpaintner
Klaus
K
Liu
Xiangjun
X
Wang
Binbin
B
Peng
Zuoqi
Z
Ma
Xu
X
Cheng
Maosheng
M
Zhang
Jinghai
J
Liu
Lisheng
L
Wang
Xingyu
X
D000483:Alleles; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics*; D006801:Humans; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D012016:Reference Values; D014280:Triglycerides / Q000097:blood / Q000235:genetics
D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D014280:Triglycerides