title: [Microbiol landscape and production of beta-lactamases with extended spectrum activity in patients with urinary tract infection].
abstract: Urinary tract infections (UTIs) are widespread in Russia. One of the major problems facing practical medicine in the country is laboratory diagnosis of pyoinflammatory diseases of the urogenital tract caused by opportunistic microorganisms. A major difficulty in this context is posed by polyresistance of certain Gram-negative bacteria (E.coli, Klebsiella spp., etc.) associated with their production of a great variety of beta-lactamases (BL). This study was designed to determine species composition of urogenital tract pathogens and evaluate their resistance to antibacterial preparations with special reference to the mechanism of resistance of BL production to this drugs. The study included 169 patients with urinary tract infections admitted to the Clinical Research Centre for Healthcare of Miners, Leninsk-Kuznetsk, between 01.02.2007 and 0.1.02.2008
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Zhevlakova
authors.forename: G V
authors.initials: GV
authors.lastname: Zakharova
authors.forename: O I
authors.initials: OI
authors.lastname: Khokhlova
authors.forename: I M
authors.initials: IM
authors.lastname: Ust'iantseva
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D006801:Humans; D012189:Retrospective Studies; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D018440:beta-Lactam Resistance / Q000502:physiology*; D001618:beta-Lactamases / Q000096:biosynthesis*; D047090:beta-Lactams / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases