Preparation and evaluation of differently sulfonated styrene-divinylbenzene cross-linked copolymer cationic exchange resins as novel carriers for drug delivery.
The differently sulfonated styrene-divinylbenzene cross-linked copolymer cationic exchange resins were prepared by oil-in-water polymerization and varied degrees of sulfonation. Several characteristics of the obtained resins were evaluated, i.e., Fourier transform infrared spectra, the ion-exchange capacity, microscopic morphology, size, and swelling. The resin characteristics were altered in relation to the degree of sulfonation, proving that differently sulfonated resins could be prepared. The behavior of chlorpheniramine (CPM) loading and in vitro release in the USP simulated gastric (SGF) and intestinal fluids (SIF) of the obtained resins were also evaluated. The CPM loaded in the resinates (drug-loaded resins) increased with the increasing degree of sulfonic group and hence the drug binding site in the employed resins. The CPM release was lower from the resins with the higher degree of sulfonic group due to the increase in the diffusive path depth. The CPM release was obviously lower in SGF than SIF because CPM, a weak base drug, ionized to a greater extent in SGF and then preferred binding with rather than releasing from the resins. In conclusion, the differently sulfonated resins could be utilized as novel carriers for drug delivery.
Akkaramongkolporn
Prasert
P
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand.
Ngawhirunpat
Tanasait
T
Opanasopit
Praneet
P
D002411:Cation Exchange Resins / Q000008:administration & dosage* / Q000737:chemistry; D002744:Chlorpheniramine / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D011137:Polystyrenes / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D014753:Vinyl Compounds / Q000008:administration & dosage* / Q000737:chemistry
D002411:Cation Exchange Resins; D004337:Drug Carriers; D011137:Polystyrenes; D014753:Vinyl Compounds; D002744:Chlorpheniramine; C024075:styrofoam; C004985:divinyl benzene