title: Semisynthesis and antiproliferative evaluation of a series of 3'-aminoflavones.
abstract: A series of 3'-aminoflavones 5,6,7,8-tetra- or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus flavonoids. These flavones were evaluated for antiproliferative activity, activation of apoptosis, and inhibition of tubulin assembly. The most antiproliferative flavones exhibit a common 5-hydroxy-6,7,8-trimethoxy substitution pattern on the A-ring.
authors.affiliation: Laboratoire de Pharmacognosie, (Univ. Paris-Sud 11, BIOCIS, UMR-8076 CNRS), Faculté de Pharmacie, av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Quintin
authors.forename: Didier
authors.initials: D
authors.lastname: Buisson
authors.forename: Sylviane
authors.initials: S
authors.lastname: Thoret
authors.forename: Thierry
authors.initials: T
authors.lastname: Cresteil
authors.forename: Guy
authors.initials: G
authors.lastname: Lewin
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D044950:Flavanones / Q000737:chemistry; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D044950:Flavanones; D047309:Flavones; C059006:tangeretin; C005274:naringin