title: Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
abstract: We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.
authors.affiliation: Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Lisette
authors.initials: L
authors.lastname: Stolk
authors.forename: Guangju
authors.initials: G
authors.lastname: Zhai
authors.forename: Joyce B J
authors.initials: JB
authors.lastname: van Meurs
authors.forename: Michael M P J
authors.initials: MM
authors.lastname: Verbiest
authors.forename: Jenny A
authors.initials: JA
authors.lastname: Visser
authors.forename: Karol
authors.initials: K
authors.lastname: Estrada
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivadeneira
authors.forename: Frances M
authors.initials: FM
authors.lastname: Williams
authors.forename: Lynn
authors.initials: L
authors.lastname: Cherkas
authors.forename: Panos
authors.initials: P
authors.lastname: Deloukas
authors.forename: Nicole
authors.initials: N
authors.lastname: Soranzo
authors.forename: Jules J
authors.initials: JJ
authors.lastname: de Keyzer
authors.forename: Victor J M
authors.initials: VJ
authors.lastname: Pop
authors.forename: Paul
authors.initials: P
authors.lastname: Lips
authors.forename: Corinne E I
authors.initials: CE
authors.lastname: Lebrun
authors.forename: Yvonne T
authors.initials: YT
authors.lastname: van der Schouw
authors.forename: Diederick E
authors.initials: DE
authors.lastname: Grobbee
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Witteman
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Huibert A P
authors.initials: HA
authors.lastname: Pols
authors.forename: Joop S E
authors.initials: JS
authors.lastname: Laven
authors.forename: Tim D
authors.initials: TD
authors.lastname: Spector
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
mesh_terms: D000367:Age Factors; D001943:Breast Neoplasms / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D008593:Menopause / Q000235:genetics*; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D016017:Odds Ratio; D010024:Osteoporosis / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D018433:Twin Studies as Topic; D044465:White People / Q000235:genetics