Redo-surgery following curative resection of pancreatic carcinoma: the difference between true and suspected recurrence.
BACKGROUND
Improving results have led to an extension of indications for re-resection of recurrent pancreatic carcinoma.


METHODS
Among 410 patients who received surgery for histologically proven pancreatic cancer, 17 underwent re-resection for a suspected local recurrence and were evaluated for overall survival, clinicopathological and perioperative data.


RESULTS
At the initial operation, resection was curative (R0/R1) in all 17 patients. Indication for re-resection was a suspected or proven recurrence of pancreatic cancer in all patients. Re-resection was possible in 5 patients. The remaining patients received a redo of the pancreaticojejunostomy or bilioenteric anastomosis (n = 2), exploration with biopsy (n = 4), and a palliative bypass (n = 6). Perioperative mortality was 6%. Median overall survival was 25 months (range 10-152 months) and 7 months following re-resection (5-29 months). In 5 of 17 patients, histology showed chronic pancreatitis (n = 4) or a benign stricture at the hepaticojejunostomy (n = 1), whereas all other patients had histologically proven recurrence. Re-resection or redo of the anastomosis was possible in 5 of 5 patients with chronic pancreatitis but only in 2 of 12 patients with true recurrence (p = 0.003).


CONCLUSIONS
Curative reoperation for recurrent pancreatic carcinoma is rarely feasible. Due to the potential for chronic pancreatitis or benign strictures as an underlying pathology, operable patients should be explored.
Seelig
Matthias H
MH
Department of General Surgery, St. Joseph Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany. m.seelig@klinikum-bochum.de
Janot
Monika
M
Chromik
Ansgar M
AM
Herzog
Torsten
T
Belyaev
Orlin
O
Weyhe
Dirk
D
Meurer
Kirsten
K
Meiser
Andreas
A
Tannapfel
Andrea
A
Uhl
Waldemar
W
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D010193:Pancreaticojejunostomy; D011446:Prospective Studies; D012086:Reoperation; D016896:Treatment Outcome