title: Surgical therapy of intrapancreatic metastasis from renal cell carcinoma.
abstract: BACKGROUND
  Pancreatic metastases from renal cell carcinoma (RCC) are clinically rare but highly resectable. The aim of this article is to identify patients who profit from pancreatic resection of RCC despite the invasiveness of the surgery.
  
  
  METHODS
  Between January 1996 and December 2007, data from 744 patients were collected in a prospective pancreatic surgery database, and patients with metastasis into the pancreas from RCC were identified.
  
  
  RESULTS
  Resective surgery was performed in 14 patients with metastasis to the pancreas from RCC. Most patients were clinically asymptomatic. The median interval between primary treatment of RCC and occurrence of pancreatic metastasis was 94 months (range 32-158). The morbidity rate was 42.8%. Patients with a metastasis size <2.5 cm had a much better survival after resection (100 months) than those with a metastasis size >2.5 cm (44 months). Moreover, the number of metastases predicts the survival after resection.
  
  
  CONCLUSIONS
  In patients with pancreatic metastases from RCC who have only limited disease, complete resection of all lesions can be successfully performed with a low rate of complications. Thus, patients with a history of RCC should be monitored for more than 10 years after nephrectomy to detect recurrence.
authors.affiliation: Department of General, Thoracic and Vascular Surgery, University of Dresden, Dresden, Germany. andreas.volk@uniklinikum-dresden.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Volk
authors.forename: Stephan
authors.initials: S
authors.lastname: Kersting
authors.forename: Ralf
authors.initials: R
authors.lastname: Konopke
authors.forename: Frank
authors.initials: F
authors.lastname: Dobrowolski
authors.forename: Stefan
authors.initials: S
authors.lastname: Franzen
authors.forename: Detlef
authors.initials: D
authors.lastname: Ockert
authors.forename: Robert
authors.initials: R
authors.lastname: Grutzmann
authors.forename: Hans Detlev
authors.initials: HD
authors.lastname: Saeger
authors.forename: Hendrik
authors.initials: H
authors.lastname: Bergert
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000556:secondary / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000601:surgery*; D016896:Treatment Outcome