Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.
Aged heterozygous Rolling Nagoya mice carrying Cav2.1alpha1 mutation show deficits with regard to spatial short-term memory using hippocampus-related object location test, but not with regard to nonspatial memory using perirhinal cortex-related object recognition test. In hippocampus, wild-type Cav2.1alpha1 mRNA exhibited lower expression and mutant-type expression was higher in aged heterozygous mice. In perirhinal cortex, there were no significantly different expressions. Alteration of age-dependent expressions of Cav2.1 channels differs in different regions with related effects on behavioral performances.
Takahashi
Eiki
E
RIKEN Brain Science Institute, Research Resources Center, Hirosawa 2-1, Wako, Saitama 351-0198, Japan. etakahashi@brain.riken.jp
Niimi
Kimie
K
Itakura
Chitoshi
C
D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D020864:Calcium Channels, N-Type / Q000235:genetics / Q000378:metabolism*; D005838:Genotype; D006624:Hippocampus / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology; D008570:Memory, Short-Term / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D009483:Neuropsychological Tests; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013028:Space Perception / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology* / Q000503:physiopathology
D020864:Calcium Channels, N-Type; D012333:RNA, Messenger