title: On the function of pentameric phospholamban: ion channel or storage form?
abstract: Phospholamban (PLN) is an integral membrane protein that inhibits the sarcoplasmic reticulum Ca(2+)-ATPase, thereby regulating muscle contractility. We report a combined electrochemical and theoretical study demonstrating that the pentameric PLN does not possess channel activity for conducting chloride or calcium ions across the lipid membrane. This suggests that the pentameric configuration of PLN primarily serves as a storage form for the regulatory function of muscle relaxation by the PLN monomer.
authors.forename: Lucia
authors.initials: L
authors.lastname: Becucci
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cembran
authors.forename: Christine B
authors.initials: CB
authors.lastname: Karim
authors.forename: David D
authors.initials: DD
authors.lastname: Thomas
authors.forename: Rolando
authors.initials: R
authors.lastname: Guidelli
authors.forename: Jiali
authors.initials: J
authors.lastname: Gao
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Veglia
mesh_terms: D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D000099211:Phospholamban
chemical_list: D002118:Calcium; D002135:Calcium-Binding Proteins; D002712:Chlorides; D007473:Ion Channels; D000099211:Phospholamban