title: Phloroglucinol compounds of therapeutic interest: global patent and technology status.
abstract: BACKGROUND
  Phloroglucinol compounds, both synthetic as well as natural, have shown a vast array of biological activities. There are a wide range of applications of phloroglucinol compounds in pharmaceuticals, cosmetics, textiles, paints and dyeing industries. Although many of the phloroglucinols have shown promising results in various biological assays, very few have reached clinics.
  
  
  OBJECTIVE
  To compile the patented information on various therapeutically active phloroglucinol molecules, so that technologies used in isolation and activity assessment of these compounds could be unearthed and the compiled information be utilized for further development of these molecules.
  
  
  METHODS
  The European Patent Office database (official website: espacenet.com) was searched with a keyword "phloroglucinol". In addition, patents were searched using names of compounds listed in our previous review.
  
  
  CONCLUSIONS
  This class holds potential for development of molecules in various therapeutic areas. There exist a number of patents on preparations that have phloroglucinol compounds as active ingredient(s). Many such preparations have been tested in vitro and/or in vivo for their efficacy and proven to be active and non-toxic. Commercialization of existing technology on phloroglucinol molecules can yield fruitful results.
authors.affiliation: National Institute of Pharmaceutical Education and Research, Department of Natural Products, Sector-67, S.A.S. Nagar, Punjab 160062, India. ipsingh@niper.ac.in
authors.forename: Inder Pal
authors.initials: IP
authors.lastname: Singh
authors.forename: Jasmeen
authors.initials: J
authors.lastname: Sidana
authors.forename: Parikshit
authors.initials: P
authors.lastname: Bansal
authors.forename: William J
authors.initials: WJ
authors.lastname: Foley
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003879:Dermatologic Agents / Q000494:pharmacology; D006801:Humans; D010276:Parasympatholytics / Q000494:pharmacology*; D010330:Patents as Topic; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D003879:Dermatologic Agents; D010276:Parasympatholytics; D010696:Phloroglucinol