title: [Disturbance of monoaminooxidase activity and indices of endogenous intoxication in patients with the first episode of schizophrenia].
abstract: An aim of the paper was to study some biochemical parameters of drug-naïve patients with the first episode of schizophrenia. Activities of platelet monoaminooxidase (MAO) and semicarbazide, a sensitive blood serum aminooxidase (BSA), levels of middle-sized molecules (MSM) and malonic dialdehyde (MDA), parameters of functional state of serum albumin were assessed in 16 patients. Severity of symptoms in patients with the first episode of schizophrenia was assessed as moderate (PANSS scores 73.1+/-12.5) before the treatment. The increase of MAO by 107%, reduction of BSA by 29% and increase of MSM level by 140% was found in patients compared to controls (p<0.01). The study of other biochemical (MDA level) and biophysical (effective albumin concentration) parameters did not yield unequivocal results. It has been suggested that MAO and BSA are integral components of pathogenetic mechanisms in patients with the first episode of schizophrenia.
authors.forename: M G
authors.initials: MG
authors.lastname: Uzbekov
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Misionzhnik
authors.forename: A B
authors.initials: AB
authors.lastname: Shmukler
authors.forename: I Ia
authors.initials: IIa
authors.lastname: Gurovich
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Gryzunov
authors.forename: N V
authors.initials: NV
authors.lastname: Smolina
authors.forename: V V
authors.initials: VV
authors.lastname: Kalinina
authors.forename: T N
authors.initials: TN
authors.lastname: Sokolova
authors.forename: T A
authors.initials: TA
authors.lastname: Moskvitina
authors.forename: V A
authors.initials: VA
authors.lastname: Shevchenko
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000201:enzymology*; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008995:Monoamine Oxidase / Q000097:blood* / Q000378:metabolism; D018579:Patient Selection; D012044:Regression Analysis; D012559:Schizophrenia / Q000097:blood / Q000175:diagnosis / Q000201:enzymology / Q000378:metabolism*; D012709:Serum Albumin / Q000032:analysis
chemical_list: D012709:Serum Albumin; D008315:Malondialdehyde; D008995:Monoamine Oxidase