title: Paclitaxel-induced interstitial pneumonia after drug-eluting stent implantation: report of a fatal case.
abstract: We report a case of paclitaxel-eluting stent implantation in an angina patient who developed interstitial pneumonia a few days afterward, and succumbed to fatal respiratory dysfunction despite corticosteroid therapy. Paclitaxel is an anti-neoplastic agent currently used as a coating substance for coronary stents to reduce the rate of restenosis. Pulmonary toxicity related to paclitaxel is not very common; however, this adverse event may on occasion be lethal. Although the efficacy and safety of drug-eluting stents for the treatment of ischemic heart disease is well established, physicians should keep in mind that paclitaxel-eluting stents have the potential to cause interstitial pneumonia.
authors.affiliation: Department of Internal Medicine, Gifu Prefectural Tajimi Hospital, Tajimi.
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuda
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Fujimaki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takano
authors.forename: Eiji
authors.initials: E
authors.lastname: Kunii
authors.forename: Ken
authors.initials: K
authors.lastname: Kato
authors.forename: Kazuko
authors.initials: K
authors.lastname: Watanabe
authors.forename: Susumu
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kiyoyasu
authors.initials: K
authors.lastname: Yamada
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yokoi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Mori
mesh_terms: D000368:Aged; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D019919:Prosthesis Implantation / Q000009:adverse effects
chemical_list: D017239:Paclitaxel