title: Enantioselective organocatalytic conjugate reduction of beta-azole-containing alpha,beta-unsaturated aldehydes.
abstract: Beta-azole-containing alpha,beta-unsaturated aldehydes were successfully reduced under highly enantioselective organocatalytic transfer hydrogenation conditions. The products were obtained in good yields and up to 94% optical purity. This simple process was successfully applied to the synthesis of the C7-C14 fragment of ulapualide A, a natural product which exhibits promising antitumor activity.
authors.affiliation: Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, F-75231 Paris Cedex 05, France.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hoffman
authors.forename: Jyotirmayee
authors.initials: J
authors.lastname: Dash
authors.forename: James H
authors.initials: JH
authors.lastname: Rigby
authors.forename: Stellios
authors.initials: S
authors.lastname: Arseniyadis
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy