title: [Study on extraction of polyphenols from the leaves of Acer truncatum and their inhibitory abilities on fatty acid synthase].
abstract: OBJECTIVE
  To optimize a technical process for extracting the polyphenols that can inhibit fatty acid synthase by ethanol from the leaves of Acer truncatum.
  
  
  METHODS
  The extracting time, extracting temperature, extracting solvent and the ratio of solvent to raw material were studied by L16 (4(5)) orthogonal experiments. The extraction rate of polyphenols and the inhibitory efficiency on the fatty acid synthase were utilized as evaluating criteria, and the optimum conditions for the extraction were obtained through summing up the above factors.
  
  
  RESULTS
  The efficient technological conditions were as follows: the concentration of ethanol was 60% (v/v), the ratio of solvent to raw material was 1 g: 30 mL; and the stirring time was 1.5 h at 50 degrees C.
  
  
  CONCLUSIONS
  The polyphenols that extracted from the leaves of Acer truncatum have inhibitory activity against fatty acid synthase and some of them have stronger inhibitory effect.
authors.affiliation: College of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
authors.forename: Yan-bin
authors.initials: YB
authors.lastname: Ye
authors.forename: Shuai
authors.initials: S
authors.lastname: Yang
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Jian-qiang
authors.initials: JQ
authors.lastname: Guo
authors.forename: Ying-xia
authors.initials: YX
authors.lastname: Zhang
mesh_terms: D031002:Acer / Q000737:chemistry*; D000704:Analysis of Variance; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors; D010636:Phenols / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013997:Time Factors
chemical_list: D010636:Phenols; D064429:Fatty Acid Synthases