Clinical implications of cortical microvasculature in adult Moyamoya disease.
We analyzed cortical microvascular parameters using intraoperative ICG (Indocyaninegreen)-Videoangiography in 13 patients with Moyamoya disease, and carried out correlative studies by comparing them with clinical parameters obtained by digital subtraction angiography, physical examination, and regional cerebral blood flow studies. Patients with reduced cerebrovascular reserve capacity were characterized by increased microvascular surface area (MVSA). In addition, MVSA correlated positively with arterial microvascular transit time. Asymptomatic patients were characterized by increased arterial microvascular transit time. We show that patients with a higher arteriogenic potential to alter cortical microvasculature are characterized by a more favorable hemodynamic situation and reduced clinical symptoms.
Czabanka
Marcus
M
Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, Berlin 13353, Germany. marcus.czabanka@charite.de
Peña-Tapia
Pablo
P
Schubert
Gerrit Alexander
GA
Woitzik
Johannes
J
Horn
Peter
P
Schmiedek
Peter
P
Vajkoczy
Peter
P
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D002533:Cerebral Angiography / Q000379:methods; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004396:Coloring Agents; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D055806:Microvessels / Q000503:physiopathology*; D008875:Middle Aged; D009072:Moyamoya Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D014741:Video Recording; D055815:Young Adult
D004396:Coloring Agents; D007208:Indocyanine Green