title: Time-resolved spectrally constrained method for the quantification of chromophore concentrations and scattering parameters in diffusing media.
abstract: We have devised and experimentally validated, on tissue-simulating phantoms and in vivo, a time-resolved spectral fitting analysis for direct assessment of chromophore concentrations and scattering parameters. Experimental data have been acquired with a time-resolved broadband system based on supercontinuum light generated in a photonic crystal fiber and a 32 channel Time Correlated Single Photon Counting system. The novel method is more robust than conventional techniques, especially at low signal-to-noise ratio.
authors.forename: C
authors.initials: C
authors.lastname: D'Andrea
authors.forename: L
authors.initials: L
authors.lastname: Spinelli
authors.forename: A
authors.initials: A
authors.lastname: Bassi
authors.forename: A
authors.initials: A
authors.lastname: Giusto
authors.forename: D
authors.initials: D
authors.lastname: Contini
authors.forename: J
authors.initials: J
authors.lastname: Swartling
authors.forename: A
authors.initials: A
authors.lastname: Torricelli
authors.forename: R
authors.initials: R
authors.lastname: Cubeddu