[Clinical aspect of recent progress in phosphate metabolism. The pathophysiology of diseases caused by aberrant actions of FGF23].
FGF23 is a humoral factor that is produced by osteocytes and reduces serum phosphate and 1,25-dihydroxyvitamin D levels by binding to a complex comprised of Klotho and some FGF receptor in kidney. After the identification of FGF23, it has been shown that aberrant actions of FGF23 underlie several diseases. While several kinds of hypophosphatemic rickets/osteomalacia are caused by excess actions of FGF23, deficient actions of FGF23 result in hyperphosphatemic tumoral calcinosis.
Shimizu
Yuichiro
Y
Division of Nephrology and Endocrinology, Department of Medicine, University of Tokyo Hospital.
Fukumoto
Seiji
S
D000818:Animals; D002114:Calcinosis / Q000209:etiology*; D002117:Calcitriol / Q000378:metabolism; D053098:Familial Hypophosphatemic Rickets / Q000209:etiology*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000737:chemistry / Q000502:physiology*; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D054559:Hyperphosphatemia / Q000209:etiology*; D000090265:Klotho Proteins; D010018:Osteomalacia / Q000209:etiology*; D010710:Phosphates / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism
C000717427:FGF23 protein, human; D010710:Phosphates; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; D002117:Calcitriol