title: Cancer diagnosis in first-degree relatives and non-small cell lung cancer risk: results from a multi-centre case-control study in Europe.
abstract: Because aggregation of cancers at different sites can occur in families, cancer could be considered as a broad phenotype with shared genetic factors. Here, we report results from a multi-centre case-control study of non-small cell lung cancer (NSCLC), with particular emphasis on a history of cancer in first-degree relatives and the risk of lung cancer. From 2002 to 2006, 733 NSCLC patients treated surgically were recruited in 8 European countries and matched to 1312 controls, by centre, sex and age. We used multivariate conditional logistic regression models to test the association between a history of cancer in first-degree relatives and risk of NSCLC. A family history of lung cancer was associated with an odds ratio (OR) for early-onset (54 years or younger) NSCLC of 4.72 (95% confidence interval [CI]=1.02-21.90). A family history of gastric cancer was associated with an OR for NSCLC of 1.82 (95% CI=1.08-3.06) and for late-onset (55 years or older) NSCLC of 2.92 (95% CI=1.10-7.75). Our findings provide further evidence of a familial predisposition to lung cancer and support the hypothesis that family history is a significant risk factor for the disease. Because of the inherent potential for bias in familial case-control study design, cautious interpretation is warranted.
authors.affiliation: Roy Castle Lung Cancer Research Programme, Cancer Research Centre, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Adrian
authors.initials: A
authors.lastname: Cassidy
authors.forename: Jessica
authors.initials: J
authors.lastname: Balsan
authors.forename: Aurélien
authors.initials: A
authors.lastname: Vesin
authors.forename: Xifeng
authors.initials: X
authors.lastname: Wu
authors.forename: Triantafillos
authors.initials: T
authors.lastname: Liloglou
authors.forename: Christian
authors.initials: C
authors.lastname: Brambilla
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Timsit
authors.forename: John K
authors.initials: JK
authors.lastname: Field
mesh_terms: D017668:Age of Onset; D000368:Aged; D001194:Asbestos / Q000009:adverse effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D004812:Epidemiologic Methods; D005060:Europe / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics
chemical_list: D001194:Asbestos