The microanatomy of B cell activation.
The logistic problem of B cell antigen encounter in the lymph node has recently been studied by dynamic imaging using two-photon microscopy. These studies combined with the early studies of antigen transport have yielded a more complete picture of the orchestration of B cell activation in vivo. Here we summarize the recent advances and focus on the specialized macrophages that are critical to this process and the role of B cells themselves as antigen transporting cells.
Phan
Tri Giang
TG
Garvan Institute of Medical Research, NSW, Australia. t.phan@garvan.org.au
Gray
Elizabeth E
EE
Cyster
Jason G
JG
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D000941:Antigens / Q000276:immunology / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology*; D001692:Biological Transport / Q000276:immunology; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D018448:Models, Immunological
D000941:Antigens