title: Bisbenzylisoquinoline alkaloids from Cocculus pendulus.
abstract: A new bisbenzylisoquinoline alkaloid, 1,2-dihydrokurramine (1), and four known bisbenzylisoquinoline alkaloids 2-5, along with a morphinan alkaloid 6 were isolated from Cocculus pendulus. The structures for these compounds were deduced by spectroscopic methods. All bisbenzylisoquinoline alkaloids showed inhibitory activities against acetyl- and butyrylcholinesterases.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
authors.lastname: Atta-ur-Rahman
authors.lastname: Atia-tul-Wahab
authors.forename: S
authors.initials: S
authors.lastname: Zia Sultani
authors.forename: Sarfraz A
authors.initials: SA
authors.lastname: Nawaz
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D044182:Benzylisoquinolines / Q000737:chemistry* / Q000494:pharmacology; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D031605:Cocculus / Q000737:chemistry*; D004789:Enzyme Activation / Q000187:drug effects; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D044182:Benzylisoquinolines; D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase