Keys to open chromatin for transcription activation: FACT and Asf1.
In this issue of Molecular Cell, Takahata et al. (2009) dissect the mechanisms preceding transcription initiation, revealing a wave of nucleosome eviction, which spreads from distant cis-regulatory elements to promoters and which requires the activity of histone chaperones, FACT and Asf1.
Krebs
Arnaud
A
Functional Genomics Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, ILLKIRCH, France.
Tora
László
L
D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006609:High Mobility Group Proteins / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D008957:Models, Genetic; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D009707:Nucleosomes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation; D035602:Transcriptional Elongation Factors / Q000235:genetics / Q000378:metabolism*
C109731:ASF1 protein, S cerevisiae; D018797:Cell Cycle Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D006657:Histones; D018832:Molecular Chaperones; D009707:Nucleosomes; C073537:SSRP1 protein, human; D029701:Saccharomyces cerevisiae Proteins; D035602:Transcriptional Elongation Factors