title: Transgenic and infectious animal models of HIV-associated nephropathy.
abstract: HIV-associated nephropathy (HIVAN) is a major cause of HIV-related morbidity and mortality. Transgenic and infectious models of HIVAN faithfully recapitulate the human disease and are important tools in advancing our understanding of disease pathogenesis, genetic susceptibility, and therapeutic intervention beyond the inhibition of viral replication. This review discusses the available transgenic murine models and infectious models of HIVAN in mice, rats, nonhuman primates, and felines. Particular emphasis is given to cell type-specific HIV expression as well as partial HIV genome expression used to map HIV-1 Nef and Vpr as pathologic determinants.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Rosenstiel
authors.forename: Ali
authors.initials: A
authors.lastname: Gharavi
authors.forename: Vivette
authors.initials: V
authors.lastname: D'Agati
authors.forename: Paul
authors.initials: P
authors.lastname: Klotman
mesh_terms: D016263:AIDS-Associated Nephropathy / Q000821:virology; D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D006678:HIV / Q000235:genetics; D016089:Immunodeficiency Virus, Feline; D051379:Mice; D008822:Mice, Transgenic; D015302:Simian Immunodeficiency Virus