Oxidative aromatization of 1,4-dihydropyridines and pyrazolines using HbA-H(2)O(2): An efficient biomimetic catalyst system providing metabolites of drug candidates.
Human hemoglobin (HbA) efficiently catalyses the oxidative aromatization of 1,4-dihydropyridines (1,4-DHPs) and pyrazolines with hydrogen peroxide in phosphate buffer. The results of the study reveal that the rates of oxidative aromatization of 1,4-DHPs are substituent dependent. Thus, the present study is very useful in understanding the metabolism of 1,4-DHP drugs in liver by cytochrome P450 and designing novel drugs as well as modifying the existing drugs for better pharmacokinetic profile.
Kumar
Atul
A
Medicinal and Process Chemistry Division, Central Drug Research Institute(dagger), Lucknow 226001, India. dratulsax@gmail.com
Maurya
Ram Awatar
RA
Sharma
Siddharth
S
D000818:Animals; D032701:Biomimetics; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D006418:Heme; D006441:Hemoglobin A / Q000737:chemistry*; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry*
D004095:Dihydropyridines; D010710:Phosphates; D011720:Pyrazoles; D006418:Heme; C038806:1,4-dihydropyridine; D006441:Hemoglobin A; D003577:Cytochrome P-450 Enzyme System; D006861:Hydrogen Peroxide; D010100:Oxygen