Predictive value of selected biochemical markers of brain damage for functional outcome in ischaemic stroke patients.
OBJECTIVE
Previous studies suggested that biochemical markers of brain damage could act as prognostic factors in ischaemic stroke. The aim of the present study was to assess predictive value of the selected biomarkers S100B protein, neuron-specific enolase (NSE), C-reactive protein (CRP) and D-dimers, as well as GABA and excitatory amino-acids (EAA) measured in blood for 3-month functional outcome in ischaemic stroke patients.


METHODS
We investigated 54 patients with ischaemic stroke (mean age: 73.3 +/-11.7). Serum concentrations of S100B, NSE, CRP, EAA and GABA, as well as plasma concentrations of D-dimers, were assessed in blood samples taken at admission and at 12, 24, and 72 hours after stroke onset. Functional status was measured with modified Rankin Scale (mRS) 3 months after stroke onset.


RESULTS
Significant independent predictors of outcome in ischaemic stroke patients 3 months after stroke were: S100B level at 12 h (OR: 1.7; 95% CI: 0.5-7.0; p = 0.007), NSE at 12 h (OR: 2.4; 95% CI: 0.7-8.1; p = 0.037), 24 h (OR: 10.2; 95% CI: 2.4-43.2; p = 0.0007), and 72 h (OR: 10.2; 95% CI: 2.3-45.0; p = 0.0001), CRP at 72 h (OR: 8.3; 95% CI: 1.5-45.4; p = 0.009) and D-dimers at admission (OR: 4.8; 95% CI: 1.1-20.7; p = 0.02), 24 h (OR: 5.5; 95% CI: 1.4-20.9; p = 0.004), and 72 h after stroke onset (OR: 2.7; 95% CI: 0.6-11.8; p = 0.01).


CONCLUSIONS
The results of the present study are consistent with previous evidence indicating that selected biomarkers could help in prediction of the outcome in ischaemic stroke early after symptoms onset.
Sienkiewicz-Jarosz
Halina
H
I Klinika Neurologiczna, Instytut Psychiatrii i Neurologii, ul. J. Sobieskiego 9, 02-957 Warszawa. jarosz@ipin.edu.pl
Gałecka-Wolska
Maria
M
Bidziński
Andrzej
A
Turzyńska
Danuta
D
Sobolewska
Alicja
A
Lipska
Beata
B
Płaźnik
Adam
A
Ryglewicz
Danuta
D
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood / Q000150:complications*; D002097:C-Reactive Protein / Q000378:metabolism; D018846:Excitatory Amino Acids / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D020521:Stroke / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D005680:gamma-Aminobutyric Acid / Q000097:blood
D015415:Biomarkers; D018846:Excitatory Amino Acids; D005338:Fibrin Fibrinogen Degradation Products; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; C036309:fibrin fragment D; D005680:gamma-Aminobutyric Acid; D002097:C-Reactive Protein; D010751:Phosphopyruvate Hydratase