Antioxidant activity and antitumor activity (in vitro) of xyloglucan selenious ester and sulfated [corrected] xyloglucan.
Two kinds of xyloglucan derivatives (xyloglucan selenious ester and sulfated xyloglucan) were prepared and evaluated on antioxidant activity and antitumor activity. Compared with xyloglucan, xyloglucan derivatives have new bioactivity against oxidative damage and tumor. Furthermore, xyloglucan selenious ester is more potent than sulfated xyloglucan at antioxidant activity and antitumor activity in vitro. The current data suggest for the first time that selenition of xyloglucan significantly increases its bioactivity and the chemical modification of polysaccharide may allow the preparation of derivatives with new properties and a variety of applications.
Cao
Yu
Y
Department of Applied Chemistry & Biotechnology, Graduate School of Engineering, University of Fukui, 3-9-1 Bunkyo, Fukui 910-8507, Japan. caoyu@iccas.ac.cn
Ikeda
Isao
I
D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004952:Esters / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005936:Glucans / Q000494:pharmacology*; D006801:Humans; D012643:Selenium / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013431:Sulfates / Q000378:metabolism*; D014990:Xylans / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000975:Antioxidants; D004952:Esters; D016166:Free Radical Scavengers; D005936:Glucans; D013431:Sulfates; D014990:Xylans; C029353:xyloglucan; D012643:Selenium