title: Neuroprotective effects of estrogen therapy for cognitive and neurobiological profiles of monkey models of menopause.
abstract: Many postmenopausal women question whether to start or continue hormone therapy because of recent clinical trial negative results. However, evidence from other studies of postmenopausal women, and from studies in menopausal monkeys, indicate that estrogen has neurocognitive protective effects, particularly when therapy is initiated close to the time of menopause before neural systems become increasingly compromised with age. In this review, we present studies of menopausal women and female monkeys that support the concept that estrogen therapies protect both cognitive function and neurobiological processes.
authors.affiliation: Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. mlvoytko@wfubmc.edu
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Voytko
authors.forename: Gregory Paul
authors.initials: GP
authors.lastname: Tinkler
authors.forename: Carole
authors.initials: C
authors.lastname: Browne
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Tobin
mesh_terms: D000367:Age Factors; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D003071:Cognition / Q000187:drug effects*; D015914:Estrogen Replacement Therapy / Q000706:statistics & numerical data*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008593:Menopause / Q000378:metabolism*; D023421:Models, Animal; D018696:Neuroprotective Agents / Q000494:pharmacology*; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D013569:Synapses / Q000187:drug effects*
chemical_list: D004967:Estrogens; D018696:Neuroprotective Agents; D017981:Receptors, Neurotransmitter