The scent of Mycobacterium tuberculosis--part II breath.
Recent figures show that tuberculosis (TB) is advancing and killing more than two million people annually, yet no breakthrough in rapid diagnostics is in sight. Volatile metabolites of Mycobacterium tuberculosis (MTB) may provide just that. It is well established that MTB produces nicotinic acid in vitro. We have converted the free acid into methyl nicotinate and detected statistically significant differences in the breath of smear positive patients compared with healthy (smear negative) subjects.
Syhre
Mona
M
Otago University, Christchurch School of Medicine and Health Sciences, New Zealand. mona.syhre@otago.ac.nz
Manning
Laurens
L
Phuanukoonnon
Suparat
S
Harino
Paul
P
Chambers
Stephen T
ST
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests / Q000379:methods*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D009539:Nicotinic Acids / Q000032:analysis*; D009812:Odorants / Q000032:analysis; D010865:Pilot Projects; D013183:Sputum / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis*; D055815:Young Adult
D015415:Biomarkers; D009539:Nicotinic Acids; C008473:methyl nicotinate