title: Sonographic septation: a predictor of sequelae of tuberculous pleurisy after treatment.
abstract: BACKGROUND
  Findings in the literature have been quite conflicting with respect to predicting residual pleural thickening (RPT) in tuberculous pleurisy (TP). The aim of this study was to determine which sonographic feature of TP might help in predicting the development of RPT.
  
  
  METHODS
  Eighty-seven patients with TP were enrolled prospectively. The initial sonographic features were classified as anechoic, homogenously echogenic, complex non-septated and complex septated. The RPT level was measured 12 months after the start of antituberculosis (TB) treatment. Spirometry was performed 6 and 12 months after the start of anti-TB treatment.
  
  
  RESULTS
  A higher odds of an RPT level >10 mm was found in patients with positive TB bacillus culture in pleural fluid (OR, 20.9; 95% CI, 2.2 to 198.0) and a complex septated sonographic pattern (OR, 145.0; 95% CI, 22.3 to 942.3). A complex septated sonographic pattern can predict RPT with a sensitivity of 80%, specificity of 96%, positive predictive value of 84% and negative predictive value of 94%. Patients with an RPT level >10 mm had a lower forced vital capacity than those without (75.4% (9.2%) predicted vs 83.2% (9.5%) predicted, p<0.01)
  
  
  CONCLUSIONS
  A complex septated sonographic pattern is a useful sign to predict an RPT level >10 mm 1 year after the start of anti-TB treatment. An RPT level >10 mm is associated with a high probability of decreased lung volumes. Therefore, the initial sonographic feature is beneficial in predicting the sequelae of TP after treatment.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, E-Da Hospital, Jiau-Shu Tsuen, Yan-Chau Shiang, Kaohsiung, Taiwan.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Lai
authors.forename: M-C
authors.initials: MC
authors.lastname: Su
authors.forename: H-H
authors.initials: HH
authors.lastname: Weng
authors.forename: J-T
authors.initials: JT
authors.lastname: Wu
authors.forename: C-T
authors.initials: CT
authors.lastname: Chiu
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010994:Pleura / Q000000981:diagnostic imaging* / Q000473:pathology; D010996:Pleural Effusion / Q000000981:diagnostic imaging* / Q000209:etiology; D013147:Spirometry; D014396:Tuberculosis, Pleural / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D014463:Ultrasonography
chemical_list: D000995:Antitubercular Agents