title: The role of GSK3 in Alzheimer disease.
abstract: Mutations in app, ps-1 and ps-2 genes result in the appearance of Familial Alzheimer disease (FAD). Although, in many cases, those mutations result in an increase of the amount of beta amyloid peptide, there is not a clear correlation between that amount and the time of the onset of the disease. Thus, other factors may explain how mutations in those genes result in the appearance of neurodegeneration. In this minireview we propose that GSK3 could be one of those factors.
authors.affiliation: Centro de Bioligía Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Campus Cantoblanco, 28049 Madrid, Spain. fhernadez@cbm.uam.es
authors.forename: Félix
authors.initials: F
authors.lastname: Hernández
authors.forename: Elena Gómez
authors.initials: EG
authors.lastname: de Barreda
authors.forename: Almudena
authors.initials: A
authors.lastname: Fuster-Matanzo
authors.forename: Paloma
authors.initials: P
authors.lastname: Goñi-Oliver
authors.forename: José J
authors.initials: JJ
authors.lastname: Lucas
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*; D006801:Humans; D051379:Mice; D010766:Phosphorylation; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016875:tau Proteins; D038362:Glycogen Synthase Kinase 3