title: Biliary strictures and hepatic artery flow abnormalities in split liver transplants.
abstract: The aim of this study was to examine the role of HA flow abnormalities in the development of biliary strictures following split liver transplants. Data was obtained from a prospective data base of all patients undergoing split liver transplants from 2000-2008 with a follow up time of at least six months. Forty-six transplants were performed in 44 patients. Fourteen of 46 developed strictures of whom four were intrahepatic and 10 anastomotic. Nine of 14 with strictures had either hepatic artery thromobosis (HAT, four) or abnormalities of HA flow identified by routine Doppler ultrasound (5) compared with two of 32 without strictures (p < 0.02, (one temporary loss of flow and one HA aneurysm). There were no differences between the stricture and non stricture group with regard to age or weight at transplant, donor age, cold and warm ischemia times or intraoperative portal vein flow though there was a significant decrease in intraoperative HA flow in the stricture group. In conclusion, both HAT and hepatic artery flow abnormalities are associated with biliary strictures in the majority of split liver transplants. However, unrecognised abnormalities in HA flow and or other factors are likely to contribute.
authors.affiliation: Department of Gastroenterology, The Children's Hospital at Westmead, Westmead, NSW, Australia. tedo@chw.edu.au
authors.forename: Edward V
authors.initials: EV
authors.lastname: O'Loughlin
authors.forename: Michael O
authors.initials: MO
authors.lastname: Stormon
authors.forename: Albert
authors.initials: A
authors.lastname: Shun
authors.forename: Deborah
authors.initials: D
authors.lastname: Verran
authors.forename: Vicki
authors.initials: V
authors.lastname: Jermyn
authors.forename: Christopher
authors.initials: C
authors.lastname: Wong
authors.forename: David
authors.initials: D
authors.lastname: Lord
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical; D017734:Bile Ducts, Extrahepatic / Q000601:surgery*; D001783:Blood Flow Velocity; D002675:Child, Preschool; D002758:Cholangiography; D002779:Cholestasis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D001651:Cholestasis, Extrahepatic / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D005500:Follow-Up Studies; D006499:Hepatic Artery / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007582:Jejunostomy / Q000379:methods*; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D011446:Prospective Studies; D014463:Ultrasonography; D014656:Vascular Surgical Procedures / Q000379:methods*