Reduction in QSART and vasoactive intestinal polypeptide expression in the skin of Parkinson's disease patients and its relation to dyshidrosis.
BACKGROUND
With regards to dyshidrosis in Parkinson's disease (PD), there is no established and consistent view on the occurrence sites, frequency and etiology, although there have been several reports on hypohidrosis of the limbs and sudoresis on the face/cervical region.


METHODS
Hydrosis in the forearms of PD patients and healthy individuals were compared by quantitative sudomotor axon reflex test (QSART). The expression of various neuropeptides and alpha-synuclein was examined with immunohistochemical staining.


RESULTS
There was a significant reduction in QSART of PD patients but not of healthy controls. Reduced expression of vasoactive intestinal polypeptide (VIP) was also detected in the sweat glands of PD patients.


CONCLUSIONS
Reduction in QSART and VIP expression in the sweat glands might be involved in the dyshidrosis of PD patients.
Kawada
Morihiro
M
Department of Dermatology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.
Tamada
Yasuhiko
Y
Simizu
Hirokazu
H
Yanagishita
Takeshi
T
Yamashita
Noriko
N
Ishida
Natsuko
N
Watanabe
Daisuke
D
Yoshida
Mari
M
Ibi
Tatsu
T
Sahashi
Kou
K
Hashizume
Yoshio
Y
Matsumoto
Yoshinari
Y
D000368:Aged; D001369:Axons / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010300:Parkinson Disease / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D012018:Reflex / Q000502:physiology*; D012867:Skin / Q000378:metabolism / Q000503:physiopathology*; D013543:Sweat Gland Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D013545:Sweat Glands / Q000294:innervation / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000096:biosynthesis*; D051844:alpha-Synuclein / Q000096:biosynthesis
D051844:alpha-Synuclein; D014660:Vasoactive Intestinal Peptide