title: Loss of heterozygosity at the 9p21-24 region and identification of BRM as a candidate tumor suppressor gene in head and neck squamous cell carcinoma.
abstract: We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to be a target for deletion of the 9p21 region. However, novel frequent chromosomal deletion and a candidate tumor suppressor gene, BRM at the 9p24 region, were detected. Moreover, comparison of clinicopathological variables demonstrated that loss of heterozygosity at the BRM locus was associated with a worse prognosis.
authors.affiliation: Department of Oral Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Wakayama Medical University, Wakayama, Japan. mgunduz@md.okayama-u.ac.jp
authors.forename: Esra
authors.initials: E
authors.lastname: Gunduz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gunduz
authors.forename: Mahmoud Al Sheik
authors.initials: MA
authors.lastname: Ali
authors.forename: Levent
authors.initials: L
authors.lastname: Beder
authors.forename: Ryo
authors.initials: R
authors.lastname: Tamamura
authors.forename: Naoki
authors.initials: N
authors.lastname: Katase
authors.forename: Susumu
authors.initials: S
authors.lastname: Tominaga
authors.forename: Noboru
authors.initials: N
authors.lastname: Yamanaka
authors.forename: Kenji
authors.initials: K
authors.lastname: Shimizu
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nagatsuka
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002899:Chromosomes, Human, Pair 9; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D005838:Genotype; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D010641:Phenotype; D014157:Transcription Factors / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: C084011:SMARCA2 protein, human; D014157:Transcription Factors