title: Successful salvage therapy with daptomycin after linezolid and vancomycin failure in a liver transplant recipient with methicillin-resistant Staphylococcus aureus endocarditis.
abstract: Infective endocarditis is a rare complication affecting solid organ transplant recipients. Staphylococcus aureus is a common cause of infective endocarditis accounting for about 30% of cases. We present a case of nosocomial methicillin-resistant S. aureus endocarditis with persistent bacteremia, in a patient following orthotopic liver transplantation. We were unable to eradicate this infection with primary linezolid therapy or with secondary treatment with combined vancomycin and rifampicin, but successfully treated it with daptomycin, in addition to tricuspid and aortic valve replacement.
authors.affiliation: Department of General, Visceral, and Transplant Surgery, University Hospital Essen, Essen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Vernadakis
authors.forename: F H
authors.initials: FH
authors.lastname: Saner
authors.forename: P-M
authors.initials: PM
authors.lastname: Rath
authors.forename: G M
authors.initials: GM
authors.lastname: Kaiser
authors.forename: Z
authors.initials: Z
authors.lastname: Mathe
authors.forename: J
authors.initials: J
authors.lastname: Treckmann
authors.forename: A
authors.initials: A
authors.lastname: Paul
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D017576:Daptomycin / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D000069349:Linezolid; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008875:Middle Aged; D023303:Oxazolidinones / Q000627:therapeutic use; D016879:Salvage Therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D017211:Treatment Failure; D016896:Treatment Outcome; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid; D017576:Daptomycin