Is preeclampsia an autoimmune disease?
Preeclampsia is a life-threatening hypertensive disease of pregnancy. The condition is characterized by the presence of autoantibodies that activate the major angiotensin receptor, AT(1). Research conducted during the past decade has shown that these autoantibodies activate AT(1) receptors on a variety of cell types and provoke biological responses that are relevant to the pathophysiology of preeclampsia. The introduction of these autoantibodies into pregnant mice results in hypertension, proteinuria and a variety of other features of preeclampsia including small fetuses and placentas. These findings demonstrate the pathophysiological role of these autoantibodies in preeclampsia. The biological properties of these autoantibodies can be blocked by a 7-amino acid peptide that corresponds to a specific sequence associated with the second extracellular loop of the AT(1) receptor. The fact that autoantibodies from different individuals are directed to a common epitope provides obvious diagnostic and therapeutic opportunities. Research reviewed here raises the intriguing possibility that preeclampsia may be a pregnancy-induced autoimmune condition characterized by the presence of disease-causing angiotensin receptor activating autoantibodies.
Xia
Yang
Y
Department of Biochemistry and Molecular Biology, The University of Texas -- Houston, Medical School, Houston, TX 77030, USA. yang.xia@uth.tmc.edu
Kellems
Rodney E
RE
D019264:Adoptive Transfer; D043925:Angiogenesis Inducing Agents / Q000276:immunology / Q000378:metabolism; D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000276:immunology* / Q000378:metabolism; D011247:Pregnancy; D017382:Reactive Oxygen Species / Q000276:immunology / Q000378:metabolism; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology / Q000378:metabolism*; D019851:Thrombophilia / Q000276:immunology / Q000378:metabolism; D013925:Thromboplastin / Q000276:immunology / Q000378:metabolism
D043925:Angiogenesis Inducing Agents; D001323:Autoantibodies; D017382:Reactive Oxygen Species; D044140:Receptor, Angiotensin, Type 1; D013925:Thromboplastin