Protein kinase A regulatory subunit interacts with P-Type ATPases in Trypanosoma cruzi.
Cyclic AMP-protein kinase A (PKA) signaling is important for the growth and differentiation of Trypanosoma cruzi. Immunofluorescence suggests that PKA can associate with the plasma membrane of trypomastigotes. We found that the PKA regulatory subunit interacts with several P-type ATPases. These P-type ATPases may play a role in anchoring PKA to the plasma membrane in T. cruzi.
Bao
Yi
Y
Department of Pathology and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Weiss
Louis M
LM
Hashimoto
Muneaki
M
Nara
Takeshi
T
Huang
Huan
H
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D011485:Protein Binding; D021122:Protein Subunits; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D015800:Protozoan Proteins / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000201:enzymology*
D021122:Protein Subunits; D015800:Protozoan Proteins; D017868:Cyclic AMP-Dependent Protein Kinases; D006180:Proton-Translocating ATPases