title: Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.
abstract: Hop acids, a family of bitter compounds derived from the hop plant (Humulus lupulus), have been reported to exert a wide range of effects, both in vitro and in vivo. They exhibit potential anticancer activity by inhibiting cell proliferation and angiogenesis, by inducing apoptosis, and by increasing the expression of cytochrome P450 detoxification enzymes. Furthermore, hop bitter acids are effective against inflammatory and metabolic disorders, which makes them challenging candidates for the treatment of diabetes mellitus, cardiovascular diseases, and metabolic syndrome. This review summarizes the current knowledge on hop bitter acids, including both phytochemical aspects, as well as the biological and pharmacological properties of these compounds.
authors.affiliation: Laboratory of Pharmacognosy and Phytochemistry, Ghent University-UGent, Gent, Belgium.
authors.forename: Marjan
authors.initials: M
authors.lastname: Van Cleemput
authors.forename: Ko
authors.initials: K
authors.lastname: Cattoor
authors.forename: Karolien
authors.initials: K
authors.lastname: De Bosscher
authors.forename: Guy
authors.initials: G
authors.lastname: Haegeman
authors.forename: Denis
authors.initials: D
authors.lastname: De Keukeleire
authors.forename: Arne
authors.initials: A
authors.lastname: Heyerick
mesh_terms: D000143:Acids / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004195:Disease Models, Animal; D006801:Humans; D027582:Humulus / Q000737:chemistry*; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D000143:Acids; D000972:Antineoplastic Agents, Phytogenic