Preparation, in vitro and in vivo evaluation of solid-state self-nanoemulsifying drug delivery system (SNEDDS) of vitamin A acetate.
Vitamin A self-nanoemulsifying drug delivery system (SNEDDS), which comprises soybean oil, Cremophor EL, and Capmul MCM-C8, was prepared and mixed with different grades of Avicel to produce homogenized powders. The resultant powders were compressed into tablets. The prepared tablets were characterized for their thickness, hardness, friability, disintegration time, and dissolution rate. In addition, the relative bioavailability of the tablets in comparison to solid-state Vitamin A oily solution (SSVAOS) tablets was investigated in rats. Vitamin A dissolution rate was markedly different from one formulation to another. From the bioavailability data, it was observed that Vitamin A SNEDD tablets have higher bioavailability (relative bioavailability 143.68%) compared with SSVAOS tablets. The AUC and C(max) of Vitamin A SNEDD tablets were found to be significantly different from that of SSVAOS tablets.
Taha
Ehab I
EI
Department of Pharmaceutics, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. eelbadawi@ksu.edu.sa
Al-Suwayeh
Saleh A
SA
Anwer
Md Khalid
MK
D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002482:Cellulose / Q000737:chemistry; D004224:Diterpenes; D016503:Drug Delivery Systems; D004655:Emulsions; D005079:Excipients / Q000737:chemistry*; D006244:Hardness; D008297:Male; D053758:Nanoparticles; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000084562:Retinyl Esters; D012995:Solubility; D013607:Tablets; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D004224:Diterpenes; D004655:Emulsions; D005079:Excipients; D014677:Pharmaceutical Vehicles; D000084562:Retinyl Esters; D013607:Tablets; D014801:Vitamin A; C009166:retinol acetate; D002482:Cellulose; C109691:microcrystalline cellulose