Nukacin ISK-1, a bacteriostatic lantibiotic.
We determined the mode of action of nukacin ISK-1. It did not cause membrane potential dissipation or the efflux of ATP or K(+) ions from the cells of a sensitive bacterial strain; however, it blocked the membrane depolarization activity of nisin. Nukacin ISK-1-treated cells had single arrangements of cells without the formation of a complete septum. A remarkable reduction in cell wall width was also observed, but cytoplasmic content was unaffected. We concluded that nukacin ISK-1 is bacteriostatic.
Asaduzzaman
Sikder M
SM
Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812-8581, Japan.
Nagao
Jun-ichi
J
Iida
Hiroshi
H
Zendo
Takeshi
T
Nakayama
Jiro
J
Sonomoto
Kenji
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D001430:Bacteriocins / Q000737:chemistry / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D046529:Microscopy, Electron, Transmission; D008954:Models, Biological; D009561:Nisin / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; C421186:nukacin ISK-1; D009561:Nisin; C102526:nisin A