title: [Cardiac surgery in patients with heparin-induced thrombocytopenia (HIT II)].
abstract: Heparin-induced thrombocytopenia (HIT) might be life-threatening in patients undergoing open heart surgery, due to thromboembolic events, thrombocytopenia and bleeding. If cardiac surgery with cardiopulmonary bypass (CPB) is necessary, anticoagulation therapy will be based on usage of danaparoid or direct thrombin inhibitors. Female patient was switched from per oral anticoagulant therapy to low molecular heparin therapy preparing for reredo mitral valve replacement due to endocarditis and artificial valve thrombosis. In next 10 days, thrombocytopenia was obvious (Tr 302,000 mm3 to 11,000 mm3) , and diagnoses of HIT were done. Anticoagulant therapy was continued with danaparoid, 750 IU/12 h sc. During the surgery, reredo mitral valve replacement and aortocoronary bypass on anterior descending coronary artery, blood salvage technique with rhirudin (intravenous bolus 0.4 mg/kg, in CPB prajming solution 0.4 mg/kg and continuous infusion during CPB 0.15 mg/kg/h) during cardiopulmonary bypass was used. Active coagulation time and +++ were monitored, without any sign of micro thrombosis in circuit. Postoperatively, per oral anticoagulation therapy was initiated with prolonged postoperative treatment due to basic disease, endocarditis. Patient was discharged from hospital on 21st postoperative day without any complication.
authors.affiliation: Klinika za anesteziju i intenzivno lecenje Beograd.
authors.forename: M D
authors.initials: MD
authors.lastname: Jović
authors.forename: D G
authors.initials: DG
authors.lastname: Nezić
authors.forename: B M
authors.initials: BM
authors.lastname: Calija
authors.forename: D S
authors.initials: DS
authors.lastname: Nenadić
authors.forename: A M
authors.initials: AM
authors.lastname: Knezević
authors.forename: M D
authors.initials: MD
authors.lastname: Borzanović
authors.forename: B M
authors.initials: BM
authors.lastname: Krivokapić
authors.forename: I M
authors.initials: IM
authors.lastname: Petrović
authors.forename: B P
authors.initials: BP
authors.lastname: Djukanović
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002809:Chondroitin Sulfates / Q000627:therapeutic use; D003871:Dermatan Sulfate / Q000627:therapeutic use; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006494:Heparin Antagonists / Q000627:therapeutic use; D006497:Heparan Sulfate / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006493:Heparin; D006494:Heparin Antagonists; D006497:Heparan Sulfate; C035838:danaparoid