CuBr-mediated oxyalkylation of vinylarenes under aerobic conditions via cleavage of sp3 C-H bonds alpha to oxygen.
A novel difunctionalization reaction of vinylarenes with cyclic ethers has been developed by copper catalysis via direct activation of alpha-sp(3) C-H bonds of oxygen in the presence of 1-1.2 equiv of TBHP under mild aerobic conditions. The reaction shows excellent regioselectivities and good functional group tolerance to give the oxyalkylated products of vinylarenes.
Cheng
Kai
K
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
Huang
Lehao
L
Zhang
Yuhong
Y