title: [Analyses of the results in the treatment of locally advanced hypopharyngeal carcinoma with different therapeutic approach].
abstract: BACKGROUND
  treatment of locoregional advanced hypopharyngeal cancers of grades III and IV would be surgery and/or radiotherapy. An increasing number of authors has emphasized favorable effects of neoadjuvant chemotherapy and radiotherapy with potentiation.
  
  
  OBJECTIVE
  the authors presented therapeutical results of three-year survived patients with squamocellular cancers of the hypopharynx (SCC Hy), grades III and IV, in relation to specific modalities of therapeutical approach.
  
  
  METHODS
  a series of 207 patients with grades III and IV of SCC Hy, treated in the period 1982 to 2002, was analyzed. Group I consisted of 131 patients who had surgery and postoperative radiotherapy (SUR-RT). Group II included 16 patients who underwent induction chemotherapy, surgery and postoperative radiotherapy (IC-SUR-RT). Group III consisted of 60 patients, who had primary radiotherapy (RT). Group IV involved 29 patients who were treated, in the period 2003-2006, by neoadjuvant chemotherapy followed by radiotherapy with potentiation (CHT-RT).
  
  
  RESULTS
  three-year survival in Group I was 67.94%, Group II--50%, Group III--30%, and in Group IV was 51.72%. Five-year survival was analyzed only in group I-III. The longest survival was observed in Group I--33.59%.
  
  
  CONCLUSIONS
  the best therapeutical results were achieved in patient group that was primarily operated on and then had postoperative radiotherapy, while the worst survival was recorded in patients who had primary radiotherapy.
authors.affiliation: Institut za otorinolaringologiju i naksilofacijalnu hirurgiju, KC Srbije, Beograd.
authors.forename: A
authors.initials: A
authors.lastname: Mikić
authors.forename: I
authors.initials: I
authors.lastname: Pendjer
authors.forename: Z
authors.initials: Z
authors.lastname: Dudvarski
authors.forename: A
authors.initials: A
authors.lastname: Trivić
authors.forename: M
authors.initials: M
authors.lastname: Hirurgiju
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate