[The diagnosis of anthracycline-induced cardiac damage and heart failure].
Routine examinations during chemotherapy containing anthracyclines evaluate heart function before treatment and monitor cardiotoxic effects during and after therapy. A number of methods are useful in cardiac assessment, including electrocardiography, radiology techniques (RTG, CT, MRI,PET-CT, PET-MRI), echocardiography, radioisotope imaging techniques (scintigraphy, MUGA,PET), and ultra-structure evaluation in biopsy samples. Nevertheless, there is a continuous need for new methods to predict future damage at the initial stages of cardiac changes. In recent years the therapeutic usefulness of biochemical blood parameters in anthracycline-treated patients has been assessed. The levels of cardiac troponins (cTnI, cTnT), natriuretic peptides (ANP, BNP), and endothelin 1 have been included in the studies. Heart-type fatty acid binding protein (H-FABP) is another promising factor showing cardiomyocytic impairment. However, the clinical use of biochemical parameters in diagnosing anthracycline-related cardiotoxicity is still a controversial issue.
Dudka
Jarosław
J
Katedra i Zakład Patomorfologii Klinicznej, UM w Lublinie, 20-950 Lublin. ave123@wp.pl
Burdan
Franciszek
F
Korga
Agnieszka
A
Dyndor
Katarzyna
K
Syroka
Iwona
I
Zieba
Justyna
J
Lewkowicz
Dorota
D
Korobowicz-Markiewicz
Agnieszka
A
D018943:Anthracyclines / Q000009:adverse effects*; D054715:Cardiotoxins / Q000009:adverse effects*; D016232:Endothelins / Q000097:blood; D006333:Heart Failure / Q000097:blood / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D045265:Natriuretic Peptides / Q000097:blood; D014336:Troponin / Q000097:blood
D018943:Anthracyclines; D054715:Cardiotoxins; D016232:Endothelins; D045265:Natriuretic Peptides; D014336:Troponin