title: Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge.
abstract: Necrotizing sialometaplasia is a benign, self-limiting, inflammatory process involving salivary glands, commonly associated with tissue ischemia. Clinically, necrotizing sialometaplasia is most often found in the hard palate as a deep ulcer with raised, indurated edges that can be indolent. This, as well as the histopathologic findings of necrotizing sialometaplasia, can be confused with those of a malignant neoplasm. We report a rare case of necrotizing sialometaplasia in the larynx, probably initiated by an underlying malignant process. We suggest an aggressive diagnostic approach, when necrotizing sialometaplasia involves the larynx and no recent exposure to radiation, surgery or trauma has been recorded. Necrotizing sialometaplasia of the larynx should be regarded as secondary to malignancy until proven otherwise.
authors.affiliation: Department of Otolaryngology, Head-and Neck Surgery, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark. atravn@hotmail.com
authors.forename: Tomaas
authors.initials: T
authors.lastname: Ravn
authors.forename: Waldemar
authors.initials: W
authors.lastname: Trolle
authors.forename: Katalin
authors.initials: K
authors.lastname: Kiss
authors.forename: Viggo Hulthin
authors.initials: VH
authors.lastname: Balle
mesh_terms: D000328:Adult; D001706:Biopsy; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis* / Q000473:pathology; D015897:Comorbidity; D003937:Diagnosis, Differential; D004825:Epiglottis / Q000473:pathology; D005260:Female; D006801:Humans; D007013:Hypopharynx / Q000473:pathology; D007818:Laryngeal Diseases / Q000175:diagnosis* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D007828:Laryngoscopy; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness; D012797:Sialometaplasia, Necrotizing / Q000175:diagnosis* / Q000473:pathology; D014827:Vocal Cords / Q000473:pathology