title: European rabbits (Oryctolagus cuniculus) are naturally infected with different Trypanosoma cruzi genotypes.
abstract: Trypanosoma cruzi, the etiologic agent of Chagas disease, presents a complex life cycle, cycling between reduviid vectors and wild and domestic mammals. The European rabbit is an introduced species in America, but its role as reservoir in the wild transmission cycle of Chagas disease remains unknown. We used polymerase chain reaction, Southern blot, and hybridization tests to detect infection and characterize genotypes in rabbits from a hyperendemic area of Chagas disease in Chile. Results show 38% of infection with different genotypes. We provide evidence that rabbits are naturally infected with T. cruzi, which may have important epidemiologic consequences for the wild transmission cycle.
authors.affiliation: Departamento de Ciencias Ecológicas, Facultad de Ciencias, Universidad de Chile, Santiago, Chile. cbotto@uchile.cl
authors.forename: Carezza
authors.initials: C
authors.lastname: Botto-Mahan
authors.forename: Mariana
authors.initials: M
authors.lastname: Acuña-Retamar
authors.forename: Ricardo
authors.initials: R
authors.lastname: Campos
authors.forename: Pedro E
authors.initials: PE
authors.lastname: Cattan
authors.forename: Aldo
authors.initials: A
authors.lastname: Solari
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000453:epidemiology / Q000469:parasitology / Q000662:veterinary*; D002677:Chile / Q000453:epidemiology; D004197:Disease Reservoirs / Q000469:parasitology*; D005838:Genotype; D011817:Rabbits / Q000469:parasitology*; D014349:Trypanosoma cruzi / Q000145:classification / Q000235:genetics*