Chemical constituents from the aerial parts of Artemisia minor.
Four new compounds including three bicoumarins, arteminorins A-C (1-3), and one neolignan, arteminorin D (4), together with 31 known ones were isolated from the aerial parts of Artemisia minor. Their structures were established on the basis of spectroscopic data and comparison with those of the related known compounds. Ethyl caffeate (27) showed in vitro cytotoxicity against the HepG2 cancer cell line. Arteminorin C (3) and luteolin (19) showed inhibitory activity on xanthine oxidase (XOD), and caffeic acid (28) exhibited inhibitory activity on protein tyrosine phosphatase 1B (PTP1B).
He
Zhi-Zhou
ZZ
National Engineering Research Center for Natural Medicines, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People's Republic of China.
Yan
Ju-Fang
JF
Song
Zhi-Jun
ZJ
Ye
Fei
F
Liao
Xun
X
Peng
Shu-Lin
SL
Ding
Li-Sheng
LS
D019306:Artemisia / Q000737:chemistry*; D002109:Caffeic Acids / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D018609:Tibet; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D002109:Caffeic Acids; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D017705:Lignans; C542213:arteminorin A; C542214:arteminorin B; C542215:arteminorin C; C542216:arteminorin D; D014969:Xanthine Oxidase; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1