title: Brucellosis presenting as myelofibrosis: first case report.
abstract: We describe the case of a 29-year-old woman who presented with pancytopenia and myelofibrosis. Brucella melitensis was identified in her blood. The patient recovered completely with doxycycline and rifampin. A repeat bone marrow biopsy showed hypercellularity without myelofibrosis. Bone marrow findings in cases of pancytopenia due to brucellosis reveal normocellularity, hypercellularity, hemophagocytosis, or granuloma. To our knowledge this is the first report of brucellosis causing myelofibrosis. Brucellosis should be considered as a possible cause of myelofibrosis in endemic areas.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Jordan University Hospital, PO Box 13046, Amman 11942, Jordan. fbakri@yahoo.com
authors.forename: Faris G
authors.initials: FG
authors.lastname: Bakri
authors.forename: Nazzal M
authors.initials: NM
authors.lastname: Al-Bsoul
authors.forename: Ahmad Y
authors.initials: AY
authors.lastname: Magableh
authors.forename: Asem
authors.initials: A
authors.lastname: Shehabi
authors.forename: Musleh
authors.initials: M
authors.lastname: Tarawneh
authors.forename: Azmy M
authors.initials: AM
authors.lastname: Al-Hadidy
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Abu-Fara
authors.forename: Abdallah S
authors.initials: AS
authors.lastname: Awidi
mesh_terms: D000328:Adult; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D017347:Brucella melitensis / Q000145:classification / Q000302:isolation & purification*; D002006:Brucellosis / Q000150:complications* / Q000382:microbiology; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010198:Pancytopenia / Q000209:etiology / Q000382:microbiology; D055728:Primary Myelofibrosis / Q000209:etiology* / Q000382:microbiology; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D004318:Doxycycline; D012293:Rifampin