title: Syndrome of inappropriate antidiuretic hormone secretion possibly associated with amantadine therapy in Parkinson disease.
abstract: OBJECTIVE
  To report a patient who developed a syndrome of inappropriate antidiuretic hormone secretion (SIADH) related with amantadine therapy.
  
  
  METHODS
  A 66-year-old woman, diagnosed with Parkinson disease, developed asthenia, anorexia, weight loss, lethargy and feeling of muscle weakness, and severe hyponatremia, with diagnostic criteria for SIADH, after exposure to amantadine. After amantadine withdrawal, these symptoms disappeared, and sodium levels reached normal values gradually.
  
  
  CONCLUSIONS
  The SIADH should be taken into account among the possible side effects of amantadine.
authors.affiliation: Department of Medicine-Neurology, Hospital Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Hortensia
authors.initials: H
authors.lastname: Alonso Navarro
authors.forename: Angel
authors.initials: A
authors.lastname: Sánz-Aiz
authors.forename: Laura
authors.initials: L
authors.lastname: Izquierdo
authors.forename: Félix Javier
authors.initials: FJ
authors.lastname: Jiménez Jiménez
mesh_terms: D000368:Aged; D000547:Amantadine / Q000009:adverse effects*; D000978:Antiparkinson Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D010300:Parkinson Disease / Q000188:drug therapy; D012964:Sodium / Q000652:urine
chemical_list: D000978:Antiparkinson Agents; D012964:Sodium; D000547:Amantadine