Later onset of herpes zoster-associated immune reconstitution inflammatory syndrome.
OBJECTIVE
The aim of the study was to determine whether immune reconstitution inflammatory syndrome (IRIS) associated with herpes zoster occurs on a different time frame from other instances of IRIS.


METHODS
Statistical analysis of onset times of herpes zoster-associated IRIS and other cases of IRIS was carried out in a retrospective cohort starting antiretroviral therapy at advanced stages of HIV infection.


RESULTS
Herpes zoster-associated IRIS was significantly more frequent after the first 3 months of successful highly active antiretroviral therapy (HAART), than other instances of IRIS (IRIS associated with tuberculosis, Mycobacterium avium complex, Kaposi's sarcoma, etc.) which mainly occurred during the first 3 months of treatment.


CONCLUSIONS
The characteristic onset time pattern of herpes zoster-associated IRIS, coincident with the second phase of immune recovery under HAART, suggests that the immune recovery events underlying herpes zoster-associated IRIS are different from those underlying other types of IRIS. Our findings may be useful in improving the follow-up of individuals who start HAART at an advanced stage of HIV infection.
Espinosa
E
E
Centre for Infectious Diseases Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 4502, 14080 Mexico. reyesteran@cieni.org.mx
Peña-Jiménez
A
A
Ormsby
C E
CE
Vega-Barrientos
R
R
Reyes-Terán
G
G
D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006562:Herpes Zoster / Q000276:immunology*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000276:immunology*; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult
D019380:Anti-HIV Agents