title: [Mechanisms of a serotoninergic syndrome development].
abstract: Mechanism of a serotoninergic syndrome development in the heart, vessels, broncho-pulmonary system, gastrointestinal tract, urogenital system is characterized. Serotonin modulates growth factors and metalloproteinases expression, and influence edema, fibrosis and proliferation development. The role of serotonin in the ontogenesis of heart, the development of liver fibrosis and ulcerative colitis is discussed. The results of own research on serotoninergic syndrome in liver, kidneys and heart tissues presented.
authors.forename: A E
authors.initials: AE
authors.lastname: Lychkova
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000378:metabolism; D055513:Connective Tissue Growth Factor / Q000096:biosynthesis; D003603:Cytotoxins / Q000378:metabolism; D004487:Edema / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000096:biosynthesis; D041981:Gastrointestinal Tract / Q000378:metabolism; D015432:Glomerulonephritis, Membranoproliferative / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000096:biosynthesis; D011817:Rabbits; D051381:Rats; D012137:Respiratory System / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D020230:Serotonin Syndrome / Q000378:metabolism*; D016211:Transforming Growth Factor alpha / Q000096:biosynthesis
chemical_list: D003603:Cytotoxins; D016211:Transforming Growth Factor alpha; D055513:Connective Tissue Growth Factor; D012701:Serotonin; D004815:Epidermal Growth Factor; D020782:Matrix Metalloproteinases