title: Medulloblastoma in a child with down syndrome: long-term remission with multimodality treatment.
abstract: A 4(3/4)-year-old male with Down syndrome (DS) presented with unsteady gait and fatigue. Neuroimaging revealed a cerebellar mass with concomitant obstructive hydrocephalus and additional metastatic lesions. He was successfully treated and is still in complete remission 5 years from diagnosis. The present case illustrates that, although not yet reported, medulloblastoma can also occur in patients with DS.
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria. martin.benesch@klinikum-graz.at
authors.forename: Martin
authors.initials: M
authors.lastname: Benesch
authors.forename: Andrea
authors.initials: A
authors.lastname: Moser
authors.forename: Petra
authors.initials: P
authors.lastname: Sovinz
authors.forename: Herwig
authors.initials: H
authors.lastname: Lackner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schwinger
authors.forename: Hans
authors.initials: H
authors.lastname: Eder
authors.forename: Christian
authors.initials: C
authors.lastname: Urban
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000175:diagnosis / Q000628:therapy*; D012074:Remission Induction