Retrofitting fat metabolism.
In this issue of Cell Metabolism, Liao and colleagues have applied a novel synthetic approach to fight obesity in animals by engineering the plant glyoxylate shunt in vivo (Dean et al., 2009). The idea of introducing an entirely foreign metabolic pathway opens up opportunities for understanding metabolism and creating novel potential therapeutic approaches.
Pei
Liming
L
Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Evans
Ronald M
RM
D000105:Acetyl Coenzyme A / Q000378:metabolism; D045744:Cell Line, Tumor; D005227:Fatty Acids / Q000378:metabolism*; D005943:Gluconeogenesis; D006038:Glyoxylates / Q000378:metabolism; D006801:Humans; D007522:Isocitrate Lyase / Q000235:genetics / Q000378:metabolism; D008292:Malate Synthase / Q000235:genetics / Q000378:metabolism; D010168:Palmitates / Q000378:metabolism
D005227:Fatty Acids; D006038:Glyoxylates; D010168:Palmitates; D000105:Acetyl Coenzyme A; D008292:Malate Synthase; D007522:Isocitrate Lyase; C031150:glyoxylic acid