title: Validation of the IOF quality of life questionnaire for patients with wrist fracture.
abstract: BACKGROUND
  Wrist fracture causes pain and decreased physical, social and emotional function. The International Osteoporosis Foundation has developed a specific questionnaire to assess quality of life in patients with wrist fracture. This questionnaire, including 12 questions, was validated in a multicentre study and compared with an osteoporosis-specific questionnaire (Qualeffo-41) and a generic questionnaire (EQ-5D).
  
  
  METHODS
  The study included 105 patients with a recent wrist fracture and 74 sex- and age-matched control subjects. The questionnaire was administered as soon as possible after the fracture, at 6 weeks, 3 months, 6 months and 1 year after the fracture. Test-retest reproducibility, internal consistency and sensitivity to change were assessed.
  
  
  CONCLUSIONS
  The results showed adequate repeatability and internal consistency of the International Osteoporosis Foundation (IOF) wrist fracture questionnaire. The discriminatory capacity between patients and control subjects was very high, with significant odds ratios for each question and domain. The IOF-wrist fracture questionnaire domain scores showed significant improvement after 3 and 6 months and some improvement from 6 months up to 1 year. The sensitivity to change was much higher for the IOF-wrist fracture total score than for Qualeffo-41 and EQ-5D.
  
  
  CONCLUSIONS
  In conclusion, the IOF-wrist fracture questionnaire appears to be a reliable and responsive quality of life questionnaire.
authors.affiliation: Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands. p.lips@vumc.nl
authors.forename: P
authors.initials: P
authors.lastname: Lips
authors.forename: K
authors.initials: K
authors.lastname: Jameson
authors.forename: M L
authors.initials: ML
authors.lastname: Bianchi
authors.forename: S
authors.initials: S
authors.lastname: Goemaere
authors.forename: S
authors.initials: S
authors.lastname: Boonen
authors.forename: J
authors.initials: J
authors.lastname: Reeve
authors.forename: J
authors.initials: J
authors.lastname: Stepan
authors.forename: O
authors.initials: O
authors.lastname: Johnell
authors.forename: N M
authors.initials: NM
authors.lastname: van Schoor
authors.forename: E
authors.initials: E
authors.lastname: Dennison
authors.forename: J A
authors.initials: JA
authors.lastname: Kanis
authors.forename: C
authors.initials: C
authors.lastname: Cooper
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058866:Osteoporotic Fractures / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D011788:Quality of Life; D014954:Wrist Injuries / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*