title: Intrathecal humoral responses are inversely associated with the frequency of simian immunodeficiency virus macrophage-tropic variants in the central nervous system.
abstract: Sustained simian immunodeficiency virus (SIV) infection of the central nervous system (CNS) depends on macrophage-tropic (M-tropic) strains that are often easily neutralizable. The CNS is often thought of as an immunologically privileged site that fosters replication of M-tropic quasispecies. Yet, there are limited data addressing the intrathecal antibody response or the role of the humoral response, in general, to control M-tropic strains. We investigated the temporal course of the intrathecal fusion inhibitory activity against an M-tropic viral variant and found an inverse relationship between the magnitude of this neutralization and the prevalence of M-tropic populations. These studies suggest a role for the humoral response in the suppression of M-tropic viral species in the CNS in experimental SIV infection.
authors.affiliation: Department of Neurology, University of Pennsylvania, Philadelphia, 19104-4283, USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Ryzhova
authors.forename: Pyone
authors.initials: P
authors.lastname: Aye
authors.forename: Tom
authors.initials: T
authors.lastname: Harvey
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.forename: Andrew
authors.initials: A
authors.lastname: Lackner
authors.forename: Francisco
authors.initials: F
authors.lastname: González-Scarano
mesh_terms: D000818:Animals; D000917:Antibody Formation; D002490:Central Nervous System / Q000276:immunology* / Q000821:virology; D004195:Disease Models, Animal; D006678:HIV / Q000235:genetics / Q000276:immunology; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D006801:Humans; D007278:Injections, Spinal; D008253:Macaca mulatta; D008264:Macrophages / Q000276:immunology* / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*; D013131:Spine / Q000276:immunology* / Q000821:virology
chemical_list: D015483:HIV Antibodies