title: Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM.
abstract: The association of the Ser326Cys polymorphism of the 8-oxoguanine glycosylase 1 (OGG1) gene with type 2 diabetes was examined using a Japanese population (n (M/W): 4585 (2085/2500); age: 62.6 +/- 10.9 years). HbA1c levels and frequency of diabetic subjects were significantly higher in subjects with genotypes with Cys allele than in those without (p = 0.032 and 0.037, respectively). Multiple logistic regression analysis showed that genotypes with Cys allele were significantly associated with diabetes (OR: 1.32, p = 0.0289). In subjects whose glucose tolerance was classified by FPG and 2-h PG (n = 1.634), the association was more substantial (genotypes with Cys allele vs. without, OR: 1.70, p = 0.0059; genotypes Cys/Cys vs. Ser/Ser, OR: 2.19, p = 0.0008). In subjects with genotype Ser/Ser, the insulin secretion index, HOMA-beta, increased in the subjects with glucose intolerance and decreased in the subjects with diabetes, while, in subjects with genotypes Ser/Cys + Cys/Cys, HOMA-beta decreased as the glucose tolerance progressed (p for trend = 0.010).
authors.affiliation: Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan. mdaimon@med.id.yamagata-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Daimon
authors.forename: Toshihide
authors.initials: T
authors.lastname: Oizumi
authors.forename: Sayumi
authors.initials: S
authors.lastname: Toriyama
authors.forename: Shigeru
authors.initials: S
authors.lastname: Karasawa
authors.forename: Yumi
authors.initials: Y
authors.lastname: Jimbu
authors.forename: Kiriko
authors.initials: K
authors.lastname: Wada
authors.forename: Wataru
authors.initials: W
authors.lastname: Kameda
authors.forename: Shinji
authors.initials: S
authors.lastname: Susa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Muramatsu
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D003545:Cysteine / Q000235:genetics; D045647:DNA Glycosylases / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012694:Serine / Q000235:genetics
chemical_list: D007328:Insulin; D012694:Serine; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human; D003545:Cysteine