[Nephrogenic systemic fibrosis: a severe complication of use to gadolinium in patients with kidney failure].
Nephrogenic systemic fibrosis (NSF), also known as nephrogenic fibrosing dermopathy (NFD), is a condition that has occurred only in patients with renal insufficiency. Besides lesions of the skin, this syndrome include fibrosis of skeletal muscle, joints, liver, lung, and heart, with possible fatal outcomes. This disease was first described in 1997 and several reports described the development of NSF after the exposure to gadolinium-based magnetic resonance imaging contrast agents. This review aims to alert physicians and nephrologists about this new pathology that affects patients with renal dysfunction, describing its demographic and epidemiologics aspects, clinic presentation, diagnosis and prognosis, beyond options to prevent and current treatment. We concluded that in all patient with elevated serum creatinine physicians should estimade his kidney function (creatinine clearence) in order to safety of magnetic resonance.
Mundim
Juliano Sacramento
JS
Hospital Municipal de São José dos Campos, SP.
Lorena
Sabrina de Castro
Sde C
Abensur
Hugo
H
Elias
Rosilene Motta
RM
Moysés
Rosa Maria Affonso
RM
Castro
Manuel Carlos Martins de
MC
Romão Júnior
João Egídio
JE
D003287:Contrast Media / Q000009:adverse effects* / Q000493:pharmacokinetics; D005682:Gadolinium / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D054989:Nephrogenic Fibrosing Dermopathy / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D051437:Renal Insufficiency / Q000473:pathology
D003287:Contrast Media; D005682:Gadolinium