Synthesis and antinociceptive activity of pyrazolyl isoxazolines and pyrazolyl isoxazoles.
Pyrazolyl isoxazolines and isoxazoles were synthesised in moderate to good yields using 1,3-dipolar cycloaddition of pyrazole derived nitrile oxide with various dipolarophiles such as N-substituted maleimide, diethylacetylene dicarboxylate and phenylacetylene. The synthesized compounds were evaluated for antinociceptive activities. The 3-pyrazolyl-4,5-dicarbethoxy isoxazoles (9a-c) exhibited the maximum antinociceptive activity.
Karthikeyan
K
K
Organic Chemistry Division, Central Leather Research Institute, Adyar, Chennai 600 020, India.
Veenus Seelan
T
T
Lalitha
K G
KG
Perumal
P T
PT
D000284:Administration, Oral; D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D003500:Cyclization; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
C542837:3-pyrazolyl-4,5-dicarbethoxy isoxazole; D000700:Analgesics; D007555:Isoxazoles; D011720:Pyrazoles