title: Targeting vectors for cancer gene therapy.
abstract: Establishment of a system that allows selective gene transfer to a tumor is expected to enable targeted therapy. Using a combination of fiber-modified adenovirus and antibody to a cell surface antigen, we have explored methods to enhance the selectivity of gene transfer. In addition, we aimed to establish a systematic screening method to search for antibody and cell surface target candidates for providing highly selective gene transfer to a variety of malignant tumors.
authors.affiliation: Department of Molecular Medicine, Sapporo Medical University, Sapporo, Japan.
authors.forename: Kiminori
authors.initials: K
authors.lastname: Nakamura
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kato
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hamada
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000595:Amino Acid Sequence; D000954:Antigens, Surface / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics / Q000627:therapeutic use*; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*
chemical_list: D000954:Antigens, Surface