[What is new in the treatment of vitiligo].
BACKGROUND
Vitiligo is a frequent hypomelanosis that affects 1% of the world population, and 0,95% of the tunisian population.


OBJECTIVE
The objective of our study is to describe through a recent review of the literature, the different therapeutic modalities, now used in vitiligo. We have used a clinical approch to guid therapeutic indications.


METHODS
We have performed a review of the articles, dealing with the treatment of vitiligo and published during the 10 previous years. We have used a Medline research with these key-words: "vitiligo and treatment". Randomized studies were privileged and 29 articles were analysed. We have initially presented all validated therapeutic means now used in vitiligo. We have then proposed, according to this recent review of the literature, clinical indications according to vitiligo type, extension of lesions and if vitiligo involves adults or children.


RESULTS
We dispose of multiple chemical, physical and surgical treatments of vitiligo. Vitiligo with partial melanocyte defect can be treated especially by the different modalities of phototherapy (PUVAtherapy, PUVASOL, UVB therapy TL01, Laser excimer). Surgical treatments were also described, with there principal indications. Ethiopathgenic treatments (local steroids, Tacrolimus, Calcipotriol, Vitix*) were especially indicated in vitiligo with complete epidermic and follicular achromy. Finally, different therapeutic associations were reported in the litterature, showing synergic effect of some treatments.


CONCLUSIONS
Phototherapy remains the best treatment of vitiligo type I. In vitiligo type II and III, ethiopathogenic treatments may be efficient, alone or associated with phototherapy.
Khaled
Aida
A
Service de Dermatologie hôpital Charles Nicolle de Tunis.
Zeglaoui
Faten
F
Ezzine
Nadia
N
El Fekih
Nadia
N
Fazaa
Becima
B
Kamoun
Mohamed Ridha
MR
D006801:Humans; D014820:Vitiligo / Q000628:therapy*