title: Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities.
abstract: Two new neo-clerodane diterpenoid alkaloids, scutebarbatine O (1) and 6-O-nicotinoylscutebarbatine G (2), were isolated from the whole plant of Scutellaria barbata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1 and 2 showed cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 2.1-5.7 microM.
authors.affiliation: School of Pharmaceutical Science, Yantai University, Yantai, China. daishengjun_9@hotmail.com
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Dai
authors.forename: Wei-Bing
authors.initials: WB
authors.lastname: Peng
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: De-Wu
authors.initials: DW
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D031363:Scutellaria / Q000737:chemistry*
chemical_list: C541315:6-O-nicotinoylscutebarbatine G; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal; C541314:scutebarbatine O