Apoptosis in the colonic crypt, colorectal adenomata, and manipulation by chemoprevention.
This review discusses the biology and the methods of assessment of apoptosis, of which, the monoclonal antibody M30 would seem to be the most useful; the role of apoptosis in the etiology of colorectal cancer; and its use as a marker to monitor the beneficial effects of chemopreventative interventions to reduce the development of colorectal cancer within the context of clinical trials.
West
Nicholas J
NJ
Endoscopy Department, St George's Hospital, London, UK. njw@medix-uk.com
Courtney
Edward D J
ED
Poullis
Andrew P
AP
Leicester
Roger J
RJ
D000236:Adenoma / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D000911:Antibodies, Monoclonal; D017209:Apoptosis / Q000502:physiology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D018890:Chemoprevention / Q000379:methods; D002986:Clinical Trials as Topic; D003106:Colon / Q000378:metabolism / Q000473:pathology; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control*; D006801:Humans; D051379:Mice; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor