title: Parotid mucosa-associated lymphoid tissue lymphoma regression after Helicobacter pylori eradication.
abstract: A 60-year-old woman with Sjögren's syndrome showed recurrence of parotid mucosa-associated lymphoid tissue (MALT) lymphoma with a simultaneous increase of serum sIL-2R antigen levels 10 years after surgical treatment. Helicobacter pylori infection had been detected in the stomach since the beginning of the lymphoma. Although H. pylori was not detected in the recurrent parotid lymphoma, antibiotic therapy contributed not only to successful eradication of gastric H. pylori but also to disappearance of the recurrent lymphoma. Further studies on the mechanisms of occurrence of extragastric MALT lymphomas are needed to establish the treatment of extragastric MALT lymphomas.
authors.affiliation: Department of Otolaryngology, Takii Hospital, Kansai Medical University, Osaka, Japan. iwai@takii.kmu.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwai
authors.forename: Naoto
authors.initials: N
authors.lastname: Nakamichi
authors.forename: Kaori
authors.initials: K
authors.lastname: Nakae
authors.forename: Masaya
authors.initials: M
authors.lastname: Konishi
authors.forename: Muneo
authors.initials: M
authors.lastname: Inaba
authors.forename: Shoichi
authors.initials: S
authors.lastname: Hoshino
authors.forename: Susumu
authors.initials: S
authors.lastname: Baba
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Amakawa
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage; D001707:Biopsy, Needle; D017291:Clarithromycin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D009092:Mucous Membrane / Q000382:microbiology / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D009853:Omeprazole / Q000008:administration & dosage; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000601:surgery; D011877:Radionuclide Imaging / Q000379:methods; D035583:Rare Diseases; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole