title: PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis.
abstract: Prostaglandin endoperoxidase synthase 2 is a key regulator of inflammation and may play a role in prostate carcinogenesis. The polymorphism, -899G>C (rs20417), alters a transcription factor-binding site and is associated with a reduced risk of colorectal adenoma. We tested the hypothesis that rs20417 may influence prostate cancer risk, using a large case-control study (n(cases)=1608, n(controls)=3058). We found no evidence that rs20417 alters prostate cancer risk (odds ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20). A meta-analysis of three studies also found little evidence that rs20417 alters risk (pooled OR(CC & GC v GG)=1.04, 95% CI=0.93-1.17), making it unlikely that rs20417 contributes in any major way to prostate cancer aetiology.
authors.affiliation: Department of Social Medicine, University of Bristol, Bristol, UK.
authors.forename: A
authors.initials: A
authors.lastname: Murad
authors.forename: S J
authors.initials: SJ
authors.lastname: Lewis
authors.forename: G Davey
authors.initials: GD
authors.lastname: Smith
authors.forename: S M
authors.initials: SM
authors.lastname: Collin
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: F C
authors.initials: FC
authors.lastname: Hamdy
authors.forename: D E
authors.initials: DE
authors.lastname: Neal
authors.forename: J
authors.initials: J
authors.lastname: Donovan
authors.forename: R M
authors.initials: RM
authors.lastname: Martin
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human