title: Reduced fluconazole susceptibility of Candida albicans isolates in women with recurrent vulvovaginal candidiasis: effects of long-term fluconazole therapy.
abstract: Fluconazole resistance and resultant failure to control Candida vaginitis (vulvovaginal candidiasis) remains extremely uncommon; however, long-term clinically relevant decrease in fluconazole susceptibility undoubtedly occurs and accompanies prolonged fluconazole chemoprophylaxis. Accordingly, in patients with refractory vaginitis or breakthrough infections due to Candida albicans, in vitro susceptibility testing is essential to optimally manage vaginitis.
authors.affiliation: Detroit Medical Center, Wayne State University, MI, USA.
authors.forename: Zainab
authors.initials: Z
authors.lastname: Shahid
authors.forename: Jack D
authors.initials: JD
authors.lastname: Sobel
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000302:isolation & purification; D002181:Candidiasis, Vulvovaginal / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D005260:Female; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012008:Recurrence; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole