Solubilisation of griseofulvin, quercetin and rutin in micellar formulations of triblock copolymers E62P39E62 and E137S18E137.
The solubilisation of two poorly soluble flavonoids, quercetin and rutin, in micellar solutions of mixtures of a block copolymer of ethylene oxide and styrene oxide (E(137)S(18)E(137)) with one of ethylene oxide and propylene oxide (E(62)P(39)E(62)) has been studied at 25 and 37 degrees C. Solubilisation capacities were higher than those for the model poorly water-soluble drug griseofulvin and comparable with published values for the solubilisation of rutin by beta-cyclodextrin.
Ribeiro
Maria Elenir N P
ME
Department of Organic and Inorganic Chemistry, Polymer Laboratory, Federal University of Ceará, CX 6.021, CEP 60455-760, Fortaleza, Ceará, Brazil.
Vieira
Icaro G P
IG
Cavalcante
Igor Marques
IM
Ricardo
Nágila M P S
NM
Attwood
David
D
Yeates
Stephen G
SG
Booth
Colin
C
D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry; D005027:Ethylene Oxide / Q000737:chemistry; D006118:Griseofulvin / Q000008:administration & dosage / Q000737:chemistry*; D008823:Micelles; D011108:Polymers / Q000737:chemistry*; D011794:Quercetin / Q000008:administration & dosage / Q000737:chemistry*; D012431:Rutin / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry
D000975:Antioxidants; D004852:Epoxy Compounds; D008823:Micelles; D011108:Polymers; D047392:beta-Cyclodextrins; D006118:Griseofulvin; D012431:Rutin; D011794:Quercetin; C013690:styrene oxide; D005027:Ethylene Oxide; C031215:betadex; C009068:propylene oxide