Brucellosis presenting as myelofibrosis: first case report.
We describe the case of a 29-year-old woman who presented with pancytopenia and myelofibrosis. Brucella melitensis was identified in her blood. The patient recovered completely with doxycycline and rifampin. A repeat bone marrow biopsy showed hypercellularity without myelofibrosis. Bone marrow findings in cases of pancytopenia due to brucellosis reveal normocellularity, hypercellularity, hemophagocytosis, or granuloma. To our knowledge this is the first report of brucellosis causing myelofibrosis. Brucellosis should be considered as a possible cause of myelofibrosis in endemic areas.
Bakri
Faris G
FG
Department of Medicine, Division of Infectious Diseases, Jordan University Hospital, PO Box 13046, Amman 11942, Jordan. fbakri@yahoo.com
Al-Bsoul
Nazzal M
NM
Magableh
Ahmad Y
AY
Shehabi
Asem
A
Tarawneh
Musleh
M
Al-Hadidy
Azmy M
AM
Abu-Fara
Mohammed A
MA
Awidi
Abdallah S
AS
D000328:Adult; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D017347:Brucella melitensis / Q000145:classification / Q000302:isolation & purification*; D002006:Brucellosis / Q000150:complications* / Q000382:microbiology; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010198:Pancytopenia / Q000209:etiology / Q000382:microbiology; D055728:Primary Myelofibrosis / Q000209:etiology* / Q000382:microbiology; D012293:Rifampin / Q000627:therapeutic use
D004318:Doxycycline; D012293:Rifampin