title: Myofibroblast transformation in metastatic extramedullary chronic myeloid leukemia: a case report.
abstract: Primary and metastatic carcinomas have a reactive stroma characterized by many myofibroblasts. These cells have also been documented in nonepithelial malignancies, such as sarcomas, malignant melanoma, and lymphoid tumors but in generally far fewer numbers. In non-Hodgkin's lymphoma, Hodgkin's disease, and leukemia, myofibroblasts are rather rarely documented. In particular, there appear to be no reports of myofibroblasts in either primary bone-marrow/peripheral blood leukemia or secondary deposits of leukemia. In this paper, a case of a relapsed chronic myeloid leukemia appearing in an inguinal lymph node is described, containing many myofibroblasts. The case is detailed and presented with a discussion on the role of myofibroblasts in the progression of nonepithelial cancers.
authors.affiliation: Institute of Hematology & Blood Diseases Hospital, Peking Union Medical College, Tianjin, China.
authors.forename: Yong-Xin
authors.initials: YX
authors.lastname: Ru
authors.forename: Brian
authors.initials: B
authors.lastname: Eyden
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Li
authors.forename: Bing-Yu
authors.initials: BY
authors.lastname: Mao
authors.forename: En-Bin
authors.initials: EB
authors.lastname: Liu
authors.forename: Tian-Xiang
authors.initials: TX
authors.lastname: Pang
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000648:ultrastructure*; D018450:Disease Progression; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D008198:Lymph Nodes / Q000648:ultrastructure*; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000648:ultrastructure*; D015388:Organelles / Q000648:ultrastructure; D012008:Recurrence