title: Fluid resuscitation for major burn patients with the TMMU protocol.
abstract: BACKGROUND
  Fluid resuscitation is one of the critical treatments for the major burn patient in the early phases after injury. We evaluated the practice of fluid resuscitation for severely burned patients with the Third Military Medical University (TMMU) protocol, which is most widely used in many regions of China.
  
  
  METHODS
  Patients with major burns (>30% total body surface area (TBSA)) presenting to Southwest Hospital, Third Military Medical University, between January 2005 and October 2007, were included in this study. Fluid resuscitation was initiated by the TMMU protocol.
  
  
  RESULTS
  A total of 71 patients were (46 adults and 25 children) included in this study. All patients survived the first 48 h after injury smoothly and none developed abdominal compartment syndrome or other recognised complications associated with fluid resuscitation. The average quantity of fluid infused was 3.3-61.33% more than that calculated based on the TMMU protocol in both adult and paediatric groups. The average urine output during the first 24h after injury was about 1.2 ml per kg body weight per hour in the two groups, but reached 1.2 ml and 1.7 ml during the second 24h in adult and pediatric groups, respectively.
  
  
  CONCLUSIONS
  This study indicates that the TMMU protocol for fluid resuscitation is a feasible option for burn patients. Individualised resuscitation - guided by the physiological response to fluid administration - is still important as in other protocols.
authors.affiliation: Burn Research Institute, Southwest Hospital, State Key Lab of Trauma, Burn and Combined injury, Third Military Medical University, Chongqing 400038, PR China. logxw@yahoo.com
authors.forename: Gaoxing
authors.initials: G
authors.lastname: Luo
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Peng
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Yuan
authors.forename: Wenguang
authors.initials: W
authors.lastname: Cheng
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Jin
authors.initials: J
authors.lastname: Tang
authors.forename: Yuesheng
authors.initials: Y
authors.lastname: Huang
authors.forename: Mark
authors.initials: M
authors.lastname: Fitzgerald
mesh_terms: D000328:Adult; D001835:Body Weight; D002056:Burns / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D002985:Clinical Protocols; D005240:Feasibility Studies; D005260:Female; D005440:Fluid Therapy / Q000379:methods* / Q000592:standards; D006801:Humans; D008297:Male; D008875:Middle Aged; D014556:Urine