DNA replication as a target of the DNA damage checkpoint.
Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. DNA replication not only has to have high fidelity, but also has to cope with exogenous and endogenous agents that damage DNA during the life cycle of a cell. The DNA damage checkpoint, which monitors and responds to defects in the genome, is critical for the completion of replication. The focus of this review is how DNA replication is regulated by the checkpoint response in the presence of DNA damage and fork stalling agents.
Zegerman
Philip
P
Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.
Diffley
John F X
JF
D000818:Animals; D002453:Cell Cycle; D004249:DNA Damage; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism; D018741:Replication Origin / Q000235:genetics; D000099272:Replisomes
D004259:DNA-Directed DNA Polymerase; D009097:Multienzyme Complexes; D000099272:Replisomes