[Detoxication and anti-inflammatory therapy in the treatment of generalized soft tissue infections].
Treatment results of 276 patients with generalized soft tissue infections are analyzed. Patients were divided in three comparable groups. Clinical effect (oligopeptide and lactoferrin blood concentrations) of intravenous delivered antibiotics and crystalloid solutions with nonsteroid anti-inflammatory drugs (NSAID) was compared with infusions of pent oxyfillin with glucose-potassium solution. Intravenous infusion of 10-12 ml/kg/day crystalloids and glucose-potassium solution showed better detoxication effect then 3-4 ml/kg/day saline with antibiotics combination. The use of pentoxyfillin demonstrated better anti-inflammatory effect then NSAID. Direct correlation between oligopeptide (r=0,89, p<0,05) and lactoferrin (r=0,93, p<0,05) concentrations and time of the systemic inflammatory reaction syndrome reduction was observed, which allowed the use of these substances in treatment efficacy monitoring.
Barkhatova
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D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D000077324:Crystalloid Solutions; D016207:Cytokines / Q000097:blood; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D016166:Free Radical Scavengers / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage*; D007781:Lactoferrin / Q000097:blood; D009842:Oligopeptides / Q000097:blood; D010431:Pentoxifylline / Q000008:administration & dosage*; D011188:Potassium / Q000008:administration & dosage*; D015532:Rehydration Solutions; D012189:Retrospective Studies; D018461:Soft Tissue Infections / Q000097:blood / Q000628:therapy*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000077324:Crystalloid Solutions; D016207:Cytokines; D016166:Free Radical Scavengers; D007552:Isotonic Solutions; D009842:Oligopeptides; D015532:Rehydration Solutions; D007781:Lactoferrin; D005947:Glucose; D011188:Potassium; D010431:Pentoxifylline