[Temporal changes in intraocular pressure during adrenocorticotropic hormone therapy of two cases of West syndrome].
BACKGROUND
Two cases of West syndrome demonstrated changes in intraocular pressure (IOP) associated with adrenocorticotropic hormone (ACTH) therapy.


METHODS
A nine-month-old (Case 1) and a six-month-old (Case 2) female infant were treated for West syndrome. In Case 1, the IOP was 14 mmHg in the right eye and 16 mmHg in the left eye before ACTH therapy was started. Although the IOP did not change at the beginning of the treatment, it rose to 36 mmHg in the right eye and 25 mmHg in the left eye after an increase in ACTH dosage. In Case 2, the IOP was 10 mmHg in the right eye and 9 mmHg in the left eye before ACTH therapy, it increased to 18 mmHg in both eyes after treatment was started. The IOP returned to baseline levels in both cases after ACTH therapy concluded.


CONCLUSIONS
These findings suggest that it is necessary to monitor IOP when ACTH therapy is given to patients with West syndrome.
Kamao
Tomoyuki
T
Department of Ophthalmology, Medicine of Sensory Function, Ehime University Graduate School of Medicine, Japan. t-kamao@m.ehime-u.ac.jp
Mizoue
Shiro
S
Kawasaki
Shiro
S
Ohashi
Yuichi
Y
D000324:Adrenocorticotropic Hormone / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure / Q000187:drug effects*; D013036:Spasms, Infantile / Q000188:drug therapy*
D000324:Adrenocorticotropic Hormone