title: The phenotype and genotype experiment object model (PaGE-OM): a robust data structure for information related to DNA variation.
abstract: Torrents of genotype-phenotype data are being generated, all of which must be captured, processed, integrated, and exploited. To do this optimally requires the use of standard and interoperable "object models," providing a description of how to partition the total spectrum of information being dealt with into elemental "objects" (such as "alleles," "genotypes," "phenotype values," "methods") with precisely stated logical interrelationships (such as "A objects are made up from one or more B objects"). We herein propose the Phenotype and Genotype Experiment Object Model (PaGE-OM; www.pageom.org), which has been tested and implemented in conjunction with several major databases, and approved as a standard by the Object Management Group (OMG). PaGE-OM is open-source, ready for use by the wider community, and can be further developed as needs arise. It will help to improve information management, assist data integration, and simplify the task of informatics resource design and construction for genotype and phenotype data projects.
authors.affiliation: University of Leicester, Department of Genetics, Leicester, UK. ajb97@leicester.ac.uk
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Brookes
authors.forename: Heikki
authors.initials: H
authors.lastname: Lehvaslaiho
authors.forename: Juha
authors.initials: J
authors.lastname: Muilu
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Shigemoto
authors.forename: Takashige
authors.initials: T
authors.lastname: Oroguchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tomiki
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Mukaiyama
authors.forename: Akihiko
authors.initials: A
authors.lastname: Konagaya
authors.forename: Toshio
authors.initials: T
authors.lastname: Kojima
authors.forename: Ituro
authors.initials: I
authors.lastname: Inoue
authors.forename: Masako
authors.initials: M
authors.lastname: Kuroda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizushima
authors.forename: Gudmundur A
authors.initials: GA
authors.lastname: Thorisson
authors.forename: Debasis
authors.initials: D
authors.lastname: Dash
authors.forename: Haseena
authors.initials: H
authors.lastname: Rajeevan
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Darlison
authors.forename: Mark
authors.initials: M
authors.lastname: Woon
authors.forename: David
authors.initials: D
authors.lastname: Fredman
authors.forename: Albert V
authors.initials: AV
authors.lastname: Smith
authors.forename: Martin
authors.initials: M
authors.lastname: Senger
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Naito
authors.forename: Hideaki
authors.initials: H
authors.lastname: Sugawara
mesh_terms: D004247:DNA / Q000235:genetics*; D030541:Databases, Genetic; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype
chemical_list: D004247:DNA