Subtype-specific reduction of olfactory bulb interneurons in Pax6 heterozygous mutant mice.
Interneurons in the olfactory bulb (OB) play essential roles in the processing of olfactory information. They are classified into several subpopulations by the expression of different neurochemical markers. Here we focused on a transcription factor Pax6, and examined its expression and function in distinct subtypes of OB interneurons. We identified Pax6 expression in specific subtypes of interneurons in the external plexiform layer (EPL). The number of these interneuron subtypes was dramatically decreased in Pax6 heterozygous mutant mice. These results indicate that Pax6 is required for differentiation and/or maintenance of EPL interneurons in the adult mouse OB.
Haba
Hasumi
H
Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Nomura
Tadashi
T
Suto
Fumikazu
F
Osumi
Noriko
N
D000818:Animals; D064032:Calbindin 2; D002452:Cell Count; D002454:Cell Differentiation; D019070:Cell Lineage; D005136:Eye Proteins / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D018398:Homeodomain Proteins / Q000378:metabolism*; D007395:Interneurons / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009830:Olfactory Bulb / Q000378:metabolism*; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000378:metabolism*; D010320:Parvalbumins / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism*; D064030:S100 Calcium Binding Protein G / Q000378:metabolism
D064032:Calbindin 2; D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D010320:Parvalbumins; C000605732:Pax6 protein, mouse; D012097:Repressor Proteins; D064030:S100 Calcium Binding Protein G