title: Macular capillary blood flow in patients with diffuse diabetic macular edema without vitreomacular traction.
abstract: BACKGROUND
  To evaluate macular microcirculation in patients with unilateral diffuse diabetic macular edema (DME) in order to determine whether the alteration in macular microcirculation is associated with development of diffuse DME without vitreomacular traction.
  
  
  METHODS
  According to the presence of epiretinal membrane (ERM), 27 patients having unilateral diffuse DME were divided into DME without ERM (non-ERM-DME group, n = 12) and with ERM (ERM-DME group, n = 15). Twelve patients with macular edema associated with unilateral branch vein obstruction (BVO) and 10 nondiabetic healthy subjects were enrolled as controls. Macular blood flow measured by Heidelberg retinal flowmeter was compared between the edematous eye and the nonedematous fellow eye of each patient and between groups. The macular thickness was evaluated with optical coherence tomography.
  
  
  RESULTS
  The mean macular blood flow was significantly higher than that of the contralateral eyes in edematous eyes of non-ERM-DME group (798.8 vs. 379.8 AU, p < 0.001). By contrast, in the ERM-DME group, the mean macular blood flow of DME eyes was similar to that of fellow eyes (575.9 vs. 596.4 AU, p = 0.538). The macular capillary blood flow in patients with BVO was not significantly different compared with nondiabetic controls (p = 0.967).
  
  
  CONCLUSIONS
  The results suggest that the alteration of macular microcirculation may play a role in the pathogenesis of diffuse DME without vitreomacular traction.
authors.affiliation: Department of Ophthalmology, College of Medicine, Seoul National University, Seoul 110-744, Korea.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Se Joon
authors.initials: SJ
authors.lastname: Woo
authors.forename: Youn Jin
authors.initials: YJ
authors.lastname: Ha
authors.forename: Hyeong Gon
authors.initials: HG
authors.lastname: Yu
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002196:Capillaries / Q000502:physiology; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D017078:Laser-Doppler Flowmetry; D008269:Macular Edema / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D012171:Retinal Vessels / Q000502:physiology*; D041623:Tomography, Optical Coherence