title: Associations of coronary artery calcification and carotid intima-media thickness with plasma concentrations of vascular calcification inhibitors in type 2 diabetic patients.
abstract: Vascular calcification is frequently accompanied by intima-media thickening, but the associations among these atherosclerotic features and bone-related peptides in diabetic patients are unclear. We enrolled 168 type 2 diabetic patients and 40 non-diabetic subjects consecutively admitted to our hospital. Mean intima-media thickness (mean-IMT) in common carotid arteries was measured by B-mode ultrasonography. Agatston coronary artery calcium score (CACS) was obtained using multidetector-row computed tomography (MDCT). Plasma bone-related peptides osteopontin and osteoprotegerin levels were measured. Diabetic patients had higher mean-IMT (p=0.0002) and log(CACS+1) (p<0.0001) and similar bone-related peptides compared to non-diabetic subjects. In diabetic patients classified into tertiles according to their CACS levels, those with the highest scores showed the highest mean-IMT (p=0.0004) and bone-related peptides (p<0.05) among the groups. log(CACS+1) and mean-IMT were associated (p<0.0001) and were positively correlated with osteopontin (p<0.01) and osteoprotegerin (p<0.01) in diabetic patients. Multivariate analyses revealed that the significant independent determinants of log(CACS+1) were age, duration of diabetes and osteopontin (p<0.0001) and those of mean-IMT were age, hypertension, osteopontin and osteoprotegerin (p<0.0001), respectively. We have demonstrated that vascular calcification in type 2 diabetic patients is frequently accompanied by intima-media thickening, and osteopontin may act as a vascular calcification inhibitor by increasing intima-media thickness.
authors.affiliation: Department of Diabetes and Endocrinology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Ishiyama
authors.forename: Eiji
authors.initials: E
authors.lastname: Suzuki
authors.forename: Jun
authors.initials: J
authors.lastname: Katsuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Murase
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Tajima
authors.forename: Yukio
authors.initials: Y
authors.lastname: Horikawa
authors.forename: Shinobu
authors.initials: S
authors.lastname: Goto
authors.forename: Tamio
authors.initials: T
authors.lastname: Fujita
authors.forename: Jun
authors.initials: J
authors.lastname: Takeda
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000503:physiopathology*; D002114:Calcinosis / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D053495:Osteopontin / Q000097:blood*; D053244:Osteoprotegerin / Q000097:blood*; D014057:Tomography, X-Ray Computed
chemical_list: D006442:Glycated Hemoglobin; D053495:Osteopontin; D053244:Osteoprotegerin