B7-H1 and CD8+ Treg: the enigmatic role of B7-H1 in peripheral tolerance.
The interaction between B7-H1 (PD-L1) expressed on APC with PD-1 expressed by T cells was shown previously to result in inhibition of T-cell activation and autoimmune diseases. A paper in this issue of the European Journal of Immunology demonstrates that DC B7-H1 expression can in fact enhance autoimmunity, rather than suppress it. Using a model of direct injection of self antigen-loaded DC into the CNS, the authors demonstrate that DC with intact B7-H1 expression exacerbate CNS autoimmune disease. Importantly, the improved disease outcome in animals treated with B7-H1(-/-) DC is a result of a population of CD8(+) Treg cells that expand at the site of autoimmune inflammation.
Waisman
Ari
A
First Medical Department, University Medicine of the Johannes-Gutenberg University of Mainz, Mainz, Germany. Waisman@uni-mainz.de
Yogev
Nir
N
D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D015551:Autoimmunity / Q000276:immunology; D018122:B7-1 Antigen / Q000276:immunology*; D060890:B7-H1 Antigen; D001921:Brain / Q000166:cytology / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D002465:Cell Movement / Q000276:immunology; D049109:Cell Proliferation; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism / Q000637:transplantation; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D006023:Glycoproteins / Q000008:administration & dosage / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology*; D053646:Interleukin-2 Receptor beta Subunit / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000008:administration & dosage / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D061026:Programmed Cell Death 1 Receptor; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
D000954:Antigens, Surface; D051017:Apoptosis Regulatory Proteins; D018122:B7-1 Antigen; D060890:B7-H1 Antigen; C498919:Cd274 protein, mouse; D006023:Glycoproteins; C508022:Il2rb protein, mouse; D053646:Interleukin-2 Receptor beta Subunit; D008562:Membrane Glycoproteins; D063308:Myelin-Oligodendrocyte Glycoprotein; C491383:Pdcd1 protein, mouse; D010446:Peptide Fragments; D010455:Peptides; D061026:Programmed Cell Death 1 Receptor; C445081:myelin oligodendrocyte glycoprotein (35-55)