Degradation of activated protein kinases by ubiquitination.
Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity or expression levels can cause human diseases.
Lu
Zhimin
Z
Department of Neuro-Oncology and Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer, Houston, TX 77030, USA. zhiminlu@mdanderson.org
Hunter
Tony
T
D000818:Animals; D015536:Down-Regulation; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction; D054875:Ubiquitination
D011494:Protein Kinases