title: Localised peripheral primitive neuroectodermal tumour (PNET) of the conjunctiva.
abstract: A 16-year-old male presented with a 3-month history of an asymptomatic, enlarging conjunctival lesion. An excisional biopsy was performed and histologic and immunohistochemical examination showed characteristic features of a peripheral primitive neuroectodermal tumour (PNET) adjacent to a benign compound naevus. FISH analysis, demonstrating a split-signal at 22q12, confirmed the diagnosis. Staging investigations were negative confirming the primary nature of the lesion. The patient was treated with local wide re-excision and chemotherapy. He remains alive and well 29 months after initial resection.
authors.affiliation: Section of Paediatric Oncology, The Institute of Cancer Research & Royal Marsden Hospital, Sutton, Surrey, UK. andrew.moore@icr.ac.uk
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Moore
authors.forename: Peter G
authors.initials: PG
authors.lastname: Wilson
authors.forename: Penny
authors.initials: P
authors.lastname: McKelvie
authors.forename: Jamie
authors.initials: J
authors.lastname: La Nauze
authors.forename: Lawrence W
authors.initials: LW
authors.lastname: Hirst
mesh_terms: D000293:Adolescent; D003230:Conjunctival Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*