title: Molecular determinants of fluoroquinolone antibacterial agents pharmacokinetics.
abstract: This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.
authors.affiliation: Pharmacy, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. dominique.leveque@chru-strasbourg.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Levêque
authors.forename: François
authors.initials: F
authors.lastname: Jehl
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000493:pharmacokinetics*; D001692:Biological Transport; D001711:Biotransformation; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D004347:Drug Interactions; D024841:Fluoroquinolones / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D057093:Orphan Nuclear Receptors / Q000187:drug effects / Q000378:metabolism; D011110:Polymorphism, Genetic
chemical_list: D018528:ATP-Binding Cassette Transporters; D000900:Anti-Bacterial Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D024841:Fluoroquinolones; D057093:Orphan Nuclear Receptors; D003577:Cytochrome P-450 Enzyme System