[The content of protein S-100 and tumor-necrosis factor-alpha in the serum of patients with discirculatory encephalopathy].
To study the content of protein S-100 and tumor-necrosis factor-alpha (TNF-alpha) in the serum of patients with discirculatory encephalopathy (DE), stages I and II, 108 patients have been examined. The diagnosis of vascular damage of the brain has been confirmed by ultrasound and MRI-examination. Patients with DE, stage II, had significantly higher levels of protein S-100 and TNF-alpha (0.764+/-0.021 optical density units (ODU) and 0.797+/-0.039 pg/l, respectively) compared to the control group (0.540+/-0.015 ODU and 0.528+/-0.001 pg/l; p<0.001). Lesser differences were found between patients with stage II and stage I. The levels of protein S-100 and TNF-alpha increased with age and illness duration (p<0.05). The data obtained can be used in diagnostics of chronic cerebral blood circulation disorders and prognosis of disease outcome.
Morozova
Iu A
IuA
Kamchatnov
P R
PR
Akhmetzhanova
L L
LL
D000367:Age Factors; D000368:Aged; D002561:Cerebrovascular Disorders / Q000145:classification / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002908:Chronic Disease; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D009418:S100 Proteins / Q000097:blood*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D014463:Ultrasonography
D009418:S100 Proteins; D014409:Tumor Necrosis Factor-alpha