[Clinical analysis of 120 cases of infective endocarditis].
OBJECTIVE
To improve the diagnosis and treatment of infective endocarditis (IE) by exploring its causes, pathogenic microorganism and clinical characteristics.


METHODS
The clinical data of 120 IE patients treated in Peking Union Medical College Hospital from October 1997 to September 2007 were analyzed retrospectively.


RESULTS
Of the 120 consecutive cases diagnosed as IE according to the Duke's new criteria, 79 were male and 41 female with a average age of (43.2 +/- 16.7) years old. Twelve cases were prosthetic valve endocarditis (PVE) and 108 cases native valve endocarditis (NVE) and there were no previously known heart diseases in 29 of the cases. Seventy-nine of the 108 (73.1%) NVE patients had basic cardiac abnormalities before IE diagnosis, such as congenital cardiovascular disease (30 cases), idiopathic mitral valve prolapse (23 cases) and rheumatic heart disease (11 cases). Fever (100.0%), anemia (54.2%) and embolism (48.3%) were the most common clinical manifestations in the IE development. Of the 83 patients who had a positive blood culture result, Streptococcus viridans (51.8%) was the most common isolated microorganism.


CONCLUSIONS
Congenital cardiovascular diseases and idiopathic mitral valve prolapse are the two most commonly heart diseases in IE. Blood culture and echocardiogram should always be done to exclude IE, especially presenting with fever of unknown reasons.
Lou
Xiu-fen
XF
Department of Infectious Disease, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Yang
De-yan
DY
Liu
Zheng-yin
ZY
Wang
Huan-ling
HL
Li
Tai-sheng
TS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004697:Endocarditis, Bacterial / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014463:Ultrasonography; D055815:Young Adult