Monoclonal antibodies with orthogonal azaspiracid epitopes.
Azaspiracid antibodies: Immunization of azaspiracid immunoconjugates has elicited monoclonal antibodies with distinct epitopes on the marine toxin; this will open the way toward azaspiracid diagnostics and the detection of contaminated shellfish before they can enter the food supply.
Frederick
Michael O
MO
Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
De Lamo Marin
Sandra
S
Janda
Kim D
KD
Nicolaou
K C
KC
Dickerson
Tobin J
TJ
D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000737:chemistry* / Q000378:metabolism; D018796:Immunoconjugates / Q000276:immunology / Q000378:metabolism; D008387:Marine Toxins / Q000032:analysis* / Q000737:chemistry / Q000276:immunology; D051379:Mice; D012758:Shellfish / Q000633:toxicity; D013141:Spiro Compounds / Q000032:analysis* / Q000737:chemistry / Q000276:immunology; D000095702:Polyether Toxins
D000911:Antibodies, Monoclonal; D000939:Epitopes; D018796:Immunoconjugates; D008387:Marine Toxins; D013141:Spiro Compounds; C406592:azaspiracid; D000095702:Polyether Toxins