[Clinical aspect of recent progress in phosphate metabolism. Distribution of phosphorus and its physiological roles in the body: the form, distribution, and physiological function].
Phosphorus plays pivotal roles in the survival such as the cellular structure, genomic information, energy metabolism, and cell signaling. Total amount of phosphorus is 500-700 g in human, most of which is stored in the bone in an insoluble form of calcium salt. About 15% of phosphorus is located in the cell membrane and the intracellular fluid in the soft tissues in a form of organic phosphate. Only 0.1% is present in the extracellular fluid. This phosphate pool plays a role in the dynamic equilibrium through the gut, kidney, bone and other tissues. Most of inorganic phosphates in the extracellular fluid are present in a form of ions such as H2PO4- and HPO(4)2-, and the concentration of phosphatic acids is about 1.2 mM. The form, distribution, and physiological function of phosphorus in the body are summarized in this review.
Yano
Shozo
S
Department of Internal Medicine 1, Shimane University Faculty of Medicine.
Sugimoto
Toshitsugu
T
D001842:Bone and Bones / Q000378:metabolism; D002130:Calcium Phosphates / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003599:Cytoskeleton; D017886:Durapatite / Q000378:metabolism; D004734:Energy Metabolism; D016678:Genome / Q000235:genetics; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism; D010755:Organophosphates / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D015398:Signal Transduction; D014018:Tissue Distribution
D002130:Calcium Phosphates; D010755:Organophosphates; D010758:Phosphorus; D017886:Durapatite; C020243:calcium phosphate