title: Preliminary results of a fine-grain analysis of mood swings and treatment modalities of bipolar I and II patients using the daily prospective life-chart-methodology.
abstract: OBJECTIVE
  The study aimed to increase the knowledge about the detailed course differences between different forms of bipolar disorder.
  
  
  METHODS
  Using the prospective life-chart-clinician version, we compared the fine-grain analysis of mood swings and treatment modalities of 18 bipolar II with 31 bipolar I patients.
  
  
  RESULTS
  During an observational period of a mean of 26 months we observed an increase of euthymic days, and a decrease of (sub)depressive and (hypo)manic days. Days in a (sub)depressed state were more frequent than days of (hypo)mania as well as days of subdepression or hypomania in comparison to days of full-blown depression or mania. Bipolar II patients showed an increase in hypomanic days receiving more frequently antidepressants. Bipolar I patients, with a decrease of manic days, were significantly taking more often mood stabilizers.
  
  
  CONCLUSIONS
  Treatment in a specialized bipolar clinic improves the overall outcome, but bipolar II disorder seems to be still treated sub-optimally with a possible iatrogenic increase of hypomanic days.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilian- University, Munich, Germany. christoph.born@med.uni-muenchen.de
authors.forename: C
authors.initials: C
authors.lastname: Born
authors.forename: N-N
authors.initials: NN
authors.lastname: Seitz
authors.forename: H
authors.initials: H
authors.lastname: Grunze
authors.forename: E
authors.initials: E
authors.lastname: Vieta
authors.forename: S
authors.initials: S
authors.lastname: Dittmann
authors.forename: F
authors.initials: F
authors.lastname: Seemüller
authors.forename: B
authors.initials: B
authors.lastname: Amann
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000145:classification / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D008094:Lithium