title: Tacrolimus ointment: a novel and effective topical treatment of localized atopic dermatitis in a rhesus macaque (Macaca mulatta).
abstract: An adult, male, rhesus macaque presented with pruritus and a focal, exudative, inflamed, erythematous skin lesion of approximately 2 cm in diameter on the ventral aspect of the mandible. The lesion resolved after 10 d of treatment with 1% chlorhexidine solution and triple-antibiotic ointment. However, the skin lesion subsequently recurred several times over a 2-mo period. A punch biopsy was performed, and histological changes were most consistent with a diagnosis of atopic dermatitis. Treatment with topical tacrolimus ointment, an immunosuppressive drug, proved successful in the resolution of all clinical signs after 4 mo. According to a literature review, this article is the first report of the use of tacrolimus ointment as a topical treatment of atopic dermatitis in a rhesus macaque.
authors.affiliation: Department of Comparative Medicine Stanford University, School of Medicine, Stanford, California, USA. storreil@stanford.edu
authors.forename: Stéphanie L
authors.initials: SL
authors.lastname: Torreilles
authors.forename: Richard H
authors.initials: RH
authors.lastname: Luong
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Felt
authors.forename: Diane E
authors.initials: DE
authors.lastname: McClure
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000188:drug therapy* / Q000473:pathology; D009824:Ointments; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus