title: Clinical outcomes of endoscopic submucosal dissection in elderly patients with early gastric cancer.
abstract: OBJECTIVE
  Endoscopic submucosal dissection (ESD) has advantages over conventional endoscopic mucosa resection. The number of elderly patients (more than 75 years old) with early gastric cancer (EGC) has been steadily increasing. We sought to assess clinical outcomes of ESD for EGC in elderly.
  
  
  METHODS
  ESD was performed for patients with EGC, who fulfilled the criteria for ESD: mucosal cancer without ulcer findings irrespective of tumor size; mucosal cancer with ulcer findings 3 cm or less in diameter; and minute submucosal invasive cancer 3 cm or less in size. Two hundred and sixty elderly patients (> or =75 years old) with 279 lesions, and 401 non-elderly patients with 434 lesions were enrolled to this study. The patients underwent ESD and then received periodic endoscopic follow-up and metastatic surveys for 6-89 months (median: 30 months). Resectability (en-bloc or piecemeal resection), curability (curative or noncurative resection), completeness (complete or incomplete resection), complications, and survival rates were assessed.
  
  
  RESULTS
  The one-piece resection rate was significantly lower in elderly patients (93.9%) than in non-elderly patients (97.9%). The complete resection rate was significantly lower in elderly patients (87.4%) than in non-elderly patients (96.6%). Pneumonia, but not bleeding or perforation, developed in association with ESD more frequently in the elderly patients by 2.2%. Local tumor recurrence was quite rare, and the overall and disease-free survival rates were acceptable irrespective of age.
  
  
  CONCLUSIONS
  En-bloc and complete resections were achieved less frequently in elderly patients, but the long-term outcomes in elderly EGC patients may be excellent, and ESD is a feasible treatment in the elderly.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan. hajimei2002@yahoo.co.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Isomoto
authors.forename: Ken
authors.initials: K
authors.lastname: Ohnita
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Fukuda
authors.forename: Kohki
authors.initials: K
authors.lastname: Ikeda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nishiyama
authors.forename: Motohisa
authors.initials: M
authors.lastname: Akiyama
authors.forename: Eisuke
authors.initials: E
authors.lastname: Ozawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
authors.forename: Saburo
authors.initials: S
authors.lastname: Shikuwa
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D004210:Dissection / Q000009:adverse effects / Q000379:methods*; D055088:Early Detection of Cancer; D005240:Feasibility Studies; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery*; D005773:Gastroscopy / Q000009:adverse effects; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D018579:Patient Selection; D018570:Risk Assessment; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome