title: Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
abstract: Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part, through an evolved sensitivity of some peroxiredoxins towards peroxide-mediated inactivation in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of 'typical 2-Cys' peroxiredoxins and of the biological roles played by these important enzymes in oxidative stress and nonstress-related cellular signaling. New evidence suggests localized peroxide buildup plays a role in nonstress-related signaling.
authors.affiliation: Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Hall
authors.forename: P A
authors.initials: PA
authors.lastname: Karplus
authors.forename: Leslie B
authors.initials: LB
authors.lastname: Poole
mesh_terms: D000818:Animals; D002384:Catalysis; D003545:Cysteine / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D018384:Oxidative Stress; D054464:Peroxiredoxins / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D006861:Hydrogen Peroxide; D054464:Peroxiredoxins; D003545:Cysteine