[Imaging of gastrointestinal stromal tumors].
Gastrointestinal stromal tumors (GIST) arising from interstitial cells of Cajal, represent the first type of solid tumor, which is very sensitive to a specific molecularly targeted tyrosine kinase receptor blocker (i. e., imatinib). On CT, which is considered as the reference technique, GISTs typically present as large, well-delineated, heterogeneous and sometimes exophytic masses. In contrast with the absence of lymph node involvement, hepatic metastasis as well as mesenteric involvement can be observed. MR-enteroclysis is indicated to investigate the local extent of the disease in specific cases whereas MR imaging is used to detect hepatic metastasis. Because of a specific treatment, contrast-enhanced imaging is needed for the follow-up of treated tumors. Evaluation of tumor response to treatment is best assessed with CT which still remains the reference imaging technique whereas FDG-PET imaging is used in specific cases.
Bensimhon
D
D
Service de Radiologie Viscérale, Hôpital Lariboisière, AP-HP, GHU Nord et Université Diderot-Paris 7, 75010 Paris.
Soyer
P
P
Boudiaf
M
M
Fargeaudou
Y
Y
Nemeth
J
J
Pocard
M
M
Idy-Peretti
I
I
Dray
X
X
Martin-Grivaud
S
S
Duchat
F
F
Hamzi
L
L
Rymer
R
R
D000328:Adult; D000368:Aged; D000792:Angiography; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D001706:Biopsy; D053704:Capsule Endoscopy; D003287:Contrast Media; D003937:Diagnosis, Differential; D019160:Endosonography; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D000068877:Imatinib Mesylate; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D049268:Positron-Emission Tomography / Q000379:methods*; D011743:Pyrimidines / Q000627:therapeutic use; D012008:Recurrence; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D001549:Benzamides; D003287:Contrast Media; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate