Modulating the release kinetics through the control of the permeability of the layer-by-layer assembly: a review.
The layer-by-layer (LbL) self-assembly technique has emerged as a simple and versatile method for coating biological and non-biological templates for various biomedical applications. A promising avenue of this technique lies in the encapsulation of drugs and other biological substances for controlled release. Fundamental studies of LbL assembly on flat surfaces have provided a sound understanding of film deposition theory and its pertinence to ionic and molecular transport and diffusion through polyelectrolyte multilayer (PEM) films. However, there is a lack of information on the permeability of three-dimensional PEM shell systems. In either PEM films or shells, it has been shown that drug release is a function of the ionic strength, pH and/or multilayer thickness. This report aims to provide an overview of the physicochemical parameters affecting the permeability of two- and three-dimensional multilayer shells, including ionic strength, layer number and pH. Furthermore, their synergic effect on loading and release of biologically active molecules from LbL multilayers are discussed.
Mansouri
Sania
S
McGill University, Department of Biomedical Engineering, Duff Medical Science Building, 3775 University Street, Montreal, QC, H3A 2B4, Canada.
Winnik
Françoise M
FM
Tabrizian
Maryam
M
D000327:Adsorption; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D004573:Electrolytes / Q000493:pharmacokinetics*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008567:Membranes, Artificial; D015394:Molecular Structure; D009994:Osmolar Concentration; D010539:Permeability; D055672:Static Electricity; D013499:Surface Properties
D003692:Delayed-Action Preparations; D004573:Electrolytes; D008567:Membranes, Artificial