The collagen receptor DDR2 is expressed during early cardiac development.
Discoidin Domain Receptor 2 (DDR2) is a receptor tyrosine kinase which has been shown to regulate cell migration upon binding its ligand, collagen. Expression studies determined that DDR2 mRNA and protein are present in the atrioventricular canal during epithelial-mesenchymal transformation (EMT) and the receptor is expressed in both activated endothelial and migrating mesenchymal cells in vivo.
Goldsmith
Edie C
EC
Department of Cell, Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, South Carolina, USA.
Zhang
Xiadong
X
Watson
James
J
Hastings
Josh
J
Potts
Jay D
JD
D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002642:Chick Embryo; D003094:Collagen / Q000378:metabolism*; D000070818:Discoidin Domain Receptors; D054089:Endocardial Cushions / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D004699:Endocardium / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006321:Heart / Q000196:embryology*; D006325:Heart Atria / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D006352:Heart Ventricles / Q000166:cytology / Q000378:metabolism; D008648:Mesoderm / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D038081:Organogenesis / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D038981:Receptors, Collagen / Q000235:genetics / Q000378:metabolism*; D011975:Receptors, Mitogen / Q000235:genetics / Q000378:metabolism*
D038981:Receptors, Collagen; D011975:Receptors, Mitogen; D003094:Collagen; D000070818:Discoidin Domain Receptors; D020794:Receptor Protein-Tyrosine Kinases