Metastatic pancreatic carcinoma presenting as colon carcinoma.
Determining the origin of poorly differentiated adenocarcinomas remains a challenge for the pathologist. This manuscript reports the use of a panel of specific immunohistochemical stains to determine the primary site of a tumor in the colon. A 45-year-old man had a right hemicolectomy for adenocarcinoma. Immunohistochemical staining documented that the lesion was a metastasis from a primary pancreatic adenocarcinoma--an unusual pattern of spread. The case emphasizes the important use of immunohistochemistry in identifying the primary source of lesions, allowing for appropriate treatment and staging.
Bellows
Charles
C
Department of Pathology, Lab Medicine and Surgery, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
Gage
Thomas
T
Stark
Matthew
M
McCarty
Curt
C
Haque
Salima
S
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D018395:CA-19-9 Antigen / Q000378:metabolism; D003082:Colectomy; D003110:Colonic Neoplasms / Q000556:secondary* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*
D018395:CA-19-9 Antigen