title: Adipocytokines, sex hormones, and cardiovascular risk factors in postmenopausal women: factor analysis of the Rancho Bernardo study.
abstract: Steroid sex hormones modulate the expression of adipocytokines implicated in the pathogenesis of athero-thrombotic cardiovascular disease. We used exploratory factor analysis to search for latent associations between circulating sex steroid hormones, adipocytokines, and cardiovascular risk factors in a well-characterized cohort of postmenopausal women. Among participants in the Rancho Bernardo community study we identified 515 Caucasian women with a mean age of 74+/-8 years and mean body mass index of 24.2+/-3.7 kg/m(2). All had intact ovaries and none was using estrogen therapy. We constructed models aiming for structural clarity and high loading of variables on individual factors. Total adiponectin loaded with major lipid subfractions (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and fasting triglycerides) and with sex hormone-binding globulin. Leptin loaded with central obesity (waist circumference) and fasting insulin levels. Neither adipocytokine loaded with total or bioavailable testosterone or with estradiol or dehydroepiandrosterone sulfate. Sex hormones consistently loaded together on a separate factor; this co-segregation was not influenced by body mass index. Exclusion of women with diabetes did not alter these observations. In conclusion, we identified evidence of latent associations between adipocytokines and a range of cardiovascular risk factors in postmenopausal women. Our results suggest that cardiovascular risk in older women may be modulated through a hitherto unrecognized association between adiponectin, lipid subfractions, and sex hormone bioavailability.
authors.affiliation: Division of Epidemiology, Department of Family & Preventive Medicine, University of California, San Diego, La Jolla, California 92093-0607, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Krentz
authors.forename: D
authors.initials: D
authors.lastname: von Mühlen
authors.forename: E
authors.initials: E
authors.lastname: Barrett-Connor
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology*; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D004958:Estradiol / Q000097:blood*; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D017698:Postmenopause; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D015850:Interleukin-6; D020738:Leptin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D002097:C-Reactive Protein; D002784:Cholesterol