title: S100B milk concentration in mammalian species.
abstract: S100B is a neurotrophic protein detectable in biological fluids and in human milk. Since there are several maternal-neonatal conditions requiring the administration of animal milks the aim of the present study was to quantify S100B in milk from different mammalian species and to compare protein's concentration among human and mammalian milks. We assessed S100B concentrations in donkey (n=12), goat (n=15) sheep (n=15), commercially available cow (n=8) and human (n=15) milk samples. S100B measurements were performed using an immunoluminometric assay. S100B concentration in human milk (10.41 +/- 4.2 microg/L) was higher (P LESS THAN0.001) than mammalian milks. Of note, S100B concentration in cow milk (3.13 +/- 0.56 microg/L) was higher (P LESS THAN0.01) than that showed in donkey (1.17 +/- 0.26 microg/L), sheep (0.25 +/- 0.11 microg/L) and goat (0.26 +/- 0.11 microg/L). S100B in donkey milk was higher (P LESS THAN0.01) than sheep and goat samples whilst protein's concentration did not differ between goat and sheep. The present study suggests the opportunity of S100B addition to animal milk intended for infant feeding.
authors.affiliation: Department of Biochemistry, Medical Chemistry and Molecular Biology, University of Catania, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Galvano
authors.forename: Alessandro
authors.initials: A
authors.lastname: Frigiola
authors.forename: Luigi
authors.initials: L
authors.lastname: Gagliardi
authors.forename: Sabina
authors.initials: S
authors.lastname: Ciotti
authors.forename: Matteo
authors.initials: M
authors.lastname: Bognanno
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Iacopino
authors.forename: Francesco
authors.initials: F
authors.lastname: Nigro
authors.forename: Gabriella Lucia
authors.initials: GL
authors.lastname: Tina
authors.forename: Daniela
authors.initials: D
authors.lastname: Cavallaro
authors.forename: Michele
authors.initials: M
authors.lastname: Mussap
authors.forename: Andrea
authors.initials: A
authors.lastname: Piva
authors.forename: Ester
authors.initials: E
authors.lastname: Grilli
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Michetti
authors.forename: Diego
authors.initials: D
authors.lastname: Gazzolo
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D018397:Equidae; D006041:Goats; D006801:Humans; D007118:Immunoassay; D008892:Milk / Q000737:chemistry*; D008895:Milk, Human / Q000737:chemistry*; D009414:Nerve Growth Factors / Q000032:analysis*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis*; D012756:Sheep; D013045:Species Specificity
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human