[Clinical aspect of recent progress in phosphate metabolism. FGF23; physiological action and molecular mechanism in the regulation of phosphate and vitamin D metabolism].
Fibroblast growth factor (FGF) 23 is an endocrine hormone regulating the phosphate and vitamin D metabolism in the normal physiology. Recent studies have revealed that Klotho plays an essential role in FGF23 signaling. Klotho-deficient mice exhibit premature aging-like phenotypes, and therefore, this molecule has provided insights into the molecular mechanism of aging. However, it is suggested that the phenotype of the Klotho-deficient mice results from the disturbance in the phosphate and vitamin D metabolism. The importance of the FGF23/Klotho system thus is evident, but additional questions arose from this new concept.
Shimada
Takashi
T
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, USA.
D000375:Aging / Q000235:genetics / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000737:chemistry / Q000502:physiology*; D005966:Glucuronidase / Q000502:physiology; D006801:Humans; D000090265:Klotho Proteins; D051379:Mice; D008969:Molecular Sequence Data; D010710:Phosphates / Q000378:metabolism*; D015398:Signal Transduction; D014807:Vitamin D / Q000378:metabolism*
C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D010710:Phosphates; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins