Medical treatment of Barrett's esophagus: can it prevent cancer?
The challenge of the title of this article is attention getting. How can medical therapy prevent cancer if anti-reflux surgery cannot prevent the neoplastic progression of Barrett's esophagus? Can anything short of esophagectomy prevent cancer? In the face of the increasing incidence of adenocarcinoma of the esophagus into the twenty-first century, the medical therapy of Barrett's esophagus and its potential role in preventing cancer are explored.
Sampliner
Richard E
RE
Arizona Health Sciences Center, Southern Arizona VA Health Care System, 3601 S 6th Avenue (111G-1), Tucson, AZ 85723, USA.
D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001471:Barrett Esophagus / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D001706:Biopsy; D002471:Cell Transformation, Neoplastic; D003043:Cocarcinogenesis; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D004945:Esophagoscopy; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D015994:Incidence; D008390:Markov Chains; D008403:Mass Screening; D011230:Precancerous Conditions / Q000150:complications / Q000188:drug therapy; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D015996:Survival Rate; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D054328:Proton Pump Inhibitors