title: Do melanoidins induced by topical 9% dihydroxyacetone sunless tanning spray inhibit vitamin d production? A pilot study.
abstract: We report here preliminary pilot study data of the effect of sunless tanning spray with 9% [Correction added after online publication (August 24th, 2009): The concentration of Dihydroxyacetone used in the study was 9% and not 3% as previously stated] dihydroxyacetone (DHA) on 25-hydroxyvitamin D [25(OH)D] serum levels in subjects exposed to controlled amounts of UV-B radiation during April/May in Omaha, NE, 41 degrees N latitude. We found that DHA-induced melanoidins in skin act as a topical sunscreen attenuating the formation of 25(OH)D.
authors.affiliation: Osteoporosis Research Center, Creighton University, Omaha, NE, USA. larmas@creighton.edu
authors.forename: Laura A G
authors.initials: LA
authors.lastname: Armas
authors.forename: Ramon M
authors.initials: RM
authors.lastname: Fusaro
authors.forename: Robert M
authors.initials: RM
authors.lastname: Sayre
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Huerter
authors.forename: Robert P
authors.initials: RP
authors.lastname: Heaney
mesh_terms: D000287:Administration, Topical; D004098:Dihydroxyacetone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D010865:Pilot Projects; D011108:Polymers / Q000008:administration & dosage*; D014807:Vitamin D / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
chemical_list: D011108:Polymers; C011908:melanoidin polymers; D014807:Vitamin D; D004098:Dihydroxyacetone