Three new 7.3',8.5'-connected bicyclo[3.2.1]octanoids and other neolignans from leaves of Nectandra amazonum NEES. (Lauraceae).
Three new 7.3',8.5'-connected (macrophyllin-type) bicyclo[3.2.1]octanoid neolignans (nectamazins A-C, 1-3) were isolated from leaves of Nectandra amazonum NEES., along with seven known neolignans (4-10). The structures of 1-3 were characterized by spectroscopic methods (1D, 2D NMR) and the absolute configuration was assigned on the basis of circular dichroism (CD) spectra supported by nuclear Overhauser effect spectroscopy (NOESY) correlations. The new compounds showed inhibition activity against platelet activating factor (PAF)-induced aggregation of rabbit platelets.
Coy Barrera
Ericsson David
ED
Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Química, Laboratorio de Investigación en Productos Naturales Vegetales, AA 14490, Cra 30 45-03, Ciudad Universitaria, Bogotá D.C., Colombia.
Cuca Suárez
Luis Enrique
LE
D000818:Animals; D002236:Carbohydrate Conformation; D002942:Circular Dichroism; D000431:Ethanol; D020441:Ginkgo biloba / Q000737:chemistry; D066298:In Vitro Techniques; D019770:Lauraceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization
D017705:Lignans; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D012997:Solvents; C541717:nectamazin A; C541718:nectamazin B; C541716:nectamazin C; D000431:Ethanol