[EpCAM a proteolytically cleaved oncogene and an excellent therapeutic target in cancer].
Gires
Olivier
O
Ludwig-Maximilians-University, et Helmholtz Center Munich, Germany. Olivier.gires@med.uni-muenchen.de
D051722:ADAM Proteins / Q000378:metabolism; D000072198:ADAM17 Protein; D000951:Antigens, Neoplasm / Q000235:genetics / Q000502:physiology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D015820:Cadherins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D016503:Drug Delivery Systems; D015195:Drug Design; D000071858:Epithelial Cell Adhesion Molecule; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051821:Lymphoid Enhancer-Binding Factor 1 / Q000096:biosynthesis / Q000235:genetics; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D009857:Oncogenes; D053763:Presenilins / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000502:physiology; D051176:beta Catenin / Q000378:metabolism
D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D015820:Cadherins; D015815:Cell Adhesion Molecules; C499379:EPCAM protein, human; D000071858:Epithelial Cell Adhesion Molecule; C497573:LEF1 protein, human; D051821:Lymphoid Enhancer-Binding Factor 1; D009363:Neoplasm Proteins; D053763:Presenilins; D051176:beta Catenin; D051722:ADAM Proteins; D000072198:ADAM17 Protein