Targeting vectors for cancer gene therapy.
Establishment of a system that allows selective gene transfer to a tumor is expected to enable targeted therapy. Using a combination of fiber-modified adenovirus and antibody to a cell surface antigen, we have explored methods to enhance the selectivity of gene transfer. In addition, we aimed to establish a systematic screening method to search for antibody and cell surface target candidates for providing highly selective gene transfer to a variety of malignant tumors.
Nakamura
Kiminori
K
Department of Molecular Medicine, Sapporo Medical University, Sapporo, Japan.
Kato
Kazunori
K
Tanaka
Toshihiro
T
Hamada
Hirofumi
H
D000256:Adenoviridae / Q000235:genetics; D000595:Amino Acid Sequence; D000954:Antigens, Surface / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics / Q000627:therapeutic use*; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*
D000954:Antigens, Surface