Potential interactions with herbal medications and midazolam.
In the management of patients who require intravenous sedation with midazolam care must be taken if the patient is taking herbal drugs. There is a potential for harmful drug interactions between herbal drugs and midazolam.Assessment of which herbal drugs a patient is taking should be part of the treatment planning stage so interactions can be avoided or anticipated.


CONCLUSIONS
Growing numbers of patients are taking herbal or Chinese medication and may not disclose this to the sedation team. Such drugs have the potential for interactions and can affect induction and recovery from sedation.
Tweddell
Paul
P
Elwick Dental Practice, 4 Elwick Road, Ashford, Kent, UK.
Boyle
Carole
C
D000766:Anesthesia, Dental / Q000009:adverse effects* / Q000379:methods; D018686:Anesthetics, Intravenous / Q000009:adverse effects* / Q000493:pharmacokinetics; D001667:Binding, Competitive; D001682:Biological Availability; D016292:Procedural Sedation / Q000009:adverse effects*; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000493:pharmacokinetics; D018757:GABA Modulators / Q000009:adverse effects* / Q000493:pharmacokinetics; D041743:Herb-Drug Interactions / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008874:Midazolam / Q000009:adverse effects* / Q000493:pharmacokinetics; D010936:Plant Extracts / Q000009:adverse effects* / Q000493:pharmacokinetics
D018686:Anesthetics, Intravenous; D004365:Drugs, Chinese Herbal; D018757:GABA Modulators; D010936:Plant Extracts; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D008874:Midazolam