The effect of dietary selenium supplementation on cadmium  absorption and retention in suckling rats.
Selenium (Se) reduces cadmium (Cd) toxicity in adult animals, but its effects in newborn animals are still unknown. This study investigated Cd (as CdCl2) absorption, distribution, and retention in suckling rats receiving oral Se supplementation (as Na2SeO3) in equimolar doses (8 μmol Cd and/or Se per kg b.w./day). Selenium was given either before and during Cd exposure (Sepre + Cd group; pretreatment group) or only during Cd exposure (Se + Cd group). Rats were treated from postnatal day (PND) 6-14 as follows: controls (H2O, PND 6-14), Se (PND 10-14), Cd (PND 10-14), Sepre + Cd (Se PND 6-14 + Cd PND 10-14) and Se + Cd (Se + Cd PND 10-14). Selenium supplementation, especially pre-treatment, decreased Cd levels in the blood, brain, liver and kidney of suckling rats. Selenium levels in plasma, brain, and kidney also decreased. These findings suggest that higher Se intake could efficiently reduce Cd retention during the suckling period.
Lazarus
Maja
M
Institute for Medical Research and Occupational Health, Zagreb, Croatia. mlazarus@imi.hr
Orct
Tatjana
T
Jurasoviæ
Jasna
J
Blanuša
Maja
M
D000042:Absorption / Q000187:drug effects; D000284:Administration, Oral; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002104:Cadmium / Q000097:blood / Q000633:toxicity*; D019587:Dietary Supplements; D004347:Drug Interactions; D005260:Female; D007668:Kidney / Q000737:chemistry / Q000187:drug effects; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood; D014018:Tissue Distribution / Q000187:drug effects
D002104:Cadmium; D012643:Selenium