MAGE-A antigens in patients with primary oral squamous cell carcinoma.
MAGE-A antigens are only expressed on tumor cells. The aim of this study was to identify their expression in patients with oral squamous cell carcinoma (OSCC). Forty-seven patients with primary OSCC was selected retrospectively. Histo-pathological sections were stained immunohistochemically with MAGE-A antibody 57B. The results were evaluated regarding tumor size (T), lymph-node metastasis (N), blood vessel infiltration (V), lymph vessel infiltration (L), grading (G), and sex. MAGE-A antigens were expressed in 55% of all patients. Expression increased with tumor size (T1 = 56%; T2 = 44%; T3 = 67%; T4 = 71%). Lymph-node metastasis had no influence (N0 and N1 about 50%). Tumors with blood and lymph vessel infiltration had higher expression (V0 = 50%; V1 = 100%; L0 = 46%; L1 = 71%). Less-differentiated tumors showed higher rates (G1 = 50%; G2 = 45%; G3 = 83%). OSCC in men were positive in 62% and in women in 38%. MAGE-A antigens are frequently expressed in OSCC. Their expression seems to increase with tumor dedifferentiation.
Müller-Richter
Urs D A
UD
Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany. mueller_u2@klinik.uni-wuerzburg.de
Dowejko
Albert
A
Peters
Silvia
S
Rauthe
Stephan
S
Reuther
Tobias
T
Gattenlöhner
Stefan
S
Reichert
Torsten E
TE
Driemel
Oliver
O
Kübler
Alexander C
AC
D000951:Antigens, Neoplasm / Q000032:analysis*; D001808:Blood Vessels / Q000276:immunology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology / Q000556:secondary; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000276:immunology / Q000473:pathology; D042601:Lymphatic Vessels / Q000276:immunology / Q000473:pathology; D008297:Male; D058950:Melanoma-Specific Antigens; D009062:Mouth Neoplasms / Q000276:immunology* / Q000473:pathology; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012737:Sex Factors
D000951:Antigens, Neoplasm; C072011:MAGEA1 protein, human; C409589:MAGEA12 protein, human; C072013:MAGEA3 protein, human; C095204:MAGEA4 protein, human; C095203:MAGEA6 protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins