Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study.
BACKGROUND
The incidence of type 1 diabetes in children younger than 15 years is increasing. Prediction of future incidence of this disease will enable adequate fund allocation for delivery of care to be planned. We aimed to establish 15-year incidence trends for childhood type 1 diabetes in European centres, and thereby predict the future burden of childhood diabetes in Europe.


METHODS
20 population-based EURODIAB registers in 17 countries registered 29 311 new cases of type 1 diabetes, diagnosed in children before their 15th birthday during a 15-year period, 1989-2003. Age-specific log linear rates of increase were estimated in five geographical regions, and used in conjunction with published incidence rates and population projections to predict numbers of new cases throughout Europe in 2005, 2010, 2015, and 2020.


RESULTS
Ascertainment was better than 90% in most registers. All but two registers showed significant yearly increases in incidence, ranging from 0.6% to 9.3%. The overall annual increase was 3.9% (95% CI 3.6-4.2), and the increases in the age groups 0-4 years, 5-9 years, and 10-14 years were 5.4% (4.8-6.1), 4.3% (3.8-4.8), and 2.9% (2.5-3.3), respectively. The number of new cases in Europe in 2005 is estimated as 15 000, divided between the 0-4 year, 5-9 year, and 10-14 year age-groups in the ratio 24%, 35%, and 41%, respectively. In 2020, the predicted number of new cases is 24 400, with a doubling in numbers in children younger than 5 years and a more even distribution across age-groups than at present (29%, 37%, and 34%, respectively). Prevalence under age 15 years is predicted to rise from 94 000 in 2005, to 160 000 in 2020.


CONCLUSIONS
If present trends continue, doubling of new cases of type 1 diabetes in European children younger than 5 years is predicted between 2005 and 2020, and prevalent cases younger than 15 years will rise by 70%. Adequate health-care resources to meet these children's needs should be made available.


BACKGROUND
European Community Concerted Action Program.
Patterson
Christopher C
CC
Epidemiology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, UK. c.patterson@qub.ac.uk
Dahlquist
Gisela G
GG
Gyürüs
Eva
E
Green
Anders
A
Soltész
Gyula
G
D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002669:Child Welfare / Q000639:trends*; D002675:Child, Preschool; D017281:Cost of Illness; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D005544:Forecasting; D006285:Health Planning; D006301:Health Services Needs and Demand; D006801:Humans; D015994:Incidence; D007223:Infant; D016013:Likelihood Functions; D016014:Linear Models; D008297:Male; D011159:Population Surveillance; D015995:Prevalence; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D017678:Sex Distribution