title: Dracotanosides A-D, spermidine glycosides from Dracocephalum tanguticum: structure and amide rotational barrier.
abstract: Four new spermidine glycosides, dracotanosides A-D (1-4), have been isolated from Dracocephalum tanguticum. These molecules represent the first spermidine glycosides from this plant genus. The structures, including absolute configurations, were determined by spectroscopic and chemical methods. The amide bond rotational barrier of aglycone 1a was calculated by density functional theory (DFT) computation.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, People's Republic of China.
authors.forename: Shu-Qi
authors.initials: SQ
authors.lastname: Wang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Ren
authors.forename: Feng
authors.initials: F
authors.lastname: Xiang
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Chang-Jun
authors.initials: CJ
authors.lastname: Zhu
authors.forename: Hui-Qing
authors.initials: HQ
authors.lastname: Yuan
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Sun
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Lv
authors.forename: Xue-Jie
authors.initials: XJ
authors.lastname: Sun
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D013095:Spermidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D013095:Spermidine