title: Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation.
abstract: This study characterized the contribution of bone marrow-derived cells to human neoplasia and the perineoplastic stroma. The Australasian Bone Marrow Transplant Recipient Registry was used to identify solid organ neoplasia that developed in female recipients of male allogeneic stem cell transplants. Eighteen suitable cases were identified including several skin cancers, two gastric cancers, and one rectal adenoma. Light microscopy, fluorescence and chromogenic in situ hybridization, and immunohistochemistry were performed to determine the nature and origin of the neoplastic and stromal cells. In contrast to recent reports, donor-derived neoplastic cells were not detected. Bone marrow-derived neoplasia-associated myofibroblasts, however, were identified in the rectal adenoma and in a gastric cancer. Bone marrow-derived cells can generate myofibroblasts in the setting of human gastrointestinal neoplasia.
authors.affiliation: Royal Brisbane and Women's Hospital Foundation Clinical Research Centre, Queensland Institute of Medical Research, Brisbane, Australia. daniel.worthley@uqconnect.edu.au
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Worthley
authors.forename: Andrew
authors.initials: A
authors.lastname: Ruszkiewicz
authors.forename: Ruth
authors.initials: R
authors.lastname: Davies
authors.forename: Sarah
authors.initials: S
authors.lastname: Moore
authors.forename: Ian
authors.initials: I
authors.lastname: Nivison-Smith
authors.forename: L
authors.initials: L
authors.lastname: Bik To
authors.forename: Peter
authors.initials: P
authors.lastname: Browett
authors.forename: Robyn
authors.initials: R
authors.lastname: Western
authors.forename: Simon
authors.initials: S
authors.lastname: Durrant
authors.forename: Jason
authors.initials: J
authors.lastname: So
authors.forename: Graeme P
authors.initials: GP
authors.lastname: Young
authors.forename: Charles G
authors.initials: CG
authors.lastname: Mullighan
authors.forename: Peter G
authors.initials: PG
authors.lastname: Bardy
authors.forename: Michael Z
authors.initials: MZ
authors.lastname: Michael
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects; D005260:Female; D005347:Fibroblasts / Q000473:pathology*; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology; D014184:Transplantation, Homologous