title: Spontaneous regression of vestibular schwannomas after resection of contralateral tumor in neurofibromatosis Type 2.
abstract: The authors report on 2 patients with bilateral vestibular schwannomas (VSs) who underwent unilateral surgical tumor removal. One patient was followed up for 4 years, the other for 9; in both cases, the contralateral VS regressed markedly without any additional treatment during the follow-up period. Serial MR imaging was performed to monitor the untreated tumor, which in both cases involved the only hearing ear. The tumors were assessed volumetrically. The contralateral tumors appeared to enlarge mildly at initial follow-up and then, with no treatment, regressed (to 23% of the original maximum volume in Case 1 and to 15% of the original maximum in Case 2). The largest posterior fossa diameter decreased from 30.1 mm to 18.6 mm in Case 1 over 4 years and from 27 mm to 16 mm over 8 years in Case 2. Hearing declined only mildly during follow-up in both patients. These cases demonstrate the first well-documented, long-term, spontaneous VS regressions in patients with neurofibromatosis Type 2. They underline the importance of careful observation of VS involving the only hearing ear in the management of bilateral VS to determine the natural growth pattern of the tumors. The mechanism of the dramatic spontaneous tumor regression is uncertain.
authors.affiliation: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Kajetan L
authors.initials: KL
authors.lastname: von Eckardstein
authors.forename: Charles W
authors.initials: CW
authors.lastname: Beatty
authors.forename: Colin L W
authors.initials: CL
authors.lastname: Driscoll
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Link
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D015192:Infratentorial Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D016518:Neurofibromatosis 2 / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D009464:Neuroma, Acoustic / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D016896:Treatment Outcome