Chapter 10. Hetero-oligomerization of chemokine receptors.
Although traditionally assumed to be monomeric signaling units, G-protein-coupled receptors (GPCRs) have been shown to exist as dimers/oligomers. Many chemokine receptors have been demonstrated to form homo-oligomers, and hetero-oligomerization between both pairs of chemokine receptors and chemokine receptors and other GPCRs has also been demonstrated. This chapter highlights some of the most common techniques used to investigate chemokine receptor oligomerization.
Appelbe
Shirley
S
Neuroscience and Molecular Pharmacology, University of Glasgow, Glasgow, Scotland, United Kingdom.
Milligan
Graeme
G
D002460:Cell Line; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D047468:Immunoprecipitation; D008163:Luminescent Measurements; D055503:Protein Multimerization; D019707:Receptors, Chemokine / Q000737:chemistry* / Q000378:metabolism*
D019707:Receptors, Chemokine