Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens.
Two new 20,24-bishomo-25-norscalaranes, compounds 1 and 2, and two new and two known 20,24-bishomoscalaranes, compounds 3-6, have been isolated from the Indonesian marine sponge Carteriospongia foliascens. The structures of 1-6 were determined by spectroscopic analysis. Compounds 1 and 3-6 inhibit RCE-protease activity.
Williams
David E
DE
Department of Chemistry, University of British Columbia, Vancouver, BC, Canada.
Hollander
Irwin
I
Feldberg
Larry
L
Frommer
Eileen
E
Mallon
Robert
R
Tahir
Akbar
A
van Soest
Rob
R
Andersen
Raymond J
RJ
D000818:Animals; D010450:Endopeptidases / Q000187:drug effects; D006801:Humans; D007214:Indonesia; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D011480:Protease Inhibitors; D054830:Sesterterpenes; D010450:Endopeptidases; C491326:RCE1 protein, human