Murine polyomavirus tumour specific transplantation antigens and viral persistence in relation to the immune response, and tumour development.
Murine polyomavirus (MPyV) has been instrumental in the studies of transformation in vitro as well as for in vivo studies of virus induced tumour development, and for the studies of immune responses against a tumour virus in its natural host. Moreover, it has been extremely useful for unravelling different aspects of DNA replication, transcription, transformation, cell cycle regulation, and assembly of virus-like particles (VLPs). Here, we review how MPyV has also supplied us with information regarding: the molecular nature of a tumour specific transplantation antigen, knowledge on viral persistence and tumour development in its natural host, as well as experience regarding vaccination against infection with a tumour virus.
Ramqvist
Torbjörn
T
Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, Karolinska University Hospital, Stockholm, Sweden. torbjorn.ramqvist@ki.se
Dalianis
Tina
T
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000276:immunology*; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000821:virology*; D011120:Polyomavirus / Q000276:immunology*; D027601:Polyomavirus Infections / Q000276:immunology* / Q000378:metabolism; D014412:Tumor Virus Infections / Q000276:immunology* / Q000378:metabolism
D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens; C029237:tumor-associated transplantation antigen