Clathrin-mediated endocytosis and Alzheimer's disease: an update.
Thanks to new evidence we are now a step closer to understanding how neurons produce amyloid-beta peptide (Abeta)-the chief culprit of Alzheimer's disease. As importance of clathrin-mediated endocytosis to normal neurons has become clearer, so has its role in pathology of neurological disorders. Here we update recent evidence that endocytosis plays a central role in the production of Abeta in neurons.
Wu
Fangbai
F
Laboratory of Neurosciences, NIA/NIH Biomedical Research Center, Baltimore, MD 21224, United States.
Yao
Pamela J
PJ
D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002966:Clathrin / Q000378:metabolism*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism / Q000648:ultrastructure; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D022161:Transport Vesicles / Q000378:metabolism / Q000648:ultrastructure
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D002966:Clathrin