title: Relationships among bleeding severity, health-related quality of life, and platelet count in children with immune thrombocytopenic purpura.
abstract: Important outcomes for children with immune thrombocytopenic purpura (ITP) include health-related quality of life (HRQOL) and bleeding severity. A HRQOL instrument for children with ITP, the Kids' ITP Tools (KIT), was recently validated. Secondary analysis of the KIT database was performed to determine relationships among platelet count, bleeding severity and HRQOL. Bleeding severity grade correlated with platelet count in chronic ITP but not in acute ITP. Platelet count and bleeding severity failed to have any statistically significant correlations with the KIT scores. These findings suggest that relationships among outcome measures in children with ITP, using currently available instruments, remain poorly defined.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
authors.forename: Cindy E
authors.initials: CE
authors.lastname: Neunert
authors.forename: George R
authors.initials: GR
authors.lastname: Buchanan
authors.forename: Victor
authors.initials: V
authors.lastname: Blanchette
authors.forename: Dorothy
authors.initials: D
authors.lastname: Barnard
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Young
authors.forename: Christine
authors.initials: C
authors.lastname: Curtis
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Klaassen
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000150:complications / Q000523:psychology*; D011788:Quality of Life