Antileishmaniasis activity of flavonoids from Consolida oliveriana.
A set of flavonoids from Consolida oliveriana, kaempferol (1), quercetin (2), trifolin (3), and acetyl hyperoside (5) and their O-acetyl derivatives (1a, 2a, 3a), and octa-O-acetylhyperoside (4) showed leishmanicidal activity against promastigote as well as amastigote forms of Leishmania spp. The cellular proliferation, metabolic, and ultrastructural studies showed that the acetylated compounds 2a, 3a, and 4 were highly active against Leishmania (V.) peruviana, while 2a as well as 4 were effective against Leishmania (V.) braziliensis. These compounds were not cytotoxic and are effective at similar concentrations up to or lower than the reference drugs (pentostam and glucantim).
Marín
Clotilde
C
Department of Parasitology, University of Granada, Granada, Spain.
Boutaleb-Charki
Samira
S
Díaz
Jesús G
JG
Huertas
Oscar
O
Rosales
María J
MJ
Pérez-Cordon
Gregorio
G
Guitierrez-Sánchez
Ramon
R
Sánchez-Moreno
Manuel
M
D000818:Animals; D000967:Antimony Sodium Gluconate / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use*; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use*; D005697:Galactosides / Q000494:pharmacology; D044949:Kaempferols / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy*; D008536:Meglumine / Q000494:pharmacology; D000077485:Meglumine Antimoniate; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000494:pharmacology; D029626:Ranunculaceae / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D014421:Turkey
D000981:Antiprotozoal Agents; D005419:Flavonoids; D005697:Galactosides; D044949:Kaempferols; D009942:Organometallic Compounds; C066407:kaempferol-3-O-galactoside; D008536:Meglumine; C006552:kaempferol; D000077485:Meglumine Antimoniate; D000967:Antimony Sodium Gluconate