title: A twin study of perfume-related respiratory symptoms.
abstract: Respiratory symptoms from environmental perfume exposure are main complaints in patients with multiple chemical sensitivities and often coincide with asthma and or eczema. In this population-based twin study we estimate the heritability of respiratory symptoms related to perfume and if co-occurrences of the symptoms in asthma, atopic dermatitis, hand eczema or contact allergy are influenced by environmental or genetic factors common with these diseases. In total 4,128 twin individuals (82%) responded to a questionnaire. The heritability of respiratory symptoms related to perfume is 0.35, 95%CI 0.14-0.54. Significant associations (p<0.05) between perfume-related respiratory symptoms and asthma, atopic dermatitis, hand eczema or contact allergy are not attributable to shared genetic or shared environmental/familial factors, except possibly for atopic dermatitis where genetic pleiotropy with respiratory symptoms to perfume is suggested by an estimated genetic correlation of 0.39, 95%CI 0.09-0.72.
authors.affiliation: The Danish Research Centre for Chemical Sensitivities, Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Ledreborg Alle 40, 2.th, DK-2820 Gentofte, Denmark. jeel@geh.regionh.dk
authors.forename: J
authors.initials: J
authors.lastname: Elberling
authors.forename: A
authors.initials: A
authors.lastname: Lerbaek
authors.forename: K O
authors.initials: KO
authors.lastname: Kyvik
authors.forename: J
authors.initials: J
authors.lastname: Hjelmborg
mesh_terms: D000328:Adult; D001249:Asthma / Q000235:genetics; D003877:Dermatitis, Contact / Q000235:genetics; D004485:Eczema / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D018777:Multiple Chemical Sensitivity / Q000235:genetics*; D010476:Perfume / Q000633:toxicity*
chemical_list: D010476:Perfume