title: Asymptomatic deep venous thrombosis is associated with a low risk of post-thrombotic syndrome.
abstract: Post-thrombotic syndrome (PTS) is a well-recognized condition that develops after symptomatic deep venous thrombosis, but the clinical significance and late complications of asymptomatic deep venous thrombosis (ADVT) are unclear.
  
  
  OBJECTIVE
  To determine whether ADVT following minor surgery affects venous function and contributes to the later development of PTS.
  
  
  METHODS
  The study included 83 patients operated on for Achilles tendon rupture; 38 patients with postoperative ADVT and 45 patients without (control group). The follow-up examinations five years after the operation comprised computerised strain-gauge plethysmography, colour duplex ultrasonography, clinical scoring of venous disease, and quality of life (QOL).
  
  
  RESULTS
  Villalta scores, CEAP classification and QOL did not differ between groups. PTS (=Villalta score > or =5) was found in three ADVT patients (8%) and in two controls (4%). Ultrasonography revealed post-thrombotic changes in 55% of ADVT patients and in none of the controls. Deep venous reflux occurred in 22 ADVT patients and in three controls (P<0.001). There was no difference between groups in plethysmographic variables, demonstrating that the ultrasonographic abnormalities were of negligible haemodynamic significance.
  
  
  CONCLUSIONS
  PTS is not a common sequel to ADVT after minor surgery. Although more than 50% of patients with ADVT developed post-thrombotic changes according to ultrasound, these changes did not result in haemodynamically significant venous dysfunction.
authors.affiliation: Section of Clinical Physiology, Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, SE-118 83 Stockholm, Sweden. lena.m.persson@sodersjukhuset.se
authors.forename: L M
authors.initials: LM
authors.lastname: Persson
authors.forename: L J
authors.initials: LJ
authors.lastname: Lapidus
authors.forename: G
authors.initials: G
authors.lastname: Lärfars
authors.forename: S
authors.initials: S
authors.lastname: Rosfors
mesh_terms: D000125:Achilles Tendon / Q000293:injuries / Q000601:surgery*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects*; D010991:Plethysmography; D054070:Postthrombotic Syndrome / Q000175:diagnosis / Q000209:etiology*; D011446:Prospective Studies; D011788:Quality of Life; D018570:Risk Assessment; D012421:Rupture; D012720:Severity of Illness Index; D013708:Tendon Injuries / Q000601:surgery*; D018615:Ultrasonography, Doppler, Color; D020246:Venous Thrombosis / Q000150:complications / Q000175:diagnosis / Q000209:etiology*