Adequacy of peritoneal dialysis: beyond small solute clearance.
Peritoneal dialysis adequacy is monitored primarily by indices of small solute clearance, Kt/V(urea) and creatinine clearance (C(cr)). Once a threshold of adequacy has been obtained, however, increasing small solute clearance does not result in improved long-term outcomes of PD patients. There are several other factors that may affect optimal dialysis outcomes. These include, but are not limited to: ultrafiltration, inflammation, malnutrition, and mineral metabolism. In this article, we will briefly review data regarding the relationships between these factors and survival on PD.
Goldberg
Ryan
R
Yalavarthy
Rajesh
R
Teitelbaum
Isaac
I
D003404:Creatinine / Q000652:urine; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy*; D008903:Minerals / Q000378:metabolism; D009752:Nutritional Status / Q000502:physiology; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000592:standards; D011379:Prognosis; D014508:Urea / Q000652:urine
D008903:Minerals; D014508:Urea; D003404:Creatinine