Localised peripheral primitive neuroectodermal tumour (PNET) of the conjunctiva.
A 16-year-old male presented with a 3-month history of an asymptomatic, enlarging conjunctival lesion. An excisional biopsy was performed and histologic and immunohistochemical examination showed characteristic features of a peripheral primitive neuroectodermal tumour (PNET) adjacent to a benign compound naevus. FISH analysis, demonstrating a split-signal at 22q12, confirmed the diagnosis. Staging investigations were negative confirming the primary nature of the lesion. The patient was treated with local wide re-excision and chemotherapy. He remains alive and well 29 months after initial resection.
Moore
Andrew S
AS
Section of Paediatric Oncology, The Institute of Cancer Research & Royal Marsden Hospital, Sutton, Surrey, UK. andrew.moore@icr.ac.uk
Wilson
Peter G
PG
McKelvie
Penny
P
La Nauze
Jamie
J
Hirst
Lawrence W
LW
D000293:Adolescent; D003230:Conjunctival Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*