title: Short-term effects of non-surgical periodontal treatment on plasma level of reactive oxygen metabolites in patients with chronic periodontitis.
abstract: BACKGROUND
  Elevated levels of blood reactive oxygen species (ROS) are associated with the severity of periodontitis. Therefore, improvement of periodontitis may result in a decrease in blood ROS. However, it is unclear how periodontal treatment affects blood ROS. Recently, reactive oxygen metabolites (ROMs) were recognized as a useful measure of blood ROS. The aim of this longitudinal study was to investigate the effect of non-surgical periodontal treatment on plasma ROMs in patients with chronic periodontitis.
  
  
  METHODS
  Nineteen subjects with chronic periodontitis (mean age: 46.8 years) were monitored at baseline (prior to scaling and root planing) and 1 and 2 months after therapy. Dental health parameters were evaluated, and plasma was obtained at these time points from patients and controls (19 subjects without periodontitis; mean age: 45.3 years). The plasma ROM level was determined using a spectrophotometric technique.
  
  
  RESULTS
  At baseline, patients with chronic periodontitis had higher plasma ROM level (441.8 +/- 71.1 Carratelli units) than the control subjects (324.4 +/- 34.0 Carratelli units; P <0.01). Probing depth, clinical attachment level, and bleeding on probing in patients with chronic periodontitis showed a significant improvement 2 months after non-surgical periodontal treatment, and this was accompanied by a significant reduction in plasma ROM level (P <0.01).
  
  
  CONCLUSIONS
  In patients with chronic periodontitis, non-surgical periodontal treatment was effective at improving clinical parameters and reducing plasma ROMs. The improvement in chronic periodontitis by non-surgical periodontal treatment might offer clinical benefits by decreasing blood ROS.
authors.affiliation: Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Tamaki
authors.forename: Takaaki
authors.initials: T
authors.lastname: Tomofuji
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ekuni
authors.forename: Reiko
authors.initials: R
authors.lastname: Yamanaka
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Manabu
authors.initials: M
authors.lastname: Morita
mesh_terms: D000328:Adult; D000368:Aged; D055113:Chronic Periodontitis / Q000097:blood* / Q000628:therapy; D003430:Cross-Sectional Studies; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000295:instrumentation; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000097:blood / Q000628:therapy; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000097:blood / Q000628:therapy; D010514:Periodontal Pocket / Q000097:blood / Q000628:therapy; D017382:Reactive Oxygen Species / Q000097:blood*; D016745:Root Planing / Q000295:instrumentation; D013053:Spectrophotometry; D014464:Ultrasonic Therapy / Q000295:instrumentation; D055815:Young Adult
chemical_list: D017382:Reactive Oxygen Species