Apolipoprotein B levels in adults with type 1 diabetes not receiving lipid-lowering therapy.
OBJECTIVE
To investigate apolipoprotein B (apoB) levels in adult patients with type 1 diabetes with no history of cardiovascular disease and not receiving lipid-lowering therapy.


METHODS
Subjects (n=169) were divided into two groups based on gender. Primary analysis examined lipid parameters and glycosylated hemoglobin. Secondary analysis involved classifying patients according to the Canadian Diabetes Association's (CDA) LDL cholesterol and apoB targets.


RESULTS
Mean apoB levels were 0.81+/-0.17 g/L in males and 0.78+/-0.18 g/L in females. We also found that among patients who failed to achieve the CDA LDL cholesterol target, 62% of males and 66% of females [corrected]met the apoB target.


CONCLUSIONS
There is low prevalence of elevated apoB among patients with type 1 diabetes. In addition, there is discordance between the proportions of patients meeting either LDL cholesterol or apoB targets, thus a significant number of patients may be prescribed lipid-lowering medications unnecessarily.
Mazanderani
Adel B
AB
University of British Columbia, Vancouver, BC, Canada. a.mazanderani@gmail.com
Wise
Stephanie J
SJ
Tildesley
Hugh D
HD
D000328:Adult; D001055:Apolipoproteins B / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents