Early iron supplementation in very low birth weight infants--a randomized  controlled trial.
OBJECTIVE
To evaluate if supplementing iron at 2 weeks of age improves serum ferritin and/or haematological parameters at 2 months of life in very low birth weight (VLBW) infants.


METHODS
Preterm VLBW infants who received at least 100 mL/kg/day of oral feeds by day 14 of life were randomized to either 'early iron' (3-4 mg/kg/day orally from 2 weeks) or 'control' (no iron until 60 days) groups. Infants were followed up fortnightly and all morbidities were prospectively recorded. Serum ferritin was measured at 60 days by enzyme immunoassay method.


RESULTS
Forty-six infants were included in the study; primary outcome was available for 42 infants.There was no difference in either serum ferritin (mean: 50.8 vs. 45.3 microg/L; adjusted difference in means: 5.8, 95% CI: -3.0, 14.6; p = 0.19) or haematocrit (32.5 +/- 5.3 vs. 30.8 +/- 6.3%; p = 0.35)at 60 days between the early iron and control groups. The magnitude of fall in serum ferritin from baseline to the end of study period was also not different between the groups (4.9 vs. 13.8 microg/L; difference in means: 8.8; 95% CI: -0.3, 17.9; p = 0.06). The requirement of blood transfusions (9.5 vs. 13%; p = 0.63) and a composite outcome of common neonatal morbidities (19% vs. 21.7%; p = 0.55) were also not different between the two groups.


CONCLUSIONS
Supplementing iron at 2 weeks of age in preterm VLBW infants did not improve either serum ferritin or the haematological parameters at 2 months when compared to the standard practice of starting iron from 8 weeks of age.
Sankar
Mari Jeeva
MJ
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Saxena
Renu
R
Mani
Kalaivani
K
Agarwal
Ramesh
R
Deorari
Ashok K
AK
Paul
Vinod K
VK
D000367:Age Factors; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000517:prevention & control*; D019587:Dietary Supplements; D005260:Female; D005293:Ferritins / Q000097:blood; D005500:Follow-Up Studies; D006400:Hematocrit; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D019102:Infant, Very Low Birth Weight / Q000097:blood; D007501:Iron / Q000627:therapeutic use*; D008297:Male; D011446:Prospective Studies; D014131:Trace Elements / Q000627:therapeutic use*; D016896:Treatment Outcome
D014131:Trace Elements; D005293:Ferritins; D007501:Iron