Redox dysregulation, neurodevelopment, and schizophrenia.
In schizophrenia, a developmental redox dysregulation constitutes one 'hub' on which converge genetic impairments of glutathione synthesis and environmental vulnerability factors generating oxidative stress. Their timing at critical periods of neurodevelopment could play a decisive role in inducing impairment of neural connectivity and synchronization as observed in schizophrenia. In experimental models, such redox dysregulation induces anomalies strikingly similar to those observed in patients. This is mediated by hypoactive NMDA receptors, impairment of fast-spiking parvalbumin GABA interneurons and deficit in myelination. A treatment restoring the redox balance without side effects yields improvements of negative symptoms in chronic patients. Novel interventions based on these mechanisms if applied in early phases of the disease hold great therapeutic promise.
Do
Kim Q
KQ
Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Site de Cery, CH-1008 Prilly-Lausanne, Switzerland. kim.do@chuv.ch
Cabungcal
Jan H
JH
Frank
Anita
A
Steullet
Pascal
P
Cuenod
Michel
M
D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000503:physiopathology*; D005978:Glutathione / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008959:Models, Neurological; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology*; D012559:Schizophrenia / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*
D005978:Glutathione