title: CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men.
abstract: Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n = 494). The G allele in a SNP located at +30215 on the 3'-untranslated region (UTR) was significantly correlated with the plasma LDL-cholesterol concentrations (r = 0.13, p <0.01). The difference in LDL-cholesterol concentrations was 10 mg dl(-1) between GG- and AA-genotype carriers (p <0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.
authors.affiliation: Department of Internal Medicine, Keio University, School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Morii
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ohno
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirose
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawabe
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hirao
authors.forename: Takashi
authors.initials: T
authors.lastname: Eguchi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Maruyama
authors.forename: Matsuhiko
authors.initials: M
authors.lastname: Hayashi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Saito
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yazaki
authors.forename: Takao
authors.initials: T
authors.lastname: Saruta
mesh_terms: D044466:Asian People / Q000235:genetics; D018955:CD36 Antigens / Q000235:genetics*; D008078:Cholesterol, LDL / Q000097:blood*; D006801:Humans; D007564:Japan; D008297:Male; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D018955:CD36 Antigens; D008078:Cholesterol, LDL