High-fat diet induced adiposity and insulin resistance in mice lacking the myotonic dystrophy protein kinase.
Myotonic dystrophy 1 (MD1) is caused by a CTG expansion in the 3'-unstranslated region of the myotonic dystrophy protein kinase (DMPK) gene. MD1 patients frequently present insulin resistance and increased visceral adiposity. We examined whether DMPK deficiency is a genetic risk factor for high-fat diet-induced adiposity and insulin resistance using the DMPK knockout mouse model. We found that high-fat fed DMPK knockout mice had significantly increased body weights, hypertrophic adipocytes and whole-body insulin resistance compared with wild-type mice. This nutrient-genome interaction should be considered by physicians given the cardiometabolic risks and sedentary lifestyle associated with MD1 patients.
Llagostera
Esther
E
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Carmona
Mari Carmen
MC
Vicente
Meritxell
M
Escorihuela
Rosa María
RM
Kaliman
Perla
P
D017667:Adipocytes / Q000473:pathology; D050154:Adiposity / Q000235:genetics / Q000502:physiology*; D000818:Animals; D049108:Cell Enlargement; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D004195:Disease Models, Animal; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009223:Myotonic Dystrophy / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D012307:Risk Factors; D015430:Weight Gain
C585517:DMPK protein, human; C585516:DMPK protein, mouse; D004041:Dietary Fats; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases