[Association between SNPs in SOD2 and noise-induced hearing loss].
OBJECTIVE
To observe the association between SNPs in SOD2 and noise-induced hearing loss in Chinese Han population.


METHODS
A case-control study was designed to study the effect of environmental risk factors on susceptibility to NIHL in 201 sensitive workers and 202 resistant workers. A questionnaire was designed to carry out an investigation, and an occupational health survey was used to identify the occupational risk factors. Genomic DNA was extracted from peripheral blood cells samples using standard procedures of Qiagen kit. SNPs were detected using standard procedures of TaqMan probe allele identification method.


RESULTS
In SOD2 gene, the C allele of rs4880 was a risk factor of NIHL, compared with the T allele, OR = 1.76, 95% CI 1.17 approximately 2.63, P = 0.006. CC and CT genotypes compared with TT were risk factors, crude OR = 2.24, 95% CI 1.43 approximately 3.50 and adjusted OR = 2.45, 95% CI 1.51 approximately 3.96, P < 0.001, respectively.


CONCLUSIONS
In Chinese Han population, SOD2 rs4880 SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss.
Li
Xu-dong
XD
Guangdong Prevention and Treatment Centre for Occupational Disease, Guangzhou, 510030, China.
Li
Yi-min
YM
Liu
Bin
B
Guo
Xiao
X
Li
Yong-sheng
YS
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006801:Humans; D008297:Male; D009623:Noise, Occupational / Q000009:adverse effects; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000235:genetics*; D055815:Young Adult; D000099156:Superoxide Dismutase 2
D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2