title: Ward reduction of gastroschisis in a single stage without general anaesthesia may increase the risk of short-term morbidities: results of a retrospective audit.
abstract: BACKGROUND
  Ward reduction of gastroschisis in a single stage without the need for general inhalational anaesthesia (ward reduction) has been reported by some authors to be effective and safe. We introduced this practice to our neonatal unit 2 years ago.
  
  
  OBJECTIVE
  To compare the short-term outcomes of this new practice with the standard procedure of reduction under general anaesthesia (GA).
  
  
  METHODS
  Retrospective case series of all infants with gastroschisis between January 2004 and January 2008.
  
  
  RESULTS
  Twenty-seven infants were managed with the traditional approach and 11 infants underwent ward reduction without GA. Infants in the ward reduction group had an increased frequency for all the three major adverse events (ischemic necrosis of bowel: 27.3% vs. 3.7%, odds ratio (OR) 10.72, 95% confidence interval (CI): 0.72, 159.6; need for total parenteral nutrition (TPN) more than 60 days: 18% vs. 3.7%, OR 4.13, 95% CI: 0.28, 61.55; and unplanned return to theatre: 27.3% vs. 7.4%, OR 3.88, 95% CI: 0.44, 34.08), although none of these events reached statistical significance. There were no significant differences between the groups for the outcomes of time to reach full feeds, duration of hospital stay and number of days on antibiotics.
  
  
  CONCLUSIONS
  These results raise concerns over the role of ward reduction of gastroschisis in a single sitting without the use of GA. Randomised trials with appropriate design and sample size are needed before embracing this method as a standard practice.
authors.affiliation: Department of Neonatology, King Edward Memorial Hospital for Women, Western Australia, Australia. Shripada.Rao@health.wa.gov.au
authors.forename: Shripada C
authors.initials: SC
authors.lastname: Rao
authors.forename: Simon
authors.initials: S
authors.lastname: Pirie
authors.forename: Corrado
authors.initials: C
authors.lastname: Minutillo
authors.forename: Ian
authors.initials: I
authors.lastname: Gollow
authors.forename: Jan E
authors.initials: JE
authors.lastname: Dickinson
authors.forename: Peter
authors.initials: P
authors.lastname: Jacoby
mesh_terms: D000768:Anesthesia, General; D001315:Australia; D013505:Digestive System Surgical Procedures / Q000379:methods*; D005260:Female; D020139:Gastroschisis / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008485:Medical Audit; D010362:Patients' Rooms; D011183:Postoperative Complications; D012189:Retrospective Studies; D012306:Risk; D016896:Treatment Outcome