title: DNA microarray technology. Introduction.
abstract: DNA microarray technology has revolutionized biological research by enabling genome-scale explorations. This chapter provides an overview of DNA microarray technology and its application to characterizing the physical genome, with a focus on cancer genomes. Specific areas discussed include investigations of DNA copy number alteration (and loss of heterozygosity), DNA methylation, DNA-protein (i.e., chromatin and transcription factor) interactions, DNA replication, and the integration of diverse genome-scale data types. Also provided is a perspective on recent advances and future directions in characterizing the physical genome.
authors.affiliation: Department of Pathology, Stanford University, Stanford, CA, USA.
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Pollack
mesh_terms: D004247:DNA / Q000235:genetics / Q000378:metabolism; D019175:DNA Methylation; D015894:Genome, Human; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation / Q000379:methods
chemical_list: D004247:DNA