title: [Merkel cell carcinoma: an uncommon neuroendocrine cancer].
abstract: Merkel cell carcinoma (MCC), firstly described by Torker in 1972, is an uncommon and aggressive neuroendocrine cancer of the skin. MCC tends to recur and precociously spread to lymph nodes. Five-year survival rate is between 35 and 75%. In literature there are not univocal criteria regarding the diagnosis and therapy of MCC, probably due to its rarity. Surgery plays an important role in the therapeutic strategy of this cancer. Surgical excision must be wide and guarantee at least 2-3 cm of free tumor margins. Sentinel lymph node biopsy is useful to identify those patients in which extensive lymph node dissection and/or adjuvant therapies (radio- and/or chemotherapy) are advisable. We hereby report a case of MCC of the left arm in a 48 year-old male. A wide excision was performed with sentinel lymph node biopsy that did not show any metastasis. Adjuvant radio therapy was administered. The patient was healthy at one year follow-up.
authors.affiliation: "Sapienza", Università di Roma, Dipartimento di Chirurgia Generale, Specialità Chirurgiche e Trapianti d'Organo "Paride Stefanini", UOC Chirurgia Generale M.
authors.forename: P
authors.initials: P
authors.lastname: Negro
authors.forename: F
authors.initials: F
authors.lastname: Gossetti
authors.forename: C
authors.initials: C
authors.lastname: Brugiotti
authors.forename: M A
authors.initials: MA
authors.lastname: Viarengo
authors.forename: D
authors.initials: D
authors.lastname: Vitolo
authors.forename: L
authors.initials: L
authors.lastname: D'Amore
mesh_terms: D001132:Arm / Q000473:pathology; D015266:Carcinoma, Merkel Cell / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D016896:Treatment Outcome