Preclinical testing on insects predicts human haematotoxic potentials.
The substitution of insects for laboratory animals in toxicity testing is likely to become a reality in the framework of prescreening. Haematotoxicological studies of newly developed chemicals, such as food components, drugs, etc. performed on insects can offer advantages in, for example, environmental toxicology. Reliable routine predictions should produce an increase in our knowledge of haemocyte physiology. Although the differences between human physiology and morphology and those of insects are great, the basic functions of insect haemocytes and mammalian leukocytes appear not to have changed during evolution. The use of insects in haematotoxicity assays represents a preclinical testing strategy which will lower costs, accelerate screening and offer ethical benefits.
Berger
Josef
J
Department of Clinical Studies, Faculty of Health and Social Studies, University of South Bohemia, 37005 Ceské Budejovice, Czech Republic. berger@jcu.cz
D023401:Animal Use Alternatives; D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006402:Hematologic Diseases / Q000139:chemically induced*; D007313:Insecta / Q000187:drug effects*; D011237:Predictive Value of Tests; D013045:Species Specificity; D018675:Toxicity Tests / Q000379:methods*; D015262:Xenobiotics / Q000633:toxicity*
D015262:Xenobiotics