title: Squamous cell carcinoma of the nasal vestibule 1993-2002: a nationwide retrospective study from DAHANCA.
abstract: BACKGROUND
  A retrospective nationwide study of cancer of the nasal vestibule was conducted to evaluate classification systems and prognostic factors for treatment outcome.
  
  
  METHODS
  Patients treated between 1993 and 2002 at head and neck oncology centers in Denmark were included.
  
  
  RESULTS
  The 5-year results were locoregional control 67%, overall survival 50%, cancer-specific survival 74%. Cancer-specific survival according to Wang classification was 83%, 63%, and 39% for T1, T2, T3, respectively (p < .000). Regarding T1 tumors, 5-year locoregional control for surgery, surgery + radiotherapy (RT), or RT was 94%, 87%, or 61%, respectively (p < .000). Fifty-four Gray in 18 fractions was found comparable with 66 Gy in 33 fractions regarding T1 tumors.
  
  
  CONCLUSIONS
  This national survey is the largest series of nasal vestibule cancer ever published. Wang classification is more prognostic and easier to use than the Union Internationale Contre le Cancer 2002. Surgery or hypofractionated RT can be used for T1 lesions, whereas larger lesions should be treated with combined approach.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Aarhus University Hospital, 44 Noerrebrogade, Aarhus, Denmark. a.agger@dadlnet.dk
authors.forename: Andreas
authors.initials: A
authors.lastname: Agger
authors.forename: Christian
authors.initials: C
authors.lastname: von Buchwald
authors.forename: Anders Rørbaek
authors.initials: AR
authors.lastname: Madsen
authors.forename: Jesper
authors.initials: J
authors.lastname: Yde
authors.forename: Iana
authors.initials: I
authors.lastname: Lesnikova
authors.forename: Charlotte Birk
authors.initials: CB
authors.lastname: Christensen
authors.forename: Søren
authors.initials: S
authors.lastname: Foghsgaard
authors.forename: Thomas Broe
authors.initials: TB
authors.lastname: Christensen
authors.forename: Hanne Sand
authors.initials: HS
authors.lastname: Hansen
authors.forename: Susanne
authors.initials: S
authors.lastname: Larsen
authors.forename: Jens
authors.initials: J
authors.lastname: Bentzen
authors.forename: Elo
authors.initials: E
authors.lastname: Andersen
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Andersen
authors.forename: Cai
authors.initials: C
authors.lastname: Grau
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D015331:Cohort Studies; D003131:Combined Modality Therapy; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000145:classification / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D011336:Probability; D018714:Radiotherapy, Adjuvant; D012016:Reference Values; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome