title: Marked iron overload related to ribavirin and iron sulfate treatment in a patient with active viral C cirrhosis.
abstract: Increased ferritin levels are common in the course of chronic hepatitis C, regardless of antiviral therapy. Usually, this increase in ferritin levels has minimal clinical and biological impact, and drops after therapy discontinuation. We report here on a dramatic increase in ferritin levels in a cirrhotic patient with hepatitis C treated by ribavirin monotherapy and oral iron sulphate, and discuss the possible mechanisms of this deleterious effect.
authors.affiliation: Service d'Hépato-Gastroentérologie et de Nutrition, Hôpital Laënnec, Boulevard Laënnec, Creil, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Jouannaud
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cadranel
authors.forename: Patrice
authors.initials: P
authors.lastname: Dumouchel
authors.forename: Alain
authors.initials: A
authors.lastname: Cazier
authors.forename: Dominique
authors.initials: D
authors.lastname: Capron
authors.forename: Jacques
authors.initials: J
authors.lastname: Rochette
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Barbare
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D005293:Ferritins / Q000097:blood; D005296:Ferrous Compounds / Q000009:adverse effects*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D019190:Iron Overload / Q000139:chemically induced*; D008875:Middle Aged; D012254:Ribavirin / Q000009:adverse effects*
chemical_list: D000998:Antiviral Agents; D005296:Ferrous Compounds; C020748:ferrous sulfate; D012254:Ribavirin; D005293:Ferritins