title: Bringing H2AX into the angiogenesis family.
abstract: The cell's ability to sense and respond to DNA damage is critical to maintain homeostasis and prevent the development of cancer. Paradoxically, Economopoulou et al. recently reported that a DNA damage response protein, H2AX, promotes tumor growth and angiogenesis.
authors.affiliation: Department of Radiation Oncology, Division of Radiation and Cancer Biology, Center for Clinical Sciences Research, Stanford University, Stanford, CA 94303-5152, USA.
authors.forename: Erinn B
authors.initials: EB
authors.lastname: Rankin
authors.forename: Amato J
authors.initials: AJ
authors.lastname: Giaccia
authors.forename: Ester M
authors.initials: EM
authors.lastname: Hammond
mesh_terms: D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology; D004249:DNA Damage / Q000502:physiology*; D042783:Endothelial Cells / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D006657:Histones / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism*
chemical_list: C468783:H2AX protein, human; D006657:Histones