title: Effect of subcutaneous lidocaine infiltration on blood loss secondary to corporal lipoaspiration: a prospective, randomized, double-masked clinical trial.
abstract: BACKGROUND
  Lipoaspiration is one of the most frequently performed aesthetic surgical procedures worldwide. The use of tumescent solution containing lidocaine to infiltrate subcutaneous fat before surgery has been accepted as the standard of care for these procedures. Its objective is to diminish postoperative analgesic necessities and secondary blood loss, but its role in hematocrit reduction is not clear at this time. This study aimed to measure the effect of subcutaneous lidocaine infiltration on blood loss secondary to corporal liposuction.
  
  
  METHODS
  A prospective, randomized, double-masked clinical trial was performed. Between November 2005 and July 2007, 70 consecutive female patients submitted to corporal liposuction as a single surgery were included in the study. All the patients were randomly assigned to two groups. The study group received tumescent solution containing lidocaine and epinephrine, whereas the control group received tumescent solution containing only epinephrine. Hematocrit was measured preoperatively, then 2 to 4, 12, and 24 h postoperatively.
  
  
  RESULTS
  The comparison between the two groups did not show significant statistical differences with respect to age, body mass index, infiltrated volume, aspirated fat volume, surgical time, hospital stay, preoperative hematocrit, or comparison of the areas lipoaspirated. The mean hematocrit reduction in the study group was 10.8% +/- 2.9% compared with 8.8% +/- 2.6% in the control group (P = 0.004).
  
  
  CONCLUSIONS
  The use of lidocaine in the tumescent solution for subcutaneous fat infiltration significantly increases postoperative anemia compared with the results obtained when epinephrine infiltration alone is used.
authors.affiliation: Llanos Subercaseaux 2959, Depto 1001, San Miguel, Chile. sllanos3@hotmail.com
authors.forename: Sergio
authors.initials: S
authors.lastname: Llanos
authors.forename: Bruno
authors.initials: B
authors.lastname: Dagnino
authors.forename: Daniel
authors.initials: D
authors.lastname: Ponce
authors.forename: Sebastián
authors.initials: S
authors.lastname: Bonacic
authors.forename: Lindaura
authors.initials: L
authors.lastname: Navarrete
authors.forename: Sandra
authors.initials: S
authors.lastname: Navarrete
authors.forename: Günther
authors.initials: G
authors.lastname: Mangelsdorff
authors.forename: Susana
authors.initials: S
authors.lastname: Searle
authors.forename: Ignacio
authors.initials: I
authors.lastname: Méndez
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000768:Anesthesia, General; D016063:Blood Loss, Surgical / Q000503:physiopathology*; D015992:Body Mass Index; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D004954:Esthetics; D005260:Female; D005500:Follow-Up Studies; D006400:Hematocrit; D006801:Humans; D007279:Injections, Subcutaneous; D007902:Length of Stay; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects*; D015187:Lipectomy / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D010149:Postoperative Pain / Q000503:physiopathology; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D008012:Lidocaine