Asthma and respiratory symptoms in hospital workers related to dampness and biological contaminants.
The National Institute for Occupational Safety and Health investigated respiratory symptoms and asthma in relation to damp indoor environments in employees of two hospitals. A cluster of six work-related asthma cases from one hospital department, whose symptoms arose during a time of significant water incursions, led us to conduct a survey of respiratory health in 1171/1834 employees working in the sentinel cases hospital and a nearby hospital without known indoor environmental concerns. We carried out observational assessment of dampness, air, chair, and floor dust sampling for biological contaminants, and investigation of exposure-response associations for about 500 participants. Many participants with post-hire onset asthma reported diagnosis dates in a period of water incursions and renovations. Post-hire asthma and work-related lower respiratory symptoms were positively associated with the dampness score. Work-related lower respiratory symptoms showed monotonically increasing odds ratios with ergosterol, a marker of fungal biomass. Other fungal and bacterial indices, particle counts, cat allergen and latex allergen were associated with respiratory symptoms. Our data imply new-onset of asthma in relation to water damage, and indicate that work-related respiratory symptoms in hospital workers may be associated with diverse biological contaminants.


CONCLUSIONS
In healthcare facilities with indoor dampness and microbial contamination, possible associations between such conditions and respiratory health effects should be considered. Good building maintenance and housekeeping procedures should lead to improvements in employee respiratory health.
Cox-Ganser
J M
JM
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Jcoxganser@cdc.gov
Rao
C Y
CY
Park
J-H
JH
Schumpert
J C
JC
Kreiss
K
K
D000328:Adult; D016902:Air Pollution, Indoor; D001249:Asthma / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D004391:Dust / Q000032:analysis; D004866:Equipment Contamination; D005260:Female; D005658:Fungi / Q000254:growth & development; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009314:National Institute for Occupational Safety and Health, U.S.; D016273:Occupational Exposure / Q000009:adverse effects; D010564:Personnel, Hospital; D012131:Respiratory Insufficiency / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D014481:United States; D014903:West Virginia / Q000453:epidemiology
D004391:Dust