title: Quantitative 35Cl nuclear quadrupole resonance in tablets of the antidiabetic medicine Diabinese.
abstract: Pulsed (35)Cl nuclear quadrupole resonance (NQR) experiments have been performed on 250-mg tablets of the antidiabetic medicine Diabinese to establish the conditions needed for noninvasive quantitative analysis of the medicine in standard bottles. One important condition is the generation of a uniform radio-frequency (RF) field over the sample, which has been achieved by two designs of sample coil: one of variable pitch, and the other a resonator that has been fabricated from a single turn of copper sheet with a longitudinal gap bridged by tuning capacitors. The results from blind tests show that the number of tablets in a bottle could be predicted to within +/-3%.
authors.affiliation: King's College London, Department of Mechanical Engineering, Strand, London, WC2R 2LS, United Kingdom.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Tate
authors.forename: Kaspar
authors.initials: K
authors.lastname: Althoefer
authors.forename: Jamie
authors.initials: J
authors.lastname: Barras
authors.forename: Michael D
authors.initials: MD
authors.lastname: Rowe
authors.forename: John A S
authors.initials: JA
authors.lastname: Smith
authors.forename: Gareth E S
authors.initials: GE
authors.lastname: Pearce
authors.forename: Stephen A C
authors.initials: SA
authors.lastname: Wren
mesh_terms: D002713:Chlorine / Q000737:chemistry; D002747:Chlorpropamide / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry*; D007553:Isotope Labeling; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011846:Radio Waves; D013607:Tablets
chemical_list: D007004:Hypoglycemic Agents; D013607:Tablets; D002713:Chlorine; D002747:Chlorpropamide