Transcriptional regulation and alternative splicing make for better brains.
In this issue of Neuron, Johnson et al. employ a unique whole-genome exon-level analysis of the developing human brain showing that 76% of genes are expressed along with unexpectedly high levels of differential expression. These results have important consequences for understanding normal and pathological function and provide implications about the uniqueness of being human.
Dehay
Colette
C
Stem Cell and Brain Research Institute, Inserm U846, Bron, France. colette.dehay@inserm.fr
Kennedy
Henry
H
D017398:Alternative Splicing / Q000235:genetics*; D001921:Brain / Q000033:anatomy & histology / Q000196:embryology / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans