Prostatic aspergillosis in a heart transplant recipient: case report and review.
In this study we report the first case of invasive prostatic aspergillosis (IPRA) in a heart recipient with post-transplantation antibody deficiency, and review the other 11 cases described in the medical literature. Seven patients were immunocompromised and 6 had dissemination to other sites. Examination of the prostate usually revealed enlargement, with or without nodular lesions. Transrectal ultrasonography or computed tomography scan can provide the diagnosis, although this should be confirmed with biopsy and culture of the lesion. Urine culture can be negative and treatment should include long-term systemic anti-fungal therapy and, in most cases, prostatectomy.
Valerio
Maricela
M
Department of Clinical Microbiology-Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Fernandez-Cruz
Ana
A
Fernández-Yañez
Juan
J
Palomo
Jesús
J
Guinea
Jesús
J
Durán
Ramón
R
Sarmiento
Elisabeth
E
Carbone
Javier
J
Bouza
Emilio
E
Muñoz
Patricia
P
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy; D001706:Biopsy; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D011467:Prostate / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D011468:Prostatectomy; D011469:Prostatic Diseases / Q000175:diagnosis* / Q000382:microbiology* / Q000628:therapy; D014463:Ultrasonography
D000935:Antifungal Agents