Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity.
Cytokines play a major role in maintaining lymphocyte homeostasis under both steady-state and inflammatory conditions. Unregulated lymphocytes in steady-state conditions can lead to autoimmunity, whereas during inflammation they can cause excessive tissue damage. Regulatory cytokines function in combination with other environmental signals to properly modulate the function and the extent of lymphocyte activation. Many recent studies have highlighted the importance of regulatory cytokines in controlling the differentiation and function of lymphocytes under steady-state and inflammatory conditions, as well as minimizing tissue damage.
Sanjabi
Shomyseh
S
Yale School of Medicine, New Haven, CT 06520, USA.
Zenewicz
Lauren A
LA
Kamanaka
Masahito
M
Flavell
Richard A
RA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D018836:Inflammation Mediators / Q000009:adverse effects / Q000502:physiology*; D016753:Interleukin-10 / Q000009:adverse effects / Q000502:physiology*; D007378:Interleukins / Q000009:adverse effects / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000009:adverse effects / Q000502:physiology*; D000097043:Interleukin-22
D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators; D016753:Interleukin-10; D007378:Interleukins; D016212:Transforming Growth Factor beta; D000097043:Interleukin-22