C-reactive protein predicts non-target lesion revascularization and cardiac events following percutaneous coronary intervention in patients with angina pectoris.
BACKGROUND
C-reactive protein (CRP) plays a pivotal role in the pathogenesis of atherosclerosis progression. We hypothesized that CRP might be related to progression of non-target lesion and prognosis in patients with angina pectoris.


RESULTS
We enrolled 111 patients with angina pectoris treated with coronary stenting. CRP was measured before coronary stenting. Patients were grouped according to the CRP value, high CRP group (n=56, ≥ 0.12 mg/dl) and low CRP group (n=55, <0.12 mg/dl). Kaplan-Meier analysis showed that non-target lesion revascularization (TLR) free survival was significantly lower in the high CRP group than in the low CRP group (log-rank, p=0.004). Moreover, cardiac event (death, myocardial infarction, TLR, and non-TLR) free survival was also significantly lower in the high CRP group than in the low CRP group (p=0.004). By univariate and multivariate analysis, CRP was the only independent predictor of non-TLR (odds ratio, 1.26; p<0.001 [95% confidence interval (CI) 0.98-1.64]). Also, CRP was a predictor of the cardiac events (odds ratio, 1.32; p=0.04 [95% CI 1.02-1.72]).


CONCLUSIONS
CRP was a predictor of non-TLR and cardiac events following stenting in patients with angina pectoris.
Imai
Koichiro
K
Department of Cardiology, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Okura
Hiroyuki
H
Kume
Teruyoshi
T
Yamada
Ryotaro
R
Miyamoto
Yoshinori
Y
Kawamoto
Takahiro
T
Neishi
Yoji
Y
Watanabe
Nozomi
N
Toyota
Eiji
E
Yoshida
Kiyoshi
K
D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis* / Q000502:physiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality*; D009204:Myocardial Revascularization / Q000401:mortality*; D011237:Predictive Value of Tests; D011379:Prognosis; D015607:Stents; D015996:Survival Rate
D015415:Biomarkers; D002097:C-Reactive Protein