title: Changes in sheep oesophageal diameter and function during Geigeria ornativa (vermeerbos) poisoning and subsequent recovery.
abstract: Changes in the oesophageal diameter and function together with changes in body weight, feed intake and the cardiac pulmonary flow index were investigated during experimentally induced poisoning with Geigeria ornativa and subsequent recovery. This was performed under varying conditions for individual sheep. Results showed an increase in the oesophageal diameter index (ODI) during vermeersiekte, accompanied with a decrease in oesophageal function (OF). Cessation of G. ornativa intake resulted in a considerable although incomplete recovery of the ODI. Recovery of the OF for the different sheep, however, varied between 0 and 100%. Detrimental changes in the oesophageal diameter and function were also measured in sheep receiving only subclinical doses of G. ornativa. Decreases in body weight and feed intake commenced 1 to 3 weeks before the onset of vermeersiekte, while indications of a decline in these 2 parameters were also noticed with ingestion of subclinical amounts of G. ornativa. An increase in the cardiac pulmonary flow index (CPFI) to a value indicating the onset of heart failure was found in 1 of the sheep showing clinical signs of vermeersiekte. The CPFI returned to normal after termination of G. ornativa intake.
authors.affiliation: ARC-Onderstepoort Veterinary Institute, Private Bag X5, Onderstepoort, 0110, South Africa. ldsnyman@telkomsa.net
authors.forename: L D
authors.initials: LD
authors.lastname: Snyman
authors.forename: A
authors.initials: A
authors.lastname: Carstens
authors.forename: R A
authors.initials: RA
authors.lastname: Schultz
authors.forename: J P J
authors.initials: JP
authors.lastname: Joubert
authors.forename: L
authors.initials: L
authors.lastname: Labuschagne
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001783:Blood Flow Velocity / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000502:physiology; D004947:Esophagus / Q000033:anatomy & histology* / Q000502:physiology*; D036621:Geigeria / Q000506:poisoning*; D010939:Plant Poisoning / Q000503:physiopathology / Q000662:veterinary*; D011897:Random Allocation; D020127:Recovery of Function; D012756:Sheep; D012757:Sheep Diseases / Q000503:physiopathology*; D013997:Time Factors; D015431:Weight Loss