title: Adaptation and development of software simulation methodologies for cardiovascular engineering: present and future challenges from an end-user perspective.
abstract: This paper describes the use of diverse software tools in cardiovascular applications. These tools were primarily developed in the field of engineering and the applications presented push the boundaries of the software to address events related to venous and arterial valve closure, exploration of dynamic boundary conditions or the inclusion of multi-scale boundary conditions from protein to organ levels. The future of cardiovascular research and the challenges that modellers and clinicians face from validation to clinical uptake are discussed from an end-user perspective.
authors.affiliation: Cardiovascular Engineering and Medical Devices Group, Department of Mechanical Engineering, University College London, Torrington Place, London WC1 7JE, UK. v.diaz@ucl.ac.uk
authors.forename: V
authors.initials: V
authors.lastname: Díaz-Zuccarini
authors.forename: A J
authors.initials: AJ
authors.lastname: Narracott
authors.forename: G
authors.initials: G
authors.lastname: Burriesci
authors.forename: C
authors.initials: C
authors.lastname: Zervides
authors.forename: D
authors.initials: D
authors.lastname: Rafiroiu
authors.forename: D
authors.initials: D
authors.lastname: Jones
authors.forename: D R
authors.initials: DR
authors.lastname: Hose
authors.forename: P V
authors.initials: PV
authors.lastname: Lawford
mesh_terms: D006801:Humans; D012984:Software