[C-reactive protein and risk of ischaemic vascular and cerebrovascular disease--secondary publication].
Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease.
Zacho
Jeppe
J
Herlev Hospital, Klinisk Biokemisk Afdeling.
Tybjaerg-Hansen
Anne
A
Jensen
Jan Skov
JS
Grande
Peer
P
Sillesen
Henrik
H
Nordestgaard
Børge G
BG
D050197:Atherosclerosis / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis* / Q000235:genetics; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000235:genetics; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D017202:Myocardial Ischemia / Q000097:blood* / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors
D015415:Biomarkers; D002097:C-Reactive Protein