Ovarian fibromas with heavy deposition of hyaline globules: a diagnostic pitfall.
We report 5 patients with cellular ovarian fibromas, which contained heavy depositions of hyaline globules, a remarkable and very conspicuous histologic feature of all tumors. The hyaline globules ranged in size from 1 to 25 microm. Some cells were stuffed with myriads of small hyaline globules 1 to 3 microm in size, whereas in the other cells the globules were up to 25 microm in size. The hyaline globules were stained with periodic acid-Schiff, and were mucicarmine and Alcian blue negative. These hyaline globules were present, at least in small numbers, in all 100 hematoxylin and eosin slides reviewed from all 5 cases in this series. Often the cells containing the hyaline globules showed a signet-ring appearance in the more compact cellular areas. All the tumors in our series appear to have a benign course. The patients were without signs of recurrence and without metastasis 1, 2, 3, and 6 years after the excision of the neoplasms. Follow-up in one of the patients was not available. The distinction of the ovarian fibromas with hyaline globules from the Krukenberg tumors and yolk sac tumor is discussed in the paper.
Michal
Michal
M
Sikl's Department of Pathology, Bioptical Laboratory sro, Charles University Hospital, Pilsen, Czech Republic. michal@medima.cz
Kacerovska
Denisa
D
Mukensnabl
Petr
P
Petersson
Fredrik
F
Danis
Dusan
D
Adamkov
Marian
M
Kazakov
Dmitry V
DV
D000293:Adolescent; D003937:Diagnosis, Differential; D018240:Endodermal Sinus Tumor / Q000473:pathology; D005260:Female; D005350:Fibroma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006818:Hyalin / Q000378:metabolism*; D007150:Immunohistochemistry; D007725:Krukenberg Tumor / Q000473:pathology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*