title: Successful treatment of chromoblastomycosis of 36 years duration caused by Fonsecaea monophora.
abstract: We report a case of chromoblastomycosis in a 67-year-old female farmer, which involved a large (20 x 30 cm) cicatricial erythematous plaque on the inner side of her right thigh. The lesion was initially a small nodule which gradually extended over 36 years. Direct microscopic examination revealed a granulomatous lesion with muriform cells surrounded by giant cells. The mould recovered in cultures was dark olivaceous and identified as Fonsecaea monophora by ribosomal internal transcribe spacer (ITS) sequence data. The lesion was successfully cured after 4 months treatment with itraconazole, but there was a relapse.
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Najafzadeh
authors.forename: A
authors.initials: A
authors.lastname: Rezusta
authors.forename: M I
authors.initials: MI
authors.lastname: Cameo
authors.forename: M L
authors.initials: ML
authors.lastname: Zubiri
authors.forename: M C
authors.initials: MC
authors.lastname: Yus
authors.forename: H
authors.initials: H
authors.lastname: Badali
authors.forename: M J
authors.initials: MJ
authors.lastname: Revillo
authors.forename: G S
authors.initials: GS
authors.lastname: De Hoog
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001203:Ascomycota / Q000166:cytology / Q000187:drug effects* / Q000302:isolation & purification; D002862:Chromoblastomycosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D002908:Chronic Disease; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology / Q000627:therapeutic use*; D013848:Thigh / Q000382:microbiology / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole