title: Clinical implications of cortical microvasculature in adult Moyamoya disease.
abstract: We analyzed cortical microvascular parameters using intraoperative ICG (Indocyaninegreen)-Videoangiography in 13 patients with Moyamoya disease, and carried out correlative studies by comparing them with clinical parameters obtained by digital subtraction angiography, physical examination, and regional cerebral blood flow studies. Patients with reduced cerebrovascular reserve capacity were characterized by increased microvascular surface area (MVSA). In addition, MVSA correlated positively with arterial microvascular transit time. Asymptomatic patients were characterized by increased arterial microvascular transit time. We show that patients with a higher arteriogenic potential to alter cortical microvasculature are characterized by a more favorable hemodynamic situation and reduced clinical symptoms.
authors.affiliation: Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, Berlin 13353, Germany. marcus.czabanka@charite.de
authors.forename: Marcus
authors.initials: M
authors.lastname: Czabanka
authors.forename: Pablo
authors.initials: P
authors.lastname: Peña-Tapia
authors.forename: Gerrit Alexander
authors.initials: GA
authors.lastname: Schubert
authors.forename: Johannes
authors.initials: J
authors.lastname: Woitzik
authors.forename: Peter
authors.initials: P
authors.lastname: Horn
authors.forename: Peter
authors.initials: P
authors.lastname: Schmiedek
authors.forename: Peter
authors.initials: P
authors.lastname: Vajkoczy
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D002533:Cerebral Angiography / Q000379:methods; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004396:Coloring Agents; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D055806:Microvessels / Q000503:physiopathology*; D008875:Middle Aged; D009072:Moyamoya Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D014741:Video Recording; D055815:Young Adult
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green