Bilberry inhibits angiogenesis in chick chorioallontoic membrane.
Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. Bilberry has been traditionally used as a folk medicine for some countries. The purpose of the present study was to evaluate the effect of bilberry in chick chorioallantoic membrane angiogenesis model in vivo. In this well characterized model, bilberry inhibited angiogenesis in a concentration-dependent manner. Compared with the normal group, bilberry group has significant decreased vessels proliferation. These results provide evidence that bilberry inhibits angiogenesis and may be useful for treating angiogenesis-dependent human diseases.
Ozgurtas
Taner
T
Department of Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey. chem352000@yahoo.com
Aydin
Ibrahim
I
Tapan
Serkan
S
Avci
Ozgur
O
Erbil
M Kemal
MK
D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology* / Q000627:therapeutic use; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000187:drug effects; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D029800:Vaccinium myrtillus
D020533:Angiogenesis Inhibitors; D000872:Anthocyanins; D010936:Plant Extracts; C073305:Vaccinium myrtillus extract