title: [The use of sinupret in the combined treatment of acute otitis media in children].
abstract: This controlled prospective study included 40 children (18 boys and 22 girls) hospitalized for the treatment of acute suppurative otitis media. Mean age of the patients was 4.5 years. Their condition was evaluated after cessation of purulent discharge and closure of perforation while acoustic impedancometry still revealed the presence of exudate in the tympanum. The treatment included administration of nasal decongestants, systemic antibacterial therapy, sanation of the nasal and pharyngonasal cavities by transposition or puncture of maxillary sinuses. Some patients (study group) were given sinupret in age-adjusted doses. Signs of exudates disappeared within a mean of 4.2 days after the onset of therapy compared with 7.7 days in the control group (p<0.01). It is concluded that the inclusion of sinupret in the combined treatment of acute suppurative otitis media promotes rapid and efficacious sanation of the tympanic cavity and hearing restoration.
authors.forename: M V
authors.initials: MV
authors.lastname: Subbotina
authors.forename: M N
authors.initials: MN
authors.lastname: Kunitsina
authors.forename: I A
authors.initials: IA
authors.lastname: Buksha
authors.forename: M T
authors.initials: MT
authors.lastname: Galchenko
authors.forename: O I
authors.initials: OI
authors.lastname: Platonenko
mesh_terms: D000158:Acoustic Impedance Tests; D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006309:Hearing / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D014663:Nasal Decongestants / Q000008:administration & dosage / Q000627:therapeutic use; D010035:Otitis Media, Suppurative / Q000188:drug therapy* / Q000503:physiopathology; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D014663:Nasal Decongestants; D010936:Plant Extracts; C028353:Sinupret