Clinical factors associated with floppy iris signs: a prospective study from two centers.
To evaluate the relationship of intraoperative floppy iris syndrome with pseudoexfoliation, diabetes mellitus, hypertension, and alpha-1 adrenergic blocker (A1AB) use.



Five hundred patients were included in this prospective study. Intraoperative adverse events, such as pupillary constriction, iris billowing, and iris prolapse from the wound, were noted. Multinomial regression analysis was used to evaluate the relationship of intraoperative floppy iris syndrome with pseudoexfoliation, diabetes mellitus, hypertension, pupil diameter, and A1AB use.



Pupil constriction was significantly associated with pseudoexfoliation (P < .001). Diabetes mellitus was associated with pupil constriction and iris billowing (P = .005 and .003, respectively). Hypertension was associated with pupil constriction (P = .021). Intraoperative floppy iris syndrome was strongly associated with A1AB use and male gender (P < .001 and .039, respectively).



Intraoperative floppy iris syndrome was observed in 2.8% of patients and was strongly related to A1AB use, particularly in smaller pupil diameters. Pseudoexfoliation, diabetes mellitus, and hypertension were not associated with intraoperative floppy iris syndrome.
Altan-Yaycioglu
Rana
R
Department of Ophthalmology, Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center, Ankara, Turkey.
Gedik
Sansal
S
Pelit
Aysel
A
Akova
Yonca A
YA
Akman
Ahmet
A
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D048909:Diabetes Complications; D017889:Exfoliation Syndrome / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D015994:Incidence; D007431:Intraoperative Complications; D007498:Iris / Q000187:drug effects* / Q000473:pathology; D007499:Iris Diseases / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011391:Prolapse; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects; D012307:Risk Factors; D012737:Sex Factors; D013577:Syndrome
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists