Posttranslational modifications of repair factors and histones in the cellular response to stalled replication forks.
DNA damage during replication requires an integration of checkpoint response with replication itself and distinct repair pathways, such as replication pausing, recombination and translesion synthesis. Here we focus on recent advances in our understanding of how protein posttranslational modifications contribute to the maintenance of fork integrity. In particular, we examine the role of histone modifications and chromatin remodeling complexes in this process.
Schleker
Thomas
T
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
Nagai
Shigeki
S
Gasser
Susan M
SM
D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D006657:Histones / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics / Q000378:metabolism*
D006657:Histones