title: Individual cell-based models of cell scatter of ARO and MLP-29 cells in response to hepatocyte growth factor.
abstract: The different behaviors of colonies of two cell lines, ARO (thyroid carcinoma-derived cells) and MLP-29 (mouse liver progenitor cells), in response to hepatocyte growth factor (HGF) are described deducing suitable cellular Potts models (CPM). It is shown how increased motility and decreased adhesiveness are responsible for cell-cell dissociation and tissue invasion in the ARO cells. On the other hand, it is shown that, in addition to the biological mechanisms above, it is necessary to include directional persistence in cell motility and HGF diffusion to describe the scattering and the branching processes characteristic of MLP-29 cells.
authors.affiliation: Department of Mathematics, Politecnico di Torino, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Scianna
authors.forename: Roeland M H
authors.initials: RM
authors.lastname: Merks
authors.forename: Luigi
authors.initials: L
authors.lastname: Preziosi
authors.forename: Enzo
authors.initials: E
authors.lastname: Medico
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008858:Microscopy, Phase-Contrast; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D013234:Stem Cells / Q000187:drug effects; D013964:Thyroid Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured
chemical_list: D017228:Hepatocyte Growth Factor