title: MicroRNA expression profiling in diabetic GK rat model.
abstract: MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleotide microarray to monitor miRNA expression profiles of Goto-Kakizaki (GK) and Wistar rats' skeletal muscle. It was found that seven miRNAs were downexpressed and two miRNAs were over-expressed in the muscle of GK rats. Among them, miR-24 showed the most prominent change. p38 MAPK, which is a direct target of miR-24, also showed expression difference. All the data give a clue that miR-24 might be associated with diabetes through down-regulation of p38 MAPK.
authors.affiliation: State Key Laboratory of Molecular Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Huang
authors.forename: Wenming
authors.initials: W
authors.lastname: Qin
authors.forename: Botao
authors.initials: B
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.forename: Chengguo
authors.initials: C
authors.lastname: Yao
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Huasheng
authors.initials: H
authors.lastname: Xiao
authors.forename: Youxin
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000818:Animals; D001483:Base Sequence; D015153:Blotting, Western; D015342:DNA Probes; D003921:Diabetes Mellitus, Experimental / Q000235:genetics*; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D035683:MicroRNAs / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015342:DNA Probes; D035683:MicroRNAs