title: Three new 7.3',8.5'-connected bicyclo[3.2.1]octanoids and other neolignans from leaves of Nectandra amazonum NEES. (Lauraceae).
abstract: Three new 7.3',8.5'-connected (macrophyllin-type) bicyclo[3.2.1]octanoid neolignans (nectamazins A-C, 1-3) were isolated from leaves of Nectandra amazonum NEES., along with seven known neolignans (4-10). The structures of 1-3 were characterized by spectroscopic methods (1D, 2D NMR) and the absolute configuration was assigned on the basis of circular dichroism (CD) spectra supported by nuclear Overhauser effect spectroscopy (NOESY) correlations. The new compounds showed inhibition activity against platelet activating factor (PAF)-induced aggregation of rabbit platelets.
authors.affiliation: Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Química, Laboratorio de Investigación en Productos Naturales Vegetales, AA 14490, Cra 30 45-03, Ciudad Universitaria, Bogotá D.C., Colombia.
authors.forename: Ericsson David
authors.initials: ED
authors.lastname: Coy Barrera
authors.forename: Luis Enrique
authors.initials: LE
authors.lastname: Cuca Suárez
mesh_terms: D000818:Animals; D002236:Carbohydrate Conformation; D002942:Circular Dichroism; D000431:Ethanol; D020441:Ginkgo biloba / Q000737:chemistry; D066298:In Vitro Techniques; D019770:Lauraceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D017705:Lignans; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D012997:Solvents; C541717:nectamazin A; C541718:nectamazin B; C541716:nectamazin C; D000431:Ethanol