title: One-pot iodination of hydroxypyridines.
abstract: A one-pot, high-yielding iodination of hydroxypyridines and hydroxyquinolines is described. The iodination proceeds under mild conditions, and the products are obtained in high yield without the need for chromatographic purification. In addition, the iodination works on both 2- and 4-hydroxypyridines and -hydroxyquinolines.
authors.affiliation: Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. keVin_maloney@merck.com
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Maloney
authors.forename: Emily
authors.initials: E
authors.lastname: Nwakpuda
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Kuethe
authors.forename: Jingjun
authors.initials: J
authors.lastname: Yin
mesh_terms: D002851:Chromatography, High Pressure Liquid; D054879:Halogenation; D006912:Hydroxyquinolines / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*
chemical_list: D006912:Hydroxyquinolines; D011725:Pyridines; C014047:hydroxypyridines