title: Biomarkers of oxidative stress in babies at high risk for retinopathy of prematurity.
abstract: Oxygen-induced oxidative stress (OS) has damaging effects in the perinatal period. For now there is a lake of evidence that OS occurs in babies with retinopathy of prematurity (ROP) We tests the hypothesis that a strict oxygen policy may minimize postnatal OS reducing severity of ROP. Multicenter prospective cohort study (72 newborns), using a common clinical management protocol with a strict control of oxygen administration. Assessment of biochemical markers of OS in blood samples at birth and on days 7, 14, and 21. Sixteen babies (22.2 per cent) developed ROP stage 1-2. No severe form of ROP was observed. Birth weight and O2 administration in delivery room were the factors significantly associated with the development of ROP stage 1-2. Prematurity and O2 administration in delivery room are the main factors coming into play in the course of ROP. Because room air is richer in oxygen than intrauterine environment, higher OS can be minimized, as well as incidence and severity of ROP, using standardized management with a restricted oxygen breathing policy.
authors.affiliation: Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.
authors.forename: Serafina
authors.initials: S
authors.lastname: Perrone
authors.forename: Piero
authors.initials: P
authors.lastname: Vezzosi
authors.forename: Mariangela
authors.initials: M
authors.lastname: Longini
authors.forename: Barbara
authors.initials: B
authors.lastname: Marzocchi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Paffetti
authors.forename: Carlo V
authors.initials: CV
authors.lastname: Bellieni
authors.forename: Stefano
authors.initials: S
authors.lastname: Martinelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Buonocore
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood*; D001724:Birth Weight; D002851:Chromatography, High Pressure Liquid; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007231:Infant, Newborn; D018384:Oxidative Stress / Q000502:physiology*; D010100:Oxygen / Q000008:administration & dosage* / Q000097:blood; D011446:Prospective Studies; D012178:Retinopathy of Prematurity / Q000175:diagnosis* / Q000378:metabolism*; D012307:Risk Factors; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D010100:Oxygen