title: Vibrational spectroscopy: a clinical tool for cancer diagnostics.
abstract: Vibrational spectroscopy techniques have demonstrated potential to provide non-destructive, rapid, clinically relevant diagnostic information. Early detection is the most important factor in the prevention of cancer. Raman and infrared spectroscopy enable the biochemical signatures from biological tissues to be extracted and analysed. In conjunction with advanced chemometrics such measurements can contribute to the diagnostic assessment of biological material. This paper also illustrates the complementary advantage of using Raman and FTIR spectroscopy technologies together. Clinical requirements are increasingly met by technological developments which show promise to become a clinical reality. This review summarises recent advances in vibrational spectroscopy and their impact on the diagnosis of cancer.
authors.affiliation: Biophotonics Research Unit, Leadon House, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK GL1 3NN.
authors.forename: Catherine
authors.initials: C
authors.lastname: Kendall
authors.forename: Martin
authors.initials: M
authors.lastname: Isabelle
authors.forename: Florian
authors.initials: F
authors.lastname: Bazant-Hegemark
authors.forename: Joanne
authors.initials: J
authors.lastname: Hutchings
authors.forename: Linda
authors.initials: L
authors.lastname: Orr
authors.forename: Jaspreet
authors.initials: J
authors.lastname: Babrah
authors.forename: Rebecca
authors.initials: R
authors.lastname: Baker
authors.forename: Nicholas
authors.initials: N
authors.lastname: Stone
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods*; D013059:Spectrum Analysis, Raman; D014732:Vibration