Symmetry-guided design and fluorous synthesis of a stable and rapidly excreted imaging tracer for (19)F MRI.
Getting FIT: A bispherical (19)F imaging tracer, (19)FIT, was designed and synthesized. (19)FIT is advantageous over perfluorocarbon-based (19)F imaging agents, as it is not retained in the organs and does not require complex formulation procedures. Imaging agents such as (19)FIT can lead to (19)F magnetic resonance imaging (MRI) playing an important role in drug therapy, analogous to the role played by (1)H MRI in disease diagnosis.
Jiang
Zhong-Xing
ZX
Fischell Department of Bioengineering, University of Maryland, College Park, USA.
Liu
Xin
X
Jeong
Eun-Kee
EK
Yu
Yihua Bruce
YB
D000818:Animals; D050091:Dendrimers / Q000737:chemistry; D015195:Drug Design; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D051379:Mice; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*; D051598:Whole Body Imaging
D050091:Dendrimers; D005462:Fluorine Radioisotopes; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals