Malignant amelanotic melanoma developing from an intradermal naevus in a patient with oculocutaneous albinism.
A 43-year-old Taiwanese man who had oculocutaneous albinism type 1 presented with a tumorous lesion over the pubic region. Within the tumour, there was a small pinkish plaque. Histopathologically, the tumour revealed benign naevus cells in the upper dermis and atypical malignant tumour cells in the deeper dermis. Immunohistochemistry using HMB-45 showed intensive positive staining in the deeper dermal tumour cells. Amelanotic malignant melanoma (MM) originating from a pre-existing intradermal naevus was diagnosed.
Wu
C Y
CY
Department of Dermatology, Tri-Service General Hospital, Taipei, Taiwan.
Gao
H W
HW
Chiang
C P
CP
D000328:Adult; D016115:Albinism, Oculocutaneous / Q000473:pathology*; D055088:Early Detection of Cancer; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology*; D018330:Nevus, Intradermal / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*