title: No association between DGKH and bipolar disorder in a Scandinavian case-control sample.
abstract: Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.
authors.affiliation: Institute of Psychiatry, Faculty Division Akershus University Hospital, University of Oslo, Oslo, Norway. m.s.tesli@medisin.uio.no
authors.forename: Martin
authors.initials: M
authors.lastname: Tesli
authors.forename: Anna K
authors.initials: AK
authors.lastname: Kähler
authors.forename: Bettina Kulle
authors.initials: BK
authors.lastname: Andreassen
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
authors.forename: Ole
authors.initials: O
authors.lastname: Mors
authors.forename: Erling
authors.initials: E
authors.lastname: Mellerup
authors.forename: Pernille
authors.initials: P
authors.lastname: Koefoed
authors.forename: Ingrid
authors.initials: I
authors.lastname: Melle
authors.forename: Gunnar
authors.initials: G
authors.lastname: Morken
authors.forename: Katrine V
authors.initials: KV
authors.lastname: Wirgenes
authors.forename: Ole A
authors.initials: OA
authors.lastname: Andreassen
authors.forename: Srdjan
authors.initials: S
authors.lastname: Djurovic
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D019852:Diacylglycerol Kinase / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D012537:Scandinavian and Nordic Countries; D044465:White People / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D019852:Diacylglycerol Kinase