Novel chiral derivatizing isothiocyanate-based agent for the enantiomeric excess determination of amines.
The expedient synthesis of a novel chiral (1S,2S)-N-[(2-isothiocyanato)cyclohexyl] trifluoromethanesulfonamide and its use as a derivatizing auxiliary for the straightforward determination of optical purity of chiral amines are reported.
Sabot
Cyrille
C
Laboratoire des Systèmes Chimiques Fonctionnels, UMR 7199-CNRS, Université de Strasbourg, 74 Route du RhinB.P 60024, 67401 Illkirch Graffenstaden cedex, France.
Mosser
Michel
M
Antheaume
Cyril
C
Mioskowski
Charles
C
Baati
Rachid
R
Wagner
Alain
A
D000588:Amines / Q000737:chemistry*; D017879:Isothiocyanates / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008698:Mesylates / Q000138:chemical synthesis / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
D000588:Amines; D017879:Isothiocyanates; D008698:Mesylates; C542551:N-((2-isothiocyanato)cyclohexyl)trifluoromethanesulfonamide; C037152:isothiocyanic acid