title: Comparison the Carpenter and Coustan thresholds with the new thresholds obtained from Thai pregnant women for the diagnosis of gestational diabetes.
abstract: OBJECTIVE
  To determine the threshold of plasma glucose levels calculated from the mean+2SDs for diagnosing gestational diabetes mellitus (GDM) in Thai women.
  
  
  METHODS
  Thai pregnant women without pre-existing diabetes were invited into the study. A 100-g oral glucose tolerance test (OGTT) was performed in all participants during their second or third trimesters, regardless of the results of 50-g glucose challenge test.
  
  
  RESULTS
  Seven hundred and ninety seven women with singleton pregnancy participated in the study. The distribution of 1-, 2-, and 3-h plasma glucose levels of the 100-g OGTT was Gaussian. The rounded cut-off point values calculated from the mean+2SDs were 90, 195, 170, and 155 mg/dl, respectively for fasting, 1-, 2-, and 3-h plasma glucose. With the Carpenter and Coustan thresholds, 52 women (6.5%, 95%CI 4.9-8.5%) were diagnosed as GDM. Of these, when tested with the new thresholds, 30 had normal glucose tolerance and 22 were diagnosed as GDM.
  
  
  CONCLUSIONS
  By using mean+2SDs of plasma glucose levels of the 100-g OGTT as the threshold for diagnosing GDM, the thresholds at 1, 2, and 3h obtained from Thai women were 15 mg/dl higher than those of the Carpenter and Coustan thresholds.
authors.affiliation: Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand. ssupamai@medicine.psu.ac.th
authors.forename: Supamai
authors.initials: S
authors.lastname: Soonthornpun
authors.forename: Karanrat
authors.initials: K
authors.lastname: Soonthornpun
authors.forename: Jiraporn
authors.initials: J
authors.lastname: Aksonteing
authors.forename: Atchara
authors.initials: A
authors.lastname: Thamprasit
mesh_terms: D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007231:Infant, Newborn; D007328:Insulin / Q000627:therapeutic use; D007567:Jaundice, Neonatal / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D013785:Thailand
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin