Arachidonic acid cytochrome P450 4F2 in hypertension: what can we learn from a transgenic mouse model??
The cytochrome P450-derived 20-hydroxyeicosatetraenoic acid (20-HETE) has known function that plays opposite roles in blood pressure: prohypertensive and antihypertensive. Liu et al. report that the CYP4F2 transgene, driven under an exogenous promoter, increases 20-HETE production and is associated with increased blood pressure in vivo. This study provides evidence for the first time that overexpression of P450 4F2 enzyme results in higher production of 20-HETE, which promotes hypertension. The significance of this transgenic mouse model is further discussed.
Cai
Yiqiang
Y
Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. Electronic address: Yiqiang.cai@yale.edu.
D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism*; D000072470:Cytochrome P450 Family 4; D004195:Disease Models, Animal; D015870:Gene Expression; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D008955:Models, Cardiovascular; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism
D006893:Hydroxyeicosatetraenoic Acids; D011994:Recombinant Proteins; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid; D003577:Cytochrome P-450 Enzyme System; D000072470:Cytochrome P450 Family 4; C117480:CYP4F2 protein, human