Evidence for epistasis between SLC6A4 and a chromosome 4 gene as risk factors in major depression.
Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the SLC6A4 HTTLPR short allele revealed a linkage peak on chromosome 4 (maximum HLOD = 3.5). This evidence suggests epistasis between SLC6A4 and an unknown gene as risk factors for major depression.
Neff
Chris D
CD
Myriad Genetics, Salt Lake City, Utah, USA.
Abkevich
Victor
V
Potter
Jennifer
J
Riley
Robin
R
Shattuck
Donna
D
Katz
David A
DA
D002894:Chromosomes, Human, Pair 4; D003865:Major Depressive Disorder / Q000235:genetics*; D004843:Epistasis, Genetic; D008040:Genetic Linkage; D006801:Humans; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins