title: Federating distributed clinical data for the prediction of adverse hypotensive events.
abstract: The ability to predict adverse hypotensive events, where a patient's arterial blood pressure drops to abnormally low (and dangerous) levels, would be of major benefit to the fields of primary and secondary health care, and especially to the traumatic brain injury domain. A wealth of data exist in health care systems providing information on the major health indicators of patients in hospitals (blood pressure, temperature, heart rate, etc.). It is believed that if enough of these data could be drawn together and analysed in a systematic way, then a system could be built that will trigger an alarm predicting the onset of a hypotensive event over a useful time scale, e.g. half an hour in advance. In such circumstances, avoidance measures can be taken to prevent such events arising. This is the basis for the Avert-IT project (http://www.avert-it.org), a collaborative EU-funded project involving the construction of a hypotension alarm system exploiting Bayesian neural networks using techniques of data federation to bring together the relevant information for study and system development.
authors.affiliation: National e-Science Centre, University of Glasgow, Glasgow G12 8QQ, UK. a.stell@nesc.gla.ac.uk
authors.forename: Anthony
authors.initials: A
authors.lastname: Stell
authors.forename: Richard
authors.initials: R
authors.lastname: Sinnott
authors.forename: Jipu
authors.initials: J
authors.lastname: Jiang
authors.forename: Rob
authors.initials: R
authors.lastname: Donald
authors.forename: Iain
authors.initials: I
authors.lastname: Chambers
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Citerio
authors.forename: Per
authors.initials: P
authors.lastname: Enblad
authors.forename: Barbara
authors.initials: B
authors.lastname: Gregson
authors.forename: Tim
authors.initials: T
authors.lastname: Howells
authors.forename: Karl
authors.initials: K
authors.lastname: Kiening
authors.forename: Pelle
authors.initials: P
authors.lastname: Nilsson
authors.forename: Arminas
authors.initials: A
authors.lastname: Ragauskas
authors.forename: Juan
authors.initials: J
authors.lastname: Sahuquillo
authors.forename: Ian
authors.initials: I
authors.lastname: Piper
mesh_terms: D001499:Bayes Theorem; D001794:Blood Pressure; D001930:Brain Injuries; D006339:Heart Rate; D006801:Humans; D016571:Neural Networks, Computer