title: [Development of biodegradable magnesium-based biomaterials].
abstract: Magnesium is a macroelement which is indispensable to human bodies. As a lightweight metal with high specific strength and favorable biocompatibility, magnesium and its alloys have been introduced in the field of biomedical materials research and have a broad application prospect. It is possible to develop new type of biodegradable medical magnesium alloys by use of the poor corrosion resistance of magnesium. Bioabsorbable magnesium stents implanted in vivo could mechanically support the vessel in a short term, effectly prevent the acute coronary occlusion and in-stent restenosis, and then be gradully biodegraded and completely absorbed in a long term. Osteoconductive bioactivity in magnesium-based alloys could promote the apposition growth of bone tissue. This paper reviews the progress of magnesium and its alloys applied in bone tissue and cardiovascular stents, and the prospect of the future research of magnesium-based biomaterials is discussed.
authors.affiliation: Key Lab. of Advanced Technology of Materials (Chinese Education Ministry), Southwest Jiaotong University, Chengdu 610031, China.
authors.forename: Shengfa
authors.initials: S
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Nan
authors.initials: N
authors.lastname: Huang
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000737:chemistry* / Q000378:metabolism; D015607:Stents
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D018786:Bone Substitutes; D008274:Magnesium