Effect of radiofrequency electromagnetic field exposure on in vitro models of neurodegenerative disease.
In this work we tested viability, proliferation, and vulnerability of neural cells, after continuous radiofrequency (RF) electromagnetic fields exposure (global system for mobile telecommunications (GSM) modulated 900 MHz signal at a specific absorption rate (SAR) of 1 W/kg and maximum duration 144 h) generated by transverse electromagnetic cells. We used two cellular systems, SN56 cholinergic for example, SN56 cholinergic cell line and rat primary cortical neurons, and well-known neurotoxic challenges, such as glutamate, 25-35AA beta-amyloid, and hydrogen peroxide. Exposure to RF did not change viability/proliferation rate of the SN56 cholinergic cells or viability of cortical neurons. Co-exposure to RF exacerbated neurotoxic effect of hydrogen peroxide in SN56, but not in primary cortical neurons, whereas no cooperative effects of RF with glutamate and 25-35AA beta-amyloid were found. These data suggest that only under particular circumstances exposure to GSM modulated, 900 MHz signal act as a co-stressor for oxidative damage of neural cells.
Del Vecchio
Giovanna
G
Department of Veterinary Morphophysiology and Animal Production, Bologna University, Bologna, Italy.
Giuliani
Alessandro
A
Fernandez
Mercedes
M
Mesirca
Pietro
P
Bersani
Ferdinando
F
Pinto
Rosanna
R
Ardoino
Lucia
L
Lovisolo
Giorgio A
GA
Giardino
Luciana
L
Calzà
Laura
L
D000818:Animals; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004781:Environmental Exposure; D018698:Glutamic Acid / Q000378:metabolism*; D008872:Microwaves; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D009474:Neurons / Q000528:radiation effects*; D051381:Rats
D018698:Glutamic Acid