Effect of white wheat bread containing sugar beet fiber on serum lipids and hepatic mRNA in rats fed on a cholesterol-free diet.
We examined the effects of white wheat bread powder (BP) and white wheat bread powder containing sugar beet fiber (BBP) on serum cholesterol. The total cholesterol (-11%, -16%), HDL-cholesterol (-12%, -11%), non-HDL-cholesterol (-9%, -18%) and triacylglycerol (-44%, -58%) concentrations in the BP and BBP groups, respectively, were significantly different from those in the control group. The fecal excretion of neutral sterols in the BP and BBP groups and of acidic sterols in the BBP group was significantly higher than that in the control group. The hepatic cholesterol 7alpha-hydroxylase (CYP7A1) mRNA level in the BP and BBP groups was significantly higher than that in the control group. The cecal total short-chain fatty acid concentrations in the BBP group were significantly higher than those in the control group. These results indicate that the observed changes in serum lipid levels in the BP and BBP groups were due to the increased fecal lipid and CYP7A1 mRNA levels.
Nakamura
Yumi
Y
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Kanazawa
Mizuki
M
Liyanage
Ruvini
R
Iijima
Setsuko
S
Han
Kyu-Ho
KH
Shimada
Ken-ichiro
K
Sekikawa
Mitsuo
M
Yamauchi
Akihiro
A
Hashimoto
Naoto
N
Ohba
Kiyoshi
K
Fukushima
Michihiro
M
D000818:Animals; D001483:Base Sequence; D027461:Beta vulgaris / Q000737:chemistry*; D001939:Bread; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D017931:DNA Primers; D004043:Dietary Fiber / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D020133:Reverse Transcriptase Polymerase Chain Reaction
D002791:Cholesterol, Dietary; D017931:DNA Primers; D004043:Dietary Fiber; D008055:Lipids; D012333:RNA, Messenger; C532838:CYP7A1 protein, rat; D002790:Cholesterol 7-alpha-Hydroxylase