title: Three novel sesquiterpene esters from Celastrus angulatus.
abstract: Three new sesquiterpene polyol esters with a beta-dihydroagarofuran skeleton, NW12 (1), NW27 (2), and NW31 (4), together with a known compound, NW30 (3), were isolated from the root bark of Celastrus angulatus. Their chemical structures were elucidated by analyses of MS and NMR spectral data. Preliminary insecticidal and antitumor activities of these compounds were evaluated. Compounds 1-4 showed moderate stomach toxicity against Mythimna separata, and their KD50 values were 673.6, 1121.3, 1720.0 and 548.6 microg/g, respectively. Only 1 and 3 exhibited slight antitumor activity against human breast cancer cell line (Bcap-37), and their IC50 values were all above 50 microM.
authors.affiliation: Institute of Pesticide Science, Northwest Agricultural & Forestry University, Shaanxi 712100, China.
authors.forename: Shaopeng
authors.initials: S
authors.lastname: Wei
authors.forename: Mingan
authors.initials: M
authors.lastname: Wang
authors.forename: Jiwen
authors.initials: J
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Qian
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Ji
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031247:Celastrus / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007306:Insecticides; D013058:Mass Spectrometry; D009036:Moths; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007306:Insecticides; D012717:Sesquiterpenes