title: Two year sublingual immunotherapy affects serum leptin.
abstract: BACKGROUND
  It has been demonstrated that serum leptin is elevated in females with allergic rhinitis. Recently, it has been reported that one course of sublingual immunotherapy (SLIT) does not affect serum leptin levels.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the serum leptin levels in a cohort of patients with pollen-induced allergic rhinitis, before and after two pre-seasonal SLIT courses.
  
  
  METHODS
  Forty-one patients (22 males and 19 females, median age 39 years) with AR, due to pollen allergy, and 34 healthy subjects (16 males and 18 females, median age 43 years) were included in the study. Blood sampling for assessing serum leptin was performed in all subjects before and after the second SLIT course.
  
  
  RESULTS
  All patients were responders to SLIT. Serum leptin was significantly increased only in males (p=0.0056) after the second SLIT course.
  
  
  CONCLUSIONS
  This preliminary study shows that at least two pre-seasonal SLIT courses were required to induce significant modifications in serum leptin levels, but it occurred only in males. Some hypotheses might be outlined, including a leptin protective effect, however further studies must clarify this issue.
authors.affiliation: Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino-University of Genoa, Genoa, Italy. giocip@unige.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ciprandi
authors.forename: Mara
authors.initials: M
authors.lastname: De Amici
authors.forename: Mariangela
authors.initials: M
authors.lastname: Tosca
authors.forename: Simone
authors.initials: S
authors.lastname: Negrini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Murdaca
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Marseglia
mesh_terms: D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology*; D029662:Betula / Q000276:immunology; D015331:Cohort Studies; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D020738:Leptin / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy*; D012737:Sex Factors; D012882:Skin Tests; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D020738:Leptin