No association between DGKH and bipolar disorder in a Scandinavian case-control sample.
Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.
Tesli
Martin
M
Institute of Psychiatry, Faculty Division Akershus University Hospital, University of Oslo, Oslo, Norway. m.s.tesli@medisin.uio.no
Kähler
Anna K
AK
Andreassen
Bettina Kulle
BK
Werge
Thomas
T
Mors
Ole
O
Mellerup
Erling
E
Koefoed
Pernille
P
Melle
Ingrid
I
Morken
Gunnar
G
Wirgenes
Katrine V
KV
Andreassen
Ole A
OA
Djurovic
Srdjan
S
D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D019852:Diacylglycerol Kinase / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D012537:Scandinavian and Nordic Countries; D044465:White People / Q000235:genetics*
D005819:Genetic Markers; D019852:Diacylglycerol Kinase