title: The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population.
abstract: CTLA4 genetic polymorphisms have been associated with type 1 diabetes. We genotyped 207 patients and 249 controls for the most frequently investigated polymorphism of the CTLA4 gene (+49A/G (rs231775)). No significant differences were observed, suggesting that this polymorphism is not strongly associated with type 1 diabetes in the Portuguese population.
authors.affiliation: Health Sciences Research Centre (CICS), Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal. mclemos@fcsaude.ubi.pt
authors.forename: M C
authors.initials: MC
authors.lastname: Lemos
authors.forename: E
authors.initials: E
authors.lastname: Coutinho
authors.forename: L
authors.initials: L
authors.lastname: Gomes
authors.forename: M
authors.initials: M
authors.lastname: Bastos
authors.forename: A
authors.initials: A
authors.lastname: Fagulha
authors.forename: L
authors.initials: L
authors.lastname: Barros
authors.forename: F
authors.initials: F
authors.lastname: Carrilho
authors.forename: E
authors.initials: E
authors.lastname: Geraldes
authors.forename: F J
authors.initials: FJ
authors.lastname: Regateiro
authors.forename: M
authors.initials: M
authors.lastname: Carvalheiro
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011174:Portugal / Q000453:epidemiology; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human