A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with risk of coal workers' pneumoconiosis.
Coal workers' pneumoconiosis (CWP) is a chronic interstitial lung disease with a complex etiology that can occur after cumulative dust exposure. A case-control study was conducted to test the hypothesis that single-nucleotide polymorphisms (SNP) within CASPASE-8 (CASP8) promoter involved in resolution of inflammatory processes modulate the risk of CWP development. The study population consisted of 619 underground coal miners in the 5 coal mines of Xuzhou Mining Business Group Co. Ltd., China, of whom 315 were diagnosed with CWP. The association study between CASP8 -652 6N ins/del polymorphism with CWP by multiple logistic regression analysis showed a significant association of the genotype del/del with CWP compared with to ins/ins genotypes, and showed that the risk was significantly higher for stage I CWP. Further analysis showed that in subjects with the del/del genotype there was significantly increased risk for CWP occurrence among younger individuals (<66 yr) or those with longer duration dust exposure (>or=26 yr). These findings suggested that CASP8-652 6N ins/del polymorphism may contribute to the genetic susceptibility for CWP development.
Ni
Chunhui
C
Departments of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Ye
Yang
Y
Wang
Meilin
M
Qian
Haiyang
H
Song
Zhifang
Z
Jia
Xiaomin
X
Zhou
Jianwei
J
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D055008:Anthracosis / Q000235:genetics*; D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D016254:Mutagenesis, Insertional / Q000235:genetics; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D017384:Sequence Deletion / Q000235:genetics; D013997:Time Factors
D053181:Caspase 8