Stem cells and solid cancers.
Recently, there have been significant advances in our knowledge of stem cells found in tissues that can develop solid tumours. In particular, novel stem cell markers have been identified for the first time identifying multipotential cells: a required characteristic of a stem cell. The scarcity of cancer stem cells has been questioned. Current dogma states that they are rare, but novel research has suggested that this may not be the case. Here, we review the latest literature on stem cells, particularly cancer stem cells within solid tumours. We discuss current thinking on how stem cells develop into cancer stem cells and how they protect themselves from doing so and do they express unique markers that can be used to detect stem cells. We attempt to put into perspective these latest advances in stem cell biology and their potential for cancer therapy.
McDonald
Stuart A C
SA
Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Blizard Building, 4 Newark Street, Whitechapel, London, E1 2AT, UK. stuart.mcdonald@cancer.org.uk
Graham
Trevor A
TA
Schier
Stefanie
S
Wright
Nicholas A
NA
Alison
Malcolm R
MR
D000071916:AC133 Antigen; D053687:Adult Stem Cells / Q000502:physiology; D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D015415:Biomarkers; D002455:Cell Division; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology / Q000502:physiology*; D010455:Peptides / Q000032:analysis; D013234:Stem Cells / Q000502:physiology*
D000071916:AC133 Antigen; D015703:Antigens, CD; D015415:Biomarkers; D006023:Glycoproteins; D010455:Peptides