title: Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys.
abstract: OBJECTIVE
  We investigate the effects of a 2-month weight-loss programme on plasma levels of adiponectin, leptin and resistin in obese adolescent boys.
  
  
  METHODS
  Twenty-one obese adolescent boys (BMI = 30.8 +/- 3.2 kg/m(2)) completed the weight-loss programme including: 1/ either energy restriction (R), 2/ or individualized exercise training at the point of maximum lipid oxidation (Lipox(max)) (E), 3/ or energy restriction and training (RE). Body composition, lipid oxidation and plasma levels of adiponectin, leptin and resistin were measured before and after intervention.
  
  
  RESULTS
  Following the weight-loss programme, adolescents of the RE group showed an improvement of their body composition (p < 0.01), an increase in plasma adiponectin (+73.7%, p < 0.01) and a decrease in plasma leptin (-38.8%, p < 0.01) leading to an increase in adiponectine/leptin ratio (ALR, +144.4%, p < 0.01) higher than the R or E groups. E and RE groups only showed a similar significant increase in plasma resistin (p < 0.05) and a significant improvement of lipid oxidation rate at Lipox(max) (p < 0.01 and p < 0.001). In addition, in RE group, ALR is correlated with waist/hip and waist/height ratios, resistin level, homoeostasis mode assessment (HOMA-IR) index and Lipox(max).
  
  
  CONCLUSIONS
  In obese adolescents boys, moderate exercise training completed at Lipox(max) and combined with energy restriction improves their ability to oxidize lipids, which is associated with a normalization of their adiponectin, leptin and resistin levels resulting in an improved insulin sensitivity, as attested by a higher ALR and a lower HOMA-IR.
authors.affiliation: Laboratory of Exercise Biology (BAPS), Blaise Pascal University, Bat Biologie B, Aubière, France. elloumimed@yahoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Elloumi
authors.forename: O
authors.initials: O
authors.lastname: Ben Ounis
authors.forename: E
authors.initials: E
authors.lastname: Makni
authors.forename: E
authors.initials: E
authors.lastname: Van Praagh
authors.forename: Z
authors.initials: Z
authors.lastname: Tabka
authors.forename: G
authors.initials: G
authors.lastname: Lac
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D001823:Body Composition; D031204:Caloric Restriction; D003131:Combined Modality Therapy; D004038:Diet, Reducing; D015444:Exercise / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000737:chemistry; D008297:Male; D009765:Obesity / Q000097:blood* / Q000628:therapy; D010084:Oxidation-Reduction; D012044:Regression Analysis; D052243:Resistin / Q000097:blood*; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*
chemical_list: D052242:Adiponectin; D020738:Leptin; D008055:Lipids; D052243:Resistin