title: Separation of absorption and scattering profiles in spectroscopic optical coherence tomography using a least-squares algorithm.
abstract: In spectroscopic optical coherence tomography, it is important and useful to separately estimate the absorption and the scattering properties of tissue. In this paper, we propose a least-squares fitting algorithm to separate absorption and scattering profiles when near-infrared absorbing dyes are used. The algorithm utilizes the broadband Ti:sapphire laser spectrum together with joint time-frequency analysis. Noise contribution to the final estimation was analyzed using simulation. The validity of our algorithm was demonstrated using both single-layer and multi-layer tissue phantoms.
authors.forename: Chenyang
authors.initials: C
authors.lastname: Xu
authors.forename: Daniel
authors.initials: D
authors.lastname: Marks
authors.forename: Minh
authors.initials: M
authors.lastname: Do
authors.forename: Stephen
authors.initials: S
authors.lastname: Boppart