The role of GSK3 in Alzheimer disease.
Mutations in app, ps-1 and ps-2 genes result in the appearance of Familial Alzheimer disease (FAD). Although, in many cases, those mutations result in an increase of the amount of beta amyloid peptide, there is not a clear correlation between that amount and the time of the onset of the disease. Thus, other factors may explain how mutations in those genes result in the appearance of neurodegeneration. In this minireview we propose that GSK3 could be one of those factors.
Hernández
Félix
F
Centro de Bioligía Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Campus Cantoblanco, 28049 Madrid, Spain. fhernadez@cbm.uam.es
de Barreda
Elena Gómez
EG
Fuster-Matanzo
Almudena
A
Goñi-Oliver
Paloma
P
Lucas
José J
JJ
Avila
Jesús
J
D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*; D006801:Humans; D051379:Mice; D010766:Phosphorylation; D016875:tau Proteins / Q000378:metabolism
D016875:tau Proteins; D038362:Glycogen Synthase Kinase 3