Identification of a bioactive compound isolated from Brazilian propolis type 6.
A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
Castro
Myrella Lessio
ML
Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), C.P. 52, 13414-903, Piracicaba, SP, Brazil.
do Nascimento
Andréa Mendes
AM
Ikegaki
Masaharu
M
Costa-Neto
Cláudio M
CM
Alencar
Severino M
SM
Rosalen
Pedro L
PL
D000190:Actinomyces / Q000187:drug effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D001422:Bacterial Adhesion / Q000187:drug effects; D001516:Bees / Q000378:metabolism; D001577:Benzophenones / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D001938:Brazil; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D009154:Mutation; D054876:Prenylation; D011429:Propolis / Q000737:chemistry*; D013210:Staphylococcus / Q000187:drug effects / Q000235:genetics
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001577:Benzophenones; D011429:Propolis