Methimazole-induced antineutrophil cytoplasmic antibody-associated diffuse alveolar haemorrhage in a Chinese woman with Graves' disease.
We report on a case of diffuse alveolar haemorrhage in a Chinese woman due to methimazole-induced antineutrophil cytoplasmic antibodies. A literature search for anti-thyroid drugs associated with antineutrophil cytoplasmic antibody-induced diffuse alveolar haemorrhages is reviewed. Diffuse alveolar haemorrhage is a rare complication of thiourea agents and the treatment often requires corticosteroids or other immunosuppressants, together with withdrawal of the causative agent.
Lau
Emmy Y F
EY
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong.
So
S Y
SY
Chan
Eric
E
Kwok
Janette
J
Ma
John
J
Kung
Annie W C
AW
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015897:Comorbidity; D005260:Female; D006111:Graves Disease / Q000188:drug therapy* / Q000453:epidemiology; D006470:Hemorrhage / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology / Q000276:immunology*; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use; D011650:Pulmonary Alveoli; D014657:Vasculitis / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D008713:Methimazole