Red mold dioscorea has a greater antihypertensive effect than traditional red mold rice in spontaneously hypertensive rats.
The aim of this study is to investigate the antihypertensive effects of red mold rice (RMR) and red mold dioscorea (RMD) by low-dose oral administration to spontaneously hypertensive rats (SHRs). A single oral dose of 1-fold RMD (150 mg/kg) significantly (p < 0.05) decreased systolic blood pressure (SBP) and diastolic blood pressure (DBP) after 8 h of administration, but RMR showed no significant effect. During the chronic oral administration of 1-fold RMR (150 mg/kg), 0.5-fold RMD, 1-fold RMD, and 5-fold RMD to SHRs for 8 weeks, the increase of blood pressure was slowed significantly. The results indicated that only a 0.5-fold dose of RMD was able to significantly decrease both SBP and DBP. A 1-fold RMD showed a greater antihypertensive effect than 1-fold RMR, and both RMR and RMD can improve the vascular elastin structure remodeling. In comparison to RMR, RMD contained a higher amount of gamma-aminobutyric acid (GABA) and anti-inflammatory yellow pigments (monascin and ankaflavin). Moreover, RMD also exhibited higher angiotensin-I-converting enzyme (ACE) inhibitory activity than RMR. These results suggest that RMD has greater antihypertensive bioavailability.
Wu
Cheng-Lun
CL
Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan, Republic of China.
Lee
Chun-Lin
CL
Pan
Tzu-Ming
TM
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D027742:Dioscorea / Q000737:chemistry / Q000382:microbiology*; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D032741:Monascus / Q000378:metabolism*; D012275:Oryza / Q000737:chemistry / Q000382:microbiology*; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D010936:Plant Extracts