title: [Human papillomavirus and cervical neoplasia].
abstract: Human papillomavirus (HPV) has been established as an important etiological factor for the development of cervical cancer. This DNA virus primarily infects the epithelium and can induce benign and malignant lesions of the mucous membranes and skin. Some HPVs are considered high risk due to their role in malignant progression of cervical tumors. Genital HPV infections are common and usually transient among young sexually active women. Only a small fraction of infected women develop cervical cancer, implying the involvement of environmental and genetic cofactors in cervical carcinogenesis. Classification, virology, pathology, natural history, epidemiological features of genital HPV infection, and future prospects for cervical cancer prevention with HPV vaccines will be reviewed here.
authors.affiliation: Curso de Medicina, Universidade do Extremo Sul Catarinense, Criciúma, Brasil. mir@unesc.net
authors.forename: Maria Inês da
authors.initials: MI
authors.lastname: Rosa
authors.forename: Lídia Rosi
authors.initials: LR
authors.lastname: Medeiros
authors.forename: Daniela Dornelles
authors.initials: DD
authors.lastname: Rosa
authors.forename: Mary Clarisse
authors.initials: MC
authors.lastname: Bozzeti
authors.forename: Fábio Rosa
authors.initials: FR
authors.lastname: Silva
authors.forename: Bruno Rosa
authors.initials: BR
authors.lastname: Silva
mesh_terms: D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000145:classification*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D053918:Papillomavirus Vaccines; D015995:Prevalence; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000821:virology*
chemical_list: D053918:Papillomavirus Vaccines