Genetic variation in the vitamin D receptor and polycystic ovary syndrome risk.
The possible association of vitamin D receptor gene FokI, BsmI, ApaI, and TaqI polymorphisms with polycystic ovary syndrome (PCOS) risk, and their influence on insulin resistance and serum levels of insulin in the women with PCOS was examined. The findings of the present study indicate that genetic variation in the vitamin D receptor may affect PCOS development as well as insulin resistance in women with PCOS.
Mahmoudi
Touraj
T
Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran. Electronic address: mahmouditouraj@gmail.com.
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000502:physiology; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D015810:Linkage Disequilibrium; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D055815:Young Adult
D010281:Parathyroid Hormone; D018167:Receptors, Calcitriol; D014807:Vitamin D; C104450:25-hydroxyvitamin D