Recurrence of granulomatous interstitial nephritis in transplanted kidney.
Sarcoidosis is a multisystemic disease of unknown etiology. Minor renal involvement is not rare but kidney failure is uncommon and only rare cases of recurrent disease in a kidney transplant have been published. We report a patient who at age 10 yr developed ESRD secondary to renal sarcoidosis with GIN. Her disease subsequently recurred in the transplanted kidney despite standard immunosuppression with prednisone, tacrolimus, and mycophenolate mofetil. The recurrent disease appeared to respond to increased immunosuppression, which included infliximab. However, the patient died of disseminated histoplasmosis three yr post-transplant.
Vargas
Federico
F
Departments of Pediatrics and Pathology, Children's Hospital and Louisiana Health Sciences Center, New Orleans, LA 70118,USA.
Gedalia
Abraham
A
Craver
Randall D
RD
Matti Vehaskari
V
V
D000293:Adolescent; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic; D016030:Kidney Transplantation; D009395:Nephritis, Interstitial / Q000188:drug therapy / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D012008:Recurrence; D012507:Sarcoidosis / Q000150:complications*
D007166:Immunosuppressive Agents