title: Advanced scanning methods with tracking optical coherence tomography.
abstract: An upgraded optical coherence tomography system with integrated retinal tracker (TOCT) was developed. The upgraded system uses improved components to extend the tracking bandwidth, fully integrates the tracking hardware into the optical head of the clinical OCT system, and operates from a single software platform. The system was able to achieve transverse scan registration with sub-pixel accuracy (~10 microm). We demonstrate several advanced scan sequences with the TOCT, including composite scans averaged (co-added) from multiple B-scans taken consecutively and several hours apart, en face images collected by summing the A-scans of circular, line, and raster scans, and three-dimensional (3D) retinal maps of the fovea and optic disc. The new system achieves highly accurate OCT scan registration yielding composite images with significantly improved spatial resolution, increased signal-to-noise ratio, and reduced speckle while maintaining well-defined boundaries and sharp fine structure compared to single scans. Precise re-registration of multiple scans over separate imaging sessions demonstrates TOCT utility for longitudinal studies. En face images and 3D data cubes generated from these data reveal high fidelity image registration with tracking, despite scan durations of more than one minute.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hammer
authors.forename: R Daniel
authors.initials: RD
authors.lastname: Ferguson
authors.forename: Nicusor
authors.initials: N
authors.lastname: Iftimia
authors.forename: Teoman
authors.initials: T
authors.lastname: Ustun
authors.forename: Gadi
authors.initials: G
authors.lastname: Wollstein
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Michelle
authors.initials: M
authors.lastname: Gabriele
authors.forename: William
authors.initials: W
authors.lastname: Dilworth
authors.forename: Larry
authors.initials: L
authors.lastname: Kagemann
authors.forename: Joel
authors.initials: J
authors.lastname: Schuman