Intravascular lymphomatosis of the brain in a patient with myelodysplastic syndrome.
BACKGROUND
A 77-year-old retired research pharmacologist with a long-standing history of anemia and a recent pathologically confirmed diagnosis of myelodysplastic syndrome was referred to a stroke unit for evaluation of slowly progressive cognitive deterioration, confusion and paroxysmal stroke-like episodes. A previous neurological work-up had revealed no noteworthy abnormalities except for chronic bilateral caudate infarctions seen on MRI and CT examinations of the brain.


METHODS
Physical examination, laboratory testing, brain MRI scanning, EEG, transesophageal echocardiography, cerebral angiography, CT scanning, and brain biopsy.


METHODS
Intravascular lymphomatosis of the brain.


RESULTS
Combined chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) and rituximab.
Sips
Gregorius J
GJ
University Medical Center Groningen, Groningen, The Netherlands.
Amory
Colum F
CF
Delman
Bradley N
BN
Kleinman
George M
GM
Lipsey
Lewis R
LR
Tuhrim
Stanley
S
D000368:Aged; D000792:Angiography / Q000379:methods; D001808:Blood Vessels / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D003072:Cognition Disorders / Q000209:etiology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods