Permanent modification of neurohormone expression in the hypothalamus of rats on the model of learned helplessness.
Depressive state of Wistar rats in the model of learned helplessness was accompanied by a persistent increase in the expression of corticotropin-releasing factor in the hypothalamus. Vasopressin content in the hypothalamus was modified only in the early poststress period and remained unchanged at the late stage of experimental depression. Our results indicate that hypothalamic corticotropin-releasing factor (but not vasopressin) plays an important role in the development of experimental mental disorders.
Mironova
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VI
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. viablos@mail.ru
Rybnikova
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EA
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D006380:Helplessness, Learned; D007031:Hypothalamus / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014667:Vasopressins / Q000378:metabolism*
D014667:Vasopressins; D003346:Corticotropin-Releasing Hormone