The lysosome and neurodegenerative diseases.
It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the lysosome is also involved in pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Abnormal protein degradation and deposition induced by lysosomal dysfunction may be the primary contributor to age-related neurodegeneration. In this review, the possible relationship between lysosome and various neurodegenerative diseases is described.
Zhang
Lisha
L
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215123, China.
Sheng
Rui
R
Qin
Zhenghong
Z
D006801:Humans; D008247:Lysosomes / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000503:physiopathology*