NMR metabolomics and drug discovery.
NMR is an integral component of the drug discovery process with applications in lead discovery, validation, and optimization. NMR is routinely used for fragment-based ligand affinity screens, high-resolution protein structure determination, and rapid protein-ligand co-structure modeling. Because of this inherent versatility, NMR is currently making significant contributions in the burgeoning area of metabolomics, where NMR is successfully being used to identify biomarkers for various diseases, to analyze drug toxicity and to determine a drug's in vivo efficacy and selectivity. This review describes advances in NMR-based metabolomics and discusses some recent applications.
Powers
Robert
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Department of Chemistry, University of Nebraska-Lincoln, 722 Hamilton Hall, Lincoln, NE 68588-0304, USA. rpowers3@unl.edu
D000818:Animals; D015415:Biomarkers / Q000737:chemistry; D055808:Drug Discovery; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D055432:Metabolomics; D011506:Proteins / Q000737:chemistry
D015415:Biomarkers; D011506:Proteins