High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats.
Electrical deep brain stimulation (DBS) is currently studied in the treatment of therapy-refractory obsessive compulsive disorders (OCDs). The variety of targeted brain areas and the inconsistency in demonstrating anti-compulsive effects, however, highlight the need for better mapping of brain regions in which stimulation may produce beneficial effects in OCD. Such a goal may be advanced by the assessment of DBS in appropriate animal models of OCD. Currently available data on DBS of the nucleus accumbens (NAc) on OCD-like behavior in rat models of OCD are contradictory and partly in contrast to clinical data and theoretical hypotheses about how the NAc might be pathophysiologically involved in the manifestation of OCD. Consequently, the present study investigates the effects of DBS of the NAc core and shell in a quinpirole rat model of OCD. The study demonstrates that electrical modulation of NAc core and shell activity via DBS reduces quinpirole-induced compulsive checking behavior in rats. We therefore conclude that both, the NAc core and shell constitute potential target structures in the treatment of OCD.
Mundt
Adrian
A
Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité University Medicine, Berlin, Germany.
Klein
Julia
J
Joel
Daphna
D
Heinz
Andreas
A
Djodari-Irani
Anais
A
Harnack
Daniel
D
Kupsch
Andreas
A
Orawa
Helmut
H
Juckel
Georg
G
Morgenstern
Rudolf
R
Winter
Christine
C
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D018491:Dopamine Agonists / Q000494:pharmacology; D004599:Electric Stimulation Therapy / Q000379:methods*; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology / Q000503:physiopathology; D009714:Nucleus Accumbens / Q000033:anatomy & histology / Q000187:drug effects / Q000503:physiopathology*; D009771:Obsessive-Compulsive Disorder / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy*; D019257:Quinpirole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D018491:Dopamine Agonists; D019257:Quinpirole; D004298:Dopamine