title: Simultaneous measurement of 23 plasma cytokines in late-life depression.
abstract: According to the cytokine hypothesis of depression, cytokines play key roles in the behavioral, neuroendocrinal, and neurochemical features of depression. In this study, we used a bioplex assay to simultaneously measure the levels of 23 plasma cytokines in 18 patients with late-life depression and 38 normal controls, and these levels were compared between the two groups. The plasma interleukin-1alpha (IL-1alpha) levels were found to be significantly different between the two groups. After adjusting for age, gender, low-density lipoprotein cholesterol, and triglyceride, the plasma IL-1alpha levels were significantly higher in the patients with late-life depression than in the normal control subjects. Thus, this study provides preliminary evidence that plasma IL-1alpha may play important roles in the pathogenesis of late-life depression.
authors.affiliation: Department of Psychiatry, Pochon CHA University College of Medicine, Seongnam, Korea.
authors.forename: Kang Soo
authors.initials: KS
authors.lastname: Lee
authors.forename: Ji Hyung
authors.initials: JH
authors.lastname: Chung
authors.forename: Kyung Hye
authors.initials: KH
authors.lastname: Lee
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Shin
authors.forename: Byoung Hoon
authors.initials: BH
authors.lastname: Oh
authors.forename: Soo Hyung
authors.initials: SH
authors.lastname: Lee
authors.forename: Chang Hyung
authors.initials: CH
authors.lastname: Hong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016207:Cytokines / Q000097:blood*; D003863:Depression / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000378:metabolism*
chemical_list: D016207:Cytokines