Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation.
This study characterized the contribution of bone marrow-derived cells to human neoplasia and the perineoplastic stroma. The Australasian Bone Marrow Transplant Recipient Registry was used to identify solid organ neoplasia that developed in female recipients of male allogeneic stem cell transplants. Eighteen suitable cases were identified including several skin cancers, two gastric cancers, and one rectal adenoma. Light microscopy, fluorescence and chromogenic in situ hybridization, and immunohistochemistry were performed to determine the nature and origin of the neoplastic and stromal cells. In contrast to recent reports, donor-derived neoplastic cells were not detected. Bone marrow-derived neoplasia-associated myofibroblasts, however, were identified in the rectal adenoma and in a gastric cancer. Bone marrow-derived cells can generate myofibroblasts in the setting of human gastrointestinal neoplasia.
Worthley
Daniel L
DL
Royal Brisbane and Women's Hospital Foundation Clinical Research Centre, Queensland Institute of Medical Research, Brisbane, Australia. daniel.worthley@uqconnect.edu.au
Ruszkiewicz
Andrew
A
Davies
Ruth
R
Moore
Sarah
S
Nivison-Smith
Ian
I
Bik To
L
L
Browett
Peter
P
Western
Robyn
R
Durrant
Simon
S
So
Jason
J
Young
Graeme P
GP
Mullighan
Charles G
CG
Bardy
Peter G
PG
Michael
Michael Z
MZ
D016026:Bone Marrow Transplantation / Q000009:adverse effects; D005260:Female; D005347:Fibroblasts / Q000473:pathology*; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology; D014184:Transplantation, Homologous