title: Chemical constituents from the aerial parts of Artemisia minor.
abstract: Four new compounds including three bicoumarins, arteminorins A-C (1-3), and one neolignan, arteminorin D (4), together with 31 known ones were isolated from the aerial parts of Artemisia minor. Their structures were established on the basis of spectroscopic data and comparison with those of the related known compounds. Ethyl caffeate (27) showed in vitro cytotoxicity against the HepG2 cancer cell line. Arteminorin C (3) and luteolin (19) showed inhibitory activity on xanthine oxidase (XOD), and caffeic acid (28) exhibited inhibitory activity on protein tyrosine phosphatase 1B (PTP1B).
authors.affiliation: National Engineering Research Center for Natural Medicines, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People's Republic of China.
authors.forename: Zhi-Zhou
authors.initials: ZZ
authors.lastname: He
authors.forename: Ju-Fang
authors.initials: JF
authors.lastname: Yan
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Song
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.forename: Xun
authors.initials: X
authors.lastname: Liao
authors.forename: Shu-Lin
authors.initials: SL
authors.lastname: Peng
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Ding
mesh_terms: D019306:Artemisia / Q000737:chemistry*; D002109:Caffeic Acids / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D018609:Tibet; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D002109:Caffeic Acids; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D017705:Lignans; C542213:arteminorin A; C542214:arteminorin B; C542215:arteminorin C; C542216:arteminorin D; D014969:Xanthine Oxidase; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1