Hypothermic effect of 5-HT1A receptor agonist: comparison of intranasal, intraperitoneal, and subcutaneous routes of administration.
The hypothermic effects of 5-HT1A serotonin receptor agonist 8-OH-DPAT after intranasal, intraperitoneal, and subcutaneous administration were compared. In a dose of 1 mg/kg 8-OH-DPAT induced similar thermal reactions after administration by all three routes. In a dose of 0.5 mg/kg 8-OH-DPAT caused no appreciable changes in body temperature after intraperitoneal injection and decreased it after subcutaneous and intranasal administration. No genotypic differences in the effects of 5-HT1A receptor agonist administered by different routes were detected in four inbred mouse strains.
Popova
N K
NK
Laboratory of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia. npopova@bionet.nsc.ru
Tibeikina
M A
MA
Amstislavskaya
T G
TG
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000008:administration & dosage*; D000281:Administration, Intranasal; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D007274:Injections, Intraperitoneal / Q000379:methods*; D007279:Injections, Subcutaneous / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D058829:Serotonin 5-HT1 Receptor Antagonists
D058829:Serotonin 5-HT1 Receptor Antagonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin