title: Additional HIV-1 mutation patterns associated with reduced phenotypic susceptibility to etravirine in clinical samples.
abstract: We investigated the phenotypic impact of a number of uncommon amino acid substitutions at HIV-1 reverse transcriptase positions 103 and 138, which are not part of the etravirine resistance score and were found in combination with the high-impact mutation K101P. Etravirine phenotypic fold changes were 380-1400 for K101P + E138A/G/Q + K103N/S/T + V179I and 12-130 for K101P + (K103S +/- V179I) in the absence of E138A/G/Q. Although the effect of K103S is unclear, additional position 138 substitutions seem important for etravirine susceptibility.
authors.affiliation: Department of Infectious Diseases, Quest Diagnostics Nichols Institute, San Juan Capistrano, California 92675, USA. kaganr@questdiagnostics.com
authors.forename: Ron M
authors.initials: RM
authors.lastname: Kagan
authors.forename: Prakash
authors.initials: P
authors.lastname: Sista
authors.forename: Theresa
authors.initials: T
authors.lastname: Pattery
authors.forename: Lee
authors.initials: L
authors.lastname: Bacheler
authors.forename: Dale A
authors.initials: DA
authors.lastname: Schwab
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral / Q000235:genetics; D005838:Genotype; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009570:Nitriles; D010641:Phenotype; D011724:Pyridazines / Q000494:pharmacology*; D011743:Pyrimidines
chemical_list: D019380:Anti-HIV Agents; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; C451734:etravirine; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase