title: Circulating sTWEAK improves the prediction of coronary artery disease.
abstract: OBJECTIVE
  Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance.
  
  
  METHODS
  The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects.
  
  
  RESULTS
  Serum sTWEAK concentrations were significantly lower in the patients (534.5+/-110.9 microg/L) than in the controls (688.1+/-150.0 microg/L, p<0.001), even after adjusting for different confounders (p<0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p=0.011-0.035).
  
  
  CONCLUSIONS
  The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers.
authors.affiliation: Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. zorana.jelic@pharmacy.bg.ac.rs
authors.forename: Zorana
authors.initials: Z
authors.lastname: Jelić-Ivanović
authors.forename: Nada
authors.initials: N
authors.lastname: Bujisić
authors.forename: Slavica
authors.initials: S
authors.lastname: Spasić
authors.forename: Natasa
authors.initials: N
authors.lastname: Bogavac-Stanojević
authors.forename: Vesna
authors.initials: V
authors.lastname: Spasojević-Kalimanovska
authors.forename: Jelena
authors.initials: J
authors.lastname: Kotur-Stevuljević
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D000074049:Cytokine TWEAK; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D048069:Tumor Necrosis Factors / Q000097:blood*
chemical_list: D015415:Biomarkers; D000074049:Cytokine TWEAK; C109743:TNFSF12 protein, human; D048069:Tumor Necrosis Factors