title: The role of computer-aided 3-dimensional analytic tools and virtual microscopy in the investigation of radiologic-pathologic correlation.
abstract: To cope with recent advances in radiologic imaging technology, a corresponding method for pathomorphologic demonstration should be developed to promote better understanding of radiologic-pathologic correlation. We attempted to obtain gross and microscopic images by using a 3-dimensional analytic tool and virtual microscopy and to link these images with multidetector computed tomography images. Surgically resected specimens were sliced to a thickness of 3 mm, and the digital images of each slice were 3-dimensionally reconstructed with RATOC TRI/3D SRF II software. Histology slides were digitized by using virtual microscopy with an Olympus VS-100. We obtained clear gross pathologic images in arbitrary cut sections of organs, and it was possible to rotate these 3-dimensional images at any angle. Furthermore, we created synchronous cut-section movies of computed tomography and gross pathologic images. Subsequently, we switched from these cut-section movies to virtual microscopy images by clicking on the hyperlink button to observe radiologic-pathologic correlation.
authors.affiliation: Department of Pathology, Ehime Prefectural Central Hospital, Matsuyama City, Japan. c-furuya@eph.pref.ehime.jp
authors.forename: Keizo
authors.initials: K
authors.lastname: Furuya
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Maeda
authors.forename: Seiji
authors.initials: S
authors.lastname: Nakanura
authors.forename: Takanori
authors.initials: T
authors.lastname: Kikuchi
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006338:Heart Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000000981:diagnostic imaging / Q000473:pathology; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D011859:Radiography