Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum.
Artemisone (single oral dose, 10 mg/kg of body weight) cured nonimmune Aotus monkeys of their Plasmodium falciparum infections when combined with mefloquine (single oral dose, 5 and 10 mg/kg but not 2.5 mg/kg). In combination with amodiaquine (20 mg/kg/day), artemisone (10 mg/kg/day) given orally for 3 days cured all infected monkeys. Three days of treatment with artemisone (30 mg/kg/day) and clindamycin (100 mg/kg/day) was also curative.
Obaldia
Nicanor
N
Tropical Medicine Research, Malaria Drug and Vaccine Evaluation Center/Gorgas Memorial Institute of Health Studies, Panama, Panama.
Kotecka
Barbara M
BM
Edstein
Michael D
MD
Haynes
Richard K
RK
Fugmann
Burkhard
B
Kyle
Dennis E
DE
Rieckmann
Karl H
KH
D000655:Amodiaquine / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D001029:Aotus trivirgatus; D037621:Artemisinins / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D016778:Malaria, Falciparum / Q000188:drug therapy*; D015767:Mefloquine / Q000627:therapeutic use; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000502:physiology*; D016896:Treatment Outcome
D000962:Antimalarials; D037621:Artemisinins; D000655:Amodiaquine; C514498:artemisone; D015767:Mefloquine