title: Electrochemical immunosensor for prostate-specific antigen using self-assembled oligophenylethynylenethiol monolayer containing dendrimer.
abstract: Electrochemical immunosensor for prostate-specific antigen (PSA) was fabricated with a self-assembled 4-(2-(4-(acetylthio)phenyl)ethynyl)benzoic acid (APBA) as a bioreceptor. In order to enhance the electrochemical activity of PSA detection, poly(amidoamine) dendrimer was linked on the APBA self-assembled monolayer (SAM). The formation and electrical properties of the SAMs were investigated by surface plasmon resonance and cyclic voltammetry, respectively. The surface morphology of PSA sandwich complex onto the APBA SAM was studied by atomic force microscopy.
authors.affiliation: Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul 121-742, Republic of Korea.
authors.forename: Mi-Ok
authors.initials: MO
authors.lastname: Namgung
authors.forename: Seul-Ki
authors.initials: SK
authors.lastname: Jung
authors.forename: Chan Moon
authors.initials: CM
authors.lastname: Chung
authors.forename: Se-Young
authors.initials: SY
authors.lastname: Oh
mesh_terms: D000480:Alkynes / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D050091:Dendrimers / Q000737:chemistry; D004560:Electricity; D004987:Ethers / Q000378:metabolism; D007118:Immunoassay / Q000379:methods; D018625:Microscopy, Atomic Force; D017430:Prostate-Specific Antigen / Q000032:analysis*; D020349:Surface Plasmon Resonance
chemical_list: D000480:Alkynes; D050091:Dendrimers; D004987:Ethers; C436384:phenyleneethynylene; D017430:Prostate-Specific Antigen