Clinical study of the efficiency of combined cell transplant on the basis of multipotent mesenchymal stromal adipose tissue cells in patients with pronounced deficit of the maxillary and mandibulary bone tissue.
The use of synthetic osteoplastic materials not always provides the required amount of the bone tissue. Transplantation of tissue-engineering constructs containing osteogenic precursor cells can be an alternative high-technology implantation method. Here we present the results of a pilot clinical study demonstrating safety of this method, accelerated healing of the operation wound, formation of young bone tissue after transplantation, and the possibility of mounting implants after 3 months in case of sufficient amount of the bone for primary fixation.
Kulakov
A A
AA
Central Research Institute of Dentistry and Oral Surgery, Federal Agency of Medical Technologies, Moscow. reception@chiis.ru
Goldshtein
D V
DV
Grigoryan
A S
AS
Rzhaninova
A A
AA
Alekseeva
I S
IS
Arutyunyan
I V
IV
Volkov
A V
AV
D000273:Adipose Tissue / Q000166:cytology*; D000328:Adult; D001847:Bone Diseases / Q000628:therapy*; D001842:Bone and Bones / Q000166:cytology; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000166:cytology; D008443:Maxillary Sinus / Q000601:surgery*; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology; D017154:Stromal Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*