Neuroprotective effects of estrogen therapy for cognitive and neurobiological profiles of monkey models of menopause.
Many postmenopausal women question whether to start or continue hormone therapy because of recent clinical trial negative results. However, evidence from other studies of postmenopausal women, and from studies in menopausal monkeys, indicate that estrogen has neurocognitive protective effects, particularly when therapy is initiated close to the time of menopause before neural systems become increasingly compromised with age. In this review, we present studies of menopausal women and female monkeys that support the concept that estrogen therapies protect both cognitive function and neurobiological processes.
Voytko
Mary Lou
ML
Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. mlvoytko@wfubmc.edu
Tinkler
Gregory Paul
GP
Browne
Carole
C
Tobin
Joseph R
JR
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D003071:Cognition / Q000187:drug effects*; D015914:Estrogen Replacement Therapy / Q000706:statistics & numerical data*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008593:Menopause / Q000378:metabolism*; D023421:Models, Animal; D018696:Neuroprotective Agents / Q000494:pharmacology*; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D013569:Synapses / Q000187:drug effects*
D004967:Estrogens; D018696:Neuroprotective Agents; D017981:Receptors, Neurotransmitter