Evaluation for skin sensitization based on published literatures (existing information) of major PRTR designated chemical substances in Japan.
Of the 354 substances designated as class I under the Pollutant Release and Transfer Register (PRTR) law in Japan, we reviewed the sensitization data of the selected 144 substances and analyzed it from various aspects comparing human and animal data, determining the relationship between skin sensitization and chemical structure and comparing the various international organizations. Although most of them were expected to be hazardous substances, 49 out of the 144 substances lacked both human and animal sensitization data. Positive substances accounted for 69% and 42% of the substances for which sensitization data were available in the case of humans and animals, respectively. A correlation was observed between the chemical structures of the substances and sensitization, despite the relatively few substances examined in this study and the limited homogeneity of the collected data. In particular, epoxides clearly had sensitizing potentials and more than half of carboxylic esters or dicarboxyl anhydrides, aliphatic aldehydes, and aromatic compounds with at least two hydroxyl groups also had sensitizing potentials. Also, this study clearly demonstrated the lack of consistency across the sensitization assessment criteria adopted by different countries or among those adopted by the same country on the basis of different laws or administrative measures.
Ishii
Satoko
S
Chemicals Evaluation and Research Institute, Japan, Chemicals Assessment and Research Center, 1-4-25 Kouraku, Bunkyou-ku, Tokyo 112-0004, Japan. ishii-satoko@ceri.jp
Ishii
Kaori
K
Imatanaka
Nobuya
N
Fujino
Yoshifumi
Y
Sasaki
Keiichi
K
Nakadate
Masahiro
M
D000485:Allergens / Q000737:chemistry / Q000145:classification / Q000633:toxicity*; D000818:Animals; D004785:Environmental Pollutants / Q000737:chemistry / Q000145:classification / Q000633:toxicity*; D014943:Global Health; D015386:Hazardous Substances / Q000145:classification / Q000633:toxicity*; D006801:Humans; D007390:International Agencies / Q000592:standards; D007564:Japan; D012042:Registries; D012867:Skin / Q000187:drug effects; D012882:Skin Tests / Q000592:standards*; D013329:Structure-Activity Relationship
D000485:Allergens; D004785:Environmental Pollutants; D015386:Hazardous Substances