Simian foamy virus infection in humans: prevalence and management.
Simian foamy viruses (SFVs) are highly prevalent in all nonhuman primate species and can infect humans following occupational and non-occupational exposure to infected animals and their tissues, blood or body fluids. Virus transmission results in a stable, persistent infection that seems to be latent. SFV infections are thus far nonpathogenic, with no evidence of adverse clinical outcome in their natural nonhuman primate hosts or by experimental injection in animals and upon cross-species transmission in humans. Since the emergence of pathogenic viruses from nonpathogenic viruses upon cross-species infection is well-documented for several retroviruses, it is prudent to take necessary precautions to deter SFV infections in humans. These steps will help prevent the emergence of a novel pathogen and reduce the risk of transmission of another potential pathogenic human retrovirus.
Khan
Arifa S
AS
Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation & Research, US Food & Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA. arifa.khan@fda.hhs.gov
D000818:Animals; D006801:Humans; D010802:Phylogeny; D018419:Primate Diseases / Q000635:transmission / Q000821:virology; D011323:Primates / Q000821:virology; D012192:Retroviridae Infections / Q000453:epidemiology* / Q000517:prevention & control* / Q000635:transmission / Q000662:veterinary; D053150:Simian foamy virus / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D013045:Species Specificity; D015047:Zoonoses / Q000453:epidemiology / Q000635:transmission