title: Swim training suppresses tumor growth in mice.
abstract: The present study was designed to determine the effects of physical training on the development of cancer induced by the injection of Ehrlich tumor cells in mice. Male Swiss mice were subjected to a swim training protocol (5 days/wk for 6 wk, 1 h at 50% of maximal capacity-trained groups) or remained sedentary in their cages (sedentary groups). The inoculation of Ehrlich tumor cells was performed at the end of the fourth week, and animals were killed after 6 wk of training. Heart and solid tumor weights were recorded, and tumor volumes were calculated. Portions of the tumors were used for the evaluation of macrophages and neutrophil accumulation or fixed in neutral 10% buffered formalin for histological analysis. The tumor volume and weight were, respectively, approximately 270% and 280% greater in sedentary mice than in trained mice. Macrophage infiltration in the tumor tissue was significantly lower in trained mice (0.65 +/- 0.16 vs. 1.78 +/- 0.43 macrophages x 10(3) in the sedentary group). Moreover, neutrophil accumulation in tumors was slightly reduced after exercise training, and the amount of tumor cells was reduced in trained mice. Exercise capacity was substantially increased in trained mice, as determined by a 440% increase in the exercise time at 50% of maximal capacity. In summary, swim training retarded the development of Ehrlich tumors in mice, accompanied by a reduction in macrophage infiltration and neutrophil accumulation. These findings provide conceptual support for clinical observations that controlled physical activities may be a therapeutically important approach to preventing cancer progression and may improve the outcome of cancer treatment.
authors.affiliation: Department of Environmental, Biological and Health Sciences, University Center of Belo Horizonte, Belo Horizonte, MG, Brazil.
authors.forename: Pedro William M
authors.initials: PW
authors.lastname: Almeida
authors.forename: Ary
authors.initials: A
authors.lastname: Gomes-Filho
authors.forename: Anderson J
authors.initials: AJ
authors.lastname: Ferreira
authors.forename: Carlos Eduardo M
authors.initials: CE
authors.lastname: Rodrigues
authors.forename: Marco Fabrício
authors.initials: MF
authors.lastname: Dias-Peixoto
authors.forename: Remo C
authors.initials: RC
authors.lastname: Russo
authors.forename: Mauro M
authors.initials: MM
authors.lastname: Teixeira
authors.forename: Geovanni D
authors.initials: GD
authors.lastname: Cassali
authors.forename: Enio
authors.initials: E
authors.lastname: Ferreira
authors.forename: Ivan C
authors.initials: IC
authors.lastname: Santos
authors.forename: Alessandra M C
authors.initials: AM
authors.lastname: Garcia
authors.forename: Emerson
authors.initials: E
authors.lastname: Silami-Garcia
authors.forename: Ulrik
authors.initials: U
authors.lastname: Wisløff
authors.forename: Guilherme A
authors.initials: GA
authors.lastname: Pussieldi
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology / Q000628:therapy*; D004195:Disease Models, Animal; D005081:Exercise Therapy / Q000379:methods*; D008264:Macrophages / Q000473:pathology; D008297:Male; D051379:Mice; D020556:Neutrophil Infiltration / Q000502:physiology; D009504:Neutrophils / Q000473:pathology; D009929:Organ Size; D010805:Physical Conditioning, Animal; D013550:Swimming / Q000502:physiology*