title: Synthesis and microcontact printing of dual end-functionalized mucin-like glycopolymers for microarray applications.
abstract: Click to view: Glycopolymers can be used to display glycans on microarrays in native-like architectures. The structurally uniform alkyne-terminated mucin mimetic glycopolymers (see picture; TR = fluorophore) were printed on azide-functionalized chips by microcontact printing in the presence of a copper catalyst. The surface-bound glycopolymers bind lectins in a ligand-specific manner.
authors.affiliation: Department of Chemistry, University of California and The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
authors.forename: Kamil
authors.initials: K
authors.lastname: Godula
authors.forename: David
authors.initials: D
authors.lastname: Rabuka
authors.forename: Ki Tae
authors.initials: KT
authors.lastname: Nam
authors.forename: Carolyn R
authors.initials: CR
authors.lastname: Bertozzi
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry; D006023:Glycoproteins / Q000737:chemistry; D037102:Lectins / Q000737:chemistry*; D046228:Microarray Analysis; D009077:Mucins / Q000737:chemistry*; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D005456:Fluorescent Dyes; D006023:Glycoproteins; D037102:Lectins; D009077:Mucins; D011134:Polysaccharides