Vitamin A and vitamin B-12 concentrations in relation to mortality and morbidity among children born to HIV-infected women.
Vitamin A supplementation starting at 6 months of age is an important child survival intervention; however, not much is known about the association between vitamin A status before 6 months and mortality among children born to HIV-infected women. Plasma concentrations of vitamins A and B-12 were available at 6 weeks of age (n = 576 and 529, respectively) for children born to HIV-infected women and they were followed up for morbidity and survival status until 24 months after birth. Children in the highest quartile of vitamin A had a 49% lower risk of death by 24 months of age compared to the lowest quartile (HR: 0.51, 95% CI: 0.29-0.90; P-value for trend = 0.01). Higher vitamin A levels were protective in the sub-groups of HIV-infected and un-infected children but this was statistically significant only in the HIV-uninfected subgroup. Higher vitamin A concentrations in plasma are protective against mortality in children born to HIV-infected women.
Chatterjee
Anirban
A
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. achatterjee24@post.harvard.edu
Bosch
Ronald J
RJ
Hunter
David J
DJ
Manji
Karim
K
Msamanga
Gernard I
GI
Fawzi
Wafaie W
WW
D002675:Child, Preschool; D019587:Dietary Supplements / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications / Q000401:mortality* / Q000635:transmission; D015497:HIV-1; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D009017:Morbidity; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D016019:Survival Analysis; D013636:Tanzania / Q000453:epidemiology; D014801:Vitamin A / Q000008:administration & dosage / Q000097:blood*; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000097:blood*; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000097:blood*; D014815:Vitamins / Q000008:administration & dosage / Q000097:blood*
D014815:Vitamins; D014801:Vitamin A; D014803:Vitamin B Complex; D014805:Vitamin B 12