Implications of cytokine gene polymorphisms on the orchestration of the immune response: lessons learned from oral diseases.
Over the past 10 years, a plethora of information concerning the influence of gene polymorphisms on cytokine expression has been made available in the literature. Significant contribution to this field has come from studies of oral diseases, one of the widest spread health problems in the world, affecting hundreds of millions worldwide. Here we will discuss the importance of studies of gene polymorphism towards the identification of susceptible groups or prognostic indicators of oral disease. Additionally, we will highlight the differences in data obtained from genetically diverse populations and review the application of cytokine gene polymorphisms studies in oral diseases in autoimmune processes and parasitic infections.
Dutra
Walderez O
WO
Laboratory of Cell-Cell Interactions, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, CEP 31270-901, Belo Horizonte-MG, Brazil. waldutra@gmail.com
Moreira
Paula R
PR
Souza
Paulo Eduardo A
PE
Gollob
Kenneth J
KJ
Gomez
Ricardo S
RS
D016207:Cytokines / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007111:Immunity, Cellular; D008954:Models, Biological; D009059:Mouth Diseases / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D010510:Periodontal Diseases / Q000235:genetics / Q000276:immunology / Q000473:pathology; D011110:Polymorphism, Genetic
D016207:Cytokines