Synthesis and antiviral activity of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) against peste des petits ruminant virus (PPRV).
An efficient and eco-friendly method for the synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) has been accomplished by tandem Knoevenagel-Michael reaction of two equivalents of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one with various aromatic aldehydes catalyzed by ceric ammonium nitrate (CAN) in water. All the synthesized compounds 3a-j were evaluated for in vitro antiviral activity against peste des petits ruminant virus (PPRV). Compound 3i emerged as the most interesting compound in this series exhibiting excellent antiviral activity against PPRV and found to be more potent than the standard drug ribavirin used.
Sujatha
Kuppusamy
K
Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai 600 116, India.
Shanthi
Gnanamani
G
Selvam
Nagarajan Panneer
NP
Manoharan
Seeralan
S
Perumal
Paramasivan T
PT
Rajendran
Melani
M
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002563:Cerium / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002522:Chlorocebus aethiops; D015195:Drug Design; D008956:Models, Chemical; D029021:Peste-des-Petits-Ruminants / Q000188:drug therapy*; D018107:Peste-des-petits-ruminants virus / Q000378:metabolism*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D012254:Ribavirin / Q000494:pharmacology; D014709:Vero Cells; D014867:Water / Q000737:chemistry
D000998:Antiviral Agents; D011720:Pyrazoles; D014867:Water; D002563:Cerium; D012254:Ribavirin; C004653:ceric ammonium nitrate