Anti-inflammatory and anticancer activity of ergoflavin isolated from an endophytic fungus.
Biodiversity is a major resource for identification of new molecules with specific therapeutic activities. To identify such an active resource, high throughput screening (HTS) of the extracts prepared from such diversity are examined on specific functional assays. Based on such HTS studies and bioactivity-based fractionation, we have isolated ergoflavin, a pigment from an endophytic fungus, growing on the leaves of an Indian medicinal plant Mimosops elengi (bakul). We report here the isolation, structure elucidation, and biological properties of this compound, which showed good anti-inflammatory and anticancer activities.
Deshmukh
Sunil Kumar
SK
Piramal Life Sciences Limited, 1 Nirlon Complex, Off Western Express Highway, Near NSE Complex, Goregaon (East), Mumbai, India. sunil.deshmukh@piramal.com
Mishra
Prabhu Dutt
PD
Kulkarni-Almeida
Asha
A
Verekar
Shilpa
S
Sahoo
Manas Ranjan
MR
Periyasamy
Giridharan
G
Goswami
Hitesh
H
Khanna
Amit
A
Balakrishnan
Arun
A
Vishwakarma
Ram
R
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032130:Mimusops / Q000382:microbiology; D018515:Plant Leaves / Q000382:microbiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D002867:Chromones; D015850:Interleukin-6; D007783:Lactones; D014409:Tumor Necrosis Factor-alpha; C542671:ergoflavin