Endometrium from women with endometriosis shows increased proliferation activity.
Examination of 631 infertile women, including 434 women with endometriosis and 197 without endometriosis, revealed an increasing incidence of endometrial polyps, especially in the test subjects with endometriosis, and advanced stages of endometriosis. Expression of Ki-67 and Bcl-2 proteins and MTT assay results were significantly higher in endometrium of patients with endometriosis than in patients without endometriosis. These showed increased proliferation activity and cell proliferation markers not only clinically but also pathologically.
Park
Jae Sun
JS
Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea.
Lee
Jae Hoon
JH
Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea; Department of Biological Science, College of Natural Science, Ajou University, Suwon, South Korea.
Kim
Miran
M
Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea. Electronic address: kmr5300@ajou.ac.kr.
Chang
Hye Jin
HJ
Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea.
Hwang
Kyung Joo
KJ
Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea.
Chang
Ki Hong
KH
Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea.
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D049109:Cell Proliferation; D004715:Endometriosis / Q000378:metabolism / Q000473:pathology*; D004717:Endometrium / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D011127:Polyps / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D014591:Uterine Diseases / Q000378:metabolism / Q000473:pathology*
D015415:Biomarkers; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2