title: Glaucoma filtration surgery and retinal oxygen saturation.
abstract: OBJECTIVE
  Glaucoma may involve disturbances in retinal oxygenation and blood flow. The purpose of this study was to measure the effect of glaucoma filtration surgery on retinal vessel oxygen saturation.
  
  
  METHODS
  A noninvasive spectrophotometric retinal oximeter was used to measure hemoglobin oxygen saturation in retinal arterioles and venules before and after glaucoma filtration surgery. Twenty-five consecutive patients were recruited, and 19 had adequate image quality. Fourteen underwent trabeculectomy and five glaucoma tube surgery. Twelve had primary open-angle glaucoma and seven had exfoliative glaucoma. IOP decreased from 23 +/- 7 to 10 +/- 4 mm Hg (mean +/- SD, P = 0.0001).
  
  
  RESULTS
  Oxygen saturation increased in retinal arterioles from 97% +/- 4% to 99% +/- 6% (n = 19; P = 0.046) after surgery and was unchanged in venules (63% +/- 5% before surgery and 64% +/- 6% after, P = 0.76). There were no significant changes in saturation in the fellow eyes (P > 0.60). The arteriovenous difference was 34% before and 36% after surgery (P = 0.35).
  
  
  CONCLUSIONS
  Glaucoma filtration surgery had almost no effect on retinal vessel oxygen saturation.
authors.affiliation: Department of Ophthalmology, University of Iceland/Landspítali-University Hospital, Reykjavik, Iceland.
authors.forename: Sveinn Hakon
authors.initials: SH
authors.lastname: Hardarson
authors.forename: Maria Soffia
authors.initials: MS
authors.lastname: Gottfredsdottir
authors.forename: Gisli Hreinn
authors.initials: GH
authors.lastname: Halldorsson
authors.forename: Robert Arnar
authors.initials: RA
authors.lastname: Karlsson
authors.forename: Jon Atli
authors.initials: JA
authors.lastname: Benediktsson
authors.forename: Thor
authors.initials: T
authors.lastname: Eysteinsson
authors.forename: James M
authors.initials: JM
authors.lastname: Beach
authors.forename: Alon
authors.initials: A
authors.lastname: Harris
authors.forename: Einar
authors.initials: E
authors.lastname: Stefansson
mesh_terms: D000368:Aged; D005260:Female; D020327:Glaucoma Drainage Implants; D005902:Glaucoma, Open-Angle / Q000097:blood* / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000032:analysis; D012039:Regional Blood Flow / Q000502:physiology; D012171:Retinal Vessels / Q000378:metabolism*; D014130:Trabeculectomy
chemical_list: D010108:Oxyhemoglobins; D010100:Oxygen