Alpha-chiral acetylenes having an all-carbon quaternary center: phase transfer catalyzed enantioselective alpha alkylation of alpha-alkyl-alpha-alkynyl esters.
Going through the phases: The title reaction was found to proceed by an initial base-mediated isomerization to allenyl esters and subsequent phase transfer catalyzed alkylation at the alpha position of the ester (see scheme).
Hashimoto
Takuya
T
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, 606-8502, Japan.
Sakata
Kazuki
K
Maruoka
Keiji
K