Generality of a power-law long-term correlation in beat timings of single cardiac cells.
Statistical properties of spontaneous contractions of atrial muscle cells were examined and compared to those of ventricular muscle cells. The cells derived from atria of neonatal rats exhibit spindle morphology, and they were found to express alpha-smooth muscle actin and hyperpolarization-activated cation channel 4, both of which are known marker of neonatal atrial muscle cells. The short-term properties of spontaneous contractions of atrial cells, characterized by considerably large beat rate and absence of bursts, are distinct from those of ventricular muscle cells. Despite of these differences, the long-term properties of the beat-rate fluctuations exhibit a remarkable similarity to those of ventricular cells. In particular, the presence of power-law correlation characterized as 1/f(beta) noise (beta approximately 1) was also confirmed for atrial cells for the first time. The observed similarity of the long-term characteristics of beat-rate fluctuation suggests the presence of a general regulatory mechanism of the cellular function.
Yokogawa
Tomomi
T
Department of Human and Artificial Intelligent Systems, University of Fukui, Fukui, Japan.
Harada
Takahiro
T
D000199:Actins / Q000378:metabolism; D000818:Animals; D016275:Atrial Function / Q000502:physiology*; D002469:Cell Separation; D002478:Cells, Cultured; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000378:metabolism; D006325:Heart Atria / Q000166:cytology*; D006339:Heart Rate; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000502:physiology*; D051381:Rats
D000199:Actins; D054815:Cyclic Nucleotide-Gated Cation Channels; C498862:Acta2 protein, rat