title: Effect of a tart cherry juice blend on exercise-induced muscle damage in horses.
abstract: OBJECTIVE
  To evaluate whether administering a tart cherry juice blend (TCJB) prior to exercise would reduce skeletal and cardiac muscle damage by decreasing the inflammatory and oxidative stress response to exercise in horses.
  
  
  METHODS
  6 horses.
  
  
  METHODS
  Horses were randomly allocated into 2 groups in a crossover study with a 2-week washout period and orally administered either TCJB or a placebo solution (1.42 L, twice daily) in a double-masked protocol for 2 weeks prior to a stepwise incremental exercise protocol. Horses were tested for serum activities of creatine kinase and aspartate aminotransferase (AST) and concentrations of cardiac troponin I (cTnI), thiobarbituric acid reactive substances (TBARS; an indicator of oxidative stress), and serum amyloid A (SAA; an indicator of inflammation). To ensure that treatment would not result in positive results of an equine drug-screening protocol, serum samples obtained from each horse prior to and after 2 weeks of administration of TCJB or the placebo solution were tested.
  
  
  RESULTS
  All horses had negative results of drug screening at both sample times. The exercise protocol resulted in a significant increase in TBARS concentration, SAA concentration, and serum AST activity in all horses. Administration of TCJB or placebo solution was not associated with an effect on malondialdehyde or SAA concentrations. However, administration of TCJB was associated with less serum activity of AST, compared with administration of placebo solution.
  
  
  CONCLUSIONS
  Administration of TCJB may diminish muscle damage induced by exercise.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Normand G
authors.initials: NG
authors.lastname: Ducharme
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Fortier
authors.forename: Marc S
authors.initials: MS
authors.lastname: Kraus
authors.forename: Seiji
authors.initials: S
authors.lastname: Hobo
authors.forename: Hussni O
authors.initials: HO
authors.lastname: Mohammed
authors.forename: Malachy P
authors.initials: MP
authors.lastname: McHugh
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hackett
authors.forename: Leo V
authors.initials: LV
authors.lastname: Soderholm
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Mitchell
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D018592:Cross-Over Studies; D019587:Dietary Supplements; D005260:Female; D005638:Fruit / Q000737:chemistry*; D006736:Horses / Q000502:physiology*; D018482:Muscle, Skeletal / Q000187:drug effects*; D010805:Physical Conditioning, Animal; D028321:Plant Preparations / Q000627:therapeutic use; D027861:Prunus / Q000737:chemistry*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D019210:Troponin I / Q000097:blood
chemical_list: D028321:Plant Preparations; D017392:Thiobarbituric Acid Reactive Substances; D019210:Troponin I; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase