title: Acute pancreatitis in a girl with panhypopituitarism due to craniopharyngioma on growth hormone treatment. A combination of risk factors.
abstract: Craniopharyngioma is a rare, benign, suprasellar brain tumor associated with a significant number of endocrine and metabolic impairments. Growth hormone deficiency, caused by the tumor itself or by its subsequent surgical treatment, is the most common hormone deficiency in these patients and replacement is frequently necessary. Hypothalamic obesity observed after surgery treatment, whether combined with radiotherapy or not, presents with increased abdominal fat and altered lipid profiles and is likely caused by both disruption of the mechanisms controlling satiety, hunger and energy balance and impairment of sensitivity to leptin, insulin and ghrelin axis. It is well known that hyperlipemia is associated with acute pancreatitis, both as a precipitant and as an epiphenomenon. Moreover, the increased incidence of acute pancreatitis during growth hormone therapy is possibly due to increased enzyme production (e.g., amylase, lipase and elastase). We report the case of a 13-year-old girl affected by craniopharyngioma on growth hormone replacement treatment who developed acute pancreatitis. We suggest including routine evaluation of lipid profile during follow-up of all children on growth hormone treatment, especially those affected by hypopituitarism secondary to craniopharyngioma, given pancreatic adverse effects of growth hormone replacement therapy and associated metabolic impairment due to hypothalamic obesity.
authors.affiliation: Department of Biomedicine of Developmental Age, University of Bari, Bari, Italy. mf.faienza@endobiomol.uniba.it
authors.forename: Maria Felicia
authors.initials: MF
authors.lastname: Faienza
authors.forename: Maurizio
authors.initials: M
authors.lastname: Delvecchio
authors.forename: Flavia
authors.initials: F
authors.lastname: Indrio
authors.forename: Ruggiero
authors.initials: R
authors.lastname: Francavilla
authors.forename: Angelo
authors.initials: A
authors.lastname: Acquafredda
authors.forename: Luciano
authors.initials: L
authors.lastname: Cavallo
mesh_terms: D000293:Adolescent; D000681:Amylases / Q000097:blood; D003397:Craniopharyngioma / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005215:Fasting / Q000097:blood; D005260:Female; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008049:Lipase / Q000097:blood; D008055:Lipids / Q000097:blood; D010195:Pancreatitis / Q000097:blood / Q000139:chemically induced*; D011994:Recombinant Proteins / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D008055:Lipids; D011994:Recombinant Proteins; D019382:Human Growth Hormone; D008049:Lipase; D000681:Amylases