title: Intraspecies signaling involving the diffusible signal factor BDSF (cis-2-dodecenoic acid) influences virulence in Burkholderia cenocepacia.
abstract: Burkholderia cenocepacia produces a diffusible fatty acid signal molecule, cis-2-dodecenoic acid (BDSF), that has been implicated in interspecies and interkingdom communication. Here, we show that BDSF also acts as an intraspecies signal in B. cenocepacia to control factors contributing to virulence of this major opportunistic pathogen.
authors.affiliation: BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, University College Cork, Cork, Ireland.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Ryan
authors.forename: Yvonne
authors.initials: Y
authors.lastname: McCarthy
authors.forename: Steven A
authors.initials: SA
authors.lastname: Watt
authors.forename: Karsten
authors.initials: K
authors.lastname: Niehaus
authors.forename: J Maxwell
authors.initials: JM
authors.lastname: Dow
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D019121:Burkholderia Infections / Q000382:microbiology; D016956:Burkholderia cepacia / Q000187:drug effects / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism* / Q000494:pharmacology; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects / Q000235:genetics; D005816:Genetic Complementation Test; D007814:Larva / Q000382:microbiology; D009036:Moths / Q000382:microbiology; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D014774:Virulence / Q000187:drug effects / Q000235:genetics
chemical_list: C527562:2-dodecenoic acid; D001426:Bacterial Proteins; D005229:Fatty Acids, Monounsaturated