Increased inositol phosphoglycan P-type in the second trimester in pregnant women with type 2 and gestational diabetes mellitus.
A progressive insulin resistant state develops throughout human pregnancy. Inositol phosphoglycan P-type (P-IPG), a second messenger of insulin, was reported to negatively correlate with the degree of insulin resistance in non-pregnant diabetic subjects. Urinary levels of P-IPG were assessed in insulin resistant states during pregnancy such as gestational diabetes mellitus (GDM, n=44) and type 2 diabetes mellitus (type 2 DM, n=25) and in 69 normal pregnant women. Urinary levels of P-IPG were higher in GDM than controls with a positive trend of release throughout normal pregnancy (P<0.01). P-IPG excretion was higher in diabetic (GDM and type 2 DM) than in healthy women in the second trimester (P<0.05). A higher P-IPG urinary excretion occurs during the second trimester in pregnant women with clinically evident insulin resistance with a positive association with poor glycemic control.
Scioscia
Marco
M
Department of Immunology and Molecular Pathology, Molecular Medicine Unit, Royal Free and University College Medical School, London, UK. marcoscioscia@gmail.com
Gumaa
Khalid
K
Selvaggi
Luigi E
LE
Rodeck
Charles H
CH
Rademacher
Thomas W
TW
D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000652:urine*; D016640:Diabetes, Gestational / Q000097:blood / Q000473:pathology / Q000652:urine*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007295:Inositol Phosphates / Q000652:urine*; D007333:Insulin Resistance / Q000502:physiology; D010865:Pilot Projects; D011134:Polysaccharides / Q000652:urine*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011254:Pregnancy in Diabetics / Q000097:blood / Q000473:pathology / Q000652:urine*
D001786:Blood Glucose; D007295:Inositol Phosphates; D011134:Polysaccharides; C028039:inositol phosphate glycan