Dynamic of pneumococcal nasopharyngeal carriage in children with acute otitis media following PCV7 introduction in France.
To determine whether the use of seven valent pneumococcal conjugate vaccine (PCV7) caused a shift in the Streptococcus pneumoniae serotypes distribution and whether it modified the resistance to antibiotics, 3291 nasopharyngeal swabs were obtained between 2001 and 2006, from children aged 6-24 months with acute otitis media. Following the implementation of PCV7, we observed a slight reduction in the overall pneumococcal carriage, a marked decrease of vaccine serotypes, an increase in non-vaccine serotypes carriage and a reduction in the carriage of penicillin non-susceptible strains. Most of the serotype 19A replacement was related to the clonal expansion of ST276 which was found to be the predominant ST among penicillin non-susceptible isolates.
Cohen
R
R
Département de Microbiologie, Centre Hospitalier Intercommunal de Créteil, Service de Microbiologie, 40 avenue de Verdun, 94 000 Créteil, France. robert.cohen@wanadoo.fr
Levy
C
C
Bonnet
E
E
Grondin
S
S
Desvignes
V
V
Lecuyer
A
A
Fritzell
B
B
Varon
E
E
D002353:Carrier State / Q000276:immunology / Q000517:prevention & control*; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D005602:France; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000382:microbiology*; D010033:Otitis Media / Q000276:immunology*; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011159:Population Surveillance; D011446:Prospective Studies; D012307:Risk Factors; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology
D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate