Preparation, physicochemical characterization and biological evaluation of cefodizime metal ion complexes.
OBJECTIVE
Cefodizime is a broad spectrum cephalosporin belonging to the third generation agents. In this study, attention has been paid to the preparation, physicochemical characterization and biological evaluation of new Cu2+, Zn2+, Fe3+, Co2+ and Al3+ complexes of cefodizime.


METHODS
The stoichiometrics and the mode of bonding of the complexes were deduced from their elemental and metal analysis, electrical conductivity measurements, UV-vis, infrared and Raman spectroscopic investigations. Study of the stoichiometry of these complexes referred to the formation of 1 : 1 ratios of metal to ligand. Antimicrobial activity of the complexes was determined using two strains of Gram-positive (Bacillus subtilis and Proteus vulgaris) and two strains of Gram-negative (Escherichia coli W3110 and Pseudomonas putida) bacteria. The minimal inhibitory concentration was determined as the lowest concentration inhibiting bacterial growth on solid Luria Bertani medium.


RESULTS
The spectra gave evidence as to the position of binding. In addition, the aqueous solubility of cefodizime was strongly reduced by complexation.


CONCLUSIONS
The antibacterial activity of cefodizime was not affected by complexation with Al3+ but it was reduced by complexation with the other tested metal ions against the bacteria under study.
Auda
Sayed H
SH
Institutes of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Mrestani
Yahya
Y
Nies
Dietrich H
DH
Grosse
Cornelia
C
Neubert
Reinhard H H
RH
D000535:Aluminum / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D007501:Iron / Q000737:chemistry; D019216:Metals, Heavy / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D015032:Zinc / Q000737:chemistry
D000900:Anti-Bacterial Agents; D019216:Metals, Heavy; D003035:Cobalt; D003300:Copper; D000535:Aluminum; D007501:Iron; D015032:Zinc; D002439:Cefotaxime; C033356:cefodizime