title: H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.
abstract: Screening of Salmonella mutants for the ability to increase beta-lactam resistance has led to the identification of a mutation in hns, which codes for the histone-like nucleoid structuring protein (H-NS). In this study, we report that H-NS modulates multidrug resistance through repression of the genes that encode the AcrEF multidrug efflux pump in Salmonella enterica serovar Typhimurium.
authors.affiliation: Laboratory of Microbiology and Infectious Diseases, Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Osaka 567-0047, Japan. nishino@sanken.osaka-u.ac.jp
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Nishino
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Hayashi-Nishino
authors.forename: Akihito
authors.initials: A
authors.lastname: Yamaguchi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics / Q000502:physiology; D026901:Membrane Transport Proteins / Q000235:genetics / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D047090:beta-Lactams