title: Laser-guidance based detection of cells with single-gene modification.
abstract: An optical method with single-gene sensitivity for cell detection based on laser guidance was explored. Guided by the optical force from a weakly focused laser beam, a cell will move along the laser axis. Cells with different properties experience different optical forces and thus guidance speeds. The guidance speeds of the TC-1 cell and its genetically modified counterpart with only one gene change, L-10 cell, were studied under the same conditions. The results demonstrated that this laser guidance-based speed-measurement method can precisely distinguish cells that differ by only one gene.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Ma
authors.forename: Karen J L
authors.initials: KJ
authors.lastname: Burg
authors.forename: Yanzhang
authors.initials: Y
authors.lastname: Wei
authors.forename: X-C
authors.initials: XC
authors.lastname: Yuan
authors.forename: Xiang
authors.initials: X
authors.lastname: Peng
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Gao