Exposure to formaldehyde induces heritable DNA mutations in mice.
Our recent studies showed that exposure to mixed indoor air pollutants in a newly decorated residential apartment induced expanded simple tandem repeats (ESTR) mutations in mice, and the mutations were mainly inherited from the paternal germ line. Formaldehyde (FA) is a type of major volatile organic chemical (VOC) present in indoor air, and a constituent known to be associated with sick building syndrome. In the present study, mice were exposed to different concentrations of FA (0, 2, 20, or 200 mg/m(3)). The germline mutations were detected in their offspring using three ESTR probes, Ms6-hm, Hm-2, and MMS10. Data indicated that mice exposed to 200 mg/m(3) FA demonstrated a significant elevation in ESTR mutations, which is due primarily to an increase in mutations inherited through the paternal germ line. These results suggest that FA induced ESTR mutations in mice. It is postulated that single FA exposure might be a useful model to identify indoor air mixture exposure-induced heritable DNA damage.
Liu
Yun-Ru
YR
Department of Molecular Cell Biology and Toxicology, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Zhou
Yin
Y
Qiu
Wen
W
Zeng
Jin-Yan
JY
Shen
Lian-Lian
LL
Li
Ai-Ping
AP
Zhou
Jian-Wei
JW
D000818:Animals; D042622:DNA Repeat Expansion / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005557:Formaldehyde / Q000009:adverse effects*; D018095:Germ-Line Mutation / Q000187:drug effects*; D008297:Male; D051379:Mice
D005557:Formaldehyde