Immune reactions in the progeny of female rats treated with paclitaxel.
Immune reactions of the progeny of female Wistar rats injected with paclitaxel a single MPD of 1 and 3 months before mating with intact males were studied. Thymic hyperplasia was detected in the progeny of female rats mated 1 month after treatment. Disorders in the antibody-specific and antibody-nonspecific mechanisms of the immune response were detected in the progeny of females mated with intact males 3 months after cytostatic treatment.
Sherstoboev
E Y
EY
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. ach@pharm.tsu.ru
Borovskaya
T G
TG
Goldberg
V E
VE
Masnaya
N V
NV
Borsuk
O S
OS
Daniletz
M G
MG
Pachomova
A V
AV
Perova
A V
AV
Goldberg
E D
ED
D000818:Animals; D000831:Animals, Newborn; D054697:Cytostatic Agents / Q000633:toxicity; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D007109:Immunity / Q000187:drug effects* / Q000276:immunology; D008297:Male; D017239:Paclitaxel / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology; D013997:Time Factors
D054697:Cytostatic Agents; D017239:Paclitaxel