title: Transcriptional analysis of the Candida albicans cell cycle.
abstract: We have examined the periodic expression of genes through the cell cycle in cultures of the human pathogenic fungus Candida albicans synchronized by mating pheromone treatment. Close to 500 genes show increased expression during the G1, S, G2, or M transitions of the C. albicans cell cycle. Comparisons of these C. albicans periodic genes with those already found in the budding and fission yeasts and in human cells reveal that of 2200 groups of homologous genes, close to 600 show periodicity in at least one organism, but only 11 are periodic in all four species. Overall, the C. albicans regulatory circuit most closely resembles that of Saccharomyces cerevisiae but contains a simplified structure. Although the majority of the C. albicans periodically regulated genes have homologues in the budding yeast, 20% (100 genes), most of which peak during the G1/S or M/G1 transitions, are unique to the pathogenic yeast.
authors.affiliation: Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Québec H4P 2R2, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Côte
authors.forename: Hervé
authors.initials: H
authors.lastname: Hogues
authors.forename: Malcolm
authors.initials: M
authors.lastname: Whiteway
mesh_terms: D002176:Candida albicans / Q000166:cytology* / Q000235:genetics*; D002453:Cell Cycle / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics; D020869:Gene Expression Profiling; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D021122:Protein Subunits; D014157:Transcription Factors