title: Accelerated spectroscopic imaging of hyperpolarized C-13 pyruvate using SENSE parallel imaging.
abstract: The ability to accelerate the spatial encoding process during a chemical shift imaging (CSI) scan of hyperpolarized compounds is demonstrated through parallel imaging. A hardware setup designed to simultaneously acquire (13)C data from multiple receivers is presented here. A system consisting of four preamplifiers, four gain stages, a transmit coil, and a four receive channel rat coil was built for single channel excitation and simultaneous multi-channel detection of (13)C signals. The hardware setup was integrated with commercial scanner electronics, allowing the system to function similar to a conventional proton multi-channel setup, except at a different frequency. The ability to perform parallel imaging is demonstrated in vivo. CSI data from the accelerated scans are reconstructed using a self-calibrated multi-spectral parallel imaging algorithm, by using lower resolution coil sensitivity maps obtained from the central region of k-space. The advantages and disadvantages of parallel imaging in the context of imaging hyperpolarized compounds are discussed.
authors.affiliation: GE Global Research Center, Niskayuna, NY 12309, USA.
authors.forename: Arjun
authors.initials: A
authors.lastname: Arunachalam
authors.forename: David
authors.initials: D
authors.lastname: Whitt
authors.forename: Kenneth
authors.initials: K
authors.lastname: Fish
authors.forename: Randy
authors.initials: R
authors.lastname: Giaquinto
authors.forename: Joseph
authors.initials: J
authors.lastname: Piel
authors.forename: Ronald
authors.initials: R
authors.lastname: Watkins
authors.forename: Ileana
authors.initials: I
authors.lastname: Hancu
mesh_terms: D000465:Algorithms; D000818:Animals; D002250:Carbon Radioisotopes / Q000737:chemistry*; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D019289:Pyruvic Acid / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002250:Carbon Radioisotopes; D019289:Pyruvic Acid