title: Phosphorescence-Fluorescence ratio imaging for monitoring the oxygen status during photodynamic therapy.
abstract: The effectiveness of photodynamic therapy is strongly dependent on the availabilty of oxygen. In the present paper we show that the ratio between photosensitiser phosphorescence and fluorescence is a parameter that can be used to monitor the competition between singlet oxygen production and other processes quenching the photosensitiser triplet state. We present a theoretical basis for the validity of this approach and a series of in vitro imaging experiments.
authors.forename: H
authors.initials: H
authors.lastname: Sterenborg
authors.forename: J
authors.initials: J
authors.lastname: de Wolf
authors.forename: M
authors.initials: M
authors.lastname: Koning
authors.forename: B
authors.initials: B
authors.lastname: Kruijt
authors.forename: A
authors.initials: A
authors.lastname: van den Heuvel
authors.forename: D
authors.initials: D
authors.lastname: Robinson