title: Applicability of quantitative ultrasonography of the radius and tibia in HIV-infected children and adolescents.
abstract: OBJECTIVE
  To assess applicability of quantitative ultrasonography (QUS) for bone health assessment in HIV-infected youths.
  
  
  METHODS
  QUS measurements of the radius and tibia and dual-energy x-ray absorptiometry (DXA) measurements of the lumbar spine and whole skeleton were obtained in 88 HIV-infected children and adolescents (aged 4.8-22.1 years, 43 boys and 45 girls).
  
  
  RESULTS
  Radius speed of sound was significantly associated to lumbar spine and total body DXA measurements (R values from 0.57 to 0.60), after correction for differences in sex and anthropometry. Similarly, speed of sound of the tibia was associated to all DXA measurements (R from 0.58 to 0.66). The z scores calculated for lumbar spine DXA measurements were significantly lower (P < 0.0001) than those of QUS measurements, although no differences were observed between QUS and total body z scores.
  
  
  CONCLUSIONS
  Our study shows that QUS of the peripheral skeleton is related to DXA. The ability to detect low values is similar to that of total body DXA. Our data suggest that QUS may be an additional diagnostic tool for the study of bone mass in HIV-infected youths.
authors.affiliation: Laboratory of Pediatric Endocrinology, Pediatric Bone Densitometry Service and BoNetwork, San Raffaele Scientific Institute, Milan, Italy. mora.stefano@hsr.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Mora
authors.forename: Alessandra
authors.initials: A
authors.lastname: Viganò
authors.forename: Laura
authors.initials: L
authors.lastname: Cafarelli
authors.forename: Giulia
authors.initials: G
authors.lastname: Pattarino
authors.forename: Vania
authors.initials: V
authors.lastname: Giacomet
authors.forename: Clara
authors.initials: C
authors.lastname: Gabiano
authors.forename: Federica
authors.initials: F
authors.lastname: Mignone
authors.forename: Gianvincenzo
authors.initials: G
authors.lastname: Zuccotti
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D001823:Body Composition; D015519:Bone Density; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D010024:Osteoporosis / Q000150:complications / Q000000981:diagnostic imaging; D011884:Radius / Q000000981:diagnostic imaging*; D013977:Tibia / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D055815:Young Adult