title: Two cases of discontinuation syndrome following cessation of memantine.
abstract: Although memantine is widely used and generally considered safe, an abrupt cessation of memantine may result in discontinuation syndrome that can be distressing and result in decline of natural course. We report two patients who developed significant behavior disturbance after abrupt cessation of memantine. Although re-trial of memantine improves these symptoms, more additional drugs may be required to achieve previous status. Therefore, abrupt cessation of memantine should be prudent and require cautious follow up.
authors.affiliation: Department of Neurology, Yong-in Hyoja Geriatric Hospital, Yongin, Korea. ytkwak@drkwak.com
authors.forename: Yong Tae
authors.initials: YT
authors.lastname: Kwak
authors.forename: Il-Woo
authors.initials: IW
authors.lastname: Han
authors.forename: Seung-Han
authors.initials: SH
authors.lastname: Suk
authors.forename: Min-Seong
authors.initials: MS
authors.lastname: Koo
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008559:Memantine / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D008559:Memantine