Related mechanisms for mRNA and rRNA quality control.
In this issue of Molecular Cell, Cole et al. (2009) provide evidence that different defects in rRNA function are recognized by distinct RNA quality control systems, and suggest that a stalled ribosome can trigger either no-go decay of the mRNA or degradation of a nonfunctional 18S rRNA.
Swisher
Kylie D
KD
Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA.
Parker
Roy
R
D010442:Peptide Chain Initiation, Translational; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012335:RNA, Ribosomal / Q000235:genetics / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics
D012333:RNA, Messenger; D012335:RNA, Ribosomal