One-pot iodination of hydroxypyridines.
A one-pot, high-yielding iodination of hydroxypyridines and hydroxyquinolines is described. The iodination proceeds under mild conditions, and the products are obtained in high yield without the need for chromatographic purification. In addition, the iodination works on both 2- and 4-hydroxypyridines and -hydroxyquinolines.
Maloney
Kevin M
KM
Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. keVin_maloney@merck.com
Nwakpuda
Emily
E
Kuethe
Jeffrey T
JT
Yin
Jingjun
J
D002851:Chromatography, High Pressure Liquid; D054879:Halogenation; D006912:Hydroxyquinolines / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*
D006912:Hydroxyquinolines; D011725:Pyridines; C014047:hydroxypyridines