title: Secondary pathologic fractures in osteosarcoma: prognosis and evolution.
abstract: Secondary or pathologic fractures, associated with osteosarcoma, have been considered for a long time to be a negative prognosis regarding its evolution in the patients. The aim of this study was to evaluate the prognostic importance of such pathologic fractures in osteosarcoma patients receiving new therapies as well as the best conditions for surgery aiming at "limbs salvage". On a total of 22 patients affected by osteosarcoma, we performed a retrospective study with 12 patients showing pathologic fractures caused by osteosarcoma and 10 patients without any pathologic fracture. The patients enrolled into Timisoara University Hospital have been followed up along 5 years or until a reappearance of either the disease or metastases, distant or local.
authors.affiliation: University of Medicine and Pharmacy Victor Babes, Timisoara, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Vermesan
authors.forename: H
authors.initials: H
authors.lastname: Vermesan
authors.forename: S I
authors.initials: SI
authors.lastname: Dragulescu
authors.forename: I
authors.initials: I
authors.lastname: Bera
authors.forename: A
authors.initials: A
authors.lastname: Di Giovanni
authors.forename: R
authors.initials: R
authors.lastname: Sabatini
authors.forename: L
authors.initials: L
authors.lastname: Santacroce
authors.forename: L
authors.initials: L
authors.lastname: Bottalico
authors.forename: P
authors.initials: P
authors.lastname: Flace
authors.forename: R
authors.initials: R
authors.lastname: Cagiano
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000209:etiology* / Q000601:surgery; D006785:Hospitals, University; D006801:Humans; D023821:Limb Salvage / Q000379:methods*; D008297:Male; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000150:complications* / Q000188:drug therapy; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents