title: Three-dimensional bioluminescence tomography with model-based reconstruction.
abstract: A model-based image reconstruction method, bioluminescence tomography (BLT), is described. BLT has the potential to spatially resolve bioluminescence associated with gene expression in vivo, thus, offering a tomographic molecular imaging method. The three-dimensional spatial map of reporter genes is recovered using a diffusion equation model-based, finite element reconstruction algorithm. The imaging method is demonstrated using both numerical simulations and phantom experiments.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Gu
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Lyndon
authors.initials: L
authors.lastname: Larcom
authors.forename: Huabei
authors.initials: H
authors.lastname: Jiang