title: [Dyslexia: clinical, neurophysiological and neuropsychological manifestations during the treatment with nootropil].
abstract: Forty children with dyslexia, aged 7-12 years, have been randomized into two groups in an open controlled study: 18 of them received Nootropil (piracetam) in the dose of 100 mg/kg daily for 2 months and 22 were examined as a control group. Nootropil exerted positive effects on reading and spelling skills in 56% of children with dyslexia who demonstrated the improvement of fluency and accuracy of reading along with a significant decrease of specific errors (dysphonemic and visuospatial) in dictation. In the control group, the improvement was seen only in 10% of children. These data corresponded to the results of neuropsychological testing that demonstrated the improvement of automatic lexical retrieval, phonological skills and sustained attention in dyslexic children treated with nootropil as compared to the control group. The dynamics of interhemispheric asymmetry in EEG alpha-theta-subbands (4-13 Hz) during the performance of incomplete figures recognition test in the nootropil treatment may be indicative of the formation of compensative mechanisms linked with the functional activation of the right hemisphere structures and associative anterior left hemisphere areas which contributed to the progress in reading and spelling skills.
authors.forename: N N
authors.initials: NN
authors.lastname: Zavadenko
authors.forename: M V
authors.initials: MV
authors.lastname: Rumiantseva
authors.forename: V A
authors.initials: VA
authors.lastname: Tolstova
mesh_terms: D000513:Alpha Rhythm; D002648:Child; D004410:Dyslexia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D009424:Nervous System Physiological Phenomena; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010889:Piracetam / Q000008:administration & dosage / Q000627:therapeutic use*; D011932:Reading; D013826:Theta Rhythm; D013997:Time Factors; D016896:Treatment Outcome; D014956:Writing
chemical_list: D018697:Nootropic Agents; D010889:Piracetam