title: A single abnormal value of the glucose tolerance test is related to increased adverse perinatal outcome.
abstract: OBJECTIVE
  To evaluate which pregnant women with a single abnormal value in the oral glucose tolerance test are at increased risk for adverse perinatal outcome.
  
  
  METHODS
  In this retrospective cohort study, we have evaluated the course of pregnancy in 152 consecutive women with only one abnormal value (OAV), and 624 with a 100 g - glucose tolerance test totally within the range values.
  
  
  RESULTS
  The prevalence of caesarean delivery, hypertensive disorders and macrosomia was higher in the study group when compared with the control group, whereas no difference was noted concerning gestational age at delivery, Apgar score at 1 and 5 min and neonatal hypoglycemia. Moreover, in the study group hypertensive disorders were more frequent in the subgroup with the elevated value at 1 h after the glucose load (25%), whereas macrosomia is more frequent when it is the fasting value to be elevated (29.7%).
  
  
  CONCLUSIONS
  Our results show that the implications of a single elevated glucose tolerance test value vary in relation to the timing of the abnormal value. In fact, OAV fasting or 1-h after load has a higher prevalence for an adverse obstetric outcome, whereas a 2 or 3-h value does not present significant differences when compared with the control group.
authors.affiliation: Department of Obstetrics and Gynecology, University of Messina, Italy. francesco.corrado@unime.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Corrado
authors.forename: Antonino Di
authors.initials: AD
authors.lastname: Benedetto
authors.forename: Maria L
authors.initials: ML
authors.lastname: Cannata
authors.forename: Desiree
authors.initials: D
authors.lastname: Cannizzaro
authors.forename: Domenico
authors.initials: D
authors.lastname: Giordano
authors.forename: Giovanna
authors.initials: G
authors.lastname: Indorato
authors.forename: Piero
authors.initials: P
authors.lastname: Rizzo
authors.forename: Narcisio Carlo
authors.initials: NC
authors.lastname: Stella
authors.forename: Rosario
authors.initials: R
authors.lastname: D'Anna
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis* / Q000502:physiology; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data; D015331:Cohort Studies; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000453:epidemiology; D005951:Glucose Tolerance Test / Q000592:standards; D006801:Humans; D007003:Hypoglycemia / Q000151:congenital / Q000175:diagnosis; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D001786:Blood Glucose