Lobarialides A-C, antifungal triterpenoids from the lichen Lobaria kurokawae.
Three novel fernane-type triterpenoids, lobarialides A-C (1-3, resp.), together with two known ones were isolated by antifungal bioassay-guided fractionation of the lichen Lobaria kurokawae. Their structures including configurations were established on the basis of extensive spectroscopic analyses, and that of 1 was confirmed by a single-crystal X-ray diffraction analysis. Antifungal tests of the five triterpenoids showed that the activity increased with the increment of the number of COO groups.
Wang
Xiao-Ning
XN
Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan, P. R. China.
Zhang
Hai-Juan
HJ
Ren
Dong-Mei
DM
Ji
Mei
M
Yu
Wen-Tao
WT
Lou
Hong-Xiang
HX
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D008011:Lichens / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014961:X-Ray Diffraction
D000935:Antifungal Agents; D014315:Triterpenes; C542665:lobarialide A; C542666:lobarialide B; C542667:lobarialide C