title: Quality of life and adjuvant tamoxifen treatment in breast cancer patients.
abstract: About two-thirds of all breast cancer patients are treated with adjuvant hormonal therapy. Side effects of tamoxifen and their effects on physical, emotional and social functioning have been shown to impair the quality of life. Aim of this paper was to evaluate the side effects and level of influence on the physical, emotional and social functioning caused by tamoxifen treatment. For assessment of quality of life an own questionnaire was designed. Between January 2001 and December 2003, 136 women with breast cancer and adjuvant tamoxifen therapy were included in this study. Data of side effects, physical and mental health and patients' self-evaluation identified detrimental effects on patients' quality of life. Prevalence and severity of symptoms were not influenced by length of tamoxifen treatment. Patients were damaged in their constitution in respect to previous chemotherapy and pre-existing diseases; no influence was found by age or histopathological tumour characteristics. Our survey determines that breast cancer patients experience significant influence on quality of life by the negative impact on the physical, emotional and social functioning caused by tamoxifen treatment. Explicit attention to changes in quality of life should be considered as part of the standard care for women receiving adjuvant tamoxifen treatment.
authors.affiliation: Department of Obstetrics and Gynaecology, Johannes Gutenberg University, Mainz, Germany. dboehm@uni-mainz.de
authors.forename: Daniel Ulrich
authors.initials: DU
authors.lastname: Boehm
authors.forename: A
authors.initials: A
authors.lastname: Lebrecht
authors.forename: T
authors.initials: T
authors.lastname: Eckhardt
authors.forename: S
authors.initials: S
authors.lastname: Albrich
authors.forename: M
authors.initials: M
authors.lastname: Schmidt
authors.forename: W
authors.initials: W
authors.lastname: Siggelkow
authors.forename: E
authors.initials: E
authors.lastname: Kandelhardt
authors.forename: H
authors.initials: H
authors.lastname: Koelbl
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001828:Body Image; D001943:Breast Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen