title: A cross-sectional and longitudinal study of Fuchs uveitis syndrome in Turkish patients.
abstract: OBJECTIVE
  To describe Turkish patients with Fuchs uveitis syndrome (FUS).
  
  
  METHODS
  Retrospective observational case series.
  
  
  METHODS
  We reviewed the records of 172 patients with FUS seen at Istanbul University, Istanbul Faculty of Medicine, Department of Ophthalmology, between January 1995 and July 2007. The main outcome measures were demographic features, clinical findings at presentation, laser flare photometry values, risk of new complications, and rate of decreased vision.
  
  
  RESULTS
  The mean age was 29.5 + 8.4 years. Male-to-female ratio was 1:1.3. Nine patients (5.2%) had bilateral involvement. The diagnosis of FUS had been made in only 10 of 115 (8.7%) referrals. Clinical findings at presentation included diffuse keratic precipitates (medium-sized round in 74.6%, fine-stellate in 22.1%), anterior chamber cells (74%), diffuse iris atrophy without hypochromia (48.6%), heterochromia (39.8%), iris nodules (32%), cataract/pseudophakia (69.1%), vitreous cells (71.8%), elevated intraocular pressure (12.7%), and chorioretinal scars (7.7%). The mean flare was 8.4 + 3.1 photons/ms in eyes with FUS and 3.7 + 0.8 photons/ms in the fellow eyes (P < .001). Hyperfluorescence of the optic disc was the only fluorescein angiographic finding, detected in 7 of 32 eyes (22%). Kaplan-Meier analysis estimated risks of cataract formation and intraocular pressure elevation as 42% and 17%, respectively, at 4 years. The rate of decreased visual acuity by 2 lines or more was 0.06/eye-year.
  
  
  CONCLUSIONS
  The referral patterns suggest that FUS is frequently misdiagnosed in Turkish patients. Diffuse medium-sized round keratic precipitates, low flare readings, iris stromal atrophy without hypochromia, and vitreous opacities in the absence of macular edema are more often helpful clues to the diagnosis than heterochromia.
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul, Turkey. tutkun@tnn.net
authors.forename: Ilknur
authors.initials: I
authors.lastname: Tugal-Tutkun
authors.forename: Esra
authors.initials: E
authors.lastname: Güney-Tefekli
authors.forename: Fulya
authors.initials: F
authors.lastname: Kamaci-Duman
authors.forename: Isik
authors.initials: I
authors.lastname: Corum
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy; D002386:Cataract / Q000175:diagnosis; D002648:Child; D003316:Corneal Diseases / Q000175:diagnosis; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005901:Glaucoma / Q000175:diagnosis; D006801:Humans; D015863:Iridocyclitis / Q000175:diagnosis* / Q000453:epidemiology; D007498:Iris / Q000473:pathology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012017:Referral and Consultation; D012164:Retinal Diseases / Q000175:diagnosis; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult