title: Cardiopulmonary effects following endoscopic thoracic sympathectomy for primary hyperhidrosis.
abstract: BACKGROUND
  Endoscopic thoracic sympathectomy (ETS) is performed for the treatment of primary hyperhidrosis (PH). The second and third sympathetic thoracic ganglions excised in ETS also innervate the heart and lung.
  
  
  OBJECTIVE
  In the present work we studied the cardiopulmonary effects of ETS in a group of patients with PH.
  
  
  METHODS
  We performed a prospective study in 38 patients with severe PH. Pulmonary function, echocardiographic assessment of left ventricular function and myocardial contractility and maximal, symptom-limited, incremental exercise tests were evaluated 2 weeks before, and 6 months after ETS. Data were analysed with the paired t-test. Differences were considered significant when p<0.05.
  
  
  RESULTS
  In pulmonary function tests, we found a statistically significant decrease forced expiratory flow in small airways and an increase of residual volume, a significant decrease in heart rate and ejection fraction, a significant decrease of 'rest' and 'peak' heart rate, and a significant increase of oxygen pulse (O2 pulse) and oxygen peak uptake (VO2 peak) after ETS (p<0.05).
  
  
  CONCLUSIONS
  These cardiopulmonary effects observed 6 months after ETS in the treatment of patients with PH are all in normal ranges and are not relevant in cardiopulmonary function. We concluded that ETS in patients with PH is a safe procedure. Patients must be informed about these cardiopulmonary effects before the operation.
authors.affiliation: Serviço de Cirurgia Cardiotorácica, Hospital de Santa Maria, Lisboa, Portugal. costacruzjorge@gmail.com
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Cruz
authors.forename: Manuel
authors.initials: M
authors.lastname: Fonseca
authors.forename: Fausto J
authors.initials: FJ
authors.lastname: Pinto
authors.forename: Antonio G
authors.initials: AG
authors.lastname: Oliveira
authors.forename: L Silva
authors.initials: LS
authors.lastname: Carvalho
mesh_terms: D000293:Adolescent; D015150:Echocardiography, Doppler / Q000379:methods; D005080:Exercise Test / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006945:Hyperhidrosis / Q000601:surgery*; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D011184:Postoperative Period; D011446:Prospective Studies; D012129:Respiratory Function Tests / Q000379:methods; D013562:Sympathectomy / Q000009:adverse effects / Q000379:methods*; D020775:Thoracic Surgery, Video-Assisted / Q000009:adverse effects / Q000379:methods*; D016277:Ventricular Function, Left / Q000502:physiology; D055815:Young Adult