Multipotent mesenchymal stromal cells of autologous bone marrow stimulate neoangiogenesis, restore microcirculation, and promote healing of indolent ulcers of the stomach.
The effects of precultured multipotent mesenchymal stromal cells from autologous bone marrow on microcirculation and regeneration of experimental indolent stomach ulcer were studied in experiments on rats. It was demonstrated that precultured multipotent mesenchymal stromal bone marrow cells delivered to the zone of chronic gastric ulcer stimulate neoangiogemesis, improve microcirculation in the gastric mucosa, and promote ulcer healing.
Askarov
M B
MB
Institute of Transplantology and Artificial Organs, Moscow. illak@mail.ru
Onischenko
N A
NA
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology*; D064987:Cell- and Tissue-Based Therapy; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D008833:Microcirculation / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000628:therapy*; D017154:Stromal Cells / Q000166:cytology / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*