With Happyhour, everyone's under the table.
The molecular and cellular targets that mediate alcohol intoxication are poorly understood. In this issue, Corl et al. (2009) now implicate a new Ste20 family kinase (Happyhour) and the EGFR/ERK signaling pathway it antagonizes in alcohol intoxication in flies.
Palfreyman
Mark T
MT
Research Institute of Molecular Pathology, A-1030 Vienna, Austria. markthomas.palfreyman@imp.ac.at
D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D020935:MAP Kinase Signaling System; D009154:Mutation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
D029721:Drosophila Proteins; D066246:ErbB Receptors; D017346:Protein Serine-Threonine Kinases; C541347:hppy protein, Drosophila; D048049:Extracellular Signal-Regulated MAP Kinases