title: Air pollution and antibodies against modified lipoproteins are associated with atherosclerosis and vascular remodeling in hyperlipemic mice.
abstract: We analyzed the impact of chronic exposure to urban air pollution on the development of atherosclerosis. Hyperlipemic mice (LDLR(-/-)) were submitted to a high fat diet and air pollution for four months. We measured the susceptibility of LDL to oxidative modifications (TBARS), the presence of anti-oxLDL and an apoB-derived peptide (apoB-D) in blood and the degree of atherosclerosis in the aortic arch. Air pollution increased the susceptibility of LDL to oxidation as well as anti-oxLDL and anti-apo-B levels. These levels were even higher than in mice submitted to a high fat diet and non-polluted air. The lipid content of the atherosclerotic plaques in the aorta was increased in groups with a high cholesterol diet independently of the air quality. However, the thickness of the arterial wall was greater in mice fed a high lipid diet with polluted air. Thus, we conclude that urban air pollution exacerbates the susceptibility of LDL to oxidation, atherogenesis and vascular remodeling in hyperlipemic mice and that an immune response accompanies this process.
authors.affiliation: Laboratory of Soropidemiology and Immunobiology Laboratory, School of Medicine, University of São Paulo, Brazil.
authors.forename: Sandra Regina Castro
authors.initials: SR
authors.lastname: Soares
authors.forename: Regiani
authors.initials: R
authors.lastname: Carvalho-Oliveira
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ramos-Sanchez
authors.forename: Sergio
authors.initials: S
authors.lastname: Catanozi
authors.forename: Luiz Fernando Ferreira
authors.initials: LF
authors.lastname: da Silva
authors.forename: Thaís
authors.initials: T
authors.lastname: Mauad
authors.forename: Magnus
authors.initials: M
authors.lastname: Gidlund
authors.forename: Hiro
authors.initials: H
authors.lastname: Goto
authors.forename: Maria Lúcia Bueno
authors.initials: ML
authors.lastname: Garcia
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D000906:Antibodies / Q000097:blood*; D001011:Aorta / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D001018:Aortic Diseases / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D001055:Apolipoproteins B / Q000276:immunology*; D050197:Atherosclerosis / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D001273:Atmosphere Exposure Chambers; D049109:Cell Proliferation; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000150:complications* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D019570:Inhalation Exposure; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011973:Receptors, LDL / Q000172:deficiency / Q000235:genetics; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D000906:Antibodies; D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; C099252:oxidized low density lipoprotein