Simultaneous measurement of 23 plasma cytokines in late-life depression.
According to the cytokine hypothesis of depression, cytokines play key roles in the behavioral, neuroendocrinal, and neurochemical features of depression. In this study, we used a bioplex assay to simultaneously measure the levels of 23 plasma cytokines in 18 patients with late-life depression and 38 normal controls, and these levels were compared between the two groups. The plasma interleukin-1alpha (IL-1alpha) levels were found to be significantly different between the two groups. After adjusting for age, gender, low-density lipoprotein cholesterol, and triglyceride, the plasma IL-1alpha levels were significantly higher in the patients with late-life depression than in the normal control subjects. Thus, this study provides preliminary evidence that plasma IL-1alpha may play important roles in the pathogenesis of late-life depression.
Lee
Kang Soo
KS
Department of Psychiatry, Pochon CHA University College of Medicine, Seongnam, Korea.
Chung
Ji Hyung
JH
Lee
Kyung Hye
KH
Shin
Min-Jeong
MJ
Oh
Byoung Hoon
BH
Lee
Soo Hyung
SH
Hong
Chang Hyung
CH
D000368:Aged; D000369:Aged, 80 and over; D016207:Cytokines / Q000097:blood*; D003863:Depression / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000378:metabolism*
D016207:Cytokines