Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases.
The anticholinesterase activities of newly synthesized phosphorothioates and phosphorodithioates were investigated. The compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition potency through IC(50) determination. The selectivities of the synthesized compounds toward both enzymes were determined and compared in terms of their molecular structures.
Kaboudin
Babak
B
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan, Iran. kaboudin@iasbs.ac.ir
Emadi
Saeed
S
Hadizadeh
Atefeh
A
D000110:Acetylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology; D009946:Organothiophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010710:Phosphates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009946:Organothiophosphorus Compounds; D010710:Phosphates; C083120:phosphorodithioic acid; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase