title: A new dibenzofuran and further constituents from the stems of Pourthiaea lucida with inhibitory activity on superoxide generation by neutrophils.
abstract: A new dibenzofuran, lucidafuran (1), was isolated from the stems of Pourthiaea lucida, together with eight known compounds. The structure of this new compound was determined through NMR and mass-spectrometric analyses. Among the isolated compounds, lucidafuran (1) and aucuparin (3) exhibited potent inhibitory activity against fMLP-induced superoxide (O(*-)(2)) production by human neutrophils with IC(50) values of 18.7+/-4.4 and 17.0+/-6.8 microM, resp.
authors.affiliation: Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Luo
authors.forename: Chang-Hui
authors.initials: CH
authors.lastname: Liao
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Chih-Chuang
authors.initials: CC
authors.lastname: Liaw
mesh_terms: D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D018547:Plant Stems / Q000737:chemistry; D027824:Rosaceae / Q000737:chemistry*; D013481:Superoxides / Q000378:metabolism*
chemical_list: C542669:4-methoxydibenzo(b,d)furan-2,3-diol; D001572:Benzofurans; D016166:Free Radical Scavengers; D013481:Superoxides; C023614:dibenzofuran