title: Cutaneous large B-cell lymphoma of the leg: presenting initially as mononeuritis multiplex.
abstract: We report a rare case of primary B-cell lymphoma of the leg presenting with mononeuropathy multiplex. A 79-year-old Chinese woman who was being investigated for mononeuritis multiplex had an incidental finding of indurated erythematous plaques on the breast and left leg. A skin biopsy from the nodular area on the right breast showed a dense and diffuse infiltrate of atypical cells with large, round, hyperchromatic nuclei with prominent nucleoli. These atypical lymphocytes were CD20+, Bcl-2+ and Mum-1+. A diagnosis of diffuse large B-cell lymphoma, leg type involving the breast and leg with extracutaneous involvement, was made. This case highlights the importance of a full systemic and cutaneous examination in patients presenting with progressive, painful peripheral neuropathy.
authors.affiliation: National Skin Centre, 1 Mandalay Road, Singapore. sheunling@yahoo.com
authors.forename: S L
authors.initials: SL
authors.lastname: Ho
authors.forename: B Y
authors.initials: BY
authors.lastname: Tang
authors.forename: J
authors.initials: J
authors.lastname: Chai
authors.forename: S H
authors.initials: SH
authors.lastname: Tan
mesh_terms: D000368:Aged; D018951:Antigens, CD20; D001943:Breast Neoplasms / Q000175:diagnosis / Q000276:immunology; D005260:Female; D006801:Humans; D050835:Interferon Regulatory Factors; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000276:immunology; D020422:Mononeuropathies / Q000175:diagnosis*; D019253:Proto-Oncogene Proteins c-bcl-2; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000276:immunology; D000099218:Interferon Regulatory Factor-4
chemical_list: D018951:Antigens, CD20; D050835:Interferon Regulatory Factors; D019253:Proto-Oncogene Proteins c-bcl-2; D000099218:Interferon Regulatory Factor-4