title: Gastroparesis, pseudoachalasia and impaired intestinal motility as paraneoplastic manifestations of small cell lung cancer.
abstract: Lung cancer is the worldwide leading cause of cancer deaths. Small cell lung cancer (SCLC) represents about 15% of lung cancers with a poor 5-year survival rate. SCLC can manifest as a paraneoplastic syndrome, which can include unexplained gastrointestinal dysmotility symptoms. The awareness of these presenting symptoms and recognition that serum markers, such as anti-Hu antibodies, mediate the paraneoplastic neuromuscular aspects of SCLC are highlighted in this case report of a patient with anti-Hu antibodies presenting with gastroparesis, pseudoachalasia, and impaired intestinal motility.
authors.affiliation: Department of Medicine, Kansas University Medical Center, Kansas City, Kansas, USA.
authors.forename: Reza A
authors.initials: RA
authors.lastname: Hejazi
authors.forename: Da
authors.initials: D
authors.lastname: Zhang
authors.forename: Richard W
authors.initials: RW
authors.lastname: McCallum
mesh_terms: D051959:ELAV Proteins / Q000378:metabolism; D004931:Esophageal Achalasia / Q000209:etiology*; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000503:physiopathology; D005769:Gastrointestinal Motility; D018589:Gastroparesis / Q000209:etiology*; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology; D008207:Lymphatic Metastasis; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology; D055752:Small Cell Lung Carcinoma / Q000150:complications* / Q000473:pathology
chemical_list: D051959:ELAV Proteins