title: Sustained elevation in intraocular pressure associated with intravitreal bevacizumab injections.
abstract: This retrospective case series reports sustained elevation of intraocular pressure (IOP) after single or repeated intravitreal injections of bevacizumab (Avastin; Genentech, San Francisco, CA) for wet age-related macular degeneration (AMD). All six cases experienced significant and sustained elevation in IOP after single or repeated intravitreal injections of bevacizumab. Initiation or advancement of IOP-lowering therapy was required in all cases. The results support the need for further studies investigating the incidence of this potential side effect and the need for close long-term surveillance of IOP after injection of bevacizumab, particularly in patients with glaucoma or suspected glaucoma. Future in vitro and in vivo studies are needed to better understand the reasons for this observed phenomenon.
authors.affiliation: Department of Ophthalmology, Rocky Mountain Lions Eye Institute, University of Colorado at Denver, Aurora 80045, USA.
authors.forename: Malik Y
authors.initials: MY
authors.lastname: Kahook
authors.forename: Alan E
authors.initials: AE
authors.lastname: Kimura
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Wong
authors.forename: David A
authors.initials: DA
authors.lastname: Ammar
authors.forename: Marco A
authors.initials: MA
authors.lastname: Maycotte
authors.forename: Naresh
authors.initials: N
authors.lastname: Mandava
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized; D000959:Antihypertensive Agents / Q000627:therapeutic use; D000068258:Bevacizumab; D020256:Choroidal Neovascularization / Q000188:drug therapy; D005260:Female; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects*; D008268:Macular Degeneration / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000139:chemically induced* / Q000188:drug therapy; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014822:Vitreous Body
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000959:Antihypertensive Agents; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab