title: The dominance of China 1 in the spectrum of Epstein-Barr virus strains from Cantonese patients with nasopharyngeal carcinoma.
abstract: Nasopharyngeal carcinoma is a disease with a remarkable geographic and ethnic distribution, and has a high incidence in southern China. Infection with Epstein-Barr virus (EBV) is an important contributing factor. The profile of EBV strains in Cantonese patients from Guangdong, the nasopharyngeal carcinoma endemic region in southern China, is described on the sequence variations in latent membrane protein 1 carboxyl-terminus. The results show that China 1 was the dominant EBV strain detected in both the tumor biopsies and samples of throat washings, whereas multiple strains, including China 1, China 2, B95-8, and Med, were detected in blood samples. In addition, a new strain named China 4 was found in blood samples. These findings suggest that the host population is susceptible to the predominant China 1 strain in the nasopharyngeal carcinoma endemic region of China, but its relationship with the host remains to be characterized further.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Guangzhou, China.
authors.forename: Da-Jiang
authors.initials: DJ
authors.lastname: Li
authors.forename: Jin-Xin
authors.initials: JX
authors.lastname: Bei
authors.forename: Shi-Juan
authors.initials: SJ
authors.lastname: Mai
authors.forename: Jin-Fen
authors.initials: JF
authors.lastname: Xu
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Chen
authors.forename: Ru-Hua
authors.initials: RH
authors.lastname: Zhang
authors.forename: Xing-Juan
authors.initials: XJ
authors.lastname: Yu
authors.forename: Ming-Huang
authors.initials: MH
authors.lastname: Hong
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Zeng
authors.forename: Tiebang
authors.initials: T
authors.lastname: Kang
mesh_terms: D001769:Blood / Q000821:virology; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D019353:Endemic Diseases; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000821:virology*; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000821:virology*; D010614:Pharynx / Q000821:virology; D017422:Sequence Analysis, DNA; D014763:Viral Matrix Proteins / Q000235:genetics
chemical_list: D004279:DNA, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins