Do melanoidins induced by topical 9% dihydroxyacetone sunless tanning spray inhibit vitamin d production? A pilot study.
We report here preliminary pilot study data of the effect of sunless tanning spray with 9% [Correction added after online publication (August 24th, 2009): The concentration of Dihydroxyacetone used in the study was 9% and not 3% as previously stated] dihydroxyacetone (DHA) on 25-hydroxyvitamin D [25(OH)D] serum levels in subjects exposed to controlled amounts of UV-B radiation during April/May in Omaha, NE, 41 degrees N latitude. We found that DHA-induced melanoidins in skin act as a topical sunscreen attenuating the formation of 25(OH)D.
Armas
Laura A G
LA
Osteoporosis Research Center, Creighton University, Omaha, NE, USA. larmas@creighton.edu
Fusaro
Ramon M
RM
Sayre
Robert M
RM
Huerter
Christopher J
CJ
Heaney
Robert P
RP
D000287:Administration, Topical; D004098:Dihydroxyacetone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D010865:Pilot Projects; D011108:Polymers / Q000008:administration & dosage*; D014807:Vitamin D / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
D011108:Polymers; C011908:melanoidin polymers; D014807:Vitamin D; D004098:Dihydroxyacetone