A new dimeric phenylpropanoid and cytotoxic norditerpene constituents from Podocarpus nakaii.
A new dimeric phenylpropanoid namely podonaka A (1), along with the 13 known compounds including diterpenes (2 and 3), norditerpenes (4 and 5), benzenoids (6-10), steroids (11 and 12), chalcone (13), and megastigmane (14), was isolated from the EtOH extract of Podocarpus nakaii Hayata. The structure of 1 was elucidated on the basis of spectroscopic analysis including 1D and 2D NMR and MS techniques. Biological evaluation showed that norditerpenes, inumakilactone B (4), and podolactone E (5) have potent cytotoxic activities against Daoy, WiDr, KB, and HeLa tumor cell lines. Moreover, low dosage of 5 may induce early apoptosis in KB cells before 12 h.
Huang
Syh-Yuan
SY
Department of Agriculture and Forestry, Taiwan Endemic Species Research Institute, Nantou County, Taiwan.
Fan
Long-Yun
LY
Shen
Ya-Ching
YC
Liao
Chia-Ching
CC
Hsu
Li-Chuan
LC
Hsu
Ya-Wen
YW
Wu
Tian-Shan
TS
Hsiao
Ping-Chun
PC
Shen
Chien-Chang
CC
Don
Ming-Jaw
MJ
Kuo
Yao-Haur
YH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan; D064028:Tracheophyta / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010666:Phenylpropionates; C541243:podonaka A