title: Comparison of the quality of life of early and advanced stage ovarian cancer survivors.
abstract: OBJECTIVE
  The objective of this study was to compare the long-term adjustment and QOL of early and advanced stage ovarian cancer survivors (OCS).
  
  
  METHODS
  Early and advanced OCS >3 years from diagnosis with no evidence of recurrent cancer were interviewed. The following surveys were administered: EORTC QLQ-C30 (overall QOL) and QLQ-OV28 (ovarian specific issues), MHI-17 (anxiety, depression and global well-being), CALGB sexual functioning, FACT Fatigue, Beck's Hopelessness Scale, Fear of Recurrence (FOR), PCL-C post-traumatic stress disorder (PTSD), Unmet Needs, FACT-Spirituality (FACT-Sp), complementary therapy (CAM use), and MOS Social Support Survey (MOS). The results of the surveys were compared between the early and advanced stage groups.
  
  
  RESULTS
  42 advanced and 58 early stage patients were interviewed. The majority of survivors scored above the medical outpatient norm for emotional status (71% of early stage and 64% of advanced stage survivors). Overall QOL, fatigue, hopelessness, spirituality, social support, degree to which unmet needs were met and use of complementary therapy, did not differ between the two groups. No advanced stage OCS had diagnosable PTSD scores, while 6.9% of early stage survivors had scores indicative of PTSD. Decreased sexual interest attributed to cancer and anxiety when getting CA-125 testing were of concern for both groups. OCS used on average 5 CAM to improve their QOL.
  
  
  CONCLUSIONS
  Regardless of staging, OCS experience similarly overall positive QOL and adjustment, though PTSD, sexual problems and fear of recurrence are still important for some survivors.
authors.affiliation: Harvard Medical School, Boston, MA, USA. Klm17@hms.harvard.edu
authors.forename: Kristina L
authors.initials: KL
authors.lastname: Mirabeau-Beale
authors.forename: Alice B
authors.initials: AB
authors.lastname: Kornblith
authors.forename: Richard T
authors.initials: RT
authors.lastname: Penson
authors.forename: Hang
authors.initials: H
authors.lastname: Lee
authors.forename: Annekathryn
authors.initials: A
authors.lastname: Goodman
authors.forename: Susana M
authors.initials: SM
authors.lastname: Campos
authors.forename: Linda
authors.initials: L
authors.lastname: Duska
authors.forename: Lauren
authors.initials: L
authors.lastname: Pereira
authors.forename: Jessica
authors.initials: J
authors.lastname: Bryan
authors.forename: Ursula A
authors.initials: UA
authors.lastname: Matulonis
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000523:psychology; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology*; D011788:Quality of Life; D012959:Socioeconomic Factors; D017741:Survivors