Invasive pulmonary fungal infection accompanied by severe hemoptysis in patients with hematologic diseases: a report of nine cases.
Severe hemoptysis is the fatal complication of invasive pulmonary fungal infection (IPFI) in patients with hematologic diseases. This report retrospectively analyzed the clinical data of nine IPFI patients with hematologic diseases complicated with severe hemoptysis. Four in nine patients were diagnosed of proven IPFI, probable was established in two and the remaining were diagnosed of possible. Seven patients did not respond to the primary treatment, and four of them also did not respond to the salvage therapy. In these nine patients, seven presented massive hemoptysis and all died of that; other two patients presented severe hemoptysis. The result indicates that ineffective initial treatment and irregular therapy may underlie the concurrence of massive hemoptysis. The prognosis of IPFI patients with massive hemoptysis is very poor. Special attention for IPFI treatment should be prophylaxis, early management as well as sufficient and a whole course administration of effective broad-spectrum antifungal agents.
Qiu
Lei
L
Department of Hematology, People's Hospital of Zhoushan, 238 North Renmin Road, Dinghai, Zhoushan, Zhejiang, People's Republic of China.
He
Jingsong
J
Department of Hematology and Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China. hjs2005@263.net.
Ye
Xiujin
X
Department of Hematology and Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Xie
Wanzhuo
W
Department of Hematology and Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Shi
Jimin
J
Department of Hematology and Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Zheng
Weiyan
W
Department of Hematology and Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Sun
Jie
J
Department of Hematology and Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Zhu
Xiaoli
X
Department of Hematology and Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Cai
Zhen
Z
Department of Hematology and Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Huang
He
H
Department of Hematology and Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Lin
Maofang
M
Department of Hematology and Bone Marrow Transplantation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
D000293:Adolescent; D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006402:Hematologic Diseases / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006469:Hemoptysis / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies