title: Chemokines and angiogenesis in rheumatoid arthritis.
abstract: In rheumatoid arthritis, chemokines mediate the migration of inflammatory leukocytes into the synovium. Among the four known chemokine families, CXC, CC chemokines and fractalkine seem to be of outstanding importance in this process. Angiogenesis, the formation of new vessels, is also important during the perpetuation of inflammation underlying rheumatoid arthritis. In this review, authors discuss the role of the most important chemokines and chemokine receptors in arthritis-associated neovascularization. The process and regulation of angiogenesis are described in this context as well. Apart from discussing the pathogenic role of chemokines and chemokine receptors in arthritic vessel formation, authors also review the important relevance of chemokines and angiogenesis for therapeutic intervention.
authors.affiliation: Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H-4004, Hungary. szekanecz@iiibel.dote.hu
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Szekanecz
authors.forename: Angela
authors.initials: A
authors.lastname: Pakozdi
authors.forename: Agnes
authors.initials: A
authors.lastname: Szentpetery
authors.forename: Timea
authors.initials: T
authors.lastname: Besenyei
authors.forename: Alisa E
authors.initials: AE
authors.lastname: Koch
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000503:physiopathology; D018925:Chemokines / Q000276:immunology*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000276:immunology*; D019707:Receptors, Chemokine / Q000276:immunology*; D013583:Synovial Membrane / Q000276:immunology / Q000473:pathology*
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine