title: Chorangiosis and placental oxygenation.
abstract: Chorangiosis is a vascular hyperplasia in the terminal chorionic villi, usually diagnosed histologically using the criteria of Altshuler. Its true etiology has not been fully identified, but chorangiosis has been proposed to result from a longstanding, rather low-grade hypoxia in the placental tissue. To clarify a possible association of placental oxygenation status with the development of chorangiosis, we measured placental tissue oxygen index (TOI) values using near-infrared spectroscopy (NIRS) before delivery and retrospectively compared them to the detection of placental chorangiosis, in a total of 47 (46 singleton and one set of dichorionic diamniotic twins) pregnant women. Small for gestational age (SGA) and/or maternal complications were observed in all cases of placental chorangiosis. Placental TOI values were significantly elevated in cases of chorangiosis. This indicates high oxygen saturation in the intervillous spaces because placental TOI values are expected to represent the oxygenation of maternal blood in the placental tissue. A possible preceding low efficiency of oxygen transfer to the fetal circulation in the villi might not only augment the oxygen saturation of maternal blood in intervillous spaces, but also cause rather low oxygenation in the capillaries of the villi and result in chorangiosis.
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: Kazunao
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Itoh
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kimura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sugihara
authors.forename: Chizuko
authors.initials: C
authors.lastname: Yaguchi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Kyuya
authors.initials: K
authors.lastname: Hirai
authors.forename: Kinya
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Motoi
authors.initials: M
authors.lastname: Sugimura
authors.forename: Naohiro
authors.initials: N
authors.lastname: Kanayama
mesh_terms: D000328:Adult; D002824:Chorionic Villi / Q000098:blood supply* / Q000473:pathology; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D010922:Placenta Diseases / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000473:pathology; D019265:Spectroscopy, Near-Infrared; D014429:Twins, Dizygotic; D055815:Young Adult
chemical_list: D010100:Oxygen