Hormonal signaling to follicle stimulating hormone beta-subunit gene expression.
Expression of the hormone-specific beta-subunit of follicle stimulating hormone (FSHbeta) is regulated primarily by gonadotropin releasing hormone (GnRH) and activin, with additional feedback by various steroids. While the nature of this hormonal regulation appears conserved, the molecular mechanisms mediating these effects appear less so. This is apparent from the diverse cis-elements required for hormonal stimulation in different species, distinct transcription factors that seem to mediate the effects, as well as the lack of conservation of several reportedly functional cis-elements across species. Recent additional information on the molecular mechanisms through which these regulatory hormones exert their effects, supports the possibility of species-specific mechanisms of regulation, while some redundancy may exist in signaling by the activated transcription factors which allows preservation of the hormonal regulation in these different promoter contexts.
Melamed
Philippa
P
Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel. philippa@tx.technion.ac.il
D028341:Activins / Q000378:metabolism*; D000818:Animals; D037201:Follicle Stimulating Hormone, beta Subunit / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006801:Humans; D012098:Reproduction / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
D037201:Follicle Stimulating Hormone, beta Subunit; D028341:Activins; D007987:Gonadotropin-Releasing Hormone