title: Highly diastereo- and enantioselective Pd-catalyzed cyclopropanation of acyclic amides with substituted allyl carbonates.
abstract: A highly diastereo- and enantioselective cyclopropanation reaction was realized in the reaction of acyclic amides with monosubstituted allyl carbonates via Pd-catalysis using a ferrocene ligand with H as a substituent on an oxazoline ring, providing cyclopropane products having three chiral centers in yields of 67-83%, the dr ratio being 4-23:1, and ee being 83-97%. The presence of LiCl is important for the gain of high diastereo- and enantioselectivities of the reaction.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, 200032, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Di
authors.initials: D
authors.lastname: Chen
authors.forename: Xia-Zhen
authors.initials: XZ
authors.lastname: Zhu
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Wan
authors.forename: Xue-Long
authors.initials: XL
authors.lastname: Hou