title: Osteosarcoma in a pregnant patient with McCune-Albright syndrome.
abstract: Malignant transformation of fibrous dysplasia is very rare and has not been previously described in patients with McCune-Albright syndrome in the absence of radiation treatment during gestation. Here, we report a 38-year-old pregnant woman with McCune-Albright syndrome and acromegaly accompanied by osteosarcoma. The patient was in the 6th week of pregnancy, when she visited our hospital. She had multiple fibrous dysplasia, skin pigmentation, and acromegaly. The markedly high bone turnover rate during pregnancy tended to decrease after a normal delivery. Fibrous dysplasia of the lower jaw rapidly increased in the 37th week of pregnancy, and the tumor was surgically resected after delivery. Pathological examination of the resected tumor revealed fibrous dysplasia admixed with osteosarcoma containing chondroblastic and osteoblastic tissue. We firstly reported a case of osteosarcoma in a patient with McCune-Albright syndrome, which rapidly progressed during pregnancy.
authors.affiliation: Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo 693-8501, Japan. ippei.k@med.shimane-u.ac.jp
authors.forename: Ippei
authors.initials: I
authors.lastname: Kanazawa
authors.forename: Mika
authors.initials: M
authors.lastname: Yamauchi
authors.forename: Shozo
authors.initials: S
authors.lastname: Yano
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Imanishi
authors.forename: Riko
authors.initials: R
authors.lastname: Kitazawa
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nariai
authors.forename: Asuka
authors.initials: A
authors.lastname: Araki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inaba
authors.forename: Riruke
authors.initials: R
authors.lastname: Maruyama
authors.forename: Toru
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D000172:Acromegaly / Q000150:complications*; D000328:Adult; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications*; D006801:Humans; D007573:Jaw Neoplasms / Q000150:complications*; D012516:Osteosarcoma / Q000150:complications*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic