title: Structural and functional changes over time in MacTel patients.
abstract: OBJECTIVE
  To investigate functional and morphologic alterations over a 1-year review analysis in patients with type 2 idiopathic juxtafoveal retinal telangiectasia (MacTel).
  
  
  METHODS
  Nine eyes of 9 patients with MacTel underwent repeated scotopic and photopic fine matrix mapping (FMM), 10-2 photopic microperimetry, and imaging studies.
  
  
  RESULTS
  Early Treatment Diabetic Retinopathy Study visual acuity assessment showed a median difference between examinations of 1.0 letter (range, -3 to 4 letters). The difference of sensitivity values of all test points was 4.5 dB (range, 0.4 -5.5 dB) for microperimetry 1, 0.4 dB (range, -0.8 to 1.7 dB) for photopic, and -1.7 dB (range, -6.1 to 1.0 dB) for scotopic fine matrix mapping, respectively. The difference in test points of more than a 10-dB loss compared with age-matched controls was higher for scotopic than for photopic testing (P= 0.03, Wilcoxon signed ranks test). Small progression of scotoma correlated with a slight increase in retinal blood vessel dilatation and hyperfluorescence and subtle enlargement of pigmented plaques.
  
  
  CONCLUSIONS
  Changes in central visual acuity and microperimetry testing after 1 year most likely do not extend beyond test-retest variability. The deterioration of scotopic sensitivity confirms our previous results of more severe rod compared with cone dysfunction in MacTel. Changes in fine detail visual function over a 1-year period may be useful parameters for interventional trials.
authors.affiliation: Institute of Ophthalmology, University College London, UK.
authors.forename: Steffen
authors.initials: S
authors.lastname: Schmitz-Valckenberg
authors.forename: E E Lin
authors.initials: EE
authors.lastname: Ong
authors.forename: Gary S
authors.initials: GS
authors.lastname: Rubin
authors.forename: Tunde
authors.initials: T
authors.lastname: Peto
authors.forename: Adnan
authors.initials: A
authors.lastname: Tufail
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Egan
authors.forename: Alan C
authors.initials: AC
authors.lastname: Bird
authors.forename: Fred W
authors.initials: FW
authors.lastname: Fitzke
mesh_terms: D000328:Adult; D000368:Aged; D005451:Fluorescein Angiography; D006801:Humans; D008875:Middle Aged; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology*; D011446:Prospective Studies; D012164:Retinal Diseases / Q000503:physiopathology*; D012171:Retinal Vessels / Q000473:pathology*; D012607:Scotoma / Q000503:physiopathology; D013684:Telangiectasis / Q000503:physiopathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology