title: Eastern equine encephalitis virus infection and hemophagocytic lymphohistiocytosis in a 5-month-old infant.
abstract: Eastern equine encephalitis virus infection is a rare sporadic central nervous system infection transmitted by a mosquito vector. Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease associated with the inability of an overactive immune system to effectively respond to infections. Many viruses are known to trigger primary, as well as secondary, HLH. We report a pediatric case of eastern equine encephalitis virus-associated HLH which caused severe neurologic injury and death.
authors.affiliation: Department of Pediatrics, University of South Alabama College of Medicine, Mobile, AL, USA. mmancao@usouthal.edu
authors.forename: Mary Y
authors.initials: MY
authors.lastname: Mancao
authors.forename: Hamayun
authors.initials: H
authors.lastname: Imran
authors.forename: Sharat
authors.initials: S
authors.lastname: Chandra
authors.forename: Benjamin
authors.initials: B
authors.lastname: Estrada
authors.forename: Maria
authors.initials: M
authors.lastname: Figarola
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Sosnowski
authors.forename: Rosa
authors.initials: R
authors.lastname: Vidal
mesh_terms: D004663:Encephalitis Virus, Eastern Equine / Q000302:isolation & purification; D020242:Encephalomyelitis, Eastern Equine / Q000150:complications / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D017809:Fatal Outcome; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male
chemical_list: D007166:Immunosuppressive Agents