title: [Time domain OCT versus frequency domain OCT: measuring differences of macular thickness in healthy subjects].
abstract: BACKGROUND
  When changing from previously used time domain OCTs (TD-OCT) to frequency domain OCTs (FD-OCT) the question arises how to evaluate the progress of macular disease.
  
  
  METHODS
  OCT examinations and calculation (mapping) of the central retinal thickness were carried out in 40 healthy eyes with the Stratus OCT (Carl Zeiss Meditec Inc.; TD-OCT) as well as the Spectralis-OCT (Heidelberg Engineering GmbH 2008; FD-OCT).
  
  
  RESULTS
  The average central macular thickness was 218 microm in the Stratus OCT and 282 microm in the Spectralis-OCT. The average difference was 69 microm (p < 0.001). The mean value of single measurements showed a macular thickness of 195 microm when performed with the Stratus OCT and of 235 microm with the Spectralis-OCT. The difference of 40 microm was statistically significant (p < 0.001).
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, Universität Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Deutschland. chaber@eye-regensburg.de
authors.forename: S
authors.initials: S
authors.lastname: Chaber
authors.forename: H
authors.initials: H
authors.lastname: Helbig
authors.forename: Ma
authors.initials: M
authors.lastname: Gamulescu
mesh_terms: D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008266:Macula Lutea / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*