Ultrasound-mediated oxygen delivery from chitosan nanobubbles.
Ultrasound (US) energy combined with gas-filled microbubbles has been used for several years in medical imaging. This study investigated the ability of oxygen-loaded chitosan bubbles to exchange oxygen in the presence or in the absence of US. Oxygen delivery is enhanced by sonication and both frequency and time duration of US affected the exchange kinetics.
Cavalli
Roberta
R
Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, 10125 Torino, Italy. roberta.cavalli@unito.it
Bisazza
Agnese
A
Rolfo
Alessandro
A
Balbis
Sonia
S
Madonnaripa
Daniele
D
Caniggia
Isabella
I
Guiot
Caterina
C
D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D045423:Microbubbles; D010100:Oxygen / Q000008:administration & dosage*; D013010:Sonication / Q000379:methods*; D013997:Time Factors; D014465:Ultrasonics
D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D048271:Chitosan; D010100:Oxygen