Air pollution and antibodies against modified lipoproteins are associated with atherosclerosis and vascular remodeling in hyperlipemic mice.
We analyzed the impact of chronic exposure to urban air pollution on the development of atherosclerosis. Hyperlipemic mice (LDLR(-/-)) were submitted to a high fat diet and air pollution for four months. We measured the susceptibility of LDL to oxidative modifications (TBARS), the presence of anti-oxLDL and an apoB-derived peptide (apoB-D) in blood and the degree of atherosclerosis in the aortic arch. Air pollution increased the susceptibility of LDL to oxidation as well as anti-oxLDL and anti-apo-B levels. These levels were even higher than in mice submitted to a high fat diet and non-polluted air. The lipid content of the atherosclerotic plaques in the aorta was increased in groups with a high cholesterol diet independently of the air quality. However, the thickness of the arterial wall was greater in mice fed a high lipid diet with polluted air. Thus, we conclude that urban air pollution exacerbates the susceptibility of LDL to oxidation, atherogenesis and vascular remodeling in hyperlipemic mice and that an immune response accompanies this process.
Soares
Sandra Regina Castro
SR
Laboratory of Soropidemiology and Immunobiology Laboratory, School of Medicine, University of São Paulo, Brazil.
Carvalho-Oliveira
Regiani
R
Ramos-Sanchez
Eduardo
E
Catanozi
Sergio
S
da Silva
Luiz Fernando Ferreira
LF
Mauad
Thaís
T
Gidlund
Magnus
M
Goto
Hiro
H
Garcia
Maria Lúcia Bueno
ML
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D000906:Antibodies / Q000097:blood*; D001011:Aorta / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D001018:Aortic Diseases / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D001055:Apolipoproteins B / Q000276:immunology*; D050197:Atherosclerosis / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D001273:Atmosphere Exposure Chambers; D049109:Cell Proliferation; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000150:complications* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D019570:Inhalation Exposure; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011973:Receptors, LDL / Q000172:deficiency / Q000235:genetics; D013997:Time Factors
D000393:Air Pollutants; D000906:Antibodies; D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; C099252:oxidized low density lipoprotein