title: Transgeneration effects of antenatal acute hypoxia during early organogenesis.
abstract: We studied the effect of acute hypobaric hypoxia in early organogenesis on physiological and behavioral parameters of second-generation albino rats. Antenatal acute hypoxia was followed by physical and sexual retardation, increase in the mortality rate, and behavioral changes in second-generation animals (hypoactivity of males and females on day 22 of life and hyperactivity of males on day 57 of life). Second-generation animals exhibited no gender differences in body weight and horizontal and vertical locomotor activity.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia. connie-phys@mail.ru
authors.forename: T Yu
authors.initials: TY
authors.lastname: Dunaeva
authors.forename: L K
authors.initials: LK
authors.lastname: Trofimova
authors.forename: A V
authors.initials: AV
authors.lastname: Graf
authors.forename: M V
authors.initials: MV
authors.lastname: Maslova
authors.forename: A S
authors.initials: AS
authors.lastname: Maklakova
authors.forename: Ya V
authors.initials: YV
authors.lastname: Krushinskaya
authors.forename: N A
authors.initials: NA
authors.lastname: Sokolova
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity; D038081:Organogenesis / Q000502:physiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012737:Sex Factors