title: Current advances in identification of cancer biomarkers in saliva.
abstract: Saliva samples from certain disease patients harbor a wide spectrum of proteins, mRNAs, DNAs and other molecules that may be associated with the disease phenotype. If successfully discovered and validated, these informative molecules may serve as biomarkers, leading to the use of non-invasive biofluid for detecting and monitoring the diseases. This article summarizes the current advances in searching for potential biomarkers in saliva for human cancers, especially head and neck/oral cancers. With the new molecular profiling technologies such as microarray and proteomics, we are expecting to reveal highly discriminatory genomic and proteomic targets that can best detect the disease status.
authors.affiliation: School of Dentistry and Dental Research Institute, University of California at Los Angeles, Los Angeles CA 90095, USA.
authors.forename: Martha
authors.initials: M
authors.lastname: Arellano
authors.forename: Jiang
authors.initials: J
authors.lastname: Jiang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhou
authors.forename: Lifeng
authors.initials: L
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Ye
authors.forename: David T
authors.initials: DT
authors.lastname: Wong
authors.forename: Shen
authors.initials: S
authors.lastname: Hu
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D040901:Proteomics; D012463:Saliva / Q000737:chemistry*
chemical_list: D014408:Biomarkers, Tumor