title: Cell responses to bone morphogenetic proteins and peptides derived from them: biomedical applications and limitations.
abstract: The bone morphogenetic proteins (BMPs) are cytokines of the transforming growth factor beta family. Some BMPs such as BMP-2 and BMP-7 play a major role in the development of the skeleton and the maintenance of homeostasis during bone remodelling. To date, only BMP-2 and BMP-7 have been approved by the Food and Drug Administration for specific orthopaedic applications. However, due to BMP cost, peptides derived from their knuckle epitope with osteogenic properties have been developed. BMPs are involved in many other biological events, including embryogenesis, angiogenesis and cancer. BMPs therefore have great biomedical potential as osteogenic factors and as anti-cancer agents. This review focuses on the use of BMPs and their derived peptides in biomedical delivery systems and gene therapy.
authors.affiliation: Department of Chemical Engineering and Biotechnological Engineering, Université de Sherbrooke, QC, Canada. Helena.Senta@usherbrooke.ca
authors.forename: H
authors.initials: H
authors.lastname: Senta
authors.forename: H
authors.initials: H
authors.lastname: Park
authors.forename: E
authors.initials: E
authors.lastname: Bergeron
authors.forename: O
authors.initials: O
authors.lastname: Drevelle
authors.forename: D
authors.initials: D
authors.lastname: Fong
authors.forename: E
authors.initials: E
authors.lastname: Leblanc
authors.forename: F
authors.initials: F
authors.lastname: Cabana
authors.forename: S
authors.initials: S
authors.lastname: Roux
authors.forename: G
authors.initials: G
authors.lastname: Grenier
authors.forename: N
authors.initials: N
authors.lastname: Faucheux
mesh_terms: D019485:Bone Morphogenetic Proteins / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008954:Models, Biological; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D051785:Smad Proteins / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D010455:Peptides; D011994:Recombinant Proteins; D051785:Smad Proteins