Cation-triggered drug release from a porous zinc-adeninate metal-organic framework.
A porous anionic metal-organic framework, bio-MOF-1, constructed using adenine as a biomolecular building block is described. The porosity of this material is evaluated, its stability in biological buffers is studied, and its potential as a material for controlled drug release is investigated. Specifically, procainamide HCl is loaded into the pores of bio-MOF-1 using a simple cation exchange process. Exogenous cations from biological buffers are shown to affect the release of the adsorbed drug molecules.
An
Jihyun
J
Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA.
Geib
Steven J
SJ
Rosi
Nathaniel L
NL
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011342:Procainamide / Q000008:administration & dosage / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D000889:Anti-Arrhythmia Agents; D001713:Biphenyl Compounds; D002412:Cations; D003692:Delayed-Action Preparations; D009942:Organometallic Compounds; D015032:Zinc; D000225:Adenine; D011342:Procainamide