title: The augmenting activity of 6-(methylsulfinyl)hexyl isothiocyanate on cellular glutathione levels is less sensitive to thiol compounds than its cytotoxic activity.
abstract: We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC). Thiol compounds abolished the cytotoxic activity of 6-MITC, but did not abolish its activity augmenting cellular total glutathione levels and gamma-glutamylcysteine ligase gene expression. Thiol compounds might play an important role in the augmentation of several significant biological activities by overcoming the inherent limitations of 6-MITC.
authors.affiliation: Department of Clinical Pharmacy, Aomori University, Aomori, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kidachi
authors.forename: Toshiro
authors.initials: T
authors.lastname: Noshita
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Hironori
authors.initials: H
authors.lastname: Umetsu
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fuke
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ryoyama
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D005978:Glutathione / Q000378:metabolism*; D017879:Isothiocyanates / Q000494:pharmacology*; D051379:Mice; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
chemical_list: C505386:6-(Methylsulfinyl)hexyl isothiocyanate; D017879:Isothiocyanates; D013438:Sulfhydryl Compounds; D005978:Glutathione