title: Is early laparoscopic cholecystectomy safe after the "safe period"?
abstract: BACKGROUND
  Early laparoscopic cholecystectomy (ELC) in acute cholecystitis improves hospital stay and outcome. Operative difficulty is said to increase with delay, and surgery is usually advised within 3 days of presentation. It can be difficult to accommodate all these patients within 3 days; this study evaluates results within and after this "safe period."
  
  
  METHODS
  In total, 137 patients (male:female 45:92) presenting as an emergency due to acute cholecystitis over 45 months from August 1, 2003, who then underwent ELC with an on-table cholangiogram (OTC) or laparoscopic ultrasound were prospectively studied. Outcome was compared between those who underwent surgery within 72 hours (group 1) or after 72 hours (group 2).
  
  
  RESULTS
  There were 87 patients in group 1 versus 50 in group 2. There was no significant difference with reference to ASA grading, length of operation (median 90 vs. 90 minutes; P = 1.000), conversion rates (7 vs. 10%; P = 0.523), median postoperative stay (2 vs. 3 days; P = 0.203), or 30-day readmission rates [5/87 [6%] vs. 3/50 [6%]; P = 1.000] between groups, respectively. There was no mortality. One patient had a biliary leak from a duct of Lushka in group 2, which settled after endoscopic stenting.
  
  
  CONCLUSIONS
  In experienced hands, ELC is safe even after 72 hours.
authors.affiliation: Department of General Surgery, Yeovil District Hospital NHS Foundation Trust, Yeovil, United Kingdom.
authors.forename: Tahir
authors.initials: T
authors.lastname: Farooq
authors.forename: Gordon
authors.initials: G
authors.lastname: Buchanan
authors.forename: Vijay
authors.initials: V
authors.lastname: Manda
authors.forename: Robin
authors.initials: R
authors.lastname: Kennedy
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ockrim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017081:Cholecystectomy, Laparoscopic; D041881:Cholecystitis, Acute / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D006113:United Kingdom; D055815:Young Adult