[Mu-opioidergic immunomodulation: the neurochemical basis].
The review summarizes information from literature and results of autor's own investigation concerning the influence of the selective mu-opioid agonists (beta-endorphin, morphine, DAGO) on immune status. The neurochemical mechanisms of the interaction between the mu-opioidergic and neuromediator systems are discussing. The participation of the dopaminergic mechanisms in mu-opioid-induced changes of immunological reactivity is revealed also.
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D000818:Animals; D001921:Brain / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology*; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007155:Immunologic Factors / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000819:agonists* / Q000378:metabolism; D001615:beta-Endorphin / Q000494:pharmacology*
D007155:Immunologic Factors; D011954:Receptors, Dopamine; D018079:Receptors, GABA; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D001615:beta-Endorphin; D009020:Morphine; D004298:Dopamine