Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain.
There is growing evidence that low vitamin D impacts adversely on brain development. The current study investigated the impact of developmental vitamin D (DVD) deficiency on dopamine and serotonin metabolism in the neonatal rat brain. DVD-deficiency resulted in an altered dopaminergic metabolic profile in the forebrain, with a decrease in the conversion of dihydroxyphenylacetic acid (DOPAC) to homovanillic acid (HVA). Correspondingly, expression of the enzyme required for this conversion, catechol-O-methyl transferase (COMT), was decreased. These results suggest that DVD-deficiency influences dopamine turnover during development.
Kesby
James P
JP
School of Biomedical Science, University of Queensland, Qld 4072, Australia.
Cui
Xiaoying
X
Ko
Pauline
P
McGrath
John J
JJ
Burne
Thomas H J
TH
Eyles
Darryl W
DW
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D002394:Catechol O-Methyltransferase / Q000096:biosynthesis; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008636:Mesencephalon / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D008995:Monoamine Oxidase / Q000096:biosynthesis; D009638:Norepinephrine / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D016548:Prosencephalon / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism; D015398:Signal Transduction; D014808:Vitamin D Deficiency / Q000196:embryology / Q000378:metabolism*
D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid