title: Assessing the feasibility of targeted selective treatments for gastrointestinal nematodes in first-season grazing cattle based on mid-season daily weight gains.
abstract: A retrospective study was carried out to assess the possibility of using daily weight gain in first-season grazing cattle (FSG) as a marker for treatment decisions to prevent parasite-induced losses caused by gastrointestinal (GI) nematodes. This is intended as a proof of concept for using targeted selective treatments (TSTs) in the control of veterinary parasites. Historical data were combined from three independent grazing trials in Sweden, each of which was repeated over 2-3 years, in order to investigate the influences of parasites on the performance of FSG cattle subjected to different levels of parasite control. In general, the different trials and years produced congruent results. There was a good positive linear relationship between daily weight gains (Dwgt) registered around housing and those recorded in the middle of the grazing season (r(2)=0.54) but not between early-season Dwgt and housing Dwgt. The latter observation emphasizes that factors other than nematode infection influence the final weight of the cattle. However, significant differences in Dwgt ( approximately 0.2 kg/day) were also observed depending on the nematode-control level achieved. At selected time points, the mean number of trichostrongylid eggs, serum pepsinogen concentration and Ostertagia antibody levels were significantly higher in animals with poor performance. ROC analyses showed that anthelmintic treatment of animals with a Dwgt of <0.75 kg/day by mid-season had a sensitivity of approximately 70% and a specificity of approximately 50%. It thus seems feasible to base a targeted selective treatment for FSG cattle on Dwgt recorded approximately 4-8 weeks after turn-out, provided that it is accepted that some animals will be dewormed without indication. This now needs to be tested in controlled field trials.
authors.affiliation: Section of Parasitology (SWEPAR), Swedish University of Agricultural Sciences, SE-751 89 Uppsala, Sweden. Johan.Hoglund@bvf.slu.se
authors.forename: Johan
authors.initials: J
authors.lastname: Höglund
authors.forename: David A
authors.initials: DA
authors.lastname: Morrison
authors.forename: Johannes
authors.initials: J
authors.lastname: Charlier
authors.forename: Sten-Olof
authors.initials: SO
authors.lastname: Dimander
authors.forename: Anna
authors.initials: A
authors.lastname: Larsson
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000469:parasitology / Q000662:veterinary*; D008954:Models, Biological; D012189:Retrospective Studies; D012621:Seasons; D013548:Sweden; D013997:Time Factors; D015430:Weight Gain / Q000502:physiology*
chemical_list: D000871:Anthelmintics