[Pancytopenia, hepatosplenomegaly and dry cough after breast cancer].
METHODS
A 71-year-old woman had suffered for 6 weeks from fatigue, dry cough and fever. Five years previously breast cancer had been diagnosed and had been successfully treated with subtotal mastectomy and postoperative radiotherapy, as well as aromatase inhibitor until shortly before the present admission. There was no history of travel to tropical countries, but during the last summer she had spent two weeks in Northern Italy. [corrected]


METHODS
On admission the body temperature was 38,5 C with a mild tachycardia (108/min). Laboratory findings revealed a pancytopenia and slightly elevated liver enzymes. The ultrasound showed a hepatosplenomegaly. The investigation of the bone marrow showed a great amount of parasitic forms due to visceral leishmaniasis [corrected] TREATMENT, COURSE AND DIAGNOSIS: Treatment with liposomal amphotericin B brought about rapid improvement, the dry cough subsided and the laboratory results became normal.


CONCLUSIONS
Pancytopenia, fever, dry cough and hepatosplenomegaly after travelling to Mediterranean countries should raise suspicion of visceral leishmaniasis. This diagnosis is confirmed by direct detection of the parasite in the bone marrow. Administration of liposomal amphotericin B is efficacious and safe, bringing about full recovery in up to 90% of cases.
Seilmaier
M
M
Medizinische Klinik, Klinik für Hämatologie, Onkologie, Immunologie, Palliativmedizin, Infektiologie, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universität München, München. drmseil@gmx.net
Hecht
A
A
Guggemos
W
W
Adorf
D
D
Gehbauer
G
G
D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage; D000981:Antiprotozoal Agents / Q000008:administration & dosage; D047072:Aromatase Inhibitors / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003371:Cough; D003937:Diagnosis, Differential; D005221:Fatigue; D005260:Female; D005334:Fever; D006529:Hepatomegaly; D006801:Humans; D007558:Italy; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000188:drug therapy; D008081:Liposomes; D015412:Mastectomy, Segmental; D010198:Pancytopenia; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D013163:Splenomegaly; D013610:Tachycardia; D014195:Travel
D000981:Antiprotozoal Agents; D047072:Aromatase Inhibitors; D008081:Liposomes; D000666:Amphotericin B