title: Cycloartane triterpenoids from Kleinhovia hospita.
abstract: Four new cycloartane triterpenoids, together with the known gardenolic acid B, were isolated from Kleinhovia hospita. The triterpenoids (1-3) contain a unique 21,23-diacetal side-chain, while compound 4 contains two alpha,beta-unsaturated ketone moieties. Their structures and relative configurations were determined by spectroscopic methods, including 2D NMR and IR. These compounds showed promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.
authors.affiliation: Institute of Modern Chinese Medicine (IMCM), College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People's Republic of China.
authors.forename: Li-She
authors.initials: LS
authors.lastname: Gan
authors.forename: Gang
authors.initials: G
authors.lastname: Ren
authors.forename: Jian-Xia
authors.initials: JX
authors.lastname: Mo
authors.forename: Xiang-Yi
authors.initials: XY
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Yao
authors.forename: Chang-Xin
authors.initials: CX
authors.lastname: Zhou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects; D019660:Malvaceae / Q000737:chemistry*; D015394:Molecular Structure; D009582:Nitrofurantoin / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C085352:cycloartane; D009582:Nitrofurantoin