Diabetes and antioxidants: myth or reality?
Numerous studies have shown that increased oxidative stress (OxS) is present in diabetic patients. There is evidence that this OxS can be increased before complications associated with diabetes mellitus (DM) occur. However, the role and influence of OxS in the initiation and progression of DM remains the subject of debate. It has been suggested that in DM, OxS is caused by increased production of reactive oxygen species (ROS), and associated with reduction in antioxidant defenses and altered cellular redox status. Acute and chronic OxS which could enhance the development of complications associated with DM. This review considers recent findings on the role of antioxidants in controlling OxS and the incidence of DM with emphasis on animal and human studies.
Haidara
Mohamed A
MA
Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia. haidaram@hotmail.com
Yassin
Hanaa Z
HZ
Zakula
Zorica
Z
Mikhailidis
Dimitri P
DP
Isenovic
Esma R
ER
D000818:Animals; D000975:Antioxidants / Q000502:physiology* / Q000627:therapeutic use*; D048909:Diabetes Complications / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control*; D018450:Disease Progression; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D017382:Reactive Oxygen Species