title: Increased incidence of leprosy following HAART initiation: a manifestation of the immune reconstitution disease.
abstract: A retrospective cohort study was conducted to determine whether the incidence of leprosy varied with the duration of antiretroviral therapy (ART). Between 1992 and 2006, seven cases of leprosy were observed. The incidence of leprosy in untreated patients was 0.7 per 1000 person-years, 13 per 1000 person-years in persons receiving HAART for more than 3 months and 0.9 per 1000 person-years for persons receiving HAART for more than 3 months. The adjusted hazard ratio was 18.5 (95% confidence interval, 1.6-217) with P = 0.02. In tropical areas where HAART is increasingly available, physicians should be aware of the possibility of incident leprosy shortly after HAART initiation.
authors.affiliation: Service de Dermatologie, Institut Guyanais de Dermatologie Tropicale, French Guiana.
authors.forename: Pierre
authors.initials: P
authors.lastname: Couppié
authors.forename: Valérie
authors.initials: V
authors.lastname: Domergue
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Clyti
authors.forename: Myriam
authors.initials: M
authors.lastname: El Guedj
authors.forename: Tania
authors.initials: T
authors.lastname: Vaz
authors.forename: Dominique
authors.initials: D
authors.lastname: Sainte-Marie
authors.forename: Christian
authors.initials: C
authors.lastname: Marty
authors.forename: Mathieu
authors.initials: M
authors.lastname: Nacher
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000453:epidemiology; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D004812:Epidemiologic Methods; D005260:Female; D005616:French Guiana / Q000453:epidemiology; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000453:epidemiology / Q000209:etiology*; D007918:Leprosy / Q000150:complications* / Q000453:epidemiology; D008297:Male