title: Miscarriage after invasive prenatal diagnostic procedures: how much risk our pregnant women are willing to take?
abstract: OBJECTIVE
  To elicit the level of risk of prenatal diagnostic procedure-related miscarriage that Chinese pregnant women were willing to accept.
  
  
  METHODS
  An interviewer-administered survey was conducted on 276 women who presented to the University Obstetric Unit. Using the standard gamble approach, subjects were asked to choose between a screening test with a 90% detection rate and a diagnostic test which is definitive but carries a finite risk of abortion. This probability of abortion was varied until the subject was indifferent between the two choices, and the value was called the utility score.
  
  
  RESULTS
  When compared with a screening test with 90% detection rate, the median utility score was 0.989 (IQR: 0.970-0.999). The median risk of abortion below which the subjects would rather opt for an invasive test instead of a screening test was 1.1%. The percentage of patients who could accept a procedure-related miscarriage risk of 0.2, 0.5, 1 and 2% were 76, 67, 59.8 and 38.4%, respectively.
  
  
  CONCLUSIONS
  Pregnant Chinese women agreed to trade a definitive chromosomal diagnostic test from a highly effective screening test with a small risk of undiagnosed aneuploidy provided that the procedure-related miscarriage risk was 1.1% or lower.
authors.affiliation: Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China. chanyiuman@cuhk.edu.hk
authors.forename: Yiu Man
authors.initials: YM
authors.lastname: Chan
authors.forename: Daljit Singh
authors.initials: DS
authors.lastname: Sahota
authors.forename: Oi Ka
authors.initials: OK
authors.lastname: Chan
authors.forename: Tak Yeung
authors.initials: TY
authors.lastname: Leung
authors.forename: Tze Kin
authors.initials: TK
authors.lastname: Lau
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D000328:Adult; D002681:China; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects / Q000523:psychology / Q000706:statistics & numerical data; D006801:Humans; D011247:Pregnancy; D037841:Pregnant People / Q000523:psychology*; D011296:Prenatal Diagnosis / Q000009:adverse effects* / Q000379:methods* / Q000523:psychology / Q000706:statistics & numerical data; D012309:Risk-Taking; D012923:Social Class