title: Testicular adrenal rest tumours in congenital adrenal hyperplasia.
abstract: In adult patients with congenital adrenal hyperplasia (CAH) the presence of testicular adrenal rest tumours (TART) is an important cause of gonadal dysfunction and infertility. In the last decade several papers have focused on the origin and pathogenesis of these tumours. In this paper we review the embryological, histological, biochemical and clinical features of TART and discuss the treatment options. Furthermore, we propose a new five-stage classification of TART, based on sonographic, clinical and biochemical parameters, that may lead to a better follow up and treatment of patients with TART.
authors.affiliation: Department of Paediatric Endocrinology, Radboud University Nijmegen Medical Centre, The Netherlands. h.claahsen@cukz.umcn.nl
authors.forename: H L
authors.initials: HL
authors.lastname: Claahsen-van der Grinten
authors.forename: B J
authors.initials: BJ
authors.lastname: Otten
authors.forename: M M L
authors.initials: MM
authors.lastname: Stikkelbroeck
authors.forename: F C G J
authors.initials: FC
authors.lastname: Sweep
authors.forename: A R M M
authors.initials: AR
authors.lastname: Hermus
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000150:complications* / Q000473:pathology / Q000628:therapy; D000314:Adrenal Rest Tumor / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy; D013736:Testicular Neoplasms / Q000209:etiology* / Q000473:pathology / Q000628:therapy