title: Conversion from mycophenolate mofetil to delayed formulation in pediatric renal transplantation: higher mycophenolic acid predose level but no changes in the immune biomarkers.
abstract: EC-MPS was designed to improve MPA-related GII because of MMF, by delaying the release of MPA until reaching the small intestine. At present, its immunosuppressive activity in pediatric renal transplant recipients with GII has not been clarified. We studied eight renal transplant recipients before and after three months of the conversion from MMF to equimolar doses of EC-MPS. After three months of treatment with EC-MPA, GII decreased between 100% and 12.5%. The predose levels of MPA were about 60% higher on EC-MPS (6.9 +/- 1.1 microg/mL) compared with MMF administration (4.2 +/- 0.9 microg/mL). Hemoglobin decreased significantly post-conversion (12.0 +/- 0.4 to 11.0 +/- 0.5 g/dL). Serum creatinine, creatinine clearance, and urinary protein excretion did not change. Also, proliferative response and cytotoxic antibodies showed no significant change. The release of interleukin-10 was strikingly augmented with MMF or EC-MPS therapy; meanwhile, gamma-interferon and TNF were low under both treatments. Our data indicate that conversion from MMF to EC-MPS leads to an improvement in GII without altering key elements of immunosuppression.
authors.affiliation: Departamento de Pediatría, Hospital Italiano, Universidad de Buenos Aires, Buenos Aires, Argentina. jorge.ferraris@hospitalitaliano.org.ar
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Ferraris
authors.forename: Mónica L
authors.initials: ML
authors.lastname: Tambutti
authors.forename: Norma
authors.initials: N
authors.lastname: Prigoshin
authors.forename: Mauricio
authors.initials: M
authors.lastname: Grosman
authors.forename: Rita L
authors.initials: RL
authors.lastname: Cardoni
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D016207:Cytokines / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007107:Immune System; D007371:Interferon-gamma / Q000378:metabolism; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013608:Tablets, Enteric-Coated / Q000627:therapeutic use; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines; D003692:Delayed-Action Preparations; D006454:Hemoglobins; D013608:Tablets, Enteric-Coated; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D003404:Creatinine; D009173:Mycophenolic Acid