Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc.
Allogeneic hematopoietic cell transplantation represents an important therapy for certain malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a major cause of mortality and morbidity. The search for agents that can efficiently suppress GVHD has been going on for more than half a century. GVHD is particularly strong in xenogeneic donor-recipient combinations, given the unlimited number of potentially immunogenic antigens donor lymphocytes encounter in the host. Using a hu-nonobese diabetic/severe combined immunodeficiency (hu-NOD/SCID) gamma-null model of xenogeneic GVHD, we have demonstrated that treatment with recombinant immunoglobulin-like transcript 3-Fc protein induces the differentiation of CD8(+) T suppressor cells and blocks the cellular and humoral arm of the GVH reaction.
Vlad
George
G
Department of Pathology, Columbia University, New York, NY 10032, USA.
Stokes
Michael B
MB
Liu
Zhuoru
Z
Chang
Chih-Chao
CC
Sondermeijer
Hugo
H
Vasilescu
Elena R
ER
Colovai
Adriana I
AI
Berloco
Pasquale
P
D'Agati
Vivette D
VD
Ratner
Lloyd
L
Cortesini
Raffaello
R
Suciu-Foca
Nicole
N
D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology; D015478:Antigens, Heterophile / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation / Q000235:genetics; D018450:Disease Progression; D005260:Female; D005818:Genetic Engineering; D006086:Graft vs Host Disease / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D007166:Immunosuppressive Agents / Q000276:immunology / Q000378:metabolism; D007167:Immunotherapy; D008562:Membrane Glycoproteins; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D011828:Radiation Chimera; D011956:Receptors, Cell Surface / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011971:Receptors, Immunologic; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000473:pathology
D000910:Antibodies, Heterophile; D015478:Antigens, Heterophile; D007141:Immunoglobulin Fc Fragments; D007166:Immunosuppressive Agents; C107907:LILRB4 protein, human; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D011993:Recombinant Fusion Proteins