title: Tinea capitis: predictive value of symptoms and time to cure with griseofulvin treatment.
abstract: OBJECTIVE
  To describe (a) the predictive value of symptoms for diagnosis of tinea capitis and (b) the rate and timing of cure with high-dose griseofulvin treatment.
  
  
  METHODS
  This prospective open-label study enrolled children aged 1 to 12 years with clinical tinea capitis. Participants with a positive dermatophyte culture received oral griseofulvin (20-25 mg/kg/day) and topical selenium sulfide shampoo for 6 weeks. Main outcome measures. The rate of symptoms of tinea capitis, and rates of mycologic and clinical cure.
  
  
  RESULTS
  The positive predictive values of any 1, 2, 3, or 4 symptoms for a positive culture were 88%, 82%, 78%, and 77%, respectively. The observed rates of mycologic, clinical, and complete cure were 89%, 66%, and 49%, respectively. conclusion: In a high-risk population it is reasonable to diagnose tinea capitis using one or more cardinal symptoms. Oral griseofulvin at 20 to 25 mg/ kg/day with adjunctive shampooing for 6 weeks is moderately successful as treatment.
authors.affiliation: Department of Pediatrics, Rainbow Babies and Children's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
authors.forename: Kelly C
authors.initials: KC
authors.lastname: Lorch Dauk
authors.forename: Elana
authors.initials: E
authors.lastname: Comrov
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Blumer
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: O'Riordan
authors.forename: Lydia M
authors.initials: LM
authors.lastname: Furman
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006118:Griseofulvin / Q000008:administration & dosage / Q000627:therapeutic use*; D006203:Hair Preparations / Q000494:pharmacology; D006801:Humans; D007223:Infant; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018036:Selenium Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D014006:Tinea Capitis / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D014249:Trichophyton / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D006203:Hair Preparations; D018036:Selenium Compounds; D006118:Griseofulvin