Recent developments of biodegradable and biocompatible materials based micro/nanoparticles for delivering macromolecular therapeutics.
Developments in biotechnology have seen the growing use of macromolecules containing proteins, peptides, vaccines, antigens, genes, and growth factors as therapeutic agents. Because these macromolecules are easily denatured and metabolized rapidly in vivo, their protection and controlled release are required. Biodegradable and biocompatible materials based micro/nanoparticles (MPs/NPs) show great potential for delivering macromolecular therapeutics. One of the greatest challenges in the delivery of macromolecules from biodegradable and biocompatible MPs/NPs is the controlled and complete release of the drugs in their native forms. Unfortunately, the present drug delivery systems cannot satisfy the requirement; thus, more research is expected. This article discusses the recent developments in the field of macromolecular delivery.
Shi
Yang
Y
Pharmaceutical College, Shandong University, Ji'nan 250012, China.
Huang
Guihua
G
D000818:Animals; D001709:Biotechnology / Q000379:methods; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D006801:Humans; D008863:Microspheres; D053758:Nanoparticles; D010316:Particle Size; D014612:Vaccines / Q000008:administration & dosage
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D014612:Vaccines