title: Influence of concentration of fragrances on salivary alpha-amylase.
abstract: The objective is to reveal the influence of the concentration of fragrances on salivary biomarkers, which reflect the human stress system, in 15 female young healthy adults. Lavandula officinalis and Citrus aurantium were used as the test samples. Salivary biomarkers such as alpha-amylase activity (AMY), cortisol (CORT) and dehydroepiandrosterone (DHEA) were measured during baseline, inhalation and post-inhalation periods. Our results indicated that (i) a significant difference was not observed for the control and the 3 wt% test samples, however, the AMY was decreased by inhalation of the 1 wt% test samples (P < 0.05); (ii) AMY levels changed more significantly than did the hormone levels; (iii) a tendency of negative correlation was not observed between DHEA and CORT. It was considered that the time-course change of AMY might be a useful index of the inhalation of fragrances, which reflects the acute psychosomatic reactivity of humans.
authors.affiliation: Graduate School of Engineering, Iwate University, Morioka, University of Toyama, Toyama, Japan. masakiy@iwate-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Tahara
authors.forename: S
authors.initials: S
authors.lastname: Kosaka
mesh_terms: D000328:Adult; D002957:Citrus / Q000737:chemistry*; D003687:Dehydroepiandrosterone / Q000032:analysis / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis / Q000378:metabolism; D027523:Lavandula / Q000737:chemistry*; D009822:Oils, Volatile / Q000494:pharmacology*; D012469:Salivary Glands / Q000187:drug effects* / Q000201:enzymology*; D055291:Salivary alpha-Amylases / Q000032:analysis* / Q000378:metabolism; D018709:Statistics, Nonparametric; D013312:Stress, Physiological / Q000187:drug effects*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D009822:Oils, Volatile; D003687:Dehydroepiandrosterone; D055291:Salivary alpha-Amylases; D006854:Hydrocortisone