Isolated ovarian relapse of pre-B acute lymphoblastic leukemia: a case report.
BACKGROUND
Acute lymphoblastic leukemia is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace normal marrow hematopoietic cells, resulting in a marked decrease in the production of normal blood cells.


METHODS
We report a case of isolated ovarian relapse 7 years after the primary diagnosis in a patient, who was seemingly in clinical remission following unilateral ovariectomy and second-line chemotherapy.


CONCLUSIONS
In contrast to testicular relapse, ovarian relapses in acute lymphoblastic leukemia are rarely reported. Surgical removal of the mass followed by chemotherapy is the therapeutic standard.
Berretta
Roberto
R
Department of Obstetrics and Gynecology, University of Parma, Parma via gramsci 14 -43100, Italy. rberretz@tin.it
Barone
Angelica
A
Rolla
Martino
M
Bertolini
Patrizia
P
Nardelli
Giovanni Battista
GB
D000293:Adolescent; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D010052:Ovariectomy; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery