title: Comparison of diffusion-weighted images using short inversion time inversion recovery or chemical shift selective pulse as fat suppression in patients with breast cancer.
abstract: OBJECTIVE
  Fat suppression is essential for diffusion-weighted imaging (DWI) in the body. However, the chemical shift selective (CHESS) pulse often fails to suppress fat signals in the breast. The purpose of this study was to compare DWI using CHESS and DWI using short inversion time inversion recovery (STIR) in terms of fat suppression and the apparent diffusion coefficient (ADC) value.
  
  
  METHODS
  DWI using STIR, DWI using CHESS, and contrast-enhanced T1-weighted images were obtained in 32 patients with breast carcinoma. Uniformity of fat suppression, ADC, signal intensity, and visualization of the breast tumors were evaluated.
  
  
  RESULTS
  In 44% (14/32) of patients there was insufficient fat suppression in the breasts on DWI using CHESS, whereas 0% was observed on DWI using STIR (P < 0.0001). The ADCs obtained for DWI using STIR were 4.3% lower than those obtained for DWI using CHESS (P < 0.02); there was a strong correlation of the ADC measurement (r = 0.93, P < 0.001).
  
  
  CONCLUSIONS
  DWI using STIR may be excellent for fat suppression; and the ADC obtained in this sequence was well correlated with that obtained with DWI using CHESS. DWI using STIR may be useful when the fat suppression technique in DWI using CHESS does not work well.
authors.affiliation: Department of Radiology, National Cancer Center Hospital East, Kashiwa, Japan. kazamat@fg7.so-net.ne.jp
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kazama
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Nasu
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kuroki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nawano
authors.forename: Hisao
authors.initials: H
authors.lastname: Ito
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media