title: Perfusion imaging in Pusher syndrome to investigate the neural substrates involved in controlling upright body position.
abstract: Brain damage may induce a dysfunction of upright body position termed "pusher syndrome". Patients with such disorder suffer from an alteration of their sense of body verticality. They experience their body as oriented upright when actually tilted nearly 20 degrees to the ipsilesional side. Pusher syndrome typically is associated with posterior thalamic stroke; less frequently with extra-thalamic lesions. This argued for a fundamental role of these structures in our control of upright body posture. Here we investigated whether such patients may show additional functional or metabolic abnormalities outside the areas of brain lesion. We investigated 19 stroke patients with thalamic or with extra-thalamic lesions showing versus not showing misperception of body orientation. We measured fluid-attenuated inversion-recovery (FLAIR) imaging, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI). This allowed us to determine the structural damage as well as to identify the malperfused but structural intact tissue. Pusher patients with thalamic lesions did not show dysfunctional brain areas in addition to the ones found to be structurally damaged. In the pusher patients with extra-thalamic lesions, the thalamus was neither structurally damaged nor malperfused. Rather, these patients showed small regions of abnormal perfusion in the structurally intact inferior frontal gyrus, middle temporal gyrus, inferior parietal lobule, and parietal white matter. The results indicate that these extra-thalamic brain areas contribute to the network controlling upright body posture. The data also suggest that damage of the neural tissue in the posterior thalamus itself rather than additional malperfusion in distant cortical areas is associated with pusher syndrome. Hence, it seems as if the normal functioning of both extra-thalamic as well as posterior thalamic structures is integral to perceiving gravity and controlling upright body orientation in humans.
authors.affiliation: Section of Neuropsychology, Center of Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
authors.forename: Luca Francesco
authors.initials: LF
authors.lastname: Ticini
authors.forename: Uwe
authors.initials: U
authors.lastname: Klose
authors.forename: Thomas
authors.initials: T
authors.lastname: Nägele
authors.forename: Hans-Otto
authors.initials: HO
authors.lastname: Karnath
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000503:physiopathology*; D000368:Aged; D001931:Brain Mapping; D003710:Demography; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009420:Nervous System / Q000503:physiopathology*; D010477:Perfusion / Q000379:methods*; D011187:Posture / Q000502:physiology*; D013577:Syndrome; D013788:Thalamus / Q000473:pathology