AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans.
Previous evidence suggests that the dual-specific A kinase-anchoring protein 2 functional polymorphism (AKAP10 (A/G) I646V) influences heart rate (HR) and heart rate variability (HRV) in mice and humans (N=122) with cardiovascular disease. Here, we asked whether this AKAP10 variant predicts HR and HRV in a large sample of healthy humans. Resting HR and short-term time and frequency domain measures of HRV (5 min during paced and unpaced respiration conditions) were assessed in a U.S. community sample (N=1,033) of generally healthy men and women (age 30-54) of European ancestry. Each person was genotyped for the AKAP10 variant. As with previous work, the AKAP10 Val allele predicted greater resting HR (Paced p<.01; Unpaced p<.03) and diminished HRV (Paced ps <.05) suggesting that this variant may modulate the sensitivity of cardiac pacemaker cells to autonomic inputs, possibly conferring risk for arrhythmias and sudden cardiac death.
Neumann
Serina A
SA
Eastern Virginia Medical School, Norfolk, Virginia 23507, USA. neumansa@evms.edu
Tingley
Whittemore G
WG
Conklin
Bruce R
BR
Shrader
Catherine J
CJ
Peet
Eloise
E
Muldoon
Matthew F
MF
Jennings
J Richard
JR
Ferrell
Robert E
RE
Manuck
Stephen B
SB
D054758:A Kinase Anchor Proteins / Q000235:genetics*; D000328:Adult; D000483:Alleles; D001341:Autonomic Nervous System / Q000502:physiology; D002304:Cardiac Pacing, Artificial; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006339:Heart Rate / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D012044:Regression Analysis; D014481:United States / Q000453:epidemiology; D044465:White People
D054758:A Kinase Anchor Proteins; C484639:AKAP10 protein, human; D004247:DNA