Loss of heterozygosity at the 9p21-24 region and identification of BRM as a candidate tumor suppressor gene in head and neck squamous cell carcinoma.
We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to be a target for deletion of the 9p21 region. However, novel frequent chromosomal deletion and a candidate tumor suppressor gene, BRM at the 9p24 region, were detected. Moreover, comparison of clinicopathological variables demonstrated that loss of heterozygosity at the BRM locus was associated with a worse prognosis.
Gunduz
Esra
E
Department of Oral Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Wakayama Medical University, Wakayama, Japan. mgunduz@md.okayama-u.ac.jp
Gunduz
Mehmet
M
Ali
Mahmoud Al Sheik
MA
Beder
Levent
L
Tamamura
Ryo
R
Katase
Naoki
N
Tominaga
Susumu
S
Yamanaka
Noboru
N
Shimizu
Kenji
K
Nagatsuka
Hitoshi
H
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002899:Chromosomes, Human, Pair 9; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D005838:Genotype; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D010641:Phenotype; D014157:Transcription Factors / Q000235:genetics*; D016896:Treatment Outcome
C084011:SMARCA2 protein, human; D014157:Transcription Factors