A graphene platform for sensing biomolecules.
Sensitive platform: The use of graphene oxide (GO) as a platform for the sensitive and selective detection of DNA and proteins is presented. The interaction of GO and dye-labeled single-stranded DNA leads to quenching of the dye fluorescence. Conversely, the presence of a target DNA or protein leads to the binding of the dye-labeled DNA and target, releasing the DNA from GO, thereby restoring the dye fluorescence (see picture).
Lu
Chun-Hua
CH
The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China.
Yang
Huang-Hao
HH
Zhu
Chun-Ling
CL
Chen
Xi
X
Chen
Guo-Nan
GN
D052157:Aptamers, Nucleotide / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D002244:Carbon / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000032:analysis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D013050:Spectrometry, Fluorescence
D052157:Aptamers, Nucleotide; D004277:DNA, Single-Stranded; D005456:Fluorescent Dyes; D011506:Proteins; D002244:Carbon