Gastroparesis, pseudoachalasia and impaired intestinal motility as paraneoplastic manifestations of small cell lung cancer.
Lung cancer is the worldwide leading cause of cancer deaths. Small cell lung cancer (SCLC) represents about 15% of lung cancers with a poor 5-year survival rate. SCLC can manifest as a paraneoplastic syndrome, which can include unexplained gastrointestinal dysmotility symptoms. The awareness of these presenting symptoms and recognition that serum markers, such as anti-Hu antibodies, mediate the paraneoplastic neuromuscular aspects of SCLC are highlighted in this case report of a patient with anti-Hu antibodies presenting with gastroparesis, pseudoachalasia, and impaired intestinal motility.
Hejazi
Reza A
RA
Department of Medicine, Kansas University Medical Center, Kansas City, Kansas, USA.
Zhang
Da
D
McCallum
Richard W
RW
D051959:ELAV Proteins / Q000378:metabolism; D004931:Esophageal Achalasia / Q000209:etiology*; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000503:physiopathology; D005769:Gastrointestinal Motility; D018589:Gastroparesis / Q000209:etiology*; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology; D008207:Lymphatic Metastasis; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology; D055752:Small Cell Lung Carcinoma / Q000150:complications* / Q000473:pathology
D051959:ELAV Proteins