title: Detection of small bowel tumors by videocapsule endoscopy in patients with acromegaly.
abstract: The prevalence of colon polyposis andmalignancies is increased in acromegalic patients as compared to the general population. An epidemiological study suggests a high prevalence also of small bowel (SB) tumors that nowadays may be detected by videocapsule endoscopy (VCE). The aim of the study was to assess the prevalence of SB neoplasms using VCE in acromegalic patients in comparison to control subjects and to correlate it with cancer risk factors and acromegaly-related parameters. Eighteen acromegalic patients (6 males and 12 females, age+/-SD: 54+/-10 yr), 5 cured after surgery (followed by radiotherapy in 3 cases) and 13 on pharmacological treatment were enrolled, and 36 sex- and age-matched non-acromegalic subjects served as a control group. Cancer risk factors, duration of acromegaly, GH and IGF-I levels, IGF binding protein 3 and IGF-II concentrations, metabolic parameters, tumor markers, colonic lesions by total colonoscopy, and SB lesions by VCE were investigated. VCE images suggestive of SB lesions were detected in 5/36 controls [14%, 4 described as gastrointestinal stromal nodular tumors (GIST), and 1 as polyp] and in 5/18 acromegalic patients [28%, 2 GIST and 3 polyps]. In acromegaly, the calculated relative risk for all SB lesions was 1.69 [95%confidence interval (CI): 0.78-3.65], while the relative risk for SB polyps was 2.50 (95% CI: 1.23-5.07). The effective duration of active disease was longer in patients with positive than in those with negative VCE (112+/-89 vs 49+/-40 months, p=0.06). In conclusion, these preliminary results suggest that acromegalic patients might have a high risk of SB polyp development. VCE might be a useful adjunctive diagnostic tool in acromegaly.
authors.affiliation: Department of Medical Sciences, University of Milan, Milan, Italy.
authors.forename: C L
authors.initials: CL
authors.lastname: Ronchi
authors.forename: F
authors.initials: F
authors.lastname: Coletti
authors.forename: E
authors.initials: E
authors.lastname: Fesce
authors.forename: L
authors.initials: L
authors.lastname: Montefusco
authors.forename: C
authors.initials: C
authors.lastname: Ogliari
authors.forename: E
authors.initials: E
authors.lastname: Verrua
authors.forename: P
authors.initials: P
authors.lastname: Epaminonda
authors.forename: E
authors.initials: E
authors.lastname: Ferrante
authors.forename: E
authors.initials: E
authors.lastname: Malchiodi
authors.forename: V
authors.initials: V
authors.lastname: Morelli
authors.forename: P
authors.initials: P
authors.lastname: Beck-Peccoz
authors.forename: M
authors.initials: M
authors.lastname: Arosio
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000150:complications* / Q000473:pathology; D001786:Blood Glucose / Q000032:analysis; D053704:Capsule Endoscopy / Q000379:methods*; D005260:Female; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007335:Insulin-Like Growth Factor II / Q000032:analysis; D007414:Intestinal Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012306:Risk; D012307:Risk Factors; D018709:Statistics, Nonparametric
chemical_list: D001786:Blood Glucose; C035170:IGF2 protein, human; C515497:IGFBP3 protein, human; D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II