Transgeneration effects of antenatal acute hypoxia during early organogenesis.
We studied the effect of acute hypobaric hypoxia in early organogenesis on physiological and behavioral parameters of second-generation albino rats. Antenatal acute hypoxia was followed by physical and sexual retardation, increase in the mortality rate, and behavioral changes in second-generation animals (hypoactivity of males and females on day 22 of life and hyperactivity of males on day 57 of life). Second-generation animals exhibited no gender differences in body weight and horizontal and vertical locomotor activity.
Dunaeva
T Yu
TY
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia. connie-phys@mail.ru
Trofimova
L K
LK
Graf
A V
AV
Maslova
M V
MV
Maklakova
A S
AS
Krushinskaya
Ya V
YV
Sokolova
N A
NA
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity; D038081:Organogenesis / Q000502:physiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012737:Sex Factors