title: Apolipoprotein E gene polymorphism in psoriasis.
abstract: Polymorphism in the apolipoprotein E gene has been associated with several neurological, cardiological and ophthalmological diseases. Apolipoprotein E is involved in psoriasis by modifying mitogen-activated T lymphocyte proliferation and by assuring protection against some infections. We evaluated the apolipoprotein E gene polymorphism in patients suffering from psoriasis (compared to matched controls) in Thrace, Northern Greece. One hundred and forty patients suffering from psoriasis vulgaris and 155 matched controls were included in this study and genotyped by semi-nested polymerase chain reaction RFLPs; the results were evaluated by conditional logistic regression. In psoriasis vulgaris patients, the e2 allele showed higher frequency (6.1%, P = 0.021) versus matched controls (2.3%). The above data were ascertained particularly enforced in psoriasis vulgaris male patients (P = 0.031) as well as in late onset psoriasis vulgaris (P = 0.029). Implication of apolipoprotein E in the pathogenesis of psoriasis has been indicated. Allele e2 is more frequent in psoriatic patients and its presence is more evident in late onset psoriasis vulgaris.
authors.affiliation: University Clinic of Dermatology, Democritus University of Thrace, Alexandroupolis 68100, Greece. karpouzis@bitservices.gr
authors.forename: Anthony
authors.initials: A
authors.lastname: Karpouzis
authors.forename: Rozina
authors.initials: R
authors.lastname: Caridha
authors.forename: Gregory
authors.initials: G
authors.lastname: Tripsianis
authors.forename: Charalambos
authors.initials: C
authors.lastname: Michailidis
authors.forename: George
authors.initials: G
authors.lastname: Martinis
authors.forename: Stavroula Vouliana
authors.initials: SV
authors.lastname: Veletza
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D053318:Apolipoprotein E3 / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D055815:Young Adult
chemical_list: D053318:Apolipoprotein E3