title: A pulmonary embolism caused by delayed-onset heparin-induced thrombocytopenia in a patient with ischemic stroke.
abstract: We report a case of an acute stroke patient with pulmonary embolism (PE) caused by delayed-onset heparin-induced thrombocytopenia (HIT). She was treated with heparin to prevent neurological deterioration. However, 5 days after heparin had been given for 7 days, she developed PE. Heparin was re-started, but the platelet count decreased significantly, and a right ventricular thrombus appeared. She was finally diagnosed as having PE due to delayed-onset HIT because the HIT antibody was positive. When a patient develops thrombotic events during or after heparin therapy, the possibility of HIT should be considered.
authors.affiliation: Department of Stroke Medicine, Kawasaki Medical School, Kurashiki. aojyun@med.kawasaki-m.ac.jp
authors.forename: Junya
authors.initials: J
authors.lastname: Aoki
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Iguchi
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kimura
authors.forename: Shinji
authors.initials: S
authors.lastname: Yamashita
authors.forename: Kensaku
authors.initials: K
authors.lastname: Shibazaki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Terasawa
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D011655:Pulmonary Embolism / Q000139:chemically induced / Q000175:diagnosis*; D020521:Stroke / Q000150:complications / Q000175:diagnosis*; D013921:Thrombocytopenia / Q000139:chemically induced / Q000175:diagnosis*
chemical_list: D003692:Delayed-Action Preparations; D006493:Heparin