BK virus nephropathy in an immunodeficient patient with chronic lymphocytic leukemia.
BACKGROUND
BK virus, genus polyomavirus, is known as an important cause of nephropathy (BKVN) in renal transplant patients. Cases of BKVN in native kidneys are rare.


OBJECTIVE
To report a case of BKVN in a patient with chronic lymphocytic leukemia (CLL) and to examine viral and immune parameters.


METHODS
Quantitative BK virus DNA in plasma and relevant immune parameters were recorded in one CLL patient with BKVN and ten consecutive CLL patients without BKVN.


RESULTS
BKVN in the native kidneys of a CLL patient was histologically confirmed. The presence of BKVN correlated with immunologic parameters as well as factors known to cause renal tissue injury. BK viral load levels in the patient steadily increased and exceeded those of the control CLL patients.


CONCLUSIONS
The results document a pathogenic role for BK virus in native kidneys of immuno-compromised CLL patients and indicate a role for quantitative BK virus DNA detection for early management of BKVN in native kidneys.
van der Bij
Akke
A
Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
Betjes
Michiel
M
Weening
Jan
J
Cornelissen
Jan
J
Mes
Ted
T
Osterhaus
Albertus
A
Beersma
Matthias
M
D001739:BK Virus / Q000302:isolation & purification*; D004279:DNA, Viral / Q000097:blood; D006801:Humans; D016867:Immunocompromised Host; D007674:Kidney Diseases / Q000473:pathology / Q000821:virology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000175:diagnosis* / Q000821:virology; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000821:virology
D004279:DNA, Viral