Quantitative 35Cl nuclear quadrupole resonance in tablets of the antidiabetic medicine Diabinese.
Pulsed (35)Cl nuclear quadrupole resonance (NQR) experiments have been performed on 250-mg tablets of the antidiabetic medicine Diabinese to establish the conditions needed for noninvasive quantitative analysis of the medicine in standard bottles. One important condition is the generation of a uniform radio-frequency (RF) field over the sample, which has been achieved by two designs of sample coil: one of variable pitch, and the other a resonator that has been fabricated from a single turn of copper sheet with a longitudinal gap bridged by tuning capacitors. The results from blind tests show that the number of tablets in a bottle could be predicted to within +/-3%.
Tate
Elizabeth
E
King's College London, Department of Mechanical Engineering, Strand, London, WC2R 2LS, United Kingdom.
Althoefer
Kaspar
K
Barras
Jamie
J
Rowe
Michael D
MD
Smith
John A S
JA
Pearce
Gareth E S
GE
Wren
Stephen A C
SA
D002713:Chlorine / Q000737:chemistry; D002747:Chlorpropamide / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry*; D007553:Isotope Labeling; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011846:Radio Waves; D013607:Tablets
D007004:Hypoglycemic Agents; D013607:Tablets; D002713:Chlorine; D002747:Chlorpropamide