Oral supplementation with dihomo-gamma-linolenic acid-enriched oil altered serum fatty acids in healthy men.
Dihomo-gamma-linolenic acid (DGLA)-enriched oil (50 or 150 mg as free DGLA) was administered to healthy men for 4 weeks. The DGLA content in serum phospholipids dose-dependently increased and returned to the initial level after a 4-week washout. No side effects or changes in platelet aggregation were observed. These results indicate that oral supplementation with DGLA oil can safely increase serum DGLA content.
Teraoka
Naoya
N
Institute for Health Care Science, Suntory Ltd., Shimamoto, Osaka, Japan.
Kawashima
Hiroshi
H
Shiraishi-Tateishi
Akiko
A
Tanaka
Takao
T
Nakamura
Junichi
J
Kakutani
Saki
S
Kiso
Yoshinobu
Y
D015126:8,11,14-Eicosatrienoic Acid / Q000008:administration & dosage* / Q000097:blood; D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000097:blood*; D006801:Humans; D008297:Male; D012016:Reference Values
D005227:Fatty Acids; D015126:8,11,14-Eicosatrienoic Acid