title: [Dynamic simulation and analysis of ERK signal pathway activated by epidermal growth factor receptor].
abstract: Extra-cellular signal regulated kinase (ERK) signal transduction is an important signaling pathway, involved in a variety of processes in cell and is closely related with the occurrence of human cancers. By the application of dynamic method, the ERK signal pathway activated by epidermal growth factor receptor (EGFR) was simulated and analyzed in this work. The influence of the mutation of adaptor protein on the expression of phosphorylated ERK signal was analyzed, and the complex coupling of the protein kinases and their kinetic function were analyzed. The obtained results are helpful to understanding the mechanism of tumor development and to finding out new target molecules in the ERK signaling system.
authors.affiliation: School of Chemical Engineering, Dalian University of Technology, Dalian 116012, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Fang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Wang
authors.forename: Shuwei
authors.initials: S
authors.lastname: Zhang
mesh_terms: D003198:Computer Simulation; D066246:ErbB Receptors / Q000378:metabolism*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D015398:Signal Transduction
chemical_list: D066246:ErbB Receptors; D048049:Extracellular Signal-Regulated MAP Kinases