title: Medicinal chemistry and therapeutic relevance of angiotensin-converting enzyme inhibitors.
abstract: Chemical Basis of Drug Action (PHA337 and PHA447) is a required 2-semester course sequence taught to second-professional year pharmacy students at Creighton University in both the campus and distance-education pathways. The course emphasizes integration of previous content, critical thinking, and therapeutic relevance. The content and learning experiences are organized to transition the students' thinking through a constructive process that provides ample opportunities to recall and integrate previous knowledge, learn and apply new knowledge, establish a logical connection between the science and its therapeutic relevance, and finally to apply the science knowledge to predict clinical activity and clinical outcomes as can be expected in a patient. This manuscript is based on the angiotensin converting enzyme inhibitors as an illustration of how our course objectives are accomplished.
authors.affiliation: School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178, USA. nalshari@creighton.edu
authors.forename: Naser Z
authors.initials: NZ
authors.lastname: Alsharif
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical / Q000193:education*; D003479:Curriculum; D003657:Decision Making; D015195:Drug Design; D020375:Education, Distance / Q000379:methods; D004512:Education, Pharmacy / Q000379:methods*; D004521:Educational Measurement; D006801:Humans; D013329:Structure-Activity Relationship; D013339:Students, Pharmacy
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors