title: Daily rhythms of left atrial pressure in beagle dogs with mitral valve regurgitation.
abstract: BACKGROUND
  Mitral valve regurgitation (MR) causes increased left atrial pressure (LAP) and is associated with occurrence of clinical signs. It will be useful to understand diurnal variations of LAP for the management of MR.
  
  
  OBJECTIVE
  Circulatory parameters and diurnal rhythm are linked to clinical signs in cardiac diseases. LAP also exhibits a diurnal rhythm in dogs with MR.
  
  
  METHODS
  Five healthy Beagle dogs weighing 9.8-12.8 kg (3 males and 2 females; aged 2 years) were used.
  
  
  METHODS
  A radiotelemetry system for continuous measurement of LAP was used in this study. Rupture of the chordae tendineae was experimentally induced via left atriotomy, and a transmitter catheter was inserted into the left atrium. The body of the transmitter was implanted SC. After clinical condition was stabilized, the severity of MR was evaluated by echocardiography, and LAP was recorded for 72 consecutive hours for the analysis of diurnal variation.
  
  
  RESULTS
  Abrupt increases in LAP, which averaged 16.7 mmHg, were observed at feeding periods. In contrast, strong diurnal LAP variations were found, with a significant but slight increase in daytime LAP compared with nighttime LAP.
  
  
  CONCLUSIONS
  Diurnal LAP is characterized by a slight but significant nocturnal decrease and abrupt increases in response to excitation. The latter seemed to be more important considering the relationship with clinical manifestations. The clinical relevance of exercise restriction in the management of MR was acknowledged.
authors.affiliation: Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: R
authors.initials: R
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Saida
authors.forename: A
authors.initials: A
authors.lastname: Soda
authors.forename: R
authors.initials: R
authors.lastname: Fukushima
authors.forename: Y
authors.initials: Y
authors.lastname: Yamane
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006325:Heart Atria; D008297:Male; D008944:Mitral Valve Insufficiency / Q000473:pathology / Q000662:veterinary*; D017725:Ventricular Pressure / Q000502:physiology*