title: Valproate-related peripheral oedema: a manageable but probably neglected condition.
abstract: Valproate-related peripheral oedema is usually regarded as a problem occurring after long-term administration of valproate. The scarcity of reports is partially responsible for the lack of a full understanding of this condition. This report describes two patients acquiring peripheral oedema after short-term use of add-on therapy with valproate. The oedema could appear and reappear quickly. Discontinuing valproate resulted in rapid improvement of this condition, and the cause-effect relationship was supported by double challenge. We also put forward a preliminary hypothesis to explain this treatable situation.
authors.affiliation: Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Shuai-Ting
authors.initials: ST
authors.lastname: Lin
authors.forename: Cheng-Sheng
authors.initials: CS
authors.lastname: Chen
authors.forename: Cheng-Fang
authors.initials: CF
authors.lastname: Yen
authors.forename: Jui-Hsiu
authors.initials: JH
authors.lastname: Tsei
authors.forename: Shing-Yaw
authors.initials: SY
authors.lastname: Wang
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy*; D004487:Edema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D013997:Time Factors; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D018692:Antimanic Agents; D014150:Antipsychotic Agents; D014635:Valproic Acid