Simple cyclohexanediamine-derived primary amine thiourea catalyzed highly enantioselective conjugate addition of nitroalkanes to enones.
A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.
Mei
Kui
K
Department of Pharmaceutical Science, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, People's Republic of China.
Jin
Mei
M
Zhang
Shilei
S
Li
Ping
P
Liu
Wenjing
W
Chen
Xiaobei
X
Xue
Fei
F
Duan
Wenhu
W
Wang
Wei
W
D000473:Alkanes / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003514:Cyclohexylamines / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
D000473:Alkanes; D000588:Amines; D003514:Cyclohexylamines; D007659:Ketones; D009574:Nitro Compounds; C030435:1,2-cyclohexanediamine; D013890:Thiourea