title: Implications of cytokine gene polymorphisms on the orchestration of the immune response: lessons learned from oral diseases.
abstract: Over the past 10 years, a plethora of information concerning the influence of gene polymorphisms on cytokine expression has been made available in the literature. Significant contribution to this field has come from studies of oral diseases, one of the widest spread health problems in the world, affecting hundreds of millions worldwide. Here we will discuss the importance of studies of gene polymorphism towards the identification of susceptible groups or prognostic indicators of oral disease. Additionally, we will highlight the differences in data obtained from genetically diverse populations and review the application of cytokine gene polymorphisms studies in oral diseases in autoimmune processes and parasitic infections.
authors.affiliation: Laboratory of Cell-Cell Interactions, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, CEP 31270-901, Belo Horizonte-MG, Brazil. waldutra@gmail.com
authors.forename: Walderez O
authors.initials: WO
authors.lastname: Dutra
authors.forename: Paula R
authors.initials: PR
authors.lastname: Moreira
authors.forename: Paulo Eduardo A
authors.initials: PE
authors.lastname: Souza
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Gollob
authors.forename: Ricardo S
authors.initials: RS
authors.lastname: Gomez
mesh_terms: D016207:Cytokines / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007111:Immunity, Cellular; D008954:Models, Biological; D009059:Mouth Diseases / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D010510:Periodontal Diseases / Q000235:genetics / Q000276:immunology / Q000473:pathology; D011110:Polymorphism, Genetic
chemical_list: D016207:Cytokines