title: [Magnetcardiographic detection of abnormal intraventricular activation in patients with ischemic heart disease with and without tachycardia].
abstract: Fragmented and delayed activation of ventricular myocardium can cause malignant tachyarrhythmias. By detection of ventricular late potentials only a severely delayed depolarisation is registered, but not the intra QRS-activation. The aim of this study was to examine the complete phase of ventricular depolarisation, to detect and to quantify abnormal electrical activation by magnetocardiography and to estimate in a small group of patients with coronary heart disease the prognostic significance.In 26 healthy subjects, 32 patients after myocardial infarction without malignant ventricular arrhythmias and 10 patients with coronary heart disease and a history of sustained, monomorph ventricular tachycardia magnetocardiography was performed in a magnetically shielded room. To quantify the fragmentation of QRS a fragmentation-index (FI) was calculated. Besides signal averaged ECG, in patients with coronary heart disease cardiac catheterisation and in patients with arrhythmias electrophysiological testing was performed. The FI for the three groups was significantly different (p<0,005). The mean FI in the group of healthy subjects was 20,4+/-5,4, in the group of postinfarction-patients without arrhythmias 27+/-12,1 and in the group of patients with coronary heart disease and ventricular arrhythmias 49,5+/-17,9. Dichotomized at 36 the sensitivity was 80%, the specifity 93%, the positive predictive value was 66% and the negative predictive value 96%. The FI was correlated to the extent of regional wall-motion-irregularity and global ejection fraction.Analyzing late potentials, the values for sensitivity and positive predictive value were surprisingly low (20% and 50%, respectively). The specifity was 96%, the negative predictive value was 88%. Calculating the FI on the basis of electrical signals only an insufficient discrimination of the groups was possible.In the follow-up period of two years one post-infarctional patient was resusciated because of ventricular fibrillation. The FI of this patient was 17.One patient with coronary 3-vessel-disease and left ventricular ejection fraction of 50% died due to acute myocardial infarction, his FI was 39.
  
  
  CONCLUSIONS
  By means of magnetocardiography fragmented ventricular activation in patients with coronary heart disease was demonstrated even within the QRS-complex and could be correlated to ventricular tachyarrhythmias.
authors.affiliation: Medizinische Klinik II Kardiologie und Pulmologie, Universitätsklinikum Bejamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12200, Berlin.
authors.forename: M
authors.initials: M
authors.lastname: Oeff
authors.forename: P
authors.initials: P
authors.lastname: Gödde
authors.forename: R
authors.initials: R
authors.lastname: Agrawal
authors.forename: P
authors.initials: P
authors.lastname: Endt
authors.forename: L
authors.initials: L
authors.lastname: Trahms
authors.forename: H P
authors.initials: HP
authors.lastname: Schultheiss