title: Gastroprotective constituents of Salvia officinalis L.
abstract: The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H(+),K(+)-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE.
authors.affiliation: Departamento de Farmacologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Mayer
authors.forename: Cristiane Hatsuko
authors.initials: CH
authors.lastname: Baggio
authors.forename: Cristina Setim
authors.initials: CS
authors.lastname: Freitas
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: dos Santos
authors.forename: André
authors.initials: A
authors.lastname: Twardowschy
authors.forename: Heros
authors.initials: H
authors.lastname: Horst
authors.forename: Moacir Geraldo
authors.initials: MG
authors.lastname: Pizzolatti
authors.forename: Gustavo Amadeu
authors.initials: GA
authors.lastname: Micke
authors.forename: Melina
authors.initials: M
authors.lastname: Heller
authors.forename: Elide Pereira
authors.initials: EP
authors.lastname: dos Santos
authors.forename: Michel Fleith
authors.initials: MF
authors.lastname: Otuki
authors.forename: Maria Consuelo Andrade
authors.initials: MC
authors.lastname: Marques
mesh_terms: D045784:Abietanes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000431:Ethanol; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D054328:Proton Pump Inhibitors; D051381:Rats; D017208:Rats, Wistar; D027543:Salvia officinalis / Q000737:chemistry*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D045784:Abietanes; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D054328:Proton Pump Inhibitors; D000431:Ethanol; C068623:carnosol; D019342:Acetic Acid