title: Effects of the driving condition of a pneumatic ventricular assist device on the cavitation intensity of the inlet and outlet mechanical heart valves.
abstract: Our group is currently developing a pneumatic ventricular assist device (PVAD), and in previous studies, we reported the mechanical heart valve (MHV) cavitation intensity at the inlet valve in the PVAD only. In this study, we investigated the effect of the running conditions on the cavitation intensity both for the inlet and outlet valve in the PVAD using an acoustic signal. A 23-mm Medtronic Hall valve with an opening angle of 70 degrees was mounted in the inlet and outlet port of the PVAD after removing the sewing ring. A mini pressure sensor with high frequency was mounted 15 mm downstream from the inlet valve and downstream from the outlet valve. The pressure signal was band-pass filtered between 35 and 500 kHz using a digital filter. The band-pass filtered root mean squared (RMS) pressure was used as an index of the cavitation intensity. The RMS pressure of the inlet valve was higher than that of the outlet valve. Even if the outlet valve has a lower RMS pressure than the inlet valve, cavitation occurs. In case of a full-filling and full-ejection condition, the RMS pressure of the inlet valve was higher than that of the partial-filling and partial-ejection condition. This means that a partial-filling and partial-ejection condition is best to prevent the hemolysis caused by the cavitation phenomenon and the damage to the valve surface in our PVAD system.
authors.affiliation: Department of Artificial Organs, Research Institute, National Cardiovascular Center, Suita, Osaka, Japan. hslee@ri.ncvc.go.jp
authors.forename: Hwansung
authors.initials: H
authors.lastname: Lee
authors.forename: Eisuke
authors.initials: E
authors.lastname: Tatsumi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Taenaka
mesh_terms: D001783:Blood Flow Velocity; D001831:Body Temperature; D004867:Equipment Design; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006353:Heart-Assist Devices; D006461:Hemolysis; D018056:Hemorheology; D006801:Humans; D008955:Models, Cardiovascular; D011312:Pressure; D011474:Prosthesis Design / Q000379:methods*; D011673:Pulsatile Flow; D012212:Rheology