title: Rhabdomyosarcoma arising in a mature cystic teratoma with contralateral serous carcinoma: case report and review of the literature.
abstract: Malignant transformation of a mature cystic teratoma of the ovary is rare, and occurs in approximately 2% of all cases. The most common malignancy arising in mature cystic teratoma is squamous cell carcinoma. Sarcomas very rarely develop in mature cystic teratoma. We describe the case of a 65-year-old patient with mature cystic teratoma, and with rhabdomyosarcomatous transformation and contralateral serous carcinoma. To our knowledge, this is the first case of a pure rhabdomyosarcoma arising in a mature cystic teratoma. The clinicopathologic and immunohistochemical findings of this exceptional case are reported and the literature is reviewed.
authors.affiliation: Department of Pathology, Medical School, Ondokuz Mayis University, Samsun, Turkey. mehmetkefeli@gmail.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kefeli
authors.forename: Bedri
authors.initials: B
authors.lastname: Kandemir
authors.forename: Ilkser
authors.initials: I
authors.lastname: Akpolat
authors.forename: Arzu
authors.initials: A
authors.lastname: Yildirim
authors.forename: Arif
authors.initials: A
authors.lastname: Kokcu
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007150:Immunohistochemistry; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D013724:Teratoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents