Topical cyclosporin A and mitomycin C injection as adjunctive therapy for prevention of primary pterygium recurrence.
The authors evaluated the results of topical cyclosporin A 1% and injected mitomycin C 0.01% use as adjunctive therapy for prevention of primary pterygium recurrence.



Eighty eyes of 76 consecutive patients who had pterygium excision surgery in a prospective, interventional clinical trial received conjunctival autografting combined with an immediate postoperative 0.1-cc injection of 0.01% mitomycin C in caruncula were randomized into two groups: those who received postoperative topical application of cyclosporin A and those who did not.



The recurrence rate in patients who received topical application of postoperative cyclosporin A was 7.5% (3 of 40) compared with 17.5% (7 of 40) for patients who did not receive topical application of postoperative cyclosporin A (P = .31). An unexpected and significant finding in women was that those who received cyclosporin A had no recurrences (0 of 26), whereas those who did not receive cyclosporin A did (6 of 25; 24%) (P = .03).



Intracaruncular mitomycin C 0.01% and topical cyclosporin A 1% combined with conjunctival autograft is useful in reducing pterygium recurrence.
Ibáñez
Miguela
M
Centro Médico Puerta de Hierro, Guadalajara, Mexico. drmaibanez@prodigy.net.mx
Eugarrios
Marcela F
MF
Calderón
Delmy I
DI
D000287:Administration, Topical; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000637:transplantation; D016572:Cyclosporine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007267:Injections; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D013508:Ophthalmologic Surgical Procedures; D011446:Prospective Studies; D011625:Pterygium / Q000517:prevention & control* / Q000601:surgery; D055502:Secondary Prevention; D014182:Transplantation, Autologous
D000903:Antibiotics, Antineoplastic; D007166:Immunosuppressive Agents; D016685:Mitomycin; D016572:Cyclosporine