[Clinical aspect of recent progress in phosphate metabolism. Bone as an endocrine organ].
FGF23, secreted by bone, inhibits renal phosphate reabsorption. Recently, it was reported that osteocalcin, secreted by bone, promotes adiponectin and insulin secretion and improves glucose metabolism. Thus, bone does not just work for a storage of calcium or resisting against gravity but an endocrine organ to affect other tissues.
Kimura
Ayako
A
Department of Orthpedics, Tokyo Medical and Dental University graduate school.
Takeda
Shu
S
D052242:Adiponectin / Q000378:metabolism; D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D004703:Endocrine System; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007668:Kidney / Q000378:metabolism; D015675:Osteocalcin / Q000378:metabolism / Q000502:physiology; D010710:Phosphates / Q000378:metabolism
D052242:Adiponectin; C000717427:FGF23 protein, human; D007328:Insulin; D010710:Phosphates; D015675:Osteocalcin; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005947:Glucose