Can we prevent diabetic birth defects with micronutrients?
Congenital malformations are more common in infants of diabetic women than in children of non-diabetic women. The mechanisms behind diabetes-induced congenital anomalies are not known. Disturbed micronutrient metabolism, in concert with oxidative stress, has been suggested as a cause of diabetes-induced malformations by several studies. In experimental work, administration of inositol, arachidonic acid and several antioxidative compounds, as well as folic acid, to the embryo, has proven to attenuate the teratogenic effects of a diabetic environment. Future therapeutic efforts may include supplementation with antioxidants or micronutrients, such as folic acid, to the pregnant diabetic woman, although exact compounds and doses need to be determined.
Wentzel
Parri
P
Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden. parri.wentzel@mcb.uu.se
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D016718:Arachidonic Acid / Q000008:administration & dosage; D000013:Congenital Abnormalities / Q000209:etiology / Q000517:prevention & control*; D019587:Dietary Supplements; D005260:Female; D047109:Fetal Development / Q000187:drug effects / Q000502:physiology; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D007294:Inositol / Q000008:administration & dosage*; D018977:Micronutrients / Q000008:administration & dosage* / Q000494:pharmacology; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology; D051381:Rats
D000975:Antioxidants; D018977:Micronutrients; D016718:Arachidonic Acid; D007294:Inositol; D005492:Folic Acid