First evidence for an anxiolytic effect of a diterpenoid from Salvia cinnabarina.
The potential anxiolytic and anti-depressive activity of CMP1 was studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMP1 on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMP1, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina.
Maione
Francesco
F
Department of Experimental Pharmacology, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.
Bonito
Maria Camela
MC
Colucci
Mariantonella
M
Cozzolino
Virginia
V
Bisio
Angela
A
Romussi
Giovanni
G
Cicala
Carla
C
Pieretti
Stefano
S
Mascolo
Nicola
N
D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D027544:Salvia / Q000737:chemistry*
C423882:3,4-secoisopimara-4(18),7,15-triene-3-oic acid; D014151:Anti-Anxiety Agents; D004224:Diterpenes