title: Antiviral evaluation of N-amino-1,2,3-triazoles against Cantagalo virus replication in cell culture.
abstract: This paper describes the antiviral evaluation of new N-amino-1,2,3-triazole derivatives, 1-(substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid ethyl esters, 3 and 1-(4-substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazides, 4, on Cantagalo virus replication. 1-(4-Fluoro-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazide, 4e, exhibited a significant antiviral effect. Characterization of all compounds was confirmed by IR, (1)H and (13)C spectroscopies and elemental analysis. In addition, molecular structure of 4e was also reported.
authors.affiliation: Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Quiímica, Outeiro de São João Baptista, 24020-141 Niterói, RJ, Brazil.
authors.forename: Alessandro K
authors.initials: AK
authors.lastname: Jordão
authors.forename: Priscila P
authors.initials: PP
authors.lastname: Afonso
authors.forename: Vitor F
authors.initials: VF
authors.lastname: Ferreira
authors.forename: Maria C B V
authors.initials: MC
authors.lastname: de Souza
authors.forename: Maria C B
authors.initials: MC
authors.lastname: Almeida
authors.forename: Cristiana O
authors.initials: CO
authors.lastname: Beltrame
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Paiva
authors.forename: Solange M S V
authors.initials: SM
authors.lastname: Wardell
authors.forename: James L
authors.initials: JL
authors.lastname: Wardell
authors.forename: Edward R T
authors.initials: ER
authors.lastname: Tiekink
authors.forename: Clarissa R
authors.initials: CR
authors.lastname: Damaso
authors.forename: Anna C
authors.initials: AC
authors.lastname: Cunha
mesh_terms: D000640:Amitrole / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014616:Vaccinia virus / Q000187:drug effects*; D014764:Viral Proteins / Q000032:analysis / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins; D000640:Amitrole