The level of malondialdehyde-modified LDL and LDL immune complexes in patients with rheumatoid arthritis.
OBJECTIVE
To explore possible associations of malondialdehyde-modified low-density lipoprotein (MDA-LDL) and LDL-immune complexes (LDL-IC) with atherosclerosis in rheumatoid arthritis (RA).


METHODS
Plasma MDA-LDL, LDL-IC levels and mechanisms of the changes were investigated in RA patients with or without coronary artery disease (CAD), simple CAD patients and control.


RESULTS
MDA-LDL and LDL-IC levels were found increased in all the studied patients, the RA patients with CAD exhibited the most significant changes. MDA-LDL levels were higher in the RA patients with CAD than those both in the simple RA and CAD patients. Multiple linear regression analysis showed that CAD, LDL-IC and erythrocyte sedimentation rate accounted for 36.5% of the variation in MDA-LDL levels; and age, activity, MDA-LDL and rheumatoid factors accounted for 34.5% of the variation in LDL-IC.


CONCLUSIONS
High levels of MDA-LDL and LDL-IC are risk factors for increased risk of atherosclerosis in RA patients and are associated with inflammation.
Wang
Junjun
J
Department of Biochemistry, Jinling Hospital, Clinical School of Medical College, Nanjing University, 305#, East Zhong Shan Road, Nanjing, 210002, PR China. wangjj6@jlonline.com
Hu
Bing
B
Meng
Yang
Y
Zhang
Chunni
C
Li
Ke
K
Hui
Cai
C
D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood* / Q000737:chemistry; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016014:Linear Models; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry / Q000276:immunology; D008297:Male; D008315:Malondialdehyde / Q000097:blood* / Q000737:chemistry; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000097:blood
D000936:Antigen-Antibody Complex; D008077:Lipoproteins, LDL; D008315:Malondialdehyde; D002097:C-Reactive Protein; D012217:Rheumatoid Factor