title: Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones.
abstract: The fluoroquinolones are an important family of synthetic antimicrobial agents being clinically used over the past thirty years. In addition, some fluoroquinolones have been used in the development of anticancer drugs, and others have demonstrated anti-HIV activity. Furthermore, there has been some additional work investigating the effect of metal ions on biological activity. Aiming to obtain novel palladium(II) and platinum(II) complexes that exhibit biological activity, we have synthesized complexes using fluoroquinolones (ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin, and gatifloxacin) as ligands. The compounds were characterized using IR and NMR spectroscopy, thermogravimetric and elemental analyses. The complexes show activity against Mycobacterium tuberculosis strain H(37)Rv. The minimal inhibitory concentration (MIC) of the complexes was determined.
authors.affiliation: Departamento de Química, Universidade Federal de Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil.
authors.forename: Lígia Maria M
authors.initials: LM
authors.lastname: Vieira
authors.forename: Mauro V
authors.initials: MV
authors.lastname: de Almeida
authors.forename: Maria Cristina S
authors.initials: MC
authors.lastname: Lourenço
authors.forename: Flávio Augusto F M
authors.initials: FA
authors.lastname: Bezerra
authors.forename: Ana Paula S
authors.initials: AP
authors.lastname: Fontes
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D024841:Fluoroquinolones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010984:Platinum / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D024841:Fluoroquinolones; D009944:Organoplatinum Compounds; D010984:Platinum