No difference in clinical transplant outcomes for local and imported liver allografts.
In the United States, liver allograft allocation is strictly regulated. Local centers have the first option to accept a donor liver; this is followed by regional allocation for those donor livers not used locally and then by national allocation for those donor livers not accepted regionally. This study reviews the outcomes of all liver allografts used over 6 years (2001-2007) and evaluates initial and long-term function stratified by the geographic source of the donor liver allograft. The records for 845 consecutive deceased donor liver transplants at a single center were reviewed. The geographic origin of the allograft was recorded along with donor and graft characteristics to determine the probable reason for graft refusal. Within our local organ procurement organization, there is 1 liver transplant center, and within the region, there are 8 active centers. Early graft failure included any graft loss within 7 days of transplant, and initial function was measured with liver enzymes 30 days post-transplant. Graft survival and patient survival were evaluated with Kaplan-Meier and Cox survival modeling. Median follow-up was 43 months. The geographic distribution of organs included local organs (562, 66%), regionally imported organs (126, 15%), and nationally imported organs (157, 19%). There were no differences between the 3 groups in initial graft function, intraoperative death, or early graft loss. Survival curves for the 3 study groups demonstrated no difference in survival up to 5 years post-transplant. In conclusion, liver allografts rejected for use by a large number of transplant centers can still be successfully used without early graft function or long-term survival being affected.
Mangus
Richard S
RS
Clarian Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202-5250, USA. rmangus@iupui.edu
Fridell
Jonathan A
JA
Vianna
Rodrigo M
RM
Kwo
Paul Y
PY
Chestovich
Paul
P
Milgrom
Martin L
ML
Kazimi
Marwan
M
Hollinger
Edward F
EF
Read
Jay Thomas
JT
Tector
A Joseph
AJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008099:Liver / Q000201:enzymology / Q000502:physiology; D016031:Liver Transplantation / Q000401:mortality / Q000502:physiology / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012307:Risk Factors; D009927:Tissue and Organ Procurement / Q000331:legislation & jurisprudence / Q000379:methods* / Q000706:statistics & numerical data*; D014184:Transplantation, Homologous; D014481:United States; D055815:Young Adult