Smoothening the controversial role of hedgehog in hematopoiesis.
The role of multiple developmental signaling pathways in the regulation of hematopoiesis has been controversial. In this issue of Cell Stem Cell, two separate reports (Hofmann et al., 2009; Gao et al., 2009) examine whether the Hedgehog signaling pathway modulates normal adult hematopoietic stem cells and blood formation.
Merchant
Akil A
AA
Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Baltimore, MD 21231, USA.
Matsui
William
W
D001773:Blood Cells / Q000166:cytology; D053823:Hedgehog Proteins / Q000502:physiology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D015398:Signal Transduction
D053823:Hedgehog Proteins