title: Antiplasmodial and other constituents from four Indonesian Garcinia spp.
abstract: Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L., Garcinia cornea L. and Garcinia cymosa K. Schum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, beta-sitosterol-3-O-beta-D-glucoside and stigmasterol-3-O-beta-D-glucoside from the stem bark of G. griffithii; friedelin and 3beta-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (+/-)-morelloflavone, morelloflavone-7-O-beta-D-glucoside or fukugiside, the triterpene 3beta-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene beta-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity.
authors.affiliation: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University, Palembang, Indonesia.
authors.forename: Elfita
authors.initials: E
authors.lastname: Elfita
authors.forename: Muharni
authors.initials: M
authors.lastname: Muharni
authors.forename: Madyawati
authors.initials: M
authors.lastname: Latief
authors.forename: Darwati
authors.initials: D
authors.lastname: Darwati
authors.forename: Ari
authors.initials: A
authors.lastname: Widiyantoro
authors.forename: Supriyatna
authors.initials: S
authors.lastname: Supriyatna
authors.forename: Husein H
authors.initials: HH
authors.lastname: Bahti
authors.forename: Dachriyanus
authors.initials: D
authors.lastname: Dachriyanus
authors.forename: Paul
authors.initials: P
authors.lastname: Cos
authors.forename: Louis
authors.initials: L
authors.lastname: Maes
authors.forename: Kenne
authors.initials: K
authors.lastname: Foubert
authors.forename: Sandra
authors.initials: S
authors.lastname: Apers
authors.forename: Luc
authors.initials: L
authors.lastname: Pieters
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification; D029760:Garcinia / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007214:Indonesia; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013265:Stigmasterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C541852:1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone; D000962:Antimalarials; D000981:Antiprotozoal Agents; D001577:Benzophenones; D047309:Flavones; D005960:Glucosides; D012855:Sitosterols; D014315:Triterpenes; D044004:Xanthones; C541853:garcihombronane D; C515918:isoxanthochymol; C464587:stigmasterol glucoside; D007810:Lanosterol; D002392:Catechin; D013265:Stigmasterol; C011015:lyoniside