CTX-M-type beta-lactamase in Escherichia coli isolated from sick animals in Korea.
About 408 Escherichia coli were isolated from sick farm animals and pets during 2003-2006. Of these isolates, four strains showed resistance to third-generation cephalosporins. The bla(CTX-M-14) gene was encountered in three E. coli strains, each of which were isolated from two cows and a dog, respectively, and bla(CTX-M-15) was identified in an E. coli isolated from a pig. All bla(CTX-M) genes were found to be transferred. The pulsed-field gel electrophoresis pattern indicated that the CTX-M-type beta-lactamase-producing E. coli isolates were genetically diverse. This study shows the emergence of CTX-M-type beta-lactamase-producing E. coli in animals for the first time in Korea. Study results suggest the need for awareness and comprehensive monitoring of extended-spectrum beta-lactamases in animals because gene transfer can occur between animals as well as humans.
Lim
Suk-Kyung
SK
National Veterinary Research and Quarantine Service, Ministry of Agriculture and Forestry, Anyang, Kyonggido, Republic of Korea. imsk@nvrqs.go.kr
Lee
Hee-Soo
HS
Nam
Hyang-Mi
HM
Jung
Suk-Chan
SC
Bae
You-chan
YC
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002417:Cattle / Q000382:microbiology*; D002439:Cefotaxime / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D004285:Dogs / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology / Q000662:veterinary*; D007723:Korea; D008826:Microbial Sensitivity Tests; D013552:Swine / Q000382:microbiology*; D001618:beta-Lactamases / Q000235:genetics*
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D002442:Ceftazidime; C456080:beta-lactamase CTX-M-14; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases; D002439:Cefotaxime