Capillary electrophoresis platforms for DNA sequence analysis.
Commercial availability of multicapillary DNA sequencing instruments can significantly impact the existing paradigm in high-throughput DNA sequencing facilities, shifting the rate-limiting step away from the electrophoresis and detection step. These instruments, although novel and poorly understood, represent a significant capital investment.This review informs the reader about the state-of-the-art instruments, although capillary sequencers are in a state of almost constant flux, with improvements emerging rapidly.
Mardis
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Technology Development, Genome Sequencing Center, Washington University School of Medicine, St. Louis, MO 63108, USA. emardis@watson.wustl.edu