title: Use of single-pill combination therapy in the evolving paradigm of hypertension management.
abstract: The use of antihypertensive therapy is an evolving paradigm. Although blood pressure (BP) control rates remain low, there have been improvements that may be attributable in part to a recent shift in clinical guidelines that recognizes that most patients will require multiple drugs to reach BP goals and encourages clinicians to use combination therapy as first-line treatment in selected patients. Single-pill combinations of two complementary antihypertensive medications offer benefits beyond those of separate administration of the individual component agents, providing a simpler medication regimen that is effective and well tolerated while enhancing patient adherence to therapy. In the future, there may be single-pill combinations of three antihypertensive drugs to further enhance BP control rates.
authors.forename: David A
authors.initials: DA
authors.lastname: Calhoun
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D010349:Patient Compliance; D017410:Practice Guidelines as Topic
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations