Bringing H2AX into the angiogenesis family.
The cell's ability to sense and respond to DNA damage is critical to maintain homeostasis and prevent the development of cancer. Paradoxically, Economopoulou et al. recently reported that a DNA damage response protein, H2AX, promotes tumor growth and angiogenesis.
Rankin
Erinn B
EB
Department of Radiation Oncology, Division of Radiation and Cancer Biology, Center for Clinical Sciences Research, Stanford University, Stanford, CA 94303-5152, USA.
Giaccia
Amato J
AJ
Hammond
Ester M
EM
D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology; D004249:DNA Damage / Q000502:physiology*; D042783:Endothelial Cells / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D006657:Histones / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism*
C468783:H2AX protein, human; D006657:Histones