title: [Evaluation of insulin resistance in type 1 diabetes with euglycemic-hyperinsulinemic clamp].
abstract: OBJECTIVE
  To investigate insulin resistance in type 1 diabetes (T1DM) with euglycemic-hyperinsulinemic clamp.
  
  
  METHODS
  Eight cases of newly diagnosed T1DM and 8 cases of newly diagnosed type 2 diabetes (T2DM) were selected. Their insulin sensitivity index (ISI) was evaluated with euglycemic-hyperinsulinemic clamp after 2 week insulin intensive treatment and compared with that of 10 healthy volunteers (normal control group, NC group).
  
  
  RESULTS
  Age, BMI, fasting insulin (FIns), fasting C-peptide in the T1DM group were significantly lower than those in the NC group, while waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), TC, TG, LDL-C, HDL-C were not significantly different between the T1DM and NC groups. Age, BMI, WHR, FIns, fasting C-peptide, SBP, TC, TG in the T1DM group were significantly lower than those in the T2DM group. The ISI of the NC, T1DM and T2DM groups were 12. 83 +/- 1.09, 9.95 +/-0.50, 3.80 +/- 0.20, respectively. There was significant difference among the three groups (P < 0.05).
  
  
  CONCLUSIONS
  The ISI in T1DM was significantly lower than that in NC group, but higher than that in T2DM.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
authors.forename: Guo-chun
authors.initials: GC
authors.lastname: Luo
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liang
authors.forename: Qing-hong
authors.initials: QH
authors.lastname: Hu
authors.forename: De-wen
authors.initials: DW
authors.lastname: Yan
authors.forename: Ling-bo
authors.initials: LB
authors.lastname: Lü
authors.forename: Wen-hui
authors.initials: WH
authors.lastname: Gu
authors.forename: Ze-long
authors.initials: ZL
authors.lastname: Chen
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Li
authors.forename: Ming-ming
authors.initials: MM
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin