title: Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositis.
abstract: OBJECTIVE
  The study aimed to investigate the effects of a combined functional and aerobic exercise program on aerobic capacity, muscle strength, and functional mobility in a group of patients with sporadic inclusion body myositis (IBM).
  
  
  METHODS
  Aerobic capacity, muscle strength, and functional capacity assessments were conducted on 7 participants with sporadic IBM before and after a 12-week exercise program, which included resistance exercises and aerobic stationary cycling 3 times per week on alternative days.
  
  
  RESULTS
  Aerobic capacity of the group increased significantly by 38%, and significant strength improvements were observed in 4 of the muscle groups tested (P < 0.05). The exercise program was well tolerated, and there was no significant change in the serum creatine kinase level after the exercise period.
  
  
  CONCLUSIONS
  An aerobic exercise program can be safely tolerated by patients with sporadic IBM and can improve aerobic capacity and muscle strength when combined with resistance training. These findings indicate that aerobic and functional muscle strengthening exercise should be considered in the management of patients with IBM.
authors.affiliation: Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Western Australia. ljohnson@meddent.uwa.edu.au
authors.forename: Liam G
authors.initials: LG
authors.lastname: Johnson
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Collier
authors.forename: Dylan J
authors.initials: DJ
authors.lastname: Edwards
authors.forename: Danielle L
authors.initials: DL
authors.lastname: Philippe
authors.forename: Peter R
authors.initials: PR
authors.lastname: Eastwood
authors.forename: Susan E
authors.initials: SE
authors.lastname: Walters
authors.forename: Gary W
authors.initials: GW
authors.lastname: Thickbroom
authors.forename: Frank L
authors.initials: FL
authors.lastname: Mastaglia
mesh_terms: D000368:Aged; D001642:Bicycling; D003401:Creatine / Q000097:blood; D005081:Exercise Therapy / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology; D018979:Myositis, Inclusion Body / Q000503:physiopathology* / Q000534:rehabilitation*; D010101:Oxygen Consumption / Q000502:physiology*; D004856:Postural Balance; D016896:Treatment Outcome
chemical_list: D003401:Creatine