Evaluation of insulin resistance and metabolic syndrome in patients with polycystic ovary syndrome.
OBJECTIVE
Polycystic ovary syndrome (PCOS) is associated with the clustering of states including insulin resistance (IR), obesity, elevated blood pressure, and dyslipidemia that are termed as metabolic syndrome (MBS). This study was designed to assess the differences between homeostatic model assessment (HOMA) values in PCOS and healthy women.


METHODS
In a case-control study, 55 women with PCOS and 59 women with normal cycles (control group) aged 15-40 years old were evaluated. In all the subjects (after obtaining written informed consent), blood pressure, body weight, height, body mass index (BMI), waist /hip ratio(WHR) and fasting blood glucose (FBG), triglycerides (TG), HDL, C-peptide, insulin, HOMA Index, and FGIR (fasting glucose to insulin ratio) were measured.


RESULTS
In this study, the prevalence of MBS was significantly higher in PCOS group compared with the control group (p = 0.028). There were no significant differences in age, waist/hip ratio, fasting glucose, insulin, and C-peptide levels between patients with PCOS and control group. Furthermore, the prevalence of impaired fasting glucose (IFG) and the mean of HOMA and FGIR did not differ significantly between PCOS and control group.


CONCLUSIONS
Criteria of MBS are frequently present in young women with PCOS and may be more useful as a prognostic factor than IR indexes in this age group. We suggest evaluation of IR in older age women with PCOS.
Lankarani
Mahnaz
M
Endocrinology and metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Valizadeh
Neda
N
Heshmat
Ramin
R
Peimani
Maryam
M
Sohrabvand
Farnaz
F
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000503:physiopathology*; D015995:Prevalence; D011379:Prognosis; D049629:Waist-Hip Ratio; D055815:Young Adult