Autoantibodies involved in neuropsychiatric manifestations associated with systemic lupus erythematosus.
In the course of Systemic Lupus Erythematosus (SLE), a variety of neuropsychiatric disturbances is reported with a prevalence ranging from 17% to 75%. The diagnosis of these syndromes is difficult and requires a careful psychiatric evaluation. Distinct autoantibodies detectable in serum or cerebrospinal fluid of patients with SLE are associated with the presence of neuropsychiatric disorders. These autoantibodies may have a pathogenic relevance in neuropsychiatric SLE or they may be merely an epiphenomenon. This review describes the various autoantibodies reported to be associated with neuropsychiatric manifestations in SLE and discusses their possible role.
Colasanti
Tania
T
Department of Infectious, Parasitic and Immune-Mediated Diseases Istituto Superiore di Sanità, Rome, Italy.
Delunardo
Federica
F
Margutti
Paola
P
Vacirca
Davide
D
Piro
Ettore
E
Siracusano
Alessandra
A
Ortona
Elena
E
D017153:Antibodies, Anticardiolipin / Q000502:physiology; D000974:Antibodies, Antinuclear / Q000502:physiology; D001323:Autoantibodies / Q000502:physiology*; D042783:Endothelial Cells / Q000276:immunology; D005732:Gangliosides / Q000276:immunology; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000523:psychology; D001523:Mental Disorders / Q000209:etiology*; D008869:Microtubule-Associated Proteins / Q000276:immunology; D009474:Neurons / Q000276:immunology; D010744:Phosphoric Monoester Hydrolases / Q000276:immunology; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology; D012270:Ribosomes / Q000276:immunology
D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D005732:Gangliosides; D005904:Glial Fibrillary Acidic Protein; D008869:Microtubule-Associated Proteins; D016194:Receptors, N-Methyl-D-Aspartate; C035356:SS-A antibodies; D010744:Phosphoric Monoester Hydrolases