Improvement of water solubility and in vitro dissolution rate of aceclofenac by complexation with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.
The present study deals with the inclusion complexation of aceclofenac with beta-cyclodextrin by grinding, microwave and spray-drying techniques. A derivative of beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin, was also subjected to the complexation process with aceclofenac by spray-drying technique. The samples were subjected to in-vitro dissolution studies, fourier transform infra-red spectroscopy, differential scanning calorimetry, nuclear magnetic resonance spectroscopy and x-ray diffraction studies. The in-vitro dissolution of aceclofenac-hydroxypropyl-beta-cyclodextrin complex was faster as compared to the aceclofenac- beta-cyclodextrin complex and aceclofenac alone. Spray-dried aceclofenac-beta-cyclodextrin complex were subjected to anti-inflammatory and analgesic activity and showed significant anti-inflammatory and analgesic activity.
Ranpise
Nisharani S
NS
Department of Pharmaceutics, Sinhgad College of Pharmacy, Pune-411041, Maharashtra, India. nisha_ranpise@yahoo.com
Kulkarni
Nilesh S
NS
Mair
Parth D
PD
Ranade
Arati N
AN
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D033362:Powder Diffraction; D051381:Rats; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D047392:beta-Cyclodextrins; D014867:Water; D004008:Diclofenac; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C031215:betadex; C056498:aceclofenac