title: Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population.
abstract: BACKGROUND
  The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been reported to associate with human longevity. However, little information is available in a Han Chinese longevity population.Therefore, we investigated the association of the ACE gene insertion/ deletion polymorphism with longevity in a Han Chinese population.
  
  
  METHODS
  We compared the distribution of ACE insertion/deletion genotype and allele frequencies in two groups: a longevity group (399 subjects) aged over 90 years and a control group (302 subjects) aged less than 60 years.
  
  
  RESULTS
  No difference in genotype and allele frequencies of the ACE gene insertion/deletion polymorphism was observed between the longevity group and the control group.When adjusting for gender, the difference between the longevity group and the control group was also not significant regarding the frequencies of the genotypes (male, p=0.994 and female, p=0.797) as well as allele frequencies (male, p=0.969 and female, p=0.884).
  
  
  CONCLUSIONS
  No association of the ACE gene insertion/deletion polymorphism with longevity was observed in our Han Chinese population.
authors.affiliation: Laboratory for Conservation and Utilisation of Bio-resource, Yunnan University, Kunming, China.
authors.forename: Jian-Kang
authors.initials: JK
authors.lastname: Yang
authors.forename: Yuan-Ying
authors.initials: YY
authors.lastname: Gong
authors.forename: Liang
authors.initials: L
authors.lastname: Xie
authors.forename: Shi-Gang
authors.initials: SG
authors.lastname: Lian
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.forename: Liang-You
authors.initials: LY
authors.lastname: Xu
authors.forename: Shou-Jun
authors.initials: SJ
authors.lastname: Gao
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Zhang
mesh_terms: D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A