Stimulatory effects of ferulic acid on endurance exercise capacity in mice.
Ferulic acid was orally administered to mice in order to investigate its effects on exercise endurance capacity. When a single administration of ferulic acid was given to the mice in an adjustable-current water pool, the duration of exhaustive swimming was longer than that exhibited by the mice in the control group. Also, when the mice were exhaustively exercised for 3 consecutive days, no change in swimming time was found in the ferulic acid-administered group on the final day, and a large decrease in the untreated mice. Administration of ferulic acid efficiently activated the hepatic antioxidative defense system during exercise. The mice that received ferulic acid showed significant increases in the activity of hepatic antioxidant enzymes such as superoxide dismutase, catalase, and glutathione-S-transferase. Furthermore, an increased glutathione level was observed, while the malondialdehyde content was reduced. These results suggest that ferulic acid possesses stimulatory effects that can enhance exercise endurance capacity and reduce fatigue by elevating antioxidative potentials.
You
Yanghee
Y
Department of Food and Nutrition, Chonnam National University, Gwangju, Korea.
Park
Jeongjin
J
Yoon
Ho-Geun
HG
Lee
Yoo-Hyun
YH
Hwang
Kwontack
K
Lee
Jeongmin
J
Kim
Kyungmi
K
Lee
Kwang-Won
KW
Shim
Sangin
S
Jun
Woojin
W
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003373:Coumaric Acids / Q000494:pharmacology*; D005221:Fatigue / Q000517:prevention & control; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010805:Physical Conditioning, Animal; D010807:Physical Endurance
D000975:Antioxidants; D003373:Coumaric Acids; D008315:Malondialdehyde; C004999:ferulic acid; D005978:Glutathione