title: Optical coherence tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation.
abstract: Enhanced tissue contrast in developmental biology specimens is demonstrated in vivo using a new type of spectroscopic optical coherence tomography analysis that is insensitive to spectroscopic noise sources. The technique is based on a statistical analysis of spectral modulation at each image pixel, and provides contrast based on both the intensity of the backscattered light and the distribution of scattering particle sizes. Since the technique does not analyze optical power at absolute wavelengths, it is insensitive to all spectroscopic noise that appears as local Doppler shifts. No exogenous contrast agents or dyes are required, and no additional components are needed to correct for reference arm motion.
authors.forename: Desmond
authors.initials: D
authors.lastname: Adler
authors.forename: Tony
authors.initials: T
authors.lastname: Ko
authors.forename: Paul
authors.initials: P
authors.lastname: Herz
authors.forename: James
authors.initials: J
authors.lastname: Fujimoto