Mariner transposons as genetic tools in vertebrate cells.
Transposable elements (TEs) are being investigated as potential molecular tools in genetic engineering, for use in procedures such as transgenesis and insertional mutagenesis. Naturally active and reconstructed active TEs are both being studied to develop non-viral delivery vehicles. To date, the active elements being used include three Mariner-Like Elements (MLEs). We review below the studies that have investigated the ability of these MLEs to insert a transgene in vertebrate cells.
Delaurière
L
L
EA2160 Mer Molécules Santé, équipe biologie moléculaire et génétique évolutive, Université du Maine, 72085 Le Mans, France.
Chénais
B
B
Hardivillier
Y
Y
Gauvry
L
L
Casse
N
N
D000818:Animals; D002477:Cells / Q000378:metabolism*; D004251:DNA Transposable Elements / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D018014:Gene Transfer Techniques; D006801:Humans; D019895:Transposases / Q000235:genetics*; D014714:Vertebrates / Q000235:genetics*
D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins; C111652:mariner transposases; D019895:Transposases