Allocation priority in non-urgent liver transplantation: An overview of proposed scoring systems.
Given the lack of donors, a correct organ allocation system for candidates to liver transplantation is essential to increase graft and patient survival. The most used organ allocation tools are Child-Turcotte-Pugh and model for end-stage liver disease. It is generally accepted that model for end-stage liver disease score is superior to the Child-Turcotte-Pugh classification in predicting the short-term survival of cirrhotic patients awaiting liver transplantation. Since 2002, model for end-stage liver disease is widely used for liver allocation. In recent years, to overcome limitations of the consolidated scores, some adjustments to the original model for end-stage liver disease formula and new scoring systems have been proposed. Published data suggest that integrating serum sodium and model for end-stage liver disease may improve the score prognostic accuracy but further studies are necessary to confirm this issue. The updated model for end-stage liver disease, obtained through a revision of traditional model for end-stage liver disease parameters and tested in a large cohort of patients, is of great interest at the moment. In conclusion, several scoring systems have been described for organ allocation, but today, none is definitely able to overcome the limitations of the Child-Turcotte-Pugh and model for end-stage liver disease systems.
Gitto
S
S
Department of Clinical Medicine, University of Bologna, Semeiotica Medica, Sant'Orsola-Malpighi Hospital, Bologna, Italy.
Lorenzini
S
S
Biselli
M
M
Conti
F
F
Andreone
P
P
Bernardi
M
M
D006801:Humans; D008099:Liver / Q000601:surgery; D017093:Liver Failure / Q000145:classification / Q000175:diagnosis* / Q000601:surgery; D016031:Liver Transplantation; D015233:Models, Statistical; D018579:Patient Selection; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012720:Severity of Illness Index; D009927:Tissue and Organ Procurement; D014850:Waiting Lists