Effect of oral sodium cromoglycate in 2 children with food-dependent exercise-induced anaphylaxis (FDEIA).
Food-dependent exercise-induced anaphylaxis (FDEIA) was prevented from recurring in 2 children by sodium cromoglycate (SCG) before intake of the causative food. CASE 1: A 14-year-old girl who had suffered recurrent symptoms of anaphylaxis when she exercised after lunch. Radioallergosorbent test (RAST) was 1.49 UA/mL for wheat. She was advised to take SCG before lunch. In 2007, she ate bread at lunchtime without taking SCG and developed anaphylaxis. After this, she always took SCG and did not develop anaphylaxis. CASE 2: A 9-year-old boy who had recurrent symptoms of anaphylaxis when he exercised after lunch. RAST was 0.46 UA/mL for wheat. He started taking SCG before lunch. In June 2008, he forgot to take SCG and ate fu (a food made from wheat). He exercised after lunch and developed anaphylaxis. Since then, he has always taken SCG and has not developed anaphylaxis.


CONCLUSIONS
Our findings suggest that SCG prevents FDEIA caused by wheat allergy.
Sugimura
Tetsu
T
Department of Pediatrics and Allergology, Sugimura Children's Medical Clinic, Chikugo, Japan. sugimura@kurume.ktarn.or.jp
Tananari
Yoshifumi
Y
Ozaki
Yukiko
Y
Maeno
Yasuki
Y
Ito
Shinichi
S
Yoshimoto
Yuno
Y
Kawano
Keiko
K
Tanaka
Seiji
S
D000284:Administration, Oral; D000293:Adolescent; D000485:Allergens; D000707:Anaphylaxis / Q000209:etiology / Q000517:prevention & control*; D002648:Child; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D011322:Primary Prevention / Q000379:methods; D011852:Radioallergosorbent Test; D018570:Risk Assessment; D012494:Sampling Studies; D055502:Secondary Prevention; D016896:Treatment Outcome
D000485:Allergens; D004205:Cromolyn Sodium