Comparative value of simple inflammatory markers in the prediction of left ventricular systolic dysfunction in postacute coronary syndrome patients.
OBJECTIVE
We sought to assess the comparative value of inflammatory markers on the occurrence of left ventricular systolic dysfunction (LVSD) after an acute coronary syndrome (ACS).


METHODS
During 2006-2008, 760 patients with an ACS were enrolled. C-reactive protein (CRP) and white blood cell (WBC) count were measured during the first 12 hours of hospital admission.


RESULTS
CRP levels and WBC count were significantly higher in those who developed LVSD compared to those who did not. The analysis revealed that a 10 mg/dL increase of CRP levels and a 1000/microL increase in WBC are associated with a 6% and a 7% increase in the likelihood of developing LVSD, respectively. Furthermore, WBC count at entry and CRP have almost the same predictive value for development of LVSD after an ACS (R(2) = 0.109 versus R(2) = 0.093).


CONCLUSIONS
Serum CRP levels and WBC count at entry are almost equally powerful independent predictors of LVSD, after an ACS.
Aggelopoulos
Panagiotis
P
First Cardiology Clinic, School of Medicine, University of Athens, 115 28 Athens, Greece. pagelop@gmail.com
Chrysohoou
Christina
C
Pitsavos
Christos
C
Papadimitriou
Lambros
L
Liontou
Catherine
C
Panagiotakos
Demosthenes
D
Tsiamis
Eleftherios
E
Stefanadis
Christodoulos
C
D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis*; D002097:C-Reactive Protein / Q000378:metabolism*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000378:metabolism*
D015415:Biomarkers; D002097:C-Reactive Protein