CD36 single nucleotide polymorphism is associated with variation in low-density lipoprotein-cholesterol in young Japanese men.
Macrophages uptake oxidized low-density lipoprotein (LDL) via a scavenger receptor such as CD36 from plasma, and then become foam cells. We examined the association of CD36 gene single nucleotide polymorphisms (SNPs) with certain metabolic characteristics in a young male Japanese population (n = 494). The G allele in a SNP located at +30215 on the 3'-untranslated region (UTR) was significantly correlated with the plasma LDL-cholesterol concentrations (r = 0.13, p <0.01). The difference in LDL-cholesterol concentrations was 10 mg dl(-1) between GG- and AA-genotype carriers (p <0.05). The CD36 gene SNP is a novel maker of the variation in the LDL-cholesterol levels in young Japanese men.
Morii
Toshiyuki
T
Department of Internal Medicine, Keio University, School of Medicine, Shinjuku-ku, Tokyo, Japan.
Ohno
Yoichi
Y
Kato
Norihiro
N
Hirose
Hiroshi
H
Kawabe
Hiroshi
H
Hirao
Keiichi
K
Eguchi
Takashi
T
Maruyama
Tatsuya
T
Hayashi
Matsuhiko
M
Saito
Ikuo
I
Yazaki
Yoshio
Y
Saruta
Takao
T
D044466:Asian People / Q000235:genetics; D018955:CD36 Antigens / Q000235:genetics*; D008078:Cholesterol, LDL / Q000097:blood*; D006801:Humans; D007564:Japan; D008297:Male; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
D018955:CD36 Antigens; D008078:Cholesterol, LDL