title: Ultrasound-mediated oxygen delivery from chitosan nanobubbles.
abstract: Ultrasound (US) energy combined with gas-filled microbubbles has been used for several years in medical imaging. This study investigated the ability of oxygen-loaded chitosan bubbles to exchange oxygen in the presence or in the absence of US. Oxygen delivery is enhanced by sonication and both frequency and time duration of US affected the exchange kinetics.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, 10125 Torino, Italy. roberta.cavalli@unito.it
authors.forename: Roberta
authors.initials: R
authors.lastname: Cavalli
authors.forename: Agnese
authors.initials: A
authors.lastname: Bisazza
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rolfo
authors.forename: Sonia
authors.initials: S
authors.lastname: Balbis
authors.forename: Daniele
authors.initials: D
authors.lastname: Madonnaripa
authors.forename: Isabella
authors.initials: I
authors.lastname: Caniggia
authors.forename: Caterina
authors.initials: C
authors.lastname: Guiot
mesh_terms: D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D045423:Microbubbles; D010100:Oxygen / Q000008:administration & dosage*; D013010:Sonication / Q000379:methods*; D013997:Time Factors; D014465:Ultrasonics
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D048271:Chitosan; D010100:Oxygen