Controlled iterative cross-coupling: on the way to the automation of organic synthesis.
Repetition does not hurt! New strategies for the modulation of the reactivity of difunctional building blocks are discussed, allowing the palladium-catalyzed controlled iterative cross-coupling and, thus, the efficient formation of complex molecules of defined size and structure (see scheme). As in peptide synthesis, this development will enable the automation of these reactions. M(PG)=protected metal, M(act)=metal.
Wang
Congyang
C
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany.
Glorius
Frank
F
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D010165:Palladium