title: Hospital admission for acute painful episode following methacholine challenge in an adolescent with sickle cell disease.
abstract: Asthma is associated with increases in sickle cell disease (SCD)-related morbidity and mortality. A thorough evaluation for asthma in children with SCD is important and may involve methacholine challenge (MCh). In this report, we present a 14-year-old male with SCD who was admitted for an acute painful episode following MCh. Pain events after MCh have not been previously reported in children with SCD. The risk-benefit ratio should be strongly considered prior to performance of MCh in this patient population, and all possible complications, including an acute painful episode, should be openly discussed with the parents and pediatric patient.
authors.affiliation: Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Knight-Perry
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Field
authors.forename: Michael R
authors.initials: MR
authors.lastname: Debaun
authors.forename: Janet
authors.initials: J
authors.lastname: Stocks
authors.forename: Jane
authors.initials: J
authors.lastname: Kirkby
authors.forename: Robert C
authors.initials: RC
authors.lastname: Strunk
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D001249:Asthma / Q000150:complications* / Q000175:diagnosis; D001985:Bronchial Provocation Tests / Q000009:adverse effects*; D016085:Bronchoconstrictor Agents / Q000009:adverse effects*; D002637:Chest Pain / Q000139:chemically induced*; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000009:adverse effects*
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride