title: Fetal growth and risk of childhood acute lymphoblastic leukemia: results from an Australian case-control study.
abstract: The relation between intrauterine growth and risk of childhood acute lymphoblastic leukemia was investigated in an Australian population-based case-control study that included 347 cases and 762 controls aged <15 years recruited from 2003 to 2006. Information on proportion of optimal birth weight, a measure of the appropriateness of fetal growth, was collected from mothers by questionnaire. Data were analyzed by using logistic regression. Risk of acute lymphoblastic leukemia was positively associated with proportion of optimal birth weight; the odds ratio for a 1-standard-deviation increase in proportion of optimal birth weight was 1.18 (95% confidence interval: 1.04, 1.35) after adjustment for the matching variables and potential confounders. This association was also present among children who did not have a high birth weight, suggesting that accelerated growth, rather than high birth weight per se, is associated with risk of acute lymphoblastic leukemia. Similar associations between proportion of optimal birth weight and acute lymphoblastic leukemia were observed for both sexes and across age groups and leukemia subtypes. Results of this study confirm earlier findings of a positive association between rapidity of fetal growth and subsequent risk of acute lymphoblastic leukemia in childhood, and they are consistent with a role for insulin-like growth factors in the causal pathway.
authors.affiliation: Centre for Child Health Research, Telethon Institute for Child Health Research, University of Western Australia, Perth, Western Australia, Australia. lizm@ichr.uwa.edu.au
authors.forename: E
authors.initials: E
authors.lastname: Milne
authors.forename: J A
authors.initials: JA
authors.lastname: Royle
authors.forename: N H
authors.initials: NH
authors.lastname: de Klerk
authors.forename: E
authors.initials: E
authors.lastname: Blair
authors.forename: H
authors.initials: H
authors.lastname: Bailey
authors.forename: C
authors.initials: C
authors.lastname: Cole
authors.forename: J
authors.initials: J
authors.lastname: Attia
authors.forename: R J
authors.initials: RJ
authors.lastname: Scott
authors.forename: B K
authors.initials: BK
authors.lastname: Armstrong
mesh_terms: D000293:Adolescent; D001315:Australia / Q000453:epidemiology; D001724:Birth Weight; D016022:Case-Control Studies; D016001:Confidence Intervals; D047109:Fetal Development; D005317:Fetal Growth Retardation; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D016015:Logistic Models; D016017:Odds Ratio; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000209:etiology; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D007334:Insulin-Like Growth Factor I