Bone health as a primary target in the pediatric age.
Bone tissue is constantly renewed during childhood and adolescence to assure skeleton growth both in size and mineral density: up to 90 percent of peak bone mass is acquired by age 18 in girls and age 20 in boys, which makes youth the best time to "invest" in bone health. The reduction in bone mineral density leading to compromised strength and microarchitecture of bone tissue can favour the occurrence of fragility fractures in the pediatric age. Assessing the normality of bone density measurements in childhood by current methods is hampered by the lack of normative control data. The understanding of factors useful for maximizing peak bone mass, as well as the knowledge of diagnostic tools and therapeutic strategies for managing a state of reduced bone mineral density are crucial to prevent fractures throughout lifetime.
Caradonna
P
P
Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Rigante
D
D
D000293:Adolescent; D000365:Age Determination by Skeleton; D000367:Age Factors; D015519:Bone Density / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult