Applications of supercritical fluid chromatography-tandem mass spectrometry in pharmaceuticals.
Supercritical fluid chromatography (SFC) is a fully mature technique and can readily be coupled to mass spectrometers relatively easily. In the last years, supercritical fluid chromatography coupled with mass spectrometry (SFC-MS) has had a great advance in productivity, due to increase in reliability and robustness of both SFC and MS systems, the need to push drug discovery faster, and as a potential solution to old problems unsolved and new problems yet to be encountered. This article will illustrate the role of SFC-MS analysis in drug discovery process.
Bosch
Maria Espinosa
ME
Department of Pharmacy, General Hospital, University Hospital Virgen del Rocío, Manuel Siurot S/n, 41013, Spain.
Sánchez
Antonin Jesús Ruiz
AJ
Rojas
Fuensanta Sánchez
FS
Ojeda
Catalina Bosch
CB
D002626:Chemistry, Pharmaceutical / Q000379:methods; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D057166:High-Throughput Screening Assays / Q000295:instrumentation; D004364:Pharmaceutical Preparations / Q000032:analysis; D013237:Stereoisomerism; D053719:Tandem Mass Spectrometry / Q000379:methods*; D013678:Technology, Pharmaceutical / Q000379:methods
D004364:Pharmaceutical Preparations