Enantioselective organocatalytic conjugate reduction of beta-azole-containing alpha,beta-unsaturated aldehydes.
Beta-azole-containing alpha,beta-unsaturated aldehydes were successfully reduced under highly enantioselective organocatalytic transfer hydrogenation conditions. The products were obtained in good yields and up to 94% optical purity. This simple process was successfully applied to the synthesis of the C7-C14 fragment of ulapualide A, a natural product which exhibits promising antitumor activity.
Hoffman
Thomas J
TJ
Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, F-75231 Paris Cedex 05, France.
Dash
Jyotirmayee
J
Rigby
James H
JH
Arseniyadis
Stellios
S
Cossy
Janine
J