title: Beta,beta-disubstituted C- and N-vinylindoles from one-step condensations of aldehydes and indole derivatives.
abstract: Direct preparation of beta,beta-disubstituted C- and N-vinylindoles from condensation of aldehydes on indole derivatives is presented. Heating 1-methyl- and 1-benzylindole 3a,b with alkyl and aryl alpha-branched aldehydes and TFA in acetonitrile using microwave irradiation furnished 3-vinylindoles 1a-e in 18-76% yields. Under similar conditions, 3-substituted indoles 4a-c provided N-vinylindoles 2a-h in 16-98% yields.
authors.affiliation: Département de chimie, Université de Montréal, C.P. 6128, Succursale Centre Ville, Montréal, Québec H3C 3J7, Canada.
authors.forename: Gil
authors.initials: G
authors.lastname: Fridkin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Boutard
authors.forename: William D
authors.initials: WD
authors.lastname: Lubell