title: Less is more: improved outcomes in surgical patients with conservative fluid administration and central venous catheter monitoring.
abstract: BACKGROUND
  The ARDS Clinical Trials Network Fluid and Catheter Treatment Trial (FACTT) addressed fluid management and central monitoring of patients with acute respiratory distress syndrome/acute lung injury (ARDS/ALI). Because surgical patients may have been fundamentally different from the overall FACTT cohort, we set out to separately analyze the surgery patients in the trial.
  
  
  METHODS
  We performed a posthoc, surgical subgroup analysis of 1,000 patients enrolled in the FACTT. Patients were randomized using a 2x2 factorial design comparing a conservative (CON) versus a liberal (LIB) strategy of fluid management and the use of a pulmonary artery catheter (PAC) or a central venous catheter (CVC). The primary end point was death at 60 days. Secondary end points included the number of ventilator-free days, ICU-free days, and dialysis-free days until hospital discharge up to day 90. We defined surgical patients as those admitted to a surgical ICU, burn ICU, or cardiac surgical ICU; trauma patients; or those with an APACHE III surgical admission type.
  
  
  RESULTS
  There were 244 surgical patients. Risk of death within 60 days of randomization did not vary with catheter or fluid management, and a corresponding lack of effect was evident with regard to dialysis-free days. Ventilator-free days were increased in the fluid-conservative group (LIB, 13+/-1 days; CON, 15+/-1 days; p=0.04) at 28 days. CVC patients had more ventilator-free days at 28 and 90 days (28 days: CVC, 16+/-1 days; PAC, 13+/-1 days; p=0.03; 90 days: CVC, 64+/-3 days; PAC, 57+/-4 days; p=0.03). CVC patients had more ICU-free days at 90 days (90 days: CVC, 63+/-3 days; PAC, 55+/-3 days; p=0.04).
  
  
  CONCLUSIONS
  The risk of death did not vary with fluid management or catheter. A conservative fluid-administration strategy and central venous catheter monitoring resulted in more ventilator-free and ICU-free days in surgical patients with acute lung injury, and conservative fluid administration did not result in more renal failure.
authors.affiliation: Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA.
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Stewart
authors.forename: Pauline K
authors.initials: PK
authors.lastname: Park
authors.forename: John P
authors.initials: JP
authors.lastname: Hunt
authors.forename: Robert C
authors.initials: RC
authors.lastname: McIntyre
authors.forename: Janet
authors.initials: J
authors.lastname: McCarthy
authors.forename: Lee Ann
authors.initials: LA
authors.lastname: Zarzabal
authors.forename: Joel E
authors.initials: JE
authors.lastname: Michalek
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D002405:Catheterization, Central Venous; D003422:Critical Care; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011184:Postoperative Period; D011651:Pulmonary Artery / Q000502:physiology; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000628:therapy*; D014882:Water-Electrolyte Balance
chemical_list: D004232:Diuretics