A critical process controlled by MalT and OmpR is revealed through synthetic lethality.
The death of cells harboring defects in two distinct pathways implicates these pathways in the control of an essential process. Here we report that cells lacking OmpR and harboring constitutively active MalT undergo premature death that involves increased expression of the outer membrane porin LamB.
Reimann
Sylvia A
SA
Department of Microbiology and Immunology, Loyola University Chicago, 2160 S. First Ave., Maywood, IL 60153, USA.
Wolfe
Alan J
AJ
D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000502:physiology; D000115:Acetylesterase / Q000235:genetics / Q000502:physiology; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000502:physiology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D003542:Cystathionine gamma-Lyase / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D018272:Porins / Q000235:genetics / Q000502:physiology; D011991:Receptors, Virus / Q000235:genetics / Q000502:physiology; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D018528:ATP-Binding Cassette Transporters; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C489398:MalK protein, E coli; C058976:MalT protein, E coli; D018272:Porins; D011991:Receptors, Virus; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C016532:maltoporins; C112177:osmolarity response regulator proteins; C079405:MalY protein, E coli; C115513:AES protein, E coli; D000115:Acetylesterase; D003542:Cystathionine gamma-Lyase