title: Effect of exogenous surfactant therapy on levels of pulmonary surfactant proteins A and D in preterm infants with respiratory distress syndrome.
abstract: OBJECTIVE
  To examine whether exogenous pulmonary surfactants (exPS) substitute for or merely supplement endogenous pulmonary surfactants (enPS) by looking at sequential changes in the surfactant proteins (SP) SP-A and SP-D in alveolar pools.
  
  
  METHODS
  Fourteen preterm infants with RDS treated with an artificial surfactant were compared to five normal-term infants without RDS who were treated with artificial ventilation at birth.
  
  
  RESULTS
  Immediately after birth, SP-A and SP-D were essentially absent in the alveolar pools of the RDS group, but were present at normal levels in the controls. Treatment with exPS apparently stimulated enPS production.
  
  
  CONCLUSIONS
  In infants who responded well to exPS therapy, the SP concentration reached essentially normal levels within 48-72 h after birth.
authors.affiliation: Department of Pediatrics, College of Medicine, Kyunghee University, Kangdong-Gu, Seoul, Korea.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Bae
authors.forename: Chong-Woo
authors.initials: CW
authors.lastname: Bae
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Oh
authors.forename: Sang Han
authors.initials: SH
authors.lastname: Lee
authors.forename: Kee Min
authors.initials: KM
authors.lastname: Woo
authors.forename: Keum Bun
authors.initials: KB
authors.lastname: Jung
mesh_terms: D000367:Age Factors; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016022:Case-Control Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D037662:Pulmonary Surfactant-Associated Protein A / Q000172:deficiency / Q000378:metabolism*; D037663:Pulmonary Surfactant-Associated Protein D / Q000172:deficiency / Q000378:metabolism*; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy* / Q000378:metabolism* / Q000628:therapy
chemical_list: D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants