S100B milk concentration in mammalian species.
S100B is a neurotrophic protein detectable in biological fluids and in human milk. Since there are several maternal-neonatal conditions requiring the administration of animal milks the aim of the present study was to quantify S100B in milk from different mammalian species and to compare protein's concentration among human and mammalian milks. We assessed S100B concentrations in donkey (n=12), goat (n=15) sheep (n=15), commercially available cow (n=8) and human (n=15) milk samples. S100B measurements were performed using an immunoluminometric assay. S100B concentration in human milk (10.41 +/- 4.2 microg/L) was higher (P LESS THAN0.001) than mammalian milks. Of note, S100B concentration in cow milk (3.13 +/- 0.56 microg/L) was higher (P LESS THAN0.01) than that showed in donkey (1.17 +/- 0.26 microg/L), sheep (0.25 +/- 0.11 microg/L) and goat (0.26 +/- 0.11 microg/L). S100B in donkey milk was higher (P LESS THAN0.01) than sheep and goat samples whilst protein's concentration did not differ between goat and sheep. The present study suggests the opportunity of S100B addition to animal milk intended for infant feeding.
Galvano
Fabio
F
Department of Biochemistry, Medical Chemistry and Molecular Biology, University of Catania, Italy.
Frigiola
Alessandro
A
Gagliardi
Luigi
L
Ciotti
Sabina
S
Bognanno
Matteo
M
Iacopino
Anna Maria
AM
Nigro
Francesco
F
Tina
Gabriella Lucia
GL
Cavallaro
Daniela
D
Mussap
Michele
M
Piva
Andrea
A
Grilli
Ester
E
Michetti
Fabrizio
F
Gazzolo
Diego
D
D000704:Analysis of Variance; D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D018397:Equidae; D006041:Goats; D006801:Humans; D007118:Immunoassay; D008892:Milk / Q000737:chemistry*; D008895:Milk, Human / Q000737:chemistry*; D009414:Nerve Growth Factors / Q000032:analysis*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis*; D012756:Sheep; D013045:Species Specificity
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human