title: [Nephrogenic systemic fibrosis: a severe complication of use to gadolinium in patients with kidney failure].
abstract: Nephrogenic systemic fibrosis (NSF), also known as nephrogenic fibrosing dermopathy (NFD), is a condition that has occurred only in patients with renal insufficiency. Besides lesions of the skin, this syndrome include fibrosis of skeletal muscle, joints, liver, lung, and heart, with possible fatal outcomes. This disease was first described in 1997 and several reports described the development of NSF after the exposure to gadolinium-based magnetic resonance imaging contrast agents. This review aims to alert physicians and nephrologists about this new pathology that affects patients with renal dysfunction, describing its demographic and epidemiologics aspects, clinic presentation, diagnosis and prognosis, beyond options to prevent and current treatment. We concluded that in all patient with elevated serum creatinine physicians should estimade his kidney function (creatinine clearence) in order to safety of magnetic resonance.
authors.affiliation: Hospital Municipal de São José dos Campos, SP.
authors.forename: Juliano Sacramento
authors.initials: JS
authors.lastname: Mundim
authors.forename: Sabrina de Castro
authors.initials: Sde C
authors.lastname: Lorena
authors.forename: Hugo
authors.initials: H
authors.lastname: Abensur
authors.forename: Rosilene Motta
authors.initials: RM
authors.lastname: Elias
authors.forename: Rosa Maria Affonso
authors.initials: RM
authors.lastname: Moysés
authors.forename: Manuel Carlos Martins de
authors.initials: MC
authors.lastname: Castro
authors.forename: João Egídio
authors.initials: JE
authors.lastname: Romão Júnior
mesh_terms: D003287:Contrast Media / Q000009:adverse effects* / Q000493:pharmacokinetics; D005682:Gadolinium / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D054989:Nephrogenic Fibrosing Dermopathy / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D051437:Renal Insufficiency / Q000473:pathology
chemical_list: D003287:Contrast Media; D005682:Gadolinium