title: [Selected indices of peritoneal fibrosis in patients undergoing peritoneal dialysis].
abstract: Peritoneal dialysis is an alternative to hemodialysis in the treatment of patients with end-stage renal disease. Long-term use of peritoneal dialysis is limited by progressive alterations in the peritoneal membrane. The pathological changes in the peritoneum are due to the exposure to traditional nonphysiological peritoneal dialysis fluids that have low pH, high glucose and glucose degradation product content, and high molarity. Repeated episodes of bacterial peritonitis are another cause of peritoneal membrane damage. The characteristic features of peritoneal alterations include peritoneal fibrosis and morphologic changes in the peritoneal microvasculature with the accumulation of extracellular matrix in the submesothelial area and loss of mesothelial cells.These changes in the peritoneal membrane cause ultrafiltration failure and loss of dialysis efficacy. The pathogenesis of the peritoneal membrane damage is very complicated and understanding the processes involved in these alterations will be crucial in improving treatment with peritoneal dialysis. Some points of view on fibrosis of peritoneal membrane in patients undergoing peritoneal dialysis are presented here.
authors.affiliation: Katedra i Klinika Nefrologii i Medycyny Transplantacyjnej Akademii Medycznej we Wrocławiu, 50-417 Wrocław. jpenar@interia.pl
authors.forename: Józef
authors.initials: J
authors.lastname: Penar
authors.forename: Wacław
authors.initials: W
authors.lastname: Weyde
authors.forename: Magdalena
authors.initials: M
authors.lastname: Krajewska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Madziarska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gołebiowski
authors.forename: Maciej
authors.initials: M
authors.lastname: Szymczak
authors.forename: Renata
authors.initials: R
authors.lastname: Kłak
authors.forename: Marian
authors.initials: M
authors.lastname: Klinger
mesh_terms: D004848:Epithelium / Q000378:metabolism* / Q000473:pathology*; D005355:Fibrosis / Q000209:etiology; D006801:Humans; D009389:Neovascularization, Pathologic; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000098:blood supply* / Q000473:pathology*