title: Can laboratory tests predict the prognosis of patients after endovascular aneurysm repair? Current status and future directions.
abstract: The purpose of this study was to determine what laboratory values predict the prognosis of patients after endovascular aneurysm repair (EVAR). MEDLINE and Cochrane Library databases were searched. This resulted in 13 relevant articles. Data were pooled, and meta-analyses were performed. A meta-analysis including 5,655 patients showed that preoperative serum creatinine>1.5 mg/dL was a significant risk indicator for increased 30-day mortality (relative risk 3.0, 95% confidence interval 2.3-4.1, p<.0001). Four other studies showed that other cutoff values of creatinine or glomerular filtration rate can predict mortality and complications following EVAR. One study suggested that reduced preoperative hemoglobin is a risk indicator for reduced long-term survival. Increased serum creatinine, reduced glomerular filtration rate, and reduced hemoglobin are significant and strong predictors of mortality and complications after EVAR. Current evidence remains limited, and further research is needed to determine conclusively additional laboratory values that may predict the outcome of patients following EVAR.
authors.affiliation: Department of Surgery, Yale University School of Medicine, New Haven, CT 06519, USA.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Huddle
authors.forename: Felix J V
authors.initials: FJ
authors.lastname: Schlösser
authors.forename: Michael C
authors.initials: MC
authors.lastname: Dewan
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Indes
authors.forename: Bart E
authors.initials: BE
authors.lastname: Muhs
mesh_terms: D001011:Aorta / Q000601:surgery*; D001014:Aortic Aneurysm / Q000097:blood / Q000401:mortality / Q000601:surgery*; D001019:Aortic Rupture / Q000097:blood / Q000401:mortality / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D019060:Minimally Invasive Surgical Procedures; D009017:Morbidity; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D003404:Creatinine