title: Clinical observations of cattle and buffalos with experimentally induced chronic copper poisoning.
abstract: The susceptibility of cattle and buffalos to chronic copper poisoning (CCP) was compared by using cattle (n=10) and buffalo (n=10) steers distributed into two copper supplemented (n=6) and two control (n=4) groups. Supplemented animals received 2 mg copper (Cu)/kg body weight daily for one week, with an additional 2 mg weekly until the end of the experiment (day 105). Three liver biopsies (day 0, 45, and 105) were obtained for mineral analyses; clinical examinations and blood samples were obtained every 15days. Three supplemented cattle and two buffalos with typical manifestations of CCP died. There were no differences in the frequency of mortality between cattle and buffalos; hepatic copper concentration was higher in cattle than buffalos. These findings suggest that buffalos and cattle might be equally susceptible to CCP. However, buffalos accumulate less liver copper than cattle and have a lower threshold of hepatic Cu accumulation, which leads to clinical manifestation of CCP.
authors.affiliation: Department of Clinical Science, College of Veterinary Medicine, University of Sao Paulo, USP, São Paulo, SP, Brazil.
authors.forename: Antonio H H
authors.initials: AH
authors.lastname: Minervino
authors.forename: Raimundo A
authors.initials: RA
authors.lastname: Barrêto Júnior
authors.forename: Rodrigo N F
authors.initials: RN
authors.lastname: Ferreira
authors.forename: Frederico A M L
authors.initials: FA
authors.lastname: Rodrigues
authors.forename: Selwyn A
authors.initials: SA
authors.lastname: Headley
authors.forename: Clara S
authors.initials: CS
authors.lastname: Mori
authors.forename: Enrico L
authors.initials: EL
authors.lastname: Ortolani
mesh_terms: D000818:Animals; D002020:Buffaloes; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced* / Q000401:mortality; D002908:Chronic Disease; D003300:Copper / Q000506:poisoning*; D008099:Liver / Q000378:metabolism; D008297:Male; D011041:Poisoning / Q000662:veterinary; D013045:Species Specificity; D015032:Zinc
chemical_list: D003300:Copper; D015032:Zinc