title: [Preparation and drug releasing property of curcumin nanoparticles].
abstract: OBJECTIVE
  To prepare curcumin nanoparticles and evaluate the in vitro release of curcumin.
  
  
  METHODS
  The chitosan-graft-vinyl acetate copolymers were synthesized by free radical polymerization. Curcumin nanoparticles were synthesized by ultrasonic irradiation. The encapsulation efficiency of the nanoparticles and the in vitro release of curcumin were studied.
  
  
  RESULTS
  The nanoparticles were discrete and uniform spheres, covered with positive charges. The encapsulation efficiency of nanoparticles was up to 91.6%. The in vitro release profile showed the slower release rate of curcumin.
  
  
  CONCLUSIONS
  The methods is simple. The nanoparticles possess good physical performance and sustained release character in vitro.
authors.affiliation: School of Science, Tianjin University, Tianjin 300072, China. liuzhanjun815@163.com
authors.forename: Zhan-jun
authors.initials: ZJ
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Han
authors.forename: Jiu-gao
authors.initials: JG
authors.lastname: Yu
authors.forename: Hong-guang
authors.initials: HG
authors.lastname: Dai
mesh_terms: D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000302:isolation & purification*; D016503:Drug Delivery Systems; D053758:Nanoparticles / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D014465:Ultrasonics
chemical_list: D011108:Polymers; D048271:Chitosan; D003474:Curcumin