Serial changes in oxidized low-density lipoprotein associated with culprit vessel in ST-elevation myocardial infarction--a promising marker?
The aim of the present study was to investigate variations in oxidized LDL (oxLDL) at the onset of acute myocardial infarction (AMI) and over the recovery period, exploring their relationship with coronary disease severity. A follow-up of 50 AMI patients was evaluated against 25 healthy volunteers (reference group). The AMI patients were evaluated at three time points: at admission before the administration of IIb/IIIa inhibitors and angioplasty, and two and 40 days after intervention. Plasma oxLDL concentrations were measured by ELISA. oxLDL was found to be significantly higher in AMI patients in the acute phase relative to reference levels, decreasing progressively over the recovery period. The results also demonstrated that oxLDL levels were decreased in patients with the left circumflex artery (LCX) as culprit vessel compared to the left anterior descending coronary (LAD) or right coronary artery (RCA). The results highlight a significant increase in oxLDL concentration related to coronary artery disease severity, as conditions such as LCX lesions are usually associated with a favorable prognosis, contrasting with LAD-associated conditions that can compromise large areas of myocardium. The results thus suggest that oxLDL may constitute a promising marker in assessment of AMI evolution.
Napoleão
Patrícia
P
Centro de Biologia Ambiental, Universidade de Lisboa, Lisboa, Portugal. pnapoleao@itn.pt
Selas
Mafalda
M
Toste
Alexandra
A
Turkman
Antónia
A
Andreozzi
Valeska
V
Viegas-Crespo
Ana Maria
AM
Pinheiro
Teresa
T
Ferreira
Rui Cruz
RC
D000328:Adult; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000209:etiology / Q000503:physiopathology*
D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein