title: [Cellulase treatment in 3 cases of large phytobezoars].
abstract: BACKGROUND
  A bezoar is a hard mass of undigested foreign matter found in the gastrointestinal system. The most common type is the phytobezoar, which is composed of vegetable fibres. There is no current consensus as to its treatment. Three cases of phytobezoars treated with cellulase are described.
  
  
  METHODS
  Case 1: patient with large gastric phytobezoar. Initial treatment with nasogastric cola drink lavages was ineffective. Subsequent treatment with cellulase was successful. Case 2: patient with gastric phytobezoar who was treated with cellulase and metoclopramide. Definitive fragmentation was performed with the endoscopy technique. Case 3: patient with large intestinal phytobezoar. The patient was treated by endoscopic lysis with partial success. Subsequent treatment with cellulase led to complete disintegration. In all the cases, cellulase was administered in pure form by nasogastric tube, and none of the patients suffered adverse effects.
  
  
  CONCLUSIONS
  Treatment with cellulase is based on the enzymatic degradation of the bezoar. It has been shown to be effective as the treatment of choice in earlier studies with few patients. This agent seems to be a good alternative for patients with large phytobezoars.
authors.affiliation: Servicio de Farmacia, Hospital del Mar (IMAS), Barcelona, España. 96736@imas.imim.es
authors.forename: J
authors.initials: J
authors.lastname: Fernández Morató
authors.forename: L
authors.initials: L
authors.lastname: Ilzarbe Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Bessa Caserras
authors.forename: J
authors.initials: J
authors.lastname: Mateu de Antonio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001630:Bezoars / Q000188:drug therapy* / Q000473:pathology; D002480:Cellulase / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D002480:Cellulase