Prognostic significance of bioelectrical impedance phase angle in advanced cancer: preliminary observations.
Bioelectrical impedance-derived phase angle is a potentially sensible indicator of protein-energy malnutrition and of fat-free mass loss, frequent in patients with advanced cancer. We evaluated in 13 patients with advanced cancer some biochemical (serum albumin, lymphocyte count, cholesterol, cholinesterase) and clinical (Karnofsky index, Subjective Global Assessment, dietary inquiry) parameters and bioelectrical impedance analysis was performed. In addition to albumin, cholinesterase, and the Karnofsky index, phase angle (R(2)=0.384, P=0.024) was found to be strictly related to survival time and can be therefore considered a prognostic tool in patients with advanced cancer.
Santarpia
Lidia
L
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. nad2005@unina.it
Marra
Maurizio
M
Montagnese
Concetta
C
Alfonsi
Lucia
L
Pasanisi
Fabrizio
F
Contaldo
Franco
F
D000368:Aged; D001823:Body Composition; D002462:Cell Membrane; D002470:Cell Survival / Q000502:physiology*; D002802:Cholinesterases / Q000097:blood; D017097:Electric Impedance; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis / Q000401:mortality; D011379:Prognosis; D016016:Proportional Hazards Models; D011502:Protein-Energy Malnutrition / Q000175:diagnosis*; D012709:Serum Albumin; D015431:Weight Loss
D012709:Serum Albumin; D002802:Cholinesterases