Coccidioides immitis meningitis in a patient with hyperimmunoglobulin E syndrome due to a novel mutation in signal transducer and activator of transcription.
Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency characterized by recurrent skin and lung infections. We report the first case of Coccidioides immitis meningitis in a patient with HIES. Coccidioides should be included in the differential diagnosis for central nervous system infections in HIES patients.
Powers
Annie E
AE
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA. annie.eisinger@hsc.utah.edu
Bender
Jeffrey M
JM
Kumánovics
Attila
A
Ampofo
Krow
K
Augustine
Nancy
N
Pavia
Andrew T
AT
Hill
Harry R
HR
D000293:Adolescent; D019943:Amino Acid Substitution / Q000235:genetics; D000666:Amphotericin B / Q000627:therapeutic use; D000908:Antibodies, Fungal / Q000134:cerebrospinal fluid; D000935:Antifungal Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003045:Coccidioides / Q000302:isolation & purification*; D003047:Coccidioidomycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007589:Job Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016921:Meningitis, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D020125:Mutation, Missense; D050796:STAT3 Transcription Factor / Q000235:genetics*; D017422:Sequence Analysis, DNA
D000908:Antibodies, Fungal; D000935:Antifungal Agents; D007074:Immunoglobulin G; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D000666:Amphotericin B