[Evaluation of insulin resistance in type 1 diabetes with euglycemic-hyperinsulinemic clamp].
OBJECTIVE
To investigate insulin resistance in type 1 diabetes (T1DM) with euglycemic-hyperinsulinemic clamp.


METHODS
Eight cases of newly diagnosed T1DM and 8 cases of newly diagnosed type 2 diabetes (T2DM) were selected. Their insulin sensitivity index (ISI) was evaluated with euglycemic-hyperinsulinemic clamp after 2 week insulin intensive treatment and compared with that of 10 healthy volunteers (normal control group, NC group).


RESULTS
Age, BMI, fasting insulin (FIns), fasting C-peptide in the T1DM group were significantly lower than those in the NC group, while waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), TC, TG, LDL-C, HDL-C were not significantly different between the T1DM and NC groups. Age, BMI, WHR, FIns, fasting C-peptide, SBP, TC, TG in the T1DM group were significantly lower than those in the T2DM group. The ISI of the NC, T1DM and T2DM groups were 12. 83 +/- 1.09, 9.95 +/-0.50, 3.80 +/- 0.20, respectively. There was significant difference among the three groups (P < 0.05).


CONCLUSIONS
The ISI in T1DM was significantly lower than that in NC group, but higher than that in T2DM.
Luo
Guo-chun
GC
Department of Endocrinology, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
Liang
Zhen
Z
Hu
Qing-hong
QH
Yan
De-wen
DW
Lü
Ling-bo
LB
Gu
Wen-hui
WH
Chen
Ze-long
ZL
Li
Hai-yan
HY
Liu
Ming-ming
MM
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D049629:Waist-Hip Ratio; D055815:Young Adult
D001786:Blood Glucose; D007328:Insulin