title: Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection.
abstract: Mannose-binding lectin (MBL) is a complement component and an opsonic factor recognizing and binding to herpes simplex virus 2 (HSV-2). In this study, we assessed the effect of MBL2 genotypes on the risk of recurring HSV-2 infection. The MBL2 structural variant genotype (A/O or O/O) was more common among the patients with recurrent HSV-2 infection compared with healthy controls (47% vs 26%, respectively; odds ratio [OR] = 2.6, 95% confidence interval [CI] 1.3-4.9; p = 0.005) or controls positive for HSV-2 antibodies (15%; OR 4.9, 95% CI 1.5-16; p = 0.007). Thus, we conclude that the MBL2 structural variant genotype, possibly through impaired recognition of HSV-2, seems to predispose individuals to the development of recurring HSV-2 infection.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, Finland.
authors.forename: Mikko
authors.initials: M
authors.lastname: Seppänen
authors.forename: Marja-Liisa
authors.initials: ML
authors.lastname: Lokki
authors.forename: Maija
authors.initials: M
authors.lastname: Lappalainen
authors.forename: Eija
authors.initials: E
authors.lastname: Hiltunen-Back
authors.forename: Anja T
authors.initials: AT
authors.lastname: Rovio
authors.forename: Saara
authors.initials: S
authors.lastname: Kares
authors.forename: Mikko
authors.initials: M
authors.lastname: Hurme
authors.forename: Janne
authors.initials: J
authors.lastname: Aittoniemi
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006558:Herpes Genitalis / Q000235:genetics* / Q000821:virology; D018258:Herpesvirus 2, Human / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D015810:Linkage Disequilibrium; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics* / Q000378:metabolism; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012008:Recurrence; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D037601:Mannose-Binding Lectin