title: Antimitotic activity of lobaric acid and a new benzofuran, sakisacaulon A from Stereocaulon sasakii.
abstract: Lobaric acid (1) has been isolated from lichen, Stereocaulon sasakii together with a new benzofuran, sakisacaulon A (2). Lobaric acid (1) inhibited the polymerization of tubulin. Structure-activity relationship of lobaric acid and its derivatives on inhibitory activity of tubulin polymerization was discussed.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan. moritah@hoshi.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Tomoe
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: Koji
authors.initials: K
authors.lastname: Kishibe
authors.forename: Sayaka
authors.initials: S
authors.lastname: Noya
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
mesh_terms: D050256:Antimitotic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008011:Lichens / Q000737:chemistry*; D012459:Salicylates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism; D050257:Tubulin Modulators / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D050256:Antimitotic Agents; D001572:Benzofurans; D053630:Depsides; D007783:Lactones; D012459:Salicylates; D014404:Tubulin; D050257:Tubulin Modulators; C542903:sakisacaulon A; C104417:lobaric acid