title: Feedback regulation of Lac repressor expression in Escherichia coli.
abstract: Negative feedback regulation, mediated through repressor binding site O3, which overlaps the lacI gene, could explain the robustness of the weak expression of Lac repressor. Significant autorepression of Lac repressor has never been ruled out. In the work presented here, the degree of autoregulation of Lac repressor was determined. It is negligible.
authors.affiliation: IMBB-FORTH, Nikolaou Plastira 100, GR-70013 Heraklion, Crete, Greece. oehler@fleming.gr
authors.forename: Stefan
authors.initials: S
authors.lastname: Oehler
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics*; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics / Q000502:physiology; D056968:Lac Repressors; D008957:Models, Genetic; D009875:Operator Regions, Genetic / Q000235:genetics* / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics* / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D056968:Lac Repressors; C539064:LacI protein, E coli; D012097:Repressor Proteins