Detection of a novel HLA-B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence-based typing: curiosity rewarded.
We report here a novel HLA-B allele, B*2740, discovered in Taiwanese volunteer marrow donors. The new sequence has nucleotide variation at position 527 (T-->A) as compared to B*2708. The nucleotide change caused an amino acid substitution from valine (V) to glutamic acid (E) at codon 152. Since B*2740 carries sequence confers to HLA-Bw6 public epitope we believe that this novel B*27 allele might have been generated from a gene conversion involving a Bw4-specific allele (probably B*2704) and a Bw6-specific allele.
Chen
M J
MJ
Laboratory of Immunogenetics and Cord Blood Bank, Buddhist Tzu Chi Marrow Donor Registry and Stem Cells Centre, Buddhist Tzu Chi General Hospital, Buddhist Compassion Relief Tzu Chi Foundation, 707 Section 3 Chung Yang Road, Hualien, Taiwan.
Yang
T C
TC
Chu
C C
CC
Shyr
M H
MH
Lin
C L
CL
Lin
P Y
PY
Yang
K L
KL
D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence; D001853:Bone Marrow / Q000378:metabolism; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005091:Exons / Q000235:genetics; D005785:Gene Conversion / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D018698:Glutamic Acid / Q000235:genetics; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D019520:Living Donors; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013624:Taiwan; D014633:Valine / Q000235:genetics
D015796:HLA-B27 Antigen; D018698:Glutamic Acid; D014633:Valine