title: Molecular analysis of HLA-DRB1 allelic associations with systemic lupus erythematous and lupus nephritis in Taiwan.
abstract: To evaluate the association of human leukocyte antigen (HLA)-DRB1 alleles with systemic lupus erythematosus (SLE) and lupus nephritis (LN) in the Taiwanese population, and to investigate the possible association of HLA-DRB1 alleles with disease severity in LN. HLA-DRB1 alleles were studied in 105 SLE patients (82 patients with LN, 23 patients without LN) and 855 healthy controls by polymerase chain reaction and sequence-based typing assays. The frequency of the HLA class II alleles DRB1*0301 (Odds ratio [OR] = 2.01, 95% confidence interval [CI] = 1.31-3.10, Pc = 0.02) and DRB1*1501 (OR = 2.06, 95% CI = 1.36-3.13, Pc = 0.01) were both increased in SLE patients, compared to healthy controls. The frequency of DRB1*1202 was significantly lower in LN patients than in SLE patients without nephritis (OR = 0.23, 95% CI = 0.09-0.57, Pc = 0.01). No specific allele was significantly associated with an increased or decreased risk for severity of LN in this sample. In Taiwanese people, the DRB1*0301 and DRB1*1501 alleles are significant risk factors for SLE, while the DRB1*1202 allele is protective for LN.
authors.affiliation: Departments of Nephrology, Mackay Memorial Hospital, Taipei; Departments of Mackay Medicine, Nursing and Management College, Taipei, Taiwan.
authors.forename: C F
authors.initials: CF
authors.lastname: Pan
authors.forename: C J
authors.initials: CJ
authors.lastname: Wu
authors.forename: H H
authors.initials: HH
authors.lastname: Chen
authors.forename: C W
authors.initials: CW
authors.lastname: Dang
authors.forename: F M
authors.initials: FM
authors.lastname: Chang
authors.forename: H F
authors.initials: HF
authors.lastname: Liu
authors.forename: C C
authors.initials: CC
authors.lastname: Chu
authors.forename: M
authors.initials: M
authors.lastname: Lin
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000483:Alleles; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D008181:Lupus Nephritis / Q000235:genetics* / Q000276:immunology; D008297:Male; D013624:Taiwan
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553502:HLA-DRB1*03:01 antigen; C553514:HLA-DRB1*12:02 antigen