Monkey malaria in humans: a diagnostic dilemma with conflicting laboratory data.
Plasmodium knowlesi has recently been recognized as the fifth Plasmodium species causing malaria in humans. Diagnosis is difficult morphologically, and currently, available rapid tests have not been comprehensively evaluated with this pathogen. We report a case of P. knowlesi malaria that was confirmed after the initial clue of discordant microscopy and immunochromatographic results, highlighting the importance of molecular diagnostics in cases with the relevant clinical and epidemiologic history.
Ong
Catherine W M
CW
National University Health System, Singapore; Defence Medical and Environmental Research Institute, Singapore. catongwm@yahoo.com
Lee
Shir Ying
SY
Koh
Wee Hong
WH
Ooi
Eng-Eong
EE
Tambyah
Paul A
PA
D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use; D016054:DNA, Protozoan / Q000097:blood / Q000737:chemistry; D006801:Humans; D008288:Malaria / Q000175:diagnosis* / Q000188:drug therapy / Q000469:parasitology*; D008297:Male; D016790:Plasmodium knowlesi / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D011319:Primaquine / Q000627:therapeutic use; D012335:RNA, Ribosomal / Q000235:genetics
D000962:Antimalarials; D016054:DNA, Protozoan; D012335:RNA, Ribosomal; D002738:Chloroquine; D011319:Primaquine