title: Strong correlation between VEGF and MCL-1 mRNA expression levels in B-cell chronic lymphocytic leukemia.
abstract: Expression of the anti-apoptotic myeloid cell leukemia-1 (MCL-1) gene is a novel prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL). Vascular and endothelial growth factor (VEGF) and interleukin-6 (IL-6) are able to upregulate MCL-1 via autocrine signaling loops. In 88 B-CLL patients, we found a strong correlation of MCL-1 gene expression with VEGF (P<10(-7)) but not with IL-6 mRNA levels. VEGF but not IL-6 expression influenced patient prognosis. VEGF may be a positive autocrine in vivo regulator of MCL-1 in B-CLL. Inhibition of VEGF and its signaling may prove to be useful in the treatment of B-CLL patients.
authors.affiliation: Univ Clermont 1, Fac Médecine, Histologie Embryologie Cytogénétique, Clermont-Ferrand F-63001, France.
authors.forename: Lauren
authors.initials: L
authors.lastname: Véronèse
authors.forename: Olivier
authors.initials: O
authors.lastname: Tournilhac
authors.forename: Pierre
authors.initials: P
authors.lastname: Verrelle
authors.forename: Frédéric
authors.initials: F
authors.lastname: Davi
authors.forename: Guillaume
authors.initials: G
authors.lastname: Dighiero
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Chautard
authors.forename: Richard
authors.initials: R
authors.lastname: Veyrat-Masson
authors.forename: Fabrice
authors.initials: F
authors.lastname: Kwiatkowski
authors.forename: Carole
authors.initials: C
authors.lastname: Goumy
authors.forename: Laetitia
authors.initials: L
authors.lastname: Gouas
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Bay
authors.forename: Philippe
authors.initials: P
authors.lastname: Vago
authors.forename: Andrei
authors.initials: A
authors.lastname: Tchirkov
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D015850:Interleukin-6 / Q000502:physiology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics* / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D015850:Interleukin-6; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A