title: Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE(2), and TNF-alpha production.
abstract: Three new phenolic glycosides, salviifosides A-C (13), and three known compounds salicin (4), kaempferol (5), and kaempferol 3-O-beta-d-glucopyranoside (6) were isolated from the leaves of Alangium salviifolium (L.f.) Wangerin (Alangiaceae). The structures of the new metabolites were determined on the basic of spectroscopic analyses including two dimensional NMR. The anti-inflammatory activities of new compounds (1-3) were investigated on lipopolysaccharide (LPS)-induced murine macrophage cells line, RAW 264.7. Salviifoside B (2) potentially inhibits the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), and tumor necrosis factor-alpha (TNF-alpha).
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Republic of Korea.
authors.forename: Manh Hung
authors.initials: MH
authors.lastname: Tran
authors.forename: Hai Dang
authors.initials: HD
authors.lastname: Nguyen
authors.forename: Jin Cheol
authors.initials: JC
authors.lastname: Kim
authors.forename: Jae Sue
authors.initials: JS
authors.lastname: Choi
authors.forename: Hyeong Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Min
mesh_terms: D032604:Alangiaceae / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015232:Dinoprostone / Q000378:metabolism*; D006027:Glycosides / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000378:metabolism*; D051379:Mice; D008956:Models, Chemical; D009569:Nitric Oxide / Q000378:metabolism*; D019800:Phenol / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000378:metabolism*; D010946:Plants, Medicinal / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D006027:Glycosides; D008070:Lipopolysaccharides; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D019800:Phenol; D015232:Dinoprostone