title: Protective effect of daily sesame oil supplement on gentamicin-induced renal injury in rats.
abstract: Gentamicin, an aminoglycoside antibiotic, is widely used in the treatment of Gram-negative infections; however, dose-limiting nephrotoxicity restricts its optimal use. We investigated the effect of a daily sesame oil supplement on oxidative-stress-associated renal injury induced by a single daily dose of gentamicin in rats. Renal injury was induced by a single subcutaneous daily dose of gentamicin (100 mg kg(-1) d(-1) for 7 days), and then the effects of oral sesame oil (0.25, 0.5, and 1 mL kg(-1) d(-1) for 7 days) on renal injury, oxidative stress, hydroxyl radical, superoxide anion, and NO were assessed after treatment. Sesame oil inhibited gentamicin-induced renal injury, lipid peroxidation, hydroxyl radical, and superoxide anion, as well as NO production. In addition, sesame oil inhibited xanthine oxidase activity and inducible NOS expression in gentamicin-challenged rats. We hypothesize that a daily sesame oil supplement attenuates oxidative-stress-associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats.
authors.affiliation: Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
authors.forename: Dur-Zong
authors.initials: DZ
authors.lastname: Hsu
authors.forename: Chuan-Teng
authors.initials: CT
authors.lastname: Liu
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Li
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Chu
authors.forename: Ming-Yie
authors.initials: MY
authors.lastname: Liu
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D005839:Gentamicins / Q000633:toxicity*; D017665:Hydroxyl Radical / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012715:Sesame Oil / Q000008:administration & dosage / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism
chemical_list: D005839:Gentamicins; D013481:Superoxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D012715:Sesame Oil