title: Identification of MNDA as a new marker for nodal marginal zone lymphoma.
abstract: Clinical and biological studies on nodal marginal zone lymphoma (NMZL) are hampered by the lack of specific diagnostic markers and the low reproducibility of this diagnosis. A comparative expression-profiling study has shown a set of markers to be differentially expressed in NMZL compared with follicular lymphoma (FL), including myeloid cell nuclear differentiation antigen (MNDA), a nuclear protein expressed by myeloid cells and a subset of B-cells. The aim of this study was to characterize the expression of MNDA in normal and reactive human tissue, and in a large series of non-Hodgkin's B-cell lymphomas, with particular emphasis on NMZL and FL. Our results showed that MNDA is expressed in normal tissue by a subset of the marginal zone B cells. They also showed MNDA expression in subgroups of chronic lymphocytic leukemia, mantle-cell lymphoma, and diffuse large B-cell lymphoma, but MNDA was especially expressed by lymphomas derived from the marginal zone, such as mucosa-associated lymphoid-tissue lymphoma, splenic marginal-zone lymphoma and NMZL. MNDA expression was rarely observed in FL, a characteristic that is of potential value in distinguishing between NMZL and FL. MNDA expression is thus a useful tool for the recognition of NMZL.
authors.affiliation: Molecular Pathology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Kanellis
authors.forename: G
authors.initials: G
authors.lastname: Roncador
authors.forename: A
authors.initials: A
authors.lastname: Arribas
authors.forename: M
authors.initials: M
authors.lastname: Mollejo
authors.forename: S
authors.initials: S
authors.lastname: Montes-Moreno
authors.forename: L
authors.initials: L
authors.lastname: Maestre
authors.forename: Y
authors.initials: Y
authors.lastname: Campos-Martin
authors.forename: J L
authors.initials: JL
authors.lastname: Ríos Gonzalez
authors.forename: J L
authors.initials: JL
authors.lastname: Martinez-Torrecuadrada
authors.forename: L
authors.initials: L
authors.lastname: Sanchez-Verde
authors.forename: R
authors.initials: R
authors.lastname: Pajares
authors.forename: J C
authors.initials: JC
authors.lastname: Cigudosa
authors.forename: M C
authors.initials: MC
authors.lastname: Martin
authors.forename: M A
authors.initials: MA
authors.lastname: Piris
mesh_terms: D000818:Animals; D015214:Antigens, Differentiation, Myelomonocytic / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D015153:Blotting, Western; D005455:Fluorescent Antibody Technique; D020869:Gene Expression Profiling; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000276:immunology; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008224:Lymphoma, Follicular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D046888:Tissue Array Analysis; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D007074:Immunoglobulin G; C075373:MNDA protein, human; D014157:Transcription Factors