Rhabdomyolysis following clarithromycin monotherapy.
Macrolide antibiotics inhibit the metabolism of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) that may result in myopathy and rhabdomyolysis. We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications. Inhibition of cytochrome P450 could be one of the potential causative mechanisms of myopathy in our case. Clinicians should be aware of this potential adverse effect of a widely used drug.
Brener
Zachary Z
ZZ
Department of Medicine, Beth Israel Medical Center, New York, New York 10003, USA. brenerz@yahoo.com
Bilik
Ilya
I
Khorets
Boris
B
Winchester
James F
JF
Bergman
Michael
M
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017291:Clarithromycin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000150:complications; D012852:Sinusitis / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D017291:Clarithromycin