title: Coccidioides immitis meningitis in a patient with hyperimmunoglobulin E syndrome due to a novel mutation in signal transducer and activator of transcription.
abstract: Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency characterized by recurrent skin and lung infections. We report the first case of Coccidioides immitis meningitis in a patient with HIES. Coccidioides should be included in the differential diagnosis for central nervous system infections in HIES patients.
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA. annie.eisinger@hsc.utah.edu
authors.forename: Annie E
authors.initials: AE
authors.lastname: Powers
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Bender
authors.forename: Attila
authors.initials: A
authors.lastname: Kumánovics
authors.forename: Krow
authors.initials: K
authors.lastname: Ampofo
authors.forename: Nancy
authors.initials: N
authors.lastname: Augustine
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Pavia
authors.forename: Harry R
authors.initials: HR
authors.lastname: Hill
mesh_terms: D000293:Adolescent; D019943:Amino Acid Substitution / Q000235:genetics; D000666:Amphotericin B / Q000627:therapeutic use; D000908:Antibodies, Fungal / Q000134:cerebrospinal fluid; D000935:Antifungal Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003045:Coccidioides / Q000302:isolation & purification*; D003047:Coccidioidomycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007589:Job Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016921:Meningitis, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D020125:Mutation, Missense; D050796:STAT3 Transcription Factor / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D000908:Antibodies, Fungal; D000935:Antifungal Agents; D007074:Immunoglobulin G; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D000666:Amphotericin B