title: Rhabdomyolysis following clarithromycin monotherapy.
abstract: Macrolide antibiotics inhibit the metabolism of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) that may result in myopathy and rhabdomyolysis. We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications. Inhibition of cytochrome P450 could be one of the potential causative mechanisms of myopathy in our case. Clinicians should be aware of this potential adverse effect of a widely used drug.
authors.affiliation: Department of Medicine, Beth Israel Medical Center, New York, New York 10003, USA. brenerz@yahoo.com
authors.forename: Zachary Z
authors.initials: ZZ
authors.lastname: Brener
authors.forename: Ilya
authors.initials: I
authors.lastname: Bilik
authors.forename: Boris
authors.initials: B
authors.lastname: Khorets
authors.forename: James F
authors.initials: JF
authors.lastname: Winchester
authors.forename: Michael
authors.initials: M
authors.lastname: Bergman
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017291:Clarithromycin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000150:complications; D012852:Sinusitis / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin