title: Solar simulated ultraviolet radiation damages murine neonatal skin and alters Langerhans cell development, but does not induce inflammation.
abstract: Development of melanoma has been linked to excessive childhood exposure to sunlight. As neonates have a relatively underdeveloped immune system, it is likely that the immune system reacts differently to the exposure, leading to alterations in this development. This study was designed to assess changes in development of the skin immune system following neonatal irradiation. Ultraviolet radiation exposure led to relative depletion of Langerhans cells, however this was not due to migration or cell death, but rather restriction of Langerhans cells populating the epidermis. During this time, there was evidence of cellular damage, however there was no induction of an inflammatory response. It therefore appears that neonatal exposure to ultraviolet radiation leads to a skew towards a tolerogenic immune response, which may lead to a reduced ability to respond to ultraviolet radiation-induced tumours.
authors.affiliation: Menzies Research Institute, University of Tasmania, Hobart, Australia.
authors.forename: Heather M
authors.initials: HM
authors.lastname: McGee
authors.forename: Thanuja
authors.initials: T
authors.lastname: Dharmadasa
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Woods
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000528:radiation effects; D002465:Cell Movement / Q000528:radiation effects; D004249:DNA Damage; D005260:Female; D007249:Inflammation; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology* / Q000528:radiation effects*; D008198:Lymph Nodes / Q000276:immunology / Q000528:radiation effects; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000276:immunology* / Q000473:pathology*; D012867:Skin / Q000276:immunology* / Q000473:pathology / Q000528:radiation effects*; D013471:Sunburn / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects*