title: Hepatic perfusion changes in an experimental model of acute pancreatitis: evaluation by perfusion CT.
abstract: OBJECTIVE
  It is known that acute pancreatitis may cause secondary changes in several organs. Liver is one of these involved organs. In different experimental studies hepatic damages were shown histopathologically in acute pancreatitis but there are a few studies about perfusion disorders that accompany these histopathologic changes. Perfusion CT (pCT) provides the ability to detect regional and global alterations in organ blood flow. The purpose of the study was to describe hepatic perfusion changes in experimental acute pancreatitis model with pCT.
  
  
  METHODS
  Forty Sprague-Dawley rats of both genders with average weights of 250 g were used. Rats were randomized into two groups. Twenty rats were in control group and 20 in acute pancreatitis group. pCT was performed. Perfusion maps were formed by processing the obtained images with perfusion CT software. Blood flow (BF) and blood volume (BV) values were obtained from these maps. All pancreatic and liver tissues were taken off with laparotomy and histopathologic investigation was performed. Student's t test was used for statistical analyses.
  
  
  RESULTS
  In pCT we found statistically significant increase in blood volume in both lobes of liver and in blood flow in right lobe of the liver (p<0.01). Although blood flow in left lobe of the liver increased, it did not reach statistical significance.
  
  
  CONCLUSIONS
  The quantitative analysis of liver parenchyma with pCT showed that acute pancreatitis causes a significant perfusion changes in the hepatic tissue. Systemic mediators seem to be effective as well as local inflammatory changes in perfusion changes.
authors.affiliation: Department of Surgery, Celal Bayar University, School of Medicine, Manisa, Turkey.
authors.forename: Semra
authors.initials: S
authors.lastname: Tutcu
authors.forename: Selim
authors.initials: S
authors.lastname: Serter
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Kaya
authors.forename: Eray
authors.initials: E
authors.lastname: Kara
authors.forename: Nalan
authors.initials: N
authors.lastname: Neşe
authors.forename: Gökhan
authors.initials: G
authors.lastname: Pekindil
authors.forename: Teoman
authors.initials: T
authors.lastname: Coşkun
mesh_terms: D000208:Acute Disease; D000818:Animals; D001810:Blood Volume; D008099:Liver / Q000098:blood supply* / Q000000981:diagnostic imaging; D010195:Pancreatitis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D055420:Perfusion Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D014057:Tomography, X-Ray Computed