Local C-reactive protein expression in obliterative lesions and the bronchial wall in posttransplant obliterative bronchiolitis.
The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2-28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells (P < .0001) and fibroblasts (P = .02) resulted in occlusion of the bronchial lumens (P < .01). Influx of CD4+ (P < .001) and CD8+ (P < .0001) cells demonstrated allograft immune response. CRP positivity simultaneously increased in the bronchial walls (P < .01), in macrophages, myofibroblasts, and endothelial cells. Local CRP was predictive of features characteristic of OB (R = 0.456-0.879, P < .05-P < .0001). Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs (P < .05). During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.
Päiväniemi
Outi E
OE
Department of Cardiothoracic Surgery, Helsinki University Hospital, P.O. Box 340, 00029 Helsinki, Finland. outi.paivaniemi@uta.fi
Maasilta
Paula K
PK
Vainikka
Tiina L S
TL
Alho
Hanni S
HS
Karhunen
Pekka J
PJ
Salminen
Ulla-Stina
US
D000818:Animals; D001980:Bronchi / Q000276:immunology* / Q000473:pathology / Q000637:transplantation*; D001989:Bronchiolitis Obliterans / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000276:immunology; D007150:Immunohistochemistry; D013552:Swine; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous / Q000009:adverse effects
D002097:C-Reactive Protein