Subjective improvement in proprioception in 2 patients with atypical Friedreich ataxia treated with varenicline (Chantix).
Two patients with atypical Friedreich ataxia (heterozygotes for a GAA expansion and a G130V point mutation) experienced modest proprioceptive improvements in their extremities within a month of taking varenicline (Chantix), a drug approved for smoking cessation.
Zesiewicz
Theresa A
TA
Department of Neurology, University of South Florida Ataxia Research Center, Tampa, FL 33612, USA. tzesiewi@health.usf.edu
Sullivan
Kelly L
KL
Gooch
Clifton L
CL
Lynch
David R
DR
D001552:Benzazepines / Q000627:therapeutic use*; D005621:Friedreich Ataxia / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D011434:Proprioception / Q000187:drug effects*; D011810:Quinoxalines / Q000627:therapeutic use*; D035781:Siblings; D000068580:Varenicline
D001552:Benzazepines; D018722:Nicotinic Agonists; D011810:Quinoxalines; D000068580:Varenicline