title: Management of intraductal papillomas of the breast: an analysis of 129 cases and their outcome.
abstract: BACKGROUND
  The management of intraductal papillomas of the breast has been controversial; some advocate surgical excision of all lesions despite benign pathologic features, whereas others excise only those specimens with atypia.
  
  
  METHODS
  We conducted a retrospective review of 129 core-biopsy-proven papillomas of the breast with atypia (n = 43) and without atypia (n = 86) and determined the rate of missed carcinoma in surgically excised specimen in each group.
  
  
  RESULTS
  Carcinoma was found in 22.5% of the surgically excised specimens in the atypia group (9/40) and in 3% of the surgically excised specimens in the no atypia group (1/29).
  
  
  CONCLUSIONS
  Our findings confirm the practice that papillomas with atypical features should be excised, and suggest that in patients with adequate follow-up, benign papillomas may be managed conservatively.
authors.affiliation: Department of Surgery, Brigham and Women's Hospital and the Dana Farber Cancer Institute, Boston, MA, USA.
authors.forename: Nasim
authors.initials: N
authors.lastname: Ahmadiyeh
authors.forename: Mariana A
authors.initials: MA
authors.lastname: Stoleru
authors.forename: Sughra
authors.initials: S
authors.lastname: Raza
authors.forename: Susan C
authors.initials: SC
authors.lastname: Lester
authors.forename: Mehra
authors.initials: M
authors.lastname: Golshan
mesh_terms: D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D018300:Papilloma, Intraductal / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome