The influence of eccentric scanning of optical coherence tomography on retinal nerve fiber layer analysis in normal subjects.
OBJECTIVE
To investigate the influence of eccentric scanning on retinal nerve fiber layer (RNFL) analysis using Stratus optical coherence tomography (OCT) in normal Koreans when the eccentricity of scanning occurs in 4 different directions.


METHODS
Thirty-one eyes of 31 persons underwent 1 concentric disk-centered and 4 superiorly, inferiorly, nasally and temporally eccentric RNFL OCT scans.


RESULTS
The average RNFL thickness measured by temporally eccentric scanning (115.1 microm) was significantly greater when compared with that found by concentric scanning (107.1 microm; p < 0.0001). The proportions of eyes outside normal limits on the RNFL analysis map using the criterion of >or=1 clock hour abnormal at the <1% level in superiorly (12/31, 38.7%), nasally (16/32, 51.6%) and temporally (12/31, 38.7%) eccentric scans were significantly different in comparison with the concentric (4/31, 12.9%) scan (p < 0.05).


CONCLUSIONS
An off-centered OCT scan affected RNFL thickness measurement and its interpretation.
Yoo
Chungkwon
C
Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Suh
Il Hoon
IH
Kim
Yong Yeon
YY
D000328:Adult; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D009412:Nerve Fibers; D009898:Optic Disk / Q000033:anatomy & histology; D009900:Optic Nerve / Q000033:anatomy & histology*; D012016:Reference Values; D012165:Retinal Ganglion Cells / Q000166:cytology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014065:Tonometry, Ocular; D014794:Visual Fields / Q000502:physiology