title: [C-reactive protein and risk of ischaemic vascular and cerebrovascular disease--secondary publication].
abstract: Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease.
authors.affiliation: Herlev Hospital, Klinisk Biokemisk Afdeling.
authors.forename: Jeppe
authors.initials: J
authors.lastname: Zacho
authors.forename: Anne
authors.initials: A
authors.lastname: Tybjaerg-Hansen
authors.forename: Jan Skov
authors.initials: JS
authors.lastname: Jensen
authors.forename: Peer
authors.initials: P
authors.lastname: Grande
authors.forename: Henrik
authors.initials: H
authors.lastname: Sillesen
authors.forename: Børge G
authors.initials: BG
authors.lastname: Nordestgaard
mesh_terms: D050197:Atherosclerosis / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis* / Q000235:genetics; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000235:genetics; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D017202:Myocardial Ischemia / Q000097:blood* / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein