Proliferation of cardiomyocytes: a question unresolved.
In the past, human heart has been considered a post-mitotic organ formed by cells, like adult cardiomyocytes, terminally differentiated and incapable of proliferation. This paradigm has been shaken by recent works indicating that postnatal adult cardiomyocytes are able to re-enter in the cell cycle and proliferate. In this view, the understanding of main candidates regulating cardiomyocyte cell cycle is of vital importance for future clinical approach.
De Falco
Maria
M
Department of Biological Sciences, Section of Evolutionary and Comparative Biology, University Federico II of Naples, Naples, Italy.
Cobellis
Gilda
G
De Luca
Antonio
A
D000328:Adult; D002453:Cell Cycle / Q000502:physiology*; D049109:Cell Proliferation; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006321:Heart / Q000254:growth & development*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D020928:Mitogen-Activated Protein Kinases