Gastroprotective constituents of Salvia officinalis L.
The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H(+),K(+)-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE.
Mayer
Bárbara
B
Departamento de Farmacologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Baggio
Cristiane Hatsuko
CH
Freitas
Cristina Setim
CS
dos Santos
Ana Cristina
AC
Twardowschy
André
A
Horst
Heros
H
Pizzolatti
Moacir Geraldo
MG
Micke
Gustavo Amadeu
GA
Heller
Melina
M
dos Santos
Elide Pereira
EP
Otuki
Michel Fleith
MF
Marques
Maria Consuelo Andrade
MC
D045784:Abietanes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000431:Ethanol; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D054328:Proton Pump Inhibitors; D051381:Rats; D017208:Rats, Wistar; D027543:Salvia officinalis / Q000737:chemistry*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D045784:Abietanes; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D054328:Proton Pump Inhibitors; D000431:Ethanol; C068623:carnosol; D019342:Acetic Acid