Gendoo: functional profiling of gene and disease features using MeSH vocabulary.
Genome-wide data enables us to clarify the underlying molecular mechanisms of complex phenotypes. The Online Mendelian Inheritance in Man (OMIM) is a widely employed knowledge base of human genes and genetic disorders for biological researchers. However, OMIM has not been fully exploited for omics analysis because its bibliographic data structure is not suitable for computer automation. Here, we characterized diseases and genes by generating feature profiles of associated drugs, biological phenomena and anatomy with the MeSH (Medical Subject Headings) vocabulary. We obtained 1 760 054 pairs of OMIM entries and MeSH terms by utilizing the full set of MEDLINE articles. We developed a web-based application called Gendoo (gene, disease features ontology-based overview system) to visualize these profiles. By comparing feature profiles of types 1 and 2 diabetes, we clearly illustrated their differences: type 1 diabetes is an autoimmune disease (P-value = 4.55 x 10(-5)) and type 2 diabetes is related to obesity (P-value = 1.18 x 10(-15)). Gendoo and the developed feature profiles should be useful for omics analysis from molecular and clinical viewpoints. Gendoo is available at http://gendoo.dbcls.jp/.
Nakazato
Takeru
T
Database Center for Life Science, Research Organization of Information and Systems, Faculty of Engineering Building 12, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. nakazato@dbcls.rois.ac.jp
Bono
Hidemasa
H
Matsuda
Hideo
H
Takagi
Toshihisa
T
D030541:Databases, Genetic; D003920:Diabetes Mellitus / Q000145:classification; D004194:Disease / Q000235:genetics*; D005796:Genes; D020407:Internet; D046650:Medical Subject Headings; D012984:Software