[Paraneoplastic chorea and behavioral disorders in a patient with anti-CV2/CRMP5 antibodies and two different tumors].
BACKGROUND
Paraneoplastic movement disorders are rare. Reported cases frequently describe association with anti-CV2/CRMP5 antibodies.


METHODS
We report a case of an 80-year-old man who developed sensorial neuronopathy, following by movement disorders mimicking chorea and obsessive-compulsive and behavioral disorders. These manifestations were first considered to be associated with a prostatic adenocarcinoma but PET and surgical biopsy revealed a mediastinal small cell lung carcinoma classically associated with anti-CV2/CRMP5 antibodies.


CONCLUSIONS
This case demonstrates that in a context of paraneoplastic neurological syndrome, search for a classically associated cancer is necessary in order to institute adapted treatment early, even if another tumor is obvious.
Ritzenthaler
T
T
Service de neurologie B, hôpital neurologique Pierre-Wertheimer, 59, boulevard Pinel, 69677 Bron, France.
Verret
J-M
JM
Honnorat
J
J
D000369:Aged, 80 and over; D001323:Autoantibodies / Q000276:immunology*; D002819:Chorea / Q000150:complications / Q000000981:diagnostic imaging; D050171:Dyslipidemias / Q000150:complications; D004568:Electrodiagnosis; D019788:Fluorodeoxyglucose F18; D006801:Humans; D006867:Hydrolases; D008279:Magnetic Resonance Imaging; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications / Q000473:pathology; D001523:Mental Disorders / Q000150:complications* / Q000209:etiology; D008869:Microtubule-Associated Proteins; D009203:Myocardial Infarction / Q000150:complications; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009771:Obsessive-Compulsive Disorder / Q000209:etiology / Q000523:psychology; D020364:Paraneoplastic Polyneuropathy / Q000150:complications* / Q000000981:diagnostic imaging / Q000209:etiology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D055752:Small Cell Lung Carcinoma / Q000150:complications / Q000473:pathology; D014057:Tomography, X-Ray Computed
D001323:Autoantibodies; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C415087:DPYSL5 protein, human; D006867:Hydrolases