Association analysis between schizophrenia and the AP-3 complex genes.
A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (chi(2)=6.33, P=0.012, odds ratio=0.80) was no longer positive after correction for multiple testing (corrected P=0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.
Hashimoto
Ryota
R
The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan. hashimor@psy.med.osaka-u.ac.jp
Ohi
Kazutaka
K
Okada
Takeya
T
Yasuda
Yuka
Y
Yamamori
Hidenaga
H
Hori
Hiroaki
H
Hikita
Takao
T
Taya
Shinichiro
S
Saitoh
Osamu
O
Kosuga
Asako
A
Tatsumi
Masahiko
M
Kamijima
Kunitoshi
K
Kaibuchi
Kozo
K
Takeda
Masatoshi
M
Kunugi
Hiroshi
H
D033963:Adaptor Protein Complex 3 / Q000235:genetics*; D033983:Adaptor Protein Complex mu Subunits / Q000235:genetics*; D000328:Adult; D002352:Carrier Proteins / Q000235:genetics; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
D033963:Adaptor Protein Complex 3; D033983:Adaptor Protein Complex mu Subunits; D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins