The role of surface energy of technical polymers in serum protein adsorption and MG-63 cells adhesion.
Polymeric materials are widely used as supports for cell culturing in medical implants and as scaffolds for tissue regeneration. However, novel applications in the biosensor field require materials to be compatible with cell growth and at the same time be suitable for technological processing. Technological polymers are key materials in the fabrication of disposable parts and other sensing elements. As such, it is essential to characterize the surface properties of technological polymers, especially after processing and sterilization. It is also important to understand how technological polymers affect cell behavior when in contact with polymer materials. Therefore, the aim of this research was to study how surface energy and surface roughness affect the biocompatibility of three polymeric materials widely used in research and industry: poly(methyl methacrylate), polystyrene, and poly(dimethylsiloxane). Glass was used as the control material.


BACKGROUND
Polymeric materials are widely used as supports for cell culturing in medical implants and as scaffolds for tissue regeneration. The aim of this research is to study how surface energy and surface roughness affect the biocompatibility of three polymeric materials widely used in research and industry: poly(methylmethacrylate) (PMMA), polystyrene (PS), and poly(dimethylsiloxane) (PDMS).
Comelles
Jordi
J
Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain. jcomelles@ibec.pcb.ub.es
Estévez
Maruxa
M
Martínez
Elena
E
Samitier
Josep
J
D000327:Adsorption / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004129:Dimethylpolysiloxanes / Q000494:pharmacology*; D006801:Humans; D018625:Microscopy, Atomic Force; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects*; D019904:Polymethyl Methacrylate / Q000494:pharmacology*; D011137:Polystyrenes / Q000494:pharmacology*; D013499:Surface Properties / Q000187:drug effects; D013816:Thermodynamics
D001798:Blood Proteins; D004129:Dimethylpolysiloxanes; D011137:Polystyrenes; D019904:Polymethyl Methacrylate