The NLRP3 inflammasome: a sensor of immune danger signals.
The innate immune system senses danger signals via evolutionary conserved receptors. The nucleotide-binding domain leucine-rich repeat containing receptor (NLR) family is a group of intracellular receptors that drive a wide variety of inflammatory responses. A number of the NLR family members can form inflammasomes, which are multiprotein complexes that can activate caspase-1 and ultimately lead to the processing and secretion of interleukin (IL)-1beta, IL-18 and IL-33. One of the best-studied members of the NLR family is NLRP3 for which a number of divergent activators have recently been described. These and other studies examining the NLRP3 inflammasome will be discussed in this review.
Cassel
Suzanne L
SL
Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA. suzanne-cassel@uiowa.edu
Joly
Sophie
S
Sutterwala
Fayyaz S
FS
D000818:Animals; D001692:Biological Transport; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D014612:Vaccines / Q000276:immunology
D043562:Receptors, G-Protein-Coupled; D014612:Vaccines