title: Left ventricular infarct size assessed with 0.1 mmol/kg of gadobenate dimeglumine correlates with that assessed with 0.2 mmol/kg of gadopentetate dimeglumine.
abstract: OBJECTIVE
  To determine myocardial infarct (MI) size during cardiovascular magnetic resonance at 1.5 Tesla using 0.1 mmol/kg body weight of gadobenate dimeglumine (Gd-BOPTA) and 0.2 mmol/kg body weight of gadopentetate dimeglumine (Gd-DTPA).
  
  
  METHODS
  Twenty participants (16 men, 4 women), aged 58 +/- 12 years, with a prior chronic MI were imaged in a crossover design. Participants received 0.2 mmol/kg body weight of Gd-DTPA and 0.1 mmol/kg body weight of Gd-BOPTA on 2 occasions separated by 3 to 7 days.
  
  
  RESULTS
  The correlations were high between Gd-DTPA and Gd-BOPTA measures of infarct volume (r = 0.93) and the percentage of infarct relative to left ventricular myocardial volume (r = 0.85). The size and location of the infarcts were similar (P = 0.9) for the 2 contrast agents. Interobserver correlation of infarct volume (r = 0.91) was high.
  
  
  CONCLUSIONS
  In chronic MI, late gadolinium enhancement identified with a single 0.1 mmol/kg body weight dose of Gd-BOPTA is associated in volume and location to a double (0.2 mmol/kg body weight) dose of Gd-DTPA. Lower doses of higher relaxivity contrast agents should be considered for determining left ventricular myocardial infarct size.
authors.affiliation: Department of Internal Medicine (Cardiology Section), Wake Forest University School of Medicine, Winston-Salem, NC 27157-1045, USA.
authors.forename: Monravee
authors.initials: M
authors.lastname: Tumkosit
authors.forename: Chirapa
authors.initials: C
authors.lastname: Puntawangkoon
authors.forename: Tim M
authors.initials: TM
authors.lastname: Morgan
authors.forename: Hollins P
authors.initials: HP
authors.lastname: Clark
authors.forename: Craig A
authors.initials: CA
authors.lastname: Hamilton
authors.forename: William O
authors.initials: WO
authors.lastname: Ntim
authors.forename: Paige B
authors.initials: PB
authors.lastname: Clark
authors.forename: W Gregory
authors.initials: WG
authors.lastname: Hundley
mesh_terms: D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology*; D009942:Organometallic Compounds / Q000008:administration & dosage*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000473:pathology*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA