title: The first total synthesis of (+/-)-apparicine.
abstract: The first total synthesis of the indole alkaloid apparicine has been developed through a sequence that includes an indole-templated ring-closing metathesis and a vinyl halide Heck cyclization.
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Pharmacy and Institut de Biomedicina (IBUB), University of Barcelona, Barcelona 08028, Spain. bennasar@ub.edu
authors.forename: M-Lluïsa
authors.initials: ML
authors.lastname: Bennasar
authors.forename: Ester
authors.initials: E
authors.lastname: Zulaica
authors.forename: Daniel
authors.initials: D
authors.lastname: Solé
authors.forename: Sandra
authors.initials: S
authors.lastname: Alonso
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007211:Indoles / Q000737:chemistry; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D000470:Alkaloids; D007211:Indoles; D014753:Vinyl Compounds; C008811:pericalline; C030374:indole