Pain: Do ACE inhibitors exacerbate complex regional pain syndrome?
Complex regional pain syndrome is a chronic condition arising mainly after tissue injury and involves both inflammatory and neurogenic factors. Use of angiotensin-converting-enzyme inhibitors has been associated with an increased risk of developing the chronic pain condition, which suggests possible roles for substance P and bradykinin in the underlying pathogenic process.
Borsook
David
D
P.A.I.N. group, Department of Psychiatry, McLean Hospital, Belmont, MA, USA.
Sava
Simona
S
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D020918:Complex Regional Pain Syndromes / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced; D010146:Pain / Q000139:chemically induced*
D000806:Angiotensin-Converting Enzyme Inhibitors