title: Are there sex-based differences in serum troponin I after cardiac surgery?
abstract: OBJECTIVE
  To determine whether there are sex-based differences in serum troponin I (TnI) after cardiac surgery with cardiopulmonary bypass.
  
  
  METHODS
  Prospective, observational, cohort study.
  
  
  METHODS
  Tertiary cardiac surgery intensive care unit (ICU) at a university hospital.
  
  
  METHODS
  None.
  
  
  RESULTS
  Serum TnI was measured in samples obtained at ICU admission and 6, 12, 24, and 48 hours later. A total of 761 consecutive patients were studied (444 men and 317 women). The characteristics and results of the different sex subgroups were as follows:A) Coronary bypass: 165 men and 38 women. Age, Parsonnet score, Acute Physiology and Chronic Health Evaluation III score, prevalence of renal failure, intra-aortic balloon use, and the lengths of cardiopulmonary bypass, mechanical ventilation, and ICU stay were similar in the two groups. Body mass index, red-cell transfusion needs, and use of noradrenaline were significantly higher in women, whereas dobutamine requirements were higher in men. Mortality: 3 men (1.6%) vs. 0 women (p = not significant).The TnI peak was slightly, but significantly, higher in men (6.2 +/- 4.9 vs. 4.5 +/- 2.6 microg/L. p < 0.05).B) Valve surgery: 279 men and 279 women. Some significant differences were found: Women were older than men and had higher Parsonnet score and transfusion needs. The other recorded variables were similar. Mitral prosthesis: 62 men and 125 women (p < 0.05). Mitral valvuloplasty: 24 men, 7 women (p < 0.05). Aortic prosthesis: 162 men, 103 women (p < 0.05). Mitral and aortic prosthesis: 31 men and 44 women (p < 0.05). TnI peaks were similar for both sexes in each valve subgroup. Mortality: 3 men (1%) vs. 11 women (3.4%) (p < 0.05).The TnI peak did not reach any significant differences between sexes (men 7.9 +/- 6.0 vs. 8.5 +/- 6.5 microg/L in women. p = not significant).
  
  
  CONCLUSIONS
  No clinically relevant sex-based differences were found in the TnI peaks after cardiac surgery.
authors.affiliation: Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain. 8936ard@comb.es
authors.forename: Antoni
authors.initials: A
authors.lastname: Ricart
authors.forename: Elisabet
authors.initials: E
authors.lastname: Farrero
authors.forename: Josep L
authors.initials: JL
authors.lastname: Ventura
authors.forename: Casimiro
authors.initials: C
authors.lastname: Javierre
authors.forename: Lluïsa
authors.initials: L
authors.lastname: Carrió
authors.forename: David
authors.initials: D
authors.lastname: Rodríguez
authors.forename: Herminia
authors.initials: H
authors.lastname: Torrado
authors.forename: Daniel
authors.initials: D
authors.lastname: Ortiz
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology / Q000401:mortality; D000368:Aged; D002315:Cardiopulmonary Bypass / Q000401:mortality; D002404:Catheterization; D001026:Coronary Artery Bypass / Q000401:mortality; D003422:Critical Care; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000097:blood* / Q000401:mortality / Q000601:surgery; D006351:Heart Valves / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D012737:Sex Factors; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I