Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea.
The antimalarial susceptibility of ring stage (> 80%) Plasmodium vivax from the Republic of Korea, where long incubation-period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005-2007, susceptibility to seven antimalarial drugs was evaluated with 24 fresh isolates. The geometric mean (95% confidence interval) 50% inhibition concentration (IC(50)) were quinine 60 (54-75) ng/mL, chloroquine 39 (22-282) ng/mL, piperaquine 27 (17-58) ng/mL, mefloquine 39 (35-67) ng/mL, pyrimethamine 138 (89-280) ng/mL, artesunate 0.6 (0.5-0.8) ng/mL, and primaquine 122 (98-232) ng/mL. Positive correlations were found between quinine and mefloquine (r = 0.6, P = 0.004), piperaquine and chloroquine (r = 0.6, P = 0.008), and piperaquine and primaquine IC(50) values (r = 0.5, P = 0.01). Compared with P. vivax in Thailand, P. vivax in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate.
Chotivanich
Kesinee
K
Faculty of Tropical Medicine, and Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Sattabongkot
Jetsumon
J
Choi
Yien Kyong
YK
Park
Jae Sun
JS
Sritabal
Juntima
J
Lim
Chae Seung
CS
Udomsangpetch
Rachanee
R
White
Nicholas J
NJ
Lee
Won Ja
WJ
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004351:Drug Resistance; D006801:Humans; D020128:Inhibitory Concentration 50; D007723:Korea; D021261:Parasitic Sensitivity Tests; D010966:Plasmodium vivax / Q000187:drug effects*
D000962:Antimalarials