title: The collagen receptor DDR2 is expressed during early cardiac development.
abstract: Discoidin Domain Receptor 2 (DDR2) is a receptor tyrosine kinase which has been shown to regulate cell migration upon binding its ligand, collagen. Expression studies determined that DDR2 mRNA and protein are present in the atrioventricular canal during epithelial-mesenchymal transformation (EMT) and the receptor is expressed in both activated endothelial and migrating mesenchymal cells in vivo.
authors.affiliation: Department of Cell, Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, South Carolina, USA.
authors.forename: Edie C
authors.initials: EC
authors.lastname: Goldsmith
authors.forename: Xiadong
authors.initials: X
authors.lastname: Zhang
authors.forename: James
authors.initials: J
authors.lastname: Watson
authors.forename: Josh
authors.initials: J
authors.lastname: Hastings
authors.forename: Jay D
authors.initials: JD
authors.lastname: Potts
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002642:Chick Embryo; D003094:Collagen / Q000378:metabolism*; D000070818:Discoidin Domain Receptors; D054089:Endocardial Cushions / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D004699:Endocardium / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006321:Heart / Q000196:embryology*; D006325:Heart Atria / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D006352:Heart Ventricles / Q000166:cytology / Q000378:metabolism; D008648:Mesoderm / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D038081:Organogenesis / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D038981:Receptors, Collagen / Q000235:genetics / Q000378:metabolism*; D011975:Receptors, Mitogen / Q000235:genetics / Q000378:metabolism*
chemical_list: D038981:Receptors, Collagen; D011975:Receptors, Mitogen; D003094:Collagen; D000070818:Discoidin Domain Receptors; D020794:Receptor Protein-Tyrosine Kinases