title: Best practices in compound management for preserving compound integrity and accurately providing samples for assays.
abstract: Preserving the integrity of the compound collection and providing high-quality materials for drug discovery in an efficient and cost-effective manner are 2 major challenges faced by compound management (CM) at Bristol-Myers Squibb (BMS). The demands on CM include delivering hundreds of thousands of compounds a year to a variety of operations. These operations range from single-compound requests to hit identification support and just-in-time assay plate provision for lead optimization. Support needs for these processes consist of the ability to rapidly provide compounds as solids or solutions in a variety of formats, establishing proper long- and short-term storage conditions and creating appropriate methods for handling concentrated, potent compounds for delivery to sensitive biological assays. A series of experiments evaluating the effects of processing compounds with volatile solvents, storage conditions that can induce freeze/thaw cycles, and the delivery of compounds were performed. This article presents the results of these experiments and how they affect compound integrity and the accuracy of compound management processes.
authors.affiliation: Department of Applied Biotechnologies, Bristol-Myers Squibb, Wallingford, Connecticut 06492, USA. sandra.matson@bms.com
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Matson
authors.forename: Moneesh
authors.initials: M
authors.lastname: Chatterjee
authors.forename: David A
authors.initials: DA
authors.lastname: Stock
authors.forename: John E
authors.initials: JE
authors.lastname: Leet
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Dumas
authors.forename: Christian D
authors.initials: CD
authors.lastname: Ferrante
authors.forename: William E
authors.initials: WE
authors.lastname: Monahan
authors.forename: Lynda S
authors.initials: LS
authors.lastname: Cook
authors.forename: John
authors.initials: J
authors.lastname: Watson
authors.forename: Normand J
authors.initials: NJ
authors.lastname: Cloutier
authors.forename: Meredith A
authors.initials: MA
authors.lastname: Ferrante
authors.forename: John G
authors.initials: JG
authors.lastname: Houston
authors.forename: Martyn N
authors.initials: MN
authors.lastname: Banks
mesh_terms: D001681:Biological Assay / Q000295:instrumentation / Q000379:methods / Q000592:standards; D055808:Drug Discovery / Q000295:instrumentation / Q000379:methods; D004355:Drug Stability; D004364:Pharmaceutical Preparations / Q000737:chemistry; D015203:Reproducibility of Results
chemical_list: D004364:Pharmaceutical Preparations