Protective and therapeutic effects of resveratrol on acetic acid-induced gastric ulcer.
Sprague Dawley rats of both sexes were injected with either saline or RVT (10 mg/kg) either before or after acetic acid ulcer induction and decapitated 3, 5 or 10 days after ulcer. In the saline-treated ulcer groups, macroscopically evident ulcers were observed, while RVT-pretreated or RVT-treated groups had lower macroscopic ulcer scores. Likewise, the microscopic damage scores were lower for the RVT-administered groups. Gastric myeloperoxidase activity, malondialdehyde, collagen and tumour necrosis factor-alpha levels, as well as luminol- and lucigenin-enhanced chemiluminescence levels that were elevated in the saline-administered ulcer groups, were depressed with both RVT-pretreatment and RVT-treatment. Moreover, depleted glutathione levels in the ulcer groups were increased back to control levels by both pre- and post-treatments of RVT. Results demonstrate that resveratrol has both protective and therapeutic effects on oxidative gastric damage by suppressing pro-inflammatory cascades, including the activation of pro-inflammatory cytokines, accumulation of neutrophils and release of oxygen-derived free radicals.
Solmaz
Ali
A
Department of General Surgery, Marmara University School of Medicine, Istanbul, Turkey.
Sener
Göksel
G
Cetinel
Sule
S
Yüksel
Meral
M
Yeğen
Cumhur
C
Yeğen
Berrak C
BC
D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D005260:Female; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D007509:Irritants / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D049449:Luminescence; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D009195:Peroxidase / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D007509:Irritants; D013267:Stilbenes; D008315:Malondialdehyde; D009195:Peroxidase; D005978:Glutathione; D000077185:Resveratrol; D019342:Acetic Acid