The role of the human hippocampus in odor-place associative memory.
Hippocampal lesions in rodents impair both object-place and odor-place associative memory. Subjects with hippocampal damage have impaired associative memory such as object-place memory. Whereas studies have investigated some types of associative memory, no investigation has specifically examined odor-place associative memory in subjects with well-defined amnesia. It is unknown whether amnesic subjects with hippocampal damage would be impaired on an odor-place associative task. We investigated the effect of hippocampal damage in amnesic subjects with hippocampal atrophy on odor-place associative memory and recognition memory tasks. Amnesic and healthy comparison subjects matched for age and education were tested on an odor-place associative task, an odor recognition task, and a place recognition task. The odor-place associative task required subjects to associate 6 odors with 6 spatial locations on a board. The recognition tasks required subjects to identify the 6 odors and the 6 locations that were presented during the associative task. Amnesic subjects were impaired for odor-place memory and place recognition, but not odor recognition compared with comparison subjects. These results suggest that the human hippocampus is necessary for odor-place associative memory and spatial recognition memory. These data provide support for the idea that odor-place associative memory is mediated by the hippocampus in both humans and rodents, suggesting an evolutionary continuity in cognitive function assigned to the hippocampus.
Goodrich-Hunsaker
Naomi J
NJ
1Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA. naomihunsaker@mac.com
Gilbert
Paul E
PE
Hopkins
Ramona O
RO
D000328:Adult; D000647:Amnesia / Q000503:physiopathology; D000818:Animals; D001519:Behavior; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D009812:Odorants; D051381:Rats; D021641:Recognition, Psychology; D012903:Smell / Q000502:physiology*