title: Coagulation disorders in dogs with hepatic disease.
abstract: Liver disease has been associated with abnormalities in haemostasis. In this study, coagulation times, platelet counts, platelet activity parameters, activities of individual coagulation factors, D-dimers, antithrombin (AT) and protein C activity were measured in 42 dogs with histologically confirmed liver disease. Outcome was correlated with histological diagnosis. One or more coagulation abnormalities were present in 57% of dogs with hepatic disease. Activated partial thromboplastin time was significantly prolonged in dogs with chronic hepatitis (CH), with or without cirrhosis. Mean platelet numbers, AT and factor IX activity were significantly lower in dogs with CH plus cirrhosis, compared to dogs with other hepatopathies. D-dimers were not significantly increased in any group. Only three dogs, all with different histological diagnoses, satisfied the criteria for disseminated intravascular coagulation (DIC). Haemostatic abnormalities were primarily seen in dogs with cirrhosis and this may be due to reduced synthesis rather than increased consumption of coagulation factors.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Veterinary Faculty, Utrecht University, P.O. Box 80.154, 3508 TD Utrecht, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Prins
authors.forename: C J M M
authors.initials: CJ
authors.lastname: Schellens
authors.forename: M W
authors.initials: MW
authors.lastname: van Leeuwen
authors.forename: J
authors.initials: J
authors.lastname: Rothuizen
authors.forename: E
authors.initials: E
authors.lastname: Teske
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood / Q000662:veterinary*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D006487:Hemostasis; D008107:Liver Diseases / Q000097:blood / Q000662:veterinary*; D008297:Male; D010314:Partial Thromboplastin Time / Q000662:veterinary; D010976:Platelet Count / Q000662:veterinary; D011446:Prospective Studies; D011517:Prothrombin Time / Q000662:veterinary
chemical_list: D001779:Blood Coagulation Factors