title: The association between the initial end-tidal carbon dioxide difference and the lowest arterial oxygen tension value obtained during one-lung anesthesia with propofol or sevoflurane.
abstract: OBJECTIVE
  The purpose of this study was to examine the correlation between the lowest PaO(2) value recorded during the first 45 minutes of one-lung ventilation (OLV) and the end-tidal CO(2) (ETCO(2)) difference between two-lung ventilation (TLV) and the early phase of OLV.
  
  
  METHODS
  A prospective, randomized study.
  
  
  METHODS
  A university hospital.
  
  
  METHODS
  Thirty-six patients scheduled for elective thoracic surgery.
  
  
  METHODS
  Thoracic surgery patients were randomly assigned to 1 of 2 groups (group P [n = 18], maintained with propofol; group S [n = 18], maintained with sevoflurane). After setting up, the authors measured arterial blood gases at F(I)O(2) = 1.0 as follows: during TLV and at 5 minutes, 15 minutes, 30 minutes, and 45 minutes after the start of OLV. ETCO(2) was recorded just before and at 3 minutes after the start of OLV. The authors examined the relationship between the initial ETCO(2) difference and the lowest PaO(2) value recorded during the first 45 minutes of OLV.
  
  
  RESULTS
  There was a significant negative correlation between the lowest PaO(2) (x) value and the initial ETCO(2) difference (y) during OLV in each group (group P: y = -0.0203x + 7.2571, r(2) = 0.5351; group S: y = -0.0257x + 7.3158, r(2) = 0.6129). This correlation was not significantly different between the groups.
  
  
  CONCLUSIONS
  The present study indicates that the ETCO(2) difference between TLV and early OLV has an association with impaired oxygenation later during OLV. This would be a simple and clinically convenient predictor of the lowest PaO(2) value likely to be reached during one-lung anesthesia with either propofol or sevoflurane.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Naokazu
authors.initials: N
authors.lastname: Fukuoka
authors.forename: Hiroki
authors.initials: H
authors.lastname: Iida
authors.forename: Shigeru
authors.initials: S
authors.lastname: Akamatsu
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Nagase
authors.forename: Hisashi
authors.initials: H
authors.lastname: Iwata
authors.forename: Shuji
authors.initials: S
authors.lastname: Dohi
mesh_terms: D000368:Aged; D000768:Anesthesia, General / Q000379:methods*; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D002245:Carbon Dioxide / Q000097:blood*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D008168:Lung / Q000601:surgery; D008297:Male; D008738:Methyl Ethers; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D015742:Propofol; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods*; D000077149:Sevoflurane; D013223:Statistics as Topic; D013990:Tidal Volume; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D002245:Carbon Dioxide; D000077149:Sevoflurane; D010100:Oxygen; D015742:Propofol