title: Current management of juvenile nasopharyngeal angiofibroma: a tertiary center experience 1999-2007.
abstract: BACKGROUND
  Over the past 10 years, the management of juvenile nasopharyngeal angiofibroma (JNA) has been redefined because of the improvement of transnasal skull base techniques. However, the limits of endoscopic resection still have to be fully defined. The purpose of this study was to report on a series of patients presenting with JNA in an effort to further define an optimal treatment algorithm and improve outcomes.
  
  
  METHODS
  A retrospective review was performed of 18 patients presenting to a tertiary care institution with JNA from 1999 to 2007. Patients were categorized by Andrews stage and data were collected on presentation, operative technique, and postoperative course.
  
  
  RESULTS
  All patients underwent preoperative embolization. Stages 1, 2, and one 3a lesions were approached endoscopically while the remainder underwent open resection. In the endoscopic group the intraoperative blood loss was almost half that of the open group (506 versus 934 mL) and the average hospital stay was 1 day less (3 vs. 4 days).
  
  
  CONCLUSIONS
  Endoscopic resection is reasonable for Andrews stage 1, 2, and select 3a lesions and may allow for less bleeding and a shorter hospital stay. This study supports the current trend of expansion of indications for endoscopic JNA resection.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104-4206, USA. benjamin.bleier@uphs.upenn.edu
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Bleier
authors.forename: David W
authors.initials: DW
authors.lastname: Kennedy
authors.forename: James N
authors.initials: JN
authors.lastname: Palmer
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Chiu
authors.forename: Jason D
authors.initials: JD
authors.lastname: Bloom
authors.forename: Bert W
authors.initials: BW
authors.lastname: O'Malley
mesh_terms: D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000601:surgery*; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D013997:Time Factors