title: Endometrium from women with endometriosis shows increased proliferation activity.
abstract: Examination of 631 infertile women, including 434 women with endometriosis and 197 without endometriosis, revealed an increasing incidence of endometrial polyps, especially in the test subjects with endometriosis, and advanced stages of endometriosis. Expression of Ki-67 and Bcl-2 proteins and MTT assay results were significantly higher in endometrium of patients with endometriosis than in patients without endometriosis. These showed increased proliferation activity and cell proliferation markers not only clinically but also pathologically.
authors.affiliation: Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: Jae Sun
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea; Department of Biological Science, College of Natural Science, Ajou University, Suwon, South Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea. Electronic address: kmr5300@ajou.ac.kr.
authors.forename: Miran
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Chang
authors.affiliation: Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: Kyung Joo
authors.initials: KJ
authors.lastname: Hwang
authors.affiliation: Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: Ki Hong
authors.initials: KH
authors.lastname: Chang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D049109:Cell Proliferation; D004715:Endometriosis / Q000378:metabolism / Q000473:pathology*; D004717:Endometrium / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D011127:Polyps / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D014591:Uterine Diseases / Q000378:metabolism / Q000473:pathology*
chemical_list: D015415:Biomarkers; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2