title: Proteinuria in status epilepticus or eclampsia; a diagnostic dilemma.
abstract: A 36-year-old primigravida with a history of temporal lobe epilepsy presented at 25 weeks of pregnancy with generalized tonic clonic seizures. The clinical picture was confused with eclampsia because of rising blood pressure and proteinuria. Clinical investigations, which included a lumbar puncture, were carried out to rule out an infective cause for the seizures. A computed tomography of the brain was performed for evidence of intracranial hemorrhage. The patient was intubated and ventilated in the intensive care unit. The labile blood pressure settled in 2 days, and the transient heavy proteinuria also resolved after 3 days. Eclampsia would have warranted operative delivery of the preterm fetus with the attendant problems of prematurity. Delivery would have been hazardous in such an acutely unwell patient. The management also would have required magnesium sulfate with its potential for toxicity. Transient proteinuria may occur in status epilepticus. The blood pressure can be labile during epileptic seizures and, in the absence of an intracranial hemorrhage, generally settles without treatment after control of the seizures. This case highlights the importance of differentiating eclampsia in a patient with known epilepsy that may also mask other disease entities such as intracranial hemorrhage, meningitis, or encephalopathy. We have also discussed the importance of various signs associated with eclampsia and their clinical significance. The differential diagnosis of seizures in pregnancy are broad as symptoms of the various disease entities including eclampsia, intracranial hemorrhage, status epilepticus, meningitis, stroke overlap creating a dilemma in an acute emergency. We present a case whereby the clinical picture of status epilepticus was confused with eclampsia because of the presence of a rising blood pressure and proteinuria.
authors.affiliation: Department of Obstetrics and Gynaecology, Northwick Park Hospital, Northwest London NHS Trust, HA1 3UJ London, UK. ensteps@doctors.org.uk
authors.forename: Stephen
authors.initials: S
authors.lastname: Enye
authors.forename: Ramesh
authors.initials: R
authors.lastname: Ganapathy
authors.forename: Omowunmi
authors.initials: O
authors.lastname: Braithwaite
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004461:Eclampsia / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011507:Proteinuria / Q000175:diagnosis*; D013226:Status Epilepticus / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000927:Anticonvulsants