title: FK-506 ointment: an effective adjuvant therapy to treat a dramatic case of pyoderma gangrenosum of unilateral hand.
abstract: Pyoderma gangrenosum (PG) is a cutaneous ulcer developing so rapidly that may mimic a fulminating infection. The correct treatment is nonsurgical, and surgery may get the condition worse.1 FK-506 ointment (0.1% Protopic, Astellas Pharma AG, Fribourg) is usually indicated for inflammatory skin diseases, such as atopic dermatitis and psoriasis2 or for acute rejection reversal of human hand transplantation 3. A few reports of PG affecting the functions of hands can be found in the scientific literature and this report describes the first case treated by FK-506 ointment as an adjuvant therapy.
authors.affiliation: Hand Surgery Unit, Surgical Department, Locarno's Regional Hospital, Via all'Ospedale 1 6600, Locarno, Switzerland. stefano.lucchina@handregistry.com
authors.forename: Stefano
authors.initials: S
authors.lastname: Lucchina
authors.forename: Sandra Leoni
authors.initials: SL
authors.lastname: Parvex
authors.forename: Paul
authors.initials: P
authors.lastname: Biegger
authors.forename: Cesare
authors.initials: C
authors.lastname: Fusetti
mesh_terms: D000368:Aged; D006225:Hand; D006801:Humans; D008297:Male; D009824:Ointments; D017511:Pyoderma Gangrenosum / Q000188:drug therapy* / Q000473:pathology; D016559:Tacrolimus / Q000008:administration & dosage*
chemical_list: D009824:Ointments; D016559:Tacrolimus