Sesquiterpenes with quinone reductase-inducing activity from Liriodendron chinense.
Bioassay-directed separation of the methylene chloride extracts from the wood of Liriodendron chinense led to the isolation of six sesquiterpenes, tulipinolide (1), alpha-liriodenolide (2), beta-liriodenolide (3), lipiferolide (4), 11,13-dehydrolanuginolide (5), and tulipinolide diepoxide (6). Compounds 1-6 have not been found previously in L. chinense. The structures of the compounds were established on the basis of NMR spectroscopic data. All the compounds exhibited quinone reductase (QR)-inducing activity in Hepa lclc7 cells.
Dong
Ying
Y
Department of Oncology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Liang
Dong
D
Huang
Jianjin
J
Zhang
Peng
P
D000818:Animals; D031567:Liriodendron / Q000737:chemistry*; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry; D011808:Quinone Reductases / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014934:Wood / Q000737:chemistry
D010936:Plant Extracts; D012717:Sesquiterpenes; D011808:Quinone Reductases