title: Association analysis between schizophrenia and the AP-3 complex genes.
abstract: A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (chi(2)=6.33, P=0.012, odds ratio=0.80) was no longer positive after correction for multiple testing (corrected P=0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.
authors.affiliation: The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan. hashimor@psy.med.osaka-u.ac.jp
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ohi
authors.forename: Takeya
authors.initials: T
authors.lastname: Okada
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Hidenaga
authors.initials: H
authors.lastname: Yamamori
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hori
authors.forename: Takao
authors.initials: T
authors.lastname: Hikita
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Taya
authors.forename: Osamu
authors.initials: O
authors.lastname: Saitoh
authors.forename: Asako
authors.initials: A
authors.lastname: Kosuga
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tatsumi
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Kamijima
authors.forename: Kozo
authors.initials: K
authors.lastname: Kaibuchi
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kunugi
mesh_terms: D033963:Adaptor Protein Complex 3 / Q000235:genetics*; D033983:Adaptor Protein Complex mu Subunits / Q000235:genetics*; D000328:Adult; D002352:Carrier Proteins / Q000235:genetics; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D033963:Adaptor Protein Complex 3; D033983:Adaptor Protein Complex mu Subunits; D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins