[Expression and significance of IGF-1R and VEGF in gastric carcinoma].
OBJECTIVE
To analyze the expression of IGF-1R and VEGF in human gastric carcinoma, and evaluate the relationship between their expression and tumor's invasion and metastasis.


METHODS
56 cases with gastric carcinoma, 20 cases of atypical hyperplasia tissues of adjacent carcinoma and 28 normal gastric mucosa membrane tissues were examined for the expression of IGF-1R and VEGF by SABC immunohistochemistry.


RESULTS
The positive rates of IGF-1R protein in gastric carcinoma tissues, atypical hyperplasia tissues of adjacent carcinoma and normal gastric mucosa membrane tissues are 87.50%, 55.00% and 17.86%, respectively, and the difference between any two groups was significant (P<0.01); the positive rates of IGF-1R protein in the tissues of metastasis and non-metastasis are 97.06% and 72.73%, respectively(P<0.05); the positive rates of IGF-1R protein in the gastric carcinoma tissues of invaded submucosa, muscular and outer layers are 66.67%, 92.59% and 100%, respectively (P<0.05). The positive rates of VEGF protein in gastric carcinoma tissues, atypical hyperplasia tissues of adjacent carcinoma and normal gastric mucosa are 69.64%, 45.00% and 25.00%, respectively, and the difference between any two groups is significant (P<0.05); the positive rates of VEGF protein in the tissues of metastasis and non-metastasis are 85.29% and 45.45%, respectively (P<0.01); the positive rates of VEGF protein in the gastric carcinoma tissues of invaded submucosa, muscular and outer layers are 40.00%, 74.07% and 85.71%, respectively (P<0.05).


CONCLUSIONS
The results suggest that the expression of IGF-1R or VEGF may be related to the development, invasion and metastasis of gastric carcinoma.
Liu
Wei-dong
WD
Department of Stomach Intestine Surgery in No.1 Peoples Hospital of Huaian, Nanjing Medical University, Huaian 223000, China. lwd1512@yahoo.com.cn
Yu
Ren
R
Zhou
Guan-rong
GR
D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D017526:Receptor, IGF Type 1 / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
D042461:Vascular Endothelial Growth Factor A; D017526:Receptor, IGF Type 1