title: Clinical responses to a mega-dose of vitamin D3 in infants and toddlers with vitamin D deficiency rickets.
abstract: OBJECTIVE
  Was to investigate the effect of treatment with an IM injection, a mega dose of vitamin D3 (10,000 IU/kg) on the clinical, biochemical and radiological parameters of 40 rachitic children with vitamin D deficiency (VDD) over a period of 3 months.
  
  
  METHODS
  In this prospective study we evaluated the clinical, biochemical and radiological responses of an IM injection of cholecalciferol (10,000 IU/kg) for 3 months.
  
  
  RESULTS
  At presentation, the most frequent manifestations were enlarged wrist joints, hypotonia, irritability, cranial bossing, wide anterior fontanel, bow legs, delayed teething and walking and Harrison's sulcus with chest rosaries. Short stature (length SDS < -2) was recorded in 30% of patients. Craniotabes and hypocalcemic tetany were the least common presentations. In VDD children the most frequent biochemical abnormality was high alkaline phosphatase (ALP) (100%), followed by low phosphate (PO(4)) (75%) and low calcium (Ca) (12.5%). One month after treatment, serum Ca, PO(4) and 25(OH)D concentrations were normal. Three months after the injection, serum level of ALP and parathormone (PTH) decreased to normal. The majority of patients (87.5%) had serum 25(OH)D level >or= 20 ng/ml, but some (12.5%) had level <20 ng/ml. Hypercalcemia was not recorded in any patient during the 3-month-period. Significant cure of all symptoms and signs related to vitamin D deficiency had been achieved in all children. Leg bowing showed significant improvement in all patients but was still evident in one third. Complete healing of the radiological evidence of rickets was achieved in 95% of all children.
  
  
  CONCLUSIONS
  An IM injection of a mega dose of cholecalciferol is a safe and effective therapy for treatment of VDD rickets in infants and toddlers with normalization of all the biochemical parameters and healing of radiological manifestations. Measurement of serum 25(OH)D level is highly recommended in all short children with a clear need for a general vitamin D supplementation for all infants and young children in Qatar.
authors.affiliation: Division of Pediatric Endocrinology, Hamad Medical Centre, Doha, Qatar. atsoliman@yahoo.com
authors.forename: Ashraf T
authors.initials: AT
authors.lastname: Soliman
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Dabbagh
authors.forename: Ashraf
authors.initials: A
authors.lastname: Adel
authors.forename: Maryam
authors.initials: M
authors.lastname: Al Ali
authors.forename: Elsaid M
authors.initials: EM
authors.lastname: Aziz Bedair
authors.forename: Rania K
authors.initials: RK
authors.lastname: Elalaily
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D011446:Prospective Studies; D011780:Qatar; D012279:Rickets / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome; D014807:Vitamin D / Q000031:analogs & derivatives; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D050071:Bone Density Conservation Agents; D010281:Parathyroid Hormone; D010710:Phosphates; D014815:Vitamins; D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D002118:Calcium