title: Successful treatment with rituximab in an elderly patient with acquired factor VIII inhibitor.
abstract: We report here on an elderly patient, aged 88 years, who developed acquired hemophilia, with a high titer of factor VIII inhibitors and severe hemorrhage, in the absence of a detectable cause. Marked and prolonged efficacy was observed after rituximab.
authors.affiliation: Department of Geriatrics, Sainte-Marguerite Hospital, Marseille, France. elodie.cretel@ap-hm.fr
authors.forename: Elodie
authors.initials: E
authors.lastname: Cretel
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Jean
authors.forename: Laurent
authors.initials: L
authors.lastname: Chiche
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Durand
mesh_terms: D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D003029:Coagulants / Q000276:immunology / Q000627:therapeutic use; D005169:Factor VIII / Q000276:immunology / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D000069283:Rituximab; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D003029:Coagulants; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D000069283:Rituximab; D005169:Factor VIII