Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE(2), and TNF-alpha production.
Three new phenolic glycosides, salviifosides A-C (13), and three known compounds salicin (4), kaempferol (5), and kaempferol 3-O-beta-d-glucopyranoside (6) were isolated from the leaves of Alangium salviifolium (L.f.) Wangerin (Alangiaceae). The structures of the new metabolites were determined on the basic of spectroscopic analyses including two dimensional NMR. The anti-inflammatory activities of new compounds (1-3) were investigated on lipopolysaccharide (LPS)-induced murine macrophage cells line, RAW 264.7. Salviifoside B (2) potentially inhibits the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), and tumor necrosis factor-alpha (TNF-alpha).
Tran
Manh Hung
MH
College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Republic of Korea.
Nguyen
Hai Dang
HD
Kim
Jin Cheol
JC
Choi
Jae Sue
JS
Lee
Hyeong Kyu
HK
Min
Byung-Sun
BS
D032604:Alangiaceae / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015232:Dinoprostone / Q000378:metabolism*; D006027:Glycosides / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000378:metabolism*; D051379:Mice; D008956:Models, Chemical; D009569:Nitric Oxide / Q000378:metabolism*; D019800:Phenol / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000378:metabolism*; D010946:Plants, Medicinal / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D006027:Glycosides; D008070:Lipopolysaccharides; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D019800:Phenol; D015232:Dinoprostone