[Effects of rphedrine on cardiovascular and renal function of dogs anesthetized with sodium pentobarbital.].
OBJECTIVE
Some studies have shown differentiated dose-dependent effects of ephedrine on cardiovascular and renal functions. This study aimed at verifying whether different ephedrine doses determine differentiated hemodynamic and renal effects.


METHODS
Cardiovascular and renal hemodynamics and renal function were evaluated in 32 dogs anesthetized with sodium pentobarbital (SP) for surgical preparation, catheterization, extracellular fluid volume expansion and mechanical ventilation. Dogs were randomly distributed in four groups: G control (n = 8), in which dogs remained only under the effect of SP; G ephedrine 2 microg (n = 8); G ephedrine 10 microg (n = 8); and G ephedrine 100 microg (n = 8), in which dogs received 2, 10, and 100 microg.kg-1.min-1 ephedrine, respectively. Cardiovascular and renal parameters were studied at control (M1 and M2), during ephedrine infusion (M3 and M4) and after ephedrine infusion withdrawal (M5).


RESULTS
There were no significant differences among groups. There has been a significant increase in heart rate, aortic blood flow, urinary output and fractional sodium excretion in G ephedrine 2 microg. There has been a significant increase in heart rate and filtration fraction in G ephedrine 10 microg while in G ephedrine 100 microg there has been a significant increase in heart rate, mean blood pressure, aortic blood flow, central venous pressure, renal vascular resistance and hematocrit, and a significant decrease in renal plasma and blood flow.


CONCLUSIONS
Our study has shown that ephedrine has differentiated dose-dependent hemodynamic and renal effects.
Amorim
Rosa Beatriz
RB
CET, FMB, UNESP.
Braz
José Reinaldo Cerqueira
JR
Castiglia
Yara Marcondes Machado
YM
Vianna
Pedro Thadeu Galvão
PT
Módolo
Norma Sueli Pinheiro
NS