Resolution of (+/-)-beta-methylphenylethylamine by a novel chiral stationary phase for Pirkle-type column chromatography.
In this study, a new Pirkle-type chiral column stationary phase for resolution of beta-methylphenylethyl amine was described by using activated Sepharose 4B as a matrix, L-tyrosine as a spacer arm, and an aromatic amine derivative of L-glutamic acid as a ligand. The binding capacities of the stationary phase were determined at different pH values (pH = 6, 7, and 8) using buffer solutions as mobile phase, and enantiomeric excess (ee) was determined by HPLC equipped with chiral column. The ee was found to be 47%.
Yilmaz
Hayrullah
H
Department of Chemistry, Faculty of Education, Dicle University, Diyarbakir, Turkey.
Topal
Giray
G
Cakmak
Resit
R
Hosgoren
Halil
H