At loose ends: resecting a double-strand break.
Double-strand break (DSB) repair is critical for maintaining genomic integrity and requires the processing of the 5' DSB ends. Recent studies have shed light on the mechanism and regulation of DNA end processing during DSB repair by homologous recombination.
Bernstein
Kara A
KA
Columbia University Medical Center, Department of Genetics & Development, New York, NY 10032, USA.
Rothstein
Rodney
R
D000818:Animals; D001105:Archaea / Q000378:metabolism; D002453:Cell Cycle; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D006801:Humans