Anti-arthritic potential of the plant Justicia gendarussa Burm F.
OBJECTIVE
To evaluate the anti-arthritic potential of the plant Justicia gendarussa using two different rat models.


METHODS
The anti-arthritic potential of the alcoholic extract of the plant Justicia gendarussa was evaluated using the Freund's adjuvant-induced and collagen-induced arthritic rat models. The rats were treated with the ethanolic extract of Justicia gendarussa and with standard aspirin.


RESULTS
The ethanolic extract of Justicia gendarussa showed significant anti-arthritic activity that was statistically similar to that of aspirin. Our results suggest that the alcoholic extract of Justicia gendarussa exhibits significant anti-arthritic potential.
Paval
Jaijesh
J
Department of Anatomy, Melaka Manipal Medical College, Manipal, Karnataka, India. jaijesh@yahoo.co.in
Kaitheri
Srinivasan Keloth
SK
Potu
Bhagath Kumar
BK
Govindan
Sreejith
S
Kumar
Raju Suresh
RS
Narayanan
Sareesh Naduvil
SN
Moorkoth
Sudheer
S
D027901:Acanthaceae / Q000009:adverse effects; D000276:Adjuvants, Immunologic; D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D002417:Cattle; D024043:Collagen Type II; D004353:Drug Evaluation, Preclinical; D005620:Freund's Adjuvant; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000276:Adjuvants, Immunologic; D024043:Collagen Type II; D010936:Plant Extracts; D005620:Freund's Adjuvant