title: Generalized craving, self-report of arousal, and cue reactivity after brief abstinence.
abstract: BACKGROUND
  Numerous studies report smokers' increased craving and physiological arousal when exposed to cigarette stimuli. These responses are attributed to learning processes (e.g., classical conditioning) and are associated with motivational factors that maintain nicotine dependence. However, much less is known about the degree to which these responses are maintained or diminished during quitting.
  
  
  METHODS
  Treatment-seeking smokers (N = 104) were randomly assigned to continue smoking or to enter a 2-week treatment program. Abstainers (n = 25) were continuously abstinent for 14-17 days at the time of testing. Control subjects (n = 38) continued to smoke at their usual rate. Participants who were assigned to treatment but resumed smoking during the study (n = 41) were considered to be relapsers. Approximately 2 weeks after baseline measurements, abstainers and controls viewed a series of neutral (n = 12) and cigarette (n = 12) pictures, rating them for craving and arousal (feelings of calm vs. excitement).
  
  
  RESULTS
  Non-cued craving (measured during exposure to neutral cues) was diminished in abstaining smokers. However, cigarette cues produced craving increases of the same magnitude in both abstainers and controls, showing that these cues still had evocative power for both groups. Abstaining smokers, who were not physiologically monitored, had lower self-reports of arousal to cigarette pictures than did controls, but the groups did not differ in arousal to neutral pictures.
  
  
  CONCLUSIONS
  These findings suggest that the foundations of cue-induced craving, generalized craving, and physiological arousal associated with craving may arise from separate processes.
authors.affiliation: Department of Behavioral Science, Unit 1330, University of Texas M. D. Anderson Cancer Center, PO Box 301439, Houston, TX 77230-1439, USA. bcarter@mdanderson.org
authors.forename: Brian L
authors.initials: BL
authors.lastname: Carter
authors.forename: Cho Y
authors.initials: CY
authors.lastname: Lam
authors.forename: Jason D
authors.initials: JD
authors.lastname: Robinson
authors.forename: Megan M
authors.initials: MM
authors.lastname: Paris
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Waters
authors.forename: David W
authors.initials: DW
authors.lastname: Wetter
authors.forename: Paul M
authors.initials: PM
authors.lastname: Cinciripini
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001143:Arousal; D016739:Behavior, Addictive / Q000523:psychology*; D003463:Cues; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods*; D011594:Psychometrics; D012907:Smoking / Q000523:psychology*; D016540:Smoking Cessation / Q000523:psychology*; D011795:Surveys and Questionnaires