Effective synthesis of optically active trifluoromethyldiazirinyl homophenylalanine and aroylalanine derivatives with the Friedel-Crafts reaction in triflic acid.
The Friedel-Crafts reaction with 3-(3-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine and optically active N-TFA-Asp(Cl)-OMe in triflic acid afforded homophenylalanine derivatives without any loss of the optical purity.
Murashige
Ryo
R
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
Murai
Yuta
Y
Hatanaka
Yasumaru
Y
Hashimoto
Makoto
M
D000409:Alanine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D008698:Mesylates / Q000737:chemistry*; D013237:Stereoisomerism
D008698:Mesylates; C012077:trifluoromethanesulfonic acid; D000409:Alanine