Obesity genes-it's all about the parents!
Maternal inheritance of mutations in the GNAS1 gene is associated with obesity in humans, but the mechanism involved is unknown. In this issue, Chen et al. (2009) have generated mice with brain specific deletion of either the maternal or paternal allele to trace the origin of the phenotype.
Farooqi
Sadaf
S
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. isf20@cam.ac.uk
D000483:Alleles; D000818:Animals; D004734:Energy Metabolism; D005260:Female; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics* / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008297:Male; D053486:Melanocortins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D044105:Receptor, Melanocortin, Type 4 / Q000172:deficiency / Q000378:metabolism
D020738:Leptin; D053486:Melanocortins; D044105:Receptor, Melanocortin, Type 4; D019205:GTP-Binding Protein alpha Subunits, Gs