title: Use of a single [123I]-FP-CIT SPECT to predict the severity of clinical symptoms of Parkinson disease.
abstract: The aim of this study was to assess the ability of a single SPECT performed in the early stage of Parkinson's disease (PD) to predict disease severity in 19 patients with early PD. [(123)I]-FP-CIT striatal uptake was expressed as a ratio of specific:nonspecific uptake for defined brain areas. Clinical severity was determined by the UPDRS at baseline and 12-15 months following the SPECT procedure. [(123)I]-FP-CIT uptake in the contralateral putamen and striatum was correlated with UPDRS score at baseline, with a more significant correlation after 1-year interval. [(123)I]-FP-CIT uptake in all areas was correlated with bradykinesia and rigidity subscores only at follow up visit. Significant correlations were found between [(123)I]-FP-CIT uptake in the contralateral striatum, putamen and caudate and the difference between motor scores of 1-year interval (DeltaUPDRS). These results suggest that disease severity might be anticipated by a single SPECT at an early stage of the disease.
authors.affiliation: Department of Neurology, Rabin Medical Center, Beilinson Campus, 49100, Petah Tiqwa, Israel. ruthdjal@clalit.org.il
authors.forename: Ruth
authors.initials: R
authors.lastname: Djaldetti
authors.forename: Therese A
authors.initials: TA
authors.lastname: Treves
authors.forename: Ilan
authors.initials: I
authors.lastname: Ziv
authors.forename: Eldad
authors.initials: E
authors.lastname: Melamed
authors.forename: Yair
authors.initials: Y
authors.lastname: Lampl
authors.forename: Mordechai
authors.initials: M
authors.lastname: Lorberboym
mesh_terms: D000328:Adult; D000368:Aged; D020820:Dyskinesias / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000000981:diagnostic imaging / Q000209:etiology; D017072:Neostriatum / Q000000981:diagnostic imaging; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D011699:Putamen / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
chemical_list: D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane