title: Periodontitis is associated with altered plasma fatty acids and cardiovascular risk markers.
abstract: OBJECTIVE
  In periodontitis it has been found that some perturbation exists in lipid biomarkers, such as increased serum total cholesterol and low-density lipoprotein cholesterol. Nevertheless, the relationship between fatty acids and periodontitis has been demonstrated only in a few studies and remains controversial. The aim of this investigation was to explore the effects of periodontitis on a cluster of traditional and novel cardiovascular risk factors such as plasma-lipids profile, types of plasma fatty acids, adhesion molecules and systemic inflammatory markers.
  
  
  RESULTS
  At a university dental school, 56 patients all over 35 years old were enrolled and invited to participate in the study. Total plasma fatty acids, saturated, n-6 polyunsaturated and monounsaturated fatty acids, peroxidability index, soluble VCAM, TNF-alpha, cholesterol, triacylglycerols, and VLDL-c were significantly higher in the periodontitis group compared to the non-periodontitis group.
  
  
  CONCLUSIONS
  This close association found between plasma triacylglycerols, LDL-c, saturated fatty acids, polyunsaturated fatty acids, total amount of fatty acids and coenzyme Q(10) with some periodontal data such as periodontal probing depth, recession of the gingival margin and clinical attachment level (Pearson correlation between 0.3 and 0.6), leads to the conclusion that there is an inter-relationship between periodontitis, plasma fatty acids profile and the increase in metabolic risk factors for cardiovascular diseases.
authors.affiliation: Institute of Nutrition and Food Technology, Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain. mramirez@ugr.es
authors.forename: M C
authors.initials: MC
authors.lastname: Ramirez-Tortosa
authors.forename: J L
authors.initials: JL
authors.lastname: Quiles
authors.forename: M
authors.initials: M
authors.lastname: Battino
authors.forename: S
authors.initials: S
authors.lastname: Granados
authors.forename: J M
authors.initials: JM
authors.lastname: Morillo
authors.forename: S
authors.initials: S
authors.lastname: Bompadre
authors.forename: H N
authors.initials: HN
authors.lastname: Newman
authors.forename: P
authors.initials: P
authors.lastname: Bullon
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D012575:Schools, Dental; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014451:Ubiquinone / Q000097:blood; D015854:Up-Regulation; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D015415:Biomarkers; D015243:Cholesterol, VLDL; D005227:Fatty Acids; D018836:Inflammation Mediators; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; D014451:Ubiquinone; D002784:Cholesterol