Angiotensin-converting enzyme gene insertion/deletion polymorphism in Egyptian patients with myocardial infarction.
BACKGROUND
This work aimed to test the association of the angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism with myocardial infarction.


METHODS
This study comprised 79 Egyptian myocardial infarction cases with a mean age of 54.4+/-9.9 years including 60 males and 19 females, plus 238 healthy unrelated individuals of nearly matched age and sex as a control group. For all subjects, DNA testing for the angiotensin-converting enzyme gene I/D polymorphism was done using PCR amplification for detection of both the D and I alleles followed by a second run PCR specific for the I allele for samples typed as DD in the first run.


RESULTS
Cases had a higher frequency of DD (29.1%) and ID (62.0%) genotypes than II (8.9%) genotype, with a higher frequency of D allele than I allele (64.4% vs. 33.6%). Compared to controls, cases had a significantly higher frequency of ID genotype (62.0% vs. 47.5%, p<0.05).This was more apparent among cases in the low risk group (p=0.002) than in the high risk group (p=0.041).


CONCLUSIONS
The angiotensin-converting enzyme gene I/D polymorphism is probably a risk factor for ischaemic heart disease among Egyptian cases, particularly if integrated with other environmental and genetic risk factors.
Settin
Ahmad
A
Department of Genetics, Faculty of Medicine, Mansoura University, Mansoura, Egypt. settin60@gmail.com
Elbaz
Rizk
R
Abbas
Amr
A
Abd-Al-Samad
Ayman
A
Noaman
Ahmed
A
D000328:Adult; D004534:Egypt; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D009203:Myocardial Infarction / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A