Genetic variant of CCND1: association with HPV-mediated cervical cancer in Indian population.
The potential association of single nucleotide polymorphisms (SNPs) (G870A and G1722C) of CCND1 with susceptibility to cervical cancer was investigated. The study included 200 cervical cancer cases along with an equal number of healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and direct sequencing were employed for genotyping. We found that women carrying the 870AA genotype have a 2.49-fold increased risk for the development of cervical cancer (odds ratio (OR) 2.49; 95% confidence interval (CI) 1.51-4.09; p = 0.0004) compared with GG+GA genotypes. For the 1722 locus, the frequency of the polymorphic 'C' allele was strongly associated with a reduced risk of cervical cancer (p = 0.019; OR 0.71; 95% CI 0.54-0.94). Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer. And G1722C polymorphism may play a protective role against the development of human papillomavirus-associated cervical cancer among Indian women.
Thakur
Nisha
N
Divisions of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology (ICMR), Noida, India.
Hussain
Showket
S
Kohaar
Indu
I
Tabassum
Rubina
R
Nasare
Vilas
V
Tiwari
Pratibha
P
Batra
Swaraj
S
Bhambhani
Suresh
S
Das
Bhudev C
BC
Basir
Seemi Farhat
SF
Bharadwaj
Dwaipayan
D
Bharadwaj
Mausumi
M
D000328:Adult; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D052162:Human papillomavirus 16 / Q000235:genetics*; D006801:Humans; D007194:India; D015810:Linkage Disequilibrium; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000821:virology*
C530104:CCND1 protein, human; D019938:Cyclin D1