title: Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii.
abstract: The study of the chemical constituents of the stem bark of Teclea afzelii (Rutaceae) has resulted in the isolation and characterization of four furoquinoline alkaloids, namely kokusaginine (1), tecleaverdoornine (2), maculine (3) and montrifoline (4) together with lupeol (5) and beta-sitosterol glucopyranoside (6). The structures of the isolated compounds were elucidated based on spectroscopic studies. The antimalarial activity of compounds 1-4 against Plasmodium falciparum in vitro shows partial suppression of parasitic growth.
authors.affiliation: Department of Chemistry, University of Douala, Faculty of Science, Douala, Cameroon.
authors.forename: Jean Duplex
authors.initials: JD
authors.lastname: Wansi
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Alain Tadjong
authors.initials: AT
authors.lastname: Tcho
authors.forename: Simeon F
authors.initials: SF
authors.lastname: Kouam
authors.forename: Sabine
authors.initials: S
authors.lastname: Specht
authors.forename: Salem Ramadan
authors.initials: SR
authors.lastname: Sarite
authors.forename: Achim
authors.initials: A
authors.lastname: Hoerauf
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D004149:Dioxoles; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011804:Quinolines / Q000302:isolation & purification / Q000494:pharmacology*; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D004149:Dioxoles; D005663:Furans; D010936:Plant Extracts; D011804:Quinolines; C505825:maculine; C550313:montrifoline; C550312:tecleaverdoornine; C550311:kokusaginine