[The battle of Silence : action and inhibition of RNA silencing during plant/virus interactions].
RNA silencing is a conserved eukaryotic process mediated by small RNA molecules that inhibit gene expression at the transcriptional, mRNA-stability or translational level through sequence-specific interactions. Diverse roles have been identified for RNA silencing such as genome defense against mobile DNA elements or down-regulation of specific factors during plant and animal development. In plants, RNA silencing plays a crucial role in antiviral defense by inhibiting viral accumulation and sometimes preventing systemic infection. As a counter-defense mechanism, viruses have evolved anti-silencing strategies through the production of viral suppressors of RNA silencing. Here we review the mechanism of RNA silencing and its inhibition during plant/virus interactions and suggest the possible consequences of this molecular arms race on the evolution of both viral and host genomes.
Dunoyer
Patrice
P
Institut de Biologie Moléculaire des Plantes du CNRS, IBMP-CNRS, Université de Strasbourg, France. patrice.dunoyer@ibmp-ulp.u-strasbg.fr
D029681:Arabidopsis Proteins / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D005544:Forecasting; D018506:Gene Expression Regulation, Plant / Q000502:physiology*; D054884:Host-Pathogen Interactions / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics; D008954:Models, Biological; D010935:Plant Diseases / Q000235:genetics / Q000821:virology*; D010942:Plant Viruses / Q000502:physiology*; D010944:Plants / Q000235:genetics* / Q000821:virology; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics; D018749:RNA, Plant / Q000235:genetics*; D034741:RNA, Small Interfering / Q000235:genetics; D043244:Ribonuclease III / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology
D029681:Arabidopsis Proteins; D018797:Cell Cycle Proteins; D035683:MicroRNAs; D012333:RNA, Messenger; D018749:RNA, Plant; D034741:RNA, Small Interfering; D014764:Viral Proteins; C402383:DCL1 protein, Arabidopsis; C519654:DCL3 protein, Arabidopsis; D043244:Ribonuclease III