[Preparation and drug releasing property of curcumin nanoparticles].
OBJECTIVE
To prepare curcumin nanoparticles and evaluate the in vitro release of curcumin.


METHODS
The chitosan-graft-vinyl acetate copolymers were synthesized by free radical polymerization. Curcumin nanoparticles were synthesized by ultrasonic irradiation. The encapsulation efficiency of the nanoparticles and the in vitro release of curcumin were studied.


RESULTS
The nanoparticles were discrete and uniform spheres, covered with positive charges. The encapsulation efficiency of nanoparticles was up to 91.6%. The in vitro release profile showed the slower release rate of curcumin.


CONCLUSIONS
The methods is simple. The nanoparticles possess good physical performance and sustained release character in vitro.
Liu
Zhan-jun
ZJ
School of Science, Tianjin University, Tianjin 300072, China. liuzhanjun815@163.com
Han
Gang
G
Yu
Jiu-gao
JG
Dai
Hong-guang
HG
D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000302:isolation & purification*; D016503:Drug Delivery Systems; D053758:Nanoparticles / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D014465:Ultrasonics
D011108:Polymers; D048271:Chitosan; D003474:Curcumin