title: Absence of M100 source asymmetry in autism associated with language functioning.
abstract: Various clinical populations display atypical volume asymmetry of language structures and also the auditory M100 source. Although such atypical volume asymmetries have also been observed in autism, M100 source asymmetries have not yet been investigated. We examined M100 asymmetry in autism and its relationship with language functioning. Evoked neural activity to a 1 kHz tone was recorded using whole-cortex 151-channel magnetoencephalography in three groups of individuals. A single-dipole model identified the M100 generator in auditory cortex in each hemisphere. Healthy adults and control children displayed the expected right-sided M100 anteriority, whereas children with autism showed no such asymmetry. An association was found between language functioning and the degree of asymmetry across the two groups of children, suggesting a possible relationship between functional-structural asymmetry and language ability.
authors.affiliation: Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA. schmidtg@hope.edu
authors.forename: Gwenda L
authors.initials: GL
authors.lastname: Schmidt
authors.forename: Michael M
authors.initials: MM
authors.lastname: Rey
authors.forename: Janis E
authors.initials: JE
authors.lastname: Oram Cardy
authors.forename: Timothy P L
authors.initials: TP
authors.lastname: Roberts
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000375:Aging; D001303:Auditory Cortex / Q000503:physiopathology; D001307:Auditory Perception / Q000502:physiology*; D001321:Autistic Disorder / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D005072:Evoked Potentials, Auditory; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007802:Language; D007807:Language Tests; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D055815:Young Adult