HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.
(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Wang
Guangyi
G
Discovery Research, InterMune, Inc., Brisbane, CA 94005, USA. gyiwang@yahoo.com
Lei
Huoxing
H
Wang
Xiaofang
X
Das
Debasis
D
Hong
Jian
J
Mackinnon
Colin H
CH
Coulter
Thomas S
TS
Montalbetti
Christian A G N
CA
Mears
Richard
R
Gai
Xinjie
X
Bailey
Sarah E
SE
Ruhrmund
Donald
D
Hooi
Lisa
L
Misialek
Shawn
S
Rajagopalan
P T Ravi
PT
Cheng
Robert K Y
RK
Barker
John J
JJ
Felicetti
Brunella
B
Schönfeld
Dorian L
DL
Stoycheva
Antitsa
A
Buckman
Brad O
BO
Kossen
Karl
K
Seiwert
Scott D
SD
Beigelman
Leonid
L
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology; D001581:Benzothiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D016174:Hepacivirus / Q000378:metabolism; D006526:Hepatitis C / Q000188:drug therapy*; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D012324:RNA-Dependent RNA Polymerase
D000998:Antiviral Agents; D001393:Azoles; D001581:Benzothiadiazines; D004791:Enzyme Inhibitors; D011725:Pyridines; D011743:Pyrimidines; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase