KLRG1--more than a marker for T cell senescence.
The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging indicating that KLRG1 plays an inhibitory role. In this review we examine evidence highlighting this view of KLRG1 with emphasis on the functional defects that arise during T cell differentiation with age that may, in part, be actively maintained by inhibitory receptor signalling.
Henson
Sian M
SM
Division of Infection and Immunity, Department of Immunology, University College London, 46 Cleveland Street, London, UK. s.henson@ucl.ac.uk
Akbar
Arne N
AN
D000375:Aging / Q000276:immunology*; D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D016922:Cellular Senescence / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D037181:Lectins, C-Type / Q000096:biosynthesis*; D010641:Phenotype; D011971:Receptors, Immunologic / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D015534:Trans-Activators / Q000096:biosynthesis*
C113413:KLRG1 protein, human; C451496:Klrg1 protein, mouse; D037181:Lectins, C-Type; D011971:Receptors, Immunologic; D015534:Trans-Activators