Physicochemical properties of magnesium aluminum silicate (smectone) gels prepared using electrolytic-reduction ion water (2): Effects of various salts on the phase diagram.
We produced gels using electrolytic-reduction ion water and magnesium aluminum silicates (smectone), and evaluated in detail gel properties in the presence of various types of salt (NaCl, KCl, CaCl(2), MgCl(2), and AlCl(3)). Each salt was added to deionized-distilled water or electrolytic-reduction ion water, and phase diagrams for the smectone concentration (2.0-4.0%) were produced. The areas of the three phases of smectone (gel, sol, and separation) at each salt concentration were expressed as percentages of the total area. As a result, uni- and polyvalent cations (excluding Ca(2+) ions) affected the stability of gels produced using electrolytic-reduction ion water, and, particularly, univalent cations (Na(+), K(+)) markedly improved gel stability. Using electrolytic-reduction ion water as a dispersal medium, drug delivery systems (DDS) that can maintain the gelling state can be prepared. Thus, gel preparations with maintained functions or controlled-release transdermal drugs can be obtained.
Okajima
Masahiro
M
A. I. System Products Corporation, 281 Kitakaido, Kagiya-cho, Kasugai, Aichi 480-0304, Japan.
Shimokawa
Ken-ichi
K
Ishii
Fumiyoshi
F
D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D002122:Calcium Chloride / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D004572:Electrolysis / Q000379:methods*; D005782:Gels / Q000737:chemistry*; D007477:Ions / Q000737:chemistry*; D015636:Magnesium Chloride / Q000737:chemistry; D017616:Magnesium Compounds / Q000737:chemistry*; D011189:Potassium Chloride / Q000737:chemistry; D017640:Silicates / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry; D014867:Water / Q000737:chemistry*
D017607:Aluminum Compounds; D002712:Chlorides; D005782:Gels; D007477:Ions; D017616:Magnesium Compounds; D017640:Silicates; D015636:Magnesium Chloride; D014867:Water; D000077410:Aluminum Chloride; D012965:Sodium Chloride; D011189:Potassium Chloride; C033065:aluminum magnesium silicate; D002122:Calcium Chloride