Evaluation of exhaled nitric oxide in patients undergoing myocardial revascularization with cardiopulmonary bypass.
OBJECTIVE
Cardiopulmonary bypass (CPB) can cause pulmonary dysfunction. Inflammatory changes may affect the release of nitric oxide (NO). The objective of this study was to evaluate exhaled NO in patients undergoing myocardial revascularization (MR) with CPB.


METHODS
This is a prospective study with nine adult patients undergoing MR with CPB. Initially, air samples were collected to analyze the presence of NO in the system that feeds the anesthesia equipment. Intravenous anesthesia was then initiated with ethomidate (0.3 mg x kg-1), sufentanil (0.3 microg x kg-1), and pancuronium (0.08 mg x kg-1), and maintained with isoflurane (MAC from 0.5 to 1.0) and sufentanil (5 microg x kg-1 x h-1). Tidal volume was fixed at 8 mL.kg-1 and FiO2 0.6, except during CPB. Thirty minutes after induction and 30 minutes after CPB, three sequential samples of exhaled air were collected for NO analysis by chemiluminescence. Data were analyzed by the Student t test.


RESULTS
The level of NO in room air was 5.05 +/- 3.37 ppb. Levels of exhaled NO decreased after CPB, varying from 11.25 +/- 5.65 ppb to 8.37 +/- 3.71 ppb (p = 0.031).


CONCLUSIONS
The reduction of exhaled NO after CPB observed in this study does not confirm the role of this molecule as a marker of pulmonary lesion. However, the different degrees of pulmonary parenchymal collapse, the method used to collect the data, and the drugs, among others, could have contributed for this reduction.
de Amorim
Célio Gomes
CG
Divisão de Anestesia do Instituto Central do HC-FM/USP, Pós-Graduando Nível de Doutorado pelo Programa de Pós-graduação emAnestesiologia da FM/USP.
Sá Malbouisson
Luiz Marcelo
LM
Saraiva
Beatriz Mangueira
BM
Pedro
Fernanda Maria da Silva
FM
Martins
Milton Arruda
MA
Carmona
Maria José Carvalho
MJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001944:Breath Tests; D002315:Cardiopulmonary Bypass; D006801:Humans; D008875:Middle Aged; D009204:Myocardial Revascularization; D009569:Nitric Oxide / Q000032:analysis*; D011446:Prospective Studies; D055815:Young Adult
D009569:Nitric Oxide