Modeling premature brain injury and recovery.
Premature birth is a growing and significant public health problem because of the large number of infants that survive with neurodevelopmental sequelae from brain injury. Recent advances in neuroimaging have shown that although some neuroanatomical structures are altered, others improve over time. This review outlines recent insights into brain structure and function in these preterm infants at school age and relevant animal models. These animal models have provided scientists with an opportunity to explore in depth the molecular and cellular mechanisms of injury as well as the potential of the brain for recovery. The endogenous potential that the brain has for neurogenesis and gliogenesis, and how environment contributes to recovery, are also outlined. These preclinical models will provide important insights into the genetic and epigenetic mechanisms responsible for variable degrees of injury and recovery, permitting the exploration of targeted therapies to facilitate recovery in the developing preterm brain.
Scafidi
Joey
J
Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010, USA.
Fagel
Devon M
DM
Ment
Laura R
LR
Vaccarino
Flora M
FM
D000818:Animals; D001519:Behavior / Q000502:physiology; D001930:Brain Injuries / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D002658:Developmental Disabilities / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature; D023421:Models, Animal; D055495:Neurogenesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology