title: AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans.
abstract: Previous evidence suggests that the dual-specific A kinase-anchoring protein 2 functional polymorphism (AKAP10 (A/G) I646V) influences heart rate (HR) and heart rate variability (HRV) in mice and humans (N=122) with cardiovascular disease. Here, we asked whether this AKAP10 variant predicts HR and HRV in a large sample of healthy humans. Resting HR and short-term time and frequency domain measures of HRV (5 min during paced and unpaced respiration conditions) were assessed in a U.S. community sample (N=1,033) of generally healthy men and women (age 30-54) of European ancestry. Each person was genotyped for the AKAP10 variant. As with previous work, the AKAP10 Val allele predicted greater resting HR (Paced p<.01; Unpaced p<.03) and diminished HRV (Paced ps <.05) suggesting that this variant may modulate the sensitivity of cardiac pacemaker cells to autonomic inputs, possibly conferring risk for arrhythmias and sudden cardiac death.
authors.affiliation: Eastern Virginia Medical School, Norfolk, Virginia 23507, USA. neumansa@evms.edu
authors.forename: Serina A
authors.initials: SA
authors.lastname: Neumann
authors.forename: Whittemore G
authors.initials: WG
authors.lastname: Tingley
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Conklin
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Shrader
authors.forename: Eloise
authors.initials: E
authors.lastname: Peet
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Muldoon
authors.forename: J Richard
authors.initials: JR
authors.lastname: Jennings
authors.forename: Robert E
authors.initials: RE
authors.lastname: Ferrell
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Manuck
mesh_terms: D054758:A Kinase Anchor Proteins / Q000235:genetics*; D000328:Adult; D000483:Alleles; D001341:Autonomic Nervous System / Q000502:physiology; D002304:Cardiac Pacing, Artificial; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006339:Heart Rate / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D012044:Regression Analysis; D014481:United States / Q000453:epidemiology; D044465:White People
chemical_list: D054758:A Kinase Anchor Proteins; C484639:AKAP10 protein, human; D004247:DNA