title: A neuroectodermal hypothesis of the cause and relationship of myopia in retinopathy of prematurity.
abstract: OBJECTIVE
  To analyze the oculometric parameters in preterm infants with and without retinopathy of prematurity (ROP) and to observe the effect of presence of ROP on development of myopia.
  
  
  METHODS
  A prospective study of preterm infants screened for ROP. Examination included fundus examination, cycloplegic refraction, and biometric measurements at three visits.
  
  
  RESULTS
  A total of 42 preterm infants were divided into two groups: preterm infants with ROP and preterm infants without ROP. Preterm infants with ROP who had myopia showed increased lens thickness with similar anterior segment lengths compared to preterm infants without ROP and preterm infants with ROP who did not have myopia.
  
  
  CONCLUSIONS
  Increased lens thickness in the absence of anterior segment arrest seems to be the major contributing factor for myopia in ROP.This change may be associated with altered neuroectodermal development in ROP.
authors.affiliation: Lady Hardinge Medical College, D-38, Malka Ganj, New Delhi, India 110007.
authors.forename: Sarita
authors.initials: S
authors.lastname: Beri
authors.forename: Mridula
authors.initials: M
authors.lastname: Malhotra
authors.forename: Anuradha
authors.initials: A
authors.lastname: Dhawan
authors.forename: Rajiv
authors.initials: R
authors.lastname: Garg
authors.forename: Rajesh
authors.initials: R
authors.lastname: Jain
authors.forename: Pamela
authors.initials: P
authors.lastname: D'souza
mesh_terms: D000869:Anterior Eye Segment / Q000473:pathology; D001699:Biometry; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007908:Lens, Crystalline / Q000473:pathology; D008297:Male; D009216:Myopia / Q000209:etiology* / Q000503:physiopathology*; D054258:Neural Plate / Q000503:physiopathology*; D011446:Prospective Studies; D012029:Refraction, Ocular; D012178:Retinopathy of Prematurity / Q000150:complications* / Q000503:physiopathology