Mechanisms of therapeutic effects of granulocytic colony-stimulating factor in experimental diabetes mellitus.
We studied the mechanisms of therapeutic effects of granulocytic colony-stimulating factor in experimental diabetes mellitus. It was found that this preparation increased the number of mesenchymal precursor cells in the bone marrow and peripheral blood with subsequent increase in the content of progenitor cells in the pancreas. These results attest to mobilization of mesenchymal progenitor cells and their migration into the damaged tissue accompanied by morphofunctional recovery of the insulin-producing apparatus.
Gol'dberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.
Dygai
A M
AM
Zhdanov
V V
VV
Zyuz'kov
G N
GN
Ermakova
N N
NN
Vetoshkina
T V
TV
Fomina
T I
TI
Ermolaeva
L A
LA
Dubskaya
T Yu
TY
D000818:Animals; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D051379:Mice
D016179:Granulocyte Colony-Stimulating Factor