title: Identification of a bioactive compound isolated from Brazilian propolis type 6.
abstract: A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
authors.affiliation: Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), C.P. 52, 13414-903, Piracicaba, SP, Brazil.
authors.forename: Myrella Lessio
authors.initials: ML
authors.lastname: Castro
authors.forename: Andréa Mendes
authors.initials: AM
authors.lastname: do Nascimento
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ikegaki
authors.forename: Cláudio M
authors.initials: CM
authors.lastname: Costa-Neto
authors.forename: Severino M
authors.initials: SM
authors.lastname: Alencar
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Rosalen
mesh_terms: D000190:Actinomyces / Q000187:drug effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D001422:Bacterial Adhesion / Q000187:drug effects; D001516:Bees / Q000378:metabolism; D001577:Benzophenones / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D001938:Brazil; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D009154:Mutation; D054876:Prenylation; D011429:Propolis / Q000737:chemistry*; D013210:Staphylococcus / Q000187:drug effects / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001577:Benzophenones; D011429:Propolis