Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study.
OBJECTIVE
To compare blood flow measurements of tumors assessed by perfusion computed tomography (pCT) and the clinical gold standard of 15O-labeled water positron emission tomography (15O-PET).


METHODS
Blood flows were estimated by pCT (4-row multidetector, CT Perfusion 3.1) and 15O-PET (Posicam, first-pass model) in 14 patients with solid tumors, totaling 22 index tumors and 57 matched pairs of examinations. Blood flow estimates were compared using t test, Bland-Altman, and linear mixed regression analyses.


RESULTS
There was no significant difference between the mean (SD) blood flow values measured by pCT and 15O-PET: 25.9 +/- 15.4 and 27.8 +/- 14.0 mL/min per 100 g, respectively.


CONCLUSIONS
The demonstration of a good correlation between pCT and 15O-PET potentially enables the use of pCT, which is more widely available than 15O-PET, when tumor blood flow estimates are required, particularly in the context of clinical studies.
Ng
Chaan S
CS
Department of Radiology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4009, USA. cng@mdanderson.org
Kodama
Yoshihisa
Y
Mullani
Nizar A
NA
Barron
Bruce J
BJ
Wei
Wei
W
Herbst
Roy S
RS
Abbruzzese
James L
JL
Charnsangavej
Chusilp
C
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001783:Blood Flow Velocity; D005260:Female; D006801:Humans; D007553:Isotope Labeling; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000517:prevention & control; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014867:Water
D000970:Antineoplastic Agents; D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals; D014867:Water