Fast and easy access to efficient bifunctional chelators for MRI applications.
Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The Gd(III) complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported.
Gugliotta
Giuseppe
G
Dipartimento di Scienze dell'Ambiente e della Vita, Università degli Studi del Piemonte Orientale A. Avogadro, Viale T. Michel 11, 15121 Alessandria, Italy.
Botta
Mauro
M
Giovenzana
Giovanni Battista
GB
Tei
Lorenzo
L
D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry*; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D008279:Magnetic Resonance Imaging
C511496:6-amino-6-methylperhydro-1,4-diazepine; D001381:Azepines; D002614:Chelating Agents; D003287:Contrast Media; D005682:Gadolinium