Radiation-induced mammary carcinogenesis in rodent models: what's different from chemical carcinogenesis?
Ionizing radiation is one of a few well-characterized etiologic factors of human breast cancer. Laboratory rodents serve as useful experimental models for investigating dose responses and mechanisms of cancer development. Using these models, a lot of information has been accumulated about mammary gland cancer, which can be induced by both chemical carcinogens and radiation. In this review, we first list some experimental rodent models of breast cancer induction. We then focus on several topics that are important in understanding the mechanisms and risk modification of breast cancer development, and compare radiation and chemical carcinogenesis models. We will focus on the pathology and natural history of cancer development in these models, genetic changes observed in induced cancers, indirect effects of carcinogens, and finally risk modification by reproductive factors and age at exposure to the carcinogens. In addition, we summarize the knowledge available on mammary stem/progenitor cells as a potential target of carcinogens. Comparison of chemical and radiation carcinogenesis models on these topics indicates certain similarities, but it also indicates clear differences in several important aspects, such as genetic alterations of induced cancers and modification of susceptibility by age and reproductive factors. Identification of the target cell type and relevant translational research for human risk management may be among the important issues that are addressed by radiation carcinogenesis models.JRRS Incentive Award in 2009.
Imaoka
Tatsuhiko
T
Experimental Radiobiology for Children's Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Japan. t_imaoka@nirs.go.jp
Nishimura
Mayumi
M
Iizuka
Daisuke
D
Daino
Kazuhiro
K
Takabatake
Takashi
T
Okamoto
Mieko
M
Kakinuma
Shizuko
S
Shimada
Yoshiya
Y
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004195:Disease Models, Animal; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000209:etiology* / Q000503:physiopathology*; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000503:physiopathology*; D051381:Rats
D002273:Carcinogens