title: [Safety and efficacy of purified human C1-esterase inhibitor in the treatment of patients with sepsis].
abstract: One of the new experimental trends in pharmacotherapy of sepsis is the use of C1-esterase inhibitor (C1I) from the group of immunobiological agents influencing the complement system. An open prospective study on the safety and efficacy of C1I revealed its positive effect on the death rate among the patients with sepsis. In a dose of 12000 IU, C1I had a significant inhibitory action on the complement system activity, as well as an antiinflammatory effect by blocking the complement-dependent link in the systemic inflammation. The adverse and significant adverse events were not associated with the use of C1I.
authors.forename: N B
authors.initials: NB
authors.lastname: Lazareva
authors.forename: A A
authors.initials: AA
authors.lastname: Igonin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D050718:Complement C1 Inhibitor Protein / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use*; D003176:Complement C3 / Q000032:analysis / Q000037:antagonists & inhibitors; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D050718:Complement C1 Inhibitor Protein; D003176:Complement C3