title: Isolation, structure elucidation and apoptosis-inducing activity of new compounds from the edible fungus Lentinus striguellus.
abstract: Three new natural compounds, striguellolide A (1), striguellol A (2) and striguellone A (6), together with three known ones, 3,4-trans-dihydroxy-6-methoxy-2,2-dimethylchroman (3), 3-hydroxy-6- methoxy-2,2-dimethylchroman-4-one (4) and 3-hydroxy-6- methoxy-2,2-dimethylchroman (5), were isolated from the agar cultures of the edible fungal strain Lentinus striguellus. Their structures were elucidated by spectroscopic and mass spectrometric analyses, including 1D-, 2D-NMR and HR-ESI-Q-TOF-MS, and chemical reactions. Striguellone A showed cytotoxicity against HeLa cells by MTT assay and was found to be an activator of apoptosis, assessed by morphological observation and cell cycle analysis using the flow cytometer.
authors.affiliation: Institute of Soil and Fertilizer, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, P. R. China.
authors.forename: Yongbiao
authors.initials: Y
authors.lastname: Zheng
authors.forename: Baobing
authors.initials: B
authors.lastname: Zhao
authors.forename: Chunhua
authors.initials: C
authors.lastname: Lu
authors.forename: Xinjian
authors.initials: X
authors.lastname: Lin
authors.forename: Zhonghui
authors.initials: Z
authors.lastname: Zheng
authors.forename: Wenjin
authors.initials: W
authors.lastname: Su
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D020074:Lentinula / Q000737:chemistry*; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D009930:Organic Chemicals / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D009930:Organic Chemicals