title: A review of repeat prostate biopsies and the influence of technique on cancer detection: our experience.
abstract: BACKGROUND
  Follow-up of patients with an initial negative prostate biopsy, but surrounding whom a suspicion of prostate cancer persists, is difficult. In addition, debate exists as to the optimal technique for repeat prostate biopsy.
  
  
  OBJECTIVE
  To assess the cancer detection rate on repeat prostate biopsy.
  
  
  METHODS
  We reviewed patients who underwent prostate biopsy in our department in 2005 who had >or=1 previous biopsy within the preceding 5 years. Cancer detection rate on repeat biopsy and the influence of the number of biopsy cores were recorded.
  
  
  RESULTS
  Cancer detection rate on repeat biopsy was 15.4%, with approximately 60% detected on the first repeat biopsy, but approximately 10% not confirmed until the fourth repeat biopsy. Gleason score was similar regardless of the time of diagnosis (6.1-6.5). Mean interval between first biopsy and cancer diagnosis (range 18-55 months) depended on the number of repeat procedures. There was an association between the number of biopsy cores and cancer detection.
  
  
  CONCLUSIONS
  This study supports the practice of increasing the number of cores taken on initial and first repeat biopsy to maximise prostate cancer detection and reduce the overall number of biopsies needed.
authors.affiliation: Department of Urology, The Adelaide and Meath Hospital incorporating the National Children's Hospital, Tallaght, Dublin 24, Ireland.
authors.forename: M R
authors.initials: MR
authors.lastname: Quinlan
authors.forename: R G
authors.initials: RG
authors.lastname: Casey
authors.forename: R
authors.initials: R
authors.lastname: Flynn
authors.forename: R
authors.initials: R
authors.lastname: Grainger
authors.forename: T E D
authors.initials: TE
authors.lastname: McDermott
authors.forename: J A
authors.initials: JA
authors.lastname: Thornhill
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D020728:Transurethral Resection of Prostate
chemical_list: D017430:Prostate-Specific Antigen