Circulating sTWEAK improves the prediction of coronary artery disease.
OBJECTIVE
Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance.


METHODS
The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects.


RESULTS
Serum sTWEAK concentrations were significantly lower in the patients (534.5+/-110.9 microg/L) than in the controls (688.1+/-150.0 microg/L, p<0.001), even after adjusting for different confounders (p<0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p=0.011-0.035).


CONCLUSIONS
The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers.
Jelić-Ivanović
Zorana
Z
Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. zorana.jelic@pharmacy.bg.ac.rs
Bujisić
Nada
N
Spasić
Slavica
S
Bogavac-Stanojević
Natasa
N
Spasojević-Kalimanovska
Vesna
V
Kotur-Stevuljević
Jelena
J
D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D000074049:Cytokine TWEAK; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D048069:Tumor Necrosis Factors / Q000097:blood*
D015415:Biomarkers; D000074049:Cytokine TWEAK; C109743:TNFSF12 protein, human; D048069:Tumor Necrosis Factors