Squamous cell carcinoma of the nasal vestibule 1993-2002: a nationwide retrospective study from DAHANCA.
BACKGROUND
A retrospective nationwide study of cancer of the nasal vestibule was conducted to evaluate classification systems and prognostic factors for treatment outcome.


METHODS
Patients treated between 1993 and 2002 at head and neck oncology centers in Denmark were included.


RESULTS
The 5-year results were locoregional control 67%, overall survival 50%, cancer-specific survival 74%. Cancer-specific survival according to Wang classification was 83%, 63%, and 39% for T1, T2, T3, respectively (p < .000). Regarding T1 tumors, 5-year locoregional control for surgery, surgery + radiotherapy (RT), or RT was 94%, 87%, or 61%, respectively (p < .000). Fifty-four Gray in 18 fractions was found comparable with 66 Gy in 33 fractions regarding T1 tumors.


CONCLUSIONS
This national survey is the largest series of nasal vestibule cancer ever published. Wang classification is more prognostic and easier to use than the Union Internationale Contre le Cancer 2002. Surgery or hypofractionated RT can be used for T1 lesions, whereas larger lesions should be treated with combined approach.
Agger
Andreas
A
Department of Otolaryngology, Head and Neck Surgery, Aarhus University Hospital, 44 Noerrebrogade, Aarhus, Denmark. a.agger@dadlnet.dk
von Buchwald
Christian
C
Madsen
Anders Rørbaek
AR
Yde
Jesper
J
Lesnikova
Iana
I
Christensen
Charlotte Birk
CB
Foghsgaard
Søren
S
Christensen
Thomas Broe
TB
Hansen
Hanne Sand
HS
Larsen
Susanne
S
Bentzen
Jens
J
Andersen
Elo
E
Andersen
Lisbeth
L
Grau
Cai
C
D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D015331:Cohort Studies; D003131:Combined Modality Therapy; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000145:classification / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D011336:Probability; D018714:Radiotherapy, Adjuvant; D012016:Reference Values; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome