Action of propranolol in the reaction of smooth musculature of tracheal rings induced with acetylcholine, histamine, serotonin (5-HT) and prostaglandin (PGF2-alfa) in vitro and in vivo.
Actions of acetylcholine (ACh), histamines, serotonins (5-HT) and prostaglandins (PGF2-alfa) in concentrations of 10(-4), 10(-3), 10(-2) and 10(-1) mol/dm(3) were analyzed in vitro conditions in isolated specimens of tracheas of 24 pigs, 7 guinea pigs, and dead persons for different reasons (8), in the presence and without presence of propranolol. Whilst, research regarding actions of aerosolized histamines (10 mg, 1%, 2 min), in the presence and without the presence of aerosolized propranolol (20 mg, 2%, 2 min) was done in vivo in 6 healthy persons. Study results show that propranolol does not emphasize contraction of the airways smooth musculature as induced by ACh, histamine, 5-HT and PGF2-alfa in vitro conditions (p>0,1). Also, in vivo we found a non-significance of tracheal smooth musculature constriction (p>0,1).
Islami
Hilmi
H
Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N., Prishtina, Kosovo.
Bexheti
Sadi
S
Ahmetaj
Halil
H
Sukalo
Aziz
A
Manxhuka
Suzana
S
Nuraj
Bajram
B
Kamberi
Xhevat
X
Krasniqi
Shaip
S
Qorraj
Hasime
H
Kastrati
Bashkim
B
Disha
Mentor
M
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D015237:Dinoprost / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D013552:Swine
D012701:Serotonin; D006632:Histamine; D011433:Propranolol; D015237:Dinoprost; D000109:Acetylcholine