Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii.
The study of the chemical constituents of the stem bark of Teclea afzelii (Rutaceae) has resulted in the isolation and characterization of four furoquinoline alkaloids, namely kokusaginine (1), tecleaverdoornine (2), maculine (3) and montrifoline (4) together with lupeol (5) and beta-sitosterol glucopyranoside (6). The structures of the isolated compounds were elucidated based on spectroscopic studies. The antimalarial activity of compounds 1-4 against Plasmodium falciparum in vitro shows partial suppression of parasitic growth.
Wansi
Jean Duplex
JD
Department of Chemistry, University of Douala, Faculty of Science, Douala, Cameroon.
Hussain
Hidayat
H
Tcho
Alain Tadjong
AT
Kouam
Simeon F
SF
Specht
Sabine
S
Sarite
Salem Ramadan
SR
Hoerauf
Achim
A
Krohn
Karsten
K
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D004149:Dioxoles; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011804:Quinolines / Q000302:isolation & purification / Q000494:pharmacology*; D027821:Rutaceae / Q000737:chemistry*
D000470:Alkaloids; D000962:Antimalarials; D004149:Dioxoles; D005663:Furans; D010936:Plant Extracts; D011804:Quinolines; C505825:maculine; C550313:montrifoline; C550312:tecleaverdoornine; C550311:kokusaginine