Hirtellanines A and B, a pair of isomeric isoflavonoid derivatives from Campylotropis hirtella and their immunosuppressive activities.
A pair of isomeric isoflavonoid derivatives, Hirtellanines A (1) and B (2), has been isolated from the roots of Campylotropis hirtella (Franch.) Schindl. and their structures were elucidated on the basis of spectroscopic methods, with special emphasis on 1D and 2D NMR techniques. The in vitro assay showed that Hirtellanine A had strong B lymphocyte suppression activity (IC(50): 0.06microM) and T lymphocyte suppression activity (IC(50): 0.92microM). Hirtellanine B showed moderate B lymphocyte suppression activity (IC(50): 3.00microM) and T lymphocyte suppression activity (IC(50): 9.55microM). Due to the potent immunosuppressive activities and lower cytotoxicity, Hirtellanine A could be a promising lead towards novel immunosuppressive agents.
Shou
Qing Yao
QY
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
Tan
Qing
Q
Shen
Zheng Wu
ZW
D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D007887:Fabaceae / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D007166:Immunosuppressive Agents; D007529:Isoflavones; C542852:hirtellanine A; C542853:hirtellanine B