title: A novel physiological investigation of the functional residual capacity by the bias flow nitrogen washout technique in infants.
abstract: The dynamic functional residual capacity (FRC(dyn)), the lung volume most routinely measured in infants, is an unreliable volume landmark. In addition to the FRC(dyn), we measured the (passive) static FRC (FRC(st)) by inducing a brief post-hyperventilation apnea (PHA) in 33 healthy infants aged 7.4-127.2 weeks. A commercial system for nitrogen (N2) washout to measure FRC, and a custom made system to monitor and record flow and airway opening pressure signals in real-time were used in unison. Infants were manually hyperventilated to induce a PHA. After the last passive expiration, FRC(st) was estimated by measuring the volume of N2 expired after end-passive expiratory switching of the inspired gas from room air to 100% oxygen during the post-expiratory apneic pause. Repeatable intrasubject FRC(st) and FRC(dyn) measurements overlapped in most infants including the younger ones (P = 0.2839). Mean (95% confidence interval [CI]) FRC(st) was 21.1 (20.0-22.3), and error-corrected FRC(dyn) was 21.4 (20.4-22.4) ml/kg. Mean (washout time [t]) tFRC(st) was longer than tFRC(dyn) 60 sec (95% CI 55-65) versus 47 sec (95% CI 43-51) (P < 0.0001). The FRC and washout time were dependent on body length, weight and age. We conclude that the FRC(st) is not different from the FRC(dyn) in infants. The FRC(st) is a reliable volume landmark because the PHA stabilizes the end-expiratory level by potentially abolishing the sedated infant's breathing strategies. The FRC(st) lacks potential sources of errors and disadvantages associated with measuring the FRC(dyn). The findings cast significant doubt on the traditional physiology of air trapping in healthy infants' lungs.
authors.affiliation: Department of Pediatrics, Pulmonary Medicine Section, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, 1 Children's Way, Slot 512-17, Little Rock, AR 72202, USA. morrismohyg@uams.edu
authors.forename: Mohy G
authors.initials: MG
authors.lastname: Morris
mesh_terms: D002675:Child, Preschool; D005652:Functional Residual Capacity; D006801:Humans; D006985:Hyperventilation; D007223:Infant; D009584:Nitrogen; D012129:Respiratory Function Tests / Q000379:methods*
chemical_list: D009584:Nitrogen