title: Drug hypersensitivity syndrome induced by meglumine antimoniate.
abstract: We report a case of drug hypersensitivity syndrome (drug reaction with eosinophilia and systemic symptoms [DRESS]) induced by parenteral meglumine antimoniate (Glucantime) in a 40-year-old man who traveled to Bolivia and was treated for mucocutaneous leishmaniasis. Two weeks after starting therapy, the patient had fever, joint pain, a cutaneous eruption, and hypereosinophilia (1,358 cells/mm(3)). These symptoms resolved after drug withdrawal but reappeared upon reintroduction of the drug. Pentavalent antimonials should be definitively withdrawn in patients with hypereosinophilia > 1,000 cells/mm(3) accompanied by systemic manifestations consistent with DRESS.
authors.affiliation: Service de Parasitologie-Mycologie, et Service de Maladies Infectieuses et Tropicales, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. fakhri.jeddi@gmail.com
authors.forename: Fakhri
authors.initials: F
authors.lastname: Jeddi
authors.forename: Eric
authors.initials: E
authors.lastname: Caumes
authors.forename: Marc
authors.initials: M
authors.lastname: Thellier
authors.forename: Stéphane
authors.initials: S
authors.lastname: Jauréguiberry
authors.forename: Dominique
authors.initials: D
authors.lastname: Mazier
authors.forename: Pierre A
authors.initials: PA
authors.lastname: Buffet
mesh_terms: D000328:Adult; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity; D006801:Humans; D007897:Leishmaniasis, Mucocutaneous / Q000188:drug therapy; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate