title: Successful perinatal outcome in an early onset intrahepatic cholestasis of pregnancy with extremely high serum hepatic function tests.
abstract: We report a case of a 21-year-old pregnant woman with an early onset of intrahepatic cholestasis of pregnancy with very high aminotransferases activity and bilirubin concentration. Viral and autoimmune hepatitis, and other possible causes of liver function impairment were excluded. Treatment with ursodeoxycholic acid improved biochemical markers. The patient delivered a healthy female neonate by caesarean section. Neonatal and postoperative courses were uneventful.
authors.affiliation: Second Department of Obstetrics and Gynecology, Warsaw Medical University, Warsaw 00-315, Poland.
authors.forename: Roman
authors.initials: R
authors.lastname: Smolarczyk
authors.forename: Monika
authors.initials: M
authors.lastname: Grymowicz
authors.forename: Jacek
authors.initials: J
authors.lastname: Sienko
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Czajkowski
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002780:Cholestasis, Intrahepatic / Q000209:etiology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008111:Liver Function Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D011256:Pregnancy Outcome; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin