title: Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes.
abstract: Among lifestyle-related factors, low to moderate alcohol drinking has been proposed as a protective factor against the development of age-related changes in cognitive function, predementia syndromes, and cognitive decline of degenerative (Alzheimer's disease, AD) or vascular origin (vascular dementia, VaD) in several longitudinal studies, but contrasting findings also exist. Furthermore, many of these studies were limited by cross-sectional design, restriction by age or sex, or incomplete ascertainment. Different outcomes, beverages, drinking patterns, or follow-up periods, or possible interactions with other lifestyle-related (i.e., smoking) or genetic factors [i.e., apolipoprotein E (APOE) genotyping] may be sources of great variability. Light to moderate alcohol use may be associated with a reduced risk of unspecified incident dementia and AD, while for VaD, cognitive decline, and predementia syndromes, the current evidence is only suggestive of a protective effect. In conclusion, as intervention studies are not feasible in this area, the best evidence comes from an overview of epidemiological studies, suggesting that the protective effects are more likely with wine consumption and the absence of an APOE e4 allele. At present, there is no indication that light to moderate alcohol drinking would be harmful to cognition and dementia, and it is not possible to define a specific beneficial level of alcohol intake.
authors.affiliation: Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Panza
authors.forename: Cristiano
authors.initials: C
authors.lastname: Capurso
authors.forename: Alessia
authors.initials: A
authors.lastname: D'Introno
authors.forename: Anna M
authors.initials: AM
authors.lastname: Colacicco
authors.forename: Vincenza
authors.initials: V
authors.lastname: Frisardi
authors.forename: Maria
authors.initials: M
authors.lastname: Lorusso
authors.forename: Andrea
authors.initials: A
authors.lastname: Santamato
authors.forename: Davide
authors.initials: D
authors.lastname: Seripa
authors.forename: Alberto
authors.initials: A
authors.lastname: Pilotto
authors.forename: Emanuele
authors.initials: E
authors.lastname: Scafato
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Vendemiale
authors.forename: Antonio
authors.initials: A
authors.lastname: Capurso
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Solfrizzi
mesh_terms: D000375:Aging; D000428:Alcohol Drinking / Q000523:psychology*; D000818:Animals; D003072:Cognition Disorders / Q000209:etiology*; D003704:Dementia / Q000150:complications* / Q000523:psychology*; D018450:Disease Progression; D006801:Humans; D008019:Life Style