The dominance of China 1 in the spectrum of Epstein-Barr virus strains from Cantonese patients with nasopharyngeal carcinoma.
Nasopharyngeal carcinoma is a disease with a remarkable geographic and ethnic distribution, and has a high incidence in southern China. Infection with Epstein-Barr virus (EBV) is an important contributing factor. The profile of EBV strains in Cantonese patients from Guangdong, the nasopharyngeal carcinoma endemic region in southern China, is described on the sequence variations in latent membrane protein 1 carboxyl-terminus. The results show that China 1 was the dominant EBV strain detected in both the tumor biopsies and samples of throat washings, whereas multiple strains, including China 1, China 2, B95-8, and Med, were detected in blood samples. In addition, a new strain named China 4 was found in blood samples. These findings suggest that the host population is susceptible to the predominant China 1 strain in the nasopharyngeal carcinoma endemic region of China, but its relationship with the host remains to be characterized further.
Li
Da-Jiang
DJ
State Key Laboratory of Oncology in Southern China, Guangzhou, China.
Bei
Jin-Xin
JX
Mai
Shi-Juan
SJ
Xu
Jin-Fen
JF
Chen
Li-Zhen
LZ
Zhang
Ru-Hua
RH
Yu
Xing-Juan
XJ
Hong
Ming-Huang
MH
Zeng
Yi-Xin
YX
Kang
Tiebang
T
D001769:Blood / Q000821:virology; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D019353:Endemic Diseases; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000821:virology*; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000821:virology*; D010614:Pharynx / Q000821:virology; D017422:Sequence Analysis, DNA; D014763:Viral Matrix Proteins / Q000235:genetics
D004279:DNA, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins