title: Percutaneous implantation of autologous bone marrow osteoprogenitor cells as treatment of bone avascular necrosis related to sickle cell disease.
abstract: The treatment of bone a vascular necrosis is a big challenge considering the youthfulness of the patients involved by necrosis in sickle cell disease and the importance of the generated disability. A vascular osteonecrosis is an epiphysis pathology which could be treated by joint replacement with success, however, multiple surgical procedures are mostly necessary during the patient's life with a hazardous long term functional results. The treatment by autologous bone marrow grafting is an effective alternative which preserve the native joint. Using this mini-invasive high technology surgical treatment in early stages, a joint replacement could be avoided in many patients.
authors.affiliation: Department of Orthopaedic Surgery, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 cedex Créteil, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Hernigou
authors.forename: Gilsasio
authors.initials: G
authors.lastname: Daltro
authors.forename: Paolo
authors.initials: P
authors.lastname: Filippini
authors.forename: Martin Mukisi
authors.initials: MM
authors.lastname: Mukasa
authors.forename: Olivier
authors.initials: O
authors.lastname: Manicom