title: Human papillomavirus genotypes and phylogenetic analysis of HPV-16 variants in HIV-1 infected subjects in Italy.
abstract: A cross-sectional study was carried out to improve the state of evidence regarding the spectrum of HPV types and HPV-16 LCR variants circulating among men and women infected with HIV-1 in Italy. This study, conducted in 518 HIV-positive subjects (346 males and 172 females), showed a high prevalence of HPV anal infections (88.7%) in men and of cervical infections (65.1%) in women. A wide spectrum of HPV genotypes has been observed, as both single and multiple infections. Low-risk HPV types 6, 11 and 61 were frequently detected. HPV-16 was the prevalent high-risk type. Fourteen different HPV-16 LCR variants were found. Ten belonged to the European lineage (78.7% were detected in Italian subjects and 21.3% in foreign-born, all homo/bisexual men), two to the Asiatic lineage and two to the African-2 lineage. This study underlines the great genotypic heterogeneity characterizing anal and cervical HPV infections and the marked polymorphism of the predominant HPV-16 in this high-risk population in Italy.
authors.affiliation: University of Milan, Department of Public Health-Microbiology-Virology, Via Pascal 36/38, 20133 Milan, Italy. elisabetta.tanzi@unimi.it
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Tanzi
authors.forename: Antonella
authors.initials: A
authors.lastname: Amendola
authors.forename: Silvia
authors.initials: S
authors.lastname: Bianchi
authors.forename: M Michela
authors.initials: MM
authors.lastname: Fasolo
authors.forename: Rosangela
authors.initials: R
authors.lastname: Beretta
authors.forename: Elena
authors.initials: E
authors.lastname: Pariani
authors.forename: Alessandra
authors.initials: A
authors.lastname: Zappa
authors.forename: Elena
authors.initials: E
authors.lastname: Frati
authors.forename: Giovanna
authors.initials: G
authors.lastname: Orlando
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1; D052162:Human papillomavirus 16 / Q000235:genetics*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D010802:Phylogeny; D011110:Polymorphism, Genetic; D015995:Prevalence
chemical_list: D004279:DNA, Viral