title: Lobarialides A-C, antifungal triterpenoids from the lichen Lobaria kurokawae.
abstract: Three novel fernane-type triterpenoids, lobarialides A-C (1-3, resp.), together with two known ones were isolated by antifungal bioassay-guided fractionation of the lichen Lobaria kurokawae. Their structures including configurations were established on the basis of extensive spectroscopic analyses, and that of 1 was confirmed by a single-crystal X-ray diffraction analysis. Antifungal tests of the five triterpenoids showed that the activity increased with the increment of the number of COO groups.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan, P. R. China.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Hai-Juan
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Ren
authors.forename: Mei
authors.initials: M
authors.lastname: Ji
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Yu
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D008011:Lichens / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000935:Antifungal Agents; D014315:Triterpenes; C542665:lobarialide A; C542666:lobarialide B; C542667:lobarialide C