title: Isolated ovarian relapse of pre-B acute lymphoblastic leukemia: a case report.
abstract: BACKGROUND
  Acute lymphoblastic leukemia is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace normal marrow hematopoietic cells, resulting in a marked decrease in the production of normal blood cells.
  
  
  METHODS
  We report a case of isolated ovarian relapse 7 years after the primary diagnosis in a patient, who was seemingly in clinical remission following unilateral ovariectomy and second-line chemotherapy.
  
  
  CONCLUSIONS
  In contrast to testicular relapse, ovarian relapses in acute lymphoblastic leukemia are rarely reported. Surgical removal of the mass followed by chemotherapy is the therapeutic standard.
authors.affiliation: Department of Obstetrics and Gynecology, University of Parma, Parma via gramsci 14 -43100, Italy. rberretz@tin.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Berretta
authors.forename: Angelica
authors.initials: A
authors.lastname: Barone
authors.forename: Martino
authors.initials: M
authors.lastname: Rolla
authors.forename: Patrizia
authors.initials: P
authors.lastname: Bertolini
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Nardelli
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D010052:Ovariectomy; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery