title: NPR1 in Plant Defense: It's Not over 'til It's Turned over.
abstract: NPR1 is a key transcriptional coregulator in plant defense responses. In this issue, Spoel et al. (2009) demonstrate that proteasome-mediated degradation of NPR1 in the nucleus promotes efficient expression of defense response genes following infection and prevents spurious activation of defensive responses in the absence of infection.
authors.affiliation: Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: M Shahid
authors.initials: MS
authors.lastname: Mukhtar
authors.forename: Marc T
authors.initials: MT
authors.lastname: Nishimura
authors.forename: Jeff
authors.initials: J
authors.lastname: Dangl
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000276:immunology*; D029681:Arabidopsis Proteins / Q000276:immunology* / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; C105496:NPR1 protein, Arabidopsis; D046988:Proteasome Endopeptidase Complex