New tools for functional genomic analysis.
For the past decade, the development of genomic technology has revolutionized modern biological research and drug discovery. Functional genomic analyses enable biologists to perform analysis of genetic events on a global scale and they have been widely used in gene discovery, biomarker determination, disease classification, and drug target identification. In this article, we provide an overview of the current and emerging tools involved in genomic studies, including expression arrays, microRNA arrays, array CGH, ChIP-on-chip, methylation arrays, mutation analysis, genome-wide association studies, proteomic analysis, integrated functional genomic analysis and related bioinformatic and biostatistical analyses. Using human liver cancer as an example, we provide further information of how these genomic approaches can be applied in cancer research.
Chen
Xin
X
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, United States. xin.chen@ucsf.edu
Jorgenson
Eric
E
Cheung
Siu Tim
ST
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D035843:Biomedical Research / Q000379:methods; D016503:Drug Delivery Systems; D055808:Drug Discovery / Q000379:methods*; D023281:Genomics / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics; D035683:MicroRNAs / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D040901:Proteomics / Q000379:methods
D015415:Biomarkers; D035683:MicroRNAs