title: Local C-reactive protein expression in obliterative lesions and the bronchial wall in posttransplant obliterative bronchiolitis.
abstract: The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2-28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells (P < .0001) and fibroblasts (P = .02) resulted in occlusion of the bronchial lumens (P < .01). Influx of CD4+ (P < .001) and CD8+ (P < .0001) cells demonstrated allograft immune response. CRP positivity simultaneously increased in the bronchial walls (P < .01), in macrophages, myofibroblasts, and endothelial cells. Local CRP was predictive of features characteristic of OB (R = 0.456-0.879, P < .05-P < .0001). Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs (P < .05). During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.
authors.affiliation: Department of Cardiothoracic Surgery, Helsinki University Hospital, P.O. Box 340, 00029 Helsinki, Finland. outi.paivaniemi@uta.fi
authors.forename: Outi E
authors.initials: OE
authors.lastname: Päiväniemi
authors.forename: Paula K
authors.initials: PK
authors.lastname: Maasilta
authors.forename: Tiina L S
authors.initials: TL
authors.lastname: Vainikka
authors.forename: Hanni S
authors.initials: HS
authors.lastname: Alho
authors.forename: Pekka J
authors.initials: PJ
authors.lastname: Karhunen
authors.forename: Ulla-Stina
authors.initials: US
authors.lastname: Salminen
mesh_terms: D000818:Animals; D001980:Bronchi / Q000276:immunology* / Q000473:pathology / Q000637:transplantation*; D001989:Bronchiolitis Obliterans / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000276:immunology; D007150:Immunohistochemistry; D013552:Swine; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous / Q000009:adverse effects
chemical_list: D002097:C-Reactive Protein