title: A fundamental introduction to ion mobility mass spectrometry applied to the analysis of biomolecules.
abstract: Chemists are constantly striving for techniques that add dimensions of orthogonality with increased throughput and sample complexity. Ion mobility spectrometry (IM) is a gas-phase separation method that adds new dimensions to mass spectrometry (MS). IM separates gas-phase ions based on their collision cross-section and can be coupled with time-of-flight (TOF) mass spectrometry to yield a powerful tool used in the identification and characterization of proteins and peptides. A fundamental introduction to IM is presented with a focus on resolution, sensitivity, and orthogonality coupled with TOF-MS.
authors.affiliation: The Laboratory for Biological Mass Spectrometry, Texas A&M University, College Station, Texas, USA.
authors.forename: Guido F
authors.initials: GF
authors.lastname: Verbeck
authors.forename: Brandon T
authors.initials: BT
authors.lastname: Ruotolo
authors.forename: Holly A
authors.initials: HA
authors.lastname: Sawyer
authors.forename: Kent J
authors.initials: KJ
authors.lastname: Gillig
authors.forename: David H
authors.initials: DH
authors.lastname: Russell