title: Evidence for epistasis between SLC6A4 and a chromosome 4 gene as risk factors in major depression.
abstract: Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the SLC6A4 HTTLPR short allele revealed a linkage peak on chromosome 4 (maximum HLOD = 3.5). This evidence suggests epistasis between SLC6A4 and an unknown gene as risk factors for major depression.
authors.affiliation: Myriad Genetics, Salt Lake City, Utah, USA.
authors.forename: Chris D
authors.initials: CD
authors.lastname: Neff
authors.forename: Victor
authors.initials: V
authors.lastname: Abkevich
authors.forename: Jennifer
authors.initials: J
authors.lastname: Potter
authors.forename: Robin
authors.initials: R
authors.lastname: Riley
authors.forename: Donna
authors.initials: D
authors.lastname: Shattuck
authors.forename: David A
authors.initials: DA
authors.lastname: Katz
mesh_terms: D002894:Chromosomes, Human, Pair 4; D003865:Major Depressive Disorder / Q000235:genetics*; D004843:Epistasis, Genetic; D008040:Genetic Linkage; D006801:Humans; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins