Paclitaxel-induced interstitial pneumonia after drug-eluting stent implantation: report of a fatal case.
We report a case of paclitaxel-eluting stent implantation in an angina patient who developed interstitial pneumonia a few days afterward, and succumbed to fatal respiratory dysfunction despite corticosteroid therapy. Paclitaxel is an anti-neoplastic agent currently used as a coating substance for coronary stents to reduce the rate of restenosis. Pulmonary toxicity related to paclitaxel is not very common; however, this adverse event may on occasion be lethal. Although the efficacy and safety of drug-eluting stents for the treatment of ischemic heart disease is well established, physicians should keep in mind that paclitaxel-eluting stents have the potential to cause interstitial pneumonia.
Kato
Kimihiko
K
Department of Internal Medicine, Gifu Prefectural Tajimi Hospital, Tajimi.
Fukuda
Satoshi
S
Fujimaki
Tetsuo
T
Takano
Yuko
Y
Kunii
Eiji
E
Kato
Ken
K
Watanabe
Kazuko
K
Suzuki
Susumu
S
Yamada
Kiyoyasu
K
Yokoi
Kiyoshi
K
Mori
Toshiyuki
T
D000368:Aged; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D019919:Prosthesis Implantation / Q000009:adverse effects
D017239:Paclitaxel