Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older chinese people.
BACKGROUND
Inflammatory factors, adipocytokines, and the metabolic syndrome are important determinants of cardiometabolic disease. It remains unclear how physical activity is related to these risk factors. Our objective was to investigate single and joint associations of physical activity with inflammatory factors, adipocytokines, and the metabolic syndrome among middle-aged and older Chinese people.


RESULTS
A total of 3289 individuals (1458 men, 1831 women) 50 to 70 years of age participated in a population-based cross-sectional survey in Beijing and Shanghai, China. Levels of total physical activity were assessed with the International Physical Activity Questionnaire. High-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha receptor 2, adiponectin, and retinol-binding protein 4 were measured. The metabolic syndrome was defined using the updated National Cholesterol Education Program/Adult Treatment Panel III criteria for Asian Americans. Plasma concentrations of high-sensitivity C-reactive protein were 1.58, 1.74, and 1.27 mg/L (P=0.0138) and of adiponectin were 16.12, 16.20, and 17.21 mg/L (P=0.0078) among individuals with low, medium, and high levels of total physical activity, respectively, with adjustment for potential confounders. In the multivariable-adjusted logistic regression analyses, participants with higher levels of total physical activity had a lower risk of having the metabolic syndrome (odds ratio, 0.68; 95% confidence interval, 0.54 to 0.85; P for trend=0.001) compared with those with lower levels.


CONCLUSIONS
Being physically active is associated with a better profile of inflammatory factors and adipocytokines and a reduced risk of having the metabolic syndrome among Chinese people.
Yu
Zhijie
Z
Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Ye
Xingwang
X
Wang
Jing
J
Qi
Qibin
Q
Franco
Oscar H
OH
Rennie
Kirsten L
KL
Pan
An
A
Li
Huaixing
H
Liu
Yong
Y
Hu
Frank B
FB
Lin
Xu
X
D052242:Adiponectin / Q000097:blood; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000276:immunology / Q000378:metabolism; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000208:ethnology* / Q000276:immunology / Q000378:metabolism; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism; D012307:Risk Factors
C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; C101326:RBP4 protein, human; D047889:Receptors, Tumor Necrosis Factor, Type II; D054839:Retinol-Binding Proteins, Plasma; D002097:C-Reactive Protein