title: Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors.
abstract: Substituted benzimidazoles were profiled as inhibitors of kinesin spindle protein (KSP), an increasingly important target for the development of anticancer drugs. This series demonstrated the monoastral phenotypic response and was found to be active in both enzymatic and cellular-based assays.
authors.affiliation: Schering-Plough Research Institute, 320 Bent Street, Cambridge, MA 02141, USA. brian.lahue@spcorp.com
authors.forename: Brian R
authors.initials: BR
authors.lastname: Lahue
authors.forename: Yao
authors.initials: Y
authors.lastname: Ma
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Shipps
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Seghezzi
authors.forename: Ronald
authors.initials: R
authors.lastname: Herbst
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018938:Caco-2 Cells; D002460:Cell Line; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D016547:Kinesins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D001562:Benzimidazoles; D004791:Enzyme Inhibitors; C470243:KIF11 protein, human; D003577:Cytochrome P-450 Enzyme System; C031000:benzimidazole; D016547:Kinesins