title: Diffuse craniospinal metastases of intraventricular rhabdoid papillary meningioma with glial fibrillary acidic protein expression: a case report.
abstract: Rhabdoid papillary meningioma is a recently described clinically aggressive variant of meningiomas with a high recurrence rate. Additionally, only one case of intraventricular rhabdoid meningioma has been reported so far. We present a case of a 50-year-old man who developed an intracranial tumor of the left lateral ventricle at the trigone, for which he underwent total tumor resection followed by gamma knife radiosurgery for recurrence of the tumor. The histological diagnosis was rhabdoid papillary meningioma. Five years after surgery, diffuse craniospinal leptomeningeal metastases developed and subtotal removal of the spinal tumor was performed. The spinal tumor was considered to have metastasized via cerebrospinal fluid (CSF) in view of its histological features that were identical to those of the primary tumor. Immunohistochemistry revealed the unusual cytoplasmic expression of glial fibrillary acidic protein (GFAP) of tumor cells. To our knowledge, this is the first reported case of diffuse craniospinal metastases of intraventricular rhabdoid papillary meningioma with GFAP expression and the second reported case of the rhabdoid subtype amongst intraventricular meningiomas.
authors.affiliation: Department of Neurosurgery, Wonkwang University School of Medicine, Iksan 570-749, Republic of Korea.
authors.forename: Ki Seong
authors.initials: KS
authors.lastname: Eom
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Kim
authors.forename: Tae Young
authors.initials: TY
authors.lastname: Kim
mesh_terms: D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary*; D002291:Carcinoma, Papillary / Q000473:pathology*; D002551:Cerebral Ventricle Neoplasms / Q000473:pathology*; D017809:Fatal Outcome; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis* / Q000235:genetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008579:Meningioma / Q000473:pathology*; D008875:Middle Aged; D019635:Neurosurgical Procedures; D018335:Rhabdoid Tumor / Q000473:pathology*; D013125:Spinal Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary*; D014057:Tomography, X-Ray Computed
chemical_list: D005904:Glial Fibrillary Acidic Protein