Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities.
Two new neo-clerodane diterpenoid alkaloids, scutebarbatine O (1) and 6-O-nicotinoylscutebarbatine G (2), were isolated from the whole plant of Scutellaria barbata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1 and 2 showed cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 2.1-5.7 microM.
Dai
Sheng-Jun
SJ
School of Pharmaceutical Science, Yantai University, Yantai, China. daishengjun_9@hotmail.com
Peng
Wei-Bing
WB
Shen
Li
L
Zhang
De-Wu
DW
Ren
Yan
Y
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D031363:Scutellaria / Q000737:chemistry*
C541315:6-O-nicotinoylscutebarbatine G; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal; C541314:scutebarbatine O