Two cases of discontinuation syndrome following cessation of memantine.
Although memantine is widely used and generally considered safe, an abrupt cessation of memantine may result in discontinuation syndrome that can be distressing and result in decline of natural course. We report two patients who developed significant behavior disturbance after abrupt cessation of memantine. Although re-trial of memantine improves these symptoms, more additional drugs may be required to achieve previous status. Therefore, abrupt cessation of memantine should be prudent and require cautious follow up.
Kwak
Yong Tae
YT
Department of Neurology, Yong-in Hyoja Geriatric Hospital, Yongin, Korea. ytkwak@drkwak.com
Han
Il-Woo
IW
Suk
Seung-Han
SH
Koo
Min-Seong
MS
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008559:Memantine / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*; D013577:Syndrome; D016896:Treatment Outcome
D008559:Memantine