Dynamic regulation of RNA editing of ion channels and receptors in the mammalian nervous system.
The post-transcriptional modification of mammalian transcripts in the central nervous system by adenosine-to-inosine RNA editing is an important mechanism for the generation of molecular diversity, and serves to regulate protein function through recoding of genomic information. As the molecular players and an increasing number of edited targets are identified and characterized, adenosine-to-inosine modification serves as an exquisite mechanism for customizing channel function within diverse biological niches. Here, we review the mechanisms that could regulate adenosine-to-inosine RNA editing and the impact of dysregulation in clinical conditions.
Tan
Bao Zhen
BZ
Department of Physiology, Yong Loo Lin School Medicine, National University of Singapore, 117597, Singapore. g0601821@nus.edu.sg
Huang
Hua
H
Lam
Runyi
R
Soong
Tuck Wah
TW
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007473:Ion Channels / Q000235:genetics* / Q000378:metabolism; D008322:Mammals / Q000235:genetics*; D009420:Nervous System / Q000378:metabolism*; D017393:RNA Editing / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism
D007473:Ion Channels; D011956:Receptors, Cell Surface