Angiosarcoma of the retroperitoneum: report on a patient treated with sunitinib.
A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases. After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly. Because few chemotherapeutic options were available for her, sunitinib (37.5 mg/day, daily) as a salvage regimen was administered. Although sunitinib was interrupted after two weeks due to hematologic abnormalities, some metastatic nodules were regressed. Therefore, sunitinib was recommenced at a reduced dose (25 mg/day, daily). Serial computed tomography scans showed variable response in each tumor, however, sunitinib at least delayed tumor progression, compared to previous chemotherapy. With this case report, we suggest sunitinib may be effective against angiosarcomas. When sunitinib is administered to patients with angiosarcomas, hematologic abnormalities should be monitored frequently as severe hematologic toxicity may be caused either by sunitinib per se or angiosarcoma.
Yoo
Changhoon
C
Department of Internal medicine, Asan Medical Center, University of Ulsan, College of Medicine, 388-1 Pungnap2-dong, Songpa-gu, Seoul 138-736, South Korea.
Kim
Jeong-Eun
JE
Yoon
Shin-Kyo
SK
Kim
Song Cheol
SC
Ahn
Jin-Hee
JH
Kim
Tae Won
TW
Suh
Cheolwon
C
Lee
Jae-Lyun
JL