Ameliorative effects of Vaccaria segetalis extract on osteopenia in ovariectomized rats.
The purpose of this study was to determine the ameliorative effects of a crude extract of Vaccaria segetalis (Neck.) Garcke (Caryophyllaceae) (VSE) on osteopenia in ovariectomized (OVX) rats over 12 weeks. Rats were divided into the sham and OVX groups. The OVX rats were allowed to lose bone for 6 weeks. At 6 weeks post-OVX, the OVX rats were divided into four groups treated with water, 17beta-estradiol (30 microg/kg, daily subcutaneous injection), or VSE (0.5 or 1.0 g/kg, daily, orally) for 6 weeks. In OVX rats, the increases of serum total cholesterol were significantly decreased by VSE or 17beta-estradiol treatment. There were decreases in bone density and calcium content, including the left femur and the fourth lumbar vertebra, when compared with the sham control rats. Treatment with 17beta-estradiol or VSE ameliorated these changes induced by OVX. In addition, ovariectomy increased urinary deoxypyridinoline (DPD) amounts (P < 0.001). The increases were suppressed by 17beta-estradiol and 0.5 or 1.0 g/kg VSE (P < 0.01, P < 0.05, P < 0.01, respectively). Our results demonstrated that VSE ameliorates ovariectomy-induced osteopenia by inhibition of bone resorption.
Shih
Chun-Ching
CC
Institute of Pharmaceutical Science and Technology, College of Health Science, Central Taiwan University of Science and Technology, 11, Po-Tze Lane, Takun, Taichung, Taiwan, ROC. ccshih@ctust.edu.tw
Lin
Cheng-Hsiu
CH
Lin
Wei-Li
WL
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects*; D001851:Bone Diseases, Metabolic / Q000188:drug therapy; D001862:Bone Resorption / Q000517:prevention & control; D002118:Calcium / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D015394:Molecular Structure; D010052:Ovariectomy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D031245:Vaccaria / Q000737:chemistry*
D010936:Plant Extracts; D004958:Estradiol; D002784:Cholesterol; D000469:Alkaline Phosphatase; D002118:Calcium