title: Prostatic aspergillosis in a heart transplant recipient: case report and review.
abstract: In this study we report the first case of invasive prostatic aspergillosis (IPRA) in a heart recipient with post-transplantation antibody deficiency, and review the other 11 cases described in the medical literature. Seven patients were immunocompromised and 6 had dissemination to other sites. Examination of the prostate usually revealed enlargement, with or without nodular lesions. Transrectal ultrasonography or computed tomography scan can provide the diagnosis, although this should be confirmed with biopsy and culture of the lesion. Urine culture can be negative and treatment should include long-term systemic anti-fungal therapy and, in most cases, prostatectomy.
authors.affiliation: Department of Clinical Microbiology-Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Maricela
authors.initials: M
authors.lastname: Valerio
authors.forename: Ana
authors.initials: A
authors.lastname: Fernandez-Cruz
authors.forename: Juan
authors.initials: J
authors.lastname: Fernández-Yañez
authors.forename: Jesús
authors.initials: J
authors.lastname: Palomo
authors.forename: Jesús
authors.initials: J
authors.lastname: Guinea
authors.forename: Ramón
authors.initials: R
authors.lastname: Durán
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Sarmiento
authors.forename: Javier
authors.initials: J
authors.lastname: Carbone
authors.forename: Emilio
authors.initials: E
authors.lastname: Bouza
authors.forename: Patricia
authors.initials: P
authors.lastname: Muñoz
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy; D001706:Biopsy; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D011467:Prostate / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D011468:Prostatectomy; D011469:Prostatic Diseases / Q000175:diagnosis* / Q000382:microbiology* / Q000628:therapy; D014463:Ultrasonography
chemical_list: D000935:Antifungal Agents