Successful treatment with rituximab in an elderly patient with acquired factor VIII inhibitor.
We report here on an elderly patient, aged 88 years, who developed acquired hemophilia, with a high titer of factor VIII inhibitors and severe hemorrhage, in the absence of a detectable cause. Marked and prolonged efficacy was observed after rituximab.
Cretel
Elodie
E
Department of Geriatrics, Sainte-Marguerite Hospital, Marseille, France. elodie.cretel@ap-hm.fr
Jean
Rodolphe
R
Chiche
Laurent
L
Durand
Jean Marc
JM
D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D003029:Coagulants / Q000276:immunology / Q000627:therapeutic use; D005169:Factor VIII / Q000276:immunology / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D000069283:Rituximab; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D003029:Coagulants; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D000069283:Rituximab; D005169:Factor VIII