title: Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases.
abstract: The anticholinesterase activities of newly synthesized phosphorothioates and phosphorodithioates were investigated. The compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition potency through IC(50) determination. The selectivities of the synthesized compounds toward both enzymes were determined and compared in terms of their molecular structures.
authors.affiliation: Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan, Iran. kaboudin@iasbs.ac.ir
authors.forename: Babak
authors.initials: B
authors.lastname: Kaboudin
authors.forename: Saeed
authors.initials: S
authors.lastname: Emadi
authors.forename: Atefeh
authors.initials: A
authors.lastname: Hadizadeh
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D002091:Butyrylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology; D009946:Organothiophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010710:Phosphates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009946:Organothiophosphorus Compounds; D010710:Phosphates; C083120:phosphorodithioic acid; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase