title: A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial.
abstract: Tardive dyskinesia (TD) is a movement disorder characterized by involuntary oro-facial, limb, and truncal movements. As a genetic basis for inter-individual variation is assumed, there have been a sizeable number of candidate gene studies. All subjects met diagnostic criteria for schizophrenia and were randomized to receive antipsychotic medications as participants in the Clinical Antipsychotic Trials of Intervention Effectiveness project (CATIE). TD was assessed via the Abnormal Involuntary Movement Scale at regular intervals. Probable TD was defined as meeting Schooler-Kane criteria at any scheduled CATIE visit (207/710 subjects, 29.2%). A total of 128 candidate genes were studied in 710 subjects-2,580 SNPs in 118 candidate genes selected from the literature (e.g., dopamine, serotonin, glutamate, and GABA pathways) and composite genotypes for 10 drug-metabolizing enzymes. No single marker or haplotype association reached statistical significance after adjustment for multiple comparisons. Thus, we found no support for either novel or prior associations from the literature.
authors.affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Huei-Ting
authors.initials: HT
authors.lastname: Tsai
authors.forename: Stanley N
authors.initials: SN
authors.lastname: Caroff
authors.forename: Del D
authors.initials: DD
authors.lastname: Miller
authors.forename: Joseph
authors.initials: J
authors.lastname: McEvoy
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Lieberman
authors.forename: Kari E
authors.initials: KE
authors.lastname: North
authors.forename: T Scott
authors.initials: TS
authors.lastname: Stroup
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Sullivan
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000235:genetics*; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics
chemical_list: D014150:Antipsychotic Agents