title: Psychiatrists' use, knowledge and attitudes to first- and second-generation antipsychotic long-acting injections: comparisons over 5 years.
abstract: Psychiatrists' attitudes and knowledge about antipsychotic long-acting injections (LAIs) are important given the increasing emphasis on patient choice in treatment and the availability of second-generation antipsychotic (SGA) LAIs. A cross-sectional study of consultant psychiatrists' attitudes and knowledge in North West England was carried out. A pre-existing questionnaire on clinicians' attitudes and knowledge regarding LAIs was updated. Of 102 participants, 50% reported a decrease in their use of LAIs. LAI prescribing was evenly split between first-generation antipsychotic (FGA) and SGA-LAIs. Most regarded LAIs as associated with better adherence (89%) than tablets. A substantial proportion believed that LAIs could not be used in first-episode psychosis (38%) and that patients always preferred tablets (33%). Compared with a previous sample, the current participants scored more favourably on a patient-centred attitude subscale (60.4% vs 63.5%, P = 0.034) and significantly fewer regarded LAIs as being stigmatising and old-fashioned. Reported LAI prescribing rates have decreased in the last 5 years despite an SGA-LAI becoming available and most clinicians regarding LAIs as effective. Most attitudes and knowledge have remained stable although concerns about stigma with LAI use have decreased. Concerns about patient acceptance continue as do negative views about some aspects of LAI use; these may compromise medication choices offered to patients.
authors.affiliation: Division of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK. m.patel@iop.kcl.ac.uk
authors.forename: M X
authors.initials: MX
authors.lastname: Patel
authors.forename: P M
authors.initials: PM
authors.lastname: Haddad
authors.forename: I B
authors.initials: IB
authors.lastname: Chaudhry
authors.forename: S
authors.initials: S
authors.lastname: McLoughlin
authors.forename: N
authors.initials: N
authors.lastname: Husain
authors.forename: A S
authors.initials: AS
authors.lastname: David
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D003692:Delayed-Action Preparations; D004739:England; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007267:Injections; D008297:Male; D055118:Medication Adherence / Q000523:psychology; D008875:Middle Aged; D057240:Patient Preference / Q000523:psychology; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data* / Q000639:trends*; D057285:Precision Medicine / Q000523:psychology / Q000639:trends; D011570:Psychiatry; D012559:Schizophrenia / Q000188:drug therapy; D011795:Surveys and Questionnaires
chemical_list: D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations