title: Anti-inflammatory and anticancer activity of ergoflavin isolated from an endophytic fungus.
abstract: Biodiversity is a major resource for identification of new molecules with specific therapeutic activities. To identify such an active resource, high throughput screening (HTS) of the extracts prepared from such diversity are examined on specific functional assays. Based on such HTS studies and bioactivity-based fractionation, we have isolated ergoflavin, a pigment from an endophytic fungus, growing on the leaves of an Indian medicinal plant Mimosops elengi (bakul). We report here the isolation, structure elucidation, and biological properties of this compound, which showed good anti-inflammatory and anticancer activities.
authors.affiliation: Piramal Life Sciences Limited, 1 Nirlon Complex, Off Western Express Highway, Near NSE Complex, Goregaon (East), Mumbai, India. sunil.deshmukh@piramal.com
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Deshmukh
authors.forename: Prabhu Dutt
authors.initials: PD
authors.lastname: Mishra
authors.forename: Asha
authors.initials: A
authors.lastname: Kulkarni-Almeida
authors.forename: Shilpa
authors.initials: S
authors.lastname: Verekar
authors.forename: Manas Ranjan
authors.initials: MR
authors.lastname: Sahoo
authors.forename: Giridharan
authors.initials: G
authors.lastname: Periyasamy
authors.forename: Hitesh
authors.initials: H
authors.lastname: Goswami
authors.forename: Amit
authors.initials: A
authors.lastname: Khanna
authors.forename: Arun
authors.initials: A
authors.lastname: Balakrishnan
authors.forename: Ram
authors.initials: R
authors.lastname: Vishwakarma
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032130:Mimusops / Q000382:microbiology; D018515:Plant Leaves / Q000382:microbiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D002867:Chromones; D015850:Interleukin-6; D007783:Lactones; D014409:Tumor Necrosis Factor-alpha; C542671:ergoflavin