title: Dynamic kinetic asymmetric transfer hydrogenation of racemic 2,4-diaryl-2,3-dihydrobenzo[b][1,4]diazepines catalyzed by chiral phosphoric acids.
abstract: Dynamic kinetic Transfer hydrogenation reaction of 2-methyl-2,4-diaryl-2,3-dihydrobenzo[b][1,4]diazepines, using phosphoric acids as catalysts and Hantzsch ester as hydride source, has been studied. A 3,3'-H8-binol derived phosphoric acid has been identified the optimal chiral catalyst for this transformation, affording 1,3-diamine derivatives with up to 8/1 dr, 86% ee and 94% ee for the major and minor diastereomers, respectively.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Han
authors.forename: Han
authors.initials: H
authors.lastname: Xiao
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong
mesh_terms: D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003959:Diamines / Q000737:chemistry; D006865:Hydrogenation; D007697:Kinesics; D008968:Molecular Conformation; D010756:Phosphoric Acids / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001381:Azepines; D003959:Diamines; D010756:Phosphoric Acids