title: Three-dimensional spring model: a new hypothesis of pathogenesis of adolescent idiopathic scoliosis.
abstract: The pathogenesis of adolescent idiopathic scoliosis (AIS) has been the subject of many studies, but remains little understood. Previous work has shown that there is a correlation between the uncoupled spinal neuro-osseous growth and AIS. We believe that this uncoupled spinal neuro-osseous growth may also contribute to formation of normal curvature of the spine in the sagittal plane during the childhood. We speculate a three-dimensional spring model to better understand our hypothesis. The normal curvature of the spine, the uncoupled spinal neuro-osseous growth, and the overgrowth of the spine in the puberty may be the crucial factors in the pathogenesis of AIS.
authors.affiliation: Scoliosis Research Center, Orthopedic Department, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Zongde
authors.initials: Z
authors.lastname: Yang
authors.forename: Yang
authors.initials: Y
authors.lastname: Xie
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000293:Adolescent; D006801:Humans; D008962:Models, Theoretical; D011859:Radiography; D012600:Scoliosis / Q000000981:diagnostic imaging / Q000209:etiology*