title: Neopterin and C-reactive protein in the course of Stevens-Johnson syndrome: report of a case.
abstract: We describe a patient originally suffering from a depressive syndrome who developed Stevens-Johnson syndrome after 12 days of treatment with lamotrigine. The clinical symptoms and the inflammation parameters neopterin and C-reactive protein were documented. Neopterin values showed a good correlation with the course of the disease, which, to the best of our knowledge, has not been reported previously. C-reactive protein followed the neopterin curve with a delay of 4 days. Since neopterin is a widely available parameter it should be considered as a routine measurement in this type of hyperergic reaction. It might help to identify the beginning, the maximum and the regression of the disease in order to support therapeutic decisions.
authors.affiliation: Department of Anaesthesiology/Department of Palliative Medicine, RWTH Aachen University, Pauwelsstrasse 30, USA. lbertram@ukaachen.de
authors.forename: Linda
authors.initials: L
authors.lastname: Bertram
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Liss
authors.forename: Michael
authors.initials: M
authors.lastname: Grözinger
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000627:therapeutic use; D001706:Biopsy; D002097:C-Reactive Protein / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008803:Mianserin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D008875:Middle Aged; D000078785:Mirtazapine; D019798:Neopterin / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D020280:Sertraline / Q000009:adverse effects / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000097:blood* / Q000139:chemically induced* / Q000473:pathology; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D000929:Antidepressive Agents, Tricyclic; D002097:C-Reactive Protein; D000077213:Lamotrigine; D008803:Mianserin; D000078785:Mirtazapine; D019798:Neopterin; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline; D014227:Triazines