The first total synthesis of (+/-)-apparicine.
The first total synthesis of the indole alkaloid apparicine has been developed through a sequence that includes an indole-templated ring-closing metathesis and a vinyl halide Heck cyclization.
Bennasar
M-Lluïsa
ML
Laboratory of Organic Chemistry, Faculty of Pharmacy and Institut de Biomedicina (IBUB), University of Barcelona, Barcelona 08028, Spain. bennasar@ub.edu
Zulaica
Ester
E
Solé
Daniel
D
Alonso
Sandra
S
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007211:Indoles / Q000737:chemistry; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry
D000470:Alkaloids; D007211:Indoles; D014753:Vinyl Compounds; C008811:pericalline; C030374:indole