title: A surgical reentry study on the influence of platelet-rich plasma in enhancing the regenerative effects of bovine porous bone mineral and guided tissue regeneration in the treatment of intrabony defects in humans.
abstract: BACKGROUND
  The purpose of this study was to evaluate the additional benefits provided by the incorporation of platelet-rich plasma (PRP) into a regenerative protocol consisting of bovine porous bone mineral (BPBM) and guided tissue regeneration (GTR) in the treatment of intrabony defects in humans.
  
  
  METHODS
  Twenty-three paired intrabony defects were surgically treated using a split-mouth design. Defects were treated with BPBM/GTR/PRP (experimental group) or with BPBM/GTR (control group). The clinical parameters evaluated included changes in probing depth, clinical attachment level, and defect fill as revealed by reentry surgeries at 6 months.
  
  
  RESULTS
  Preoperative probing depths, attachment levels, and transoperative bone measurements were similar for the two groups. Post-surgical measurements taken at 6 months revealed that both treatment modalities resulted in a significant decrease in probing depth, gain in clinical attachment, and bone fill of the defects compared to baseline. Postoperative differences observed between the two groups were 0.72 +/- 0.36 mm at buccal sites and 0.90 +/- 0.32 mm at lingual sites for probing depth, 0.82 +/- 0.41 mm at buccal sites and 0.78 +/- 0.38 at lingual sites for gain in clinical attachment, and 0.85 +/- 0.36 mm at buccal sites and 0.94 +/- 0.42 mm at lingual sites for defect fill, all favoring the experimental sites. However, none of the differences were statistically significant.
  
  
  CONCLUSIONS
  Within the limitations related to using a small sample size, PRP did not significantly augment the effects of BPBM and GTR in promoting the clinical resolution of intrabony defects.
authors.affiliation: Division of Associated Clinical Specialties, Section of Periodontics, University of California, Los Angeles School of Dentistry, Los Angeles, CA, USA. pcamargo@dentistry.ucla.edu
authors.forename: Paulo M
authors.initials: PM
authors.lastname: Camargo
authors.forename: Vojislav
authors.initials: V
authors.lastname: Lekovic
authors.forename: Michael
authors.initials: M
authors.lastname: Weinlaender
authors.forename: Tihana
authors.initials: T
authors.lastname: Divnic-Resnik
authors.forename: Marija
authors.initials: M
authors.lastname: Pavlovic
authors.forename: E Barrie
authors.initials: EB
authors.lastname: Kenney
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D053657:Platelet-Rich Plasma; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen