Individual cell-based models of cell scatter of ARO and MLP-29 cells in response to hepatocyte growth factor.
The different behaviors of colonies of two cell lines, ARO (thyroid carcinoma-derived cells) and MLP-29 (mouse liver progenitor cells), in response to hepatocyte growth factor (HGF) are described deducing suitable cellular Potts models (CPM). It is shown how increased motility and decreased adhesiveness are responsible for cell-cell dissociation and tissue invasion in the ARO cells. On the other hand, it is shown that, in addition to the biological mechanisms above, it is necessary to include directional persistence in cell motility and HGF diffusion to describe the scattering and the branching processes characteristic of MLP-29 cells.
Scianna
Marco
M
Department of Mathematics, Politecnico di Torino, Italy.
Merks
Roeland M H
RM
Preziosi
Luigi
L
Medico
Enzo
E
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008858:Microscopy, Phase-Contrast; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D013234:Stem Cells / Q000187:drug effects; D013964:Thyroid Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured
D017228:Hepatocyte Growth Factor