title: BK virus nephropathy in an immunodeficient patient with chronic lymphocytic leukemia.
abstract: BACKGROUND
  BK virus, genus polyomavirus, is known as an important cause of nephropathy (BKVN) in renal transplant patients. Cases of BKVN in native kidneys are rare.
  
  
  OBJECTIVE
  To report a case of BKVN in a patient with chronic lymphocytic leukemia (CLL) and to examine viral and immune parameters.
  
  
  METHODS
  Quantitative BK virus DNA in plasma and relevant immune parameters were recorded in one CLL patient with BKVN and ten consecutive CLL patients without BKVN.
  
  
  RESULTS
  BKVN in the native kidneys of a CLL patient was histologically confirmed. The presence of BKVN correlated with immunologic parameters as well as factors known to cause renal tissue injury. BK viral load levels in the patient steadily increased and exceeded those of the control CLL patients.
  
  
  CONCLUSIONS
  The results document a pathogenic role for BK virus in native kidneys of immuno-compromised CLL patients and indicate a role for quantitative BK virus DNA detection for early management of BKVN in native kidneys.
authors.affiliation: Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Akke
authors.initials: A
authors.lastname: van der Bij
authors.forename: Michiel
authors.initials: M
authors.lastname: Betjes
authors.forename: Jan
authors.initials: J
authors.lastname: Weening
authors.forename: Jan
authors.initials: J
authors.lastname: Cornelissen
authors.forename: Ted
authors.initials: T
authors.lastname: Mes
authors.forename: Albertus
authors.initials: A
authors.lastname: Osterhaus
authors.forename: Matthias
authors.initials: M
authors.lastname: Beersma
mesh_terms: D001739:BK Virus / Q000302:isolation & purification*; D004279:DNA, Viral / Q000097:blood; D006801:Humans; D016867:Immunocompromised Host; D007674:Kidney Diseases / Q000473:pathology / Q000821:virology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000175:diagnosis* / Q000821:virology; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000821:virology
chemical_list: D004279:DNA, Viral