title: [Application of individually designed trans-fissure approach in brain surgery: analysis of 90 cases].
abstract: OBJECTIVE
  To explore the feasibility and value of trans-fissure approaches in brain surgery through individually designed craniotomy.
  
  
  METHODS
  Ninety patients with intracranial space-occupying lesions, 47 males and 58 females, aged (43 +/- 14) (1 - 68), were treated by individualized trans-fissure approach surgeries. Linear scalp incision or "horseshoe shape" scalp incision were designed to perform the operation, with a bone flap 3 - 4 cm in diameter. The shortest approach to reach the lesion was decided under the guidance of neuro-navigation and real-time B-mode ultrasonography. Then the lesions were removed through natural cortical fissures. Another 79 patients with intracranial space-occupying lesions, 53 males and 51 females, aged (42 +/- 11) (15 -73), undergoing classical surgeries in the same period were used as control group. The average operation time, size of bone flap, amount of blood loss, hospitalization time, and hospitalization cost were compared between these 2 groups.
  
  
  RESULTS
  The operation time of the individually designed trans-fissure approach group was (3.1 +/- 1.6) hours (1.33 - 10.83 hours), significantly shorter than that of the control group [(4.8 +/- 1.9) hrs, P < 0.05]. The amount of blood loss of the individually designed trans-fissure approach group was (173 +/- 168) ml (20 m - 500 ml), significantly less than that of the control group [(410 +/- 61) ml, P < 0.01]. The size of bone flap of the individually designed trans-fissure approach group was (12 +/- 5) cm2 [(1 - 25) cm2], significantly smaller than that of the control group [(20. +/- 9) cm2, P < 0.01]. Four of the 90 patients of the individually designed trans-fissure approach group received retransfusion, compared to 15 in the control group, during operation. No infection or other significant complications occurred after operation in the individually designed trans-fissure approach group. The hospitalization time of the individually designed trans-fissure approach group was (20 +/- 6) days (9 - 39 days), significantly shorter than that of the control group [(24 +/- 7) days, P < 0.01]. The average hospitalization cost of the individually designed trans-fissure approach group was (23171 +/- 7280) yuan RMB; significantly lower than that of the control group [(28096 +/- 10822) yuan, P < 0.01].
  
  
  CONCLUSIONS
  One of the land markers of minimally invasive neurosurgery, individualized trans-fissure approach has been proved to be an effective minimally invasive approach that leads to better outcome and fewer complications after operation.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China.
authors.forename: Ji-Zong
authors.initials: JZ
authors.lastname: Zhao
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Mao-Zhi
authors.initials: MZ
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Ya-Juan
authors.initials: YJ
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003399:Craniotomy / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D055815:Young Adult