Identification of a novel HLA-DRB1 allele, HLA-DRB1*1217, in a Korean individual.
We report a new DRB1 allele, DRB1*1217, identified by direct sequencing of a bacterial artificial chromosome (BAC) clone originated from genomic DNA of a Korean donor. DRB1*1217 differs from previously reported DRB1*120201 by a single nucleotide substitution, which results in an amino acid change at codon 67 [TTC-->ATC (F>I)].
Park
M H
MH
Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Seoul, Korea.
Kim
Y
Y
Lee
J Y
JY
D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D005091:Exons / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007723:Korea; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains