title: Reduction in QSART and vasoactive intestinal polypeptide expression in the skin of Parkinson's disease patients and its relation to dyshidrosis.
abstract: BACKGROUND
  With regards to dyshidrosis in Parkinson's disease (PD), there is no established and consistent view on the occurrence sites, frequency and etiology, although there have been several reports on hypohidrosis of the limbs and sudoresis on the face/cervical region.
  
  
  METHODS
  Hydrosis in the forearms of PD patients and healthy individuals were compared by quantitative sudomotor axon reflex test (QSART). The expression of various neuropeptides and alpha-synuclein was examined with immunohistochemical staining.
  
  
  RESULTS
  There was a significant reduction in QSART of PD patients but not of healthy controls. Reduced expression of vasoactive intestinal polypeptide (VIP) was also detected in the sweat glands of PD patients.
  
  
  CONCLUSIONS
  Reduction in QSART and VIP expression in the sweat glands might be involved in the dyshidrosis of PD patients.
authors.affiliation: Department of Dermatology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.
authors.forename: Morihiro
authors.initials: M
authors.lastname: Kawada
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tamada
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Simizu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yanagishita
authors.forename: Noriko
authors.initials: N
authors.lastname: Yamashita
authors.forename: Natsuko
authors.initials: N
authors.lastname: Ishida
authors.forename: Daisuke
authors.initials: D
authors.lastname: Watanabe
authors.forename: Mari
authors.initials: M
authors.lastname: Yoshida
authors.forename: Tatsu
authors.initials: T
authors.lastname: Ibi
authors.forename: Kou
authors.initials: K
authors.lastname: Sahashi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hashizume
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Matsumoto
mesh_terms: D000368:Aged; D001369:Axons / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010300:Parkinson Disease / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D012018:Reflex / Q000502:physiology*; D012867:Skin / Q000378:metabolism / Q000503:physiopathology*; D013543:Sweat Gland Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D013545:Sweat Glands / Q000294:innervation / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000096:biosynthesis*; D051844:alpha-Synuclein / Q000096:biosynthesis
chemical_list: D051844:alpha-Synuclein; D014660:Vasoactive Intestinal Peptide