title: Metabolic syndrome is independently associated with microalbuminuria in type 2 diabetes.
abstract: We opted in this study to evaluate the association between metabolic syndrome (MetS) and microalbuminuria in type 2 diabetes. A total of 800 adults (344 males; age 54.8 +/- 9.6 years) with type 2 diabetes were studied. MetS was defined by the International Diabetes Federation criteria and microalbuminuria by urinary albumin excretion between 30 and 299 mg/day on at least two of three occasions. Patients with macroalbuminuria and those with poor renal function were not included. Microalbuminuria was present in 237 (29.6%) patients with MetS and increased in prevalence with increasing numbers of metabolic abnormalities (P < 0.001). The normo- and micro-albuminuric groups were not significantly different in age, sex, and renal function. However, MetS was significantly more common among patients with (90.3%) than those without (76.6%) microalbuminuria (P < 0.01). In multivariate regression, MetS was the strongest correlate of microalbuminuria (OR = 3.31, 95% CI = 1.91-5.75; P < 0.01). In conclusion, MetS is independently associated with microalbuminuria in type 2 diabetes.
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran. esteghamati@tums.ac.ir
authors.forename: Alireza
authors.initials: A
authors.lastname: Esteghamati
authors.forename: Armin
authors.initials: A
authors.lastname: Rashidi
authors.forename: Omid
authors.initials: O
authors.lastname: Khalilzadeh
authors.forename: Omid
authors.initials: O
authors.lastname: Khalilzedeh
authors.forename: Haleh
authors.initials: H
authors.lastname: Ashraf
authors.forename: Mehrshad
authors.initials: M
authors.lastname: Abbasi
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000453:epidemiology* / Q000503:physiopathology; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D008875:Middle Aged; D018579:Patient Selection; D015995:Prevalence; D055105:Waist Circumference
chemical_list: D007004:Hypoglycemic Agents