Systemic oxidative stress associated with the neurological diseases of aging.
Markers of oxidative stress were measured in blood samples of 338 subjects (965 observations): Alzheimer's, vascular dementia, diabetes (type II) superimposed to dementias, Parkinson's disease and controls. Patients showed increased thiobarbituric acid reactive substances (+21%; P < 0.05), copper-zinc superoxide dismutase (+64%; P < 0.001) and decreased antioxidant capacity (-28%; P < 0.001); pairs of variables resulted linearly related across groups (P < 0.001). Catalase and glutathione peroxidase, involved in discrimination between diseases, resulted non-significant. When diabetes is superimposed with dementias, changes resulted less marked but significant. Also, superoxide dismutase resulted not linearly correlated with any other variable or age-related (pure Alzheimer's peaks at 70 years, P < 0.001). Systemic oxidative stress was significantly associated (P << 0.001) with all diseases indicating a disbalance in peripheral/adaptive responses to oxidative disorders through different free radical metabolic pathways. While other changes - methionine cycle, insulin correlation - are also associated with dementias, the responses presented here show a simple linear relation between prooxidants and antioxidant defenses.
Serra
Jorge A
JA
Free Radicals Program, Programa de Radicales Libres, Consejo Nacional de Investigaciones Científicas y Técnicas, Oxidative Stress Laboratory, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Junín 954, C1113AAD Buenos Aires, Argentina. jserra@ffyb.uba.ar
Domínguez
Raúl O
RO
Marschoff
Enrique R
ER
Guareschi
Eduardo M
EM
Famulari
Arturo L
AL
Boveris
Alberto
A
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism; D015140:Dementia, Vascular / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D000975:Antioxidants; D005609:Free Radicals; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase