Influenza-associated central nervous system dysfunction in Taiwanese children: clinical characteristics and outcomes with and without administration of oseltamivir.
Seventy-four of the 2651 patients (2.8%) with influenza aged <18 years had signs or symptoms of central nervous system dysfunction presenting to the hospital. None had oseltamivir exposure before the onset of central nervous system dysfunction. Seventeen children received oseltamivir therapy after admission and no significant difference between administration of oseltamivir and outcome was observed (P = 0.1512 by Fisher exact test).
Huang
Yhu-Chering
YC
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Kweishan, Taoyan, Taiwan. ychuang@adm.cgmh.org.tw
Li
Wen-Chen
WC
Tsao
Kuo-Chien
KC
Huang
Chung-Guei
CG
Chiu
Cheng-Hsun
CH
Lin
Tzou-Yien
TY
D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000473:pathology* / Q000503:physiopathology / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D053139:Oseltamivir / Q000627:therapeutic use*; D013624:Taiwan; D016896:Treatment Outcome
D000998:Antiviral Agents; D053139:Oseltamivir