title: Value of history-taking in syncope patients: in whom to suspect long QT syndrome?
abstract: OBJECTIVE
  Long QT syndrome (LQTS), a potentially fatal disorder, has to be distinguished from non-fatal conditions. Our aim was to investigate whether history-taking can be used in identifying patients likely to have LQTS.
  
  
  RESULTS
  We compared the characteristics of a group of LQTS patients with syncope patients presenting at the emergency department (ED) and vasovagal patients younger than 40 years of age. Thirty-two LQTS patients were included. We included 113 patients at the ED and 69 vasovagal patients. Family history of syncope, sudden cardiac death, or cardiovascular disease was found more often in LQTS patients. Palpitations were the only symptom reported more often in this group. Syncope while supine, during emotional stress and associated with exercise was also more common among LQTS. Standing as a trigger was found more often in ED and vasovagal patients.
  
  
  CONCLUSIONS
  We conclude that a family history for syncope and sudden cardiac death, palpitations as a symptom, supine syncope, syncope associated with exercise, and emotional stress place patients at higher risk for LQTS. These findings should alert physicians to the potentially life-threatening illness of LQTS, and act accordingly by obtaining an electrocardiogram and paying specific attention to the QT interval.
authors.affiliation: Department of Cardiology B2, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.
authors.forename: Nancy
authors.initials: N
authors.lastname: Colman
authors.forename: Annemieke
authors.initials: A
authors.lastname: Bakker
authors.forename: Mark
authors.initials: M
authors.lastname: Linzer
authors.forename: Johannes B
authors.initials: JB
authors.lastname: Reitsma
authors.forename: Wouter
authors.initials: W
authors.lastname: Wieling
authors.forename: Arthur A M
authors.initials: AA
authors.lastname: Wilde
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008133:Long QT Syndrome / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D008487:Medical History Taking / Q000379:methods* / Q000706:statistics & numerical data*; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D013575:Syncope / Q000175:diagnosis* / Q000453:epidemiology*