title: Psychological impact of Crohn's disease on patients in remission: anxiety and depression risks.
abstract: BACKGROUND
  the role of anxiety and depression in CD patients in remission has been poorly investigated.
  
  
  OBJECTIVE
  the aim of the study was to evaluate the frequency of anxiety and depression symptoms in CD patients in remission, and potential factors influencing the development of these symptoms.
  
  
  METHODS
  CD patients older than 18 years in remission for at least 6 months before study entry were included. CD remission was defined as a Crohn s Disease Activity Index (CDAI) < 150 points together with C-reactive protein < 5 mg/L. A demographic questionnaire was filled in, and all patients were clinically classified. The therapy maintaining remission was also recorded. A Hospital Anxiety and Depression scale (HAD) was administered to all patients. Results are shown as OR and 95% CI, and analyzed by logistic regression.
  
  
  RESULTS
  92 consecutive patients were included (48 male, mean age 37 years, range from 18 to 71 years). One patient failed to correctly fill in the questionnaire. Anxiety and depression symptoms were present in 36 (39%) and 22 (24%) patients, respectively. Infliximab therapy was the only factor associated with anxiety (OR = 3.11; 95% CI: 1.03-9.43; p < 0.05). In contrast, the presence of depressive symptoms is less frequent in patients under infliximab therapy (OR = 0.16; 95% CI: 0.02-0.97; p < 0.05).
  
  
  CONCLUSIONS
  despite clinical remission, an important number of CD patients present with anxiety or depressive symptoms. Infliximab therapy in CD patients is associated to more anxiety but fewer depressive symptoms. CD patients in remission would probably benefit from psychological support.
authors.affiliation: Fienad Hospital Clínico Universitario, Santiago de Compostela, A Coruña, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Iglesias
authors.forename: M
authors.initials: M
authors.lastname: Barreiro de Acosta
authors.forename: I
authors.initials: I
authors.lastname: Vázquez
authors.forename: A
authors.initials: A
authors.lastname: Figueiras
authors.forename: L
authors.initials: L
authors.lastname: Nieto
authors.forename: A
authors.initials: A
authors.lastname: Lorenzo
authors.forename: J E
authors.initials: JE
authors.lastname: Domínguez-Muñoz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000453:epidemiology / Q000209:etiology*; D003424:Crohn Disease / Q000150:complications* / Q000523:psychology* / Q000628:therapy; D003863:Depression / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012074:Remission Induction; D055815:Young Adult