title: Synthesis and structure-activity relationships of gamma-carboline derivatives as potent and selective cysLT(1) antagonists.
abstract: A gamma-carboline series of cysLT(1) receptor antagonists has been prepared. Some of the compounds show good potencies both, in vitro and in vivo, compared to the standard compounds.
authors.affiliation: Laboratori de Química Orgànica, Facultat de Farmàcia, Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII s/n, 08028-Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Bonjoch
authors.forename: Faïza
authors.initials: F
authors.lastname: Diaba
authors.forename: Lluís
authors.initials: L
authors.lastname: Pagès
authors.forename: Daniel
authors.initials: D
authors.lastname: Pérez
authors.forename: Lidia
authors.initials: L
authors.lastname: Soca
authors.forename: Montserrat
authors.initials: M
authors.lastname: Miralpeix
authors.forename: Dolors
authors.initials: D
authors.lastname: Vilella
authors.forename: Paquita
authors.initials: P
authors.lastname: Anton
authors.forename: Carles
authors.initials: C
authors.lastname: Puig
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002243:Carbolines / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D006168:Guinea Pigs; D006801:Humans; D020128:Inhibitory Concentration 50; D020024:Leukotriene Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D008956:Models, Chemical; D018077:Receptors, Leukotriene / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D002243:Carbolines; D020024:Leukotriene Antagonists; D018077:Receptors, Leukotriene; C055572:gamma-carboline; C083169:leukotriene D4 receptor