title: Quantitative ex vivo and in vivo comparison of lumen dimensions measured by optical coherence tomography and intravascular ultrasound in human coronary arteries.
abstract: OBJECTIVE
  The relationship between the lumen dimensions obtained in human coronary arteries using intravascular ultrasound (IVUS) and those obtained using optical coherence tomography (OCT) is not well understood. The objectives were to compare the lumen measurements obtained ex vivo in human coronary arteries using IVUS, OCT and histomorphometry, and in vivo in patients using IVUS and OCT with and without balloon occlusion.
  
  
  METHODS
  Ex vivo study: the lumen areas of matched anatomical sections of human coronary arteries were measured using IVUS, OCT and histology. In vivo study: the lumen areas in matched sections were measured using IVUS and OCT with and without occlusion.
  
  
  RESULTS
  Ex vivo: in the eight specimens studied, the lumen area obtained using OCT and IVUS was larger than that obtained using histomorphometry: mean difference 0.8+/-1 mm(2) (28%) for OCT and 1.3+/-1.1 mm(2) (40%) for IVUS. In vivo: in the five vessels analyzed, the lumen area obtained using IVUS was larger than that obtained using OCT: mean difference 1.67+/-0.54 mm(2) (33.7%) for IVUS relative to OCT with occlusion and 1.11+/-0.53 mm(2) (21.5%) relative to OCT without occlusion. The lumen area obtained using OCT without occlusion was larger than that obtained using OCT with occlusion: mean difference 0.61+/-0.23 mm(2) (13%).
  
  
  CONCLUSIONS
  In fixed human coronary arteries, both IVUS and OCT overestimated the lumen area compared with histomorphometry. In vivo the lumen dimensions obtained using IVUS were larger than those obtained using OCT, with or without occlusion. Moreover, the OCT image acquisition technique (i.e. with or without occlusion) also had an impact on lumen measurement.
authors.affiliation: Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, Países Bajos.
authors.forename: Nieves
authors.initials: N
authors.lastname: Gonzalo
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
authors.forename: Héctor M
authors.initials: HM
authors.lastname: García-García
authors.forename: Gijs
authors.initials: G
authors.lastname: van Soest
authors.forename: Takayuki
authors.initials: T
authors.lastname: Okamura
authors.forename: Jurgen
authors.initials: J
authors.lastname: Ligthart
authors.forename: Michiel
authors.initials: M
authors.lastname: Knaapen
authors.forename: Stefan
authors.initials: S
authors.lastname: Verheye
authors.forename: Nico
authors.initials: N
authors.lastname: Bruining
authors.forename: Evelyn
authors.initials: E
authors.lastname: Regar
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology*; D004452:Echocardiography; D006801:Humans; D041623:Tomography, Optical Coherence