c-Fos expression in the supraoptic nucleus is the most intense during different durations of restraint water-immersion stress in the rat.
Restraint water-immersion stress (RWIS) can induce anxiety, hypothermia, and severe vagally-mediated gastric dysfunction. The present work explored the effects of different durations of RWIS on neuronal activities of the forebrain by c-Fos expression in conscious rats exposed to RWIS for 0, 30, 60, 120, or 180 min. The peak of c-Fos induction was distinct for different forebrain regions. The most intense c-Fos induction was always observed in the supraoptic nucleus (SON), and then in the hypothalamic paraventricular nucleus (PVN), posterior cortical amygdaloid nucleus (PCoA), central amygdaloid nucleus (CeA), and medial prefrontal cortex (mPFC). Moreover, body temperature was reduced to the lowest degree after 60 min of RWIS, and the gastric lesions tended to gradually worsen with the prolonging of RWIS duration. These data strongly suggest that these nuclei participate in the organismal response to RWIS to different degrees, and may be involved in the hypothermia and gastric lesions induced by RWIS.
Zhang
Yu-Yu
YY
Key Laboratory of Animal Resistance of Shandong Province and College of Life Sciences, Shandong Normal University, 250014, Jinan, People's Republic of China.
Zhu
Wen-Xing
WX
Cao
Guo-Hong
GH
Cui
Xi-Yun
XY
Ai
Hong-Bin
HB
D000679:Amygdala / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001007:Anxiety / Q000378:metabolism / Q000503:physiopathology; D007035:Hypothermia / Q000378:metabolism / Q000503:physiopathology; D007101:Immersion / Q000503:physiopathology*; D008297:Male; D023421:Models, Animal; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013272:Stomach Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology* / Q000523:psychology*; D013495:Supraoptic Nucleus / Q000378:metabolism* / Q000473:pathology
D016760:Proto-Oncogene Proteins c-fos