The stage of offspring of female rats after treatment with cytostatics of various groups.
We examined the offspring of female rats that were mated with intact males in the delayed period after administration of cytostatic drugs Farmorubicin, platidiam, carboplatin, etoposide, and paclitaxel (1, 3, and 6 months post-treatment). Toxicity of these drugs in the offspring decreased in the following order: paclitaxel > etoposide > carboplatin > platidiam > Farmorubicin. The toxic effect depended not only on the type of cytostatic treatment, but also on the period of conception.
Borovskaya
T G
TG
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
Perova
A V
AV
Pachomova
A V
AV
Poluektova
M E
ME
Gol'dberg
V E
VE
D000818:Animals; D016190:Carboplatin / Q000633:toxicity; D002945:Cisplatin / Q000633:toxicity; D054697:Cytostatic Agents / Q000633:toxicity*; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000633:toxicity; D005047:Etoposide / Q000633:toxicity; D005260:Female; D008297:Male; D017239:Paclitaxel / Q000633:toxicity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D054697:Cytostatic Agents; D015251:Epirubicin; D005047:Etoposide; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin