A new route to 3-acyl-2-aminobenzofurans: palladium-catalysed cycloisomerisation of 2-(cyanomethyl)phenyl esters.
Treatment of 2-(cyanomethyl)phenyl esters with a catalytic amount of Pd(OAc)(2), PCy(3), and Zn afforded 3-acyl-2-aminobenzofuran derivatives in good to excellent yields, which can be used as building blocks for the synthesis of benzofuran fused heterocycles.
Murai
Masahito
M
Department of Energy Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Miki
Koji
K
Ohe
Kouichi
K