In situ gelling polymers in ocular drug delivery systems: a review.
The review article aims to highlight the recent developments in various in situ gel-forming polymeric systems that are used to achieve prolonged contact time of drugs with the cornea and increase their ocular bioavailability. These phase-change polymers, which trigger the drug release in response to external stimuli, are the most investigated in controlled drug delivery. The present review summarizes in detail these various polymers, which undergo sol-gel transition due to physical (temperature) or chemical (pH, ions) stimuli when instilled in the eye. As a whole, this article provides valuable insight into current trends in the field of in situ gel-forming ocular drug delivery systems.
Mundada
Atish S
AS
University Department of Pharmaceutical Sciences, RTM Nagpur University, Nagpur, India. atishmundada@rediffmail.com
Avari
Jasmine G
JG
D000287:Administration, Topical; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003315:Cornea / Q000378:metabolism; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005123:Eye / Q000187:drug effects / Q000378:metabolism; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
D003692:Delayed-Action Preparations; D005782:Gels; D004364:Pharmaceutical Preparations; D011108:Polymers