title: Pidotimod: a reappraisal.
abstract: Pidotimod (Polimod ) is a synthetic dipeptide molecule with biological and immunological activity on both the adaptive and the innate immune responses. In vitro studies, both from animal and human specimens, have documented a good activity on innate and adaptive immune responses and have been confirmed by in vivo studies. These activities have been applied in clinical studies demonstrating the efficacy of pidotimod in reducing the rate of recurrent infections of the upper respiratory and urinary tracts in children. The same results were obtained in recurrent respiratory tract infections in adults. Interestingly, these effects are more evident in the setting of immune defects such as senescence, Downs syndrome, and cancer.
authors.forename: P
authors.initials: P
authors.lastname: Riboldi
authors.forename: M
authors.initials: M
authors.lastname: Gerosa
authors.forename: P L
authors.initials: PL
authors.lastname: Meroni
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000818:Animals; D002648:Child; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D011761:Pyrrolidonecarboxylic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000276:immunology; D053778:Thiazolidines / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D053778:Thiazolidines; C064893:pidotimod; D011761:Pyrrolidonecarboxylic Acid