Free fatty acid profiles in preeclampsia.
Preeclampsia has many characteristics similar to the metabolic syndrome. One of these is aberrant lipid metabolism. We studied free fatty acid (FFA) profiles at baseline and after oral glucose load in 21 preeclamptic and 11 normotensive pregnant women. Insulin sensitivity was measured by intravenous glucose tolerance test. We found that serum total FFA concentrations at baseline were 67% higher in preeclamptic than in normotensive pregnancies (P=0.0002). The difference between the two groups was largest in the concentrations of oleic (75%), linoleic (129%) and arachidonic (315%) acids. Oral intake of glucose suppressed total FFA in preeclamptic women by 40% (95% CI 32.1-46.1%, P<0.0001) but only 24% in control women (95% CI 0.01-42.0%, P=0.045). Insulin sensitivity, which in preeclamptic women was 37% lower (P=0.009), was unrelated to total or any individual FFA concentration. We concluded that preeclamptic women have higher circulating FFA concentrations, which despite insulin resistance are suppressed by oral glucose loading.
Villa
Pia M
PM
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. pia.villa@helsinki.fi
Laivuori
Hannele
H
Kajantie
Eero
E
Kaaja
Risto
R
D016718:Arachidonic Acid / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D019787:Linoleic Acid / Q000097:blood; D019301:Oleic Acid / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*
D005230:Fatty Acids, Nonesterified; D016718:Arachidonic Acid; D019301:Oleic Acid; D019787:Linoleic Acid