title: Effects on cognition of stereotactic lesional surgery for the treatment of tremor in multiple sclerosis.
abstract: OBJECTIVE
  To assess the effect of stereotactic lesional surgery for treatment of tremor in multiple sclerosis on cognition.
  
  
  METHODS
  Eleven patients (3 males, 8 females) with multiple sclerosis participated in the study. Six subjects comprised the surgical group and five the matched control group. All patients were assessed at baseline and three months using a neuropsychological test battery that included measures of intellectual ability, memory, language, perception and executive function.
  
  
  RESULTS
  There were no significant differences between the surgical and control groups and no change from pre to post testing except for a decline in scores on the Mini-Mental State Examination (MMSE), WAIS-R Digit Span and Verbal Fluency in the surgical group.
  
  
  CONCLUSIONS
  The results indicate that stereotactic lesional surgery does not result in major cognitive impairment in multiple sclerosis. However, the decline in MMSE scores, digit span and verbal fluency require further investigation in a larger sample.
authors.affiliation: Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology & Neurosurgery, London, UK. m.jahanshahi@ion.ucl.ac.uk
authors.forename: Marjan
authors.initials: M
authors.lastname: Jahanshahi
authors.forename: Socorro
authors.initials: S
authors.lastname: Pieter
authors.forename: Sundus H
authors.initials: SH
authors.lastname: Alusi
authors.forename: Catherine R G
authors.initials: CR
authors.lastname: Jones
authors.forename: Scott
authors.initials: S
authors.lastname: Glickman
authors.forename: John
authors.initials: J
authors.lastname: Stein
authors.forename: Tipu
authors.initials: T
authors.lastname: Aziz
authors.forename: Peter G
authors.initials: PG
authors.lastname: Bain
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000601:surgery*; D009483:Neuropsychological Tests; D021641:Recognition, Psychology; D012691:Serial Learning; D013028:Space Perception; D013238:Stereotaxic Techniques / Q000009:adverse effects; D013788:Thalamus / Q000601:surgery*; D016896:Treatment Outcome; D014202:Tremor / Q000150:complications / Q000601:surgery*; D014706:Verbal Learning