title: First isolation of Burkholderia tropica from a neonatal patient successfully treated with imipenem.
abstract: We report the first case of a human Burkholderia tropica infection. The patient was a premature neonate who had necrotizing enterocolitis with bowel perforation requiring surgical intervention. The stoma care and difficulties in feeding were a chronic problem. At the age of almost 4 months he developed septicemia due to B. tropica. Three consecutive blood cultures grew this organism. The organism was cleared from the blood after a course of imipenem and resolution of post-operative ileus. Our case suggests that environmental and plant pathogens can cause human infection especially in those in an immunocompromised condition.
authors.affiliation: Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia. zakuan@kb.usm.my
authors.forename: Zakuan Zainy
authors.initials: ZZ
authors.lastname: Deris
authors.forename: Hans
authors.initials: H
authors.lastname: Van Rostenberghe
authors.forename: Hassan
authors.initials: H
authors.lastname: Habsah
authors.forename: Ramli
authors.initials: R
authors.lastname: Noraida
authors.forename: Gin Ceong
authors.initials: GC
authors.lastname: Tan
authors.forename: Yean Yean
authors.initials: YY
authors.lastname: Chan
authors.forename: Abdul Rahman
authors.initials: AR
authors.lastname: Rosliza
authors.forename: Manicham
authors.initials: M
authors.lastname: Ravichandran
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D019117:Burkholderia / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D019121:Burkholderia Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D017809:Fatal Outcome; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use*; D016867:Immunocompromised Host; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem