Neuropharmacological activity of the pericarp of Passiflora edulis flavicarpa degener: putative involvement of C-glycosylflavonoids.
Passiflora edulis has been used in traditional medicine as a sedative and to treat or prevent central disorders such as anxiety and insomnia. In this study, the central effects of the aqueous extract (AE), the butanolic fraction (BF), and the aqueous residual fraction (ARF) obtained from the pericarp of P. edulis flavicarpa were investigated in mice and the possible compounds involved in these putative neuropharmacologic effects were determined. AE, BF, and ARF increased the total time spent in the light compartment of the light:dark box, an anxiolytic-like effect, and AE also potentiated the hypnotic effects of ethyl ether, a sedative effect. The thin layer chromatography and high-performance liquid chromatography analysis indicated the predominance of C-glycosylflavonoids in these extracts and fractions, which were identified as isoorientin, vicenin-2, spinosin, and 6,8-di-C-glycosylchrysin.
Sena
Ligia Moreiras
LM
Laboratory of Neuropharmacology, Department of Pharmacology - Center of Biological Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, SC, 88049-900, Brazil.
Zucolotto
Silvana Maria
SM
Reginatto
Flávio Henrique
FH
Schenkel
Eloir Paulo
EP
De Lima
Thereza Christina Monteiro
TC
D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D035264:Flowers / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D009480:Neuropharmacology; D029598:Passiflora / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy
D005419:Flavonoids; D006027:Glycosides; D010936:Plant Extracts