Passive limb movement augments ventilatory response to CO2 via sciatic inputs in anesthetized rats.
Passive limb movement (PLM) in humans induces a phasic hyperpnea, but the underlying physiological mechanisms remain unclear. We asked whether PLM in anesthetized rats would produce a similar phasic hyperpnea associated with an augmented ventilatory (V(E)) response to CO(2) that is dependent on sciatic afferents. The animals underwent 5 min threshold PLM, 3 min hypercapnia (5% CO(2)), and their combination (CO(2) exposure at the end of 2nd min of 5-min PLM) before and after bilateral transection of the sciatic nerves. We found that a threshold PLM evoked a phasic hyperpnea, similar to that denoted in humans, and an augmented V(E) response to CO(2). Both responses were greatly diminished by sciatic nerve transection. Moreover, similar responses were also evoked by electrically stimulating the central end of the transected sciatic nerve. Our findings suggest an ability of the sciatic afferents to augment the V(E) response to CO(2) that likely contributes to the PLM-induced hyperpnea.
Zhuang
Jianguo
J
Pathophysiology Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA.
Xu
Fadi
F
Zhang
Cancan
C
Frazier
Donald T
DT
D000818:Animals; D019771:Axotomy; D002245:Carbon Dioxide / Q000494:pharmacology; D005121:Extremities / Q000294:innervation / Q000502:physiology; D006935:Hypercapnia / Q000503:physiopathology; D008297:Male; D015915:Motion Therapy, Continuous Passive; D009068:Movement / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation* / Q000502:physiology; D012123:Pulmonary Ventilation / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000502:physiology*
D002245:Carbon Dioxide