title: miR-15a and miR-16-1 in cancer: discovery, function and future perspectives.
abstract: MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL.
authors.affiliation: The Lautenberg Center for General and Tumor Immunology, Hebrew University-Hadassah Medical School, Institute for Medical Research Israel-Canada, Ein Karem, P.O. Box 12272, Jerusalem 91120, Israel. aqeilan@cc.huji.ac.il
authors.forename: R I
authors.initials: RI
authors.lastname: Aqeilan
authors.forename: G A
authors.initials: GA
authors.lastname: Calin
authors.forename: C M
authors.initials: CM
authors.lastname: Croce
mesh_terms: D017209:Apoptosis / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C505361:MIRN15 microRNA, human; C505362:MIRN16 microRNA, human; D035683:MicroRNAs