A hydrophilic three side-chained triazatruxene as a new strong and selective G-quadruplex ligand.
A new hydrosoluble triazatruxene derivative (Azatrux) is reported to selectively bind to G-quadruplex DNA, as derived by ESI-MS measurements and competition experiments.
Ginnari-Satriani
Luca
L
Dipartimento di Chimica, Sapienza Università di Roma, Piazzale A. Moro 5, 00185, Roma, Italy.
Casagrande
Valentina
V
Bianco
Armandodoriano
A
Ortaggi
Giancarlo
G
Franceschin
Marco
M
D001483:Base Sequence; D001667:Binding, Competitive; D002227:Carbazoles / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D054856:G-Quadruplexes; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013379:Substrate Specificity
D002227:Carbazoles; D008024:Ligands; C543050:azutrux; D004247:DNA