title: First evidence for an anxiolytic effect of a diterpenoid from Salvia cinnabarina.
abstract: The potential anxiolytic and anti-depressive activity of CMP1 was studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMP1 on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMP1, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina.
authors.affiliation: Department of Experimental Pharmacology, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Maione
authors.forename: Maria Camela
authors.initials: MC
authors.lastname: Bonito
authors.forename: Mariantonella
authors.initials: M
authors.lastname: Colucci
authors.forename: Virginia
authors.initials: V
authors.lastname: Cozzolino
authors.forename: Angela
authors.initials: A
authors.lastname: Bisio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Romussi
authors.forename: Carla
authors.initials: C
authors.lastname: Cicala
authors.forename: Stefano
authors.initials: S
authors.lastname: Pieretti
authors.forename: Nicola
authors.initials: N
authors.lastname: Mascolo
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D027544:Salvia / Q000737:chemistry*
chemical_list: C423882:3,4-secoisopimara-4(18),7,15-triene-3-oic acid; D014151:Anti-Anxiety Agents; D004224:Diterpenes