Modafinil reinstates a cocaine conditioned place preference following extinction in rats.
The current study examined whether modafinil would reinstate an extinguished cocaine conditioned place preference (CPP). Following extinction of a cocaine CPP, rats were administered modafinil (128 mg/kg), cocaine (5 mg/kg) or vehicle and given a 60-min reinstatement test. While the effect of cocaine was transient, modafinil robustly reinstated a cocaine CPP following extinction, suggesting that modafinil may induce relapse or increase the vulnerability of addicts to the reinforcing effects of environmental triggers.
Bernardi
Rick E
RE
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA. bernardi@ohsu.edu
Lewis
Jason R
JR
Lattal
K Matthew
KM
Berger
S Paul
SP
D000704:Analysis of Variance; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004777:Environment; D005108:Extinction, Psychological / Q000187:drug effects*; D008297:Male; D000077408:Modafinil; D009043:Motor Activity / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013028:Space Perception / Q000187:drug effects; D013997:Time Factors
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D018765:Dopamine Uptake Inhibitors; D003042:Cocaine; D000077408:Modafinil