Histology of metaplasia and dysplasia in Barrett's esophagus.
The histologic diagnosis of Barrett's dysplasia requires the identification of intestinal metaplasia, which often presents a challenge due to sampling error, observer variation, and difficulty in histologic interpretation. Particularly problematic is the separation of negative, indefinite, and low-grade dysplasia, the varied histological appearances of high-grade dysplasia, and the diagnosis of suboptimal biopsy material. This article seeks to aid in the histological evaluation of metaplasia and dysplasia in Barrett's esophagus.
Yerian
Lisa
L
Hepatobiliary and Gastrointestinal Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA. yerianl@ccf.org
D000230:Adenocarcinoma / Q000209:etiology; D001471:Barrett Esophagus / Q000150:complications / Q000473:pathology*; D001706:Biopsy; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003937:Diagnosis, Differential; D004938:Esophageal Neoplasms / Q000209:etiology; D004947:Esophagus / Q000473:pathology*; D005764:Gastroesophageal Reflux / Q000150:complications; D020397:Goblet Cells / Q000473:pathology; D006651:Histocytochemistry; D006652:Histological Techniques / Q000379:methods* / Q000592:standards; D006801:Humans; D008679:Metaplasia; D009367:Neoplasm Staging; D015588:Observer Variation; D011230:Precancerous Conditions / Q000150:complications / Q000473:pathology*; D015983:Selection Bias; D012720:Severity of Illness Index