title: Ovarian fibromas with heavy deposition of hyaline globules: a diagnostic pitfall.
abstract: We report 5 patients with cellular ovarian fibromas, which contained heavy depositions of hyaline globules, a remarkable and very conspicuous histologic feature of all tumors. The hyaline globules ranged in size from 1 to 25 microm. Some cells were stuffed with myriads of small hyaline globules 1 to 3 microm in size, whereas in the other cells the globules were up to 25 microm in size. The hyaline globules were stained with periodic acid-Schiff, and were mucicarmine and Alcian blue negative. These hyaline globules were present, at least in small numbers, in all 100 hematoxylin and eosin slides reviewed from all 5 cases in this series. Often the cells containing the hyaline globules showed a signet-ring appearance in the more compact cellular areas. All the tumors in our series appear to have a benign course. The patients were without signs of recurrence and without metastasis 1, 2, 3, and 6 years after the excision of the neoplasms. Follow-up in one of the patients was not available. The distinction of the ovarian fibromas with hyaline globules from the Krukenberg tumors and yolk sac tumor is discussed in the paper.
authors.affiliation: Sikl's Department of Pathology, Bioptical Laboratory sro, Charles University Hospital, Pilsen, Czech Republic. michal@medima.cz
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
authors.forename: Denisa
authors.initials: D
authors.lastname: Kacerovska
authors.forename: Petr
authors.initials: P
authors.lastname: Mukensnabl
authors.forename: Fredrik
authors.initials: F
authors.lastname: Petersson
authors.forename: Dusan
authors.initials: D
authors.lastname: Danis
authors.forename: Marian
authors.initials: M
authors.lastname: Adamkov
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kazakov
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D018240:Endodermal Sinus Tumor / Q000473:pathology; D005260:Female; D005350:Fibroma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006818:Hyalin / Q000378:metabolism*; D007150:Immunohistochemistry; D007725:Krukenberg Tumor / Q000473:pathology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*