title: BounceBack capsules for reduction of DOMS after eccentric exercise: a randomized, double-blind, placebo-controlled, crossover pilot study.
abstract: BACKGROUND
  Delayed onset muscle soreness (DOMS) is muscle pain and discomfort experienced approximately one to three days after exercise. DOMS is thought to be a result of microscopic muscle fiber tears that occur more commonly after eccentric exercise rather than concentric exercise. This study sought to test the efficacy of a proprietary dietary supplement, BounceBack, to alleviate the severity of DOMS after standardized eccentric exercise.
  
  
  METHODS
  The study was a randomized, double-blind, placebo-controlled, crossover study. Ten healthy community-dwelling untrained subjects, ranging in age from 18-45 years, were enrolled. Mean differences within and between groups were assessed inferentially at each data collection time-point using t-tests for all outcome measures.
  
  
  RESULTS
  In this controlled pilot study, intake of BounceBack capsules for 30 days resulted in a significant reduction in standardized measures of pain and tenderness post-eccentric exercise compared to the placebo group. There were trends towards reductions in plasma indicators of inflammation (high sensitivity C-reactive protein) and muscle damage (creatine phosphokinase and myoglobin).
  
  
  CONCLUSIONS
  BounceBack capsules were able to significantly reduce standardized measures of pain and tenderness at several post-eccentric exercise time points in comparison to placebo. The differences in the serological markers of DOMS, while not statistically significant, appear to support the clinical findings. The product appears to have a good safety profile and further study with a larger sample size is warranted based on the current results.
authors.affiliation: Medicus Research LLC, Northridge, California 91325, USA. jay.udani@medicusresearch.com.
authors.forename: Jay K
authors.initials: JK
authors.lastname: Udani
authors.forename: Betsy B
authors.initials: BB
authors.lastname: Singh
authors.forename: Vijay J
authors.initials: VJ
authors.lastname: Singh
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sandoval