title: Prolonged chronic phase of greater than 10 years of chronic myelogenous leukemia in a patient with congenital human immunodefeciency virus infection.
abstract: A 15-year-old male with congenital HIV infection was diagnosed with chronic myelogenous leukemia (CML) at age 4 years 9 months. HIV was initially treated with zidovudine. For the last >10 years he has received didanosine, lamivudine, and nelfinavir. CML was treated with Interferon alfa (INF-alpha) for >10 years and a brief course of hydroxyurea (HU). He remained in chronic phase CML since diagnosis however recent molecular monitoring revealed increased BCR/ABL transcripts necessitating a change in therapy to imatinib. The very prolonged chronic phase of CML in this patient has been unexpected especially in light of the underlying congenital HIV infection.
authors.affiliation: Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio, USA.
authors.forename: Bhuvana A
authors.initials: BA
authors.lastname: Setty
authors.forename: Karen C
authors.initials: KC
authors.lastname: Hayani
authors.forename: Bruce I
authors.initials: BI
authors.lastname: Sharon
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Schmidt
mesh_terms: D000293:Adolescent; D015658:HIV Infections / Q000150:complications* / Q000151:congenital*; D006801:Humans; D015466:Leukemia, Myeloid, Chronic-Phase / Q000188:drug therapy*; D008297:Male; D013997:Time Factors