Synthesis of (11)C-labeled 2-aminoethanol via a nitroaldol reaction using nitro[(11)C]methane.
The nitroaldol reaction of nitro[(11)C]methane and formaldehyde using EtOH and EtONa efficiently provided 2-nitro[(11)C]ethanol in 3min. The nitro group reduction in the presence of NiCl(2) and NaBH(4) in MeOH followed by purification using semi-preparative HPLC using 10% EtOH aqueous solution as an eluent proved to be a practical and accessible method for the synthesis of 2-amino[2-(11)C]ethanol.
Kato
Koichi
K
Department of Molecular Probes, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-855, Japan. katok@nirs.go.jp
Zhang
Ming-Rong
MR
Minegishi
Katsuyuki
K
Suzuki
Kazutoshi
K
D002247:Carbon Isotopes / Q000737:chemistry; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009595:Nitroparaffins / Q000138:chemical synthesis / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors
D002247:Carbon Isotopes; D004983:Ethanolamines; D009595:Nitroparaffins; D019275:Radiopharmaceuticals; D008697:Methane; C008640:nitromethane