Mechanisms of penicillin antibiotic interactions with human erythrocytes.
Significant effects of penicillin antibiotics, used in pediatrics, on the erythrocyte structural characteristics were detected by recording kinetic curves of osmotic and acid hemolysis. Possible relationships between erythrocyte properties and concentrations, duration of exposure to, and structure of antibiotics were revealed. Recommendations for dose correction for effective use of antibiotics in medicine with consideration for individual features of the patient are proposed.
Kalashnikova
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Polar Alpine Botanical Gardens and Institute, Kola Research Center, Russian Academy of Sciences, Apapity, Russsia. adm@pabgi.apatity.ru
D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D010406:Penicillins / Q000494:pharmacology*
D010406:Penicillins