title: Stimulatory effects of ferulic acid on endurance exercise capacity in mice.
abstract: Ferulic acid was orally administered to mice in order to investigate its effects on exercise endurance capacity. When a single administration of ferulic acid was given to the mice in an adjustable-current water pool, the duration of exhaustive swimming was longer than that exhibited by the mice in the control group. Also, when the mice were exhaustively exercised for 3 consecutive days, no change in swimming time was found in the ferulic acid-administered group on the final day, and a large decrease in the untreated mice. Administration of ferulic acid efficiently activated the hepatic antioxidative defense system during exercise. The mice that received ferulic acid showed significant increases in the activity of hepatic antioxidant enzymes such as superoxide dismutase, catalase, and glutathione-S-transferase. Furthermore, an increased glutathione level was observed, while the malondialdehyde content was reduced. These results suggest that ferulic acid possesses stimulatory effects that can enhance exercise endurance capacity and reduce fatigue by elevating antioxidative potentials.
authors.affiliation: Department of Food and Nutrition, Chonnam National University, Gwangju, Korea.
authors.forename: Yanghee
authors.initials: Y
authors.lastname: You
authors.forename: Jeongjin
authors.initials: J
authors.lastname: Park
authors.forename: Ho-Geun
authors.initials: HG
authors.lastname: Yoon
authors.forename: Yoo-Hyun
authors.initials: YH
authors.lastname: Lee
authors.forename: Kwontack
authors.initials: K
authors.lastname: Hwang
authors.forename: Jeongmin
authors.initials: J
authors.lastname: Lee
authors.forename: Kyungmi
authors.initials: K
authors.lastname: Kim
authors.forename: Kwang-Won
authors.initials: KW
authors.lastname: Lee
authors.forename: Sangin
authors.initials: S
authors.lastname: Shim
authors.forename: Woojin
authors.initials: W
authors.lastname: Jun
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003373:Coumaric Acids / Q000494:pharmacology*; D005221:Fatigue / Q000517:prevention & control; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010805:Physical Conditioning, Animal; D010807:Physical Endurance
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D008315:Malondialdehyde; C004999:ferulic acid; D005978:Glutathione