title: Surgical therapy for Barrett's esophagus with high-grade dysplasia and early esophageal carcinoma.
abstract: Patients diagnosed with Barrett's esophagus and high-grade dysplasia may harbor an intramucosal or early stage invasive esophageal carcinoma. The presence of and associated invasive malignancy exposes the patient to the risk of lymph node metastasis and its devastating effect on survival, regardless of treatment. The authors recommend that patients diagnosed with Barrett's esophagus and highgrade dysplasia be evaluated by an esophageal surgeon, who will be able to confirm the diagnosis and review the surgical options along with their potential benefits and risks. By continuously refining minimally invasive surgical techniques and perioperative care, esophageal resection should remain an acceptable option to patients with this disease.
authors.affiliation: Division of Thoracic and Foregut Surgery, Heart, Lung and Esophageal Institute, University of Pittsburgh, 200 Lothrop Street, Suite C-800, Pittsburgh Medical Center, PA 15213, USA.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Gilbert
authors.forename: Blair A
authors.initials: BA
authors.lastname: Jobe
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D001471:Barrett Esophagus / Q000150:complications / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D055088:Early Detection of Cancer; D019160:Endosonography; D004938:Esophageal Neoplasms / Q000209:etiology / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D016629:Esophagectomy / Q000009:adverse effects / Q000379:methods* / Q000523:psychology; D004945:Esophagoscopy; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D009367:Neoplasm Staging; D019990:Perioperative Care; D011230:Precancerous Conditions / Q000601:surgery; D011300:Preoperative Care; D011788:Quality of Life; D012307:Risk Factors; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome