title: Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
abstract: Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.
authors.affiliation: Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Shuying
authors.initials: S
authors.lastname: Liu
authors.forename: Makiko
authors.initials: M
authors.lastname: Umezu-Goto
authors.forename: Mandi
authors.initials: M
authors.lastname: Murph
authors.forename: Yiling
authors.initials: Y
authors.lastname: Lu
authors.forename: Wenbin
authors.initials: W
authors.lastname: Liu
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Shuangxing
authors.initials: S
authors.lastname: Yu
authors.forename: L Clifton
authors.initials: LC
authors.lastname: Stephens
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Cui
authors.forename: George
authors.initials: G
authors.lastname: Murrow
authors.forename: Kevin
authors.initials: K
authors.lastname: Coombes
authors.forename: William
authors.initials: W
authors.lastname: Muller
authors.forename: Mien-Chie
authors.initials: MC
authors.lastname: Hung
authors.forename: Charles M
authors.initials: CM
authors.lastname: Perou
authors.forename: Adrian V
authors.initials: AV
authors.lastname: Lee
authors.forename: Xianjun
authors.initials: X
authors.lastname: Fang
authors.forename: Gordon B
authors.initials: GB
authors.lastname: Mills
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000818:Animals; D018196:Carcinoma, Adenosquamous / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D003001:Cloning, Molecular; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism / Q000473:pathology; D043264:Phosphodiesterase I / Q000235:genetics / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases / Q000235:genetics / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism; D049368:Receptors, Lysophosphatidic Acid / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D000099189:Lysophospholipase D
chemical_list: D009097:Multienzyme Complexes; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases; D011960:Receptors, Estrogen; D049368:Receptors, Lysophosphatidic Acid; D000099189:Lysophospholipase D