Progress in the development of peroxide-based anti-parasitic agents.
Progress made in the past decade pertaining to the development of anti-parasitic agents based on artemisinin is presented. Apart from discussions on important derivatives obtained through functionalization at the C-3, C-9, C-10 and O-11 positions of artemisinin, an outline on its seco analogs and artemisinin bundles are given for a broader perspective on structure-activity relationships. Success with synthetic peroxides, drug-hybrid approaches, broad-spectrum anti-infective properties of peroxide compounds and a survey on peroxide-containing natural products other than artemisinin with available biological data are included to highlight recent trends and avenues for future research. A supplementary material with details on the biological properties of a larger collection of molecules belonging to the above structural classes is also given for reference.
Muraleedharan
K M
KM
Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India. mkm@iitm.ac.in
Avery
Mitchell A
MA
D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D010272:Parasitic Diseases / Q000188:drug therapy* / Q000469:parasitology; D010545:Peroxides / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000977:Antiparasitic Agents; D037621:Artemisinins; D010545:Peroxides