title: Bilberry inhibits angiogenesis in chick chorioallontoic membrane.
abstract: Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. Bilberry has been traditionally used as a folk medicine for some countries. The purpose of the present study was to evaluate the effect of bilberry in chick chorioallantoic membrane angiogenesis model in vivo. In this well characterized model, bilberry inhibited angiogenesis in a concentration-dependent manner. Compared with the normal group, bilberry group has significant decreased vessels proliferation. These results provide evidence that bilberry inhibits angiogenesis and may be useful for treating angiogenesis-dependent human diseases.
authors.affiliation: Department of Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey. chem352000@yahoo.com
authors.forename: Taner
authors.initials: T
authors.lastname: Ozgurtas
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Aydin
authors.forename: Serkan
authors.initials: S
authors.lastname: Tapan
authors.forename: Ozgur
authors.initials: O
authors.lastname: Avci
authors.forename: M Kemal
authors.initials: MK
authors.lastname: Erbil
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology* / Q000627:therapeutic use; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000187:drug effects; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D029800:Vaccinium myrtillus
chemical_list: D020533:Angiogenesis Inhibitors; D000872:Anthocyanins; D010936:Plant Extracts; C073305:Vaccinium myrtillus extract