title: The transient relationship between pressure and volume in the pediatric pulmonary system.
abstract: An accurate understanding of the relationship between pulmonary pressure and volume is required for modeling pulmonary mechanics in a variety of clinical applications. In this study the experimental techniques and mathematical formulations used to characterize viscoelastic materials are applied to characterize transient pulmonary compliance in juvenile swine. Fixed volumes of air were insufflated into 5 swine and held constant for 45 s while the transient decay in tracheal pressure was measured. An analytical model was developed using an optimization scheme that maximized the model fit to the experimental data over the entire time convolution. The initial injected volume was varied to assess the spatial and temporal linearity of the behavior. Model performance was assessed by comparing measured and predicted pressure during insufflations of erratic volume waveforms. It is concluded that the pulmonary impedance of healthy juveniles can be adequately described over a wide volume and frequency range using a relatively simple 5-parameter model that is linear both spatially and temporally.
authors.affiliation: Center for Applied Biomechanics, University of Virginia, 1011 Linden Avenue, Charlottesville, VA 22902, USA. rwk3c@virginia.edu
authors.forename: Richard W
authors.initials: RW
authors.lastname: Kent
authors.forename: William A
authors.initials: WA
authors.lastname: Woods
authors.forename: Robert S
authors.initials: RS
authors.lastname: Salzar
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Damon
authors.forename: Cameron R
authors.initials: CR
authors.lastname: Bass
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002648:Child; D006801:Humans; D008168:Lung / Q000502:physiology; D008953:Models, Anatomic; D023421:Models, Animal; D008962:Models, Theoretical; D011312:Pressure; D012123:Pulmonary Ventilation; D012121:Respiration, Artificial / Q000379:methods; D015656:Respiratory Mechanics; D012137:Respiratory System; D013552:Swine