title: Evaluation of risk factors and severity of a life threatening surgical emergency: Fournier's gangrene (a report of 15 cases).
abstract: BACKGROUND
  Fournier's gangrene is a rare, rapidly progressive, necrotising fasciitis of the external genitalia and perineum with high morbidity and mortality.
  
  
  METHODS
  15 patients with Fournier's gangrene were enrolled. Gender, age, aetiology, predisposing factors, symptomatology, associated diseases, hospital stay, FGSI, and body surface area were analysed.
  
  
  RESULTS
  Ten males and five females were enrolled in the study. The mean age was 54 years (range 23-81). E. coli and acinetobacter were the common organisms cultured. All patients were treated with a common approach of resuscitation, broad-spectrum antibiotics, and wide surgical excision. Common predisposing factors included diabetes mellitus (73.3%), poor personal hygiene (60%), obesity (33.3%), psychosis (20%) and decubitus ulcers (13.2%). Whereas five (33.3%) patients developed synergistic gangrene of the scrotum secondary to anorectal disease, five (33.3%) had a urological source of infection. Mean BSA and FSGI scores were 15.93 +/- 3.13 and 6.02 +/- 0.95, respectively. Serum glucose > 140 mg/dl, the existence of septic shock on admission, the spread of gangrene to the perineum and abdominal wall (Groups C and D), BSA > or = 24 cm2, a cutaneous source of infection and FGSI scores > or = 7 were factors affecting mortality rates with statistical significance (p < 0.05). There was a direct correlation between the culture of mixed type micro-organisms and the cutaneous source of infection (p < 0.05). The extent of gangrene correlated with higher FGSI scores (> or = 7) (p < 0.05). Mortality and morbidity rates were as 20% (n = 3) and 60% (n = 9).
  
  
  CONCLUSIONS
  Aggressive surgical debridement and combined antibiotherapy are essential in the management of Fournier's gangrene. FGSI and BSA are useful to assess the severity and prognosis of the disease.
authors.affiliation: Department of General Surgery, Celal Bayar University, School of Medicine, Manisa, Türkiye. eraykara@hotmail.com
authors.forename: E
authors.initials: E
authors.lastname: Kara
authors.forename: T
authors.initials: T
authors.lastname: Müezzinoğlu
authors.forename: G
authors.initials: G
authors.lastname: Temeltas
authors.forename: L
authors.initials: L
authors.lastname: Dinçer
authors.forename: Y
authors.initials: Y
authors.lastname: Kaya
authors.forename: A
authors.initials: A
authors.lastname: Sakarya
authors.forename: T
authors.initials: T
authors.lastname: Coskun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015331:Cohort Studies; D003646:Debridement; D004630:Emergencies; D005260:Female; D018934:Fournier Gangrene / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents