title: Retinal horizontal cells: challenging paradigms of neural development and cancer biology.
abstract: A group of retinal interneurons known as horizontal cells has recently been shown to exhibit a variety of unique biological properties, as compared with other nerve cells, that challenge many long-standing assumptions in the fields of neural development and cancer biology. These features include their unusual migratory behavior, their unique morphological plasticity, and their propensity to divide at a relatively late stage during development. Here, we review these novel features, discuss their relevance for other cell types, outline open questions in our understanding of horizontal cell development and consider their implications.
authors.affiliation: Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. poche@bcm.edu
authors.forename: Ross A
authors.initials: RA
authors.lastname: Poché
authors.forename: Benjamin E
authors.initials: BE
authors.lastname: Reese
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D002465:Cell Movement / Q000502:physiology; D048430:Cell Shape; D005134:Eye Neoplasms / Q000378:metabolism / Q000473:pathology; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D012160:Retina / Q000166:cytology / Q000254:growth & development; D051248:Retinal Horizontal Cells / Q000166:cytology / Q000502:physiology*; D012175:Retinoblastoma / Q000378:metabolism / Q000473:pathology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D005136:Eye Proteins; D009419:Nerve Tissue Proteins; C093564:Neurogenic differentiation factor 1