Vitamins in the monkey brain: An immunocytochemical study.
Using highly specific antisera directed against vitamins, the distribution of pyridoxal-, pyridoxine-, vitamin C- and nicotinamide-immunoreactive structures in the monkey (Macaca fascicularis) brain was studied. Neither immunoreactive structures containing pyridoxine or nicotinamide, nor immunoreactive fibers containing vitamin C were found in the monkey brain. However, this work reports the first visualization and the morphological characteristics of pyridoxal- and vitamin C-immunoreactive cell bodies in the mammalian central nervous system using an indirect immunoperoxidase technique. A high density of pyridoxal-immunoreactive cell bodies was found in the paraventricular hypothalamic nucleus and in the supraoptic nucleus and a low density of the same was observed in the periventricular hypothalamic region, whereas a moderate density of vitamin C-immunoreactive cell bodies was observed in the somatosensorial cortex (precentral gyrus). Immunoreactive fibers containing pyridoxal were only visualized in the anterior commissure. The restricted distribution of pyridoxal and vitamin C in the monkey brain suggests that both vitamins could be involved in very specific physiological mechanisms.
Mangas
A
A
Institute of Neurosciences of Castilla y León (INCYL), Laboratory of Neuroanatomy of the Peptidergic Systems, Salamanca, Spain.
Coveñas
R
R
Bodet
D
D
Duleu
S
S
Marcos
P
P
Geffard
M
M
D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis / Q000378:metabolism; D001369:Axons / Q000378:metabolism / Q000648:ultrastructure; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D001923:Brain Chemistry / Q000502:physiology*; D001931:Brain Mapping; D004734:Energy Metabolism / Q000502:physiology*; D007032:Hypothalamus, Anterior / Q000166:cytology / Q000378:metabolism; D007150:Immunohistochemistry; D008252:Macaca fascicularis / Q000033:anatomy & histology / Q000378:metabolism*; D008297:Male; D009434:Neural Pathways / Q000166:cytology / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009536:Niacinamide / Q000032:analysis / Q000378:metabolism; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism; D011730:Pyridoxal / Q000032:analysis / Q000378:metabolism; D011736:Pyridoxine / Q000032:analysis / Q000378:metabolism; D014815:Vitamins / Q000032:analysis / Q000378:metabolism*
D014815:Vitamins; D009536:Niacinamide; D011730:Pyridoxal; D011736:Pyridoxine; D001205:Ascorbic Acid