title: Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse.
abstract: Brain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role in multiple sclerosis (MS) was only partially investigated. In this work, we aimed to evaluate the plasma levels of BDNF from 29 MS patients and 24 control subjects. MS patients had decreased levels of BDNF in comparison with healthy controls. BDNF levels increased significantly after MS relapse. Our results provide some evidence for the involvement of BDNF in the pathogenesis of MS and suggest a role for this neurotrophin during the recovery of acute demyelinating inflammatory lesion.
authors.affiliation: Neurology Unit, University Hospital, Federal University of Minas Gerais, Avenida Alfredo Balena, 110. Belo Horizonte, MG 30130-100, Brazil. elizcomini@yahoo.com.br
authors.forename: Elizabeth Regina Comini
authors.initials: ER
authors.lastname: Frota
authors.forename: David Henrique
authors.initials: DH
authors.lastname: Rodrigues
authors.forename: Eduardo Antonio
authors.initials: EA
authors.lastname: Donadi
authors.forename: Doralina G
authors.initials: DG
authors.lastname: Brum
authors.forename: Damacio Ramon Kaimen
authors.initials: DR
authors.lastname: Maciel
authors.forename: Antônio Lúcio
authors.initials: AL
authors.lastname: Teixeira
mesh_terms: D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood*; D012008:Recurrence; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor