Proliferation inhibition effect of docetaxel combined with cisplatin on osteosarcoma cells.
This research, studies the proliferation inhibition effect of combined use of docetaxel and cisplatin on osteosarcoma cells. The effects of docetaxel and cisplatin used alone and combined on osteosarcoma cell line HOS8603 were examined by means of cell count, morphologic observation, and flow cytometry (FCM). It was found that docetaxel and cisplatin either used alone or in combination, significantly inhibited the proliferation of osteosarcoma cells and apparently induced the apoptosis, and the effect of the combined drugs was better than that of the drugs used alone (growth inhibition ratio >or=59.34%, P < 0.05; apoptosis ratio = 18.31%, P < 0.01). Therefore, the combined use of docetaxel and cisplatin is more effective than either of the drugs used alone in inhibiting the proliferation of osteosarcoma cells.
Jin
Wei
W
Department of Orthopaedics, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China.
Cai
Lin
L
Niu
Guangfeng
G
Tao
Hai
H
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D006131:Growth Inhibitors / Q000008:administration & dosage*; D006801:Humans; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology*; D043823:Taxoids / Q000008:administration & dosage
D006131:Growth Inhibitors; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin