title: Conformationally constrained aromatic oligoamide foldamers with supersecondary structure motifs.
abstract: The design, synthesis, and structural studies of aromatic foldamers based on oligo(phenanthroline dicarboxamide)s that displayed supersecondary structure motifs have been described. Governed by a combined conformational restriction, the foldamers adopted well defined and compact 3D structures, which have been validated by UV/Vis, NMR spectra, and X-ray crystal analysis. The results presented here would offer a useful route for the de novo design of aromatic oligoamide foldamers with distinctive structural architectures.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Hai-Yu
authors.initials: HY
authors.lastname: Hu
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Xiang
authors.forename: Chuan-Feng
authors.initials: CF
authors.lastname: Chen
mesh_terms: D000577:Amides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010618:Phenanthrolines / Q000737:chemistry; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000577:Amides; D010618:Phenanthrolines; D012996:Solutions