Protective effect of tomato against adrenaline-induced myocardial infarction in rats.
Lycopene, a carotenoid rich in tomato fruit (ripe), is an effective antioxidant and free radical scavenger. In this study n-hexane extract of tomato was evaluated for its protective action against oxidative stress in experimental myocardial infarction induced by administration of adrenaline in rats. Adrenaline produced significant elevation of malondialdehyde content of heart, an indicator of lipid peroxidation, with a significant rise in serum aspartate aminotransferase (AST) level and different grades of necrotic changes in myocardium. Rats were treated with two doses of n-hexane extract of tomato, intragastrically daily for one month prior to administration of adrenaline on the 31st and 32nd day. Pretreatment of tomato extract (1 mg/kg, 2 mg/kg) and vitamin E (50 mg/kg) significantly reduced the malondialdehyde concentration in heart and significantly lowered the serum AST level in adrenaline treated rats. Myocardial necrosis was significantly prevented by pretreatment. These results suggest that n-hexane extract of tomato possesses antioxidative property that may protect heart against catecholamine induced myocardial infarction.
Parvin
Roksana
R
Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
Akhter
Nargis
N
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D002338:Carotenoids / Q000494:pharmacology / Q000627:therapeutic use*; D004837:Epinephrine / Q000633:toxicity; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D000077276:Lycopene; D018551:Solanum lycopersicum; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D009206:Myocardium / Q000737:chemistry / Q000473:pathology; D009336:Necrosis; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D016166:Free Radical Scavengers; D010936:Plant Extracts; D014810:Vitamin E; D002338:Carotenoids; D008315:Malondialdehyde; D001219:Aspartate Aminotransferases; D000077276:Lycopene; D004837:Epinephrine