title: The stage of offspring of female rats after treatment with cytostatics of various groups.
abstract: We examined the offspring of female rats that were mated with intact males in the delayed period after administration of cytostatic drugs Farmorubicin, platidiam, carboplatin, etoposide, and paclitaxel (1, 3, and 6 months post-treatment). Toxicity of these drugs in the offspring decreased in the following order: paclitaxel > etoposide > carboplatin > platidiam > Farmorubicin. The toxic effect depended not only on the type of cytostatic treatment, but also on the period of conception.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
authors.forename: T G
authors.initials: TG
authors.lastname: Borovskaya
authors.forename: A V
authors.initials: AV
authors.lastname: Perova
authors.forename: A V
authors.initials: AV
authors.lastname: Pachomova
authors.forename: M E
authors.initials: ME
authors.lastname: Poluektova
authors.forename: V E
authors.initials: VE
authors.lastname: Gol'dberg
mesh_terms: D000818:Animals; D016190:Carboplatin / Q000633:toxicity; D002945:Cisplatin / Q000633:toxicity; D054697:Cytostatic Agents / Q000633:toxicity*; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000633:toxicity; D005047:Etoposide / Q000633:toxicity; D005260:Female; D008297:Male; D017239:Paclitaxel / Q000633:toxicity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D054697:Cytostatic Agents; D015251:Epirubicin; D005047:Etoposide; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin