Pharmacokinetic study of a carbamazepine nanoemulsion in beagle dogs.
This work describes the pharmacokinetics of a novel carbamazepine nanoemulsion. The plasma concentration profiles were determined in beagle dogs after i.v. bolus administration of a 5 mg/kg carbamazepine nanoemulsion and compared to the corresponding carbamazepine/hydroxypropyl-beta-cyclodextrin complex solution. Both formulations showed similar pharmacokinetic profiles and could represent valuable formulations in case of emergencies, when a rapid action in the central nervous system is desirable.
Kuminek
Gislaine
G
Programa de Pós-Graduação em Farmácia, Centro de Ciências da Saúde, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, 88.040-900 Florianópolis, SC, Brazil.
Kratz
Jadel M
JM
Ribeiro
Rodrigo
R
Kelmann
Regina G
RG
de Araújo
Bibiana V
BV
Teixeira
Helder F
HF
Simões
Cláudia M O
CM
Koester
Letícia S
LS
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002220:Carbamazepine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004285:Dogs; D004655:Emulsions; D005079:Excipients / Q000737:chemistry*; D005260:Female; D007275:Injections, Intravenous; D053758:Nanoparticles; D011897:Random Allocation; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000927:Anticonvulsants; D004655:Emulsions; D005079:Excipients; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002220:Carbamazepine