title: An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms.
abstract: In recent years, improvements in experimental techniques and enhancements in computing power have revolutionized our understanding of the mechanisms of protein folding. By combining insights gained from theory, experiment and simulation we are moving toward an atomistic view of folding landscapes. Future challenges involve exploiting the knowledge gained and methods developed to enable us to elucidate a molecular description of folding dynamics in the complex environment of the cell.
authors.affiliation: Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK.
authors.forename: Alice I
authors.initials: AI
authors.lastname: Bartlett
authors.forename: Sheena E
authors.initials: SE
authors.lastname: Radford
mesh_terms: D002942:Circular Dichroism; D019277:Entropy; D031541:Fluorescence Resonance Energy Transfer; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins