title: Biophysical and structural studies on the capsid protein of the human immunodeficiency virus type 1: a new drug target?
abstract: New therapeutic agents are necessary against HIV due to the rapid emergence of drug-resistant variants of the virus, which has yielded therapeutic strategies partially ineffective. Assembly can be considered as a good target for antivirals since it depends only on repetitive weak protein-protein interactions, and probably disruption of a small part of these interactions is sufficient to suppress infectivity in a dominant-negative effect. We propose the capsid protein of HIV-1 as a potential candidate.
authors.affiliation: Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Elche (Alicante) 03202, Spain. jlneira@umh.es
authors.forename: José L
authors.initials: JL
authors.lastname: Neira
mesh_terms: D036022:Capsid Proteins / Q000737:chemistry*; D019281:Dimerization; D015195:Drug Design; D015497:HIV-1 / Q000378:metabolism*; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding
chemical_list: D036022:Capsid Proteins