title: Antisecretory factor-inducing therapy improves the clinical outcome in patients with Ménière's disease.
abstract: CONCLUSIONS
  Intake of antisecretory factor (AF)-inducing SPC-flakes significantly reduced vertigo in patients suffering from Ménière's disease (MD). The positive effect may be due to a modulation of the transport of water and ions in the endolymphatic space.
  
  
  OBJECTIVE
  To evaluate the effects of a 3-month treatment period with SPC-flakes in patients suffering from MD.
  
  
  METHODS
  A prospective, double-blind, placebo-controlled study was performed. A total of 51 adult patients with MD were included in the study: 27 subjects treated with SPC-flakes and 24 subjects with control cereals. The patients received SPC-flakes or control cereals (1 g per kg body weight per 24 h in two servings) for 3 months. Otoneurological examinations were carried out before and after this period.
  
  
  RESULTS
  The severity of MD was classified according to the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) grading system. Fourteen of the 27 patients randomized to intake of the AF-inducing SPC-flakes reported decreased vertigo, compared with 2 of 24 in the control group (p < 0.001). No consistent change in the otoneurological examinations could be demonstrated in any of the groups of patients.
authors.affiliation: Department of Audiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Hanner
authors.forename: Helge
authors.initials: H
authors.lastname: Rask-Andersen
authors.forename: Stefan
authors.initials: S
authors.lastname: Lange
authors.forename: Eva
authors.initials: E
authors.lastname: Jennische
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003051:Cochlea / Q000378:metabolism / Q000503:physiopathology; D004311:Double-Blind Method; D002523:Edible Grain; D004712:Endolymphatic Sac / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D009479:Neuropeptides / Q000378:metabolism*; D011446:Prospective Studies; D014717:Vertigo / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy
chemical_list: D009479:Neuropeptides; C049628:antisecretory factor