Microsatellite instability and HPV genotype in Polish women with cervical cancer.
BACKGROUND
Human papillomaviruses (HPVs) are associated with anogenital cancer. Little is known about the prevalence of microsatellite instability (MSI) in cervical cancer. The aim of this study was to investigate the incidence of microsatellite instability in cervical cancer and to see whether there is a relation between MSI, HPV and clinicopathological characteristics in the study population.


RESULTS
Using three assays (pU1M/2R, GP5+/6+ and E6-nested multiplex PCR) HPV was detected in 110 out of 113 patients with histologically confirmed cervical cancer. The presence of MSI was investigated in 95 of the 113 cases using seven microsatellite loci. In total, 12 out of the 95 patients (12.6%) showed MSI. None of clinicopathological parameters showed a significant difference between microsatellite stable and MSI cases.


CONCLUSIONS
In this population of Polish cervical cancer patients, 12.6% showed microsatellite instability. There was no correlation between MSI positivity and clinicopathological parameters and/or survival.
Baay
M F D
MF
Department of Medical Oncology, University of Antwerp (UA/UZA), Antwerp, Belgium. marc.baay@ua.ac.be
Nakonieczny
M
M
Wozniak
I
I
Deschoolmeester
V
V
Liss
J
J
Lukaszuk
K
K
Sotlar
K
K
Emerich
J
J
Vermorken
J B
JB
D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D006801:Humans; D053842:Microsatellite Instability; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications*; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000821:virology
D004279:DNA, Viral