title: Erythropoietin and erythropoiesis.
abstract: Although the concept of a humoral regulator of erythropoiesis was introduced more than 100 years ago, its existence was first firmly established a little more than 50 years ago. This review briefly describes the historical development of information about erythropoietin. It then describes our current understanding of where erythropoietin is produced; the factors that regulate its rate of production; how erythropoietin acts at the cellular level to stimulate erythropoiesis; and its role in the regulation of the rate of erythropoiesis. Finally, it discusses the clinical uses of erythropoietin in the diagnosis and therapy of hematopoietic diseases.
authors.affiliation: Oncology Specialists, Park Ridge, IL 60068, USA. fried_walt@hotmail.com
authors.forename: Walter
authors.initials: W
authors.lastname: Fried
mesh_terms: D000818:Animals; D004920:Erythropoiesis; D004921:Erythropoietin / Q000378:metabolism* / Q000627:therapeutic use*; D006402:Hematologic Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans
chemical_list: D004921:Erythropoietin