title: Nukacin ISK-1, a bacteriostatic lantibiotic.
abstract: We determined the mode of action of nukacin ISK-1. It did not cause membrane potential dissipation or the efflux of ATP or K(+) ions from the cells of a sensitive bacterial strain; however, it blocked the membrane depolarization activity of nisin. Nukacin ISK-1-treated cells had single arrangements of cells without the formation of a complete septum. A remarkable reduction in cell wall width was also observed, but cytoplasmic content was unaffected. We concluded that nukacin ISK-1 is bacteriostatic.
authors.affiliation: Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Sikder M
authors.initials: SM
authors.lastname: Asaduzzaman
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Nagao
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Zendo
authors.forename: Jiro
authors.initials: J
authors.lastname: Nakayama
authors.forename: Kenji
authors.initials: K
authors.lastname: Sonomoto
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D001430:Bacteriocins / Q000737:chemistry / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D046529:Microscopy, Electron, Transmission; D008954:Models, Biological; D009561:Nisin / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; C421186:nukacin ISK-1; D009561:Nisin; C102526:nisin A