title: Inner retinal layer thinning in Parkinson disease.
abstract: OBJECTIVE
  To quantify retinal thickness in patients with Parkinson disease (PD).
  
  
  METHODS
  Forty-five eyes of 24 PD patients and 31 eyes of 17 control subjects underwent a comprehensive ophthalmologic examination. We used optical coherence tomography to examine retinal thickness, separately quantifying the inner and outer retinal layers. Intraocular pressure was measured by Goldmann applanation tonometry.
  
  
  RESULTS
  The mean (SD) ages of the patients with PD and healthy subjects were 64.0 (6.5) years vs 63.5 (10.7) years (P = .77). The mean (SD) intraocular pressure was 13.6 (+/-2.7) mm Hg in the PD patients. No difference was found in either the superior or inferior outer retinal layer thickness of PD vs control eyes. The mean (SD) superior inner retinal layer thickness of PD vs control eyes was 88.79 (11.3) microm vs 103.5 (24.3) microm (P = .01), and the mean inferior inner retinal layer thickness was 89.83 (11.1) microm vs 104.0 (23.5) microm (P = .01).
  
  
  CONCLUSIONS
  The inner retinal layer is significantly thinner in PD patients than in healthy subjects. Idiopathic PD, distinct from glaucoma, needs to be considered in the differential diagnosis of retinal nerve fiber layer thinning.
authors.affiliation: Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA.
authors.forename: Mohammedyusuf E
authors.initials: ME
authors.lastname: Hajee
authors.forename: Wayne F
authors.initials: WF
authors.lastname: March
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Lazzaro
authors.forename: Arthur H
authors.initials: AH
authors.lastname: Wolintz
authors.forename: Eric M
authors.initials: EM
authors.lastname: Shrier
authors.forename: Sofya
authors.initials: S
authors.lastname: Glazman
authors.forename: Ivan G
authors.initials: IG
authors.lastname: Bodis-Wollner
mesh_terms: D003937:Diagnosis, Differential; D005583:Fourier Analysis; D005901:Glaucoma / Q000175:diagnosis; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D010300:Parkinson Disease / Q000175:diagnosis*; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014794:Visual Fields