[Regulation of vesicular transport by membrane curvature].
A cellular membrane is highly deformable: during the last decade, numerous studies have dissected at the molecular scale how during vesicular transport various proteins could deform a membrane or recognize membrane deformation. We will discuss how the activity of ArfGAP1 and GMAP-210, two proteins involved in vesicular transport, is regulated by membrane curvature thanks to an ALPS motif. Since a membrane is not solely defined by its shape but also by its lipids composition, we will show how others proteins are adapted to other lipid compositions to recognize membrane shape.
Drin
Guillaume
G
Université de Nice Sophia Antipolis et CNRS, Institut de Pharmacologie moléculaire et cellulaire, UMR, Valbonne, France. drin@ipmc.cnrs.fr
Bigay
Joëlle
J
Antonny
Bruno
B
D020816:Amino Acid Motifs; D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D022181:COP-Coated Vesicles / Q000502:physiology / Q000648:ultrastructure; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure*; D048430:Cell Shape / Q000502:physiology*; D020690:GTPase-Activating Proteins / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism / Q000648:ultrastructure; D008560:Membrane Fluidity; D008561:Membrane Fusion / Q000502:physiology; D008563:Membrane Lipids / Q000502:physiology; D026901:Membrane Transport Proteins / Q000378:metabolism; D020559:Monomeric GTP-Binding Proteins / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D022161:Transport Vesicles / Q000502:physiology* / Q000648:ultrastructure
D020690:GTPase-Activating Proteins; D008563:Membrane Lipids; D026901:Membrane Transport Proteins; D009687:Nuclear Proteins; D020559:Monomeric GTP-Binding Proteins