title: Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
abstract: This work describes the synthesis and anti-inflammatory properties of a pentadienone derivative, HB2. The treatment with HB2 produced anti-oedematogenic, anti-inflammatory and antinociception without change locomotors performance. Finally, HB2 reduced the nitric oxide and prostaglandin E(2) production on RAW 264.7 cells stimulated with LPS without changing the cell viability. Taken together, our results show, for the first time, that HB2 can modulate the inflammatory response when administered to mice.
authors.affiliation: Grupo de Pesquisa e Desenvolvimento de Biomedicamentos (BIOMED), Universidade Bandeirante de São Paulo, São Paulo, Brazil. niraldop@yahoo.com.br
authors.forename: Niraldo
authors.initials: N
authors.lastname: Paulino
authors.forename: Naiara Carvalho
authors.initials: NC
authors.lastname: Rodrigues
authors.forename: Paulo Celso
authors.initials: PC
authors.lastname: Pardi
authors.forename: José Agustín Pablo Quincoces
authors.initials: JA
authors.lastname: Suárez
authors.forename: Reginaldo Pereira
authors.initials: RP
authors.lastname: dos Santos
authors.forename: Amarilis
authors.initials: A
authors.lastname: Scremin
authors.forename: Christian
authors.initials: C
authors.lastname: Vogel
authors.forename: Holger
authors.initials: H
authors.lastname: Feist
authors.forename: Dirk
authors.initials: D
authors.lastname: Michalik
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000840:Anisoles / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015232:Dinoprostone / Q000378:metabolism; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: C543314:1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one; D000700:Analgesics; D000840:Anisoles; D000893:Anti-Inflammatory Agents; D007659:Ketones; D016328:NF-kappa B; D009569:Nitric Oxide; D015232:Dinoprostone