title: Review of contemporaneous mycosis fungoides and B-cell malignancy at Mayo Clinic.
abstract: BACKGROUND
  Having either mycosis fungoides or B-cell lymphoma may predispose a patient to the other.
  
  
  OBJECTIVE
  We sought to determine whether the contemporaneous occurrence of the two malignancies is greater than chance and to investigate possible risk factors for the second malignancy.
  
  
  METHODS
  We retrospectively reviewed the records of patients with contemporaneous mycosis fungoides and B-cell lymphoma seen between 1990 and 2007 at Mayo Clinic, Rochester, MN, or at Mayo Clinic, Scottsdale, AZ.
  
  
  RESULTS
  In all, 23 patients had contemporaneous mycosis fungoides and B-cell malignancy. The first diagnosis was mycosis fungoides in 10 patients and B-cell lymphoma in 7; in 6 patients, the diseases were diagnosed simultaneously. No therapeutic factors could account for a predisposition to a second malignancy.
  
  
  CONCLUSIONS
  Retrospective design, referral center, and small sample size are limitations.
  
  
  CONCLUSIONS
  Mycosis fungoides and B-cell lymphoma are unlikely to occur contemporaneously by chance, but no factor obviously predisposes a patient with one malignancy to development of the second.
authors.affiliation: College of Medicine, Mayo Clinic, Scottsdale, Arizona 85259, USA.
authors.forename: Elise
authors.initials: E
authors.lastname: Herro
authors.forename: David J
authors.initials: DJ
authors.lastname: Dicaudo
authors.forename: Mark D P
authors.initials: MD
authors.lastname: Davis
authors.forename: Amy L
authors.initials: AL
authors.lastname: Weaver
authors.forename: David L
authors.initials: DL
authors.lastname: Swanson
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D001707:Biopsy, Needle; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D016393:Lymphoma, B-Cell / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D016410:Lymphoma, T-Cell, Cutaneous / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate