title: [An operative case of ulcerative colitis associated with hyperthyroidism].
abstract: We encountered a rare operative case of hyperthyroidism followed by ulcerative colitis (UC). A 26-year-old mam was referred to our department to undergo an operation. We suspected the possible complication of adrenal insufficiency, since he suffered from severe weight loss, a high fever and palpitation on admission. We diagnosed hyperthyroidism, however, based on the presence of high serum free T3 and T4 levels and a decreased TSH level. After improving the symptoms and the thyroid function by administering thiamazole, we then performed a total proctocolectomy. Although a high rate of association of autoimmune thyroid diseases with UC has been suggested, only 9 cases of hyperthyroidism coexisting with UC have so far been reported in Japan. A common immunological process has been suggested to be implicated in the pathogenesis of this association, however, the exact mechanism needs to be elucidated in the future.
authors.affiliation: Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Postgraduate School of Medicine. atsushikoh@surg1.med.tohoku.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kohyama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Funayama
authors.forename: Kouhei
authors.initials: K
authors.lastname: Fukushima
authors.forename: Chikashi
authors.initials: C
authors.lastname: Shibata
authors.forename: Koh
authors.initials: K
authors.lastname: Miura
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ueno
authors.forename: Iwao
authors.initials: I
authors.lastname: Sasaki
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hiwatashi
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications / Q000601:surgery*; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications*; D008297:Male