[Psychopharmacotherapy of the elderly].
Pharmacokinetic and pharmacodynamic changes related to aging and age-associated disorders influence the choice and dosage of psychotropic drugs in the treatment of the elderly. Renal and hepatic clearance is limited and the sensitivity to pharmacological effects is increased. To avoid side effects most psychotropic drugs should be introduced in a 'start low--go slow' approach. The final dose may also be lower than in the treatment of younger adults. Drug interactions may occur as a consequence of a complex medication. Peculiarities of the treatment of older adults with antidepressants, antipsychotics, anxiolytics, mood-stabilizers and hypnotics is described.
Wollmer
M Axel
MA
Universitäre Psychiatrische Kliniken Basel, Basel. marcaxel.wollmer@upkbs.ch
Müller-Spahn
Franz
F
D000367:Age Factors; D000368:Aged; D001921:Brain / Q000187:drug effects; D015897:Comorbidity; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004347:Drug Interactions; D006801:Humans; D055118:Medication Adherence; D001523:Mental Disorders / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D008657:Metabolic Clearance Rate / Q000502:physiology; D011619:Psychotropic Drugs / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics
D011619:Psychotropic Drugs