Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles.
In this work, we report the synthesis and characterization of new compounds derived from benzothiazoles and thiadiazoles. We observed that structural modifications on these skeletons affected the antioxidant activity. Thiol and aminothiol compounds derived from thiadiazoles and benzothiazoles showed an interesting antioxidant property. The radioprotective activity has also been evaluated in mice. Some of these compounds could be good radioprotectors.
Cressier
Damien
D
Laboratoire Hétérochimie Fondamentale et Appliquée, UMR 5069-CNRS/UPS, Université Paul Sabatier, 118, route de Narbonne, 31062 Toulouse Cedex 9, France.
Prouillac
Caroline
C
Hernandez
Pierre
P
Amourette
Christine
C
Diserbo
Michel
M
Lion
Claude
C
Rima
Ghassoub
G
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D052160:Benzothiazoles / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D005720:Gamma Rays; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D013830:Thiadiazoles / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
D000975:Antioxidants; D052160:Benzothiazoles; D011837:Radiation-Protective Agents; D013830:Thiadiazoles