Dry powder nasal vaccines as an alternative to needle-based delivery.
Drug delivery to the nasal cavity has been achieved using a variety of systems. Dry powder vaccines offer the advantages of chemical and physical stability in comparison to liquid formulations. An intranasal vaccine can elicit both a local and systemic immune response. Mucoadhesive compounds can extend the residence time for powder formulations on the nasal mucosa, potentially increasing the immune response. Manufacture and characterization of a formulation containing particles of a dry powder vaccine are discussed.
Hickey
Anthony J
AJ
School of Pharmacy, The University of North Carolina, Chapel Hill, NC 27599-7360, USA. ahickey@unc.edu
Garmise
Robert J
RJ
D000281:Administration, Intranasal; D000818:Animals; D002626:Chemistry, Pharmaceutical; D006801:Humans; D009296:Nasal Cavity / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism; D011208:Powders; D014611:Vaccination / Q000379:methods*; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology
D011208:Powders; D014612:Vaccines