title: Alumina-on-alumina total hip arthroplasty in young patients: diagnosis is more important than age.
abstract: Total hip arthroplasty (THA) in young patients has a high loosening rate, due in part to acetabular deformities that may compromise bone fixation and polyethylene wear. We therefore asked whether wear or osteolysis and loosening differ in patients under 40 years of age with alumina-on-alumina THA compared to those who are older. We prospectively followed 56 patients (63 hips) younger than 40 years (Group 1) and 247 patients (274 hips) older than 40 (Group 2) who had an alumina-on-alumina THA. The minimum followup was 4 years (mean, 5.6 years; range, 4-9 years). The two groups differed in various features: there were no patients with primary osteoarthritis in Group 1 and they had worse preoperative function and range of mobility, while weight, activity level, and implant size were greater in Group 2. The survival rate for cup loosening at 80 months postsurgery was 90.8% (95% confidence interval, 82.9-98.6%) for Group 1 and 96.5% (95% confidence interval, 94.2-98.7%) for Group 2. Cup loosening was less frequent with primary osteoarthritis than with severe developmental dysplasia of the hip. Although an alumina-on-alumina THA provided similar midterm survival and radiographic loosening in both age groups, the preoperative diagnosis seems more important than age for outcome. Continued followup will be required to determine if the alumina-on-alumina bearings in young patients result less risk of osteolysis and loosening.
authors.affiliation: Hospital La Paz. P Castellana 261, 28046, Madrid, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Garcia-Rey
authors.forename: Ana
authors.initials: A
authors.lastname: Cruz-Pardos
authors.forename: Eduardo
authors.initials: E
authors.lastname: Garcia-Cimbrelo
mesh_terms: D000328:Adult; D000368:Aged; D000537:Aluminum Oxide; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation*; D005260:Female; D005500:Follow-Up Studies; D006618:Hip Dislocation, Congenital / Q000473:pathology / Q000601:surgery*; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000473:pathology / Q000601:surgery*; D010014:Osteolysis / Q000517:prevention & control; D011446:Prospective Studies; D011475:Prosthesis Failure
chemical_list: D000537:Aluminum Oxide