title: Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens.
abstract: Two new 20,24-bishomo-25-norscalaranes, compounds 1 and 2, and two new and two known 20,24-bishomoscalaranes, compounds 3-6, have been isolated from the Indonesian marine sponge Carteriospongia foliascens. The structures of 1-6 were determined by spectroscopic analysis. Compounds 1 and 3-6 inhibit RCE-protease activity.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, BC, Canada.
authors.forename: David E
authors.initials: DE
authors.lastname: Williams
authors.forename: Irwin
authors.initials: I
authors.lastname: Hollander
authors.forename: Larry
authors.initials: L
authors.lastname: Feldberg
authors.forename: Eileen
authors.initials: E
authors.lastname: Frommer
authors.forename: Robert
authors.initials: R
authors.lastname: Mallon
authors.forename: Akbar
authors.initials: A
authors.lastname: Tahir
authors.forename: Rob
authors.initials: R
authors.lastname: van Soest
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000818:Animals; D010450:Endopeptidases / Q000187:drug effects; D006801:Humans; D007214:Indonesia; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D011480:Protease Inhibitors; D054830:Sesterterpenes; D010450:Endopeptidases; C491326:RCE1 protein, human