[Organic nitrates: still interesting after all these years].
Organic nitrates remain among the oldest and most commonly employed drugs in cardiology. Despite that, the mechanisms of action, pharmacology, and, most importantly, side effects, were described only recently. We believe that all physicians should be aware of these lines of evidence. Further studies are necessary to evaluate the impact of nitrate therapy on mortality and morbidity. Paradoxically, more than 150 years after introduction in the market, these data are not yet available. The present review focuses on the recent findings in this field and on future lines of research.
Lisi
Monica
M
Parker
John D
JD
Gori
Tommaso
T
D000787:Angina Pectoris / Q000188:drug therapy; D000818:Animals; D004361:Drug Tolerance; D005609:Free Radicals; D006321:Heart / Q000187:drug effects; D006331:Heart Diseases / Q000188:drug therapy*; D006333:Heart Failure / Q000188:drug therapy; D006439:Hemodynamics / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D015201:Meta-Analysis as Topic; D009203:Myocardial Infarction / Q000188:drug therapy; D009566:Nitrates / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic; D017382:Reactive Oxygen Species; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*
D005609:Free Radicals; D009566:Nitrates; D017382:Reactive Oxygen Species; D014665:Vasodilator Agents; D005996:Nitroglycerin