Parotid mucosa-associated lymphoid tissue lymphoma regression after Helicobacter pylori eradication.
A 60-year-old woman with Sjögren's syndrome showed recurrence of parotid mucosa-associated lymphoid tissue (MALT) lymphoma with a simultaneous increase of serum sIL-2R antigen levels 10 years after surgical treatment. Helicobacter pylori infection had been detected in the stomach since the beginning of the lymphoma. Although H. pylori was not detected in the recurrent parotid lymphoma, antibiotic therapy contributed not only to successful eradication of gastric H. pylori but also to disappearance of the recurrent lymphoma. Further studies on the mechanisms of occurrence of extragastric MALT lymphomas are needed to establish the treatment of extragastric MALT lymphomas.
Iwai
Hiroshi
H
Department of Otolaryngology, Takii Hospital, Kansai Medical University, Osaka, Japan. iwai@takii.kmu.ac.jp
Nakamichi
Naoto
N
Nakae
Kaori
K
Konishi
Masaya
M
Inaba
Muneo
M
Hoshino
Shoichi
S
Baba
Susumu
S
Amakawa
Ryuichi
R
D000658:Amoxicillin / Q000008:administration & dosage; D001707:Biopsy, Needle; D017291:Clarithromycin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D009092:Mucous Membrane / Q000382:microbiology / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D009853:Omeprazole / Q000008:administration & dosage; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000601:surgery; D011877:Radionuclide Imaging / Q000379:methods; D035583:Rare Diseases; D018570:Risk Assessment; D016896:Treatment Outcome
D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole