title: SNCA variants are associated with increased risk for multiple system atrophy.
abstract: To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome-wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 x 10(-12); odds ratio 6.2) [corrected].
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA. scholzs@mail.nih.gov
authors.forename: Sonja W
authors.initials: SW
authors.lastname: Scholz
authors.forename: Henry
authors.initials: H
authors.lastname: Houlden
authors.forename: Claudia
authors.initials: C
authors.lastname: Schulte
authors.forename: Manu
authors.initials: M
authors.lastname: Sharma
authors.forename: Abi
authors.initials: A
authors.lastname: Li
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
authors.forename: Anna
authors.initials: A
authors.lastname: Melchers
authors.forename: Reema
authors.initials: R
authors.lastname: Paudel
authors.forename: J Raphael
authors.initials: JR
authors.lastname: Gibbs
authors.forename: Javier
authors.initials: J
authors.lastname: Simon-Sanchez
authors.forename: Coro
authors.initials: C
authors.lastname: Paisan-Ruiz
authors.forename: Jose
authors.initials: J
authors.lastname: Bras
authors.forename: Jinhui
authors.initials: J
authors.lastname: Ding
authors.forename: Honglei
authors.initials: H
authors.lastname: Chen
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Traynor
authors.forename: Sampath
authors.initials: S
authors.lastname: Arepalli
authors.forename: Ryan R
authors.initials: RR
authors.lastname: Zonozi
authors.forename: Tamas
authors.initials: T
authors.lastname: Revesz
authors.forename: Janice
authors.initials: J
authors.lastname: Holton
authors.forename: Nick
authors.initials: N
authors.lastname: Wood
authors.forename: Andrew
authors.initials: A
authors.lastname: Lees
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Oertel
authors.forename: Ullrich
authors.initials: U
authors.lastname: Wüllner
authors.forename: Stefano
authors.initials: S
authors.lastname: Goldwurm
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Pellecchia
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: Olaf
authors.initials: O
authors.lastname: Riess
authors.forename: Hubert H
authors.initials: HH
authors.lastname: Fernandez
authors.forename: Ramon L
authors.initials: RL
authors.lastname: Rodriguez
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
authors.forename: Werner
authors.initials: W
authors.lastname: Poewe
authors.forename: Gregor K
authors.initials: GK
authors.lastname: Wenning
authors.forename: John A
authors.initials: JA
authors.lastname: Hardy
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Singleton
authors.forename: Francesca
authors.initials: F
authors.lastname: Del Sorbo
authors.forename: Susanne
authors.initials: S
authors.lastname: Schneider
authors.forename: Kailash P
authors.initials: KP
authors.lastname: Bhatia
authors.forename: Thomas
authors.initials: T
authors.lastname: Gasser
mesh_terms: D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D019578:Multiple System Atrophy / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012306:Risk; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: C497604:SNCA protein, human; D051844:alpha-Synuclein