title: Apoptosis in the colonic crypt, colorectal adenomata, and manipulation by chemoprevention.
abstract: This review discusses the biology and the methods of assessment of apoptosis, of which, the monoclonal antibody M30 would seem to be the most useful; the role of apoptosis in the etiology of colorectal cancer; and its use as a marker to monitor the beneficial effects of chemopreventative interventions to reduce the development of colorectal cancer within the context of clinical trials.
authors.affiliation: Endoscopy Department, St George's Hospital, London, UK. njw@medix-uk.com
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: West
authors.forename: Edward D J
authors.initials: ED
authors.lastname: Courtney
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Poullis
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Leicester
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D000911:Antibodies, Monoclonal; D017209:Apoptosis / Q000502:physiology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D018890:Chemoprevention / Q000379:methods; D002986:Clinical Trials as Topic; D003106:Colon / Q000378:metabolism / Q000473:pathology; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control*; D006801:Humans; D051379:Mice; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor