title: [The molecular-genetic aspects of tubercular infection forecasting and immunotherapy].
abstract: In article is presented, the analysis of the data of the literature and own researches, concerning molecular-genetic mechanisms of antimycobacterial immunity infringements. The role of the factors defining features of a current and an outcome of a tubercular infection, namely of immunity system condition, feature of infecting microbic Mycobacterium tuberculosis strain biological properties (a genotype, a spectrum of drag sensitivity/resistance), influence of combined antitubercular chemotherapy is disc issed. The opinion is expressed that the given factors are necessary for taking into consideration for working out methodology the personalised preventive maintenance and correction of immunity infringements during pulmonary tuberculosis.
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskiĭ
authors.forename: O V
authors.initials: OV
authors.lastname: Voronkova
authors.forename: O I
authors.initials: OI
authors.lastname: Urazova
authors.forename: I O
authors.initials: IO
authors.lastname: Naslednikova
authors.forename: A K
authors.initials: AK
authors.lastname: Strelis
authors.forename: R R
authors.initials: RR
authors.lastname: Khasanova
authors.forename: V A
authors.initials: VA
authors.lastname: Serebriakova
authors.forename: E G
authors.initials: EG
authors.lastname: Churina
authors.forename: O V
authors.initials: OV
authors.lastname: Kolokolova
authors.forename: T E
authors.initials: TE
authors.lastname: Budkina
authors.forename: N P
authors.initials: NP
authors.lastname: Pirogova
authors.forename: E L
authors.initials: EL
authors.lastname: Nikulina
authors.forename: N A
authors.initials: NA
authors.lastname: Sukhalentseva
authors.forename: A E
authors.initials: AE
authors.lastname: Kolosova
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics / Q000276:immunology; D007167:Immunotherapy; D018664:Interleukin-12 / Q000276:immunology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics; D011379:Prognosis; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D014376:Tuberculosis / Q000235:genetics / Q000276:immunology* / Q000382:microbiology / Q000628:therapy*
chemical_list: D000995:Antitubercular Agents; D016207:Cytokines; D018664:Interleukin-12