Neopterin and C-reactive protein in the course of Stevens-Johnson syndrome: report of a case.
We describe a patient originally suffering from a depressive syndrome who developed Stevens-Johnson syndrome after 12 days of treatment with lamotrigine. The clinical symptoms and the inflammation parameters neopterin and C-reactive protein were documented. Neopterin values showed a good correlation with the course of the disease, which, to the best of our knowledge, has not been reported previously. C-reactive protein followed the neopterin curve with a delay of 4 days. Since neopterin is a widely available parameter it should be considered as a routine measurement in this type of hyperergic reaction. It might help to identify the beginning, the maximum and the regression of the disease in order to support therapeutic decisions.
Bertram
Linda
L
Department of Anaesthesiology/Department of Palliative Medicine, RWTH Aachen University, Pauwelsstrasse 30, USA. lbertram@ukaachen.de
Liss
Yvonne
Y
Grözinger
Michael
M
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000627:therapeutic use; D001706:Biopsy; D002097:C-Reactive Protein / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008803:Mianserin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D008875:Middle Aged; D000078785:Mirtazapine; D019798:Neopterin / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D020280:Sertraline / Q000009:adverse effects / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000097:blood* / Q000139:chemically induced* / Q000473:pathology; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D000929:Antidepressive Agents, Tricyclic; D002097:C-Reactive Protein; D000077213:Lamotrigine; D008803:Mianserin; D000078785:Mirtazapine; D019798:Neopterin; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline; D014227:Triazines