Antihyperglycaemic activity of alpha-amyrin acetate in rats and db/db mice.
The article reveals the antihyperglycaemic activity of the alpha-amyrin acetate (alpha-AA) isolated from the aerial roots of the Ficus bengalensis in normal and diabetic rats and model of type-2 diabetes, i.e. db/db mice. The oral administration of alpha-AA significantly improved the diabetic condition in streptozotocin-induced diabetic rats and in diabetic db/db mice at 50 mg kg(-1) dose level.
Singh
A B
AB
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Yadav
D K
DK
Maurya
R
R
Srivastava
A K
AK
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004195:Disease Models, Animal; D030681:Ficus / Q000737:chemistry; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008055:Lipids; D010936:Plant Extracts; D009828:Oleanolic Acid; C036380:beta-amyrin