title: [Effectiveness and safety of erlotinib in 2 patients with carcinoma of the cervix].
abstract: OBJECTIVE
  To assess the effectiveness and safety of the use of erlotinib in the treatment of refractory cervical cancer after retrospective analysis of two clinical cases.
  
  
  METHODS
  The clinical records were assessed for the patients who started treatment with erlotinib, on a compassionate-use basis, with an oral dosage of 150 mg/day until June 2008. The pharmacy dispensing records were also assessed to evaluate adherence to treatment. Progression-free survival was assessed and adverse reactions were recorded in the medical records.
  
  
  RESULTS
  Three patients with recurrent, advanced cervical cancer were candidates for treatment with erlotinib, two of whom were only starting treatment. In both cases, the women had previously received between 3 and 4 different treatment lines. Progression-free survival was 6 months and 4 months in each case. The adverse reactions to the treatment were slight.
  
  
  CONCLUSIONS
  Erlotinib presented some similar results to those obtained from cisplatin doublets in women with refractory cervical cancer, with minor adverse effects. However, these results need to be corroborated in the clinical studies field on a wider section of the population.
authors.affiliation: Servicio de Farmacia, Hospital Reina Sofía, Córdoba, España. iperezrodrigo@hotmail.com
authors.forename: I
authors.initials: I
authors.lastname: Pérez Rodrigo
authors.forename: R
authors.initials: R
authors.lastname: Albornoz López
authors.forename: M
authors.initials: M
authors.lastname: Soto Rojas
authors.forename: I
authors.initials: I
authors.lastname: Fernández García
authors.forename: V
authors.initials: V
authors.lastname: Torres Degayón
mesh_terms: D000368:Aged; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D000069347:Erlotinib Hydrochloride; D005260:Female; D006801:Humans; D008875:Middle Aged; D011799:Quinazolines / Q000627:therapeutic use*; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D011799:Quinazolines; D000069347:Erlotinib Hydrochloride; D066246:ErbB Receptors