Synthesis and structural revision of symbiodinolide C23-C34 fragment.
Stereoselective synthesis of the C23-C34 fragment of symbiodinolide, which possesses the originally proposed stereochemistry, and its diastereomers was achieved in 19 steps from L-aspartic acid, respectively. Comparison of spectroscopic data of the synthetic products with those of the degraded product of symbiodinolide led to a structural revision of the C23-C34 fragment.
Murata
Takeshi
T
Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan.
Sano
Masayuki
M
Takamura
Hiroyoshi
H
Kadota
Isao
I
Uemura
Daisuke
D
D001224:Aspartic Acid / Q000737:chemistry*; D002384:Catalysis; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D047028:Macrocyclic Compounds; C544635:symbiodinolide; D001224:Aspartic Acid