Finding one's niche in the skin.
Skin epithelia must rejuvenate constantly during normal homeostasis and repair damage after wounding. Fulfilling these roles necessitates reservoirs of stem cells that persist for life. This review focuses on the elusive stem cell niche of the epidermis, long thought to reside within the basal layer that is sandwiched between the basement membrane and the suprabasal interface.
Fuchs
Elaine
E
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. fuchslb@mail.rockefeller.edu
D000818:Animals; D004847:Epithelial Cells; D006706:Homeostasis; D006801:Humans; D012867:Skin / Q000166:cytology*; D055153:Stem Cell Niche / Q000166:cytology / Q000502:physiology*; D014945:Wound Healing