title: The developmental course of anxiety symptoms during adolescence: the TRAILS study.
abstract: BACKGROUND
  Little is known about the development of anxiety symptoms from late childhood to late adolescence. The present study determined developmental trajectories of symptoms of separation anxiety disorder (SAD), social phobia (SoPh), generalized anxiety disorder (GAD), panic disorder (PD), and obsessive-compulsive disorder (OCD) in a large prospective community cohort.
  
  
  METHODS
  Anxiety symptoms were assessed in a community sample of 2220 boys and girls at three time-points across a 5-year interval. The Revised Child Anxiety and Depression Scale (RCADS) was used to assess anxiety symptoms, and multilevel growth-curve analyses were performed.
  
  
  RESULTS
  All subtypes of anxiety first showed a decrease in symptoms (beta for age ranged from -.05 to -.13, p < .0001), followed by a leveling off of the decrease, and a subsequent slight increase in symptoms (beta for age-squared ranged from .006 to .01, p < .0001) from middle adolescence (GAD, SoPh, SAD) or late adolescence (PD and OCD) onwards. This increase in anxiety symptoms could not be explained by a co-occurring increase in depression symptoms. Girls had more anxiety symptoms than boys, and this difference remained stable during adolescence (p < .0001). Gender differences were strongly attenuated by adjustment for symptoms of depression.
  
  
  CONCLUSIONS
  The current study shows that, in the general population, anxiety symptoms first decrease during early adolescence, and subsequently increase from middle to late adolescence. These findings extend our knowledge on the developmental course of anxiety symptoms during adolescence. This is the first study to separate the development of anxiety symptoms from that of symptoms of depression.
authors.affiliation: Department of Child and Adolescent Psychiatry, Erasmus Medical Center, 3000 CB Rotterdam, The Netherlands. f.vanoort@erasmusmc.nl
authors.forename: F V A
authors.initials: FV
authors.lastname: Van Oort
authors.forename: K
authors.initials: K
authors.lastname: Greaves-Lord
authors.forename: F C
authors.initials: FC
authors.lastname: Verhulst
authors.forename: J
authors.initials: J
authors.lastname: Ormel
authors.forename: A C
authors.initials: AC
authors.lastname: Huizink
mesh_terms: D000293:Adolescent; D041923:Adolescent Development; D001008:Anxiety Disorders / Q000453:epidemiology* / Q000209:etiology; D001010:Anxiety, Separation / Q000453:epidemiology / Q000209:etiology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008960:Models, Psychological; D009426:Netherlands / Q000453:epidemiology; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000209:etiology; D016584:Panic Disorder / Q000453:epidemiology / Q000209:etiology; D010698:Phobic Disorders / Q000453:epidemiology / Q000209:etiology; D011446:Prospective Studies; D012307:Risk Factors