Synergistic effect of carbapenem-teicoplanin combination during severe Rhodococcus equi pneumonia in a kidney transplant recipient.
Rhodococcus equi is a bacterial pathogen of domestic animals that can infect immunocompromised patients, especially those with impaired cellular immunity, such as transplant recipients. No standard treatment has been established, but therapy must be prolonged, as relapses are common and can occur at the initial site or distant locations. Here we report a case of R. equi-associated pulmonary abscess in a renal transplant recipient successfully treated with a combination of carbapenem and teicoplanin. This combination was shown to be synergistic. It has minimal side effects in transplant recipients and appears to be an effective initial treatment for this severe infection.
El Karoui
K
K
Centre d'Infectiologie Necker Pasteur, Paris, France.
Guillet
C
C
Sekkal
N
N
Lanternier
F
F
Méchaï
F
F
Hue
K
K
Hiesse
C
C
Mamzer Bruneel
M-F
MF
Catherinot
E
E
Viard
J-P
JP
Mainardi
J-L
JL
Lecuit
M
M
Ferroni
A
A
Lortholary
O
O
D000193:Actinomycetales Infections / Q000188:drug therapy* / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015780:Carbapenems / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008169:Lung Abscess / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D016929:Rhodococcus equi / Q000187:drug effects*; D012720:Severity of Illness Index; D017334:Teicoplanin / Q000627:therapeutic use*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D017334:Teicoplanin