Influence of selected HLA tissue compatibility antigens on the course and efficacy of viral hepatitis C treatment--actual knowledge position.
Hepatitis C virus (HCV) infection is a common problem. Combined treatment with interferon and ribavirin improved treatment efficacy, but still high percentage of infected patients has not reached virus elimination. It was found that HCV infection course, but also treatment efficacy among other things can depend on patient's individual factors, including MHC genes structure for HLA tissue compatibility antigens. Many connections between HLA system and HCV infection course were noted. There are some reports concerning connections between MHC structure and results of chronic hepatitis C treatment with interferon. In future, results of investigations connected with this problem can allow to verify qualification criteria for treatment with alpha-interferon, because actual knowledge position has been too inconspicuous to have practical significance.
Łoś-Rycharska
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The Chair and Department of Paediatrics, Allergology and Gastroenterology, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland. klped@cm.umk.pl
Szaflarska-Popławska
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D000998:Antiviral Agents / Q000627:therapeutic use; D018450:Disease Progression; D004359:Drug Therapy, Combination; D055317:Evidence-Based Practice; D006680:HLA Antigens / Q000235:genetics / Q000502:physiology*; D006239:Haplotypes; D016174:Hepacivirus / Q000187:drug effects*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D008285:Major Histocompatibility Complex / Q000502:physiology; D012254:Ribavirin / Q000627:therapeutic use; D016896:Treatment Outcome
D000998:Antiviral Agents; D006680:HLA Antigens; D012254:Ribavirin; D007372:Interferons