Histone lysine methylation in genomic imprinting.
Genomic imprinting is an epigenetic phenomenon that causes parent-of-origin-specific expression of a small subset of genes in mammals. DNA methylation is believed to be the primary epigenetic signal that controls genomic imprinting. These methylation imprints are established during gametogenesis in male and female germ cells and maintained and interpreted during embryogenesis and in somatic tissues. Based on recent studies, histone lysine methylation plays an important role in the regulation of imprinted gene expression and, more intriguingly, may also be involved in the establishment and maintenance of DNA methylation imprints. In this point of view, we discuss these studies and their implications.
Ciccone
David N
DN
Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
Chen
Taiping
T
D000818:Animals; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000378:metabolism; D019175:DNA Methylation; D000090205:DNA Methyltransferase 3A; D044127:Epigenesis, Genetic; D005260:Female; D018392:Genomic Imprinting; D005854:Germ Cells / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism*; D008297:Male; D008745:Methylation; D051379:Mice; D008957:Models, Genetic; D012097:Repressor Proteins / Q000502:physiology
D006657:Histones; D012097:Repressor Proteins; C501529:Zfp-57 protein, mouse; C498796:Dnmt3l protein, mouse; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A; D008239:Lysine