Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy.
OBJECTIVE
This paper presents the results of one of two eight-week dentin hypersensitivity clinical studies in which the efficacy of a novel toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride as sodium monofluorophosphate (MFP) was compared to that of a benchmark commercial toothpaste containing 2% potassium ion, dosed as 3.75% potassium chloride, and 1450 ppm fluoride as sodium fluoride (NaF).


METHODS
An eight-week clinical study, with eighty patients, was conducted in Rome, Italy using a double-blind, stratified, two-treatment design. Tactile sensitivity assessments, as well as air blast sensitivity assessments, were used to compare the efficacy of the two products.


RESULTS
This clinical study showed that the new toothpaste containing 8.0% arginine and 1450 ppm fluoride as MFP in a calcium carbonate base provided a significant reduction in dentin hypersensitivity when used over a period of eight weeks. The study also showed that this new arginine toothpaste provided significantly greater reductions (p < 0.05) in dentin hypersensitivity in response to tactile (37.0%, 30.0%, and 12.2%) and air blast (23.9%, 32.0%, and 29.3%) stimuli than the commercial sensitive toothpaste containing 2% potassium ion and 1450 ppm fluoride as NaF in a silica base, after two weeks, four weeks, and eight weeks of product use, respectively.


CONCLUSIONS
A new toothpaste containing 8.0% arginine calcium carbonate, and 1450 ppm fluoride as sodium monofluorophosphate (MFP) provides significantly increased dentin hypersensitivity relief (p < 0.05) compared to a commercial sensitive toothpaste containing 2% potassium ion after two weeks, four weeks, and eight weeks of product use.
Docimo
Raffaella
R
University of Rome at Tor Vergata, Department of Odonto Stomatology (Cattedra Di Pedodonzia), Rome, Italy.
Montesani
Luigi
L
Maturo
Paulo
P
Costacurta
Micaela
M
Bartolino
Michela
M
DeVizio
William
W
Zhang
Yun Po
YP
Cummins
Diane
D
Dibart
Serge
S
Mateo
Luis R
LR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000388:Air; D001120:Arginine / Q000008:administration & dosage / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000517:prevention & control*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000008:administration & dosage / Q000627:therapeutic use*; D011188:Potassium / Q000627:therapeutic use*; D011189:Potassium Chloride / Q000008:administration & dosage / Q000627:therapeutic use; D012384:Rome; D012822:Silicon Dioxide; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D014100:Toothpastes / Q000627:therapeutic use*; D014110:Touch; D016896:Treatment Outcome; D055815:Young Adult
D004338:Drug Combinations; D010710:Phosphates; D014100:Toothpastes; C012980:fluorophosphate; D011189:Potassium Chloride; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides; D011188:Potassium