Decrease in serum levels of advanced glycation end-products by short-term lifestyle modification in non-diabetic middle-aged females.
BACKGROUND
Advanced glycation end products (AGEs) play an important role in development of atherosclerosis in diabetes and uremic diseases. However, there is currently little information available on the effects of lifestyle modification on circulating AGEs in subjects without these diseases.


METHODS
Serum levels of Nepsilon-(carboxymethyl) lysine (CML), pentosidine, derivatives of reactive oxygen metabolites (d-ROMs), adipokines, and renal function were determined in forty-seven middle-aged females. Among them, seventeen participated in a 12-week lifestyle modification (LM) program and twelve age-matched subjects were assigned to a control group. The LM program consisted of an initial educational session and encouragement.


RESULTS
At baseline, serum HDL-cholesterol was correlated with CML level (P=0.003), whereas body fat mass (P=0.012) and fat consumption (P=0.007) were correlated with pentosidine levels. After intervention, significant reductions were observed in the LM group in body fat, serum HDL-cholesterol, CML, and pentosidine. Of note, in the LM group, average number of steps in daily walking was significantly correlated with decrease in CML level (P=0.044). Decrease in pentosidine level exhibited significant positive correlations with reduction in body weight (P=0.007) and body fat mass (P=0.038).


CONCLUSIONS
The present findings suggest lifestyle modification as a promising approach to reducing circulating AGE levels even in healthy middle-aged females with neither overt diabetes nor renal dysfunction.
Yoshikawa
Takahiro
T
Department of Sports Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan. tkhr6719@med.osaka-cu.ac.jp
Miyazaki
Aiko
A
Fujimoto
Shigeo
S
D050154:Adiposity; D000328:Adult; D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D001835:Body Weight; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000097:blood*; D015444:Exercise; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008019:Life Style; D008239:Lysine / Q000031:analogs & derivatives / Q000097:blood; D008875:Middle Aged; D012044:Regression Analysis; D013997:Time Factors; D016138:Walking
D017127:Glycation End Products, Advanced; C048496:N(6)-carboxymethyllysine; D001120:Arginine; C062187:pentosidine; D008239:Lysine