Predicting node positivity in gastric cancer from gene expression profiles.
Lymphovascular invasion (LVI) in gastric cancer is readily demonstrated pre-operatively by mucosal biopsy during endoscopy, which can also provide samples for gene expression profiling. We have examined gene expression associated with lymphovascular invasion in a cohort of gastric cancer patients and have developed a 28-gene predictor of tumor aggressiveness for forecasting risk of node positivity (N+), which could potentially be useful pre-operatively. The resulting model's ranking of increasing tumor aggressiveness correlated positively with N+ status, reaching statistical significance, and was three times the correlation of LVI with N+ status.
Korenberg
Michael J
MJ
Department of Electrical and Computer Engineering, Queen's University, Kingston, Ontario K7L 3N6, Canada. korenber@queensu.ca
Dicken
Bryan J
BJ
Damaraju
Sambasivarao
S
Graham
Kathryn
K
Cass
Carol E
CE
D014408:Biomarkers, Tumor; D020869:Gene Expression Profiling; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor