PTPRR, cerebellum, and motor coordination.
Tyrosine phosphorylation is a powerful mechanism of modulation for proliferation, differentiation, and functioning of neurons. The protein products of the neuronal mouse gene PTPRR are physiological regulators of mitogen-activated protein kinase (MAPK) activities. PTPRR(-/-) mice display deficits of motor coordination and balance skills. PTPRR gene orthologues are found in many vertebrates. Recent observations suggest that the human episodic ataxia 2 (EA2) and spinocerebellar ataxia types 6 (SCA6), 12 (SCA12), and 14 (SCA14) might be associated with impaired phosphorylation levels of cerebellum calcium channels and receptors. The concept that MAPK signaling is a key process in tuning synaptic plasticity in cerebellar circuits is now emerging, with numerous implications for understanding cerebellar functions and cerebellar disorders.
Schmitt
Ina
I
Department of Neurology, UKB Bonn, Bonn, Germany.
Bitoun
Emmanuelle
E
Manto
Mario
M
D000818:Animals; D020013:Calcium Signaling / Q000235:genetics; D002524:Cerebellar Ataxia / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology; D002526:Cerebellar Diseases / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D002531:Cerebellum / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D020935:MAP Kinase Signaling System / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics; D009473:Neuronal Plasticity / Q000235:genetics; D010766:Phosphorylation / Q000235:genetics; D054634:Receptor-Like Protein Tyrosine Phosphatases, Class 7 / Q000235:genetics*
D054634:Receptor-Like Protein Tyrosine Phosphatases, Class 7