Drug-induced Brugada syndrome.
Brugada syndrome is an inherited cardiac arrhythmia condition characterized by (i) coved ST-elevation and J point elevation of at least 2 mm in at least two of the right precordial ECG leads (V1-V3) and (ii) ventricular arrhythmias, syncope, and sudden death. Patients with Brugada syndrome or suspected mutation carriers can have normal ECG recordings at other times. In these cases, a diagnostic challenge with a sodium channel blocker such as ajmaline, flecainide, or pilsicainide may induce the full-blown type 1 ECG pattern and support the diagnosis. However, recently, many other pharmacological agents not related to class I anti-arrhythmic agents have been reported to induce Brugada ECG patterns including tricyclic antidepressants, fluoxetine, lithium, trifluoperazine, antihistamines, and cocaine. As published reports of the drug-induced Brugada sign have become increasingly prevalent, there is growing interest in the mechanisms responsible for this acquired ECG pattern and its clinical significance. It is possible that drug-induced Brugada syndrome may be due to an individual susceptibility that favours drug-induced ECG abnormalities, possibly as a result of an increase in a latent ion channel dysfunction similar to that in drug-induced long QT syndrome. However, further evidence is needed to confirm this postulation. In this paper, we will review the cases and evidence of drug-induced Brugada syndrome reported in the literature.
Yap
Yee Guan
YG
Department of Cardiology, Heart and Lung Centre, Prince Court Medical Centre, 39, Jalan Kia Peng, Kuala Lumpur 50450, Malaysia. ygyap@aol.com
Behr
Elijah R
ER
Camm
A John
AJ
D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D053840:Brugada Syndrome / Q000139:chemically induced* / Q000517:prevention & control*; D002316:Cardiotonic Agents / Q000009:adverse effects*; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans
D000889:Anti-Arrhythmia Agents; D002316:Cardiotonic Agents