title: Determinant factors of renal failure after coronary artery bypass grafting with on-pump technique.
abstract: OBJECTIVE
  The aim of the present study was to investigate the determinant factors of acute renal failure (ARF) after isolated on-pump coronary artery bypass grafting (CABG).
  
  
  METHODS
  This was a retrospective study of 13,315 adult patients who underwent isolated CABG with cardiopulmonary bypass (CPB) in Tehran Heart Center from May 2002 to May 2007. The exclusion criteria were age <18, concomitant cardiac and/or noncardiac surgical operations, history of renal failure before surgery, and chronic renal failure requiring dialysis. Preoperative and operative variables were measured, and a multivariate logistic regression model was constructed to identify the independent risk factors for developing renal failure after on-pump CABG.
  
  
  RESULTS
  Of the 13,315 patients, 3,347 (25.4%) and 90,883 (74.6%) were females and males, respectively, with a mean age of 58.63 +/- 9.48 years. ARF was detected in 85 (0.6%) of the patients with isolated on-pump CABG. The mean age of the patients was 58.63 +/- 9.48 years, and 25.5% of them were female. The multivariate logistic regression analysis identified age (OR = 1.035; p = 0.002), female gender (OR = 1.622; p = 0.037), history of peripheral vascular disease (PVD) (OR = 2.579; p = 0.042), diabetes mellitus (OR = 1.918; p < 0.001), emergent and urgent surgery (OR = 1.744 and OR = 7.901, respectively; p = 0.003), CPB time >70 min (OR = 1.944; p = 0.007), and intra-aortic balloon pump (IABP) insertion (OR = 10.181; p < 0.001) as the independent risk factors for ARF.
  
  
  CONCLUSIONS
  The data showed that age, female gender, positive history of diabetes and PVD, urgent and emergent surgery, CPB time >70 min, and need for IABP were the independent determinant factors of ARF after on-pump CABG.
authors.affiliation: Department of Cardiovascular Surgery, Medical Sciences, Tehran Heart Center, University of Tehran, North Kargar Street, Tehran, Iran. dr.ahmadi2006@yahoo.com
authors.forename: Hossein
authors.initials: H
authors.lastname: Ahmadi
authors.forename: Abbasali
authors.initials: A
authors.lastname: Karimi
authors.forename: Saeed
authors.initials: S
authors.lastname: Davoodi
authors.forename: Namvar
authors.initials: N
authors.lastname: Movahedi
authors.forename: Mehrab
authors.initials: M
authors.lastname: Marzban
authors.forename: Kyomars
authors.initials: K
authors.lastname: Abbasi
authors.forename: Abbas
authors.initials: A
authors.lastname: Salehi Omran
authors.forename: Mahmud
authors.initials: M
authors.lastname: Shirzad
authors.forename: Seyed Hesameddin
authors.initials: SH
authors.lastname: Abbasi
authors.forename: Mokhtar
authors.initials: M
authors.lastname: Tazik
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000367:Age Factors; D000368:Aged; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors