[Relationship between micro-lymphatic vessel density and lymphatic metastasis in follicular thyroid carcinoma].
OBJECTIVE
To investigate the relationship between micro-lymphatic vessel density (MLVD) and lymphatic metastasis in follicular thyroid carcinoma (FTC).


METHODS
MLVD and micro-vascular density (MVD) were determined and counted by Envision immunohistochemistry using D2-40 and CD34 monoclonal antibodies in 35 specimens of follicular thyroid carcinoma(FTC)and 20 of nodular goiter. The relationship between MLVD and lymphatic metastasis was analyzed.


RESULTS
MLVD and MVD in follicular thyroid carcinoma were closely related with lymphatic metastasis. At the same time, the cancer embolus in the micro-lymphatic vessel was significantly related with the lymphatic metastasis (P<0.01).


CONCLUSIONS
The metastasis process of follicular thyroid carcinoma (FTC) is associated with the formation of the micro-lymphatic vessel and micro-vascular. Inhibition of the lymphatics formation may be a potential therapeutic maneuver for thyroid neoplasms in the future.
Deng
Hai-jun
HJ
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Huang
Xiang-cheng
XC
Han
Shu-ling
SL
Ding
Gui-po
GP
D018263:Adenocarcinoma, Follicular / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D058846:Antibodies, Monoclonal, Murine-Derived; D018952:Antigens, CD34 / Q000032:analysis / Q000276:immunology; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018952:Antigens, CD34; C500987:monoclonal antibody D2-40