title: Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood.
abstract: BACKGROUND
  Mathematical description of biological reaction networks by differential equations leads to large models whose parameters are calibrated in order to optimally explain experimental data. Often only parts of the model can be observed directly. Given a model that sufficiently describes the measured data, it is important to infer how well model parameters are determined by the amount and quality of experimental data. This knowledge is essential for further investigation of model predictions. For this reason a major topic in modeling is identifiability analysis.
  
  
  RESULTS
  We suggest an approach that exploits the profile likelihood. It enables to detect structural non-identifiabilities, which manifest in functionally related model parameters. Furthermore, practical non-identifiabilities are detected, that might arise due to limited amount and quality of experimental data. Last but not least confidence intervals can be derived. The results are easy to interpret and can be used for experimental planning and for model reduction.
  
  
  BACKGROUND
  An implementation is freely available for MATLAB and the PottersWheel modeling toolbox at http://web.me.com/andreas.raue/profile/software.html.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Physics Institute, University of Freiburg, 79104 Freiburg, Germany. andreas.raue@me.com
authors.forename: A
authors.initials: A
authors.lastname: Raue
authors.forename: C
authors.initials: C
authors.lastname: Kreutz
authors.forename: T
authors.initials: T
authors.lastname: Maiwald
authors.forename: J
authors.initials: J
authors.lastname: Bachmann
authors.forename: M
authors.initials: M
authors.lastname: Schilling
authors.forename: U
authors.initials: U
authors.lastname: Klingmüller
authors.forename: J
authors.initials: J
authors.lastname: Timmer
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D008954:Models, Biological; D011336:Probability