Novel extreme homozygote haplotypes at the human caveolin 1 gene upstream purine complex in sporadic Alzheimer's disease.
Aberrant expression of the caveolin-1 (CAV1) gene is associated with Alzheimer's disease (AD) brain. We have recently reported a polymorphic purine stretch located at between 1.8 and 1.5 kb flanking the CAV1 gene, whose alleles and genotypes are associated with late-onset AD. Extra-short homozygote haplotypes were observed that were present only in the AD cases. Following an independent case/control study, we report alleles at the other extreme of the allele range, haplotypes of which were observed to be homozygous across the region in the AD cases. We propose that there is a window for the length of motifs and haplotypes in the controls. Homozygosity for shorter and longer motifs and haplotypes was linked with AD in our study. Our findings elucidate novel predisposing haplotypes at the CAV1 gene purine complex, and confirm the role of this region in the etiopathophysiology of late-onset AD.
Zarif Yeganeh
M
M
Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Mirabzadeh
A
A
Khorram Khorshid
H R
HR
Kamali
K
K
Heshmati
Y
Y
Gozalpour
E
E
Veissy
K
K
Olad Nabi
M
M
Najmabadi
H
H
Ohadi
M
M
D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D051242:Caveolin 1 / Q000235:genetics*; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D011687:Purines / Q000378:metabolism*
D051242:Caveolin 1; D011687:Purines