betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses.
We found that betaCaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse; a protocol that induced synaptic depression in wild-type mice resulted in synaptic potentiation in Camk2b knockout mice and vice versa. These findings provide us with unique experimental insight into the mechanisms that transduce graded calcium signals into either synaptic depression or potentiation.
van Woerden
Geeske M
GM
Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hoebeek
Freek E
FE
Gao
Zhenyu
Z
Nagaraja
Raghavendra Y
RY
Hoogenraad
Casper C
CC
Kushner
Steven A
SA
Hansel
Christian
C
De Zeeuw
Chris I
CI
Elgersma
Ype
Y
D000818:Animals; D019703:Calcineurin / Q000378:metabolism; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000235:genetics / Q000378:metabolism*; D016572:Cyclosporine / Q000494:pharmacology; D004558:Electric Stimulation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000187:drug effects / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D018408:Patch-Clamp Techniques; D011689:Purkinje Cells / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D004791:Enzyme Inhibitors; D016572:Cyclosporine; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; C517672:Camk2b protein, mouse; D019703:Calcineurin