title: Left ventricular systolic function is abnormal in diastolic heart failure: re-assessment of systolic function using cardiac time interval analysis.
abstract: OBJECTIVE
  The purpose of this study was to re-assess the left ventricular (LV) systolic function in diastolic heart failure (DHF) using Doppler echocardiography.
  
  
  BACKGROUND
  Systolic function in DHF is defined as the preserved LV ejection fraction (EF). EF may not fully reflect the systolic function in DHF, especially in the presence of abnormalities during the isovolumetric contraction time (ICT).
  
  
  METHODS
  We examined LV systolic and diastolic function in 80 consecutive patients with DHF, 30 patients with asymptomatic diastolic dysfunction (ADD), and 30 normal subjects (Control). The LV and left atrial volumes, LV EF, LV ICT, and isovolumetric relaxation time (IRT), early diastolic mitral flow velocity, systolic mitral annular velocity (S'), and early diastolic mitral annular velocity were obtained.
  
  
  RESULTS
  LV ICT in DHF (69+/-30 ms) was significantly increased compared to those with ADD (37+/-23 ms) and Control (35+/-26 ms) (P<0.0001). ICT in ADD was equal to that in Control. The LV end-diastolic volume index in DHF (49+/-14 ml/m(2)) was significantly increased compared to those with ADD (42+/-12 ml/m(2)) and Control (43+/-8 ml/m(2)) (P<0.05). S' in DHF (5.9+/-1.4 cm/s) and ADD (6.7+/-1.1 cm/s) was significantly decreased compared to that in Control (8.7+/-2.5 cm/s).
  
  
  CONCLUSIONS
  Our results revealed that the major differences between ADD and DHF were global and longitudinal LV systolic dysfunction and LV enlargement. This study suggests that LV systolic dysfunction plays an important role in the development of DHF.
authors.affiliation: Department of Cardiovascular, Respiratory and Metabolic Medicine, Kagoshima University, Kagoshima City, Japan.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Kono
authors.forename: Akira
authors.initials: A
authors.lastname: Kisanuki
authors.forename: Kunitsugu
authors.initials: K
authors.lastname: Takasaki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakashiki
authors.forename: Toshinori
authors.initials: T
authors.lastname: Yuasa
authors.forename: Eiji
authors.initials: E
authors.lastname: Kuwahara
authors.forename: Naoko
authors.initials: N
authors.lastname: Mizukami
authors.forename: Takeshi
authors.initials: T
authors.lastname: Uemura
authors.forename: Kayoko
authors.initials: K
authors.lastname: Kubota
authors.forename: Nami
authors.initials: N
authors.lastname: Ueya
authors.forename: Masaaki
authors.initials: M
authors.lastname: Miyata
authors.forename: Chuwa
authors.initials: C
authors.lastname: Tei
mesh_terms: D000368:Aged; D015150:Echocardiography, Doppler; D005260:Female; D054144:Heart Failure, Diastolic / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D013599:Systole; D013997:Time Factors; D016277:Ventricular Function, Left