title: Association of depressive phenotype with affective family history is mediated by affective temperaments.
abstract: Increasing data support an association of cyclothymic temperament with bipolarity, but our knowledge about the relationship of affective temperaments (ATs) to depressive symptoms based on inheritance in a non-clinical population is limited. The aim of this article was to demonstrate how ATs and affective family history relate to the depressive symptoms in a general population. Subjects comprised 501 Hungarian adults who completed a background questionnaire, the TEMPS-A, the Zung Self-Rating Depression Scale (ZSDS) and the depression subscale of the Brief Symptom Inventory (BSI-D). Stepwise linear regression was performed to analyse the role of ATs and affective family history (AFH(0) and AFH(1)) in the variance of ZSDS and BSI-D scores. Cyclothymic, depressive and anxious temperaments have a significant role in the explained variance of depression scores, and they are all significantly related to AFH(1). Significant differences were found between AFH(1) and AFH(0) groups in ZSDS and BSI-D scores, and these effects were eliminated if ATs were entered as covariates. The probability of having any dominant temperament was more than two-fold in group AFH(1) compared with AFH(0) (OR=2.33). Our results suggest that a crucial part of inherited factors of depression is mediated by affective temperaments.
authors.affiliation: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary. lazaryjudit@yahoo.com
authors.forename: Judit
authors.initials: J
authors.lastname: Lazary
authors.forename: Xenia
authors.initials: X
authors.lastname: Gonda
authors.forename: Anita
authors.initials: A
authors.lastname: Benko
authors.forename: Maria
authors.initials: M
authors.lastname: Gacser
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Bagdy
mesh_terms: D000328:Adult; D002648:Child; D016241:Child of Impaired Parents / Q000706:statistics & numerical data*; D003863:Depression / Q000453:epidemiology / Q000235:genetics; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D005190:Family; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology / Q000235:genetics*; D010555:Personality Inventory / Q000706:statistics & numerical data; D010641:Phenotype; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D012737:Sex Factors; D011795:Surveys and Questionnaires; D013694:Temperament / Q000145:classification*