title: Dynamic regulation of RNA editing of ion channels and receptors in the mammalian nervous system.
abstract: The post-transcriptional modification of mammalian transcripts in the central nervous system by adenosine-to-inosine RNA editing is an important mechanism for the generation of molecular diversity, and serves to regulate protein function through recoding of genomic information. As the molecular players and an increasing number of edited targets are identified and characterized, adenosine-to-inosine modification serves as an exquisite mechanism for customizing channel function within diverse biological niches. Here, we review the mechanisms that could regulate adenosine-to-inosine RNA editing and the impact of dysregulation in clinical conditions.
authors.affiliation: Department of Physiology, Yong Loo Lin School Medicine, National University of Singapore, 117597, Singapore. g0601821@nus.edu.sg
authors.forename: Bao Zhen
authors.initials: BZ
authors.lastname: Tan
authors.forename: Hua
authors.initials: H
authors.lastname: Huang
authors.forename: Runyi
authors.initials: R
authors.lastname: Lam
authors.forename: Tuck Wah
authors.initials: TW
authors.lastname: Soong
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007473:Ion Channels / Q000235:genetics* / Q000378:metabolism; D008322:Mammals / Q000235:genetics*; D009420:Nervous System / Q000378:metabolism*; D017393:RNA Editing / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism
chemical_list: D007473:Ion Channels; D011956:Receptors, Cell Surface