title: Relationship between urinary iodine and goiter prevalence: results of the Chinese national iodine deficiency disorders survey.
abstract: BACKGROUND
  In 1984, Yu Zhiheng proposed the "U-curve" regularity between urinary iodine (UI) and goiter prevalence (GP). However, along with the adjustment of salt iodine and iodine deficiency disorders (IDD), and surveys followed, some defects were found in the research. As a result, it is time to test and enrich the theory as a series of large sample survey data from China would be helpful.
  
  
  OBJECTIVE
  To test and enrich the theory of "U-curve" relationship between UI and GP.
  
  
  METHODS
  Based on the Chinese national IDD surveys (1999, 2002, 2005), the High Water Iodine survey of 2005, and the High Risk endemias survey of 2007, this article analyzed the relationship between UI and GP. The UI was grouped according to the World Health Organization (WHO) standard, self-defined (5 microg/l), and Yu Zhiheng's level, separately, the GP was calculated for population with different UI level, the tendency curve was drawn and the fitting curve model was estimated by SPSS.
  
  
  RESULTS
  For the 2005 Chinese national survey and 2005 High Water Iodine survey, we finally got the fitting curves and corresponding UI reference limits.
  
  
  CONCLUSIONS
  The UI and GP formed a "U curve" relationship. It varied with some reasons and fell into an accurate U shape step by step. For High Water Iodine endemias survey, the relationship changed to "power curve". Regarding the WHO recommended GP<5%, the UI range of school-age children in normal district should be 110-315 microg/l, whereas, in high water iodine district should be <80 microg/l.
authors.affiliation: Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: P
authors.initials: P
authors.lastname: Liu
authors.forename: S J
authors.initials: SJ
authors.lastname: Liu
authors.forename: X H
authors.initials: XH
authors.lastname: Su
authors.forename: S B
authors.initials: SB
authors.lastname: Zhang
authors.forename: X H
authors.initials: XH
authors.lastname: Ji
mesh_terms: D000293:Adolescent; D002648:Child; D002681:China / Q000453:epidemiology; D006042:Goiter / Q000453:epidemiology* / Q000652:urine; D006801:Humans; D007455:Iodine / Q000172:deficiency / Q000652:urine*; D009749:Nutrition Surveys; D015995:Prevalence
chemical_list: D007455:Iodine