Does the ribosome have initiation and elongation modes of translation?
RNA polymerases differ functionally and structurally in the initiation phase of transcription, when polymerization of 8-12 nucleotides occurs, from the later phases of transcription. Here we argue that the ribosome also might have different properties when translating the first codons in open reading frames, as compared with the later phases of translation.
Tenson
Tanel
T
Institute of Technology, University of Tartu, Nooruse 1, Tartu 50411, Estonia. tanel.tenson@ut.ee
Hauryliuk
Vasili
V
D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D016366:Open Reading Frames; D010441:Peptide Chain Elongation, Translational; D010442:Peptide Chain Initiation, Translational; D012270:Ribosomes / Q000378:metabolism*
D012321:DNA-Directed RNA Polymerases