title: Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats.
abstract: Clinical studies have shown that anxiolytic and antidepressant drug therapy benefits patients with ulcers. Many antidepressant drugs have been shown experimentally to produce antiulcer activity in various ulcer models. This study investigated the antiulcer activities of tianeptine, trazodone, and venlafaxine on indomethacin-induced ulcers in rats; and evaluated tianeptine's effects on oxidant and antioxidant parameters in rat stomach tissue. The results show that trazodone and venlafaxine did not prevent indomethacin-induced ulcers. Tianeptine, however, decreased indomethacin-induced ulcers significantly at all doses used (6, 12, and 25 mg/kg). Famotidine, an H(2) receptor blocker, showed the highest antiulcer activity. Tianeptine significantly prevented the decrease in glutathione (GSH) content that occurred in the indomethacin-only group's damaged stomach tissues. All doses of tianeptine, but especially the 25 mg/kg dose, significantly decreased catalase (CAT) activity in stomach tissue, compared to the control. All doses of tianeptine eliminated the decrease in superoxide dismutase (SOD) activity in the stomach tissue of rats given indomethacin. Although all doses of tianeptine significantly decreased the malondialdehyde (MDA) content, all doses of tianeptine, except 6 mg/kg, decreased myeloperoxidase (MPO) activities significantly compared to the control. Our results indicate that activating enzymatic and non-enzymatic antioxidant mechanisms and inhibiting some toxic oxidant mechanisms play a role in tianeptine's antiulcer effect mechanism.
authors.affiliation: Ataturk University, Faculty of Medicine, Department of Pharmacology, 25240 Erzurum, Turkey. suleyman@atauni.edu.tr
authors.forename: Halis
authors.initials: H
authors.lastname: Suleyman
authors.forename: Elif
authors.initials: E
authors.lastname: Cadirci
authors.forename: Abdulmecit
authors.initials: A
authors.lastname: Albayrak
authors.forename: Beyzagul
authors.initials: B
authors.lastname: Polat
authors.forename: Zekai
authors.initials: Z
authors.lastname: Halici
authors.forename: Feride
authors.initials: F
authors.lastname: Koc
authors.forename: Ahmet
authors.initials: A
authors.lastname: Hacimuftuoglu
authors.forename: Yasin
authors.initials: Y
authors.lastname: Bayir
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000494:pharmacology*; D003511:Cyclohexanols / Q000494:pharmacology; D015738:Famotidine / Q000627:therapeutic use; D007213:Indomethacin / Q000633:toxicity*; D008297:Male; D051381:Rats; D011920:Rats, Inbred WF; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy*; D013841:Thiazepines / Q000494:pharmacology; D014196:Trazodone / Q000494:pharmacology; D000069470:Venlafaxine Hydrochloride
chemical_list: D000897:Anti-Ulcer Agents; D000928:Antidepressive Agents; D003511:Cyclohexanols; D013841:Thiazepines; C050504:tianeptine; D015738:Famotidine; D000069470:Venlafaxine Hydrochloride; D007213:Indomethacin; D014196:Trazodone