title: Resection of the primary tumour or other palliative procedures in incurable stage IV colorectal cancer patients?
abstract: OBJECTIVE
  The aims of the study were to analyse the early and late results of surgical treatment in patients with stage IV colorectal cancer (CRC) and to evaluate the effect of primary tumour resection and other clinical factors on survival.
  
  
  METHODS
  A group of 134 patients with stage IV CRC was electively operated on between 1996 and 2000. The first group underwent resection of the primary tumour (52 patients; mean age 63.4 +/- 10.3) and the second group of patients underwent procedures without resection (82 patients; mean age 62.6 +/- 10.6).
  
  
  RESULTS
  Postoperative morbidity occurred significantly more often (P = 0.041) in the first group--in 26 patients (50%) than in the second group - 19 patients (23.1%). The resection of the primary tumour increased the survival probability; hazard ratio (HR): 1.78; 95% confidence interval (CI): 1.21-2.78%; P = 0.004. Bi-lobar metastases increased mortality risk compared with uni-lobar; HR 2.32; 95% CI: 1.47-3.68; P = 0.0003. The 2-year survival rate in patients with uni-lobar metastases in the first group was 44.2%, in the second group: 30.7%; P = 0.023.
  
  
  CONCLUSIONS
  Primary tumour resection in stage IV CRC increases the risk of postoperative complications. In the given setting, however, it results in an increased 2-year survival rate but it may not influence the 5-year survival rate. In patients with bi-lobar liver metastases resection of the primary tumour does not prolong survival time.
authors.affiliation: Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Plac Hallera, Poland. m.mik@wp.pl
authors.forename: M
authors.initials: M
authors.lastname: Mik
authors.forename: L
authors.initials: L
authors.lastname: Dziki
authors.forename: P
authors.initials: P
authors.lastname: Galbfach
authors.forename: R
authors.initials: R
authors.lastname: Trzcinski
authors.forename: A
authors.initials: A
authors.lastname: Sygut
authors.forename: A
authors.initials: A
authors.lastname: Dziki
mesh_terms: D000368:Aged; D003082:Colectomy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010166:Palliative Care / Q000379:methods*; D011044:Poland / Q000453:epidemiology; D011184:Postoperative Period; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends