title: GIGYF2 mutations are not a frequent cause of familial Parkinson's disease.
abstract: Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD.
authors.affiliation: Department of Clinical Genetics, Erasmus MC, 3000 CA Rotterdam, The Netherlands.
authors.forename: Alessio
authors.initials: A
authors.lastname: Di Fonzo
authors.forename: Edito
authors.initials: E
authors.lastname: Fabrizio
authors.forename: Astrid
authors.initials: A
authors.lastname: Thomas
authors.forename: Emiliana
authors.initials: E
authors.lastname: Fincati
authors.forename: Roberto
authors.initials: R
authors.lastname: Marconi
authors.forename: Michele
authors.initials: M
authors.lastname: Tinazzi
authors.forename: Guido J
authors.initials: GJ
authors.lastname: Breedveld
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Simons
authors.forename: Hsin F
authors.initials: HF
authors.lastname: Chien
authors.forename: Joaquim J
authors.initials: JJ
authors.lastname: Ferreira
authors.forename: Martin W
authors.initials: MW
authors.lastname: Horstink
authors.forename: Giovanni
authors.initials: G
authors.lastname: Abbruzzese
authors.forename: Barbara
authors.initials: B
authors.lastname: Borroni
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cossu
authors.forename: Alessio
authors.initials: A
authors.lastname: Dalla Libera
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fabbrini
authors.forename: Marco
authors.initials: M
authors.lastname: Guidi
authors.forename: Michele
authors.initials: M
authors.lastname: De Mari
authors.forename: Leonardo
authors.initials: L
authors.lastname: Lopiano
authors.forename: Emilia
authors.initials: E
authors.lastname: Martignoni
authors.forename: Paolo
authors.initials: P
authors.lastname: Marini
authors.forename: Marco
authors.initials: M
authors.lastname: Onofrj
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Stocchi
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Toni
authors.forename: Cristina
authors.initials: C
authors.lastname: Sampaio
authors.forename: Egberto R
authors.initials: ER
authors.lastname: Barbosa
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Meco
authors.forename: Ben A
authors.initials: BA
authors.lastname: Oostra
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bonifati
mesh_terms: D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics*; D010375:Pedigree
chemical_list: D002352:Carrier Proteins; C478016:GIGYF2 protein, human