title: Treatment-resistant meningitis leading to the diagnosis of Currarino syndrome: a case report.
abstract: A 20-day-old female infant developed fever. Sepsis evaluation revealed cerebrospinal fluid (CSF) pleocytosis and a modestly decreased CSF glucose. After 48 hours of broad-spectrum antibiotics, the infant remained febrile. Repeat CSF analysis showed increased pleocytosis and a very low glucose value. Subsequently, a rectothecal fistula and sacral abnormalities were found, leading to the diagnosis of Currarino syndrome. Parameningeal foci should be considered in treatment-resistant meningitis.
authors.affiliation: Mayo School of Graduate Medical Education, Rochester, MN, USA. kiefer.autumn@mayo.edu
authors.forename: Autumn S
authors.initials: AS
authors.lastname: Kiefer
authors.forename: Priyanka
authors.initials: P
authors.lastname: Gupta
authors.forename: Salman
authors.initials: S
authors.lastname: Kirmani
authors.forename: Kara
authors.initials: K
authors.lastname: Schwartz
authors.forename: Nancy
authors.initials: N
authors.lastname: Henry
authors.forename: Philip R
authors.initials: PR
authors.lastname: Fischer
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis*; D001003:Anal Canal / Q000002:abnormalities; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D003251:Constriction, Pathologic; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy*; D008588:Meningocele; D012003:Rectal Fistula; D012447:Sacrum / Q000002:abnormalities; D013577:Syndrome; D014157:Transcription Factors / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D018398:Homeodomain Proteins; C490003:MNX1 protein, human; D014157:Transcription Factors