title: Inflammatory epidermolysis bullosa acquisita: case report.
abstract: We report a case of an inflammatory variant of epidermolysis bullosa acquisita in a 53-year-old male, with itching blistering eruption on the trunk, armpits and limbs for six months. The skin biopsy specimen showed subepidermal blister with neutrophils. Direct immunofluorescence revealed linear depositions of IgG, IgA, IgM and C3 at the basement membrane; indirect immunofluorescence and salt Split Skin were negative. Antinuclear antibodies were also negative. Improvement of the blisters followed treatment with systemic corticotherapy and some lesions healed with milia. This is a rare presentation of epidermolysis bullosa acquisita, with inflammatory lesions at first.
authors.affiliation: Complexo Hospitalar Padre Bento de Guarulhos - Guarulhos (SP), Brasil. dermato.dambrosio@gmail.com
authors.forename: Marcelo D'Ambrosio
authors.initials: MD
authors.lastname: Fernandes
authors.forename: Mariana Discacciati
authors.initials: MD
authors.lastname: Chiminazzo
authors.forename: Antonio José
authors.initials: AJ
authors.lastname: Tebcherani
authors.forename: Valéria
authors.initials: V
authors.lastname: Aoki
authors.forename: Ana Paula Galli
authors.initials: AP
authors.lastname: Sanchez
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D016107:Epidermolysis Bullosa Acquisita / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology*
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone