title: Dedicated mouse production and husbandry.
abstract: The complexity of mammalian biology, in combination with the ability to manipulate the embryonic genome in mice, has provided specific challenges in terms of mouse breeding, analysis, and husbandry. From the initial planning stage of a project involving the generation of novel, genetically altered mice, it is important to consider a number of potential issues involving the successful establishment and propagation of a transgenic line.
authors.affiliation: Medical Research Council, Harwell, UK.
authors.forename: Lucie
authors.initials: L
authors.lastname: Vizor
authors.forename: Sara
authors.initials: S
authors.lastname: Wells
mesh_terms: D000822:Animal Husbandry / Q000379:methods* / Q000592:standards; D000818:Animals; D004195:Disease Models, Animal; D004622:Embryo, Mammalian / Q000166:cytology / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic