title: Response analysis of non-hodgkin lymphoma using magnetic resonance imaging-based volumes.
abstract: OBJECTIVE
  The aim of this study was to determine the volume of non-Hodgkin lymphomas (NHLs) using semiautomatic segmentation and to correlate these results with clinical findings, treatment, and prognosis in patients with B-cell-type NHL.
  
  
  METHODS
  For this study, 29 patients with NHL underwent magnetic resonance imaging at 5 time points after onset of disease. Volumetric analysis of the tumors was accomplished with semiautomatic segmentation by the Anatomatic software.
  
  
  RESULTS
  The median tumor volumes from the first to the fifth examination were 468, 256, 90, 38, and 33 cm. Good correlation with 1-dimensional and 2-dimensional measures, used as standard methods in response categorization, was found. Surprisingly, volume reductions in excess of 239 cm after only 1 week of chemotherapy decreased the survival probability.
  
  
  CONCLUSIONS
  Volume measurements seem to be highly informative for prognosis in the very early stages of treatment for patients with NHL.
authors.affiliation: Regional Medical Imaging Centre, Department of Radiology, Tampere University Hospital, Tampere, Finland. maija.rossi@pshp.fi
authors.forename: Maija
authors.initials: M
authors.lastname: Rossi
authors.forename: Prasun
authors.initials: P
authors.lastname: Dastidar
authors.forename: Hannu
authors.initials: H
authors.lastname: Pertovaara
authors.forename: Ritva
authors.initials: R
authors.lastname: Järvenpää
authors.forename: Tiina
authors.initials: T
authors.lastname: Luukkaala
authors.forename: Pirkko-Liisa
authors.initials: PL
authors.lastname: Kellokumpu-Lehtinen
authors.forename: Sylvia
authors.initials: S
authors.lastname: Rautakunnas
authors.forename: Tomi
authors.initials: T
authors.lastname: Heinonen
authors.forename: Seppo
authors.initials: S
authors.lastname: Soimakallio
authors.forename: Hannu
authors.initials: H
authors.lastname: Eskola
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000628:therapy*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents