Antiviral evaluation of N-amino-1,2,3-triazoles against Cantagalo virus replication in cell culture.
This paper describes the antiviral evaluation of new N-amino-1,2,3-triazole derivatives, 1-(substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid ethyl esters, 3 and 1-(4-substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazides, 4, on Cantagalo virus replication. 1-(4-Fluoro-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazide, 4e, exhibited a significant antiviral effect. Characterization of all compounds was confirmed by IR, (1)H and (13)C spectroscopies and elemental analysis. In addition, molecular structure of 4e was also reported.
Jordão
Alessandro K
AK
Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Quiímica, Outeiro de São João Baptista, 24020-141 Niterói, RJ, Brazil.
Afonso
Priscila P
PP
Ferreira
Vitor F
VF
de Souza
Maria C B V
MC
Almeida
Maria C B
MC
Beltrame
Cristiana O
CO
Paiva
Daniel P
DP
Wardell
Solange M S V
SM
Wardell
James L
JL
Tiekink
Edward R T
ER
Damaso
Clarissa R
CR
Cunha
Anna C
AC
D000640:Amitrole / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014616:Vaccinia virus / Q000187:drug effects*; D014764:Viral Proteins / Q000032:analysis / Q000378:metabolism
D000998:Antiviral Agents; D014764:Viral Proteins; D000640:Amitrole