Interleukin 17 production among patients with American cutaneous leishmaniasis.
Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r2 = 0.86; P<.001) These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.
Bacellar
Olívia
O
Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador-Bahia, Brazil.
Faria
Daniela
D
Nascimento
Márcia
M
Cardoso
Thiago M
TM
Gollob
Kenneth J
KJ
Dutra
Walderez O
WO
Scott
Phillip
P
Carvalho
Edgar M
EM
D015551:Autoimmunity; D006801:Humans; D007249:Inflammation / Q000276:immunology; D020381:Interleukin-17 / Q000235:genetics*; D007897:Leishmaniasis, Mucocutaneous / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D012016:Reference Values; D018417:Th1 Cells / Q000276:immunology
D020381:Interleukin-17