Up-regulation of microRNA in bladder tumor tissue is not common.
MicroRNAs (miRNAs) have recently been shown to down-regulate gene expression by targeting mRNA translation and to play a critical role in tumorigenesis; how they regulate bladder tumor development, particularly in patients, is, however, poorly understood. The difference in miRNA expression in a bladder tumor compared with healthy tissue from the same patients was examined using microRNA arrays in seven patients. Here, we showed that up-regulation of miRNA was not commonly found in this limited number of patients, and four miRNAs (miR-26a, miR-29c, miR-30c, miR-30e-5p) were down-regulated as a common marker in patients with a 1-3 grade of disease. Our data suggest that instead of up-regulation of carcinogenic miRNAs, loss of regulation of these miRNA may be critical for bladder tumor development in patients.
Wang
Gang
G
Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Jie Fang Road, Hangzhou, Zhejiang, People's Republic of China. gwang59@gmail.com
Zhang
Honghe
H
He
Huadong
H
Tong
Wenjuan
W
Wang
Bin
B
Liao
Guodong
G
Chen
Zhaodian
Z
Du
Caigan
C
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D008875:Middle Aged; D015854:Up-Regulation; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D035683:MicroRNAs