title: Epigenetics and leukemia: unraveling oncogenic processes in the BLV ovine model.
abstract: Bovine Leukemia Virus (BLV)-induced B-cell leukemia in sheep is a valuable large animal model for investigating oncogenic mechanisms, particularly those associated with human T-cell leukemia virus 1 (HTLV-1). Multiple factors including viral genes, genetic and epigenetic alterations, and the host immune system are likely to contribute and cooperate in the leukemogenesis of adult T-cell leukemia (ATL) in human and B-cell leukemia in sheep. While considerable effort has been made to explore the role of viral determinants in the transformation process, the participation of host-related mechanisms has been poorly addressed. We discuss recent evidence from sheep studies in the context of the growing knowledge that has accumulated in the field of epigenetics in human cancer. These results support the hypothesis that epigenetic events, which were initially identified as a causative mechanism of virus silencing, are also major players in host gene regulation. Future studies in sheep will increase the number of genes identified that are aberrantly regulated by epigenetic processes and identify potential biomarkers which may be used as therapeutic targets in leukemia.
authors.affiliation: Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles (ULB), 121 Boulevard de Waterloo, 1000 Brussels, Belgium.
authors.forename: Makram
authors.initials: M
authors.lastname: Merimi
authors.forename: Yurda
authors.initials: Y
authors.lastname: Ozkan
authors.forename: Yvette
authors.initials: Y
authors.lastname: Cleuter
authors.forename: Philip
authors.initials: P
authors.lastname: Griebel
authors.forename: Arsene
authors.initials: A
authors.lastname: Burny
authors.forename: Philippe
authors.initials: P
authors.lastname: Martiat
authors.forename: Anne
authors.initials: A
authors.lastname: Van den Broeke
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D020868:Gene Silencing; D005814:Genes, Viral; D007938:Leukemia / Q000821:virology*; D001909:Leukemia Virus, Bovine / Q000235:genetics / Q000472:pathogenicity*; D009857:Oncogenes; D012756:Sheep