Therapeutic effect of phytoecdysteroids rich extract from Ajuga iva on alloxan induced diabetic rats liver, kidney and pancreas.
In the current study, the effect of Ajuga iva extract on blood glucose, lipid profile, hepatic and renal toxicity and antioxidant enzyme activities in alloxan-induced diabetic rats was investigated. Diabetes was confirmed by measuring the glucoserua concentration 15 days after alloxan administration. Ajuga iva extract was administrated orally 3 weeks after alloxan injection. Our results investigate that Ajuga iva extract supplementation increased the levels of both enzymatic antioxidant (superoxide dismutase, catalase and glutathione peroxidase) and metals antioxidants (iron, copper, magnesium, calcium) and decreased lipid peroxidation level (TBARs). Besides Ajuga iva ameliorated diabetes provoked hepatic and renal toxicity appeared by a lower level in total and direct bilirubin, urea, creatinine, triglyceride (TG), cholesterol and a higher level in HDL-cholesterol. Besides, the activities of phosphatase alkalines (PAL), aspartate and lactate transaminase (AST & ALT) were decreased. The benefices effects of phytoecdysteroids of Ajuga iva confirmed by histological observation in pancreatic tissues. In conclusion, Ajuga iva phytoecdysteroids supplements seem to be beneficial for correcting the hyperglycemia and preventing diabetic complications in liver, pancreas and kidneys.
Hamden
Khaled
K
Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia. khalid.hamden@gmail.com
Ayadi
Fatma
F
Jamoussi
Kamel
K
Masmoudi
Hatem
H
Elfeki
Abdelfattah
A
D031328:Ajuga / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D026461:Ecdysteroids / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects*; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D026461:Ecdysteroids; D008055:Lipids; D010936:Plant Extracts; D014508:Urea; D003404:Creatinine