Specific therapeutic schemes of omeprazole affect the orientation of Helicobacter pylori.
Until now, it has been unclear how proton pump inhibitors (PPIs) support Helicobacter pylori therapy. We tested whether the PPI omeprazole acts on the spatial orientation of H. pylori in the gastric mucus of infected Mongolian gerbils. Following repetitive PPI administration once daily but not following single doses or administration every 8 h, the bacterial spatial distribution changed, indicating a loss of orientation. Therefore, the therapeutic scheme of PPI administration may affect efficiency of treatment.
Azevedo-Vethacke
Marina
M
Institut für Physiologie, Ruhr-Universität Bochum, Im Lottental 36, 44801 Bochum, Germany.
Garten
Désirée
D
Groll
Claudia
C
Schreiber
Sören
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000187:drug effects / Q000382:microbiology; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000472:pathogenicity; D009853:Omeprazole / Q000494:pharmacology* / Q000627:therapeutic use*; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D009853:Omeprazole