Antiplasmodial and other constituents from four Indonesian Garcinia spp.
Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L., Garcinia cornea L. and Garcinia cymosa K. Schum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, beta-sitosterol-3-O-beta-D-glucoside and stigmasterol-3-O-beta-D-glucoside from the stem bark of G. griffithii; friedelin and 3beta-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (+/-)-morelloflavone, morelloflavone-7-O-beta-D-glucoside or fukugiside, the triterpene 3beta-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene beta-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity.
Elfita
Elfita
E
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University, Palembang, Indonesia.
Muharni
Muharni
M
Latief
Madyawati
M
Darwati
Darwati
D
Widiyantoro
Ari
A
Supriyatna
Supriyatna
S
Bahti
Husein H
HH
Dachriyanus
Dachriyanus
D
Cos
Paul
P
Maes
Louis
L
Foubert
Kenne
K
Apers
Sandra
S
Pieters
Luc
L
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification; D029760:Garcinia / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007214:Indonesia; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013265:Stigmasterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C541852:1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone; D000962:Antimalarials; D000981:Antiprotozoal Agents; D001577:Benzophenones; D047309:Flavones; D005960:Glucosides; D012855:Sitosterols; D014315:Triterpenes; D044004:Xanthones; C541853:garcihombronane D; C515918:isoxanthochymol; C464587:stigmasterol glucoside; D007810:Lanosterol; D002392:Catechin; D013265:Stigmasterol; C011015:lyoniside