title: CPEB3 is associated with human episodic memory.
abstract: Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans, the ribozyme sequence is polymorphic and harbors a single nucleotide polymorphism that influences cleavage activity of the ribozyme. Here we show that this variation is related to performance in an episodic memory task and that the effect of the variation depends on the emotional valence of the presented material. Our data suggest a role for human CPEB3 in human episodic memory.
authors.affiliation: Division of Molecular Psychology, University of Basel Basel, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Vogler
authors.forename: Klara
authors.initials: K
authors.lastname: Spalek
authors.forename: Amanda
authors.initials: A
authors.lastname: Aerni
authors.forename: Philippe
authors.initials: P
authors.lastname: Demougin
authors.forename: Ariane
authors.initials: A
authors.lastname: Müller
authors.forename: Kim-Dung
authors.initials: KD
authors.lastname: Huynh
authors.forename: Andreas
authors.initials: A
authors.lastname: Papassotiropoulos
authors.forename: Dominique J-F
authors.initials: DJ
authors.lastname: de Quervain