The CUL4 enigma: culling DNA repair factors.
Although CUL4-containing ubiquitin ligases regulate DNA repair and DNA damage checkpoints, Liu et al. (2009) report in this issue of Molecular Cell that Cul4a-deficient mice exhibit surprising resistance to ultraviolet-induced skin tumors, providing insight into how ubiquitination regulates genome integrity.
Sugasawa
Kaoru
K
Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, Kobe, Hyogo, Japan. ksugasawa@garnet.kobe-u.ac.jp
D000818:Animals; D044842:Cullin Proteins / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D046911:Macromolecular Substances; D051379:Mice; D025801:Ubiquitin / Q000378:metabolism
C491940:Cul4a protein, mouse; D044842:Cullin Proteins; D046911:Macromolecular Substances; D025801:Ubiquitin