Neurodegenerative disease: Diabetes, microvascular pathology and Alzheimer disease.
Epidemiological studies suggest that the risk of developing cognitive impairment and dementia is increased in individuals with diabetes mellitus, although the evidence from clinicopathological studies on neurodegenerative changes is at odds with these observations. A thorough appraisal of concomitant vascular changes in dementia might resolve this incongruity.
Kalaria
Raj N
RN
Institute for Ageing and Health, Wolfson Research Center (Neuropathology),Newcastle General Hospital, Westgate Road,Newcastle upon Tyne, UK. r.n.kalaria@ncl.ac.uk
D000544:Alzheimer Disease / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications*; D003072:Cognition Disorders / Q000209:etiology; D003920:Diabetes Mellitus / Q000473:pathology*; D006801:Humans; D055806:Microvessels / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000150:complications / Q000473:pathology*; D012307:Risk Factors
D016229:Amyloid beta-Peptides