The V109G polymorphism in the p27 gene is associated with endometriosis.
OBJECTIVE
To investigate the prevalence of the p27 gene polymorphism in women with endometriosis.


METHODS
Transversal case-control study. Genomic DNA was extracted from cells collected from buccal swabs. The p27 V109G polymorphism was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a hospital-based Brazilian population.


RESULTS
We analysed the 104 patients and 109 control subjects. The distribution of genotype and allele frequencies of p27 V109G polymorphism was significantly different between the endometriosis cases and healthy women (p=0.016 and 0.002). Women who had at least one mutated allele presented twofold chances for endometriosis development (OR=1.9; 95% CI, 1.120-3.343).


CONCLUSIONS
The polymorphic variant at codon 109 of the p27 gene seems to be associated with higher risk of endometriosis development.
Camargo-Kosugi
Cíntia M
CM
Federal University of São Paulo, Escola Paulista de Medicina, Gynecology Department, Sao Paulo, SP, Brazil.
da Silva
Ismael D C G
ID
Sato
Hélio
H
D'Amora
Paulo
P
Carvalho
Cristina V
CV
Nogueira-de-Souza
Naiara C
NC
Girão
Manoel J C B
MJ
Schor
Eduardo
E
D000328:Adult; D016022:Case-Control Studies; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D050760:Cyclin-Dependent Kinase Inhibitor p27