MHC class I antigen presentation: learning from viral evasion strategies.
The cell surface display of peptides by MHC class I molecules to lymphocytes provides the host with an important surveillance mechanism to protect against invading pathogens. However, in turn, viruses have evolved elegant strategies to inhibit various stages of the MHC class I antigen presentation pathway and prevent the display of viral peptides. This Review highlights how the elucidation of mechanisms of viral immune evasion is important for advancing our understanding of virus-host interactions and can further our knowledge of the MHC class I presentation pathway as well as other cellular pathways.
Hansen
Ted H
TH
Washington University School of Medicine, Department of Pathology and Immunology, St Louis, Missouri 63110, USA.
Bouvier
Marlene
M
D018528:ATP-Binding Cassette Transporters / Q000276:immunology / Q000378:metabolism; D000818:Animals; D017951:Antigen Presentation; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000821:virology; D004791:Enzyme Inhibitors / Q000276:immunology / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D026901:Membrane Transport Proteins / Q000276:immunology / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000821:virology; D025801:Ubiquitin / Q000276:immunology / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000276:immunology / Q000378:metabolism; D014764:Viral Proteins / Q000276:immunology* / Q000378:metabolism; D014780:Viruses / Q000276:immunology*
D018528:ATP-Binding Cassette Transporters; D004791:Enzyme Inhibitors; D015395:Histocompatibility Antigens Class I; D026901:Membrane Transport Proteins; D025801:Ubiquitin; D014764:Viral Proteins; C107762:tapasin; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex