title: Homo-D-lactic acid fermentation from arabinose by redirection of the phosphoketolase pathway to the pentose phosphate pathway in L-lactate dehydrogenase gene-deficient Lactobacillus plantarum.
abstract: Optically pure d-lactic acid fermentation from arabinose was achieved by using the Lactobacillus plantarum NCIMB 8826 strain whose l-lactate dehydrogenase gene was deficient and whose phosphoketolase gene was substituted with a heterologous transketolase gene. After 27 h of fermentation, 38.6 g/liter of d-lactic acid was produced from 50 g/liter of arabinose.
authors.affiliation: Department of Chemical Science and Engineering, Kobe University, Rokkodaicho, Nada-ku, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Okano
authors.forename: Shogo
authors.initials: S
authors.lastname: Yoshida
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tanaka
authors.forename: Chiaki
authors.initials: C
authors.lastname: Ogino
authors.forename: Hideki
authors.initials: H
authors.lastname: Fukuda
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kondo
mesh_terms: D000446:Aldehyde-Lyases / Q000378:metabolism; D001089:Arabinose / Q000378:metabolism*; D005285:Fermentation; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000172:deficiency; D019344:Lactic Acid / Q000378:metabolism*; D048191:Lactiplantibacillus plantarum / Q000235:genetics* / Q000378:metabolism*; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008954:Models, Biological; D010427:Pentose Phosphate Pathway / Q000235:genetics
chemical_list: D019344:Lactic Acid; D001089:Arabinose; D007770:L-Lactate Dehydrogenase; D000446:Aldehyde-Lyases; C022367:phosphoketolase