Effect of xenotransplantation of cell cultures enriched with stem and progenitor cells on hormonal profile of rats with abdominal cryptorchism.
We present the results of application of cell cultures enriched with stem and progenitor cells for the treatment of experimental abdominal cryptorchism in outbred albino rats. Xenotransplantation of human fetal enriched cell cultures was performed to animals with experimental cryptorchism during orchiolysis. Total testosterone, luteinizing and follicle-stimulating hormones were assayed by immunochemiluminescent method. It was found that xenotransplantation of cell cultures enriched with stem and progenitor cells normalized the level of total testosterone, decreased the concentrations of gonadotropic hormones, reduced hyperplasia of Leydig cells and the number of chromaffin granules, and restored normochromism of Leydig cells nuclei.
Sukhikh
G T
GT
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Federal Agency of Medical Technologies, Russia.
Kamalov
A A
AA
Poltavtseva
R A
RA
Zaraiskii
E I
EI
Plotnikov
E Yu
EY
Kirpatovskii
V I
VI
Efremov
E A
EA
Orlova
E V
EV
Pavlova
G V
GV
Okhobotov
D A
DA
D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D002478:Cells, Cultured; D003456:Cryptorchidism / Q000378:metabolism* / Q000628:therapy*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D051381:Rats; D013234:Stem Cells / Q000166:cytology*; D013739:Testosterone / Q000378:metabolism; D014183:Transplantation, Heterologous / Q000379:methods*
D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone