Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain.
Diffuse optical correlation methods were adapted for three-dimensional (3D) tomography of cerebral blood flow (CBF) in small animal models. The image reconstruction was optimized using a noise model for diffuse correlation tomography which enabled better data selection and regularization. The tomographic approach was demonstrated with simulated data and during in-vivo cortical spreading depression (CSD) in rat brain. Three-dimensional images of CBF were obtained through intact skull in tissues(~4mm) deep below the cortex.
Zhou
Chao
C
Yu
Guoqiang
G
Furuya
Daisuke
D
Greenberg
Joel
J
Yodh
Arjun
A
Durduran
Turgut
T