title: Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility study.
abstract: The purpose of this study was to determine the feasibility of an acupuncture clinical trial to prevent radiation therapy (RT)-induced fatigue. We conducted a cross-sectional survey study and a single-arm acupuncture clinical trial among patients undergoing RT. Patients with a Karnofsky score of less than 60, severe anemia, or substantial psychological diagnoses were excluded. Patients received up to 12 treatments of acupuncture over the entire course of their RT. The Lee Fatigue Scale (LFS) was administered at baseline, in the middle of RT, and at the end of RT, along with the Patient Global Impression of Change (PGIC). Among the 48 of 53 (91% response rate) survey participants, 20 (42%) reported that they would participate if the study were available, 13 (27%) would not participate, and 15 (31%) were unsure. Among the 16 trial participants, average fatigue and energy domains of the LFS remained stable during and after RT, without any expected statistical decline owing to RT. Based on the PGIC at the end of RT, 2 subjects (13%) reported their fatigue as worse, 8 (50%) as stable, and 6 (37%) as better. Acupuncture has the potential to prevent RT-related fatigue, which will need to be confirmed by conducting a randomized controlled trial.
authors.affiliation: Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA. jun.mao@uphs.upenn.edu
authors.forename: Jun James
authors.initials: JJ
authors.lastname: Mao
authors.forename: Terry
authors.initials: T
authors.lastname: Styles
authors.forename: Andrea
authors.initials: A
authors.lastname: Cheville
authors.forename: James
authors.initials: J
authors.lastname: Wolf
authors.forename: Shawn
authors.initials: S
authors.lastname: Fernandes
authors.forename: John T
authors.initials: JT
authors.lastname: Farrar
mesh_terms: D015670:Acupuncture Therapy; D003430:Cross-Sectional Studies; D005221:Fatigue / Q000517:prevention & control*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects*