title: Role of Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma.
abstract: There are recent reports of effective treatment of cutaneous hemangiomas with Propranolol. The current study aims to assess efficacy of systemic Propranolol for subglottic hemangiomas and to discuss its place among the other available therapies. We report 2 infants with subglottic hemangiomas, which were resistant to other established medical treatments. One infant presented with PHACES association, the other with widespread cutaneous congenital hemangiomas. Both were subsequently treated with systemic Propranolol. Both patients' subglottic hemangiomas responded dramatically to systemic Propranolol. No side effects of the therapy occurred, and a safety protocol previously designed for Propranolol prescribed for other indications was applied to our patients. Propranolol appears to be an effective treatment for subglottic hemangiomas and should now be used as a first-line treatment in subglottic hemangiomas when intervention is required.
authors.affiliation: Armand-Trousseau Children Hospital, Pediatric ENT Department, AP-HP, 75012 Paris, France. f.denoyelle@trs.aphp.fr
authors.forename: Françoise
authors.initials: F
authors.lastname: Denoyelle
authors.forename: Nicolas
authors.initials: N
authors.lastname: Leboulanger
authors.forename: Odile
authors.initials: O
authors.lastname: Enjolras
authors.forename: Robert
authors.initials: R
authors.lastname: Harris
authors.forename: Gilles
authors.initials: G
authors.lastname: Roger
authors.forename: Eréa-Noël
authors.initials: EN
authors.lastname: Garabedian
mesh_terms: D000015:Abnormalities, Multiple; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006391:Hemangioma / Q000151:congenital / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007822:Laryngeal Neoplasms / Q000151:congenital / Q000188:drug therapy*; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D012878:Skin Neoplasms; D014134:Tracheal Neoplasms / Q000151:congenital / Q000188:drug therapy*
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol