title: Detection of a novel HLA-B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence-based typing: curiosity rewarded.
abstract: We report here a novel HLA-B allele, B*2740, discovered in Taiwanese volunteer marrow donors. The new sequence has nucleotide variation at position 527 (T-->A) as compared to B*2708. The nucleotide change caused an amino acid substitution from valine (V) to glutamic acid (E) at codon 152. Since B*2740 carries sequence confers to HLA-Bw6 public epitope we believe that this novel B*27 allele might have been generated from a gene conversion involving a Bw4-specific allele (probably B*2704) and a Bw6-specific allele.
authors.affiliation: Laboratory of Immunogenetics and Cord Blood Bank, Buddhist Tzu Chi Marrow Donor Registry and Stem Cells Centre, Buddhist Tzu Chi General Hospital, Buddhist Compassion Relief Tzu Chi Foundation, 707 Section 3 Chung Yang Road, Hualien, Taiwan.
authors.forename: M J
authors.initials: MJ
authors.lastname: Chen
authors.forename: T C
authors.initials: TC
authors.lastname: Yang
authors.forename: C C
authors.initials: CC
authors.lastname: Chu
authors.forename: M H
authors.initials: MH
authors.lastname: Shyr
authors.forename: C L
authors.initials: CL
authors.lastname: Lin
authors.forename: P Y
authors.initials: PY
authors.lastname: Lin
authors.forename: K L
authors.initials: KL
authors.lastname: Yang
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence; D001853:Bone Marrow / Q000378:metabolism; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005091:Exons / Q000235:genetics; D005785:Gene Conversion / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D018698:Glutamic Acid / Q000235:genetics; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D019520:Living Donors; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013624:Taiwan; D014633:Valine / Q000235:genetics
chemical_list: D015796:HLA-B27 Antigen; D018698:Glutamic Acid; D014633:Valine