title: Relationship of retinal vascular caliber with optic disc and macular structure.
abstract: OBJECTIVE
  To examine the relationships of retinal vascular caliber with optic disc, macular, and retinal nerve fiber layer (RNFL) characteristics as measured with optical coherence tomography (OCT).
  
  
  METHODS
  Observational cross-sectional study.
  
  
  METHODS
  This study included a subset of healthy children enrolled in the Singapore Cohort Study of the Risk Factors of Myopia (SCORM). Optic disc, macular, and RNFL morphology were measured with Stratus OCT 3. Digital retinal photography was performed and retinal arteriolar and venular caliber measured using validated imaging software.
  
  
  RESULTS
  One hundred and four children (mean age 11.51 +/- 0.52 years; 50% male) were included. In multivariate analyses, smaller horizontal integrated rim width and rim area were associated with narrower retinal arterioles and venules (all P < .05), and shorter horizontal rim length was associated with narrower venules (P = .04). Optic disc diameter was not associated with arteriolar or venular caliber. Larger vertical cup-to-disc ratios and cup-to-disc-area ratios were associated with narrower venules but not arterioles (P = .01 and P = .003, respectively). A thinner average RNFL measurement was associated with narrower arterioles and venules, and smaller total macular volume was associated with narrower venules.
  
  
  CONCLUSIONS
  Thinner optic disc rims and RNFL measurements were associated with narrower retinal arterioles and venules, and larger cup-to-disc ratios with narrower venules. These findings suggest that retinal vessel caliber varies systematically with morphologic differences in the optic nerve head, retina, and macula.
authors.affiliation: Singapore National Eye Centre, Singapore.
authors.forename: Laurence S
authors.initials: LS
authors.lastname: Lim
authors.forename: Seang Mei
authors.initials: SM
authors.lastname: Saw
authors.forename: Ning
authors.initials: N
authors.lastname: Cheung
authors.forename: Paul
authors.initials: P
authors.lastname: Mitchell
authors.forename: Tien Y
authors.initials: TY
authors.lastname: Wong
mesh_terms: D044466:Asian People / Q000208:ethnology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009412:Nerve Fibers; D009898:Optic Disk / Q000033:anatomy & histology*; D010781:Photography; D012016:Reference Values; D012029:Refraction, Ocular / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000166:cytology*; D012171:Retinal Vessels / Q000033:anatomy & histology*; D012846:Singapore; D041623:Tomography, Optical Coherence