Lipins, lipids and nuclear envelope structure.
The lipid composition of biological membranes is crucial for many aspects of organelle function, including growth, signalling, and transport. Lipins represent a novel family of lipid phosphatases that dephosphorylate phosphatidic acid (PA) to produce diacylglycerol (DAG), and perform key functions in phospholipid and triacylglycerol biosynthesis and gene expression. In addition to its role in lipid biosynthesis, the yeast lipin Pah1p and its regulators are required for the maintenance of a spherical nuclear shape. This review summarizes recent advances in our understanding of the yeast lipin Pah1p and highlights the possible roles of phospholipid metabolism in nuclear membrane biogenesis.
Siniossoglou
Symeon
S
Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, CB2 0XY, UK. ss560@cam.ac.uk
D000818:Animals; D050356:Lipid Metabolism; D008563:Membrane Lipids / Q000096:biosynthesis* / Q000378:metabolism; D009685:Nuclear Envelope / Q000378:metabolism* / Q000648:ultrastructure*; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000378:metabolism; D010711:Phosphatidate Phosphatase / Q000096:biosynthesis* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000096:biosynthesis* / Q000378:metabolism
D008563:Membrane Lipids; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; C079831:PAH1 protein, S cerevisiae; D010711:Phosphatidate Phosphatase