Cardiovascular and metabolic complications during androgen deprivation: exercise as a potential countermeasure.
Apart from the well-established adverse musculoskeletal and sexual health effects of androgen deprivation therapy (ADT), evidence is accumulating of substantial ADT-related cardiovascular and metabolic complications, which may impact quality of life and overall survival. In this brief review we discuss (1) the incidence of cardiovascular and metabolic complications during/following ADT from large cohort studies, (2) the increased risk factors for cardiovascular and metabolic disease from cross-sectional and prospective studies and (3) the use of physical exercise as a countermeasure in this new era of ADT-related toxicity. It is clear that exercise has the potential to provide a myriad of benefits to men undergoing ADT that may result in reduced morbidity and mortality, and subsequently improve quality of life.
Galvão
D A
DA
Vario Health Institute, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. d.galvao@ecu.edu.au
Taaffe
D R
DR
Spry
N
N
Joseph
D
D
Newton
R U
RU
D000726:Androgen Antagonists / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000209:etiology; D015444:Exercise; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012307:Risk Factors
D000726:Androgen Antagonists