title: A rare case of renal cell carcinoma metastasizing to the uterine cervix.
abstract: Metastatic tumors to the uterine cervix originating from malignancies in other organs are very rare. A case of a 45-year-old white woman presenting with vaginal bleeding, due to renal cell carcinoma metastasizing to the cervix, is reported. The patient had been treated four years and five months earlier due to two primary malignancies: colon adenocarcinoma and renal cell carcinoma. After D&C, microscopic examination and immunohistochemical staining showed that the tumor was metastatic, originating from the renal cell carcinoma. Radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymph node resection followed, and postoperatively the patient received targeted therapy with sutinib malate. The possibility of metastasis from another primary should be considered in the differential diagnosis of tumors of the uterine cervix in order to plan optimal management.
authors.affiliation: Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece. mzafrakas@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Zafrakas
authors.forename: A N
authors.initials: AN
authors.lastname: Papanikolaou
authors.forename: I D
authors.initials: ID
authors.lastname: Venizelos
authors.forename: D
authors.initials: D
authors.lastname: Kellartzis
authors.forename: T
authors.initials: T
authors.lastname: Agorastos
authors.forename: J N
authors.initials: JN
authors.lastname: Bontis
mesh_terms: D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy