title: Up-regulation of microRNA in bladder tumor tissue is not common.
abstract: MicroRNAs (miRNAs) have recently been shown to down-regulate gene expression by targeting mRNA translation and to play a critical role in tumorigenesis; how they regulate bladder tumor development, particularly in patients, is, however, poorly understood. The difference in miRNA expression in a bladder tumor compared with healthy tissue from the same patients was examined using microRNA arrays in seven patients. Here, we showed that up-regulation of miRNA was not commonly found in this limited number of patients, and four miRNAs (miR-26a, miR-29c, miR-30c, miR-30e-5p) were down-regulated as a common marker in patients with a 1-3 grade of disease. Our data suggest that instead of up-regulation of carcinogenic miRNAs, loss of regulation of these miRNA may be critical for bladder tumor development in patients.
authors.affiliation: Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Jie Fang Road, Hangzhou, Zhejiang, People's Republic of China. gwang59@gmail.com
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Honghe
authors.initials: H
authors.lastname: Zhang
authors.forename: Huadong
authors.initials: H
authors.lastname: He
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Tong
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Guodong
authors.initials: G
authors.lastname: Liao
authors.forename: Zhaodian
authors.initials: Z
authors.lastname: Chen
authors.forename: Caigan
authors.initials: C
authors.lastname: Du
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D008875:Middle Aged; D015854:Up-Regulation; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
chemical_list: D035683:MicroRNAs