An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation.
Previous research indicates that drug motivational systems are instantiated in structures that process information related to incentive, motivational drive, memorial, motor/habit, craving, and cognitive control processing. The present research tests the hypothesis that activity in such systems will be powerfully affected by the combination of drug anticipation and drug withdrawal. Event-related fMRI was used to examine activation in response to a preinfusion warning cue in two experimental sessions that manipulated withdrawal status. Significant cue-induced effects were seen in the caudate, ventral anterior nucleus of the thalamus, the insula, subcallosal gyrus, nucleus accumbens, and anterior cingulate. These results suggest that withdrawal and nicotine anticipation produce (1) different motor preparatory and inhibitory response processing and (2) different craving related processing.
Gloria
Rebecca
R
Department of Psychology, University of Wisconsin, Madison, Wisconsin 53706, USA. rgloria@wisc.edu
Angelos
Lisa
L
Schaefer
Hillary S
HS
Davis
James M
JM
Majeskie
Matthew
M
Richmond
Burke S
BS
Curtin
John J
JJ
Davidson
Richard J
RJ
Baker
Timothy B
TB
D000328:Adult; D001921:Brain / Q000473:pathology; D002248:Carbon Monoxide / Q000097:blood; D003463:Cues; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000473:pathology* / Q000523:psychology*; D014029:Tobacco Use Disorder / Q000473:pathology* / Q000523:psychology*
D002248:Carbon Monoxide