A highly selective and sensitive fluorescent turn-on sensor for Hg2+ and its application in live cell imaging.
A boron-dipyrromethene (BODIPY) derivative containing a tridentate diaza-oxa ligand (8H-BDP) was synthesized as a fluorescent turn-on chemosensor for Hg(2+) with high sensitivity (detection limit < or = 2 ppb), a rapid response time (< or = 5 seconds) and specific selectivity over other cations under physiological conditions and in live cells according to the confocal fluorescence microscopy experiment.
Lu
Hua
H
State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing, 210093, PR China.
Xiong
Liqin
L
Liu
Hanzhuang
H
Yu
Mengxiao
M
Shen
Zhen
Z
Li
Fuyou
F
You
Xiaozeng
X
D001896:Boron Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D002470:Cell Survival; D018360:Crystallography, X-Ray; D015195:Drug Design; D005456:Fluorescent Dyes / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008628:Mercury / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D014867:Water / Q000737:chemistry
C543051:8-(3-N-(2-pyridylmethyl)amino-4-hydroxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D014867:Water; D008628:Mercury