Molecular determinants of fluoroquinolone antibacterial agents pharmacokinetics.
This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.
Levêque
Dominique
D
Pharmacy, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. dominique.leveque@chru-strasbourg.fr
Jehl
François
F
D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000493:pharmacokinetics*; D001692:Biological Transport; D001711:Biotransformation; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D004347:Drug Interactions; D024841:Fluoroquinolones / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D057093:Orphan Nuclear Receptors / Q000187:drug effects / Q000378:metabolism; D011110:Polymorphism, Genetic
D018528:ATP-Binding Cassette Transporters; D000900:Anti-Bacterial Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D024841:Fluoroquinolones; D057093:Orphan Nuclear Receptors; D003577:Cytochrome P-450 Enzyme System