title: [Two cases of gastric cancer expressing Glypican 3, but producing AFP with different lectin affinity].
abstract: We encountered 2 cases of AFP-producing gastric cancer. In the first patient, an 82-year-old man was found to have advanced type II advanced carcinoma in the stomach with a massive tumor embolus in the portal vein. In the second case, an 80-year-old man was given a diagnosis of multiple liver metastases of gastric cancer with portal vein thrombosis. Our diagnosis of gastric cancer in both cases was AFP-producing. It was supposed that the elevation of serum level of AFP might be caused by enteroblastic differentiation in the first case and hepatoid differentiation in the second case. Although, in both cases, the biopsy specimens of the gastric neoplasm proved moderately to poorly differentiated adenocarcinoma without hepatoid differentiation, the localization of Glypican 3 in gastric cancer cells was observed using immunostaining with a monoclonal antibody. In both cases, Glypican 3 was a sensitive and useful marker for AFP-producing gastric cancer with or without hepatoid differentiation.
authors.affiliation: Department of Gastroenterology, Internal Medicine, Showa University School of Medicine.
authors.forename: Chitose
authors.initials: C
authors.lastname: Oishi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Baba
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Kubota
authors.forename: Yu
authors.initials: Y
authors.lastname: Shimotsuma
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kitamura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Honma
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Ikegami
authors.forename: Momoko
authors.initials: M
authors.lastname: Inokuchi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Umeda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Michio
authors.initials: M
authors.lastname: Imawari
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D053673:Glypicans / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013274:Stomach Neoplasms / Q000378:metabolism*; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D053673:Glypicans; D000509:alpha-Fetoproteins