Ceftriaxone-induced toxic hepatitis.
Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure. The advantages of a long half-life, wide spectrum, high tissue penetration rate, and a good safety profile, make ceftriaxone, a third-generation cephalosporin, a frequent choice in the treatment of childhood infections. Previous studies have reported a few cases of high aspartate aminotransferase and alanine aminotransferase levels, along with three cases of hepatitis caused by ceftriaxone. Here, we report a case of drug-induced toxic hepatitis in a patient who was treated with ceftriaxone for acute tonsillitis.
Peker
Erdal
E
Department of Pediatrics, Medical University of Yuzuncu Yil, 65100 Van, Turkey. pekererdal@hotmail.com
Cagan
Eren
E
Dogan
Murat
M
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D002443:Ceftriaxone / Q000009:adverse effects* / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002648:Child; D004342:Drug Hypersensitivity; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone