title: CuBr-mediated oxyalkylation of vinylarenes under aerobic conditions via cleavage of sp3 C-H bonds alpha to oxygen.
abstract: A novel difunctionalization reaction of vinylarenes with cyclic ethers has been developed by copper catalysis via direct activation of alpha-sp(3) C-H bonds of oxygen in the presence of 1-1.2 equiv of TBHP under mild aerobic conditions. The reaction shows excellent regioselectivities and good functional group tolerance to give the oxyalkylated products of vinylarenes.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Cheng
authors.forename: Lehao
authors.initials: L
authors.lastname: Huang
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Zhang