title: High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster.
abstract: High frequency stimulation (HFS) of the internal pallidum is effective for the treatment of dystonia. Only few studies have investigated the effects of stimulation on the activity of the cortex-basal ganglia network. We here assess within this network the effect of entopeduncular nucleus (EP) HFS on the expression of c-Fos and cytochrome oxidase subunit I (COI) in the dt(sz)-hamster, a well-characterized model of paroxysmal dystonia. In dt(sz)-hamsters, we identified abnormal activity in motor cortex, basal ganglia and thalamus. These structures have already been linked to the pathophysiology of human dystonia. EP-HFS (i) increased striatal c-Fos expression in controls and dystonic hamsters and (ii) reduced thalamic c-Fos expression in dt(sz)-hamsters. EP-HFS had no effect on COI expression. The present results suggest that EP-HFS induces a new network activity state which may improve information processing and finally reduces the severity of dystonic attacks in dt(sz)-hamsters.
authors.affiliation: Université Victor Segalen - Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, 33076 Bordeaux Cedex, France.
authors.forename: René
authors.initials: R
authors.lastname: Reese
authors.forename: Giselle
authors.initials: G
authors.lastname: Charron
authors.forename: Agnès
authors.initials: A
authors.lastname: Nadjar
authors.forename: Incarnation
authors.initials: I
authors.lastname: Aubert
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Thiolat
authors.forename: Melanie
authors.initials: M
authors.lastname: Hamann
authors.forename: Angelika
authors.initials: A
authors.lastname: Richter
authors.forename: Erwan
authors.initials: E
authors.lastname: Bezard
authors.forename: Wassilios G
authors.initials: WG
authors.lastname: Meissner
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D003342:Corpus Striatum / Q000503:physiopathology; D006224:Cricetinae; D046690:Deep Brain Stimulation; D004421:Dystonia / Q000503:physiopathology / Q000628:therapy*; D004558:Electric Stimulation; D003576:Electron Transport Complex IV / Q000378:metabolism; D020392:Entopeduncular Nucleus / Q000503:physiopathology*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D012720:Severity of Illness Index
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D003576:Electron Transport Complex IV