title: 99mTechnetium-methylene diphosphonate bone imaging using low-intensity pulsed ultrasound: promotion of bone formation during mandibular distraction osteogenesis in dogs.
abstract: Our objective was to assess the value of (99m)technetium-methylene diphosphonate ((99m)Tc-MDP) bone imaging in the use of low-intensity pulsed ultrasound to promote bony formation during mandibular distraction osteogenesis in dogs. The body of the mandibles in 7 dogs were cut between the first and the second premolar and were lengthened at the rate of 1mm/day, twice a day, for 20 days. During the period of distraction one lateral distraction gap was irradiated with low-intensity pulsed ultrasound (LIPUS) for 10min twice a day, and the other side was used as control. Serial radiographic inspections were made at different periods (0, 1, 2, 4, 6, 8, and 12 weeks) during the consolidation phase, followed by a plain radiograph and histological examination. The (99m)Tc-MDP imaging showed that the ratio of bone formation on the LIPUS-treated side was significantly higher than that on the control side during the early period of consolidation (before the 4th week), but later this was reversed and there were no significant differences between the two sides by the 12th week. Plain radiographs and histological examination showed that the new bone on the experimental side had matured earlier than that on the control side. Radionuclide bone imaging is a good way to assess the formation of bone after distraction osteogenesis.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University (FMMU), 145 Western Changle Road, Xi'an, 710032, PR China.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Ding
authors.forename: Guoquan
authors.initials: G
authors.lastname: Li
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ao
authors.forename: Libin
authors.initials: L
authors.lastname: Zhou
authors.forename: Qin
authors.initials: Q
authors.lastname: Ma
authors.forename: Yanpu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D004285:Dogs; D008334:Mandible / Q000000981:diagnostic imaging* / Q000601:surgery*; D019857:Osteogenesis, Distraction; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate; D014464:Ultrasonic Therapy / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate