Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: gene x environment hypotheses tested via a randomized prevention design.
A randomized prevention design was used to investigate a moderation effect in the association between a polymorphism in the SCL6A4(5HTT) gene at 5-HTTLPR and increases in youths' risk behavior initiation. Participation in the Strong African American Families (SAAF) program was hypothesized to attenuate the link between 5-HTTLPR status and risk behavior initiation. Youths (N = 641, M age = 11.2 years) were assigned randomly to a SAAF or control condition. Risk behavior initiation across 29 months was linked positively with the 5-HTTLPR genotype and negatively with SAAF participation. Control youths at genetic risk initiated risk behavior at twice the rate of SAAF youths at genetic risk and youths not at genetic risk in either condition.
Brody
Gene H
GH
Center for Family Research, University of Georgia, 1095 College Station Road, Athens, GA 30602-4527, USA. gbrody@uga.edu
Beach
Steven R H
SR
Philibert
Robert A
RA
Chen
Yi-fu
YF
Murry
Velma McBride
VM
D001741:Black or African American / Q000235:genetics* / Q000523:psychology; D017028:Caregivers; D002648:Child; D002652:Child Behavior / Q000523:psychology*; D005260:Female; D005838:Genotype; D005845:Georgia; D006801:Humans; D007604:Juvenile Delinquency / Q000517:prevention & control / Q000523:psychology*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012309:Risk-Taking; D012424:Rural Population; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology; D011795:Surveys and Questionnaires
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins