title: Coexistence of a clear cell adenocarcinoma and an adenosarcoma with a heterologous rhabdomyosarcoma in an endometriotic cyst of the ovary: a case study.
abstract: A rare case of a clear cell adenocarcinoma and an adenosarcoma coexisting with a heterologous rhabdomyosarcoma in an endometriotic cyst of the ovary is reported. The tumor was composed of a cystic area and a solid area arising from the cyst wall. In the cystic lesion, a detached polypoid mass was also identified. The cyst wall was lined with a single layer of endometrial-type cells, whereas the solid area was composed of a clear cell adenocarcinoma. In the detached polypoid mass, an exophytic leaf-like pattern containing benign endometrial-type cells and squamous epithelial and rhabdomyosarcoma components, which were positive for desmin and myoglobin, was observed. Using X-chromosomal clonality assay, these clear cell adenocarcinoma and adenosarcoma components showed patterns of polyclonality. To the authors' knowledge, this is the first reported case of a clear cell adenocarcinoma and an adenosarcoma coexisting with heterologous rhabdomyosarcoma in an endometriotic cyst of the ovary.
authors.affiliation: Department of Clinical Laboratory Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
authors.forename: Hironao
authors.initials: H
authors.lastname: Yasuoka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujimoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Fujita
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamasaki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kashihara
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Nishio
authors.forename: Rieko
authors.initials: R
authors.lastname: Kodama
authors.forename: Michiya
authors.initials: M
authors.lastname: Inagaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Oishi
authors.forename: Tokio
authors.initials: T
authors.lastname: Sanke
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D018195:Adenosarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D004715:Endometriosis / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D010048:Ovarian Cysts / Q000378:metabolism / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011944:Receptors, Androgen / Q000235:genetics; D012208:Rhabdomyosarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D011944:Receptors, Androgen