Corneal transparency: genesis, maintenance and dysfunction.
Optimal vision is contingent upon transparency of the cornea. Corneal neovascularization, trauma and, surgical procedures such as photorefractive keratectomy and graft rejection after penetrating keratoplasty can lead to corneal opacification. In this article we identify the underlying basis of corneal transparency and factors that compromise the integrity of the cornea. With evidence from work on animal models and clinical studies, we explore the molecular mechanisms of both corneal avascularity and its dysfunction. We also seek to review therapeutic regimens that can safely salvage and restore corneal transparency.
Qazi
Yureeda
Y
Department of Ophthalmology, John Moran Eye Center, University of Utah, Salt Lake City 84132, UT, USA. yureeda.qazi@hsc.utah.edu
Wong
Gilbert
G
Monson
Bryan
B
Stringham
Jack
J
Ambati
Balamurali K
BK
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D003315:Cornea / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery; D003316:Corneal Diseases / Q000628:therapy*; D016510:Corneal Neovascularization / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000379:methods; D018903:Photorefractive Keratectomy / Q000379:methods
D020533:Angiogenesis Inhibitors