title: Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models.
abstract: BACKGROUND
  The roots of Arnebia densiflora (Nordm.) Ledeb. (Boraginaceae), which is an endemic plant for Turkey, have been used for healing of wounds in folk medicine. The extract of the roots in olive oil and mostly the root barks was applied onto open wounds for rapid healing.
  
  
  OBJECTIVE
  To evaluate the wound healing activity of the roots, extracts were prepared with different solvents; hexane, chloroform, ethyl acetate and methanol, respectively from the roots of Arnebia densiflora.
  
  
  METHODS
  Incision by using tensiometer and excision models were employed on mice and rats.
  
  
  RESULTS
  Significant wound healing activity was observed with the ointment formulation prepared by using hexane extract at 1% concentration on the mentioned models. The results of histopathological examination supported the outcome of both incision and excision wound models. The wound healing effect was comparatively evaluated with a reference ointment Madecassol.
  
  
  CONCLUSIONS
  The experimental data demonstrated that Arnebia densiflora displayed remarkable wound healing activity.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey. esrak@gazi.edu.tr
authors.forename: Esra Küpeli
authors.initials: EK
authors.lastname: Akkol
authors.forename: Ufuk
authors.initials: U
authors.lastname: Koca
authors.forename: Ipek
authors.initials: I
authors.lastname: Peşin
authors.forename: Demet
authors.initials: D
authors.lastname: Yilmazer
authors.forename: Gülnur
authors.initials: G
authors.lastname: Toker
authors.forename: Erdem
authors.initials: E
authors.lastname: Yeşilada
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D028082:Boraginaceae; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D009824:Ointments; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D014315:Triterpenes / Q000494:pharmacology / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D009824:Ointments; D010936:Plant Extracts; D014315:Triterpenes; C004446:asiaticoside