title: The dynamic side of the Hofmeister effect: a single-molecule nanopore study of specific complex formation.
abstract: Beyond measurements of equilibria: An alpha-hemolysin nanopore is used as a single-molecule sensor to follow the effects of different salts on the complexation reaction of gamma-cyclodextrin and adamantane carboxylate (see picture). The kinetics underlying the dynamic equilibrium are studied to reveal qualitatively different dynamic actions of various cosolute salts.
authors.affiliation: Laboratory of Physical and Structural Biology, Program in Physical Biology, NICHD, National Institutes of Health, 9000 Rockville Pike, Bldg. 9, Bethesda, MD 20892, USA.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Gurnev
authors.forename: Daniel
authors.initials: D
authors.lastname: Harries
authors.forename: V Adrian
authors.initials: VA
authors.lastname: Parsegian
authors.forename: Sergey M
authors.initials: SM
authors.lastname: Bezrukov
mesh_terms: D000218:Adamantane / Q000737:chemistry; D006460:Hemolysin Proteins / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D016062:Porosity; D013816:Thermodynamics; D047408:gamma-Cyclodextrins / Q000737:chemistry
chemical_list: D006460:Hemolysin Proteins; D047408:gamma-Cyclodextrins; C023792:gamma-cyclodextrin; D000218:Adamantane