Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification.
Early control of HIV-1 infection is determined by a balance between the host immune response and the ability of the virus to escape this response. Studies using single-genome amplification now reveal new details about the kinetics and specificity of the CD8(+) T cell response and the evolution of the virus during early HIV infection.
Brumme
Zabrina L
ZL
Ragon Institute of MGH, MIT and Harvard, Charlestown MA 02129, USA.
Walker
Bruce D
BD
D019143:Evolution, Molecular; D016679:Genome, Viral; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D021141:Nucleic Acid Amplification Techniques; D012641:Selection, Genetic; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D014766:Viremia