Intraspecies signaling involving the diffusible signal factor BDSF (cis-2-dodecenoic acid) influences virulence in Burkholderia cenocepacia.
Burkholderia cenocepacia produces a diffusible fatty acid signal molecule, cis-2-dodecenoic acid (BDSF), that has been implicated in interspecies and interkingdom communication. Here, we show that BDSF also acts as an intraspecies signal in B. cenocepacia to control factors contributing to virulence of this major opportunistic pathogen.
Ryan
Robert P
RP
BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, University College Cork, Cork, Ireland.
McCarthy
Yvonne
Y
Watt
Steven A
SA
Niehaus
Karsten
K
Dow
J Maxwell
JM
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D019121:Burkholderia Infections / Q000382:microbiology; D016956:Burkholderia cepacia / Q000187:drug effects / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism* / Q000494:pharmacology; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects / Q000235:genetics; D005816:Genetic Complementation Test; D007814:Larva / Q000382:microbiology; D009036:Moths / Q000382:microbiology; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D014774:Virulence / Q000187:drug effects / Q000235:genetics
C527562:2-dodecenoic acid; D001426:Bacterial Proteins; D005229:Fatty Acids, Monounsaturated