Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population.
BACKGROUND
The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been reported to associate with human longevity. However, little information is available in a Han Chinese longevity population.Therefore, we investigated the association of the ACE gene insertion/ deletion polymorphism with longevity in a Han Chinese population.


METHODS
We compared the distribution of ACE insertion/deletion genotype and allele frequencies in two groups: a longevity group (399 subjects) aged over 90 years and a control group (302 subjects) aged less than 60 years.


RESULTS
No difference in genotype and allele frequencies of the ACE gene insertion/deletion polymorphism was observed between the longevity group and the control group.When adjusting for gender, the difference between the longevity group and the control group was also not significant regarding the frequencies of the genotypes (male, p=0.994 and female, p=0.797) as well as allele frequencies (male, p=0.969 and female, p=0.884).


CONCLUSIONS
No association of the ACE gene insertion/deletion polymorphism with longevity was observed in our Han Chinese population.
Yang
Jian-Kang
JK
Laboratory for Conservation and Utilisation of Bio-resource, Yunnan University, Kunming, China.
Gong
Yuan-Ying
YY
Xie
Liang
L
Lian
Shi-Gang
SG
Yang
Juan
J
Xu
Liang-You
LY
Gao
Shou-Jun
SJ
Zhang
Ya-Ping
YP
D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A