Association of the hypoxia inducible factor-1alpha gene polymorphisms with gastric cancer in Tibetans.
To determine how single nucleotide polymorphisms (SNPs) in the hypoxia inducible factor-1alpha (HIF-1alpha) gene coding regions affect gastric cancer, the authors conducted an association study of the HIF-1alpha polymorphisms C1772T and G1790A for a Tibet population. DNA was extracted from peripheral blood of 87 gastric cancer patients and 106 controls and analyzed using the polymerase chain reaction/ligase detection reaction test for HIF-1alpha polymorphisms. There was a significant increase in the frequency of the GA 1790 genotype in patients with gastric cancer compared with healthy controls (OR 2.93; 95% CI 1.06-8.06). The genotype frequency of the HIF-1alpha G1790A allele A is higher in gastric cancer groups than in controls (OR 2.78; 95% CI 1.03-7.45). As for the C1772T polymorphism, no positive correlation was found between gastric cancer patients and controls (P = 0.06). Our results suggest that the HIF-1alpha G1790A polymorphism may be associated with gastric cancer in Tibetans.
Li
Kang
K
Gastroenterology Department of Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. likang820@yahoo.com.cn
Zhang
Yali
Y
Dan
Zeng
Z
Wang
Yi
Y
Ren
Zhuoma Ci
ZC
D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics*; D018609:Tibet
D014408:Biomarkers, Tumor; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit