title: Heterologous prime-boost vaccination.
abstract: An effective vaccine usually requires more than one time immunization in the form of prime-boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime-boost can be done with different types of vaccines containing the same antigens. In many cases such heterologous prime-boost can be more immunogenic than homologous prime-boost. Heterologous prime-boost represents a new way of immunization and will stimulate better understanding on the immunological basis of vaccines.
authors.affiliation: China-US Vaccine Research Center and Department of Infectious Diseases, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China. shan.lu@umassmed.edu
authors.forename: Shan
authors.initials: S
authors.lastname: Lu
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage / Q000276:immunology; D000818:Animals; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000276:immunology; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control; D012106:Research / Q000639:trends; D012107:Research Design; D014611:Vaccination / Q000379:methods*
chemical_list: D016915:AIDS Vaccines; D019496:Cancer Vaccines