title: Health risk assessment procedures for endocrine disrupting compounds within different regulatory frameworks in the European Union.
abstract: In this study we have investigated how different regulatory frameworks in Europe cope with identification and risk assessment of endocrine disrupting compounds (EDCs). Four regulatory groups were selected for the investigation: existing industrial chemicals, environmental pollutants in food, pharmaceuticals and plant protection products. The legislation and guidelines for each of these groups were scrutinized and compared in detail. In addition, one recent European risk assessment document each for three identified EDCs, i.e. bisphenol A, dioxins and vinclozolin, were reviewed and compared. We found that the requirements for toxicity testing and availability and scope of risk assessment guidelines varied between the four regulatory frameworks. Also, the general principles regarding the human relevance of the mode of action identified in animal tests differed in the different risk assessments. In conclusion, there is little conformity in the risk assessment processes between these groups of chemicals. Because of the complicated nature of endocrine disruption, test methods, principles and criteria for data interpretation traditionally used might not be directly applicable to EDCs and further development of a transparent and reliable risk assessment process for this type of substances is needed.
authors.affiliation: Karolinska Institutet, Institute of Environmental Medicine, 171 77 Stockholm, Sweden. anna.beronius@ki.se
authors.forename: Anna
authors.initials: A
authors.lastname: Beronius
authors.forename: Christina
authors.initials: C
authors.lastname: Rudén
authors.forename: Annika
authors.initials: A
authors.lastname: Hanberg
authors.forename: Helen
authors.initials: H
authors.lastname: Håkansson
mesh_terms: D016573:Agrochemicals / Q000032:analysis / Q000633:toxicity; D000818:Animals; D052244:Endocrine Disruptors / Q000032:analysis / Q000633:toxicity*; D004703:Endocrine System / Q000187:drug effects* / Q000473:pathology; D004781:Environmental Exposure / Q000009:adverse effects*; D005062:European Union; D005506:Food Contamination / Q000032:analysis / Q000331:legislation & jurisprudence; D005523:Food Supply / Q000331:legislation & jurisprudence; D033161:Government Regulation; D006801:Humans; D007221:Industry; D018570:Risk Assessment; D018675:Toxicity Tests
chemical_list: D016573:Agrochemicals; D052244:Endocrine Disruptors