The effect of paternal and maternal history of diabetes mellitus on the development of gestational diabetes mellitus.
BACKGROUND
There is an ongoing debate whether maternal diabetes is a more important risk factor for gestational diabetes (GDM) development than paternal diabetes.


OBJECTIVE
To describe the risk of GDM associated with paternal and maternal diabetes, and to further characterise GDM women with maternal diabetes.


METHODS
Case-control study within a population-based GDM screening program in an urban area of Hungary in 2002-2003. All GDM women (no.=133) and an age-matched control group (no.=135) with a mean age of 31 years was evaluated. Blood pressure, anthropometric data, and blood glucose values from a 75 g Oral Glucose Tolerance Test (OGTT) were recorded at 24-28 weeks of gestation. Family history data were by self-report.


RESULTS
Known paternal diabetes was not related to GDM risk [odds ratio (OR) 0.83, 95% confidence interval (CI) 0.35-2.00]. Known maternal diabetes (OR 2.90, 95% CI 0.99-8.49) and diabetes in the maternal line (OR 2.83, 95% CI 1.16-6.89) were both related to GDM after adjustment for body mass index (BMI). GDM women with known maternal diabetes had a higher BMI, 31.6 [9.1] kg/m2 median [interquartile range], than GDM women with or without diabetes in the maternal line, 26.1 [4.9] and 26.3 [6.1] kg/m2, respectively, while figures for fasting glucose during OGTT were 5.2 [0.7] vs 4.4 [1.1] vs 4.9 [0.8] mmol/l respectively (all p<0.05).


CONCLUSIONS
Maternal history of diabetes and history of diabetes in the maternal line seems to be a stronger predictor of GDM than paternal history.
Tabák
A G
AG
National Centre for Diabetes Care, Budapest, Hungary. a.tabak@ucl.ac.uk
Tamás
G
G
Péterfalvi
A
A
Bosnyák
Z
Z
Madarász
E
E
Rákóczi
I
I
Kerényi
Z
Z
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000503:physiopathology*; D016640:Diabetes, Gestational / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D008403:Mass Screening; D010290:Parents; D011247:Pregnancy; D012307:Risk Factors
D001786:Blood Glucose