Bisbenzylisoquinoline alkaloids from Cocculus pendulus.
A new bisbenzylisoquinoline alkaloid, 1,2-dihydrokurramine (1), and four known bisbenzylisoquinoline alkaloids 2-5, along with a morphinan alkaloid 6 were isolated from Cocculus pendulus. The structures for these compounds were deduced by spectroscopic methods. All bisbenzylisoquinoline alkaloids showed inhibitory activities against acetyl- and butyrylcholinesterases.
Atta-ur-Rahman
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
Atia-tul-Wahab
Zia Sultani
S
S
Nawaz
Sarfraz A
SA
Choudhary
M Iqbal
MI
D000110:Acetylcholinesterase / Q000378:metabolism; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D044182:Benzylisoquinolines / Q000737:chemistry* / Q000494:pharmacology; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D031605:Cocculus / Q000737:chemistry*; D004789:Enzyme Activation / Q000187:drug effects; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D000470:Alkaloids; D044182:Benzylisoquinolines; D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase