Dracotanosides A-D, spermidine glycosides from Dracocephalum tanguticum: structure and amide rotational barrier.
Four new spermidine glycosides, dracotanosides A-D (1-4), have been isolated from Dracocephalum tanguticum. These molecules represent the first spermidine glycosides from this plant genus. The structures, including absolute configurations, were determined by spectroscopic and chemical methods. The amide bond rotational barrier of aglycone 1a was calculated by density functional theory (DFT) computation.
Wang
Shu-Qi
SQ
Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, People's Republic of China.
Ren
Dong-Mei
DM
Xiang
Feng
F
Wang
Xiao-Ning
XN
Zhu
Chang-Jun
CJ
Yuan
Hui-Qing
HQ
Sun
Ling-Mei
LM
Lv
Bei-Bei
BB
Sun
Xue-Jie
XJ
Lou
Hong-Xiang
HX
D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D013095:Spermidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D013095:Spermidine