title: Primary splenic peripheral nerve sheath tumour in a dog.
abstract: An 8-year-old crossbred dog was presented with a one-month history of progressive weakness, respiratory impairment and abdominal distension. Surgical exploration revealed the presence of a splenic mass that infiltrated the mesentery and was adherent to the stomach and pancreas. The mass was composed of highly cellular areas of spindle-shaped cells arranged in interlacing bundles, streams, whorls and storiform patterns (Antoni A pattern) and less cellular areas with more loosely arranged spindle to oval cells (Antoni B pattern). The majority of neoplastic cells expressed vimentin, S-100 and glial fibrillary acidic protein (GFAP), but did not express desmin, alpha-smooth muscle actin or factor VIII. These morphological and immunohistochemical findings characterized the lesion as a malignant peripheral nerve sheath tumour (PNST). Primary splenic PNST has not been documented previously in the dog.
authors.affiliation: Institute of Animal Pathology, Vetsuisse Faculty, University of Berne, Switzerland.
authors.forename: W
authors.initials: W
authors.lastname: Bergmann
authors.forename: I A
authors.initials: IA
authors.lastname: Burgener
authors.forename: P
authors.initials: P
authors.lastname: Roccabianca
authors.forename: U
authors.initials: U
authors.lastname: Rytz
authors.forename: M
authors.initials: M
authors.lastname: Welle
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D037901:Euthanasia, Animal; D017809:Fatal Outcome; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007150:Immunohistochemistry / Q000662:veterinary; D018317:Nerve Sheath Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D009418:S100 Proteins / Q000032:analysis; D013160:Splenic Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D014746:Vimentin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D014746:Vimentin