Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
This work describes the synthesis and anti-inflammatory properties of a pentadienone derivative, HB2. The treatment with HB2 produced anti-oedematogenic, anti-inflammatory and antinociception without change locomotors performance. Finally, HB2 reduced the nitric oxide and prostaglandin E(2) production on RAW 264.7 cells stimulated with LPS without changing the cell viability. Taken together, our results show, for the first time, that HB2 can modulate the inflammatory response when administered to mice.
Paulino
Niraldo
N
Grupo de Pesquisa e Desenvolvimento de Biomedicamentos (BIOMED), Universidade Bandeirante de São Paulo, São Paulo, Brazil. niraldop@yahoo.com.br
Rodrigues
Naiara Carvalho
NC
Pardi
Paulo Celso
PC
Suárez
José Agustín Pablo Quincoces
JA
dos Santos
Reginaldo Pereira
RP
Scremin
Amarilis
A
Vogel
Christian
C
Feist
Holger
H
Michalik
Dirk
D
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000840:Anisoles / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015232:Dinoprostone / Q000378:metabolism; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*
C543314:1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one; D000700:Analgesics; D000840:Anisoles; D000893:Anti-Inflammatory Agents; D007659:Ketones; D016328:NF-kappa B; D009569:Nitric Oxide; D015232:Dinoprostone