title: [The diagnosis of anthracycline-induced cardiac damage and heart failure].
abstract: Routine examinations during chemotherapy containing anthracyclines evaluate heart function before treatment and monitor cardiotoxic effects during and after therapy. A number of methods are useful in cardiac assessment, including electrocardiography, radiology techniques (RTG, CT, MRI,PET-CT, PET-MRI), echocardiography, radioisotope imaging techniques (scintigraphy, MUGA,PET), and ultra-structure evaluation in biopsy samples. Nevertheless, there is a continuous need for new methods to predict future damage at the initial stages of cardiac changes. In recent years the therapeutic usefulness of biochemical blood parameters in anthracycline-treated patients has been assessed. The levels of cardiac troponins (cTnI, cTnT), natriuretic peptides (ANP, BNP), and endothelin 1 have been included in the studies. Heart-type fatty acid binding protein (H-FABP) is another promising factor showing cardiomyocytic impairment. However, the clinical use of biochemical parameters in diagnosing anthracycline-related cardiotoxicity is still a controversial issue.
authors.affiliation: Katedra i Zakład Patomorfologii Klinicznej, UM w Lublinie, 20-950 Lublin. ave123@wp.pl
authors.forename: Jarosław
authors.initials: J
authors.lastname: Dudka
authors.forename: Franciszek
authors.initials: F
authors.lastname: Burdan
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Korga
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Dyndor
authors.forename: Iwona
authors.initials: I
authors.lastname: Syroka
authors.forename: Justyna
authors.initials: J
authors.lastname: Zieba
authors.forename: Dorota
authors.initials: D
authors.lastname: Lewkowicz
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Korobowicz-Markiewicz
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects*; D054715:Cardiotoxins / Q000009:adverse effects*; D016232:Endothelins / Q000097:blood; D006333:Heart Failure / Q000097:blood / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D045265:Natriuretic Peptides / Q000097:blood; D014336:Troponin / Q000097:blood
chemical_list: D018943:Anthracyclines; D054715:Cardiotoxins; D016232:Endothelins; D045265:Natriuretic Peptides; D014336:Troponin