Syndrome of inappropriate antidiuretic hormone secretion possibly associated with amantadine therapy in Parkinson disease.
OBJECTIVE
To report a patient who developed a syndrome of inappropriate antidiuretic hormone secretion (SIADH) related with amantadine therapy.


METHODS
A 66-year-old woman, diagnosed with Parkinson disease, developed asthenia, anorexia, weight loss, lethargy and feeling of muscle weakness, and severe hyponatremia, with diagnostic criteria for SIADH, after exposure to amantadine. After amantadine withdrawal, these symptoms disappeared, and sodium levels reached normal values gradually.


CONCLUSIONS
The SIADH should be taken into account among the possible side effects of amantadine.
Alonso Navarro
Hortensia
H
Department of Medicine-Neurology, Hospital Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Sánz-Aiz
Angel
A
Izquierdo
Laura
L
Jiménez Jiménez
Félix Javier
FJ
D000368:Aged; D000547:Amantadine / Q000009:adverse effects*; D000978:Antiparkinson Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D010300:Parkinson Disease / Q000188:drug therapy; D012964:Sodium / Q000652:urine
D000978:Antiparkinson Agents; D012964:Sodium; D000547:Amantadine