Titanium binolate catalyzed aminolysis of meso aziridines: a highly enantioselective and direct access to 1,2-diamines.
It's as simple as that: An in situ prepared chiral catalyst from the commercially available compounds Ti(OiPr)(4) and (R)-binol catalyzes the highly enantioselective ring-opening of meso-aziridines 1 with anilines 2 and furnishes valuable chiral 1,2-diamines 3 in high yields and up to 99 % ee.(R)-binol=(R)-2,2'-dihydroxy-1,1'-binaphthyl.
Peruncheralathan
Saravanan
S
Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 4103 Leipzig, Germany.
Teller
Henrik
H
Schneider
Christoph
C