title: Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population.
abstract: OBJECTIVE
  To evaluate the effect of TCF7L2 on genetic susceptibility of type 2 diabetes (T2DM) in East Asian population by using the meta-analysis.
  
  
  METHODS
  Search all the publications about the association between TCF7L2 and T2DM in East Asian population from PubMed, CNKI and abstracts of major diabetes conferences. Perform the meta-analysis of all the validated studies and evaluate the association between rs7903146 T allele, rs12255372 T allele, rs11196205 C allele, rs290487 C allele and rs11196218 G allele of TCF7L2 and the risk of T2DM.
  
  
  RESULTS
  Eleven studies from nine eligible papers and one unpublished study of ours were included in the meta-analysis. Ten eligible studies were analyzed for rs7903146, five were analyzed for rs12255372 and rs11196205, and three were analyzed for rs290487 and rs11196218. We found that four SNPs (rs7903146, rs12255372, rs11196205, rs290487) in TCF7L2 were significantly associated with T2DM in East Asian populations. The rs11196218 also showed a marginal association. The estimated population-attributable risk (PAR) associated with analyzed SNPs ranged from 2% to 7%.
  
  
  CONCLUSIONS
  SNPs in TCF7L2 were strongly associated with the risk of T2DM in East Asian population. But the contribution of its genetic variants to the epidemic of type 2 diabetes in East Asian was relatively low.
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, PR China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Luo
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Wang
authors.forename: Xueyao
authors.initials: X
authors.lastname: Han
authors.forename: Qian
authors.initials: Q
authors.lastname: Ren
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Xiuying
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiuqin
authors.initials: X
authors.lastname: Sun
authors.forename: Xianghai
authors.initials: X
authors.lastname: Zhou
authors.forename: Linong
authors.initials: L
authors.lastname: Ji
mesh_terms: D044466:Asian People / Q000235:genetics; D015982:Bias; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D007723:Korea; D012307:Risk Factors; D051820:TCF Transcription Factors / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein; D044465:White People / Q000235:genetics
chemical_list: D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein