title: Fine mapping a quantitative trait locus on horse chromosome 2 associated with radiological signs of navicular disease in Hanoverian warmblood horses.
abstract: Navicular disease or podotrochlosis is one of the main causes of progressive forelimb lameness in warmblood horses. The objective of this study was to refine a quantitative trait locus on horse chromosome 2 for radiological alterations in the contour of the navicular bone (RAC) in Hanoverian warmblood horses. Genotyping was performed in 192 Hanoverian warmblood horses from 17 paternal half-sib groups. The marker set was extended to 58 informative microsatellites including nine newly developed microsatellites. QTL for RAC could be delineated at 32.50-43.13 Mb and a further new QTL for RAC could be identified at 59.08-65.14 Mb. The markers ABGe342 and ABGe343 reached the highest multipoint Z(mean) and LOD scores at 34.42 and 35.23 Mb with genome-wide error probabilities of P = 0.013 and P = 0.064. In addition, significant associations of markers and haplotypes within the QTL could be shown. The results support the location of the QTL on ECA2 associated with RAC. This work is a further step towards the development of a marker test for navicular disease in Hanoverian warmblood horses.
authors.affiliation: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany.
authors.forename: M S
authors.initials: MS
authors.lastname: Lopes
authors.forename: U
authors.initials: U
authors.lastname: Diesterbeck
authors.forename: A
authors.initials: A
authors.lastname: da Câmara Machado
authors.forename: O
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D005534:Foot Diseases / Q000235:genetics / Q000662:veterinary*; D055106:Genome-Wide Association Study; D006734:Horse Diseases / Q000235:genetics*; D006736:Horses; D040641:Quantitative Trait Loci