Is polymorphism within eNOS gene associated with the late onset of myocardial infarction? A pilot study.
BACKGROUND
Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a potent vasodilator. Several polymorphisms in the eNOS gene have been described, some of them being linked with the increased risk of cardiovascular disease, coronary heart disease (CHD), and coronary spasm.


RESULTS
We studied 3 polymorphisms within the gene of eNOS (-786T/C, G10T, and 894 G/T) in patients with their first myocardial infarction (MI) younger than 45 years and in healthy volunteers. We found the relation between the occurrence of eNOS 894G allele and the Gensini score, which describes the severity of CHD (P = .020).


CONCLUSIONS
The fact that first clinical manifestation of MI occurred in G carriers when the atherosclerotic plaque was much more advanced than in T carriers may suggest that wild-type genotype provided a better compensatory mechanisms due to NO synthesis and/or release. The polymorphisms within eNOS gene G10T, 894G/T, and -786T/C were not associated with the increased risk of MI.
Gluba
Anna
A
Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Poland. aniagluba@yahoo.pl
Banach
Maciej
M
Rysz
Jacek
J
Piotrowski
Grzegorz
G
Fendler
Wojciech
W
Pietrucha
Tadeusz
T
D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D009569:Nitric Oxide / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000235:genetics* / Q000378:metabolism; D016017:Odds Ratio; D010641:Phenotype; D010865:Pilot Projects; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors
D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III