A new dibenzofuran and further constituents from the stems of Pourthiaea lucida with inhibitory activity on superoxide generation by neutrophils.
A new dibenzofuran, lucidafuran (1), was isolated from the stems of Pourthiaea lucida, together with eight known compounds. The structure of this new compound was determined through NMR and mass-spectrometric analyses. Among the isolated compounds, lucidafuran (1) and aucuparin (3) exhibited potent inhibitory activity against fMLP-induced superoxide (O(*-)(2)) production by human neutrophils with IC(50) values of 18.7+/-4.4 and 17.0+/-6.8 microM, resp.
Chen
Jih-Jung
JJ
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
Luo
Yu-Ting
YT
Liao
Chang-Hui
CH
Chen
Ih-Sheng
IS
Liaw
Chih-Chuang
CC
D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D018547:Plant Stems / Q000737:chemistry; D027824:Rosaceae / Q000737:chemistry*; D013481:Superoxides / Q000378:metabolism*
C542669:4-methoxydibenzo(b,d)furan-2,3-diol; D001572:Benzofurans; D016166:Free Radical Scavengers; D013481:Superoxides; C023614:dibenzofuran