title: Methimazole-induced antineutrophil cytoplasmic antibody-associated diffuse alveolar haemorrhage in a Chinese woman with Graves' disease.
abstract: We report on a case of diffuse alveolar haemorrhage in a Chinese woman due to methimazole-induced antineutrophil cytoplasmic antibodies. A literature search for anti-thyroid drugs associated with antineutrophil cytoplasmic antibody-induced diffuse alveolar haemorrhages is reviewed. Diffuse alveolar haemorrhage is a rare complication of thiourea agents and the treatment often requires corticosteroids or other immunosuppressants, together with withdrawal of the causative agent.
authors.affiliation: Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong.
authors.forename: Emmy Y F
authors.initials: EY
authors.lastname: Lau
authors.forename: S Y
authors.initials: SY
authors.lastname: So
authors.forename: Eric
authors.initials: E
authors.lastname: Chan
authors.forename: Janette
authors.initials: J
authors.lastname: Kwok
authors.forename: John
authors.initials: J
authors.lastname: Ma
authors.forename: Annie W C
authors.initials: AW
authors.lastname: Kung
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015897:Comorbidity; D005260:Female; D006111:Graves Disease / Q000188:drug therapy* / Q000453:epidemiology; D006470:Hemorrhage / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology / Q000276:immunology*; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use; D011650:Pulmonary Alveoli; D014657:Vasculitis / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D008713:Methimazole