title: Synthesis and investigation of tryptophan-amphotericin B conjugates.
abstract: Anchors aweigh! The synthesis of tryptophan-amphotericin B conjugates (see figure) is described. The membrane-anchoring effect of tryptophane was thus combined with the pore-formation effect of amphotericin B leading to high channel activity in sterol-free liposomes.
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zürich, Hönggerberg, Zürich, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zumbuehl
authors.forename: Pasquale
authors.initials: P
authors.lastname: Stano
authors.forename: Marc
authors.initials: M
authors.lastname: Sohrmann
authors.forename: Rolf
authors.initials: R
authors.lastname: Dietiker
authors.forename: Mathias
authors.initials: M
authors.lastname: Peter
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira
mesh_terms: D000666:Amphotericin B / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008081:Liposomes / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D011188:Potassium / Q000378:metabolism; D014364:Tryptophan / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B; D014364:Tryptophan; D011188:Potassium