title: Nanoparticle albumin-bound (NAB) technology is a promising method for anti-cancer drug delivery.
abstract: Albumin is a versatile drug carrier in anti-cancer drug delivery system and it also has an actively targeting capacity to tumors. Recently, nanoparticle albumin-bound (nab) paclitaxel (nab-paclitaxel; Abraxane) has been approved in 2006 for use in patients with metastatic breast cancer who have failed in the combination chemotherapy, and so the nab-technology has attracted much interest in the anti-cancer drug delivery system. The details about the preparation, characterization and evaluation of nab-paclitaxel (ABI-007) are discussed. The pharmacokinetics, pharmacodynamics and the clinical trials of ABI-007 are also reviewed. Furthermore, the recent applications of nab-technology in the anti-cancer drug delivery systems are summarized by virtue of the patents pertaining to nab-technology. To sum up, nab-technology has a great potential of being applied extensively in the field of anti-cancer agents delivery in the future in order to acquire the good safety and better therapeutical effect.
authors.affiliation: Department of Biopharmaceutics, School of Pharmacy, No. 103 of Wenhua Road, Shenyang 110016, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.forename: Jin
authors.initials: J
authors.lastname: Sun
authors.forename: Wenping
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Sui
authors.forename: Zhongtian
authors.initials: Z
authors.lastname: Yan
authors.forename: Zhonggui
authors.initials: Z
authors.lastname: He
mesh_terms: D000068196:Albumin-Bound Paclitaxel; D000418:Albumins / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000068196:Albumin-Bound Paclitaxel; D000418:Albumins; D017239:Paclitaxel