Enhanced transdermal delivery of loratadine from the EVA matrix.
Various enhancers, such as fatty acids (saturated, unsaturated), glycerides, propylene glycols, and non-ionic surfactants, have been incorporated in the loratadine-EVA matrix to increase the rate of skin permeation of loratadine from an EVA matrix. The enhancing effects of these enhancers on the skin permeation of loratadine were evaluated using a modified Keshary-Chien cell fitted with intact excised rat skin. The penetration enhancers showed a higher flux, probably due to the enhancing effect on the skin barrier, the stratum corneum. Among the enhancers used, such as the fatty acids, glycols, propylene glycols, and non-ionic surfactants, linoleic acid showed the best enhancement. For the enhanced transdermal delivery of loratadine, application of an EVA matrix containing a permeation enhancer might be useful in the development of a transdermal drug delivery system.
Cho
Cheong-Weon
CW
Chungnam National University, Daejeon, South Korea.
Choi
Jun-Shik
JS
Kim
Seong-Jin
SJ
Shin
Sang-Chul
SC
D000279:Administration, Cutaneous; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D004347:Drug Interactions; D005989:Glycerides / Q000737:chemistry; D019787:Linoleic Acid / Q000737:chemistry / Q000494:pharmacology*; D017336:Loratadine / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D011145:Polyvinyls / Q000737:chemistry; D019946:Propylene Glycol / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption / Q000187:drug effects*
D018926:Anti-Allergic Agents; D005989:Glycerides; D011145:Polyvinyls; C016438:ethylenevinylacetate copolymer; D019946:Propylene Glycol; D017336:Loratadine; D019787:Linoleic Acid