title: Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the nucleus raphe magnus to participate in pain modulation.
abstract: Hypothalamic paraventricular nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion. AVP is the most important bioactive substance in PVN regulating pain process. Our previous study has pointed that pain stimulation induced AVP increase in the nucleus raphe magnus (NRM), which plays a role in pain modulation. The present study was designed to investigate the source of AVP in the rat NRM during pain process using the methods of nucleus push-pull perfusion and radioimmunoassay. The results showed that pain stimulation increased the AVP concentration in the NRM perfusion liquid, PVN cauterization inhibited the role that pain stimulation induced the increase of AVP concentration in the NRM perfusion liquid, and PVN microinjection of L-glutamate sodium, which excited the PVN neurons, could increase the AVP concentration in the NRM perfusion liquid. The data suggested that AVP in the PVN might be transferred to the NRM to participate in pain modulation.
authors.affiliation: State Key Laboratory of New Technology for Pharmaceuticals, Jiangsu Provincial Institute for Novel Pharmaceuticals at Taizhou, Yangtze River Pharmaceutical Group, 1 Yangtze River South Road, Taizhou, Jiangsu, China. yj6676@yahoo.com
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Huifeng
authors.initials: H
authors.lastname: Yuan
authors.forename: Wenyan
authors.initials: W
authors.lastname: Liu
authors.forename: Chaoyou
authors.initials: C
authors.lastname: Song
authors.forename: Hongtao
authors.initials: H
authors.lastname: Xu
authors.forename: Gen
authors.initials: G
authors.lastname: Wang
authors.forename: Cai
authors.initials: C
authors.lastname: Song
authors.forename: Na
authors.initials: N
authors.lastname: Ni
authors.forename: Daiwei
authors.initials: D
authors.lastname: Yang
authors.forename: Baocheng
authors.initials: B
authors.lastname: Lin
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology*; D002425:Cautery; D018698:Glutamic Acid / Q000494:pharmacology; D008297:Male; D010146:Pain / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism* / Q000601:surgery; D010477:Perfusion; D011903:Raphe Nuclei / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001127:Arginine Vasopressin; D018698:Glutamic Acid