title: Differential associations between brain 5-HT(1A) receptor binding and response to pain versus touch.
abstract: We studied whether brain serotonin 5-HT(1A) receptor availability is associated with response to noxious heat versus tactile stimuli, and short-term memory for heat pain. Psychophysical performance was assessed in 16 healthy subjects who had participated in a positron emission tomography study using [carbonyl-11C]WAY-100635 ligand for the assessment of 5-HT(1A) receptor binding potential (BP (ND)). Signal detection theory was applied to allow separate analysis of the subject's sensory-discriminative capacity (sensory factor) and the attitude toward reporting a sensation (response criterion; non-sensory factor). Subject's response criterion for heat pain was inversely correlated with 5-HT(1A) BP (ND) in the dorsal raphe, middle temporal gyrus, orbitofrontal cortex and posterior cingulum, whereas the subject's discriminative capacity for touch was inversely correlated with 5-HT(1A) BP (ND) in the cingulum, inferior temporal gyrus, and medial prefrontal cortex. Certainty ratings of the responses, but not hit rates, in the pain memory task were correlated with 5-HT(1A) BP (ND) in the dorsal raphe.
authors.affiliation: Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, Turku 20520, Finland Ilkka.Martikainen@utu.fi
authors.forename: Ilkka K
authors.initials: IK
authors.lastname: Martikainen
authors.forename: Jussi
authors.initials: J
authors.lastname: Hirvonen
authors.forename: Ullamari
authors.initials: U
authors.lastname: Pesonen
authors.forename: Nora
authors.initials: N
authors.lastname: Hagelberg
authors.forename: Heikki
authors.initials: H
authors.lastname: Laurikainen
authors.forename: Heikki
authors.initials: H
authors.lastname: Tuikkala
authors.forename: Jaana
authors.initials: J
authors.lastname: Kajander
authors.forename: Kjell
authors.initials: K
authors.lastname: Någren
authors.forename: Jarmo
authors.initials: J
authors.lastname: Hietala
authors.forename: Antti
authors.initials: A
authors.lastname: Pertovaara
mesh_terms: D000328:Adult; D001667:Binding, Competitive / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D017288:Pain Threshold / Q000502:physiology; D010812:Physical Stimulation; D010879:Piperazines / Q000378:metabolism; D049268:Positron-Emission Tomography; D011601:Psychophysics / Q000379:methods; D011725:Pyridines / Q000378:metabolism; D011869:Radioligand Assay; D011903:Raphe Nuclei / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000378:metabolism; D017603:Signal Detection, Psychological / Q000502:physiology; D014110:Touch / Q000502:physiology*
chemical_list: D010879:Piperazines; D011725:Pyridines; D012702:Serotonin Antagonists; D044282:Receptor, Serotonin, 5-HT1A; D012701:Serotonin; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide