Total synthesis and analgesic activity of 6-fluoroindan-1-acetic acid and its 3-oxo derivative.
6-Fluoro-3-oxo-indan-1-acetic acid (5) and 6-fluoroindan-1-acetic acid (6) were conveniently synthesised from 3-fluorobenzaldehyde in four and five steps, respectively. The structures of these new compounds and two other intermediates, 3-fluorobenzylidine-bis-acetoacetate (2) and 3-fluoro-beta-phenyl glutaric acid (3) were elucidated by spectroscopic means, notably, HRMS, 1D and 2D NMR. The analgesic activity of compounds 5 and 6 were assessed by the acetic acid induced writhing in Swiss albino mice.
Yasmin
Hasina
H
Department of Pharmacy, State University of Bangladesh, Dhaka-1209, Bangladesh.
Das
Sharmistha
S
Nahar
Lutfun
L
Masud
M Mehedi
MM
Rahman
M Shafikur
MS
Roy
Suvash C
SC
Rahman
M Mukhlesur
MM
Gibbons
Simon
S
Kundu
Joydeb K
JK
Datta
Bidyut K
BK
Bachar
Sitesh C
SC
Chowdhury
A K Azad
AK
Sarker
Satyajit D
SD
D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D019342:Acetic Acid / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001547:Benzaldehydes / Q000737:chemistry; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy
C547091:6-fluoroindan-1-acetic acid; D000085:Acetates; D000700:Analgesics; D001547:Benzaldehydes; D007189:Indans; D019342:Acetic Acid; C032175:benzaldehyde