Frontal and cingulate gray matter volume reduction in heroin dependence: optimized voxel-based morphometry.
OBJECTIVE
Repeated exposure to heroin, a typical opiate, causes neuronal adaptation and may result in anatomical changes in specific brain regions, particularly the frontal and limbic cortices. The volume changes of gray matter (GM) of these brain regions, however, have not been identified in heroin addiction.


METHODS
Using structural magnetic resonance imaging and an optimized voxel-based morphometry approach, the GM volume difference between 15 Chinese heroin-dependent and 15 healthy subjects was tested.


RESULTS
Compared to healthy subjects, the heroin-dependent subjects had reduced GM volume in the right prefrontal cortex, left supplementary motor cortex and bilateral cingulate cortices.


CONCLUSIONS
Frontal and cingulate atrophy may be involved in the neuropathology of heroin dependence.
Liu
Haihong
H
Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Hao
Yihui
Y
Kaneko
Yoshio
Y
Ouyang
Xuan
X
Zhang
Yan
Y
Xu
Lin
L
Xue
Zhimin
Z
Liu
Zhening
Z
D000293:Adolescent; D000328:Adult; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000473:pathology*; D006556:Heroin Dependence / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology; D017397:Prefrontal Cortex / Q000473:pathology*