title: Preparation, characterization and antifungal properties of 2-(alpha-arylamino phosphonate)-chitosan.
abstract: In this paper, 20 kinds of different 2-(alpha-arylamino phosphonate)-chitosan (2-alpha-AAPCS) were prepared by different Schiff bases of chitosan (CS) reacted with di-alkyl phosphite in benzene solution. The structures of the derivatives (2-alpha-AAPCS) were characterized by FT-IR spectroscopy and elemental analysis. In addition, the antifungal activities of the derivatives against four kinds of fungi were evaluated in the experiment. The results indicated that all the prepared 2-alpha-AAPCS had a significant inhibiting effect on the investigated fungi when the derivatives concentration ranged from 50 to 500microgmL(-1). Furthermore, the antifungal activities of the derivatives increased with increasing the molecular weight and concentration. And the antifungal activities of the derivatives were affected by their dimensional effect and charge density. Besides, the rule and mechanism of the antifungal activities of them were discussed in this paper.
authors.affiliation: Institute of Sciences, Inner Mongolia Agricultural University, Huhhot 010018, China.
authors.forename: Zhimei
authors.initials: Z
authors.lastname: Zhong
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Li
authors.forename: Ronge
authors.initials: R
authors.lastname: Xing
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Chen
authors.forename: Song
authors.initials: S
authors.lastname: Liu
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D048271:Chitosan / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004602:Elements; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000935:Antifungal Agents; D004602:Elements; D063065:Organophosphonates; D048271:Chitosan