Prognostic value of immature platelet fraction and plasma thrombopoietin in disseminated intravascular coagulation.
Although platelet count is a good parameter for the diagnosis of disseminated intravascular coagulation (DIC), a single measurement of platelet is not enough to reflect the ongoing platelet consumption because of compensatory synthesis of circulating platelet number. Increased thrombopoiesis owing to peripheral destruction is expected in patients with DIC. Reticulated platelet, measured as immature platelet fraction (IPF), and plasma thrombopoietin (TPO) are markers of platelet production. We investigated the potential usefulness of circulating IPF and TPO in 222 patients suspected of having DIC. Both IPF and TPO levels were significantly increased in overt DIC patients and well correlated with DIC score. IPF also correlated with fibrin-related marker such as fibrinogen degradation product and D-dimer. Both IPF and TPO showed better mortality prediction than platelet count with the multivariate logistic regression and Kaplan-Meier survival analysis. These results suggest that IPF and TPO are new potential candidates to detect the severity of DIC and to predict DIC mortality.
Hong
Ki Ho
KH
Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
Kim
Hyun Kyung
HK
Kim
Ji-Eun
JE
Jung
Jae Seol
JS
Han
Kyou-Sup
KS
Cho
Han-Ik
HI
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000648:ultrastructure*; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000150:complications / Q000401:mortality; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D034061:Thrombopoiesis; D013926:Thrombopoietin / Q000097:blood*
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D013926:Thrombopoietin