Use of the aromatase inhibitor letrozole to treat male infertility.
OBJECTIVE
Report the case of induction of spermatogenesis with the aromatase inhibitor letrozole.


METHODS
Case report.


METHODS
University Infertility center.


METHODS
A 31-year-old man with primary infertility, normal volume azoospermia, normal follicle stimulating hormone (FSH) levels and pattern of nonobstructive azoospermia (NOA) on a testicular biopsy.


METHODS
The patient was given the aromatase inhibitor letrozole for 4 months and had repeated FSH, testosterone, LH levels, semen analyses, and finally a testicular biopsy.


METHODS
Results of a testis biopsy.


RESULTS
Testis biopsy showed normal spermatogenesis following 4 months of letrozole therapy.


CONCLUSIONS
This is the first case report on the use of letrozole to treat male infertility and the first case report on the induction of spermatogenesis in a man with NOA using any aromatase inhibitor.
Patry
Geneviève
G
Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. kochman@hadassah.org.il
Jarvi
Keith
K
Grober
Ethan D
ED
Lo
Kirk C
KC
D000328:Adult; D047072:Aromatase Inhibitors / Q000008:administration & dosage*; D053713:Azoospermia / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D000077289:Letrozole; D008297:Male; D009570:Nitriles / Q000008:administration & dosage*; D013091:Spermatogenesis / Q000187:drug effects*; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*
D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole