Comparative experimental pharmacokinetics of benzimidazole derivatives.
Comparative study of experimental kinetics of distribution of benzimidazole derivatives (bemithyl, etomerzole, and thietazole) in organs and tissues was carried out after single and course treatment. The drugs intensely passed into organs and tissues from the blood after treatment by all protocols. Specific features of drug distribution were detected; for example, splenic tissue selectively accumulated thietazole during course treatment.
Sergeeva
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SA
Research Center of Bioactive Substances Safety, Staraya Kupavna, Moscow Region, Russia. nauka@materiamedica.ru
Gulyaeva
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D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics; D001562:Benzimidazoles / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics*; D002849:Chromatography, Gas; D051381:Rats; D014018:Tissue Distribution
D000975:Antioxidants; D001562:Benzimidazoles; C049825:bemethyl