A single bicontinuous cubic phase induced by fusion peptides.
We report a bicontinuous cubic phase forming in the presence of the Influenza HA fusion peptide in coarse grained molecular dynamics simulations. Starting from a random mixture of DOPE, water, and fusion peptides, we observe spontaneous formation of a stable bicontinuous phase. Unlike all previously reported bicontinuous cubic phases the one formed in our simulations is a single phase in the sense that there are no multiple isolated compartments of water or lipid.
Fuhrmans
Marc
M
Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Knecht
Volker
V
Marrink
Siewert J
SJ
D003198:Computer Simulation; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000737:chemistry*; D008958:Models, Molecular; D009975:Orthomyxoviridae / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D044367:Phase Transition; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
C410262:1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D010455:Peptides; D010714:Phosphatidylethanolamines; D014867:Water