title: Benzothiazines in synthesis. A formal total synthesis of pseudopteroxazole.
abstract: A formal total synthesis of the antitubercular natural product was accomplished. This work was undertaken to address certain stereochemical problems in our initial synthesis. By using an ester group as a surrogate for a methyl group, we were able to intercept a key intermediate in our first synthesis with better selectivity and greater convergence than had previously been the case.
authors.affiliation: Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA. harmatam@missouri.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Harmata
authors.forename: Zhengxin
authors.initials: Z
authors.lastname: Cai
authors.forename: Yugang
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000995:Antitubercular Agents; D001685:Biological Factors; D004224:Diterpenes; D010080:Oxazoles; D013843:Thiazines; C433836:pseudopteroxazole