Effect of silica gel on the cohesion, properties and biological performance of brushite cement.
The cohesion of calcium phosphate cements can be improved by the addition of substances to either the solid or liquid phase during the setting reaction. This study reports the effect of silica gel on brushite cement cohesion. The cement was prepared using a mixture of beta-tricalcium phosphate (beta-TCP) and monocalcium phosphate monohydrate as the solid phase, while the liquid phase comprised carboxylic acids silica gel. This cement presents a shorter final setting time (FST), better cohesion and higher amount of unreacted beta-TCP than the cement prepared without silica gel. Furthermore, in vivo experiments using rabbits as an animal model showed that after 8 weeks of implantation cements modified with silica gel showed a similar new bone formation volume and more remaining graft in comparison with unmodified cements. Thus, the silica gel could be efficiently applied to reduce cement disintegration and to decrease the resorption rate of brushite cements.
Alkhraisat
Mohammad Hamdan
MH
Departamento de Química-Física II, Facultad de Farmacia, UCM, Plaza: Ramon y Cajal, sn, 28040 Madrid, Spain. mkhresat@farm.ucm.es
Rueda
Carmen
C
Jerez
Luis Blanco
LB
Tamimi Mariño
Faleh
F
Torres
Jesus
J
Gbureck
Uwe
U
Lopez Cabarcos
Enrique
E
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry*; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D005260:Female; D005782:Gels / Q000737:chemistry*; D007249:Inflammation; D008264:Macrophages / Q000378:metabolism; D008422:Materials Testing; D011817:Rabbits; D012822:Silicon Dioxide / Q000737:chemistry*; D013997:Time Factors
D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D002264:Carboxylic Acids; D005782:Gels; C485817:beta-tricalcium phosphate; D012822:Silicon Dioxide; C494366:calcium phosphate, dibasic, dihydrate