title: [Physiopathological mechanism of hot flushes-perspiration induced by androgen deprivation in prostate carcinoma].
abstract: Hot flushes and perspiration are common problems during androgen deprivation therapy for prostate carcinoma, and largely contribute to worsen patient quality of life. Different hypotheses have been proposed to explain the underlying physiopathological mechanisms, though all are very complex, basically because of the multiple causal factors involved. The present review offers a pondered and updated perspective of the origin of hot flushes-perspiration in such patients. Negative feedback of the plasma sexual hormones upon the hypothalamic secretion of noradrenalin and serotonin appears to be the main cause. Likewise, the direct action of such mechanisms upon the LH-RH producing hypothalamic center located close to the thermoregulatory center, together with shortening of the thermoneutral interval, would also play a role. Improved understanding of the causal mechanism may help improve the treatment of such symptoms.
authors.affiliation: Servicio de Radioterapia, Complejo Hospitalario Universitario de Albacete (CHUA), España. santiagov06@gmail.com
authors.forename: Santiago
authors.initials: S
authors.lastname: Vilar Gónzalez
authors.forename: Francesc
authors.initials: F
authors.lastname: Montañá Puig
authors.forename: Ma Victoria
authors.initials: MV
authors.lastname: Villas Sánchez
authors.forename: Ma del Mar
authors.initials: Mdel M
authors.lastname: Sevillano Capellán
authors.forename: Manuel
authors.initials: M
authors.lastname: Aguayo Martos
authors.forename: Sebastiá
authors.initials: S
authors.lastname: Sabater Martí
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects*; D019584:Hot Flashes / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009919:Orchiectomy / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000503:physiopathology* / Q000628:therapy*; D013546:Sweating
chemical_list: D000726:Androgen Antagonists