Tracking the dynamics of salmonella specific T cell responses.
Over the last decade, significant advances have been made in the methodology for studying immune responses in vivo. It is now possible to follow almost every aspect of pathogen-specific immunity using in vivo models that incorporate physiological infectious doses and natural routes of infection. This new ability to study immunity in a relevant physiological context will greatly expand our understanding of the dynamic interplay between host and pathogen. Visualizing the resolution of primary infection and the development of long-term immunological memory should also aid the development of new vaccines and therapeutics for infectious diseases. In this review, we will describe the application of in vivo visualization technology to Salmonella infection, describe our current understanding of Salmonella-specific immunity, and discuss some unanswered questions that remain in this model.
Moon
James J
JJ
Department of Microbiology, Center for Immunology, University of Minnesota Medical, Minneapolis, MN 55455, USA.
McSorley
Stephen J
SJ
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D012475:Salmonella / Q000145:classification / Q000276:immunology / Q000472:pathogenicity; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000276:immunology / Q000472:pathogenicity; D013601:T-Lymphocytes / Q000276:immunology*; D014435:Typhoid Fever / Q000276:immunology* / Q000382:microbiology