Chitosan-based systems for the delivery of vaccine antigens.
This review discusses the current status of chitosan and its derivatives as adjuvants and delivery systems in vaccine delivery, and their future possibilities and challenges. After a brief introduction to adjuvants and delivery systems, chitosan will be described in detail in regard to vaccine formulation. Applications of chitosan and its derivatives will be reviewed and their proposed mechanisms in the enhancement of immune responses will be discussed.
Arca
H Ciğdem
HC
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey. cigdemarca@gmail.com
Günbeyaz
Merve
M
Senel
Sevda
S
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000494:pharmacology; D000941:Antigens / Q000276:immunology*; D048271:Chitosan / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D014612:Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000941:Antigens; D014612:Vaccines; D048271:Chitosan