title: Seasonal variation in blood concentrations of interleukin-6, adrenocorticotrophic hormone, metabolites of catecholamine and cortisol in healthy volunteers.
abstract: We investigated seasonal changes in blood concentrations of interleukin-6 (IL-6), adrenocorticotrophic hormone (ACTH), metabolites of catecholamine (VMA, HVA, and 5-HIAA) and cortisol in humans. Eight volunteers were investigated at four times during the year (February, May, August and October) at latitude 35 degrees N. The mean ambient temperature at the collection periods was higher in the order of summer > autumn approximately spring > winter. Changes in mood were also monitored by a profile of mood states (POMS) questionnaire. The concentration of IL-6 was significantly higher in winter and summer than in spring and autumn. The concentrations of ACTH, HVA and VMA were significantly higher in summer. No seasonal variation was detected in cortisol. There were significant differences among the seasons in subscale tension and anger in the POMS questionnaire; the tension subscale showed significant differences between spring and autumn, with a higher score in spring. The results demonstrate that Il-6, ACTH, HVA and VMA exhibit statistically significant seasonal rhythms, which might have important diagnostic and therapeutic implications.
authors.affiliation: Department of Physiology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan. dkanikowska@hotmail.com
authors.forename: Dominika
authors.initials: D
authors.lastname: Kanikowska
authors.forename: Junichi
authors.initials: J
authors.lastname: Sugenoya
authors.forename: Maki
authors.initials: M
authors.lastname: Sato
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Yoko
authors.initials: Y
authors.lastname: Inukai
authors.forename: Naoki
authors.initials: N
authors.lastname: Nishimura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwase
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D002395:Catecholamines / Q000097:blood*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D012016:Reference Values; D012621:Seasons; D055815:Young Adult
chemical_list: D002395:Catecholamines; D015850:Interleukin-6; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone