title: Cells and prions: a license to replicate.
abstract: Prion diseases are neurodegenerative, infectious disorders characterized by the aggregation of a misfolded isoform of the cellular prion protein (PrP(C)). The infectious agent - termed prion - is mainly composed of misfolded PrP(Sc). In addition to the central nervous system prions can colonize secondary lymphoid organs and inflammatory foci. Follicular dendritic cells are important extraneural sites of prion replication. However, recent data point to a broader range of cell types that can replicate prions. Here, we review the state of the art in regards to peripheral prion replication, neuroinvasion and the determinants of prion replication competence.
authors.affiliation: Department of Pathology, Institutes of Neuropathology, University Hospital Zurich, Switzerland.
authors.forename: Mario
authors.initials: M
authors.lastname: Nuvolone
authors.forename: Adriano
authors.initials: A
authors.lastname: Aguzzi
authors.forename: Mathias
authors.initials: M
authors.lastname: Heikenwalder
mesh_terms: D000818:Animals; D002477:Cells / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D007167:Immunotherapy; D051379:Mice; D017096:Prion Diseases / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D011328:Prions / Q000276:immunology / Q000378:metabolism*
chemical_list: D011328:Prions