DNA breaks as triggers for antigenic variation in African trypanosomes.
The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.
Alsford
Sam
S
London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E7HT, UK.
Horn
David
D
Glover
Lucy
L
D000349:Africa; D000818:Animals; D000940:Antigenic Variation / Q000235:genetics*; D053960:DNA Breaks; D053903:DNA Breaks, Double-Stranded; D014345:Trypanosoma / Q000235:genetics*; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000235:genetics
D014643:Variant Surface Glycoproteins, Trypanosoma