title: Autophagy, immunity, and microbial adaptations.
abstract: Autophagy adjusts cellular biomass and function in response to diverse stimuli, including infection. Autophagy plays specific roles in shaping immune system development, fueling host innate and adaptive immune responses, and directly controlling intracellular microbes as a cell-autonomous innate defense. As an evolutionary counterpoint, intracellular pathogens have evolved to block autophagic microbicidal defense and subvert host autophagic responses for their survival or growth. The ability of eukaryotic pathogens to deploy their own autophagic machinery may also contribute to microbial pathogenesis. Thus, a complex interplay between autophagy and microbial adaptations against autophagy governs the net outcome of host-microbe encounters.
authors.affiliation: Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA. vderetic@salud.unm.edu
authors.forename: Vojo
authors.initials: V
authors.lastname: Deretic
authors.forename: Beth
authors.initials: B
authors.lastname: Levine
mesh_terms: D000818:Animals; D001343:Autophagy; D001419:Bacteria / Q000276:immunology*; D003141:Communicable Diseases / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology; D056890:Eukaryota / Q000276:immunology*; D054884:Host-Pathogen Interactions; D008954:Models, Biological