title: Role of cardiac glycosides in regulation of the growth of retinal tissue explants.
abstract: We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10(-13)M), strophanthin K (10(-13)M) and digoxin (10(-11)M) significantly stimulated explant growth. It was hypothesized that the physiological role of endogenous ouabain is associated with regulation of tissue modeling.
authors.affiliation: Department of Experimental Pharmacology of V. A. Almazov Federal Heart, Blood and Endocrinology Center, Saint-Petersburg, Russia. evl1112@infran.ru
authors.forename: E V
authors.initials: EV
authors.lastname: Lopatina
authors.forename: A V
authors.initials: AV
authors.lastname: Karetsky
authors.forename: V A
authors.initials: VA
authors.lastname: Penniyaynen
authors.forename: T V
authors.initials: TV
authors.lastname: Vinogradova
mesh_terms: D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002642:Chick Embryo; D002645:Chickens; D004077:Digoxin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D009924:Organ Culture Techniques; D010042:Ouabain / Q000378:metabolism / Q000494:pharmacology; D012160:Retina / Q000166:cytology / Q000187:drug effects*; D013328:Strophanthins / Q000494:pharmacology
chemical_list: D002301:Cardiac Glycosides; D004791:Enzyme Inhibitors; D013328:Strophanthins; D010042:Ouabain; D004077:Digoxin; C029082:strophanthin K