Gallbladder function and dynamics of bile flow in asymptomatic gallstone disease.
OBJECTIVE
To investigate the effects of gallbladder stones on motor functions of the gallbladder and the dynamics of bile flow in asymptomatic gallstone disease.


METHODS
Quantitative hepatobiliary scintigraphy was performed to detect the parameters of gallbladder motor function [gallbladder ejection fraction (GBEF), gallbladder visualization time (GBVT), gallbladder time to peak activity (GBT(max)), gallbladder half emptying time (GBT(1/2)), and transit time of bile to duodenum (TTBD)] in 24 patients with asymptomatic cholelithiasis who were diagnosed incidentally during routine abdominal ultrasonographic examination and 20 healthy subjects with normal gallbladder.


RESULTS
Even though there was no significant difference in the clinical and laboratory parameters between the patient and control groups, all parameters of gallbladder function except TTBD were found to differ significantly between the two groups. GBEF in the patient group was decreased (P = 0.000) and GBVT, GBT(max), GBT(1/2) in the patient group were longer (P = 0.000, P = 0.015, P = 0.001, respectively).


CONCLUSIONS
Our results showed that even if there were not any clinical and laboratory findings, gallbladder filling and emptying could be impaired in patients with gallstone disease.
Cerçi
Sevim Süreyya
SS
Department of Nuclear Medicine, University of Suleyman Demirel Hospital, Isparta, Turkey. sureyyacerci@hotmail.com
Ozbek
Feride Meltem
FM
Cerçi
Celal
C
Baykal
Bahattin
B
Eroğlu
Hasan Erol
HE
Baykal
Zeynep
Z
Yildiz
Mustafa
M
Sağlam
Semahat
S
Yeşildağ
Ahmet
A
D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism*; D002769:Cholelithiasis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000502:physiology*; D016473:Gallbladder Emptying / Q000502:physiology*; D042882:Gallstones / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography