title: A new efficient mixture screening design for optimization of media.
abstract: Screening ingredients for the optimization of media is an important first step to reduce the many potential ingredients down to the vital few components. In this study, we propose a new method of screening for mixture experiments called the centroid screening design. Comparison of the proposed design with Plackett-Burman, fractional factorial, simplex lattice design, and modified mixture design shows that the centroid screening design is the most efficient of all the designs in terms of the small number of experimental runs needed and for detecting high-order interaction among ingredients.
authors.affiliation: Department of Mathematics, Dowling College, Oakdale, NY 11769, USA.
authors.forename: Fred
authors.initials: F
authors.lastname: Rispoli
authors.forename: Vishal
authors.initials: V
authors.lastname: Shah
mesh_terms: D003470:Culture Media / Q000737:chemistry*; D005285:Fermentation; D008828:Microbiological Techniques / Q000379:methods*; D012107:Research Design
chemical_list: D003470:Culture Media