title: The circulating concentration and ratio of total and high molecular weight adiponectin in post-menopausal women with and without osteoporosis and its association with body mass index and biochemical markers of bone metabolism.
abstract: OBJECTIVE
  There is increasing evidence suggesting that adiponectin plays a role in the regulation of bone metabolism.
  
  
  METHODS
  This was a cross-sectional study of 34 post-menopausal women with and 37 without osteoporosis. All subjects had body mass index (BMI), bone mineral density (BMD), total-, high molecular weight (HMW)-adiponectin and their ratio, osteoprotegerin (OPG), a marker of bone resorption (betaCTX) and formation (P1NP) measured.
  
  
  RESULTS
  We observed a positive correlation between BMI and BMD (r=0.44, p<0.001). When normalised for BMI, total-, HMW-adiponectin concentrations and HMW/total-adiponectin ratio were significantly lower in obese compared to lean subjects but there was no difference between those with or without osteoporosis. There were significant negative correlations between HMW/total-adiponectin ratio and BMI (r=-0.27, p=0.030) and with OPG (r=-0.44, p<0.001).
  
  
  CONCLUSIONS
  Our data suggests that there is no significant difference in the circulating concentration of fasting early morning total- or HMW-adiponectin in post-menopausal women with or without osteoporosis. The correlation between HMW/total-adiponectin ratio and OPG may indicate that adiponectin could influence bone metabolism by altering osteoblast production of OPG thereby affecting osteoclasts mediated bone resorption.
authors.affiliation: The Unit of Clinical Chemistry, School of Clinical Sciences, Faculty of Medicine, University of Liverpool, Liverpool L69 3GA, UK. ravsodi@yahoo.com
authors.forename: R
authors.initials: R
authors.lastname: Sodi
authors.forename: M J
authors.initials: MJ
authors.lastname: Hazell
authors.forename: B H
authors.initials: BH
authors.lastname: Durham
authors.forename: C
authors.initials: C
authors.lastname: Rees
authors.forename: L R
authors.initials: LR
authors.lastname: Ranganath
authors.forename: W D
authors.initials: WD
authors.lastname: Fraser
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000097:blood; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D008970:Molecular Weight; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000378:metabolism; D053244:Osteoprotegerin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D017698:Postmenopause / Q000097:blood*; D011347:Procollagen / Q000097:blood
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D024042:Collagen Type I; D053244:Osteoprotegerin; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide