title: CNS regeneration: only on one condition.
abstract: The mammalian CNS is usually not capable of regeneration. However, conditioning dorsal root ganglion neurons by first lesioning their peripheral axons allows for regeneration of their central axons later on within the spinal cord. New work shows that, even if the sequence of lesioning is reversed, regeneration through the CNS lesion can rapidly occur under certain conditions.
authors.affiliation: Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. jxs10@po.cwru.edu
authors.forename: Jerry
authors.initials: J
authors.lastname: Silver
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D002490:Central Nervous System / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D005727:Ganglia, Spinal / Q000502:physiology* / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats; D011984:Sensory Receptor Cells / Q000502:physiology* / Q000648:ultrastructure