Study of drug transport between the blood and lymph in the predominant direction.
Our method for evaluating the time course and intensity of antibiotics and other drugs transport in the predominant direction between the blood and lymph in humans promotes a more objective evaluation of drug circulation mechanisms, which is essential for determining the time of their repeated administration and route of administration. Calculation of the lymph/blood difference coefficient, based on parallel repeated measurements of the drug concentration in the lymph and blood, and of the lymph/blood coefficient provides complete data on the direction and time course of drug transport between the lymph and blood in the predominant direction.
Petrovich
Yu A
YA
Moscow Medical Stomatological Institute, Russia.
Yarema
I V
IV
Kichenko
S M
SM
Urtaev
B M
BM
D000667:Ampicillin / Q000097:blood / Q000493:pharmacokinetics; D001692:Biological Transport / Q000502:physiology*; D006801:Humans; D007612:Kanamycin / Q000097:blood / Q000493:pharmacokinetics; D008196:Lymph / Q000378:metabolism*; D009827:Oleandomycin / Q000097:blood / Q000493:pharmacokinetics; D010538:Peritonitis / Q000188:drug therapy; D004364:Pharmaceutical Preparations / Q000097:blood*; D013752:Tetracycline / Q000097:blood / Q000493:pharmacokinetics
D004364:Pharmaceutical Preparations; D007612:Kanamycin; D000667:Ampicillin; C011354:sigmamycin; D013752:Tetracycline; D009827:Oleandomycin