title: Proton spot scanning radiotherapy of spontaneous canine tumors.
abstract: Thirty dogs with spontaneous tumors were irradiated with proton therapy using a novel spot scanning technique to evaluate the safety and efficacy of the system, and to study the acute and late radiation reactions. Nasal tumors, soft tissue sarcomas, and miscellaneous tumors of the head were treated with a median total dose of 52.5 Gy given in 3.5 Gy fractions. Acute effects, late effects, tumor response, and outcome were analyzed. No unexpected radiation reactions were seen, however two dogs did develop in-field osteosarcoma, and one dog developed in-field bone necrosis. Complete response to therapy was seen in 40% (12/30), partial response in 47% (14/30), and no response in 13% (4/30). Median survival for all dogs was 385 days (range of 14-4583 days). Dogs with nasal cavity tumors had a median survival of 385 days (range of 131-1851 days) and dogs with soft tissue sarcomas had a median survival time of 612 days (range of 65-4588 days). Treatment outcome was similar to historical controls. This new proton spot scanning technique proved to be safe and reliable.
authors.affiliation: Egg 643, 9055 Buehler, Switzerland.
authors.forename: Simona
authors.initials: S
authors.lastname: Mayer-Stankeová
authors.forename: Janean
authors.initials: J
authors.lastname: Fidel
authors.forename: Melanie C
authors.initials: MC
authors.lastname: Wergin
authors.forename: Beat
authors.initials: B
authors.lastname: Hauser
authors.forename: Andrea
authors.initials: A
authors.lastname: Sumová
authors.forename: Gudrun
authors.initials: G
authors.lastname: Goitein
authors.forename: Eros
authors.initials: E
authors.lastname: Pedroni
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Lomax
authors.forename: Uwe
authors.initials: U
authors.lastname: Schneider
authors.forename: Hans
authors.initials: H
authors.lastname: Blattmann
authors.forename: Barbara
authors.initials: B
authors.lastname: Kaser-Hotz
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000532:radiotherapy*; D004285:Dogs; D009369:Neoplasms / Q000532:radiotherapy / Q000662:veterinary*; D011522:Protons; D011832:Radiation Injuries / Q000662:veterinary; D011879:Radiotherapy Dosage / Q000662:veterinary; D020266:Radiotherapy, Conformal / Q000662:veterinary
chemical_list: D011522:Protons