title: Recent advances in synthesis of PAR ligands as therapeutic strategy for inflammatory diseases.
abstract: Several studies have been published on discovering involvement of PARs receptors in a number of disease states, including cancer and inflammation of the cardiovascular, respiratory, musculoskeletal, gastrointestinal and nervous systems. This mini-review will focus on recent advances in the synthesis of PAR ligands highlighting their therapeutic potential in the treatment of various inflammatory diseases.
authors.affiliation: Department of Pharmaceutical and Toxicological Chemistry, University of Naples Federico II, via D. Montesano 49, -80131 Naples, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Severino
authors.forename: V
authors.initials: V
authors.lastname: Santagada
authors.forename: E
authors.initials: E
authors.lastname: Perissutti
authors.forename: F
authors.initials: F
authors.lastname: Fiorino
authors.forename: F
authors.initials: F
authors.lastname: Frecentese
authors.forename: F
authors.initials: F
authors.lastname: De Angelis
authors.forename: A
authors.initials: A
authors.lastname: Esposito
authors.forename: G
authors.initials: G
authors.lastname: Caliendo
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism*; D008024:Ligands; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D044462:Receptors, Proteinase-Activated / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D006571:Heterocyclic Compounds; D008024:Ligands; D009930:Organic Chemicals; D044462:Receptors, Proteinase-Activated