title: Diffusion tensor imaging (DTI) of the brain in moving subjects: application to in-utero fetal and ex-utero studies.
abstract: We present a methodology to achieve 3D high-resolution diffusion tensor image reconstruction of the brain in moving subjects. The source data is diffusion-sensitized single-shot echo-planar images. After continuous scanning to acquire a repeated series of parallel slices with 15 diffusion directions, image registration is used to realign the images to correct for subject motion. Once aligned, the diffusion images are treated as irregularly-sampled data where each voxel is associated with an appropriately rotated diffusion direction. This data is used to estimate the diffusion tensor on a regular grid. The method has been tested on data acquired at 1.5T from adults who deliberately moved and from eight fetuses imaged in utero. Maps of apparent diffusion coefficient (ADC) were reliably produced in all cases and promising performance was achieved for fractional anisotropy maps. Results from normal fetal brains were found to be consistent with published data from premature infants of similar gestational age.
authors.affiliation: Imaging Science Department, MRC Clinical Sciences Centre, Imperial College Hammersmith Hospital Campus, London, UK.
authors.forename: Shuzhou
authors.initials: S
authors.lastname: Jiang
authors.forename: Hui
authors.initials: H
authors.lastname: Xue
authors.forename: Serena
authors.initials: S
authors.lastname: Counsell
authors.forename: Mustafa
authors.initials: M
authors.lastname: Anjari
authors.forename: Joanna
authors.initials: J
authors.lastname: Allsop
authors.forename: Mary
authors.initials: M
authors.lastname: Rutherford
authors.forename: Daniel
authors.initials: D
authors.lastname: Rueckert
authors.forename: Joseph V
authors.initials: JV
authors.lastname: Hajnal
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology* / Q000196:embryology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007231:Infant, Newborn; D009068:Movement; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique