title: Parecoxib does not suppress thromboxane synthesis in newborn piglets with group B streptococcal sepsis.
abstract: Group B streptococci (GBS) cause fatal sepsis in newborns. Strong activation of thromboxane synthesis is assumed to correlate with severe pulmonary hypertension. In this study we compared the impact of indomethacin versus parecoxib on hemodynamics and outcome and investigated the pharmacological effects on thromboxane synthesis and EP-3 receptor gene expression. Whereas both parecoxib and indometacin reduced expression of thromboxane synthase and EP-3 receptor in infected lung tissue, parecoxib did not suppress urine levels of thromboxane like indometacin. We presume that COX-2 inhibition in GBS sepsis is associated with enhanced thrombogenicity.
authors.affiliation: Children's Hospital, University of Erlangen-Nuernberg, Loschgestr. 15, 91054 Erlangen, Germany.
authors.forename: Stephanie C
authors.initials: SC
authors.lastname: Nögel
authors.forename: Martin
authors.initials: M
authors.lastname: Chada
authors.forename: Ana-Marija
authors.initials: AM
authors.lastname: Schmidt
authors.forename: Stephan
authors.initials: S
authors.lastname: Bosselmann
authors.forename: Michael
authors.initials: M
authors.lastname: Kandler
authors.forename: Horst
authors.initials: H
authors.lastname: Schweer
authors.forename: Bernhard
authors.initials: B
authors.lastname: Watzer
authors.forename: Holm
authors.initials: H
authors.lastname: Schneider
authors.forename: Andre
authors.initials: A
authors.lastname: Gessner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Rascher
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology*; D015232:Dinoprostone / Q000652:urine; D011464:Epoprostenol / Q000378:metabolism / Q000652:urine; D005786:Gene Expression Regulation / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000652:urine; D007555:Isoxazoles / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D010976:Platelet Count; D018078:Receptors, Prostaglandin E / Q000378:metabolism; D018805:Sepsis / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology / Q000652:urine; D013290:Streptococcal Infections / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology / Q000652:urine; D013292:Streptococcus agalactiae; D013552:Swine; D013931:Thromboxanes / Q000096:biosynthesis* / Q000378:metabolism / Q000652:urine
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D007555:Isoxazoles; D018078:Receptors, Prostaglandin E; D013931:Thromboxanes; C409945:parecoxib; D011464:Epoprostenol; D015232:Dinoprostone; D007213:Indomethacin