Intracellular signaling: peripatetic Ras.
Ras proteins traffic between the plasma membrane and endomembranes and signal from the cytosolic face of a variety of organelles. Palmitoylated N-Ras and H-Ras signal from early endosomes. A recent study reports that K-Ras resides on and signals from various types of endosomes, including late endosomes/lysosomes and multivesicular bodies.
Fehrenbacher
Nicole
N
NYU Cancer Institute, 550 First Avenue, New York, NY 10016, USA.
Philips
Mark
M
D011992:Endosomes / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D008954:Models, Biological; D020033:Protein Isoforms / Q000378:metabolism; D021381:Protein Transport; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism*
D020033:Protein Isoforms; D018631:ras Proteins