Screening for Celiac disease in Hodgkin and non-Hodgkin lymphoma patients.
OBJECTIVE
Celiac disease is an abnormal T cell-mediated immune response against dietary gluten in genetically predisposed individuals. The aim of our prospective study was to evaluate the frequency of Celiac disease in patients with lymphoma and to determine the usefulness of the anti-gliadin and anti-endomysial antibodies (EMA) for diagnosis of Celiac disease in this patient group.


METHODS
We studied 119 patients with previously or newly diagnosed non-Hodgkin's lymphoma and 60 patients with Hodgkin's lymphoma who presented at the hematology and medical oncology divisions of Dicle University Hospital in Turkey between December 2002 and January 2006. Serological screening for Celiac disease was performed in all patients by searching for serum anti-gliadin immunoglobulin A and immunoglobulin G, and EMA immunoglobulin A and immunoglobulin G.


RESULTS
In the Hodgkin's lymphoma group, anti-gliadin immunoglobulin A was detected in 9 (15%) patients (3 male, 6 female), and antigliadin immunoglobulin G was detected in 21 (35%) patients (15 male, 6 female). In the non-Hodgkin's lymphoma group, antigliadin immunoglobulin A was detected in 6 (5%) patients (2 M male 4 female), and anti-gliadin immunoglobulin G was detected in 30 (25.2%) patients (18 male, 12 female). EMA immunoglobulin A and immunoglobulin G were not detected in the Hodgkin's lymphoma and non-Hodgkin's lymphoma groups.


CONCLUSIONS
Our report is the first to describe the frequency of Celiac disease in patients with lymphoma in the southeast region of Turkey. In our study, there was no evidence that Celiac disease is a pre-malignant condition for lymphoma. Serological screening for Celiac disease in lymphoma patients does not seem to be necessary.
Cil
Timuçin
T
Division of Medical Oncology, Dicle University, School of Medicine, Diyarbakir, Turkey. drtimcil@dicle.edu.tr
Altintaş
Abdullah
A
Işikdoğan
Abdurrahman
A
Paşa
Semir
S
Bayan
Kadim
K
Batun
Sabri
S
Büyükbayram
Hüseyin
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D005903:Gliadin / Q000097:blood / Q000276:immunology; D006689:Hodgkin Disease / Q000097:blood / Q000453:epidemiology*; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D015994:Incidence; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000453:epidemiology*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin