An investigation of the embryologic development of the fascia used as the basis for pancreaticoduodenal mobilization.
BACKGROUND
The retropancreatic fusion fascia, or fascia of Treitz, is a critical anatomical landmark during retropancreatic mobilization of the pancreatic head and duodenum (the Kocher maneuver).


METHODS
Using semiserial sections from 24 human fetuses of 9-30 weeks gestation, we examined the development of this fascia.


RESULTS
Retroperitoneal fixation of the pancreas occurred at around 10 weeks. Up to 20 weeks, an apparent remnant of the mesoduodenum was attached to the now-distinct renal fascia. Lymphatic vessels and follicles congregated along the ventral aspect of the fusion plane during early development. In 20- to 30-week fetuses, the duodenum began to occupy a definite position and, at the same stage, a candidate for the fascia of Treitz was seen; it was separated from the thick renal fascia by loose connective tissue.


CONCLUSIONS
We hypothesize that mechanical stress during the development and growth of the duodenum causes the transformation of an indistinct remnant of the peritoneum into a distinct fascia. This mechanism is similar to that seen during the development of the renal fascia, in which the developing adrenal cortex and migrating kidney generate stress on a bundle of thin collagen fibers. Therefore, the fascia of Treitz is unlikely to be a simple remnant of the peritoneum. The fascia, if evident during surgery, should be attached to the pancreatic parenchymal side.
Cho
Baik Hwan
BH
Department of Surgery, Faculty of Medicine, Medical School, Chonbuk National University, 634-18 Geumam-dong, Deokjin-gu, Jeonju, 561-712, Republic of Korea. chobh@chonbuk.ac.kr
Kimura
Wataru
W
Song
Chang Ho
CH
Fujimiya
Mineko
M
Murakami
Gen
G
D004386:Duodenum / Q000196:embryology*; D005205:Fascia / Q000196:embryology*; D005865:Gestational Age; D006801:Humans; D007668:Kidney / Q000196:embryology; D010179:Pancreas / Q000196:embryology*; D010537:Peritoneum / Q000196:embryology