title: Chitosan-based systems for the delivery of vaccine antigens.
abstract: This review discusses the current status of chitosan and its derivatives as adjuvants and delivery systems in vaccine delivery, and their future possibilities and challenges. After a brief introduction to adjuvants and delivery systems, chitosan will be described in detail in regard to vaccine formulation. Applications of chitosan and its derivatives will be reviewed and their proposed mechanisms in the enhancement of immune responses will be discussed.
authors.affiliation: Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey. cigdemarca@gmail.com
authors.forename: H Ciğdem
authors.initials: HC
authors.lastname: Arca
authors.forename: Merve
authors.initials: M
authors.lastname: Günbeyaz
authors.forename: Sevda
authors.initials: S
authors.lastname: Senel
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000494:pharmacology; D000941:Antigens / Q000276:immunology*; D048271:Chitosan / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D014612:Vaccines / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D000941:Antigens; D014612:Vaccines; D048271:Chitosan