title: [Venous sinus thrombosis which occurred during treatment of a 15-years old girl with t cell non-Hodgkin lymphoma - case report].
abstract: Venous thrombosis (VT) is a rare condition in childhood, being usually associated with congenital predisposition or acquired risk factors. The incidence of VT among children with cancer is between 1 and 36%. The highest incidence is among children with acute lymphoblastic leukaemia, followed by those with lymphoma and solid tumours. Malignancy and/or chemotherapy complications are considered as triggering factors. We report a case of a 15-year-old girl with non-Hodgkin lymphoma who developed generalized seizures during chemotherapy. Head computed tomography revealed right transverse and sagittal sinus thrombosis. Anticoagulation treatment using heparin as well as thrombolytic treatment with recombinant human tissue plasminogen activator (rhtPA) were introduced. The immediate application of rhtPA resulted in recanalisation of initially involved vessels which led to recovery with no neurological deficits. The reported case of severe venous thrombosis suggests that systemic treatment with rhtPA is effective and safe in children with cerebral venous sinus thrombosis.
authors.affiliation: Klinika Pediatrii, Hematologii i Onkologii Dzieciecej Pomorskiej Akademii Medycznej, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland. emaloney@wp.pl
authors.forename: Eliza
authors.initials: E
authors.lastname: Maloney
authors.forename: Tomasz
authors.initials: T
authors.lastname: Ociepa
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Kamieńska
authors.forename: Karolina
authors.initials: K
authors.lastname: Zielezińska
authors.forename: Błazej
authors.initials: B
authors.lastname: Richter
authors.forename: Tomasz
authors.initials: T
authors.lastname: Urasiński
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy; D011859:Radiography; D012851:Sinus Thrombosis, Intracranial / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D005343:Fibrinolytic Agents; D006493:Heparin; D010959:Tissue Plasminogen Activator