title: Dedifferentiated liposarcoma with rhabdomyoblastic differentiation in an 8-year-old girl.
abstract: The development of a liposarcoma during childhood is extremely rare. We report a case of dedifferentiated liposarcoma arising in the left thigh of an 8-year-old girl. Morphological and immunohistochemical studies revealed occasional rhabdomyoblastic differentiation in the dedifferentiated component. The identical cells were co-mingling with the well-differentiated liposarcoma component. This is the first description of such a case of liposarcoma occurring in a child.
authors.affiliation: Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan. okamotosum@kochi-u.ac.jp
authors.forename: Sumika
authors.initials: S
authors.lastname: Okamoto
authors.forename: Rikuo
authors.initials: R
authors.lastname: Machinami
authors.forename: Taisuke
authors.initials: T
authors.lastname: Tanizawa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Gang-Hong
authors.initials: GH
authors.lastname: Lee
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
mesh_terms: D002454:Cell Differentiation; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008080:Liposarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013848:Thigh / Q000473:pathology
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2