Vitamin C with metabolites reduce oxalate levels compared to ascorbic acid: a preliminary and novel clinical urologic finding.
The incidence and prevalence of kidney stones are notable and are projected to increase over the next decade. Risk factors for kidney stones abound, but a prominent risk factor is hyperoxaluria, which has numerous etiologies, including vitamin C (ascorbic acid) dietary supplement intake. This randomized, double-blind, crossover study examined the effects of two different vitamin C formulations and found that vitamin C with metabolites (Ester-C) significantly reduced urine oxalate levels compared to ascorbic acid. This is a potential novel finding that requires further clinical evaluation.
Moyad
Mark A
MA
University of Michigan Medical Center, Department of Urology, Ann Arbor, MI, USA.
Combs
Maile A
MA
Crowley
David C
DC
Baisley
Joshua E
JE
Sharma
Prachi
P
Vrablic
Angelica S
AS
Evans
Malkanthi
M
D000328:Adult; D001205:Ascorbic Acid / Q000494:pharmacology*; D018592:Cross-Over Studies; D003683:Dehydroascorbic Acid / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006959:Hyperoxaluria / Q000517:prevention & control*; D007669:Kidney Calculi / Q000517:prevention & control*; D008297:Male; D010070:Oxalates / Q000652:urine; D013912:Threonine / Q000494:pharmacology*
D004338:Drug Combinations; D010070:Oxalates; C069207:calcium ascorbate; D013912:Threonine; D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid