The flavonoid quercetin protects and prevents against potassium dichromate-induced systemic peroxidation of lipids and diminution in renal clearance of para-aminohippuric acid and inulin in the rat.
It is well known that exposure to chromium (Cr) can lead to nephrotoxicity. Quercetin is a flavonoid of interest because of its proposed health-promoting effects. The aim of this work was to elucidate the role of quercetin against the nephrotoxicity caused by Cr in rats. Quercetin may have positive effects in combating, or helping to prevent, nephrotoxicity. It was observed that a single dose of potassium dichromate resulted in both an increase of systemic peroxidation of lipids and a decrease of the renal clearance of para-aminohippuric acid and inulin. Our results show that treatment with quercetin protected and prevented against these damaging effects.
Becerra-Torres
Sergio Lucio
SL
Departamento de Fisiología y Farmacología, Centro de Ciencias Basicas, UniversidadAutonoma de Aguascalientes, Aguascalientes, Mexico. luciobecerratorres@hotmail.com
Rodríguez-Vázquez
María Luisa
ML
Medina-Ramírez
Iliana Ernestina
IE
Jaramillo-Juárez
Fernando
F
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D007444:Inulin / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D011192:Potassium Dichromate / Q000633:toxicity*; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D010130:p-Aminohippuric Acid / Q000378:metabolism
D000975:Antioxidants; D007444:Inulin; D011794:Quercetin; D011192:Potassium Dichromate; D010130:p-Aminohippuric Acid