Evaluation of immunotherapy efficiency in mouse CaO-1 ovarian carcinoma treated by vaccines based on dendritic cells.
Injection of dendritic cells, pulsated by tumor lysate or mucin, containing CA 125 antigen, led to a more than 50% inhibition of tumor growth in female CBA mice with transplanted mouse pseudomucinous CaO-1 ovarian carcinoma in comparison with the control. Tumor-associated CA 125 antigen can be used for obtaining dendritic cell vaccines against ovarian malignant tumors. This trend will extend the potentialities of application of antitumor vaccines based on dendritic cells, as clinical use of this technology is limited by the need in patient's tumor material. Mucin, containing Ca 125 antigen, can be isolated from patient's serum or obtained by gene engineering technologies as a recombinant peptide.
Sitdikova
S M
SM
NN Blokhin Russian Research Center for Oncology, the Russian Academy of Medical Sciences, Moscow, Russia. suriasitdikova@yandex.ru
Kiselevskii
M V
MV
Sel'chuk
V Yu
VY
Amandzholov
B S
BS
Kurbatova
E A
EA
Donenko
F V
FV
D000818:Animals; D018394:CA-125 Antigen / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D002277:Carcinoma / Q000628:therapy*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000628:therapy*
D018394:CA-125 Antigen; D019496:Cancer Vaccines