title: Peri-operative adrenocortical response to low-dose (1 microg) ACTH and relation to postoperative complications in patients undergoing elective abdominal surgery.
abstract: BACKGROUND
  To test the hypothesis that reduced responsiveness to adrenocorticotropin (ACTH) stimulation before elective major abdominal surgery is associated with an increased incidence of postoperative complications.
  
  
  METHODS
  A low-dose (1 microg) ACTH test was performed the day before surgery, during the operation, on the first postoperative day, and before discharge from the hospital in 77 patients undergoing major abdominal surgery (age 62 [47;69] yrs [median, quartiles]; 30 female). Thirty-one patients undergoing minor, non-abdominal surgery (mostly inguinal hernia repair) (age 57 [40;66] yrs; 14 female) served as controls with minor surgical stress. A stimulated plasma cortisol concentration >or=500 nmol/l or an increment of >or=200 nmol/l in response to 1 microg ACTH was defined as normal. Scores for surgical stress and comprehensive risk, postoperative complications, and length of hospital stay (LOS) were assessed.
  
  
  RESULTS
  On the day before major abdominal surgery, basal and stimulated plasma cortisol were 242 (165;299) nmol/l and 497 (404;568) nmol/l, respectively. Eighteen (23%) patients had an abnormal ACTH test, and 7 of these (39%) had complications versus 25 (42%) of the 59 patients with normal ACTH tests (P = .992). Surgical stress, comprehensive risk, and intra- and postoperative basal cortisol levels were higher and the response to ACTH stimulation smaller in patients with major abdominal compared to minor surgery. The peri-operative course of ACTH responses was not associated with complications or LOS in abdominal surgery patients.
  
  
  CONCLUSIONS
  In patients scheduled for abdominal surgery, pre-operatively reduced adrenal response to stimulation with 1 microg ACTH is common but not associated with postoperative complications.
authors.affiliation: Department of Intensive Care Medicine, Inselspital, Bern University Hospital, Bern, Switzerland.
authors.forename: Lukas
authors.initials: L
authors.lastname: Brander
authors.forename: Tobias
authors.initials: T
authors.lastname: Haltmeier
authors.forename: Anna
authors.initials: A
authors.lastname: Suter
authors.forename: Peter
authors.initials: P
authors.lastname: Studer
authors.forename: Daniel
authors.initials: D
authors.lastname: Inderbitzin
authors.forename: Daniel
authors.initials: D
authors.lastname: Candinas
authors.forename: Andreas
authors.initials: A
authors.lastname: Vogt
authors.forename: Christoph
authors.initials: C
authors.lastname: Henzen
authors.forename: Jukka
authors.initials: J
authors.lastname: Takala
authors.forename: Stephan M
authors.initials: SM
authors.lastname: Jakob
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D015994:Incidence; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D011183:Postoperative Complications / Q000453:epidemiology*; D012307:Risk Factors
chemical_list: D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone