Gastric hyposecretion in esophageal squamous-cell carcinomas.
Recently, gastric fundic atrophy is reported to be an independent risk factor for esophageal squamous-cell carcinoma (ESCC). The aim of this study is to investigate the acid secretory level in ESCC in a case-control study. From April 2004 to March 2008, 100 consecutive subjects with early ESCC and 100 age- and sex-matched asymptomatic controls were prospectively enrolled. Gastrin-stimulated acid output was assessed by endoscopic gastrin test. Conditional regression analyses were used to adjust for other potential confounders. Multivariate analyses revealed a strong association between profound hypochlorhydria and ESCC with odds ratio (95% confidence interval): 6.0 (1.9-18.4). The association remained significant after adjusting for the effect of gastric atrophy as a covariate. The association became stronger as the ESCC developed more distal site of the esophagus. This study indicates that profound hypochlorhydria is a strong independent risk factor for ESCC even after adjusting for the influence of gastric atrophy.
Iijima
K
K
Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aobaku, Sendai, Miyagi 980-8574, Japan. jiijima@int3.med.tohoku.ac.jp
Koike
T
T
Abe
Y
Y
Yamagishi
H
H
Ara
N
N
Asanuma
K
K
Uno
K
K
Imatani
A
A
Nakaya
N
N
Ohara
S
S
Shimosegawa
T
T
D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000209:etiology* / Q000473:pathology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005757:Gastritis, Atrophic / Q000150:complications*; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D016015:Logistic Models; D008297:Male; D020116:Pepsinogen A / Q000097:blood; D011446:Prospective Studies; D012044:Regression Analysis
D020116:Pepsinogen A