title: Hypertonic stress in the kidney: a necessary evil.
abstract: The interstitium of the renal medulla is hypertonic, imposing deleterious effects on local cells. At the same time, the hypertonicity provides osmotic gradient for water reabsorption and is a local signal for tissue-specific gene expression and differentiation of the renal medulla, which is a critical organ for water homeostasis.
authors.affiliation: Department of Medicine, University of Maryland, Baltimore, MD, USA. mkwon@medicine.umaryland.edu
authors.forename: Min Seong
authors.initials: MS
authors.lastname: Kwon
authors.forename: Sun Woo
authors.initials: SW
authors.lastname: Lim
authors.forename: H Moo
authors.initials: HM
authors.lastname: Kwon
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000502:physiology*; D009997:Osmotic Pressure / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology*