Serum high mobility group box protein 1 as a clinical marker for non-small cell lung cancer.
OBJECTIVE
The role of high mobility group box protein 1 (HMGB1) in non-small cell lung cancer (NSCLC) is unknown. We investigated the contributions of HMGB1 in NSCLC, and analyze the correlation between HMGB1 and clinicopathologic outcomes.


METHODS
A total of 145 patients with diagnosed NSCLC, and 77 patients with diagnosed chronic obstructive pulmonary disease (COPD) (51 chronic bronchitis and 26 obstructive pulmonary emphysema), and 49 healthy volunteers were enrolled from January 2005 through July 2008. HMGB1 levels were analyzed by Western blot analysis.


RESULTS
The mean value of serum HMGB1 levels in 145 patients with lung cancer was 76.1+/-37.0ng/ml and was significantly higher than those in 77 COPD patients (39.8+/-10.8ng/ml), and 49 healthy control (7.7+/-6.1ng/ml, p<0.0001, respectively); The serum HMGB1 levels were 30.2+/-5.9ng/ml, 60.9+/-22.5ng/ml, 99.0+/-23.1ng/ml and 133.4+/-18.9ng/ml in patients with NSCLC of TNM stage I, II, III, and IV. There were significant differences among four groups (p<0.0001). Moreover, the significant positive correlation between the levels of serum HMGB1 and the size of tumor (r=0.799, p<0.001); The serum HMGB1 levels were 57.2+/-28.8ng/ml in patients with NSCLC before operation, and 26.5+/-14.7ng/ml one month after operation (p<0.0001).


CONCLUSIONS
Our study suggests that HMGB1 may be a useful clinical marker for evaluating the NSCLC progression and is of potential prognostic value.
Shang
Guan-Hong
GH
Department of Respiratory Medicine, Qilu Hospital, School of medicine, Shandong University, Wenhua West Road 107, Jinan 250012, PR China. shangguanhong0516@163.com
Jia
Chong-Qi
CQ
Tian
Hui
H
Xiao
Wei
W
Li
Yu
Y
Wang
Ai-Hua
AH
Dong
Liang
L
Lin
Dian-Jie
DJ
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001991:Bronchitis / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011656:Pulmonary Emphysema / Q000097:blood
D014408:Biomarkers, Tumor; D024243:HMGB1 Protein