title: Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein.
abstract: Malignant myoepithelioma of the breast (MMB) is a rare and often aggressive disease with poor prognosis. Little is known regarding its optimal treatment and progression. We describe the clinical history of a woman following excision of a benign adenomyoepithelioma which recurred years later as a radioresistant malignant myoepithelioma with high levels of ataxia telangiectasia mutated protein and mutant p53 (Cys135Phe). MMB requires close follow-up and aggressive treatment. If adjuvant radiotherapy is adopted to improve local control, minimal postoperative delay and higher doses than for standard post-mastectomy radiation are recommended.
authors.affiliation: Department of Radiation Oncology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of New South Wales, Kogarah, New South Wales, Australia.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Fang
authors.forename: R V
authors.initials: RV
authors.lastname: Tse
authors.forename: V M
authors.initials: VM
authors.lastname: Marjoniemi
authors.forename: S
authors.initials: S
authors.lastname: Kozlov
authors.forename: M F
authors.initials: MF
authors.lastname: Lavin
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: J H
authors.initials: JH
authors.lastname: Kearsley
authors.forename: P H
authors.initials: PH
authors.lastname: Graham
authors.forename: R A
authors.initials: RA
authors.lastname: Clarke
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins; D001943:Breast Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D018797:Cell Cycle Proteins / Q000032:analysis*; D004268:DNA-Binding Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009208:Myoepithelioma / Q000532:radiotherapy*; D017346:Protein Serine-Threonine Kinases / Q000032:analysis*; D017211:Treatment Failure; D025521:Tumor Suppressor Proteins / Q000032:analysis*
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases