Role of specific microRNAs for endothelial function and angiogenesis.
Accumulating evidence indicates that various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells, can be regulated by specific miRNAs in an endothelial-specific manner. As novel molecular targets, miRNAs have a potential value for treatment of angiogenesis-associated diseases such as cancers, inflammation, and vascular diseases. In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis.
Wu
Fusheng
F
Department of Neurosurgery & Physiology, LSU Health Science Center, Shreveport, LA 71130, USA.
Yang
Zeran
Z
Li
Guohong
G
D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000235:genetics; D043244:Ribonuclease III / Q000235:genetics / Q000502:physiology*
D035683:MicroRNAs; D043244:Ribonuclease III