Can modular analysis identify disease-associated candidate genes for therapeutics?
Complex diseases such as allergy change gene expression in several cell types and tissues. Benson and colleagues have now shown, in a paper in BMC Systems Biology, that this complexity can be studied effectively using an integrated experimental and computational modular analysis. Their strategy revealed a core of allergy-associated genes of potential therapeutic value.
Tegnér
Jesper
J
Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, 171 76 Solna, Stockholm, Sweden. jesper.tegner@ki.se
D018926:Anti-Allergic Agents / Q000627:therapeutic use; D001330:Electronic Data Processing; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics* / Q000378:metabolism / Q000628:therapy
D018926:Anti-Allergic Agents