Cytotoxic thiophenes from the root of Echinops grijisii Hance.
A new thiophene, echinothiophenegenol (1), together with seven known thiophenes was isolated from the crude ethanol extract of roots of Echinops grijisii Hance. The structure of 1 was elucidated on the basis of spectroscopic data. Compounds 2 and 5, isolated from the plant for the first time, and compounds 1-7 were tested for their cytotoxicity against two human cancer cell lines, HL60 and K562. The thiophenes showed better activity than the bithiophenes.
Zhang
Peng
P
Institute of Pharmaceutical Informatics, School of Pharmaceutical Sciences, Zhejiang University, Zijingang Campus, No. 388 Yuhangtang Rd., Hangzhou 310058, China.
Liang
Dong
D
Jin
Wenrong
W
Qu
Haibin
H
Cheng
Yiyu
Y
Li
Xian
X
Ma
Zhongjun
Z
D002470:Cell Survival / Q000187:drug effects; D031182:Echinops Plant / Q000737:chemistry*; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D020014:K562 Cells / Q000187:drug effects; D008958:Models, Molecular; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*
D013876:Thiophenes