Synthesis and characterization of new galanthamine derivatives comprising peptide moiety.
New analogues of galanthamine containing peptide fragments either at 6 or 11 position, were synthesized by reaction between galanthamine molecule and dipeptides and tripeptide, derivatives of N-(3,4-dichlorophenyl)-D,L-Ala-OH. The best results according to yields, easily purification of the target products, and simplicity of the scheme realisation was achieved by using of cyanomethyl ester of Boc-Gly-OH as activated compound.
Vezenkov
Lyubomir T
LT
Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 8 Kl. Ohridski blvd., 1756 Sofia, Bulgaria. lvezenkov@yahoo.com
Georgieva
Maria G
MG
Danalev
Dantcho L
DL
Ivanov
Tchavdar B
TB
Ivanova
Galya I
GI
D004151:Dipeptides / Q000138:chemical synthesis; D005702:Galantamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D009842:Oligopeptides / Q000138:chemical synthesis*
D004151:Dipeptides; D009842:Oligopeptides; D005702:Galantamine