Study of efficiency of therapeutic and preventive anaferon (pediatric formulation) in mice with influenza infection.
Therapeutic and preventive treatment of mice intranasally infected with a lethal dose of A/Aichi/2/68 (H3N2) influenza virus with anaferon (pediatric formulation) demonstrated an antiviral effect of the drug (increased percent of survivors and prolonged lifespan).
Shishkina
L N
LN
Vector Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia.
Sergeev
A N
AN
Kabanov
A S
AS
Skarnovich
M O
MO
Evtin
N K
NK
Mazurkova
N A
NA
Sergeev
A A
AA
Belopolskaya
M V
MV
Kheyfets
I A
IA
Dugina
J L
JL
Tarasov
S A
SA
Sergeeva
S A
SA
Epstein
O I
OI
D000281:Administration, Intranasal; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects / Q000472:pathogenicity; D007371:Interferon-gamma / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000276:immunology / Q000401:mortality; D053139:Oseltamivir / Q000627:therapeutic use
D000998:Antiviral Agents; D053139:Oseltamivir; D007371:Interferon-gamma