title: Primary vaginal extraosseous Ewing sarcoma/primitive neuroectodermal tumor with cranial metastasis.
abstract: Extraosseous Ewing sarcoma is now regarded as a member of the Ewing sarcoma/primitive neuroectodermal tumor (PNET) family. It typically involves the soft tissues of the chest wall, pelvis, paravertebral region, abdominal wall, retroperitoneal region and extremities of children, adolescents and young adults, but it seldom occurs in the female genital tract. We report an extremely rare case of retrospective diagnosis of vaginal extraosseous Ewing sarcoma/PNET which metastasized to the right frontoparietal scalp, skull, and dura. Surgical resection, followed by adjuvant radiotherapy and chemotherapy resulted in a favourable clinical outcome. Both the vaginal and head tumors had similar light microscopic features supporting the diagnosis.
authors.affiliation: Division of Neurosurgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C. yip_chiman@yahoo.com
authors.forename: Chi-Man
authors.initials: CM
authors.lastname: Yip
authors.forename: Shu-Shong
authors.initials: SS
authors.lastname: Hsu
authors.forename: Nai-Jen
authors.initials: NJ
authors.lastname: Chang
authors.forename: Jyh-Seng
authors.initials: JS
authors.lastname: Wang
authors.forename: Wei-Chuan
authors.initials: WC
authors.lastname: Liao
authors.forename: Jun-Yih
authors.initials: JY
authors.lastname: Chen
authors.forename: Su-Hao
authors.initials: SH
authors.lastname: Liu
authors.forename: Chih-Hao
authors.initials: CH
authors.lastname: Chen
mesh_terms: D000071443:12E7 Antigen; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001932:Brain Neoplasms / Q000556:secondary*; D015815:Cell Adhesion Molecules / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis / Q000473:pathology*; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000473:pathology*
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules