title: Plectosphaeroic acids A, B, and C, indoleamine 2,3-dioxygenase inhibitors produced in culture by a marine isolate of the fungus Plectosphaerella cucumerina.
abstract: Laboratory cultures of the fungus Plectosphaerella cucumerina obtained from marine sediments collected in Barkley Sound, British Columbia, yielded the novel alkaloids plectosphaeroic acids A (1) to C (3). The alkaloids 1-3 are inhibitors of indoleamine 2,3-dioxygenase (IDO).
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
authors.forename: Gavin
authors.initials: G
authors.lastname: Carr
authors.forename: Wendy
authors.initials: W
authors.lastname: Tay
authors.forename: Helen
authors.initials: H
authors.lastname: Bottriell
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Andersen
authors.forename: A Grant
authors.initials: AG
authors.lastname: Mauk
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D001955:British Columbia; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D020081:Phyllachorales / Q000737:chemistry*
chemical_list: D026121:Indole Alkaloids; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; C542754:plectosphaeroic acid A; C542755:plectosphaeroic acid B; C542756:plectosphaeroic acid C