title: Highly chemoselective Pd-C catalytic hydrodechlorination leading to the highly efficient N-debenzylation of benzylamines.
abstract: In the presence of 1,1,2-trichloroethane, a novel procedure for the Pd-C catalytic N-debenzylation of benzylamines was established. The method proceeded in a synergistic catalytic system and directly gave the products as crystal amine hydrochlorides in practically quantitative yields.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
authors.forename: Chuanjie
authors.initials: C
authors.lastname: Cheng
authors.forename: Jianwei
authors.initials: J
authors.lastname: Sun
authors.forename: Lixin
authors.initials: L
authors.lastname: Xing
authors.forename: Jimin
authors.initials: J
authors.lastname: Xu
authors.forename: Xinyan
authors.initials: X
authors.lastname: Wang
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Hu
mesh_terms: D001596:Benzylamines / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D014240:Trichloroethanes / Q000737:chemistry*
chemical_list: D001596:Benzylamines; D014240:Trichloroethanes; C024567:1,1,2-trichloroethane; D010165:Palladium; D002244:Carbon