Sex-related differences in redistribution of total bilirubin pool after induction and removal of cholestasis in rats.
Experiments on rats revealed sex-related differences in bilirubin concentration in the bile and bile flow rate against the background of obstructive cholestasis. These differences disappeared after gonadectomy. There were no sex-related differences in the rate of bilirubin excretion with the bile after removal of cholestasis, which was attained through different mechanisms in males and females.
Kushnareva
N S
NS
Laboratory of Endocrinology, Biological Faculty, M.V. Lomonosov Moscow State University, Russia. kuwnarevans@pochta.ru
Smirnova
O V
OV
D000818:Animals; D001646:Bile / Q000378:metabolism / Q000502:physiology; D001663:Bilirubin / Q000378:metabolism*; D002779:Cholestasis / Q000503:physiopathology*; D005260:Female; D008297:Male; D051381:Rats; D012737:Sex Factors
D001663:Bilirubin