title: [Serious complications of intraventricular interferon-alpha and ribavirin in the treatment of subacute sclerosing panencephalitis].
abstract: We treated three patients with subacute sclerosing panencephalitis with intraventricular interferon-alpha and oral inosiplex, and followed their clinical courses. One patient was also treated with ribavirin. Results were unsatisfactory; no significant clinical improvement was seen in the patients, and a number of serious complications occurred. Malfunction of the Ommaya reservoir, septic meningitis and chemical encephalopathy were observed in the three patients, respectively. The use of intraventricular interferon-alpha and ribavirin therapy has been increasing despite insufficient evidence of its efficacy. A high risk of serious side effects exists with this therapy. Thus it is important to consider not only the effects but also the side effects and complications as described above. We also propose that a standard protocol for the use of interferon-alpha and ribavirin and the cessation of current therapy is necessary.
authors.affiliation: Department of Child Neurology, National Center Hospital for Neurology and Psychiatry, National Center of Neurology and Psychiatry, Kodaira, Tokyo.
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakagawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nonoda
authors.forename: Asako
authors.initials: A
authors.lastname: Arai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakuma
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Komaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugai
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D017410:Practice Guidelines as Topic; D012254:Ribavirin / Q000008:administration & dosage / Q000009:adverse effects*; D013344:Subacute Sclerosing Panencephalitis / Q000188:drug therapy*
chemical_list: D016898:Interferon-alpha; D012254:Ribavirin