Controlled release study of 5-fluorouracil-loaded chitosan/polyethylene glycol microparticles.
The aim of this research is to reduce the frequency of taking therapeutic drugs. Thus, anti-cancer drug [5-fluorourical (5-FU)] loaded chitosan/polyethylene glycol microparticles were prepared by a phase-inversion technique with tripolyphosphate (TPP) used as a cross-linking agent. The relationships between 5-FU release behavior/encapsulation efficiencies and chitosan concentrations, TPP concentrations, as well as cross-linking time were studied to identify better/superior conditions (3.5 wt% chitosan, 3 wt% TPP, and cross-linking time = 4 h) for preparing 5-FU-loaded microparticles. Furthermore, in order to ascertain the influence of their physical properties on 5-FU release performance, 5-FU-loaded microparticles were evaluated by swelling tests and scanning electron microscopy.
Lin
Chuen-Chang
CC
Department of Chemical & Materials Engineering, National Yunlin University of Science and Technology, Yunlin, Taiwan. linchuen@yuntech.edu.tw
Fu
Chun-Hsien
CH
D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D005472:Fluorouracil / Q000493:pharmacokinetics*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011122:Polyphosphates / Q000737:chemistry; D013678:Technology, Pharmaceutical
D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D011122:Polyphosphates; D011092:Polyethylene Glycols; D048271:Chitosan; C005692:triphosphoric acid; D005472:Fluorouracil