title: Hantaviruses in rodents and humans, Inner Mongolia Autonomous Region, China.
abstract: Surveys were carried out in 2003-2006 to better understand the epidemiology of hantaviruses in the Inner Mongolia Autonomous Region of China (Inner Mongolia). Hemorrhagic fever with renal syndrome (HFRS) was first reported in this region in 1955 and has been an important public health problem here since then. During 1955-2006, 8,309 persons with HFRS were reported in Inner Mongolia (average incidence rate 0.89/100,000), and 261 (3.14%) died. Before the 1990s, all HFRS cases occurred in northeastern Inner Mongolia. Subsequently, HFRS cases were registered in central (1995) and western (1999) Inner Mongolia. In this study, hantaviral antigens were identified in striped field mice (Apodemus agrarius) from northeastern Inner Mongolia and in Norway rats (Rattus norvegicus) from middle and western Inner Mongolia. Phylogenetic analysis of hantaviral genome sequences suggests that HFRS has been caused mainly by Hantaan virus in northeastern Inner Mongolia and by Seoul virus in central and western Inner Mongolia.
authors.affiliation: Chinese Center for Disease Control and Prevention, Changping, Beijing, People's Republic of China. yongzhenzhang@sohu.com
authors.forename: Yong-Zhen
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Feng-Xian
authors.initials: FX
authors.lastname: Zhang
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhao
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Li
authors.forename: Hua-Xin
authors.initials: HX
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Zou
authors.forename: Alexander
authors.initials: A
authors.lastname: Plyusnin
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002681:China / Q000453:epidemiology; D018063:Hantaan virus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D006801:Humans; D015994:Incidence; D008168:Lung / Q000821:virology; D051189:Murinae / Q000821:virology; D010802:Phylogeny; D051381:Rats / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012376:Rodent Diseases / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D029263:Seoul virus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D017422:Sequence Analysis, DNA
chemical_list: D000956:Antigens, Viral