Therapeutic efficacy and hepatotoxicity of a composition of isoniazid and dialdehyde dextran obtained by radiochemical oxidation of dextran.
Tuberculous granulomas were found in all parenchymal organs of mice infected with mycobacteria of BCG vaccine. The number and size of hepatic granulomas decreased, while the count of degenerated and necrobiotic hepatocytes in infected animals increased 3 months after the start of therapy with a composition of isoniazid and dialdehyde dextran. The composition of isoniazid and dialdehyde dextran obtained by radiochemical oxidation of dextran had greater therapeutic efficacy and lower hepatotoxicity.
Shkurupiy
V A
VA
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. sck@soramn.ru
Shklovchik
O V
OV
Troitskii
A V
AV
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use / Q000633:toxicity; D001500:BCG Vaccine / Q000009:adverse effects; D003911:Dextrans / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D054872:Fatty Acid Synthesis Inhibitors / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D006099:Granuloma / Q000188:drug therapy* / Q000382:microbiology; D007538:Isoniazid / Q000627:therapeutic use / Q000633:toxicity; D008099:Liver / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000502:physiology; D010084:Oxidation-Reduction; D011854:Radiochemistry / Q000379:methods*
D000925:Anticoagulants; D001500:BCG Vaccine; D003911:Dextrans; D054872:Fatty Acid Synthesis Inhibitors; C026948:dextran dialdehyde; D007538:Isoniazid