title: Association of parathyroid adenoma and pregnancy with preeclampsia.
abstract: OBJECTIVE
  Case reports have described associations between calcium metabolism disturbances and primary hyperparathyroidism with preeclampsia, suggesting parathyroid involvement in preeclampsia etiology. This study examines whether parathyroid adenoma, the main cause of hyperparathyroidism, diagnosed and treated before pregnancy is associated with preeclampsia.
  
  
  METHODS
  We conducted a register-based study to assess the association between parathyroid adenoma and subsequent preeclampsia.
  
  
  METHODS
  Births among Sweden's general population were studied.
  
  
  METHODS
  The study population included 52 women with a diagnosis of parathyroid adenoma and 519 without, all of whom had a subsequent singleton pregnancy between 1973 and 1997.
  
  
  METHODS
  We performed a conditional logistic regression investigating the association of parathyroid adenoma with subsequent preeclampsia in the first singleton pregnancy with adjustment for potential confounding factors.
  
  
  METHODS
  The main outcome was a diagnosis of preeclampsia that does not include women with prior chronic hypertension. To ensure that treatment of parathyroid adenoma was completed before pregnancy, those with a diagnosis of parathyroid adenoma made less than 2 yr before delivery (and the matched comparison women) were excluded.
  
  
  RESULTS
  Statistically, parathyroid adenoma prior to delivery is significantly (P < 0.001) associated with preeclampsia, producing an adjusted odds ratio of 6.89 (95% confidence interval, 2.30, 20.58).
  
  
  CONCLUSIONS
  A history of parathyroid adenoma should be viewed as a risk for preeclampsia.
authors.affiliation: Department of Surgical Sciences, University Hospital, SE-751 85 Uppsala, Sweden.
authors.forename: Hella
authors.initials: H
authors.lastname: Hultin
authors.forename: Per
authors.initials: P
authors.lastname: Hellman
authors.forename: Ewa
authors.initials: E
authors.lastname: Lundgren
authors.forename: Matts
authors.initials: M
authors.lastname: Olovsson
authors.forename: Anders
authors.initials: A
authors.lastname: Ekbom
authors.forename: Jonas
authors.initials: J
authors.lastname: Rastad
authors.forename: Scott M
authors.initials: SM
authors.lastname: Montgomery
mesh_terms: D000236:Adenoma / Q000150:complications*; D000328:Adult; D005260:Female; D006801:Humans; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000150:complications*; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic
chemical_list: D010281:Parathyroid Hormone