title: [Treatment with venlafaxine extended release for climacteric women with depression or anxiety diagnosis. An open-label study].
abstract: BACKGROUND
  The objective of this observational study was to assess under real clinical practice conditions the effectiveness and safety of venlafaxine extended release in anxiety-depressed and hormone-related symptoms in climacteric women with anxiety or depressive disorders.
  
  
  METHODS
  Observational, prospective, open-label, multicenter, 24-week study, carried out in Spain. A sample of 45 outpatients, adult women between 45 and 55 years of age, diagnosed of depressive disorder, generalized anxiety disorder or social anxiety disorder were analyzed. Venlafaxine extended release was administered for 24 weeks at doses according to the investigator's clinical criteria.
  
  
  RESULTS
  Of the total of 45 patients who were included in the study, 43 (95.6%) completed it. The patients' age range was of 47 to 55 years old, median of 50 and mean of 50.82. The clinical condition evolution was assessed with the evaluation scales scores: Blatt-Kuppermann Menopausal Index, Hamilton Depression Rating Scale, Hamilton Anxiety Scale and Clinical Global Impression. During the 24-week period, a significant decrease in the different scales scores showed a clinical improvement.
  
  
  CONCLUSIONS
  The results achieved show that treatment with venlafaxine extended release significantly improved the clinical condition of climacteric patients with anxiety or depressive disorder. If these results are confirmed with placebo-controlled clinical trials, they will support the utility of Venlafaxine extended release in this kind of patients.
authors.affiliation: Servicio de Psiquatría, Hospital Valle del Nalón Langreo, Asturias. icelso@yahoo.es
authors.forename: C
authors.initials: C
authors.lastname: Iglesias
authors.forename: E
authors.initials: E
authors.lastname: Pato
authors.forename: S
authors.initials: S
authors.lastname: Ocio
authors.forename: J C
authors.initials: JC
authors.lastname: Ortigosa
authors.forename: S
authors.initials: S
authors.lastname: Santamarina
authors.forename: M J
authors.initials: MJ
authors.lastname: Merino
authors.forename: M J
authors.initials: MJ
authors.lastname: Alonso
authors.forename: L
authors.initials: L
authors.lastname: Fernández
authors.forename: J L
authors.initials: JL
authors.lastname: Alonso
authors.forename: L
authors.initials: L
authors.lastname: Rodríguez
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D003511:Cyclohexanols / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D011446:Prospective Studies; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D000069470:Venlafaxine Hydrochloride