Incidence of retinopathy of prematurity in the United States: 1997 through 2005.
OBJECTIVE
To determine the incidence of retinopathy of prematurity (ROP) based on a national database and to identify baseline characteristics, demographic information, comorbidities, and surgical interventions.


METHODS
Retrospective study based on the National Inpatient Sample from 1997 through 2005.


METHODS
The National Inpatient Sample was queried for all newborn infants with and without ROP. Multivariate logistic regression was used to predict risk factors for ROP.


RESULTS
Thirty-four million live births were recorded during the study period. The total ROP incidence was 0.17% overall and 15.58% for premature infants with length of stay of more than 28 days. Our results conclusively demonstrated the importance of low birth weight as a risk for ROP development in infants with length of stay of more than 28 days, as well as association with respiratory conditions, fetal hemorrhage, intraventricular hemorrhage, and blood transfer. An interesting finding was the protective effect conferred by hypoxia, necrotizing enterocolitis, and hemolytic disease of the newborn. Infants with ROP had a higher incidence of undergoing laser photocoagulation therapy, pars plana vitrectomy, and scleral buckle surgery.


CONCLUSIONS
The current study represents a large, retrospective analysis of newborns with ROP. The multivariate analysis emphasizes the role of birth weight in extended-stay infants, as well as respiratory conditions, fetal hemorrhage, intraventricular hemorrhage, and blood transfer.
Lad
Eleonora M
EM
Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94025, USA.
Hernandez-Boussard
Tina
T
Morton
John M
JM
Moshfeghi
Darius M
DM
D001724:Birth Weight; D002543:Cerebral Hemorrhage / Q000453:epidemiology; D015897:Comorbidity; D016208:Databases, Factual; D005260:Female; D005865:Gestational Age; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D012178:Retinopathy of Prematurity / Q000453:epidemiology* / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology