title: Oxidative imbalance in bipolar disorder subtypes: a comparative study.
abstract: OBJECTIVE
  The oxidants are related with the membrane-associated pathologies in the central nervous system and may have an important role in neuropsychiatric disorders. Several studies were performed on the effects of free radicals in bipolar disorder. However, there are no studies investigating the effects of free radicals both in the subtypes of BD (Bipolar disorders I and II) and in antidepressant induced mania (AIM). In this study, we aimed to investigate the status of oxidative metabolism in BD and its subtypes.
  
  
  METHODS
  94 bipolar patients (BD I-II and AIM) diagnosed according to DSM IV and as control group 41 healthy subjects were included to the study. The total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were examined in the properly obtained plasma samples of subjects and healthy controls included in the study.
  
  
  RESULTS
  The patients' TAS, TOS and OSI were significantly higher than the controls. TAS is negatively correlated with the number of previous total episodes in BD I. The BD I group appeared to have higher TOS compared to BD II group.
  
  
  CONCLUSIONS
  Oxidative balance is impaired in bipolar disorder. Antioxidant levels may be increased compensatorily in response to increased oxidant levels. Another important result of our study was that in the comparison of the three disease subtypes BD I group was found to have higher TOS compared to the BD II group. This finding is compatible with the literature on BD I and may be associated with the more severe course of BD I.
authors.affiliation: Psychiatry Department, Gaziantep University, Medical Faculty, Gaziantep, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yumru
authors.forename: Haluk A
authors.initials: HA
authors.lastname: Savas
authors.forename: Aysun
authors.initials: A
authors.lastname: Kalenderoglu
authors.forename: Mahmut
authors.initials: M
authors.lastname: Bulut
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001714:Bipolar Disorder / Q000145:classification* / Q000209:etiology / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008297:Male; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D016877:Oxidants