title: Vitamin C with metabolites reduce oxalate levels compared to ascorbic acid: a preliminary and novel clinical urologic finding.
abstract: The incidence and prevalence of kidney stones are notable and are projected to increase over the next decade. Risk factors for kidney stones abound, but a prominent risk factor is hyperoxaluria, which has numerous etiologies, including vitamin C (ascorbic acid) dietary supplement intake. This randomized, double-blind, crossover study examined the effects of two different vitamin C formulations and found that vitamin C with metabolites (Ester-C) significantly reduced urine oxalate levels compared to ascorbic acid. This is a potential novel finding that requires further clinical evaluation.
authors.affiliation: University of Michigan Medical Center, Department of Urology, Ann Arbor, MI, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Moyad
authors.forename: Maile A
authors.initials: MA
authors.lastname: Combs
authors.forename: David C
authors.initials: DC
authors.lastname: Crowley
authors.forename: Joshua E
authors.initials: JE
authors.lastname: Baisley
authors.forename: Prachi
authors.initials: P
authors.lastname: Sharma
authors.forename: Angelica S
authors.initials: AS
authors.lastname: Vrablic
authors.forename: Malkanthi
authors.initials: M
authors.lastname: Evans
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000494:pharmacology*; D018592:Cross-Over Studies; D003683:Dehydroascorbic Acid / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006959:Hyperoxaluria / Q000517:prevention & control*; D007669:Kidney Calculi / Q000517:prevention & control*; D008297:Male; D010070:Oxalates / Q000652:urine; D013912:Threonine / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D010070:Oxalates; C069207:calcium ascorbate; D013912:Threonine; D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid