title: Manipulation of Sod1 expression ubiquitously, but not in the nervous system or muscle, impacts age-related parameters in Drosophila.
abstract: Superoxide dismutase 1 (SOD1) is an important antioxidant previously shown to impact life span in Drosophila. We examined the consequences of manipulating Sod1 expression throughout the body or in the nervous system or musculature on life span and age-related locomotor impairment (ARLI) in Drosophila. Ubiquitous overexpression of SOD1 extended life span but did not substantially forestall ARLI, whereas ubiquitous knock-down of Sod1 shortened life span and accelerated ARLI. Interestingly, neither overexpression of Sod1 nor expression of Sod1 RNAi in the nervous system or muscle altered life span or ARLI. Our studies suggest that the control of reactive oxygen species by SOD1 in tissues other than the nervous system and musculature support life span and ARLI in Drosophila.
authors.affiliation: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors.forename: Ian
authors.initials: I
authors.lastname: Martin
authors.forename: Melanie A
authors.initials: MA
authors.lastname: Jones
authors.forename: Mike
authors.initials: M
authors.lastname: Grotewiel
mesh_terms: D000818:Animals; D016922:Cellular Senescence; D004330:Drosophila / Q000201:enzymology* / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008136:Longevity; D008297:Male; D009132:Muscles / Q000201:enzymology; D009420:Nervous System / Q000201:enzymology; D034622:RNA Interference; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D000072105:Superoxide Dismutase-1
chemical_list: C000606290:SOD1 protein, human; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1