Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm.
OBJECTIVE
To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA).


METHODS
Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (-1360C>T, and +649C>T) in men with AAA (n=678) and in controls (n=659) was examined using multivariate analyses. The association with AAA expansion (n=638) was also assessed.


RESULTS
In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected.


CONCLUSIONS
MMP2 -1360C>T and +649C>T variants are not risk factors for AAA.
Smallwood
L
L
School of Surgery, University of Western Australia, Fremantle Hospital, Fremantle, WA 6959, Australia.
Warrington
N
N
Allcock
R
R
van Bockxmeer
F
F
Palmer
L J
LJ
Iacopetta
B
B
Golledge
J
J
Norman
P E
PE
D017544:Aortic Aneurysm, Abdominal / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008403:Mass Screening; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D014904:Western Australia / Q000453:epidemiology
C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2