title: How to Grb2 a Gab.
abstract: In this issue of Structure, Harkiolaki et al. use crystallography, peptide arrays and isothermal calorimetry to provide a detailed insight into the interaction between the C-terminal SH3 domain of adaptor protein Grb2 bound to the docking protein Gab2.
authors.affiliation: Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-University, 79104 Freiburg, Germany.
authors.forename: Franziska U
authors.initials: FU
authors.lastname: Wöhrle
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Daly
authors.forename: Tilman
authors.initials: T
authors.lastname: Brummer
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D020816:Amino Acid Motifs / Q000235:genetics; D001665:Binding Sites / Q000235:genetics; D051380:GRB2 Adaptor Protein / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D017434:Protein Structure, Tertiary / Q000235:genetics; D018909:src Homology Domains / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C490895:GAB2 protein, human; D051380:GRB2 Adaptor Protein