title: Identification of a novel HLA-DRB1*12 allele, DRB1*1218, in Chinese population.
abstract: Here, we report the identification of a novel human leukocyte antigen-DRB1*12 variant, DRB1*1218 allele, in a Chinese Han individual. The novel DRB1*12 variant allele differed from the closest allele DRB1*120201 by nucleotide 262 G>C (codon 59 GAG>CAG) missense mutation in exon 2, which resulted in an amino acid substitution of Glu>Gln.
authors.affiliation: Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, China.
authors.forename: S-Q
authors.initials: SQ
authors.lastname: Gao
authors.forename: Z-H
authors.initials: ZH
authors.lastname: Deng
authors.forename: Y-P
authors.initials: YP
authors.lastname: Xu
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D017931:DNA Primers / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005091:Exons; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D005998:Glycine / Q000378:metabolism; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007438:Introns; D008863:Microspheres; D008969:Molecular Sequence Data; D044382:Population Groups / Q000235:genetics*; D011933:Reagent Kits, Diagnostic; D017422:Sequence Analysis, DNA / Q000379:methods; D012689:Sequence Homology, Nucleic Acid; D009626:Terminology as Topic
chemical_list: D017931:DNA Primers; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D011933:Reagent Kits, Diagnostic; D005998:Glycine