title: Cognitive deterioration after venlafaxine overdose.
abstract: BACKGROUND
  Venlafaxine is an antidepressant whose adverse event profile is similar to that of the SSRIs (selective serotonin reuptake inhibitors). Serious complications due to venlafaxine overdose have been described. These generally have been resolved with supportive measures alone. However, although patients usually recover even after massive intake of the drug, death may occur in rare cases.
  
  
  OBJECTIVE
  This article reports a case of dementia after an overdose of venlafaxine.
  
  
  METHODS
  We present a case of severe cognitive deterioration in a 48-year-old woman after venlafaxine overdose in a suicide attempt. She became comatose after the overdose. On recovery from the coma, she suffered irreversible motor and cognitive alterations and seizures. Several factors could justify the possible association of these side effects with venlafaxine overdose: time relationship, severe focal deficit and other neurological signs, symptomatic fluctuation, relationship of serotonin networks with the cognitive functions and deficits related to the network damage, and the potential capacity of venlafaxine to damage the central nervous system. However, other alternatives, especially factors that could implicate a hypoxic encephalopathy as the origin of the dementia, cannot be entirely ruled out.
  
  
  CONCLUSIONS
  Venlafaxine seems to have special toxicity vis-à-vis the SSRIs, and this case adds to the literature supporting this. Cognitive function should be monitored after an overdose with venlafaxine.
authors.affiliation: Department of Psychiatry, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: García-Cabeza
authors.forename: Maria Martín Martín
authors.initials: MM
authors.lastname: de Blas
authors.forename: María Mar
authors.initials: MM
authors.lastname: Epifanio
authors.forename: Manuel González
authors.initials: MG
authors.lastname: de Chávez
mesh_terms: D003072:Cognition Disorders / Q000139:chemically induced*; D003511:Cyclohexanols / Q000506:poisoning*; D062787:Drug Overdose / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D017367:Selective Serotonin Reuptake Inhibitors / Q000506:poisoning*; D013406:Suicide, Attempted; D000069470:Venlafaxine Hydrochloride
chemical_list: D003511:Cyclohexanols; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride