Data assimilation for heterogeneous networks: the consensus set.
Data assimilation in dynamical networks is intrinsically challenging. A method is introduced for the tracking of heterogeneous networks of oscillators or excitable cells in a nonstationary environment, using a homogeneous model network to expedite the accurate reconstruction of parameters and unobserved variables. An implementation using ensemble Kalman filtering to track the states of the heterogeneous network is demonstrated on simulated data and applied to a mammalian brain network experiment. The approach has broad applicability for the prediction and control of biological and physical networks.
Sauer
Timothy D
TD
Department of Mathematical Sciences, George Mason University, Fairfax, Virginia 22030, USA. tsauer@gmu.edu
Schiff
Steven J
SJ
D003198:Computer Simulation; D030562:Databases, Protein; D020869:Gene Expression Profiling / Q000379:methods*; D008954:Models, Biological; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D020543:Proteome