title: Effects of acupuncture on expressions of the transcription factors NF-E2, YB-1, LRG47 in the SAMP10 mice.
abstract: OBJECTIVE
  To explore the mechanism of acupuncture for delaying aging.
  
  
  METHODS
  Using the senescence accelerated mouse pattern SAMP10 and the normal aging mice SAMR1 as models and applying RT-PCR and digoxin (DIG)-labeled Northern blot technique to observe expressions of NF-E2, YB-1, LRG47 genes in the forebrain, cortex and hippocampus in a 8-month old SAMR1 control group, a 8-month old SAMP10 control group, a 8-month old SAMP10 acupuncture group and a 8-month old SAMP10 non-point stimulation group.
  
  
  RESULTS
  In the SAMP10 control group, the expressions of NF-E2, YB-1 and LRG47 were down-regulated in the forebrain, cortex and hippocampus, and after acupuncture they were up-regulated and tended to normal.
  
  
  CONCLUSIONS
  The brain aging of the SAMP10 mice is related with abnormal expressions of NF-E2, YB-1 and LRG47 genes; and acupuncture can regulate the expressions of NF-E2, YB-1 and LRG47 genes, strengthening the functions of erythrocyte series, increasing the proliferation of cells and enhancing the cellular immune function in anti-bacteria, hence delaying aging.
authors.affiliation: The First Hospital Affiliated to Tianjin College of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
authors.forename: Jian-chun
authors.initials: JC
authors.lastname: Yu
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Ding
authors.forename: Jingoxian
authors.initials: J
authors.lastname: Han
mesh_terms: D015670:Acupuncture Therapy; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D050984:NF-E2 Transcription Factor, p45 Subunit / Q000235:genetics* / Q000378:metabolism; D011897:Random Allocation; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D019204:GTP-Binding Proteins; D050984:NF-E2 Transcription Factor, p45 Subunit; D014157:Transcription Factors; C096000:Ifi1 protein, mouse; C494693:Nfe2 protein, mouse; C541744:Ybx1 protein, mouse