Differential regulation of gene expression and release of FSH and prolactin by long day and sulfamethazine in chicks.
In several avian species long day exposure results in plasma elevation of gonadotropins and prolactin (PRL). We examined the early (12-72h) effects of photostimulation on mRNA transcripts and plasma levels of follicle stimulating hormone (FSH) and PRL in three-week old cockerels. In addition, the neuroendocrine influence of the compound, sulfamethazine (SMZ), known to enhance light-induced gonadal development in chicks, was studied when applied with or without long-day photostimulation. Both long day exposure and SMZ intake caused a rapid increase in FSHbeta mRNA transcripts at Zeitgeber time 48 (ZT48), while only SMZ stimulated secretion of the hormone into plasma during the course of the study. In contrast to SMZ treatment, photostimulation was more effective at stimulating PRL mRNA transcripts and secretion of PRL. Results demonstrate a differential role of long day exposure and SMZ intake on the regulation of FSH and PRL synthesis and secretion and suggest that some effects of SMZ on gonadal development may be mediated by the pituitary.
Li
Hongyan
H
Poultry Science Center, University of Arkansas, Fayetteville, AR 72701, USA. Hongyan.Li@uth.tmc.edu
Proudman
John
J
Kuenzel
Wayne J
WJ
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D002645:Chickens; D005640:Follicle Stimulating Hormone / Q000097:blood*; D015870:Gene Expression / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D017440:Photoperiod; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D011388:Prolactin / Q000097:blood*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013418:Sulfamethazine / Q000494:pharmacology*
D000890:Anti-Infective Agents; D013418:Sulfamethazine; D011388:Prolactin; D005640:Follicle Stimulating Hormone