title: Chronic immobilization stress induces anxiety- and depression-like behaviors and decreases transthyretin in the mouse cortex.
abstract: In this study, we examined the changes in gene expression in the mouse cortex following chronic stress and behavioral tests. Mice were subjected to immobilization stress for 2h per day for 15 consecutive days and the behavior of the mice was examined. The mice in the experimental group were more anxious and depressive than the control mice. The expression of mRNA in the cortex was analyzed by microarray analysis and 63 genes were found to show a greater than twofold change in expression between the control and experimental groups. Transthyretin was further investigated because its expression showed the greatest fold change. Transthyretin mRNA expression decreased in a chronic stress-specific manner, and protein levels were reduced in the cortex but not in the choroid plexus.
authors.affiliation: Department of Anatomy and Neurobiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, 92 Chilam-dong, Jinju 660-751, Republic of Korea.
authors.forename: Yeon
authors.initials: Y
authors.lastname: Joo
authors.forename: Kyung Mi
authors.initials: KM
authors.lastname: Choi
authors.forename: Young Hyurk
authors.initials: YH
authors.lastname: Lee
authors.forename: Gyeongwha
authors.initials: G
authors.lastname: Kim
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Lee
authors.forename: Gu Seob
authors.initials: GS
authors.lastname: Roh
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Gyeong Jae
authors.initials: GJ
authors.lastname: Cho
authors.forename: Wan Sung
authors.initials: WS
authors.lastname: Choi
authors.forename: Hyun Joon
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D001007:Anxiety / Q000209:etiology* / Q000378:metabolism / Q000523:psychology; D001522:Behavior, Animal; D002540:Cerebral Cortex / Q000378:metabolism*; D002908:Chronic Disease; D003863:Depression / Q000209:etiology* / Q000378:metabolism / Q000523:psychology; D055106:Genome-Wide Association Study; D007103:Immobilization; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011228:Prealbumin / Q000378:metabolism*; D013315:Stress, Psychological / Q000150:complications*
chemical_list: D011228:Prealbumin