title: Impulse flow in sympathetic efferents of the abdominal aortic nerve after intrathecal administration of the substrate and inhibitor of nitric oxide synthase.
abstract: Experiments were performed on rats anesthetized with urethane and nembutal. Intrathecal administration of a nitric oxide inhibitor L-NAME (60 mg) into the cerebrospinal fluid of the thoracic spinal cord was followed by a 40-45% decrease in tonic activity of efferent fibers of the abdominal aortic nerves. L-NAME reduced a reflex increase in the rate of efferent impulses, which was induced by tetanic stimulation of afferent C-fibers in the mesenteric nerve. Administration of L-arginine into the cerebrospinal fluid of the spinal cord (80 mg/20 ml) was accompanied a long-term increase in tonic activity of efferent fibers of the abdominal aortic nerves (by 15-20%). These changes reflect a prolonged activating effect of L-arginine on sympathetic structures.
authors.affiliation: Department of Human and Animal Physiology, Belarussian State University, Minsk, Belarus. rutkevitch@inbox.ru
authors.forename: S A
authors.initials: SA
authors.lastname: Rutkevich
authors.forename: S A
authors.initials: SA
authors.lastname: Polenov
authors.forename: A G
authors.initials: AG
authors.lastname: Chumak
authors.forename: V A
authors.initials: VA
authors.lastname: Kulchitsky
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D007278:Injections, Spinal; D019331:NG-Nitroarginine Methyl Ester / Q000008:administration & dosage / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology*
chemical_list: D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester