title: Severe hyponatremia due to inappropriate secretion of antidiuretic hormone following pleurodesis.
abstract: A 69-year-old man was diagnosed as having syndrome of inappropriate secretion of antidiuretic hormone (SIADH) (serum sodium: 113 mEq/L) 13 days after a right upper lobectomy due to squamous cell carcinoma of the lung (pT1N0M0, stage IA) whereas the preoperative serum sodium level was nearly normal. He had undergone pleurodesis by instillation of OK432 at 2 and 5 days after surgery for prolonged air leakage. Since other possible causes of SIADH, such as residue of lung cancer, pulmonary infections, brain disorders, or known causative drugs were ruled out, the SIADH in this patient was likely associated with pleurodesis by the use of OK-432. A review of similar cases reported suggests that it is important to be aware of the possibility of severe hyponatremia due to SIADH after chemical pleurodesis.
authors.affiliation: Division of Respiratory Medicine, the Tokyo Metropolitan Geriatric Hospital.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Higashihara
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kimbara
authors.forename: Yohei
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Eriko
authors.initials: E
authors.lastname: Kawate
authors.forename: Hideki
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000150:complications*; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D010844:Picibanil / Q000008:administration & dosage / Q000009:adverse effects; D018700:Pleurodesis / Q000009:adverse effects* / Q000379:methods; D012964:Sodium / Q000097:blood
chemical_list: D000970:Antineoplastic Agents; D010844:Picibanil; D012964:Sodium