title: [Pharmacological hypertension therapy].
abstract: Drug therapy in uncomplicated hypertension can be initiated with either ACE-inhibitors, angiotensin II receptor antagonists, calcium channel blockers or thiazides. In younger patients, the first three classes are preferable. Beta-blockers are first-line drugs for hypertension in patients with cardiac comorbidity. Initial combination therapy is indicated in high-risk patients where blood pressure reduction of > 20/10 mmHg is desired. Resistant hypertension generally calls for an increment in diuretic dosage and/or addition of a potassium-sparing diuretic.
authors.affiliation: Medicinsk Afdeling, Regionshospitalet Viborg, DK-8800 Viborg. lederballe@dadlnet.dk
authors.forename: Ole Lederballe
authors.initials: OL
authors.lastname: Pedersen
authors.forename: Kent Lodberg
authors.initials: KL
authors.lastname: Christensen
authors.forename: Lia E
authors.initials: LE
authors.lastname: Bang
authors.forename: Hans
authors.initials: H
authors.lastname: Ibsen
authors.forename: Peter
authors.initials: P
authors.lastname: Schultz-Larsen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D049971:Thiazides / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004232:Diuretics; D049971:Thiazides