The associations among eNOS G894T gene polymorphism, erectile dysfunction, and benign prostate hyperplasia-related lower urinary tract symptoms.
BACKGROUND
A number of literature has now identified the role of impaired nitric oxide synthase/nitric oxide pathway in the endothelium as the central to the development of erectile dysfunction (ED) and benign prostate hyperplasia-related lower urinary tract symptoms (BPH/LUTS). Recently a few studies have reported the associations between endothelial nitric oxide synthase (eNOS) G894T gene polymorphisms and ED. However, there has been no report investigating the eNOS G894T genetic susceptibility factor for both ED and BPH/LUTS.


OBJECTIVE
To investigate the possible associations among eNOS G894T polymorphism, ED, and BPH/LUTS in a Taiwanese population.


METHODS
Patients with ED were defined as those having a 5-item International Index of Erectile Function-5 <21.


METHODS
In all, 372 Taiwanese men underwent a free health screening were enrolled. All the men had complete clinical data and questionnaires taken. The eNOS G894T polymorphisms were determined using the polymerase chain reaction-restriction fragment length polymorphism method.


RESULTS
Three hundred seventy-two men had a mean (standard deviation) age of 60.2 (8.8) years. With multivariate analysis, our data identified that aging, diabetes mellitus (DM), and eNOS G894T gene polymorphism were three independent common risk factors for both ED and BPH/LUTS (P < 0.001, P = 0.036, and P = 0.039 for ED; P = 0.034, P = 0.004, and P = 0.016 for BPH/LUTS, respectively). The eNOS 894T allele carriers had significantly higher prevalence of ED (77.9% vs. 60.4%, P = 0.012) and higher International Prostate Symptom score (IPSS) (13.3 +/- 10.7 vs. 9.3 +/- 7.8, P = 0.001) than G allele carriers.


CONCLUSIONS
Our results showed that aging, DM, and eNOS 894T allele carrier gene polymorphism were the three independently common risk factors for both ED and BPH/LUTS in the Taiwanese population. The eNOS 894T allele carriers had significantly higher frequencies of ED and higher IPSS, suggesting that eNOS G894T gene polymorphisms may play an implication as a genetic susceptibility factor for both ED and BPH/LUTS.
Lee
Yung-Chin
YC
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Wu
Wen-Jeng
WJ
Liu
Chia-Chu
CC
Wang
Chii-Jye
CJ
Li
Wei-Ming
WM
Huang
Chun-Hsiung
CH
Yeh
Hsin-Chih
HC
Ke
Hung-Lung
HL
Huang
Shu-Pin
SP
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D048909:Diabetes Complications / Q000150:complications; D007172:Erectile Dysfunction / Q000150:complications / Q000235:genetics*; D005838:Genotype; D006801:Humans; D018783:Impotence, Vasculogenic / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D013624:Taiwan; D014570:Urologic Diseases / Q000235:genetics
D019001:Nitric Oxide Synthase