Case report: malignant teratoma of the uterine corpus.
BACKGROUND
Teratomas are the commonest germ cell tumours and are most frequently found in the testes and ovary. Extragonadal teratomas are rare and mainly occur in midline structures. Uterine teratomas are extremely rare with only a few previous case reports, usually involving mature teratomas of the uterine cervix.


METHODS
We report an 82-year-old lady presenting with post-menopausal bleeding. Initial investigations revealed a benign teratoma of the uterus which was removed. Her symptoms persisted and a recurrent, now malignant, teratoma of the uterine corpus was resected at hysterectomy. Six months after surgery she relapsed with para-aortic lymphadenopathy and was treated with a taxane, etoposide and cisplatin-containing chemotherapy regimen followed by retroperitoneal lymph node dissection.


CONCLUSIONS
In this report we discuss the aetiology, diagnosis and management of uterine teratomas, and review previous case studies.
Newsom-Davis
Thomas
T
Department of Medical Oncology, Imperial College School of Medicine, Charing Cross Hospital, London, UK. t.ndavis04@imperial.ac.uk
Poulter
Daniel
D
Gray
Rebecca
R
Ameen
Mohammed
M
Lindsay
Iain
I
Papanikolaou
Kyriakos
K
Butler-Manuel
Simon
S
Christmas
Timothy
T
Townsend
Peter
P
Seckl
Michael
M
D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008206:Lymphatic Diseases / Q000209:etiology; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D013724:Teratoma / Q000175:diagnosis*; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000175:diagnosis*
D005047:Etoposide; D002945:Cisplatin