title: Neuropsychological correlates of eye movement abnormalities in schizophrenic patients and their unaffected relatives.
abstract: Impairments on neuropsychological and eye movement tasks have been demonstrated in schizophrenic patients and also reported in their unaffected relatives. However, it is not clear to what extent these phenotypes overlap. This study examined the relationship between specific eye movement and neuropsychological measures. The relationship between performance on eye movement and neuropsychological tasks was measured in 79 schizophrenic patients (63% from multiply affected families), 129 of their healthy first-degree relatives, and 72 normal controls. Antisaccade scores were correlated with most measures of neurocognitive functioning, and this correlation was strongest in schizophrenic patients in all cases. In the schizophrenic patients, but not their relatives or controls, the antisaccade distractibility error (ADE) score correlated significantly with current intelligence, verbal memory (immediate and delayed recall), and associative learning. In the case of crystallised IQ and delayed verbal memory, smaller correlations were present in unaffected relatives, although neither survived Bonferroni correction. Smooth pursuit performance was unrelated to any neuropsychological measure. Our study suggests that antisaccade errors are likely to represent part of a generalized neuropsychological deficit in schizophrenia.
authors.affiliation: Institute of Psychiatry, Psychological Medicine & Psychiatry, Denmark Hill, DeCrespigny Park, London SE5 8AF, United Kingdom. j.zanelli@iop.kcl.ac.uk
authors.forename: Jolanta
authors.initials: J
authors.lastname: Zanelli
authors.forename: James
authors.initials: J
authors.lastname: MacCabe
authors.forename: Timothea
authors.initials: T
authors.lastname: Toulopoulou
authors.forename: Muriel
authors.initials: M
authors.lastname: Walshe
authors.forename: Colm
authors.initials: C
authors.lastname: McDonald
authors.forename: Robin
authors.initials: R
authors.lastname: Murray
mesh_terms: D000328:Adult; D004185:Disability Evaluation; D005190:Family / Q000523:psychology*; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D007858:Learning / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015835:Ocular Motility Disorders / Q000209:etiology* / Q000523:psychology*; D011340:Problem Solving / Q000502:physiology; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D055815:Young Adult