title: [Alzheimer's disease and methylenetetrahydrofolate reductase gene polymorphisms: a potential nutrigenomic approach for Mexico].
abstract: The establishment of medical genomics in Mexico offers the possibility to study in a more comprehensive manner the etiological factors of different diseases, providing a global view of the interaction between the genome and the environment. Nutrition is recognized as a significant determinant in several diseases, yet its interaction with polymorphisms, and in general with the genome, has not been properly addressed Mexico has a high prevalence of polymorphisms of the methylenetetrahydrofolate reductase gene, and in both clinical and basic studies this has been associated with an increased susceptibility of developing Alzheimer's disease. We propose a potential nutrigenomic approach for the study of Alzheimer disease in Mexico.
authors.affiliation: Grupo de Estudio de Neuropsicoendocrinología del Síndrome Metabólico, Facultad de Medicina, Universidad Autónoma de Yucatán, Mérida, Yuc., México. ji.castillo.quan@gmail.com
authors.forename: Jorge I
authors.initials: JI
authors.lastname: Castillo-Quan
authors.forename: Julia M
authors.initials: JM
authors.lastname: Pérez-Osorio
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics*; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008800:Mexico; D054647:Nutrigenomics; D011110:Polymorphism, Genetic
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)