[Prognostic role of apoptosis-related gene Fas-1377 and -670 polymorphisms in breast cancer].
OBJECTIVE
To investigate the correlations between Fas-1377 and -670 polymorphisms and survival in Chinese women with breast cancer.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP) was used to detect the polymorphism of Fas gene in 310 breast cancer patients with a long-term follow-up (median 10.5 years, range 0.2 - 16.1 years). Survival curves were analyzed by Kaplan-Meier method.


RESULTS
The polymorphism of neither Fas-1377 nor Fas-670 was significantly correlated with the overall survival in this series of 310 cases (P > 0.05). However, among 146 patients without lymph node metastasis, the 5-year overall survival (OS) rate was significantly lower in the patients with Fas-1377 AA genotype than that in the patients with Fas-1377 GA or GG genotype (OS: 66.7% vs. 95.4%, P = 0.03). Among 117 patients with lymph node metastasis, both the Fas-1377 and Fas-670 polymorphisms were not significantly correlated with OS (P = 0.42).


CONCLUSIONS
Among breast cancer patients without lymph node metastasis, patients with Fas-1377 AA genotype may have a worse survival, while patients with Fas-1377 GA or GG genotype may not be so.
Hu
Ying
Y
Breast Cancer Center, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100036, China.
Xu
Ye
Y
Wang
Yan
Y
Ouyang
Tao
T
Li
Jin-feng
JF
Wang
Tian-feng
TF
Fan
Zhao-qing
ZQ
Fan
Tie
T
Lin
Ben-yao
BY
Geng
Pai-li
PL
Xie
Yun-tao
YT
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult; D019014:fas Receptor / Q000235:genetics* / Q000378:metabolism
C491901:FAS protein, human; D019014:fas Receptor