Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
Silver nanoparticles, as well as antimicrobial peptides (AMPs), can be used to fight infectious diseases. Since AMPs are known to permeabilize bacterial membranes and might therefore help silver nanoparticles to access internal target sites, we investigated their combined activities and showed synergistic effects between polymyxin B and silver nanoparticles for gram-negative bacteria.
Ruden
Serge
S
KIT, IOC, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
Hilpert
Kai
K
Berditsch
Marina
M
Wadhwani
Parvesh
P
Ulrich
Anne S
AS
D016954:Acinetobacter calcoaceticus / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D004357:Drug Synergism; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D053768:Metal Nanoparticles; D008826:Microbial Sensitivity Tests; D011511:Proteus / Q000187:drug effects; D011551:Pseudomonas fluorescens / Q000187:drug effects; D018030:Silver Compounds / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D018030:Silver Compounds