Identification of candidate genes for susceptibility to reactive arthritis.
This study was undertaken to evaluate the gene expression profile in monocytes from three patients with reactive arthritis (ReA) in remission in order to identify candidate genes accounting for a potential susceptibility to ReA. Gene expression analyses revealed eight differentially expressed mRNA transcripts in monocytes of ReA patients. The major part of genes encoded cytokines, growth factors and chemokines. There was a remarkably high proportion of proangiogenic factors, in particular IP10, ENA-78, and IL-8 accounting for a genetically determined susceptibility to ReA at the host cell level.
Rihl
Markus
M
Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany. rihl.markus@mh-hannover.de
Barthel
Christian
C
Klos
Andreas
A
Schmidt
Reinhold E
RE
Tak
Paul P
PP
Zeidler
Henning
H
Kuipers
Jens G
JG
D016918:Arthritis, Reactive / Q000235:genetics* / Q000382:microbiology*; D016022:Case-Control Studies; D054365:Chemokine CXCL5 / Q000235:genetics*; D002690:Chlamydia Infections; D002692:Chlamydia trachomatis; D016360:Clostridioides difficile; D004761:Enterocolitis, Pseudomembranous; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D000091402:Prohibitins; D012333:RNA, Messenger / Q000097:blood / Q000235:genetics; D018121:Receptors, Cytokine / Q000235:genetics*; D015009:Yersinia Infections; D015008:Yersinia enterocolitica
C486263:CXCL5 protein, human; D054365:Chemokine CXCL5; C104577:IP10-Mig receptor; D016209:Interleukin-8; C000717331:PHB2 protein, human; D000091402:Prohibitins; D012333:RNA, Messenger; D018121:Receptors, Cytokine