title: Role of specific microRNAs for endothelial function and angiogenesis.
abstract: Accumulating evidence indicates that various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells, can be regulated by specific miRNAs in an endothelial-specific manner. As novel molecular targets, miRNAs have a potential value for treatment of angiogenesis-associated diseases such as cancers, inflammation, and vascular diseases. In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis.
authors.affiliation: Department of Neurosurgery & Physiology, LSU Health Science Center, Shreveport, LA 71130, USA.
authors.forename: Fusheng
authors.initials: F
authors.lastname: Wu
authors.forename: Zeran
authors.initials: Z
authors.lastname: Yang
authors.forename: Guohong
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000235:genetics; D043244:Ribonuclease III / Q000235:genetics / Q000502:physiology*
chemical_list: D035683:MicroRNAs; D043244:Ribonuclease III