Leprosy reaction as a manifestation of immune reconstitution inflammatory syndrome: a case series of a Brazilian cohort.
Several case reports have demonstrated that the immune reconstitution inflammatory syndrome induces reversal reaction in HIV and leprosy-coinfected patients. The present study describes 10 cases of immune reconstitution inflammatory-associated reversal reaction. The patients evolved satisfactorily despite presenting a more severe form of the disease and the fact that three required an additional use of corticoids. The present study, the largest case series published to date, demonstrates that leprosy reaction is a manifestation of immune reconstitution.
Menezes
Vinicius Martins
VM
Sales
Anna Maria
AM
Illarramendi
Ximena
X
Miranda
Alice
A
Gonçalves Morgado
Mariza
M
Gutierrez-Galhardo
Maria Clara
MC
Nunes Sarno
Euzenir
E
da Costa Nery
José Augusto
JA
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications* / Q000276:immunology; D007918:Leprosy / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D055815:Young Adult