title: [Characteristics of autoimmune reactions in chronic cardiac failure of different etiology].
abstract: OBJECTIVE
  To characterize autoimmune reactions in patients with chronic cardiac failure (CCF) of different etiology.
  
  
  METHODS
  Basic markers of immune activation were measured in 43 patients with coronary heart disease stage I-IIB (NYHA FC I-IV) and 44 patients with dilated cardiomyopathy (DCMP) stage I-IIB (NYHA FC I-IV). Antibodies to myocardial tissue were studied with indirect immunofluorescence. Echocardiography was made by standard recommendations with evaluation of systolic and diastolic left ventricular function. Concentrations of C-reactive protein, IgG, IgA, IgM were estimated nephelometrically. Enzyme immunoassay studied serum levels of IL-8, IL-2R, IL-6, IL-18, IL-10, IFN-gamma, endothelin.
  
  
  RESULTS
  Patients with DCMP had higher titers of antimyocardial autoantibodies than in coronary heart disease (CHD) reflecting more severe autoimmune inflammation. In CHD endothelial, systolic and diastolic dysfunctions severity correlated with severity of inflammation.
  
  
  CONCLUSIONS
  Some characteristics of autoimmune reactions in CCF determine severity of the disease course.
authors.forename: K A
authors.initials: KA
authors.lastname: Zykov
authors.forename: S N
authors.initials: SN
authors.lastname: Tatenkulova
authors.forename: V P
authors.initials: VP
authors.lastname: Masenko
authors.forename: T V
authors.initials: TV
authors.lastname: Kuznetsova
authors.forename: A V
authors.initials: AV
authors.lastname: Rvacheva
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Belenkov
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D015551:Autoimmunity; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D002908:Chronic Disease; D004452:Echocardiography; D016232:Endothelins / Q000097:blood; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006333:Heart Failure / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D007378:Interleukins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000276:immunology*; D012720:Severity of Illness Index; D016277:Ventricular Function, Left / Q000502:physiology; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D016232:Endothelins; D007378:Interleukins; D007371:Interferon-gamma