A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing.
This study describes a novel gel based vehicle for the delivery of acetylcholine (ACh) during quantitative sudomotor axon reflex testing (QSART). A dose and current response study were undertaken on 20 healthy control participants to characterize the efficiency of a gel based vehicle for the delivery of ACh. Values obtained for total sweat volume and latency to sweat onset with gel iontophoresis of ACh during QSART were comparable to previously published normative data using solution based vehicles. Patient discomfort, utilizing the gel based vehicle during the QSART procedure, was minimal. Improvement in iontophoresis using the gel formulation as a vehicle for ACh delivery has the potential to lower the voltage required to overcome skin resistance during QSART and may result in improved patient comfort during the procedure.
Sletten
David M
DM
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Kimpinski
Kurt
K
Weigand
Stephen D
SD
Low
Phillip A
PA
D000109:Acetylcholine / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001338:Autonomic Fibers, Postganglionic / Q000187:drug effects* / Q000502:physiology*; D001703:Biophysics; D018678:Cholinergic Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011930:Reaction Time / Q000187:drug effects; D012018:Reflex / Q000187:drug effects*; D013546:Sweating / Q000187:drug effects; D055815:Young Adult
D018678:Cholinergic Agents; D005782:Gels; D000109:Acetylcholine