title: Trisulfonated porphyrazines: new photosensitizers for the treatment of retinal and subretinal edema.
abstract: A new series of water-soluble, mononaphthotrisulfobenzoporphyrazines, bearing an alkynyl side chain of varying lengths on the naphtho ring, were prepared and tested for their efficacy to inhibit plasma extravasation when used as photosensitizers during photodynamic therapy (PDT) of the retina in the rat. The hexynyl substituted photosensitizer was the most potent, and was able to produce complete inhibition, at low doses of photosensitizer and light.
authors.affiliation: Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada. johan.e.vanlier@usherbrooke.ca
authors.forename: Johan E
authors.initials: JE
authors.lastname: van Lier
authors.forename: Hongjian
authors.initials: H
authors.lastname: Tian
authors.forename: Hasrat
authors.initials: H
authors.lastname: Ali
authors.forename: Nicole
authors.initials: N
authors.lastname: Cauchon
authors.forename: Haroutioun M
authors.initials: HM
authors.lastname: Hasséssian
mesh_terms: D000818:Animals; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy; D010211:Papilledema / Q000097:blood / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use*; D011166:Porphyrins / Q000737:chemistry* / Q000627:therapeutic use*; D051381:Rats; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D014867:Water