Esophageal dysmotility in scleroderma: a prospective study of 183 cases.
OBJECTIVE
The goal of the study was to evaluate the prevalence and risk factors of esophageal motor disorders in systemic sclerosis.


METHODS
In 183 consecutive cases of scleroderma, as diagnosed by American College of Rheumatology criteria (1980). Patients' mean age was 40.6+/-13.3 years, the gender ratio was 0.13 and the average duration of disease was 6.8+/-7.5 years. A localized, cutaneous form was observed in 148 patients (81%) and a diffuse form in 35 (19%). All patients underwent upper gastrointestinal endoscopy and standard esophageal manometry.


RESULTS
Esophageal symptoms and reflux esophagitis were found in 108 (59%) and 68 (37%) of patients, respectively. Esophageal motor disorders were present in 148 patients (81%), and were associated with a hypotensive lower esophageal sphincter in 114 (62%). The presence of these motor abnormalities was not related to age, gender, skin extension or duration of disease. Esophageal motor disorders were present in almost all patients with esophageal symptoms or esophagitis, and were also found in 48 (64%) of the asymptomatic patients.


CONCLUSIONS
Esophageal motor disorders are frequently seen in scleroderma, especially in cases with clinical symptoms, but are not associated with a specific form of the disease.
Lahcene
M
M
Service de Médecine Interne, Hôpital Bachir Mentouri, Kouba, Alger, Algeria. lahcenemustapha2005@yahoo.fr
Oumnia
N
N
Matougui
N
N
Boudjella
M
M
Tebaibia
A
A
Touchene
B
B
D000328:Adult; D016099:Endoscopy, Gastrointestinal; D015154:Esophageal Motility Disorders / Q000150:complications* / Q000175:diagnosis; D004942:Esophagitis, Peptic / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012595:Scleroderma, Systemic / Q000150:complications*