title: Heart failure and adverse drug reactions among hospitalized older adults.
abstract: The aim of this study was to assess whether heart failure (HF) could be a risk factor for adverse drug reactions (ADRs) among hospitalized older adults. This study included 19,496 patients admitted to community- and university-based hospitals in Italy (mean age 70 +/- 14 years; 49.7% female). ADRs were identified in 207 of the 2,413 (8.6%) patients with HF and in 855 (5.0%) of the 17,083 patients without HF (P < 0.001). After adjusting for potential confounders, HF was shown to be associated with an increased likelihood of experiencing an ADR (odds ratio (OR) 1.29; 95% confidence interval (CI) 1.06-1.56). After stratifying the sample by gender, the association continued to be seen in the women (OR 1.58; 95% CI 1.22-2.05) but not in the men (OR 0.99; 95% CI 0.74-1.34). In conclusion, HF appears to be associated with a higher rate of ADRs among hospitalized patients. Gender may influence the effect of HF on the risk of ADRs.
authors.affiliation: Department of Geriatrics, Centro Medicina dell'Invecchiamento, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Catananti
authors.forename: R
authors.initials: R
authors.lastname: Liperoti
authors.forename: S
authors.initials: S
authors.lastname: Settanni
authors.forename: F
authors.initials: F
authors.lastname: Lattanzio
authors.forename: R
authors.initials: R
authors.lastname: Bernabei
authors.forename: D
authors.initials: D
authors.lastname: Fialova
authors.forename: F
authors.initials: F
authors.lastname: Landi
authors.forename: G
authors.initials: G
authors.lastname: Onder
mesh_terms: D000368:Aged / Q000502:physiology*; D015992:Body Mass Index; D015331:Cohort Studies; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006333:Heart Failure / Q000453:epidemiology / Q000503:physiopathology*; D006760:Hospitalization; D006801:Humans; D007558:Italy; D008297:Male; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors