Longitudinal 4.0 Tesla (31)P magnetic resonance spectroscopy changes in the anterior cingulate and left thalamus in first episode schizophrenia.
Progressive volumetric losses in schizophrenia may be preceded by abnormal cell membrane metabolism. Longitudinal changes in membrane metabolites were quantified with (31)P MRS in the anterior cingulate and left thalamus of 13 first episode schizophrenic patients and 13 healthy volunteers at baseline and 30 months. Glycerophosphocholine was higher in patients at baseline in the anterior cingulate and glycerophosphoethanolamine was lower in the left thalamus at 30 months compared with patients at baseline and volunteers at 30 months. These observations suggest longitudinal changes in membrane metabolites consistent with a neurodegenerative process in certain cases of schizophrenia.
Miller
Jodi
J
Lawson Health Research Institute, London, Ontario, Canada.
Williamson
Peter
P
Jensen
J Eric
JE
Manchanda
Rahul
R
Menon
Ravi
R
Neufeld
Richard
R
Rajakumar
Nagalingam
N
Pavlosky
William
W
Densmore
Maria
M
Schaefer
Betsy
B
Drost
Dick J
DJ
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D007839:Functional Laterality; D005997:Glycerylphosphorylcholine / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D010714:Phosphatidylethanolamines / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism; D012559:Schizophrenia / Q000175:diagnosis / Q000378:metabolism*; D013788:Thalamus / Q000378:metabolism*; D013997:Time Factors
D010714:Phosphatidylethanolamines; C002449:glycerophosphoethanolamine; D010758:Phosphorus; D005997:Glycerylphosphorylcholine