title: Influence of hydroxypropyl methylcellulose on drug release pattern of a gastroretentive floating drug delivery system using a 3(2) full factorial design.
abstract: In the present investigation, controlled release gastroretentive floating drug delivery system of theophylline was developed employing response surface methodology. A 3(2) randomized full factorial design was developed to study the effect of formulation variables like various viscosity grades and contents of hydroxypropyl methylcellulose (HPMC) and their interactions on response variables. The floating lag time for all nine experimental trial batches were less than 2 min and floatation time of more than 12 h. Theophylline release from the polymeric matrix system followed non-Fickian anomalous transport. Multiple regression analysis revealed that both viscosity and content of HPMC had statistically significant influence on all dependent variables but the effect of these variables found to be nonlinear above certain threshold values.
authors.affiliation: College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa, India. kapina20002000@yahoo.co.in
authors.forename: Kalpana
authors.initials: K
authors.lastname: Swain
authors.forename: Satyanarayan
authors.initials: S
authors.lastname: Pattnaik
authors.forename: Subrata
authors.initials: S
authors.lastname: Mallick
authors.forename: Korla Appana
authors.initials: KA
authors.lastname: Chowdary
mesh_terms: D001993:Bronchodilator Agents / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D015999:Multivariate Analysis; D013607:Tablets / Q000737:chemistry; D013806:Theophylline / Q000737:chemistry*; D013997:Time Factors; D014783:Viscosity
chemical_list: D001993:Bronchodilator Agents; D004337:Drug Carriers; D013607:Tablets; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D013806:Theophylline