Comparative study of the in vitro effect of nanoliposomes with oxidized dextrans on peritoneal cells.
We studied the in vitro effect of hybrid molecular-nanosomal biocompatible compositions on cultured peritoneal cells. The compositions consisted of oxidized dextrans with a mean molecular weight of 35 and 60 kDa, which were obtained by chemical and radiochemical oxidation of dextran. Hybrid nanoliposomal compositions of chemically oxidized dextran (permanganate method) had greater biocompatibility and tropic activity to macrophages compared to nanoliposomes of radiochemically oxidized dextran.
Shkurupiy
V A
VA
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. sck@soramn.ru
Arkhipov
S A
SA
Troitsky
A V
AV
Luzgina
N G
NG
Zaikovskaja
M V
MV
Gulyaeva
E P
EP
Bistrova
T N
TN
Ufimceva
E G
EG
Iljin
D A
DA
Akhramenko
E S
ES
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003911:Dextrans / Q000737:chemistry* / Q000494:pharmacology*; D008081:Liposomes / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D049329:Nanostructures / Q000737:chemistry; D010084:Oxidation-Reduction; D010537:Peritoneum / Q000166:cytology* / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D011854:Radiochemistry; D051381:Rats
D003911:Dextrans; D008081:Liposomes