Synthesis of novel ribavirin hydrazone derivatives and anti-proliferative activity against A549 lung cancer cells.
A series of novel ribavirin hydrazone derivatives were synthesized by the reaction of ribavirin hydrazone with benzaldehyde or acetophenone derivatives. The structures of the compounds were determined by IR, (1)H NMR, and HRESIMS. Preliminary biological evaluation showed that one compound (7h) inhibits the growth of A549 cells at 20microM.
Liu
Wei-Yong
WY
Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
Li
Hai-Ying
HY
Zhao
Bao-Xiang
BX
Shin
Dong-Soo
DS
Lian
Song
S
Miao
Jun-Ying
JY
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000473:pathology*; D012254:Ribavirin / Q000031:analogs & derivatives*
D000970:Antineoplastic Agents; D006835:Hydrazones; D012254:Ribavirin