Circulating TGF-beta1 as a reliable biomarker for chronic kidney disease progression in the African-American population.
Progressive renal fibrosis is common to all chronic kidney diseases (CKD). Suthanthiran and colleagues identified a positive association between transforming growth factor-beta1 and several risk factors for CKD progression in African Americans but not in whites. This study offers a possible explanation for the higher prevalence of end-stage renal disease in African Americans and highlights the need for a better therapeutic strategy for this population.
Lee
Soo Bong
SB
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
Kanasaki
Keizo
K
Kalluri
Raghu
R
D001741:Black or African American / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000208:ethnology*; D008954:Models, Biological; D044382:Population Groups / Q000706:statistics & numerical data*; D015995:Prevalence; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D014481:United States / Q000453:epidemiology
D015415:Biomarkers; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1