[Characteristics of autoimmune reactions in chronic cardiac failure of different etiology].
OBJECTIVE
To characterize autoimmune reactions in patients with chronic cardiac failure (CCF) of different etiology.


METHODS
Basic markers of immune activation were measured in 43 patients with coronary heart disease stage I-IIB (NYHA FC I-IV) and 44 patients with dilated cardiomyopathy (DCMP) stage I-IIB (NYHA FC I-IV). Antibodies to myocardial tissue were studied with indirect immunofluorescence. Echocardiography was made by standard recommendations with evaluation of systolic and diastolic left ventricular function. Concentrations of C-reactive protein, IgG, IgA, IgM were estimated nephelometrically. Enzyme immunoassay studied serum levels of IL-8, IL-2R, IL-6, IL-18, IL-10, IFN-gamma, endothelin.


RESULTS
Patients with DCMP had higher titers of antimyocardial autoantibodies than in coronary heart disease (CHD) reflecting more severe autoimmune inflammation. In CHD endothelial, systolic and diastolic dysfunctions severity correlated with severity of inflammation.


CONCLUSIONS
Some characteristics of autoimmune reactions in CCF determine severity of the disease course.
Zykov
K A
KA
Tatenkulova
S N
SN
Masenko
V P
VP
Kuznetsova
T V
TV
Rvacheva
A V
AV
Belenkov
Iu N
IuN
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D015551:Autoimmunity; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D002908:Chronic Disease; D004452:Echocardiography; D016232:Endothelins / Q000097:blood; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006333:Heart Failure / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D007378:Interleukins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000276:immunology*; D012720:Severity of Illness Index; D016277:Ventricular Function, Left / Q000502:physiology; D055815:Young Adult
D001323:Autoantibodies; D016232:Endothelins; D007378:Interleukins; D007371:Interferon-gamma