title: Structural and functional diversity among eukaryotic Hsp70 nucleotide exchange factors.
abstract: Since their recent identification, eukaryotic Hsp70 nucleotide exchange factors (NEFs) have gained increasing interest due to their engagement in vital cellular processes. Here, I summarize our current knowledge of their mechanisms of action, regulations and cellular functions as well as their relevance for human diseases such as cystic fibrosis or amyloidoses.
authors.affiliation: Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, 91198 Gif-sur-Yvette, France. Mehdi.Kabani@lebs.cnrs-gif.fr
authors.forename: Mehdi
authors.initials: M
authors.lastname: Kabani
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D009711:Nucleotides / Q000378:metabolism*
chemical_list: D018840:HSP70 Heat-Shock Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009711:Nucleotides