[Detection rate of MAGE-A1-A6 mRNA in the peripheral blood of cancer patients].
The mRNA expression of 6 MAGE-A (MAGE-A1-A6) antigens by the tumor focal cells and cancer cells circulating in blood was studied in solid malignant and benign neoplasms. MAGE- A1-A6 mRNA expression was detected in the tumor focal cells in more than 90% of cases of cancer of the breast, lung, and stomach and melanoma cell lines. The detection rate of peripheral blood MAGE-A1-A6-positive tumor cells was 95% in lung cancer, 53% in corpus uteri cancer, 67% in gastric cancer, 63% in breast cancer, 33% in melanoma, and 42% in uterine myoma. MAGE-A3 and MAGE-A4 mRNA expression was more commonly observed.
Novikov
D V
DV
Belova
T V
TV
Pegov
R G
RG
Aliasova
A A
AA
Morozova
P N
PN
Kniazev
D I
DI
Kalugin
A V
AV
Kontorshchikova
K N
KN
Baryshnikov
A Iu
AIu
Novikov
V V
VV
D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000097:blood; D009369:Neoplasms / Q000097:blood; D009360:Neoplastic Cells, Circulating / Q000378:metabolism*; D012333:RNA, Messenger / Q000097:blood*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C072013:MAGEA3 protein, human; C095204:MAGEA4 protein, human; C095203:MAGEA6 protein, human; C420909:Mage-a2 antigen; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D012333:RNA, Messenger