title: Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism.
abstract: During and after prolonged bed rest, changes in bone metabolic markers occur within 3 days. Resistive vibration exercise during bed rest impedes bone loss and restricts increases in bone resorption markers whilst increasing bone formation.
  
  
  BACKGROUND
  To investigate the effectiveness of a resistive vibration exercise (RVE) countermeasure during prolonged bed rest using serum markers of bone metabolism and whole-body dual X-ray absorptiometry (DXA) as endpoints.
  
  
  METHODS
  Twenty healthy male subjects underwent 8 weeks of bed rest with 12 months follow-up. Ten subjects performed RVE. Blood drawings and DXA measures were conducted regularly during and after bed rest.
  
  
  RESULTS
  Bone resorption increased in the CTRL group with a less severe increase in the RVE group (p = 0.0004). Bone formation markers increased in the RVE group but decreased marginally in the CTRL group (p < 0.0001). At the end of bed rest, the CTRL group showed significant loss in leg bone mass (-1.8(0.9)%, p = 0.042) whereas the RVE group did not (-0.7(0.8)%, p = 0.405) although the difference between the groups was not significant (p = 0.12).
  
  
  CONCLUSIONS
  The results suggest the countermeasure restricts increases in bone resorption, increased bone formation, and reduced bone loss during bed rest.
authors.affiliation: Zentrum für Muskel- und Knochenforschung, Charité Campus Benjamin Franklin, Berlin, Germany. gabi.armbrecht@charite.de
authors.forename: G
authors.initials: G
authors.lastname: Armbrecht
authors.forename: D L
authors.initials: DL
authors.lastname: Belavý
authors.forename: U
authors.initials: U
authors.lastname: Gast
authors.forename: M
authors.initials: M
authors.lastname: Bongrazio
authors.forename: F
authors.initials: F
authors.lastname: Touby
authors.forename: G
authors.initials: G
authors.lastname: Beller
authors.forename: H J
authors.initials: HJ
authors.lastname: Roth
authors.forename: F H
authors.initials: FH
authors.lastname: Perschel
authors.forename: J
authors.initials: J
authors.lastname: Rittweger
authors.forename: D
authors.initials: D
authors.lastname: Felsenberg
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D001510:Bed Rest / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001823:Body Composition; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000652:urine; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009133:Muscular Atrophy / Q000209:etiology / Q000517:prevention & control*; D055070:Resistance Training / Q000379:methods*; D014732:Vibration / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D002118:Calcium