title: Investigation of changes in NO content during long-term sensitization in edible snail using EPR-spectroscopy: effects of antibodies to calcium-binding protein S-100.
abstract: EPR-spectroscopy experiments (electron paramagnetic resonance) demonstrated a decrease in NO production in the nervous system and heart of edible snail Helix lucorum after formation of long-term sensitization, a neurobiological model of anxiety and depression. The protective effect of antibodies to Ca(2+)-binding protein S-100 in dilution of 10(-12) on the formation of long-term sensitization was accompanied by partial recovery of NO synthesis in the nervous system and heart. These findings indicate that the imbalance in Ca(2+)-binding protein S-100 can lead to inhibition or modulation of some processes during plastic reorganization in the body and especially during pathological processes.
authors.affiliation: E. K. Zavoiskii Kazan' Physicotechnical Institute, Russian Academy of Sciences, Novosibirsk, Russia. gainutdinov@mail.knc.ru
authors.forename: Kh L
authors.initials: KhL
authors.lastname: Gainutdinov
authors.forename: V V
authors.initials: VV
authors.lastname: Andrianov
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Gainutdinova
authors.forename: L N
authors.initials: LN
authors.lastname: Muranova
authors.forename: A A
authors.initials: AA
authors.lastname: Obynochny
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Timoshenko
authors.forename: M B
authors.initials: MB
authors.lastname: Shtark
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
authors.forename: S V
authors.initials: SV
authors.lastname: Yurtaeva
authors.forename: G G
authors.initials: GG
authors.lastname: Jafarova
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism*; D009418:S100 Proteins / Q000276:immunology*
chemical_list: D000906:Antibodies; D009418:S100 Proteins; D009569:Nitric Oxide