Antiarrhythmic activity of phytoadaptogens in short-term ischemia-reperfusion of the heart and postinfarction cardiosclerosis.
A course of treatment (16 mg/kg orally during 5 days) by Aralia mandshurica or Rhodiola rosea extracts reduced the incidence of ischemic and reperfusion ventricular arrhythmias during 10-min ischemia and 10-min reperfusion. Extracts of Eleutherococcus senticosus, Leuzea carthamoides, and Panax ginseng did not change the incidence of ischemic and reperfusion arrhythmias. Chronic treatment by aralia, rhodiola, and eleutherococcus elevated the ventricular fibrillation threshold in rats with postinfarction cardiosclerosis. Ginseng and leuzea did not change this parameter in rats with postinfarction cardiosclerosis.
Maslov
L N
LN
Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. maslov@cardio.tsu.ru
Lishmanov
Yu B
YB
Arbuzov
A G
AG
Krylatov
A V
AV
Budankova
E V
EV
Konkovskaya
Yu N
YN
Burkova
V N
VN
Severova
E A
EA
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000627:therapeutic use*; D027983:Aralia / Q000737:chemistry; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D028001:Eleutherococcus / Q000737:chemistry; D043843:Leuzea / Q000737:chemistry; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D005894:Panax / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D029771:Rhodiola / Q000737:chemistry; D014693:Ventricular Fibrillation / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D010936:Plant Extracts