Expanding RNA silencing approaches by U1 adaptors.
Silent partner: In a recent publication, Gunderson and co-workers described an approach to recruit the abundant U1 snRNP, a splicing subparticle, to the last exon of a pre-mRNA, in a sequence-specific manner. This mediates interaction of the U1-70K protein subunit with poly(A) polymerase, thus blocking polyadenylation and inducing pre-mRNA degradation. This novel promising strategy expands the repertoire of gene-silencing concepts.
Grünweller
Arnold
A
Pharmaceutical Chemistry, Philipps-Universität Marburg, Marbacher Weg 6, Marburg, Germany.
Hartmann
Roland K
RK
D001483:Base Sequence; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D011062:Polynucleotide Adenylyltransferase / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000378:metabolism*
D012322:RNA Precursors; D017412:Ribonucleoprotein, U1 Small Nuclear; D011062:Polynucleotide Adenylyltransferase