A multicenter study on optimizing piperacillin-tazobactam use: lessons on why interventions fail.
We examined interventions to optimize piperacillin-tazobactam use at 4 hospitals. Interventions for rotating house staff did not affect use. We could target empiric therapy in only 35% of cases. Because prescribing practices seemed to be institution specific, interventions should address attitudes of local prescribers. Interventions should target empiric therapy and ordering of appropriate cultures.
Gaynes
Robert P
RP
Centers for Disease Control and Prevention, Emory University School of Medicine, Atlanta Veterans' Affairs Medical Center, GA, USA. rgaynes@cdc.gov
Gould
Carolyn V
CV
Edwards
Jonathan
J
Antoine
Theresa L
TL
Blumberg
Henry M
HM
Desilva
Kathryn
K
King
Mark
M
Kraman
Alice
A
Pack
Jan
J
Ribner
Bruce
B
Seybold
Ulrich
U
Steinberg
James
J
Jernigan
John A
JA
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D024881:Drug Resistance, Bacterial; D004363:Drug Utilization / Q000706:statistics & numerical data; D017144:Focus Groups; D007722:Health Knowledge, Attitudes, Practice; D006785:Hospitals, University; D006787:Hospitals, Veterans; D006801:Humans; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D010878:Piperacillin / Q000627:therapeutic use; D000077725:Piperacillin, Tazobactam Drug Combination; D010818:Practice Patterns, Physicians'
D000900:Anti-Bacterial Agents; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin