title: Vitamin K epoxide reductase complex 1 (VKORC1) haplotypes in healthy Hungarian and Roma population samples.
abstract: The aim of this work was to determine the VKORC1 haplotype profile in healthy Hungarian and Roma population samples, and to compare our data with other selected populations. Using haplotype tagging SNPs (G-1639A, G9041A and C6009T), we characterized Hungarian (n = 510) and Roma (n = 451) population samples with regard to VKORC1*1, *2, *3 and *4 haplotypes. In the Hungarian samples, the VKORC1*1, *2, *3 and *4 haplotypes accounted for 3, 39, 37 and 21%, respectively and by contrast, in the Roma population samples the VKORC1 variants were 5, 30, 46 and 19%, respectively. Comparing the genotypes of Roma and Hungarian populations, difference was found in the *2/*2 (6.87 vs 13.5%), *2/*4 (13.9 vs 19.2%) and *3*3 (21.9 vs 13.7%) VKORC1 haplotype combinations. Comparing each group with the others, and our data with findings published previously by other groups, the VKORC1 genetic profile in Hungarians was more similar to European Caucasians and Americans with European descent than to Roma samples. Clear differences could be detected between Roma versus Hungarians and European or American Caucasians; the Roma population had only minor similarities with data from India.
authors.affiliation: University of Pecs, Department of Medical Genetics and Child Development, H-7624 Pecs, Szigeti 12, Hungary.
authors.forename: Csilla
authors.initials: C
authors.lastname: Sipeky
authors.forename: Veronika
authors.initials: V
authors.lastname: Csongei
authors.forename: Luca
authors.initials: L
authors.lastname: Jaromi
authors.forename: Eniko
authors.initials: E
authors.lastname: Safrany
authors.forename: Noemi
authors.initials: N
authors.lastname: Polgar
authors.forename: Lilla
authors.initials: L
authors.lastname: Lakner
authors.forename: Melinda
authors.initials: M
authors.lastname: Szabo
authors.forename: Istvan
authors.initials: I
authors.lastname: Takacs
authors.forename: Bela
authors.initials: B
authors.lastname: Melegh
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups / Q000235:genetics; D064417:Vitamin K Epoxide Reductases; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D004247:DNA; D006899:Mixed Function Oxygenases; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases