title: Diffuse chronic leptomeningitis with seropositive rheumatoid arthritis: report of a case successfully treated as rheumatoid leptomeningitis.
abstract: A case of biopsy-confirmed chronic leptomeningitis complicating rheumatoid arthritis in a 53-year old female is reported. Her symptoms included weight loss, severe depression, and pyrexia. Magnetic resonance imaging was useful in diagnosis. Intravenous methylprednisolone was prescribed (1 g/day for 3 days), followed by prednisolone (initial dose of 30 mg daily), and this treatment was effective. Her IgG-index, serum levels of soluble interleukin-2 receptor and ferritin, and cerebrospinal level of interleukin-6 paralleled her clinical course.
authors.affiliation: Department of Rheumatology, National Hospital Organization Sagamihara Hospital, 18-1 Sakura-dai, Sagamihara, Kanagawa, 228-8522, Japan. k-shimada@sagamihara-hosp.gr.jp
authors.forename: Kota
authors.initials: K
authors.lastname: Shimada
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Matsui
authors.forename: Misato
authors.initials: M
authors.lastname: Kawakami
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Futami
authors.forename: Kazuya
authors.initials: K
authors.lastname: Michishita
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takaoka
authors.forename: Tatsuoh
authors.initials: T
authors.lastname: Ikenaka
authors.forename: Akiko
authors.initials: A
authors.lastname: Komiya
authors.forename: Hisanori
authors.initials: H
authors.lastname: Nakayama
authors.forename: Futoshi
authors.initials: F
authors.lastname: Hagiwara
authors.forename: Shoji
authors.initials: S
authors.lastname: Sugii
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ozawa
authors.forename: Shigeto
authors.initials: S
authors.lastname: Tohma
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D001921:Brain / Q000473:pathology; D002908:Chronic Disease / Q000188:drug therapy; D016207:Cytokines / Q000097:blood; D018450:Disease Progression; D004334:Drug Administration Schedule; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D008279:Magnetic Resonance Imaging; D008581:Meningitis / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010841:Pia Mater / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D015375:Receptors, Interleukin-2; D005293:Ferritins; D011239:Prednisolone; D008775:Methylprednisolone