title: [Structural-functional study of glycine-and-proline-containing peptides (glyprolines) as potential neuroprotectors].
abstract: A synthetic scheme for preparation of (Gly-Pro)n, (Pro-Gly)n (n = 2, 3), and (Pro-Gly-Pro)n (n = 1, 2) peptides was elaborated. The effect of the synthesized peptides and the Gly-Pro and Pro-Gly dipeptides on survival of cultured cells of PC12 rat pheochromocytoma was studied under the conditions of oxidative stress induced by brief incubation of the cells with hydrogen peroxide. Peptides of the general formula (Gly-Pro)n and the Pro-Gly-Pro peptide at a concentration of 0.2-100 microM were shown to decrease the number of damaged cells. The Gly-Pro peptide was the most active and decreased the number of damaged cells by 49% on average at a concentration of 100 microM.
authors.forename: K V
authors.initials: KV
authors.lastname: Martynova
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: P A
authors.initials: PA
authors.lastname: Klimova
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Kirillova
authors.forename: V P
authors.initials: VP
authors.lastname: Shevchenko
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Nagaev
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Shram
authors.forename: V I
authors.initials: VI
authors.lastname: Shvets
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006861:Hydrogen Peroxide / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D016716:PC12 Cells; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D018696:Neuroprotective Agents; D016877:Oxidants; D010455:Peptides; D006861:Hydrogen Peroxide