title: Effect of exercise training on cardiometabolic risk markers among sedentary, but metabolically healthy overweight or obese post-menopausal women with elevated blood pressure.
abstract: OBJECTIVE
  To investigate the effect of exercise training on markers of the lipoprotein-lipid profile and inflammatory markers in post-menopausal overweight/obese women with a moderately elevated systolic blood pressure.
  
  
  METHODS
  A total of 267 women [mean body mass index (BMI)=32.0+/-5.7kg/m(2) and mean age=57.3+/-6.6 years] underwent a 6-month exercise intervention program. Exercise training was performed 3-4 times per week at a targeted heart rate corresponding to 50% of the maximal oxygen consumption.
  
  
  RESULTS
  Compared to baseline values, mean change in relative VO(2) max (the primary endpoint) was of 1.18+/-2.25mL/minkg (p<0.0001), mean weight loss was of 1.4+/-3.3kg (p<0.0001), mean reduction in waist circumference was of 2.4+/-6.9cm (p<0.0001) and systolic blood pressure did not change significantly (-1.2+/-13.0mmHg, NS). No changes were observed in markers of the lipoprotein-lipid profile. No changes were observed for plasma levels of C-reactive protein, interleukin-6, tumor-necrosis factor-alpha and adiponectin. Changes in VO(2) max were negatively associated with changes in body weight (r=-0.26, p<0.0001) and waist circumference (r=-0.16, p=0.01), but not with changes in cardiometabolic risk markers.
  
  
  CONCLUSIONS
  Although exercise training significantly increased cardiorespiratory fitness in these sedentary, but metabolically healthy obese/overweight women with a moderately elevated systolic blood pressure, no significant improvements were observed in their cardiometabolic risk profile.
authors.affiliation: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada.
authors.forename: Benoit J
authors.initials: BJ
authors.lastname: Arsenault
authors.forename: Mélanie
authors.initials: M
authors.lastname: Côté
authors.forename: Amélie
authors.initials: A
authors.lastname: Cartier
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lemieux
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Després
authors.forename: Robert
authors.initials: R
authors.lastname: Ross
authors.forename: Conrad P
authors.initials: CP
authors.lastname: Earnest
authors.forename: Steven N
authors.initials: SN
authors.lastname: Blair
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Church
mesh_terms: D052242:Adiponectin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D050177:Overweight / Q000150:complications / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D010101:Oxygen Consumption; D010809:Physical Fitness; D017698:Postmenopause; D011446:Prospective Studies; D012307:Risk Factors; D057185:Sedentary Behavior; D013997:Time Factors; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055105:Waist Circumference; D015431:Weight Loss
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D008055:Lipids; D008074:Lipoproteins; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein