title: Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol.
abstract: To study the potential for delayed Type IV dermal sensitivity of a new preservative system containing 1,2-hexanediol and caprylyl glycol, 200-subject repeat insult patch tests were performed with a 15% mixture of 1,2-hexanediol and caprylyl glycol (equal parts of the 2 ingredients) in carbomer gel and a cosmetic formulation at an actual use concentration. No delayed Type IV hypersensitivity reactions were observed.
authors.affiliation: Revlon Research Center, Edison, New Jersey, USA. slevy@mindspring.com
authors.forename: Stanley B
authors.initials: SB
authors.lastname: Levy
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Dulichan
authors.forename: Michael
authors.initials: M
authors.lastname: Helman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003257:Consumer Product Safety; D003358:Cosmetics / Q000633:toxicity; D004487:Edema / Q000139:chemically induced*; D004890:Erythema / Q000139:chemically induced*; D005260:Female; D006018:Glycols / Q000633:toxicity*; D006586:Hexanes; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D000442:Octanols / Q000633:toxicity*; D010328:Patch Tests; D011310:Preservatives, Pharmaceutical / Q000633:toxicity*; D055815:Young Adult
chemical_list: D003358:Cosmetics; D006018:Glycols; D006586:Hexanes; D000442:Octanols; D011310:Preservatives, Pharmaceutical; C535047:1,2-octanediol; C119102:1,2-hexanediol