title: A current practice for predicting ocular toxicity of systemically delivered drugs.
abstract: The ability to predict ocular side effects of systemically delivered drugs is an important issue for pharmaceutical companies. Although animal models involving standard clinical ophthalmic examinations and postmortem microscopic examinations of eyes are still used to identify ocular issues, these methods are being supplemented with additional in silico, in vitro, and in vivo techniques to identify potential safety issues and assess risk. The addition of these tests to a development plan for a potential new drug provides the opportunity to save time and money by detecting ocular issues earlier in the program. This review summarizes a current practice for minimizing the potential for systemically administered, new medicines to cause adverse effects in the eye.
authors.affiliation: Drug Safety Research & Development, Pfizer Global R & D, Groton, CT 06340, USA. christopher.j.somps@pfizer.com
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Somps
authors.forename: Nigel
authors.initials: N
authors.lastname: Greene
authors.forename: James A
authors.initials: JA
authors.lastname: Render
authors.forename: Michael D
authors.initials: MD
authors.lastname: Aleo
authors.forename: Jay H
authors.initials: JH
authors.lastname: Fortner
authors.forename: James A
authors.initials: JA
authors.lastname: Dykens
authors.forename: Gareth
authors.initials: G
authors.lastname: Phillips
mesh_terms: D000818:Animals; D001681:Biological Assay; D002784:Cholesterol / Q000096:biosynthesis; D003941:Diagnostic Techniques, Ophthalmological; D064420:Drug-Related Side Effects and Adverse Reactions; D005123:Eye / Q000187:drug effects*; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism; D013329:Structure-Activity Relationship; D018675:Toxicity Tests
chemical_list: D002784:Cholesterol