title: Seminal vesicle invasion in prostate cancer: prediction with combined T2-weighted and diffusion-weighted MR imaging.
abstract: The aim of this study was to evaluate the usefulness of diffusion-weighted imaging (DWI) in detecting seminal vesicle invasion (SVI). A total of 283 patients underwent conventional MRI and DWI before prostate cancer surgery. The apparent diffusion coefficient (ADC) values of all PCa foci, SVI and seminal vesicle were measured. T2 images alone and then T2 images combined with DWI were scored for the likelihood of SVI. The area under the receiver operating characteristic curve (AUC) was used to assess accuracy. Statistical significance was inferred at P < 0.05. On pathological analysis, 39 patients had SVI. The ADC values of SVI were significantly lower than those of SV. The AUC for T2-weighted imaging plus DW imaging (0.897) was significantly larger (P < 0.05) than that for T2-weighted imaging alone (0.779). T2 images combined with DWI shows significantly higher accuracy than T2-weighted imaging alone in the detection of SVI.
authors.affiliation: Department of Radiology, Xijing Hospital, Fourth Military Medical University, Chang Le Western Road No. 15, Xi'an, 710032, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ren
authors.forename: Yi
authors.initials: Y
authors.lastname: Huan
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: YaLi
authors.initials: Y
authors.lastname: Ge
authors.forename: YingJuan
authors.initials: Y
authors.lastname: Chang
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
authors.forename: LiJun
authors.initials: L
authors.lastname: Sun
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology*; D015203:Reproducibility of Results; D012669:Seminal Vesicles / Q000473:pathology*; D012680:Sensitivity and Specificity; D013382:Subtraction Technique