[NADPH oxidase and male erectile dysfunction].
Erectile dysfunction (ED) is a common disease in men. Oxidative stress is indicated to be one of the important mechanisms of ED. NADPH oxidase expresses and plays significant psychological functions in many human organs, including the penis. In a variety of pathophysiological conditions, NADPH oxidase causes excessive oxidative stress through overproducing reactive oxygen species in the penis, and consequently induces erectile dysfunction. This paper reviews the composition, homologues, activation and physiological functions of NADPH oxidase, its role in ED, and its application in the treatment of ED.
Rao
Ke
K
Department of Urology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Liu
Ji-Hong
JH
D007172:Erectile Dysfunction / Q000201:enzymology* / Q000628:therapy; D006801:Humans; D008297:Male; D019255:NADPH Oxidases / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species
D017382:Reactive Oxygen Species; D019255:NADPH Oxidases