title: Acellular dermal matrix as a barrier in guided bone regeneration: a clinical, radiographic and histomorphometric study in dogs.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effectiveness of the acellular dermal matrix (ADM) as a membrane for guided bone regeneration (GBR), in comparison with a bioabsorbable membrane.
  
  
  METHODS
  In seven dogs, the mandibular pre-molars were extracted. After 8 weeks, one bone defect was surgically created bilaterally and the GBR was performed. Each side was randomly assigned to the control group (CG: bioabsorbable membrane made of glycolide and lactide copolymer) or the test group (TG: ADM as a membrane). Immediately following GBR, standardized digital X-ray radiographs were taken, and were repeated at 8 and 16 weeks post-operatively. Before the GBR and euthanasia, clinical measurements of the width and thickness of the keratinized tissue (WKT and TKT, respectively) were performed. One animal was excluded from the study due to complications in the TG during wound healing; therefore, six dogs remained in the sample. The dogs were sacrificed 16 weeks following GBR, and a histomorphometric analysis was performed. Area measurements of new tissue and new bone, and linear measurements of bone height were performed.
  
  
  RESULTS
  Post-operative healing of the CG was uneventful. In the TG membrane was exposed in two animals, and one of them was excluded from the sample. There were no statistically significant differences between the groups for any histomorphometric measurement. Clinically, both groups showed an increase in the TKT and a reduction in the WKT. Radiographically, an image suggestive of new bone formation could be observed in both groups at 8 and 16 weeks following GBR.
  
  
  CONCLUSIONS
  ADM acted as a barrier in GBR, with clinical, radiographic and histomorphometric results similar to those obtained with the bioabsorbable membrane.
authors.affiliation: Department of Surgery, Oral-Maxillo-Facial Traumatology and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, SP, Brazil.
authors.forename: Germana Jayme
authors.initials: GJ
authors.lastname: Borges
authors.forename: Arthur Belém
authors.initials: AB
authors.lastname: Novaes
authors.forename: Márcio Fernando de Moraes
authors.initials: MF
authors.lastname: Grisi
authors.forename: Daniela Bazan
authors.initials: DB
authors.lastname: Palioto
authors.forename: Mário
authors.initials: M
authors.lastname: Taba
authors.forename: Sérgio Luís Scombatti
authors.initials: SL
authors.lastname: de Souza
mesh_terms: D020341:Absorbable Implants; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000502:physiology; D003094:Collagen / Q000627:therapeutic use; D004285:Dogs; D005109:Extracellular Matrix; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D020007:Implants, Experimental; D008297:Male; D008334:Mandible; D008567:Membranes, Artificial; D011897:Random Allocation; D017768:Skin, Artificial; D054457:Tissue Scaffolds; D014945:Wound Healing / Q000502:physiology
chemical_list: C440568:Alloderm; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D003094:Collagen