Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease.
Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage.
Chen
Xiaoqiang
X
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China.
Fan
Jiangli
J
Peng
Xiaojun
X
Wang
Jingyun
J
Sun
Shiguo
S
Zhang
Rong
R
Wu
Tong
T
Zhang
Fei
F
Liu
Jianfeng
J
Wang
Fen
F
Ma
Saijian
S
D000166:Acridines / Q000737:chemistry*; D002384:Catalysis; D002621:Chemistry / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004247:DNA / Q000737:chemistry; D003851:Deoxyribonucleases / Q000737:chemistry*; D015195:Drug Design; D004587:Electrophoresis, Agar Gel / Q000379:methods; D006868:Hydrolysis; D007364:Intercalating Agents / Q000494:pharmacology; D007501:Iron / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D010957:Plasmids / Q000378:metabolism
D000166:Acridines; D007364:Intercalating Agents; D004247:DNA; D007501:Iron; D003851:Deoxyribonucleases