CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.
CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-kappaB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.
Beswick
Ellen J
EJ
Department of Pediatrics, Children's Hospital, University of Texas Medical Branch, Galveston, TX 77555, United States. ejbeswic@utmb.edu
Reyes
Victor E
VE
D017951:Antigen Presentation / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology*; D005770:Gastrointestinal Neoplasms / Q000276:immunology*; D016481:Helicobacter Infections / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D016209:Interleukin-8 / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology; D020033:Protein Isoforms / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology
D000944:Antigens, Differentiation, B-Lymphocyte; D000949:Histocompatibility Antigens Class II; D016209:Interleukin-8; D008263:Macrophage Migration-Inhibitory Factors; D020033:Protein Isoforms; C045084:invariant chain