Differential phosphorylation of occludin and tricellulin by CK2 and CK1.
In epithelial and endothelial cell layers tight junctions form selective apicolateral paracellular barriers separating luminal and extracellular spaces from the underlying tissues. Within the tight junctions the tetraspan transmembrane proteins occludin, claudins, and tricellulin form anastomosing strands of protein complexes, which interconnect opposing membranes of neighboring cells. Phosphorylation of tight junction components is critically involved in the regulation of tight junction assembly, maintenance, and function. This chapter compares occludin and tricellulin phosphorylation by the serine/threonine kinases CK2 and CK1.
Dörfel
Max J
MJ
Department of Laboratory Medicine and Pathobiochemistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Westphal
Julie K
JK
Huber
Otmar
O
D047389:Casein Kinase I / Q000378:metabolism*; D047390:Casein Kinase II / Q000378:metabolism*; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D062794:MARVEL Domain Containing 2 Protein; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D062793:Occludin; D010766:Phosphorylation; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism
D062794:MARVEL Domain Containing 2 Protein; C516798:MARVELD2 protein, human; D008565:Membrane Proteins; C568985:OCLN protein, human; D062793:Occludin; D011994:Recombinant Proteins; D047389:Casein Kinase I; D047390:Casein Kinase II