Target-selective degradation of cancer-related proteins by novel photosensitizers for molecular-targeted photodynamic therapy.
Proteins are key players in many biological events including cancers. The development of novel photosensitizers for the selective degradation of cancer-related proteins has attracted much attention in the fields of photodynamic therapy for various cancers. In this review article, several novel photosensitizers, which selectively degrade cancer-related proteins under photoirradiation and mild conditions without any further additives, are introduced. This novel class of photosensitizers promises bright prospects for finding molecular-targeted drugs for cancer photodynamic therapy in the near future.
Toshima
Kazunobu
K
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Kohoku-ku Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp
Tanimoto
Shuho
S
Tsumura
Kana
K
Umezawa
Kazuo
K
Takahashi
Daisuke
D
D000818:Animals; D006801:Humans; D008027:Light; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*
D009363:Neoplasm Proteins; D017319:Photosensitizing Agents