Specific effects of single antioxidants in the lipid peroxidation caused by nano-titania used in sunscreen lotions.
The effect of some additives, phenylalanine, ascorbyl palmitate and sodium ascorbyl phosphate on the oxidation of linoleic acid and porcine ear skin induced by UV irradiation was investigated, in the absence and in the presence of variously uncoated and coated titania powders. Such additives have, on the one hand, a scavenging activity toward the oxidizing species photogenerated by TiO(2), and on the other one an inhibitory effect toward UVB-induced peroxidation. Sodium ascorbyl phosphate and ascorbyl palmitate displayed a stronger antioxidant effect than phenylalanine toward linoleic acid peroxidation. On porcine skin all the three molecules exhibited both antiradical and antioxidant activity. Their protective effect against peroxidation was higher with porcine skin lipids than with linoleic acid, referable to the chemical differences in the two lipid substrates.
Carlotti
Maria Eugenia
ME
Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Torino, Italy. eugenia.carlotti@unito.it
Ugazio
Elena
E
Gastaldi
Lucia
L
Sapino
Simona
S
Vione
Davide
D
Fenoglio
Ivana
I
Fubini
Bice
B
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002400:Cathartics / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D053758:Nanoparticles; D010649:Phenylalanine / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D011208:Powders; D012867:Skin / Q000528:radiation effects; D013473:Sunscreening Agents / Q000494:pharmacology*; D013499:Surface Properties; D013552:Swine; D014025:Titanium / Q000494:pharmacology*; D014466:Ultraviolet Rays
D000975:Antioxidants; D002400:Cathartics; D010710:Phosphates; D011208:Powders; D013473:Sunscreening Agents; C009495:titanium dioxide; D010649:Phenylalanine; D014025:Titanium; C018279:sodium phosphate