Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria.
Antibiotic resistance and virulence of pathogenic mycobacteria are phenotypically associated, but the underlying genetic linkage has not been known. Here we show that PknG, a eukaryotic-type protein kinase previously found to support survival of mycobacteria in host cells, is required for the intrinsic resistance of mycobacterial species to multiple antibiotics.
Wolff
Kerstin A
KA
Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Wood Building, 10900 Euclid Avenue, Cleveland, OH 44106-4960, USA.
Nguyen
Hoa T
HT
Cartabuke
Richard H
RH
Singh
Ajay
A
Ogwang
Sam
S
Nguyen
Liem
L
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015153:Blotting, Western; D017869:Cyclic GMP-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism*; D004352:Drug Resistance, Microbial / Q000235:genetics*; D009161:Mycobacterium / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D010588:Phagosomes / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D017869:Cyclic GMP-Dependent Protein Kinases