Intracellular life of Coxiella burnetii in macrophages.
Coxiella burnetii, the agent of Q fever, is an obligate intracellular bacterium that is considered a potential biological weapon of category B. C. burnetii survives within myeloid cells by subverting receptor-mediated phagocytosis and preventing phagosome maturation. The intracellular fate of C. burnetii also depends on the functional state of myeloid cells. This review describes the mechanisms used by C. burnetii to circumvent uptake and trafficking events, and the role of cytokines on C. burnetii survival in myeloid cells.
Ghigo
Eric
E
URMITE CNRS UMR 6236 - IRD 3R198, Institut Fédératif de Recherche 48, Université de la Méditerranée, Marseille, France. Eric.Ghigo@univmed.fr
Pretat
Lionel
L
Desnues
Benoît
B
Capo
Christian
C
Raoult
Didier
D
Mege
Jean-Louis
JL
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D016997:Coxiella burnetii / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D016207:Cytokines / Q000276:immunology; D003599:Cytoskeleton / Q000378:metabolism; D006099:Granuloma / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D006801:Humans; D016023:Integrins / Q000378:metabolism; D016753:Interleukin-10 / Q000276:immunology; D008264:Macrophages / Q000166:cytology / Q000378:metabolism / Q000382:microbiology*; D022423:Myeloid Cells / Q000166:cytology / Q000378:metabolism / Q000382:microbiology; D010587:Phagocytosis / Q000502:physiology; D010588:Phagosomes / Q000378:metabolism* / Q000382:microbiology; D011778:Q Fever / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000635:transmission; D051193:Toll-Like Receptors / Q000276:immunology; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D016207:Cytokines; D016023:Integrins; D051193:Toll-Like Receptors; D037521:Virulence Factors; D016753:Interleukin-10