title: Linear hypopigmentation and cutaneous atrophy following intra-articular steroid injections for de Quervain's tendonitis.
abstract: Intralesional and intra-articular corticosteroids are commonly used therapies in the fields of dermatology, orthopedic surgery and rheumatology. The authors present the case of a 32-year-old female who received intra-articular corticosteroids for de Quervain's tendonitis and developed bilateral hypopigmented patches near the areas of injection. Unilateral linear extension of the hypopigmentation was subsequently noted, presumably secondary to venous or lymphatic uptake of corticosteroid crystals. The patient complained of temperature sensitivity and increased skin fragility affecting all of the hypopigmented areas. A biopsy was performed and MART-1 immunostaining revealed intact melanocytes along the dermal-epidermal junction. The mechanism of corticosteroid-induced hypopigmentation is not well understood, but this biopsy finding supports a decrease in melanocyte function rather than actual loss of melanocytes as the cause of hypopigmentation.
authors.affiliation: Duke University Medical Center, Division of Dermatology, USA. venka004@mc.duke.edu
authors.forename: Priya
authors.initials: P
authors.lastname: Venkatesan
authors.forename: William L
authors.initials: WL
authors.lastname: Fangman
mesh_terms: D000328:Adult; D001284:Atrophy; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D017496:Hypopigmentation / Q000139:chemically induced*; D007270:Injections, Intra-Articular; D012867:Skin / Q000473:pathology*; D013717:Tenosynovitis / Q000188:drug therapy*; D014221:Triamcinolone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D014221:Triamcinolone