Reactivation of medial temporal lobe and human V5/MT+ during the retrieval of motion information: a PET study.
Recent neuroimaging evidence suggests that the retrieval of a prior episode reactivates sensory-processing brain regions that were active when the episode was encoded. However, with regard to reactivation of the medial temporal lobe (MTL), the results remain controversial. In the present study, we used positron emission tomography (PET) to identify the brain regions associated with the encoding and retrieval of motion information. Specifically, we assessed whether overlapping activity was found in both the MTL structures and motion-related cortical regions during the encoding and retrieval of motion information attached to meaningless shapes. During the study, subjects were asked to encode moving (rotating to the right or left) and static meaningless shapes. At subsequent testing, subjects were presented with only static shapes, which had been presented with or without motion during encoding, and were engaged in retrieval tasks of shapes and motion. Overlapping activity was found in the right middle temporal gyrus (V5/MT+) and the left MTL (hippocampus) during the encoding and retrieval of shapes with motion compared with those without motion. These results support the view that the retrieval of specific event information is associated with reactivation of both the MTL and the regions involved during the encoding of that information.
Ueno
Aya
A
Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan. a-ueno@mail.tains.tohoku.ac.jp
Abe
Nobuhito
N
Suzuki
Maki
M
Shigemune
Yayoi
Y
Hirayama
Kazumi
K
Mori
Etsuro
E
Tashiro
Manabu
M
Itoh
Masatoshi
M
Fujii
Toshikatsu
T
D000293:Adolescent; D001931:Brain Mapping / Q000379:methods; D003463:Cues; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D009039:Motion Perception / Q000502:physiology*; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D049268:Positron-Emission Tomography; D021641:Recognition, Psychology / Q000502:physiology*; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism; D014793:Visual Cortex / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism*; D055815:Young Adult