Genetics in osteoarthritis.
Osteoarthritis is a degenerative articular disease with complex pathogeny because diverse factors interact causing a process of deterioration of the cartilage. Despite the multifactorial nature of this pathology, from the 50's it s known that certain forms of osteoarthritis are related to a strong genetic component. The genetic bases of this disease do not follow the typical patterns of mendelian inheritance and probably they are related to alterations in multiple genes. The identification of a high number of candidate genes to confer susceptibility to the development of the osteoarthritis shows the complex nature of this disease. At the moment, the genetic mechanisms of this disease are not known, however, which seems clear is that expression levels of several genes are altered, and that the inheritance will become a substantial factor in future considerations of diagnosis and treatment of the osteoarthritis.
Fernández-Moreno
Mercedes
M
Osteoarticular and Aging Research Lab, Genomics Unit. Biomedical Research Center, INIBIC-CH Universitario A Coruña, A Coruña, Spain.
Rego
Ignacio
I
Carreira-Garcia
Vanessa
V
Blanco
Francisco J
FJ