title: Understanding biophysicochemical interactions at the nano-bio interface.
abstract: Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.
authors.affiliation: Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA. anel@mednet.ucla.edu
authors.forename: Andre E
authors.initials: AE
authors.lastname: Nel
authors.forename: Lutz
authors.initials: L
authors.lastname: Mädler
authors.forename: Darrell
authors.initials: D
authors.lastname: Velegol
authors.forename: Tian
authors.initials: T
authors.lastname: Xia
authors.forename: Eric M V
authors.initials: EM
authors.lastname: Hoek
authors.forename: Ponisseril
authors.initials: P
authors.lastname: Somasundaran
authors.forename: Fred
authors.initials: F
authors.lastname: Klaessig
authors.forename: Vince
authors.initials: V
authors.lastname: Castranova
authors.forename: Mike
authors.initials: M
authors.lastname: Thompson
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods / Q000639:trends; D010316:Particle Size; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D011506:Proteins