Contact-active microbicidal gold surfaces using immobilization of quaternary ammonium thiol derivatives.
Contact-active auto-bactericidal surfaces were obtained by grafting of specially designed thiol derivatives containing antimicrobial quaternary ammonium moieties on gold substrates. The formation and quality of the self-assembled monolayers (SAMs) were characterized by X-ray photoelectron spectroscopy, cyclic voltammetry and contact angle measurements. The bactericidal activity of the modified gold surface was evaluated against Staphylococcus aureus using an original procedure. This activity was demonstrated to be dependent on the length of the alkyl chain borne by the charged nitrogen atom of the quaternary ammonium moiety, and on the contact time.
Thebault
Pascal
P
Université de Nice-Sophia Antipolis, Laboratoire de Chimie des Matériaux Organiques et Métalliques, Institut de Chimie de Nice, Equipe Chimie Organique aux Interfaces, Parc Valrose, 06108 Nice Cedex 2, France. Pascal.Thebault@unice.fr
Taffin de Givenchy
Elisabeth
E
Levy
Richard
R
Vandenberghe
Yves
Y
Guittard
Frédéric
F
Géribaldi
Serge
S
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D055664:Electrochemical Techniques; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties
D000890:Anti-Infective Agents; D000644:Quaternary Ammonium Compounds; D013438:Sulfhydryl Compounds; D006046:Gold