title: Long-term regulation of carotid body function: acclimatization and adaptation--invited article.
abstract: Physiological responses to hypoxia either continuous (CH) or intermittent (IH) depend on the O(2)-sensing ability of the peripheral arterial chemoreceptors, especially the carotid bodies, and the ensuing reflexes play important roles in maintaining homeostasis. The purpose of this article is to summarize the effects of CH and IH on carotid body function and the underlying mechanisms. CH increases baseline carotid body activity and sensitizes the response to acute hypoxia. These effects are associated with hyperplasia of glomus cells and neovascularization. Enhanced hypoxic sensitivity is due to alterations in ion current densities as well as changes in neurotransmitter dynamics and recruitment of additional neuromodulators (endothelin-1, ET-1) in glomus cells. Morphological alterations are in part due to up-regulation of growth factors (e.g. VEGF). Hypoxia-inducible factor-1 (HIF-1), a transcriptional activator might underlie the remodeling of carotid body structure and function by CH. Chronic IH, on the other hand, is associated with recurrent apneas in adults and premature infants. Two major effects of chronic IH on the adult carotid body are sensitization of the hypoxic sensory response and long-lasting increase in baseline activity i.e., sensory long-term facilitation (LTF) which involve reactive oxygen species (ROS) and HIF-1. In neonates, chronic IH leads to sensitization of the hypoxic response but does not induce sensory LTF. Chronic IH-induced sensitization of the carotid body response to hypoxia increases the likelihood of unstable breathing perpetuating in more number of apneas, whereas sensory LTF may contribute to increased sympathetic tone and systemic hypertension associated with recurrent apneas.
authors.affiliation: Department of Medicine, Center for System Biology of O2 Sensing, Chicago, IL 60637, USA. nprabhak@medicine.bsd.uchicago.edu
authors.forename: N R
authors.initials: NR
authors.lastname: Prabhakar
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Peng
authors.forename: G K
authors.initials: GK
authors.lastname: Kumar
authors.forename: J
authors.initials: J
authors.lastname: Nanduri
authors.forename: C
authors.initials: C
authors.lastname: Di Giulio
authors.forename: Sukhamay
authors.initials: S
authors.lastname: Lahiri
mesh_terms: D000064:Acclimatization; D000222:Adaptation, Physiological; D000818:Animals; D002344:Carotid Body / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D013997:Time Factors