Mechanisms of protein aggregation.
Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.
Philo
John S
JS
Alliance Protein Laboratories, Thousand Oaks, CA, USA. jphilo@ap-lab.com
Arakawa
Tsutomu
T
D001702:Biopharmaceutics / Q000379:methods*; D005591:Chemical Fractionation / Q000379:methods*; D008956:Models, Chemical; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000302:isolation & purification*; D011506:Proteins / Q000737:chemistry* / Q000302:isolation & purification*; D013678:Technology, Pharmaceutical / Q000379:methods*
D046912:Multiprotein Complexes; D011506:Proteins