Micromanipulating cancer: microRNA-based therapeutics?
Because microRNAs regulate cancer cell differentiation, proliferation, survival and metastasis, manipulating microRNA function, either by mimicking or inhibiting miRNAs implicated in cancer, could provide a powerful therapeutic strategy to interfere with key pathways for cancer progression. This review will explore some of the opportunities and obstacles to harnessing microRNA biology for cancer therapy.
Petrocca
Fabio
F
Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Lieberman
Judy
J
D000818:Animals; D016503:Drug Delivery Systems; D015972:Gene Expression Regulation, Neoplastic; D015316:Genetic Therapy; D006801:Humans; D035683:MicroRNAs / Q000008:administration & dosage / Q000235:genetics / Q000627:therapeutic use*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*
D035683:MicroRNAs