[Influence of electroacupuncture of "Shuigou" (GV 26) on hippocampal CGRP and NPY contents in cerebral ischemia rats].
OBJECTIVE
To observe the effect of electroacupuncture (EA) on the contents of hippocampal calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY) in cerebral ischemia (CI) rats.


METHODS
Forty SD rats were randomly divided into normal control, sham operation (sham), model and EA groups with 10 cases in each. CI model was duplicated by middle cerebral artery occlusion. EA (2 Hz, 1 mA, continuous waves) was applied to "Shuigou" (GV 26) for 30 min, once daily for 5 days. Hippocampal tissue was taken for assaying the contents of CGRP and NPY with radioimmunoassay.


RESULTS
Compared with sham group and normal control group, hippocampal CGRP content in model group decreased apparently (P<0.01), while NPY content of model group increased significantly (P<0.01). Compared with model group, hippocampal CGRP in EA group increased considerably (P<0.01) and NPY content decreased obviously (P<0.01).


CONCLUSIONS
Electroacupuncture of GV26 can effectively adjust hippocampal CGRP and NPY contents in CI rats, which may contribute to its effect in improving cerebral ischemia.
Huang
Wei
W
School of Acu-moxibustion, Hubei College of Traditional Chinese Medicine, Wuhan 430061, China. weihuang@hbtcm.edu.cn
Wu
Xu-ping
XP
Ding
Yun
Y
Wang
Ya-wen
YW
Wang
Shu-ju
SJ
Sun
Guo-jie
GJ
D015669:Acupuncture Points; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000628:therapy*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D004195:Disease Models, Animal; D015671:Electroacupuncture; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats
D009478:Neuropeptide Y; D015740:Calcitonin Gene-Related Peptide