Abnormal brain lateralization and connectivity in schizophrenia.
Schizophrenia is a complex disorder mainly characterized by thought disturbances, hallucinations, and decay of social and cognitive performances. From past attempts to identify the exclusive brain lesions responsible for specific domains of schizophrenia symptoms such as delusion and auditory hallucinations, recent data pointed towards network alterations leading to abnormal brain asymmetry and connectivity as important determinants of schizophrenia pathophysiology. Several contributions have reported reduced brain lateralization in schizophrenia, causing a failure of left hemisphere dominance. Evidence of altered connectivity among distinct cortical areas is also accumulating. The aim of the present article is to critically review such contributions.
Ribolsi
Michele
M
Clinica Psichiatrica, Dipartimento di Neuroscienze, Università Tor Vergata, Rome, Italy.
Koch
Giacomo
G
Magni
Valentina
V
Di Lorenzo
Giorgio
G
Rubino
Ivo Alex
IA
Siracusano
Alberto
A
Centonze
Diego
D
D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D003952:Diagnostic Imaging / Q000379:methods; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology; D011237:Predictive Value of Tests; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*