title: [Genes that make the endothelial identity].
abstract: The endothelium is a tissue with a distinct identity due to the specific expression of molecular markers by endothelial cells. Further, the endothelium displays a structural heterogeneity illustrated by the expression of specific markers in arteries and in veins. Here, we present a review of the transcriptional and epigenetic mechanisms regulating the expression of the main markers of endothelial cells in man and mouse, demonstrating that there is no common and unique mechanism of specific expression of genes in these cells.
authors.affiliation: Institut de Biologie de Lille, CNRS UMR8161, Equipe Labellisée Ligue Nationale contre le Cancer 2008, Université de Lille I, Université de Lille II, Institut Pasteur de Lille, 1, rue Calmette, 59021 Lille Cedex, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Le Bras
authors.forename: Fabrice
authors.initials: F
authors.lastname: Soncin
mesh_terms: D000818:Animals; D001158:Arteries / Q000166:cytology / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism*; D004742:Enhancer Elements, Genetic; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D018919:Neovascularization, Physiologic / Q000235:genetics*; D009928:Organ Specificity; D011401:Promoter Regions, Genetic; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D014158:Transcription, Genetic; D014680:Veins / Q000166:cytology / Q000378:metabolism
chemical_list: D020794:Receptor Protein-Tyrosine Kinases