[Structure and function of matrix metalloproteinases].
The ECM remodeling is a finely orchestrated process that involves changes in expression of the ECM genes and the activity of proteinases to clear the previous ECM deposit. Among enzymes involved in ECM remodeling, zinc-dependent proteinases--matrix metalloproteinases (MMPs) are believed to be the ones of major importance. MMPs degrade the ECM components and regulate the bioavailability and/or activity of growth factors by cleavage of both matrix and non-matrix substrates or by mediating receptor turnover. This review introduces the members of the MMP family and discusses their domain structure and function, proenzyme activation and the mechanism of inhibition.
Olszyński
Krzysztof
K
Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN, Pracownia Fizjologii Nerek i Płynów Ustrojowych, Warszawa.
Zimowska
Małgorzata
M
D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D020782:Matrix Metalloproteinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology; D018919:Neovascularization, Physiologic / Q000502:physiology
D020782:Matrix Metalloproteinases