[Significance of CSF levels of tau protein and beta42-amyloid for diagnosis and differential diagnosis of dementia diseases in a specialized geriatric hospital].
Considering the incidence of dementia, the development of procedures that allow correct differential diagnosis is gaining increasing importance. The analysis of spinal fluid from 632 patients, who were admitted with suspected dementia, diagnosed dementia or dementia of unclear etiology, showed that there was high differential diagnostic power for tau protein, but not for beta-amyloid.
Nehen
H G
HG
Contilia GmbH, Geriatrie-Zentrum Haus Berge, Germaniastrasse 3, Essen, Germany.
Honneth
J
J
Haseke
J
J
Fahnenstich
H
H
D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D015577:Geriatric Assessment / Q000379:methods / Q000706:statistics & numerical data; D005858:Germany / Q000453:epidemiology; D006299:Health Services for the Aged / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008297:Male; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D016229:Amyloid beta-Peptides; D015415:Biomarkers; C054369:MAPT protein, human; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins