Gene regulatory networks in embryonic stem cells and brain development.
Embryonic stem cells (ESCs) are endowed with the ability to generate multiple cell lineages and carry great therapeutic potentials in regenerative medicine. Future application of ESCs in human health and diseases will embark on the delineation of molecular mechanisms that define the biology of ESCs. Here, we discuss how the finite ESC components mediate the intriguing task of brain development and exhibit biomedical potentials to cure diverse neurological disorders.
Ghosh
Dhimankrishna
D
Institute for Systems Biology, Seattle, Washington 98103, USA.
Yan
Xiaowei
X
Tian
Qiang
Q
D000818:Animals; D001921:Brain / Q000196:embryology*; D001932:Brain Neoplasms / Q000235:genetics; D002454:Cell Differentiation / Q000502:physiology; D047108:Embryonic Development / Q000235:genetics*; D053595:Embryonic Stem Cells / Q000502:physiology* / Q000637:transplantation; D053263:Gene Regulatory Networks; D005910:Glioma / Q000235:genetics; D006801:Humans; D051379:Mice; D054261:Neurulation / Q000235:genetics*; D039904:Pluripotent Stem Cells / Q000502:physiology* / Q000637:transplantation; D051381:Rats; D033581:Stem Cell Transplantation