Warfarin-induced intracerebral hemorrhage associated with microbleeds.
BACKGROUND
Microbleeds (MBs), proposed as a biomarker for microangiopathy, have been suggested as a predictor of spontaneous or thrombolysis-related intracerebral hemorrhage (ICH) in acute ischemic stroke. However, the relationship between MBs and warfarin-induced ICH is not clear.


METHODS
We describe two patients who developed warfarin-induced ICH at the site of MBs documented in previous MRI.


CONCLUSIONS
The presence of MBs might increase the risk of ICH after warfarin use in ischemic stroke patients. A large cohort study is required to confirm the relationship of MBs with warfarin-induced ICH.
Lee
Gha-Hyun
GH
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Kwon
Sun U
SU
Kang
Dong-Wha
DW