title: A randomized clinical trial of autologous platelet-rich plasma in the treatment of mandibular degree II furcation defects.
abstract: OBJECTIVE
  A combined technique using a platelet-rich plasma (PRP)/bovine porous bone mineral/guided tissue regeneration membrane was found to be an effective modality for the treatment of mandibular grade II furcation defects. To elucidate the role played by each component, the present randomized, double-blind study is designed to evaluate the effectiveness of autologous PRP alone in the treatment of mandibular degree II furcation defects compared with open flap debridement (OFD).
  
  
  METHODS
  Using a split-mouth design, 40 mandibular degree II furcation defects were treated either with autologous PRP or OFD. Plaque index, sulcus bleeding index, vertical probing depth, relative vertical and horizontal clinical attachment level and gingival marginal level were recorded at baseline and 6 months post-operatively. Vertical and horizontal defect depths were also recorded using spiral computed tomography.
  
  
  RESULTS
  A statistically significant difference was observed in all the clinical and radiographic parameters at the sites treated with PRP as compared with those with OFD. However, all the furcation defects retained their degree II status.
  
  
  CONCLUSIONS
  Despite a significant improvement, lack of complete closure of furcation defects implies a limited role of autologous PRP as a regenerative material in the treatment of furcation defects, necessitating further long-term studies.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Karnataka, India. periodontics_gdc@yahoo.co.in
authors.forename: Avani Rangaraju
authors.initials: AR
authors.lastname: Pradeep
authors.forename: Sujatha
authors.initials: S
authors.lastname: Pai
authors.forename: Garima
authors.initials: G
authors.lastname: Garg
authors.forename: Prapulla
authors.initials: P
authors.lastname: Devi
authors.forename: Sharath Kumara
authors.initials: SK
authors.lastname: Shetty
mesh_terms: D000328:Adult; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000627:therapeutic use*; D003646:Debridement; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000601:surgery / Q000628:therapy*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000601:surgery / Q000628:therapy; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D053657:Platelet-Rich Plasma; D016896:Treatment Outcome
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals