title: [Oxidative stress of spermatozoa in pathogenesis of male infertility].
abstract: Oxidative stress is a common pathology seen in approximately half of all infertile men. Peroxides causing infertility are generated by sperm and seminal leukocytes. Oxidative stress occurs when production of potentially destructive reactive oxygen species exceeds natural antioxidant defenses resulting in cellular damage. The causes of the oxidative stress include environmental factors (phthalates et al.), chronic inflammation of the prostate, varicocele, autoimmune response to seminal antigens.
authors.forename: V A
authors.initials: VA
authors.lastname: Bozhedomov
authors.forename: D S
authors.initials: DS
authors.lastname: Gromenko
authors.forename: I V
authors.initials: IV
authors.lastname: Ushakova
authors.forename: M V
authors.initials: MV
authors.lastname: Toroptseva
authors.forename: Sh N
authors.initials: ShN
authors.lastname: Galimov
authors.forename: L A
authors.initials: LA
authors.lastname: Alekcandrova
authors.forename: O V
authors.initials: OV
authors.lastname: Teodorovich
authors.forename: T G
authors.initials: TG
authors.lastname: Sukhikh
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002908:Chronic Disease; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013094:Spermatozoa / Q000378:metabolism* / Q000473:pathology
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species