Nicotinic acetylcholine receptors and the ascending dopamine pathways.
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in midbrain dopamine neurons that project to dorsal striatum, nucleus accumbens and prefrontal cortex. Thus nAChRs can influence the functions of these three pathways, notably motor control, 'reward' and executive function, respectively. Diverse subtypes of nAChRs have been identified on dopamine cell bodies and terminals as well as on neighbouring afferents and interneurons. Here we review the molecular and cellular mechanisms through which nAChRs exert their influence on these pathways in rodents.
Livingstone
Phil D
PD
Department of Biology & Biochemistry, University of Bath, Bath BA2 7AY, UK.
Wonnacott
Susan
S
D000109:Acetylcholine / Q000502:physiology; D000200:Action Potentials; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D008636:Mesencephalon / Q000166:cytology / Q000502:physiology; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009538:Nicotine / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism; D021122:Protein Subunits / Q000096:biosynthesis; D011978:Receptors, Nicotinic / Q000096:biosynthesis / Q000502:physiology*; D012377:Rodentia
D021122:Protein Subunits; D011978:Receptors, Nicotinic; D009538:Nicotine; D000109:Acetylcholine; D004298:Dopamine