title: Cerebrovascular reactivity and dynamic autoregulation in ischaemic subcortical white matter disease.
abstract: BACKGROUND
  It has been suggested that impaired cerebral autoregulation and vasodilatory capacity may play in role in the pathogenesis of the leukoaraiosis seen in small vessel disease. Adequate perfusion of the deep white matter of the brain depends on the relationships between blood pressure (BP), cerebral vasoreactivity and autoregulation.
  
  
  METHODS
  24 h ambulatory BP measurement, quantitative volumetric MRI analysis of white matter lesion (WML) volume and transcranial Doppler ultrasound assessments of CO(2) reactivity in response to hypercapnia and dynamic cerebral autoregulatory index (ARI) were undertaken in 64 patients with cerebral small vessel disease.
  
  
  RESULTS
  Subjects had mean 24 h BP 133/76 mm Hg (SD 13/9), median WML volume 7169 (IQR 20497) mm(3), mean CO(2) reactivity 83.6 (SD 37.4)% and mean ARI 5.6 (SD 1.4) (range 0-9). In multivariate models, after adjusting for age, gender, vascular risk profile and WML volume, ARI correlated with 24 h mean BP levels (R(2) = 0.127, t = 2.440, p = 0.019) and CO(2) reactivity correlated with duration of hypertension (R(2) = 0.085, t = -2.244, p = 0.029). In individuals with hypertension for more than 10 years, ARI also correlated with nocturnal BP dipping (r = 0.806, p = 0.002). ARI and CO(2) reactivity were unaffected by WML volumes, and ARI and CO(2) reactivity were unrelated.
  
  
  CONCLUSIONS
  Cerebral autoregulation and CO(2) reactivity are two distinct processes which are not related to WML volume but are related to BP levels and duration of hypertension, respectively. Greater nocturnal dipping was associated with higher ARI values, suggesting preservation of autoregulation in patients with increased vulnerability to reduced cerebral perfusion.
authors.affiliation: Department of Stroke Medicine, Academic Neurosciences Centre, PO41, Institute of Psychiatry, King's College London, London, UK. jonathan.birns@gstt.nhs.uk
authors.forename: J
authors.initials: J
authors.lastname: Birns
authors.forename: J
authors.initials: J
authors.lastname: Jarosz
authors.forename: H S
authors.initials: HS
authors.lastname: Markus
authors.forename: L
authors.initials: L
authors.lastname: Kalra
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002245:Carbon Dioxide / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D049292:Leukoaraiosis / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D017585:Ultrasonography, Doppler, Transcranial; D014664:Vasodilation / Q000502:physiology*
chemical_list: D002245:Carbon Dioxide