Highly enantioselective synthesis of sultams via Pd-catalyzed hydrogenation.
Using pd(cf(3)co(2))2/(S,S)-f-Binaphane as the catalyst, an efficient enantioselective synthesis of sultams was developed via asymmetric hydrogenation of the corresponding cyclic imines with high enantioselectivities. The hydrogenation products can be conveniently transformed to chiral homoallylic amines without loss of enantioselectivity.
Yu
Chang-Bin
CB
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
Wang
Da-Wei
DW
Zhou
Yong-Gui
YG
D002384:Catalysis; D006865:Hydrogenation; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
D007097:Imines; D009942:Organometallic Compounds; D013449:Sulfonamides; D010165:Palladium