ASMase: the tailor of cytotoxic T cell granule exocytosis.
Deficiency in acid sphingomyelinase causes lysosomal storage of sphingomyelin, mediates resistance to stress-induced apoptosis and alters susceptibility to certain infections. New work links acid sphingomyelinase to the granule exocytosis of cytotoxic T cells.
Bogdan
Christian
C
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D005089:Exocytosis / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D055571:Secretory Pathway / Q000276:immunology; D022142:Secretory Vesicles / Q000378:metabolism*; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism*; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
C112980:acid sphingomyelinase-1; D013108:Sphingomyelin Phosphodiesterase