[Immunobiological properties of recombinant L peptide from the Pseudomonas aeruginosa outer membrane].
The gene encoding plasma membrane protein L (OprL) was cloned and expressed in E. coli. It was shown that the recombinant protein had immunogenic properties and protected laboratory animals from experimental P. aeruginosa infection. Rabbit hyperimmune sera raised against recombinant L protein possessed antimicrobial activity and prevented infection with P. aeruginosa.
Gatypova
E V
EV
Zlygostev
S A
SA
Kaloshin
A A
AA
Mikhaĭlova
N A
NA
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D007106:Immune Sera; D008074:Lipoproteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D051379:Mice; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D011817:Rabbits; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology
D001425:Bacterial Outer Membrane Proteins; D007106:Immune Sera; D008074:Lipoproteins; D011994:Recombinant Proteins