Thyroid modulation of TNF-dependent apoptosis and formation of chronic liver disease in endogenous intoxication in rats.
Dynamic studies on rats with chronic endogenous intoxication showed involvement of the thyroid hormones in modulation of liver injury. Thyroid modulation is realized as more intense induction of TNF apoptosis in the cells and stimulation of microcirculatory disorders at the expense of nitroxide synthase expression. The modulation is quantitative, augmenting liver damage.
Kalashnikova
S A
SA
AV Vishnevsky Institute of Surgery, the Russian Academy of Medical Sciences, Volgograd State Medical University, Moscow, Russian.
Goryachev
A N
AN
Novochadov
V V
VV
Shchyogolev
A I
AI
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity; D053148:Caspase 3 / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008070:Lipopolysaccharides / Q000009:adverse effects / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism* / Q000473:pathology; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D051381:Rats; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013963:Thyroid Hormones / Q000097:blood; D013974:Thyroxine / Q000008:administration & dosage / Q000633:toxicity; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D008070:Lipopolysaccharides; D053221:TNF-Related Apoptosis-Inducing Ligand; D013963:Thyroid Hormones; C505655:Tnfsf10 protein, rat; D014409:Tumor Necrosis Factor-alpha; D002251:Carbon Tetrachloride; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D053148:Caspase 3; D013974:Thyroxine