Chiral separations by CE employing CDs.
This paper summarizes the history of chiral separations done by using electromigration methods with CDs. Several enantioresolution mechanisms and a wide number of chiral selectors have been applied to the separation of optical isomers by CE. Among them inclusion-complexation with CDs or their derivatives played a very important role in CE. Since the beginning our group was involved in studying method optimization for enantiomer resolution by using these chiral selectors. One of our publications was the basis for further development in the field, at least for us. New chiral selectors, development of theory, new methodological approaches and a wide number of practical applications are the main results achieved in the last almost 25 years using CE as an enantioseparative technique.
Fanali
Salvatore
S
Institute of Chemical Methodologies, National Council of Research, Area della Ricerca di Roma I, Monterotondo Scalo (Rome), Italy. salvatore.fanali@imc.cnr.it
D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000266:history / Q000379:methods*; D049673:History, 20th Century; D049674:History, 21st Century; D013237:Stereoisomerism
D003505:Cyclodextrins