Dynamic properties of molecular motors in the divided-pathway model.
The mechanisms of molecular motors transport are important for understanding multiple biological processes. Recent single-molecule experiments indicate that motor proteins myosin V moves along protein filaments via a complex biochemical pathway that consists of sequentially coupled linear and parallel two-chain segments. We investigate analytically the corresponding discrete-state stochastic divided-pathway model for molecular motors transport. Explicit expressions are obtained for velocities and dispersions. The dynamic properties of motor proteins in the divided-pathway model are compared with those in single-chain linear and parallel-pathway stochastic models. It is argued that modifying biochemical pathways has a strong effect on the dynamic properties, and it allows motor proteins to be more flexible in performing their biological functions.
Das
Rahul Kumar
RK
Department of Chemistry, Rice University, Houston, TX 77005, USA.
Kolomeisky
Anatoly B
AB
D007700:Kinetics; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism*; D024701:Myosin Type V / Q000378:metabolism
D020409:Molecular Motor Proteins; D024701:Myosin Type V