Effect of a prolyl endopeptidase inhibitor benzyloxycarbonyl-alanyl-proline on the development of experimental depressive syndrome in rats.
The effects of a competitive prolyl endopeptidase inhibitor benzyloxycarbonyl-alanyl-proline were studied in rats with experimental dopamine deficiency-dependent depressive syndrome due to systemic administration of a proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine for 14 days. The inhibitor was injected intraperitoneally 30 min before treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2nd week of the study). This substance contributed to rapid disappearance of depressive symptoms during the recovery of behavioral activity. Our results indicate that benzyloxycarbonyl-alanyl-proline has the antidepressant properties.
Khlebnikova
N N
NN
Laboratory for General Pathophysiology of Nervous System, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Laboratory of Psychopharmacology, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. nanikh@yandex.ru
Krupina
N A
NA
Orlova
I N
IN
Bogdanova
N G
NG
Zolotov
N N
NN
Kryzhanovskii
G N
GN
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003866:Depressive Disorder / Q000139:chemically induced*; D004298:Dopamine / Q000172:deficiency; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D000085822:Prolyl Oligopeptidases; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000378:metabolism*
D004791:Enzyme Inhibitors; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases; D004298:Dopamine