Efficient asymmetric total syntheses of cryptocarya triacetate, cryptocaryolone, and cryptocaryolone diacetate.
Concise and efficient asymmetric total syntheses of three substituted alpha-pyrone-type natural products have been accomplished via 7-9 steps from 5b in high overall yields, which involve linchpin coupling, ring-closing metathesis, and a tandem sequence of deacetylation and intramolecular oxa-Michael addition as the key steps.
Wang
Xiaolei
X
State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
Wang
Wenkuan
W
Zheng
Huaiji
H
Su
Yingpeng
Y
Jiang
Tuo
T
He
Yongping
Y
She
Xuegong
X
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry
D001688:Biological Products; D011753:Pyrones; C476917:cryptocarya triacetate; C476918:cryptocaryolone; C542715:cryptocaryolone diacetate