Effects of succinic and glutamic acid combination on energy metabolism in the liver of mice under conditions of hypoxia.
Treatment of mice by a combination of succinic and glutamic acids prevented the metabolic disorders in the liver under conditions of normobaric hypoxia. In addition, the activity of the mitochondrial fast metabolic cluster remained intact and lipid peroxidation was limited.
Vasilyev
K Yu
KY
Laboratory of Molecular Pharmacology with Pharmacokinetics Group, Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
Kiselyova
A A
AA
Khazanov
V A
VA
D000818:Animals; D004338:Drug Combinations; D004734:Energy Metabolism / Q000187:drug effects*; D018698:Glutamic Acid / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D019802:Succinic Acid / Q000494:pharmacology*
D004338:Drug Combinations; D018698:Glutamic Acid; D019802:Succinic Acid