Synthesis and analysis of potential DNA intercalators containing quinoline-glucose hybrids.
A new series of potential DNA bisintercalators have been designed by linking 8-hydroxy-quinoline to the 6-CH(2)OH group of glucose and connecting the 1-OH group of glucose with various linkers, such as quinol, glycol, and triethylene glycol. These new compounds were well-synthesized and fully characterized. Preliminary binding assays of these compounds to calf thymus DNA (CT-DNA) were conducted using UV-absorption and fluorescence spectroscopy analysis. The primary antitumor activity of these compounds was also performed.
Li
Wei
W
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Pharmacy, Ocean University of China, Qingdao 266003, China.
Zhang
Zhong-Wei
ZW
Wang
Shi-Xi
SX
Ren
Su-Mei
SM
Jiang
Tao
T
D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry*; D005947:Glucose / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011804:Quinolines / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
D007364:Intercalating Agents; D011804:Quinolines; D004247:DNA; D005947:Glucose