Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4+T cells.
CD26 binds to caveolin-1 in antigen-presenting cells (APC), and that ligation of CD26 by caveolin-1 induces T cell proliferation in a TCR/CD3-dependent manner. We report herein the effects of CD26-caveolin-1 costimulatory blockade by fusion protein caveolin-1-Ig (Cav-Ig). Soluble Cav-Ig inhibits T cell proliferation and cytokine production in response to recall antigen, or allogeneic APC. Our data hence suggest that blocking of CD26-associated signaling by soluble Cav-Ig may be an effective approach as immunosuppressive therapy.
Ohnuma
Kei
K
Department of Rheumatology and Allergy, Research Hospital, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Tokyo 108-8639, Japan.
Uchiyama
Masahiko
M
Hatano
Ryo
R
Takasawa
Wataru
W
Endo
Yuko
Y
Dang
Nam H
NH
Morimoto
Chikao
C
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D051242:Caveolin 1 / Q000276:immunology*; D002478:Cells, Cultured; D017635:Clonal Anergy; D018819:Dipeptidyl Peptidase 4 / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D011993:Recombinant Fusion Proteins / Q000276:immunology*
D051242:Caveolin 1; D007074:Immunoglobulin G; D011993:Recombinant Fusion Proteins; D018819:Dipeptidyl Peptidase 4