Pharmacokinetics and ex vivo pharmacodynamic antimalarial activity of dihydroartemisinin-piperaquine in patients with uncomplicated falciparum malaria in Vietnam.
Compared to healthy subjects, malaria patients show a reduction in the mean oral clearance (1.19 versus 5.87 liters/h/kg of body weight) and apparent volume of distribution (1.47 versus 8.02 liters/kg) of dihydroartemisinin in Vietnamese patients following treatment with dihydroartemisinin-piperaquine (Artekin) for uncomplicated Plasmodium falciparum. Dihydroartemisinin is responsible for most of the ex vivo antimalarial activity of dihydroartemisinin-piperaquine.
Nguyen
Dao Van Hoang
DV
Department of Infectious Diseases, Military Hospital 175, Ho Chi Minh City, Vietnam.
Nguyen
Quoc Phuc
QP
Nguyen
Ngoa Dang
ND
Le
Thuy Thi Thanh
TT
Nguyen
The Duy
TD
Dinh
Duy Ngoc
DN
Nguyen
Thanh Xuan
TX
Bui
Dai
D
Chavchich
Marina
M
Edstein
Michael D
MD
D000293:Adolescent; D000962:Antimalarials / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D037621:Artemisinins / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011804:Quinolines / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D014744:Vietnam; D055815:Young Adult; D010879:Piperazines
D000962:Antimalarials; D037621:Artemisinins; D011804:Quinolines; C039060:artenimol; C034759:piperaquine; D010879:Piperazines