title: Spontaneous brain activity in the newborn brain during natural sleep--an fMRI study in infants born at full term.
abstract: Recent progress in functional neuroimaging research has provided the opportunity to probe at the brain's intrinsic functional architecture. Synchronized spontaneous neuronal activity is present in the form of resting-state networks in the brain even in the absence of external stimuli. The objective of this study was to investigate the presence of resting-state networks in the unsedated infant brain born at full term. Using functional MRI, we investigated spontaneous low-frequency signal fluctuations in 19 healthy full-term infants. Resting-state functional MRI data acquired during natural sleep was analyzed using independent component analysis. We found five resting-state networks in the unsedated infant brain born at full term, encompassing sensory cortices, parietal and temporal areas, and the prefrontal cortex. In addition, we found evidence for a resting-state network that enclosed the bilateral basal ganglia.
authors.affiliation: Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden. Peter.Fransson@ki.se
authors.forename: Peter
authors.initials: P
authors.lastname: Fransson
authors.forename: Beatrice
authors.initials: B
authors.lastname: Skiöld
authors.forename: Mathias
authors.initials: M
authors.lastname: Engström
authors.forename: Boubou
authors.initials: B
authors.lastname: Hallberg
authors.forename: Mikael
authors.initials: M
authors.lastname: Mosskin
authors.forename: Ulrika
authors.initials: U
authors.lastname: Aden
authors.forename: Hugo
authors.initials: H
authors.lastname: Lagercrantz
authors.forename: Mats
authors.initials: M
authors.lastname: Blennow
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009415:Nerve Net / Q000502:physiology*; D012890:Sleep / Q000502:physiology*