title: [Value of 3D 1H-MRS with body coil at 3T in the differential diagnosis of the prostate cancer].
abstract: OBJECTIVE
  To assess the value of three dimensional proton magnetic resonance spectroscopy (3D 1H-MRS) with body coil at 3T in the differential diagnosis of prostate cancer.
  
  
  METHODS
  Forty patients suspected of prostate cancer underwent MRI and MRS examinations, and then transrectal ultrasound guided prostate biopsy for pathological diagnosis. The MRI and MRS features of benign prostate hyperplasia, prostate cancer and prostatic intraepithelial neoplasia (PIN) were analyzed in comparison with the pathological reports, and the receiver operating characteristic curve was drawn for the diagnosis of cancer from peripheral zones.
  
  
  RESULTS
  The examinations were accomplished for all the patients. The mean ratios of (Cho + Cre)/Cit in the interstitial and glandular hyperplasia tissues, the cancer tissue of the central and peripheral glands, the healthy peripheral gland and PIN were 0.75 +/- 0.23, 0.59 +/- 0.14, 1.79 +/- 0.90, 1.18 +/- 0.95, 0.46 +/- 0.18, and 0.97 +/- 0.10, respectively, with statistically significant differences between the cancer and normal prostate tissues (P < 0.01). The optimum threshold for the diagnosis of prostate cancer in the peripheral zone was 0.68 with a sensitivity of 88.6% and a specificity of 88.7%.
  
  
  CONCLUSIONS
  The 3D 1H-MRS with body coil at 3T has a high sensitivity and specificity in the differential diagnosis of prostate cancer, and can provide valuable information for the diagnosis of PIN.
authors.affiliation: Department of Urology, The First Affiliated Hospital of SUN Yat-sen University, Guangzhou, Guangdong 510080, China. wangfeicard@tom.com
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Dai
authors.forename: Xiang-Zhou
authors.initials: XZ
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Ya-Qing
authors.initials: YQ
authors.lastname: Chen
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Mao
authors.forename: Dao-Hu
authors.initials: DH
authors.lastname: Wang
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Deng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D006801:Humans; D021621:Imaging, Three-Dimensional; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity