Modeling of oscillatory bursting activity of pancreatic beta-cells under regulated glucose stimulation.
A mathematical model to describe the oscillatory bursting activity of pancreatic beta-cells is combined with a model of glucose regulation system in this work to study the bursting pattern under regulated extracellular glucose stimulation. The bursting electrical activity in beta-cells is crucial for the release of insulin, which acts to regulate the blood glucose level. Different types of bursting pattern have been observed experimentally in glucose-stimulated islets both in vivo and in vitro, and the variations in these patterns have been linked to changes in glucose level. The combined model in this study enables us to have a deeper understanding on the regime change of bursting pattern when glucose level changes due to hormonal regulation, especially in the postprandial state. This is especially important as the oscillatory components of electrical activity play significant physiological roles in insulin secretion and some components have been found to be lost in type 2 diabetic patients.
Chew
Yin Hoon
YH
Faculty of Science, Engineering and Technology (FSET), Perak Campus, Universiti Tunku Abdul Rahman, Jalan Universiti, Perak, Malaysia.
Shia
Yoke Lin
YL
Lee
Chew Tin
CT
Majid
Fadzilah Adibah Abdul
FA
Chua
Lee Suan
LS
Sarmidi
Mohamad Roji
MR
Aziz
Ramlan Abdul
RA
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D005941:Glucokinase / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000378:metabolism*; D008954:Models, Biological
D001786:Blood Glucose; D005941:Glucokinase; D005947:Glucose