[Acute inflammation phase reactants and interleukin-8 in myocardial infarction].
The study was undertaken to search for additional diagnostic criteria allowing the depth of myocardial damage to be estimated in males aged 57.2 +/- 9.6 years. Few interrelated acute phase reaction indices, including the levels of interleukin-8 (IL-8), lactoferrin (LF), alpha2-macroglobulin (alpha2-MG), plasmin (PL) and alpha2-MG-PL circulating complexes, were studied in serum on days 1, 7, and 17 of the onset of the disease. In small-focal myocardial infarction, the levels of alpha2-MG and PL were decreased on day 1 and those of LF and IL-8 were increased on day 14. On the contrary, in large-focal myocardial infarction, the concentrations of IL-8 and LF rose just on day 1 while those of alpha2-MG and PL remained unchanged. The detected differences may be used as additional criteria in differential diagnosis, particularly when ECG was of no informative value. Further, the concurrent elevation of alpha2-MG, PL, and PL-alpha2MG concentrations in large-focal myocardial infarction is indicative of poor prognosis.
Zorin
N A
NA
Podkhomutnikov
V M
VM
Iankin
M Iu
MIu
Zorina
V N
VN
Arkhipova
S V
SV
Riabicheva
T G
TG
D000209:Acute-Phase Proteins / Q000276:immunology*; D000210:Acute-Phase Reaction / Q000097:blood / Q000276:immunology; D000368:Aged; D004562:Electrocardiography; D006801:Humans; D016209:Interleukin-8 / Q000097:blood / Q000276:immunology*; D007781:Lactoferrin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology*; D000511:alpha-Macroglobulins / Q000378:metabolism
D000209:Acute-Phase Proteins; D016209:Interleukin-8; D000511:alpha-Macroglobulins; D007781:Lactoferrin