Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression.
Dissolved organic matter (DOM) in seawater can be defined as the fraction of organic matter that passes through a filter of sub micron pore size. In this study, we have examined the effect of DOM of deep seawater (DSW) from Pacific Ocean on platelet aggregation and atherosclerosis progression. DSW was passed through a series of filters and then through an Octadecyl C18 filter; the retained substance in ethanol was designated as C18 extractable DOM (C18-DOM). Our studies showed that C18-DOM treatment inhibited platelet aggregation, P-selectin expression and activity of COX-1 significantly. C18-DOM increased the expression of anti-atherogenic molecule namely heme oxygenase-1 in endothelial cells and all these data showed that C18-DOM is exhibiting aspirin-like effects. Moreover our in vivo studies showed that C18-DOM feeding slowed remarkably the progression of atherosclerosis. Our study demonstrated a novel biological effect of oceanic DOM, which has several important implications, including a possible therapeutic strategy for atherosclerosis.
Radhakrishnan
Geethalakshmi
G
Department of Surgery II, Faculty of Medicine, Kochi University, Japan.
Yamamoto
Morio
M
Maeda
Hironori
H
Nakagawa
Aimi
A
KatareGopalrao
Rajesh
R
Okada
Hironobu
H
Nishimori
Hideaki
H
Wariishi
Seiichiro
S
Toda
Eiji
E
Ogawa
Hiroshi
H
Sasaguri
Shiro
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism*; D015374:Biosensing Techniques; D002784:Cholesterol / Q000378:metabolism; D051545:Cyclooxygenase 1 / Q000737:chemistry / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D004800:Enzymes, Immobilized / Q000037:antagonists & inhibitors / Q000737:chemistry; D019007:P-Selectin / Q000037:antagonists & inhibitors; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D012623:Seawater / Q000737:chemistry*; D017539:Tunica Intima / Q000187:drug effects / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004800:Enzymes, Immobilized; D019007:P-Selectin; D002784:Cholesterol; D051545:Cyclooxygenase 1; D001241:Aspirin