[Review of 32 gastro-intestinal stromal tumours with CD117 antigen].
OBJECTIVE
The aim of this study is to review clinical data, histological and immunohistochemical findings and prognosis of stromal gastrointestinal tumors.


METHODS
A retrospective Study of 32 cases of stromal gastrointestinal tumors diagnosed in the Department of Pathology of Mongi Slim Hospital of Tunis from 1991 to 2004.


RESULTS
The average age of the patients was of 54.4 years, equal for sex. Tumors were essentially gastric (50%) and of the small intestine (37.5%). All the patients had surgical treatment. Gastro-intestinal Stromal Tumors or GIST represent the most frequent stromal tumor with 56.2% of cases.


CONCLUSIONS
After immunohistochimestry study, using CD117 antigen, this revision allows better management of GIST. Glivec is the standard treatment of advanced GIST.
Lahmar-Boufaroua
Ahlem
A
Service d'Anatomie Pathologique, Hôpital Mongi Slim, La Marsa, Tunisie.
Ben Slama
Sana
S
Bouraoui
Saadia
S
Gharbi
Lassaad
L
Goutallier
Carole
C
Manai
Saber
S
Gharbi
Walid
W
Mzabi-Regaya
Sabah
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D014408:Biomarkers, Tumor / Q000378:metabolism*; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D007078:Ileal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D000068877:Imatinib Mesylate; D007580:Jejunal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D011743:Pyrimidines / Q000627:therapeutic use; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D001549:Benzamides; D014408:Biomarkers, Tumor; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit