C-reactive protein, genetically elevated levels and risk of ischemic heart and cerebrovascular disease.
We tested whether genetically elevated levels of C-reactive protein (CRP) cause increased risk of ischemic heart disease and ischemic cerebrovascular disease. Levels of CRP >3mg/L, compared with levels <1mg/L, associated with a 1.6- and 1.3-fold increased risk of ischemic heart disease and ischemic cerebrovascular disease. Genotype combinations of the 4 CRP polymorphisms associated with up to a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations did not associate with increased risk of ischemic heart and cerebrovascular disease.
Zacho
Jeppe
J
Department of Clinical Biochemistry, The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Tybjaerg-Hansen
Anne
A
Nordestgaard
Børge Grønne
BG
D002097:C-Reactive Protein / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000097:blood*; D006801:Humans; D017202:Myocardial Ischemia / Q000097:blood*; D012307:Risk Factors
D002097:C-Reactive Protein