The role of fibroblast growth factor 21 (FGF21) on energy balance, glucose and lipid metabolism.
FGF21 is a novel member of the FGFs family, is mainly expressed in liver and it functions as a potent activator of glucose uptake on adipocytes. When over expressed in transgenic mice, it protects animals from diet-induced obesity and its administration to diabetic rodents and monkeys lowers blood glucose and triglyceride levels. Recently, increased levels of FGF21 have been identified as an independent risk factor related with metabolic syndrome. A review of the relevant roles of FGF21 in metabolism is presented here.
Cuevas-Ramos
Daniel
D
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Department of Endocrinology and Metabolism, Mexico City, Mexico.
Almeda-Valdes
Paloma
P
Aguilar-Salinas
Carlos A
CA
Cuevas-Ramos
Gabriel
G
Cuevas-Sosa
Andres A
AA
Gomez-Perez
Francisco J
FJ
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors
C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D005947:Glucose