A facile three-component solid phase synthesis of steroidal A-ring fused pyrimidines under microwave irradiation.
The preparation of ring-A fused pyrimidines at the steroidal 2,3-position is herein described. The novel steroidal pyrimidines were prepared from the solid phase three-component reaction of 2-hydroxymethylene-3-keto steroids, arylaldehydes and ammonium acetate under microwave irradiation.
Barthakur
Madan G
MG
Medicinal Chemistry Division, North-East Institute of Science and Technology, Jorhat 785006, India.
Gogoi
Shyamalee
S
Dutta
Mandakini
M
Boruah
Romesh C
RC
D000085:Acetates / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D007664:Ketosteroids / Q000737:chemistry; D008872:Microwaves; D011743:Pyrimidines / Q000737:chemistry*; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry
D000085:Acetates; D000447:Aldehydes; D007664:Ketosteroids; D011743:Pyrimidines; D013256:Steroids; C030986:pyrimidine; C018824:ammonium acetate