title: A mathematical description of nerve fiber bundle trajectories and their variability in the human retina.
abstract: We developed a mathematical model wherein retinal nerve fiber trajectories can be described and the corresponding inter-subject variability analyzed. The model was based on traced nerve fiber bundle trajectories extracted from 55 fundus photographs of 55 human subjects. The model resembled the typical retinal nerve fiber layer course within 20 degrees eccentricity. Depending on the location of the visual field test point, the standard deviation of the calculated corresponding angular location at the optic nerve head circumference ranged from less than 1 degrees to 18 degrees , with an average of 8.8 degrees .
authors.affiliation: Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. n.m.jansonius@ohk.umcg.nl
authors.forename: N M
authors.initials: NM
authors.lastname: Jansonius
authors.forename: J
authors.initials: J
authors.lastname: Nevalainen
authors.forename: B
authors.initials: B
authors.lastname: Selig
authors.forename: L M
authors.initials: LM
authors.lastname: Zangwill
authors.forename: P A
authors.initials: PA
authors.lastname: Sample
authors.forename: W M
authors.initials: WM
authors.lastname: Budde
authors.forename: J B
authors.initials: JB
authors.lastname: Jonas
authors.forename: W A
authors.initials: WA
authors.lastname: Lagrèze
authors.forename: P J
authors.initials: PJ
authors.lastname: Airaksinen
authors.forename: R
authors.initials: R
authors.lastname: Vonthein
authors.forename: L A
authors.initials: LA
authors.lastname: Levin
authors.forename: J
authors.initials: J
authors.lastname: Paetzold
authors.forename: U
authors.initials: U
authors.lastname: Schiefer
mesh_terms: D005901:Glaucoma / Q000473:pathology*; D006801:Humans; D008959:Models, Neurological; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology; D055351:Retinal Neurons / Q000473:pathology*; D012189:Retrospective Studies; D058609:Visual Field Tests / Q000379:methods; D014794:Visual Fields