title: Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin.
abstract: Photodynamic therapy (PDT) is used to treat malignant and nonmalignant diseases. It is also used for cosmetological skin treatment. PDT is generally considered to have a low risk of carcinogenicity. However, instances of nonmalignant human tumors turning malignant have been linked to PDT. In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA). Of these drugs, ALA and PP(Arg)(2) were found the most efficient. PDT reduced the number of papillomas, but with increasing effectiveness of the drugs, the risk of malignant transformation of the papillomas into squamous cell carcinomas increased. The underlying mechanisms are not clear and further investigations are needed.
authors.affiliation: Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, Gdansk, Poland. kwitniewski@amg.gda.pl
authors.forename: Mateusz
authors.initials: M
authors.lastname: Kwitniewski
authors.forename: Dawid
authors.initials: D
authors.lastname: Jankowski
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Jaskiewicz
authors.forename: Halina
authors.initials: H
authors.lastname: Dziadziuszko
authors.forename: Asta
authors.initials: A
authors.lastname: Juzeniene
authors.forename: Johan
authors.initials: J
authors.lastname: Moan
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Ma
authors.forename: Rafal
authors.initials: R
authors.lastname: Peksa
authors.forename: Danuta
authors.initials: D
authors.lastname: Kunikowska
authors.forename: Alfreda
authors.initials: A
authors.lastname: Graczyk
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Kwasny
authors.forename: Miron
authors.initials: M
authors.lastname: Kaliszewski
authors.forename: Renata
authors.initials: R
authors.lastname: Glosnicka
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D000818:Animals; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D053208:Kaplan-Meier Estimate; D051379:Mice; D008815:Mice, Inbred Strains; D010212:Papilloma / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011524:Protoporphyrins / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology*; D013755:Tetradecanoylphorbol Acetate
chemical_list: D002273:Carcinogens; D017319:Photosensitizing Agents; D011524:Protoporphyrins; D015127:9,10-Dimethyl-1,2-benzanthracene; D000622:Aminolevulinic Acid; C028025:protoporphyrin IX; D013755:Tetradecanoylphorbol Acetate