title: Clinical in situ study investigating abrasive effects of two commercially available toothpastes.
abstract: The aim of this study was to determine if the abrasive effect on dentine of two commercially available toothpastes, known to vary in their in vitro abrasive levels, can be differentiated in an in situ model after 10 days, assessed by contact profilometry. This was a single centre, single blind, randomized, split mouth, two treatment, in situ study, in 34 healthy subjects, evaluating the abrasive effects of two marketed desensitizing toothpastes, (Colgate Sensitive Multi Protection toothpaste - C; Sensodyne Total Protection - S). Subjects wore bi-lateral, lower buccal appliances, each fitted with four dentine sections which were power brushed three times a day with the treatment regimen. Each subject received two toothpaste treatments for 10 days during the treatment period. Samples were measured at baseline and day 10 by contact and non-contact profilometry and day 5 by contact profilometry. Thirty-four subjects were included in the efficacy analysis. Results from contact profilometry showed statistically significant (P < 0.0001) dentine loss compared to baseline at day 5 and 10 for both pastes. At each time point, C showed statistically significantly greater dentine loss than S, P < 0.0001. After 10 days treatment, the difference in dentine loss between the pastes was 1.4 microm. The non-contact profilometry data showed similar trends. After 10 days of treatment, C showed statistically significantly greater dentine loss than S, with treatment difference of 0.9 microm, P = 0.0057. The methodology used has successfully differentiated between the abrasivity of the two pastes in respect of dentine surface loss over time in an in situ environment.
authors.affiliation: Division of Restorative Dentistry, Department of Oral and Dental Science, University of Bristol, UK.
authors.forename: A
authors.initials: A
authors.lastname: Giles
authors.forename: N C A
authors.initials: NC
authors.lastname: Claydon
authors.forename: M
authors.initials: M
authors.lastname: Addy
authors.forename: N
authors.initials: N
authors.lastname: Hughes
authors.forename: F
authors.initials: F
authors.lastname: Sufi
authors.forename: N X
authors.initials: NX
authors.lastname: West
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003743:Dental Enamel / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D013499:Surface Properties; D014072:Tooth Abrasion / Q000209:etiology*; D014077:Tooth Erosion / Q000150:complications*; D014100:Toothpastes / Q000009:adverse effects / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D014100:Toothpastes