title: Genomic analysis of one Chinese strain YS07 of infectious bursal  disease virus reveals unique genetic diversity.
abstract: The complete genome sequence of infectious bursal disease virus (IBDV) YS07 strain with low mortality isolated from Guangdong province of China in 2007 was reported in this study. The genome sequences and deduced amino acid (aa) sequences of YS07 were compared with that of previously reported IBDV strains. Phylogenetic analyses based on the deduced aa sequences of VP5, polyprotein, and VP1 protein revealed that YS07 bears its origin from European very virulent (vv) IBDV strains. Multiple aa sequences alignment revealed that YS07 contained a diversified genetic composition being characteristic to vv, variant, classical, and attenuated IBDV strains as well as its own unique ones. Our findings suggest that IBDV strains in China may gradually experience adaptive evolution due to immune pressure from intensive vaccination and demonstrate that the determination and analysis of full genome sequences is a valuable tool for studying the relationship between genetic composition and pathogenicity of IBDV strains.
authors.affiliation: State Key Lab of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors.forename: Xiangpeng
authors.initials: X
authors.lastname: Ren
authors.forename: Chunyi
authors.initials: C
authors.lastname: Xue
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Yongchang
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018175:Birnaviridae Infections / Q000821:virology; D002645:Chickens / Q000821:virology; D002681:China; D016000:Cluster Analysis; D014644:Genetic Variation; D016679:Genome, Viral; D007243:Infectious bursal disease virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D010802:Phylogeny; D011201:Poultry Diseases / Q000821:virology; D012367:RNA, Viral / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins