Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS).
To identify the location of pancreatic endocrine tumors, arterial stimulation and venous sampling (ASVS) is known to be useful for insulinoma and gastrinoma, but its usefulness for glucagonoma has not been verified to date. Here we report a case of glucagonoma that was diagnosed by ASVS with calcium loading, in which an approximately 6-fold increase of glucagon was observed in the splenic artery territory. MEN1 gene analysis verified the presence of a mutation and the glucagonoma was confirmed after operation. In conclusion, ASVS could be useful for the diagnosis of glucagonoma.
Okauchi
Yukiyoshi
Y
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita. okauchi@imed2.med.osaka-u.ac.jp
Nammo
Takao
T
Iwahashi
Hiromi
H
Kizu
Takashi
T
Hayashi
Isao
I
Okita
Kohei
K
Yamagata
Kazuya
K
Uno
Sae
S
Katsube
Fumie
F
Matsuhisa
Munehide
M
Kato
Ken
K
Aozasa
Katsuyuki
K
Kim
Tonsok
T
Osuga
Keigo
K
Nakamori
Shoji
S
Tamaki
Yasuhiro
Y
Funahashi
Tohru
T
Miyagawa
Jun-ichiro
J
Shimomura
Iichiro
I
D000368:Aged; D002118:Calcium / Q000494:pharmacology; D005260:Female; D005934:Glucagon / Q000097:blood*; D005935:Glucagonoma / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics; D009154:Mutation / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics
D005934:Glucagon; D002118:Calcium