Normal range of human red blood cell acetylcholinesterase activity.
The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean +/- SD) was 0.74 +/- 0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope +0.0008 delta pH units/hour for each year; P < 0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.
Arrieta
Daniel E
DE
Department of Animal Science, University of California-Davis, Davis, California 95616, USA.
McCurdy
Stephen A
SA
Henderson
John D
JD
Lefkowitz
Lee J
LJ
Reitstetter
Raven
R
Wilson
Barry W
BW
D000110:Acetylcholinesterase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D055815:Young Adult
D000110:Acetylcholinesterase