Gold-catalyzed synthesis of 2-aryl-3-fluoropyrroles.
The gold-catalyzed cyclization and dehydrofluorination of gem-difluorohomopropargylamines provides a novel access to 2-aryl-3-fluoropyrroles. Difluorinated homopropargylamines are prepared by the addition of gem-difluoropropargyllithium reagents to arylated N-tosylimines.
Surmont
Riccardo
R
Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
Verniest
Guido
G
De Kimpe
Norbert
N
D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
D006845:Hydrocarbons, Fluorinated; D011758:Pyrroles; D006046:Gold