The proteasome's crown for destruction.
Three recent Molecular Cell papers from Zhang et al. (2009a, 2009b) and Djuranovic et al. (2009) provide new insights into how proteasomal ATPases recognize, unfold, and translocate their substrates, thus enhancing our understanding of regulated proteolysis.
Sakata
Eri
E
Laboratory of Frontier Science, Core Technology and Research Center, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.
Saeki
Yasushi
Y
Tanaka
Keiji
K
D000251:Adenosine Triphosphatases / Q000378:metabolism / Q000502:physiology; D008958:Models, Molecular; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000502:physiology*; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism
D011506:Proteins; D046988:Proteasome Endopeptidase Complex; D000251:Adenosine Triphosphatases