title: Case report: Primary squamous cell carcinoma of a tarsal bone.
abstract: We describe a rare case of primary squamous cell carcinoma of the cuneiform bone of the foot in a 57-year-old man. In the appendicular skeleton, epithelial carcinomas of bone are usually metastatic deposits, primary squamous cell carcinomas of bone being found more frequently in the skull. A review of the English literature revealed only two other reported cases of primary squamous cell carcinoma outside the skull--one in the ilium and one in the tibia. In our patient, extensive metastatic workup and monitoring during more than 2 years showed no primary focus, supporting the rare presentation of a primary squamous cell carcinoma of bone in the appendicular skeleton.
authors.affiliation: Department of Orthopedics, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
authors.forename: Czar Louie L
authors.initials: CL
authors.lastname: Gaston
authors.forename: Ariel M
authors.initials: AM
authors.lastname: Vergel de Dios
authors.forename: Tammy L
authors.initials: TL
authors.lastname: Dela Rosa
authors.forename: Edward H M
authors.initials: EH
authors.lastname: Wang
mesh_terms: D001706:Biopsy; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D016025:Bone Transplantation; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D003475:Curettage; D006801:Humans; D007085:Ilium / Q000637:transplantation; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013639:Tarsal Bones / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome