The changes of aggregability of blood platelets in schizophrenia.
OBJECTIVE
Oxidative stress in schizophrenia may be responsible for the changes of platelet function and reactivity. Therefore, the aim of our present study was to evaluate the response of platelets from patients with schizophrenia to platelet agonists such as ADP and collagen.


RESULTS
Platelet aggregation of schizophrenic patients and healthy subjects stimulated by collagen or ADP showed significant differences. Aggregation of platelets stimulated by collagen was significantly lower in schizophrenic patients (about 86%) than in healthy subjects (P=0.022), but when this process was induced by ADP, aggregation of platelets was significantly higher in schizophrenic patients (increase to about 112%) than in healthy subjects (P=0.018). We also observed that antipsychotic drugs (clozapine, risperidone, olanzapine, haloperidol) reduce aggregation of platelets of schizophrenic patients and healthy group in vitro.


CONCLUSIONS
The obtained results indicate that the response of platelets from schizophrenic patients to ADP and collagen is different than in healthy subjects.
Dietrich-Muszalska
Anna
A
Department of Psychiatry, Medical University of Lodz, Poland. tzn_lodz@post.pl
Olas
Beata
B
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003094:Collagen / Q000494:pharmacology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D055815:Young Adult
D014150:Antipsychotic Agents; D000244:Adenosine Diphosphate; D003094:Collagen