[The effect of dosed normobaric hypoxia on physiologic regeneration of the liver parenchima in young and old rats].
We studied the effect of dosed normobaric hypoxia during 28 days on functional state and physiological regeneration of liver parenchyma. After completion of experiments in 3 and 9-month old rats we observed an increase in the amount of hepatocytes per unit of tissue area, with hypertrophied nucleus and decreased cytoplasmic area. IGF-I gene expression in 9-month old animals was increased. Thus, our study suggests that normobaric hypoxia stimulates physiological regeneration of liver parenchyma in young and adult rats.
Berezovs'kyĭ
V Ia
VIa
Ianko
R V
RV
Litovka
I H
IH
D000375:Aging; D000818:Animals; D002452:Cell Count; D022781:Hepatocytes / Q000166:cytology; D000860:Hypoxia / Q000503:physiopathology*; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D008099:Liver / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D007334:Insulin-Like Growth Factor I