Recent development in nano-sized dosage forms of plant alkaloid camptothecin-derived drugs.
DNA topoisomerase is one of drug targets in cancer therapy. Camptothecin is a plant alkaloid derived from the Chinese tree Camptotheca acuminate. It has been demonstrated that the plant alkaloid camptothecin (CPT) caused DNA damage by specifically targeting DNA topoisomerase, effectively devastating a broad spectrum of tumors. Although the anti-tumoral activity of CPT has been intensively studies for nearly fifty years, recent advances in drug delivery systems of CPT have considerably improved this drug's efficiency. In this review, we will summarize the current status of CPT-derived anti-cancer drugs in literatures and patents and highlight their clinical application.
Cuong
Nguyen-Van
NV
Department of Biomedical Engineering and R&D Center for Biomedical Microdevice Technology, Chung Yuan Christian University, 200, Chung Pei Rd., Chung Li, Taiwan 32023, R.O.C.
Hsieh
Ming-Fa
MF
Huang
Chun-Ming
CM
D000818:Animals; D002166:Camptothecin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010330:Patents as Topic
D002166:Camptothecin