title: Changes in the cytokine profile and reduced function of lymphocyte subpopulations in subacute tetrachloromethane poisoning.
abstract: Experiments on outbred albino rats showed that subacute poisoning with tetrachloromethane in a total dose of 1.0 LD50 appreciably decreased blood concentrations of cytokines (IFN-gamma, IL-2, IL-4, IL-6, IL-10), reduced the IFN-gamma/IL-4 ratio in comparison with the control, and suppressed the immune reactions, which attests to greater damage to Th1 compared to Th2 lymphocytes.
authors.affiliation: Saratov State Medical University, Russia. pz@renet.com.ru
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskii
authors.forename: V F
authors.initials: VF
authors.lastname: Kirichuk
authors.forename: V G
authors.initials: VG
authors.lastname: Lim
authors.forename: S V
authors.initials: SV
authors.lastname: Balashov
authors.forename: A A
authors.initials: AA
authors.lastname: Svistunov
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000097:blood* / Q000276:immunology; D005260:Female; D007371:Interferon-gamma / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D008297:Male; D051381:Rats; D018417:Th1 Cells / Q000166:cytology / Q000378:metabolism*; D018418:Th2 Cells / Q000166:cytology / Q000378:metabolism*
chemical_list: D007378:Interleukins; D007371:Interferon-gamma