New hope for a microRNA therapy for liver cancer.
The loss of expression of particular microRNAs can contribute to tumorigenesis. Kota et al. (2009) now explore in a mouse model a promising new approach for the treatment of liver cancer-re-establishing the expression of an miRNA using a viral vector.
Rossi
John J
JJ
Department of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. jrossi@coh.org
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000628:therapy*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005822:Genetic Vectors; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000628:therapy*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000627:therapeutic use*
D035683:MicroRNAs