Increased oxidative stress, decreased total antioxidant capacity, and iron overload in untreated patients with chronic hepatitis C.
The aim of this study was to determine oxidative stress in patients with untreated chronic hepatitis C (CHC), relating the obtained results with iron status and disease activity markers. Two groups (CHC patients and controls) were studied. CHC patients presented significantly higher values than the control group in some parameters: ALT, AST, GGT, iron, ferritin, and transferrin saturation, and also in tert-butyl hydroperoxide initiate chemiluminescence and thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter (TRAP). TBARS showed a significant correlation with serum AST and with transferrin saturation, whereas TRAP correlated inversely with serum albumin. Serum ferritin correlated with ALT and GGT, whereas serum iron did so with GGT. In conclusion, lower antioxidant capacity, higher levels of pro-oxidants activity, and iron overload occur in untreated patients with CHC. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations.
Venturini
Danielle
D
Department of Pathology, Clinical Analysis and Toxicology, University of Londrina, Londrina, Paraná, Brazil.
Simão
Andréa Name Colado
AN
Barbosa
Décio Sabbatini
DS
Lavado
Edson Lopes
EL
Narciso
Victor Emanuel Soares
VE
Dichi
Isaias
I
Dichi
Jane Bandeira
JB
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000975:Antioxidants / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood; D016166:Free Radical Scavengers / Q000097:blood; D019698:Hepatitis C, Chronic / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood; D019190:Iron Overload / Q000097:blood*; D049449:Luminescence; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012709:Serum Albumin / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000097:blood; D020122:tert-Butylhydroperoxide / Q000097:blood
D000975:Antioxidants; D016166:Free Radical Scavengers; D012709:Serum Albumin; D017392:Thiobarbituric Acid Reactive Substances; D014168:Transferrin; D005293:Ferritins; D020122:tert-Butylhydroperoxide; D007501:Iron; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase