title: Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes.
abstract: We found alpha-glucosidase inhibitory (alpha-GI) effect of metal ions and their complexes which showed the high blood glucose lowering effect in diabetic model animals. The Cu(II) ion and its complexes showed strong alpha-GI activity greater than clinically used acarbose in in vitro studies. Furthermore, in in vivo experiments, alpha-GI action was newly discovered in normal ddy mice. These results suggested that one of action mechanisms of the anti-diabetic metal ions and complexes is related to the alpha-GI effects.
authors.affiliation: Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. yutaka@mb.kyoto-phu.ac.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Ryoko
authors.initials: R
authors.lastname: Hirata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yasui
authors.forename: Hiromu
authors.initials: H
authors.lastname: Sakurai
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003300:Copper / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D009942:Organometallic Compounds; D003300:Copper