Virus vaccines and children with asthma.
OBJECTIVE
To describe what is currently known about the role of virus vaccines in the pathogenesis of asthma and atopy and summarize their role in the prevention of morbidity due to childhood asthma.


RESULTS
The development of virus vaccines and their incorporation into infant and childhood immunization programmes over the last few decades of the twentieth century have been accompanied by a striking concomitant rise in the incidence of asthma and atopy. However, a causal relationship is not supported by the majority of observational studies. The role of childhood immunization against respiratory viruses in the reduction of morbidity from asthma is another important public health issue. Recent findings suggest that influenza is not strongly associated with exacerbations of asthma in children, despite recommendations that this group should be immunized against it.


CONCLUSIONS
Current evidence suggests that virus vaccination is well tolerated and does not lead to an increased incidence of asthma or atopy in children receiving vaccines. Debate continues regarding the place of respiratory virus vaccination in the therapeutic armamentarium for children with asthma. In the case of influenza, there appears to be an absence of harm, but benefit seems to be limited to younger children.
Anderson
Mark
M
Derbyshire Children's Hospital, Derbyshire, UK.
Carroll
Will
W
D000293:Adolescent; D001249:Asthma / Q000453:epidemiology* / Q000473:pathology / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D006801:Humans; D017589:Immunization Programs; D007223:Infant; D007231:Infant, Newborn; D012141:Respiratory Tract Infections / Q000517:prevention & control* / Q000821:virology; D012307:Risk Factors; D014611:Vaccination / Q000009:adverse effects*; D014765:Viral Vaccines / Q000009:adverse effects* / Q000627:therapeutic use
D014765:Viral Vaccines