A bayesian hierarchical model for classification with selection of functional predictors.
In functional data classification, functional observations are often contaminated by various systematic effects, such as random batch effects caused by device artifacts, or fixed effects caused by sample-related factors. These effects may lead to classification bias and thus should not be neglected. Another issue of concern is the selection of functions when predictors consist of multiple functions, some of which may be redundant. The above issues arise in a real data application where we use fluorescence spectroscopy to detect cervical precancer. In this article, we propose a Bayesian hierarchical model that takes into account random batch effects and selects effective functions among multiple functional predictors. Fixed effects or predictors in nonfunctional form are also included in the model. The dimension of the functional data is reduced through orthonormal basis expansion or functional principal components. For posterior sampling, we use a hybrid Metropolis-Hastings/Gibbs sampler, which suffers slow mixing. An evolutionary Monte Carlo algorithm is applied to improve the mixing. Simulation and real data application show that the proposed model provides accurate selection of functional predictors as well as good classification.
Zhu
Hongxiao
H
Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77230, USA. hzhu1@mdanderson.org
Vannucci
Marina
M
Cox
Dennis D
DD
D016477:Artifacts; D001499:Bayes Theorem; D002965:Classification; D005260:Female; D006801:Humans; D011230:Precancerous Conditions / Q000145:classification / Q000175:diagnosis; D011237:Predictive Value of Tests; D013050:Spectrometry, Fluorescence; D002583:Uterine Cervical Neoplasms / Q000145:classification / Q000175:diagnosis