[The influence of leu-enkephalin on the bile secretion function in the rat liver during pharmacological modulation of the autonomous nervous system].
In acute experiments on rats the influence of ley-enkephalin (1 mkg/100 g) on liver bile secretion function and changes of organic contents of bile were studied. For studying the influence of opioid peptide under conditions of altered state of adreno- and cholinoreceptors, the antagonists of alpha- and beta-adrenoreceptors phentolamin (25 mkg/100 g) and obzidan (5 mkg/100 g), and the blocker of M-holinoreceptors atropine (2 mkg/100 g) were used. The pharmacological modulation of autonomous nervous systems alters the effects of ley-enkephalin on cholesecretions. Opioid peptide in the presence of antagonists of alpha-adrenoreceptors stimulates the processes of bile acids conjugation, in the presence of antagonists of beta-adrenoreceptors it cancels the effects of ley-enkephalin. The antagonists M-holinoreceptors reverse the effects of ley-enkephalin for the opposite ones: the synthesis and transport of free bile asides and cholisterine are suppressed.
Latyshenko
L A
LA
Reshetnik
Ie M
IeM
Vesel's'kyĭ
S P
SP
Makarchuk
M Iu
MIu
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000378:metabolism; D001646:Bile / Q000378:metabolism*; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D008099:Liver / Q000294:innervation / Q000378:metabolism*; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D018727:Muscarinic Antagonists; D004743:Enkephalin, Leucine