Enantioselective linchpin catalysis by SOMO catalysis: an approach to the asymmetric alpha-chlorination of aldehydes and terminal epoxide formation.
Time for SOme MOre: For the first time SOMO (singly occupied molecular orbital) activation has been exploited to allow a new approach to the alpha-chlorination of aldehydes. This transformation can be readily implemented as part of a linchpin catalysis approach to the enantioselective production of terminal epoxides.
Amatore
Muriel
M
Merck Center for Catalysis at Princeton University, Washington Road, Princeton NJ 08544-1009, USA.
Beeson
Teresa D
TD
Brown
Sean P
SP
MacMillan
David W C
DW
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry*; D054879:Halogenation; D013237:Stereoisomerism
D000447:Aldehydes; D004852:Epoxy Compounds