title: Anti-edema effects of brown seaweed (Undaria pinnatifida) extract on phorbol 12-myristate 13-acetate-induced mouse ear inflammation.
abstract: The brown seaweed Undaria pinnatifida (Harvey) Suringar is used in traditional medicine to treat fever, urination problems, lumps and swelling, and as a dietary supplement for post-childbirth women. We examined the anti-inflammatory activities of the seaweed. The methanol extract of the seaweed was active against mouse ear edema induced by phorbol myristate acetate (PMA), with an IC(50) of 10.3 mg/ml. The extract reduced the edema to a half-maximal level when applied at the concentration of 40 mg/ml within 3 hours before or 2 hours after application of PMA. Extract taken from the blade section of the seaweed demonstrated the highest activity. The Northern form of U. pinnatifida was more active than the Southern form. In the analgesic test, the methanol extract suppressed the acetic acid-induced writhing response, with an IC(50) of 0.48 g/kg body weight. The extract also demonstrated antipyretic activity in yeast-induced hyperthermic mice. Activity-related constituents were arachidonic, eicosapentaenoic, and stearidonic acids.
authors.affiliation: Department of Biotechnology, Pukyong National University, Namku, Busan 608-737, South Korea.
authors.forename: Mohammed Nurul Absar
authors.initials: MN
authors.lastname: Khan
authors.forename: Seung-Je
authors.initials: SJ
authors.lastname: Yoon
authors.forename: Jae-Suk
authors.initials: JS
authors.lastname: Choi
authors.forename: Nam Gyu
authors.initials: NG
authors.lastname: Park
authors.forename: Hyung-Ho
authors.initials: HH
authors.lastname: Lee
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Cho
authors.forename: Yong-Ki
authors.initials: YK
authors.lastname: Hong
mesh_terms: D000818:Animals; D004487:Edema / Q000517:prevention & control*; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology*; D012624:Seaweed / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D013755:Tetradecanoylphorbol Acetate