title: Predictors of health-related quality of life in patients with chronic liver disease.
abstract: BACKGROUND
  Patient-reported outcomes like health-related quality of life (HRQL) have become increasingly important for full assessment of patients with chronic liver diseases (CLD).
  
  
  OBJECTIVE
  To explore the relative impact of different types of liver disease on HRQL as well as predictors of HRQL domains in CLD.
  
  
  METHODS
  Our HRQL databases with Short-Form 36 (SF-36) data were used. Scores for each of SF-36 scales (PF - physical functioning, RP - role functioning, BP - bodily pain, GH - general health, VT - vitality, SF - social functioning, RE - role emotional and MH - mental health, MCS - mental component score, PCS - physical component score) were compared between different types of CLD as well as other variables.
  
  
  RESULTS
  Complete data were available for 1103 CLD patients. Demographic and clinical data included: age 54.2 +/- 12.0 years, 40% female, 761 (69%) with cirrhosis. Analysis revealed that age correlated significantly (P < 0.05) with worsening HRQL on every scale of the SF-36. Female patients had more HRQL impairments in PF, RP, BP, GH, VT and MH scales of SF-36 (Delta scale score: 6.6-10.7, P < 0.05). Furthermore, cirrhotic patients had more impairment of HRQL in every scale of SF-36 (Delta scale score: 6.6-43.0, P < 0.05). In terms of diagnostic groups, non-alcoholic fatty liver disease patients showed more impairment of HRQL.
  
  
  CONCLUSIONS
  Analysis of this large CLD cohort suggests that a number of important clinicodemographic factors are associated with HRQL impairment. These findings contribute to the full understanding of the total impact of CLD on patients' health.
authors.affiliation: Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Afendy
authors.forename: J B
authors.initials: JB
authors.lastname: Kallman
authors.forename: M
authors.initials: M
authors.lastname: Stepanova
authors.forename: Z
authors.initials: Z
authors.lastname: Younoszai
authors.forename: R D
authors.initials: RD
authors.lastname: Aquino
authors.forename: G
authors.initials: G
authors.lastname: Bianchi
authors.forename: G
authors.initials: G
authors.lastname: Marchesini
authors.forename: Z M
authors.initials: ZM
authors.lastname: Younossi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D011788:Quality of Life; D012720:Severity of Illness Index; D055815:Young Adult