title: Prevalence and risk factors for anaemia in pregnant women: a population-based prospective cohort study in China.
abstract: Maternal anaemia is a common pregnancy complication in developing countries; however, its epidemiology remains largely unexplored in China. This study was designed to explore the epidemiology and risk factors of anaemia during pregnancy. A prospective cohort study was conducted, using data from a population-based pregnancy-monitoring system in 13 counties in East China (1993-96). Women who delivered singleton infants at 20-44 weeks with at least one haemoglobin assessment during pregnancy were included (n = 164 667). The prevalence of anaemia (haemoglobin < 10 g/dL) during pregnancy as well as in each trimester was estimated. Multivariable log-binomial regression models were used to evaluate risk factors. The overall prevalence of anaemia in pregnancy was 32.6%, with substantial variations across trimesters (11.2%, 20.1% and 26.2% in the 1st, 2nd and 3rd trimesters respectively). Risk factors for anaemia included older maternal age, education below junior high school (prevalence rate ratio [RR] 1.10, 95% confidence interval [CI] 1.08, 1.12), farming occupation (1.05, 95% CI 1.03, 1.06), and mild pregnancy-induced hypertension (PIH) (RR 1.09, 95% CI 1.05, 1.13) and severe PIH (RR 1.13, 95% CI 1.06, 1.19). Peri-conception folic acid use was associated with a reduced risk for anaemia in the 1st trimester (RR 0.75, 95% CI 0.72, 0.78). Initiating prenatal care after the 1st trimester was associated with increased risk of anaemia in the 2nd and 3rd trimesters. Our study found anaemia during pregnancy is highly prevalent in this indigenous Chinese population. The risk increases with the severity of hypertensive disorders. Folic acid supplementation during the peri-conception period is associated with reduced risk of 1st trimester anaemia.
authors.affiliation: Merck & Co., Inc., Whitehouse Station, NJ, USA.
authors.forename: Qiaoyi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhu
authors.initials: Z
authors.lastname: Li
authors.forename: Cande V
authors.initials: CV
authors.lastname: Ananth
mesh_terms: D000328:Adult; D000740:Anemia / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D002681:China / Q000453:epidemiology; D016001:Confidence Intervals; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use*; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D011264:Pregnancy Trimesters / Q000187:drug effects; D011295:Prenatal Care / Q000379:methods; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D005492:Folic Acid