Musings on genome medicine: cholesterol and coronary artery disease.
Cholesterol levels and not inflammatory markers are the major variables that pose a risk of coronary artery disease. Diabetes greatly increases the risk at any cholesterol level. Coronary artery disease and cancer are linked by a common protein - an apoptotic protein that also functions as a regulator of insulin secretion.
Nathan
David G
DG
Dana-Farber Cancer Institute, Binney Street, Boston, MA 02115, USA. david_nathan@dfci.harvard.edu.
Orkin
Stuart H
SH