Methicillin-resistant Staphylococcus aureus (MRSA): molecular aspects of antimicrobial resistance and virulence.
Awareness of the threat of MRSA is growing. Scientists have put a lot of effort into trying to divide and classify MRSA strains into groups to better understand it. This led to the discovery that the resistance gene, mecA, and surrounding DNA could be grouped into several types. It was also discovered that the MRSA strains that caused hospital-acquired (nosocomial) infections were different strains than those seen in the communities. Several studies led to the realization that the number of MRSA infections is increasing, that more Staphylococcus aureus infections are caused by MRSA strains, and that the community strains are now showing up in the hospital. There have been government initiatives to try to decrease MRSA infections, with the most perplexing issue being that of whether or not to perform surveillance cultures on as many people as possible to eradicate MRSA from the community, as well as the hospital.
Reygaert
Wanda
W
Oakland University, School of Health Sciences, Medical Laboratory Science Program, Rochester, Michigan 48309, USA. reygaert@oakland.edu
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D007956:Leukocidins / Q000235:genetics; D016106:Methicillin Resistance / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity*; D046915:Penicillin-Binding Proteins; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D007956:Leukocidins; D046915:Penicillin-Binding Proteins; D037521:Virulence Factors; C108483:leukocidin S-component protein, Staphylococcus; C487789:mecA protein, Staphylococcus aureus