Bacterial type III effectors inhibit cell lifting by targeting integrin-linked kinase.
Many pathogenic bacteria are able to surmount exfoliation and colonize the host epithelium efficiently. In a recent article in Nature, Kim et al. (2009) show that Shigella flexneri OspE, a conserved type III effector, reinforces host cell adherence and prevents detachment of the infected cells by interacting with integrin-linked kinase.
Tegtmeyer
Nicole
N
University College Dublin, School of Biomolecular and Biomedical Sciences, Ardmore House, Belfield Campus, Dublin-4, Ireland.
Backert
Steffen
S
D001419:Bacteria / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D012763:Shigella flexneri / Q000472:pathogenicity; D037521:Virulence Factors / Q000378:metabolism*; D000099200:Scaffold Protein ILK
D001426:Bacterial Proteins; D002352:Carrier Proteins; D017346:Protein Serine-Threonine Kinases; D037521:Virulence Factors; D000099200:Scaffold Protein ILK