Taming regulatory T cells by autologous T cell immunization: a potential new strategy for cancer immune therapy.
Regulatory T cells (Tregs) play important roles in the maintenance of immune homeostasis, and is also involved in tumor immune tolerance. Dampening or elimination of Treg functions has been shown to lead to enhanced immune responses against tumors, and thus inhibition of tumor growth. Recently, we have developed a new immunization scheme, referred to as irradiated mitogen-activated autologous T cell vaccination (ATCV), and shown that such immunization could significantly enhance anti-tumor immunity in vivo. Mechanistically, the enhanced anti-tumor response appears to be due to reduced Treg functions and inhibition of activation-induced cell death (AICD) in effector T cells. Thus, ATCV may constitute a novel strategy in cancer immune therapy.
Zhang
Yan
Y
Shanghai Institute of Immunology, Institute of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Wang
Li
L
Li
Dangsheng
D
Li
Ningli
N
D000818:Animals; D015704:CD4 Antigens; D051858:Forkhead Transcription Factors; D006801:Humans; D056724:Immunity, Humoral; D016219:Immunotherapy, Adoptive; D053645:Interleukin-2 Receptor alpha Subunit; D008213:Lymphocyte Activation; D016399:Lymphoma, T-Cell / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008934:Mitogens / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D014185:Transplantation, Isogeneic; D019139:Tumor Escape
D015704:CD4 Antigens; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D053645:Interleukin-2 Receptor alpha Subunit; D008934:Mitogens