title: Transmission-dynamic model to capture the indirect effects of infant vaccination with Prevnar (7-valent pneumococcal conjugate vaccine (PCV7)) in older populations.
abstract: We developed an age-structured, transmission-dynamic, mathematical model to quantify the direct and indirect benefits of infant PCV7 vaccination. The model simulates the acquisition of asymptomatic carriage of Streptococcus pneumoniae and the development of fatal and non-fatal invasive pneumococcal disease (IPD) among vaccinated and unvaccinated individuals aged <2, 2-4, 5-17, 18-49, 50-64, and >or=65 years old. The model was parameterized using published US surveillance data, supplemented with data from published literature. The model predicts the observed incidence of IPD with good agreement and may be used to predict the impact of various vaccination strategies in the US or other populations yet to introduce PCV7.
authors.affiliation: Pharmerit North America, Bethesda, MD 20814, USA.
authors.forename: Sonya J
authors.initials: SJ
authors.lastname: Snedecor
authors.forename: David R
authors.initials: DR
authors.lastname: Strutton
authors.forename: Vincent
authors.initials: V
authors.lastname: Ciuryla
authors.forename: Elissa J
authors.initials: EJ
authors.lastname: Schwartz
authors.forename: Marc F
authors.initials: MF
authors.lastname: Botteman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002353:Carrier State / Q000276:immunology / Q000635:transmission*; D002648:Child; D002675:Child, Preschool; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D032521:Immunity, Herd; D007223:Infant; D008875:Middle Aged; D008962:Models, Theoretical; D011008:Pneumococcal Infections / Q000276:immunology / Q000635:transmission*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*; D014481:United States; D055815:Young Adult
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines