High level of alpha-synuclein mRNA in peripheral lymphocytes of patients with alcohol dependence syndrome.
The content of mRNA for alpha-synuclein (a key protein of the dopaminergic system) was elevated in the peripheral lymphocytes of patients with alcohol dependence syndrome. Increased level of alpha-synuclein mRNA was not associated with changes in the expression of NR4A2 gene encoding Nurrl, one of the main transcription factors of dopaminergic neurons.
Taraskina
A E
AE
St. Petersburg Institute of Nuclear Physics named after B. P. Konstantinov, Russian Academy of Sciences, Leningrad Region, Gatchina, Russia. ataraskina@mail.ru
Filimonov
V A
VA
Kozlovskaya
Yu A
YA
Morozova
M N
MN
Gaschin
D V
DV
Schwarzman
A L
AL
D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D000704:Analysis of Variance; D004268:DNA-Binding Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D014157:Transcription Factors / Q000235:genetics; D051844:alpha-Synuclein / Q000235:genetics*
D004268:DNA-Binding Proteins; C539882:NR4A2 protein, human; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D014157:Transcription Factors; D051844:alpha-Synuclein