title: Mechanisms of protein aggregation.
abstract: Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.
authors.affiliation: Alliance Protein Laboratories, Thousand Oaks, CA, USA. jphilo@ap-lab.com
authors.forename: John S
authors.initials: JS
authors.lastname: Philo
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Arakawa
mesh_terms: D001702:Biopharmaceutics / Q000379:methods*; D005591:Chemical Fractionation / Q000379:methods*; D008956:Models, Chemical; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000302:isolation & purification*; D011506:Proteins / Q000737:chemistry* / Q000302:isolation & purification*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D046912:Multiprotein Complexes; D011506:Proteins