[The bHLH TAL1 protein: a key molecule in the hematopoietic and endothelial systems].
The formation of blood cells and vascular networks occurs simultaneously during development, and both lineages remain in close association in all adult tissues. The functional setting of both systems within the embryo and their renewal during adult life are highly complex processes, and require the involvement of numerous molecular actors, the activities of which are often overlapping. Here, I review the activity of TAL-1, a basic-helix-loop-helix transcription factor, which plays a key role in the formation and functioning of both blood and endothelial systems, with a particular emphasis on recent data that associate TAL-1 with angiogenesis.
Mathieu
Danièle
D
Institut de Génétique Moléculaire, CNRS-UMR 5535, Universités de Montpellier 1 et Montpellier 2, 1919 route de Mende, 34293 Montpellier Cedex 1, France. danielle.mathieu@igmn.cnrs.fr
D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D051792:Basic Helix-Loop-Helix Proteins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D015820:Cadherins / Q000502:physiology; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006413:Hematopoietic System / Q000196:embryology / Q000502:physiology*; D006801:Humans; D060588:LIM Domain Proteins; D008667:Metalloproteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008958:Models, Molecular; D008969:Molecular Sequence Data; D046912:Multiprotein Complexes; D018919:Neovascularization, Physiologic / Q000235:genetics / Q000502:physiology*; D011487:Protein Conformation; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D016415:Sequence Alignment; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014158:Transcription, Genetic; D000099152:Cadherin 5
D048868:Adaptor Proteins, Signal Transducing; D015703:Antigens, CD; D051792:Basic Helix-Loop-Helix Proteins; D015820:Cadherins; D004268:DNA-Binding Proteins; D060588:LIM Domain Proteins; D008667:Metalloproteins; D046912:Multiprotein Complexes; D011518:Proto-Oncogene Proteins; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D000099152:Cadherin 5; C085117:LMO2 protein, human; C513188:Lmo2 protein, mouse; C489366:Tal1 protein, mouse; C067143:TAL1 protein, human