Sequence patches on MAPK surfaces define protein-protein interactions.
Recent studies on the modularity of mitogen-activated protein kinases show how redesigning 'surface patches' on a protein can change the topology of a signaling network.
Johnson
Gary L
GL
Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7365, USA. glj@med.unc.edu
Gomez
Shawn M
SM
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D015202:Protein Engineering
D020928:Mitogen-Activated Protein Kinases