Morphofunctional study of the therapeutic efficacy of human mesenchymal and neural stem cells in rats with diffuse brain injury.
We studied the effect of transplantation of human stem cells from various tissues on reparative processes in the brain of rats with closed craniocerebral injury. Combined treatment with standard drugs and systemic administration of xenogeneic stem cells had a neuroprotective effect. The morphology of neurons rapidly returned to normal after administration of fetal neural stem cells. Fetal mesenchymal stem cells produced a prolonged effect on proliferative activity of progenitor cells in the subventricular zone of neurogenesis. Adult mesenchymal stem cells had a strong effect on recovery of the vascular bed in ischemic regions.
Tsyb
A F
AF
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, Russia.
Yuzhakov
V V
VV
Roshal'
L M
LM
Sukhikh
G T
GT
Konoplyannikov
A G
AG
Sushkevich
G N
GN
Yakovleva
N D
ND
Ingel'
I E
IE
Bandurko
L N
LN
Sevan'kaeva
L E
LE
Mikhina
L N
LN
Fomina
N K
NK
Marei
M V
MV
Semenova
Zh B
ZhB
Konoplyannikova
O A
OA
Kal'sina
S Sh
SSh
Lepekhina
L A
LA
Semenkova
I V
IV
Agaeva
E V
EV
Shevchuk
A S
AS
Pavlova
L N
LN
Tokarev
O Yu
OY
Karaseva
O V
OV
Chernyshova
T A
TA
D000818:Animals; D001930:Brain Injuries / Q000628:therapy*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar