title: Synthesis and antiviral evaluation of 5-(1,2,3-triazol-1-ylmethyl)uridine derivatives.
abstract: Some 5-(1,2,3-triazol-1-ylmethyl)uridine derivatives were synthesized via the 1,3-dipolar cycloaddition of a 5-azidomethyluridine derivative with substituted acetylenes. The antiviral activities of these compounds against hepatitis A virus (HAV, MBB cell culture-adapted strain) and Herpes simplex virus type-1 (HSV-1) were tested.
authors.affiliation: Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt. adelnassar63@hotmail.com
authors.forename: Adel A-H
authors.initials: AA
authors.lastname: Abdel-Rahman
authors.forename: Takeshi
authors.initials: T
authors.lastname: Wada
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D000882:Haplorhini; D030041:Hepatitis A virus / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D008958:Models, Molecular; D014230:Triazoles / Q000494:pharmacology; D014529:Uridine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014709:Vero Cells; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D014230:Triazoles; D014529:Uridine