title: Antimalarial compounds from the stem bark of Vismia laurentii.
abstract: A phytochemical study of the stem bark of Vismia laurentii resulted in the isolation of a tetracyclic triterpene, tirucalla-7,24-dien-3-one (1), and seven other known compounds: 3-geranyloxyemodin (2), vismiaquinone A (3), vismiaquinone B (4), bivismiaquinone (5), epifriedelinol (6), betulinic acid (7) and stigmasta-7,22-dien-3-ol (8). The structure of all these compounds was elucidated by spectroscopic means. The stem bark extract and compounds 1 and 3 showed good antimalarial activity against the W2 strain of Plasmodium falciparum.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, TWAS Research Unit (TRU) of University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon. didetchamo@yahoo.fr
authors.forename: Diderot T
authors.initials: DT
authors.lastname: Noungoue
authors.forename: Mehdi
authors.initials: M
authors.lastname: Chaabi
authors.forename: Silvère
authors.initials: S
authors.lastname: Ngouela
authors.forename: Cyril
authors.initials: C
authors.lastname: Antheaume
authors.forename: Fabrice F
authors.initials: FF
authors.lastname: Boyom
authors.forename: Jiri
authors.initials: J
authors.lastname: Gut
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenthal
authors.forename: Annelise
authors.initials: A
authors.lastname: Lobstein
authors.forename: Etienne
authors.initials: E
authors.lastname: Tsamo
mesh_terms: D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D002163:Cameroon; D028084:Clusiaceae / Q000737:chemistry*; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology; D006801:Humans; D018547:Plant Stems / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D000962:Antimalarials; C051736:vismione A