Plectosphaeroic acids A, B, and C, indoleamine 2,3-dioxygenase inhibitors produced in culture by a marine isolate of the fungus Plectosphaerella cucumerina.
Laboratory cultures of the fungus Plectosphaerella cucumerina obtained from marine sediments collected in Barkley Sound, British Columbia, yielded the novel alkaloids plectosphaeroic acids A (1) to C (3). The alkaloids 1-3 are inhibitors of indoleamine 2,3-dioxygenase (IDO).
Carr
Gavin
G
Department of Chemistry, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
Tay
Wendy
W
Bottriell
Helen
H
Andersen
Sarah K
SK
Mauk
A Grant
AG
Andersen
Raymond J
RJ
D001955:British Columbia; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D020081:Phyllachorales / Q000737:chemistry*
D026121:Indole Alkaloids; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; C542754:plectosphaeroic acid A; C542755:plectosphaeroic acid B; C542756:plectosphaeroic acid C