title: Diversity in genes responsible for lifestyle-related diseases in Asia-Pacific region.
abstract: In Asia-Pacific countries, both environmental modernization and hereditary traits of Mongoloid reported to cause rapid increase in lifestyle-related diseases (LRD). However, reproducibility of reported responsive-factors is low. To examine this, a decision-tree method of complexity-model was applied to select LRD-responsive-factors. Genomic DNA was collected from Asia-Pacific regions. Single nucleotide polymorphisms (SNPs) on genomic DNA were determined as hereditary-trait-factor. Three indices of LRD (BMI, body fat, and serum leptin levels) were classified according to published criteria. WEKA Machine-learning system was used as decision-tree software. Age was added as a factor with different dimension. Selected factors were validated by other statistical methods. In Thai-males, GLUT) (glucose-transporter 1)-SNP was most-responsive to body fat, followed by USF1-SNP (transcription-factor for lipid metabolism). Differences between genotypes were validated (P = .002 for GLUT1 by Levene's, P = .071 for USF1 by ANOVA). Responsive-factors of Thai-females, Palau-males and Palau-females, were consisted with SNPs and age, and varied by groups. Convincing responsive-factors were not selected from mixed-data. Decision-tree-analysis successfully selected the convincing results. Responsive-factors differed by ethnic group and gender.
authors.affiliation: Division of Human Genetics, Jichi Medical University, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Yanagisawa
authors.forename: Lkhagvasuren
authors.initials: L
authors.lastname: Munkhtulga
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakayama
authors.forename: Sadahiko
authors.initials: S
authors.lastname: Iwamoto
authors.forename: Phitaya
authors.initials: P
authors.lastname: Charupoonphol
authors.forename: Somjit
authors.initials: S
authors.lastname: Supannnatas
authors.forename: Stevenson
authors.initials: S
authors.lastname: Kuartei
authors.forename: Ulziiburen
authors.initials: U
authors.lastname: Chimedregzen
authors.forename: Terue
authors.initials: T
authors.lastname: Kawabata
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Sanae
authors.initials: S
authors.lastname: Watanabe
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sakuma
authors.forename: Fumio
authors.initials: F
authors.lastname: Komatsu
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kagawa
mesh_terms: D001208:Asia; D015992:Body Mass Index; D027342:Excitatory Amino Acid Transporter 2 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D020738:Leptin / Q000097:blood; D008019:Life Style; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D019029:Palau; D020641:Polymorphism, Single Nucleotide; D051720:Upstream Stimulatory Factors / Q000235:genetics
chemical_list: D027342:Excitatory Amino Acid Transporter 2; D020738:Leptin; C497181:USF1 protein, human; D051720:Upstream Stimulatory Factors