Persistent subcutaneous nodules after immunotherapy injections for allergic asthma.
Adverse effects of desensitization injections mostly consist of local transient reactions. Rarely, persistent subcutaneous nodular lesions may also develop at the site of injection. These reactions have been attributed to the vaccines containing aluminium hydroxide. Aluminium hydroxide is used as an adjuvant in vaccines and hyposensitization solutions. We describe a patient who presented persistent, itchy subcutaneous nodules as a local reaction to allergen immunotherapy for the treatment of allergic asthma.
Ozden
Müge G
MG
Department of Dermatology, Medical Faculty, Ondokuz Mayis University, Kurupelit, Samsun, Turkey. mozden@omu.edu.tr
Kefeli
Mehmet
M
Aydin
Fatma
F
Senturk
Nilgün
N
Canturk
Tayyar
T
Turanli
Ahmet Y
AY
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000628:therapy*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D007271:Injections, Intradermal; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology*
D000276:Adjuvants, Immunologic; D000536:Aluminum Hydroxide