The effect of mitomycin C as fibrosis preventive agent during craniectomies.
OBJECTIVE
The authors conducted a study to determine the effectiveness of mitomycin C (MMC) in preventing epidural fibrosis in rats which underwent craniectomy.


METHODS
Craniectomies were performed in the right frontoparietal region; after the procedure the animals had been divided in 2 groups of 10 each. Cotton pads soaked with 0.1 mg/ml MMC or saline (control) were applied to the operative sites. Four weeks after craniectomy the rats were sacrificed, and epidural fibrosis was evaluated histologically. The dura mater thickness, the density of epidural fibrosis, arachnoidal involvement, and bone regeneration were determined.


RESULTS
No obvious adhesion formed in the rats in the MMC group, but severe epidural adhesions were found in control group. The duramater thickness, the density of epidural fibrosis, and arachnoidal involved rat number in the MMC group were significantly lower than in control groups.


CONCLUSIONS
Epidural fibrosis can be a devastating condition that forms after craniectomy. Topical application of mitomycin C may be a successful method of preventing epidural fibrosis following craniectomy.
Cemil
Berker
B
Department of Neurosurgery, Ankara Numune Education and Research Hospital, Trivandrum 695011, India. gmr@sctimst.ac.in
Tun
Kagan
K
Kaptanoglu
Erkan
E
Cevirgen
Banu
B
Gurcay
Ahmet Gurhan
AG
Kaymaz
Figen
F
Tekdemir
Ibrahim
I
D000287:Administration, Topical; D000818:Animals; D001099:Arachnoid / Q000473:pathology; D001861:Bone Regeneration; D003399:Craniotomy / Q000009:adverse effects*; D004388:Dura Mater / Q000187:drug effects / Q000473:pathology*; D005260:Female; D005355:Fibrosis; D016685:Mitomycin / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects
D016685:Mitomycin