title: Culprit-only or multivessel percutaneous coronary stenting in patients with non-ST-segment elevation acute coronary syndromes: one-year follow-up.
abstract: OBJECTIVE
  To investigate the major cardiac events at 1-year follow-up of multivessel versus culprit-vessel stenting in patients presenting with non-ST elevation acute coronary syndrome (NSTE-ACS) and multivessel disease (MVD).
  
  
  BACKGROUND
  Percutaneous coronary intervention is a standard revascularization strategy for patients with NSTE-ACS. However, when these patients have MVD it is not clear whether multivessel (MVR) is superior to culprit-vessel revascularization (CVR).
  
  
  METHODS
  We screened 1,100 consecutive patients with NSTE-ACS from an institutional database. Comparisons of 1-year outcomes between multivessel and culprit-vessel revascularized patients were made. The primary outcome was the composite (MACE) of death, myocardial infarction (MI), or any revascularization. Secondary end-points were the components of the composite end-point. Regression analysis was performed to detect predictors of MACE.
  
  
  RESULTS
  A total of 609 patients were considered for this analysis: 204 (33.5%) and 405 (66.5%) had MVR and CVR treatment, respectively. The strategy adopted was based on a clinical decision. The incidence of MACE was lower in MVR (9.45% vs. 16.34%, P = 0.02) with lower revascularization rate (7.46% vs. 13.86%, P = 0.04) than in CVR. There was no difference in death (1.99% vs. 1.98%, P = 0.8) nor death/MI (2.49% vs. 3.22%, P = 0.8) between MVR and CVR, respectively. Multivariate analysis showed CVR as the only independent predictor of improved MACE (OR 0.66, CI95% 1.12-3.47, P = 0.01).
  
  
  CONCLUSIONS
  Multivessel stenting in patients with NSTE-ACS and multivessel disease using a clinical decision of treatment is associated with lower rate of MACE driven by lower repeat revascularization, compared with culprit-vessel stenting, without difference in rates of death or MI.
authors.affiliation: Department of Cardiology, Institute Cardiovascular of Rosario, Rosario, Santa Fe, Argentina.
authors.forename: Gerardo O
authors.initials: GO
authors.lastname: Zapata
authors.forename: Leandro I
authors.initials: LI
authors.lastname: Lasave
authors.forename: Fernando
authors.initials: F
authors.lastname: Kozak
authors.forename: Anibal
authors.initials: A
authors.lastname: Damonte
authors.forename: Alejandro
authors.initials: A
authors.lastname: Meiriño
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Rossi
authors.forename: Sabrina
authors.initials: S
authors.lastname: Carbó
authors.forename: Analia
authors.initials: A
authors.lastname: Pollice
authors.forename: Ernesto
authors.initials: E
authors.lastname: Paolasso
authors.forename: Eduardo
authors.initials: E
authors.lastname: Picabea
mesh_terms: D054058:Acute Coronary Syndrome / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D003324:Coronary Artery Disease / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D015607:Stents; D013997:Time Factors