Preorganized macromolecular gene delivery systems: amphiphilic beta-cyclodextrin "click clusters".
Gene delivery systems based on the beta-cyclodextrin scaffold have been synthesized by combining the copper(I)-catalyzed azide-alkyne coupling ("click chemistry") and an efficient acylation method of the secondary hydroxyls; molecular flexibility, charge density and hydrophobic-hydrophilic balance are critical parameters that can be fine-tuned by the click approach.
Méndez-Ardoy
Alejandro
A
Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092, Sevilla, Spain.
Gómez-García
Marta
M
Ortiz Mellet
Carmen
C
Sevillano
Natalia
N
Girón
M Dolores
MD
Salto
Rafael
R
Santoyo-González
F
F
García Fernández
José M
JM
D000480:Alkynes / Q000737:chemistry; D000818:Animals; D001386:Azides / Q000737:chemistry; D016466:CHO Cells; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D018014:Gene Transfer Techniques; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
D000480:Alkynes; D001386:Azides; D046911:Macromolecular Substances; D047392:beta-Cyclodextrins; D003300:Copper; D004247:DNA; C031215:betadex