Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour models.
The penetration of anthraquinones and their platinum complexes into cancer cell spheroids reveals that they model well the distribution of such compounds in solid tumours and that the proportion of the compound that accumulates deep in the spheroid is inversely related to the rate of cellular uptake which is affected by the charge of the compound.
Bryce
Nicole S
NS
School of Chemistry, The University of Sydney, NSW 2006, Australia.
Zhang
Jenny Z
JZ
Whan
Renee M
RM
Yamamoto
Natsuho
N
Hambley
Trevor W
TW
D000880:Anthraquinones / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000378:metabolism*; D006801:Humans; D018613:Microscopy, Confocal; D009944:Organoplatinum Compounds / Q000493:pharmacokinetics*; D010984:Platinum / Q000493:pharmacokinetics; D018874:Spheroids, Cellular / Q000378:metabolism*
D000880:Anthraquinones; D009944:Organoplatinum Compounds; D010984:Platinum