Noopept reduces the postischemic functional and metabolic disorders in the brain of rats with different sensitivity to hypoxia.
Chronic cerebral ischemia was induced by ligation of both common carotid arteries in Wistar rats, divided by sensitivity to hypoxia into highly sensitive and low-sensitive. Noopept (peptide preparation), injected (0.5 mg/kg) during 7 days after occlusion of the carotid arteries, reduced the neurological disorders in rats with high and low sensitivity to hypoxia and improved their survival during the postischemic period. Noopept normalized behavior disordered by cerebral ischemia (according to the open field and elevated plus maze tests), prevented accumulation of LPO products and inhibition of antioxidant systems in the brain of rats with high and low sensitivity to hypoxia. Hence, noopept exhibited a neuroprotective effect in cerebral ischemia.
Zarubina
I V
IV
Department of Pharmacology, Military Medical Academy, Ministry of Defense of the Russian Federation, St. Petersburg, Russia. i.v.zarubina@inbox.ru
Shabanov
P D
PD
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004151:Dipeptides / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
D004151:Dipeptides; D018696:Neuroprotective Agents; C103871:ethyl phenylacetyl-Pro-Gly