title: Impact of NHC ligand conformation and solvent concentration on the ruthenium-catalyzed ring-closing metathesis reaction.
abstract: Two saturated N-heterocyclic carbene ligands with substituted naphthyl side chains were used for the preparation of Blechert-type ruthenium metathesis precatalysts. The resulting conformers of the complexes were separated and unambiguously assigned by X-ray diffraction studies. All new complexes were compared in terms of activity to the original, SIMes-derived Blechert catalyst and were shown to be superior. A study on the impact of solvent concentration in RCM reactions using the most active of these new catalysts ultimately led to the ring closing of a variety of substrates at very low catalyst loadings.
authors.affiliation: Organic Chemistry Institute, University of Zurich (UZH), Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
authors.forename: Michele
authors.initials: M
authors.lastname: Gatti
authors.forename: Ludovic
authors.initials: L
authors.lastname: Vieille-Petit
authors.forename: Xinjun
authors.initials: X
authors.lastname: Luan
authors.forename: Ronaldo
authors.initials: R
authors.lastname: Mariz
authors.forename: Emma
authors.initials: E
authors.lastname: Drinkel
authors.forename: Anthony
authors.initials: A
authors.lastname: Linden
authors.forename: Reto
authors.initials: R
authors.lastname: Dorta