C-C chemokine receptor 2 expression by circulating monocytes influences atherosclerosis in patients on chronic hemodialysis.
Mortality from cardiovascular or cerebrovascular disease due to atherosclerosis is increased in patients on chronic hemodialysis. Monocyte chemoattractant protein-1 and its receptor, C-C chemokine receptor 2, play an important role in recruiting monocytes to atherosclerotic lesions. The relationship between atherosclerosis in hemodialysis patients and C-C chemokine receptor 2 expression is unknown. Fifty-six patients on chronic hemodialysis and 27 age- and sex-matched controls were enrolled. Serum levels of monocyte chemoattractant protein-1 and expression of C-C chemokine receptor 2 by circulating monocytes were determined. Atherosclerosis was evaluated from the carotid intima-media thickness and cardio-ankle vascular index. Serum levels of monocyte chemoattractant protein-1 and expression of C-C chemokine receptor 2 by monocytes were significantly higher in the hemodialysis patients than the controls. Multiple regression analysis showed a positive correlation between receptor expression and both indexes of atherosclerosis. C-C chemokine receptor 2 expression by circulating monocytes influences atherosclerosis in patients on chronic hemodialysis.
Okumoto
Satoshi
S
Department of Molecular and Internal Medicine, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.
Taniguchi
Yoshihiko
Y
Nakashima
Ayumu
A
Masaki
Takao
T
Ito
Takafumi
T
Ogawa
Takahiko
T
Takasugi
Norihisa
N
Kohno
Nobuoki
N
Yorioka
Noriaki
N
D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D002339:Carotid Arteries / Q000473:pathology; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D054390:Receptors, CCR2 / Q000235:genetics / Q000378:metabolism*; D012044:Regression Analysis; D006435:Renal Dialysis / Q000009:adverse effects; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology
D018932:Chemokine CCL2; D054390:Receptors, CCR2