title: Comparative studies and identification of camptothecin produced by an endophyte at shake flask and bioreactor.
abstract: The fungus showing homology with Nodulisporium by 28S ribosomal gene sequencing, which has been discovered as an endophyte on medicinal plant Nothapodytes foetida, was found to produce 45 and 5.5 microg of camptothecin (CPT) per gram of mycelia at bioreactor and at shake flask, respectively, which was further quantified and characterised by various spectroscopic analyses.
authors.affiliation: Indian Institute of Integrative Medicine (CSIR), Sanatnagar, Srinagar, India. suriyamir@yahoo.com
authors.forename: Suriya
authors.initials: S
authors.lastname: Rehman
authors.forename: A S
authors.initials: AS
authors.lastname: Shawl
authors.forename: Amardeep
authors.initials: A
authors.lastname: Kour
authors.forename: Phalisteen
authors.initials: P
authors.lastname: Sultan
authors.forename: Khurheed
authors.initials: K
authors.lastname: Ahmad
authors.forename: Ravi
authors.initials: R
authors.lastname: Khajuria
authors.forename: G N
authors.initials: GN
authors.lastname: Qazi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000096:biosynthesis* / Q000302:isolation & purification; D001203:Ascomycota / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D019149:Bioreactors; D002166:Camptothecin / Q000096:biosynthesis* / Q000302:isolation & purification; D004271:DNA, Fungal / Q000235:genetics; D005285:Fermentation; D010946:Plants, Medicinal / Q000382:microbiology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004271:DNA, Fungal; D002166:Camptothecin