Effect of lysosomotropic form of amphotericin B on functional state of phagocytes in experimental candidiasis.
Effect of antifungal preparation amphotericin B and its lysosomotropic composition with dialdehyde-dextran on functional state of phagocytizing cells in the dynamics of granulomatous inflammation induced by C. albicans was studied on CBA mice. A stimulating effect of amphotericin B on the production of reactive oxygen species by peritoneal and bone marrow phagocytes was observed, while lysosomotropic form of the antibiotic did not stimulate generation of oxygen radicals.
Kurilin
V V
VV
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Russia. medinfo@ngs.ru
Saperova
M A
MA
Efanov
E A
EA
Tsyrendorzhiev
D D
DD
Shkurupiy
V A
VA
D000666:Amphotericin B / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D004195:Disease Models, Animal; D051379:Mice; D010586:Phagocytes / Q000187:drug effects* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
D000935:Antifungal Agents; D017382:Reactive Oxygen Species; D000666:Amphotericin B