Effects of decabrominated diphenyl ether (PBDE 209) exposure at different developmental periods on synaptic plasticity in the dentate gyrus of adult rats In vivo.
Polybromininated diphenyl ethers (PBDEs) are widely used as flame-retardant additives. Previous studies have demonstrated that PBDEs exposure can lead to neurotoxicity. However, little is known about the effects of PBDE 209 on synaptic plasticity. This study investigated the effect of decabrominated diphenyl ether (PBDE 209), a major PBDEs product, on synaptic plasticity in the dentate gyrus of rats at different developmental periods. We examined the input/output functions, paired-pulse reactions, and the long-term potentiation of the field excitatory postsynaptic potential slope and the population spike amplitude in vivo. Rats were exposed to PBDE 209 during five different developmental periods: pregnancy, lactation via mother's milk, lactation via intragastric administration, after weaning, and prenatal to life. We found that exposed to PBDE 209 during different developmental periods could impair the synaptic plasticity of adult rats in different degrees. The results also showed that PBDE 209 might cause more serious effects on the postsynaptic cell excitability in synaptic plasticity, and the lactation period was the most sensitive time of development towards PBDE 209.
Xing
Tairan
T
School of Life science, University of Science and Technology of China, Hefei, Anhui, 230027 PR China.
Chen
Liang
L
Tao
Yanan
Y
Wang
Ming
M
Chen
Jutao
J
Ruan
Di-Yun
DY
D000375:Aging; D000818:Animals; D018891:Dentate Gyrus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000503:physiopathology; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials; D005260:Female; D005411:Flame Retardants / Q000378:metabolism / Q000633:toxicity*; D005865:Gestational Age; D055768:Halogenated Diphenyl Ethers / Q000378:metabolism / Q000633:toxicity*; D007774:Lactation; D017774:Long-Term Potentiation / Q000187:drug effects*; D020258:Neurotoxicity Syndromes / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; C010902:decabromobiphenyl ether