title: Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135).
abstract: Severe acute hepatitis of unknown etiology is difficult to treat and often progresses to subacute fulminant hepatitis or late-onset hepatic failure. A 45-year-old well-nourished, healthy man had progressive fatigue and his liver function tests showed severe liver dysfunction. The etiology of sever acute cholestatic hepatitis was unknown. The liver function tests normalized gradually, which excluded high persistent total bilirubin after starting on predonine. A liver biopsy showed chronic active hepatitis with mild fibrosis (A2, F1). Oral Inchinko-to, a Chinese herbal medicine, at 7.5 g daily was prescribed. The treatment was effective with no adverse effects. We present a successfully treated case and discuss hepatoprotective and choleretic effects of Inchinko-to.
authors.affiliation: Kanetsu Chuo Hospital, Takasaki, Gunma, Japan. gogoohwada@yahoo.co.jp
authors.forename: Susumu
authors.initials: S
authors.lastname: Ohwada
authors.forename: Isao
authors.initials: I
authors.lastname: Kobayashi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Harasawa
authors.forename: Kyoichiro
authors.initials: K
authors.lastname: Tsuda
authors.forename: Yosikatsu
authors.initials: Y
authors.lastname: Inui
mesh_terms: D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002780:Cholestasis, Intrahepatic / Q000188:drug therapy / Q000209:etiology; D004365:Drugs, Chinese Herbal; D005704:Gallbladder / Q000473:pathology; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D002756:Cholagogues and Choleretics; D004365:Drugs, Chinese Herbal; C078038:inchinko-to