Challenges of functional imaging research of pain in children.
Functional imaging has revolutionized the neurosciences. In the pain field it has dramatically altered our understanding of how the brain undergoes significant functional, anatomical and chemical changes in patients with chronic pain. However, most studies have been performed in adults. Because functional imaging is non-invasive and can be performed in awake individuals, applications in children have become more prevalent, but only recently in the pain field. Measures of changes in the brains of children have important implications in understanding neural plasticity in response to acute and chronic pain in the developing brain. Such findings may have implications for treatments in children affected by chronic pain and provide novel insights into chronic pain syndromes in adults. In this review we summarize this potential and discuss specific concerns related to the imaging of pain in children.
Sava
Simona
S
P.A.I.N. Group, Department of Radiology, Children's Hospital Boston, Massachuesetts, USA. Simona.Sava@childrens.harvard.edu
Lebel
Alyssa A
AA
Leslie
David S
DS
Drosos
Athena
A
Berde
Charles
C
Becerra
Lino
L
Borsook
David
D
D001931:Brain Mapping; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010146:Pain / Q000473:pathology / Q000503:physiopathology; D019265:Spectroscopy, Near-Infrared / Q000379:methods*