title: [Case of pemetrexed-induced acute lung injury].
abstract: A 65-year-old man was admitted with dyspnea. Chest radiograph showed left pleural effusion and chest CT scan revealed multiple left pleural masses. The diagnosis of malignant pleural mesothelioma was made by CT-guided needle biopsy. He received the combination chemotherapy with pemetrexed and carboplatin. The day after initiating chemotherapy, he had fever and dyspnea. Chest CT scan showed diffuse ground glass opacities mainly in the right lung, suggestive of drug-induced interstitial pneumonia. Corticosteroid pulse therapy was started, but he died of respiratory failure 10 days after beginning chemotherapy. This is apparently the first reported case of pemetrexed-induced acute lung injury.
authors.affiliation: Department of Respiratory Medicine, Toho University School of Medicine.
authors.forename: Susumu
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Kyohei
authors.initials: K
authors.lastname: Kaburaki
authors.forename: Shinji
authors.initials: S
authors.lastname: Sakaguchi
authors.forename: Go
authors.initials: G
authors.lastname: Sano
authors.forename: Keishi
authors.initials: K
authors.lastname: Sugino
authors.forename: Kazunori
authors.initials: K
authors.lastname: Isobe
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shibuya
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kurosaki
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Uekusa
authors.forename: Sakae
authors.initials: S
authors.lastname: Homma
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced* / Q000000981:diagnostic imaging; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D016190:Carboplatin / Q000008:administration & dosage; D017809:Fatal Outcome; D005971:Glutamates / Q000008:administration & dosage / Q000009:adverse effects*; D006147:Guanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy*; D000068437:Pemetrexed; D010997:Pleural Neoplasms / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D016190:Carboplatin