A biomarker for exposure to organophosphate and carbamate pesticides.
A cross sectional study was conducted to investigate the effects of pesticide exposure (organophosphate and carbamate) using nerve conductive velocity, current perception threshold (CPT). Cluster random sampling was employed to recruit 64 paddy farmers and 22 fishermen in June 2006. The duration of pesticide exposure was between (5-20) years. The CPT values were measured using Neurometer CPT/Eagle, on the index finger and the great toe with three neuroselective frequencies range (2000, 250, and 5 Hz). The results showed that at the three different frequencies, the CPT values were significantly elevated among farmers on both the medial and peroneal nerves (P < .002). The measurement of CPT can be used as a biomarker to determine and monitor the effects of organophosphate and carbamate exposure among workers who may have been exposed.
Lubis
Syarif Husin
SH
Department of Biomedical, School of Allied Health Science, UKM, Malaysia. saginov25@hotmail.com
El Sersi
Magdi
M
Hussein
Salmaan Hussein Inayat
SH
Sakian
Noor Ibrahim
NI
Salleh
Rahim
R
Rafai
Jamil
J
Al Khamesey
Khaled
K
D000328:Adult; D000368:Aged; D000382:Agricultural Workers' Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D000383:Agriculture; D002219:Carbamates / Q000506:poisoning*; D003430:Cross-Sectional Studies; D005398:Fisheries; D006801:Humans; D008296:Malaysia; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects* / Q000502:physiology; D016273:Occupational Exposure; D062025:Organophosphate Poisoning; D010525:Peripheral Nerves / Q000187:drug effects* / Q000503:physiopathology; D010575:Pesticides / Q000506:poisoning*; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D055815:Young Adult
D002219:Carbamates; D010575:Pesticides