No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.
The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased alpha-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific.
Halliday
Glenda
G
Prince of Wales Medical Research Institute and School of Medical Sciences, Faculty of Medicine University of New South Wales, Sydney, Australia. g.halliday@powmri.edu.au
Herrero
Maria Trinidad
MT
Murphy
Karen
K
McCann
Heather
H
Ros-Bernal
Francisco
F
Barcia
Carlos
C
Mori
Hideo
H
Blesa
Francisco J
FJ
Obeso
José A
JA
D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D016631:Lewy Bodies / Q000473:pathology*; D008137:Longitudinal Studies; D020267:MPTP Poisoning / Q000378:metabolism / Q000473:pathology*; D008252:Macaca fascicularis; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D051844:alpha-Synuclein / Q000378:metabolism
D051844:alpha-Synuclein; D014446:Tyrosine 3-Monooxygenase