title: Troponin T predicts in-hospital and 1-year mortality in patients with pulmonary embolism.
abstract: We aimed to determine the prognostic value of troponin T (TNT) for in-hospital and 1-yr mortality in a large sample of patients with pulmonary embolism (PE). Patients presenting at the emergency department of a tertiary care centre from January 1998 to December 2006 with PE were included. A blood sample was taken at the time of presentation. To determine in-hospital and 1-yr mortality, data from the hospital records and the national death register were used. TNT was determined in 563 out of 737 patients with proven PE. TNT was elevated (>0.03 ng x mL(-1)) in 27%. In-hospital survival was 79% in TNT-positive patients compared with 94% in TNT-negative patients (p<0.001). 1-yr survival was 71% in TNT-positive patients compared with 90% in TNT-negative patients (p<0.001). Elevated TNT levels meant a four-times higher risk of in-hospital death and a three-times higher risk of 1-yr mortality, even after adjustment for the other most important risk factors of death in this population. Elevated TNT independently predicts in-hospital and 1-yr mortality in patients with acute PE.
authors.affiliation: Dept of Emergency Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. karin.janata@meduniwien.ac.at
authors.forename: K M
authors.initials: KM
authors.lastname: Janata
authors.forename: J M
authors.initials: JM
authors.lastname: Leitner
authors.forename: N
authors.initials: N
authors.lastname: Holzer-Richling
authors.forename: A
authors.initials: A
authors.lastname: Janata
authors.forename: A N
authors.initials: AN
authors.lastname: Laggner
authors.forename: B
authors.initials: B
authors.lastname: Jilma
mesh_terms: D004636:Emergency Service, Hospital; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007118:Immunoassay / Q000379:methods; D049449:Luminescence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D011655:Pulmonary Embolism / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D016896:Treatment Outcome; D020107:Troponin T / Q000097:blood*
chemical_list: D020107:Troponin T