title: [Juvenile fibroadenomas in a girl with serious aplastic anaemia after immunoablative treatment - case report].
abstract: We report a 17-year old girl, with severe aplastic anaemia (SAA)and juvenile fibroadenoma. She was treated with immunoablative therapy (IST), due to lack of a family bone marrow donor. She did not respond to the first course of IST. We administered second course of IST (ATG+CSA), because there was also no unrelated bone marrow donor. In January 2007 (1 year after starting CSA treatment), a palpable mass was found in the left breast.USG examination, performed after 2 months of observation, confirmed the presence of numerous lesions in the left and right breast (suggested fibroadenoma). Diagnostic biopsy was not performed due to high risk of bleeding. During a two step operation the biggest lesions were excised. Histopathological examination confirmed the diagnosis juvenile fibroadenoma of on physical examination, 8 months after the operation, there are again palpable nodular lesions in the left breast. (USG suggests fibroadenoma) The girl remains under systematic control. Now she has partially responded after second course of IST. Juvenile fibroadenoma of the breast in our patient may be a side effect of CSA therapy (she was treated with CSA for 2 years).
authors.affiliation: Katedra i Klinika Pediatrii, Hematologii i Onkologii WUM w Warszawie, ul. Marszałkowska 24, 00-576 Warszawa, Poland. katpawelec@poczta.onet.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Pawelec
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Salamonowicz
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000188:drug therapy*; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D018226:Fibroadenoma / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine