title: [Bioelectical impedance analysis for comparison of the body composition in type 1 diabetes patients, obese patients and healthy volunteers].
abstract: BACKGROUND
  Effects ofglycaemic control and insulin treatment on body composition in type 1 diabetes patients have not been clearly proven yet.
  
  
  OBJECTIVE
  Comparison of the body composition in type 1 diabetes patients, obese patients and healthy volunteers using multifrequency bioelectrical impedance analysis.
  
  
  METHODS
  Multifrequency bioelectrical impedance measurements were performed on 153 type 1 diabetes patients, 176 obese patients and on 159 healthy controls of the same age and gender. HbA1c level, duration of disease and daily dose of insulin were measured in diabetes patients.
  
  
  RESULTS
  Significant differences were observed in body composition between obese patients and both type 1 diabetes patients and healthy controls. Higher fat mass (FM) and body cell mass (BCM) and lower lean body mass (LBM) were observed in obese patients. Only a higher reactance by the healthy controls (56.75 Omega +/- 11.22 vs 53.27 Omega +/- 7.97, p < 0.05) was observed between type 1 diabetes patients and healthy controls. No significant differences were observed in other parameters of body composition between these two groups. HbA1c level negatively correlated with LBM in the diabetes patients. The duration of disease negatively correlated with BCM. And a negative correlation was also found between daily dose of insulin (IU/kg) and weight and LBM.
  
  
  CONCLUSIONS
  The treated type 1 diabetes does not influence the body composition. We found a negative correlation between HbA1c level and LBM, between duration ofdisease and BCM and between daily dose ofinsulin and weight and LBM. Higher FM and BCM was observed in obese patients, lower LBM is due to the abnormally high level in diabetes patients and healthy controls.
authors.affiliation: Diabetologické centrum I. interní kliniky Lékarské fakulty UKa FN Plzen.
authors.forename: L
authors.initials: L
authors.lastname: Baxová
authors.forename: M
authors.initials: M
authors.lastname: Zourek
authors.forename: V
authors.initials: V
authors.lastname: Frantová
authors.forename: K
authors.initials: K
authors.lastname: Kovárová
authors.forename: Z
authors.initials: Z
authors.lastname: Rusavý
mesh_terms: D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000473:pathology*; D017097:Electric Impedance; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D009765:Obesity / Q000473:pathology*
chemical_list: D006442:Glycated Hemoglobin