cIAP proteins: keystones in NOD receptor signal transduction.
NOD1 and 2 are intracellular sentinels critical to innate immunity. In this issue of Immunity, Bertrand et al. (2009) fill in a gap in the NOD signaling cascade by demonstrating that cIAP1 and 2 function as E3 ubiquitin ligases for the RIP2 signaling molecule.
Reardon
Colin
C
Campbell Family Cancer Research Institute, Princess Margaret Hospital, Toronto, ON, Canada. creardon@uhnres.utoronto.ca
Mak
Tak W
TW
D000818:Animals; D000075747:Baculoviral IAP Repeat-Containing 3 Protein; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D007113:Immunity, Innate; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D053474:Nod1 Signaling Adaptor Protein / Q000276:immunology / Q000378:metabolism*; D053473:Nod2 Signaling Adaptor Protein / Q000276:immunology / Q000378:metabolism*; D053475:Receptor-Interacting Protein Serine-Threonine Kinase 2; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D044767:Ubiquitin-Protein Ligases / Q000276:immunology / Q000378:metabolism*
D016207:Cytokines; D051034:Inhibitor of Apoptosis Proteins; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D000075747:Baculoviral IAP Repeat-Containing 3 Protein; C494834:Birc2 protein, mouse; C494835:Birc3 protein, mouse; D044767:Ubiquitin-Protein Ligases; D053475:Receptor-Interacting Protein Serine-Threonine Kinase 2; D053422:Receptor-Interacting Protein Serine-Threonine Kinases; C506255:Ripk2 protein, mouse