Biodegradable polymer films for releasing nanovehicles containing sirolimus.
To obtain novel biodegradable sirolimus-releasing polymer films that could release nanovehicles incorporating sirolimus, polyester, a water-soluble amphiphilic phospholipid polymer, and sirolimus were blended. The sirolimus-releasing polymer films were characterized by scanning electron microscopy and differential scanning calorimetry. Nanovehicles were formed with the phospholipid polymer chains and could be released from the sirolimus-releasing polymer films. The hydrodynamic diameter of the nanovehicles in phosphate-buffered saline was smaller than 20 nm. The nanovehicles substantially enhanced the carrier-mediated delivery of sirolimus and attenuated its degradation product. This study demonstrates that the delivery of sirolimus was enhanced by nanovehicles released from sirolimus-eluting materials.
Kim
Hyung Il
HI
Department of Bioengineering, The University of Tokyo, Japan.
Takai
Madoka
M
Konno
Tomohiro
T
Matsuno
Ryosuke
R
Ishihara
Kazuhiko
K
D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D054855:Drug-Eluting Stents; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D020123:Sirolimus / Q000737:chemistry* / Q000493:pharmacokinetics; D014867:Water / Q000737:chemistry
D004337:Drug Carriers; D011108:Polymers; D014867:Water; D020123:Sirolimus