[Progress of human gene therapy].
Much attention has been paid to gene therapy since 1990's. No remarkable success has been achieved and several serious adverse effects such as leukemia in X-SCID gene therapy have been reported. Nevertheless, trials to treat hereditary disease, cancers and cardiovascular disease using therapeutic gene-loaded vectors are continuously being performed. Recently, some gene drugs such as p53-loaded adenovirus vector, oncolytic adenovirus and HGF plasmid DNA are produced and remain to be commercially available. Stem cell-based gene therapy will be main focus in hereditary disease gene therapy. In cancer gene therapy, regulation of anti-tumor immunity and improvement of gene-modified oncolytic virus will be more fully investigated.
Kaneda
Yasufumi
Y
Division of Gene Therapy Science, Graduate School of Medicine, Osaka University.
D030342:Genetic Diseases, Inborn / Q000628:therapy; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D014652:Vascular Diseases / Q000628:therapy