title: Avascular osteonecrosis after treatment of SARS: a 3-year longitudinal study.
abstract: OBJECTIVE
  To investigate the relationship between avascular osteonecrosis (AVN) and corticosteroid treatment given to patients with severe acute respiratory syndrome (SARS).
  
  
  METHODS
  Longitudinal study of 71 former SARS patients (mainly health care workers) who had been treated with corticosteroids, with an observation time of 36 months. Magnetic resonance images (MRI) and X-rays of hips, knees, shoulders, ankles and wrists were taken as part of the post-SARS follow-up assessments.
  
  
  RESULTS
  Thirty-nine per cent developed AVN of the hips within 3-4 months after starting treatment. Two more cases of hip necrosis were seen after 1 year and another 11 cases of AVN were diagnosed after 3 years, one with hip necrosis and 10 with necrosis in other joints. In total, 58% of the cohort had developed AVN after 3 years of observation. The sole factor explaining AVN in the hip was the total dose of corticosteroids received.
  
  
  CONCLUSIONS
  The use of corticosteroids in SARS has been debated; opinions conflict about whether the immediate benefits in terms of saving lives compensate for the adverse effects, including AVN.
authors.affiliation: Chinese People's Armed Forces (CPAF) Hospital of Beijing, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lv
authors.forename: Sake J
authors.initials: SJ
authors.lastname: de Vlas
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Tian-Bao
authors.initials: TB
authors.lastname: Wang
authors.forename: Zhao-Yang
authors.initials: ZY
authors.lastname: Cao
authors.forename: Chun-Peng
authors.initials: CP
authors.lastname: Li
authors.forename: Wu-Chun
authors.initials: WC
authors.lastname: Cao
authors.forename: Jan Hendrik
authors.initials: JH
authors.lastname: Richardus
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010020:Osteonecrosis / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G; D011239:Prednisolone