title: Influence of extracorporeal membrane oxygenation on subsequent surgeries after congenital diaphragmatic hernia repair.
abstract: OBJECTIVE
  Congenital diaphragmatic hernia (CDH) is a complex anomaly requiring intensive pulmonary and hemodynamic management. Survival has increased in this population placing them at risk for subsequent morbidities including surgery. The purpose of this study is to review the need for subsequent surgeries in the CDH population.
  
  
  METHODS
  After receiving institutional review board approval, a retrospective chart review of all CDH patients between 1980 and 2007 was conducted noting subsequent surgeries and the impact of extracorporeal membrane oxygenation (ECMO) on the types of surgical procedures. Comparison of groups was done by Fisher's Exact test or nonparametric Wilcoxon rank-sum test where appropriate. A P value of less than .05 was considered significant.
  
  
  RESULTS
  Data were analyzed for 227 of 294 patients during this period. Extracorporeal membrane oxygenation support was used in 45% of patients. Subsequent surgery was required in 117 patients. Seventy patients in the ECMO group (69%) required a subsequent operation. The most common operative procedures included inguinal hernia/orchiopexy, antireflux, and recurrent diaphragmatic hernias.
  
  
  CONCLUSIONS
  In this series, ECMO survivors are at a high risk for requiring subsequent surgeries compared to the total CDH group. This information can be used as an education tool for referring physicians and parents as they care for this group of children.
authors.affiliation: Division of Pediatric Surgery, Riley Hospital for Children, Indianapolis, Ind 46202, USA.
authors.forename: Francine D
authors.initials: FD
authors.lastname: Breckler
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Molik
authors.forename: Karen W
authors.initials: KW
authors.lastname: West
mesh_terms: D015199:Extracorporeal Membrane Oxygenation; D018662:Fundoplication; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000601:surgery*; D006552:Hernia, Inguinal / Q000150:complications / Q000601:surgery; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies