title: Long-term myocardial functional improvement after autologous bone marrow mononuclear cells transplantation in patients with ST-segment elevation myocardial infarction: 4 years follow-up.
abstract: OBJECTIVE
  To evaluate the safety profile and efficacy of bone marrow mononuclear cells (BMMNC) transplantation for ST-segment elevation myocardial infarction (STEMI) by assessing patients and their left ventricular function at up to 4 years follow-up.
  
  
  RESULTS
  Eighty-six patients with STEMI who had successfully undergone percutaneous coronary intervention (PCI) were randomized to receive intracoronary injection of BMMNC (n = 41) or saline (n = 45). Left ventricular ejection fraction, as evaluated by UCG, was markedly improved at 6 months (0.484 +/- 0.5 vs. 0.457 +/- 0.6, P = 0.001), 1 year (0.482 +/- 0.7 vs. 0.446 +/- 0.6, P < 0.001), and 4 years (0.505 +/- 0.8 vs. 0.464 +/- 0.8, P < 0.001) after BMMNC transplant when compared with control group. However, the current cell therapy did not improve the myocardial viability of the infarcted area as assessed by single-photon emission computed tomography analysis at 4 years post-transplant (0.263 +/- 0.007 in BMMNC group vs. 0.281 +/- 0.008 in control group, P = 0.10). During the follow-up period, one control group case (2.2%) of in-stent restenosis was confirmed by coronary angiography and underwent repeat PCI. Also during follow-up, one death (2.2%) occurred in the control group, and one patient (2.4%) in the BMMNC group had transient acute heart failure.
  
  
  CONCLUSIONS
  This study indicates that intracoronary delivery of autologous BMMNC is safe and feasible for STEMI patients who have undergone PCI, and can lead to long-term improvement in myocardial function.
authors.affiliation: Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. wind8828@gmail.com
authors.forename: Feng
authors.initials: F
authors.lastname: Cao
authors.forename: Dongdong
authors.initials: D
authors.lastname: Sun
authors.forename: Chengxiang
authors.initials: C
authors.lastname: Li
authors.forename: Kazim
authors.initials: K
authors.lastname: Narsinh
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Xuyang
authors.initials: X
authors.lastname: Feng
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Duan
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Dingjing
authors.initials: D
authors.lastname: Liu
authors.forename: Haichang
authors.initials: H
authors.lastname: Wang
mesh_terms: D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D016026:Bone Marrow Transplantation / Q000379:methods*; D023921:Coronary Stenosis / Q000209:etiology; D004452:Echocardiography; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000601:surgery*; D049268:Positron-Emission Tomography; D020127:Recovery of Function; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology