Sensitivity of adrenal glands to adrenocorticotropic hormone in animals with alimentary obesity.
Blood concentration of corticosterone in obese rats did not differ from the control value. In vitro synthesis of progesterone and corticosterone in adrenal slices from obese rats was lower compared to control animals, but these differences disappeared after addition of adrenocorticotropic hormone to the incubation medium. In obese rats, blood content of corticosterone in response to administration of adrenocorticotropic hormone in vivo increased by 8 times, while in control animals this parameter increased by only 4.5 times.
Pankina
T V
TV
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Kuzminova
O I
OI
Selyatitskaya
V G
VG
D000305:Adrenal Cortex Hormones / Q000097:blood* / Q000378:metabolism*; D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D006728:Hormones / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009765:Obesity / Q000378:metabolism*; D051381:Rats
D000305:Adrenal Cortex Hormones; D006728:Hormones; D000324:Adrenocorticotropic Hormone