title: [A case report of acute Q fever showing Kawasaki disease-like symptoms in a 9-year-old girl].
abstract: A 9-year-old girl developing fever and hyperemia of both bulbar conjunctiva 5 days before admission to the Saitama Children's Medical Center after antibiotics proved ineffective was found on admission to have general fatigue and a temperature of 39 degrees C. Physical examination showed hyperemia of the bulbar conjunctiva, fissures of the lips, redness of the pharynx, and swelling of the cervical lymph nodes. Laboratory tests detected neutrophilia (11,200/microL), mild anemia (11.4g/dL), thrombocytopenia (110,000/microL), and elevated serum aspartate aminotransferase (242IU/L), alanine aminotransferase (328IU/L), and C-rective protein (25.2 mg/dL). Autoantibodies such as anti-nuclear, anti-SS-A/Ro, and anti-Jo-1 were also found. Echocardiography showed no abnormality of the coronary arteries. She was diagnosed as having incomplete Kawasaki disease on day 7 of illness, necessitating that a high dose of immunoglobulin be given intravenously. Her temperature dropped temporarily to 37 degrees C, but she developed erythema of the cheek and fever. Intravenous immunoglobulin was restarted, and minocycline introduced because her daily contact with a pet cat indicated richettsial infection such as Q fever. Mild fever, muscle pain, and elevated C-reactive protein did not improve, but clinical signs and symptoms gradually lessened after ibuprofen was given, then disappeared. A definitive diagnosis of Q fever was made through an over 4-fold rise in phase II IgG antibody titers against Coxiella burnetii, titer of less than 1 : 16 on day 14 of illness, and titer of 1 : 256 on day 34. This case study describes on atypical case of Q fever with clinical manifestations mimicking Kawasaki disease.
authors.affiliation: Division of Infectious Disease, Immunology, and Allergy, Saitama Children's Medical Center.
authors.forename: Chikara
authors.initials: C
authors.lastname: Ohgimi
authors.forename: Risa
authors.initials: R
authors.lastname: Tanaka
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Oh-ishi
mesh_terms: D000208:Acute Disease; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis*; D011778:Q Fever / Q000175:diagnosis*