title: In vivo acute toxicological studies of an antioxidant extract from Mangifera indica L. (Vimang).
abstract: Mango (Mangifera indica L.) stem bark aqueous extract (MSBE) is a natural product with antioxidant, anti-inflammatory, analgesic, and immunomodulatory effects. Its formulations (e.g., tablets, capsules, syrup, vaginal oval, and suppositories) are known by the brand name of Vimang. In view of the ethnomedical, preclinical, and clinical uses of this extract and the necessity to assess its possible toxicological effect on man, a toxicological analysis of a standard extract is reported in this paper. Acute toxicity was evaluated in mice and rats by oral, dermal, and intraperitoneal (i.p.) administration. The extract, by oral or dermal administration, showed no lethality at the limit doses of 2,000 mg/kg body weight and no adverse effects were found. Deaths occurred with the i.p. administration at 200, but not 20 mg/kg in mice. MSBE was also studied on irritant tests in rabbits, and the results showed that it was nonirritating on skin, ocular, or rectal mucosa. The extract had minimal irritancy following vaginal application.
authors.affiliation: Laboratory of Pharmacology, Center of Pharmaceutical Chemistry, Havana, Cuba. gabino.garrido@infomed.sld.cu
authors.forename: Gabino
authors.initials: G
authors.lastname: Garrido
authors.forename: Idania
authors.initials: I
authors.lastname: Rodeiro
authors.forename: Ivones
authors.initials: I
authors.lastname: Hernández
authors.forename: Gastón
authors.initials: G
authors.lastname: García
authors.forename: Gema
authors.initials: G
authors.lastname: Pérez
authors.forename: Nelson
authors.initials: N
authors.lastname: Merino
authors.forename: Alberto
authors.initials: A
authors.lastname: Núñez-Sellés
authors.forename: René
authors.initials: R
authors.lastname: Delgado
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D031022:Mangifera / Q000737:chemistry*; D008519:Medicine, Traditional; D051379:Mice; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D023382:Toxicity Tests, Acute
chemical_list: D000975:Antioxidants; C501277:Mangifera indica extract; D010936:Plant Extracts