title: Expanding RNA silencing approaches by U1 adaptors.
abstract: Silent partner: In a recent publication, Gunderson and co-workers described an approach to recruit the abundant U1 snRNP, a splicing subparticle, to the last exon of a pre-mRNA, in a sequence-specific manner. This mediates interaction of the U1-70K protein subunit with poly(A) polymerase, thus blocking polyadenylation and inducing pre-mRNA degradation. This novel promising strategy expands the repertoire of gene-silencing concepts.
authors.affiliation: Pharmaceutical Chemistry, Philipps-Universität Marburg, Marbacher Weg 6, Marburg, Germany.
authors.forename: Arnold
authors.initials: A
authors.lastname: Grünweller
authors.forename: Roland K
authors.initials: RK
authors.lastname: Hartmann
mesh_terms: D001483:Base Sequence; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D011062:Polynucleotide Adenylyltransferase / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000378:metabolism*
chemical_list: D012322:RNA Precursors; D017412:Ribonucleoprotein, U1 Small Nuclear; D011062:Polynucleotide Adenylyltransferase