title: Psychological factors in leg ulceration: a case-control study.
abstract: BACKGROUND
  There is increasing recognition of the role that psychological status plays in the development and outcomes of chronic disease, but little understanding of its importance in chronic leg ulceration.
  
  
  OBJECTIVE
  To examine psychological health and perceived social support in patients with chronic leg ulceration.
  
  
  METHODS
  Patients with leg ulceration within a defined population were matched for age and gender (1:1) with community controls in a matched case-control study. Analysis was by conditional logistic regression and matched t-test analysis.
  
  
  RESULTS
  Ninety-five patients (60 women and 35 men; 59% aged over 75 years) were identified and matched to the same number of controls. Cases had significantly poorer health-related quality of life in all domains of the Nottingham Health Profile (all P < or = 0.001), compared with controls. Levels of depression (Hospital Anxiety and Depression Scale) were significantly greater in the patient group (mean 5.3 vs. 3.6, P < 0.001). Social support (Medical Outcomes Study Social Support Survey scale) showed significantly fewer social networks and less perceived social support in patients than controls (P = 0.008). Patients used significantly fewer coping strategies (COPE scale) than controls, particularly with regard to problem-focused coping strategies.
  
  
  CONCLUSIONS
  Patients with leg ulceration experience poor psychological health with a greater risk of depression, less perceived social support and greater social isolation. Systems of care should offer an environment that reduces social isolation and increases support to this patient group.
authors.affiliation: Centre for Research & Implementation of Clinical Practice, London, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Moffatt
authors.forename: P J
authors.initials: PJ
authors.lastname: Franks
authors.forename: D C
authors.initials: DC
authors.lastname: Doherty
authors.forename: R
authors.initials: R
authors.lastname: Smithdale
authors.forename: A
authors.initials: A
authors.lastname: Steptoe
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D003866:Depressive Disorder / Q000523:psychology*; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000523:psychology*; D008297:Male; D011788:Quality of Life / Q000523:psychology*; D012944:Social Support; D013315:Stress, Psychological / Q000523:psychology*; D011795:Surveys and Questionnaires; D016138:Walking / Q000523:psychology