A chimeric measles virus with canine distemper envelope protects ferrets from lethal distemper challenge.
CDV infects a broad range of carnivores, and over the past decades it has caused outbreaks in a variety of wild carnivore populations. Since the currently available live-attenuated vaccine is not sufficiently safe in these highly susceptible species, we produced a chimeric virus combining the replication complex of the measles Moraten vaccine strain with the envelope of a recent CDV wild type isolate. The resulting virus did not cause disease or immunosuppression in ferrets and conferred protection from challenge with a lethal wild type strain, demonstrating its potential value for wildlife conservation efforts.
Rouxel
Ronan Nicolas
RN
INRS-Institut Armand-Frappier, University of Quebec, 531, boul. des Prairies, Laval, Quebec H7V 1B7, Canada.
Svitek
Nicholas
N
von Messling
Veronika
V
D000281:Administration, Intranasal; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001831:Body Temperature; D001835:Body Weight; D004216:Distemper / Q000517:prevention & control*; D004217:Distemper Virus, Canine / Q000235:genetics / Q000276:immunology*; D005289:Ferrets; D005822:Genetic Vectors; D007074:Immunoglobulin G / Q000097:blood; D007273:Injections, Intramuscular; D007962:Leukocytes / Q000276:immunology; D008297:Male; D008459:Measles virus / Q000235:genetics*; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D014759:Viral Envelope Proteins; D014765:Viral Vaccines