title: Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer.
abstract: BACKGROUND
  The etiology of ovarian cancer is largely unknown. One hypothesis is that the inefficient removal of the blood clots and fibrin products which are deposited in the vicinity of the ovary by retrograde menstruation might be associated with an increased risk of ovarian cancer. Several single nucleotide polymorphisms within genes which comprise the fibrinolytic system have been shown to have functional effects on the rate of blood clot degradation. These were considered to be candidate genes in the present study.
  
  
  OBJECTIVE
  We studied the genotype distributions of 12 functional SNPs of four genes (tPA, uPA PAI1 and TAFI) among 775 ovarian cancer cases and 889 controls.
  
  
  RESULTS
  No significant associations were seen between any of the ten SNPs and the risk of ovarian cancer as a whole, or in any histologic subgroup.
  
  
  CONCLUSIONS
  Germline known functional variants of genes in the fibrinolytic system are not associated with risk of ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada. Bentov@lunenfeld.ca
authors.forename: Yaakov
authors.initials: Y
authors.lastname: Bentov
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Brown
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Akbari
authors.forename: Robert
authors.initials: R
authors.lastname: Royer
authors.forename: Harvey
authors.initials: H
authors.lastname: Risch
authors.forename: Barry
authors.initials: B
authors.lastname: Rosen
authors.forename: John
authors.initials: J
authors.lastname: McLaughlin
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.forename: Shiyu
authors.initials: S
authors.lastname: Zhang
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.forename: Robert F
authors.initials: RF
authors.lastname: Casper
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005342:Fibrinolysis; D005838:Genotype; D018095:Germ-Line Mutation; D006801:Humans; D007249:Inflammation; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk