Adult fulminant subacute sclerosing panencephalitis: pathological and molecular studies--a case report.
Subacute sclerosing panencephalitis is an uncommon progressive neurological disorder caused by a persistent defective measles virus, typically affecting children. We describe a case of fulminant subacute sclerosing panencephalitis in a 25-year-old male. Brain tissue biopsy showed histologic evidence of encephalitis with eosinophilic intranuclear inclusion bodies (Cowdry Type A and B), intracytoplasmic inclusion bodies, perivascular lymphoplasmacytic infiltration and gliosis. Immunohistochemical studies were positive using an anti-measles antibody. Reverse transcriptase-PCR detected measles virus RNA and phylogenetic analysis indicated a C2 genotype. The rare adult-onset form is often atypical and difficult to diagnose and should be included in the differential diagnosis of subacute "unexplained" neurological diseases and uncommon infectious disorders.
Souraud
J B
JB
Department of Pathology, HIA Sainte-Anne, Toulon, France. jsouraud@hotmail.com
Faivre
A
A
Waku-Kouomou
D
D
Gaillard
T
T
Aouad
N
N
Meaudre
E
E
Wild
F T
FT
Fouet
B
B
Soulard
R
R
D001483:Base Sequence; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013190:SSPE Virus / Q000235:genetics*; D013344:Subacute Sclerosing Panencephalitis / Q000378:metabolism / Q000473:pathology* / Q000821:virology*; D055815:Young Adult
D012367:RNA, Viral