title: Carboxyl enriched monodisperse porous Fe3O4 nanoparticles with extraordinary sustained-release property.
abstract: Carboxyl-enriched monodisperse porous Fe3O4 nanoparticles with diameters of about 85-nm have been synthesized via a simple hydrothermal method. The porous structure of the product is confirmed further by transmission electron microscopy (TEM) observation and nitrogen sorption measurement with a Brunauer-Emmett-Teller (BET) surface area about 36.61 m2/g. An IR spectrum of the sample identifies that abundant carboxylate groups are formed on the surface of the nanoparticles as well as the pore surface. Because of the confined effect of the nanochannels in the nanoparticles and carboxyl-functionalized Fe3O4 nanoparticles, and the strong interaction between ibuprofen and COO-, as-prepared porous nanoparticles show a more extraordinary sustained-release property than that of hollow silica nanoparticles in vitro. This result suggests that as-prepared porous nanoparticles can also be used for the targeted delivery of other aromatic acid drugs.
authors.affiliation: College of Chemistry and Materials Science, Anhui Key Laboratory of Functional Molecular Solids, Anhui Normal University, Wuhu 241000, China.xwliu601@yahoo.com.cn
authors.forename: Xiaowang
authors.initials: X
authors.lastname: Liu
authors.forename: Qiyan
authors.initials: Q
authors.lastname: Hu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Fang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Qiubo
authors.initials: Q
authors.lastname: Xie
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D003692:Delayed-Action Preparations; D005290:Ferric Compounds / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry / Q000494:pharmacology; D046529:Microscopy, Electron, Transmission; D008954:Models, Biological; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity
chemical_list: D002264:Carboxylic Acids; D003692:Delayed-Action Preparations; D005290:Ferric Compounds; D002245:Carbon Dioxide; C041069:carboxyl radical; C000499:ferric oxide; D007052:Ibuprofen