title: Orgasm is preserved regardless of ejaculatory dysfunction with selective alpha1A-blocker administration.
abstract: We evaluated whether ejaculatory dysfunction induced with a selective alpha1A-blocker influenced orgasm. Fifteen healthy male volunteers took silodosin or a placebo in a randomized, double-blind crossover design. We investigated the ejaculatory volume before and after administration of the agents. After each ejaculation, participants self-reported the answers to an original questionnaire, which was about discomfort on ejaculation, orgasm and satisfaction with the discomforting ejaculation. All participants on silodosin had a complete lack of seminal emission and expulsion. All participants felt orgasm in spite of a complete lack of seminal emission. Of the 15, 12 (80%) who had a somewhat uncomfortable feeling during orgasm were dissatisfied with this feeling, although 9 of the 12 reported that its degree was mild. Orgasm is preserved regardless of the loss of seminal emission with silodosin administration. Although most participants reported mild discomfort during orgasm, they were greatly dissatisfied with the loss of seminal emission.
authors.affiliation: Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan. kou@sapmed.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Masumori
authors.forename: R
authors.initials: R
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Hisasue
authors.forename: R
authors.initials: R
authors.lastname: Furuya
authors.forename: T
authors.initials: T
authors.lastname: Tsukamoto
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004542:Ejaculation / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009948:Orgasm / Q000187:drug effects*; D018340:Receptors, Adrenergic, alpha-1; D012661:Semen / Q000502:physiology; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*
chemical_list: C547713:ADRA1A protein, human; D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D007211:Indoles; D018340:Receptors, Adrenergic, alpha-1; C095285:silodosin