title: Pharmacokinetics and ex vivo pharmacodynamic antimalarial activity of dihydroartemisinin-piperaquine in patients with uncomplicated falciparum malaria in Vietnam.
abstract: Compared to healthy subjects, malaria patients show a reduction in the mean oral clearance (1.19 versus 5.87 liters/h/kg of body weight) and apparent volume of distribution (1.47 versus 8.02 liters/kg) of dihydroartemisinin in Vietnamese patients following treatment with dihydroartemisinin-piperaquine (Artekin) for uncomplicated Plasmodium falciparum. Dihydroartemisinin is responsible for most of the ex vivo antimalarial activity of dihydroartemisinin-piperaquine.
authors.affiliation: Department of Infectious Diseases, Military Hospital 175, Ho Chi Minh City, Vietnam.
authors.forename: Dao Van Hoang
authors.initials: DV
authors.lastname: Nguyen
authors.forename: Quoc Phuc
authors.initials: QP
authors.lastname: Nguyen
authors.forename: Ngoa Dang
authors.initials: ND
authors.lastname: Nguyen
authors.forename: Thuy Thi Thanh
authors.initials: TT
authors.lastname: Le
authors.forename: The Duy
authors.initials: TD
authors.lastname: Nguyen
authors.forename: Duy Ngoc
authors.initials: DN
authors.lastname: Dinh
authors.forename: Thanh Xuan
authors.initials: TX
authors.lastname: Nguyen
authors.forename: Dai
authors.initials: D
authors.lastname: Bui
authors.forename: Marina
authors.initials: M
authors.lastname: Chavchich
authors.forename: Michael D
authors.initials: MD
authors.lastname: Edstein
mesh_terms: D000293:Adolescent; D000962:Antimalarials / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D037621:Artemisinins / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011804:Quinolines / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D014744:Vietnam; D055815:Young Adult; D010879:Piperazines
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D011804:Quinolines; C039060:artenimol; C034759:piperaquine; D010879:Piperazines