title: Oxidative carbon-carbon bond formation in the synthesis of bioactive spiro beta-lactams.
abstract: New oxidative dearomatization procedures leading to spiro beta-lactams and oxindoles were developed. By a variation of the oxidative reaction conditions, the usefulness of phenolic amides, derived from 4-aminophenol, in the synthesis of structurally different types of molecules was demonstrated.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan 650091, PR China.
authors.forename: Jixuan
authors.initials: J
authors.lastname: Liang
authors.forename: Jingbo
authors.initials: J
authors.lastname: Chen
authors.forename: Fengxiang
authors.initials: F
authors.lastname: Du
authors.forename: Xianghui
authors.initials: X
authors.lastname: Zeng
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000627:Aminophenols / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011760:Pyrrolidinones / Q000138:chemical synthesis / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000627:Aminophenols; D007211:Indoles; D011760:Pyrrolidinones; D013141:Spiro Compounds; D047090:beta-Lactams; C026729:4-aminophenol