[The expression of PTEN and P16 protein in nasal inverted papilloma].
OBJECTIVE
To explore the expression of PTEN and P16 protein, and its relationship with the occurrence, development and prognosis of nasal inverted papilloma (NIP).


METHODS
The expressions of PTEN and P16 were detected in 27 cases with NIP and 10 cases with normal mucosa of sphenoid by immunohistochemistry and image analytical system, and were analyzed in NIP cases with different prognosis.


RESULTS
The positive expression PTEN and P16 protein were both significantly decreased compared with normal sinus mucosa (P<0.05). There was a significant difference of the PTEN expression between NIP with no-recurrence and that recurred (P<0.05). The expression of P16 protein decrease in different NIP groups but there was no statistic significance between them (P>0.05).


CONCLUSIONS
Decreasing or depletion of PTEN might be a sign of NIP development and unfavorable prognosis, and P16 protein is also closely related with the occurrence of NIP.
Zhao
Jiandong
J
Department of Otolaryngology, the Second Hospital, Shandong University, Jinan, 250033, China. zhaojd.jack@yahoo.com.cn
Wang
Yanjun
Y
Kong
Weijia
W
D000328:Adult; D016022:Case-Control Studies; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D018308:Papilloma, Inverted / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
D019941:Cyclin-Dependent Kinase Inhibitor p16; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human