Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis.
BACKGROUND
Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. We have investigated the possible association between a single nucleotide polymorphism of the HNMT (chromosome 2q22.1), that causes the amino acid substitution Thr105Ile (decreasing enzyme activity) and the risk for MS.


METHODS
We studied the frequency of the HNMT genotypes and allelic variants in 228 MS patients and 295 healthy controls using a PCR-RLFP method.


RESULTS
The frequencies of the HNMT genotypes and allelic variants did not differ significantly between MS patients and controls, and were unrelated with the age of onset of MS, gender, and course of MS.


CONCLUSIONS
The HNMT polymorphism is not related with the risk for MS.
García-Martín
E
E
Biochemistry-Molecular Biology Department, University of Extremadura, Badajoz, Spain.
Martínez
C
C
Benito-León
J
J
Calleja
P
P
Díaz-Sánchez
M
M
Pisa
D
D
Alonso-Navarro
H
H
Ayuso-Peralta
L
L
Torrecilla
D
D
Agúndez
J A G
JA
Jiménez-Jiménez
F J
FJ
D000328:Adult; D017668:Age of Onset; D000483:Alleles; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006637:Histamine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000235:genetics*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000235:genetics*; D020125:Mutation, Missense; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012737:Sex Factors; D013030:Spain; D044465:White People / Q000235:genetics
D006637:Histamine N-Methyltransferase