Effects of prolylendopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on experimental depressive syndrome development in rats.
Model of experimental depressive syndrome in rats induced by repeated systemic injection of proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine showed that chronic injection of prolylendopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine 30 min before pro-neurotoxin injection prevents the development of a number of depressive syndrome symptoms such as behavioral despair and biorhythmic disorders in forced swimming test, precludes the increase in anxiety-phobic level, prevents reduction of relative thymus mass. These results indicate that benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine possesses antidepressant, anxiolytic, and/antistress properties.
Khlebnikova
N N
NN
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. nanikh@yandex.ru
Krupina
N A
NA
Bogdanova
N G
NG
Zolotov
N N
NN
Kryzhanovskii
G N
GN
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage; D000818:Animals; D003863:Depression / Q000188:drug therapy*; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000085822:Prolyl Oligopeptidases; D011480:Protease Inhibitors / Q000627:therapeutic use*; D011759:Pyrrolidines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000187:drug effects*
D011480:Protease Inhibitors; D011759:Pyrrolidines; C543067:benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D008715:Methionine; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases