Computed tomography perfusion source images assessment of infarct core and penumbra in acute stroke.
OBJECTIVE
The purpose of this study was to develop a methodology on computed tomography (CT) perfusion source images for an acute ischemic stroke in predicting infarct core and penumbra.


METHODS
Computed tomography examinations, including non-contrast enhanced CT, CT perfusion and CT angiography, were performed on 24 patients with symptoms of stroke in less than 9 hours. The Alberta Stroke Program Early CT Score (ASPECTS) was analysed on arterial and venous phase CT perfusion source images and then compared with the ASPECTS on follow-up imaging for an efficacy assessment.


RESULTS
The ASPECTS on arterial phase CT perfusion source images was significantly different from venous phase CT perfusion source images (z=-2.812, p=0.005); linear regression analysis revealed that there was a statistically significant relationship between venous phase CT perfusion source images and the follow-up imaging (beta=0.715, p=0.003).


CONCLUSIONS
The limited data suggested that CT perfusion source images of both arterial and venous phases may have the potential of being used as an assessment for infarct core and penumbra in acute ischemic stroke.
Wang
Xiao-Chun
XC
Department of Neuroradiology, Capital Medical University, Beijing, China.
Gao
Pei-Yi
PY
Xue
Jing
J
Liu
Guang-Rui
GR
Ma
Li
L
Wang
Chen
C
Sui
Bin-Bin
BB
Wang
Chun-Juan
CJ
Liao
Xiao-Ling
XL
Wang
Yong-Jun
YJ
D000328:Adult; D000368:Aged; D020520:Brain Infarction / Q000209:etiology / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000379:methods*; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications; D014057:Tomography, X-Ray Computed / Q000379:methods*