Preliminary analysis of the antinociceptive activity of zerumbone.
We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive effect in all the test models used. In addition, the antinociceptive effect of 1 in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action.
Sulaiman
M R
MR
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. mrs@medic.upm.edu.my
Perimal
E K
EK
Zakaria
Z A
ZA
Mokhtar
F
F
Akhtar
M N
MN
Lajis
N H
NH
Israf
D A
DA
D015746:Abdominal Pain / Q000139:chemically induced / Q000188:drug therapy*; D019342:Acetic Acid; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D030521:Zingiberaceae / Q000737:chemistry*
D000700:Analgesics; D009292:Narcotic Antagonists; D010936:Plant Extracts; D012717:Sesquiterpenes; D009270:Naloxone; C403304:zerumbone; D019342:Acetic Acid