title: Optimization of the production medium for biosynthesis of antifungal antibiotic AK-111-81 by phosphate-deregulated mutant of Streptomyces hygroscopicus.
abstract: Experimental mathematical designs were applied for optimization of a nutrient medium for biosynthesis of the antifungal antibiotic AK-111-81 by phosphate-deregulated mutant of Streptomyces hygroscopicus 111-81. Antifungal antibiotic AK-111-81 possesses well-expressed activity against Fusarium graminearum and other phytopathogenic fungi. The level of the production of the antibiotic AK-111-81 on this medium is more than three times higher than on the initial medium. The optimized quantitative composition of the nutrient culture media is (g/l): glucose, 20; soy meal, 18; ammonium succinate, 3; CaCO(3), 1.
authors.affiliation: Institute of Microbiolgy, Bulgarian Academy of Sciences, Department of Microbial Biosynthesis and Biotechnology, Sofia, Bulgaria. teteven@excite.com
authors.forename: Victoria
authors.initials: V
authors.lastname: Gesheva
mesh_terms: D000935:Antifungal Agents / Q000096:biosynthesis*; D003470:Culture Media / Q000737:chemistry*; D009154:Mutation; D010710:Phosphates / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D010710:Phosphates