Anti-angiogenesis and anti-tumor effects of AdNT4-anginex.
Anginex is a novel artificial peptide that can inhibit angiogenesis. AdNT4-anginex was constructed by inserting the artificial anginex gene into a recombinant adenoviral vector. We demonstrated that AdNT4-anginex inhibited migration of human endothelial cells, angiogenesis and tumor growth in in vitro and in vivo studies. Tumor growth of human H22 hepatoma in mice was inhibited after AdNT4-anginex treatment for 4 weeks, and a significant decrease in tumor size was observed as compared with the control group. Overall, these studies indicate that AdNT4-anginex is an effective anti-tumor agent, and deserves more attention and research.
Dong
Dan Feng
DF
Department of Medical Oncology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
Li
En Xiao
EX
Wang
Ju Bo
JB
Wu
Yin Ying
YY
Shi
Fan
F
Guo
Jun Jun
JJ
Wu
Yuan
Y
Liu
Jun Ping
JP
Liu
Shan Xi
SX
Yang
Guang Xiao
GX
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002642:Chick Embryo; D005260:Female; D005822:Genetic Vectors; D006801:Humans; D051379:Mice; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D010455:Peptides; D011506:Proteins / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
D000970:Antineoplastic Agents; D010455:Peptides; D011506:Proteins; C111993:betapep-25 protein, synthetic