title: The diagnosis of IgE-mediated food allergy in childhood.
abstract: IgE-mediated food allergy is a common condition in childhood and a recognized public health concern. An accurate diagnosis of food allergy facilitates the avoidance of the allergen - and cross-reactive allergens - and allows for safe dietary expansion. The diagnosis of food allergy relies on a combination of rigorous history, physical examination, allergy tests [skin prick tests (SPT) and/or serum-specific IgE] and oral food challenges. Diagnostic cut-off values for SPT and specific IgE results have improved the diagnosis of food allergy and thereby reduced the need to perform oral food challenges. This clinical case series seeks to highlight a contemporary approach to the diagnosis of food allergy in children strategies.
authors.affiliation: MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK. georgedutoit@gmail.com
authors.forename: G
authors.initials: G
authors.lastname: Du Toit
authors.forename: A
authors.initials: A
authors.lastname: Santos
authors.forename: G
authors.initials: G
authors.lastname: Roberts
authors.forename: A T
authors.initials: AT
authors.lastname: Fox
authors.forename: P
authors.initials: P
authors.lastname: Smith
authors.forename: G
authors.initials: G
authors.lastname: Lack
mesh_terms: D000485:Allergens / Q000276:immunology*; D002675:Child, Preschool; D003429:Cross Reactions / Q000276:immunology; D021181:Egg Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology*; D007223:Infant; D008297:Male; D021183:Peanut Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E