Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.
At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use.
Woodward
Wendy A
WA
The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA. wwoodward@mdanderson.org
Bristow
Robert G
RG
Clarke
Michael F
MF
Coppes
Robert P
RP
Cristofanilli
Massimo
M
Duda
Dan G
DG
Fike
John R
JR
Hambardzumyan
Dolores
D
Hill
Richard P
RP
Jordan
Craig T
CT
Milas
Luka
L
Pajonk
Frank
F
Curran
Walter J
WJ
Dicker
Adam P
AP
Chen
Yuhchyau
Y
D014408:Biomarkers, Tumor / Q000032:analysis / Q000502:physiology; D035843:Biomedical Research; D015687:Cell Hypoxia; D002986:Clinical Trials as Topic; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D005434:Flow Cytometry / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000473:pathology; D033181:Information Dissemination; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009369:Neoplasms / Q000737:chemistry / Q000473:pathology / Q000628:therapy; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D018787:Radiation Oncology
D014408:Biomarkers, Tumor