title: Comparison of GnRH antagonist protocol with or without oral contraceptive pill pretreatment and GnRH agonist low-dose long protocol in low responders undergoing IVF/intracytoplasmic sperm injection.
abstract: This prospective randomized study was performed to compare the efficacy of GnRH antagonist multiple-dose protocol (MDP) with or without oral contraceptive pill (OCP) pretreatment and GnRH agonist low-dose long protocol (LP) in 82 patients undergoing IVF/intracytoplasmic sperm injection (ICSI). GnRH antagonist MDP with OCP pretreatment was at least as effective as GnRH agonist low-dose LP in low responders, and can benefit the low responders by reducing the amount of FSH and the number of days of stimulation required for follicular maturation.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. chnkim@amc.seoul.kr
authors.forename: Chung-Hoon
authors.initials: CH
authors.lastname: Kim
authors.forename: Gyun-Ho
authors.initials: GH
authors.lastname: Jeon
authors.forename: Yong-Pil
authors.initials: YP
authors.lastname: Cheon
authors.forename: Ilkyung
authors.initials: I
authors.lastname: Jeon
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Hee-Dong
authors.initials: HD
authors.lastname: Chae
authors.forename: Byung-Moon
authors.initials: BM
authors.lastname: Kang
mesh_terms: D000328:Adult; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004351:Drug Resistance / Q000187:drug effects / Q000502:physiology; D004359:Drug Therapy, Combination; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000037:antagonists & inhibitors*; D006727:Hormone Antagonists / Q000008:administration & dosage; D006801:Humans; D008297:Male; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D013607:Tablets; D016896:Treatment Outcome
chemical_list: D003276:Contraceptives, Oral; D006727:Hormone Antagonists; D013607:Tablets; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone