Fibrinogen gene polymorphism (Bbeta-148C/T) in Uygur patients with cerebral infarction.
OBJECTIVE
To explore the frequency distribution of the fibrinogen gene polymorphism (Bbeta-148C/T) and its relationship with plasma fibrinogen (Fg) level in Uygur patients with cerebral infarction in Xinjiang.


METHODS
The frequency distribution of FgBbeta-148C/T was analysed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in the Uygur cerebral infarction group (n=62) and the Uygur control group without cerebral infarction (n=64). Plasma fibrinogen levels were measured by the automatic coagulation analyser.


RESULTS
The frequency of the T allele in the cerebral infarction group was significantly higher than that of the control group (0.31 versus 0.19, p<0.05). The plasma fibrinogen level of the cerebral infarction group was also significantly higher than that of the control group (4.19 +/- 1.29 g/l versus 3.08 +/- 0.56 g/l, p<0.01). The plasma fibrinogen levels in both CT and TT genotype subgroups in patients with cerebral infarction were higher than those in the CC genotype subgroups (p<0.01). They were also higher than those in the CT and TT genotype subgroups within the control group (p<0.05).


CONCLUSIONS
The fibrinogen gene polymorphism (Bbeta-148C/T) affects plasma fibrinogen concentration. T allele, alone or cooperating with other risk factors, increases the plasma fibrinogen level. Thus, the fibrinogen gene polymorphism (Bbeta-148C/T) may be related with cerebral infarction. T allele may be a risk factor for cerebral infarction by increasing the plasma fibrinogen level. The above conclusion is in accordance with similar studies on the Han nationality in China.
Guo
Xuebing
X
Department of Neurology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Zhang
Danni
D
Zhang
Xiaoning
X
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000235:genetics* / Q000378:metabolism; D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis; D005006:Ethnicity; D005260:Female; D005340:Fibrinogen / Q000235:genetics* / Q000378:metabolism; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*
C115499:BBeta fibrinogen; D005340:Fibrinogen