title: The relationship between adipokines, osteocalcin and bone quality in chronic kidney disease.
abstract: OBJECTIVE
  Osteocalcin, a small peptide secreted by osteoblasts, has been recently described as a circulating hormone involved in the regulation of energy metabolism. In addition, experimental data suggest a regulation of adipocytes by bone, with a stimulation of adiponectin synthesis by osteocalcin and an inverse relationship between serum adiponectin level and bone mineral density (BMD). However, this relationship has not been explored during chronic kidney disease (CKD).
  
  
  METHODS
  Osteocalcin, adiponectin and leptin were prospectively measured in a cohort of 61 CKD patients. A new non-invasive 3D bone imaging technique was performed (high-resolution peripheral quantitative computed tomography, HR-pQCT), measuring volumetric BMD (vBMD) and microarchitecture parameters at the distal tibia.
  
  
  RESULTS
  Patients' mean age was 67.2 +/- 13.9 years and mean GFR 33 +/- 12 mL/min/1.73 m(2). We found a positive association between serum osteocalcin and adiponectin (r = 0.29, P = 0.021). Univariate analysis showed inverse correlations between serum adiponectin and total vBMD (r = -0.33, P = 0.01), cortical thickness (r = -0.34, P = 0.008) and trabecular vBMD (r = -0.27, P = 0.04). These associations remained significant in multivariate analysis between serum adiponectin and total vBMD, cortical vBMD and cortical thickness.
  
  
  CONCLUSIONS
  We report for the first time an inverse relationship between bone density and adiponectin, as well as a positive association between osteocalcin and adiponectin in CKD II-IV patients.
authors.affiliation: Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, Bron, France.
authors.forename: Justine
authors.initials: J
authors.lastname: Bacchetta
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Boutroy
authors.forename: Fitsum
authors.initials: F
authors.lastname: Guebre-Egziabher
authors.forename: Laurent
authors.initials: L
authors.lastname: Juillard
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Drai
authors.forename: Solenne
authors.initials: S
authors.lastname: Pelletier
authors.forename: Michel
authors.initials: M
authors.lastname: Richard
authors.forename: Anne
authors.initials: A
authors.lastname: Charrié
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Carlier
authors.forename: Roland
authors.initials: R
authors.lastname: Chapurlat
authors.forename: Maurice
authors.initials: M
authors.lastname: Laville
authors.forename: Denis
authors.initials: D
authors.lastname: Fouque
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015519:Bone Density; D002908:Chronic Disease; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000378:metabolism; D020738:Leptin / Q000097:blood*; D015675:Osteocalcin / Q000097:blood*; D011446:Prospective Studies
chemical_list: D052242:Adiponectin; D020738:Leptin; D015675:Osteocalcin