Sotalol as adjunctive therapy to implantable cardioverter-defibrillators in heart failure patients.
The number of heart failure patients with implantable cardioverter-defibrillators is rising. Common issues encountered in this population are high defibrillation thresholds and inappropriate shocks. In order to resolve these problems, the addition of a class III antiarrhythmic such as sotalol is often considered. Given the emerging issue of polypharmacy and medication compliance in the heart failure population, the question of the efficacy of sotalol in reducing inappropriate shocks, defibrillation thresholds, and its ability to replace conventional beta-blockers is often raised. Current literature review suggests that sotalol is a useful adjunct to the contemporary heart failure regimen. It has the ability to reduce inappropriate shocks and defibrillation thresholds, but appears not to fully reproduce the pleiotropic beneficial effects of the beta-blockers more commonly employed for their mortality/remodeling benefits in heart failure patients.
Chaki
Amber L
AL
Shands Jacksonville Department of Pharmacy, College of Pharmacy, University of Florida, 655 West 8th Street, Jacksonville, FL, USA. amber.chaki@jax.ufl.edu
Caines
Amitra E
AE
Miller
Alan B
AB
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D017147:Defibrillators, Implantable; D006333:Heart Failure / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D013015:Sotalol / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D013015:Sotalol