Circadian misalignment in major depressive disorder.
It has been hypothesized that the circadian pacemaker plays a role in major depressive disorder (MDD). We sought to determine if misalignment between the timing of sleep and the pacemaker correlated with symptom severity in MDD. Depression severity correlated with circadian misalignment: the more delayed, the more severe the symptoms.
Emens
Jonathan
J
Department of Psychiatry, Oregon Health & Science University, Portland, OR 97239, USA. emensj@ohsu.edu
Lewy
Alfred
A
Kinzie
John Mark
JM
Arntz
Diana
D
Rough
Jennifer
J
D000328:Adult; D021081:Chronobiology Disorders / Q000209:etiology*; D003865:Major Depressive Disorder / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D055815:Young Adult