Histidine analogues of oxytocin and vasopressin as efficient ligands for Zn2+ ions--potentiometric and NMR studies.
We have characterized the interaction between the Zn(2+) ions and the histidine analogues of oxytocin and arginine-vasopressin. Potentiometric methods were used for the determination of the stoichiometry of the complexes formed and the calculation of their stability constants. The NMR measurements revealed detailed structures of the complexes and confirmed the binding mode at physiological pH.
Brasuń
Justyna
J
Department of Inorganic Chemistry, Wrocław Medical University, Wrocław, Poland. jbrasun@chnorg.am.wroc.pl
Cebrat
Marek
M
Jaremko
Mariusz
M
Jaremko
Łukasz
Ł
Gładysz
Olimpa
O
Zhukov
Igor
I
D001127:Arginine Vasopressin / Q000031:analogs & derivatives*; D002413:Cations, Divalent / Q000737:chemistry; D006639:Histidine / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D019906:Nuclear Magnetic Resonance, Biomolecular; D010121:Oxytocin / Q000031:analogs & derivatives*; D011199:Potentiometry; D015032:Zinc / Q000737:chemistry*
D002413:Cations, Divalent; D008024:Ligands; D001127:Arginine Vasopressin; D006639:Histidine; D010121:Oxytocin; D015032:Zinc