title: Longitudinal changes in plasma Transforming growth factor beta-1 and post-burn scarring in children.
abstract: Transforming growth factor beta1, a multifunctional growth factor, plays a pivotal role in wound healing and has been shown to accelerate impaired wound healing. However, high systemic levels of Transforming growth factor beta1 have generally been associated with fibrotic disease processes such as myelofibrosis and pulmonary fibrosis. Hypertrophic scarring occurring during childhood interferes with growth, impairs the function and causes immense psychological and aesthetic problems. Burns is the leading cause of hypertrophic scarring. We studied the longitudinal relationship between plasma Transforming growth factor beta-1 and post-burn wound healing and scarring in children. We discovered that the plasma levels of Transforming growth factor beta-1 rapidly increased to significantly higher levels in the first two weeks post-injury and fell thereafter, in patients who healed with good quality scars post-burn. By contrast, the increase in plasma TGFbeta1 levels in the early stages after-burn, was noticeably absent in patients who developed hypertrophic scarring. We propose that this change in the systemic levels of TGFbeta1 early after the burn may be used as an indicator of patients at risk of developing hypertrophic burn scars. This group of patients could then be targeted for early pharmacological/physical interventions to reduce/prevent scar-related morbidity in burn survivors.
authors.affiliation: Birmingham Childrens' Hospital, Birmingham, United Kingdom.
authors.forename: Patricia
authors.initials: P
authors.lastname: Rorison
authors.forename: Alison
authors.initials: A
authors.lastname: Thomlinson
authors.forename: Zahid
authors.initials: Z
authors.lastname: Hassan
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Roberts
authors.forename: Mark W J
authors.initials: MW
authors.lastname: Ferguson
authors.forename: Mamta
authors.initials: M
authors.lastname: Shah
mesh_terms: D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000097:blood* / Q000150:complications / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D017439:Cicatrix, Hypertrophic / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D013997:Time Factors; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D014945:Wound Healing / Q000502:physiology
chemical_list: D015415:Biomarkers; D053773:Transforming Growth Factor beta1