title: Understanding the link between pneumococcal serotypes and invasive disease.
abstract: To determine the relationship between serotypes and the burden of pneumococcal disease in Latin American children, population- and laboratory-based surveillance data for the region were evaluated. Streptococcus pneumoniae continues to be an important bacterial pathogen causing infections in children. A seven-valent pneumococcal conjugate vaccine (PCV7) has been documented to be extremely effective in the prevention of invasive and non-invasive S. pneumoniae infections due to vaccine serotypes. However, due to evolving epidemiology, there is a need to enhance S. pneumoniae serotype coverage in future generation vaccines, complemented by ongoing surveillance of pneumococcal serotypes following vaccine introduction.
authors.affiliation: Instituto de Atención Pediátrica, Universidad de Ciencias Médicas, P.O. Box 607-1150, San Jose, Costa Rica.
authors.forename: Carolina
authors.initials: C
authors.lastname: Soley
authors.forename: Adriano
authors.initials: A
authors.lastname: Arguedas
mesh_terms: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D011159:Population Surveillance; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification*; D018074:Vaccines, Conjugate / Q000008:administration & dosage*
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate