Recurrent malignant peripheral nerve sheath tumour in a patient with neurofibromatosis Type 1: a case report.
Malignant peripheral nerve sheath tumour (MPNST) is a rare, albeit well-described, complication of neurofibromatosis. We report a 58-year-old patient with known neurofibromatosis Type 1 (NF-1) who presented with an aggressive recurrent malignant peripheral nerve sheath tumour and spinal cord compression 5 weeks after undergoing tumour excision with thoracic (T)6-7 laminectomy. The case and literature review are instructive to those following NF-1 patients with regards to screening for, and management of, malignant conversion of plexiform neurofibroma.
Dimou
J
J
Department of Neurosurgery, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia. jdimou13@hotmail.com
Jithoo
R
R
Pitcher
M
M
White
G
G
D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018317:Nerve Sheath Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D016518:Neurofibromatosis 2 / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013117:Spinal Cord Compression / Q000209:etiology; D013125:Spinal Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013131:Spine / Q000473:pathology; D014057:Tomography, X-Ray Computed