[Updated dedifferentiation and pluripotency of spermatogonial stem cells].
Spermatogonial stem cells (SSCs) are the postnatal mitotic male germ cells that undergo self-renewing and differentiate into haploid sperm through spermatogenesis throughout life time. However, some recent interesting studies indicate that pluripotent cells can be derived from SSCs in culture. Thus, it seems that SSCs are a great resource of pluripotent cells for regenerative medicine, especially to meet the demand of immuno-rejection free pluripotent cells derived from patients themselves. This article aims to introduce the current understanding and advantages of the pluripotent SSCs in regenerative medicine.
Feng
Li-Xin
LX
Department of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China. fenglx66@yahoo.com
Chen
Xiang-Feng
XF
D000818:Animals; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D008297:Male; D039904:Pluripotent Stem Cells / Q000166:cytology*; D013091:Spermatogenesis; D013093:Spermatogonia / Q000166:cytology*