Myelopeptide-5 abolishes virus-induced immunosuppression by restoring T cell functions.
Myelopeptide-5 (MP-5; synthetic analog of endogenous low-molecular-weight peptide Val-Val-Tyr-Pro-Asp) neutralized the immunosuppressive effects of antiviral vaccines (influenza, measles, and measles/parotitis) and stimulated their immunogenicity by restoring functional activity of T cells, suppressed by the viruses. Specific binding of MP-5 to CD4(+) lymphocyte (its target cell) was studied using [(3)H]MP-5 (dissociation constant 2.03 x 10(-7) M).
Belyovskaya
R G
RG
The Russian Academy of Sciences, Moscow, Russia. stas@ibch.ru
Kalyuzhnaya
M V
MV
Shevchenko
V P
VP
Kirilina
E A
EA
D000818:Animals; D006168:Guinea Pigs; D007108:Immune Tolerance / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014765:Viral Vaccines / Q000494:pharmacology*
D009842:Oligopeptides; D014765:Viral Vaccines; C502955:valyl-valyl-tyrosyl-prolyl-aspartic acid