Efficient three-component one-pot synthesis of fully substituted pyridin-2(1H)-ones via tandem Knoevenagel condensation-ring-opening of cyclopropane-intramolecular cyclization.
An efficient synthesis of fully substituted pyridin-2(1H)-ones was developed via three-component one-pot reactions of readily available 1-acetyl-1-carbamoyl cyclopropanes, malononitrile and cyclic secondary amines.
Liang
Fushun
F
Department of Chemistry, Northeast Normal University, Changchun 130024, China. liangfs112@nenu.edu.cn.
Cheng
Xin
X
Liu
Jing
J
Liu
Qun
Q