Structure and activities of a steroidal saponin from Chlorophytum nimonii (Grah) Dalz.
A new steroidal saponin, chloragin (1), was isolated and characterised from the aerial part of Chlorophytum nimonii. The structure of chloragin (1) was established as tigogenin-3-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranosyl-(1 --> 3)-beta-D-xylopyranosyl-(1 --> 4)-beta-D-glucopyranosyl-(1 --> 4)-beta-D-xyloopyranoside on the basis of detailed chemical and spectral evidence. The saponin showed potent antihyperglycaemic and antidyslipidaemic activities in albino rats.
Lakshmi
Vijai
V
Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow-226001, India. vijlakshmius@yahoo.com
Kumar
Rajesh
R
Pandey
Kartikey
K
Joshi
Bhawani Shanker
BS
Roy
Raja
R
Madhusudanan
Kunnath Padamnabham
KP
Tiwari
Priti
P
Srivastava
Arvind Kumar
AK
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D000460:Chlorophyta / Q000737:chemistry*; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D050171:Dyslipidemias / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D012503:Saponins; D013256:Steroids