Effects of plant water-soluble polysaccharides on the production of immunoglobulins E and G1 by lymphocytes of mice sensitized with ovalbumin.
Were studied the effects of water-soluble plant polysaccharides isolated from pharmacopoeic raw material on anaphylactic shock and production of IgE and IgG1 by lymphocytes from mice immunized with ovalbumin. Course treatment with polysaccharides from coltsfoot, sweet flag, clover, Artemisia, marigold, and elecampane reduced animal mortality after induction of anaphylactic shock. In addition, injection of these substances reduced serum concentrations of IgE and IgG1. These substances can be regarded as promising agents for the treatment of IgE-dependent diseases (atopic dermatitis, asthma, atopic rhinitis, urticaria, food allergies, etc.).
Danilets
M G
MG
Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Russia.
Belska
N V
NV
Bel'sky
Y P
YP
Uchasova
E G
EG
Trophimova
E S
ES
Ligatcheva
A A
AA
Guriev
A M
AM
Belousov
M V
MV
Ahmedganov
R R
RR
Usubov
M S
MS
Agaphonov
V I
VI
D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007073:Immunoglobulin E / Q000378:metabolism*; D007074:Immunoglobulin G / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D014867:Water / Q000737:chemistry
D007074:Immunoglobulin G; D011134:Polysaccharides; D014867:Water; D007073:Immunoglobulin E; D010047:Ovalbumin