Perinatal hypoxic and ischemic damage to the central nervous system causes changes in the expression of connexin 43 and CD38 and ADP-ribosyl cyclase activity in brain cells.
The expression of connexin 43 and CD38 and ADP ribosyl cyclase activity in brain cells were studied in rats with experimental hypoxic and ischemic damage to the CNS. Changes in the expression and activity of the enzyme were detected over the course of ischemic injury indicating a possible contribution of NAD(+)-converting activity and NAD(+)-transporting processes to the pathogenesis of acute cerebral ischemic injury.
Salmina
A B
AB
Department of Biochemistry with Courses of Medical, Pharmaceutical, and Toxicological Chemistry, Krasnoyarsk State Medical Agency, Federal Agency for Public Health and Social Development, Russia. allasalmina@mail.ru
Malinovskaya
N A
NA
Okuneva
O S
OS
Taranushenko
T E
TE
Fursov
A A
AA
Mikhutkina
S V
SV
Morgun
A V
AV
Prokopenko
S V
SV
Zykova
L D
LD
D036541:ADP-ribosyl Cyclase / Q000378:metabolism*; D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000503:physiopathology*; D002490:Central Nervous System / Q000378:metabolism* / Q000473:pathology; D018031:Connexin 43 / Q000378:metabolism*; D005786:Gene Expression Regulation; D015971:Gene Expression Regulation, Enzymologic; D000860:Hypoxia / Q000503:physiopathology*; D007150:Immunohistochemistry; D051381:Rats
D018031:Connexin 43; D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1