title: Intracranial hemodynamic changes during adult moyamoya disease progression.
abstract: OBJECTIVE
  This study evaluated the changes in blood flow velocity in the anterior and posterior intracranial circulations according to the progression of moyamoya disease in adult patients.
  
  
  METHODS
  We evaluated Suzuki's angiographic stage and mean blood flow velocity (MBFV) changes in intracranial vessels from both sides in 19 adult moyamoya patients. We then analyzed the linearity of MBFV changes from early to late moyamoya stages in each intracranial vessel using piecewise linear regression models.
  
  
  RESULTS
  The MBFV in the middle cerebral artery, terminal internal carotid artery, and anterior cerebral artery increased non linearly until stage III, and then decreased progressively up to stage VI. The ophthalmic artery also showed nonlinear velocity changes, with an increase in MBFV up to stage IV, followed by a decrease in MBFV up to stage VI. The MBFV of the basilar artery increased linearly from a normal velocity at an early moyamoya stage to a stenotic velocity at a late stage. There was no statistically significant regression model for the relationship between the MBFV in the posterior cerebral artery and moyamoya stage.
  
  
  CONCLUSIONS
  The nonlinear and/or linear MBFV changes associated with variable intracranial vessels might be useful in initial and follow-up evaluations of different stages of moyamoya disease.
authors.affiliation: Department of Neurology, Hospital and College of Medicine, Chungnam National University, Daejeon, Korea.
authors.forename: Hyun-Jeong
authors.initials: HJ
authors.lastname: Kwag
authors.forename: Dong-Wook
authors.initials: DW
authors.lastname: Jeong
authors.forename: Suk Hoon
authors.initials: SH
authors.lastname: Lee
authors.forename: Dae Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Jei
authors.initials: J
authors.lastname: Kim