Preconditioning with high mobility group box 1 protein protects against myocardial ischemia-reperfusion injury.
OBJECTIVE
To investigate whether preconditioning with high mobility group box 1 protein (HMGB1) could reduce myocardial ischemia-reperfusion (I/R) injury.


RESULTS
Infarct size, lactate dehydrogenase (LDH), creatine kinase (CK), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were assessed. HMGB1 preconditioning reduced significantly the infarct size induced by I/R. The LDH, CK, TNF-α and IL-6 levels were significantly decreased by HMGB1 preconditioning compared to those in the I/R group.


CONCLUSIONS
The present study suggested that preconditioning with HMGB1 could induce HMGB1 tolerance and protect against myocardial I/R injury.
Hu
Xiaorong
X
Jiang
Hong
H
Cui
Bo
B
Xu
Changwu
C
Lu
Zhibing
Z
He
Bo
B
D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D024243:HMGB1 Protein / Q000008:administration & dosage*; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D002316:Cardiotonic Agents; D024243:HMGB1 Protein