Monoamines and sexual function in rats bred for increased catatonic reactivity.
Body weight, ovary and uterus weight, the nature of estral cycles, and hypothalamus dopamine and noradrenaline levels and plasma testosterone levels were studied in female GC rats, bred for increased catatonic reactivity, at different stages of the estral cycle (estrus, proestrus). The outbred Wistar strain served as controls. On the background of decreased body weight, GC females showed impairments to the morphological cyclical changes in the ovaries and uterus, with a reduction in ovary weight in diestrus (p < 0.01) and a smaller estrogen-dependent increase in uterus weight in estrus as compared with Wistar females. On the background of decreases in dopamine and noradrenaline contents in the hypothalamus, GC rats showed higher levels of these monoamines in estrus and lower levels in diestrus. Plasma testosterone levels in female GC rats were higher in diestrus than in estrus and in Wistar rats.
Klochkov
D V
DV
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Medical Sciences, 10 Lavrent'ev Prospekt, 630090, Novosibirsk, Russia. icg-adm@bionet.nsc.ru
Alekhina
T A
TA
Kuznetsova
E G
EG
Barykina
N N
NN
D000818:Animals; D001835:Body Weight; D002389:Catatonia / Q000235:genetics*; D004298:Dopamine / Q000378:metabolism; D030762:Estrous Cycle; D005260:Female; D007031:Hypothalamus / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D009929:Organ Size; D010053:Ovary / Q000033:anatomy & histology; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000097:blood*; D014599:Uterus / Q000033:anatomy & histology
D013739:Testosterone; D004298:Dopamine; D009638:Norepinephrine