The plastic phenomenon underlying the associative processes in the addictive properties of diazepam and other psychoactive drugs.
Benzodiazepines are commonly prescribed for the therapy of disorders such as anxiety and sleep disturbance, but develop dependence in many patients. In this review we discuss the impact of different brain areas that modulate the reward system in the development of tolerance and dependence to benzodiazepine and the associative processes underlying those fenomena.
Ramirez
O A
OA
Instituto de Farmacología Experimental Córdoba (IFEC), CONICET, Dpto. Farmacología, Facultad de Ciencias Químicas, UNC, Córdoba, Argentina. oramirez@fcq.unc.edu.ar
Perez
M F
MF
D000818:Animals; D016739:Behavior, Addictive / Q000139:chemically induced*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D004361:Drug Tolerance; D006801:Humans; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D019966:Substance-Related Disorders / Q000209:etiology
D011619:Psychotropic Drugs; D003975:Diazepam