beta-Fibrinogen Gene -455 G/A Polymorphism in Korean Ischemic Stroke Patients.
OBJECTIVE
We investigated the relationship between the beta-fibrinogen gene (FGB) -455 G/A polymorphism and plasma fibrinogen levels in Korean ischemic stroke patients. We also determined whether the frequency of the -455 G/A polymorphism differed between two subtypes of noncardioembolic stroke: large-artery atherosclerosis (LAA) and small-vessel occlusion (SVO).


METHODS
A total of 267 patients with noncardioembolic stroke were enrolled. Plasma fibrinogen and other risk factors for stroke were evaluated. FGB -455 G/A genotypes were determined by polymerase chain reaction with restrictive enzyme Hae III and automatic DNA sequencing.


RESULTS
The FGB -455 G/A polymorphism was significantly associated with an elevated plasma fibrinogen level (p<0.001). The frequency of the A allele in Korean stroke patients was 16.7%. However, the frequency of the -455 G/A polymorphism did not differ between LAA and SVO.


CONCLUSIONS
The plasma fibrinogen level might be affected by the -455 G/A polymorphism in noncardioembolic stroke patients. However, the LAA and SVO subtypes of ischemic stroke were not affected by the -455 G/A polymorphism.
Lee
Seung-Han
SH
Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.
Kim
Myeong-Kyu
MK
Park
Man-Seok
MS
Choi
Seong-Min
SM
Kim
Joon-Tae
JT
Kim
Byeong-Chae
BC
Cho
Ki-Hyun
KH