Challenges, current status and future perspectives of proteomics in improving understanding, diagnosis and treatment of vascular disease.
Technical advances have seen the rapid adoption of genomics and multiplex genetic polymorphism identification to research on vascular diseases. The utilization of proteomics for the study of vascular diseases has been limited by comparison. In this review we outline currently available proteomics techniques, the challenges to using these approaches and modifications which may improve the utilization of proteomics in the study of vascular diseases.
Moxon
J V
JV
Vascular Biology Unit, School of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia.
Padula
M P
MP
Herbert
B R
BR
Golledge
J
J
D015415:Biomarkers / Q000032:analysis; D015180:Electrophoresis, Gel, Two-Dimensional / Q000639:trends; D004591:Electrophoresis, Polyacrylamide Gel / Q000639:trends; D006801:Humans; D013058:Mass Spectrometry / Q000639:trends; D011237:Predictive Value of Tests; D040081:Protein Array Analysis / Q000639:trends; D011506:Proteins / Q000032:analysis*; D040901:Proteomics / Q000639:trends*; D015203:Reproducibility of Results; D014652:Vascular Diseases / Q000175:diagnosis* / Q000628:therapy*
D015415:Biomarkers; D011506:Proteins