Arsenic-induced oxidative cerebral disorders: protection by taurine.
The present study was conducted to investigate whether the conditionally essential amino acid, taurine, could play any protective role against the potent neurotoxin arsenic (As)-induced oxidative impairment in the rat brain. Administration in the form of NaAsO(2) (at a dose of 10 mg/kg body weight for 2 days, orally), As increased the intracellular accumulation of metallic As, reactive oxygen species, and super oxide radicals. The toxin also augmented the extent of lipid peroxidation, protein carbonylation, and the levels of glutathione disulphide. Activities of the antioxidant enzymes, membrane-bound enzymes, acetylcholinesterase, and the levels of reduced glutathione, as well as total thiols, have been significantly decreased due to As exposure. Oral administration of taurine (at a dose of 100 mg/kg/body weight for 5 days) was found to be very effective in the prevention of As-induced oxidative impairment in the brain tissue of the experimental rats. To validate the experimental results, a well-known water-soluble antioxidant, vitamin C, was used as the positive control in the study. Combining all, results suggest that taurine plays a beneficial role against As-induced cerebral oxidative stress.
Das
Joydeep
J
Department of Chemistry, Bose Institute, Calcutta, West Bengal, India.
Ghosh
Jyotirmoy
J
Manna
Prasenjit
P
Sinha
Mahua
M
Sil
Parames C
PC
D000110:Acetylcholinesterase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000601:Amino Acids, Essential; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001151:Arsenic / Q000633:toxicity*; D020261:Arsenic Poisoning / Q000188:drug therapy*; D001205:Ascorbic Acid / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000627:therapeutic use; D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D016877:Oxidants / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013654:Taurine / Q000627:therapeutic use*
D000601:Amino Acids, Essential; D000975:Antioxidants; D016166:Free Radical Scavengers; D016877:Oxidants; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D013654:Taurine; D002374:Catalase; D005982:Glutathione Transferase; D000110:Acetylcholinesterase; D000251:Adenosine Triphosphatases; D005978:Glutathione; D001151:Arsenic; D001205:Ascorbic Acid