Cytotoxic activity of platinum(II) and palladium(II) complexes of N-3-pyridinylmethanesulfonamide: the influence of electroporation.
The series of complexes: cis-[Pd(PMSA)2X2], cis-[Pt(PMSA)2X2], trans-[Pt(PMSA)2I2] and [Pt(PMSA)4]Cl2 (PMSA = N-3-pyridinylmethanesulfonamide; X = Cl, Br, I), previously synthesized and characterized by us, as well as the free ligand PMSA, were tested for their cytotoxic activity without electroporation -- against murine leukemia F4N and human SKW-3 and MDA-MB-231 tumour cell lines -- and with electroporation -- against the latter two cell lines. The majority of the complexes exhibited cytotoxic effects (IC50 < 100 micromol/l) under the conditions of electroporation. Both cis- and trans-[Pt(PMSA)2I2] had pronounced cytotoxic effects (29-61 micromol/l against MDA-MB-231 cells).
Dodoff
Nicolay I
NI
Institute of Molecular Biology "Acad. R. Tsanev", Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 21, 1113 Sofia, Bulgaria. dodoff@obzor.bio21.bas.bg
Iordanov
Iordan
I
Tsoneva
Iana
I
Grancharov
Konstantin
K
Detcheva
Roumyana
R
Pajpanova
Tamara
T
Berger
Martin R
MR
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D018274:Electroporation / Q000379:methods; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute; D015458:Leukemia, T-Cell; D051379:Mice; D008958:Models, Molecular; D010165:Palladium / Q000633:toxicity*; D017671:Platinum Compounds / Q000633:toxicity*; D011759:Pyrrolidines / Q000633:toxicity; D013449:Sulfonamides / Q000633:toxicity*
D000970:Antineoplastic Agents; D017671:Platinum Compounds; D011759:Pyrrolidines; D013449:Sulfonamides; C036871:methanesulfonamide; D010165:Palladium; C043250:pyrrolidin-3-yl-methanesulfonic acid