A novel 1-indanone isolated from Uvaria afzelii roots.
Bioactivity-guided fractionations of chloromethylenic extract of the roots of U. afzelii (Annonaceae), using Leishmania donovani and Trypanosoma brucei brucei bioassay, resulted in the isolation of the two known compounds, emorydone (1) and demethoxymatteucinol (2), previously isolated from the stems, which were characterised from this source. In addition, the novel 1-indanone, afzeliindanone (3), was also isolated. The structure determination of afzeliindanone (3) was elucidated on the basis of spectral data as 4-[4-hydroxy-3-methoxyphenyl]-indan-1-one. This compound is the first 1-indanone derivative isolated from plants.
Okpekon
T
T
Laboratoire de Chimie Analytique, UFR des Sciences Pharmaceutiques et Biologiques, 22 BP 714Abidjan 22, République de Côte d'Ivoire.
Millot
M
M
Champy
P
P
Gleye
C
C
Yolou
S
S
Bories
C
C
Loiseau
P
P
Laurens
A
A
Hocquemiller
R
R
D007189:Indans / Q000737:chemistry* / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D031046:Uvaria / Q000737:chemistry*
D007189:Indans; D010936:Plant Extracts; C013352:indacrinone