title: Pioglitazone might prevent the progression of slowly progressive type 1 diabetes.
abstract: Although recent studies recommended that insulin should be administered to patients with slowly progressive type 1 diabetes, even those with non-insulin dependent status, patients prefer oral hypoglycemic agents to insulin injections. We report a slowly progressive type 1 diabetic patient whose insulin production was preserved for 4 years (SigmaC-peptide from 29.48 ng/mL to 24.58 ng/mL) using pioglitazone despite a high titer of anti-GAD antibody (GADA; 120.7 U/mL). This case suggests that pioglitazone might prevent or delay the loss of insulin secretion and insulin dependency in slowly progressive type 1 diabetic patients.
authors.affiliation: Diabetes Center, Kitasato Institute Hospital, Tokyo.
authors.forename: Yoshinaga
authors.initials: Y
authors.lastname: Kawano
authors.forename: Junichiro
authors.initials: J
authors.lastname: Irie
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakatani
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamada
mesh_terms: D000284:Administration, Oral; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D018450:Disease Progression; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D000077205:Pioglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D045162:Thiazolidinediones; D000077205:Pioglitazone