RNA interference in cancer: targeting the anti-apoptotic protein c-FLIP for drug discovery.
The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance of cancers to chemotherapeutic drugs. Resistance is associated with defects in the apoptotic signaling pathways. In this article, we examine using RNAi to target the anti-apoptotic protein cellular FLICE-like inhibitory protein (c-FLIP) for drug development.
Day
Travis W
TW
Department of Pharmacology and Toxicology, Indiana University Simon Cancer Center, Indianapolis, IN 46202, USA.
Safa
Ahmad R
AR
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000235:genetics* / Q000378:metabolism*; D055808:Drug Discovery; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D034622:RNA Interference; D015398:Signal Transduction
D053446:CASP8 and FADD-Like Apoptosis Regulating Protein