[B-cell lymphoma/leukemia-2 and benign prostatic hyperplasia].
The B-cell lymphoma/leukemia-2 (Bcl-2) gene is an important member of the Bcl-2 family, a type of protein that plays an important role in the process of cell apoptosis. Bcl-2 does not change the rate of cell proliferation, but prolongs the life and increases the number of cells by counteracting a series of apoptosis. In the recent years, more and more evidence has shown a close correlation of the Bcl-2 gene with the development and progression of benign prostatic hyperplasia (BPH), a disease whose mechanism is not yet fully understood but is drawing more and more attention towards the role of cell apoptosis.
Zhang
Min-Dao
MD
Graduate of Grade 2006, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China. zhangmindao1981@163.com
Zhao
Yong-Ning
YN
An
Li-Wen
LW
D000818:Animals; D017209:Apoptosis; D006801:Humans; D008297:Male; D051379:Mice; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D051381:Rats
D019253:Proto-Oncogene Proteins c-bcl-2