title: Cytotoxic triterpenoids from the stems of Microtropis japonica.
abstract: Bioassay-guided fractionation of a methanol extract obtained from stems of Microtropis japonica led to the isolation of six new ursane-type triterpenoids (1-6) and a new 2,3-seco-oleanane-type triterpenoid (7), together with seven known compounds. The structures of the new compounds were elucidated using spectroscopic data analysis. Among the known compounds isolated, the main component, 8 (ursolic acid), was active for HL60 cells, and its effects on histone hyperacetylation and the inhibition of histone deacetylase (HDAC) activity were investigated.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
authors.forename: I-Hsiao
authors.initials: IH
authors.lastname: Chen
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.forename: Ying-Chi
authors.initials: YC
authors.lastname: Du
authors.forename: Ming-Hong
authors.initials: MH
authors.lastname: Yen
authors.forename: Chin-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Yung-Husan
authors.initials: YH
authors.lastname: Chen
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Hung
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Chen
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D013624:Taiwan; D014315:Triterpenes / Q000494:pharmacology*; D000097245:Ursolic Acid
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D056572:Histone Deacetylase Inhibitors; D009828:Oleanolic Acid; D014315:Triterpenes; D000097245:Ursolic Acid