A flexible radical-based approach to TMS-substituted propargyl alcohols and to 2,3-allenols.
The radical reaction of TMS-substituted xanthates with 2,2-dichlorovinyl ethyl sulfone afforded TMS-substituted homodichlorovinyl compounds that can be transformed into TMS-substituted propargyl alcohols. Various 2,3-allenols were efficiently prepared from the reaction of these TMS-substituted propargyl alcohols with TBAF.
Li
Zhi
Z
Laboratoire de Synthèse Organique, UMR 7652 CNRS-Ecole Polytechnique, Route de Saclay, 91128 Palaiseau Cedex, France.
Zard
Samir Z
SZ