title: Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization.
abstract: BACKGROUND
  The prevalence of coronary artery disease (CAD) is increasing in young adults. Risk factor profiling will help to prevent heart attacks in young patients. This study aimed to analyze the risk factor profile and predictors of major cardiovascular events (MACE) in young CAD patients.
  
  
  RESULTS
  From the Coronary REvascularization Demonstrating Outcome study in the Kyoto (CREDO-Kyoto) registry of Japanese patients undergoing their first coronary revascularization, 6,320 patients with complete data for all variables for statistical analyses were divided into younger (< or =55 years; n=898; 14.3%) and older (>55 years; n=5,422; 85.7%) patients. The risk factors that were more prevalent in the younger patients than in the older patients included: male sex, body mass index of >25 kg/m(2), current smoker, family history of CAD, dyslipidemia and metabolic syndrome-like risk factor accumulation. Multivariate analyses revealed that chronic kidney disease (CKD) was the only significant predictor of MACE, the composite of cardiovascular death, myocardial infarction and cerebrovascular accident, in the younger patients. Importance of CKD as a prognostic factor was consistently shown by a multivariate analysis in the older patients.
  
  
  CONCLUSIONS
  Accumulation of multiple risk factors is prevalent and CKD is associated with MACE in young Japanese CAD patients.
authors.affiliation: Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan. furukawa@kcgh.gr.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Furukawa
authors.forename: Natsuhiko
authors.initials: N
authors.lastname: Ehara
authors.forename: Ryoji
authors.initials: R
authors.lastname: Taniguchi
authors.forename: Yoshisumi
authors.initials: Y
authors.lastname: Haruna
authors.forename: Neiko
authors.initials: N
authors.lastname: Ozasa
authors.forename: Naritatsu
authors.initials: N
authors.lastname: Saito
authors.forename: Takahiro
authors.initials: T
authors.lastname: Doi
authors.forename: Kozo
authors.initials: K
authors.lastname: Hoshino
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tamura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shizuta
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Abe
authors.forename: Masanao
authors.initials: M
authors.lastname: Toma
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Teramukai
authors.forename: Masanori
authors.initials: M
authors.lastname: Fukushima
authors.forename: Toru
authors.initials: T
authors.lastname: Kita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D017677:Age Distribution; D000367:Age Factors; D044466:Asian People; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007674:Kidney Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009204:Myocardial Revascularization / Q000009:adverse effects*; D011379:Prognosis; D012307:Risk Factors