title: Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.
abstract: At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use.
authors.affiliation: The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA. wwoodward@mdanderson.org
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Woodward
authors.forename: Robert G
authors.initials: RG
authors.lastname: Bristow
authors.forename: Michael F
authors.initials: MF
authors.lastname: Clarke
authors.forename: Robert P
authors.initials: RP
authors.lastname: Coppes
authors.forename: Massimo
authors.initials: M
authors.lastname: Cristofanilli
authors.forename: Dan G
authors.initials: DG
authors.lastname: Duda
authors.forename: John R
authors.initials: JR
authors.lastname: Fike
authors.forename: Dolores
authors.initials: D
authors.lastname: Hambardzumyan
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hill
authors.forename: Craig T
authors.initials: CT
authors.lastname: Jordan
authors.forename: Luka
authors.initials: L
authors.lastname: Milas
authors.forename: Frank
authors.initials: F
authors.lastname: Pajonk
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Curran
authors.forename: Adam P
authors.initials: AP
authors.lastname: Dicker
authors.forename: Yuhchyau
authors.initials: Y
authors.lastname: Chen
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000502:physiology; D035843:Biomedical Research; D015687:Cell Hypoxia; D002986:Clinical Trials as Topic; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D005434:Flow Cytometry / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000473:pathology; D033181:Information Dissemination; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009369:Neoplasms / Q000737:chemistry / Q000473:pathology / Q000628:therapy; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D018787:Radiation Oncology
chemical_list: D014408:Biomarkers, Tumor