title: [Effectiveness of treatment of single cerebral metastasis depending on prognostic groups (RPA RTOG)].
abstract: Our investigation was aimed at establishing a relationship between single metastases in the brain and a set of prognostic factors. It involved 278 patients treated at the Center in 1983-2003. The whole brain was irradiated in 273 while 159 of them (58.2%) received additional local irradiation of the brain. Single dosage of 2-2.5 Gy was administered to 158 (57.9%), 115--3Gy and more (42.1%). Mean total dosage was 36 Gy per metastasis for the whole brain and 46 Gy--for total plus local exposure. Among patients with favorable prognosis (RPA) were those aged up to 65, Karnofsky's index > or = 70%, with cured or controllable tumor and without extracranial metastases; poor prognosis--Karnofsky's index < or = 70%, irrespective of any other prognosticators, and intermediate prognosis--the remaining cases. The following four treatment modalities were used: 1) surgery --> radio- or radiochemotherapy (40); 2) chemotherapy > or = radiotherapy --> chemotherapy successively (56); (3) radiotherapy alone (110) and (4) simultaneous radiochemotherapy (72).
authors.forename: Z P
authors.initials: ZP
authors.lastname: Mikhina
authors.forename: S I
authors.initials: SI
authors.lastname: Tkachëv
authors.forename: O P
authors.initials: OP
authors.lastname: Trofimova
authors.forename: S M
authors.initials: SM
authors.lastname: Ivanov
authors.forename: S V
authors.initials: SV
authors.lastname: Medvedev
authors.forename: S N
authors.initials: SN
authors.lastname: Zakharov
authors.forename: V B
authors.initials: VB
authors.lastname: Krat
authors.forename: S V
authors.initials: SV
authors.lastname: Korgunov
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D016371:Cranial Irradiation / Q000379:methods; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D017567:Karnofsky Performance Status; D007680:Kidney Neoplasms / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000150:complications; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000556:secondary; D013736:Testicular Neoplasms / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000473:pathology; D014594:Uterine Neoplasms / Q000473:pathology