title: [Research of cellular toxic effect to Hep-2 of recombinant toxin MSH-Ang].
abstract: OBJECTIVE
  To study the cytotoxicity of recombinate toxin MSH-Ang to Hep-2.
  
  
  METHODS
  The depurated MSH-Ang were applied in cytotoxicity experiment, and the growth inhibiting action to laryngeal carcinoma cell Hep-2 were observed.
  
  
  RESULTS
  Recombination protein inhibited the growth of laryngeal carcinoma cell Hep-2, and its inhibiting action enhanced and corpuscular mortality rate increased along with the concentration increasing.
  
  
  CONCLUSIONS
  Recombinant toxin MSH-Ang can not only take special effect in tumors with high MSHR, but also target to many other popular tumors.
authors.affiliation: Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University Tongren Hospital, Beijing, 100730, China. zhouweiguosky@sohu.com
authors.forename: Weiguo
authors.initials: W
authors.lastname: Zhou
authors.forename: Xin
authors.initials: X
authors.lastname: Ni
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Huang
authors.forename: Jugao
authors.initials: J
authors.lastname: Fang
authors.forename: Demin
authors.initials: D
authors.lastname: Han
authors.forename: Dongdong
authors.initials: D
authors.lastname: Zhu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Dong
authors.forename: Zhanquan
authors.initials: Z
authors.lastname: Yang
mesh_terms: D042682:Angiopoietins / Q000235:genetics / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005818:Genetic Engineering; D006801:Humans; D007822:Laryngeal Neoplasms; D009074:Melanocyte-Stimulating Hormones / Q000235:genetics / Q000494:pharmacology*; D011995:Recombination, Genetic
chemical_list: D042682:Angiopoietins; D009074:Melanocyte-Stimulating Hormones