title: Diffuse proliferative glomerulonephritis associated with dermatomyositis with nephrotic syndrome.
abstract: We described a 44-year-old man developing dermatomyositis (DM) and nephrotic syndrome (NS). Renal biopsy revealed diffuse proliferative glomerulonephritis (DPGN) with depositions of immunoglobulin and complements. A combination therapy of steroid and cyclophosphamide (CTX) was found very effective for the patient. Chronic glomerulonephritis is rare in DM. In our review of related literature, membranous glomerulonephritis (MN) is the main type of glomerular lesion, another type is mesangial proliferative glomerulonephritis (mesPGN). Here we reported a case of DM associated with DPGN developing NS, which was not found in existing literature. Although glomerulonephritis is uncommon in patients with DM, renal pathology is not as simplex as previously thought, and treatment with steroid or/and cytotoxic drugs is favorable for prognosis.
authors.affiliation: Department of Rheumatology and Immunology, West China Hospital of Sichuan University, 610041, Chengdu, Sichuan, China.
authors.forename: Qibing
authors.initials: Q
authors.lastname: Xie
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Nanping
authors.initials: N
authors.lastname: Yang
authors.forename: Geng
authors.initials: G
authors.lastname: Yin
mesh_terms: D000328:Adult; D052279:Creatine Kinase, MB Form / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000627:therapeutic use; D003882:Dermatomyositis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D007686:Kidney Tubules, Distal / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D013256:Steroids; D003520:Cyclophosphamide; D052279:Creatine Kinase, MB Form