Investigation of niacin on parameters of metabolism in a physiologic dose: randomized, double-blind clinical trial with three different dosages.
The aim of this double-blind, placebo-controlled cross-over design trial was to assess the safety of a multi-vitamin preparation containing nicotinic acid in a physiological dose. Seventy-two healthy volunteers took part in this trial. At six consecutive time-points, we systematically documented blood pressure, pulse, skin temperature and flushing symptoms after an oral dose of up to 50.1 mg nicotinic acid. The results suggest that nicotinic acid in a dosage of 16.7 mg does not cause flushing symptoms. In higher doses up to 50.1 mg, flushing symptoms are sporadically possible. There was no physiologically relevant change regarding the central metabolic parameters blood pressure, pulse and skin temperature.
Schweikart
Jennifer
J
BioTeSys GmbH, Esslingen, Germany. j.schweikart@biotesys.de
Reimann
Jürgen
J
Schön
Christiane
C
D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D018592:Cross-Over Studies; D004032:Diet; D019587:Dietary Supplements / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D005483:Flushing / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000008:administration & dosage / Q000009:adverse effects*; D009536:Niacinamide / Q000009:adverse effects; D011674:Pulse; D012881:Skin Temperature; D011795:Surveys and Questionnaires; D013997:Time Factors; D014815:Vitamins / Q000008:administration & dosage; D055815:Young Adult
D014815:Vitamins; D009536:Niacinamide; D009525:Niacin