Renin system of the kidney in ISIAH rats with inherited stress-induced arterial hypertension.
The renal renin system was studied in ISIAH rats with inherited stress-induced arterial hypertension. The expression of genes for renin (Ren1) and cyclooxygenase (Cox-2) was evaluated in renal tissue of ISIAH and WAG rats (normotensive control). Basal gene expression for Ren1 and Cox-2 in ISIAH rats was much lower than in WAG rats. Water deprivation for 11 h was followed by a 4-fold increase in Cox-2 gene expression in ISIAH rats. The increase in gene expression was insignificant in WAG rats (by 30%). Renin gene expression in renal tissue of ISIAH and WAG rats remained practically unchanged after water deprivation. We conclude that a change in Cox-2 gene expression after short-term water deprivation serves as a reliable criterion for functional strain of the renal renin system in hypertensive ISIAH rats.
Fedoseeva
L A
LA
Siberian Division of the Russian Academy of Sciences, Institute of Cytology and Genetics, Novosibirsk, Russia.
Dymshits
G M
GM
Markel
A L
AL
Jakobson
G S
GS
D000818:Animals; D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000502:physiology; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D016133:Polymerase Chain Reaction; D051381:Rats; D012083:Renin / Q000235:genetics / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*; D013312:Stress, Physiological
D051546:Cyclooxygenase 2; D012083:Renin