title: Human choriogonadotropin prior to controlled ovarian stimulation and in vitro fertilization improves implantation, and pregnancy rates.
abstract: OBJECTIVE
  Our purpose was to retrospectively compare controlled ovarian stimulation(COH) in IVF cycles with administration of hCG on the day of menses (D1-hCG) with women not receiving hCG at day 1 of menses (Control).
  
  
  METHODS
  Data on maternal age, endocrine profile, amount of rFSH required, embryo characteristics, implantation and pregnancy rates were recorded for comparison between D1-hCG (n = 36) and Control (n = 64).
  
  
  RESULTS
  Dose of rFSH required to accomplish COH was significantly lower in D1-hCG. Following ICSI, more top-quality embryos were available for transfer per patient in the D1-hCG and biochemical pregnancy rates per transfer were significantly higher in the D1-hCG. Significantly higher implantation and on-going pregnancy rates per embryo transfer were observed in D1-hCG (64%) compared to Control (41%).
  
  
  CONCLUSIONS
  Administration of D1-hCG prior to COH reduces rFSH use and enhances oocyte developmental competence to obtain top quality embryos, and improves implantation and on-going pregnancy rates. At present it is not clear if the benefit is related to producing an embryo that more likely to implant or a more receptive uterus, or merely fortuitous and related to the relatively small power of the study.
authors.affiliation: Huntington Center for Reproductive Medicine of Brazil, Ipanema, Rio de Janeiro, 22420-030, Brazil.
authors.forename: Eduardo L
authors.initials: EL
authors.lastname: Motta
authors.forename: Gary D
authors.initials: GD
authors.lastname: Smith
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Serafini
authors.forename: Marcio
authors.initials: M
authors.lastname: Coslovsky
authors.forename: Pericles
authors.initials: P
authors.lastname: Hassun
authors.forename: Andre M
authors.initials: AM
authors.lastname: Rocha
authors.forename: Isaac
authors.initials: I
authors.lastname: Yadid
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin