Studying the photoprotective activity of a new class of heteroaromatic antioxidants.
Photoprotective activity of heteroaromatic compounds (derivatives of 3-hydroxypyridine, amino-6-hydroxybenzothiazole, and 5-hydroxybenzimidazole) was studied in the system of UV-induced cardiolipin peroxidation. Although all three compounds had the antioxidant effect during free radical oxidation of luminol, only derivatives of amino-6-hydroxybenzothiazole and 5-hydroxybenzimidazole inhibited the process of UV-induced lipid peroxidation. The 3-hydroxypyridine derivative did not inhibit UV-induced cardiolipin peroxidation, which was probably related to degradation of this compound under the influence of UV light and formation of degradation products that cannot inhibit free radical processes.
Sakina
N L
NL
N M Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia. nsakina@mail.ru
Golubkov
A M
AM
Smirnov
L D
LD
Ostrovsky
M A
MA
Dontsov
A E
AE
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry; D002308:Cardiolipins / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects*; D015394:Molecular Structure; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D011725:Pyridines / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry; D014466:Ultraviolet Rays
D000975:Antioxidants; D001562:Benzimidazoles; D002308:Cardiolipins; D005609:Free Radicals; D011725:Pyridines; D013844:Thiazoles; C077548:6-hydroxybenzothiazole; C036435:5-hydroxybenzimidazole; C023500:3-hydroxypyridine