title: Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole.
abstract: Combinatorial biosynthesis meets combinatorial pharmacology, cyanobacterial style: A new antimitotic natural product with features of both dolastatins 10 and 15 was isolated from the same Floridian Symploca sp. sample that produced the histone deacetylase inhibitor largazole. Both agents in combination are more effective in inhibiting cancer cell proliferation than either agent alone.
authors.affiliation: Department of Medicinal Chemistry, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA.
authors.forename: Kanchan
authors.initials: K
authors.lastname: Taori
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Liu
authors.forename: Valerie J
authors.initials: VJ
authors.lastname: Paul
authors.forename: Hendrik
authors.initials: H
authors.lastname: Luesch
mesh_terms: D023181:Antimicrobial Cationic Peptides; D050256:Antimitotic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000737:chemistry* / Q000494:pharmacology; D002453:Cell Cycle; D045744:Cell Line, Tumor; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D023181:Antimicrobial Cationic Peptides; D050256:Antimitotic Agents; D047630:Depsipeptides; D056572:Histone Deacetylase Inhibitors; D010455:Peptides; D013844:Thiazoles; C534687:gallinamide A; C527895:largazole; C075610:dolastatin 15; D006655:Histone Deacetylases; C064570:dolastatin 10