title: A new, rapid, and promising approach to aerosol immunization: inflatable bags and valved masks.
abstract: Booster doses of MMR vaccine equal in dosage to injected doses were aerosolized into a 3/4 l bag that inflated in 4s. The bag was then attached to valved masks, and its contents rapidly inhaled in one or two deep breaths by preschool Mexican children. Antibody responses in the children exposed to the aerosolized measles component were superior to those noted after injection, while responses to the mumps and rubella components were equivalent. The new method appears to be effective, safe, and has several advantages over previously used methods. Further explorations of the approach seem merited.
authors.affiliation: bennettjv@earthlink.net
authors.forename: John V
authors.initials: JV
authors.lastname: Bennett
authors.forename: Jorge
authors.initials: J
authors.lastname: Fernandez de Castro
authors.forename: Roberto Martinez
authors.initials: RM
authors.lastname: Poblete
authors.forename: Maria Luisa Garcia
authors.initials: ML
authors.lastname: Alcantara
authors.forename: Esperanza Gallardo
authors.initials: EG
authors.lastname: Diaz
authors.forename: Miguel Angel Molina
authors.initials: MA
authors.lastname: Angeles
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Wong Chew
authors.forename: Eloisa Arias
authors.initials: EA
authors.lastname: Toledo
authors.forename: Clyde
authors.initials: C
authors.lastname: Witham
authors.forename: Jose Ignacio
authors.initials: JI
authors.lastname: Santos Preciado
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage*; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004864:Equipment and Supplies; D005260:Female; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008397:Masks; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D008800:Mexico
chemical_list: D000336:Aerosols; D000914:Antibodies, Viral; D022542:Measles-Mumps-Rubella Vaccine