Molecular dynamics of some pentapeptides having a strong tendency to helical conformation.
Some pentapeptides with higher alpha-helical tendency possess typical sequence pattern, such as "+ - + + - - +", "+ - - + - - +", "+ - + - - - +", and " - + + - - - +" ( "+" = D,N,E,Q,K,R,T,C, or H; "-" = L,I,V, or A), especially symmetrical motifs (a pair of reverse sequences beside palindromic segments), such as ALALA, QQAQE/EQAQQ, and REALE/ELAER, hint that the nascent peptide can fold a certain conformation in a two-way folding fashion.
Huang
Zhuo-Ran
ZR
State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210093, China.
Zhu
Tong-Yang
TY
Wang
Ting-Ting
TT
Wang
Xiao-Ning
XN
Yang
Jie
J
D000595:Amino Acid Sequence; D015233:Models, Statistical; D056004:Molecular Dynamics Simulation; D009010:Monte Carlo Method; D009842:Oligopeptides / Q000737:chemistry* / Q000235:genetics; D017433:Protein Structure, Secondary
D009842:Oligopeptides