title: Descending necrotizing mediastinitis of odontogenic origin.
abstract: Descending Necrotizing Mediastinitis is a rare complication that can be secondary to dental infections or surgical procedures involving the oral region. Despite a prompt pharmacological therapy and surgical intervention, a delayed diagnosis is still responsible for a too high mortality rate (about 40%). We present a review of the current literature on Descending Necrotizing Mediastinitis, focusing on the evolution of its management from Pearse to today. In particular, recent patents focused on novel compositions and methods to prevent and treat oral infections.
authors.affiliation: University of Trieste, Italy. m.biasotto@fmc.units.it
authors.forename: Matteo
authors.initials: M
authors.lastname: Biasotto
authors.forename: Silvia
authors.initials: S
authors.lastname: Chiandussi
authors.forename: Fulvia
authors.initials: F
authors.lastname: Costantinides
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Lenarda
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005491:Focal Infection, Dental / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D006801:Humans; D008480:Mediastinitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D010330:Patents as Topic; D017703:Retropharyngeal Abscess / Q000150:complications / Q000188:drug therapy / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents