Specific features of the immune response in old recipient mice to cell therapy.
Implantation of somatic cells from autopsy specimens (15-18 weeks gestation) had a modulatory effect on immunogenesis in old mice. Activation of the immune system in recipient animals after administration of somatic cells reflects a multistage influence of test preparation. The observed changes were reversible. A progressive decrease in activation of the immune system in recipient mice was not accompanied by the development of pathological changes. Repeated implantation was required to maintain these processes.
Khlystova
Z S
ZS
Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. morfolhum@mail.ru
Kalinina
I I
II
Shmeleva
S P
SP
Kuznetsova
L V
LV
Minina
T A
TA
Tokareva
O I
OI
D000818:Animals; D017690:Cell Transplantation; D051379:Mice; D008808:Mice, Inbred CBA