Association of parathyroid adenoma and pregnancy with preeclampsia.
OBJECTIVE
Case reports have described associations between calcium metabolism disturbances and primary hyperparathyroidism with preeclampsia, suggesting parathyroid involvement in preeclampsia etiology. This study examines whether parathyroid adenoma, the main cause of hyperparathyroidism, diagnosed and treated before pregnancy is associated with preeclampsia.


METHODS
We conducted a register-based study to assess the association between parathyroid adenoma and subsequent preeclampsia.


METHODS
Births among Sweden's general population were studied.


METHODS
The study population included 52 women with a diagnosis of parathyroid adenoma and 519 without, all of whom had a subsequent singleton pregnancy between 1973 and 1997.


METHODS
We performed a conditional logistic regression investigating the association of parathyroid adenoma with subsequent preeclampsia in the first singleton pregnancy with adjustment for potential confounding factors.


METHODS
The main outcome was a diagnosis of preeclampsia that does not include women with prior chronic hypertension. To ensure that treatment of parathyroid adenoma was completed before pregnancy, those with a diagnosis of parathyroid adenoma made less than 2 yr before delivery (and the matched comparison women) were excluded.


RESULTS
Statistically, parathyroid adenoma prior to delivery is significantly (P < 0.001) associated with preeclampsia, producing an adjusted odds ratio of 6.89 (95% confidence interval, 2.30, 20.58).


CONCLUSIONS
A history of parathyroid adenoma should be viewed as a risk for preeclampsia.
Hultin
Hella
H
Department of Surgical Sciences, University Hospital, SE-751 85 Uppsala, Sweden.
Hellman
Per
P
Lundgren
Ewa
E
Olovsson
Matts
M
Ekbom
Anders
A
Rastad
Jonas
J
Montgomery
Scott M
SM
D000236:Adenoma / Q000150:complications*; D000328:Adult; D005260:Female; D006801:Humans; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000150:complications*; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic
D010281:Parathyroid Hormone