How to Grb2 a Gab.
In this issue of Structure, Harkiolaki et al. use crystallography, peptide arrays and isothermal calorimetry to provide a detailed insight into the interaction between the C-terminal SH3 domain of adaptor protein Grb2 bound to the docking protein Gab2.
Wöhrle
Franziska U
FU
Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-University, 79104 Freiburg, Germany.
Daly
Roger J
RJ
Brummer
Tilman
T
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D020816:Amino Acid Motifs / Q000235:genetics; D001665:Binding Sites / Q000235:genetics; D051380:GRB2 Adaptor Protein / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D017434:Protein Structure, Tertiary / Q000235:genetics; D018909:src Homology Domains / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; C490895:GAB2 protein, human; D051380:GRB2 Adaptor Protein