[Immunogenetic criteria for prediction of mixed hepatitis A + B].
The investigation has revealed that mixed hepatitis A + B is a genetically determined disease. HLA-A10, B21, Cw2, Cw5, A10-A19, B8-B13, B21-B35, A3-B21, and A9-B21 are immunogenetic markers of this disease. The carriers of HLA-B21, Cw5, A3-B21, and A9-B21 and those of HLA-A10, A10-A19, and A10-B14 are at high risk for this infection among men and women, respectively. The findings of the distribution of HLA antigens and their combinations in mixed infection with hepatitis A and B viruses allow prediction of its occurrence (including the consideration of examinees' gender) which will assist in solving the matter of timely prophylaxis of this pathology.
Bondarenko
A L
AL
Ustiuzhaninov
V N
VN
Vozhegova
N P
NP
Strazhnikova
G A
GA
D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000175:diagnosis / Q000276:immunology; D005260:Female; D015234:HLA-A Antigens / Q000276:immunology; D015235:HLA-B Antigens / Q000276:immunology; D006506:Hepatitis A / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D006509:Hepatitis B / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007125:Immunogenetics / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
D015234:HLA-A Antigens; D015235:HLA-B Antigens