Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome treated with a combination of isotretinoin and pamidronate.
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a clinically heterogeneous entity, encompassing a variety of debilitating conditions that have in common inflammation of the skeletal system and skin. To date, there is a paucity of documented efficacious treatment options. We report a 48-year-old man with skeletal and cutaneous signs and symptoms who improved dramatically after treatment with a combination of isotretinoin and pamidronate. This report provides an alternative treatment regimen for SAPHO that addresses the possible underlying pathophysiology of this likely underdiagnosed syndrome.
Galadari
Hassan
H
Department of Dermatology, Boston University School of Medicine, Boston, MA, USA.
Bishop
Alyssa G
AG
Venna
Suraj S
SS
Sultan
Emad
E
Do
Daihung
D
Zeltser
Ross
R
D017486:Acneiform Eruptions / Q000188:drug therapy*; D004164:Diphosphonates / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D015576:Hyperostosis / Q000188:drug therapy*; D015474:Isotretinoin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010000:Osteitis / Q000188:drug therapy*; D000077268:Pamidronate; D011565:Psoriasis / Q000188:drug therapy*; D012871:Skin Diseases / Q000188:drug therapy*; D013577:Syndrome; D013585:Synovitis / Q000188:drug therapy*
D004164:Diphosphonates; D015474:Isotretinoin; D000077268:Pamidronate