Effects of exogenous application of corticotropin-releasing hormone to slices of the olfactory cortex from rats with an active strategy of adaptive behavior on the water-immersion model of depression.
Experiments were performed on male Wistar rats. The specimens with an active strategy of behavior were exposed to unavoidable water-immersion stress. Surviving slices of the olfactory cortex were obtained 10 days after stress. The neurohormone had a strong inhibitory effect in 40% slices from active rats. The activity of glutamate receptors decreased, while the function of GABA receptors increased in 60% slices. Our results indicate that the depressive state of behaviorally active animals due to exposure to unavoidable stress is not necessarily mediated by the corticoliberinergic mechanisms in cortical structures.
Mokrushin
A A
AA
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. mok@inbox.ru
Hama-Murad
A H
AH
Semenova
O G
OG
Shalyapina
V G
VG
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy*; D004195:Disease Models, Animal; D005071:Evoked Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009833:Olfactory Pathways / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D051381:Rats
D003346:Corticotropin-Releasing Hormone