Diversity in genes responsible for lifestyle-related diseases in Asia-Pacific region.
In Asia-Pacific countries, both environmental modernization and hereditary traits of Mongoloid reported to cause rapid increase in lifestyle-related diseases (LRD). However, reproducibility of reported responsive-factors is low. To examine this, a decision-tree method of complexity-model was applied to select LRD-responsive-factors. Genomic DNA was collected from Asia-Pacific regions. Single nucleotide polymorphisms (SNPs) on genomic DNA were determined as hereditary-trait-factor. Three indices of LRD (BMI, body fat, and serum leptin levels) were classified according to published criteria. WEKA Machine-learning system was used as decision-tree software. Age was added as a factor with different dimension. Selected factors were validated by other statistical methods. In Thai-males, GLUT) (glucose-transporter 1)-SNP was most-responsive to body fat, followed by USF1-SNP (transcription-factor for lipid metabolism). Differences between genotypes were validated (P = .002 for GLUT1 by Levene's, P = .071 for USF1 by ANOVA). Responsive-factors of Thai-females, Palau-males and Palau-females, were consisted with SNPs and age, and varied by groups. Convincing responsive-factors were not selected from mixed-data. Decision-tree-analysis successfully selected the convincing results. Responsive-factors differed by ethnic group and gender.
Yanagisawa
Yoshiko
Y
Division of Human Genetics, Jichi Medical University, Japan.
Munkhtulga
Lkhagvasuren
L
Nakayama
Kazuhiro
K
Iwamoto
Sadahiko
S
Charupoonphol
Phitaya
P
Supannnatas
Somjit
S
Kuartei
Stevenson
S
Chimedregzen
Ulziiburen
U
Kawabata
Terue
T
Kaneko
Yoshinori
Y
Watanabe
Sanae
S
Sakuma
Mitsuru
M
Komatsu
Fumio
F
Hasegawa
Kyoko
K
Kagawa
Yasuo
Y
D001208:Asia; D015992:Body Mass Index; D027342:Excitatory Amino Acid Transporter 2 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D020738:Leptin / Q000097:blood; D008019:Life Style; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D019029:Palau; D020641:Polymorphism, Single Nucleotide; D051720:Upstream Stimulatory Factors / Q000235:genetics
D027342:Excitatory Amino Acid Transporter 2; D020738:Leptin; C497181:USF1 protein, human; D051720:Upstream Stimulatory Factors