3-Hydroxy-2-phenyl-4(1H)-quinolinones as promising biologically active compounds.
2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.
Hradil
P
P
Department of Organic Chemistry, Palacký University, Tr. Svobody 8, 771 46 Olomouc, Czech Republic.
Hlavác
J
J
Soural
M
M
Hajdúch
M
M
Kolár
M
M
Vecerová
R
R
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D015363:Quinolones