Proteomics in protein misfolding diseases.
Protein misfolding and deposition as amyloid, with consequent tissue damage, plays a key role in the group of diseases generically termed amyloidoses. In the systemic forms, amyloid deposition is widespread and causes severe dysfunction of vital organs. Proteomic analysis, thanks to its versatility and the comprehensiveness of information obtained, is an ideal tool for the study of systemic amyloidoses. It has been successfully employed in the characterization of the circulating amyloidogenic precursors and the analysis of affected tissues, for the diagnostic identification of the fibril components and for characterizing disease-related changes in protein expression. We present the developments in the field of proteomics applied to systemic amyloidoses, and discuss the perspectives opened in the study of these diseases.
Stoppini
Monica
M
Department of Biochemistry, University of Pavia, Pavia, Italy.
Obici
Laura
L
Lavatelli
Francesca
F
Giorgetti
Sofia
S
Marchese
Loredana
L
Moratti
Remigio
R
Bellotti
Vittorio
V
Merlini
Giampaolo
G
D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D006801:Humans; D017510:Protein Folding; D040901:Proteomics / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D000682:Amyloid