title: Sulfasalazine-induced hypersensitivity syndrome in a 15-year-old boy associated with human herpesvirus-6 reactivation.
abstract: Drug-induced hypersensitivity syndrome (DIHS) is characterized by high fever, facial edema, diffuse maculopapular eruption, and multiorgan involvement. Human herpesvirus (HHV)-6 reactivation is an accepted criterion for the diagnosis of DIHS and has prognostic importance. We report a 15-year-old boy with juvenile rheumatoid arthritis who developed DIHS due to sulfasalazine, associated with reactivation of HHV-6.
authors.affiliation: Department of Dermatology, Mustafa Kemal University, Antakya, Turkey. didemaltiner@yahoo.com
authors.forename: Didem Didar
authors.initials: DD
authors.lastname: Balci
authors.forename: Erdal
authors.initials: E
authors.lastname: Peker
authors.forename: Nizami
authors.initials: N
authors.lastname: Duran
authors.forename: Cigdem Asena
authors.initials: CA
authors.lastname: Dogramaci
mesh_terms: D000293:Adolescent; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001171:Arthritis, Juvenile / Q000150:complications / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology*; D015654:Herpesvirus 6, Human / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D008297:Male; D019349:Roseolovirus Infections / Q000150:complications; D012460:Sulfasalazine / Q000009:adverse effects*
chemical_list: D018501:Antirheumatic Agents; D012460:Sulfasalazine