Efficacy of sumatriptan in two pediatric cases with abdominal pain-related functional gastrointestinal disorders: does the mechanism overlap that of migraine?
We successfully treated 2 pediatric cases of abdominal pain-related functional gastrointestinal disorder with sumatriptan. When 9 years old, patient 1 developed periodic abdominal pain that was intractable to medication and remitted spontaneously. She was diagnosed with abdominal migraine, categorized as H2c in the Rome III criteria for functional gastrointestinal disorders. At age 12, intranasal sumatriptan relieved her pain, and her attacks halted 2 years later. Patient 2 was a 9-year-old girl diagnosed with attention-deficit hyperactivity disorder (ADHD), who began to have intermittent abdominal pain of variable severity, which sometimes restricted daily activity. She was diagnosed with childhood functional abdominal pain syndrome, categorized as H2d1 using the Rome III criteria. Intranasal sumatriptan also relieved her pain. These cases suggest that the mechanism of pain in abdominal pain-related functional gastrointestinal disorders is similar to that of migraine, with probable central hypersensitivity, at least in a subset of cases.
Kakisaka
Yosuke
Y
Department of Pediatrics, Tohoku University School of Medicine, Sendai, Miyagi, 980-8574, Japan. kakisuke@mui.biglobe.ne.jp
Wakusawa
Keisuke
K
Haginoya
Kazuhiro
K
Saito
Akiko
A
Uematsu
Mitsugu
M
Yokoyama
Hiroyuki
H
Sato
Tetsuo
T
Tsuchiya
Shigeru
S
D015746:Abdominal Pain / Q000188:drug therapy* / Q000209:etiology; D000281:Administration, Intranasal; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D005767:Gastrointestinal Diseases / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D018170:Sumatriptan / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D000700:Analgesics; D018170:Sumatriptan