Effects of autologous bone marrow cells on apoptosis and regeneration of non-healing autoimmune gastric ulcers.
The effects of cultured autologous bone marrow multipotent mesenchymal stromal cells on apoptosis and healing processes were studied on the model of non-healing gastric ulcers in rats. Bone marrow multipotent mesenchymal stromal cells inhibited apoptosis in epitheliocytes of the gastric mucosa and stimulated ulcer healing.
Askarov
M B
MB
Institute of Transplantology and Artificial Organs, Federal Agency of Medical Technologies, Russia. illak@mail.ru
Vostrikova
O F
OF
Vorobjova
N N
NN
Onishenko
N A
NA
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D005753:Gastric Mucosa / Q000166:cytology; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008233:Lymphotoxin-alpha / Q000097:blood; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D039902:Multipotent Stem Cells / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000097:blood / Q000628:therapy*; D017154:Stromal Cells / Q000166:cytology*; D014182:Transplantation, Autologous / Q000379:methods*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D053583:Interleukin-1beta; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma