title: Circulating TGF-beta1 as a reliable biomarker for chronic kidney disease progression in the African-American population.
abstract: Progressive renal fibrosis is common to all chronic kidney diseases (CKD). Suthanthiran and colleagues identified a positive association between transforming growth factor-beta1 and several risk factors for CKD progression in African Americans but not in whites. This study offers a possible explanation for the higher prevalence of end-stage renal disease in African Americans and highlights the need for a better therapeutic strategy for this population.
authors.affiliation: Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: Soo Bong
authors.initials: SB
authors.lastname: Lee
authors.forename: Keizo
authors.initials: K
authors.lastname: Kanasaki
authors.forename: Raghu
authors.initials: R
authors.lastname: Kalluri
mesh_terms: D001741:Black or African American / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000208:ethnology*; D008954:Models, Biological; D044382:Population Groups / Q000706:statistics & numerical data*; D015995:Prevalence; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D014481:United States / Q000453:epidemiology
chemical_list: D015415:Biomarkers; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1