Antitrypanosomal activity of polycarpol from Piptostigma preussi (Annonaceae).
Polycarpol, sitosterol and sitosterol-3-O-beta-D-glucoside isolated for the first time from Piptostigma preussi (Annonaceae) occur regularly in some Annonaceae such as Piptostigma genus. Polycarpol exhibits interesting antitrypanosomal activity with an ED(50) value of 5.11 microM on Trypanosoma brucei cells. Moreover, it inhibits T. brucei glycolytic enzymes GAPDH and PFK with IC(50) values of 650 and 180 microM respectively.
Ngantchou
Igor
I
Laboratory of Bio-organic and Medicinal Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Box 812 Yaounde, Cameroon. nwete@yahoo.fr
Nkwengoua
Ernestine
E
Nganso
Yves
Y
Nyasse
Barthelemy
B
Denier
Colette
C
Hannaert
Veronique
V
Schneider
Bernd
B
D029061:Annonaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems; D011084:Polycyclic Aromatic Hydrocarbons / Q000302:isolation & purification / Q000494:pharmacology*; D012855:Sitosterols / Q000302:isolation & purification; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects* / Q000201:enzymology
D004791:Enzyme Inhibitors; D005960:Glucosides; D010936:Plant Extracts; D011084:Polycyclic Aromatic Hydrocarbons; D012855:Sitosterols; D014344:Trypanocidal Agents; C460801:polycarpol