title: [Effect of static magnetic field on deep wound healing of SD rats].
abstract: OBJECTIVE
  To investigate the effect of static magnetic field on deep wound healing of SD rats and VEGF during the wound healing and different strength static magnetic field on deep wound healing of SD rats.
  
  
  METHODS
  Divided forty-eight SD rats into three groups: 0.16 T magnetic disk treatment (0.16 T group), 0.32 T magnetic disk treatment (0.32 T group), control group. General wounds healing situation was observated on the 3, 6, 9, 12 day. The area of every wound was calculated. The tissue of granulation was dyeing by immune tissue chemical decoration method, in which VEGF protein content with its range in tissue was measured.
  
  
  RESULTS
  The healing index of 0.16 T magnetic group wounds were larger than that of control group on 6th and 9th day, there were statistical difference. The healing index of 0.32 T magnetic group wounds were larger than that of control group on 3rd, 6th, 9th and 12th day, there were statistical difference. The healing index of 0.32 T group wounds contrasted to that of 0.16 T group wounds had no statistical significance. Observation of VEGF at the course of wound healing:the expressing of VEGF in magnetic group wounds on 3rd and 6th was stronger than in control group wounds, there were statistical difference. While there were no obvious difference between them on 9th and 12th day (P>0.05). But the contrast between that in 0.32 T group and in 0.16 T group had no statistical difference. The expressing strength of VEGF in magnetic group reached the peak amplitude on the 6th day, and that in control group reached peak amplitude on 9th day. And the peak amplitude of magnetic group was stronger than that of control group.
  
  
  CONCLUSIONS
  Static magnetic disc of 0.16T and 0.32 T can promote deep wound of SD rats heal. The mechanism of static magnetic field promoting wound heal may be relative to the expressing highly of VEGF during early and middle time.
authors.affiliation: Department of Orthopaedics, the Second Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang, China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Shen
authors.forename: Wei-Shan
authors.initials: WS
authors.lastname: Chen
authors.forename: Chang-Xing
authors.initials: CX
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Dong
mesh_terms: D000818:Animals; D055909:Magnetic Field Therapy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000502:physiology / Q000528:radiation effects*; D012867:Skin / Q000528:radiation effects*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism; D014945:Wound Healing / Q000528:radiation effects*
chemical_list: D042461:Vascular Endothelial Growth Factor A