Sequential addition reactions of two molecules of Grignard reagents to thioformamides.
Sequential addition reactions of two molecules of Grignard reagents to thioformamides were found to yield tertiary amines in an efficient manner. The addition of two different Grignard reagents can be accomplished by using one equivalent of arylmagnesium reagent in the first step. In the second step, a variety of reagents such as alkyl, alkenyl, aryl, and alkynyl reagents were used to afford the corresponding amines in good to high yields.
Murai
Toshiaki
T
Department of Chemistry, Gifu University, Yanagido, Gifu 501-1193, Japan. mtoshi@gifu-u.ac.jp
Ui
Kazuki
K
Narengerile
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D005559:Formamides / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000588:Amines; D005559:Formamides; D007202:Indicators and Reagents; D009942:Organometallic Compounds; C009463:thioformamide