title: The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part II: implant surgery, prosthodontics, and survival.
abstract: Extensive bone grafting remains a delicate procedure, due to the slow and difficult integration of the grafted material into the physiological architecture. The recent use of platelet concentrates aims to improve this process of integration by accelerating bone and mucosal healing. Choukroun's platelet-rich fibrin (PRF) is a healing biomaterial that concentrates in a single autologous fibrin membrane, most platelets, leukocytes, and cytokines from a 10-mL blood harvest, without artificial biochemical modification (no anticoagulant, no bovine thrombin). In this second part, we describe the implant and prosthetic phases of a complex maxillary rehabilitation, after preimplant bone grafting using allograft, Choukroun's PRF membranes, and metronidazole. Twenty patients were treated using this new technique and followed up during 2.1 years (1-5 years). Finally, 184 dental implants were placed, including 54 classical screw implants (3I, Palm Beach Gardens, FL) and 130 implants with microthreaded collar (46 from AstraTech, Mölndal, Sweden; 84 from Intra-Lock, Boca Raton, FL). No implant or graft was lost in this case series, confirming the validity of this reconstructive protocol. However, the number of implants used per maxillary rehabilitation was always higher with simple screw implants than with microthreaded implants, the latter presenting a stronger initial implant stability. Finally, during complex implant rehabilitations, PRF membranes are particularly helpful for periosteum healing and maturation. The thick peri-implant gingiva is related to several healing phases on a PRF membrane layer and could explain the low marginal bone loss observed in this series. Microthreaded collar and platform-switching concept even improved this result. Multiple healing on PRF membranes seems a new opportunity to improve the final esthetic result.
authors.affiliation: Department of Periodontology, Turin University, Turin, Italy.
authors.forename: Alain
authors.initials: A
authors.lastname: Simonpieri
authors.forename: Marco
authors.initials: M
authors.lastname: Del Corso
authors.forename: Gilberto
authors.initials: G
authors.lastname: Sammartino
authors.forename: David M
authors.initials: DM
authors.lastname: Dohan Ehrenfest
mesh_terms: D016301:Alveolar Bone Loss / Q000517:prevention & control; D000540:Alveolar Ridge Augmentation / Q000379:methods; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D001792:Blood Platelets / Q000502:physiology*; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods / Q000502:physiology; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017267:Dental Prosthesis Design; D019094:Dental Prosthesis, Implant-Supported; D005260:Female; D005337:Fibrin / Q000502:physiology*; D005881:Gingiva / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D008297:Male; D008437:Maxilla / Q000601:surgery*; D008567:Membranes, Artificial; D008795:Metronidazole / Q000494:pharmacology; D008875:Middle Aged
chemical_list: D000891:Anti-Infective Agents, Local; D015921:Dental Implants; D008567:Membranes, Artificial; D008795:Metronidazole; D005337:Fibrin