[Expression of transforming growth factor beta1 in human vocal fold polyps].
OBJECTIVE
To analyze the expression of transforming growth factor-beta1 (TGF-beta1) in human vocal fold polyps, and explore the pathogenesis of vocal fold polyp.


METHODS
The expression of TGF-beta1 were detected in 37 examples of vocal fold polyps and 11 healthy vocal folds by immunohistochemical staining (SP method). Meanwhile, the positive results were compared.


RESULTS
The percent of positive expression of TGF-beta1 was 56.76% and the number of positive cells was 22.55 +/- 27.31 in vocal fold polyps, both of which were significantly increased compared with the percent of positive expression of TGF-beta1 (18.18%) and the number of positive cells (2.53 +/- 3.75) in healthy vocal folds (P<0.05). The positive expression of TGF-beta1 in stroma cells of vocal cord polyps was significantly higher than that in the healthy vocal cords. There was no significant difference of TGF-beta1 between the vocal fold polyps of male and female (P>0.05).


CONCLUSIONS
TGF-beta1 may participate in some pathologic changes in vocal cord polyps, such as extracellular matrix accumulation, local fibrosis and formation and development of vocal cord polyps. Manipulating the TGF-beta1 expression in vocal cord polyps may supply a new treatment method.
Liu
Tao
T
Department of Otolaryngology, the Second Affiliated Hospital of Kunming Medical College, Kunming, 650101, China.
Wu
Ping
P
Zheng
Mingxiu
M
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000378:metabolism* / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*; D014827:Vocal Cords / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
D053773:Transforming Growth Factor beta1