title: The in situ structural characterization of the influenza A virus matrix M1 protein within a virion.
abstract: The first attempt has been made to suggest a model of influenza A virus matrix M1 protein spatial structure and molecule orientation within a virion on the basis of tritium planigraphy data and theoretical prediction results. Limited in situ proteolysis of the intact virions with bromelain and surface plasmon resonance spectroscopy study of the M1 protein interaction with lipid coated surfaces were used for independent confirmation of the proposed model.
authors.affiliation: Department of Substance Structure, N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Shishkov
authors.forename: Elena N
authors.initials: EN
authors.lastname: Bogacheva
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Dolgov
authors.forename: Alexey L
authors.initials: AL
authors.lastname: Chulichkov
authors.forename: Denis G
authors.initials: DG
authors.lastname: Knyazev
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Fedorova
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Ksenofontov
authors.forename: Larisa V
authors.initials: LV
authors.lastname: Kordyukova
authors.forename: Elena V
authors.initials: EV
authors.lastname: Lukashina
authors.forename: Vladimir M
authors.initials: VM
authors.lastname: Mirsky
authors.forename: Lyudmila A
authors.initials: LA
authors.lastname: Baratova
mesh_terms: D001963:Bromelains / Q000378:metabolism; D018360:Crystallography, X-Ray; D006389:Hemagglutinins, Viral / Q000737:chemistry; D053122:Influenza A Virus, H3N2 Subtype / Q000737:chemistry*; D007553:Isotope Labeling; D007700:Kinetics; D008958:Models, Molecular; D020349:Surface Plasmon Resonance; D014316:Tritium; D014763:Viral Matrix Proteins / Q000737:chemistry*; D014771:Virion / Q000737:chemistry* / Q000378:metabolism
chemical_list: D006389:Hemagglutinins, Viral; C488936:M1 protein, Influenza A virus; D014763:Viral Matrix Proteins; D014316:Tritium; D001963:Bromelains