title: Fabrication and characterization of pseudo-ceramide-based liposomal membranes.
abstract: We present a facile and straightforward method to fabricate liposomal membranes with a significantly stable lamellar structure consisting of pseudo-ceramide, fatty acid, and cholesterol. Characterizing their membrane properties, in which we have used differential scanning calorimetry, X-ray diffraction, and FT-IR spectra, enables us to demonstrate that pseudo-ceramide with appropriate amounts of stearic acid and cholesterol can assemble to form a stable lamellar alpha-phase. Moreover, we show that cholesterol is indeed important and plays a role in controlling the melting entropy of lipid membranes, which is attributed to a disordered molecular packing, thus creating more flexible liposomal membranes. This approach to use pseudo-ceramide offers a useful means to fabricate a variety of biocompatible liposomes with controllable membrane properties, which enlarges their applicability in the field of drug delivery, dermatology, and cosmetics.
authors.affiliation: Amore-Pacific Co R&D Center, Yongin-si, Gyeonggi-Do 446-729, Republic of Korea.
authors.forename: Do-Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: An
authors.forename: Jongwon
authors.initials: J
authors.lastname: Kim
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Han
authors.forename: Jin-Woong
authors.initials: JW
authors.lastname: Kim
authors.forename: Seong-Geun
authors.initials: SG
authors.lastname: Oh
authors.forename: Kyung-Do
authors.initials: KD
authors.lastname: Suh
authors.forename: Eun Chul
authors.initials: EC
authors.lastname: Cho
mesh_terms: D002152:Calorimetry, Differential Scanning; D002518:Ceramides / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D002518:Ceramides; D008051:Lipid Bilayers; D008081:Liposomes