Primary vaginal extraosseous Ewing sarcoma/primitive neuroectodermal tumor with cranial metastasis.
Extraosseous Ewing sarcoma is now regarded as a member of the Ewing sarcoma/primitive neuroectodermal tumor (PNET) family. It typically involves the soft tissues of the chest wall, pelvis, paravertebral region, abdominal wall, retroperitoneal region and extremities of children, adolescents and young adults, but it seldom occurs in the female genital tract. We report an extremely rare case of retrospective diagnosis of vaginal extraosseous Ewing sarcoma/PNET which metastasized to the right frontoparietal scalp, skull, and dura. Surgical resection, followed by adjuvant radiotherapy and chemotherapy resulted in a favourable clinical outcome. Both the vaginal and head tumors had similar light microscopic features supporting the diagnosis.
Yip
Chi-Man
CM
Division of Neurosurgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C. yip_chiman@yahoo.com
Hsu
Shu-Shong
SS
Chang
Nai-Jen
NJ
Wang
Jyh-Seng
JS
Liao
Wei-Chuan
WC
Chen
Jun-Yih
JY
Liu
Su-Hao
SH
Chen
Chih-Hao
CH
D000071443:12E7 Antigen; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001932:Brain Neoplasms / Q000556:secondary*; D015815:Cell Adhesion Molecules / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis / Q000473:pathology*; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000473:pathology*
D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules