[Advance on pharmacologic actions, toxicity and pharmacokinetics of pyrrolizidine alkaloids].
Plants containing pyrrolizidine alkaloids were widely used in traditional medicine. Its hepatotoxicity is main toxicity as well known internationally. In order to providing some foundation for the future studies, the advancement on the pharmacologic actions, toxicity, and pharmacokinetics or toxicokinetics of pyrrolizidine alkaloids was reviewed.
Gao
Jiangguo
J
Department of Pharmaceutics and Physical Chemistry, College of Pharmacy of Xinjiang Medical University, Urumuqi 830054, China.
Wang
Changhong
C
Li
Yan
Y
Wang
Zhengtao
Z
D000818:Animals; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008099:Liver / Q000187:drug effects*; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry*; D011763:Pyrrolizidine Alkaloids / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000633:toxicity*
D010936:Plant Extracts; D011763:Pyrrolizidine Alkaloids