Antioxidative enzymes and increased oxidative stress in depressive women.
OBJECTIVE
To investigate the activities of the main antioxidative enzymes and oxidative stress in women with depressive disorder (DD).


METHODS
In 35 drug-naive women with DD and 35 age matched healthy women enzymes superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPX1), glutathione reductase (GR) and paraoxonase (PON1), concentrations of conjugated dienes (CD), reduced glutathione (GSH) and anthropometric and clinical data were investigated.


RESULTS
Women with DD were found to have decreased activities of GPX1 (p<0.05), decreased concentrations of GSH (p<0.05), and increased activities of GR (p<0.05), CuZnSOD (p<0.001), and concentrations of CD (p<0.05). Activity of GPX1 was positively correlated with concentration of GSH (p<0.05). Concentrations of CD were positively correlated with TG (p<0.01).


CONCLUSIONS
Our set of depressive women was characterized by changes indicating an increased oxidative stress, as well as by certain features of metabolic syndrome.
Kodydková
Jana
J
IV. Department of Internal Medicine, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic. jana.kodydkova@seznam.cz
Vávrová
Lucie
L
Zeman
Miroslav
M
Jirák
Roman
R
Macásek
Jaroslav
J
Stanková
Barbora
B
Tvrzická
Eva
E
Zák
Ales
A
D000368:Aged; D000466:Alkadienes / Q000097:blood / Q000737:chemistry; D043303:Aryldialkylphosphatase / Q000097:blood / Q000378:metabolism; D002374:Catalase / Q000097:blood / Q000378:metabolism; D003866:Depressive Disorder / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D004798:Enzymes / Q000097:blood / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D005980:Glutathione Reductase / Q000097:blood / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D000466:Alkadienes; D004798:Enzymes; D014280:Triglycerides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D005978:Glutathione