title: Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease.
abstract: Coronary artery disease (CAD) is based on the atherosclerosis of coronary artery and may manifest with myocardial infarction or angina pectoris. Although it is widely accepted that genetic factors are linked to CAD and several disease-related genes have been reported, only a few could be replicated suggesting that there might be some other CAD-related genes. To identify novel susceptibility loci for CAD, we used microsatellite markers in the screening and found six different candidate CAD loci. Subsequent single nucleotide polymorphism (SNP) association studies revealed an association between CAD and megakaryoblastic leukemia factor-1 gene (MKL1). The association with a promoter SNP of MKL1, -184C > T, was found in a Japanese population and the association was replicated in another Japanese population and a Korean population. Functional analysis of the MKL1 promoter SNP suggested that the higher MKL1 expression was associated with CAD. These findings suggest that MKL1 is involved in the pathogenesis of CAD.
authors.affiliation: Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hinohara
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakajima
authors.forename: Michio
authors.initials: M
authors.lastname: Yasunami
authors.forename: Shigeru
authors.initials: S
authors.lastname: Houda
authors.forename: Taishi
authors.initials: T
authors.lastname: Sasaoka
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Bok-Soo
authors.initials: BS
authors.lastname: Lee
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shibata
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Tanaka-Takahashi
authors.forename: Megumi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Takuro
authors.initials: T
authors.lastname: Arimura
authors.forename: Akinori
authors.initials: A
authors.lastname: Sato
authors.forename: Taeko
authors.initials: T
authors.lastname: Naruse
authors.forename: Jimin
authors.initials: J
authors.lastname: Ban
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Yamada
authors.forename: Motoji
authors.initials: M
authors.lastname: Sawabe
authors.forename: Jeong-Euy
authors.initials: JE
authors.lastname: Park
authors.forename: Toru
authors.initials: T
authors.lastname: Izumi
authors.forename: Akinori
authors.initials: A
authors.lastname: Kimura
mesh_terms: D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000378:metabolism; D016022:Case-Control Studies; D002478:Cells, Cultured; D003324:Coronary Artery Disease / Q000235:genetics* / Q000473:pathology; D017931:DNA Primers / Q000737:chemistry / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D004198:Disease Susceptibility; D005260:Female; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007564:Japan; D007723:Korea; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D015534:Trans-Activators
chemical_list: D017931:DNA Primers; D004268:DNA-Binding Proteins; C431575:MRTFA protein, human; D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger; D015534:Trans-Activators