title: Effect of lysosomotropic form of amphotericin B on functional state of phagocytes in experimental candidiasis.
abstract: Effect of antifungal preparation amphotericin B and its lysosomotropic composition with dialdehyde-dextran on functional state of phagocytizing cells in the dynamics of granulomatous inflammation induced by C. albicans was studied on CBA mice. A stimulating effect of amphotericin B on the production of reactive oxygen species by peritoneal and bone marrow phagocytes was observed, while lysosomotropic form of the antibiotic did not stimulate generation of oxygen radicals.
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Russia. medinfo@ngs.ru
authors.forename: V V
authors.initials: VV
authors.lastname: Kurilin
authors.forename: M A
authors.initials: MA
authors.lastname: Saperova
authors.forename: E A
authors.initials: EA
authors.lastname: Efanov
authors.forename: D D
authors.initials: DD
authors.lastname: Tsyrendorzhiev
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupiy
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D004195:Disease Models, Animal; D051379:Mice; D010586:Phagocytes / Q000187:drug effects* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D017382:Reactive Oxygen Species; D000666:Amphotericin B