Chronic immobilization stress induces anxiety- and depression-like behaviors and decreases transthyretin in the mouse cortex.
In this study, we examined the changes in gene expression in the mouse cortex following chronic stress and behavioral tests. Mice were subjected to immobilization stress for 2h per day for 15 consecutive days and the behavior of the mice was examined. The mice in the experimental group were more anxious and depressive than the control mice. The expression of mRNA in the cortex was analyzed by microarray analysis and 63 genes were found to show a greater than twofold change in expression between the control and experimental groups. Transthyretin was further investigated because its expression showed the greatest fold change. Transthyretin mRNA expression decreased in a chronic stress-specific manner, and protein levels were reduced in the cortex but not in the choroid plexus.
Joo
Yeon
Y
Department of Anatomy and Neurobiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, 92 Chilam-dong, Jinju 660-751, Republic of Korea.
Choi
Kyung Mi
KM
Lee
Young Hyurk
YH
Kim
Gyeongwha
G
Lee
Dong Hoon
DH
Roh
Gu Seob
GS
Kang
Sang Soo
SS
Cho
Gyeong Jae
GJ
Choi
Wan Sung
WS
Kim
Hyun Joon
HJ
D000818:Animals; D001007:Anxiety / Q000209:etiology* / Q000378:metabolism / Q000523:psychology; D001522:Behavior, Animal; D002540:Cerebral Cortex / Q000378:metabolism*; D002908:Chronic Disease; D003863:Depression / Q000209:etiology* / Q000378:metabolism / Q000523:psychology; D055106:Genome-Wide Association Study; D007103:Immobilization; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011228:Prealbumin / Q000378:metabolism*; D013315:Stress, Psychological / Q000150:complications*
D011228:Prealbumin