title: Radiation-induced cavernous hemangiomas: case report and literature review.
abstract: The case of a 51-year-old man diagnosed with two acquired cavernous hemangiomas 17 years after cranial irradiation for a cerebellar astrocytoma is reported. A review of 84 cases of radiation-induced cavernous hemangiomas found in the literature is presented. In this series the mean age at the time of irradiation (+/- SD) was 10.4 +/- 2.0 years (median = 8 years), while the mean time to cavernous hemangioma diagnosis (+/- SD) was 10.3 +/- 1.9 years (median = 8 years). Time to cavernous hemangioma diagnosis was found to be inversely related to radiation dose. Hemorrhage from radiation-induced cavernous hemangiomas was found in 40.0% of patients, with an incidence of 3.9% per patient year. An inverse trend was identified between radiation dose and symptomatic presentation, cavernous hemangioma hemorrhage or surgical resection. This review of radiation-induced cavernous hemangiomas confirms that both younger patients and those who received a larger dose of radiation are at increased risk of radiation-induced cavernous hemangiomas. Our results suggest that, based on an assessment of CT or MR images, there may be an increased risk of hemorrhage when comparing radiation-induced to congenital cavernous hemangiomas. Increasing radiation doses appear to stabilize these lesions, decreasing the risk of a symptomatic presentation, cavernous hemangioma hemorrhage and surgical intervention.
authors.affiliation: Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada.
authors.forename: Mark Robert
authors.initials: MR
authors.lastname: Keezer
authors.forename: Rolando
authors.initials: R
authors.lastname: Del Maestro
mesh_terms: D016371:Cranial Irradiation / Q000009:adverse effects*; D006392:Hemangioma, Cavernous / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged