title: 7-ketocholesterol induces endoplasmic reticulum stress in HT-29 cells.
abstract: 7-Ketocholesterol (7-Kchol, oxidized cholesterol) is an important mediator of cell death in atherosclerosis mediated by up-regulated Nox 4 gene expression. In the current study using the human colon cancer HT-29 cell line, we have demonstrated that 7-Kchol promotes endoplasmic reticulum (ER) stress via gene up-regulation of ER chaperone and membrane kinases.
authors.affiliation: Department of Pathology, Chungnam National University, College of Medicine, Taejon 301-747, Korea.
authors.forename: Won-Hyo
authors.initials: WH
authors.lastname: Lee
authors.forename: Choong Sik
authors.initials: CS
authors.lastname: Lee
authors.forename: Kisang
authors.initials: K
authors.lastname: Kwon
authors.forename: Young-Sook
authors.initials: YS
authors.lastname: Kwon
authors.forename: Seung-Whan
authors.initials: SW
authors.lastname: Kim
authors.forename: Tae-Won
authors.initials: TW
authors.lastname: Goo
authors.forename: O-Yu
authors.initials: OY
authors.lastname: Kwon
mesh_terms: D045744:Cell Line, Tumor; D003110:Colonic Neoplasms; D017931:DNA Primers; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000502:physiology*; D019073:HT29 Cells / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007653:Ketocholesterols / Q000494:pharmacology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D017931:DNA Primers; D007653:Ketocholesterols; C003001:7-ketocholesterol