title: Novel application of plasma treatment for pharmaceutical and biomedical engineering.
abstract: The nature of plasma-induced surface radicals formed on a variety of organic polymers has been studied by electron spin resonance (ESR), making it possible to provide a sound basis for future experimental design of polymer surface processing using plasma treatment. On the basis of the findings from such studies, several novel bio-applications in the field of drug- and biomedical- engineering have been developed. Applications for drug engineering include the preparation of reservoir-type drug delivery system (DDS) of sustained- and delayed-release, and floating drug delivery system (FDDS) possessing gastric retention capabilities, followed by preparation of "Patient-Tailored DDS". Furthermore, the preparation of composite powders applicable to matrix-type DDS was developed by making a mechanical application to the surface radical-containing polymer powders with drug powders. In applications for biomedical engineering, the novel method to introduce the durable surface hydrophilicity and lubricity on hydrophobic biomedical polymers was developed by plasma-assisted immobilization of carboxyl group-containing polymer on the polymer substrate. The surfaces thus prepared were further used for the covalent immobilization of oligo-nucleotides (DNA) onto the polymer surfaces applicable to constructing DNA diagnosis system, and also plasma-assisted preparation of functionalized chemo-embolic agent of vinyl alcohol-sodium acrylate copolymer (PVA- PAANa).
authors.affiliation: Department of Pharmaceutical Physical Chemistry, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. mkuzuya@cc.matsuyama-u.ac.jp; kuzuya@gifu-pu.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kuzuya
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sasai
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Kondo
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Yamauchi
mesh_terms: D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004355:Drug Stability; D004583:Electrons; D005609:Free Radicals / Q000737:chemistry; D006801:Humans; D007477:Ions; D005741:Noble Gases; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D005609:Free Radicals; D007477:Ions; D005741:Noble Gases; D004364:Pharmaceutical Preparations; D011108:Polymers; D013607:Tablets