Inhibitory effects of morinda officinalis extract on bone loss in ovariectomized rats.
The present study was undertaken to investigate the protective effects of ethanol extract from the root of Morinda Officinalis (RMO) on ovariectomy-induced bone loss. Administration of RMO extract increased trabecular bone mineral content and bone mineral density of tibia, improved the levels of phosphorus (P), calcium (Ca) and OPG, decreased the levels of DPD/Cr, TRAP, ACTH and corticosterone, but did not reverse the levels of ALP, TNF-alpha and IL-6 in serum of ovariectomized rats. These findings demonstrated that RMO extract reduced bone loss in ovariectomized rats, probably via the inhibition of bone resorption, but was not involved with bone formation. Anthraquinones and polysaccharides from Morinda officinals could be responsible for their antiosteoporotic activity, and the action mechanism of these constituents needs to be further studied. Therefore, RMO has the potential to develop a clinically useful antiosteoporotic agent.
Li
Nan
N
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Qin
Lu-Ping
LP
Han
Ting
T
Wu
Yan-Bin
YB
Zhang
Qiao-Yan
QY
Zhang
Hong
H
D000135:Acid Phosphatase / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003345:Corticosterone / Q000097:blood; D005260:Female; D015850:Interleukin-6 / Q000097:blood; D007527:Isoenzymes / Q000097:blood; D015394:Molecular Structure; D032066:Morinda / Q000737:chemistry*; D009929:Organ Size / Q000187:drug effects; D053244:Osteoprotegerin / Q000097:blood; D010052:Ovariectomy; D010758:Phosphorus / Q000097:blood; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000071681:Tartrate-Resistant Acid Phosphatase; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015850:Interleukin-6; D007527:Isoenzymes; D053244:Osteoprotegerin; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D010758:Phosphorus; D000324:Adrenocorticotropic Hormone; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D002118:Calcium; D003345:Corticosterone