title: Endoscopic gallbladder drainage for acute cholecystitis: technical and clinical results.
abstract: OBJECTIVE
  Cholecystectomy is the standard treatment for acute cholecystitis while percutaneous drainage is reserved for high-risk patients. The aim of the present study was to assess the technical success rate and clinical efficacy of endoscopic gallbladder drainage in patients with acute cholecystitis.
  
  
  METHODS
  A total of 35 consecutive patients with acute cholecystitis and without residual common bile duct obstruction were retrospectively identified. Patients were stratified according to the pathogenesis and stages of acute cholecystitis, and the morphology of the cystic duct and/or its insertion in the common bile duct. Primary outcomes were technical success and early and late clinical success.
  
  
  RESULTS
  Endoscopic retrograde cholangiopancreatography (ERCP) was performed within the first 72 hours in 19 patients (54%). Technical success was achieved in 29 patients (83%); drainage was nasocholecystic in 21 of these (72%), plastic stenting in 6 (21%), and a combined method in 2 (7%). The pathogenesis and stage of acute cholecystitis, and the morphology both of the cystic duct and its insertion in the common bile duct, did not influence technical success. Clinical success was achieved in 24 cases (83%) after a median of 3 days (range 2-12). Four patients (14%) died within 3 days due to septic complications, and one accidentally removed the nasocholecystic drain after 24 hours. Late results, available in 21 patients after a median follow-up of 17 months, showed relapse of acute cholecystitis in 2 (10%) (both with stents) and of biliary pain in 2 patients (10%), both of whom had nasocholecystic drainage.
  
  
  CONCLUSIONS
  Endoscopic gallbladder drainage seems feasible and effective in resolving acute cholecystitis, but only as a temporary measure because of a 20% relapse rate in long-term follow-up. Prospective studies are necessary to identify which patients would benefit most from this endoscopic technique in the short and long term.
authors.affiliation: Digestive Endoscopy Unit, Department of Surgery, Università Cattolica A. Gemelli, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mutignani
authors.forename: F
authors.initials: F
authors.lastname: Iacopini
authors.forename: V
authors.initials: V
authors.lastname: Perri
authors.forename: P
authors.initials: P
authors.lastname: Familiari
authors.forename: A
authors.initials: A
authors.lastname: Tringali
authors.forename: C
authors.initials: C
authors.lastname: Spada
authors.forename: M
authors.initials: M
authors.lastname: Ingrosso
authors.forename: G
authors.initials: G
authors.lastname: Costamagna
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002760:Cholangiopancreatography, Endoscopic Retrograde; D041881:Cholecystitis, Acute / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome