Ammonificins A and B, hydroxyethylamine chroman derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans.
Two hydroxyethylamine chroman derivatives, ammonificins A (1) and B (2), were isolated from the marine hydrothermal vent bacterium Thermovibrio ammonificans. The molecular structures of these compounds were determined using a combination of NMR, mass spectrometry, and CD analyses. Biological activities were determined using an antimicrobial assay and the patented ApopScreen cell-based screen for apoptosis induction and potential anticancer activity. To our knowledge, this is the first report of secondary metabolites from the marine hydrothermal vent bacterium T. ammonificans.
Andrianasolo
Eric H
EH
Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Jersey 08901-8521, USA.
Haramaty
Liti
L
Rosario-Passapera
Richard
R
Bidle
Kelly
K
White
Eileen
E
Vetriani
Costantino
C
Falkowski
Paul
P
Lutz
Richard
R
D017209:Apoptosis; D001419:Bacteria / Q000737:chemistry*; D002839:Chromans / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D002839:Chromans; C542222:ammonificin A; C542221:ammonificin B