title: [The effect of preoperative administration of heparin on the heparin resistance development].
abstract: BACKGROUND
  Heparin resistance is relatively frequent problem in cardio surgery. We were try to determine real occurrence heparin resistance before operation.
  
  
  OBJECTIVE
  Purpose of the project--to find the real frequency of heparin resistance in patients who will undergo a cardio surgical operation. To find out the dependence between the pre-operational application of heparin and the development of heparin resistance.
  
  
  METHODS
  We recorded pre-operative administration heparin in patients. If the dose of heparin was 5 mg/kg and more then we insert patients to the group heparin resistant.
  
  
  RESULTS
  In our collection was heparin resistance in 203 patients from 624, it was 32.5%. Test agreement relative frequency with 22% was throw out--p < 0.001--heparin resistance in our group statistically different from 22% heparin resistance was higher than hypothesis. Heparin before operation was administrate 181 patients, which make to 29%. For administration of heparin was hypothesis of independence thrown (p < 0.001).
  
  
  CONCLUSIONS
  Results of our works confirmed statistically significant occurrence of heparin resistance in patients that was administration heparin pre-operative. Heparin resistance occurred against presumption 22% in 32.5% in our group. It is statistic significant difference.
authors.affiliation: Kardiochirurgická klinika FN a LF UK Hradec Králové. vbrzek@seznam.cz
authors.forename: V
authors.initials: V
authors.lastname: Brzek
authors.forename: V
authors.initials: V
authors.lastname: Lonský
authors.forename: S
authors.initials: S
authors.lastname: Jiska
authors.forename: J
authors.initials: J
authors.lastname: Kubícek
authors.forename: D
authors.initials: D
authors.lastname: Nováková
authors.forename: P
authors.initials: P
authors.lastname: Valentová
authors.forename: J
authors.initials: J
authors.lastname: Bímová
authors.forename: M
authors.initials: M
authors.lastname: Volt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D004351:Drug Resistance; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D011300:Preoperative Care
chemical_list: D000925:Anticoagulants; D006493:Heparin