title: Cost-effectiveness of pneumococcal polysaccharide vaccination in adults: a systematic review of conclusions and assumptions.
abstract: Streptococcus pneumoniae infections in adults are associated with substantial morbidity, mortality, and costs. A literature review was conducted to identify strengths and limitations of the cost-effectiveness of pneumococcal polysaccharide vaccine studies. A comparative analysis of the impact of model parameters on cost-effectiveness ratios was complemented by systematic assessment of the studies. We identified 11 economic evaluations of pneumococcal polysaccharide vaccine (PPV-23) in adults. In general, all 11 studies found that vaccination with PPV-23 is a cost-effective, and in some cases a cost-saving strategy for the prevention of invasive pneumococcal disease (IPD). The systematic assessment indicated that the results of the cost-effectiveness studies of PPV-23 are influenced by the values applied to vaccine efficacy, IPD incidence and case-fatality.
authors.affiliation: BioMedCom Consultants inc., 1405 TransCanada Highway, Suite 310, Montreal, Quebec, Canada H9P 2V9.
authors.forename: Isla
authors.initials: I
authors.lastname: Ogilvie
authors.forename: Antoine El
authors.initials: AE
authors.lastname: Khoury
authors.forename: Yadong
authors.initials: Y
authors.lastname: Cui
authors.forename: Erik
authors.initials: E
authors.lastname: Dasbach
authors.forename: John D
authors.initials: JD
authors.lastname: Grabenstein
authors.forename: Mireille
authors.initials: M
authors.lastname: Goetghebeur
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003362:Cost-Benefit Analysis; D006801:Humans; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000191:economics* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000191:economics* / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination / Q000191:economics*
chemical_list: C414006:23-valent pneumococcal capsular polysaccharide vaccine; D022242:Pneumococcal Vaccines