title: Expression of serotonin transporter gene and startle response in rats with genetically determined fear-induced aggression.
abstract: The study was carried out on Norway rats selected through more than 60 generations for high and low fear-induced aggressiveness towards humans (Institute of Cytology and Genetics). The intensity of aggressive behavior towards man, reflex startle response, and expression of serotonin transporter (5-HTT) gene were studied. Selection for high aggression was associated with more intense startle response. The expression of 5-HTT gene in the frontal cortex was reduced significantly in rats selected for high aggression to humans in comparison with nonaggressive rats. The authors conclude that 5-HTT is involved in the regulation of genetically determined fear-induced aggression.
authors.affiliation: Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia. naumenko2002@mail.ru
authors.forename: V S
authors.initials: VS
authors.lastname: Naumenko
authors.forename: R V
authors.initials: RV
authors.lastname: Kozhemjakina
authors.forename: I Z
authors.initials: IZ
authors.lastname: Plyusnina
authors.forename: N K
authors.initials: NK
authors.lastname: Popova
mesh_terms: D000374:Aggression; D000818:Animals; D005239:Fear; D051381:Rats; D013216:Reflex, Startle / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins