title: Intraoperative autologous transfusion of hemolyzed blood.
abstract: During two cases of lumbar spine surgery with instrumentation, we used intraoperative autologous transfusion (IAT), resulting in hemolysis during collection and hemoglobinuria and coagulation abnormalities after transfusion. Hemolysis during IAT collection can lead to hemoglobinuria and binding of nitric oxide, leading to vasoconstriction. The literature suggests that stroma from damaged cells and contact of the blood with the IAT device can lead to coagulation abnormalities and other morbidities, including adult respiratory distress syndrome.
authors.affiliation: Department of Anesthesiology, University of Colorado at Denver and Health Sciences Center, Anschutz Office West (AO1), PO Box 6511, 12631 E 17th Ave., Aurora, CO 80045, USA. tod.sloan@ucdenver.edu
authors.forename: Tod B
authors.initials: TB
authors.lastname: Sloan
authors.forename: Greg
authors.initials: G
authors.lastname: Myers
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Janik
authors.forename: Evalina M
authors.initials: EM
authors.lastname: Burger
authors.forename: Vikas V
authors.initials: VV
authors.lastname: Patel
authors.forename: Leslie C
authors.initials: LC
authors.lastname: Jameson
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control; D001804:Blood Transfusion, Autologous / Q000379:methods*; D005260:Female; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D008297:Male; D008875:Middle Aged