title: Synthesis, in-vitro microbial and cytotoxic studies of new benzimidazole derivatives.
abstract: Several new classes of benzimidazole derivatives were synthesized and evaluated for in-vitro antimicrobial and cytotoxic activities. The results showed that all synthesized compounds exhibited moderate antimicrobial activity, and compounds 2, 4, and 13 displayed cytotoxic activity (as LD(50)) at the concentration 1 x 10(-3) M against Artemia salina.
authors.affiliation: P. G. Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad, India.
authors.forename: Reddy S
authors.initials: RS
authors.lastname: Harisha
authors.forename: Kallappa M
authors.initials: KM
authors.lastname: Hosamani
authors.forename: Rangappa S
authors.initials: RS
authors.lastname: Keri
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001156:Artemia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D005658:Fungi / Q000187:drug effects; D066298:In Vitro Techniques; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000890:Anti-Infective Agents; D001562:Benzimidazoles