title: Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.
abstract: Phosphorylated tau (p-tau) is the principal component of neurofibrillary tangles, a pathological hallmark, and likely plays a neurotoxic role in tauopathies including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). We subjected brains from autopsy cases of AD, PSP, and CBD to a variety of immunohistochemical, immunoblotting, and pull-down assays. In this study, we show that excitatory amino acid transporter 2 (EAAT2) preferentially interacted with phosphorylated tau and was localized in neurofibrillary tangles in the brains of such patients. These results strongly indicate that EAAT2 acts in tauopathy-related neurodegeneration, and abnormalities in glutamate transport play an important role in the pathogenesis of tauopathies.
authors.affiliation: Department of Neurology, Juntendo University, Urayasu Hospital, Tokyo, Japan.
authors.forename: Kumi
authors.initials: K
authors.lastname: Sasaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Shimura
authors.forename: Masako
authors.initials: M
authors.lastname: Itaya
authors.forename: Ryota
authors.initials: R
authors.lastname: Tanaka
authors.forename: Hideo
authors.initials: H
authors.lastname: Mori
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kosik
authors.forename: Shigeki
authors.initials: S
authors.lastname: Tanaka
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D027342:Excitatory Amino Acid Transporter 2 / Q000032:analysis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D024801:Tauopathies / Q000378:metabolism* / Q000473:pathology; D016875:tau Proteins / Q000032:analysis / Q000378:metabolism*
chemical_list: D027342:Excitatory Amino Acid Transporter 2; D016875:tau Proteins