Development of a modular system for the synthesis of PET [(11)C]labelled radiopharmaceuticals.
[((11))C]labelled radiopharmaceuticals as N-[(11)C]methyl-choline ([(11)C]choline), l-(S-methyl-[(11)C])methionine ([(11)C]methionine) and [(11)C]acetate have gained increasing importance in clinical PET and for the routine production of these radiopharmaceuticals, simple and reliable modules are needed to produce clinically relevant radioactivity. On the other hand, flexible devices are needed not only for the routine synthesis but also for more complex applications as the development of new tracers. The aim of this work was the adaptation of an Eckert Ziegler modular system for easy routine synthesis of [(11)C]choline, [(11)C]methionine and [(11)C]acetate using components that account for straightforward scaling up and upgrades.
Boschi
Stefano
S
PET Radiopharmacy, Nuclear Medicine, Azienda Ospedaliero Universitaria di Bologna, Policlinico S.Orsola-Malpighi, Bologna, Italy. stefano.boschi@aosp.bo.it
Lodi
Filippo
F
Cicoria
Gianfranco
G
Raul Ledesma
Jorge
J
Knopp
Roger
R
Rizzello
Anna
A
Di Pierro
Donato
D
Trespidi
Silvia
S
Marengo
Mario
M
D000085:Acetates / Q000737:chemistry; D002250:Carbon Radioisotopes; D002794:Choline / Q000138:chemical synthesis; D007553:Isotope Labeling / Q000295:instrumentation*; D008715:Methionine / Q000138:chemical synthesis; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D000085:Acetates; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D008715:Methionine; D002794:Choline