title: [Effect of tongmal recipe on atherosclerosis in patients with early lower extremity arteriopathy caused by type 2 diabetes mellitus].
abstract: OBJECTIVE
  To observe the effect of Tongmai Recipe (TMR) on atherosclerosis (AS) in patients with early lower extremity arteriopathy disease (LEAD) caused by type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  Patients were randomly assigned to two groups. The 23 patients in the treatment group were treated by TMR and the 22 in the control group were given Cilostazo, all for 3 months. Before and after treatment, lower extremity vascular color Doppler image, blood levels of glucose, insulin, serum matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) were measured.
  
  
  RESULTS
  The thickness of AS plaque and that of arterial intima-media obviously reduced (P < 0.01 and P < 0.05), insulin sensitivity improved noticeably (P < 0.01), and serum levels of MMP-9 and IL-6 lowered obviously (P < 0.05) in the treatment group after treatment, but these indexes were unchanged in the control group statistically.
  
  
  CONCLUSIONS
  TMR has remarkable action in reducing the thickness of AS plaque and intima-media of artery, its mechanism might be related with improving of insulin sensitivity and anti-inflammatory reaction, and reducing of serum MMP-9 level as well in patients.
authors.affiliation: Institute of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai. zgl3333@sohu.com
authors.forename: Guang-Liang
authors.initials: GL
authors.lastname: Zuo
authors.forename: Jian-Qiu
authors.initials: JQ
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D008517:Phytotherapy; D016909:Tibial Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography
chemical_list: D004365:Drugs, Chinese Herbal; C508600:IL6 protein, human; D015850:Interleukin-6; D020780:Matrix Metalloproteinase 9