title: Contact-active microbicidal gold surfaces using immobilization of quaternary ammonium thiol derivatives.
abstract: Contact-active auto-bactericidal surfaces were obtained by grafting of specially designed thiol derivatives containing antimicrobial quaternary ammonium moieties on gold substrates. The formation and quality of the self-assembled monolayers (SAMs) were characterized by X-ray photoelectron spectroscopy, cyclic voltammetry and contact angle measurements. The bactericidal activity of the modified gold surface was evaluated against Staphylococcus aureus using an original procedure. This activity was demonstrated to be dependent on the length of the alkyl chain borne by the charged nitrogen atom of the quaternary ammonium moiety, and on the contact time.
authors.affiliation: Université de Nice-Sophia Antipolis, Laboratoire de Chimie des Matériaux Organiques et Métalliques, Institut de Chimie de Nice, Equipe Chimie Organique aux Interfaces, Parc Valrose, 06108 Nice Cedex 2, France. Pascal.Thebault@unice.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Thebault
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Taffin de Givenchy
authors.forename: Richard
authors.initials: R
authors.lastname: Levy
authors.forename: Yves
authors.initials: Y
authors.lastname: Vandenberghe
authors.forename: Frédéric
authors.initials: F
authors.lastname: Guittard
authors.forename: Serge
authors.initials: S
authors.lastname: Géribaldi
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D055664:Electrochemical Techniques; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D000890:Anti-Infective Agents; D000644:Quaternary Ammonium Compounds; D013438:Sulfhydryl Compounds; D006046:Gold