title: PLZF outreach: a finger in interferon's pie.
abstract: In this issue of Immunity, Xu et al. (2009) find that the transcription factor PLZF activates interferon-stimulated genes and facilitates natural killer cell functions. Interferon-induced PLZF phosphorylation and histone deacetylase 1 recruitment probably mediates the repressor-to-activator conversion.
authors.affiliation: Program on Genomics in Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. ozatok@nih.gov
authors.forename: Keiko
authors.initials: K
authors.lastname: Ozato
mesh_terms: D000818:Animals; D006655:Histone Deacetylases / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D007372:Interferons / Q000276:immunology / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000276:immunology; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism*; D000075722:Promyelocytic Leukemia Zinc Finger Protein; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D051741:Kruppel-Like Transcription Factors; D000075722:Promyelocytic Leukemia Zinc Finger Protein; D012097:Repressor Proteins; C513267:Zbtb16 protein, mouse; C092037:ZBTB16 protein, human; D007372:Interferons; D006655:Histone Deacetylases