[Genomic technologies in medicine].
Genomic analysis on genetic variation, e.g. SNPs and CNVs, have revealed the phenotype-genotype association for various diseases. Furthermore, recent progress in high throughput sequencing technology should have a great impact in elucidating both genetic and epigenetic mechanisms of human diseases. Several ongoing genome sequencing projects will provide the fundamental information to realize the personalized medicine in next few years. Integration of genomic and clinical information will be crucial to develop biomarkers for early diagnostics and treatment selection.
Aburatani
Hiroyuki
H
Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo.
D018628:Gene Dosage; D030342:Genetic Diseases, Inborn / Q000175:diagnosis; D023281:Genomics / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide