[Effect of Stimforte in combination with Virazole on infection induced by hepatitis C virus in mice].
Twenty-four hours after intramuscular injection of Stimforte in a dose of 25 microg in mice weighing 18-20 g, chronically infected with hepatitis C virus (HCV), viral infection was shown to be at the most suppressed viral replication, as suggested by the data of the infectious and antigenic activities of HCV. Following 72 hours of its administration, the quantity of viral antigen and the infectious activity restored. Readministration of the agent considerably suppressed HCV replication. When given in a dose of 12.5 microg/kg, the agent reduced HCV titers by 2.0-2.5 log10 TCID50; when used in a dose of 25 microg/kg, it diminished the infectious activity of HCV by 3.2 log. The similar data were obtained in the study of the antigenic activity of HCV in infected animals. The effect of Virazole in combination with Stimforte in reducing the replication of infectious HCV and the accumulation of antigens in HCV-infected mice was additive or synergic, suggesting that it is expedient to use them concurrently.
Mal'dov
D G
DG
Deriabin
P G
PG
Il'ichev
A V
AV
Bel'kov
A P
AP
Isaeva
E I
EI
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D016174:Hepacivirus / Q000187:drug effects* / Q000502:physiology; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology; D007155:Immunologic Factors / Q000008:administration & dosage*; D007273:Injections, Intramuscular; D051379:Mice; D012254:Ribavirin / Q000008:administration & dosage*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D007155:Immunologic Factors; D012254:Ribavirin