Simulation of unilateral ischemic injury to the striatal neurons inflicted by short-term occlusion of the middle cerebral artery.
The reproducibility of brain injury was evaluated by simulating ischemia in rats by 30-min occlusion of the middle cerebral artery. The selected ischemia-reperfusion protocol was characterized by high reproduction of the striatal neuron injury, which fact suggests this model for studies of nerve tissue reactions to injury and for evaluation of the efficiency of neuroprotective drugs.
Korzhevskii
D E
DE
Department of Common and Special Morphology, Institute of Experimental Medicine, the Russian Academy of Medical Sciences, St Petersburg, Russia. dek2@yandex.ru
Kirik
O V
OV
Baisa
A E
AE
Vlasov
T D
TD
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology* / Q000378:metabolism; D007150:Immunohistochemistry; D020244:Infarction, Middle Cerebral Artery / Q000150:complications*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000209:etiology* / Q000378:metabolism
D009419:Nerve Tissue Proteins