title: Influence of black cohosh (Cimicifuga racemosa) use by postmenopausal women on total hepatic perfusion and liver functions.
abstract: In this prospective longitudinal clinical trial, 87 postmenopausal women receiving for 12 consecutive months a daily dose of 40 mg of a dry extract preparation of Cimicifuga racemosa (Klimadynon) for relief of vasomotor symptoms were followed up by evaluation of total hepatic blood flow, assessed by color Doppler ultrasound, as well as prothrombin time and concentration, serum albumin, bilirubin, gamma-glutamyltransferase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase. Because no significant changes in total hepatic blood flow or any of the liver functions tested were reported, we concluded that use of C. racemosa for 1 year by healthy postmenopausal women without evidence of liver disease does not seem to influence the liver.
authors.affiliation: Department of Obstetrics and Gynecology, Women's Health Center, Assiut, Egypt. a_nasr02@lycos.com
authors.forename: Ahmed
authors.initials: A
authors.lastname: Nasr
authors.forename: Hanan
authors.initials: H
authors.lastname: Nafeh
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D031885:Cimicifuga / Q000737:chemistry; D005260:Female; D005500:Follow-Up Studies; D019584:Hot Flashes / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D008102:Liver Circulation / Q000187:drug effects*; D008875:Middle Aged; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D017698:Postmenopause / Q000187:drug effects* / Q000502:physiology; D015995:Prevalence; D018615:Ultrasonography, Doppler, Color; D014666:Vasomotor System / Q000187:drug effects
chemical_list: D010936:Plant Extracts