Subacute toxicological evaluation of Asiasari radix methanol extract.
Asiasari radix, a traditional herbal medicine commonly used to treat various diseases, currently has a lack of information about adverse effects. Safety information of A. radix and its extract is limited to its historical use. The safety of A. radix methanol extract was tested in an oral subacute 28-day toxicity study in both male and female Sprague-Dawley (SD) rats at doses of 50, 250, and 500 mg/kg/day. No mortality and significant signs of toxicity were observed in either the control or treated groups of both sexes. There were no significant differences in the body and organ weights or in food and water consumption. Hematological and biochemical parameters showed no changes in either the control or treated groups of both sexes. Pathologically, neither gross abnormalities nor histopathological changes were observed. Therefore, methanolic extract of A. radix appears to be safe and nontoxic in these studies, and a no observed adverse effect level in rats is established at 500 mg/kg/day, the highest dose tested.
Ramesh
Thiyagarajan
T
Department of Pharmacology and Metabolic Diseases Research Laboratory, School of Dentistry, Kyung Hee University, Seoul, Korea.
Lee
Keun
K
Lee
Hyeon-Woo
HW
Kim
Sung-Jin
SJ
D000284:Administration, Oral; D000818:Animals; D029065:Aristolochiaceae / Q000737:chemistry / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D019963:Clinical Chemistry Tests; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D005260:Female; D006403:Hematologic Tests; D008297:Male; D000432:Methanol / Q000737:chemistry; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D000432:Methanol