title: Moderate hypobaric hypoxia modifies Ca2+-mediated glutamatergic signal transduction in rat cerebral cortex.
abstract: Examination of fluorescent Ca(2+)-responses to stimulation by ionotropic glutamate receptor agonists in rat cerebral cortex slices, preconditioned with hypobaric hypoxia, has demonstrated different time course for up-regulation of their Ca(2+)-conductivity and for stimulation of the consequent binding of the Ca(2+) which entered the cell. The evident result is the development of AMPA-mediated moderate increase of intracellular Ca(2+).
authors.affiliation: Pavlov Institute of Physiology of Russian Academy of Sciences, Saint-Petersburg. dsem50@rambler.ru
authors.forename: D G
authors.initials: DG
authors.lastname: Semenov
authors.forename: A V
authors.initials: AV
authors.lastname: Belyakov
authors.forename: M O
authors.initials: MO
authors.lastname: Samoilov
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
chemical_list: D018690:Excitatory Amino Acid Agonists; D018698:Glutamic Acid; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D002118:Calcium