"Dropped head syndrome" caused by Lambert-Eaton myasthenic syndrome.
A 67-year-old man was admitted with a 2-year history of dropped head. Neurological examination revealed ptosis, dysarthria, neck weakness, hyporeflexia of all limbs, and autonomic failure. Electrophysiologic study showed a 400% increment response to high-rate repetitive nerve stimulation. Serum anti-P/Q-voltage-gated calcium channel antibody was positive, confirming the diagnosis of Lambert-Eaton myasthenic syndrome (LEMS). His symptoms and electrophysiological abnormalities improved with oral prednisolone following plasmapheresis. This is the first report of LEMS as a cause of dropped head syndrome.
Ueda
T
T
Department of Neurology, Kobe University Hospital, Kobe, Japan. taueda@med.kobe-u.ac.jp
Kanda
F
F
Kobessho
H
H
Hamaguchi
H
H
Motomura
M
M
D000368:Aged; D019416:Head Movements; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications* / Q000473:pathology; D008297:Male; D009069:Movement Disorders / Q000209:etiology* / Q000473:pathology