Postpartum-acquired haemophilia A: a description of three cases and literature review.
Postpartum-acquired haemophilia A is a rare but potentially severe complication of pregnancy. Although the natural history of the disease is usually benign, with a high percentage of spontaneous remissions and a low mortality, its quick recognition is important to control bleeding episodes. The therapeutic strategies in these patients are the treatment of acute bleeding episodes and the long-term eradication of the autoantibody. We report three different cases of postpartum-acquired haemophilia demonstrating the broad heterogeneity of the clinical presentation and of therapeutic necessity of this condition. Finally, we present a review of the literature on the current therapeutic management of this haemorrhagic disorder.
Santoro
Rita C
RC
Haemophilia Center, Haemostasis and Thrombosis Service, Oncology and Haematology Department, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy. ritasant@interfree.it
Prejanò
Simona
S
D000328:Adult; D000740:Anemia / Q000209:etiology / Q000628:therapy; D001323:Autoantibodies / Q000096:biosynthesis / Q000276:immunology*; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D003475:Curettage; D004438:Ecchymosis / Q000188:drug therapy / Q000209:etiology; D005169:Factor VIII / Q000276:immunology*; D015942:Factor VIIa / Q000627:therapeutic use; D005260:Female; D006406:Hematoma / Q000188:drug therapy / Q000209:etiology / Q000628:therapy; D006467:Hemophilia A / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007231:Infant, Newborn; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D011644:Puerperal Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use; D014592:Uterine Hemorrhage / Q000188:drug therapy / Q000209:etiology / Q000628:therapy; D055815:Young Adult
D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D011994:Recombinant Proteins; C078147:F8 protein, human; D005169:Factor VIII; C103587:recombinant FVIIa; D015942:Factor VIIa; D011241:Prednisone