title: GnRH analogue treatment before hysteroscopic resection of submucous myomas: a prospective, randomized, multicenter study.
abstract: OBJECTIVE
  To evaluate the efficacy of GnRH analogue treatment before hysteroscopic resection of submucous myomas in patients with abnormal uterine bleeding.
  
  
  METHODS
  Multicenter, prospective, randomized, clinical study.
  
  
  METHODS
  Tertiary-care university hospitals.
  
  
  METHODS
  Thirty-nine consecutive patients with submucous myomas graded as G0 or G1 according to the European Society for Gynecological Endoscopy classification (myoma size 10-35 mm).
  
  
  METHODS
  Patients were randomized to either direct surgery or 2 months of GnRH analogues before undergoing hysteroscopic resection of the submucous myoma.
  
  
  METHODS
  Operating times, fluid absorption, difficulty of the operation, surgeon satisfaction with the procedure, intra- and postoperative complications, postoperative pain, and patient satisfaction were recorded.
  
  
  RESULTS
  Patients treated with GnRH analogue had significantly shorter operative times (15.9+/-3.1 minutes vs. 21.3+/-4.0 minutes) and significantly reduced fluid absorption (378+/-137 mL vs. 566+/-199 mL) compared with no preoperative medical treatment. Operative difficulty and overall surgeon satisfaction were significantly better in the GnRH analogue group. Patient satisfaction was similar in the two groups.
  
  
  CONCLUSIONS
  GnRH analogue treatment before hysteroscopic resection of G0-G1 10-35 mm submucous myomas was effective in reducing operative times, fluid absorption, and difficulty of the procedure.
authors.affiliation: Department of Obstetrics and Gynecology, Campus Bio-Medico University, Rome, Italy. Electronic address: l.muzii@unicampus.it.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Muzii
authors.affiliation: Department of Obstetrics and Gynecology, "Sapienza" University, Rome, Italy.
authors.forename: Terenzio
authors.initials: T
authors.lastname: Boni
authors.affiliation: Department of Obstetrics and Gynecology, "Sapienza" University, Rome, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Bellati
authors.affiliation: Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart and International Scientific Institute "Paolo VI," Rome, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Marana
authors.affiliation: Department of Obstetrics and Gynecology, Campus Bio-Medico University, Rome, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Ruggiero
authors.affiliation: Department of Obstetrics and Gynecology, Campus Bio-Medico University, Rome, Italy.
authors.forename: Marzio A
authors.initials: MA
authors.lastname: Zullo
authors.affiliation: Department of Obstetrics and Gynecology, Campus Bio-Medico University, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Angioli
authors.affiliation: Department of Obstetrics and Gynecology, "Sapienza" University, Rome, Italy.
authors.forename: Pierluigi Benedetti
authors.initials: PB
authors.lastname: Panici
mesh_terms: D000328:Adult; D000465:Algorithms; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006801:Humans; D015907:Hysteroscopy / Q000009:adverse effects / Q000379:methods*; D007889:Leiomyoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D008186:Luteolytic Agents / Q000008:administration & dosage; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology / Q000601:surgery; D020360:Neoadjuvant Therapy; D011183:Postoperative Complications / Q000453:epidemiology; D017329:Triptorelin Pamoate / Q000008:administration & dosage*; D014592:Uterine Hemorrhage / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone