title: Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones.
abstract: Motor proteins are involved in a wide range of cellular and subcellular movements. Recent studies have implicated two motor proteins in particular, myosin II and cytoplasmic dynein, in diverse aspects of cell migration. This review focuses on emerging roles for these proteins in the nervous system, with particular emphasis on migrating neurons and neuronal growth cones. The former cells exhibit unusual features of centrosome and nuclear movement, whereas growth cones offer an opportunity to evaluate motor protein function in a region of cytoplasm free of these organelles.
authors.affiliation: Department of Pathology and Cell Biology, Program in Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA. rv2025@columbia.edu
authors.forename: Richard B
authors.initials: RB
authors.lastname: Vallee
authors.forename: Garrett E
authors.initials: GE
authors.lastname: Seale
authors.forename: Jin-Wu
authors.initials: JW
authors.lastname: Tsai
mesh_terms: D000818:Animals; D002465:Cell Movement; D003593:Cytoplasm / Q000378:metabolism; D004398:Dyneins / Q000378:metabolism*; D006801:Humans; D024462:Myosin Type II / Q000378:metabolism*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism
chemical_list: D024462:Myosin Type II; D004398:Dyneins