title: Enantioselective linchpin catalysis by SOMO catalysis: an approach to the asymmetric alpha-chlorination of aldehydes and terminal epoxide formation.
abstract: Time for SOme MOre: For the first time SOMO (singly occupied molecular orbital) activation has been exploited to allow a new approach to the alpha-chlorination of aldehydes. This transformation can be readily implemented as part of a linchpin catalysis approach to the enantioselective production of terminal epoxides.
authors.affiliation: Merck Center for Catalysis at Princeton University, Washington Road, Princeton NJ 08544-1009, USA.
authors.forename: Muriel
authors.initials: M
authors.lastname: Amatore
authors.forename: Teresa D
authors.initials: TD
authors.lastname: Beeson
authors.forename: Sean P
authors.initials: SP
authors.lastname: Brown
authors.forename: David W C
authors.initials: DW
authors.lastname: MacMillan
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry*; D054879:Halogenation; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D004852:Epoxy Compounds