TfOH-catalyzed intramolecular alkyne-ketone metathesis leading to highly substituted five-membered cyclic enones.
The intramolecular carbocyclization of tethered alkynyl ketones to five-membered cyclic enones is shown to be catalyzed by trifluoromethanesulfonic acid in MeOH, proceeding in good to excellent yields and with high selectivities.
Jin
Tienan
T
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8548, Japan. tjin@mail.tains.tohoku.ac.jp
Yang
Fan
F
Liu
Chunli
C
Yamamoto
Yoshinori
Y