Transcriptional targets in adipocyte biology.
The global burden of metabolic disease demands that we develop new therapeutic strategies. Many of these approaches may center on manipulating the behavior of adipocytes, which contribute directly and indirectly to a host of disease processes including obesity and type 2 diabetes. One way to achieve this goal will be to alter key transcriptional pathways in fat cells, such as those regulating glucose uptake, lipid handling, or adipokine secretion. In this review, we look at what is known about how adipocytes govern their physiology at the gene expression level, and discuss novel ways that we can accelerate our understanding of this area.
Rosen
Evan
E
Beth Israel Deaconess Medical Center, Division of Endocrinology/CLS743, Boston, MA 02215, USA. erosen@bidmc.harvard.edu
Eguchi
Jun
J
Xu
Zhao
Z
D017667:Adipocytes / Q000378:metabolism / Q000473:pathology* / Q000502:physiology; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D009765:Obesity / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D014158:Transcription, Genetic / Q000187:drug effects / Q000502:physiology*