Uterine artery embolization compared with methotrexate for the management of pregnancy implanted within a cesarean scar.
OBJECTIVE
The objective of the study was to compare the efficacy and safety of uterine artery embolization (UAE) vs systemic methotrexate (MTX) for pregnancy within a cesarean scar.


METHODS
Seventy-two women with pregnancy within cesarean scar were randomly allocated to a UAE group (37 cases) or an MTX group (35 cases), which all was followed by suction curettage. The primary outpoints include bleeding loss, serum beta-human chorionic gonadotropin level, and side effects.


RESULTS
The bleeding volumes were 36.93 +/- 6.01 mL in the UAE group and 415.63 +/- 68.37 mL in the MTX group (P < .001). The hospitalization time was 11.73 +/- 0.80 days in the UAE group and 39.63 +/- 4.57 days in the MTX group (P < .001). There was no severe side effect in both groups.


CONCLUSIONS
For pregnancy within a cesarean scar, UAE followed by suction curettage appears to have more advantage and may be a priority option.
Zhuang
YaLing
Y
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310006, People's Republic of China.
Huang
LiLi
L
D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D000028:Abortion, Induced / Q000379:methods; D000328:Adult; D002921:Cicatrix; D003131:Combined Modality Therapy; D010064:Embryo Implantation; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D011446:Prospective Studies; D014463:Ultrasonography; D055357:Uterine Artery Embolization; D014592:Uterine Hemorrhage / Q000517:prevention & control; D014599:Uterus / Q000098:blood supply / Q000473:pathology
D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate