title: Substrate specificity of lipase from Burkholderia cepacia in the synthesis of 3'-arylaliphatic acid esters of floxuridine.
abstract: Among the five vinyl esters bearing phenyl ring in acyl moiety, the lipase from Burkholderia cepacia was most specific toward vinyl 4-phenylbutyrate. Additionally, 3'-regioselectivity of the enzyme was enhanced with the increment of acyl chain length. The lipophilic 3'-arylaliphatic acid esters of floxuridine, its potential prodrugs, were synthesized with high conversions (>98%) and good to excellent regioselectivities (85-99%) via the enzymatic approach.
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Quan-Ming
authors.initials: QM
authors.lastname: Zeng
authors.forename: Min-Hua
authors.initials: MH
authors.lastname: Zong
mesh_terms: D000215:Acylation; D016956:Burkholderia cepacia / Q000201:enzymology*; D005227:Fatty Acids / Q000378:metabolism*; D005467:Floxuridine / Q000031:analogs & derivatives* / Q000378:metabolism; D008049:Lipase / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D005227:Fatty Acids; D005467:Floxuridine; D008049:Lipase