title: Clinical profile of chikungunya fever in patients in a tertiary care centre in Maharashtra, India.
abstract: OBJECTIVE
  In India a chikungunya fever outbreak started in December 2005 when the country experienced more than 13 lakhs of chikungunya infected cases. We undertook this study to study detailed clinical profile of chikungunya fever in both indoor and outdoor patients in a tertiary care hospital in Nagpur, Maharashtra in 2006.
  
  
  METHODS
  Suspected cases of chikungunya fever (n=405) during the period of July to September 2006, having clinical triad of fever, arthralgia and/or rashes were included in the study. Clinical profile was studied in all the cases. Of the 405 samples collected, 166 were tested for serum CHIK IgM antibodies.
  
  
  RESULTS
  Of the 166 samples tested for CHIKV IgM antibodies, 87 (52.4%) were positive (confirmed cases). Male: female ratio was 2.3:1. Fever and arthralgia were present in all cases. Rash was present in 27 (31%) confirmed and 38 (12%) suspected cases. Lymphadenopathy was present in 12 (13.8 %) confirmed and 4 of suspected cases. Chronic polyarthritis was seen in 22 (25.3%) confirmed and 75 (23.6%) suspected cases. Neurological manifestations were observed in 08 (9%) confirmed and 10 (3.14%) suspected cases. Mortality was 7 (2.2%) in 318 suspected cases and 3 (3.4%) in 87 confirmed cases.
  
  
  CONCLUSIONS
  Our findings showed that about half of the serum samples for CHIKV IgM antibody tested positive from cases suspected to have chikungunya fever. Fever, joint pain and headache were major symptoms. Certain rare manifestations like lymphodenopathy, oral ulcers and encephalitis were also seen. Mortality in confirmed cases was about 3.4 per cent.
authors.affiliation: Department of Medicine, Indira Gandhi Government Medical College, Nagpur, India.
authors.forename: S D
authors.initials: SD
authors.lastname: Suryawanshi
authors.forename: A H
authors.initials: AH
authors.lastname: Dube
authors.forename: R K
authors.initials: RK
authors.lastname: Khadse
authors.forename: S V
authors.initials: SV
authors.lastname: Jalgaonkar
authors.forename: P S
authors.initials: PS
authors.lastname: Sathe
authors.forename: S D
authors.initials: SD
authors.lastname: Zawar
authors.forename: M P
authors.initials: MP
authors.lastname: Holay
mesh_terms: D000293:Adolescent; D000328:Adult; D018354:Alphavirus Infections / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D002646:Chikungunya virus / Q000235:genetics*; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007194:India / Q000453:epidemiology; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D007075:Immunoglobulin M