title: Clinicopathological features in endometrial carcinoma associated with Lynch syndrome in China.
abstract: OBJECTIVE
  To study the clinicopathological characteristics of Lynch syndrome-associated endometrial carcinoma in China.
  
  
  METHODS
  Twenty-seven patients who fulfilled Amsterdam criteria II were classified as having Lynch syndrome-associated endometrial carcinoma (group A), and 331 patients without a family history of cancer were classified as having sporadic endometrial carcinoma (group B).
  
  
  RESULTS
  There were 81 malignancies in 27 families with Lynch syndrome-associated endometrial carcinoma, including colorectal cancer (24.7%), endometrial carcinoma (21.0%), and liver (12.3%), stomach (9.9%), lung (6.2%), and breast (6.2%) cancers. Mean age at the time of diagnosis was 49.7 years in group A and 56.3 years in group B (P = 0.004). Second primary cancers occurred in 33.3% of patients in group A and 5.1% in group B (P = 0.000). The most common second primary cancers were colorectal cancer (44%) and ovarian cancer (22%). The percentage of obese patients was higher in group A (P= 0.013). There was no difference between the 2 groups in incidence of diabetes mellitus or hypertension or in histological type and International Federation of Gynecology and Obstetrics stage. The 5-year survival rates for groups A and B were 96.2% and 79.6%, respectively. Prognosis for group A was better than for group B (P = 0.045).
  
  
  CONCLUSIONS
  Some clinicopathological features of Lynch syndrome-associated endometrial carcinoma, such as early onset and multiple primary carcinomas are similar in the Chinese and American/European populations. However, the Chinese population had a unique family cancer distribution that included lung and breast cancers. Well-differentiated grade and good prognosis imply better biobehavior of Lynch syndrome-associated endometrial carcinoma in the Chinese population.
authors.affiliation: Department of Obstetrics and Gynecology, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Yingmei
authors.initials: Y
authors.lastname: Wang
authors.forename: Fengxia
authors.initials: F
authors.lastname: Xue
authors.forename: Russell R
authors.initials: RR
authors.lastname: Broaddus
authors.forename: Xia
authors.initials: X
authors.lastname: Tao
authors.forename: Su-su
authors.initials: SS
authors.lastname: Xie
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies