title: The proteasome's crown for destruction.
abstract: Three recent Molecular Cell papers from Zhang et al. (2009a, 2009b) and Djuranovic et al. (2009) provide new insights into how proteasomal ATPases recognize, unfold, and translocate their substrates, thus enhancing our understanding of regulated proteolysis.
authors.affiliation: Laboratory of Frontier Science, Core Technology and Research Center, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Sakata
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saeki
authors.forename: Keiji
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism / Q000502:physiology; D008958:Models, Molecular; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000502:physiology*; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism
chemical_list: D011506:Proteins; D046988:Proteasome Endopeptidase Complex; D000251:Adenosine Triphosphatases