[Diagnostic value of lesion-directed prostate biopsy under TRUS in early detection of prostate cancer].
OBJECTIVE
To evaluate lesion-directed biopsy in improving the detection rate of early prostate cancer (PCa) and in differentiating PCa from other prostate pathological changes.


METHODS
We performed TRUS-guided prostate biopsy for 95 patients suspected of PCa, each subjected to extended random biopsy plus lesion-directed biopsy, and analyzed the sonographic characteristics and pathological findings.


RESULTS
PCa was detected in 35 of the patients (36.8%), including 16 hypoechoic (45.7%), 4 hyperechoic (11.4%), 10 isoechoic (28.6%) and 5 mixed hetero-echoic lesions (14.3%). Of the 35 PCa cases, 17 (46.2%) were within T2b, 70.6% (12/17) of which were detected by lesion-directed biopsy and 29.4% (5/17) by sextant biopsy, the former obviously higher than the latter (P < 0.05).


CONCLUSIONS
Lesion-directed prostate biopsy under TRUS can significantly improve the early diagnosis of prostate cancer, increase convenience and reduce patients' pain, but is not sufficient to replace traditional sextant biopsy.
Zhu
Jiang
J
Department of Ultrasound, The Second Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. zhujiang1963@126.com
Liu
Xue-Ming
XM
Du
Chuan-Jun
CJ
Zhang
Zhe-Wei
ZW
Qiu
Yi-Qing
YQ
Gong
Yu
Y
Liu
Jing-Rui
JR
Hong
Yu-Rong
YR
Luo
Zhi-Yan
ZY
Zhang
Yong
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D018084:Ultrasonography, Interventional