Akt and PTEN: beta-cell mass and pancreas plasticity.
The capacity of pancreatic beta-cells to adapt to insulin resistance is crucial for glucose homeostasis and is a factor in the development of type 2 diabetes. The insulin receptor substrate (insulin receptor 2/phosphoinositide 3-kinase [PI3K]) pathway plays a crucial part in regulating beta-cell mass and function. The serine-threonine kinase Akt, also known as protein kinase B, is one of the major downstream targets of the PI3K pathway and is negatively regulated by phosphatase and tensin homologue deleted on chromosome 10. This Akt signaling pathway has recently been implicated in cell-cycle progression and survival of pancreatic beta-cells. Understanding the mechanisms that link Akt to modulation of beta-cell mass, function and plasticity will positively affect treatment of human diabetes.
Elghazi
Lynda
L
Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine Saint-Louis, MO 63110, USA.
Bernal-Mizrachi
Ernesto
E
D000818:Animals; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D051059:PTEN Phosphohydrolase / Q000378:metabolism / Q000502:physiology*; D010179:Pancreas / Q000378:metabolism* / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D051057:Proto-Oncogene Proteins c-akt; D051059:PTEN Phosphohydrolase