[Detection of oncoprotein E7 HPV16 in the cancer and normal urinary bladder urothelium].
Oncoprotein E7 HPV16 was detected by immunohistochemical staining with specific polyclonal antiserum [Fiedler et al., 2004] in 7 out of the 24 (29.2%) studied bladder cancer specimens. The result is in good agreement with the hypothesis that HPVs take part in the carcinogenesis of the urothelium. However, some of the observations made seem rather hard to be interpreted at present. The latter include the detection of E7 HPV16 in a small number of cancer cells in a few bladder cancer specimens being examined; the presence of this protein in the cytoplasm, rather in the cancer cell nuclei, and its detection in some morphologically normal bladder urothelial specimens from non-cancer patients. Thus, the hypothesis that HPVs are implicated in the carcinogenesis of the bladder urothelium deserves further verification.
Volgareva
G M
GM
Zavalishina
L E
LE
Golovina
D A
DA
Andreeva
Iu Iu
IuIu
Ermilova
V D
VD
Cheban
N L
NL
Kuevda
D A
DA
Trofimova
O B
OB
Shipulina
O Iu
OIu
Pavlova
L S
LS
Petrov
A N
AN
Matveev
V B
VB
Shtil'
A A
AA
Frank
G A
GA
D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology / Q000821:virology; D003593:Cytoplasm / Q000378:metabolism / Q000473:pathology / Q000821:virology; D005260:Female; D052162:Human papillomavirus 16; D006801:Humans; D008297:Male; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D050725:Papillomavirus E7 Proteins; D030361:Papillomavirus Infections / Q000378:metabolism* / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000821:virology; D019459:Urothelium / Q000378:metabolism / Q000473:pathology / Q000821:virology
D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; C059731:oncogene protein E7, Human papillomavirus type 16