Successful absorption of antiretroviral drugs after gastrojejunal bypass surgery following failure of therapy through a jejunal tube.
Lopinavir, an antiretroviral drug against human immunodeficiency virus (HIV), was administered through various routes to an HIV-infected patient with duodenal malignant lymphoma. Antiretroviral drugs were first administered through a jejunal tube, and then through bypass route between the stomach and jejunum that was 20 cm distal from the ligament of Treitz after surgery. Oral administration through the bypass achieved sufficient serum concentrations of lopinavir, whereas administration through the jejunal tube did not.
Kamimura
Mahoko
M
AIDS Clinical Center, International Medical Center of Japan, Tokyo. mhk-kamimura@umin.ac.jp
Watanabe
Koji
K
Kobayakawa
Masao
M
Mihara
Fuminori
F
Edamoto
Yoshihiro
Y
Teruya
Katsuji
K
Kikuchi
Yoshimi
Y
Oka
Shinichi
S
D000284:Administration, Oral; D000328:Adult; D044966:Anti-Retroviral Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D004379:Duodenal Neoplasms / Q000601:surgery; D015390:Gastric Bypass; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism / Q000601:surgery; D061466:Lopinavir; D008223:Lymphoma / Q000601:surgery; D008297:Male; D011744:Pyrimidinones / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*
D044966:Anti-Retroviral Agents; D011744:Pyrimidinones; D061466:Lopinavir