title: Study of drug transport between the blood and lymph in the predominant direction.
abstract: Our method for evaluating the time course and intensity of antibiotics and other drugs transport in the predominant direction between the blood and lymph in humans promotes a more objective evaluation of drug circulation mechanisms, which is essential for determining the time of their repeated administration and route of administration. Calculation of the lymph/blood difference coefficient, based on parallel repeated measurements of the drug concentration in the lymph and blood, and of the lymph/blood coefficient provides complete data on the direction and time course of drug transport between the lymph and blood in the predominant direction.
authors.affiliation: Moscow Medical Stomatological Institute, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Petrovich
authors.forename: I V
authors.initials: IV
authors.lastname: Yarema
authors.forename: S M
authors.initials: SM
authors.lastname: Kichenko
authors.forename: B M
authors.initials: BM
authors.lastname: Urtaev
mesh_terms: D000667:Ampicillin / Q000097:blood / Q000493:pharmacokinetics; D001692:Biological Transport / Q000502:physiology*; D006801:Humans; D007612:Kanamycin / Q000097:blood / Q000493:pharmacokinetics; D008196:Lymph / Q000378:metabolism*; D009827:Oleandomycin / Q000097:blood / Q000493:pharmacokinetics; D010538:Peritonitis / Q000188:drug therapy; D004364:Pharmaceutical Preparations / Q000097:blood*; D013752:Tetracycline / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D004364:Pharmaceutical Preparations; D007612:Kanamycin; D000667:Ampicillin; C011354:sigmamycin; D013752:Tetracycline; D009827:Oleandomycin