Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosis.
Vitamin D has been associated with a decreased risk of multiple sclerosis (MS). In this study, serum 1, 25-dihydroxyvitamin D (1, 25-(OH)2 vitD) and 25-hydroxyvitamin D (25-OH vitD), regulatory T cell percentages and naïve and memory T helper cell subsets were measured in 26 patients with multiple sclerosis, 21 who were not on treatment with disease modifying therapy. These studies showed an inverse correlation between 25-OH vitD levels and Treg cell percentages and a direct correlation between Treg cell percentages and 1, 25-(OH)2 vitD:25-OH vitD ratios. In addition, 25-OH vitD levels correlated directly and 1, 25-(OH)2 vitD:25-OH vitD ratios correlated inversely with CXCR3+ naïve T helper cell percentages and CXCR3+naïve:CXCR3+ memory T helper cell ratios. All together, these data demonstrate that vitamin D measurements can reflect measures of immune status among patients with MS.
Royal
Walter
W
University of Maryland School of Medicine, Maryland Center for Multiple Sclerosis Treatment and Research, Baltimore, MD 21201, USA. wroyal@som.umaryland.edu
Mia
Younus
Y
Li
Huifen
H
Naunton
Kerry
K
D015650:24,25-Dihydroxyvitamin D 3 / Q000032:analysis / Q000097:blood; D000328:Adult; D015551:Autoimmunity / Q000276:immunology; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology* / Q000503:physiopathology; D054367:Receptors, CXCR3 / Q000032:analysis / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000276:immunology; D014807:Vitamin D / Q000031:analogs & derivatives / Q000032:analysis / Q000097:blood*
D015415:Biomarkers; C515187:CXCR3 protein, human; D054367:Receptors, CXCR3; D014807:Vitamin D; D015650:24,25-Dihydroxyvitamin D 3; C104450:25-hydroxyvitamin D