[Lipid peroxidation and cytochrome P-450-dependent metabolism of xenobiotics in patients with coronary heart disease and multiple organ failure].
The aim of the investigation was to study oxidative stress and hepatic monooxygenase function (HMF) in coronary heart disease (CHD) patients with multiple organ dysfunction (MOD) after myocardial revascularization. Twenty-seven CHD patients with signs of MOD and 38 patients with an uncomplicated postoperative period were examined. The intensity of MOD was rated by the SOFA scale; oxidative stress was estimated from the values of malondialdehyde, conjugate trienes, ceruplasmin, and catalase, and HMF was evaluated from antipyrine pharmacokinetic data. On postoperative day 1, the study group showed significant signs of MOD, as well as activated lipid peroxidation (LPO) and a 1.5-fold reduction in HMF. The control group displayed an insignificant HMF suppression under less marked oxidative stress. On days 3-4 after surgery, the total MOD index was noticeably lowered. Both groups exhibited a high LPO rate and enhanced HMF. On days 10-12 postoperatively, the severity of MOD corresponded to the previous period. There was a decrease in LPO activity in both groups. HMF was found to substantially reduce in the study group and to be in line with the baseline values in the control one. Correlation analysis revealed direct and inverse relationships of the indices of MOD with LPO rates and HMF. Therefore, MOD in patients with CHD is attended by increased oxidative stress and leads to a more significant HMF reduction as compared with those with an uncomplicated postoperative period. At the same time, LPO activation is one of the cardinal causes of HMF suppression. Reduced HMF may enhance the sensitivity of CHD patients to drug therapy.
Nepomniashchikh
V A
VA
Lomivorotov
V V
VV
Deriagin
M N
MN
Lomivorotov
V N
VN
Kniaz'kova
L G
LG
Efimov
A A
AA
D003580:Cytochromes / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008111:Liver Function Tests; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism; D017202:Myocardial Ischemia / Q000201:enzymology / Q000378:metabolism / Q000601:surgery*; D009204:Myocardial Revascularization / Q000379:methods; D018384:Oxidative Stress; D011183:Postoperative Complications / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism; D012720:Severity of Illness Index; D015262:Xenobiotics / Q000378:metabolism* / Q000493:pharmacokinetics
D003580:Cytochromes; D015262:Xenobiotics; C013464:cytochrome P420