Imaging of optic nerve head drusen: improvements with spectral domain optical coherence tomography.
OBJECTIVE
To demonstrate a new algorithm that can determine the shape, location, and volume of optic nerve head drusen (ONHD), which were imaged with spectral domain optical coherence tomography (SDOCT).


METHODS
One exenteration patient and 4 glaucoma patients with bilateral ONHD were recruited from the Massachusetts Eye and Ear Infirmary and from a private practice office. Images were obtained using an experimental SDOCT system developed at the Wellman Center for Photomedicine, Massachusetts General Hospital. With axial resolutions of about 6 mum, SDOCT can obtain 2-dimensional images in 1/29 of a second, compared with commercially available time domain OCT instruments with 10 mum resolution images in 1.28 seconds. The volumes of ONHD were calculated with a new algorithm and were then correlated with visual field mean deviation.


RESULTS
SDOCT can display 2-dimensional images comparable with histology and 3-dimensional videos of ONHD. ONHD are signal-poor regions with high-signaled borders. Larger ONHD volumes are directly correlated with larger mean deviation absolute values on Humphrey visual field testing.


CONCLUSIONS
SDOCT is a potentially better technique for ONHD imaging and may improve the diagnosis and management of patients with both OHND and glaucoma.
Yi
Kayoung
K
Harvard Medical School, Department of Ophthalmology, Glaucoma Service, Massachusetts General Hospital, Boston, MA, USA.
Mujat
Mircea
M
Sun
Wei
W
Burnes
Daina
D
Latina
Mark A
MA
Lin
Derrick T
DT
Deschler
Daniel G
DG
Rubin
Peter A D
PA
Park
Boris Hyle
BH
de Boer
Johannes F
JF
Chen
Teresa C
TC
D000368:Aged; D000465:Algorithms; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D015594:Optic Disk Drusen / Q000150:complications / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000592:standards; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology; D058609:Visual Field Tests / Q000379:methods; D014794:Visual Fields