Trisulfonated porphyrazines: new photosensitizers for the treatment of retinal and subretinal edema.
A new series of water-soluble, mononaphthotrisulfobenzoporphyrazines, bearing an alkynyl side chain of varying lengths on the naphtho ring, were prepared and tested for their efficacy to inhibit plasma extravasation when used as photosensitizers during photodynamic therapy (PDT) of the retina in the rat. The hexynyl substituted photosensitizer was the most potent, and was able to produce complete inhibition, at low doses of photosensitizer and light.
van Lier
Johan E
JE
Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada. johan.e.vanlier@usherbrooke.ca
Tian
Hongjian
H
Ali
Hasrat
H
Cauchon
Nicole
N
Hasséssian
Haroutioun M
HM
D000818:Animals; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy; D010211:Papilledema / Q000097:blood / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use*; D011166:Porphyrins / Q000737:chemistry* / Q000627:therapeutic use*; D051381:Rats; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
D017319:Photosensitizing Agents; D011166:Porphyrins; D014867:Water