Phospholipase D in endocytosis and endosomal recycling pathways.
The discovery that Arf GTPases, mediators of membrane traffic, activate phospholipase D (PLD) raised the possibility that Arfs could facilitate membrane traffic by altering membrane lipid composition. PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. This review examines studies that have reported a role for PLD in endocytosis and membrane recycling from endocytic pathways.
Donaldson
Julie G
JG
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 2503, Bethesda, MD 20892, USA. jdonalds@helix.nih.gov
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004705:Endocytosis; D011992:Endosomes / Q000201:enzymology*; D006801:Humans; D010739:Phospholipase D / Q000737:chemistry / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
D011956:Receptors, Cell Surface; D010739:Phospholipase D