title: [The expression of PTEN and P16 protein in nasal inverted papilloma].
abstract: OBJECTIVE
  To explore the expression of PTEN and P16 protein, and its relationship with the occurrence, development and prognosis of nasal inverted papilloma (NIP).
  
  
  METHODS
  The expressions of PTEN and P16 were detected in 27 cases with NIP and 10 cases with normal mucosa of sphenoid by immunohistochemistry and image analytical system, and were analyzed in NIP cases with different prognosis.
  
  
  RESULTS
  The positive expression PTEN and P16 protein were both significantly decreased compared with normal sinus mucosa (P<0.05). There was a significant difference of the PTEN expression between NIP with no-recurrence and that recurred (P<0.05). The expression of P16 protein decrease in different NIP groups but there was no statistic significance between them (P>0.05).
  
  
  CONCLUSIONS
  Decreasing or depletion of PTEN might be a sign of NIP development and unfavorable prognosis, and P16 protein is also closely related with the occurrence of NIP.
authors.affiliation: Department of Otolaryngology, the Second Hospital, Shandong University, Jinan, 250033, China. zhaojd.jack@yahoo.com.cn
authors.forename: Jiandong
authors.initials: J
authors.lastname: Zhao
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Wang
authors.forename: Weijia
authors.initials: W
authors.lastname: Kong
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D018308:Papilloma, Inverted / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human