title: No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.
abstract: The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased alpha-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific.
authors.affiliation: Prince of Wales Medical Research Institute and School of Medical Sciences, Faculty of Medicine University of New South Wales, Sydney, Australia. g.halliday@powmri.edu.au
authors.forename: Glenda
authors.initials: G
authors.lastname: Halliday
authors.forename: Maria Trinidad
authors.initials: MT
authors.lastname: Herrero
authors.forename: Karen
authors.initials: K
authors.lastname: Murphy
authors.forename: Heather
authors.initials: H
authors.lastname: McCann
authors.forename: Francisco
authors.initials: F
authors.lastname: Ros-Bernal
authors.forename: Carlos
authors.initials: C
authors.lastname: Barcia
authors.forename: Hideo
authors.initials: H
authors.lastname: Mori
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Blesa
authors.forename: José A
authors.initials: JA
authors.lastname: Obeso
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D016631:Lewy Bodies / Q000473:pathology*; D008137:Longitudinal Studies; D020267:MPTP Poisoning / Q000378:metabolism / Q000473:pathology*; D008252:Macaca fascicularis; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D051844:alpha-Synuclein; D014446:Tyrosine 3-Monooxygenase