title: Ammonificins A and B, hydroxyethylamine chroman derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans.
abstract: Two hydroxyethylamine chroman derivatives, ammonificins A (1) and B (2), were isolated from the marine hydrothermal vent bacterium Thermovibrio ammonificans. The molecular structures of these compounds were determined using a combination of NMR, mass spectrometry, and CD analyses. Biological activities were determined using an antimicrobial assay and the patented ApopScreen cell-based screen for apoptosis induction and potential anticancer activity. To our knowledge, this is the first report of secondary metabolites from the marine hydrothermal vent bacterium T. ammonificans.
authors.affiliation: Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Jersey 08901-8521, USA.
authors.forename: Eric H
authors.initials: EH
authors.lastname: Andrianasolo
authors.forename: Liti
authors.initials: L
authors.lastname: Haramaty
authors.forename: Richard
authors.initials: R
authors.lastname: Rosario-Passapera
authors.forename: Kelly
authors.initials: K
authors.lastname: Bidle
authors.forename: Eileen
authors.initials: E
authors.lastname: White
authors.forename: Costantino
authors.initials: C
authors.lastname: Vetriani
authors.forename: Paul
authors.initials: P
authors.lastname: Falkowski
authors.forename: Richard
authors.initials: R
authors.lastname: Lutz
mesh_terms: D017209:Apoptosis; D001419:Bacteria / Q000737:chemistry*; D002839:Chromans / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D002839:Chromans; C542222:ammonificin A; C542221:ammonificin B