[Effects of propofol induction on haemodynamics].
BACKGROUND
Propofol is probably the most popular intravenous anaesthetic in daily practice. Its use is known to be associated with dose-dependent cardiovascular compromise. We have assessed the effect of a single dose of propofol on cardiovascular function.


METHODS
Eighty-six ASA I and II patients of both sexes, scheduled for elective thoracic cancer surgery, were enrolled to the study. Midazolam 7.5 mg was given as premedication. All patients received epidural or paravertebral catheters one day before the surgery, and a Swan-Ganz catheter before induction. MAP, CO, SVI, PAP, PCWP, SVRI, PVRI, LVSWI, RWSWI and CPP were measured before induction (I) and after administration of 1 mg kg(-1) propofol with 1-3 microg kg(-1) fentanyl, during spontaneous respiration (II).


RESULTS
Propofol increased: heart rate (8%), PAP (12%), PVRI (27%), PCWP (27%) and decreased MAP (4.5%), CI (12%), SVI (18%), LVSWI (23%), RVSWI (17%). CPP decreased by 7%. SVRI remained unchanged.


CONCLUSIONS
The results indicated that 1 mg kg(-1) propofol moderately compromised cardiac contractility and increased afterload on the right ventricle, without significant effect on coronary perfusion pressure. The cardiovascular compromise was clinically insignificant, but caution is required when propofol is administered in larger doses.
Machała
Waldemar
W
II Zakład Anestezjologii i Inensywnej Terapii UM w Łodzi. w.machala@skwam.lodz.pl
Szebla
Renata
R
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D015742:Propofol / Q000009:adverse effects*; D013318:Stroke Volume / Q000187:drug effects; D019616:Thoracic Surgical Procedures; D016278:Ventricular Function, Right / Q000187:drug effects
D018686:Anesthetics, Intravenous; D015742:Propofol