Pregnancy outcome in women with factor V Leiden and recurrent miscarriage.
We compared the outcome of 25 untreated pregnancies among women with recurrent miscarriage (RM) at <12 weeks' gestation who were heterozygous for factor V Leiden with women with unexplained RM. The livebirth rate was lower among pregnancies in carriers of factor V Leiden (12/25; 48%) compared with pregnancies in women with unexplained RM (175/307; 57%), but the difference did not reach statistical significance. The best possible treatment regimen to improve livebirth rate in this group of women needs to be assessed in the form of a randomised controlled trial.
Jivraj
S
S
Department of Obstetrics & Gynaecology, Jessop Wing, Sheffield, UK. sjivraj007@aol.com
Makris
M
M
Saravelos
S
S
Li
T C
TC
D000026:Abortion, Habitual / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D005165:Factor V / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006720:Homozygote; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000235:genetics*; D011256:Pregnancy Outcome; D012307:Risk Factors; D055815:Young Adult
C095381:factor V Leiden; D005165:Factor V