Alloantibodies and outcomes of deceased donor kidney allografts.
Analysis of the anti-HLA antibody status of 100 recipients of kidneys from deceased donors demonstrated that presensitization and the development of alloantibodies after transplantation are associated with the development of antibody mediated as well as cellular rejection. This finding indicates that the humoral arm of the immune response is also involved in cell-mediated rejection and/or that there may be a continuum between these two forms of rejection. Most episodes of rejection were successfully reversed in our population, as shown by the overall 3-year actuarial survival of 98% in nonsensitized and 91% in sensitized recipients, emphasizing the importance of comprehensive antibody studies.
Cinti
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Chirurgia Generale E Trapianti d'Organo, La Sapienza Università di Roma, Umberto I Policlinico di Roma, Rome, Italy.
Pretagostini
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R
Lai
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Tamburro
M L
ML
Rossi
M
M
Poli
L
L
Berloco
P
P
D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002102:Cadaver; D003165:Complement System Proteins / Q000276:immunology / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D007114:Immunization; D007163:Immunosorbent Techniques; D007165:Immunosuppression Therapy; D015994:Incidence; D007518:Isoantibodies / Q000097:blood / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology*; D016030:Kidney Transplantation; D008991:Monitoring, Physiologic; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014019:Tissue Donors; D014184:Transplantation, Homologous
D007518:Isoantibodies; D007519:Isoantigens; D003165:Complement System Proteins