Synergy effects of the antibiotics gentamicin and the essential oil of Croton zehntneri.
The leaves of Croton zehntneri Pax et Hoffm (Euphorbiaceae) were subjected to hydrodistillation, and the essential oil extracted was examined with respect to antibacterial and antibiotic modifying activity by gaseous contact. The gaseous component of the oil inhibited the bacterial growth of Staphylococcus aureus and Pseudomonas aeruginosa with a MID of 0.5 and<1mg/l air, respectively. The activity of the antibiotic gentamicin was increased by 42,8% against P. aeruginosa after contact with the gaseous component, showing that this oil influences the activity of the antibiotic and may be used as an adjuvant in the antibiotic therapy of respiratory tract bacterial pathogens.
Rodrigues
Fabíola F G
FF
Faculdade Leão Sampaio, Juazeiro do Norte, CE, Brazil.
Costa
José G M
JG
Coutinho
Henrique D M
HD
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D029802:Croton / Q000737:chemistry*; D003436:Croton Oil / Q000302:isolation & purification / Q000494:pharmacology*; D004357:Drug Synergism; D005839:Gentamicins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D003436:Croton Oil