title: Low in vivo brain glucose consumption and high oxidative stress in accelerated aging.
abstract: The validity of the free radical theory of aging has been recently questioned. Our aim was to test whether there is oxidative stress in tissues critically involved in accelerated aging (senescence-accelerated mice, SAM) and whether this correlates with lower glucose consumption in vivo and behavioural tests. Positron emission tomography shows that brains of old SAM-prone animals consume less glucose than young ones. Behavioural characteristics, mitochondrial peroxide production, and damage in both the central nervous system and bone marrow stem cells also indicate that SAM-prone animals age faster than SAM-resistant ones. Our results support the role of the free radical theory of aging in critical tissues involved in aging and that this correlates with glucose consumption.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain. Consuelo.Borras@uv.es
authors.forename: Consuelo
authors.initials: C
authors.lastname: Borrás
authors.forename: Sergey
authors.initials: S
authors.lastname: Stvolinsky
authors.forename: Raúl
authors.initials: R
authors.lastname: López-Grueso
authors.forename: Tatiana
authors.initials: T
authors.lastname: Fedorova
authors.forename: Juan
authors.initials: J
authors.lastname: Gambini
authors.forename: Alexander
authors.initials: A
authors.lastname: Boldyrev
authors.forename: Jose
authors.initials: J
authors.lastname: Viña
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D005609:Free Radicals; D005947:Glucose