title: [Efficacy and safety of tulosine in patients with prostatic adenoma].
abstract: The study of tulosine (tamsulosine) efficacy and safety was made in 92 patients with lower urinary tract symptoms (LUTS) due to prostatic adenoma (PA). Tulosine treatment relieved both obstructive and irritative symptoms, IPSS parameters improved by 8.0 +/- 0.3 points, QoL--by 1.4 +/- 0.1 points, Qmax--by 2.6 +/- 0.3 ml/s. Ultrasound investigation found no significant changes in the adenoma size. Residual urine volume reduced from 42.4 to 19.7 ml (by 53.7%). Blood pressure lowered insignificantly. Side effects were mild. Thus, tulosine is a safe and effective drug for treatment of prostatic adenoma.
authors.forename: L M
authors.initials: LM
authors.lastname: Gorilkovskiĭ
authors.forename: M B
authors.initials: MB
authors.lastname: Zingerenko
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000503:physiopathology; D011788:Quality of Life; D013449:Sulfonamides / Q000008:administration & dosage* / Q000009:adverse effects*; D000077409:Tamsulosin
chemical_list: D000970:Antineoplastic Agents; D013449:Sulfonamides; D000077409:Tamsulosin