title: Oseltamivir- and amantadine-resistant influenza viruses A (H1N1).
abstract: Surveillance of amantadine and oseltamivir resistance among influenza viruses was begun in Hong Kong in 2006. In 2008, while both A/Brisbane/59/2007-like and A/Hong Kong/2652/2006-like viruses (H1N1) were cocirculating, we detected amantadine and oseltamivir resistance among A/Hong Kong/2652/2006-like viruses (H1N1), caused by genetic reassortment or spontaneous mutation.
authors.affiliation: Centre for Health Protection, Hong Kong Special Administrative Region, People's Republic of China.
authors.forename: Peter K C
authors.initials: PK
authors.lastname: Cheng
authors.forename: Tommy W C
authors.initials: TW
authors.lastname: Leung
authors.forename: Eric C M
authors.initials: EC
authors.lastname: Ho
authors.forename: Peter C K
authors.initials: PC
authors.lastname: Leung
authors.forename: Anita Y Y
authors.initials: AY
authors.lastname: Ng
authors.forename: Mary Y Y
authors.initials: MY
authors.lastname: Lai
authors.forename: Wilina W L
authors.initials: WW
authors.lastname: Lim
mesh_terms: D000547:Amantadine / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D024882:Drug Resistance, Viral / Q000235:genetics*; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006723:Hong Kong; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000821:virology*; D053139:Oseltamivir / Q000494:pharmacology*; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000379:methods; D011159:Population Surveillance; D017422:Sequence Analysis, DNA
chemical_list: D000998:Antiviral Agents; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D053139:Oseltamivir; D000547:Amantadine