title: Use of the aromatase inhibitor letrozole to treat male infertility.
abstract: OBJECTIVE
  Report the case of induction of spermatogenesis with the aromatase inhibitor letrozole.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University Infertility center.
  
  
  METHODS
  A 31-year-old man with primary infertility, normal volume azoospermia, normal follicle stimulating hormone (FSH) levels and pattern of nonobstructive azoospermia (NOA) on a testicular biopsy.
  
  
  METHODS
  The patient was given the aromatase inhibitor letrozole for 4 months and had repeated FSH, testosterone, LH levels, semen analyses, and finally a testicular biopsy.
  
  
  METHODS
  Results of a testis biopsy.
  
  
  RESULTS
  Testis biopsy showed normal spermatogenesis following 4 months of letrozole therapy.
  
  
  CONCLUSIONS
  This is the first case report on the use of letrozole to treat male infertility and the first case report on the induction of spermatogenesis in a man with NOA using any aromatase inhibitor.
authors.affiliation: Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. kochman@hadassah.org.il
authors.forename: Geneviève
authors.initials: G
authors.lastname: Patry
authors.forename: Keith
authors.initials: K
authors.lastname: Jarvi
authors.forename: Ethan D
authors.initials: ED
authors.lastname: Grober
authors.forename: Kirk C
authors.initials: KC
authors.lastname: Lo
mesh_terms: D000328:Adult; D047072:Aromatase Inhibitors / Q000008:administration & dosage*; D053713:Azoospermia / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D000077289:Letrozole; D008297:Male; D009570:Nitriles / Q000008:administration & dosage*; D013091:Spermatogenesis / Q000187:drug effects*; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*
chemical_list: D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole