Granulomatous inflammation in the lungs of mice with systemic candidiasis receiving a composition of amphotericin B and dialdehyde dextran.
A composition of amphotericin B and dialdehyde dextran was used for the therapy of male C57Bl/6 mice with systemic candidiasis. The composition was more effective than free amphotericin B. A decrease in the number and size of candidal granulomas in the lungs was more significant after therapy with the study composition (compared to free amphotericin B).
Shkurupiy
V A
VA
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Chernova
T G
TG
Nadeev
A P
AP
D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy* / Q000276:immunology; D003911:Dextrans / Q000627:therapeutic use*; D006099:Granuloma / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D000935:Antifungal Agents; D003911:Dextrans; C026948:dextran dialdehyde; D000666:Amphotericin B