Effects of histochrom and emoxypin on biophysical properties of electroexitable cells.
Comparative investigation of effects of antioxidant agents histochrom and emoxypin on biophysical characteristics of isolated neurons from shell Lymnaea stagnalis under normal conditions and during oxidative stress was performed. Differently directed effects of these compounds on resting potential and transmembrane ion currents of neural cells under normal conditions were detected. Histochrom provides hyperpolarizing and emoxypin--depolarizing effect on neuronal membrane potential. Under conditions of oxidative stress both products possess antioxidant action. Obtained data allows coming closer to understanding of cellular-molecular mechanisms of protective action of compounds.
Mischenko
N P
NP
Pacific Institute of Bioorganic Chemistry, Far Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
Fedoreev
S A
SA
Zapara
T A
TA
Ratushnyak
A S
AS
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004594:Electrophysiology; D008195:Lymnaea / Q000166:cytology; D008564:Membrane Potentials / Q000187:drug effects*; D009285:Naphthoquinones / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D010847:Picolines / Q000494:pharmacology*
D000975:Antioxidants; D009285:Naphthoquinones; D010847:Picolines; C103614:histochrome; C009820:6-methyl-2-ethyl-3-hydroxypyridine