Transdermal delivery of salbutamol sulphate: formulation and evaluation.
Salbutamol patches were prepared and evaluated. The effect of different Eudragits and various plasticizers on the properties of the patches were studied. Patches were prepared by casting method employing different plasticizers. These patches were evaluated for weight, thickness uniformity, swelling index, tensile strength, elongation percent and moisture absorption capacity. Release was studied. Tensile strength of the patches using Eudragit RS 100 as well as RS100 + L100 and triacetin was the lowest. Formulae containing 10% oleic acid and 5% dimethyl formamide, respectively, showed the highest permeability. These two formulae were studied clinically, the first formula only showed a significant improvement.
El-Gendy
Nashwa A
NA
Pharmaceutics Department, Faculty of Pharmacy, Beni-suef University, Beni-suef, Egypt. nash_gend@yahoo.com
Sabry
Nirmeen A
NA
El-Attar
Mai
M
Omar
Emad
E
Mahmoud
Manal
M
D000279:Administration, Cutaneous; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D010968:Plasticizers / Q000008:administration & dosage / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000008:administration & dosage / Q000737:chemistry; D012867:Skin / Q000378:metabolism; D012995:Solubility; D013718:Tensile Strength
D001993:Bronchodilator Agents; D010968:Plasticizers; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D000420:Albuterol