title: Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression.
abstract: Dissolved organic matter (DOM) in seawater can be defined as the fraction of organic matter that passes through a filter of sub micron pore size. In this study, we have examined the effect of DOM of deep seawater (DSW) from Pacific Ocean on platelet aggregation and atherosclerosis progression. DSW was passed through a series of filters and then through an Octadecyl C18 filter; the retained substance in ethanol was designated as C18 extractable DOM (C18-DOM). Our studies showed that C18-DOM treatment inhibited platelet aggregation, P-selectin expression and activity of COX-1 significantly. C18-DOM increased the expression of anti-atherogenic molecule namely heme oxygenase-1 in endothelial cells and all these data showed that C18-DOM is exhibiting aspirin-like effects. Moreover our in vivo studies showed that C18-DOM feeding slowed remarkably the progression of atherosclerosis. Our study demonstrated a novel biological effect of oceanic DOM, which has several important implications, including a possible therapeutic strategy for atherosclerosis.
authors.affiliation: Department of Surgery II, Faculty of Medicine, Kochi University, Japan.
authors.forename: Geethalakshmi
authors.initials: G
authors.lastname: Radhakrishnan
authors.forename: Morio
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Hironori
authors.initials: H
authors.lastname: Maeda
authors.forename: Aimi
authors.initials: A
authors.lastname: Nakagawa
authors.forename: Rajesh
authors.initials: R
authors.lastname: KatareGopalrao
authors.forename: Hironobu
authors.initials: H
authors.lastname: Okada
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nishimori
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Wariishi
authors.forename: Eiji
authors.initials: E
authors.lastname: Toda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Shiro
authors.initials: S
authors.lastname: Sasaguri
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism*; D015374:Biosensing Techniques; D002784:Cholesterol / Q000378:metabolism; D051545:Cyclooxygenase 1 / Q000737:chemistry / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D004800:Enzymes, Immobilized / Q000037:antagonists & inhibitors / Q000737:chemistry; D019007:P-Selectin / Q000037:antagonists & inhibitors; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D012623:Seawater / Q000737:chemistry*; D017539:Tunica Intima / Q000187:drug effects / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004800:Enzymes, Immobilized; D019007:P-Selectin; D002784:Cholesterol; D051545:Cyclooxygenase 1; D001241:Aspirin