Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis.
Activities of sphingomyelinase and ceramidase decreased in the liver in chronic toxic hepatitis and the balance between the levels of proapoptotic ceramide and antiapoptotic sphyngosine-1-phosphate shifts towards the latter substance. Pronounced changes in the qualitative and quantitative composition of fatty acids in the sphingomyelin cycle effector molecules were revealed.
Serebrov
V Yu
VY
Department of Biochemistry and Molecular Biology, Siberian State Medical University, Russian Ministry of Health, Tomsk, Russia. serebrov@ssmu.ru
Kuzmenko
D I
DI
Burov
P G
PG
Novitsky
S V
SV
D000818:Animals; D055572:Ceramidases / Q000378:metabolism; D002518:Ceramides / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D006521:Hepatitis, Chronic / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D008246:Lysophospholipids / Q000378:metabolism; D008297:Male; D051381:Rats; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D013109:Sphingomyelins / Q000378:metabolism*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism
D002518:Ceramides; D008246:Lysophospholipids; D013109:Sphingomyelins; C060506:sphingosine 1-phosphate; D013108:Sphingomyelin Phosphodiesterase; D055572:Ceramidases; D013110:Sphingosine