title: A crowdsourcing evaluation of the NIH chemical probes.
abstract: Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.
authors.affiliation: University of New Mexico Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA. toprea@salud.unm.edu
authors.forename: Tudor I
authors.initials: TI
authors.lastname: Oprea
authors.forename: Cristian G
authors.initials: CG
authors.lastname: Bologa
authors.forename: Scott
authors.initials: S
authors.lastname: Boyer
authors.forename: Ramona F
authors.initials: RF
authors.lastname: Curpan
authors.forename: Robert C
authors.initials: RC
authors.lastname: Glen
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Hopkins
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Lipinski
authors.forename: Garland R
authors.initials: GR
authors.lastname: Marshall
authors.forename: Yvonne C
authors.initials: YC
authors.lastname: Martin
authors.forename: Liliana
authors.initials: L
authors.lastname: Ostopovici-Halip
authors.forename: Gilbert
authors.initials: G
authors.lastname: Rishton
authors.forename: Oleg
authors.initials: O
authors.lastname: Ursu
authors.forename: Roy J
authors.initials: RJ
authors.lastname: Vaz
authors.forename: Chris
authors.initials: C
authors.lastname: Waller
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
authors.forename: Larry A
authors.initials: LA
authors.lastname: Sklar
mesh_terms: D016208:Databases, Factual; D003657:Decision Making; D055808:Drug Discovery / Q000191:economics / Q000379:methods* / Q000458:organization & administration / Q000592:standards; D015336:Molecular Probe Techniques / Q000592:standards / Q000639:trends*; D015335:Molecular Probes / Q000737:chemistry*; D009316:National Institutes of Health (U.S.); D054852:Small Molecule Libraries / Q000737:chemistry*; D014481:United States
chemical_list: D015335:Molecular Probes; D054852:Small Molecule Libraries