Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function.
OBJECTIVE
The Chronic Renal Insufficiency Cohort (CRIC) Study was established to examine risk factors for the progression of chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with CKD. We examined baseline demographic and clinical characteristics.


METHODS
Seven clinical centers recruited adults who were aged 21 to 74 yr and had CKD using age-based estimated GFR (eGFR) inclusion criteria. At baseline, blood and urine specimens were collected and information regarding health behaviors, diet, quality of life, and functional status was obtained. GFR was measured using radiolabeled iothalamate in one third of participants.


RESULTS
A total of 3612 participants were enrolled with mean age +/- SD of 58.2 +/- 11.0 yr; 46% were women, and 47% had diabetes. Overall, 45% were non-Hispanic white, 46% were non-Hispanic black, and 5% were Hispanic. Eighty-six percent reported hypertension, 22% coronary disease, and 10% heart failure. Mean body mass index was 32.1 +/- 7.9 kg/m(2), and 47% had a BP >130/80 mmHg. Mean eGFR was 43.4 +/- 13.5 ml/min per 1.73 m(2), and median (interquartile range) protein excretion was 0.17 g/24 h (0.07 to 0.81 g/24 h). Lower eGFR was associated with older age, lower socioeconomic and educational level, cigarette smoking, self-reported CVD, peripheral arterial disease, and elevated BP.


CONCLUSIONS
Lower level of eGFR was associated with a greater burden of CVD as well as lower socioeconomic and educational status. Long-term follow-up of participants will provide critical insights into the epidemiology of CKD and its relationship to adverse outcomes.
Lash
James P
JP
University of Illinois at Chicago, Department of Medicine/Section of Nephrology (MC 793), 820 South Wood Street, Chicago, IL 60612-7315, USA. jplash@uic.edu
Go
Alan S
AS
Appel
Lawrence J
LJ
He
Jiang
J
Ojo
Akinlolu
A
Rahman
Mahboob
M
Townsend
Raymond R
RR
Xie
Dawei
D
Cifelli
Denise
D
Cohan
Janet
J
Fink
Jeffrey C
JC
Fischer
Michael J
MJ
Gadegbeku
Crystal
C
Hamm
L Lee
LL
Kusek
John W
JW
Landis
J Richard
JR
Narva
Andrew
A
Robinson
Nancy
N
Teal
Valerie
V
Feldman
Harold I
HI
D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000150:complications* / Q000208:ethnology / Q000503:physiopathology; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011446:Prospective Studies; D011507:Proteinuria / Q000209:etiology / Q000503:physiopathology; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000208:ethnology / Q000503:physiopathology*; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D012923:Social Class; D014481:United States / Q000453:epidemiology; D055815:Young Adult