Autologous hematopoietic stem cell transplant in systemic sclerosis: quantitative high resolution computed tomography of the chest scoring.
OBJECTIVE
Using high resolution computed tomography (HRCT), to assess the lung involvement outcome after autologous hematopoietic stem cell transplant (AHSCT) in patients with scleroderma (systemic sclerosis, SSc).


METHODS
HCRT scans prospectively performed before (n = 9 patients) and after (n = 47) AHSCT were blindly reviewed by 2 independent investigators using the Wells score.


RESULTS
After a median 60 months' followup, the overall disease extent score from HCRT scans decreased from 10 (0-45) to 4 (0-36) (p = 0.04) 6 months after AHSCT, and thereafter increased up to 36 months and stabilized; the modified Rodnan skin score fell (p < 0.05).


CONCLUSIONS
The extent of SSc lung involvement on HRCT rapidly but transiently regressed after AHSCT.
Launay
David
D
Service de Médecine Interne, Hôpital Claude-Huriez, Université Lille 2, Lille, France.
Marjanovic
Zora
Z
de Bazelaire
Cedric
C
Florea
Laura
L
Zohar
Sarah
S
Keshtmand
Homah
H
Deligny
Christophe
C
de Raigniac
Axelle
A
Wells
Athol U
AU
Farge
Dominique
D
D000293:Adolescent; D000328:Adult; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000209:etiology; D012595:Scleroderma, Systemic / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult