Structure and concentration capacity of the kidneys in brattleboro rats under conditions of long-term vasopressin treatment.
The function and histochemistry of the kidney were studied in homozygous Brattleboro rats after 28-day treatment with exogenous arginine-vasopressin. The long-lasting effect of the hormone includes normalization of osmotic concentration, decrease in the number of b-glucuronidase granules in the medulla, and increasing content of hyaluronan in the interstitium. These changes promote physiological optimization of the antidiuretic reaction to vasopressin.
Ivanova
L N
LN
Novosibirsk State University; Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk.
Lavrinenko
V A
VA
Babina
A V
AV
Khegay
I I
II
D000818:Animals; D050034:Antidiuretic Agents / Q000494:pharmacology*; D001127:Arginine Vasopressin / Q000494:pharmacology*; D005966:Glucuronidase / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007679:Kidney Medulla / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011910:Rats, Brattleboro
D050034:Antidiuretic Agents; D001127:Arginine Vasopressin; D006820:Hyaluronic Acid; D005966:Glucuronidase