Perp and pemphigus: a disease of desmosome destabilization.
In this issue, Nguyen et al. demonstrate a role for Perp in desmosome assembly and trafficking and pemphigus IgG-mediated acantholysis, providing further insights into the complexity of desmosome structure and regulation.
Bektas
Meryem
M
Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599-7287, USA.
Rubenstein
David S
DS
D003896:Desmosomes / Q000378:metabolism* / Q000473:pathology*; D016147:Genes, Tumor Suppressor; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D010392:Pemphigus / Q000378:metabolism* / Q000473:pathology*; D021381:Protein Transport / Q000502:physiology
D008565:Membrane Proteins; C416404:PERP protein, human