Controlled release using mesoporous materials containing gate-like scaffoldings.
The use of gated mesoporous silica solids as suitable systems for controlled-release protocols is reviewed. These materials are based on mesoporous silica supports that can be prepared with tailor-made pores of around 2 - 10 nm and that show a very large specific surface area (up to 1200 m(2)/g), thus having a large load capacity. The solids can be additionally functionalised in the external surface with gate-like systems that can be opened on command to allow cargo release. Light, redox reactions, pH, temperature, polarity and enzyme-driven protocols are shown. The possible application in drug delivery protocols is discussed.
Aznar
Elena
E
Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro mixtoUniversidad Politécnica de Valencia-Universidad de Valencia, Spain.
Martínez-Máñez
Ramón
R
Sancenón
Félix
F
D003692:Delayed-Action Preparations / Q000493:pharmacokinetics*; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D008958:Models, Molecular; D049329:Nanostructures; D016062:Porosity; D012822:Silicon Dioxide
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012822:Silicon Dioxide