Adipose tissue-muscle interactions and the metabolic effects of n-3 LCPUFA - implications for programming effects of early diet.
Studies in adult animals as well as in humans have demonstrated beneficial effects of increased intake of n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) on lipid metabolism, obesity, and insulin sensitivity. The lipid composition of breast milk, and in particular, the role of n-3 LCPUFA in imprinting of metabolism and its hormonal control need clarification as far as the long-term beneficial effects of breastfeeding on health are concerned. In this respect, animal studies have brought inconclusive results. However, the involvement of adipose tissue-muscle interactions in the short term effects of n-3 LCPUFA during perinatal development, as well as the lasting effects of n-3 LCPUFA intake, are likely to occur and should be further investigated.
Janovska
Paul
P
Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Kopecky
Jan
J
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001942:Breast Feeding; D004032:Diet / Q000379:methods*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D006801:Humans; D007774:Lactation / Q000378:metabolism; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism*; D051381:Rats
D005231:Fatty Acids, Unsaturated