High transmissibility of the modern Beijing Mycobacterium tuberculosis in homeless patients of Japan.
A population-based study of Mycobacterium tuberculosis isolated from homeless tuberculosis patients was performed during 2002-2004 in Osaka City, Japan. The data show that the ancient Beijing subfamily was predominant, whereas clustered isolates based on refined variable number of tandem repeats genotyping (19 loci) mainly belonged to the modern Beijing subfamily, suggesting its increased transmissibility.
Wada
Takayuki
T
Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, 8-34 Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan. taka-wada@city.osaka.lg.jp
Fujihara
Sami
S
Shimouchi
Akira
A
Harada
Makoto
M
Ogura
Hisashi
H
Matsumoto
Sohkichi
S
Hase
Atsushi
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015373:Bacterial Typing Techniques / Q000379:methods; D016000:Cluster Analysis; D005260:Female; D005838:Genotype; D006703:Ill-Housed Persons; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D013045:Species Specificity; D020080:Tandem Repeat Sequences; D014376:Tuberculosis / Q000382:microbiology* / Q000635:transmission*