title: Amidine dications: isolation and [Fe]-hydrogenase-related hydrogenation.
abstract: This communication demonstrates the preparation, isolation, and full characterization of superelectrophilic salts based on amidine dications in organic solvent, as their triflate salts. These dications are highly activated toward regiospecific reaction with hydrogen gas under mild conditions in the presence of a metal catalyst (Pd/C), mimicking the behavior of the natural substrate, N(5),N(10)-methenyltetrahydromethanopterin, in the iron-sulfur cluster-free [Fe]-hydrogenase.
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Corr
authors.forename: Kirsty F
authors.initials: KF
authors.lastname: Gibson
authors.forename: Alan R
authors.initials: AR
authors.lastname: Kennedy
authors.forename: John A
authors.initials: JA
authors.lastname: Murphy
mesh_terms: D000478:Alkylation; D000578:Amidines / Q000138:chemical synthesis / Q000737:chemistry*; D001419:Bacteria / Q000737:chemistry; D001426:Bacterial Proteins / Q000737:chemistry; D032701:Biomimetics; D002384:Catalysis; D002412:Cations / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006859:Hydrogen / Q000737:chemistry*; D006864:Hydrogenase / Q000737:chemistry; D006865:Hydrogenation; D007506:Iron-Sulfur Proteins / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000578:Amidines; D001426:Bacterial Proteins; D002412:Cations; D007506:Iron-Sulfur Proteins; D006859:Hydrogen; C118830:iron hydrogenase; D006864:Hydrogenase