title: Factors that influence decisions by families to donate brain tissue for medical research.
abstract: Whilst mainstream transplant literature provides valuable insights into the influences on families to donate organs and tissues for transplant, the relevance of these findings in relation to organ donation for research remain speculative. The present study aims to expand the research donation literature, by exploring factors that influence a family's decision to donate brain tissue to neuroscience research. The verbal responses of the senior available next-of-kin (NOK), to the question of brain donation for research, are analysed. The donation rate was high (54%) over the 5-year-period. NOK relationship to the deceased, and post mortem interval were the main factors associated with a positive donation. Parents were most likely to donate and this may result from a lifetime of decision-making on behalf of the deceased. Also, the longer the interval between death of the potential donor and the question being asked, the greater the likelihood of donation.
authors.affiliation: Department of Pathology (D06), University of Sydney, Sydney, NSW, 2006, Australia. therese.garrick@gmail.com
authors.forename: Therese
authors.initials: T
authors.lastname: Garrick
authors.forename: Nina
authors.initials: N
authors.lastname: Sundqvist
authors.forename: Timothy
authors.initials: T
authors.lastname: Dobbins
authors.forename: Liza
authors.initials: L
authors.lastname: Azizi
authors.forename: Clive
authors.initials: C
authors.lastname: Harper
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D035843:Biomedical Research / Q000941:ethics; D003625:Data Collection; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009488:Neurosciences / Q000941:ethics; D020458:Third-Party Consent / Q000941:ethics; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000941:ethics; D055815:Young Adult