title: Normal range of human red blood cell acetylcholinesterase activity.
abstract: The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean +/- SD) was 0.74 +/- 0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope +0.0008 delta pH units/hour for each year; P < 0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.
authors.affiliation: Department of Animal Science, University of California-Davis, Davis, California 95616, USA.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Arrieta
authors.forename: Stephen A
authors.initials: SA
authors.lastname: McCurdy
authors.forename: John D
authors.initials: JD
authors.lastname: Henderson
authors.forename: Lee J
authors.initials: LJ
authors.lastname: Lefkowitz
authors.forename: Raven
authors.initials: R
authors.lastname: Reitstetter
authors.forename: Barry W
authors.initials: BW
authors.lastname: Wilson
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D055815:Young Adult
chemical_list: D000110:Acetylcholinesterase