title: Life-Threatening Anaphylactoid Reaction in an Acute Ischemic Stroke Patient With Intravenous rt-PA Thrombolysis, Followed by Successful Intra-Arterial Thrombolysis.
abstract: An anaphylactoid reaction to recombinant tissue plasminogen activator (rt-PA) is an uncommon but fatal complication. A 39-year-old man was admitted within 1 hour of the onset of a right hemispheric stroke. He was not taking any specific medication, including angiotensin-converting enzyme (ACE) inhibitors. A systemic anaphylactoid reaction developed immediately after rt-PA infusion. However, the symptoms were improved after treatment with a steroid and antihistamine. Subsequent intra-arterial thrombolytic therapy resulted in complete recanalization and clinical improvement. To our knowledge, this is the first report of a life-threatening anaphylactoid reaction after rt-PA treatment followed by successful intra-arterial thrombolytic therapy in a patient who had not taken an ACE inhibitor.
authors.affiliation: Department of Neurology, The Catholic University of Korea, Kang-nam St. Mary's Hospital, Seoul, Korea.
authors.forename: In-Serk
authors.initials: IS
authors.lastname: Park
authors.forename: A-Hyun
authors.initials: AH
authors.lastname: Cho
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Lee
authors.forename: Joong-Seok
authors.initials: JS
authors.lastname: Kim
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Lee
authors.forename: Yeong-In
authors.initials: YI
authors.lastname: Kim