title: Variation in genomic recombination rates among heterogeneous stock mice.
abstract: We used a large panel of pedigreed, genetically admixed house mice to study patterns of recombination rate variation in a leading mammalian model system. We found considerable inter-individual differences in genomic recombination rates and documented a significant heritable component to this variation. These findings point to clear variation in recombination rate among common laboratory strains, a result that carries important implications for genetic analysis in the house mouse.
authors.affiliation: Laboratory of Genetics, University of Wisconsin, Madison, 53706, USA.
authors.forename: Beth L
authors.initials: BL
authors.lastname: Dumont
authors.forename: Karl W
authors.initials: KW
authors.lastname: Broman
authors.forename: Bret A
authors.initials: BA
authors.lastname: Payseur
mesh_terms: D000818:Animals; D016678:Genome; D007700:Kinetics; D051379:Mice / Q000235:genetics*; D011995:Recombination, Genetic