title: Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with advanced stage endometriosis.
abstract: BACKGROUND
  Altered expression of endothelial nitric oxide synthase (eNOS) has been reported to be involved in the development of endometriosis. The genotypes of eNOS gene (NOS3) may be responsible for variation in its enzymatic activity as well as plasma concentration of nitric oxide. The Glu298Asp polymorphism of the NOS3 may modulate angiogenesis and influence individual susceptibility to endometriosis. This study was designed to evaluate the association between the Glu298Asp polymorphism of the NOS3 and advanced stage endometriosis.
  
  
  METHODS
  This study consisted of 299 women with advanced stage endometriosis and 459 control women without endometriosis in a Korean population. Genotyping results of the Glu298Asp polymorphism of the NOS3 were analyzed between the endometriosis and control group.
  
  
  RESULTS
  The genotypic frequencies were significantly different between women with and without endometriosis. The frequency of the non-GG genotype (GT + TT) was higher in the endometriosis group than in the control group (P = 0.001).
  
  
  CONCLUSIONS
  These findings suggest that the T allele, encoding aspartic acid, of the Glu298Asp polymorphism of the NOS3 may be associated with advanced stage endometriosis in the Korean population.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-ku, Seoul 110-744, South Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Kim
authors.forename: Seung Yup
authors.initials: SY
authors.lastname: Ku
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Gyoung Hoon
authors.initials: GH
authors.lastname: Lee
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Jong Mee
authors.initials: JM
authors.lastname: Kim
authors.forename: Taek Hoo
authors.initials: TH
authors.lastname: Lee
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III