title: Characterization of Japanese standards for myocardial sympathetic and metabolic imaging in comparison with perfusion imaging.
abstract: OBJECTIVE
  The standard patterns of myocardial radiotracer distribution of (123)I-metaiodobenzylguanidine (MIBG) and (123)I-beta-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) should be defined in a Japanese population. The purpose of this study was to present and provide data on the characteristics of MIBG and BMIPP with respect to myocardial single photon emission computed tomography.
  
  
  METHODS
  The normal database included (123)I-MIBG and (123)I-BMIPP imaging and a (99m)Tc-sestamibi/tetrofosmin myocardial perfusion study. The projection images were transferred by digital imaging and communications in medicine (DICOM) format and reconstructed and analyzed with polar maps.
  
  
  RESULTS
  The projection data from multiple centers were successfully transferred to a common format for SPECT reconstruction. When the average values were analyzed using a 17-segment model, MIBG uptake in the inferior and apical wall appeared to be slightly lower than anterior uptake (P < 0.05). The inferior and apical uptake of MIBG has a larger standard deviation (10.7 units in males, 12.6 units in females). BMIPP uptakes in the septal wall have higher than that of (99m)Tc-tracer uptake (P < 0.05).
  
  
  CONCLUSIONS
  Myocardial sympathetic nerve and metabolic scintigraphy data that were specific for the Japanese population were generated and found to be different from that of perfusion tracers. The normal database can serve as a standard for nuclear cardiology work conducted in Japan.
authors.affiliation: Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 920-8641, Japan. smatsuo@nmd.m.kanazawa-u.ac.jp
authors.forename: Shinro
authors.initials: S
authors.lastname: Matsuo
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakajima
authors.forename: Shohei
authors.initials: S
authors.lastname: Yamashina
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sakata
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Momose
authors.forename: Jun
authors.initials: J
authors.lastname: Hashimoto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kumita
authors.forename: Masaya
authors.initials: M
authors.lastname: Kawano
authors.forename: Koichi
authors.initials: K
authors.lastname: Okuda
mesh_terms: D019797:3-Iodobenzylguanidine / Q000378:metabolism; D000368:Aged; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000294:innervation*; D006801:Humans; D007462:Iodobenzenes / Q000378:metabolism; D007564:Japan; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009206:Myocardium / Q000378:metabolism*; D009683:Nuclear Medicine; D012958:Societies, Scientific; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005227:Fatty Acids; D007462:Iodobenzenes; C049338:iodofiltic acid; D019797:3-Iodobenzylguanidine