Recent advances in T-cell regulation relevant to inflammatory dermatopathology.
Inflammatory dermatoses encompass an enormous area of dermatopathology. Our understanding of the subject comes from combination of histopathological observations and relevant clinical information. Diagnoses are generally reached at the hematoxylin and eosin (H&E) level by using various pattern recognition approaches including one devised by Dr Ackerman et al. Recent advances in cell biology and immunology especially the field of T-cell regulation shed light to the intricate cellular interactions, associations and connect to inflammatory dermatopathology. This review attempts to identify and put into context the most significant advances in cellular biology relevant to the topic. Most of the information presented here is not necessarily relevant to our regular work at the moment; however, the new information will surely channel into our practice to provide a better, more accurate, semi-individualized diagnostic approach in the not too far future.
Karai
Laszlo J
LJ
Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. lkarai1@yahoo.com
Bergfeld
Wilma F
WF
D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D003872:Dermatitis / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology