Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group.
Regioselective synthesis of methylated epigallocatechin gallate from epigallocatechin was accomplished using a 2-nitrobenzenesulfonyl (Ns) group as a protecting group for phenols. This methodology provided several methylated catechins, which are naturally scarce catechin derivatives.
Aihara
Yoshiyuki
Y
School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Yoshida
Atsusi
A
Furuta
Takumi
T
Wakimoto
Toshiyuki
T
Akizawa
Toshifumi
T
Konishi
Motomi
M
Kan
Toshiyuki
T
D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002625:Chemistry, Organic / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism; D008745:Methylation; D051379:Mice; D008956:Models, Chemical; D011994:Recombinant Proteins / Q000737:chemistry; D013237:Stereoisomerism; D013662:Tea
D011994:Recombinant Proteins; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; D020783:Matrix Metalloproteinase 7; D020781:Matrix Metalloproteinase 1