Suzuki-miyaura and sonogashira coupling of 6-chloropurines and -nucleosides in water.
A general protocol is reported for the efficient Suzuki-Miyaura and the copper-free Sonogashira coupling of unprotected 6-chloropurines and unprotected beta-d-ribofuranosyl-6-chloropurine in water or in water/n-butanol utilizing Na(2)PdCl(4) and a disulfonated and highly water-soluble fluorenylphosphine (cataCXium F sulf).
Pschierer
Jan
J
Anorganische Chemie im Zintl-Institut, TU Darmstadt, Petersenstrasse 18, 64287 Darmstadt, Germany.
Plenio
Herbert
H