Homology modeling of GPCRs.
Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.
Simms
John
J
Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
Hall
Nathan E
NE
Lam
Polo H C
PH
Miller
Laurence J
LJ
Christopoulos
Arthur
A
Abagyan
Ruben
R
Sexton
Patrick M
PM
D000595:Amino Acid Sequence; D019295:Computational Biology; D030562:Databases, Protein; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid
D018343:Receptors, Adrenergic, beta-2; D043562:Receptors, G-Protein-Coupled