Anticoagulant effects of a complex of high molecular weight heparin and arginine.
Heparin forms a complex compound with arginine in a pure system, which was shown by biochemical methods. A method for obtaining the complex in vitro has been developed. At arginine/heparin molar ratio of 3:1 the complex exhibited anticoagulant, antiplatelet, and fibrin-depolymerization activities. High fibrin-depolymerization and anticoagulant activities were documented in the blood of animals 10 min after intravenous injection of the arginine-heparin complex, in contrast to the picture after injection of the complex components (heparin and arginine) alone.
Lyapina
L A
LA
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov State Moscow University, Russia. lyapinal@mail.ru
Obergan
T Yu
TY
Pastorova
V E
VE
D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001120:Arginine / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005337:Fibrin / Q000737:chemistry / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D006493:Heparin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D008970:Molecular Weight; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D005337:Fibrin; D006493:Heparin; D001120:Arginine