The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans.
Cancer development is often associated with the lack of specific and efficient recognition of tumor cells by the immune system. Natural killer (NK) cells are lymphocytes of the innate immune system that participate in the elimination of tumors. We report the identification of a tumor cell surface molecule that binds NKp30, a human receptor which triggers antitumor NK cell cytotoxicity and cytokine secretion. This previously unannotated gene belongs to the B7 family and, hence, was designated B7-H6. B7-H6 triggers NKp30-mediated activation of human NK cells. B7-H6 was not detected in normal human tissues but was expressed on human tumor cells, emphasizing that the expression of stress-induced self-molecules associated with cell transformation serves as a mode of cell recognition in innate immunity.
Brandt
Cameron S
CS
Molecular and Cell Based Discovery, ZymoGenetics Inc., Seattle, WA 98102, USA.
Baratin
Myriam
M
Yi
Eugene C
EC
Kennedy
Jacob
J
Gao
Zeren
Z
Fox
Brian
B
Haldeman
Betty
B
Ostrander
Craig D
CD
Kaifu
Tomonori
T
Chabannon
Christian
C
Moretta
Alessandro
A
West
Robert
R
Xu
Wenfeng
W
Vivier
Eric
E
Levin
Steven D
SD
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D060887:B7 Antigens; D018122:B7-1 Antigen / Q000235:genetics / Q000276:immunology*; D045744:Cell Line, Tumor / Q000276:immunology; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007141:Immunoglobulin Fc Fragments / Q000235:genetics / Q000276:immunology; D020014:K562 Cells; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D008024:Ligands; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D055628:Natural Cytotoxicity Triggering Receptor 3 / Q000235:genetics / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology
D015703:Antigens, CD; D000954:Antigens, Surface; D060887:B7 Antigens; D018122:B7-1 Antigen; D007141:Immunoglobulin Fc Fragments; D008024:Ligands; C431710:NCR3 protein, human; C542363:NCR3LG1 protein, human; D055628:Natural Cytotoxicity Triggering Receptor 3; D011993:Recombinant Fusion Proteins