title: Highly efficient asymmetric trans-selective aziridination of diazoacetamides and N-Boc-imines catalyzed by chiral Brønsted acids.
abstract: A clean and fast (10 min) aziridination of diazoacetamides with N-Boc-imines, as well as N-Cbz-imines, catalyzed by chiral phosphoric acid (R)-5g in DCM at room temperature was developed. The excellent yields (89-97%), diastereoselectivities (trans/cis > 50:1), chemoselectivities (3:4 = >95:5), and enantioselectivities (88-98% ee) were achieved in the reaction.
authors.affiliation: Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, 21 Nanyang link, Singapore 637371, Singapore.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zeng
authors.forename: Xin
authors.initials: X
authors.lastname: Zeng
authors.forename: Zhenjiang
authors.initials: Z
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhong