title: Molecular adaptation in RNA complexes.
abstract: In this issue, Batey and colleagues show that the purine riboswitch is able to bind purine analogs by exploiting various strategies, including lateral shifts of the bases and, most importantly, changes in ligand tautomeric form.
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, CNRS, 15 rue René Descartes, 67084 Strasbourg, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Fritsch
authors.forename: Eric
authors.initials: E
authors.lastname: Westhof
mesh_terms: D020121:5' Untranslated Regions; D000225:Adenine / Q000737:chemistry / Q000378:metabolism; D052157:Aptamers, Nucleotide / Q000737:chemistry; D020029:Base Pairing; D001483:Base Sequence; D001665:Binding Sites; D006147:Guanine / Q000737:chemistry / Q000378:metabolism; D006860:Hydrogen Bonding; D008024:Ligands; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011687:Purines / Q000737:chemistry / Q000378:metabolism*; D012313:RNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D020121:5' Untranslated Regions; D052157:Aptamers, Nucleotide; D008024:Ligands; D011687:Purines; D006147:Guanine; D012313:RNA; D000225:Adenine