Synchronization and clustering of synthetic genetic networks: a role for cis-regulatory modules.
The effect of signal integration through cis-regulatory modules (CRMs) on synchronization and clustering of populations of two-component genetic oscillators coupled with quorum sensing is investigated in detail. We find that the CRMs play an important role in achieving synchronization and clustering. For this, we investigate six possible cis-regulatory input functions with AND, OR, ANDN, ORN, XOR, and EQU types of responses in two possible kinds of cell-to-cell communications: activator-regulated communication (i.e., the autoinducer regulates the activator) and repressor-regulated communication (i.e., the autoinducer regulates the repressor). Both theoretical analysis and numerical simulation show that different CRMs drive fundamentally different cellular patterns, such as complete synchronization, various cluster-balanced states and several cluster-nonbalanced states.
Zhang
Jiajun
J
School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China.
Yuan
Zhanjiang
Z
Zhou
Tianshou
T
D000465:Algorithms; D002450:Cell Communication / Q000235:genetics*; D003198:Computer Simulation; D025461:Feedback, Physiological; D053263:Gene Regulatory Networks; D008957:Models, Genetic; D010507:Periodicity; D053038:Quorum Sensing