Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease.
We examined the effects of voluntary (16 weeks of wheel running) and forced (16 weeks of treadmill running) exercise on memory-related behavior, hippocampal volume, thioflavine-stained plaque number, and soluble Abeta levels in brain tissue in the Tg2576 mouse model of Alzheimer's disease (AD). Voluntary running animals spent more time investigating a novel object in a recognition memory paradigm than all other groups. Also, voluntary running animals showed fewer thioflavine S stained plaques than all other groups, whereas forced running animals showed an intermediate number of plaques between voluntary running and sedentary animals. Both voluntary and forced running animals had larger hippocampal volumes than sedentary animals. However, levels of soluble Abeta-40 or Abeta-42 did not significantly differ among groups. The results indicate that voluntary exercise may be superior to forced exercise for reducing certain aspects of AD-like deficits - i.e., plaque deposition and memory impairment, in a mouse model of AD.
Yuede
Carla M
CM
Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave., St. Louis, MO 63110, USA. yuedec@psychiatry.wustl.edu
Zimmerman
Scott D
SD
Dong
Hongxin
H
Kling
Matthew J
MJ
Bero
Adam W
AW
Holtzman
David M
DM
Timson
Benjamin F
BF
Csernansky
John G
JG
D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D052160:Benzothiazoles; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D009929:Organ Size; D010446:Peptide Fragments / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*; D058255:Protease Nexins; D011897:Random Allocation; D011956:Receptors, Cell Surface / Q000235:genetics; D021641:Recognition, Psychology / Q000502:physiology; D013844:Thiazoles / Q000378:metabolism; D013997:Time Factors
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D052160:Benzothiazoles; D010446:Peptide Fragments; D058255:Protease Nexins; D011956:Receptors, Cell Surface; D013844:Thiazoles; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); C009462:thioflavin T