title: Silicone migration and granuloma formation.
abstract: The use of liquid injectable silicone for soft tissue augmentation is a controversial practice within the medical community. Injectable silicone has been illegally obtained, adulterated, and abused by nonmedical practitioners for the last five decades. Injection of silicone can result in catastrophic consequences including death, when grossly abused. Opponents of this practice cite the many serious adverse events that have occurred with its use both legally and illegally. Proponents argue that employment of a stringent regimen of use as well as a highly purified medical grade product allow for a safe utilization of the material. Both sides agree that this practice calls for a high degree of knowledge and technical skill. A continued evaluation of the long-term safety of this material is necessary before a consensus can be reached. Herein, we report a case of illegal administration of injectable silicone resulting in product migration accompanied by a granulomatous response. Further, the literature that both supports and refutes the practice of silicone injection is reviewed.
authors.affiliation: Department of Dermatology, Tulane University Health Sciences Center, New Orleans, LA 70112-2699, USA.
authors.forename: Mary D
authors.initials: MD
authors.lastname: Altmeyer
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Anderson
authors.forename: Alun R
authors.initials: AR
authors.lastname: Wang
mesh_terms: D000328:Adult; D002081:Buttocks / Q000473:pathology*; D003357:Cosmetic Techniques / Q000009:adverse effects*; D004129:Dimethylpolysiloxanes / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007279:Injections, Subcutaneous / Q000379:methods; D012828:Silicones / Q000009:adverse effects
chemical_list: D004129:Dimethylpolysiloxanes; D012828:Silicones