Retinoblastoma, an inside job.
Why are some cell types more prone to transformation than others? In this issue, Xu et al. (2009) show that retinoblastoma cells co-opt several intrinsic features of cone photoreceptors for their survival and growth.
Bremner
Rod
R
Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada. rbremner@uhnres.utoronto.ca
D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D006801:Humans; D051379:Mice; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D012175:Retinoblastoma / Q000378:metabolism*; D047491:Retinoid X Receptor gamma / Q000378:metabolism
D047491:Retinoid X Receptor gamma; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2