The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target.
Nuclear factor-kappaB (NF-kappaB) is a key transcriptional factor family that consists of five members in mammalian cells, including NF-kappaB1 (p50), NF-kappaB2 (p52), RelA (p65), RelB and c-Rel. NF-kappaB is implicated in multiple physiological and pathological processes, including cell proliferation and differentiation, inflammatory and immune response, cell survival and apoptosis, cellular stress reactions and tumorigenesis. Recent studies by our group and others have highlighted the novel functions of the p50 protein. In this review, we will focus on the regulation and functions of NF-kappaB p50.
Yu
Yonghui
Y
Open Laboratory for Oversea Scientists, Center for Medical Research, Wuhan University, 115 Donghu Rd., Wuhan, Hubei 430071, China.
Wan
Yu
Y
Huang
Chuanshu
C
D017209:Apoptosis / Q000502:physiology; D018797:Cell Cycle Proteins / Q000096:biosynthesis; D049109:Cell Proliferation; D016503:Drug Delivery Systems; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008954:Models, Biological; D052002:NF-kappa B p50 Subunit / Q000096:biosynthesis / Q000502:physiology* / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D009687:Nuclear Proteins / Q000096:biosynthesis; D000097642:GADD45 Proteins
D018797:Cell Cycle Proteins; D052002:NF-kappa B p50 Subunit; D009687:Nuclear Proteins; C439070:GADD45A protein, human; D000097642:GADD45 Proteins