Celiac disease-related antibodies in Italian children with epilepsy.
Reports differ on the association between epilepsy and celiac disease, an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. In this study, 272 Italian children with epilepsy and 300 healthy children were screened for anti-gliadin and anti-transglutaminase immunoglobulin A and G; positive and borderline samples were tested for the presence of anti-endomysium antibodies. The prevalence of antibodies related to celiac disease was comparable to that of healthy controls. In keeping with this observation, Italian epileptic children should not be considered a group at risk for celiac disease.
Giordano
Lucio
L
Pediatric Neuropsychiatric Division, City Hospital of Brescia, Brescia, Italy.
Valotti
Monica
M
Bosetti
Adonella
A
Accorsi
Patrizia
P
Caimi
Luigi
L
Imberti
Luisa
L
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000150:complications / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D004827:Epilepsy / Q000097:blood / Q000150:complications / Q000276:immunology*; D005260:Female; D005903:Gliadin / Q000097:blood / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007223:Infant; D007558:Italy; D008297:Male; D012307:Risk Factors; D011503:Transglutaminases / Q000097:blood / Q000276:immunology*
D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin; D011503:Transglutaminases