title: Antihypoxants, thiasolo[5,4-b]indole derivatives, increase exercise performance in rats and mice.
abstract: The actoptrotective activity of 12 new antihypoxants of the thiasolo[5,4-b]indole series was studied on the model of treadmill running until exhaustion 1 and 24 h after intraperitoneal injection. Highly active compounds more effective than the reference drugs bemithyl and phenamine were found. They increased exercise performance 1 or 24 h after injection or maintained high performance throughout 24 h.
authors.affiliation: Department of Pharmacology, S. M. Kirov Russian Military Medical Academy, St. Petersburg, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Marysheva
authors.forename: P D
authors.initials: PD
authors.lastname: Shabanov
mesh_terms: D000818:Animals; D000860:Hypoxia / Q000188:drug therapy*; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D007211:Indoles; D013844:Thiazoles