title: Lack of association between serum transforming growth factor-beta 1 and cancer mortality risk in a nested case-control study in Japan.
abstract: We examined the potential role of serum TGF-beta 1 levels to predict cancer mortality risk in a nested case-control study within a large prospective cohort of middle-aged and elderly Japanese subjects. The cases were 893 persons who provided blood samples at baseline and subsequently died of cancer from all sites during the follow-up period. A total of 2,824 subjects were selected from the main study as controls, matched with the cases for sex, age and study area. Serum TGF-beta 1 levels were measured using a quantitative sandwich enzyme immunoassay. The odds ratios and 95% confidence intervals for each quartile were calculated using a conditional logistic regression model. Mean serum TGF-beta 1 levels were approximately 36 ng/ml in both cases and controls, with no significant difference . Overall, serum TGF-beta 1 levels were not associated with total cancer mortality after adjustment for potential confounding factors like age, body mass index or cigarette smoking. Serum TGF-beta 1 levels may thus not be associated with cancer mortality risk in apparently health individuals.
authors.affiliation: Dept of Public Health, Aichi Medical University School of Medicine, Aichi, Japan. linys@aichi-med-u.ac.jp
authors.forename: Yingsong
authors.initials: Y
authors.lastname: Lin
authors.forename: Kei
authors.initials: K
authors.lastname: Nakachi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Shogo
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Yagyu
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inaba
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tajima
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015986:Confounding Factors, Epidemiologic; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000401:mortality*; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D053773:Transforming Growth Factor beta1