CNS regeneration: only on one condition.
The mammalian CNS is usually not capable of regeneration. However, conditioning dorsal root ganglion neurons by first lesioning their peripheral axons allows for regeneration of their central axons later on within the spinal cord. New work shows that, even if the sequence of lesioning is reversed, regeneration through the CNS lesion can rapidly occur under certain conditions.
Silver
Jerry
J
Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. jxs10@po.cwru.edu
D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D002490:Central Nervous System / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D005727:Ganglia, Spinal / Q000502:physiology* / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats; D011984:Sensory Receptor Cells / Q000502:physiology* / Q000648:ultrastructure