title: Nuclear pore complex biogenesis.
abstract: Nuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold of the NPC and auxiliary factors in the assembly of this large macromolecular complex, and connections between NPC maintenance, NPC turnover, and aging of the cell.
authors.affiliation: Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Javier
authors.initials: J
authors.lastname: Fernandez-Martinez
authors.forename: Michael P
authors.initials: MP
authors.lastname: Rout
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D001203:Ascomycota / Q000378:metabolism; D001230:Aspergillus / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D009685:Nuclear Envelope / Q000378:metabolism; D022022:Nuclear Pore / Q000737:chemistry* / Q000378:metabolism; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D010539:Permeability; D012441:Saccharomyces cerevisiae / Q000378:metabolism
chemical_list: D028861:Nuclear Pore Complex Proteins