Hyper-recombination, diversity, and antibiotic resistance in pneumococcus.
Streptococcus pneumoniae is a pathogen of global importance that frequently transfers genetic material between strains and on occasion across species boundaries. In an analysis of 1930 pneumococcal genotypes from six housekeeping genes and 94 genotypes from related species, we identified mosaic genotypes representing admixture between populations and found that these were significantly associated with resistance to several classes of antibiotics. We hypothesize that these observations result from a history of hyper-recombination, which means that these strains are more likely to acquire both divergent genetic material and resistance determinants. This could have consequences for the reemergence of drug resistance after pneumococcal vaccination and also for our understanding of diversification and speciation in recombinogenic bacteria.
Hanage
William Paul
WP
Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK. w.hanage@imperial.ac.uk
Fraser
Christophe
C
Tang
Jing
J
Connor
Thomas Richard
TR
Corander
Jukka
J
D000483:Alleles; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D001499:Bayes Theorem; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial; D014644:Genetic Variation; D005838:Genotype; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics*
D000900:Anti-Bacterial Agents; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines