title: [FHIT--tumor suppressor protein involved in induction of apoptosis and cell cycle regulation].
abstract: The fragile histidine triad (Fhit) protein is a diadenosine triphosphate hydrolase belonging to the histidine triad family of nucleotide-binding proteins. Fhit is a tumor suppressor protein which plays an important role in pro-apoptotic signalling, cell cycle control and sensitivity to DNA damaging agents. The Ap3A--hydrolase activity of Fhit is not required for exertion of its tumor suppressor function. The FHIT gene is located in FRA3B region--the most common fragile site in the human genome. Loss of FHIT is observed in a variety of tumors and in premalignant states. Re-expression of FHIT in human cancer cells leads to inhibition of tumorogenecity and restoration of caspase-dependent apoptosis. Viral-mediated FHIT gene therapy induces apoptosis and suppresses tumors in preclinical models. Therefore, treatment with the FHIT gene may constitute a novel clinical approach for gene therapy of human cancers.
authors.affiliation: Zakład Chemii Bioorganicznej, Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk, Lódź.
authors.forename: Róza
authors.initials: R
authors.lastname: Pecherzewska
authors.forename: Barbara
authors.initials: B
authors.lastname: Nawrot
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology*; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D009363:Neoplasm Proteins / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D011230:Precancerous Conditions / Q000235:genetics; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase