Predictive risk factors of seizure-related injury in persons with epilepsy.
OBJECTIVE
The clinical risk factors for seizure-related injuries (SRI) in adult persons with epilepsy (PWE) were studied and analyzed to develop a predictive model.


METHODS
We enrolled 300 consecutive cases from three epilepsy clinics in Northeast, Thailand. Subjects were eligible if reported to have at least one seizure attack during the past 12 months. Face-to-face questionnaire was used to evaluate SRI, baseline characteristics and other seizure-related variables.


RESULTS
There were 247 and 91 PWE who met a criterion and had SRI, respectively. By multivariate logistic regression method, GTC seizure type, having history of seizure attacks at least 12 times/year, and daytime seizure were significant risk factors of having SRI with odds ratio of 2.376, 2.460, and 3.562, respectively. We developed the predictive model for having SRI in PWE and it gave 90.3% sensitivity and 46.7% specificity on the occurrence of SRI. The estimated probability of SRI can be found online at http://sribykku.webs.com/.


CONCLUSIONS
The significant predictive factors for SRI in PWE were the occurrence of GTCs, seizures at least 12 times/year or daytime seizures. Clinicians or PWE can easily evaluate the risk of having SRI in individuals by the online predictive model.
Tiamkao
Somsak
S
Division of Neurology, Department of Medicine, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. somtia@kku.ac.th
Sawanyawisuth
Kittisak
K
Asawavichienjinda
Thanin
T
Yaudnopakao
Prapun
P
Arunpongpaisal
Suwanna
S
Phuttharak
Warinthorn
W
Auevitchayapat
Narong
N
Vannaprasaht
Suda
S
Tiamkao
Siriporn
S
Phunikhom
Kutcharin
K
Chaiyakum
Aporanee
A
Saengsuwan
Jiamjit
J
Jitpimolmard
Suthipun
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D020407:Internet; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D017440:Photoperiod; D012307:Risk Factors; D012640:Seizures / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D013997:Time Factors; D014947:Wounds and Injuries / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D055815:Young Adult
D000927:Anticonvulsants