Recent advances in synthesis of PAR ligands as therapeutic strategy for inflammatory diseases.
Several studies have been published on discovering involvement of PARs receptors in a number of disease states, including cancer and inflammation of the cardiovascular, respiratory, musculoskeletal, gastrointestinal and nervous systems. This mini-review will focus on recent advances in the synthesis of PAR ligands highlighting their therapeutic potential in the treatment of various inflammatory diseases.
Severino
B
B
Department of Pharmaceutical and Toxicological Chemistry, University of Naples Federico II, via D. Montesano 49, -80131 Naples, Italy.
Santagada
V
V
Perissutti
E
E
Fiorino
F
F
Frecentese
F
F
De Angelis
F
F
Esposito
A
A
Caliendo
G
G
D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism*; D008024:Ligands; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D044462:Receptors, Proteinase-Activated / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000378:metabolism
D006571:Heterocyclic Compounds; D008024:Ligands; D009930:Organic Chemicals; D044462:Receptors, Proteinase-Activated