title: Handedness does not predict side of onset of motor symptoms in Parkinson's disease.
abstract: This study focused on the relationship between the asymmetry of initial motor symptoms of Parkinson's disease (PD) and premorbid handedness of patients. Structural equation modeling has been used for this purpose. The survey consisting of validated items measuring handedness and questions related to side of occurrence of initial symptoms was administered to 472 patients with PD [277 men, 195 women, mean age 66.5 (9.3), mean duration of the disease 10 (6.1) years]. The unidimensional model of handedness fits the data well (chi(2) = 37.86, df = 20, P = 0.009, Root Mean Square Error of Approximation = 0.044, Comparative Fit Index = 1.00, Standardized Root Mean Square Residual = 0.042) and side of initial motor symptoms is not significantly related to the factor of handedness (r =0.11, SE = 0.07, P = 0.14). In contrast to several other studies, the results indicate that the side of first occurrence of PD signs cannot be predicted from premorbid handedness of patients.
authors.affiliation: Department of Kinanthropology, Charles University in Prague, Czech Republic. stochl@ftvs.cuni.cz
authors.forename: Jan
authors.initials: J
authors.lastname: Stochl
authors.forename: Knut A
authors.initials: KA
authors.lastname: Hagtvet
authors.forename: Hana
authors.initials: H
authors.lastname: Brozová
authors.forename: Jirí
authors.initials: J
authors.lastname: Klempír
authors.forename: Jan
authors.initials: J
authors.lastname: Roth
authors.forename: Evzen
authors.initials: E
authors.lastname: Růzicka
mesh_terms: D017668:Age of Onset; D000368:Aged; D001526:Behavioral Symptoms / Q000209:etiology*; D016009:Chi-Square Distribution; D004185:Disability Evaluation; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D020734:Parkinsonian Disorders / Q000150:complications*; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires