title: Structural characteristics and properties of silk fibroin/poly(lactic acid) blend films.
abstract: This paper describes the preparation and characterization of blend films composed of regenerated silk fibroin (SF) and poly(lactic acid) (PLA). FT-IR and XRD of the SF/PLA blend films with different ratios indicated that the secondary structural transition of SF from Silk I to Silk II was induced upon blending with PLA. The effects of SF/PLA blend ratios on the mechanical and physical properties of the blend films were investigated. Compared to pure SF film, the mechanical and thermal properties of the blend films were improved, and surface hydrophilicity and swelling capacity decreased due to the secondary structural transition of SF to Silk II. Among the blend films with different ratios, the SF/PLA blend film with 7 wt% PLA content showed excellent mechanical properties. Meanwhile, the BSA adsorption amount on the blend film increased with the increase of PLA content. In vitro cell adhesion test showed that the blend film was a good matrix for the growth of L929 mouse fibroblast cells. Consequently, controlling the PLA content in the SF film can improve the mechanical and physical properties of the SF film and provide a promising opportunity to widen potential application of SF in the biomaterials field.
authors.affiliation: The Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Xiasha Higher Education Zone, Zhejiang Sci-Tech University, Hangzhou, 310018, PR China.
authors.forename: Hailin
authors.initials: H
authors.lastname: Zhu
authors.forename: Xinxing
authors.initials: X
authors.lastname: Feng
authors.forename: Huapeng
authors.initials: H
authors.lastname: Zhang
authors.forename: Yuhai
authors.initials: Y
authors.lastname: Guo
authors.forename: Jiazhong
authors.initials: J
authors.lastname: Zhang
authors.forename: Jianyong
authors.initials: J
authors.lastname: Chen
mesh_terms: D000327:Adsorption; D000818:Animals; D012831:Bombyx / Q000737:chemistry*; D002417:Cattle; D002460:Cell Line; D049109:Cell Proliferation; D055119:Elastic Modulus; D005347:Fibroblasts / Q000166:cytology; D005349:Fibroins / Q000737:chemistry* / Q000302:isolation & purification; D019344:Lactic Acid / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013718:Tensile Strength; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D011091:Polyesters; D011108:Polymers; D014867:Water; D012710:Serum Albumin, Bovine; D019344:Lactic Acid; C033616:poly(lactide); D005349:Fibroins