title: Impulsive and compulsive behaviors in Parkinson's disease.
abstract: Antiparkinson therapy can be the primary cause of a range of nonmotor symptoms that include a set of complex disinhibitory psychomotor pathologies and are linked by their repetitive, reward or incentive-based natures. These behaviors relate to aberrant or excessive dopamine receptor stimulation and encompass impulse control disorders (ICDs), punding, and the dopamine dysregulation syndrome (DDS). Common ICDs include pathological gambling, hypersexuality, compulsive eating, and compulsive buying. This review focuses on the phenomenology, epidemiology, and methods to identify and rate these disorders. The management of dopaminergic drug-related compulsive behaviors is discussed in the light of the current understanding of the neurobiological substrate of these disorders.
authors.affiliation: Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia. Andrew.Evans@mh.org.au
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Evans
authors.forename: Antonio P
authors.initials: AP
authors.lastname: Strafella
authors.forename: Daniel
authors.initials: D
authors.lastname: Weintraub
authors.forename: Mark
authors.initials: M
authors.lastname: Stacy
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003192:Compulsive Behavior / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D046690:Deep Brain Stimulation; D004198:Disease Susceptibility; D004298:Dopamine / Q000502:physiology; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005715:Gambling; D006801:Humans; D007175:Impulsive Behavior / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D008032:Limbic System / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy / Q000523:psychology*; D015995:Prevalence; D012201:Reward; D012725:Sexual Behavior / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D004298:Dopamine