title: Minimally invasive surgical technique and enamel matrix derivative in intrabony defects: 2. Factors associated with healing outcomes.
abstract: This case cohort study was designed to evaluate the healing response of a minimally invasive surgical technique (MIST) in combination with enamel matrix derivative (EMD) in isolated deep intrabony defects. Forty deep intrabony defects were surgically accessed with the MIST This technique was designed to limit the flap extent and reflection to reduce surgical trauma and increase flap stability. EMD was applied on the dried root surfaces. Surgery was performed with the aid of an operating microscope and microsurgical instruments. The 1-year clinical attachment level gain was 4.9 +/- 1.7 mm. Seventy percent of defects gained > or = 4 mm. Clinical attachment level gain was significantly associated with the depth of the three-wall component of the defect, with the intraoperative bleeding tendency of the defect, and with its interaction with the baseline amount of bone loss. Defect morphology and bleeding tendency seem to influence clinical outcomes from the use of MIST in combination with EMD.
authors.affiliation: Accademia Toscana di Ricerca Odontostomatologica (ATRO), Florence, Italy. studiocortellini@cortellini.191.it
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Cortellini
authors.forename: Giovanpaolo
authors.initials: G
authors.lastname: Pini-Prato
authors.forename: Michele
authors.initials: M
authors.lastname: Nieri
authors.forename: Maurizio S
authors.initials: MS
authors.lastname: Tonetti
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery*; D015331:Cohort Studies; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000601:surgery; D005889:Gingival Recession / Q000601:surgery; D006801:Humans; D008297:Male; D008866:Microsurgery / Q000295:instrumentation / Q000379:methods; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D013524:Surgical Flaps; D014092:Tooth Root / Q000187:drug effects; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins