title: Etiology and site of temporal lobe epilepsy influence postictal cytokine release.
abstract: Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1beta, IL-6 and TNFalpha in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying factors. Serum levels of IL-1beta, IL-6 and TNFalpha were quantified by ELISA at baseline as well as immediately, 1h and 24h after a complex partial (CPS) or secondary generalized tonic-clonic seizure (GTCS) during video-EEG monitoring in 25 patients suffering from temporal epilepsy. IL-6 increased by 51% immediately after the seizure (p<0.01) and remained elevated for 24h. This increase lacked in patients with hippocampal sclerosis (HS; n=16, mean increase 28%, p>0.5, vs. 112%, p<0.01 in patients without HS). IL-6 levels were higher after right-sided seizures as compared to left-sided seizures 24h after the seizure (8.7pg/mL vs. 3.4pg/mL, p<0.05). In patients taking valproate (VPA, n=9), the levels of IL-1beta were higher as compared to patients not treated with VPA. The results suggest a relationship between the cytokine system and characteristics of TLE such as side and pathology.
authors.affiliation: Department of Neurology, University of Marburg, Marburg, Germany. bauerse@med.uni-marburg.de
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bauer
authors.forename: Sabine
authors.initials: S
authors.lastname: Cepok
authors.forename: Anelia
authors.initials: A
authors.lastname: Todorova-Rudolph
authors.forename: Mareike
authors.initials: M
authors.lastname: Nowak
authors.forename: Martina
authors.initials: M
authors.lastname: Köller
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Lorenz
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Oertel
authors.forename: Felix
authors.initials: F
authors.lastname: Rosenow
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hemmer
authors.forename: Hajo M
authors.initials: HM
authors.lastname: Hamer
mesh_terms: D000293:Adolescent; D000328:Adult; D016207:Cytokines / Q000097:blood*; D004569:Electroencephalography; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000097:blood / Q000209:etiology / Q000473:pathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014741:Video Recording; D055815:Young Adult
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha