title: [Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons].
abstract: Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devoted currently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.
authors.forename: H A
authors.initials: HA
authors.lastname: Savchenko
authors.forename: A A
authors.initials: AA
authors.lastname: Vasylevs'kyĭ
authors.forename: K A
authors.initials: KA
authors.lastname: Pluzhnykov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Korol'kova
authors.forename: M V
authors.initials: MV
authors.lastname: Mamenko
authors.forename: T M
authors.initials: TM
authors.lastname: Volkova
authors.forename: O P
authors.initials: OP
authors.lastname: Maksymiuk
authors.forename: Ia A
authors.initials: IaA
authors.lastname: Boĭchuk
authors.forename: Ie V
authors.initials: IeV
authors.lastname: Hrishyn
authors.forename: O O
authors.initials: OO
authors.lastname: Kryshtal'
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured; D018408:Patch-Clamp Techniques; D010446:Peptide Fragments / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D058469:Receptors, Purinergic P2X; D011984:Sensory Receptor Cells / Q000187:drug effects* / Q000378:metabolism; D013111:Spider Venoms / Q000737:chemistry*; D013112:Spiders
chemical_list: D010446:Peptide Fragments; D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; D013111:Spider Venoms