title: Cushing disease in a toddler: not all obese children are just fat.
abstract: Cushing disease is exceedingly rare in children, especially in those under the age of 2 years. This case report describes an 18-month-old female child who presented with morbid obesity, decreased linear growth, and reversal of developmental milestones. Her diagnosis was delayed; however, she was successfully treated by surgical excision of the microadenoma. This was followed by resolution of signs and symptoms of Cushing syndrome. Although the patient's hypertension resolved, linear growth improved and development began to progress, she is still developmentally delayed and now has hypopituitarism. Review of this case, as well as a handful of other cases of infantile Cushing disease in the literature, suggests that features such as hypertension and slowed linear growth, which are rare in nutritional causes of obesity in infants, can help identify this rare, but life-threatening, illness among an increasing number of overweight infants.
authors.affiliation: Division of Endocrinology, Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA. moriarty.megan@tchden.org
authors.forename: Megan
authors.initials: M
authors.lastname: Moriarty
authors.forename: Francis
authors.initials: F
authors.lastname: Hoe
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D003399:Craniotomy; D003480:Cushing Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D004210:Dissection; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D007223:Infant; D009767:Obesity, Morbid / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D010902:Pituitary Gland / Q000473:pathology / Q000601:surgery