Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism.
During and after prolonged bed rest, changes in bone metabolic markers occur within 3 days. Resistive vibration exercise during bed rest impedes bone loss and restricts increases in bone resorption markers whilst increasing bone formation.


BACKGROUND
To investigate the effectiveness of a resistive vibration exercise (RVE) countermeasure during prolonged bed rest using serum markers of bone metabolism and whole-body dual X-ray absorptiometry (DXA) as endpoints.


METHODS
Twenty healthy male subjects underwent 8 weeks of bed rest with 12 months follow-up. Ten subjects performed RVE. Blood drawings and DXA measures were conducted regularly during and after bed rest.


RESULTS
Bone resorption increased in the CTRL group with a less severe increase in the RVE group (p = 0.0004). Bone formation markers increased in the RVE group but decreased marginally in the CTRL group (p < 0.0001). At the end of bed rest, the CTRL group showed significant loss in leg bone mass (-1.8(0.9)%, p = 0.042) whereas the RVE group did not (-0.7(0.8)%, p = 0.405) although the difference between the groups was not significant (p = 0.12).


CONCLUSIONS
The results suggest the countermeasure restricts increases in bone resorption, increased bone formation, and reduced bone loss during bed rest.
Armbrecht
G
G
Zentrum für Muskel- und Knochenforschung, Charité Campus Benjamin Franklin, Berlin, Germany. gabi.armbrecht@charite.de
Belavý
D L
DL
Gast
U
U
Bongrazio
M
M
Touby
F
F
Beller
G
G
Roth
H J
HJ
Perschel
F H
FH
Rittweger
J
J
Felsenberg
D
D
D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D001510:Bed Rest / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001823:Body Composition; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000652:urine; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009133:Muscular Atrophy / Q000209:etiology / Q000517:prevention & control*; D055070:Resistance Training / Q000379:methods*; D014732:Vibration / Q000627:therapeutic use*
D015415:Biomarkers; D002118:Calcium