title: Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome treated with a combination of isotretinoin and pamidronate.
abstract: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a clinically heterogeneous entity, encompassing a variety of debilitating conditions that have in common inflammation of the skeletal system and skin. To date, there is a paucity of documented efficacious treatment options. We report a 48-year-old man with skeletal and cutaneous signs and symptoms who improved dramatically after treatment with a combination of isotretinoin and pamidronate. This report provides an alternative treatment regimen for SAPHO that addresses the possible underlying pathophysiology of this likely underdiagnosed syndrome.
authors.affiliation: Department of Dermatology, Boston University School of Medicine, Boston, MA, USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Galadari
authors.forename: Alyssa G
authors.initials: AG
authors.lastname: Bishop
authors.forename: Suraj S
authors.initials: SS
authors.lastname: Venna
authors.forename: Emad
authors.initials: E
authors.lastname: Sultan
authors.forename: Daihung
authors.initials: D
authors.lastname: Do
authors.forename: Ross
authors.initials: R
authors.lastname: Zeltser
mesh_terms: D017486:Acneiform Eruptions / Q000188:drug therapy*; D004164:Diphosphonates / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D015576:Hyperostosis / Q000188:drug therapy*; D015474:Isotretinoin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010000:Osteitis / Q000188:drug therapy*; D000077268:Pamidronate; D011565:Psoriasis / Q000188:drug therapy*; D012871:Skin Diseases / Q000188:drug therapy*; D013577:Syndrome; D013585:Synovitis / Q000188:drug therapy*
chemical_list: D004164:Diphosphonates; D015474:Isotretinoin; D000077268:Pamidronate