title: Solid corneal dermoids and subconjunctival lipodermoids: impact of differentiated surgical therapy on the functional long-term outcome.
abstract: OBJECTIVE
  The functional long-term outcome after differentiated surgical therapy of solid corneal dermoids and subconjunctival lipodermoids with special regard to determinants for amblyopia will be assessed.
  
  
  METHODS
  Forty-six consecutive patients undergoing surgery for solid epibulbar dermoids, subconjunctival lipodermoids, or both were included. Visual acuity, refraction, keratometry, and degree of amblyopia were determined. Surgical therapy for corneal dermoids consisted of lamellar sclerokeratectomy, lamellar keratoplasty, corneoscleroplasty, and lamellar removal with autologous episcleral transplant. Surgical therapy for lipodermoids consisted of excision and reduction of the volume of the tumor. Follow-up examination was performed on average 4.5 years after surgical intervention.
  
  
  RESULTS
  A significant correlation between tumor volume and preoperative visual acuity could be observed in patients with solid corneal dermoids not occluding the optical axis. Visual acuity improved significantly from 0.21 +/- 0.4 to 0.35 +/- 0.4 after surgery of corneal dermoids. Most eyes had concomitant hyperopia. Postoperative visual acuity correlated positively with preoperative visual acuity (P = 0.0001). After tumor excision, hyperopia and astigmatism were not reduced significantly on average. Nineteen of 47 patients suffered from amblyopia. Amblyopia was more often observed in patients with preoperative hyperopia > or =2 diopters and astigmatism >2 diopters. Visual acuity, refraction, and astigmatism were not changed significantly by surgery in patients with subconjunctival lipodermoids.
  
  
  CONCLUSIONS
  Epibulbar dermoids require differentiated surgical therapy. Amblyopia is a major threat of solid corneal dermoids. The incidence of amblyopia seems to depend on preoperative occlusion of the optical axis and preoperative degree of hyperopia and astigmatism.
authors.affiliation: Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: Petros
authors.initials: P
authors.lastname: Stergiopoulos
authors.forename: Barbara
authors.initials: B
authors.lastname: Link
authors.forename: Gottfried O H
authors.initials: GO
authors.lastname: Naumann
authors.forename: Berthold
authors.initials: B
authors.lastname: Seitz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000550:Amblyopia / Q000209:etiology / Q000517:prevention & control; D001251:Astigmatism / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003230:Conjunctival Neoplasms / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D003316:Corneal Diseases / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D003884:Dermoid Cyst / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D005134:Eye Neoplasms / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D006956:Hyperopia / Q000209:etiology; D007223:Infant; D008067:Lipoma / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D011184:Postoperative Period; D011300:Preoperative Care; D013997:Time Factors; D016896:Treatment Outcome; D014792:Visual Acuity; D055815:Young Adult