title: Autologous platelets and leukocytes can improve healing of infected high-energy soft tissue injury.
abstract: Despite advances in surgical techniques and pharmacology, healing of injury-associated soft tissue defects is frequently complicated by infections, which often requires a secondary intervention. Cytokines are important mediators of healing. Application of autologous platelet-rich plasma enriched in growth factors and antimicrobial proteins, known also as platelet-leukocyte rich plasma (PLRP), represents a novel approach to the treatment of soft tissue and bone healing disturbances. This case is the first report on the application of PLRP in an infected high-energy soft tissue injury and shows that the volume and concentration of platelets and leukocytes is adequate to induce healing processes despite concurrent infection.
authors.affiliation: Department and Clinic of Orthopedics, Medical University of Silesia, Pl. Medyków 1, 41-200 Sosnowiec, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Cieslik-Bielecka
authors.forename: Tomasz
authors.initials: T
authors.lastname: Bielecki
authors.forename: Tadeusz S
authors.initials: TS
authors.lastname: Gazdzik
authors.forename: Jerzy
authors.initials: J
authors.lastname: Arendt
authors.forename: Wojciech
authors.initials: W
authors.lastname: Król
authors.forename: Tomasz
authors.initials: T
authors.lastname: Szczepanski
mesh_terms: D000062:Accidents, Occupational; D000328:Adult; D001775:Blood Circulation; D001804:Blood Transfusion, Autologous / Q000379:methods*; D006801:Humans; D017708:Leukocyte Transfusion / Q000379:methods*; D008297:Male; D018919:Neovascularization, Physiologic; D017713:Platelet Transfusion / Q000379:methods*; D011150:Popliteal Artery / Q000293:injuries; D011152:Popliteal Vein / Q000293:injuries; D012449:Safety; D017695:Soft Tissue Injuries / Q000601:surgery*; D014945:Wound Healing