Pregnancy, postpartum autoimmune thyroiditis, and autoimmune hypophysitis: intimate relationships.
Autoimmune diseases comprise a group of about 85 heterogeneous conditions that can affect virtually any organ and tissue in the body. Many autoimmune diseases change significantly during pregnancy: some ameliorate, some worsen, and others are unaffected. Two autoimmune diseases present prominently in relation to pregnancy: postpartum autoimmune thyroiditis and autoimmune hypophysitis. This article will review the current state of knowledge of the immunological changes that occur during normal pregnancy, and will explore the striking temporal association with pregnancy observed in thyroiditis and hypophysitis.
Landek-Salgado
Melissa A
MA
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
Gutenberg
Angelika
A
Lupi
Isabella
I
Kimura
Hiroaki
H
Mariotti
Stefano
S
Rose
Noel R
NR
Caturegli
Patrizio
P
D000818:Animals; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D010900:Pituitary Diseases / Q000150:complications / Q000276:immunology*; D050032:Postpartum Thyroiditis / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*