title: Treatment of Poikiloderma of Civatte with ablative fractional laser resurfacing: prospective study and review of the literature.
abstract: BACKGROUND
  Previous laser treatments for Poikiloderma of Civatte (PC) (i.e., Pulsed dye, Intense Pulsed Light, KTP and Argon) are limited by side effect profiles and/or efficacy. Given the high degree of safety and efficacy of ablative fractional photothermolysis (AFP) for photoaging, we set out to assess the efficacy of PC with AFP.
  
  
  METHODS
  A prospective pilot study for PC in 10 subjects with a series of 1-3 treatment sessions. Treatment sessions were administered at 6-8 week intervals with blinded physician photographic analysis of improvement at 2 months post-treatment. Evaluation was performed of five clinical indicators, erythema/telangiecatasia, dyschromia, skin texture, skin laxity and cosmetic outcome.
  
  
  RESULTS
  The number of treatments required for improvement of PC ranged from 1 to 3, with an average of 1.4. For erythema/telangiecatasia, the mean score improved 65.0% (95% CI: 60.7%, 69.3%) dyschromia, 66.7% (95% CI: 61.8%, 71.6%), skin texture, 51.7% (95% CI: 48.3%, 55.1%) and skin laxity, 52.5% (95% CI: 49.6%, 55.4%). For cosmetic outcome, the mean score improved 66.7% (95% CI: 62.6%, 70.8%) at 2 months post treatment.
  
  
  CONCLUSIONS
  In this prospective study, AFP was both safe and effective for the treatment of the vascular, pigmentary and textural components of PC. The degree of improvement observed in wrinkling, creping and laxity after AFP has not been reported with prior laser treatments for PC.
authors.affiliation: Laser and Skin Surgery Center of Indiana, Carmel, IN, USA.
authors.forename: Emily P
authors.initials: EP
authors.lastname: Tierney
authors.forename: C William
authors.initials: CW
authors.lastname: Hanke
mesh_terms: D000368:Aged; D002245:Carbon Dioxide; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053685:Laser Therapy; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012871:Skin Diseases / Q000601:surgery*; D013684:Telangiectasis / Q000601:surgery*
chemical_list: D002245:Carbon Dioxide