Turnover of organelles by autophagy in yeast.
Efficient detection and removal of superfluous or damaged organelles are crucial to maintain cellular homeostasis and to assure cell survival. Growing evidence shows that organelles or parts of them can be removed by selective subtypes of otherwise unselective macroautophagy and microautophagy. This requires both the adaptation of the core autophagic machinery and sophisticated mechanisms to recognize organelles destined for turnover. We review the current knowledge on autophagic removal of peroxisomes, mitochondria, ER and parts of the nucleus with an emphasis on yeasts as a model eukaryote.
Farré
Jean-Claude
JC
Division of Biological Sciences, University of California, San Diego, CA 92093-0322, USA.
Krick
Roswitha
R
Subramani
Suresh
S
Thumm
Michael
M
D001343:Autophagy; D000071183:Autophagy-Related Proteins; D002467:Cell Nucleus / Q000378:metabolism; D005658:Fungi / Q000378:metabolism*; D006706:Homeostasis; D008055:Lipids / Q000737:chemistry; D008565:Membrane Proteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D015388:Organelles / Q000378:metabolism*; D010588:Phagosomes / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
C434065:ATG9 protein, S cerevisiae; D000071183:Autophagy-Related Proteins; D008055:Lipids; D008565:Membrane Proteins; D018129:Phosphatidylinositol Phosphates; D029701:Saccharomyces cerevisiae Proteins; C055525:phosphatidylinositol 3-phosphate; D011494:Protein Kinases; C477823:ATG1 protein, S cerevisiae