Health-related quality of life following surgical menopause and following gonadotrophin-releasing hormone analogue-induced pseudomenopause.
OBJECTIVE
To compare the health-related quality of life (HRQOL) following surgical menopause with that following gonadotrophin-releasing hormone analogue (GnRHa)-induced pseudomenopause.


METHODS
Thirty-one women who received 3.75 mg of triptorelin injection subcutaneously every 4 weeks for 12 weeks after conservative surgery for severe endometriosis were reviewed (Group A). Thirty women who had surgical menopause for non-malignant conditions were reviewed after 12 weeks (Group B). Menopause-rating scale (MRS II) was used to assess the HRQOL.


RESULTS
Surgical menopause caused significant deterioration of HRQOL after 12 weeks, as compared to that caused by the pseudomenopause induced by the GnRHa injection (total MRS score: Group A, 16.60; Group B, 20.41; p = 0.04). Among the three subscales, there were no differences in the scores of somato-vegetative symptoms (Group A, 6.63; Group B, 6.90; p = 0.72) and urogenital symptoms (Group A, 3.50; Group B, 4.80; p = 0.06). Psychological symptoms showed significant difference (Group A, 6.46; Group B, 8.70; p = 0.01).


CONCLUSIONS
Surgical menopause causes significant deterioration of HRQOL than that caused by the pseudomenopause state of GnRHa injection. Psychological symptoms are more pronounced in surgical menopause.
Bhattacharya
Sudhindra Mohan
SM
Department of Obstetrics and Gynecology, S. C. Das Memorial Medical and Research Center, Kolkata, India. drsudhindra54@gmail.com
D000328:Adult; D004715:Endometriosis / Q000523:psychology / Q000601:surgery; D005260:Female; D006304:Health Status; D006801:Humans; D008186:Luteolytic Agents / Q000627:therapeutic use; D008594:Menopause, Premature / Q000523:psychology*; D018579:Patient Selection; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D008186:Luteolytic Agents; D017329:Triptorelin Pamoate