title: Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study.
abstract: OBJECTIVE
  Bone marrow stem cells (BMSC) were transplanted into the perilesional area in five patients bearing sequels of stroke, to evaluate the safety of the procedure and tolerance to the transplanted cells.
  
  
  METHODS
  Cells were obtained from bone marrow samples taken from the same patient and stereotactically implanted into the targets, determined using a combination of images, and trans-operative recording of multiunit activity. The cells were implanted in several points along tracts in the perilesional region.
  
  
  RESULTS
  No important adverse events derived from surgery or transplant were observed during the one year follow-up period, or detected using a combination of tests and functional measurements applied pre- and post-surgically. In contrast, some improvements were observed regarding the neurological condition of the patients, but the small number of patients in the study does not allow any conclusive statement.
  
  
  CONCLUSIONS
  Our results demonstrate that BMSC can be safely transplanted into the brain of patients, with excellent tolerance and without complications, using the methods described here.
authors.affiliation: Centro Internacional de Restauración Neurológica, Habana, Cuba.
authors.forename: Carlos
authors.initials: C
authors.lastname: Suárez-Monteagudo
authors.forename: Porfirio
authors.initials: P
authors.lastname: Hernández-Ramírez
authors.forename: Lázaro
authors.initials: L
authors.lastname: Alvarez-González
authors.forename: Iván
authors.initials: I
authors.lastname: García-Maeso
authors.forename: Karelys
authors.initials: K
authors.lastname: de la Cuétara-Bernal
authors.forename: Lázara
authors.initials: L
authors.lastname: Castillo-Díaz
authors.forename: María L
authors.initials: ML
authors.lastname: Bringas-Vega
authors.forename: Gilda
authors.initials: G
authors.lastname: Martínez-Aching
authors.forename: Lilia M
authors.initials: LM
authors.lastname: Morales-Chacón
authors.forename: Margarita M
authors.initials: MM
authors.lastname: Báez-Martín
authors.forename: Carlos
authors.initials: C
authors.lastname: Sánchez-Catasús
authors.forename: Maylen
authors.initials: M
authors.lastname: Carballo-Barreda
authors.forename: Rafael
authors.initials: R
authors.lastname: Rodríguez-Rojas
authors.forename: Lázaro
authors.initials: L
authors.lastname: Gómez-Fernández
authors.forename: Esteban
authors.initials: E
authors.lastname: Alberti-Amador
authors.forename: Consuelo
authors.initials: C
authors.lastname: Macías-Abraham
authors.forename: Elvira Dorticós
authors.initials: ED
authors.lastname: Balea
authors.forename: Lázaro Cortina
authors.initials: LC
authors.lastname: Rosales
authors.forename: Lázaro
authors.initials: L
authors.lastname: Del Valle Pérez
authors.forename: Berta B Socarrás
authors.initials: BB
authors.lastname: Ferrer
authors.forename: Raúl Macías
authors.initials: RM
authors.lastname: González
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Bergado
mesh_terms: D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000379:methods; D009483:Neuropsychological Tests; D020521:Stroke / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014182:Transplantation, Autologous / Q000379:methods