Structural changes in the liver and content of steroid hormones in the blood and adrenal glands of mice with systemic candidiasis treated with a composition of amphotericin B and dialdehyde dextran.
In CBA mice infected with C. albicans, phasic pattern of granulomatosis development was observed. In all groups, the number of granulomas in the liver was minimum on day 56 after infection. Treatment with free amphotericin B and its composition with dialdehyde dextran (CA) reduced the number of infiltrations and granulomas in the liver, the changes were more pronounced in animals receiving CA. A different pattern of cyclic fluctuations of cortisol content in the blood and adrenal glands and progesterone content in the adrenal gland was observed. By the end of observation (day 84), cortisol content in the blood and adrenals of mice treated with CA was considerably lower than in untreated mice and animals receiving amphotericin B.
Shkurupiy
V A
VA
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. sck@soramn.ru
Selyatitskaya
V G
VG
Palchikova
N A
NA
Kurilin
V V
VV
Tsyrendorzhiev
D D
DD
Travin
M A
MA
Nadeev
A P
AP
D000305:Adrenal Cortex Hormones / Q000097:blood* / Q000378:metabolism; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D003911:Dextrans / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006099:Granuloma / Q000473:pathology; D006854:Hydrocortisone / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011374:Progesterone / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D000925:Anticoagulants; D000935:Antifungal Agents; D003911:Dextrans; C026948:dextran dialdehyde; D011374:Progesterone; D000666:Amphotericin B; D006854:Hydrocortisone