title: Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease.
abstract: In the present voxel-based morphometric study, we investigated whether the severity and duration of disease are associated with alterations in gray matter volume (GMV) in symptomatic Parkin mutation carriers (sPARKIN-MC) and patients with idiopathic Parkinson's disease (iPD). Regression analyses revealed different negative correlations between GMV in cortical motor areas and the severity as well as the disease duration in sPARKIN-MC and iPD patients. SPARKIN-MC showed a less involvement of cortical motor areas, in particular in the supplementary motor area (SMA) than iPD patients. Specifically, in iPD patients, but not in sPARKIN-MC, there was a negative correlation between the SMA degeneration and the UPDRS-II item freezing. The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies.
authors.affiliation: Department of Neurology, University of Luebeck, 23538 Luebeck, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Reetz
authors.forename: H R
authors.initials: HR
authors.lastname: Siebner
authors.forename: C
authors.initials: C
authors.lastname: Gaser
authors.forename: J
authors.initials: J
authors.lastname: Hagenah
authors.forename: C
authors.initials: C
authors.lastname: Buechel
authors.forename: M
authors.initials: M
authors.lastname: Kasten
authors.forename: D
authors.initials: D
authors.lastname: Petersen
authors.forename: P P
authors.initials: PP
authors.lastname: Pramstaller
authors.forename: C
authors.initials: C
authors.lastname: Klein
authors.forename: F
authors.initials: F
authors.lastname: Binkofksi