title: Subgenual cingulate and visual cortex responses to sad faces predict clinical outcome during antidepressant treatment for depression.
abstract: BACKGROUND
  Previous follow-up studies indicate that increased visual cortical, ventral cingulate and subcortical responses of depressed individuals to sad facial stimuli, but not happy stimuli could represent reversible markers of disease severity. We hypothesized that greater responses in these areas to sad stimuli, but not happy stimuli, would predict better subsequent clinical outcome. We also explored areas that would predict a poor outcome.
  
  
  METHODS
  Twelve melancholically depressed individuals in the early stages of antidepressant treatment in a secondary care setting participated in two experiments comparing responses to varying intensities of sad and happy facial stimuli, respectively, using event related functional MRI. They repeated the experiments after a mean delay of 12 weeks of treatment.
  
  
  RESULTS
  There was a variation in response to treatment. Greater right visual cortex and right subgenual cingulate (R-BA25) responses to sad stimuli, but not happy stimuli, in the early stages of treatment were associated with a good clinical outcome. Greater ventrolateral prefrontal cortex responses to either stimulus type were associated with a relatively poor outcome.
  
  
  CONCLUSIONS
  The sample size was modest and patients were taking a variety of antidepressants.
  
  
  CONCLUSIONS
  Right subgenual cingulate and right visual cortical responses to sad stimuli predict good clinical outcome in the context of antidepressant treatment for severe depression in a naturalistic setting. Ventrolateral prefrontal cortex activity may indicate poor prognosis due to its relationship with negative rumination.
authors.affiliation: Department of Psychological Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. keedwellpa@cf.ac.uk
authors.forename: Paul A
authors.initials: PA
authors.lastname: Keedwell
authors.forename: Dominique
authors.initials: D
authors.lastname: Drapier
authors.forename: Simon
authors.initials: S
authors.lastname: Surguladze
authors.forename: Vincent
authors.initials: V
authors.lastname: Giampietro
authors.forename: Mick
authors.initials: M
authors.lastname: Brammer
authors.forename: Mary
authors.initials: M
authors.lastname: Phillips
mesh_terms: D000339:Affect; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005149:Facial Expression; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017397:Prefrontal Cortex / Q000502:physiology; D011379:Prognosis; D012720:Severity of Illness Index; D014793:Visual Cortex / Q000502:physiology*
chemical_list: D000928:Antidepressive Agents