Merkel cell polyomavirus strains in patients with merkel cell carcinoma.
We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.
Touzé
Antoine
A
Institut National de la Santé et de la Recherche Médicale, Unit 618, Tours, France.
Gaitan
Julien
J
Maruani
Annabel
A
Le Bidre
Emmanuelle
E
Doussinaud
Angélique
A
Clavel
Christine
C
Durlach
Anne
A
Aubin
François
F
Guyétant
Serge
S
Lorette
Gérard
G
Coursaget
Pierre
P
D000368:Aged; D000369:Aged, 80 and over; D036022:Capsid Proteins / Q000235:genetics; D015266:Carcinoma, Merkel Cell / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D018862:Merkel Cells / Q000821:virology*; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D011120:Polyomavirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D027601:Polyomavirus Infections / Q000821:virology*; D017422:Sequence Analysis, DNA; D012878:Skin Neoplasms / Q000821:virology*; D014412:Tumor Virus Infections / Q000821:virology*
D036022:Capsid Proteins; D004279:DNA, Viral; C062481:VP1 protein, polyomavirus