title: Cellular systems biology profiling applied to cellular models of disease.
abstract: Building cellular models of disease based on the approach of Cellular Systems Biology (CSB) has the potential to improve the process of creating drugs as part of the continuum from early drug discovery through drug development and clinical trials and diagnostics. This paper focuses on the application of CSB to early drug discovery. We discuss the integration of protein-protein interaction biosensors with other multiplexed, functional biomarkers as an example in using CSB to optimize the identification of quality lead series compounds.
authors.affiliation: Cellumen, Inc., 3180 William Pitt Way, Pittsburgh, PA 15238, USA. kgiuliano@cellumen.com
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Giuliano
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Premkumar
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Strock
authors.forename: Patricia
authors.initials: P
authors.lastname: Johnston
authors.forename: Lansing
authors.initials: L
authors.lastname: Taylor
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D055808:Drug Discovery; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D051736:Proto-Oncogene Proteins c-mdm2 / Q000737:chemistry / Q000378:metabolism; D049490:Systems Biology / Q000379:methods*; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2