title: Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye.
abstract: We demonstrate the first evidence of radioactivity-synchronized fluorescence quenching of a near-infrared light-emitting dye by a radionuclide, (64)Cu, and subsequent fluorescence enhancement upon (64)Cu decay to the daughter isotopes (64)Ni and (64)Zn. The dynamic switch from high radioactivity and low fluorescence to low radioactivity and high fluorescence is potentially useful for developing complementary multimodal imaging and detection platforms for chemical, environmental, and biomedical applications as well as for unraveling the mechanisms of metal-induced dynamic fluorescence changes.
authors.affiliation: Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, Missouri 63110, USA.
authors.forename: Mikhail Y
authors.initials: MY
authors.lastname: Berezin
authors.forename: Kevin
authors.initials: K
authors.lastname: Guo
authors.forename: Bao
authors.initials: B
authors.lastname: Teng
authors.forename: W Barry
authors.initials: WB
authors.lastname: Edwards
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Anderson
authors.forename: Olga
authors.initials: O
authors.lastname: Vasalatiy
authors.forename: Amir
authors.initials: A
authors.lastname: Gandjbakhche
authors.forename: Gary L
authors.initials: GL
authors.lastname: Griffiths
authors.forename: Samuel
authors.initials: S
authors.lastname: Achilefu
mesh_terms: D002614:Chelating Agents / Q000737:chemistry; D003301:Copper Radioisotopes / Q000737:chemistry*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D011851:Radioactivity; D011868:Radioisotopes / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D017186:Titrimetry; D015037:Zinc Radioisotopes / Q000737:chemistry
chemical_list: D002614:Chelating Agents; D003301:Copper Radioisotopes; D005456:Fluorescent Dyes; D011868:Radioisotopes; D015037:Zinc Radioisotopes; D009532:Nickel