Regulation of mRNA translation in renal physiology and disease.
Translation, a process of generating a peptide from the codons present in messenger RNA, can be a site of independent regulation of protein synthesis; it has not been well studied in the kidney. Translation occurs in three stages (initiation, elongation, and termination), each with its own set of regulatory factors. Mechanisms controlling translation include small inhibitory RNAs such as microRNAs, binding proteins, and signaling reactions. Role of translation in renal injury in diabetes, endoplasmic reticulum stress, acute kidney injury, and, in physiological adaptation to loss of nephrons is reviewed here. Contribution of mRNA translation to physiology and disease is not well understood. Because it is involved in such diverse areas as development and cancer, it should prove a fertile field for investigation in renal science.
Kasinath
Balakuntalam S
BS
Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. kasinath@uthscsa.edu
Feliers
Denis
D
Sataranatarajan
Kavithalakshmi
K
Ghosh Choudhury
Goutam
G
Lee
Myung Ja
MJ
Mariappan
Meenalakshmi M
MM
D000818:Animals; D003928:Diabetic Nephropathies / Q000378:metabolism / Q000503:physiopathology; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D007674:Kidney Diseases / Q000378:metabolism / Q000503:physiopathology*; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis*; D015398:Signal Transduction
D012333:RNA, Messenger