Structure, expression, and regulation of UDP-GlcNAc: dolichol phosphate GlcNAc-1-phosphate transferase (DPAGT1).
Glycosylation of proteins on asparagine amino acids (N-linked) in proteins of eukaryotic cells is initiated by the biosynthesis of dolichol-pyrophosphate-N-acetylglucosamine from dolichol-phosphate and UDP-N-acetylglucosamine. The enzyme catalyzing this reaction, UDP-GlcNAc:Dolichol Phosphate GlcNAc-1-Phosphate Transferase (DPAGT1), has been further characterized in several cell types with respect to its gene, gene products, membrane topology, functional sites, lipid dependence, and metabolic regulation. This review summarizes these properties as an update from an earlier detailed and critical review by Lehrman (Lehrman, M. A. (1991) Glycobiology, 1, 553-562).
Bretthauer
Roger K
RK
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. Roger.K.Bretthauer.1@nd.edu
D000818:Animals; D002384:Catalysis; D005057:Eukaryotic Cells / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D006031:Glycosylation; D006801:Humans; D055503:Protein Multimerization; D017855:Transferases (Other Substituted Phosphate Groups) / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000502:physiology*
D017855:Transferases (Other Substituted Phosphate Groups); C023222:UDPacetylglucosamine-dolichyl-phosphate acetylglucosamine-1-phosphate transferase