Cognitive impairment in the septic brain.
Sepsis is a major disease entity with important clinical implications. It is associated with a high mortality rate in humans. Recently, several studies have demonstrated that Intensive Care Unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration and/or global loss of cognitive function. The pathogenesis of septic encephalopathy and cognitive impairment are still poorly known and further understanding of these processes is necessary for the development of effective preventive and therapeutic interventions. Here we discuss the clinical presentation and underlying pathophysiology of the encephalopathy and neurobiology of the cognitive impairment associated with sepsis.
Comim
Clarissa M
CM
Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, SC, Brazil
Constantino
Leandra C
LC
Barichello
Tatiana
T
Streck
Emílio L
EL
Quevedo
João
J
Dal-Pizzol
Felipe
F
D000818:Animals; D001927:Brain Diseases / Q000188:drug therapy / Q000209:etiology*; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D008954:Models, Biological; D009446:Neurobiology; D018805:Sepsis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology