title: Anti-angiogenesis and anti-tumor effects of AdNT4-anginex.
abstract: Anginex is a novel artificial peptide that can inhibit angiogenesis. AdNT4-anginex was constructed by inserting the artificial anginex gene into a recombinant adenoviral vector. We demonstrated that AdNT4-anginex inhibited migration of human endothelial cells, angiogenesis and tumor growth in in vitro and in vivo studies. Tumor growth of human H22 hepatoma in mice was inhibited after AdNT4-anginex treatment for 4 weeks, and a significant decrease in tumor size was observed as compared with the control group. Overall, these studies indicate that AdNT4-anginex is an effective anti-tumor agent, and deserves more attention and research.
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Dan Feng
authors.initials: DF
authors.lastname: Dong
authors.forename: En Xiao
authors.initials: EX
authors.lastname: Li
authors.forename: Ju Bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Yin Ying
authors.initials: YY
authors.lastname: Wu
authors.forename: Fan
authors.initials: F
authors.lastname: Shi
authors.forename: Jun Jun
authors.initials: JJ
authors.lastname: Guo
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wu
authors.forename: Jun Ping
authors.initials: JP
authors.lastname: Liu
authors.forename: Shan Xi
authors.initials: SX
authors.lastname: Liu
authors.forename: Guang Xiao
authors.initials: GX
authors.lastname: Yang
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002642:Chick Embryo; D005260:Female; D005822:Genetic Vectors; D006801:Humans; D051379:Mice; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D010455:Peptides; D011506:Proteins / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; D011506:Proteins; C111993:betapep-25 protein, synthetic