title: Refractory recurrent thymoma successfully treated with long-acting somatostatin analogue and prednisolone.
abstract: The patient was 54-year-old woman diagnosed as recurrent invasive thymoma (type B3; WHO classification). Although partial response was obtained by systemic chemotherapy (PAC: cisplatin, doxorubicin, cyclophosphamide), the tumor started to become enlarged after cessation of chemotherapy. Combined treatment of octreotide and prednisolone was administrated because various chemotherapies, including PAC, were not effective. After seven months, the tumor size was markedly decreased. The combination of octreotide and prednisolone should be considered as one of the choices of treatment in patients with recurrent thymoma.
authors.affiliation: Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo.
authors.forename: Jun
authors.initials: J
authors.lastname: Ito
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Sekiya
authors.forename: Kayo
authors.initials: K
authors.lastname: Miura
authors.forename: Kaku
authors.initials: K
authors.lastname: Yoshimi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Seyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Izumi
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Uekusa
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D015282:Octreotide / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D013004:Somatostatin / Q000031:analogs & derivatives*; D013945:Thymoma / Q000188:drug therapy*; D013953:Thymus Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013004:Somatostatin; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D002945:Cisplatin; D015282:Octreotide