title: Efficacy of TachoSil a fibrin-based haemostat in different fields of surgery--a systematic review.
abstract: BACKGROUND
  Proper haemostasis is an important prerequisite for a successful outcome in all operative fields. TachoSil is used in many surgical specialties, especially for diffuse bleeding. However, TachoSil is not only used for haemostasis but also for closure of other anatomical structures.
  
  
  OBJECTIVE
  To review the literature concerning the efficacy of TachoSil, a topical fibrin-based haemostat.
  
  
  METHODS
  PubMed was searched for data on TachoSil and TachoComb from clinical trials and basic research.
  
  
  CONCLUSIONS
  TachoSil is used in many surgical specialties and has proven to be a valuable tool for several indications. It also seems to be cost effective. Solid data from randomized controlled trials are available for liver surgery, thoracic surgery and urology where a positive value is clearly documented.
authors.affiliation: University Hospital Zurich, Department of Visceral and Transplantation Surgery, Zurich, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Rickenbacher
authors.forename: Stefan
authors.initials: S
authors.lastname: Breitenstein
authors.forename: Mickael
authors.initials: M
authors.lastname: Lesurtel
authors.forename: Andrea
authors.initials: A
authors.lastname: Frilling
mesh_terms: D000818:Animals; D004338:Drug Combinations; D005340:Fibrinogen / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006487:Hemostasis; D006801:Humans; D007431:Intraoperative Complications / Q000188:drug therapy; D013514:Surgical Procedures, Operative / Q000379:methods*; D013917:Thrombin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; C518955:TachoSil; D005340:Fibrinogen; D013917:Thrombin