Developmental maturation of chemosensitivity to hypoxia of peripheral arterial chemoreceptors--invited article.
Peripheral arterial chemoreceptors, particularly the carotid body chemoreceptors, are the primary sites for the detection of hypoxia and reflexly increase ventilatory drive and behavioral arousal during hypoxic or asphyxial events. Newborn infants are at risk for hypoxic and asphyxial events during sleep, yet, the strength of the chemoreceptor responses is low or absent at birth and then progressively increases with early postnatal development. This review summarizes the available data showing that even though the "oxygen sensor" in the glomus cells has not been unequivocally identified, it is clear that development affects many of the other properties of the chemoreceptor unit (glomus cell, afferent nerve fibers and neurotransmitter profile at the synapse) that are necessary and essential for the propagation of the "sensing" response, and exposure to hypoxia, hyperoxia and nicotine can modify normal development of each of the components leading to altered peripheral chemoreceptor responses.
Gauda
Estelle B
EB
Department of Pediatrics, Division of Neonatology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. egauda@mail.jhmi.edu
Carroll
John L
JL
Donnelly
David F
DF
D000818:Animals; D001158:Arteries / Q000378:metabolism* / Q000473:pathology; D002344:Carotid Body / Q000378:metabolism; D002628:Chemoreceptor Cells / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism
D018377:Neurotransmitter Agents