Quantification of absolute myocardial blood flow by magnetic resonance perfusion imaging.
By serially imaging the myocardium during the initial transit of gadolinium contrast, magnetic resonance perfusion imaging can accurately assess relative reductions in regional myocardial blood flow and identify hemodynamically significant coronary artery disease. Models can be used to quantify myocardial blood flow (in milliliters/minute/gram) on the basis of dynamic signal changes within the myocardium and left ventricular cavity. Although the mathematical modeling involved in this type of analysis adds complexity, the benefits of absolute blood flow quantification might improve clinical diagnosis and have important implications for cardiovascular research.
Lee
Daniel C
DC
Feinberg Cardiovascular Research Institute, Department of Medicine and Division of Cardiology, Bluhm Cardiovascular Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. dlee@northwestern.edu
Johnson
Nils P
NP
D000818:Animals; D003287:Contrast Media; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology*; D003326:Coronary Circulation; D005682:Gadolinium; D006801:Humans; D018810:Magnetic Resonance Angiography; D008955:Models, Cardiovascular
D003287:Contrast Media; D005682:Gadolinium