Current considerations for the effective safety evaluation of drugs in vitro.
As the traditional in vivo tests are gradually shifting into in vitro tests, some new issues become apparent. This review discusses the essential considerations in endpoint selection, cell model quality, exposure concentration and linking factors between in vitro and in vivo studies in using in vitro models in risk assessment.
Xu
Jinsheng
J
Centre for Research in Biomedicine, Faculty of Health and Life Sciences, University of the West of England, Bristol, UK. jinsheng.xu@uwe.ac.uk
Jackson
Simon K
SK
D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods* / Q000592:standards; D064420:Drug-Related Side Effects and Adverse Reactions; D023381:Endpoint Determination; D006801:Humans; D011786:Quality Control; D012015:Reference Standards; D018570:Risk Assessment