Genetic predisposition to chikungunya--a blood group study in chikungunya affected families.
Chikungunya fever is a viral disease transmitted to humans by the bite of CHIKV virus infected Aedes mosquitoes. During monsoon outbreak of chikungunya fever, we carried out the genetic predisposition to chikungunya in disease affected 100 families by doing blood group (ABO) tests by focusing on individuals who were likely to have a risk of chikungunya and identified the blood group involved in susceptibility/resistance to chikungunya. In the present study, based on blood group antigens, the individuals were kept in four groups - A (108), B (98), AB (20) and O (243). The result obtained was showed all Rh positive blood group individuals are susceptible to chikungunya fever. Among ABO group, the blood group O +ve individuals are more susceptible to chikungunya than other blood groups. No blood group with Rh negative was affected with chikungunya, it indicates Rh -ve more resistance to chikungunya.
Lokireddy
Sudarsanareddy
S
Department of Biotechnology, Sri Krishnadevaraya University, Anantapur, India. l_suda2003@yahoo.co.in
Sarojamma
Vemula
V
Ramakrishna
Vadde
V
D000017:ABO Blood-Group System; D018354:Alphavirus Infections / Q000235:genetics*; D002646:Chikungunya virus / Q000472:pathogenicity*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System