title: Preoperative evaluation of patients with liver cirrhosis undergoing open heart surgery.
abstract: OBJECTIVE
  Clinical outcomes after open heart surgery in patients with liver cirrhosis are not satisfactory. For evaluating hepatic function, the Child-Pugh classification has been widely used. It has been reported that open heart surgery can be performed safely in patients with mild liver cirrhosis. In this study, we examined the clinical outcomes after open heart surgery in patients with liver cirrhosis and evaluated the usefulness of the Child-Pugh classification.
  
  
  METHODS
  There were 12 liver cirrhosis patients who underwent open heart surgery between January 2002 and December 2006 at our institution. The severity of cirrhosis was graded according to the Child-Pugh classification. We reviewed clinical outcomes, such as postoperative mortality and morbidity, and tried to determine the risk factors. Finally, we assessed the usefulness of the Child-Pugh classification.
  
  
  RESULTS
  Six patients were classified as having Child class A, and the other six patients were classified as B. The overall mortality of group A was 50%, and that of group B was 17%. Postoperative major morbidities occurred in half of the patients of Child class A and in all of the patients of Child class B. Patients who experienced major morbidities had markedly lower levels of serum cholinesterase (106 +/- 46 vs. 199 +/- 72 IU/l; P = 0.02) and lower platelet level (7.5 +/- 2.9 vs. 11.9 +/- 3.6 x 104/microl; P = 0.04).
  
  
  CONCLUSIONS
  The mortality and morbidity rates were high even in the Child class A patients. The Child classification may be an insufficient method for evaluating hepatic function. We have to assess other factors, such as the serum cholinesterase level or the platelet count.
authors.affiliation: Department of Cardiovascular Surgery, Kurashiki Central Hospital, Miwa, Kurashiki, Okayama, Japan. tm8937@kchnet.or.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Murashita
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Komiya
authors.forename: Nobushige
authors.initials: N
authors.lastname: Tamura
authors.forename: Genichi
authors.initials: G
authors.lastname: Sakaguchi
authors.forename: Taira
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Tomokuni
authors.initials: T
authors.lastname: Furukawa
authors.forename: Akihito
authors.initials: A
authors.lastname: Matsushita
authors.forename: Gengo
authors.initials: G
authors.lastname: Sunagawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000401:mortality; D002315:Cardiopulmonary Bypass; D002318:Cardiovascular Diseases / Q000150:complications / Q000601:surgery*; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011237:Predictive Value of Tests; D011300:Preoperative Care; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D002802:Cholinesterases