A linear, featured-data scheme for image reconstruction in time-domain fluorescence molecular tomography.
Fluorescence diffuse optical tomography (DOT) has attracted many attentions from the community of biomedical imaging, since it provides effective enhancement in imaging contrast. This modality is now rapidly evolving as a potential means of monitoring molecular events in small living organisms with help of molecule-specific contrast agents, referred to as fluorescence molecular tomography (FMT). FMT could greatly promote pathogenesis research, drug development, and therapeutic intervention. Although FMT in steady-state and frequency-domain modes have been heavily investigated, the extension to time-domain scheme is imminent for its several unique advantages over the others. By extending the previously developed generalized pulse spectrum technique for time-domain DOT, we propose a linear, featured-data image reconstruction algorithm for time-domain FMT that can simultaneously reconstruct both fluorescent yield and lifetime images of multiple fluorophores, and validate the methodology with simulated data.
Gao
Feng
F
College of Precision Instrument and Optoeletronics Engineering, Tianjin University, Tianjin 300072, China. gaofeng@tju.edu.cn
Zhao
Huijuan
H
Tanikawa
Yukari
Y
Yamada
Yukio
Y
D000465:Algorithms; D001499:Bayes Theorem; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D019047:Phantoms, Imaging; D013050:Spectrometry, Fluorescence / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*