title: The relationship between body composition and the urinary excretion of deoxypyridinoline and galactosyl-hydroxylysine in children and adolescents.
abstract: The study intends to investigate the relationship of body composition (%fat, percent body fat; FM, fat mass; FFM, fat free mass; FA and MA cross-sectional fat and muscle area) to the urinary excretion of deoxypyridinoline (DPD) and galactosyl-hydroxylysine (Gal-Hyl). 231 healthy children and adolescents (age 5-19 years; 112 males) of the DONALD study were analyzed for FM and FFM by measuring 4 skinfold thicknesses, for DPD and Gal-Hyl in urine samples and for bone parameters, FA and MA at the forearm by peripheral quantitative computed tomography. In contrast to adrenarchal females, adrenarchal males with low %fat had low levels of DPD and Gal-Hyl. %fat was correlated with DPD in pre-adrenarchal males (r = 0.290) and females (r = 0.298). Cortical bone mineral density (BMDcort) was correlated with DPD (r = -0.351) in adrenarchal males. Controlled for BMDcort, FM was correlated with DPD in pre-adrenarchal males (r = 0.348), and FA was correlated with DPD in pre-adrenarchal females (r = 0.294). FFM was negatively correlated with Gal-Hyl in adrenarchal males (r = -0.436) and females (r = -0.338). Less than 40% of variance of excreted DPD and Gal-Hyl was explained by regression models based on parameters of body composition. The effect of body composition explains the minor part of variance of the urinary excretion of DPD and Gal-Hyl. The association of body composition to excreted DPD and Gal-Hyl was not explained by the effect of adipose tissue on bone formation and bone resorption.
authors.affiliation: Children's Hospital, University of Cologne, 50924 Cologne, Germany. frickeo@uni-koeln.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Fricke
authors.forename: Christof
authors.initials: C
authors.lastname: Land
authors.forename: Ralf
authors.initials: R
authors.lastname: Beccard
authors.forename: Oliver
authors.initials: O
authors.lastname: Semler
authors.forename: Angelika
authors.initials: A
authors.lastname: Stabrey
authors.forename: Eckhard
authors.initials: E
authors.lastname: Schoenau
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000652:urine*; D000886:Anthropometry; D001823:Body Composition; D015519:Bone Density; D001862:Bone Resorption; D002648:Child; D005260:Female; D006801:Humans; D006901:Hydroxylysine / Q000031:analogs & derivatives* / Q000652:urine; D008297:Male; D012044:Regression Analysis
chemical_list: D000596:Amino Acids; C022819:hydroxylysine glycoside; D006901:Hydroxylysine; C036020:deoxypyridinoline