[Stability of inhalational anaesthestic agents].
Modern inhalational anaesthetics are liable to react with carbon dioxide absorbers and degrade under certain conditions. Sevoflurane may break down and produce toxic compounds in contact with Lewis acids or carbon dioxide absorbers. Desflurane, isoflurane and enflurane can also undergo undesirable reactions. Producers use various stabilizers, containers, and recommendations for storage times and conditions. In this paper, the possible dangers of inappropriate use of inhalational anaesthetics, and ways to avoid production of toxic compounds are presented. The composition and degradation of inhalational anaesthetics available on Polish market, are presented. The author concludes that safe use of these agents depends strongly on storage conditions and proper use by medical personnel.
Musioł
Robert
R
Instytut Chemii, Uniwersytet Slaski w Katowicach. robert.musiol@us.edu.pl
D018685:Anesthetics, Inhalation / Q000009:adverse effects / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003257:Consumer Product Safety; D004355:Drug Stability; D004356:Drug Storage; D005079:Excipients / Q000737:chemistry; D006801:Humans; D008956:Models, Chemical; D017410:Practice Guidelines as Topic; D018570:Risk Assessment
D018685:Anesthetics, Inhalation; D005079:Excipients