title: Multicomponent one-pot reactions: synthesis of some new 6-oxopyrano [2,3-c]isochromenes by condensation of homophthalic anhydride, dialkyl acetylenedicarboxylate, and isocyanides.
abstract: A novel three-component, one-pot condensation of the zwitterion generated from dialkyl acetylenedicarboxylate and isocyanides with homophthalic anhydride is described. The reaction affords new 6-oxopyrano[2,3-c]isochromenes in good yield. Isochromenes have been reported to possess diverse biological activities such as antibacterial, antifungal, antiinflammatory, and antiangiogenic effects. Moreover, Theses important compounds are found in various natural products.
authors.affiliation: Department of Chemistry, Shahid Beheshti University, Tehran, Iran. a-Mohammadi@cc.sbu.ac.ir
authors.forename: Ali A
authors.initials: AA
authors.lastname: Mohammadi
authors.forename: Roya
authors.initials: R
authors.lastname: Akbarzadeh
authors.forename: Hamed
authors.initials: H
authors.lastname: Rouhi
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003486:Cyanides / Q000138:chemical synthesis / Q000737:chemistry; D003998:Dicarboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000890:Anti-Infective Agents; D001578:Benzopyrans; D003486:Cyanides; D003998:Dicarboxylic Acids; C001354:homophthalic acid anhydride; D000114:Acetylene