title: Sacroiliitis and severe disability due to isotretinoin therapy.
abstract: We report a case of acute sacroiliitis with severe disability after only 3 weeks of isotretinoin therapy with graduate reduction of pain, limitation and muscle incompetence after discontinuation of the drug and ACTH-depo injection and Ethodolac therapy. Naranjo probability scale indicated a probable relationship between isotretinoin therapy and bilateral sacroiliitis. We discussed possible mechanisms of sacroiliitis and disability due to isotretinoin treatment.
authors.affiliation: B. Shine Department of Rheumatology, Rambam Health Care Campus and Technion, POB 9602, 31096, Haifa, Israel. a_rozin@rambam.health.gov.il
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Rozin
authors.forename: Olga
authors.initials: O
authors.lastname: Kagna
authors.forename: Yizhak
authors.initials: Y
authors.lastname: Shiller
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D018771:Arthralgia / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D001168:Arthritis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D003879:Dermatologic Agents / Q000009:adverse effects*; D004185:Disability Evaluation; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D017308:Etodolac / Q000627:therapeutic use; D006801:Humans; D007049:Iatrogenic Disease / Q000517:prevention & control; D015474:Isotretinoin / Q000009:adverse effects*; D017116:Low Back Pain / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology; D011859:Radiography; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome; D051598:Whole Body Imaging / Q000379:methods
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003879:Dermatologic Agents; D017308:Etodolac; D000324:Adrenocorticotropic Hormone; D015474:Isotretinoin