[Myocardial and renal morphological changes in drug addicts with infective endocarditis].
The autopsy specimens of the myocardium and kidneys from 233 patients with infective endocarditis (142 and 91 with and without a history of drug abuse, respectively) were studied by conventional microscopy and immunohistochemistry. In the drug abusers (DA), myocytolysis was a dominant form of myocardial damage and in the non-DA that was contraction degeneration. In DA, lower cardiomyocytic cl-2 expression arouses speculations on the possible role of apoptosis in the pathogenesis of heart failure in this group of patients. Membranous glomerulopathy was a hallmark of renal pathology in DA, contrasting with the predominance of mesangial lesions in non-DA. Increased CIC deposition may be regarded as a major contributing factor.
Rybakova
M G
MG
Kapitul'skaia
T B
TB
D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D001344:Autopsy; D004696:Endocarditis / Q000473:pathology*; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000473:pathology; D006333:Heart Failure / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000473:pathology*; D019966:Substance-Related Disorders / Q000473:pathology*