Liposome triggering of innate immune responses: a perspective on benefits and adverse reactions.
This commentary focuses on therapeutic advantages as well as adverse reactions that entail liposome triggering of the innate immune system, notably the complement cascade and macrophage clearance mechanisms. Our discussion is centered on macrophage drug delivery, evasion of macrophage surveillance, immunogenicity, and hypersensitivity.
Szebeni
Janos
J
Department of Nanomedicine, Institute of Nanotechnology, Bay Zoltán Foundation for Applied Research, Miskolc, Hungary.
Moghimi
Seyed Moein
SM
D000818:Animals; D003165:Complement System Proteins / Q000276:immunology; D016503:Drug Delivery Systems; D006801:Humans; D007107:Immune System / Q000276:immunology; D055633:Immune System Phenomena; D008081:Liposomes / Q000276:immunology*
D008081:Liposomes; D003165:Complement System Proteins