title: Antitrypanosomal activity of polycarpol from Piptostigma preussi (Annonaceae).
abstract: Polycarpol, sitosterol and sitosterol-3-O-beta-D-glucoside isolated for the first time from Piptostigma preussi (Annonaceae) occur regularly in some Annonaceae such as Piptostigma genus. Polycarpol exhibits interesting antitrypanosomal activity with an ED(50) value of 5.11 microM on Trypanosoma brucei cells. Moreover, it inhibits T. brucei glycolytic enzymes GAPDH and PFK with IC(50) values of 650 and 180 microM respectively.
authors.affiliation: Laboratory of Bio-organic and Medicinal Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Box 812 Yaounde, Cameroon. nwete@yahoo.fr
authors.forename: Igor
authors.initials: I
authors.lastname: Ngantchou
authors.forename: Ernestine
authors.initials: E
authors.lastname: Nkwengoua
authors.forename: Yves
authors.initials: Y
authors.lastname: Nganso
authors.forename: Barthelemy
authors.initials: B
authors.lastname: Nyasse
authors.forename: Colette
authors.initials: C
authors.lastname: Denier
authors.forename: Veronique
authors.initials: V
authors.lastname: Hannaert
authors.forename: Bernd
authors.initials: B
authors.lastname: Schneider
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems; D011084:Polycyclic Aromatic Hydrocarbons / Q000302:isolation & purification / Q000494:pharmacology*; D012855:Sitosterols / Q000302:isolation & purification; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects* / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D005960:Glucosides; D010936:Plant Extracts; D011084:Polycyclic Aromatic Hydrocarbons; D012855:Sitosterols; D014344:Trypanocidal Agents; C460801:polycarpol