Antifungal therapy for chronic rhinosinusitis: the controversy persists.
OBJECTIVE
Chronic rhinosinusitis is a debilitating disease seen frequently by allergist-immunologists. Recent research examining the pathophysiological mechanisms and treatment options for chronic rhinosinusitis have yielded contradicting results, particularly in regard to the role of fungi and antifungal therapies.


RESULTS
Recent studies using antifungal therapies for chronic rhinosinusitis will be critically evaluated with careful attention to sample selection, length of the intervention, drug delivery system, drug stability and handling, assessment of compliance to study medications, and choice of outcome measures with attention to study power (both primary and secondary). Using this framework to evaluate currently available studies reveals limitations in studies showing a benefit for antifungal therapy and in studies showing no benefit (or harm).


CONCLUSIONS
Limitations in studies that either support or refute the benefit of antifungal therapy for chronic rhinosinusitis prevent any firm conclusions about its efficacy.
Rank
Matthew A
MA
Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
Adolphson
Cheryl R
CR
Kita
Hirohito
H
D000935:Antifungal Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012220:Rhinitis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*; D016896:Treatment Outcome
D000935:Antifungal Agents