title: Discovery of functional miRNA-mRNA regulatory modules with computational methods.
abstract: The identification of miRNAs and their target mRNAs and the construction of their regulatory networks may give new insights into biological procedures. This study proposes a computational method to discover the functional miRNA-mRNA regulatory modules (FMRMs), that is, groups of miRNAs and their target mRNAs that are believed to participate cooperatively in post-transcriptional gene regulation under specific conditions. The proposed method identifies negatively regulated patterns of miRNAs and mRNAs which associate with cancer and normal conditions, respectively, in a prostate cancer data set. GO and the literature also suggest that they may relate with prostate cancer. It can potentially identify the biologically relevant chains of 'miRNA-->target gene --> condition'.
authors.affiliation: School of Computer and Information Science, University of South Australia, Mawson Lakes, SA 5095, Australia. Bing.Liu@unisa.edu.au
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Jiuyong
authors.initials: J
authors.lastname: Li
authors.forename: Anna
authors.initials: A
authors.lastname: Tsykin
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D019295:Computational Biology / Q000379:methods*; D053263:Gene Regulatory Networks / Q000502:physiology*; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods*; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D008957:Models, Genetic; D015233:Models, Statistical; D011471:Prostatic Neoplasms / Q000235:genetics; D012333:RNA, Messenger / Q000502:physiology*; D015203:Reproducibility of Results
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger