[Experimental investigation of combined action and hematotoxicity of anti-tumor antibiotic doxorubicin and industrial monomer acrylonitrile].
Industrial monomer acrylonitrile (AN) stimulated cancerogenesis in rats and humans. AN administration decreased an anti-tumor effect of anthracyclin antibiotic doxorubicin in rats with Pliss lymphosarcoma. A combined action of acrylonitrile and doxorubicin reduced erythrocytes and hemoglobin in rats without tumor and with Pliss lymphosarcoma more considerably than in rats with lymphosarcoma treated with doxorubicin. Hematotoxic effects of anthracyclin, doxorubicin and lymphosarcoma may be caused by stimulation of lipid peroxidation.
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D000181:Acrylonitrile / Q000633:toxicity*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002273:Carcinogens / Q000633:toxicity*; D004317:Doxorubicin / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism*; D008297:Male; D051381:Rats
D000903:Antibiotics, Antineoplastic; D002273:Carcinogens; D004317:Doxorubicin; D000181:Acrylonitrile