title: A randomized and blinded field trial to assess the efficacy of an autogenous vaccine to prevent naturally occurring infectious bovine keratoconjunctivis (IBK) in beef calves.
abstract: A randomized and blinded 2-arm parallel trial was conducted to assess the efficacy of an autogenous vaccine to prevent naturally occurring infectious bovine keratoconjunctivis (IBK) in beef calves. The trial was managed between May and November 2008 on university owned farms in Iowa and Wisconsin. The vaccine at Iowa contained Moraxella bovoculi (M. bovoculi) while the organism used in the Wisconsin herds vaccine was Branhemella ovis (B. ovis renamed M. ovis). Calves born between January and May 2008 without visible corneal lesions were randomized to receive an autogenous vaccine or placebo vaccine using a computer generated sequence. Two subcutaneous doses were administered 21-28 days apart. Allocation to treatment was concealed using bottles marked A or B. Staff were blind to the treatment allocation. The primary outcome was IBK cumulative incidence over the study period. The secondary outcome was weaning weight. Only the Iowa herd met the criteria for an "at-risk" herd i.e. >15% IBK in unvaccinated calves and M. bovoculi isolation from IBK cases. Analysis was "per-protocol". The cumulative incidence of IBK was 47/105 in vaccinated calves and 49/109 in unvaccinated calves (unadjusted odds ratio=0.99, 95% CI: 0.58-1.70). Weight at weaning did not differ between the vaccinated cohort 148kg (SD: +/-27) and unvaccinated cohort 146kg (SD: +/-26) (unadjusted beta=1.5 and 95% CI: -5.5 to 8.6). Results indicate that the autogenous vaccine was ineffective in this study population.
authors.affiliation: Department of Veterinary Diagnostics and Production Animal Medicine, Iowa State University College of Veterinary Medicine, Ames, IA 50011, USA. funk@iastate.edu
authors.forename: L
authors.initials: L
authors.lastname: Funk
authors.forename: A M
authors.initials: AM
authors.lastname: O'Connor
authors.forename: M
authors.initials: M
authors.lastname: Maroney
authors.forename: T
authors.initials: T
authors.lastname: Engelken
authors.forename: V L
authors.initials: VL
authors.lastname: Cooper
authors.forename: J
authors.initials: J
authors.lastname: Kinyon
authors.forename: P
authors.initials: P
authors.lastname: Plummer
mesh_terms: D000818:Animals; D054991:Autovaccines / Q000008:administration & dosage / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D001835:Body Weight; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D007117:Immunization, Secondary / Q000379:methods; D015994:Incidence; D007279:Injections, Subcutaneous; D007484:Iowa; D007639:Keratoconjunctivitis, Infectious / Q000276:immunology / Q000517:prevention & control*; D009016:Moraxella / Q000276:immunology*; D010919:Placebos / Q000008:administration & dosage; D014922:Wisconsin
chemical_list: D054991:Autovaccines; D001428:Bacterial Vaccines; D010919:Placebos