title: Homology modeling of GPCRs.
abstract: Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.
authors.affiliation: Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Simms
authors.forename: Nathan E
authors.initials: NE
authors.lastname: Hall
authors.forename: Polo H C
authors.initials: PH
authors.lastname: Lam
authors.forename: Laurence J
authors.initials: LJ
authors.lastname: Miller
authors.forename: Arthur
authors.initials: A
authors.lastname: Christopoulos
authors.forename: Ruben
authors.initials: R
authors.lastname: Abagyan
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Sexton
mesh_terms: D000595:Amino Acid Sequence; D019295:Computational Biology; D030562:Databases, Protein; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid
chemical_list: D018343:Receptors, Adrenergic, beta-2; D043562:Receptors, G-Protein-Coupled