Basophils trump dendritic cells as APCs for T(H)2 responses.
Dendritic cells are best known as antigen-presenting cells that initiate adaptive immune responses. Three new papers suggest that basophils initiate allergen- and helminth-driven CD4+ T helper type 2 responses by functioning as antigen-presenting cells in draining lymph nodes.
Wynn
Thomas A
TA
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology; D001491:Basophils / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D018448:Models, Immunological; D018418:Th2 Cells / Q000276:immunology*
D000947:Antigens, Helminth