[Phalanges necrosis--a rare manifestation of "hand-foot" syndrome induced by gemcitabine used in the second--line therapy for progressive ovarian cancer. A case report].
"Hand-foot" syndrome is a well-documented, dermatologic reaction after several chemotherapeutic agents with wild spectrum of symptoms. To the best of our knowledge, palmar-plantar erythrodysesthesia syndrome--presented as irreversible cytotoxic side effect induced by gemcitabine alone--has not been reported so far. We present a case of a patient with a history of peripheral sensory neuropathy who developed a painless finger necrosis caused by gemcitabine used in the second-line therapy for progressive ovary cancer.
Gołka
Karolina Agnieszka
KA
Katedra i Klinika Ginekologii i Ginekologii Onkologicznej Akademii Medycznej w Gdańsku. kgolka@amg.gda.pl
Kobierski
Juliusz
J
Milczek
Tomasz
T
Emerich
Janusz
J
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D050278:Finger Phalanges / Q000473:pathology*; D005533:Foot Dermatoses / Q000139:chemically induced* / Q000517:prevention & control; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D009336:Necrosis / Q000139:chemically induced; D010051:Ovarian Neoplasms / Q000188:drug therapy; D013577:Syndrome; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine