Prospects for antisense peptide nucleic acid (PNA) therapies for HIV.
Since the discovery and synthesis of a novel DNA mimic, peptide nucleic acid (PNA) in 1991, PNAs have attracted tremendous interest and have shown great promise as potential antisense drugs. They have been used extensively as tools for specific modulation of gene expression by targeting translation or transcription processes. This review discusses the present and future therapeutic potential of this class of compound as anti-HIV-1 drugs.
Pandey
Virendra N
VN
University of Medicine and Dentistry, New Jersey-New Jersey Medical School, Department of Biochemistry and Molecular Biology, Newark, NJ 07103, USA. pandey@umdnj.edu
Upadhyay
Alok
A
Chaubey
Binay
B
D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001691:Biological Therapy / Q000379:methods; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002412:Cations; D005786:Gene Expression Regulation; D015316:Genetic Therapy / Q000379:methods*; D015658:HIV Infections / Q000628:therapy*; D016325:HIV Long Terminal Repeat; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D020135:Peptide Nucleic Acids / Q000627:therapeutic use*; D014176:Protein Biosynthesis; D014158:Transcription, Genetic
D019380:Anti-HIV Agents; D002412:Cations; D020135:Peptide Nucleic Acids