title: Effects of topiramate on weight and metabolism in children with epilepsy.
abstract: OBJECTIVE
  To explore the mechanism of topiramate-induced weight loss in epilepsy children by monitoring metabolism indices.
  
  
  METHODS
  Children with epilepsy were treated with topiramate at their first clinical visit. Metabolism indices including body mass index (BMI) and its SD scores, leptin, adiponectin, leptin/adiponectin (L/A), lipid profile-insulin and Homeostasis Model Assessments (HOMA) index were collected before and after treatment.
  
  
  RESULTS
  Topiramate treatment significantly reduced L/A (t = 2.156, p = 0.031), and markedly increased the serum level of adiponectin (t = 3.124, p = 0.002). Moreover, there were no relationships between the metabolism indices and dosages of topiramate (p > 0.05).
  
  
  CONCLUSIONS
  Our studies find that topiramate treatment in epilepsy children increases energy metabolism, resulting in weight loss. It has been demonstrated that adiponectin play a significant role in metabolic regulations.
authors.affiliation: The Children's Hospital Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Hai-feng
authors.initials: HF
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Zou
authors.forename: Zhe-zhi
authors.initials: ZZ
authors.lastname: Xia
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Feng
authors.forename: Cui-wei
authors.initials: CW
authors.lastname: Yang
mesh_terms: D052242:Adiponectin / Q000097:blood; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001786:Blood Glucose; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D016022:Case-Control Studies; D002648:Child; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008660:Metabolism / Q000187:drug effects; D018709:Statistics, Nonparametric; D000077236:Topiramate
chemical_list: D052242:Adiponectin; D019440:Anti-Obesity Agents; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D008055:Lipids; D000077236:Topiramate; D005632:Fructose