Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the nucleus raphe magnus to participate in pain modulation.
Hypothalamic paraventricular nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion. AVP is the most important bioactive substance in PVN regulating pain process. Our previous study has pointed that pain stimulation induced AVP increase in the nucleus raphe magnus (NRM), which plays a role in pain modulation. The present study was designed to investigate the source of AVP in the rat NRM during pain process using the methods of nucleus push-pull perfusion and radioimmunoassay. The results showed that pain stimulation increased the AVP concentration in the NRM perfusion liquid, PVN cauterization inhibited the role that pain stimulation induced the increase of AVP concentration in the NRM perfusion liquid, and PVN microinjection of L-glutamate sodium, which excited the PVN neurons, could increase the AVP concentration in the NRM perfusion liquid. The data suggested that AVP in the PVN might be transferred to the NRM to participate in pain modulation.
Yang
Jun
J
State Key Laboratory of New Technology for Pharmaceuticals, Jiangsu Provincial Institute for Novel Pharmaceuticals at Taizhou, Yangtze River Pharmaceutical Group, 1 Yangtze River South Road, Taizhou, Jiangsu, China. yj6676@yahoo.com
Yuan
Huifeng
H
Liu
Wenyan
W
Song
Chaoyou
C
Xu
Hongtao
H
Wang
Gen
G
Song
Cai
C
Ni
Na
N
Yang
Daiwei
D
Lin
Baocheng
B
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology*; D002425:Cautery; D018698:Glutamic Acid / Q000494:pharmacology; D008297:Male; D010146:Pain / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism* / Q000601:surgery; D010477:Perfusion; D011903:Raphe Nuclei / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001127:Arginine Vasopressin; D018698:Glutamic Acid