title: Tissue Doppler imaging must be performed to detect early left ventricular dysfunction in patients with type 1 diabetes mellitus.
abstract: OBJECTIVE
  We sought to compare diastolic parameters in patients having type 1 diabetes mellitus (DM) and healthy controls using both pulse-wave (PW) Doppler and relatively novel tissue-Doppler imaging (TDI) to evaluate the possible effect of diabetes on left ventricular dysfunction.
  
  
  RESULTS
  One hundred and thirty-two patients were evaluated (81 type 1 diabetic patients and 51 healthy volunteers). The detailed M-mode, two-dimensional, colour Doppler; PW Doppler; and TDI analyses were performed on resting subjects in a regular setting. Posterior wall thickness, left atrial indexed diameter, and A velocity were significantly higher in the diabetics when compared with control group (P = 0.019, <0.001, 0.033, respectively). Rest of the M-mode and PW Doppler parameters of diabetics were comparable with those of control subjects (P > 0.05 for all). However, both septal E' and lateral E' velocities were significantly lower in diabetics than in the control subjects on TDI echocardiographic examination (P < 0.001 and 0.011, respectively). In addition, E'/septal E' and E/lateral E' ratios were significantly higher in the diabetic group (P < 0.001 and 0.008, respectively).
  
  
  CONCLUSIONS
  TDI is a more accurate and powerful method than PW or M-mode in determination of early cardiac involvement related to type 1 DM even in the subclinical phase as well as hereditary cardiomyopathies.
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Kamile
authors.initials: K
authors.lastname: Gul
authors.forename: Aksuyek Savas
authors.initials: AS
authors.lastname: Celebi
authors.forename: Fehmi
authors.initials: F
authors.lastname: Kacmaz
authors.forename: Ozlem Celebi
authors.initials: OC
authors.lastname: Ozcan
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ustun
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Aydin
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi
authors.forename: Serdar
authors.initials: S
authors.lastname: Guler
authors.forename: Ayse Ozden
authors.initials: AO
authors.lastname: Barazi
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology