title: Myocardial T2* mapping free of distortion using susceptibility-weighted fast spin-echo imaging: a feasibility study at 1.5 T and 3.0 T.
abstract: This study demonstrates the feasibility of applying free-breathing, cardiac-gated, susceptibility-weighted fast spin-echo imaging together with black blood preparation and navigator-gated respiratory motion compensation for anatomically accurate T2* mapping of the heart. First, T2* maps are presented for oil phantoms without and with respiratory motion emulation T2* = (22.1 +/- 1.7) ms at 1.5 T and T2* = (22.65 +/- 0.89) ms at 3.0 T). T2* relaxometry of a ferrofluid revealed relaxivities of R2* = (477.9 +/- 17) mM(-1)s(-1) and R2* = (449.6 +/- 13) mM(-1)s(-1) for UFLARE and multiecho gradient-echo imaging at 1.5 T. For inferoseptal myocardial regions mean T2* values of 29.9 +/- 6.6 ms (1.5 T) and 22.3 +/- 4.8 ms (3.0 T) were estimated. For posterior myocardial areas close to the vena cava T2*-values of 24.0 +/- 6.4 ms (1.5 T) and 15.4 +/- 1.8 ms (3.0 T) were observed. The merits and limitations of the proposed approach are discussed and its implications for cardiac and vascular T2*-mapping are considered.
authors.affiliation: Department of Diagnostic Radiology, RWTH Aachen University, University Hospital, Aachen, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Heinrichs
authors.forename: Jane F
authors.initials: JF
authors.lastname: Utting
authors.forename: Tobias
authors.initials: T
authors.lastname: Frauenrath
authors.forename: Fabian
authors.initials: F
authors.lastname: Hezel
authors.forename: Gabriele A
authors.initials: GA
authors.lastname: Krombach
authors.forename: Michael A J
authors.initials: MA
authors.lastname: Hodenius
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kozerke
authors.forename: Thoralf
authors.initials: T
authors.lastname: Niendorf
mesh_terms: D000465:Algorithms; D016477:Artifacts; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D005240:Feasibility Studies; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
chemical_list: D013113:Spin Labels