title: Potassium dichromate-induced changes on urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes.
abstract: It has been reported that potassium dichromate-induced nephrotoxicity is evidenced by diminution in creatinine clearance, increase in urinary protein, and structural damage to the proximal tubules. Damage to tissue often leads to the release of enzymes from the injured cells into the extracellular fluids. The aim of this study was to establish whether potassium dichromate induces changes in the urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes. Our results show that the administration of a single intraperitoneal dose of potassium dichromate decreased the activity of such enzymes in urine.
authors.affiliation: Departamentos de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, México. luciobecerratorres@hotmail.com
authors.forename: Sergio Lucio
authors.initials: SL
authors.lastname: Becerra-Torres
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Rodríguez-Vázquez
authors.forename: Iliana Ernestina
authors.initials: IE
authors.lastname: Medina-Ramírez
authors.forename: Fernando
authors.initials: F
authors.lastname: Jaramillo-Juárez
mesh_terms: D000818:Animals; D018826:CD13 Antigens / Q000187:drug effects* / Q000378:metabolism / Q000652:urine; D004785:Environmental Pollutants / Q000633:toxicity; D007274:Injections, Intraperitoneal; D008297:Male; D011192:Potassium Dichromate / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D005723:gamma-Glutamyltransferase / Q000187:drug effects* / Q000378:metabolism / Q000652:urine
chemical_list: D004785:Environmental Pollutants; D005723:gamma-Glutamyltransferase; D018826:CD13 Antigens; D011192:Potassium Dichromate