Investigation of changes in NO content during long-term sensitization in edible snail using EPR-spectroscopy: effects of antibodies to calcium-binding protein S-100.
EPR-spectroscopy experiments (electron paramagnetic resonance) demonstrated a decrease in NO production in the nervous system and heart of edible snail Helix lucorum after formation of long-term sensitization, a neurobiological model of anxiety and depression. The protective effect of antibodies to Ca(2+)-binding protein S-100 in dilution of 10(-12) on the formation of long-term sensitization was accompanied by partial recovery of NO synthesis in the nervous system and heart. These findings indicate that the imbalance in Ca(2+)-binding protein S-100 can lead to inhibition or modulation of some processes during plastic reorganization in the body and especially during pathological processes.
Gainutdinov
Kh L
KhL
E. K. Zavoiskii Kazan' Physicotechnical Institute, Russian Academy of Sciences, Novosibirsk, Russia. gainutdinov@mail.knc.ru
Andrianov
V V
VV
Gainutdinova
T Kh
TKh
Muranova
L N
LN
Obynochny
A A
AA
Timoshenko
A Kh
AKh
Shtark
M B
MB
Epstein
O I
OI
Yurtaeva
S V
SV
Jafarova
G G
GG
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism*; D009418:S100 Proteins / Q000276:immunology*
D000906:Antibodies; D009418:S100 Proteins; D009569:Nitric Oxide