Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain.
We studied the effect of corticotropin-like intermediate lobe peptide (CLIP) on presynaptic NMDA receptors and postsynaptic GABA, NMDA, and AMPA receptors in rat brain. CLIP inhibited presynaptic and postsynaptic NMDA receptors, but potentiated postsynaptic GABA and AMPA receptors. Our results indicate that CLIP modulates function of ionotropic receptors for glutamate and GABA.
Grigoriev
V V
VV
Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy Sciences, Chernogolovka, Moscow Region, Russia. grigor@ipac.ac.ru
Petrova
L N
LN
Ivanova
T A
TA
Gabreliyan
A V
AV
Serkova
T P
TP
D000818:Animals; D000831:Animals, Newborn; D053497:Corticotropin-Like Intermediate Lobe Peptide / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000187:drug effects; D018079:Receptors, GABA / Q000187:drug effects*; D017470:Receptors, Glutamate / Q000187:drug effects*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D018091:Receptors, AMPA; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D053497:Corticotropin-Like Intermediate Lobe Peptide