[Research of cellular toxic effect to Hep-2 of recombinant toxin MSH-Ang].
OBJECTIVE
To study the cytotoxicity of recombinate toxin MSH-Ang to Hep-2.


METHODS
The depurated MSH-Ang were applied in cytotoxicity experiment, and the growth inhibiting action to laryngeal carcinoma cell Hep-2 were observed.


RESULTS
Recombination protein inhibited the growth of laryngeal carcinoma cell Hep-2, and its inhibiting action enhanced and corpuscular mortality rate increased along with the concentration increasing.


CONCLUSIONS
Recombinant toxin MSH-Ang can not only take special effect in tumors with high MSHR, but also target to many other popular tumors.
Zhou
Weiguo
W
Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University Tongren Hospital, Beijing, 100730, China. zhouweiguosky@sohu.com
Ni
Xin
X
Huang
Zhigang
Z
Fang
Jugao
J
Han
Demin
D
Zhu
Dongdong
D
Dong
Zhen
Z
Yang
Zhanquan
Z
D042682:Angiopoietins / Q000235:genetics / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005818:Genetic Engineering; D006801:Humans; D007822:Laryngeal Neoplasms; D009074:Melanocyte-Stimulating Hormones / Q000235:genetics / Q000494:pharmacology*; D011995:Recombination, Genetic
D042682:Angiopoietins; D009074:Melanocyte-Stimulating Hormones