Novel Mi-2 related ATP-dependent chromatin remodelers.
Distinct chromatin remodeling complexes can share a common ATPase subunit. The functional characteristics of each remodeling complex are determined by the respective ATPase-associated subunits. The Mi-2 nucleosome remodeling ATPase has so far only been shown to reside within Nucleosome Remodeling and Deacetylase (NuRD) complexes. Here we will review the recent discovery of two Mi-2 related remodelers that function independently of NuRD and that act as SUMO (small ubiquitin-related modifier)-dependent corepressors: First, Mi-2 exists in a novel chromatin remodeling complex, dMec, that does not rely on histone deacetylation to effect transcriptional repression of proneural genes. Second, the Mi-2 related factor dCHD3 acts as a monomer and does not associate with additional subunits in vivo. These recent results have uncovered an unanticipated complexity in the composition and function of CHD (Chromodomain-Helicase-DNA-binding) complexes.
Kunert
Natascha
N
Institut für Molekularbiologie und Tumorforschung, Universität Marburg, Marburg 35032, Germany.
Brehm
Alexander
A
D000251:Adenosine Triphosphatases / Q000378:metabolism / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001324:Autoantigens / Q000378:metabolism / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000235:genetics; D042002:Chromatin Assembly and Disassembly; D004265:DNA Helicases / Q000378:metabolism / Q000502:physiology; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology*; D044127:Epigenesis, Genetic; D006655:Histone Deacetylases / Q000378:metabolism / Q000502:physiology; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex; D012097:Repressor Proteins / Q000378:metabolism / Q000502:physiology; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology
D001324:Autoantigens; D029721:Drosophila Proteins; C116095:Mi-2 protein, Drosophila; D012097:Repressor Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D006655:Histone Deacetylases; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex; D000251:Adenosine Triphosphatases; C528126:CHD3 protein, Drosophila; D004265:DNA Helicases