title: [Medical and biological safety assessment of genetically modified maize event MIR604].
abstract: There are presented the results of genotoxicologic, immunologic and allergologic examinations which were conducted within the framework of integrated medical and biological assessment of genetically modified rootworm Diabrotica spp.-protected maize event MIR604. Analysis of damages of DNA and structural chromosome aberrations, assessment of the allergenic potential and immunoreactive properties has not confirmed any genotoxic, allergenic and immunotoxic effect of maize event MIR604.
authors.forename: N V
authors.initials: NV
authors.lastname: Tyshko
authors.forename: M V
authors.initials: MV
authors.lastname: Britsina
authors.forename: I V
authors.initials: IV
authors.lastname: Gmoshinskiĭ
authors.forename: A K
authors.initials: AK
authors.lastname: Zhanataev
authors.forename: N S
authors.initials: NS
authors.lastname: Zakharova
authors.forename: S N
authors.initials: SN
authors.lastname: Zorin
authors.forename: V K
authors.initials: VK
authors.lastname: Mazo
authors.forename: M N
authors.initials: MN
authors.lastname: Ozeretskovskaia
authors.forename: B F
authors.initials: BF
authors.lastname: Semenov
mesh_terms: D000707:Anaphylaxis / Q000209:etiology / Q000276:immunology; D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism / Q000648:ultrastructure; D002869:Chromosome Aberrations; D003106:Colon / Q000378:metabolism; D020552:Comet Assay; D004249:DNA Damage; D005504:Food Analysis / Q000379:methods*; D005512:Food Hypersensitivity / Q000209:etiology*; D030841:Food, Genetically Modified / Q000009:adverse effects / Q000592:standards / Q000633:toxicity*; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010047:Ovalbumin; D030821:Plants, Genetically Modified / Q000009:adverse effects / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D018675:Toxicity Tests; D003313:Zea mays / Q000009:adverse effects / Q000235:genetics* / Q000592:standards / Q000633:toxicity*
chemical_list: D010047:Ovalbumin