title: Acute effects of intravenously administered ethanol on retinal vessel diameters and flicker induced vasodilatation in healthy volunteers.
abstract: There is evidence from several vascular beds that acute alcohol consumption causes ocular hypotension and peripheral vasodilatation. The current study investigated the effects of intravenously administered ethanol on retinal vessel diameters and on flicker induced retinal vasodilatation. For this purpose, ethanol (0.35 g/kg) or placebo (physiologic saline solution) was administered intravenously for 40 min in a randomized, double masked, two way cross-over design to 12 healthy male volunteers. Retinal vessel diameters and flicker induced vasodilatation were measured before administration of ethanol as well as 30, 50, 90 and 130 min after the start of infusion with a retinal vessel analyzer. Intraocular pressure, systemic blood pressure and blood ethanol concentration were determined at the same time points. Intravenous administration of ethanol increased blood ethanol concentration from 0.0 g/l to 0.56+/-0.10 g/l. Ethanol reduced IOP, but did not change ocular perfusion pressure. After cessation of the infusion blood ethanol concentration started to drop reaching a blood ethanol concentration of 0.22+/-0.06 g/l 130 min after the start of infusion. Retinal arterial diameters increased significantly after administration of ethanol by a maximum of +4.2+/-4.0%, whereas no change was observed in retinal veins. Neither arterial nor venous diameters were influenced by administration of placebo. Flicker stimulation induced a significant dilatation in both arterial and venous diameters. Ethanol did not change flicker responses in arteries or in retinal veins. In conclusion, intravenous administration of ethanol increases retinal arterial diameters, whereas venous diameters remained unchanged. Whether this is related to a direct vasodilator effect or to a hitherto unidentified mechanism remains to be clarified.
authors.affiliation: Department of Clinical Pharmacology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Luksch
authors.forename: Hemma
authors.initials: H
authors.lastname: Resch
authors.forename: Günther
authors.initials: G
authors.lastname: Weigert
authors.forename: Stefan
authors.initials: S
authors.lastname: Sacu
authors.forename: Leopold
authors.initials: L
authors.lastname: Schmetterer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Garhöfer
mesh_terms: D000328:Adult; D001794:Blood Pressure; D018592:Cross-Over Studies; D004311:Double-Blind Method; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D016032:Randomized Controlled Trials as Topic; D012171:Retinal Vessels / Q000502:physiology*; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D000431:Ethanol