[Physiopathological mechanism of hot flushes-perspiration induced by androgen deprivation in prostate carcinoma].
Hot flushes and perspiration are common problems during androgen deprivation therapy for prostate carcinoma, and largely contribute to worsen patient quality of life. Different hypotheses have been proposed to explain the underlying physiopathological mechanisms, though all are very complex, basically because of the multiple causal factors involved. The present review offers a pondered and updated perspective of the origin of hot flushes-perspiration in such patients. Negative feedback of the plasma sexual hormones upon the hypothalamic secretion of noradrenalin and serotonin appears to be the main cause. Likewise, the direct action of such mechanisms upon the LH-RH producing hypothalamic center located close to the thermoregulatory center, together with shortening of the thermoneutral interval, would also play a role. Improved understanding of the causal mechanism may help improve the treatment of such symptoms.
Vilar Gónzalez
Santiago
S
Servicio de Radioterapia, Complejo Hospitalario Universitario de Albacete (CHUA), España. santiagov06@gmail.com
Montañá Puig
Francesc
F
Villas Sánchez
Ma Victoria
MV
Sevillano Capellán
Ma del Mar
Mdel M
Aguayo Martos
Manuel
M
Sabater Martí
Sebastiá
S
D000726:Androgen Antagonists / Q000009:adverse effects*; D019584:Hot Flashes / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009919:Orchiectomy / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000503:physiopathology* / Q000628:therapy*; D013546:Sweating
D000726:Androgen Antagonists