No association of DPP6 with amyotrophic lateral sclerosis in an Italian population.
We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.
Fogh
Isabella
I
MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, UK. I.Fogh@iop.kcl.ac.uk
D'Alfonso
Sandra
S
Gellera
Cinzia
C
Ratti
Antonia
A
Cereda
Cristina
C
Penco
Silvana
S
Corrado
Lucia
L
Sorarù
Gianni
G
Castellotti
Barbara
B
Tiloca
Cinzia
C
Gagliardi
Stella
S
Cozzi
Lorena
L
Lupton
Michelle K
MK
Ticozzi
Nicola
N
Mazzini
Letizia
L
Shaw
Chris E
CE
Al-Chalabi
Ammar
A
Powell
John
J
Silani
Vincenzo
V
D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D015331:Cohort Studies; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007558:Italy; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015221:Potassium Channels / Q000235:genetics*
D009419:Nerve Tissue Proteins; D015221:Potassium Channels; C503535:DPP6 protein, human; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases