Variation in genomic recombination rates among heterogeneous stock mice.
We used a large panel of pedigreed, genetically admixed house mice to study patterns of recombination rate variation in a leading mammalian model system. We found considerable inter-individual differences in genomic recombination rates and documented a significant heritable component to this variation. These findings point to clear variation in recombination rate among common laboratory strains, a result that carries important implications for genetic analysis in the house mouse.
Dumont
Beth L
BL
Laboratory of Genetics, University of Wisconsin, Madison, 53706, USA.
Broman
Karl W
KW
Payseur
Bret A
BA
D000818:Animals; D016678:Genome; D007700:Kinetics; D051379:Mice / Q000235:genetics*; D011995:Recombination, Genetic