title: A highly enantioselective allylic amination reaction using a commercially available chiral rhodium catalyst: resolution of racemic allylic carbonates.
abstract: A novel method for the kinetic resolution of unsymmetrical acyclic allylic carbonates and the concurrent synthesis of enantioenriched secondary amines using a commercially available chiral catalyst is disclosed.
authors.affiliation: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA. derek.vrieze@pfizer.com
authors.forename: Derek C
authors.initials: DC
authors.lastname: Vrieze
authors.forename: Garrett S
authors.initials: GS
authors.lastname: Hoge
authors.forename: Perrine Z
authors.initials: PZ
authors.lastname: Hoerter
authors.forename: Jared T
authors.initials: JT
authors.lastname: Van Haitsma
authors.forename: Brian M
authors.initials: BM
authors.lastname: Samas
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D000588:Amines; D002254:Carbonates; D012238:Rhodium