title: Advancing genetic theory and application by metabolic quantitative trait loci analysis.
abstract: This review describes recent advances in the analysis of metabolism using quantitative genetics. It focuses on how recent metabolic quantitative trait loci (QTL) studies enhance our understanding of the genetic architecture underlying naturally variable phenotypes and the impact of this fundamental research on agriculture, specifically crop breeding. In particular, the role of whole-genome duplications in generating quantitative genetic variation within a species is highlighted and the potential uses of this phenomenon presented. Additionally, the review describes how new observations from metabolic QTL mapping analyses are helping to shape and expand the concepts of genetic epistasis.
authors.affiliation: Genetics Graduate Group and Department of Plant Sciences, University of California, Davis, California 95616, USA. kliebenstein@ucdavis.edu
authors.forename: Danielj
authors.initials: D
authors.lastname: Kliebenstein
mesh_terms: D002874:Chromosome Mapping; D018556:Crops, Agricultural / Q000235:genetics* / Q000378:metabolism; D004843:Epistasis, Genetic; D020440:Gene Duplication; D005810:Multigene Family; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D040641:Quantitative Trait Loci; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D010940:Plant Proteins; D014157:Transcription Factors