Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells.
A new compound, named quinquefoloside-L(c) (1), together with nine known compounds, was isolated from leaves of Panax quinquefolium, and its structure was elucidated as 3beta,12beta, 20S-trihydroxy-25-methoxydammar-23-ene 3-O-beta-D-glucopyranosyl (1-->2)beta-D-glucopyranosyl-20-O-beta-D-xylopyanosyl (1-->6) beta-D-glucopyranoside (1), on the basis of MS, 1D-and 2D-NMR experiments as well as by chemical degradation. The cytotoxicity of these compounds against human breast cancer MCF-7 cell line was also tested by MTT method.
Qiu
Ying-Kun
YK
College of Pharmacy, Liaoning University of Traditional Chinese Medicine, DD Port, Dalian Economic and Technical Development Zone, 116600 Dalian, China.
Dou
De-Qiang
DQ
Cai
Li-Ping
LP
Jiang
Hai-Ping
HP
Kang
Ting-Guo
TG
Yang
Bing-You
BY
Kuang
Hai-Xue
HX
Li
Michael Zc
MZ
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D005260:Female; D036145:Ginsenosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D012503:Saponins / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D036145:Ginsenosides; D010936:Plant Extracts; D012503:Saponins; C553850:quinquefoloside-L(c)