Novel 3,3'-diindolylmethane derivatives: synthesis and cytotoxicity, structural characterization in solid state.
A series of 3,3'-dindolylmethane derivatives have been synthesized and their structures were characterized in solid state by (13)C CP/MAS NMR and two of them by X-ray diffraction measurements. They exhibited well expressed cytotoxicity against human melanoma cell lines. Derivatives bearing fluoro, bromo, iodo, and nitro substituents in indole or benzene rings caused 50% inhibition of the viability of ME18 and ME18/R cell lines at concentration ranging 9.7-17.3 microM.
Maciejewska
Dorota
D
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 02 097 Warsaw, Poland. domac@farm.amwaw.edu.pl
Rasztawicka
Magdalena
M
Wolska
Irena
I
Anuszewska
Elzbieta
E
Gruber
Beata
B
D016588:Anticarcinogenic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000188:drug therapy; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
D016588:Anticarcinogenic Agents; D007211:Indoles; C016392:3,3'-diindolylmethane