title: Metabolism of tributyltin and triphenyltin by Dall's porpoise hepatic microsomes.
abstract: The in vitro metabolism of tributyltin (TBT) and triphenyltin (TPT) by the hepatic microsomal cytochrome P-450 system enzymes of Dall's porpoises (Phocoenoides dalli) was comparatively elucidated with those enzymes of the Sprague Dawley rat in the present study. Our results suggested firstly a limited metabolic capacity for TBT and especially TPT to their metabolites in the Dall's porpoises, and documented a similar mechanism of a relatively stronger metabolic rate of TBT to its metabolites than that of TPT in the microsome of porpoises and rat. However, the metabolic capacity to degrade both TBT and TPT were much lower in the microsome of porpoises than that in the rats.
authors.affiliation: Key Laboratory of Ecological Environment and Resources of Inland Fisheries, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Shanshui East Road No. 9, Wuxi City, Jiangsu 214081, China. jiany@ffrc.cn
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Yuji
authors.initials: Y
authors.lastname: Oshima
authors.forename: Ito
authors.initials: I
authors.lastname: Sei
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyazaki
mesh_terms: D000818:Animals; D008862:Microsomes, Liver / Q000378:metabolism*; D009947:Organotin Compounds / Q000378:metabolism*; D019576:Porpoises / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014220:Trialkyltin Compounds / Q000378:metabolism*
chemical_list: D009947:Organotin Compounds; D014220:Trialkyltin Compounds; C011559:tributyltin; C030665:triphenyltin