Mitogen-activated protein kinases and Wnt/beta-catenin signaling: Molecular conversations among signaling pathways.
Wnt/beta-catenin canonical pathway is critical for normal embryonic development; mutations and aberrant expression of specific components of this pathway can be oncogenic. Mitogen-activated protein kinase (MAPK) pathways, prominent in intracellular signaling, have been shown to have unique and provocative roles that impact the Wnt/beta-catenin signaling. We discuss recent insights that implicate the three major pathways of the MAPK network, i.e., mediated by p38, c-Jun N-terminal (JNK) kinase and Extra-cellular-Regulated Kinases (ERK) and their downstream signaling elements in Wnt/beta-catenin signaling. Novel "crosstalk" among MAPK and Wnt/beta-catenin canonical signaling pathways is essential. A fuller understanding of how such signaling is integrated during development is a high-value target for future research.
Bikkavilli
Rama Kamesh
RK
Department of Pharmacology; Health Sciences Center; State University of New York at Stony Brook; Stony Brook, New York USA.
Malbon
Craig C
CC