title: Proteomics in protein misfolding diseases.
abstract: Protein misfolding and deposition as amyloid, with consequent tissue damage, plays a key role in the group of diseases generically termed amyloidoses. In the systemic forms, amyloid deposition is widespread and causes severe dysfunction of vital organs. Proteomic analysis, thanks to its versatility and the comprehensiveness of information obtained, is an ideal tool for the study of systemic amyloidoses. It has been successfully employed in the characterization of the circulating amyloidogenic precursors and the analysis of affected tissues, for the diagnostic identification of the fibril components and for characterizing disease-related changes in protein expression. We present the developments in the field of proteomics applied to systemic amyloidoses, and discuss the perspectives opened in the study of these diseases.
authors.affiliation: Department of Biochemistry, University of Pavia, Pavia, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Stoppini
authors.forename: Laura
authors.initials: L
authors.lastname: Obici
authors.forename: Francesca
authors.initials: F
authors.lastname: Lavatelli
authors.forename: Sofia
authors.initials: S
authors.lastname: Giorgetti
authors.forename: Loredana
authors.initials: L
authors.lastname: Marchese
authors.forename: Remigio
authors.initials: R
authors.lastname: Moratti
authors.forename: Vittorio
authors.initials: V
authors.lastname: Bellotti
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Merlini
mesh_terms: D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D006801:Humans; D017510:Protein Folding; D040901:Proteomics / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000682:Amyloid