[A new approach to clinical and laboratory diagnosis of systemic and local soft tissue infections].
Dynamic measurements of blood TNF-a, IL-IRA, CRP, oligopeptide, and lactoferrin levels in patients with systemic and local soft tissue infections revealed direct correlation between them which allowed to use these indicators for the diagnosis of systemic infections. Results of clinical and laboratory analyses provided a basis for distinguishing short-term systemic inflammatory response syndrome and sepsis and developing relevant diagnostic criteria. Sepsis combined with systemic inflammatory response syndrome persisting for more than 72 hours after the onset of adequate therapy was characterized by CRP levels > 30 mg/l, oligopeptides > 0.34 U, lactoferrin > 1900 ng/ml, TNF-a > 6 pg/ml, ILL-IRA < 1500 pg/ml Patients with systemic inflammatory response syndrome for less than 72 hours had lower TNF-a, CRP, oligopeptide, and lactoferrin levels with IL-IRA > 1500 pg/ml. This new approach to early diagnosis of systemic infections makes it possible to optimize their treatment and thereby enhance its efficiency.
Barkhatova
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D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D019411:Clinical Laboratory Techniques; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood; D007781:Lactoferrin / Q000097:blood; D009842:Oligopeptides / Q000097:blood; D018461:Soft Tissue Infections / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015415:Biomarkers; D053590:Interleukin 1 Receptor Antagonist Protein; D009842:Oligopeptides; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D007781:Lactoferrin