Influence of Hsp70 chaperone machinery on yeast prion propagation.
Chaperones have long been recognised for their essential roles in the cell. They are involved in the refolding or degradation of misfolded proteins as well as the correct folding of newly synthesised proteins. However recent experiments have discovered that chaperones also have an important role to play in the propagation and maintenance of prions in yeast. The following minireview focuses on the Hsp70 chaperone family and it's involvement in the propagation of yeast prions.
Guinan
Emma
E
Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland. emma.guinan@nuim.ie
Jones
Gary W
GW
D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry / Q000502:physiology*; D011328:Prions / Q000502:physiology*; D017510:Protein Folding; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000502:physiology*
D018840:HSP70 Heat-Shock Proteins; D011328:Prions; D029701:Saccharomyces cerevisiae Proteins