title: Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA).
abstract: Common polymorphisms in the transcription factor 7-like 2 gene (TCF7L2) have been associated with type 2 diabetes in different populations and recently with LADA, but not with type 1 diabetes. The aim of our study was to investigate association between the rs7903146 polymorphism in the TCF7L2 gene and LADA in Polish patients. Link between the "high risk for type 2 diabetes genotype" with clinical features was analyzed. 68 newly diagnosed patients with LADA and 195 healthy controls were genotyped for the rs7903146 polymorphism in the TCF7L2 gene using the PCR-based RFLP method. Fasting C peptide level was measured by ELISA. We observed increased frequencies of the TT genotype of the rs7903146 polymorphism in the TCF7L2 gene in LADA patients compared to controls (15 vs. 6%, P = 0.03). Fasting C peptide serum concentration was significantly lower in group of patients with LADA carrying the TT genotype (P < 0.01). In conclusion, the data from this study confirmed previous results showing genetic similarities between patients with LADA and type 2 diabetes. Non-autoimmune mechanism may be related to beta cell dysfunction in patients with LADA.
authors.affiliation: Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. barbara.szepietowska@yale.edu
authors.forename: Barbara
authors.initials: B
authors.lastname: Szepietowska
authors.forename: Dariusz
authors.initials: D
authors.lastname: Moczulski
authors.forename: Natalia
authors.initials: N
authors.lastname: Wawrusiewicz-Kurylonek
authors.forename: Wladyslaw
authors.initials: W
authors.lastname: Grzeszczak
authors.forename: Maria
authors.initials: M
authors.lastname: Gorska
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Szelachowska
mesh_terms: D000328:Adult; D002096:C-Peptide / Q000097:blood*; D017931:DNA Primers; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D018450:Disease Progression; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D012016:Reference Values; D051820:TCF Transcription Factors / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein
chemical_list: D002096:C-Peptide; D017931:DNA Primers; D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein