title: Thermal interaction of short-pulsed laser focused beams with skin tissues.
abstract: Time-dependent thermal interaction is developed in a skin tissue cylinder subjected to the irradiation of a train of short laser pulses. The skin embedded with a small tumor is stratified as three layers: epidermis, dermis and subcutaneous fat with different optical, thermal and physiological properties. The laser beam is focused to the tumor site by an objective lens for thermal therapy. The ultrafast radiation heat transfer of the focused beam is simulated by the transient discrete ordinates method. The transient Pennes bio-heat equation is solved numerically by the finite volume method with alternating direction implicit scheme. Emphasis is placed on the characterization of the focused beam propagation and absorption and the temperature rise in the focal spot. The effects of the focal spot size and location, the laser power, and the bio-heat equation are investigated. Comparisons with collimated irradiation are conducted. The focused beam can penetrate a greater depth and produce higher temperature rise at the target area, and thus reduce the possibility of thermal damage to the surrounding healthy tissue. It is ideal for killing cancerous cells and small tumors.
authors.affiliation: Department of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. guo@jove.rutgers.edu
authors.forename: Jian
authors.initials: J
authors.lastname: Jiao
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000818:Animals; D003198:Computer Simulation; D062109:Dermatologic Surgical Procedures; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D007834:Lasers; D008954:Models, Biological; D011829:Radiation Dosage; D012881:Skin Temperature / Q000502:physiology* / Q000528:radiation effects*; D025321:Surgery, Computer-Assisted / Q000379:methods*