title: A bioactive coating of a silica xerogel/chitosan hybrid on titanium by a room temperature sol-gel process.
abstract: A bioactive coating consisting of a silica xerogel/chitosan hybrid was applied to Ti at room temperature as a novel surface treatment for metallic implants. A crack-free thin layer (<2 microm) was coated on Ti with a chitosan content of >30 vol.% through a sol-gel process. The coating layer became more hydrophilic with increasing silica xerogel content, as assessed by contact angle measurement. The hybrid coatings afforded excellent bone bioactivity by inducing the rapid precipitation of apatite on their surface when immersed in a simulated body fluid (SBF). Osteoblastic cells cultured on the hybrid coatings were more viable than those on a pure chitosan coating. Furthermore, the alkaline phosphate activity of the cells was significantly higher on the hybrid coatings than on a pure chitosan coating, with the highest level being achieved on the hybrid coating containing 30% chitosan. These results indicate that silica xerogel/chitosan hybrids are potentially useful as room temperature bioactive coating materials on titanium-based medical implants.
authors.affiliation: Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
authors.forename: Shin-Hee
authors.initials: SH
authors.lastname: Jun
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Lee
authors.forename: Se-Won
authors.initials: SW
authors.lastname: Yook
authors.forename: Hyoun-Ee
authors.initials: HE
authors.lastname: Kim
authors.forename: Hae-Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Young-Hag
authors.initials: YH
authors.lastname: Koh
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids; D018929:Cell Culture Techniques / Q000295:instrumentation; D048271:Chitosan / Q000737:chemistry*; D005782:Gels; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000378:metabolism*; D044367:Phase Transition; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D012822:Silicon Dioxide; D048271:Chitosan; D014025:Titanium