Response of an adult patient with pineoblastoma to vorinostat and retinoic acid.
We report the case of an adult patient with pineoblastoma (PBL) who had a complete radiographic response following treatment with vorinostat and retinoic acid. This regimen was used to treat bulky residual tumor that persisted despite radiation therapy (RT) and two cycles of cytotoxic chemotherapy. Vorinostat and retinoic acid were chosen as an alternative to cytotoxic chemotherapy, which our patient was unable to tolerate, based on preclinical data suggesting efficacy of this combination. MRI demonstrated a complete response to this regimen, which continues to remain stable without evidence of recurrence.
DeBoer
Rebecca
R
Feinberg School of Medicine, Northwestern University, 710 N. Lake Shore Drive, Abbott Hall, Room 1123, Chicago, IL, 60611, USA. becky.deboer@gmail.com.
Batjer
Hunt
H
Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 675 North St. Clair St. Suite 20-250, Chicago, IL, 60611, USA.
Marymont
Maryanne
M
Radiation Oncology, Feinberg School of Medicine, Northwestern University, 251 East Huron Street, Galter LC-178, Chicago, IL, 60611, USA.
Goldman
Stewart
S
Medical Neuro-Oncology, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, 2300 Children's Plaza, Chicago, IL, 60614, USA.
Walker
Matthew
M
Department of Radiology, Feinberg School of Medicine, Northwestern University, 676 North St. Clair St. Suite 800, Chicago, IL, 60611, USA.
Gottardi-Littell
Numa
N
Department of Pathology, Feinberg School of Medicine, Northwestern University, 710 N. Fairbanks Court, Olson 2-458, Chicago, IL, 60611, USA.
Raizer
Jeffrey
J
Medical Neuro-Oncology, Feinberg School of Medicine, Northwestern University, 710 N. Lake Shore Drive, Abbott Hall, Room 1123, Chicago, IL, 60611, USA.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D003131:Combined Modality Therapy; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage; D008297:Male; D010870:Pineal Gland; D010871:Pinealoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D011379:Prognosis; D011879:Radiotherapy Dosage; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage; D000077337:Vorinostat
D006877:Hydroxamic Acids; D014212:Tretinoin; D000077337:Vorinostat