title: Effect of silica gel on the cohesion, properties and biological performance of brushite cement.
abstract: The cohesion of calcium phosphate cements can be improved by the addition of substances to either the solid or liquid phase during the setting reaction. This study reports the effect of silica gel on brushite cement cohesion. The cement was prepared using a mixture of beta-tricalcium phosphate (beta-TCP) and monocalcium phosphate monohydrate as the solid phase, while the liquid phase comprised carboxylic acids silica gel. This cement presents a shorter final setting time (FST), better cohesion and higher amount of unreacted beta-TCP than the cement prepared without silica gel. Furthermore, in vivo experiments using rabbits as an animal model showed that after 8 weeks of implantation cements modified with silica gel showed a similar new bone formation volume and more remaining graft in comparison with unmodified cements. Thus, the silica gel could be efficiently applied to reduce cement disintegration and to decrease the resorption rate of brushite cements.
authors.affiliation: Departamento de Química-Física II, Facultad de Farmacia, UCM, Plaza: Ramon y Cajal, sn, 28040 Madrid, Spain. mkhresat@farm.ucm.es
authors.forename: Mohammad Hamdan
authors.initials: MH
authors.lastname: Alkhraisat
authors.forename: Carmen
authors.initials: C
authors.lastname: Rueda
authors.forename: Luis Blanco
authors.initials: LB
authors.lastname: Jerez
authors.forename: Faleh
authors.initials: F
authors.lastname: Tamimi Mariño
authors.forename: Jesus
authors.initials: J
authors.lastname: Torres
authors.forename: Uwe
authors.initials: U
authors.lastname: Gbureck
authors.forename: Enrique
authors.initials: E
authors.lastname: Lopez Cabarcos
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry*; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D005260:Female; D005782:Gels / Q000737:chemistry*; D007249:Inflammation; D008264:Macrophages / Q000378:metabolism; D008422:Materials Testing; D011817:Rabbits; D012822:Silicon Dioxide / Q000737:chemistry*; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D002264:Carboxylic Acids; D005782:Gels; C485817:beta-tricalcium phosphate; D012822:Silicon Dioxide; C494366:calcium phosphate, dibasic, dihydrate