title: Synthesis of novel ribavirin hydrazone derivatives and anti-proliferative activity against A549 lung cancer cells.
abstract: A series of novel ribavirin hydrazone derivatives were synthesized by the reaction of ribavirin hydrazone with benzaldehyde or acetophenone derivatives. The structures of the compounds were determined by IR, (1)H NMR, and HRESIMS. Preliminary biological evaluation showed that one compound (7h) inhibits the growth of A549 cells at 20microM.
authors.affiliation: Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
authors.forename: Wei-Yong
authors.initials: WY
authors.lastname: Liu
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Li
authors.forename: Bao-Xiang
authors.initials: BX
authors.lastname: Zhao
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Shin
authors.forename: Song
authors.initials: S
authors.lastname: Lian
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Miao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000473:pathology*; D012254:Ribavirin / Q000031:analogs & derivatives*
chemical_list: D000970:Antineoplastic Agents; D006835:Hydrazones; D012254:Ribavirin