title: Autologous hematopoietic stem cell transplant in systemic sclerosis: quantitative high resolution computed tomography of the chest scoring.
abstract: OBJECTIVE
  Using high resolution computed tomography (HRCT), to assess the lung involvement outcome after autologous hematopoietic stem cell transplant (AHSCT) in patients with scleroderma (systemic sclerosis, SSc).
  
  
  METHODS
  HCRT scans prospectively performed before (n = 9 patients) and after (n = 47) AHSCT were blindly reviewed by 2 independent investigators using the Wells score.
  
  
  RESULTS
  After a median 60 months' followup, the overall disease extent score from HCRT scans decreased from 10 (0-45) to 4 (0-36) (p = 0.04) 6 months after AHSCT, and thereafter increased up to 36 months and stabilized; the modified Rodnan skin score fell (p < 0.05).
  
  
  CONCLUSIONS
  The extent of SSc lung involvement on HRCT rapidly but transiently regressed after AHSCT.
authors.affiliation: Service de Médecine Interne, Hôpital Claude-Huriez, Université Lille 2, Lille, France.
authors.forename: David
authors.initials: D
authors.lastname: Launay
authors.forename: Zora
authors.initials: Z
authors.lastname: Marjanovic
authors.forename: Cedric
authors.initials: C
authors.lastname: de Bazelaire
authors.forename: Laura
authors.initials: L
authors.lastname: Florea
authors.forename: Sarah
authors.initials: S
authors.lastname: Zohar
authors.forename: Homah
authors.initials: H
authors.lastname: Keshtmand
authors.forename: Christophe
authors.initials: C
authors.lastname: Deligny
authors.forename: Axelle
authors.initials: A
authors.lastname: de Raigniac
authors.forename: Athol U
authors.initials: AU
authors.lastname: Wells
authors.forename: Dominique
authors.initials: D
authors.lastname: Farge
mesh_terms: D000293:Adolescent; D000328:Adult; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000209:etiology; D012595:Scleroderma, Systemic / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult