[Tissue inhibitor of metalloproteinase-1 (TIMP-1) in colorectal cancer: correlation with clinico-morphological factors].
Tissue inhibitor of metalloproteinase-1 (TIMP-1) was identified by enzyme-linked immunosorbent assay in tumor, histologically-unchanged mucosa, and plasma from 100 colorectal cancer patients. A significant increase in TIMP-1 production of up to 27.4-times as high as in adjacent mucosa was found in 92%. That was most pronounced in cases of tumor extension through adjacent tissues and organs. The marker's level was excessively high in 8% only. It remained unchanged in 71% after excision of tumor. Yet, plasma levels of TIMP-1 were significantly higher in patients with distant metastases than in those with locally advanced process. No significant correlation between tumor and circulating TIMP-1 levels was established.
Korotkova
E A
EA
Gershteĭn
E S
ES
Prorokov
V V
VV
Kushlinskiĭ
N E
NE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000201:enzymology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood / Q000378:metabolism*
D014408:Biomarkers, Tumor; D019715:Tissue Inhibitor of Metalloproteinase-1