Knocking in the NLRP3 inflammasome.
Mutations in the human NLRP3 gene cause interleukin-1beta-related autoinflammatory syndromes. In this issue of Immunity, Brydges et al. (2009) and Meng et al. (2009) report the characterization of Nlrp3 gene-targeted mice harboring mutations mimicking those causing disease in humans.
Girardin
Stephen E
SE
Department of Laboratory Medicine and Pathobiology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada. stephen.girardin@utoronto.ca
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D055879:Gene Knock-In Techniques; D007249:Inflammation / Q000235:genetics*; D053583:Interleukin-1beta / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism
D002352:Carrier Proteins; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse