Evaluation of 13-week inhalation toxicity of sec-butanethiol in rats.
The subchronic toxicity of sec-butanethiol was investigated in Sprague-Dawley rats following a 13-week period of repeated inhalation exposure. Four groups of 10 rats of each sex were exposed to sec-butanethiol vapor by whole-body inhalation at 0, 25, 100, or 400 ppm for 6 h per day, 5 days a week over a 13-week period. At 400 ppm, both genders exhibited a decrease in food consumption, although a decrease in the body weight gain was only observed in females. Hematological investigations revealed a decrease in red blood cell, hemoglobin, and hematocrit in both the male and female groups, whilst the female group exhibited an increase in the mean corpuscular volume and a decrease in the mean corpuscular hemoglobin concentration. There was an increase in kidney weight for both genders but the liver weight was only higher in males than controls. Histopathological alterations were found in the kidneys, spleen, and nasal olfactory epithelium. There were no treatment-related effects observed in both genders at 100 ppm. Under the present experimental conditions, the target organs were determined to be the blood cells, the kidneys, the liver, and the nasal turbinates in rats. The no-observed-effect level was considered to be 100 ppm in rats.
Kim
Hyeon-Yeong
HY
Chemical Safety and Health Research Center, Occupational Safety and Health Research Institute, Daejeon, Republic of Korea.
Lee
Sung-Bae
SB
Cho
Hae-Won
HW
Kang
Min-Gu
MG
Yang
Jeong-Sun
JS
Shin
In-Sik
IS
Kim
Jong-Choon
JC
D000280:Administration, Inhalation; D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004909:Erythrocyte Indices / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009831:Olfactory Mucosa / Q000187:drug effects / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013438:Sulfhydryl Compounds / Q000633:toxicity*
D000393:Air Pollutants; D013438:Sulfhydryl Compounds; C025540:n-butyl mercaptan