Enantio- and diastereoselective intermolecular Stetter reaction of glyoxamide and alkylidene ketoamides.
A triazolinylidene carbene catalyzed intermolecular Stetter reaction of glyoxamide and alkylidene ketoamides has been developed. 1,4-Dicarbonyl products are afforded in good to excellent yields, enantioselectivities, and diastereoselectivities. Further derivatization of the products affords useful intermediates for organic synthesis.
Liu
Qin
Q
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
Rovis
Tomislav
T
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D013237:Stereoisomerism; D013453:Sulfonylurea Compounds / Q000737:chemistry*
D000577:Amides; D007659:Ketones; D013453:Sulfonylurea Compounds; C032160:glyoxamide