[Development of ion-sensitivity in-situ gel].
The recent research papers in ion-sensitivity in-situ gel were reviewed on the following aspects: the characteristics of the gel, the polymer, preparation technology as well as the applications of optical, nasal, and oral route of administration. The solution-gel property of transformation of in-situ gel, which has simple preparation, convenient operation, strong affinity and enough retention time with affected part, especially with mucosa. The recent research advances in ion-sensitivity in-situ gel were mainly reviewed from the following aspects: the characteristics of the gel, the polymer, preparation technology as well as the applications of optical, nasal, and oral route of administration. The present problems of in-situ gel and prospective applications in traditional Chinese medicine were also discussed.
Dai
Long
L
Shandong University of Traditional Chinese Medicine, Jinan 250355, China. dailongdailong@263.net
D000464:Alginates / Q000737:chemistry; D000818:Animals; D004333:Drug Administration Routes; D016503:Drug Delivery Systems / Q000379:methods*; D005782:Gels / Q000737:chemistry*; D006801:Humans; D007477:Ions / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D011135:Polysaccharides, Bacterial / Q000737:chemistry
D000464:Alginates; D005782:Gels; D007477:Ions; D011135:Polysaccharides, Bacterial; C048288:gellan gum