title: Short-term aerobic exercise reduces arterial stiffness in older adults with type 2 diabetes, hypertension, and hypercholesterolemia.
abstract: OBJECTIVE The relationship between increased arterial stiffness and cardiovascular mortality is well established in type 2 diabetes. We examined whether aerobic exercise could reduce arterial stiffness in older adults with type 2 diabetes complicated by comorbid hypertension and hyperlipidemia. RESEARCH DESIGN AND METHODS A total of 36 older adults (mean age 71.4 +/- 0.7 years) with diet-controlled or oral hypoglycemic-controlled type 2 diabetes, hypertension, and hypercholesterolemia were recruited. Subjects were randomly assigned to one of two groups: an aerobic group (3 months vigorous aerobic exercise) and a nonaerobic group (no aerobic exercise). Exercise sessions were supervised by a certified exercise trainer three times per week, and a combination of cycle ergometers and treadmills was used. Arterial stiffness was measured using the Complior device. RESULTS When the two groups were compared, aerobic training resulted in a decrease in measures of both radial (-20.7 +/- 6.3 vs. +8.5 +/- 6.6%, P = 0.005) and femoral (-13.9 +/- 6.7 vs. +4.4 +/- 3.3%, P = 0.015) pulse-wave velocity despite the fact that aerobic fitness as assessed by Vo(2max) did not demonstrate an improvement with training (P = 0.026). CONCLUSIONS Our findings indicate that a relatively short aerobic exercise intervention in older adults can reduce multifactorial arterial stiffness (type 2 diabetes, aging, hypertension, and hypercholesterolemia).
authors.affiliation: VITALiTY (Vancouver Initiative to Add Life to Years) Research Laboratory, Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. kmmadden@interchange.ubc.ca
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Madden
authors.forename: Chris
authors.initials: C
authors.lastname: Lockhart
authors.forename: Darcye
authors.initials: D
authors.lastname: Cuff
authors.forename: Tiffany F
authors.initials: TF
authors.lastname: Potter
authors.forename: Graydon S
authors.initials: GS
authors.lastname: Meneilly
mesh_terms: D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D049628:Body Size; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D003925:Diabetic Angiopathies / Q000628:therapy*; D003927:Diet, Diabetic; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006339:Heart Rate; D006801:Humans; D006937:Hypercholesterolemia / Q000628:therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D018579:Patient Selection; D010809:Physical Fitness; D055070:Resistance Training; D014655:Vascular Resistance
chemical_list: D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents