Polymeric nanomedicine for cancer MR imaging and drug delivery.
Multifunctional nanomedicine is emerging as a highly integrated platform that allows for molecular diagnosis, targeted drug delivery, and simultaneous monitoring and treatment of cancer. Advances in polymer and materials science are critical for the successful development of these multi-component nanocomposites in one particulate system with such a small size confinement (<200 nm). Currently, several nanoscopic therapeutic and diagnostic systems have been translated into clinical practice. In this feature article, we will provide an up-to-date review on the development and biomedical applications of nanocomposite materials for cancer diagnosis and therapy. An overview of each functional component, i.e. polymer carriers, MR imaging agents, and therapeutic drugs, will be presented. Integration of different functional components will be illustrated in several highlighted examples to demonstrate the synergy of the multifunctional nanomedicine design.
Khemtong
Chalermchai
C
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Kessinger
Chase W
CW
Gao
Jinming
J
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D008279:Magnetic Resonance Imaging; D050997:Nanomedicine; D009369:Neoplasms / Q000188:drug therapy*; D011108:Polymers / Q000737:chemistry*
D000970:Antineoplastic Agents; D011108:Polymers