title: Intracranial compound odontome.
abstract: An exceedingly rare case of an extragnathic odontome is described arising within the brain. A 10-year-old boy complained of progressive frontal headache for 5 years. Axial computerized tomography the head revealed a solid, calcified lesion with well-defined borders localized in the sellar and suprasellar region composed of multiple calcified structures resembling teeth. The diagnosis was compound odontome. Physical examination and blood analysis revealed hypopituitarism. The patient was submitted for radical tumour resection. He developed persistent diabetes insipidus, hypothyroidism and adrenal insufficiency for which appropriate replacement therapy has been necessary. This case demonstrates that an odontogenic lesion may arise in brain tissues due to the embryological relationship between primordial stomodeum and Rathke's pouch. Its development could be associated with endocrine disturbances.
authors.affiliation: Departamento de Morfologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.
authors.forename: Paulo Rogério
authors.initials: PR
authors.lastname: de Faria
authors.forename: Sérgio Vitorino
authors.initials: SV
authors.lastname: Cardoso
authors.forename: Ademir
authors.initials: A
authors.lastname: Rocha
authors.forename: Débora Cristiane
authors.initials: DC
authors.lastname: Gomes
authors.forename: Samuel Caputo
authors.initials: SC
authors.lastname: de Castro
authors.forename: Adriano Mota
authors.initials: AM
authors.lastname: Loyola
mesh_terms: D001927:Brain Diseases / Q000150:complications / Q000473:pathology* / Q000601:surgery; D002648:Child; D002828:Choristoma / Q000473:pathology* / Q000601:surgery; D003397:Craniopharyngioma / Q000473:pathology / Q000601:surgery; D003919:Diabetes Insipidus / Q000209:etiology / Q000628:therapy; D006222:Hamartoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology / Q000628:therapy; D008297:Male; D009808:Odontogenic Tumors / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery; D014071:Tooth Abnormalities; D016896:Treatment Outcome