title: The role of mitochondria in cellular defense against microbial infection.
abstract: Mitochondria have been long recognized for their key role in the modulation of cell death pathways. Thus, it is therefore not surprising that this organelle represents a recurrent target for pathogenic microbes, aiming to manipulate the fate of the infected host cell. More recently, mitochondria have been shown to serve as a crucial platform for innate immune signaling, as illustrated by the identification of MAVS (also known as IPS-1, VISA and Cardif), NLRX1 and STING as mitochondrial proteins. This review discusses the tight interplay between microbial infection, innate immune signaling and mitochondria.
authors.affiliation: INSERM U542, Hopital Paul Brousse, Batiment Lavoisier, Villejuif Cedex, France. Damien.arnoult@inserm.fr
authors.forename: Damien
authors.initials: D
authors.lastname: Arnoult
authors.forename: Leticia
authors.initials: L
authors.lastname: Carneiro
authors.forename: Ivan
authors.initials: I
authors.lastname: Tattoli
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Girardin
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016923:Cell Death; D006801:Humans; D007113:Immunity, Innate; D008928:Mitochondria / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D014777:Virus Diseases / Q000276:immunology* / Q000378:metabolism / Q000473:pathology