title: A broad-spectrum sunscreen prevents cumulative damage from repeated exposure to sub-erythemal solar ultraviolet radiation representative of temperate latitudes.
abstract: BACKGROUND
  We have previously shown the detrimental effects of 19 sub-erythemal exposures to daily ultraviolet radiation (DUVR, which mimics non-extreme exposure conditions), delivered over 4 weeks to volunteers. This source had UVA (320-400 nm) to UVB (290-320 nm) irradiance ratio of 25, instead of that close to 10 that is typically the case with solar-simulated radiation (SSR) that represents summer global sunlight with a clear sky and quasi-zenith solar irradiance.
  
  
  OBJECTIVE
  Here, we report on an extension of this previous study, in which we evaluated the photoprotection afforded by a broad-spectrum daily-care product with a low-sun protection factor (SPF 8, UVA-PF 7 and 3* rated UVA protection). We assessed cellular and molecular markers of photodamage that are relevant to skin cancer and photoageing.
  
  
  RESULTS
  This study shows that biological effects of repeated exposure to DUVR can be prevented by a broad-spectrum daily-care product and that the level of protection afforded varies with the studied endpoint.
  
  
  CONCLUSIONS
  Efficient daily UVR protection, as provided by a broad-spectrum daily-care product, is necessary to prevent the 'silent' sub-erythemal cumulative effects of UVR from inadvertent sun exposure.
authors.affiliation: La Roche-Posay Pharmaceutical Laboratories, Asnières, France. sseite@dca.loreal.com
authors.forename: S
authors.initials: S
authors.lastname: Seité
authors.forename: F
authors.initials: F
authors.lastname: Christiaens
authors.forename: C
authors.initials: C
authors.lastname: Bredoux
authors.forename: D
authors.initials: D
authors.lastname: Compan
authors.forename: H
authors.initials: H
authors.lastname: Zucchi
authors.forename: D
authors.initials: D
authors.lastname: Lombard
authors.forename: A
authors.initials: A
authors.lastname: Fourtanier
authors.forename: A R
authors.initials: AR
authors.lastname: Young
mesh_terms: D006801:Humans; D012871:Skin Diseases / Q000209:etiology / Q000517:prevention & control*; D013472:Sunlight / Q000009:adverse effects*; D013473:Sunscreening Agents
chemical_list: D013473:Sunscreening Agents