title: Enantio- and diastereoselective intermolecular Stetter reaction of glyoxamide and alkylidene ketoamides.
abstract: A triazolinylidene carbene catalyzed intermolecular Stetter reaction of glyoxamide and alkylidene ketoamides has been developed. 1,4-Dicarbonyl products are afforded in good to excellent yields, enantioselectivities, and diastereoselectivities. Further derivatization of the products affords useful intermediates for organic synthesis.
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.forename: Tomislav
authors.initials: T
authors.lastname: Rovis
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D013237:Stereoisomerism; D013453:Sulfonylurea Compounds / Q000737:chemistry*
chemical_list: D000577:Amides; D007659:Ketones; D013453:Sulfonylurea Compounds; C032160:glyoxamide