Tenosynovitis as a possible feature of immune reconstitution syndrome during highly active antiretroviral treatment (HAART).
An immune reconstitution syndrome (IRS) occurs in between 10% and 25% of patients starting highly active antiretroviral treatment (HAART). A 49-year-old patient presents a tenosynovitis 6 weeks after HAART initiation. In our patient, exhaustive tests for infectious, inflammatory and drug-related causes of tenosynovitis were negative. The improvement obtained with high-dose Non-steroidal anti-inflammatory-drug (NSAID) therapy and the patient's immunovirologic profile, supported a diagnosis of tenosynovitis associated with immune reconstitution, a form of IRS that has not previously been described. This original case increase the broad spectrum of inflammatory rheumatologic disorders associated with HIV infection.
Rivoisy
Claire
C
Service des Maladies Infectieuses et Tropicales, Hôpital Tenon, AP-HP, Paris, France.
Jauréguiberry
Stéphane
S
M'Bappe
Pauline
P
Gibeault
Matthieu
M
Bonnard
Philippe
P
Pialoux
Gilles
G
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005682:Gadolinium; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013717:Tenosynovitis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology*; D019562:Viral Load
D019380:Anti-HIV Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005682:Gadolinium; D007213:Indomethacin