title: Presumed corneal argyrosis from occlusive soft contact lenses: a case report.
abstract: OBJECTIVE
  To report a case of presumed corneal argyrosis associated with sliver nitrate-coated cosmetic soft contact lens wear.
  
  
  METHODS
  A 67-year-old woman wore silver nitrate-coated occlusive soft lenses for 17 years for the management of intractable diplopia. Slit-lamp examination revealed a diffuse blue-gray deposit that was characteristic of corneal argyrosis just anterior to Descemet membrane. Confocal microscopy, anterior segment optical coherence tomography, and noncontact specular microscopy were performed.
  
  
  RESULTS
  Confocal microscopy showed hyperreflective granules in Bowman layer, deep stroma, and Descemet membrane. The granules were below the resolution of anterior segment optical coherence tomography. Confocal and specular microscopy showed an abnormal reflection from the region of Descemet membrane. Central corneal endothelial cell density was 2560 cells per square millimeter.
  
  
  CONCLUSIONS
  Presumed corneal argyrosis can occur after long-term use of silver nitrate-coated contact lenses.
authors.affiliation: Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom. scott.hau@moorfields.nhs.uk
authors.forename: Scott C
authors.initials: SC
authors.lastname: Hau
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Tuft
mesh_terms: D000368:Aged; D001129:Argyria / Q000209:etiology* / Q000473:pathology; D020099:Coated Materials, Biocompatible / Q000009:adverse effects*; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology; D004172:Diplopia / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D018613:Microscopy, Confocal; D012835:Silver Nitrate / Q000009:adverse effects*
chemical_list: D020099:Coated Materials, Biocompatible; D012835:Silver Nitrate