Radiation health: mechanisms of radiation-induced cataracts in astronauts.
Dr. Blakely and colleagues have conducted a series of experiments to explain the molecular basis by which space radiation causes cataracts, particularly with regard to elucidating how space radiation alters gene expression profiles in the process of lens cell differentiation. To do this, they "developed an in vitro model of differentiating human lens epithelial cells...that mimicked the normal growth environment in the tissue" (2). They have shown that radiation, especially high-LET (linear energy transfer) iron ion radiation, affects gene and protein expression of many cells involved in lens cell differentiation and cell cycle regulation. They have also developed a schematic model to explain the action of ionizing radiation on specific molecules leading to perturbations in cell cycle regulation and ultimately affecting lens cell differentiation. These results can provide a basis for developing countermeasures to protect astronauts in long-duration spaceflight and for improving risk assessments of space-radiation-caused cataracts. This research can also benefit individuals on Earth who are exposed to clinical and occupational radiation.
Frey
Mary Anne
MA
D018480:Astronauts; D002386:Cataract / Q000503:physiopathology*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D007908:Lens, Crystalline / Q000503:physiopathology / Q000528:radiation effects*; D020782:Matrix Metalloproteinases / Q000378:metabolism; D013026:Space Flight
D050759:Cyclin-Dependent Kinase Inhibitor p21; D020782:Matrix Metalloproteinases