title: Trabecular bone analysis in CT and X-ray images of the proximal femur for the assessment of local bone quality.
abstract: Currently, conventional X-ray and CT images as well as invasive methods performed during the surgical intervention are used to judge the local quality of a fractured proximal femur. However, these approaches are either dependent on the surgeon's experience or cannot assist diagnostic and planning tasks preoperatively. Therefore, in this work a method for the individual analysis of local bone quality in the proximal femur based on model-based analysis of CT- and X-ray images of femur specimen will be proposed. A combined representation of shape and spatial intensity distribution of an object and different statistical approaches for dimensionality reduction are used to create a statistical appearance model in order to assess the local bone quality in CT and X-ray images. The developed algorithms are tested and evaluated on 28 femur specimen. It will be shown that the tools and algorithms presented herein are highly adequate to automatically and objectively predict bone mineral density values as well as a biomechanical parameter of the bone that can be measured intraoperatively.
authors.affiliation: Department of Medical Image Analysis, Universityfor Health Sciences, Medical Informatics and Technology, 6060 Hall in Tirol, Austria. karl.fritscher@umit.at
authors.forename: Karl
authors.initials: K
authors.lastname: Fritscher
authors.forename: Agnes
authors.initials: A
authors.lastname: Grunerbl
authors.forename: Markus
authors.initials: M
authors.lastname: Hanni
authors.forename: Norbert
authors.initials: N
authors.lastname: Suhm
authors.forename: Clemens
authors.initials: C
authors.lastname: Hengg
authors.forename: Rainer
authors.initials: R
authors.lastname: Schubert
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005264:Femoral Fractures / Q000473:pathology; D005269:Femur / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008954:Models, Biological; D015233:Models, Statistical; D025341:Principal Component Analysis; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods*; D019415:Torque