Oxidative stress-mediated myocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats.
In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were administered to the rats for 1 week. Serum biochemical cardiotoxicity parameters and tissue malondialdehyde and nitric oxide levels were measured. All measured parameters were found elevated in the drug-treated rats, being the highest in the 50-mg/kg ofloxacin-treated rats. Ciprofloxacin and ofloxacin may cause myocardiotoxicity by inducing the oxidative stress in the heart, and nitric oxide is partly responsible for this toxicity.
Saraçoğlu
Ahmet
A
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Eskişehir, Turkey. ahsaracoglu@anadolu.edu.tr
Temel
Halide E
HE
Ergun
Bülent
B
Colak
Omer
O
D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D015415:Biomarkers / Q000097:blood; D002939:Ciprofloxacin / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced* / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D015242:Ofloxacin / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000890:Anti-Infective Agents; D015415:Biomarkers; D009569:Nitric Oxide; D008315:Malondialdehyde; D002939:Ciprofloxacin; D015242:Ofloxacin