title: Haemophilia A (factor VIII deficiency) in a litter of Weimaraners.
abstract: Inherited coagulopathies are reported in a number of dog breeds. However, to date, there is no report of Weimaraners suffering factor VIII deficiency (haemophilia A). We report the discovery of haemophilia A in both males from a single litter of Weimaraners. Haemophilia A in human beings often results from a de novo stochastic mutation. We found no evidence using currently available screening tests of haemophilia A in relatives as far back as three generations making a stochastic mutation possible in this litter.
authors.affiliation: Department of Veterinary Medicine, University ofCambridge, Madingley Road, Cambridge CB3 0ES, UK.
authors.forename: M D
authors.initials: MD
authors.lastname: Dunning
authors.forename: G F
authors.initials: GF
authors.lastname: Averis
authors.forename: H
authors.initials: H
authors.lastname: Pattinson
authors.forename: M
authors.initials: M
authors.lastname: Targett
authors.forename: S
authors.initials: S
authors.lastname: Cade
authors.forename: M E
authors.initials: ME
authors.lastname: Herrtage
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005169:Factor VIII / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006467:Hemophilia A / Q000235:genetics / Q000662:veterinary*; D008297:Male; D009154:Mutation; D010375:Pedigree
chemical_list: D005169:Factor VIII