Granulocyte transfusions for pediatric patients and the establishment of national treatment guidelines and donor registry.
G-CSF/dexamethasone stimulated donor derived granulocyte transfusion (GTX) has been shown in non-randomized studies to be a useful co-therapy in immune-compromised patients unresponsive to conventional antimicrobial treatments. Reports of GTX are however usually single institution adult experiences. Substantiated pediatric data, other than in neonates, is less common.
Vrielink
H
H
Sanquin Blood Bank North West, Plesmalaan 125, 1066 CX Amsterdam, The Netherlands. h.vrielink@sanquin.nl
Meijer
B
B
van't Ende
E
E
Ball
L M
LM
Brand
A
A
Zwaginga
J J
JJ
D000328:Adult; D002648:Child; D006098:Granulocytes / Q000637:transplantation*; D006801:Humans; D016867:Immunocompromised Host / Q000502:physiology; D007231:Infant, Newborn; D007258:Informed Consent; D009426:Netherlands; D009503:Neutropenia / Q000628:therapy; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D012042:Registries