title: The complexon-renal stone interaction: solubility and electronic microscopy studies.
abstract: We have studied how complex formation between calcium and ethylenediaminetetraacetate or citrate ions influences the surface texture and the size of passed oxalate-phosphate renal stones. The four hour concrement treatment by sodium citrate or ethylenediaminetetraacetate aqueous solutions strongly affects the stone texture and provides a mass loss of 6-15%. We have found a significant decrease of the calcium and phosphor content on a concrement surface and formation of appreciable cracks. Our results do indicate that the Ca-complexon interaction can be effectively applied for disrupting some types of renal stones and, especially, residual concrements, which frequently occurs after a surgical operation or an extracorporeal shock-wave lithotripsy. This study provides an additional quantitative physicochemical basis for this slightly invasive therapy.
authors.affiliation: Institute of Solution Chemistry of Russian Academy of Sciences, Ivanovo, Russian Federation. kustov@isuct.ru
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Kustov
authors.forename: Boris D
authors.initials: BD
authors.lastname: Berezin
authors.forename: Vyacheslav N
authors.initials: VN
authors.lastname: Trostin