title: 3-Hydroxy-2-phenyl-4(1H)-quinolinones as promising biologically active compounds.
abstract: 2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.
authors.affiliation: Department of Organic Chemistry, Palacký University, Tr. Svobody 8, 771 46 Olomouc, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Hradil
authors.forename: J
authors.initials: J
authors.lastname: Hlavác
authors.forename: M
authors.initials: M
authors.lastname: Soural
authors.forename: M
authors.initials: M
authors.lastname: Hajdúch
authors.forename: M
authors.initials: M
authors.lastname: Kolár
authors.forename: R
authors.initials: R
authors.lastname: Vecerová
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D015363:Quinolones