title: Influence of menopausal status on sleep and hot flashes throughout breast cancer adjuvant chemotherapy.
abstract: OBJECTIVE
  To examine the patterns and differences among sleep and hot flashes based on menopausal status (pre, peri, or post) in breast cancer adjuvant chemotherapy patients before, during, and after treatment.
  
  
  METHODS
  Secondary analysis from a randomized clinical trial.
  
  
  METHODS
  Outpatient clinics and participants' homes.
  
  
  METHODS
  Two hundred nineteen (219) women; mean age of 52 years (29-79); postoperative, Stages I to IIIA breast cancer.
  
  
  METHODS
  Participants were randomized to a behavioral sleep intervention or a healthy eating control group. Variables measured were menopausal status (self-report), subjective sleep (Pittsburgh Sleep Quality Index), objective sleep (actigraphy), perceived interruption of sleep by hot flashes (diary), and demographic/medical characteristics. Data reported were collected 48 hours before initial chemotherapy, at treatment 4, and 30 days after the last treatment. Analysis included descriptives and repeated measures mixed model analysis of variance.
  
  
  RESULTS
  Objective sleep and the perceived interruption of sleep by hot flashes changed significantly over time. Sleep and hot flashes differed over time by menopausal status. Only hot flashes were significantly different by study group and by menopausal status over time.
  
  
  CONCLUSIONS
  Women's menopausal status when starting chemotherapy was associated with differing patterns of sleep and hot flashes over time.
authors.affiliation: University of Nebraska Medical Center, Omaha, NE 68198-5330, USA. aberger@unmc.edu
authors.forename: Ann M
authors.initials: AM
authors.lastname: Berger
authors.forename: Heather A
authors.initials: HA
authors.lastname: Treat Marunda
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Agrawal
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D019584:Hot Flashes / Q000150:complications*; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D012893:Sleep Wake Disorders / Q000150:complications* / Q000175:diagnosis