title: The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease.
abstract: We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0-32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ-39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales.
authors.affiliation: Università Federico II and IDC-Hermitage-Capodimonte, Napoli, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Barone
authors.forename: Angelo
authors.initials: A
authors.lastname: Antonini
authors.forename: Carlo
authors.initials: C
authors.lastname: Colosimo
authors.forename: Roberto
authors.initials: R
authors.lastname: Marconi
authors.forename: Letterio
authors.initials: L
authors.lastname: Morgante
authors.forename: Tania P
authors.initials: TP
authors.lastname: Avarello
authors.forename: Eugenio
authors.initials: E
authors.lastname: Bottacchi
authors.forename: Antonino
authors.initials: A
authors.lastname: Cannas
authors.forename: Gabriella
authors.initials: G
authors.lastname: Ceravolo
authors.forename: Roberto
authors.initials: R
authors.lastname: Ceravolo
authors.forename: Giulio
authors.initials: G
authors.lastname: Cicarelli
authors.forename: Roberto M
authors.initials: RM
authors.lastname: Gaglio
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Giglia
authors.forename: Francesco
authors.initials: F
authors.lastname: Iemolo
authors.forename: Michela
authors.initials: M
authors.lastname: Manfredi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Meco
authors.forename: Alessandra
authors.initials: A
authors.lastname: Nicoletti
authors.forename: Massimo
authors.initials: M
authors.lastname: Pederzoli
authors.forename: Alfredo
authors.initials: A
authors.lastname: Petrone
authors.forename: Antonio
authors.initials: A
authors.lastname: Pisani
authors.forename: Francesco E
authors.initials: FE
authors.lastname: Pontieri
authors.forename: Rocco
authors.initials: R
authors.lastname: Quatrale
authors.forename: Silvia
authors.initials: S
authors.lastname: Ramat
authors.forename: Rosanna
authors.initials: R
authors.lastname: Scala
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Volpe
authors.forename: Salvatore
authors.initials: S
authors.lastname: Zappulla
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Bentivoglio
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Stocchi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Trianni
authors.forename: Paolo Del
authors.initials: PD
authors.lastname: Dotto
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001007:Anxiety / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D003863:Depression / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D005221:Fatigue / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D005260:Female; D005767:Gastrointestinal Diseases / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D010146:Pain / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D011788:Quality of Life; D020919:Sleep Disorders, Intrinsic / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D014555:Urination Disorders / Q000453:epidemiology / Q000209:etiology / Q000523:psychology
chemical_list: D000978:Antiparkinson Agents