Preoperative radiochemotherapy in the treatment of advanced oral cancer: outcome of 276 patients.
BACKGROUND
The aim of this study was to review survival and locoregional control in patients with advanced oral and oropharyngeal squamous cell carcinoma treated by multimodal therapy with preoperative radiochemotherapy and radical surgery.


METHODS
Retrospective cohort study.


METHODS
Included in this analysis are 276 consecutive patients with UICC disease stages III and IV (T2: 13.0%; T3: 16.7%; T4: 70.3%; N0: 29.7%; N1: 20.3%; N2: 45.3%; N3: 4.7%; stage III: 16.3%; stage IV: 83.7%). All patients received preoperative radiochemotherapy (50Gy, Mitomycin and 5-Fluorouracil) and radical locoregional resection.


RESULTS
Median surveillance period was 101.4 months (24-202 months). 5-year overall survival probability was 53.9%. 5-year local control probability was 70.2%.


CONCLUSIONS
These results underline the reliability of preoperative treatment of patients with oral and oropharyngeal cancer.
Klug
Clemens
C
Hospital of Cranio-Maxillofacial and Oral Surgery, Department of Basic Psychological Research, School of Psychology, Medical University of Vienna, Vienna 1090, Austria. clemens.klug@meduniwien.ac.at
Berzaczy
Dominik
D
Voracek
Martin
M
Nell
Christina
C
Ploder
Oliver
O
Millesi
Werner
W
Ewers
Rolf
R
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D015331:Cohort Studies; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D011300:Preoperative Care; D012189:Retrospective Studies; D016896:Treatment Outcome
D016685:Mitomycin; D005472:Fluorouracil