title: [Prognostic factors for survival in patients with transitional bladder cancer treated with radical cystectomy].
abstract: OBJECTIVE
  To recognize clinical and pathological variables that influence in bladder cancer specific mortality in patients with transitional bladder cancer treated with radical cystectomy.
  
  
  METHODS
  Retrospective analysis of 333 patients with transitional bladder cancer treated with radical cystectomy. Variables included during pre-cystectomy, peri-cystectomy and post-cystectomy period were analyzed. Four groups were defined based on pathological state: a) Organ-confine bladder cancer without lymph node metastasis (pT0-2, pN0); b) Extravesical desease without lymph node metastasis (pT3-4, pN0); c) Bladder cancer with lymph node metastasis (pT0-4, pN+); d) No data of lymph node affection (pT0-4, pNx). Univariate analysis and two models of multivariate analysis were performed including the risk group as a variable in one the latest.
  
  
  RESULTS
  Mean follow up was 52.6 +/- 51 (2-221) months with a median of 31 months. Pathological state pT0 was observed in 7.2% of the patients, 12% were pT1, 26.7% pT2, 34.5% pT3 and 10.5% pT4. Lymph node metastasis was detected in 20.7% of the patients. Lymph node metastasis increased according to pathological state rises. Five and 10 years specific survival was 57% and 54% respectively.
  
  
  CONCLUSIONS
  Local pathological state, lymph node status and risk groups were independent predictive factors for bladder cancer specific survival. Risk group association is a reliable method to predict bladder cancer specific survival and to identify the suitable patient group to get benefit from adjuvant therapy.
authors.affiliation: Hospital General Universitario Gregorio Marañón, Madrid, España. juanimonzo@hotmail.com
authors.forename: Juan I
authors.initials: JI
authors.lastname: Monzó Gardiner
authors.forename: Felipe
authors.initials: F
authors.lastname: Herranz Amo
authors.forename: José M
authors.initials: JM
authors.lastname: Díez Cordero
authors.forename: Ramiro
authors.initials: R
authors.lastname: Cabello Benavente
authors.forename: Angel
authors.initials: A
authors.lastname: Silmi Moyano
authors.forename: Carlos
authors.initials: C
authors.lastname: Hernández Fernández
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000401:mortality* / Q000601:surgery*; D015653:Cystectomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000401:mortality* / Q000601:surgery*