title: On the biomechanics of heart valve function.
abstract: Heart valves (HVs) are fluidic control components of the heart that ensure unidirectional blood flow during the cardiac cycle. However, this description does not adequately describe the biomechanical ramifications of their function in that their mechanics are multi-modal. Moreover, they must replicate their cyclic function over an entire lifetime, with an estimated total functional demand of least 3x10(9) cycles. The focus of the present review is on the functional biomechanics of heart valves. Thus, the focus of the present review is on functional biomechanics, referring primarily to biosolid as well as several key biofluid mechanical aspects underlying heart valve physiological function. Specifically, we refer to the mechanical behaviors of the extracellular matrix structural proteins, underlying cellular function, and their integrated relation to the major aspects of valvular hemodynamic function. While we focus on the work from the author's laboratories, relevant works of other investigators have been included whenever appropriate. We conclude with a summary of important future trends.
authors.affiliation: Department of Bioengineering, Engineered Tissue Mechanics and Mechanobiology Laboratory, The McGowan Institute, University of Pittsburgh, Pittsburgh, PA, United States. msacks@pitt.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Sacks
authors.forename: W
authors.initials: W
authors.lastname: David Merryman
authors.forename: David E
authors.initials: DE
authors.lastname: Schmidt
mesh_terms: D001696:Biomechanical Phenomena / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006351:Heart Valves / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans
chemical_list: D016326:Extracellular Matrix Proteins