Heart rate variability in rats with experimental chronic heart failure and long-term exposure to beta-adrenoblockers.
Simulation of chronic heart failure in rats led to an increase in heart rate variability and decrease in heart rate. All beta-blockers also promoted the heart rate variability augmentation in ill animals. The most potent effects on heart rate variability were produced by pindolol, atenolol, and propranolol. Bisoprolol and metoprolol affected heart rate and heart rate variability in less extent, and nebivolol normalized a part of heart rate variability parameters.
Sal'nikov
E V
EV
Department of Biology, Yaroslavl State Medical Academy, Russia. sal'nikov@hist.yma.ac.ru
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D001578:Benzopyrans / Q000494:pharmacology; D017298:Bisoprolol / Q000494:pharmacology; D004983:Ethanolamines / Q000494:pharmacology; D006333:Heart Failure / Q000188:drug therapy; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D000068577:Nebivolol; D010869:Pindolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol; D001262:Atenolol; D011433:Propranolol; D010869:Pindolol; D008790:Metoprolol; D017298:Bisoprolol