[The role of changes of matrix metalloproteinase in cardiovascular diseases].
The review summarizes information about changes of extracellular matrix (ECM) in cardiovascular diseases. Special attention is paid to different groups of extra cellular matrix proteins (collagen I and III type, fibronectine) in the development of cardiac fibrosis in chronic heart failure. The role of matrix metalloproteinases in degradation of components of ECM is analyzed. Interrelationship between matrix metalloproteinases and their tissue inhibitors in fibrosis and cardiac structural chances is analyzed.
Gasanov
A G
AG
Bershova
T V
TV
D000818:Animals; D002908:Chronic Disease; D024042:Collagen Type I / Q000378:metabolism*; D024061:Collagen Type III / Q000378:metabolism*; D005109:Extracellular Matrix / Q000201:enzymology*; D005355:Fibrosis / Q000208:ethnology / Q000473:pathology; D006333:Heart Failure / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology
D024042:Collagen Type I; D024061:Collagen Type III; D020782:Matrix Metalloproteinases