title: Synthesis, characterization and antimicrobial activity of 3d transition metal complexes of a biambidentate ligand containing quinoxaline moiety.
abstract: A new series of oxovanadium(IV), chromium(III), manganese(II), iron(III), cobalt(II), nickel(II), and copper(II) complexes of the 3-hydrazino quinoxaline-2-one (HQO) were prepared and characterized. The ligand exhibits biambidenticity. It behaves as a bidentate ON donor in oxovanadium(IV), iron(III) and copper(II) complexes and as a bis bidentate ONNN donor in chromium(III), manganese(II), cobalt(II) and nickel(II) complexes. The nature of bonding and the stereochemistry of the complexes have been deduced from elemental analyses, thermal, infrared, (1)H NMR, electronic spectra, magnetic susceptibility and conductivity measurements. An octahedral geometry was suggested for all the complexes. All the complexes show subnormal magnetic moments. The ligand, HQO, and its complexes were tested against one strain Gram +ve bacteria (Staphylococcus aureus), Gram -ve bacteria (Escherichia coli). The prepared metal complexes exhibited higher antimicrobial activities than the parent ligand.
authors.affiliation: Department of Chemistry, University College for Women, Osmania University, Koti, Hyderabad, Andhra Pradesh, 500095, India. ananthaprasad2003@yahoo.co.in
authors.forename: P V
authors.initials: PV
authors.lastname: Anantha Lakshmi
authors.forename: P Saritha
authors.initials: PS
authors.lastname: Reddy
authors.forename: V Jayatyaga
authors.initials: VJ
authors.lastname: Raju
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002857:Chromium / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects / Q000502:physiology; D007501:Iron / Q000737:chemistry; D008024:Ligands; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D008345:Manganese / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology; D014638:Vanadates / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D008024:Ligands; D046911:Macromolecular Substances; D008670:Metals; D011810:Quinoxalines; D002857:Chromium; C075743:oxovanadium IV; D003035:Cobalt; D014638:Vanadates; D008345:Manganese; D003300:Copper; D009532:Nickel; D007501:Iron