Changes in the rhythmoinotropic dependence of the myocardium in rats with postinfarction cardiosclerosis after beta1-adrenoreceptor blocking.
The rhythmoinotropic dependence of the papillary muscles was studied in rats with postinfarction cardiosclerosis after blocking of beta(1)-adrenoreceptors by concor (7 mg/kg daily). The development of postinfarction cardiosclerosis led to a reduction of the postextrasystolic potentiation and of potentiation induced by periods of rest. Preliminary blocking of beta(1)-adrenoreceptors stimulated the postextrasystolic contractions and contractions after periods of rest in the myocardium of rats with postinfarction cardiosclerosis. These results suggest that blocking of beta(1)-adrenoreceptors promotes an improvement of calcium-accumulating function of the cardiomyocyte sarcoplasmatic reticulum in the myocardium of rats with postinfarction cardiosclerosis.
Kondratyeva
D S
DS
Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia. dina@cardio.tsu.ru
Afanasyev
S A
SA
Ligacheva
N A
NA
Popov
S V
SV
Krivolapov
S N
SN
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D017298:Bisoprolol / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D006352:Heart Ventricles / Q000473:pathology; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D010210:Papillary Muscles / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D002118:Calcium; D017298:Bisoprolol