Involvement of interstitial structures of the kidney into hydrosmotic effect of vasopressin (morphofunctional study).
Administration of desmopressin for 4 days to homozygous Brattleboro rats lacking endogenous vasopressin induced an increase in osmotic concentration and was accompanied by typical changes in the morphofunctional state of interstitial cells of the renal papilla. These changes increase the permeability of extracellular matrix, which attested to the involvement of interstitial cells into hydrosmotic reaction to vasopressin.
Shestopalova
L V
LV
Department of Physiology, Novosibirsk State University, Russia.
Lavrinenko
V A
VA
Shkurupiy
V A
VA
Ivanova
L N
LN
D000818:Animals; D050034:Antidiuretic Agents / Q000494:pharmacology*; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000648:ultrastructure*; D007679:Kidney Medulla / Q000187:drug effects / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D051381:Rats; D011910:Rats, Brattleboro; D014667:Vasopressins / Q000378:metabolism
D050034:Antidiuretic Agents; D014667:Vasopressins; D003894:Deamino Arginine Vasopressin