Serum adenosine deaminase activity in gestational diabetes mellitus and normal pregnancy.
OBJECTIVE
To our knowledge, there is no report regarding adenosine deaminase activity (ADA) in gestational diabetes mellitus (GDM). The aim of the present study was to investigate the level of serum ADA activity in normal pregnancy, GDM and normal non-pregnant women.


METHODS
The serum catalytic concentration of ADA was measured in samples of 20 GDM, 40 normal pregnant and 20 non-pregnant healthy women.


RESULTS
Adenosine deaminase activity was significantly higher in GDM (24.30 +/- 8.04 IU/L) and pregnant women (23.88 +/- 8.66 IU/L) than those of normal non-pregnant individuals (11.85 +/- 3.23 IU/L) (P < 0.0001), but the ADA level was not significantly different from GDM and normal pregnant women (P = 0.97).


CONCLUSIONS
Adenosine deaminase activity was significantly higher in GDM and pregnant individuals than normal group in this study. Previous reports in this field are contentious; therefore, ADA activity could be regulated in different population by immunologic and genetic factors.
Mokhtari
Mojgan
M
Department of Obstetrics and Gynaecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Hashemi
Mohammad
M
Yaghmaei
Minoo
M
Molashahi
Fariba
F
Shikhzadeh
Abdolsamad
A
Niazi
Abbasali
A
Ghavami
Saeid
S
D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000201:enzymology*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D055815:Young Adult
D000243:Adenosine Deaminase