Acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto's thyroiditis.
We describe a case of acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto's thyroiditis. In Hashimoto's thyroiditis, the leukocyte function-associated antigen-1 (LFA-1)/intercellular vascular cell adhesion molecule-1 (ICAM-1) and very late antigen-4 (VLA-4)/vascular cell adhesion molecule-1 (VCAM-1) pathways in T lymphocytes and the vascular endothelium both play a role in the initiation and enhancement of lymphocyte recruitment to the thyroid glands during an autoimmune attack. The leukemic blast cells were positive for VLA-4 and negative for LFA-1 by immunohistochemistry. The presence of VLA-4 in blast cells might play a key role in the migration of blast cells to the thyroid glands.
Nakayama
Shoko
S
Department of Internal Medicine (I), Osaka Medical College, Takatsuki City, Osaka, 569-0801, Japan. in1304@poh.osaka-med.ac.jp
Yokote
Taiji
T
Kobayashi
Kichinosuke
K
Hirata
Yuji
Y
Hiraiwa
Tetsuya
T
Akioka
Toshikazu
T
Miyoshi
Takuji
T
Takubo
Takayuki
T
Tsuji
Motomu
M
Hanafusa
Toshiaki
T
D000368:Aged; D017809:Fatal Outcome; D005260:Female; D050031:Hashimoto Disease / Q000150:complications* / Q000378:metabolism; D006801:Humans; D039041:Integrin alpha4beta1 / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D017254:Leukemic Infiltration; D011877:Radionuclide Imaging; D013961:Thyroid Gland / Q000473:pathology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
D039041:Integrin alpha4beta1; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1