title: The first clinical case due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus and a field survey.
abstract: BACKGROUND
  Crimean-Congo Hemorrhagic Fever (CCHF) is a fatal infection, but no clinical case due to AP92 strain was reported. We described the first clinical case due to AP92 like CCHFV.
  
  
  METHODS
  A case infected by a AP92 like CCHFV was detected in Balkanian part of Turkey. Diagnosis was confirmed by RT-PCR and sequencing. A human serologic and tick survey studies were performed in the region, where the case detected.
  
  
  RESULTS
  Thirty eight individuals out of 741 were found to be anti CCHFV IgM positive. The attack rate for overall CCHFV was calculated as 5.2%. In univariate analyses, CCHFV IgM positivity was found to be associated with the age (p < 0.001), male gender (p = 0.001), agricultural activity (p = 0.036), and history of tick bite (p = 0.014). In multivariate analysis, older age (OR: 1.03, CI:1.01-1.05, p < 0.001), male gender were found to be the risk factors (OR: 2.5, CI:1.15-5.63, p = 0.020) for CCHFV infection.
  
  
  CONCLUSIONS
  This is the first human case with AP92 like CCHFV infection. Furthermore, this is the first report of AP92 like strain in Turkey. In the region, elderly males carry the highest risk for CCHFV infection.
authors.affiliation: Microbiology and Clinical Microbiology Department, Istanbul University, Cerrahpaşa Medical Faculty, Istanbul, Turkey. kmidilli@gmail.com
authors.forename: Kenan
authors.initials: K
authors.lastname: Midilli
authors.forename: Ayşen
authors.initials: A
authors.lastname: Gargili
authors.forename: Onder
authors.initials: O
authors.lastname: Ergonul
authors.forename: Murat
authors.initials: M
authors.lastname: Elevli
authors.forename: Sevgi
authors.initials: S
authors.lastname: Ergin
authors.forename: Nesrin
authors.initials: N
authors.lastname: Turan
authors.forename: Gönül
authors.initials: G
authors.lastname: Sengöz
authors.forename: Recep
authors.initials: R
authors.lastname: Ozturk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bakar
mesh_terms: D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D005260:Female; D005838:Genotype; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000235:genetics / Q000302:isolation & purification*; D006479:Hemorrhagic Fever, Crimean / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012367:RNA, Viral / Q000032:analysis; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D014421:Turkey / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M; D012367:RNA, Viral