Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes.
We found alpha-glucosidase inhibitory (alpha-GI) effect of metal ions and their complexes which showed the high blood glucose lowering effect in diabetic model animals. The Cu(II) ion and its complexes showed strong alpha-GI activity greater than clinically used acarbose in in vitro studies. Furthermore, in in vivo experiments, alpha-GI action was newly discovered in normal ddy mice. These results suggested that one of action mechanisms of the anti-diabetic metal ions and complexes is related to the alpha-GI effects.
Yoshikawa
Yutaka
Y
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. yutaka@mb.kyoto-phu.ac.jp
Hirata
Ryoko
R
Yasui
Hiroyuki
H
Sakurai
Hiromu
H
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003300:Copper / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000494:pharmacology*
D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D009942:Organometallic Compounds; D003300:Copper