title: Target-selective degradation of cancer-related proteins by novel photosensitizers for molecular-targeted photodynamic therapy.
abstract: Proteins are key players in many biological events including cancers. The development of novel photosensitizers for the selective degradation of cancer-related proteins has attracted much attention in the fields of photodynamic therapy for various cancers. In this review article, several novel photosensitizers, which selectively degrade cancer-related proteins under photoirradiation and mild conditions without any further additives, are introduced. This novel class of photosensitizers promises bright prospects for finding molecular-targeted drugs for cancer photodynamic therapy in the near future.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Kohoku-ku Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Toshima
authors.forename: Shuho
authors.initials: S
authors.lastname: Tanimoto
authors.forename: Kana
authors.initials: K
authors.lastname: Tsumura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umezawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D006801:Humans; D008027:Light; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*
chemical_list: D009363:Neoplasm Proteins; D017319:Photosensitizing Agents