title: Divergent and expeditious access to fused skeletons inspired by indole alkaloids and transtaganolides.
abstract: We report the development of a divergent synthetic process entailing four-step access to the elaborate fused skeletons reminiscent of aspidophytines and transtaganolides. A variety of branched precursors were synthesized on the basis of Ugi condensations and installation of diazoimide and subjected to rhodium-catalyzed tandem reactions. Switching of cyclization modes was demonstrated by the choice of the amine building blocks installed at site C.
authors.affiliation: Division of Chemistry, Graduate School of Science, Hokkaido University, N21, W10, Sapporo 001-0021, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Mizoguchi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Oguri
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tsuge
authors.forename: Hideaki
authors.initials: H
authors.lastname: Oikawa
mesh_terms: D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry
chemical_list: D037621:Artemisinins; D026121:Indole Alkaloids; D012238:Rhodium