MicroRNAs and immune regulatory T cells.
MicroRNAs (miRNAs)-mediated RNA interference are emerging as an important regulatory pathway for various biological processes, including development, differentiation, and homeostasis. Accumulated evidence suggests that miRNAs regulate T cell and B cell differentiation, proliferation, and apoptosis. Deletion of miRNAs in hematopoietic stem cells or in thymus disrupts T cell homeostasis and results in autoimmunity and abnormal cytokine production. Regulatory T cells are potent immune regulators. In this mini-review, we provide a brief overview of the important roles of miRNAs in the development and function of T cells, especially in immune regulatory T cells.
Zhou
Li
L
Henry Ford Hospital Immunology Program, Henry Ford Hospital, Detroit, MI, USA.
Seo
Kook Heon
KH
Wong
Henry K
HK
Mi
Qing-Sheng
QS
D000818:Animals; D017209:Apoptosis; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D049109:Cell Proliferation; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D035683:MicroRNAs / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
D016207:Cytokines; D035683:MicroRNAs