[The role of thyroid hypofunction in development of metabolic syndrome].
OBJECTIVE
To study the role of hypothyroidism and concomitant obesity in the development of metabolic syndrome (MS).


METHODS
We examined 60 women suffering from obesity and hypothyroidism (TTH 22.24 +/- 4.031). We studied lipid spectrum, carbohydrate metabolism, BP and insulin resistance, fat tissue distribution, exercise tolerance.


RESULTS
According to IDF (2005) criteria the women had: metabolic syndrome (83.4%), newly diagnosed hypothyroidism (95%), decompensated hypothyroidism (90%), subclinical hypothyroidism (65%) after six-month replacement therapy with L-T4 MS symptoms declined.


CONCLUSIONS
Abnormally high level of TSH may be a component of metabolic syndrome.
Demidova
T Iu
TIu
Galieva
O R
OR
D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D050152:Intra-Abdominal Fat; D050356:Lipid Metabolism / Q000187:drug effects; D024821:Metabolic Syndrome / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use
D013974:Thyroxine