Lipid peroxidation in the liver of mice during development of granulomatous inflammation after combined infection with C. albicans and M. tuberculosis.
Activity of LPO in the liver of CBA mice during the development of granulomatous inflammation after combined infection with C. albicans and M. tuberculosis was evaluated by the levels of conjugated dienes, ketodienes, conjugated trienes, and products of interactions between intermediate LPO products and 2-TBA. The content of primary and secondary LPO products peaked on days 3 and 10 after infection by C. albicans, respectively. After M. tuberculosis infection, the maximum accumulation of TBA-active LPO products in the liver was noted on day 3, while the level of primary lipid peroxides virtually did not increase. The dynamics of primary and secondary LPO products in the liver during granulomatous inflammation development was similar to that during infection of mice with C. albicans alone. Hence, the development of granulomatous inflammation induced by C. albicans or M. tuberculosis or both these agents, was associated with increased LPO activity in the liver. The dynamics of primary and secondary LPO products depended on the infectious agent or combination of agents.
Makarova
O P
OP
Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. opmak@soramn.ru
Tsyrendorjiev
D D
DD
Shkurupiy
V A
VA
D000818:Animals; D002176:Candida albicans / Q000502:physiology*; D002177:Candidiasis / Q000503:physiopathology*; D006099:Granuloma / Q000276:immunology* / Q000473:pathology; D007249:Inflammation / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008099:Liver / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000502:physiology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors; D014376:Tuberculosis / Q000503:physiopathology*
D017392:Thiobarbituric Acid Reactive Substances