title: First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy.
abstract: The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.
authors.affiliation: Université de Toulouse, UPS, Centre de Recherche Cerveau et Cognition, Toulouse, France. raph.serduc@gmail.com
authors.forename: Raphaël
authors.initials: R
authors.lastname: Serduc
authors.forename: Elke
authors.initials: E
authors.lastname: Bräuer-Krisch
authors.forename: Audrey
authors.initials: A
authors.lastname: Bouchet
authors.forename: Luc
authors.initials: L
authors.lastname: Renaud
authors.forename: Thierry
authors.initials: T
authors.lastname: Brochard
authors.forename: Alberto
authors.initials: A
authors.lastname: Bravin
authors.forename: Jean Albert
authors.initials: JA
authors.lastname: Laissue
authors.forename: Géraldine
authors.initials: G
authors.lastname: Le Duc
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000532:radiotherapy*; D018316:Gliosarcoma / Q000532:radiotherapy*; D008297:Male; D011879:Radiotherapy Dosage; D051381:Rats; D011916:Rats, Inbred F344; D017356:Synchrotrons