Nitroxyl (HNO) signaling.
Nitroxyl (HNO) has become a nitrogen oxide of significant interest due to its reported biological activity. The actions of HNO in the cardiovascular system appear to make it a good candidate for therapeutic applications for cardiovascular disorders and other potentially important effects have been noted as well. Although the chemistry associated with this activity has not been firmly established, the propensity for HNO to react with thiols and metals are likely mechanisms. Herein, are described the biological activity of HNO and some of the chemistry of HNO that may be responsible for its biological effects.
Fukuto
Jon M
JM
Department of Chemistry, Sonoma State University, Rohnert Park, CA 94928, USA. jon.fukuto@sonoma.edu
Bianco
Christopher L
CL
Chavez
Tyler A
TA
D000818:Animals; D006801:Humans; D009589:Nitrogen Oxides / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D009589:Nitrogen Oxides; C039900:nitroxyl