title: Dynamic contrast-enhanced magnetic resonance imaging in the evaluation of the prostate.
abstract: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a novel MR technique that allows to interrogate pharmacokinetic processes in the tissues at a voxel level and to generate parametric maps that can be displayed for clinical interpretation. Dynamic contrast-enhanced MRI is an important imaging technique for the imaging of angiogenesis and vasculogenesis because it probes the microvascular networks at a microscopic level by being sensitive to the compartmentalization of tissue into the vascular and extravascular-extracellular space and to the diffusion of contrast molecules across the vascular endothelium and capillary boundaries. Dynamic contrast-enhanced MRI has already shown to improve detection and localization of prostate cancer, to improve prediction of extracapsular extension, determination of tumor volume, and after treatment follow-up. In this article, we outline the fundamental principles of DCE-MRI and describe the application of DCE methods in the imaging of the prostate.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21287-0750, USA.
authors.forename: David
authors.initials: D
authors.lastname: Bonekamp
authors.forename: Katarzyna J
authors.initials: KJ
authors.lastname: Macura
mesh_terms: D003287:Contrast Media / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008433:Mathematics; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA