title: Has imiquimod 5% cream a role in the management of recurrent basal cell carcinoma?
abstract: Basal cell carcinoma (BCC) is a cutaneous malignancy with a tendency to spread locally and with several clinical and histological subsets. We studied 34 patients with a clinical diagnosis of recurrent BCC on different anatomical locations, to whom imiquimod 5% cream was administered on a low-frequency regime (3 times a week for 6 weeks), with a minimum of 3 years follow-up after completion of treatment. Clinical clearance rate at 1, 2 and 3 years were 94, 76 and 70%, respectively. We conclude that imiquimod seems to be an appropriate therapeutic alternative for the treatment of recurrent BCC in patients with associated co-morbidities.
authors.affiliation: Dermatology Unit, Complejo Hospitalario de Jaén, Jaén, Spain. ismenios2005@gmail.com
authors.forename: Ricardo
authors.initials: R
authors.lastname: RUIZ-VILLAVERDE
authors.forename: Daniel
authors.initials: D
authors.lastname: SANCHEZ-CANO
authors.forename: Pilar
authors.initials: P
authors.lastname: BURKHARDT-PEREZ
authors.forename: Ramon Naranjo
authors.initials: RN
authors.lastname: SINTES
mesh_terms: D000328:Adult; D000368:Aged; D000634:Aminoquinolines / Q000008:administration & dosage* / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002280:Basal Cell Carcinoma / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D000077271:Imiquimod; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod