Oseltamivir- and amantadine-resistant influenza viruses A (H1N1).
Surveillance of amantadine and oseltamivir resistance among influenza viruses was begun in Hong Kong in 2006. In 2008, while both A/Brisbane/59/2007-like and A/Hong Kong/2652/2006-like viruses (H1N1) were cocirculating, we detected amantadine and oseltamivir resistance among A/Hong Kong/2652/2006-like viruses (H1N1), caused by genetic reassortment or spontaneous mutation.
Cheng
Peter K C
PK
Centre for Health Protection, Hong Kong Special Administrative Region, People's Republic of China.
Leung
Tommy W C
TW
Ho
Eric C M
EC
Leung
Peter C K
PC
Ng
Anita Y Y
AY
Lai
Mary Y Y
MY
Lim
Wilina W L
WW
D000547:Amantadine / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D024882:Drug Resistance, Viral / Q000235:genetics*; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006723:Hong Kong; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000821:virology*; D053139:Oseltamivir / Q000494:pharmacology*; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000379:methods; D011159:Population Surveillance; D017422:Sequence Analysis, DNA
D000998:Antiviral Agents; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D053139:Oseltamivir; D000547:Amantadine