Characterization of the plasmid-borne quinolone resistance gene qnrB19 in Salmonella enterica serovar Typhimurium.
A qnrB19 gene variant, carried by an IncL/M-like plasmid, was detected in a multidrug Salmonella enterica serovar Typhimurium human strain with reduced susceptibility to ciprofloxacin. The genetic environment around the gene was fully sequenced (20 kb). A large gene cluster, containing the aph, qnrB19, and blaSHV-12-like resistance genes, is inserted inside a Tn3 transposon.
Dionisi
Anna Maria
AM
Istituto Superiore di Sanità, Department of Infectious, Parasitic and Immuno-Mediated Diseases, Viale Regina Elena 299, 00161 Rome, Italy.
Lucarelli
Claudia
C
Owczarek
Slawomir
S
Luzzi
Ida
I
Villa
Laura
L
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D004251:DNA Transposable Elements / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D019143:Evolution, Molecular; D008826:Microbial Sensitivity Tests; D005810:Multigene Family / Q000235:genetics; D010957:Plasmids / Q000235:genetics*; D015363:Quinolones / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D015363:Quinolones