Structural changes in the liver parenchyma and granulomas of mice with chronic BCG granulomatosis during therapy with composition of isoniazid and dialdehyde dextran.
Male BALB/c mice were intraperitoneally infected with BCG vaccine. The therapy with isoniazid or composition of isoniazid with dialdehyde dextran (intraperitoneally, twice a week for 5 months) was started 1 month after infection. The retention time of the isoniazid-dialdehyde dextran composition in hepatocytes was much longer compared to that of isoniazid. The mice receiving the composition of isoniazid and dialdehyde dextran were characterized by a more significant decrease in the number and size of BCG granulomas, lower severity of destructive changes in the liver parenchyma, and more pronounced reparative regeneration (compared to animals of the isoniazid group).
Shkurupiy
V A
VA
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. sck@soramn.ru
Kozyaev
M A
MA
D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use; D001500:BCG Vaccine / Q000009:adverse effects*; D003911:Dextrans / Q000494:pharmacology / Q000627:therapeutic use; D006099:Granuloma / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D007538:Isoniazid / Q000494:pharmacology / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000995:Antitubercular Agents; D001500:BCG Vaccine; D003911:Dextrans; C026948:dextran dialdehyde; D007538:Isoniazid