Effect of exercise training on cardiometabolic risk markers among sedentary, but metabolically healthy overweight or obese post-menopausal women with elevated blood pressure.
OBJECTIVE
To investigate the effect of exercise training on markers of the lipoprotein-lipid profile and inflammatory markers in post-menopausal overweight/obese women with a moderately elevated systolic blood pressure.


METHODS
A total of 267 women [mean body mass index (BMI)=32.0+/-5.7kg/m(2) and mean age=57.3+/-6.6 years] underwent a 6-month exercise intervention program. Exercise training was performed 3-4 times per week at a targeted heart rate corresponding to 50% of the maximal oxygen consumption.


RESULTS
Compared to baseline values, mean change in relative VO(2) max (the primary endpoint) was of 1.18+/-2.25mL/minkg (p<0.0001), mean weight loss was of 1.4+/-3.3kg (p<0.0001), mean reduction in waist circumference was of 2.4+/-6.9cm (p<0.0001) and systolic blood pressure did not change significantly (-1.2+/-13.0mmHg, NS). No changes were observed in markers of the lipoprotein-lipid profile. No changes were observed for plasma levels of C-reactive protein, interleukin-6, tumor-necrosis factor-alpha and adiponectin. Changes in VO(2) max were negatively associated with changes in body weight (r=-0.26, p<0.0001) and waist circumference (r=-0.16, p=0.01), but not with changes in cardiometabolic risk markers.


CONCLUSIONS
Although exercise training significantly increased cardiorespiratory fitness in these sedentary, but metabolically healthy obese/overweight women with a moderately elevated systolic blood pressure, no significant improvements were observed in their cardiometabolic risk profile.
Arsenault
Benoit J
BJ
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada.
Côté
Mélanie
M
Cartier
Amélie
A
Lemieux
Isabelle
I
Després
Jean-Pierre
JP
Ross
Robert
R
Earnest
Conrad P
CP
Blair
Steven N
SN
Church
Timothy S
TS
D052242:Adiponectin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D050177:Overweight / Q000150:complications / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D010101:Oxygen Consumption; D010809:Physical Fitness; D017698:Postmenopause; D011446:Prospective Studies; D012307:Risk Factors; D057185:Sedentary Behavior; D013997:Time Factors; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055105:Waist Circumference; D015431:Weight Loss
C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D008055:Lipids; D008074:Lipoproteins; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein