[Amlodipine combined with terazosin reduces postvoid residual and the risk of acute urinary retention].
OBJECTIVE
This prospective randomized double-blinded clinical trial was designed to explore the effects of amlodipine and the combination of amlodipine with terazosin in improving postvoid residual (PVR) in patients with lower urinary tract symptoms (LUTS) and concomitant hypertension.


METHODS
We randomly divided 360 LUTS patients with concomitant hypertension into a 5 mg amlodipine group, a 2 mg terazosin group and a 5 mg amlodipine plus 2 mg terazosin group, and measured PVR at the baseline and 4 weeks after the treatment.


RESULTS
For male patients with LUTS associate with hypertension, all of amlodipine (APVR = 6.8) , terazosin (APVR = 7. 6), and combination group (APVR = 8.8) can significant reduced the PVR (P < . 0.1), but no significant difference was found among three groups.


CONCLUSIONS
Amlodipine alone or combined with terazosin can improve the PVR of the LUTS patient effectively, but had no significant difference compared with terazosin.
Yang
Chun
C
Anhui Provincial Institute of Biomedicine, Anhui Medical University, Hefei, Anhui 230032, China.
Li
You-Long
YL
Fang
Jian
J
Zhang
Xiao
X
Liu
Hai-Peng
HP
Qin
Xian-Hui
XH
Xu
Xi-Ping
XP
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000368:Aged; D017311:Amlodipine / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome; D016055:Urinary Retention / Q000150:complications / Q000188:drug therapy*; D014563:Urodynamics / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D017311:Amlodipine; C041226:Terazosin; D011224:Prazosin