title: Clinical characteristics, management, and prognosis of octogenarians with acute heart failure admitted to cardiology wards: results from the Italian Survey on Acute Heart Failure.
abstract: BACKGROUND
  Heart failure is the leading cause of hospitalization among the elderly. This study compares clinical characteristics, management, and prognosis of octogenarians (OLD) with younger (YOUNG) patients in the Italian Survey on Acute Heart Failure (AHF).
  
  
  METHODS
  A nationwide, prospective, observational study on AHF was done. Two hundred six Italian departments with intensive cardiac care units enrolled 2,807 patients in 3 months.
  
  
  RESULTS
  Octogenarians (mean age 84 +/- 4 years) represented 28% of enrollees. Females were 50% in the OLD group versus 36% in the YOUNG group (P < .0001). Risk factors such as obesity, diabetes, and smoking were more frequent in the YOUNG group. Comorbidities such as anemia and renal dysfunction were more common in the OLD group (64% vs 53%, P < .0001, and 56% vs 43%, P < .0001). More octogenarians were admitted with cardiogenic shock and pulmonary edema, whereas younger patients presented more frequently in New York Heart Association class III to IV (P = .002). Left ventricular ejection fraction was measured in 90% of octogenarians versus 93% of the younger ones and was preserved in 41% of the OLD group versus 31% of the YOUNG group (P < .0001). Coronary angiography was performed in 20% of the YOUNG group and 10% of the OLD group. In-hospital mortality was twice as high in the OLD group (11.8% vs 5.6%, P < .001). In multivariable analysis, the strongest predictors of this event were use of inotropic agents, advanced age (> or =80 years), and elevated troponin at admission.
  
  
  CONCLUSIONS
  Octogenarians represent more than one fourth of the admissions for AHF and have a more severe clinical presentation. Their management is less aggressive, and treatments recommended by guidelines are underused. In-hospital mortality is high in the OLD group independently of left ventricular ejection fraction.
authors.affiliation: University Hospital S. Maria della Misericordia, Department of Cardiopulmonary Sciences, Udine, Italy. miani.daniela@aoud.sanita.fvg.it
authors.forename: Daniela
authors.initials: D
authors.lastname: Miani
authors.forename: Claudio
authors.initials: C
authors.lastname: Fresco
authors.forename: Donata
authors.initials: D
authors.lastname: Lucci
authors.forename: Maria Cecilia
authors.initials: MC
authors.lastname: Albanese
authors.forename: Lucio
authors.initials: L
authors.lastname: Gonzini
authors.forename: Paolo Maria
authors.initials: PM
authors.lastname: Fioretti
authors.forename: Aldo P
authors.initials: AP
authors.lastname: Maggioni
authors.forename: Luigi
authors.initials: L
authors.lastname: Tavazzi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016507:Cardiology Service, Hospital / Q000706:statistics & numerical data*; D015897:Comorbidity; D017023:Coronary Angiography / Q000706:statistics & numerical data; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006333:Heart Failure / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000628:therapy; D017052:Hospital Mortality; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D014600:Utilization Review / Q000706:statistics & numerical data; D055815:Young Adult