title: Percutaneous coronary interventions affect concentrations of interleukin 6 and its soluble receptors in coronary sinus blood in patients with stable angina.
abstract: Coronary stenting may create local inflammatory reaction. Interleukin 6 effects depend on the presence of soluble receptors (sIL-6R and sgp130) that facilitate or impede interleukin 6 signal transduction. Concentrations of interleukin 6 and its soluble receptors were assessed in aorta and coronary sinus after stenting in optimally treated stable angina patients scheduled for elective stenting. Baseline levels of interleukin 6 and its soluble receptors in patients did not differ from healthy controls. Initial levels of sIL-6R in aorta were significantly higher than in coronary sinus but this difference disappeared after intervention. Stenting caused interleukin 6 concentration increase to a similar extent both in coronary sinus and in aorta. Moreover, there was significantly higher sgp130 concentration in coronary sinus than in aorta. Coronary intervention increases concentration of interleukin 6 in patients with stable angina. It affects the cardiac level of interleukin 6 soluble receptors what may influence the local inflammatory reaction.
authors.affiliation: Medical University of Bialystok, Department of Cardiology, Bialystok, Poland. fizklin@wp.pl
authors.forename: Karol A
authors.initials: KA
authors.lastname: Kaminski
authors.forename: Anna
authors.initials: A
authors.lastname: Kozieradzka
authors.forename: Tomasz
authors.initials: T
authors.lastname: Bonda
authors.forename: Maciej
authors.initials: M
authors.lastname: Banach
authors.forename: Marcin
authors.initials: M
authors.lastname: Kozuch
authors.forename: Izabela
authors.initials: I
authors.lastname: Wojtkowska
authors.forename: Slawomir
authors.initials: S
authors.lastname: Dobrzycki
authors.forename: Pawel
authors.initials: P
authors.lastname: Kralisz
authors.forename: Konrad
authors.initials: K
authors.lastname: Nowak
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Prokopczuk
authors.forename: Dimitri P
authors.initials: DP
authors.lastname: Mikhailidis
authors.forename: Wlodzimierz J
authors.initials: WJ
authors.lastname: Musial
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000276:immunology* / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D054326:Coronary Sinus; D050822:Cytokine Receptor gp130 / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000276:immunology* / Q000628:therapy*; D012016:Reference Values; D015398:Signal Transduction / Q000502:physiology; D015607:Stents
chemical_list: C494199:IL6ST protein, human; D015850:Interleukin-6; D050822:Cytokine Receptor gp130