Effect of dialdehyde dextran on structural changes in the liver and lungs during chronic BCG granulomatosis.
Male BALB/c mice were intraperitoneally infected with BCG vaccine. Cytomorphological changes in BCG granulomas of the liver and lungs were compared during spontaneous tuberculous inflammation and after intraperitoneal injection of dialdehyde dextran for 5 months. Administration of dialdehyde dextran to mice infected with mycobacteria of BCG vaccine was followed by a decrease in the number and size of BCG granulomas in organs, contributed to the increase in the count of fibroblasts in hepatic and pulmonary granulomas, decreased the severity of destructive changes in the liver parenchyma, promoted reparative processes in hepatocytes, and reduced the degree of fibrosis in the liver and lungs due to a decrease in fibroplastic activity of fibroblasts in BCG granulomas.
Potapova
O V
OV
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Shkurupiy
V A
VA
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001500:BCG Vaccine / Q000009:adverse effects*; D003911:Dextrans / Q000494:pharmacology*; D006099:Granuloma / Q000188:drug therapy* / Q000209:etiology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000925:Anticoagulants; D001500:BCG Vaccine; D003911:Dextrans; C026948:dextran dialdehyde