title: Multicentric hyaline-vascular type Castleman disease presenting as an epidural mass causing paraplegia: a case report.
abstract: A 30-year-old woman presented with a 1-year history of cervical lymph node enlargement and paraparesis of 2 weeks' duration. Magnetic resonance imaging revealed an epidural mass extending from the second to fifth thoracic levels causing compressive myelopathy. The cervical lymph node biopsy revealed hyaline vascular multicentric Castleman disease. She was given dexamethasone and radiation therapy to the involved spine followed by 8 cycles of CHOP (cyclophosphamide/doxorubicin/vincristine/prednisone) chemotherapy. The patient achieved complete remission and is disease free 24 months after treatment. The case is being reported in view of its rarity and achievement of complete remission with chemotherapy and radiation therapy.
authors.affiliation: Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. ajayajaygupta2002@rediffmail.com
authors.forename: Ajay
authors.initials: A
authors.lastname: Gupta
authors.forename: Lalit
authors.initials: L
authors.lastname: Kumar
authors.forename: Ashok
authors.initials: A
authors.lastname: Karak
authors.forename: Sanjay
authors.initials: S
authors.lastname: Thulkar
authors.forename: Ruchi
authors.initials: R
authors.lastname: Rastogi
authors.forename: Sahibinder
authors.initials: S
authors.lastname: Bhatti
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D005871:Castleman Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D015174:Epidural Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D010264:Paraplegia / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D012074:Remission Induction; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone