title: Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis.
abstract: Activities of sphingomyelinase and ceramidase decreased in the liver in chronic toxic hepatitis and the balance between the levels of proapoptotic ceramide and antiapoptotic sphyngosine-1-phosphate shifts towards the latter substance. Pronounced changes in the qualitative and quantitative composition of fatty acids in the sphingomyelin cycle effector molecules were revealed.
authors.affiliation: Department of Biochemistry and Molecular Biology, Siberian State Medical University, Russian Ministry of Health, Tomsk, Russia. serebrov@ssmu.ru
authors.forename: V Yu
authors.initials: VY
authors.lastname: Serebrov
authors.forename: D I
authors.initials: DI
authors.lastname: Kuzmenko
authors.forename: P G
authors.initials: PG
authors.lastname: Burov
authors.forename: S V
authors.initials: SV
authors.lastname: Novitsky
mesh_terms: D000818:Animals; D055572:Ceramidases / Q000378:metabolism; D002518:Ceramides / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D006521:Hepatitis, Chronic / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D008246:Lysophospholipids / Q000378:metabolism; D008297:Male; D051381:Rats; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D013109:Sphingomyelins / Q000378:metabolism*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D002518:Ceramides; D008246:Lysophospholipids; D013109:Sphingomyelins; C060506:sphingosine 1-phosphate; D013108:Sphingomyelin Phosphodiesterase; D055572:Ceramidases; D013110:Sphingosine