[Structure and functions of isoforms of polyfunctional tumoral suppressor PML].
Polyfunctional protein PML contributes significantly in vital activity of cell. 11 isoforms of PML differ from one another by C-terminal domain. In spite of intensive research into the protein, the role of the isoforms in cellular processes remains obscure. In addition, the literature contains various names of the isoforms. The goal of this work was to review the structure of the PML gene, variants of alternative splicing of mPNA, and domain organization of corresponding protein forms. The PML isoforms were classified and functional specificity of each PML isoform was characterized: contribution to gene transcription, contribution to cell apoptosis, cell growth, immune response, formation of nuclear bodies.
Zinov'eva
M V
MV
Vaĭshlia
N A
NA
Vinogradova
T V
TV
Kopantsev
E P
EP
Sverdlov
E D
ED
D017398:Alternative Splicing; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D048708:Cell Growth Processes / Q000235:genetics; D002467:Cell Nucleus / Q000378:metabolism; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D009687:Nuclear Proteins / Q000145:classification* / Q000235:genetics* / Q000378:metabolism; D000071156:Promyelocytic Leukemia Protein; D020033:Protein Isoforms / Q000145:classification / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000502:physiology; D014157:Transcription Factors / Q000145:classification* / Q000235:genetics* / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000145:classification* / Q000235:genetics* / Q000378:metabolism; D016335:Zinc Fingers
D009687:Nuclear Proteins; D000071156:Promyelocytic Leukemia Protein; D020033:Protein Isoforms; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C070576:PML protein, human