[Prediction of phenotype R5/X4 of HIV-1 variants circulating in Russia, by using computer methods].
The paper presents the data of a comparative analysis of various bioinformation methods for evaluating the tropism of HIV-1 subtype A that is typical of Russia. The prevalence of CXCR4- and CCR5-tropic viruses among the variants prevailing in Russia was studied using the B-PSSM (sinsi) prediction method. No X4-tropic variants were found among 124 samples of HIV-1 isolated from the Russian patients not receiving antiretrovirus therapy.
Vasil'ev
A V
AV
Kazennova
E V
EV
Bobkova
M R
MR
D045744:Cell Line, Tumor; D019295:Computational Biology / Q000379:methods*; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000502:physiology*; D006801:Humans; D010446:Peptide Fragments / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D019713:Receptors, CCR5 / Q000502:physiology*; D019718:Receptors, CXCR4 / Q000502:physiology*; D012426:Russia / Q000453:epidemiology
D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments; D012367:RNA, Viral; D019713:Receptors, CCR5; D019718:Receptors, CXCR4