Ioversol-induced acute generalized exanthematous pustulosis: a case report.
BACKGROUND
Acute generalized exanthematous pustulosis (AGEP) is a relatively rare exfoliative dermatosis consisting of a generalized eruption of sterile, nonfollicular pustules arising on widespread erythematous and edematous skin that is usually caused by drugs. It has an acute onset, and patients often have systemic manifestations, including leukocytosis, fever, and hemodynamic instability. Rarely has AGEP been associated with radiocontrast dyes.


METHODS
We describe an 84-year-old man who developed AGEP on 2 separate occasions after receiving an infusion of an ioversol-containing radiocontrast dye. Conclusion Acute generalized exanthematous pustulosis may occur after the use of intravenous radiocontrast dye.
Hammerbeck
Ashley A
AA
Division of Dermatology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Daniels
Natalie H
NH
Callen
Jeffrey P
JP
D000369:Aged, 80 and over; D001707:Biopsy, Needle; D003287:Contrast Media / Q000009:adverse effects*; D003875:Drug Eruptions / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D014283:Triiodobenzoic Acids / Q000009:adverse effects* / Q000494:pharmacology
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C054871:ioversol