title: Morphofunctional study of the therapeutic efficacy of human mesenchymal and neural stem cells in rats with diffuse brain injury.
abstract: We studied the effect of transplantation of human stem cells from various tissues on reparative processes in the brain of rats with closed craniocerebral injury. Combined treatment with standard drugs and systemic administration of xenogeneic stem cells had a neuroprotective effect. The morphology of neurons rapidly returned to normal after administration of fetal neural stem cells. Fetal mesenchymal stem cells produced a prolonged effect on proliferative activity of progenitor cells in the subventricular zone of neurogenesis. Adult mesenchymal stem cells had a strong effect on recovery of the vascular bed in ischemic regions.
authors.affiliation: Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, Russia.
authors.forename: A F
authors.initials: AF
authors.lastname: Tsyb
authors.forename: V V
authors.initials: VV
authors.lastname: Yuzhakov
authors.forename: L M
authors.initials: LM
authors.lastname: Roshal'
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
authors.forename: A G
authors.initials: AG
authors.lastname: Konoplyannikov
authors.forename: G N
authors.initials: GN
authors.lastname: Sushkevich
authors.forename: N D
authors.initials: ND
authors.lastname: Yakovleva
authors.forename: I E
authors.initials: IE
authors.lastname: Ingel'
authors.forename: L N
authors.initials: LN
authors.lastname: Bandurko
authors.forename: L E
authors.initials: LE
authors.lastname: Sevan'kaeva
authors.forename: L N
authors.initials: LN
authors.lastname: Mikhina
authors.forename: N K
authors.initials: NK
authors.lastname: Fomina
authors.forename: M V
authors.initials: MV
authors.lastname: Marei
authors.forename: Zh B
authors.initials: ZhB
authors.lastname: Semenova
authors.forename: O A
authors.initials: OA
authors.lastname: Konoplyannikova
authors.forename: S Sh
authors.initials: SSh
authors.lastname: Kal'sina
authors.forename: L A
authors.initials: LA
authors.lastname: Lepekhina
authors.forename: I V
authors.initials: IV
authors.lastname: Semenkova
authors.forename: E V
authors.initials: EV
authors.lastname: Agaeva
authors.forename: A S
authors.initials: AS
authors.lastname: Shevchuk
authors.forename: L N
authors.initials: LN
authors.lastname: Pavlova
authors.forename: O Yu
authors.initials: OY
authors.lastname: Tokarev
authors.forename: O V
authors.initials: OV
authors.lastname: Karaseva
authors.forename: T A
authors.initials: TA
authors.lastname: Chernyshova
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000628:therapy*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar