title: Synthesis and characterization of new galanthamine derivatives comprising peptide moiety.
abstract: New analogues of galanthamine containing peptide fragments either at 6 or 11 position, were synthesized by reaction between galanthamine molecule and dipeptides and tripeptide, derivatives of N-(3,4-dichlorophenyl)-D,L-Ala-OH. The best results according to yields, easily purification of the target products, and simplicity of the scheme realisation was achieved by using of cyanomethyl ester of Boc-Gly-OH as activated compound.
authors.affiliation: Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 8 Kl. Ohridski blvd., 1756 Sofia, Bulgaria. lvezenkov@yahoo.com
authors.forename: Lyubomir T
authors.initials: LT
authors.lastname: Vezenkov
authors.forename: Maria G
authors.initials: MG
authors.lastname: Georgieva
authors.forename: Dantcho L
authors.initials: DL
authors.lastname: Danalev
authors.forename: Tchavdar B
authors.initials: TB
authors.lastname: Ivanov
authors.forename: Galya I
authors.initials: GI
authors.lastname: Ivanova
mesh_terms: D004151:Dipeptides / Q000138:chemical synthesis; D005702:Galantamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D009842:Oligopeptides / Q000138:chemical synthesis*
chemical_list: D004151:Dipeptides; D009842:Oligopeptides; D005702:Galantamine