title: [Acute abdomen for perforated gastrointestinal stromal tumor (GIST). A case report].
abstract: The authors report on a case of voluminous perforated gastrointestinal stromal tumor (GIST) of small intestine and make a review to the light of most recent clinicopathologic advancements. The first clinical manifestation as acute abdomen due to their perforation extremely rare. Gastrointestinal stromal tumor (GIST) represent a rare group of multiform tumors with various biological behaviour. Were identified in the past as leiomyomas, leiomyosarcomas or leiomyoblastomas, has been reclassified on immunochemical features, with a positive expression of Kit (CD117 antigen). Traditionally the prognostic factors of these tumour are: mitotic rate, tumor size and anatomic site. The complete surgical resection and use of imatinib mesylate (Gleevec) are the best available approach.
authors.affiliation: Dipartimento di Patologia Umana dell'Università di Messina. aversaci@unime.it
authors.forename: Antonino
authors.initials: A
authors.lastname: Versaci
authors.forename: Antonio
authors.initials: A
authors.lastname: Macrì
authors.forename: Maddalena
authors.initials: M
authors.lastname: Grosso
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Terranova
authors.forename: Grazia
authors.initials: G
authors.lastname: Leonello
authors.forename: Antonio
authors.initials: A
authors.lastname: Ieni
authors.forename: Giovanna
authors.initials: G
authors.lastname: Rivoli
authors.forename: Ciro
authors.initials: C
authors.lastname: Famulari
mesh_terms: D000006:Abdomen, Acute / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D046152:Gastrointestinal Stromal Tumors / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D006801:Humans; D007416:Intestinal Perforation / Q000150:complications* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology / Q000601:surgery; D007580:Jejunal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit