title: The metabolic syndrome of omega3-depleted rats. I. Liver data.
abstract: Second-generation rats depleted in long-chain polyunsaturated omega3 fatty acids were recently proposed as a novel animal model for the metabolic syndrome. In the present study, a dietary deprivation of omega3 acids for 3-7 months was found sufficient to provoke in 6-week-old normal rats the same alteration of the fatty acid content and profile of liver phospholipids and triglycerides as that otherwise prevailing in the second-generation omega3-depleted rats, with emphasis on a severe decrease in their omega3 fatty acid content, alterations in the relative contribution of and ratio between selected long-chain polyunsaturated omega6 fatty acids, saturated and monodesaturated fatty acids and precursors of nervonic acid, and liver steatosis. When the omega3-depleted rats were exposed, after the first 7 months of the present experiments and for 2-4 weeks to a diet supplemented with 5% (w/w) flaxseed oil, most of these hepatic variables returned towards or beyond control values. In both the omega3-depleted rats and control animals, however, the eventual exposure to the flaxseed oil-enriched diet failed to suppress liver steatosis and, on the contrary, provoked a further increase in liver triglyceride content. It is proposed, therefore, that the present approach represents a simple and realistic animal model to study the consequences of omega3-depletion. Moreover, the results suggest that to oppose such consequences, e.g. liver steatosis, it may be necessary to combine the dietary supply of omega3 acids with a suitable control of food intake, in both qualitative and quantitative terms.
authors.affiliation: Laboratory of Experimental Hormonology, Université Libre de Bruxelles, B-1070 Brussels, Belgium. malaisse@ulb.ac.be
authors.forename: Willy J
authors.initials: WJ
authors.lastname: Malaisse
authors.forename: Nurdan
authors.initials: N
authors.lastname: Bulur
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Mirjam
authors.initials: M
authors.lastname: Hacquebard
authors.forename: Laurence
authors.initials: L
authors.lastname: Portois
authors.forename: Abdullah
authors.initials: A
authors.lastname: Sener
authors.forename: Yvon A
authors.initials: YA
authors.lastname: Carpentier
mesh_terms: D000818:Animals; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
chemical_list: D015525:Fatty Acids, Omega-3; D010743:Phospholipids; D014280:Triglycerides