Potassium dichromate-induced changes on urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes.
It has been reported that potassium dichromate-induced nephrotoxicity is evidenced by diminution in creatinine clearance, increase in urinary protein, and structural damage to the proximal tubules. Damage to tissue often leads to the release of enzymes from the injured cells into the extracellular fluids. The aim of this study was to establish whether potassium dichromate induces changes in the urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes. Our results show that the administration of a single intraperitoneal dose of potassium dichromate decreased the activity of such enzymes in urine.
Becerra-Torres
Sergio Lucio
SL
Departamentos de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, México. luciobecerratorres@hotmail.com
Rodríguez-Vázquez
María Luisa
ML
Medina-Ramírez
Iliana Ernestina
IE
Jaramillo-Juárez
Fernando
F
D000818:Animals; D018826:CD13 Antigens / Q000187:drug effects* / Q000378:metabolism / Q000652:urine; D004785:Environmental Pollutants / Q000633:toxicity; D007274:Injections, Intraperitoneal; D008297:Male; D011192:Potassium Dichromate / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D005723:gamma-Glutamyltransferase / Q000187:drug effects* / Q000378:metabolism / Q000652:urine
D004785:Environmental Pollutants; D005723:gamma-Glutamyltransferase; D018826:CD13 Antigens; D011192:Potassium Dichromate