Therapeutic efficacy of a composition of amphotericin B and dialdehyde dextran in kidney damage in mice of various strains with systemic candidiasis.
The therapeutic efficacy of a composition of amphotericin B and dialdehyde dextran was much higher than that of amphotericin B in the therapy for systemic candidiasis. This conclusion was derived from the earlier and progressive decrease in the number and size of candidal granulomas in the kidneys. The composition of amphotericin B and dialdehyde dextran was more potent than amphotericin B in decreasing the nephrotoxic effect of C. albicans. The opposite strains of CBA and C57Bl/6 mice differed in morphological signs of granulomatosis in the kidneys, but not in the nephrotoxic effect of C. albicans metabolites.
Pristavka
A A
AA
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Nadeev
A P
AP
Travin
M A
MA
Shkurupiy
V A
VA
D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D003911:Dextrans / Q000494:pharmacology / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
D000925:Anticoagulants; D000935:Antifungal Agents; D003911:Dextrans; C026948:dextran dialdehyde; D000666:Amphotericin B