Antithrombogenic and antiplatelet activities of extract from Maackia amyrensis wood.
Antithrombogenic and antiplatelet effects of a new drug, containing isoflavonoids (extract from the wood of Maackia amyrensis, a Far Eastern plant), were studied. A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by application of 10% iron chloride solution on the vessel. The drug increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied rats. The reference drug ethinylestradiol (25 mug/kg intragastrically during 14 days) potentiated the antiaggregant effect of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats.
Plotnikova
A M
AM
Siberian Division of the Russian Academy of Medical Sciences, Tomsk Research Center, Institute of Pharmacology, Siberian State Medical University, Tomsk, Russia. mbp2001@mail.ru
Shulgau
Z T
ZT
Plotnikova
T M
TM
Aliev
O I
OI
Kulesh
N I
NI
Mischenko
N P
NP
Fedoreyev
S A
SA
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D007529:Isoflavones / Q000494:pharmacology; D029901:Maackia / Q000737:chemistry*; D010052:Ovariectomy; D010936:Plant Extracts / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology
D005343:Fibrinolytic Agents; D007529:Isoflavones; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D004997:Ethinyl Estradiol