Dendritic peptide-based carriers for gene delivery.
Gene delivery research has come a long way in recent years but there are still a number of barriers preventing therapeutic gene-based drugs reaching the market. Dendrimers or multi-component carriers may provide a means to overcome the issues of gene degradation and transport to the target site by employing different entities in the same carrier. We will discuss some recent approaches to gene delivery using modified dendrimers. We also discuss our work to deliver oligonucleotides and genes using dendritic peptide-based carriers.
Coles
Daniel J
DJ
School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.
Toth
Istvan
I
D050091:Dendrimers / Q000737:chemistry*; D018390:Gene Targeting; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009841:Oligonucleotides / Q000008:administration & dosage*; D010455:Peptides / Q000737:chemistry
D050091:Dendrimers; D009841:Oligonucleotides; D010455:Peptides