Antioxidant and cytotoxic activities of Caesalpinia pulcherrima wood.
Antioxidant and cytotoxic activities of the methanolic and aqueous extracts of Caesalpinia pulcherrima wood were studied in in vitro models. Both extracts exhibited strong antioxidant activity, as evidenced by the low IC50 values in both 1,1-diphenyl-2-picryl hydrazyl (DPPH), nitric oxide and superoxide scavenging methods; the values were found to be less or comparable to those of gallic acid, the standard used. To determine the cytotoxic activity, extracts were tested for toxic effects to brine shrimp larvae. In this assay, the methanolic extract had little effect, but aqueous extract was relatively toxic. The antioxidant and cytotoxic activities may be attributed to the total phenolic content in the wood.
Pawar
C R
CR
Department of Pharmacognosy, R. C. Patel College of Pharmacy, Shirpur, Dhule 425 405 (MS), India. chaitalipawar.2006@rediffmail.com
Mutha
R E
RE
Landge
A D
AD
Jadhav
R B
RB
Surana
S J
SJ
D000818:Animals; D001156:Artemia / Q000187:drug effects; D029911:Caesalpinia / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000494:pharmacology* / Q000633:toxicity*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity*; D014934:Wood / Q000737:chemistry*
D016166:Free Radical Scavengers; D010936:Plant Extracts