[Coronary artery disease attack caused by cytotoxic chemotherapy].
Capesitabine is a orally administered cytotoxic drug metabolized to 5-fluorouracil and is widely used in large intestine cancer and breast cancer therapy. Its adverse effects against the heart have been considered to be rare. We describe four patients, who were diagnosed with an attack of coronary artery disease during capesitabine therapy on the basis of coronary spasm. This adverse effect should be kept in mind as a cause of chest pain symptoms and the medication discontinued in a suspected case.
Ilveskoski
Erkki
E
Pirkanmaan Sairaanhoitopiiri, Sydänkeskusliikelaitos, Tampere.
Nikus
Kjell
K
Tanner
Minna
M
Eskola
Markku
M
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D000069287:Capecitabine; D002637:Chest Pain / Q000139:chemically induced*; D003329:Coronary Vasospasm / Q000139:chemically induced*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007414:Intestinal Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil