title: Chitosan glutamate hydrogels with local anesthetic activity for buccal application.
abstract: Hydrogels for the buccal application of the anesthetic drug lidocaine hydrochloride (LDC) were prepared using chitosan glutamate (CHG), a soluble salt of chitosan, or a binary mixture of CHG and glycerin, at different weight ratios. The in vitro drug release was studied at the pH value of saliva to assess the effect of the different formulations on drug delivery. The anesthetic activity of mucoadhesive LDC-CHG hydrogels was assessed in vivo after application on the buccal mucosa, compared to commercial semisolid formulations containing the same drug. LDC-loaded hydrogels can be proposed for the symptom relief of aphthosis or other painful mouth diseases.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Catania, viale A. Doria, 6, Catania I-95125, Italy. r.pignatello@unict.it
authors.forename: R
authors.initials: R
authors.lastname: Pignatello
authors.forename: L
authors.initials: L
authors.lastname: Basile
authors.forename: G
authors.initials: G
authors.lastname: Puglisi
mesh_terms: D000278:Administration, Buccal; D000328:Adult; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D001672:Biocompatible Materials; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage; D004355:Drug Stability; D005260:Female; D018698:Glutamic Acid / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects* / Q000378:metabolism; D013678:Technology, Pharmaceutical
chemical_list: D000779:Anesthetics, Local; D000891:Anti-Infective Agents, Local; D001672:Biocompatible Materials; D004337:Drug Carriers; D020100:Hydrogels; D018698:Glutamic Acid; D048271:Chitosan; D008012:Lidocaine