Study on acetylcholinesterase inhibition induced by endogenous neurotoxin with an enzyme-semiconductor photoelectrochemical system.
The integration of Au-doped TiO(2) nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO(2) hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin.
Zhu
Wei
W
Department of Chemistry, East China Normal University, Shanghai 200062, P.R. China.
An
Ya-Rui
YR
Luo
Xiao-Min
XM
Wang
Fei
F
Zheng
Jiao-Hong
JH
Tang
Lin-Lin
LL
Wang
Qing-Jiang
QJ
Zhang
Zhong-Hai
ZH
Zhang
Wen
W
Jin
Li-Tong
LT
D000110:Acetylcholinesterase / Q000187:drug effects* / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods; D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D006046:Gold; D007546:Isoquinolines / Q000494:pharmacology*; D007700:Kinetics; D043942:Nanotubes; D009498:Neurotoxins / Q000494:pharmacology*; D010777:Photochemistry; D012666:Semiconductors; D014025:Titanium
D002800:Cholinesterase Inhibitors; D007546:Isoquinolines; C089303:N-methylsalsolinium; D009498:Neurotoxins; C009495:titanium dioxide; D006046:Gold; D014025:Titanium; D000110:Acetylcholinesterase