D-serine regulation: a possible therapeutic approach for central nervous diseases and chronic pain.
D-Serine, an endogenous modulator of NMDA receptors has been shown to play a vital role in many neuropsychiatric functions such as learning, memory, nociception and implicated in pathological conditions like schizophrenia and Alzheimer's disease. We propose possible therapeutic approaches for some CNS diseases and chronic pain, targeting the D-serine levels by manipulating its uptake, biosynthesis and metabolism.
Sethuraman
R
R
Department of Anaesthesia, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074.
Lee
T L
TL
Tachibana
S
S
D000818:Animals; D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000378:metabolism*; D002908:Chronic Disease / Q000188:drug therapy; D006801:Humans; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism*; D012694:Serine / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism
D012694:Serine