[The effect of preoperative administration of heparin on the heparin resistance development].
BACKGROUND
Heparin resistance is relatively frequent problem in cardio surgery. We were try to determine real occurrence heparin resistance before operation.


OBJECTIVE
Purpose of the project--to find the real frequency of heparin resistance in patients who will undergo a cardio surgical operation. To find out the dependence between the pre-operational application of heparin and the development of heparin resistance.


METHODS
We recorded pre-operative administration heparin in patients. If the dose of heparin was 5 mg/kg and more then we insert patients to the group heparin resistant.


RESULTS
In our collection was heparin resistance in 203 patients from 624, it was 32.5%. Test agreement relative frequency with 22% was throw out--p < 0.001--heparin resistance in our group statistically different from 22% heparin resistance was higher than hypothesis. Heparin before operation was administrate 181 patients, which make to 29%. For administration of heparin was hypothesis of independence thrown (p < 0.001).


CONCLUSIONS
Results of our works confirmed statistically significant occurrence of heparin resistance in patients that was administration heparin pre-operative. Heparin resistance occurred against presumption 22% in 32.5% in our group. It is statistic significant difference.
Brzek
V
V
Kardiochirurgická klinika FN a LF UK Hradec Králové. vbrzek@seznam.cz
Lonský
V
V
Jiska
S
S
Kubícek
J
J
Nováková
D
D
Valentová
P
P
Bímová
J
J
Volt
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D004351:Drug Resistance; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D011300:Preoperative Care
D000925:Anticoagulants; D006493:Heparin