Brugada syndrome whose ST-segment changes were enhanced by antihistamines and antiallergenic drugs.
We describe a case of Brugada syndrome, in which a coved type ST-segment elevation was enhanced by antihistamines and antiallergenic drugs. The patient had been treated with four kinds of antihistamines and antiallergenic drugs. The twelve-lead ECG exhibited a coved type ST-segment elevation in leads V(1) and V(2), and their enhancement was induced by pilsicainide. After discontinuing those drugs, the ST segment elevation in leads V(1) and V(2) became reduced. An ICD implantation was selected for the therapy since ventricular fibrillation was induced. Our report discusses the possible contribution of antihistamines and antiallergenic drugs to the Brugada type ST-segment changes.
Matsuki
Motoki
M
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College.
Sato
Nobuyuki
N
Matsuda
Kanako
K
Yamaki
Masaru
M
Nakagawa
Naoki
N
Sakamoto
Naka
N
Ota
Hisanobu
H
Tanabe
Yasuko
Y
Takeuchi
Toshiharu
T
Akasaka
Kazumi
K
Kawamura
Yuichiro
Y
Hasebe
Naoyuki
N
D018926:Anti-Allergic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D053840:Brugada Syndrome / Q000503:physiopathology*; D017147:Defibrillators, Implantable; D004485:Eczema / Q000188:drug therapy; D004562:Electrocardiography; D006633:Histamine Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy
D018926:Anti-Allergic Agents; D006633:Histamine Antagonists