title: Myositis associated with localized lipodystrophy: an unrecognized condition?
abstract: Lipodystrophies represent a heterogeneous group of diseases characterized by altered body fat repartition and often metabolic alterations. Here we illustrate a 20 year old male with myositis in association with localized lipodystrophy. Immunohistochemical stainings revealed a regular pattern of dystrophin, dysferlin, sarcoglycans, and theletonin. Furtermore, there was no evidence of Lamin A/C deficiency. A nearly identical clinical and histological picture has been described in three patients up to now. Although it is difficult to speculate on a causative pathophysiological mechanism at this time, it is possible that this association represents an unrecognized condition.
authors.affiliation: Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany. hans-juergen.gdynia@uni-ulm.de
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Gdynia
authors.forename: P
authors.initials: P
authors.lastname: Weydt
authors.forename: A
authors.initials: A
authors.lastname: Ernst
authors.forename: S
authors.initials: S
authors.lastname: Klein
authors.forename: A-D
authors.initials: AD
authors.lastname: Sperfeld
authors.forename: A
authors.initials: A
authors.lastname: Riecker
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002081:Buttocks; D016516:CD4-CD8 Ratio; D000073939:Dysferlin; D016189:Dystrophin / Q000378:metabolism; D006801:Humans; D008060:Lipodystrophy / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009220:Myositis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D049031:Sarcoglycans / Q000378:metabolism; D017211:Treatment Failure
chemical_list: D015415:Biomarkers; C114839:DYSF protein, human; D000073939:Dysferlin; D016189:Dystrophin; D008565:Membrane Proteins; D009124:Muscle Proteins; D049031:Sarcoglycans; D011239:Prednisolone