Copper-associated liver diseases.
The liver is essential for copper metabolism. Copper metabolism is highly conserved between different species. This article provides the reader with an overview of copper storage disorders in humans and animals. Diagnosis and treatment of copper-associated hepatitis are described, and breed-specific characteristics of the disease are explained. A literature review references publications about the disease in companion animals.
Hoffmann
Gaby
G
Department of Clinical Sciences of Companion Animals, Utrecht University, P.O. Box 80.154, Utrecht NL 3508TD, The Netherlands. g.hoffmann@uu.nl
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000628:therapy / Q000662:veterinary; D002779:Cholestasis / Q000150:complications / Q000662:veterinary; D003300:Copper / Q000009:adverse effects* / Q000378:metabolism*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D004285:Dogs; D006801:Humans; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D008664:Metal Metabolism, Inborn Errors / Q000150:complications / Q000662:veterinary*; D051379:Mice; D051381:Rats; D012756:Sheep
D003300:Copper