title: Gold-catalyzed synthesis of 2-aryl-3-fluoropyrroles.
abstract: The gold-catalyzed cyclization and dehydrofluorination of gem-difluorohomopropargylamines provides a novel access to 2-aryl-3-fluoropyrroles. Difluorinated homopropargylamines are prepared by the addition of gem-difluoropropargyllithium reagents to arylated N-tosylimines.
authors.affiliation: Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Surmont
authors.forename: Guido
authors.initials: G
authors.lastname: Verniest
authors.forename: Norbert
authors.initials: N
authors.lastname: De Kimpe
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006845:Hydrocarbons, Fluorinated; D011758:Pyrroles; D006046:Gold