Quantitative spectroscopic imaging with in situ measurements of tissue water T1, T2, and density.
The use of tissue water as a concentration standard in proton magnetic resonance spectroscopy ((1)H-MRS) of the brain requires that the water proton signal be adjusted for relaxation and partial volume effects. While single voxel (1)H-MRS studies have often included measurements of water proton T(1), T(2), and density based on additional (1)H-MRS acquisitions (e.g., at multiple echo or repetition times), this approach is not practical for (1)H-MRS imaging ((1)H-MRSI). In this report we demonstrate a method for using in situ measurements of water T(1), T(2), and density to calculate metabolite concentrations from (1)H-MRSI data. The relaxation and density data are coregistered with the (1)H-MRSI data and provide detailed information on the water signal appropriate to the individual subject and tissue region. We present data from both healthy subjects and a subject with brain lesions, underscoring the importance of water parameter measurements on a subject-by-subject and voxel-by-voxel basis.
Gasparovic
C
C
Department of Neurology, University of New Mexico, Albuquerque, New Mexico 87131, USA. chuck@unm.edu
Neeb
H
H
Feis
D L
DL
Damaraju
E
E
Chen
H
H
Doty
M J
MJ
South
D M
DM
Mullins
P G
PG
Bockholt
H J
HJ
Shah
N J
NJ
D000465:Algorithms; D001834:Body Water / Q000737:chemistry*; D001923:Brain Chemistry; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D014867:Water / Q000032:analysis*
D014867:Water