RVB1/RVB2: running rings around molecular biology.
RVB1/RVB2 (also known as Pontin/Reptin, TIP49/TIP48, RuvbL1/RuvbL2, ECP54/ECP51, INO80H/INO80J, TIH1/TIH2, and TIP49A/TIP49B) are two highly conserved members of the AAA+ family that are present in different protein and nucleoprotein complexes. Recent studies implicate the RVB-containing complexes in many cellular processes such as transcription, DNA damage response, snoRNP assembly, cellular transformation, and cancer metastasis. In this review, we discuss recent advances in our understanding of RVB-containing complexes and their role in these pathways.
Jha
Sudhakar
S
Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Jordan 1240, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA.
Dutta
Anindya
A
D000074183:ATPases Associated with Diverse Cellular Activities; D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D004249:DNA Damage; D004265:DNA Helicases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D008938:Mitosis; D008958:Models, Molecular; D008969:Molecular Sequence Data; D020718:Ribonucleoproteins, Small Nucleolar / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D015533:Transcriptional Activation / Q000502:physiology
D002352:Carrier Proteins; D020718:Ribonucleoproteins, Small Nucleolar; D029701:Saccharomyces cerevisiae Proteins; D000074183:ATPases Associated with Diverse Cellular Activities; D004265:DNA Helicases; C486549:RUVBL1 protein, human; C122079:RUVBL2 protein, human