title: Inhibitory effects of beta-cyclodextrin and trehalose on nanofibril and AGE formation during glycation of human serum albumin.
abstract: The effects of beta-cyclodextrin (beta-CyD) and trehalose on glycation of human serum albumin (HSA) were studied. These additives reduced AGEs and nanofibril formation of HSA under in vitro glycation conditions and improved its helical structure. These were accomplished through direct interactions of them with HSA and alterations in solute-protein interactions.
authors.affiliation: Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
authors.forename: Esmaeel
authors.initials: E
authors.lastname: Sharifi
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Sattarahmady
authors.forename: Mehran
authors.initials: M
authors.lastname: Habibi-Rezaei
authors.forename: Mohammad
authors.initials: M
authors.lastname: Farhadi
authors.forename: Nader
authors.initials: N
authors.lastname: Sheibani
authors.forename: Faizan
authors.initials: F
authors.lastname: Ahmad
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Moosavi-Movahedi
mesh_terms: D002942:Circular Dichroism; D005947:Glucose / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D012709:Serum Albumin / Q000378:metabolism*; D012995:Solubility; D013050:Spectrometry, Fluorescence; D014199:Trehalose / Q000494:pharmacology*; D047392:beta-Cyclodextrins / Q000494:pharmacology*
chemical_list: D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D047392:beta-Cyclodextrins; D014199:Trehalose; D005947:Glucose; C031215:betadex