title: Preconditioning with high mobility group box 1 protein protects against myocardial ischemia-reperfusion injury.
abstract: OBJECTIVE
  To investigate whether preconditioning with high mobility group box 1 protein (HMGB1) could reduce myocardial ischemia-reperfusion (I/R) injury.
  
  
  RESULTS
  Infarct size, lactate dehydrogenase (LDH), creatine kinase (CK), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were assessed. HMGB1 preconditioning reduced significantly the infarct size induced by I/R. The LDH, CK, TNF-α and IL-6 levels were significantly decreased by HMGB1 preconditioning compared to those in the I/R group.
  
  
  CONCLUSIONS
  The present study suggested that preconditioning with HMGB1 could induce HMGB1 tolerance and protect against myocardial I/R injury.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Hu
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Bo
authors.initials: B
authors.lastname: Cui
authors.forename: Changwu
authors.initials: C
authors.lastname: Xu
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: He
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D024243:HMGB1 Protein / Q000008:administration & dosage*; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002316:Cardiotonic Agents; D024243:HMGB1 Protein