Serum uric acid and prehypertension among Chinese adults.
BACKGROUND
Raised blood pressure is emerging as an independent risk factor for cardiovascular diseases and diabetes. We examined the relation between serum uric acid and prehypertension and the modification effects of age, obesity, fasting glucose, and lipids in Chinese adults.


METHODS
The study samples are from a community-based health examination survey in China. A total of 14 451 patients with normal range of blood pressure were included.


RESULTS
The odds ratios [ORs, 95% confidence interval (CI)] of prehypertension across increasing quintiles of serum uric acid were 1.00, 1.04 (0.92-1.18), 1.21 (1.06-1.38), 1.26 (1.09-1.45), and 1.36 (1.17-1.58) (P for trend < 0.0001), adjusting for age, sex, body mass index, glucose, and lipids. The regression splines suggested a possible threshold effect for serum uric acid of approximately 200 micromol/l on prehypertension risk. The associations were significant in both men and women, but was not significant in older individuals aged above 60 years. In addition, fasting glucose significantly interacted with uric acid (P for interaction < 0.0001). The associations were more evident in patients with low (P = 0.0005) and median glucose levels (P = 0.002) than in those with high glucose levels.


CONCLUSIONS
Serum uric acid was associated with prehypertension, independent of metabolic risk factors. The associations were not significant in old individuals. Fasting glucose may modify the associations.
Liang
Jun
J
Department of Endocrinology, the Central Hospital of Xuzhou, XuZhou Clinical School of Xuzhou Medical College, Jiangsu, China.
Xue
Ying
Y
Zou
Caiyan
C
Zhang
Tong
T
Song
Huaidong
H
Qi
Lu
L
D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
D001786:Blood Glucose; D014527:Uric Acid