Improvement of cardiac function after granulocyte-colony stimulating factor-mobilized peripheral blood mononuclear cell implantation in a patient with non-ischemic dilated cardiomyopathy associated with thromboangiitis obliterans.
Cardiac involvement is a rare complication with thromboangiitis obliterans (TAO). We report a 29-year-old man with TAO accompanied with non-ischemic dilated cardiomyopathy. He had no history of heart disease, but echocardiogram demonstrated diffuse hypokinesis and dilated left ventricle. Coronary angiography revealed no organic stenotic lesion. For limb salvage, he was treated with granulocyte-colony stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cell (PBMNC) implantation on his right leg. Not only ischemic leg symptoms, but also plasma level of BNP and (123)I-metaiodobenzylguanidine scintigraphic parameters improved after 24 weeks. G-CSF-mobilized PBMNC implantation could be an effective approach to treating non-ischemic cardiomyopathy.
Kakihana
Ayano
A
Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine, Okinawa.
Ishida
Akio
A
Miyagi
Megumi
M
Ishiki
Tetsuya
T
Okumura
Koichiro
K
Kamiyama
Tomomasa
T
Ohya
Yusuke
Y
Takishita
Shuichi
S
D000328:Adult; D016913:Blood Component Transfusion / Q000379:methods*; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000637:transplantation*; D023821:Limb Salvage / Q000379:methods; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood; D013318:Stroke Volume / Q000502:physiology; D013919:Thromboangiitis Obliterans / Q000150:complications / Q000503:physiopathology / Q000628:therapy*
D020097:Natriuretic Peptide, Brain; D016179:Granulocyte Colony-Stimulating Factor