title: [Past, present and future of bone grafting].
abstract: OBJECTIVE
  To study the past, present and future of bone grafting.
  
  
  METHODS
  Related literature on bone grafting in recent years was extensively reviewed.
  
  
  RESULTS
  Bone grafting had a history over 300 years, a variety of bone grafting candidates including autografting, allografting, xenografting, synthetic and composite bone grafting had been utilized in clinical orthopedics at present. But bone autografting and allografting represented the preferred alternatives for bone grafting. It would be important trend in bone grafting to fulfill the optimizing design of biomaterials and constructing composite bone substitutes with cells, factors and scaffolds.
  
  
  CONCLUSIONS
  The future bone grafting might be focused on how to achieve the goal of the rapid osseointegration as well as the physiological bone reconstruction.
authors.affiliation: The Trauma Institute of Hebei Province, Orthopedic Center, Affiliated Hospital of North China Coal Medical University, Tangshan Hebei, 063000, P.R. China.
authors.forename: Huiping
authors.initials: H
authors.lastname: Song
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wang
mesh_terms: D018786:Bone Substitutes; D016025:Bone Transplantation; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
chemical_list: D018786:Bone Substitutes