[Frequency of detection of human herpesvirus type 6 DNA in patients of Public Independent Central Hospital in Warsaw in years 2003-2007].
Human herpesvirus 6 (HHV-6) has been recognized as a potential significant pathogen in haemopoietic stem cell transplant recipients. Different clinical manifestations have been described including fever, skin rash, bone marrow suppression and encephalitis. The aim of the study was to show frequency of presence of human herpesvirus type 6 DNA in patients of Public Independent Central Clinical Hospital in Warsaw in years 2003-2007. 1357 clinical samples taken from 71 a group of adult recipients of allogeneic HSCT were tested for the presence of HHV-6 DNA using the quantitative in-house real-time PCR assay. Positive results were obtained in 12.5% of all examinations made during described period and also in 35.2% of investigated patients. All of them developed fever of unknown origin, and over 50% had GvHD features. Nine individuals from this group died during detectable HHV-6 viremia.
Dzieciatkowski
Tomasz
T
Katedra i Zakład Mikrobiologii Lekarskiej, Warszawski Uniwersytet Medyczny. dzieciatkowski@wp.pl
Przybylski
Maciej
M
Kawecki
Dariusz
D
Gieryńska
Małgorzata
M
Sulowska
Agata
A
Torosian
Tigran
T
Luczak
Mirosław
M
Jedrzejczak
Wiesław Wiktor
WW
Młynarczyk
Grazyna
G
D000914:Antibodies, Viral / Q000097:blood*; D004279:DNA, Viral / Q000097:blood*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006779:Hospitals, Public / Q000706:statistics & numerical data; D006801:Humans; D011044:Poland / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D019349:Roseolovirus Infections / Q000175:diagnosis* / Q000453:epidemiology*; D012680:Sensitivity and Specificity; D019562:Viral Load
D000914:Antibodies, Viral; D004279:DNA, Viral