Polymer/silica hybrid hollow nanospheres with pH-sensitive drug release in physiological and intracellular environments.
Hybrid hollow nanospheres of chitosan-silica templated by chitosan-poly(acrylic acid) nanoparticles are fabricated in a complete aqueous system, which provide a pH-sensitive switch in physiological and sub-cell environments for the release of loaded drug.
Yan
Eryun
E
National Laboratory of Solid State Microstructure, Department of Material Science and Engineering, Nanjing University, Nanjing, 210093, P.R. China.
Ding
Yin
Y
Chen
Changjing
C
Li
Rutian
R
Hu
Yong
Y
Jiang
Xiqun
X
D000180:Acrylic Resins / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival; D048271:Chitosan / Q000737:chemistry; D015179:Colorectal Neoplasms; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles; D046529:Microscopy, Electron, Transmission; D054118:Nanospheres / Q000737:chemistry*; D012822:Silicon Dioxide
D000180:Acrylic Resins; D004337:Drug Carriers; C065246:chitosan-poly(acrylic acid); D012822:Silicon Dioxide; D004317:Doxorubicin; D048271:Chitosan