title: Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.
abstract: We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.
authors.affiliation: Vernalis (R&D) Ltd, Granta Park, Cambridge CB21 6GB, UK. t.hart@vernalis.com
authors.forename: Terance
authors.initials: T
authors.lastname: Hart
authors.forename: Alba T
authors.initials: AT
authors.lastname: Macias
authors.forename: Karen
authors.initials: K
authors.lastname: Benwell
authors.forename: Teresa
authors.initials: T
authors.lastname: Brooks
authors.forename: Jalanie
authors.initials: J
authors.lastname: D'Alessandro
authors.forename: Pawel
authors.initials: P
authors.lastname: Dokurno
authors.forename: Geraint
authors.initials: G
authors.lastname: Francis
authors.forename: Ben
authors.initials: B
authors.lastname: Gibbons
authors.forename: Timothy
authors.initials: T
authors.lastname: Haymes
authors.forename: Guy
authors.initials: G
authors.lastname: Kennett
authors.forename: Sean
authors.initials: S
authors.lastname: Lightowler
authors.forename: Howard
authors.initials: H
authors.lastname: Mansell
authors.forename: Natalia
authors.initials: N
authors.lastname: Matassova
authors.forename: Anil
authors.initials: A
authors.lastname: Misra
authors.forename: Anthony
authors.initials: A
authors.lastname: Padfield
authors.forename: Rachel
authors.initials: R
authors.lastname: Parsons
authors.forename: Robert
authors.initials: R
authors.lastname: Pratt
authors.forename: Alan
authors.initials: A
authors.lastname: Robertson
authors.forename: Steven
authors.initials: S
authors.lastname: Walls
authors.forename: Melanie
authors.initials: M
authors.lastname: Wong
authors.forename: Stephen
authors.initials: S
authors.lastname: Roughley
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D000818:Animals; D001384:Azetidines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008956:Models, Chemical; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D043884:Receptor, Cannabinoid, CB1 / Q000737:chemistry; D013237:Stereoisomerism; D014508:Urea / Q000737:chemistry*; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D001384:Azetidines; D004791:Enzyme Inhibitors; D010880:Piperidines; D043884:Receptor, Cannabinoid, CB1; D014508:Urea; D000099252:Fatty Acid Amide Hydrolases; C545365:VER 156084; C082735:azetidine