Fucoidan extracted from Fucus evanescens brown algae corrects immunity and hemostasis disorders in experimental endotoxemia.
Fucoidan extracted from brown algae (Fucus evanescens) was used for correction of immunity and hemostasis disorders in experimental endotoxemia induced by injection of LPS. Fucoidan reduced the elevated levels of proinflammatory cytokines (TNF-alpha, IL-1, IL-6) and partially arrested hypercoagulation phenomena, thus improving animal resistance to LPS.
Kuznetsova
T A
TA
Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia. niiem_vl@mail.ru
D000818:Animals; D044645:Fucus / Q000737:chemistry*; D020141:Hemostatic Disorders / Q000188:drug therapy*; D007109:Immunity / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use*
D011134:Polysaccharides; C007789:fucoidan