Early malignant transformation of a petroclival meningothelial meningioma.
Although some authors have reported the malignant transformation of meningiomas, there has been no previous report describing that a meningothelial meningioma transformed into an atypical meningioma within 1 year. This report documents a 57-year-old woman who presented with right hearing disturbance. Magnetic resonance imaging revealed a right petroclival meningioma. The tumor was subtotally removed and was diagnosed to be a meningothelial meningioma. Seven months after surgery, a recurrence of the tumor was confirmed. The diagnosis of this recurrent tumor was an atypical meningioma. The MIB-1 index and the percent of p53 protein-positive cells in the primary tumor were 4.6% and 35.4%, respectively, whereas those of the recurrent tumor were 34.7% and 33.1%, respectively. A chromosomal DNA copy number loss was observed on 1p, 6q, 10, 14q, and -22q detected in both the primary and the recurrent tumors. These results suggest that the present case had a potentially malignant tumor in the early stage, although it had the histological features of benign meningiomas. An evaluation of the MIB-1 index, as well as the expression of p53 and chromosomal aberrations, may be useful for predicting the malignant transformation of meningiomas.
Ohba
Shigeo
S
Department of Neurosurgery, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan. shigeo.ohba@gmail.com
Yoshida
Kazunari
K
Hirose
Yuichi
Y
Ikeda
Eiji
E
Kawase
Takeshi
T
D002471:Cell Transformation, Neoplastic; D002533:Cerebral Angiography; D004247:DNA / Q000235:genetics; D005260:Female; D020233:Gait Disorders, Neurologic; D018628:Gene Dosage; D006311:Hearing Disorders / Q000209:etiology; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008576:Meningeal Arteries / Q000601:surgery; D008577:Meningeal Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53; D004247:DNA