[Genome wide studies of mental disorders].
In these two years, genome wide association studies of SNPs and CNVs in large samples of patients with bipolar disorder or schizophrenia were published. In bipolar disorder, association with SNPs of ANK3 and CACNA1C was found by the combined analysis of three sample sets, which was consistent across three sample sets. In schizophrenia, two deletions, 1q21.1 and 15q13.3, were found to increase the risk of schizophrenia with odds ratios larger than 10. These two deletions are regarderd as the causes of genome diseases that accompany facial dysmorphism and developmental disorders.
Kato
Tadafumi
T
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute.
D055106:Genome-Wide Association Study; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*