Morphological study of the efficiency of isoniazid and dialdehyde dextran composition in the treatment of mice with BCG granulomatosis.
Male BALB/c mice were intraperitoneally injected with BCG vaccine. After 1 month therapy was started: isoniazid or composition of isoniazid with dialdehyde dextran (CID) obtained by chemical and radiochemical methods. The therapeutic efficiency evaluated by the number granulomas in the liver and lungs and granuloma size was higher in mice treated with CID obtained by the radiochemical method in comparison with mice treated with isoniazid and with CID obtained by the chemical method. Hepatotoxicity evaluated by volume density of degenerative hepatocytes and necrotic zones was higher in mice treated with CID obtained by the radiochemical method than in animals treated with isoniazid, because CID contained free isoniazid and isoniazid bound to dialdehyde dextran.
Shkurupiy
V A
VA
Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. sck@soramn.ru
Kozyaev
M A
MA
Potapova
O V
OV
D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001500:BCG Vaccine / Q000009:adverse effects; D003911:Dextrans / Q000627:therapeutic use*; D006099:Granuloma / Q000188:drug therapy* / Q000209:etiology; D007538:Isoniazid / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000995:Antitubercular Agents; D001500:BCG Vaccine; D003911:Dextrans; C026948:dextran dialdehyde; D007538:Isoniazid