title: Early detection of local RFA site recurrence using total liver volume perfusion CT initial experience.
abstract: OBJECTIVE
  The aim of this study was to prospectively evaluate the feasibility of a novel total liver volume perfusion computed tomographic technique in demonstrating treatment-site recurrence of liver metastases after radiofrequency ablation (RFA).
  
  
  METHODS
  Eleven patients considered to be at increased risk for local RFA-site tumor recurrence underwent both positron emission tomography (PET) and perfusion computed tomography (CTP): a 12-phase scan of the entire liver acquired before and 11 times after contrast injection. After coregistration, blood flow maps were created using the maximum slope method.
  
  
  RESULTS
  In all cases, the CTP-derived blood flow maps fully paralleled the PET images in showing either the absence (nine of 13 lesions) or presence (four of 13 lesions) of local RFA-site recurrence. Marginal lesions with high hepatic arterial perfusion (>50 mL/min/100 g) and low portal venous perfusion (<10 mL/min/100 g) represented recurring vital tumor tissue (P < .05).
  
  
  CONCLUSIONS
  Total liver volume CTP seems feasible for the detection and localization of treatment-site recurrence after RFA.
authors.affiliation: Department of Radiology, VU University Medical Center, De Boelelaan 1117, Postbus 7057 Amsterdam, The Netherlands. mr.meijerink@vumc.nl
authors.forename: Martijn R
authors.initials: MR
authors.lastname: Meijerink
authors.forename: Jan Hein T M
authors.initials: JH
authors.lastname: van Waesberghe
authors.forename: Lineke
authors.initials: L
authors.lastname: van der Weide
authors.forename: Petrousjka
authors.initials: P
authors.lastname: van den Tol
authors.forename: Sybren
authors.initials: S
authors.lastname: Meijer
authors.forename: Emile F
authors.initials: EF
authors.lastname: Comans
authors.forename: Richard P
authors.initials: RP
authors.lastname: Golding
authors.forename: Cornelis
authors.initials: C
authors.lastname: van Kuijk
mesh_terms: D000368:Aged; D017115:Catheter Ablation / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000517:prevention & control*; D055420:Perfusion Imaging / Q000379:methods*; D010865:Pilot Projects; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome