title: Efficacy of sumatriptan in two pediatric cases with abdominal pain-related functional gastrointestinal disorders: does the mechanism overlap that of migraine?
abstract: We successfully treated 2 pediatric cases of abdominal pain-related functional gastrointestinal disorder with sumatriptan. When 9 years old, patient 1 developed periodic abdominal pain that was intractable to medication and remitted spontaneously. She was diagnosed with abdominal migraine, categorized as H2c in the Rome III criteria for functional gastrointestinal disorders. At age 12, intranasal sumatriptan relieved her pain, and her attacks halted 2 years later. Patient 2 was a 9-year-old girl diagnosed with attention-deficit hyperactivity disorder (ADHD), who began to have intermittent abdominal pain of variable severity, which sometimes restricted daily activity. She was diagnosed with childhood functional abdominal pain syndrome, categorized as H2d1 using the Rome III criteria. Intranasal sumatriptan also relieved her pain. These cases suggest that the mechanism of pain in abdominal pain-related functional gastrointestinal disorders is similar to that of migraine, with probable central hypersensitivity, at least in a subset of cases.
authors.affiliation: Department of Pediatrics, Tohoku University School of Medicine, Sendai, Miyagi, 980-8574, Japan. kakisuke@mui.biglobe.ne.jp
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kakisaka
authors.forename: Keisuke
authors.initials: K
authors.lastname: Wakusawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Haginoya
authors.forename: Akiko
authors.initials: A
authors.lastname: Saito
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Uematsu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Sato
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tsuchiya
mesh_terms: D015746:Abdominal Pain / Q000188:drug therapy* / Q000209:etiology; D000281:Administration, Intranasal; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D005767:Gastrointestinal Diseases / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D018170:Sumatriptan / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D018170:Sumatriptan