Dedifferentiated liposarcoma with rhabdomyoblastic differentiation in an 8-year-old girl.
The development of a liposarcoma during childhood is extremely rare. We report a case of dedifferentiated liposarcoma arising in the left thigh of an 8-year-old girl. Morphological and immunohistochemical studies revealed occasional rhabdomyoblastic differentiation in the dedifferentiated component. The identical cells were co-mingling with the well-differentiated liposarcoma component. This is the first description of such a case of liposarcoma occurring in a child.
Okamoto
Sumika
S
Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan. okamotosum@kochi-u.ac.jp
Machinami
Rikuo
R
Tanizawa
Taisuke
T
Matsumoto
Seiichi
S
Lee
Gang-Hong
GH
Ishikawa
Yuichi
Y
D002454:Cell Differentiation; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008080:Liposarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013848:Thigh / Q000473:pathology
C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2