Detection of high-risk human papillomaviruses in verrucae of patients with mycosis fungoides and Sézary syndrome: a case series.
BACKGROUND
Mycosis fungoides (MF)/Sézary syndrome (SS) patients are immunocompromised and thus may be susceptible to high-risk human papillomavirus (HPV) infections that are difficult to treat.


METHODS
Three patients with verrucous skin lesions, 2 of whom had coexisting squamous cell carcinoma (SCC) near the verruca biopsy site, had biopsies of verruca for histologic examination. HPV typing was performed on fresh verruca biopsies by nested polymerase chain reaction.


RESULTS
A single type of high-risk HPV was identified in each patient's lesion.


CONCLUSIONS
HPV may have acted as a cocarcinogen in the development of SCC in two patients and extensive condyloma acuminatum in one.
Vidulich
Kelley A
KA
Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas 77027, USA. kvidulich@hotmail.com
Rady
Peter L
PL
He
Qin
Q
Tyring
Stephen K
SK
Duvic
Madeleine
M
D000328:Adult; D001706:Biopsy; D004279:DNA, Viral / Q000032:analysis; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification*; D052161:Human papillomavirus 18 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012751:Sezary Syndrome / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000473:pathology / Q000821:virology; D012878:Skin Neoplasms / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*; D014860:Warts / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*
D004279:DNA, Viral