Effect of antibodies to glutamate and GABA on the stress response in C57Bl/6 mice.
We studied the effect of antibodies to glutamate and GABA (active immunization with conjugates of glutamate--bovine serum albumin and GABA--bovine serum albumin) on the course of combined water-immersion stress in C57Bl/6 mice. Preimmunization of animals with the conjugate of glutamate--bovine serum albumin was accompanied by strong production of antibodies to glutamate, which reduced the majority of signs of the stress response. Antibodies to GABA had no effect on the development of stress.
Zaharova
I A
IA
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. izaharova_zia@mail.ru
Vetrile
L A
LA
Evsyeev
V A
VA
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001522:Behavior, Animal; D002417:Cattle; D018698:Glutamic Acid / Q000737:chemistry / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013312:Stress, Physiological / Q000276:immunology*; D005680:gamma-Aminobutyric Acid / Q000737:chemistry / Q000276:immunology*
D000906:Antibodies; D012710:Serum Albumin, Bovine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid