New families of enantiopure cyclohexenone cis-diol, o-quinol dimer and hydrate metabolites from dioxygenase-catalysed dihydroxylation of phenols.
Toluene dioxygenase-catalysed cis-dihydroxylation of phenols has led to the discovery of new enantiopure cyclohexenone cis-diol, o-quinol dimer and phenol hydrate metabolites having synthetic potential.
Boyd
Derek R
DR
School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast, UKBT9 5AG. dr.boyd@qub.ac.uk
Sharma
Narain D
ND
Malone
John F
JF
Allen
Christopher C R
CC
D055162:Biocatalysis; D018360:Crystallography, X-Ray; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry; D019281:Dimerization; D049308:Dioxygenases / Q000378:metabolism*; D006873:Hydroquinones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
D003512:Cyclohexanones; D006873:Hydroquinones; D010636:Phenols; D014867:Water; C036468:cyclohexanone; D049308:Dioxygenases