title: Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm.
abstract: OBJECTIVE
  To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA).
  
  
  METHODS
  Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (-1360C>T, and +649C>T) in men with AAA (n=678) and in controls (n=659) was examined using multivariate analyses. The association with AAA expansion (n=638) was also assessed.
  
  
  RESULTS
  In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected.
  
  
  CONCLUSIONS
  MMP2 -1360C>T and +649C>T variants are not risk factors for AAA.
authors.affiliation: School of Surgery, University of Western Australia, Fremantle Hospital, Fremantle, WA 6959, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Smallwood
authors.forename: N
authors.initials: N
authors.lastname: Warrington
authors.forename: R
authors.initials: R
authors.lastname: Allcock
authors.forename: F
authors.initials: F
authors.lastname: van Bockxmeer
authors.forename: L J
authors.initials: LJ
authors.lastname: Palmer
authors.forename: B
authors.initials: B
authors.lastname: Iacopetta
authors.forename: J
authors.initials: J
authors.lastname: Golledge
authors.forename: P E
authors.initials: PE
authors.lastname: Norman
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008403:Mass Screening; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D014904:Western Australia / Q000453:epidemiology
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2