title: Leprosy reaction as a manifestation of immune reconstitution inflammatory syndrome: a case series of a Brazilian cohort.
abstract: Several case reports have demonstrated that the immune reconstitution inflammatory syndrome induces reversal reaction in HIV and leprosy-coinfected patients. The present study describes 10 cases of immune reconstitution inflammatory-associated reversal reaction. The patients evolved satisfactorily despite presenting a more severe form of the disease and the fact that three required an additional use of corticoids. The present study, the largest case series published to date, demonstrates that leprosy reaction is a manifestation of immune reconstitution.
authors.forename: Vinicius Martins
authors.initials: VM
authors.lastname: Menezes
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Sales
authors.forename: Ximena
authors.initials: X
authors.lastname: Illarramendi
authors.forename: Alice
authors.initials: A
authors.lastname: Miranda
authors.forename: Mariza
authors.initials: M
authors.lastname: Gonçalves Morgado
authors.forename: Maria Clara
authors.initials: MC
authors.lastname: Gutierrez-Galhardo
authors.forename: Euzenir
authors.initials: E
authors.lastname: Nunes Sarno
authors.forename: José Augusto
authors.initials: JA
authors.lastname: da Costa Nery
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications* / Q000276:immunology; D007918:Leprosy / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D055815:Young Adult