You don't need a PHD to grow a tumor.
Prolyl hydroxylases (PHDs) perceive intracellular oxygen tension and signal hypoxia-inducible factors (HIFs) to induce hypoxia-adaptive processes such as angiogenesis. A paper from Chan and colleagues in the June issue of Cancer Cell demonstrates that PHD2 inactivation in tumor cells accelerates tumor growth via HIF-independent, NF-kappaB-mediated changes in tumor angiogenesis.
Kim
Jung-whan
JW
Molecular Biology Section, Division of Biological Sciences, University of California, La Jolla, CA 92093, USA.
Johnson
Randall S
RS
D000818:Animals; D049109:Cell Proliferation; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply / Q000201:enzymology* / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000201:enzymology; D010100:Oxygen / Q000378:metabolism; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D015398:Signal Transduction
D051793:Hypoxia-Inducible Factor 1; D016328:NF-kappa B; D011393:Procollagen-Proline Dioxygenase; D010100:Oxygen