title: Estradiol modulates uterine 18 kDa translocator protein gene expression in uterus and kidney of rats.
abstract: We examined the effect of ovariectomy, with and without estradiol treatment, on 18 kDa translocator protein (TSPO) gene expression and its binding density in the uterus and kidney of rats. Ovariectomy causes a significant decrease in uterine, but not renal TSPO binding density, while estradiol treatment of ovariectomized rats restored TSPO binding density in the uterus. These TSPO density levels did not correlate with steady state or new RNA transcription. Our in vivo study suggests that estradiol is responsible for the maintenance of uterine TSPO density via transcriptional mechanisms. Our in vivo study also suggests that in the kidney estradiol appears to operate via post-transcriptional mechanisms to maintain TSPO density.
authors.affiliation: Department of Molecular Pharmacology, the Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
authors.forename: Caroline
authors.initials: C
authors.lastname: Mazurika
authors.forename: Leo
authors.initials: L
authors.lastname: Veenman
authors.forename: Ronit
authors.initials: R
authors.lastname: Weizman
authors.forename: Miri
authors.initials: M
authors.lastname: Bidder
authors.forename: Svetlana
authors.initials: S
authors.lastname: Leschiner
authors.forename: Idit
authors.initials: I
authors.lastname: Golani
authors.forename: Ilana
authors.initials: I
authors.lastname: Spanier
authors.forename: Gary
authors.initials: G
authors.lastname: Weisinger
authors.forename: Moshe
authors.initials: M
authors.lastname: Gavish
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D008970:Molecular Weight; D010052:Ovariectomy; D011485:Protein Binding / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D012333:RNA, Messenger; D011963:Receptors, GABA-A; C069997:Tspo protein, rat; D004958:Estradiol