title: Fatal hemorrhage in two renal graft recipients with multi-drug resistant Pseudomonas aeruginosa infection.
abstract: Pseudomonas aeruginosa (PA) infections occurring after renal transplantation (RT) represent a potentially life-threatening complication. We present 2 cases of early death following RT in which PA was transmitted, possibly from the donor to the recipients, despite preoperative cultures that were negative. The donor had developed PA-related bilateral pneumonia while in the intensive care unit. However, after appropriate antibiotic therapy, no signs of infection were present at the time of organ retrieval and cultures were negative. Both recipients received a renal graft from the same donor and developed multi-drug resistant (MDR)-PA infections with bacterial phenotypes and resistances similar to the donor. The first recipient died 9 days after RT from rupture of a false aneurysm of the external iliac artery, caused by a fully thickened PA-related arteritis. The second recipient died postoperatively on day 10 after rupture of an aneurysm in the right vertebral artery. Our experience shows that MDR-PA infection early after RT may be a catastrophic event. Specific anti-PA antibiotic therapy in RT patients during the perioperative period is recommended in the case of PA infection in the donor, even after apparent successful therapy with negative cultures.
authors.affiliation: Transplant Unit, San Salvatore Hospital, University of L'Aquila, L'Aquila, Italy. gorlando@wfubmc.edu
authors.forename: G
authors.initials: G
authors.lastname: Orlando
authors.forename: P
authors.initials: P
authors.lastname: Di Cocco
authors.forename: G
authors.initials: G
authors.lastname: Gravante
authors.forename: M
authors.initials: M
authors.lastname: D'Angelo
authors.forename: A
authors.initials: A
authors.lastname: Famulari
authors.forename: F
authors.initials: F
authors.lastname: Pisani
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001167:Arteritis / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D007083:Iliac Artery / Q000382:microbiology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000150:complications* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D014711:Vertebral Artery / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents