title: Estimating the number of clusters via system evolution for cluster analysis of gene expression data.
abstract: The estimation of the number of clusters (NC) is one of crucial problems in the cluster analysis of gene expression data. Most approaches available give their answers without the intuitive information about separable degrees between clusters. However, this information is useful for understanding cluster structures. To provide this information, we propose system evolution (SE) method to estimate NC based on partitioning around medoids (PAM) clustering algorithm. SE analyzes cluster structures of a dataset from the viewpoint of a pseudothermodynamics system. The system will go to its stable equilibrium state, at which the optimal NC is found, via its partitioning process and merging process. The experimental results on simulated and real gene expression data demonstrate that the SE works well on the data with well-separated clusters and the one with slightly overlapping clusters.
authors.affiliation: School of Mathematics and Computer Science, Fujian Normal University, Fuzhou 350007, China. wangkjun@yahoo.com
authors.forename: Kaijun
authors.initials: K
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.forename: Junying
authors.initials: J
authors.lastname: Zhang
authors.forename: Jiyang
authors.initials: J
authors.lastname: Dong
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D003198:Computer Simulation; D030541:Databases, Genetic; D015870:Gene Expression; D008957:Models, Genetic; D015233:Models, Statistical