First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy.
The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.
Serduc
Raphaël
R
Université de Toulouse, UPS, Centre de Recherche Cerveau et Cognition, Toulouse, France. raph.serduc@gmail.com
Bräuer-Krisch
Elke
E
Bouchet
Audrey
A
Renaud
Luc
L
Brochard
Thierry
T
Bravin
Alberto
A
Laissue
Jean Albert
JA
Le Duc
Géraldine
G
D000818:Animals; D001932:Brain Neoplasms / Q000532:radiotherapy*; D018316:Gliosarcoma / Q000532:radiotherapy*; D008297:Male; D011879:Radiotherapy Dosage; D051381:Rats; D011916:Rats, Inbred F344; D017356:Synchrotrons