Regulation of endochondral ossification by osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)].
In neonatal rat metatarsal organ culture, a bell-shaped dose-related curve in length of mineralized area, increases in the height of proliferative and hypertrophic zones, in the number of hypertrophic chondrocyte and in the amount of Runx2 mRNA, were revealed after treatment with OGP(10-14). We conclude that OGP(10-14) accelerates bone growth.
Chen
Zhixin
Z
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, PR China.
Chang
Min
M
Peng
Yali
Y
Zhao
Li
L
Zhan
Yurui
Y
Wang
Lijing
L
Wang
Rui
R
D000818:Animals; D000831:Animals, Newborn; D001846:Bone Development / Q000187:drug effects; D050659:Core Binding Factor Alpha 1 Subunit / Q000235:genetics; D004723:Endorphins / Q000494:pharmacology*; D006132:Growth Plate / Q000187:drug effects; D006657:Histones / Q000494:pharmacology*; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D008682:Metatarsal Bones / Q000187:drug effects; D051379:Mice; D041681:NIH 3T3 Cells; D009842:Oligopeptides / Q000494:pharmacology; D009924:Organ Culture Techniques; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology*; D010446:Peptide Fragments / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats
D050659:Core Binding Factor Alpha 1 Subunit; D004723:Endorphins; D006657:Histones; D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; D010446:Peptide Fragments; D012333:RNA, Messenger; C493717:Runx2 protein, rat; C050198:historphin; C074533:osteogenic growth peptide