[Lack of association between MMR vaccination and the incidence of autism in children: a case-control study].
The matched case-control study has been undertook to investigate whether measles, mumps, and rubella (MMR) vaccine may be casually associated with autism in children. Cases were children to 14-year old with diagnosis of core autism or atypical autism. Controls were matched on age, sex and general practice. The 96 cases and 192 controls were included. The study provides strong evidence against association of autism with both MMR and a single measles individual vaccine. Additionally children vaccinated with MMR, regardless of age of vaccination (to 18th, 24th and 36th month of life), had risk equal half of that of single measles vaccinated (for vaccinated to 18th month OR=0.41 95%PU: 0.20-0.85). Our findings confirm that MMR vaccination is not associated with an increased risk of autism in children.
Mrozek-Budzyn
Dorota
D
Zakład Epidemiologii Katedra Epidemiologii i Medycyny Zapobiegawczej Uniwersytet Jagielloński Collegium Medicum.
Kiełtyka
Agnieszka
A
Majewska
Renata
R
D000293:Adolescent; D001321:Autistic Disorder / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007223:Infant; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D011044:Poland; D018570:Risk Assessment / Q000706:statistics & numerical data; D012307:Risk Factors
D022542:Measles-Mumps-Rubella Vaccine