[Severe bacterial keratitis and activity of fluoroquinolones].
OBJECTIVE
To study the microbiological characteristics of patients with severe bacterial keratitis in Bordeaux, France, as well as the species' resistance to fluoroquinolones.


METHODS
We conducted a retrospective study of 57 patients presenting severe bacterial keratitis over 20 months. The positive bacteriological cultures of the corneal smears, bacteria, and the antibiogram were listed.


RESULTS
Fifty-seven patients with severe bacterial keratitis were hospitalized from March 2005 to November 2006. Pseudomonas aeruginosa (n=17), Staphylococcus aureus (n=16), and coagulase-negative Staphylococcus (n=10) were the most frequent species. P. aeruginosa was sensitive in 100% of cases to ciprofloxacin, S. aureus was sensitive in 94% of cases to ciprofloxacin, and coagulase-negative Staphylococcus species were sensitive in 100% of cases to ciprofloxacin. No significant different was noted between ciprofloxacin, levofloxacin, and moxifloxacin on the bacteria studied (p>0.05).


CONCLUSIONS
In this study, except for the Streptococcus species, ciprofloxacin was effective against the species responsible for severe bacterial keratitis.
Mesplié
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N
Service d'Ophtalmologie, Centre Hospitalier Universitaire Pellegrin, Bordeaux, France. sannico@aliceadsl.fr
Kérautret
J
J
Léoni
S
S
Dubois
V
V
Colin
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007634:Keratitis / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones