title: Aphyllin, the first isoferulic acid glycoside and other phenolics from Tamarix aphylla flowers.
abstract: The first glycosylated isoferulic acid, isoferulic acid 3-O-beta-glucopyranoside, together with the new phenolics, tamarixetin 3,3'-di-sodium sulphate and dehydrodigallic acid dimetyl ester have been characterized from a flower extract of Tamarix aphylla. The structures were established on the basis of spectral data. The extract exhibited a distinct radical scavenging effect and to improve the viability of human keratinocytes (HaCaT cells). Also, the known isoferulic acid and ferulic acid which have been determined to be the major components of the investigated extract by HPLC/ESI mass spectrometric screening have been separated, characterized and evaluated as active antioxidants and as cell activity stimulating agents as well.
authors.affiliation: Department of Phytochemistry, Division of Pharmaceutical Industries, National Research Center, Dokki, Egypt. mahmoudnawwarhesham@yahoo.com
authors.forename: M A M
authors.initials: MA
authors.lastname: Nawwar
authors.forename: S A M
authors.initials: SA
authors.lastname: Hussein
authors.forename: N A
authors.initials: NA
authors.lastname: Ayoub
authors.forename: K
authors.initials: K
authors.lastname: Hofmann
authors.forename: M
authors.initials: M
authors.lastname: Linscheid
authors.forename: M
authors.initials: M
authors.lastname: Harms
authors.forename: K
authors.initials: K
authors.lastname: Wende
authors.forename: U
authors.initials: U
authors.lastname: Lindequist
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002934:Cinnamates / Q000302:isolation & purification / Q000494:pharmacology*; D004396:Coloring Agents; D003373:Coumaric Acids / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry; D016166:Free Radical Scavengers / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects; D000432:Methanol; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D032363:Tamaricaceae / Q000737:chemistry*; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D002934:Cinnamates; D004396:Coloring Agents; D003373:Coumaric Acids; D016166:Free Radical Scavengers; D005960:Glucosides; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D012997:Solvents; D013778:Tetrazolium Salts; D013844:Thiazoles; C543445:aphyllin; C004999:ferulic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C022616:thiazolyl blue; C008180:isoferulic acid; D000432:Methanol