title: [Diagnostic value of lesion-directed prostate biopsy under TRUS in early detection of prostate cancer].
abstract: OBJECTIVE
  To evaluate lesion-directed biopsy in improving the detection rate of early prostate cancer (PCa) and in differentiating PCa from other prostate pathological changes.
  
  
  METHODS
  We performed TRUS-guided prostate biopsy for 95 patients suspected of PCa, each subjected to extended random biopsy plus lesion-directed biopsy, and analyzed the sonographic characteristics and pathological findings.
  
  
  RESULTS
  PCa was detected in 35 of the patients (36.8%), including 16 hypoechoic (45.7%), 4 hyperechoic (11.4%), 10 isoechoic (28.6%) and 5 mixed hetero-echoic lesions (14.3%). Of the 35 PCa cases, 17 (46.2%) were within T2b, 70.6% (12/17) of which were detected by lesion-directed biopsy and 29.4% (5/17) by sextant biopsy, the former obviously higher than the latter (P < 0.05).
  
  
  CONCLUSIONS
  Lesion-directed prostate biopsy under TRUS can significantly improve the early diagnosis of prostate cancer, increase convenience and reduce patients' pain, but is not sufficient to replace traditional sextant biopsy.
authors.affiliation: Department of Ultrasound, The Second Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. zhujiang1963@126.com
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Liu
authors.forename: Chuan-Jun
authors.initials: CJ
authors.lastname: Du
authors.forename: Zhe-Wei
authors.initials: ZW
authors.lastname: Zhang
authors.forename: Yi-Qing
authors.initials: YQ
authors.lastname: Qiu
authors.forename: Yu
authors.initials: Y
authors.lastname: Gong
authors.forename: Jing-Rui
authors.initials: JR
authors.lastname: Liu
authors.forename: Yu-Rong
authors.initials: YR
authors.lastname: Hong
authors.forename: Zhi-Yan
authors.initials: ZY
authors.lastname: Luo
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D018084:Ultrasonography, Interventional