Role of cyclooxygenase in the chorionic gonadotropin regulation of human neutrophil activity.
The involvement of cyclooxygenase in the regulation of the main functions of human neutrophils by chorionic gonadotropin was studied. The inhibitory effect of the hormone on phagocytosis and oxidative activity of neutrophils is completely or partially canceled under conditions of cyclooxygenase blocking. In addition, gonadotropin directly induces the expression of cyclooxygenase inducible form mRNA in these cells. These data indicate that realization of the suppressive effects of chorionic gonadotropin in the neutrophils is partially linked with activation of cyclooxygenase (both the constitutive and inducible forms of the enzyme).
Kuklina
E M
EM
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia. ibis_07@mail.ru
Shirshev
S V
SV
D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004008:Diclofenac / Q000494:pharmacology; D005260:Female; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology*; D010587:Phagocytosis / Q000187:drug effects; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D006063:Chorionic Gonadotropin; D016861:Cyclooxygenase Inhibitors; D004008:Diclofenac; D011451:Prostaglandin-Endoperoxide Synthases