Characteristics of community- and hospital-acquired meticillin-resistant Staphylococcus aureus strains carrying SCCmec type IV isolated in Malaysia.
Community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) occurring among hospital isolates in Malaysia has not been reported previously. As CA-MRSA reported worldwide has been shown to carry SCCmec types IV and V, the aim of this study was to determine the SCCmec types of MRSA strains collected in Malaysia from November 2006 to June 2008. From a total of 628 MRSA isolates, 20 were SCCmec type IV, whilst the rest were type III. Further characterization of SCCmec type IV strains revealed 11 sequence types (STs), including ST22, with the majority being ST30/Panton-Valentine leukocidin positive. Eight out of nine CA-MRSA were ST30, one was ST80, and all were sensitive to co-trimoxazole and gentamicin. Five new STs designated ST1284, ST1285, ST1286, ST1287 and ST1288 were discovered, suggesting the emergence of novel clones of MRSA circulating in Malaysian hospitals. The discovery of the ST22 strain is a cause for concern because of its ability to replace existing predominant clones in certain geographical regions.
Ahmad
Norazah
N
Institute for Medical Research, Kuala Lumpur, Malaysia.
Ruzan
Izayu Nurfarha
IN
Institute for Medical Research, Kuala Lumpur, Malaysia.
Abd Ghani
Mohamed Kamel
MK
Department of Biomedical Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Hussin
Azura
A
Department of Microbiology, Queen Elizabeth Hospital, Sabah, Malaysia.
Nawi
Salbiah
S
Department of Microbiology, Selayang Hospital, Selangor, Malaysia.
Aziz
Mohamad Nazri
MN
Department of Microbiology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.
Maning
Nurahan
N
Department of Microbiology, Kota Bharu Hospital, Kelantan, Malaysia.
Eow
Victor Lim Kok
VLK
International Medical University, Kuala Lumpur, Malaysia.
D000328:Adult; D000368:Aged; D015373:Bacterial Typing Techniques; D002648:Child; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D055815:Young Adult