title: Somatosensory temporal discrimination in patients with primary focal dystonia.
abstract: OBJECTIVE
  To determine whether somatosensory temporal discrimination will reliably detect subclinical sensory impairment in patients with various forms of primary focal dystonia.
  
  
  METHODS
  The somatosensory temporal discrimination threshold (STDT) was tested in 82 outpatients affected by cranial, cervical, laryngeal and hand dystonia. Results were compared with those for 61 healthy subjects and 26 patients with hemifacial spasm, a non-dystonic disorder. STDT was tested by delivering paired stimuli starting with an interstimulus interval of 0 ms followed by a progressively increasing interstimulus interval.
  
  
  RESULTS
  STDT was abnormal in all the different forms of primary focal dystonias in all three body regions (eye, hand and neck), regardless of the distribution and severity of motor symptoms. Receiver operating characteristic curve analysis calculated in the three body regions yielded high diagnostic sensitivity and specificity for STDT abnormalities.
  
  
  CONCLUSIONS
  These results provide definitive evidence that STDT abnormalities are a generalised feature of patients with primary focal dystonias and are a valid tool for screening subclinical sensory abnormalities.
authors.affiliation: Department of Neurological Sciences, Sapienza, University of Rome, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Scontrini
authors.forename: A
authors.initials: A
authors.lastname: Conte
authors.forename: G
authors.initials: G
authors.lastname: Defazio
authors.forename: M
authors.initials: M
authors.lastname: Fiorio
authors.forename: G
authors.initials: G
authors.lastname: Fabbrini
authors.forename: A
authors.initials: A
authors.lastname: Suppa
authors.forename: M
authors.initials: M
authors.lastname: Tinazzi
authors.forename: A
authors.initials: A
authors.lastname: Berardelli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001764:Blepharospasm / Q000503:physiopathology; D004192:Discrimination, Psychological / Q000502:physiology*; D020821:Dystonic Disorders / Q000503:physiopathology*; D005260:Female; D006225:Hand / Q000503:physiopathology; D006801:Humans; D007826:Laryngismus / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D014103:Torticollis / Q000503:physiopathology; D014110:Touch / Q000502:physiology*