title: Dynamic properties of molecular motors in the divided-pathway model.
abstract: The mechanisms of molecular motors transport are important for understanding multiple biological processes. Recent single-molecule experiments indicate that motor proteins myosin V moves along protein filaments via a complex biochemical pathway that consists of sequentially coupled linear and parallel two-chain segments. We investigate analytically the corresponding discrete-state stochastic divided-pathway model for molecular motors transport. Explicit expressions are obtained for velocities and dispersions. The dynamic properties of motor proteins in the divided-pathway model are compared with those in single-chain linear and parallel-pathway stochastic models. It is argued that modifying biochemical pathways has a strong effect on the dynamic properties, and it allows motor proteins to be more flexible in performing their biological functions.
authors.affiliation: Department of Chemistry, Rice University, Houston, TX 77005, USA.
authors.forename: Rahul Kumar
authors.initials: RK
authors.lastname: Das
authors.forename: Anatoly B
authors.initials: AB
authors.lastname: Kolomeisky
mesh_terms: D007700:Kinetics; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism*; D024701:Myosin Type V / Q000378:metabolism
chemical_list: D020409:Molecular Motor Proteins; D024701:Myosin Type V