title: No association of DPP6 with amyotrophic lateral sclerosis in an Italian population.
abstract: We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.
authors.affiliation: MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, UK. I.Fogh@iop.kcl.ac.uk
authors.forename: Isabella
authors.initials: I
authors.lastname: Fogh
authors.forename: Sandra
authors.initials: S
authors.lastname: D'Alfonso
authors.forename: Cinzia
authors.initials: C
authors.lastname: Gellera
authors.forename: Antonia
authors.initials: A
authors.lastname: Ratti
authors.forename: Cristina
authors.initials: C
authors.lastname: Cereda
authors.forename: Silvana
authors.initials: S
authors.lastname: Penco
authors.forename: Lucia
authors.initials: L
authors.lastname: Corrado
authors.forename: Gianni
authors.initials: G
authors.lastname: Sorarù
authors.forename: Barbara
authors.initials: B
authors.lastname: Castellotti
authors.forename: Cinzia
authors.initials: C
authors.lastname: Tiloca
authors.forename: Stella
authors.initials: S
authors.lastname: Gagliardi
authors.forename: Lorena
authors.initials: L
authors.lastname: Cozzi
authors.forename: Michelle K
authors.initials: MK
authors.lastname: Lupton
authors.forename: Nicola
authors.initials: N
authors.lastname: Ticozzi
authors.forename: Letizia
authors.initials: L
authors.lastname: Mazzini
authors.forename: Chris E
authors.initials: CE
authors.lastname: Shaw
authors.forename: Ammar
authors.initials: A
authors.lastname: Al-Chalabi
authors.forename: John
authors.initials: J
authors.lastname: Powell
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Silani
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D015331:Cohort Studies; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007558:Italy; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015221:Potassium Channels / Q000235:genetics*
chemical_list: D009419:Nerve Tissue Proteins; D015221:Potassium Channels; C503535:DPP6 protein, human; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases