title: Anticoagulant effects of a complex of high molecular weight heparin and arginine.
abstract: Heparin forms a complex compound with arginine in a pure system, which was shown by biochemical methods. A method for obtaining the complex in vitro has been developed. At arginine/heparin molar ratio of 3:1 the complex exhibited anticoagulant, antiplatelet, and fibrin-depolymerization activities. High fibrin-depolymerization and anticoagulant activities were documented in the blood of animals 10 min after intravenous injection of the arginine-heparin complex, in contrast to the picture after injection of the complex components (heparin and arginine) alone.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov State Moscow University, Russia. lyapinal@mail.ru
authors.forename: L A
authors.initials: LA
authors.lastname: Lyapina
authors.forename: T Yu
authors.initials: TY
authors.lastname: Obergan
authors.forename: V E
authors.initials: VE
authors.lastname: Pastorova
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001120:Arginine / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005337:Fibrin / Q000737:chemistry / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D006493:Heparin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D008970:Molecular Weight; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D005337:Fibrin; D006493:Heparin; D001120:Arginine