Abnormalities in the membrane material properties of hereditary spherocytes.
Mechanical measurements of intrinsic membrane material properties are used to characterize the defect in hereditary spherocyte membrane at a continuum level. The value of the surface elastic shear modulus is two-thirds as large as normal values, and the value of the yield shear resultant is one-third as large as normal values. The viscosity of the surface above the elastic-plastic transition appears normal. Under similar geometric conditions, the force required to fragment a hereditary spherocyte is about one-third as large as the force required to fragment a normal cell.
Waugh
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Department of Radiation Biology and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, N.Y. 14642, USA.
La Celle
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D003198:Computer Simulation; D055119:Elastic Modulus; D004910:Erythrocyte Membrane / Q000473:pathology*; D006801:Humans; D008955:Models, Cardiovascular; D033081:Shear Strength; D013103:Spherocytosis, Hereditary / Q000473:pathology* / Q000503:physiopathology*; D013314:Stress, Mechanical; D014783:Viscosity