[Expression of THY1 gene in epithelial ovarian cancer].
OBJECTIVE
To detect the expession of THY1 in ovarian serous cystadenocarcinoma tissues.


METHODS
Immunohistochemistry was performed to detect the expression of THY1 gene in formalin-fixed, paraffin-embedded specimens of normal ovaries (n = 25), ovarian serous cystadenoma (n = 25), and serous cystadenocarcinoma (n = 53). The correlation of THY1 expression with clinicopathological parameters was statistically analyzed.


RESULTS
The positive expression rates of THY1 protein in normal ovaries, ovarian serous cystadenomas and ovarian serous cystadenocarcinomas were 60.0% (15/25), 72.0% (18/25) and 34.0% (18/53), respectively. The values of IOD of THY1 protein expression were 288,449.2 +/- 60,087.3, 271,655.6 +/- 66,588.7 and 252,087.6 +/- 45,559.4, respectively. The expression of THY1 protein was significantly down-regulated in ovarian serous cystadenocarcinoma tissues compared with that in normal ovarian tissues and ovarian serous cystadenoma tissues (P < 0.05). THY1 expression was negatively correlated with surgical-pathological staging, histological differentiation and lymph node involvement (P < 0.05).


CONCLUSIONS
The decreased level of THY1 expression may be related with the occurrence and development of ovarian serous cystadenocarcinoma.
Zeng
Li-qin
LQ
Department of Gynecology, Guangdong Women's and Children's Hospital and Health Institute, Guangzhou 510010, China. zenglq89@163.com
Peng
Zhi-lan
ZL
Duan
Zhen-ling
ZL
D000328:Adult; D000368:Aged; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism* / Q000473:pathology; D018293:Cystadenoma, Serous / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D018800:Thy-1 Antigens / Q000378:metabolism*; D055815:Young Adult
D018800:Thy-1 Antigens