Recent developments in thrombin-activatable fibrinolysis inhibitor research.
Thrombin-activatable fibrinolysis inhibitor (TAFI) provides an important molecular link between the coagulation and fibrinolytic systems. In this review, recent major advances in TAFI research, including the elucidation of crystal structures, the development of small inhibitors and the role of TAFI in systems other than hemostasis, are described and discussed.
Marx
Pauline F
PF
Department of Experimental Vascular Medicine, G1-145, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. p.f.marx@amc.uva.nl
Verkleij
Chantal J N
CJ
Valls Seron
Mercedes
M
Meijers
Joost C M
JC
D000818:Animals; D025901:Carboxypeptidase B2 / Q000737:chemistry / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D008958:Models, Molecular
D025901:Carboxypeptidase B2