Synthesis of the tetracyclic core of the neomangicols using a late-stage indene alkylation.
A general approach to the tetracyclic core of the neomangicol natural products via a late-stage indene alkylation reaction is presented. This strategy sets the stage for access to the neomangicol family and, in addition, provides a potential biogenetically inspired entry to the mangicol natural products.
Wood
Jessica L
JL
Department of Chemistry, University of California, Berkeley, California 94720, USA.
Pujanauski
Brian G
BG
Sarpong
Richmond
R
D000478:Alkylation; D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007192:Indenes / Q000737:chemistry*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry
D001685:Biological Factors; D007192:Indenes; D012717:Sesquiterpenes; C542716:neomangicol C; C093581:indene