Mitotic division of the mammalian Golgi apparatus.
Successful cell reproduction requires faithful duplication and proper segregation of cellular contents, including not only the genome but also intracellular organelles. Since the Golgi apparatus is an essential organelle of the secretory pathway, its accurate inheritance is therefore of importance to sustain cellular function. Regulation of Golgi division and its coordination with cell cycle progression involves a series of sequential events that are subjected to a precise spatiotemporal control. Here, we summarize the current knowledge about the underlying mechanisms, the molecular players and the biological relevance of this process, particularly in mammalian cells, and discuss the unsolved problems and future perspectives opened by the recent studies.
Wei
Jen-Hsuan
JH
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Seemann
Joachim
J
D000818:Animals; D004721:Endoplasmic Reticulum; D006056:Golgi Apparatus; D006801:Humans; D008322:Mammals; D008938:Mitosis; D008941:Spindle Apparatus