title: Successful mobilization of peripheral blood stem cells with bortezomib + high-dose cyclophosphamide + G-CSF in a light chain myeloma patient after failure with Total Therapy 2.
abstract: Autologous stem cell transplantation is considered the best post-induction therapy for multiple myeloma (MM). Therefore, therapy for myeloma should be chosen not only on the basis of efficacy, but also taking into account their impact on the hematopoietic stem cell compartment. We describe the case of a MM patient in which a successful mobilization of peripheral stem cells was obtained with bortezomib, cyclophosphamide and G-CSF, after two failed attempts in the framework of Total Therapy 2. The patient underwent an autologous transplantation, showing a rapid and complete post-transplant hematological recovery. Our experience suggests that bortezomib is an effective anti-myeloma agent without negative impact on stem cell mobilization, even in patients with a previous history of failed harvest.
authors.affiliation: Oncology Regional Department, Oncology and Hematology Units, "A.Cardarelli" Hospital, C.da Tappino, 86100, Campobasso, Italy. gianfrancogiglio@alice.it.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Giglio
authors.affiliation: Oncology Regional Department, Oncology and Hematology Units, "A.Cardarelli" Hospital, C.da Tappino, 86100, Campobasso, Italy.
authors.forename: Sante
authors.initials: S
authors.lastname: Romito
authors.affiliation: Oncology Regional Department, Oncology and Hematology Units, "A.Cardarelli" Hospital, C.da Tappino, 86100, Campobasso, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Carrozza
authors.affiliation: Oncology Regional Department, Oncology and Hematology Units, "A.Cardarelli" Hospital, C.da Tappino, 86100, Campobasso, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Musacchio
authors.affiliation: Oncology Regional Department, Oncology and Hematology Units, "A.Cardarelli" Hospital, C.da Tappino, 86100, Campobasso, Italy.
authors.forename: Giustino
authors.initials: G
authors.lastname: Antuzzi
authors.affiliation: Laboratory Medicine Unit, "A.Cardarelli" Hospital, Campobasso, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Gigli
authors.affiliation: Laboratory Medicine Unit, "A.Cardarelli" Hospital, Campobasso, Italy.
authors.forename: Marilù
authors.initials: M
authors.lastname: Magri
authors.affiliation: Department of Hematology, Hematological Intensive Care for Hematopoietic Transplantation Unit, Pescara Hospital, Pescara, Italy.
authors.forename: Pasqua
authors.initials: P
authors.lastname: Bavaro
authors.affiliation: Department of Hematology, Hematological Intensive Care for Hematopoietic Transplantation Unit, Pescara Hospital, Pescara, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Di Bartolomeo
authors.affiliation: Department of Transfusional Medicine, Apheresis Unit, Pescara Hospital, Pescara, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Dell'Isola
authors.affiliation: Department of Transfusional Medicine, Apheresis Unit, Pescara Hospital, Pescara, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Accorsi
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D001897:Boronic Acids / Q000008:administration & dosage*; D000069286:Bortezomib; D003520:Cyclophosphamide / Q000008:administration & dosage*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D007147:Immunoglobulin Light Chains; D008297:Male; D009101:Multiple Myeloma / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D011719:Pyrazines / Q000008:administration & dosage*; D014182:Transplantation, Autologous
chemical_list: D018906:Antineoplastic Agents, Alkylating; D001897:Boronic Acids; D007147:Immunoglobulin Light Chains; D011719:Pyrazines; D016179:Granulocyte Colony-Stimulating Factor; D000069286:Bortezomib; D003520:Cyclophosphamide