[Tumoral angiogenesis: models, targets and inhibition].
Angiogenesis is a basic process during development and in pathology as well. The molecular networks involved in angiogenesis are not totally understood. We have recently developed a new model for tumoral angiogenesis in the chicken embryo, which allows large scale studies. On the other hand we have uncovered a new induction pathway, which involves stress of the endoplasmic reticulum. These investigations open up novel prospects for the future.
Bikfalvi
Andreas
A
LMMA et INSERM U 920, Université Bordeaux I, Avenue des Facultés, 33405 Talence, France. a.bikfalvi@angio.u-bordeaux1.fr
D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D015687:Cell Hypoxia / Q000235:genetics; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply*; D004721:Endoplasmic Reticulum / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000235:genetics*; D056811:Unfolded Protein Response / Q000187:drug effects / Q000502:physiology
D020533:Angiogenesis Inhibitors; D051795:Hypoxia-Inducible Factor 1, alpha Subunit