title: Persistent deficits in heart rate response habituation following neonatal binge ethanol exposure.
abstract: BACKGROUND
  We have previously shown that the rate of habituation of the heart rate orienting response to a novel odor in rats is negatively affected by neonatal ethanol exposure. Thus far, however, only young rats (16 days of age) have been tested. Given the persistence of attention and memory problems evident in humans exposed to ethanol in utero, the purpose of this experiment was to examine the longer-term consequences of ethanol exposure on response habituation.
  
  
  METHODS
  Ethanol (5.25 g/kg/d) was administered intragastrically to male and female Sprague-Dawley rats on postnatal days (PD) 4 to 9, and controls were given sham intubations. Animals were tested for heart rate orienting and response habituation to a novel olfactory stimulus (amyl acetate) on PD 16, 23, or 30.
  
  
  RESULTS
  Animals tested on PD 16 or 23 showed normal heart rate deceleration to the novel odor, a measure of the orienting response. However, ethanol-treated subjects showed impaired response habituation compared with sham controls. While controls exhibited complete habituation within 4 to 5 trials, ethanol-treated animals continued to respond throughout the testing session, with little decrement in heart rate response magnitude across 10 stimulus presentations. A different pattern of responding was observed in animals tested during adolescence (PD 30). Control animals failed to show the typical heart rate decrease indicative of orienting, and instead showed a tendency toward tachycardia. In contrast, ethanol-treated animals tested on PD 30 showed orienting bradycardia that persisted for several trials.
  
  
  CONCLUSIONS
  These data suggest that there are relatively long-term consequences of neonatal ethanol exposure on nonassociative memory. This impairment in habituation may be relevant to the distractibility and poor focused attention that is pervasive among humans diagnosed with fetal alcohol spectrum disorders.
authors.affiliation: Department of Psychology, College of William and Mary, Williamsburg, VA 23187-8795, USA.
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Morasch
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Hunt
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001288:Attention / Q000187:drug effects; D001835:Body Weight / Q000502:physiology; D002492:Central Nervous System Depressants / Q000633:toxicity*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D006339:Heart Rate / Q000502:physiology*; D008297:Male; D008568:Memory / Q000187:drug effects; D000439:Pentanols; D051381:Rats; D017207:Rats, Sprague-Dawley; D012903:Smell / Q000187:drug effects / Q000502:physiology
chemical_list: D002492:Central Nervous System Depressants; D000439:Pentanols; D000431:Ethanol; C005716:amyl acetate