[24-hours monitoring of ECG and glucose level for detection of relations between glycemia and QT interval duration in patients with type 1 diabetes].
OBJECTIVE
To study correlations between glycemia and duration of ventricular repolarization in children and adolescents with type 1 diabetes mellitus (DM).


METHODS
Parallel monitoring of ECG and glycemia was conducted in 43 type 1 MD patients (age 7-17 years, 12.8 +/- 2.7) and 37 healthy children and adolescents.


RESULTS
Glycemia under 3 mmol/l and over 19 mmol/l is associated with significantly longer QTc interval compare to other blood glucose levels (437 ms and 447 ms versus 430 ms, p < 0.01). Also, in these glycemia values QTc interval duration over 440 ms (46 and 62% versus 33%; p < 0.01) becomes more frequent. In healthy children and adolescents mean duration and frequency of a longer QTc interval were significantly less than in diabetic patients irrespective of glycemia degree in patients with type 1 DM (p < 0.01). A moderate correlation was found between a daily insulin dose and QTc duration (correlation coefficient 0.35, p = 0.02).


CONCLUSIONS
Glycemia under 3 mmol/l and over 19 mmol/l can prolong QT interval and, therefore, raise the risk of cardiovascular death in patients with type 1 DM.
Laptev
D N
DN
Riabykina
G V
GV
Seid-Guseĭnov
A A
AA
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D015716:Electrocardiography, Ambulatory; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D007003:Hypoglycemia / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D008133:Long QT Syndrome / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D008297:Male
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin