Genetic variants in immunoregulatory genes and risk for childhood lymphomas.
To investigate whether single nucleotide polymorphisms (SNPs) in key cytokine and innate immunity genes influence risk for childhood lymphomas, we genotyped 37 children with Hodgkin's (HL) and 48 with non-Hodgkin's lymphoma (NHL), aged (1 month-14 yr), along with their 85 age- and gender-matched controls suffering from mild medical conditions. Genotypic analysis was performed for 10 SNPs from nine genes with important role in immunoregulatory pathways (IL4, IL4R, IL6, IL10, IL12, IL18, TNFalpha, IFNgamma, CD14). Analysis of SNPs genotypes revealed that the CD14 -159 C>T polymorphism was associated with significantly increased risk for HL regarding both the CC and CT genotypes (OR(CC): 5.36; 95% CI, 1.30-22.14; P = 0.02, OR(CT): 3.76; 95% CI, 1.00-14.16; P = 0.05). An indicative association between IL18-137 G>C polymorphism with the CC genotype and NHL did not reach, however, statistical significance (OR(CC), 3.78; 95% CI, 0.87-16.38; P = 0.08). In conclusion, our findings suggest that genetic variation in the CD14-159 loci may be associated with childhood HL risk; these preliminary findings need to be further confirmed in sizeable multi-centre studies along with determination of cytokines, which could provide an insight on the biologic basis underlying these findings.
Andrie
Elisabeth
E
Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, 75 Mikras Asias Str., Goudi, Athens, Greece.
Michos
Athanasios
A
Kalampoki
Vassiliki
V
Pourtsidis
Apostolos
A
Moschovi
Maria
M
Polychronopoulou
Sophia
S
Athanasiadou-Piperopoulou
Fani
F
Kalmanti
Maria
M
Hatzakis
Angelos
A
Paraskevis
Dimitrios
D
Nieters
Alexandra
A
Petridou
Eleni Th
ET
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005838:Genotype; D006689:Hodgkin Disease; D006801:Humans; D007109:Immunity / Q000235:genetics*; D007223:Infant; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics* / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin; D020641:Polymorphism, Single Nucleotide; D012306:Risk
D018950:Lipopolysaccharide Receptors