title: HIV screening reactivity due to donor participation in HIV vaccine trials.
abstract: We report two instances of human immunodeficiency virus (HIV) serological screening reactivity in blood donations which were subsequently determined to be due to donor participation in HIV vaccine trials. Both donations were screen reactive with atypical patterns on confirmation; no definitive conclusion could be given for either donor. Subsequent questioning identified that both donors had been involved in HIV vaccine trials. In both cases the screening and confirmation identified the presence of HIV antibodies, although vaccine induced. While clinical trials of vaccines are important, the implications of some need careful consideration if they are not to adversely impact other areas of healthcare.
authors.affiliation: National Transfusion Microbiology Reference Laboratory, NHS Blood and Transplant, National Blood Service, Colindale Avenue, London, UK. alan.kitchen@nhsbt.nhs.uk
authors.forename: A D
authors.initials: AD
authors.lastname: Kitchen
authors.forename: P E
authors.initials: PE
authors.lastname: Hewitt
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000328:Adult; D001782:Blood Donors; D003951:Diagnostic Errors; D005260:Female; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000175:diagnosis* / Q000635:transmission; D006801:Humans; D008403:Mass Screening; D065227:Transfusion Reaction
chemical_list: D016915:AIDS Vaccines; D015483:HIV Antibodies