title: Correlation between single nucleotide polymorphism of prothrombin gene G20210 and deep vein thrombosis after total joint replacement in Chinese patients.
abstract: OBJECTIVE
  To evaluate the correlation between prothrombin gene G20210A mutation and deep vein thrombosis after total joint replacement through detecting distribution frequency of single nucleotide polymorphism of the gene in patients undergoing total joint replacement.
  
  
  METHODS
  PCR and direct sequencing of DNA are used to analyze the frequency of prothrombin gene G20210A mutation in 55 patients undergoing total joint replacement, and the relationship between the mutation and deep vein thrombosis after total joint replacement is evaluated.
  
  
  RESULTS
  Morbidity of prothrombin gene G20210A mutation in 55 patients is 0, both in the DVT group and non-DVT group. There is no significant difference between the two groups (p > 0.05).
  
  
  CONCLUSIONS
  Mutation of prothrombin gene G20210A in Chinese patients is rare, and there is no correlation between the genetic mutation and deep vein thrombosis after total joint replacement.
authors.affiliation: Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Jun
authors.forename: Zhenpeng
authors.initials: Z
authors.lastname: Guan
authors.forename: Zhang
authors.initials: Z
authors.lastname: Zhuo
authors.forename: L V
authors.initials: LV
authors.lastname: Housshan
mesh_terms: D000328:Adult; D000368:Aged; D019643:Arthroplasty, Replacement / Q000009:adverse effects*; D044466:Asian People / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011516:Prothrombin / Q000235:genetics*; D020246:Venous Thrombosis / Q000209:etiology* / Q000235:genetics*
chemical_list: D011516:Prothrombin