Periodontitis and type 2 diabetes: is oxidative stress the mechanistic link?
Periodontitis is a common, chronic inflammatory disease initiated by bacteria which has an increased prevalence and severity in patients with type 2 diabetes. Recent studies indicate that the co-morbid presence of periodontitis can, in turn, adversely affect diabetic status and the treatment of periodontitis can lead to improved metabolic control in diabetes patients. Current evidence points to a bidirectional interrelationship between diabetes and inflammatory periodontitis. The importance of oxidative stress-inflammatory pathways in the pathogenesis of type 2 diabetes and periodontitis has recently received attention. Given the bidirectional relationship between these two conditions, this review discusses the potential synergistic interactions along the oxidative stress-inflammation axis common to both type 2 diabetes and periodontitis, and the implications of this relationship for diabetic patients.
Allen
E M
EM
Dept. of Restorative Dentistry, Cork University Dental School & Hospital, Cork, Ireland. e.allen@ucc.ie
Matthews
J B
JB
O'Connor
R
R
O'Halloran
D
D
Chapple
I L C
IL
D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D010518:Periodontitis / Q000150:complications* / Q000378:metabolism / Q000473:pathology