Wireless capsule endoscopy for the detection of small bowel diseases in HIV-1-infected patients.
OBJECTIVE
In HIV-infected patients, manifestations of the disease are common in the gastrointestinal tract. The objective of our study was to evaluate the diagnostic yield of the Given(R) Video Capsule System (Given Imaging, Yoqneam, Israel) in these patients.


METHODS
After the exclusion of GI-tract stenosis by anamnestic exploration, 49 patients were included into the study. Stratification: Group A (n = 19): HIV-positive, CD4 cell count < 200/microl, gastrointestinal symptoms present. Group B: HIV-positive, CD subset4 < 200/microl, without gastrointestinal symptoms (n = 19 Group) C: healthy volunteers (n = 11).


RESULTS
In group A there was a total of 30 pathological findings, 15 of which had therapeutic implications. In group B, there was a total of 22 pathological findings, 5 relevant for therapy. In group C there was a total of 13 pathological findings, 3 with therapeutic relevance. In 89% (group A) vs. 26% (group B), pathological findings were detected distal to the ligament of Treitz (p = 0.001). All capsules were recovered without any complication after 12 to 96 h from the stool.


CONCLUSIONS
Wireless capsule endoscopy of the small intestine should be considered for HIV-infected patients with marked immunosuppression and gastrointestinal symptoms.
Oette
Mark
M
Klinik für Allgemeine Innere Medizin, Gastroenterologie und Infektiologie, Krankenhaus der Augustinerinnen, Jakobstr. 27-31, 50678 Köln, Germany. m.oette@koeln-kh-augustinerinnen.de
Stelzer
A
A
Göbels
K
K
Wettstein
M
M
Sagir
A
A
Feldt
T
T
Häussinger
D
D
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000473:pathology*; D015746:Abdominal Pain / Q000175:diagnosis / Q000209:etiology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology*; D000328:Adult; D053704:Capsule Endoscopy / Q000379:methods*; D003967:Diarrhea / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007410:Intestinal Diseases / Q000150:complications / Q000175:diagnosis*; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies