title: Disappearance of vaccine-type invasive pneumococcal disease and emergence of serotype 19A in a minority population with a high prevalence of human immunodeficiency virus and low childhood immunization rates.
abstract: We analyzed the epidemiology of invasive pneumococcal disease (IPD) following introduction of pneumococcal conjugated vaccine in an urban population with a 2% human immunodeficiency virus (HIV) prevalence and history of low childhood immunization rates. We observed near-elimination of vaccine-type IPD. Substantial disease remains due to non-vaccine-type pneumococci, highlighting the need to increase pneumococcal immunization among HIV-infected adults.
authors.affiliation: Department of Preventive Medicine and Community Health, New Jersey Medical School-UMDNJ, MSB F594, Newark, NJ 07103, USA.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Tasslimi
authors.forename: Erica J
authors.initials: EJ
authors.lastname: Sison
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Story
authors.forename: David
authors.initials: D
authors.lastname: Alland
authors.forename: Michele
authors.initials: M
authors.lastname: Burday
authors.forename: Susan
authors.initials: S
authors.lastname: Morrison
authors.forename: Sandhya
authors.initials: S
authors.lastname: Nalmas
authors.forename: Stephen
authors.initials: S
authors.lastname: Smith
authors.forename: Pauline A
authors.initials: PA
authors.lastname: Thomas
authors.forename: Peter
authors.initials: P
authors.lastname: Wenger
authors.forename: Anushua
authors.initials: A
authors.lastname: Sinha
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D015995:Prevalence; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification*; D014481:United States; D014505:Urban Population; D055815:Young Adult
chemical_list: D022242:Pneumococcal Vaccines