title: Imaging of optic nerve head drusen: improvements with spectral domain optical coherence tomography.
abstract: OBJECTIVE
  To demonstrate a new algorithm that can determine the shape, location, and volume of optic nerve head drusen (ONHD), which were imaged with spectral domain optical coherence tomography (SDOCT).
  
  
  METHODS
  One exenteration patient and 4 glaucoma patients with bilateral ONHD were recruited from the Massachusetts Eye and Ear Infirmary and from a private practice office. Images were obtained using an experimental SDOCT system developed at the Wellman Center for Photomedicine, Massachusetts General Hospital. With axial resolutions of about 6 mum, SDOCT can obtain 2-dimensional images in 1/29 of a second, compared with commercially available time domain OCT instruments with 10 mum resolution images in 1.28 seconds. The volumes of ONHD were calculated with a new algorithm and were then correlated with visual field mean deviation.
  
  
  RESULTS
  SDOCT can display 2-dimensional images comparable with histology and 3-dimensional videos of ONHD. ONHD are signal-poor regions with high-signaled borders. Larger ONHD volumes are directly correlated with larger mean deviation absolute values on Humphrey visual field testing.
  
  
  CONCLUSIONS
  SDOCT is a potentially better technique for ONHD imaging and may improve the diagnosis and management of patients with both OHND and glaucoma.
authors.affiliation: Harvard Medical School, Department of Ophthalmology, Glaucoma Service, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Kayoung
authors.initials: K
authors.lastname: Yi
authors.forename: Mircea
authors.initials: M
authors.lastname: Mujat
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Daina
authors.initials: D
authors.lastname: Burnes
authors.forename: Mark A
authors.initials: MA
authors.lastname: Latina
authors.forename: Derrick T
authors.initials: DT
authors.lastname: Lin
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Deschler
authors.forename: Peter A D
authors.initials: PA
authors.lastname: Rubin
authors.forename: Boris Hyle
authors.initials: BH
authors.lastname: Park
authors.forename: Johannes F
authors.initials: JF
authors.lastname: de Boer
authors.forename: Teresa C
authors.initials: TC
authors.lastname: Chen
mesh_terms: D000368:Aged; D000465:Algorithms; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D015594:Optic Disk Drusen / Q000150:complications / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000592:standards; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology; D058609:Visual Field Tests / Q000379:methods; D014794:Visual Fields