title: The spectrum of structural abnormalities on CT scans from patients with CF with severe advanced lung disease.
abstract: BACKGROUND
  In cystic fibrosis (CF), lung disease is the predominant cause of morbidity and mortality. Little is known about the spectrum of structural abnormalities on CT scans from patients with CF with severe advanced lung disease (SALD). No specific CT scoring system for SALD is available.
  
  
  OBJECTIVE
  To design a quantitative CT scoring system for SALD, to determine the spectrum of structural abnormalities in patients with SALD and to correlate the SALD system with an existing scoring system for mild CF lung disease and pulmonary function tests (PFTs).
  
  
  METHODS
  57 patients with CF contributed one CT made during screening for lung transplantation. For the SALD system, lung tissue was divided into four components: infection/inflammation (including bronchiectasis, airway wall thickening, mucus and consolidations), air trapping/hypoperfusion, bulla/cysts and normal/hyperperfused tissue. The volume proportion of the components was estimated on a 0-100% scale; mean volumes for the whole lung were computed. Scores were correlated with Brody-II scores and PFTs.
  
  
  RESULTS
  The SALD system identified a wide spectrum of structural abnormalities ranging from predominantly infection/inflammation to predominantly air trapping/hypoperfusion. SALD infection/inflammation scores correlated with Brody-II scores (r(s) = 0.36-0.64) and SALD normal/hyperperfusion scores correlated with forced expiratory volume in 1 s (FEV(1); r(s) = 0.37). Reproducibility for both systems was good.
  
  
  CONCLUSIONS
  A CT scoring system was developed to characterise the structural abnormalities in patients with SALD. A wide spectrum was observed in SALD, ranging from predominantly air trapping to predominantly infection/inflammation-related changes. This spectrum may have clinical implications for patients with SALD.
authors.affiliation: Department of Pediatric Pulmonology & Allergology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Loeve
authors.forename: P Th W
authors.initials: PT
authors.lastname: van Hal
authors.forename: P
authors.initials: P
authors.lastname: Robinson
authors.forename: P A
authors.initials: PA
authors.lastname: de Jong
authors.forename: M H
authors.initials: MH
authors.lastname: Lequin
authors.forename: W C
authors.initials: WC
authors.lastname: Hop
authors.forename: T J
authors.initials: TJ
authors.lastname: Williams
authors.forename: G D
authors.initials: GD
authors.lastname: Nossent
authors.forename: H A
authors.initials: HA
authors.lastname: Tiddens
mesh_terms: D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D015588:Observer Variation; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014797:Vital Capacity / Q000502:physiology; D055815:Young Adult