Effect of antioxidant therapy on glutathione system of erythrocytes in chronic brain ischemia.
We studied the effect of antioxidant therapy on the state of glutathione system in erythrocytes in patients with stage 1, 2, and 3 circulatory encephalopathy treated with antioxidant cytoflavin against the background of basic therapy (kavinton and pyracetam). It was demonstrated that the response of the erythrocyte glutathione system to antioxidant therapy was quantitatively and qualitatively different at different stages of cerebrovascular failure, which was related to changes in the glutathione system during the development of chronic cerebral ischemia. Endogenous reserve of the antioxidant defense system should be taken into account when prescribing antioxidant therapy; the glutathione system can be a marker of this reserve.
Antipenko
E A
EA
Department of Neurology, Nizhnii Novgorod State Medical Academy, Nizhnii Novgorod, Russia.
Gustov
A V
AV
Davydova
K S
KS
Krylova
E V
EV
D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism; D002908:Chronic Disease; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D000975:Antioxidants; D005978:Glutathione