title: [Case of thalidomide-induced interstitial pneumonia].
abstract: A 68-year-old man with multiple myeloma was admitted to our hospital complaining of slight fever and dyspnea on effort 4 months after treatment with thalidomide. Chest HRCT findings showed diffuse ground-glass attenuation, small nodules, and interlobular septal thickening in bilateral lungs. BAL showed marked lymphocytosis, and TBLB revealed alveolitis with exudative change, consistent with drug-induced interstitial pneumonitis. His thalidomide treatment was withdrawn and his symptoms and HRCT findings improved. Therefore, we diagnosed thalidomide-induced interstitial pneumonitis. Thalidomide-induced interstitial pneumonitis is rare, and only 4 cases have been reported in the literature. We concluded that we should consider thalidomide-induced interstitial pneumonitis in cases with multiple myeloma following thalidomide treatment.
authors.affiliation: The Department of Respiratory Medicine, Saitama Red Cross Hospital.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Matsushima
authors.forename: Toshimi
authors.initials: T
authors.lastname: Oda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Sato
authors.forename: Nobuchika
authors.initials: N
authors.lastname: Hasejima
authors.forename: Shinji
authors.initials: S
authors.lastname: Takezawa
mesh_terms: D000368:Aged; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy; D013792:Thalidomide / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D013792:Thalidomide