title: [Review of 32 gastro-intestinal stromal tumours with CD117 antigen].
abstract: OBJECTIVE
  The aim of this study is to review clinical data, histological and immunohistochemical findings and prognosis of stromal gastrointestinal tumors.
  
  
  METHODS
  A retrospective Study of 32 cases of stromal gastrointestinal tumors diagnosed in the Department of Pathology of Mongi Slim Hospital of Tunis from 1991 to 2004.
  
  
  RESULTS
  The average age of the patients was of 54.4 years, equal for sex. Tumors were essentially gastric (50%) and of the small intestine (37.5%). All the patients had surgical treatment. Gastro-intestinal Stromal Tumors or GIST represent the most frequent stromal tumor with 56.2% of cases.
  
  
  CONCLUSIONS
  After immunohistochimestry study, using CD117 antigen, this revision allows better management of GIST. Glivec is the standard treatment of advanced GIST.
authors.affiliation: Service d'Anatomie Pathologique, Hôpital Mongi Slim, La Marsa, Tunisie.
authors.forename: Ahlem
authors.initials: A
authors.lastname: Lahmar-Boufaroua
authors.forename: Sana
authors.initials: S
authors.lastname: Ben Slama
authors.forename: Saadia
authors.initials: S
authors.lastname: Bouraoui
authors.forename: Lassaad
authors.initials: L
authors.lastname: Gharbi
authors.forename: Carole
authors.initials: C
authors.lastname: Goutallier
authors.forename: Saber
authors.initials: S
authors.lastname: Manai
authors.forename: Walid
authors.initials: W
authors.lastname: Gharbi
authors.forename: Sabah
authors.initials: S
authors.lastname: Mzabi-Regaya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D014408:Biomarkers, Tumor / Q000378:metabolism*; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D007078:Ileal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D000068877:Imatinib Mesylate; D007580:Jejunal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D011743:Pyrimidines / Q000627:therapeutic use; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D014408:Biomarkers, Tumor; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit