title: Conjugated linoleic acid prevents cell growth and cytokine production induced by TPA in human keratinocytes NCTC 2544.
abstract: Conjugated linoleic acid (CLA) is reported to have anti-cancer activity, based on animal and in vitro studies. Since it has been suggested that CLA anti-carcinogenic effect stems from its anti-inflammatory properties, this study investigated whether CLA can prevent cell proliferation induced by TPA in human keratinocytes NCTC 2544 contemporary to inhibition of inflammation. Results obtained showed that CLA prevents increased cell proliferation and production of pro-inflammatory molecules determined by TPA, being this effect due to modulation of PPARs and NFkB activity. The involvement of PPARalpha in CLA effect was demonstrated by adding to the cells an antagonist of PPARalpha.
authors.affiliation: Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Corso Raffaello 30, 10125 Torino, Italy.
authors.forename: Germana
authors.initials: G
authors.lastname: Martinasso
authors.forename: Silvia
authors.initials: S
authors.lastname: Saracino
authors.forename: Marina
authors.initials: M
authors.lastname: Maggiora
authors.forename: Manuela
authors.initials: M
authors.lastname: Oraldi
authors.forename: Rosa A
authors.initials: RA
authors.lastname: Canuto
authors.forename: Giuliana
authors.initials: G
authors.lastname: Muzio
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D004247:DNA / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects*; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology*; D016328:NF-kappa B / Q000378:metabolism; D047493:PPAR alpha / Q000037:antagonists & inhibitors / Q000502:physiology; D048068:PPAR-beta / Q000502:physiology; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
chemical_list: D016207:Cytokines; D044243:Linoleic Acids, Conjugated; D016328:NF-kappa B; D047493:PPAR alpha; D048068:PPAR-beta; D004247:DNA; D013755:Tetradecanoylphorbol Acetate