Nasal administration of ondansetron using a novel microspheres delivery system.
Gellan gum microspheres of ondansetron hydrochloride, for intranasal delivery, were prepared to avoid the first pass metabolism as an alternative therapy to parentral, and to improve therapeutic efficiency in treatment of nausea and vomiting. The microspheres were prepared using conventional spray-drying method. The microspheres were evaluated for characteristics like particle size, incorporation efficiency, swelling ability, zeta potential, in-vitro mucoadhesion, thermal analysis, XRD study and in-vitro drug release. Treatment of in-vitro data to different kinetic equations indicated diffusion controlled drug delivery from gellan gum microspheres. The results of DSC and XRD studies revealed molecular amorphous dispersion of ondansetron into the gellan gum microspheres.
Mahajan
Hitendra S
HS
Pharmaceutics Department, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India. hsmahajan@rediffmail.com
Gattani
Surendra G
SG
D000268:Adhesiveness; D000281:Administration, Intranasal; D000818:Animals; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D008863:Microspheres; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D017294:Ondansetron / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D010316:Particle Size; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000737:chemistry*; D012702:Serotonin Antagonists / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D012756:Sheep; D055672:Static Electricity; D013499:Surface Properties; D014961:X-Ray Diffraction
D004337:Drug Carriers; D011135:Polysaccharides, Bacterial; D012702:Serotonin Antagonists; D017294:Ondansetron; C048288:gellan gum