title: In vivo mouse studies with bioluminescence tomography.
abstract: Bioluminescence tomography (BLT) is a new molecular imaging mode, which is being actively developed to reveal molecular and cellular signatures as labeled by bioluminescent probes in a living small animal. This technology can help diagnose diseases, evaluate therapies, and facilitate drug development with mouse models. In this paper, we describe in vivo mouse experiments with BLT, and propose the reconstruction procedure of bioluminescent sources from optical data measured on the body surface of the mouse using a modality fusion approach. The results show the feasibility of our methodology for localization and quantification of the bioluminescent activities in vivo.
authors.forename: Ge
authors.initials: G
authors.lastname: Wang
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Cong
authors.forename: Kumar
authors.initials: K
authors.lastname: Durairaj
authors.forename: Xin
authors.initials: X
authors.lastname: Qian
authors.forename: Haiou
authors.initials: H
authors.lastname: Shen
authors.forename: Patrick
authors.initials: P
authors.lastname: Sinn
authors.forename: Eric
authors.initials: E
authors.lastname: Hoffman
authors.forename: Geoffrey
authors.initials: G
authors.lastname: McLennan
authors.forename: Michael
authors.initials: M
authors.lastname: Henry