Activity of sphingomyelinase in rat liver in acute and chronic toxic hepatitis: proportion between peroxidative and phospholipase pathways of lipid bilayer modification.
We showed that sphingomyelinase activity in the liver increased only during the acute phase of toxic hepatitis. Peroxidative modification of hepatocyte membrane bilayer prevailed during the acute phase, while after transformation of the process to the chronic phase phospholipase pathway predominated.
Serebrov
V Yu
VY
Department of Biochemistry and Molecular Biology, Siberian State Medical University, Tomsk, Russia. serebrov@ssmu.ru
Kuzmenko
D I
DI
Burov
P G
PG
Novitsky
S V
SV
D000208:Acute Disease; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000378:metabolism; D002908:Chronic Disease; D008051:Lipid Bilayers; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D010739:Phospholipase D / Q000378:metabolism*; D054467:Phospholipases A2 / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism*
D008051:Lipid Bilayers; D054467:Phospholipases A2; D013108:Sphingomyelin Phosphodiesterase; D010739:Phospholipase D