Influence of exercise mode and osteogenic index on bone biomarker responses during short-term physical training.
Prescribing exercise based on intensity, frequency, and duration of loading may maximize osteogenic responses in bone, but a model of the osteogenic potential of exercise has not been established in humans. In rodents, an osteogenic index (OI) has been used to predict the osteogenic potential of exercise. The current study sought to determine whether aerobic, resistance, or combined aerobic and resistance exercise programs conducted over eight weeks and compared to a control group could produce changes in biochemical markers of bone turnover indicative of bone formation. We further sought to determine whether an OI could be calculated for each of these programs that would reflect observed biochemical changes. We collected serum biomarkers [bone-specific alkaline phosphatase (BAP), osteocalcin, tartrate-resistant acid phosphatase (TRAP), C-terminal telopeptide fragment of type I collagen (CTx), deoxypyridinoline (DPD), 25-hydroxy vitamin D (25(OH)D), and parathyroid hormone (PTH)] in 56 women (20.3+/-1.8 years) before, during and after eight weeks of training. We also measured bone mineral density (BMD) at regional areas of interest using DXA and pQCT. Biomarkers of bone formation (BAP and osteocalcin) increased in the Resistance and Combined groups (p<0.05), while biomarkers of bone resorption (TRAP and DPD) decreased and increased, respectively, after training (p<0.05) in all groups. Small changes in volumetric and areal BMD (p<0.05) were observed in the distal tibia in the Aerobic and Combined groups, respectively. Mean weekly OIs were 16.0+/-1.9, 20.6+/-2.2, and 36.9+/-5.2 for the Resistance, Aerobic, and Combined groups, respectively. The calculated osteogenic potential of our programs did not correlate with the observed changes in biomarkers of bone turnover. The results of the present study demonstrate that participation in an eight week physical training program that incorporates a resistance component by previously inactive young women results in alterations in biomarkers of bone remodeling indicative of increased formation without substantial alterations in markers of resorption.
Lester
Mark E
ME
Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Building 42, Kansas Street, Natick, MA 01760, USA.
Urso
Maria L
ML
Evans
Rachel K
RK
Pierce
Joseph R
JR
Spiering
Barry A
BA
Maresh
Carl M
CM
Hatfield
Disa L
DL
Kraemer
William J
WJ
Nindl
Bradley C
BC
D015502:Absorptiometry, Photon; D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000378:metabolism; D000596:Amino Acids / Q000097:blood; D000886:Anthropometry; D015415:Biomarkers / Q000378:metabolism; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000201:enzymology / Q000378:metabolism*; D024042:Collagen Type I / Q000097:blood; D004032:Diet; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D015675:Osteocalcin / Q000097:blood; D010012:Osteogenesis / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000097:blood; D010809:Physical Fitness / Q000502:physiology*; D000071681:Tartrate-Resistant Acid Phosphatase; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D055815:Young Adult
D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D007527:Isoenzymes; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D014807:Vitamin D; C036020:deoxypyridinoline; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase