title: Rheumatic manifestations of hepatitis B and C and their association with viral load and fibrosis of the liver.
abstract: The objective of this study is to investigate rheumatologic manifestations of hepatitis B and C and their relation with viral load and degree of hepatic fibrosis. Thirty-six HBV and 36 HBV patients were included. Liver biopsy was performed for all participants. We detected arthralgia 53-50%, myalgia 58-61% and fatigue 64-81% in HBV and HCV groups in order. All manifestations did not differ between groups significantly. Pain intensity was higher in HCV group (P = 0.023). Arthralgia is associated with viral load of the patients in both groups (P = 0.000 and P = 0.001). Viral load and fatigue are correlated in both groups (P = 0.000 and P = 0.001). There is a considerable relation between inflammation and arthralgia (P = 0.000) and myalgia (P = 0.033). We conclude that rheumatologic manifestations are common both in HBV and HCV and related with viral load and fibrosis.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Gaziantep University School of Medicine, Gaziantep, Turkey. aydeniz@gantep.edu.tr
authors.forename: Ali
authors.initials: A
authors.lastname: Aydeniz
authors.forename: M
authors.initials: M
authors.lastname: Namiduru
authors.forename: I
authors.initials: I
authors.lastname: Karaoglan
authors.forename: O
authors.initials: O
authors.lastname: Altindag
authors.forename: E
authors.initials: E
authors.lastname: Yagiz
authors.forename: S
authors.initials: S
authors.lastname: Gursoy
mesh_terms: D000328:Adult; D018771:Arthralgia / Q000473:pathology / Q000503:physiopathology* / Q000821:virology; D001706:Biopsy; D004185:Disability Evaluation; D005221:Fatigue / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007596:Joints / Q000503:physiopathology; D008099:Liver / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000473:pathology / Q000503:physiopathology* / Q000821:virology; D008297:Male; D009135:Muscular Diseases / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D010146:Pain / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D010147:Pain Measurement; D011788:Quality of Life; D012216:Rheumatic Diseases / Q000473:pathology / Q000503:physiopathology* / Q000821:virology; D019562:Viral Load