The cell surface glycoprotein CDCP1 in cancer--insights, opportunities, and challenges.
In the last few years dysregulated expression of the cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) has been associated with several cancers and this cell surface molecule has been recognized both as a tumor marker and as a potential target to disrupt progression of cancer. Here we summarize what is known about CDCP1 including its structural features, expression in normal and cancerous tissues, and the in vitro experiments and studies in animal models that have provided the key insights into its potential role in tumor formation and metastasis in humans. We conclude by highlighting opportunities and challenges in targeting CDCP1 in cancer.
Wortmann
Andreas
A
Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Kelvin Grove, QLD, Australia.
He
Yaowu
Y
Deryugina
Elena I
EI
Quigley
James P
JP
Hooper
John D
JD
D000595:Amino Acid Sequence; D015703:Antigens, CD / Q000502:physiology*; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D018450:Disease Progression; D006412:Hematopoietic Stem Cells / Q000502:physiology; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D010766:Phosphorylation; D016415:Sequence Alignment; D013234:Stem Cells / Q000502:physiology; D019061:src-Family Kinases / Q000502:physiology
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C432044:CDCP1 protein, human; D015815:Cell Adhesion Molecules; D009363:Neoplasm Proteins; D019061:src-Family Kinases