Friend leukemia virus integration-1 (FLI-1) expression in gastrointestinal stromal tumors.
OBJECTIVE
Friend leukemia virus integration-1 expression has been shown in a variety of tumors, including vascular tumors, desmoplastic small round cell tumor, Merkel cell carcinoma, and lymphoblastic lymphoma, in addition to Ewing's sarcoma/primitive neuroectodermal tumor. The aim of the current study was to examine Friend leukemia virus integration-1 protein expression in a series of gastrointestinal stromal tumors and also to assess if Friend leukemia virus integration-1 has any role in the disease process. It is the first study analyzing Friend leukemia virus integration-1 expression in gastrointestinal stromal tumors in the English literature.


METHODS
A tissue microarray block containing 52 cases of gastrointestinal stromal tumors was done. Immunohistochemical analysis was performed for Friend leukemia virus integration-1 polyclonal antibody.


RESULTS
Immunohistochemically, Friend leukemia virus integration-1 was negative in all cases.


CONCLUSIONS
Friend leukemia virus integration-1 can be expressed in a variety of tumors, and is helpful in making the diagnosis of Ewing's sarcoma/primitive neuroectodermal tumor. We think that this protein is not expressed in gastrointestinal stromal tumors and it is not a part of the pathogenesis of this disease.
Kaygusuz
Gülşah
G
Department of Pathology, Ankara University, School of Medicine, Ankara, Turkey. gulsah@gmail.com
Kuzu
Işinsu
I
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D051789:Proto-Oncogene Protein c-fli-1 / Q000235:genetics / Q000378:metabolism*
D014408:Biomarkers, Tumor; C078433:FLI1 protein, human; D051789:Proto-Oncogene Protein c-fli-1