In vitro effects of molecular nanosomal hybrid compositions with oxidized dextrans, conjugated with isonicotinic acid hydrazine on peritoneal macrophages.
The effects of molecular nanosomal hybrid compositions consisting of nanoliposomes with oxidized dextrans (mol. weights 35 and 60 kDa) conjugated with isonicotinic acid hydrazine (dextrazides) on peritoneal macrophages were studied in vitro. Incubation of peritoneal cells with molecular nanosomal hybrid compositions modified the immunological phenotype of macrophage populations, which reflected an increase in their functional activity. Molecular nanosomal hybrid compositions containing dextrazide with 60-kDa dextran more effectively activated macrophages.
Shkurupy
V A
VA
Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. ccem@soramn.ru
Arkhipov
S A
SA
Tkachev
V O
VO
Troitsky
A V
AV
Luzgina
N G
NG
Zaikovskaja
M V
MV
Gulyaeva
E P
EP
Bistrova
T N
TN
Ufimtceva
E G
EG
D000818:Animals; D002478:Cells, Cultured; D003911:Dextrans / Q000737:chemistry*; D005260:Female; D006834:Hydrazines / Q000737:chemistry*; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D007539:Isonicotinic Acids / Q000737:chemistry*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry* / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D010084:Oxidation-Reduction
D003911:Dextrans; D006834:Hydrazines; D053645:Interleukin-2 Receptor alpha Subunit; D007539:Isonicotinic Acids; D018950:Lipopolysaccharide Receptors; D008081:Liposomes