title: Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages.
abstract: OBJECTIVE
  To clarify the relationship between lipid levels and ischemic heart disease (IHD) and cerebrovascular disease (CVD) in diabetic individuals.
  
  
  METHODS
  The Japan Cholesterol and Diabetes Mellitus Study is a prospective cohort study of 4,014 type 2 diabetic patients (1,936 women; mean +/- SD age 67.4 +/- 9.5 years). Lipid and glucose levels and other factors were investigated in relation to occurrence of IHD or CVD.
  
  
  RESULTS
  IHD and CVD occurred in 1.59 and 1.43% of participants, respectively, over a 2-year period. The relation of lower HDL or higher LDL cholesterol to occurrence of IHD in subjects <65 years old was significant. Lower HDL cholesterol was also significantly related to CVD in subjects >or=65 years old and especially in those >75 years old (n = 1,016; odds ratio 0.511 [95% CI 0.239-0.918]; P < 0.05). Stepwise multiple regression analysis with onset of CVD as a dependent variable showed the same result.
  
  
  CONCLUSIONS
  Lower HDL cholesterol is an important risk factor for not only IHD but also CVD, especially in diabetic elderly individuals.
authors.affiliation: Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. hayashi@med.nagoya-u.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Hayashi
authors.forename: Seinosuke
authors.initials: S
authors.lastname: Kawashima
authors.forename: Hideki
authors.initials: H
authors.lastname: Itoh
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yamada
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hattori
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohrui
authors.forename: Koutaro
authors.initials: K
authors.lastname: Yokote
authors.forename: Hideki
authors.initials: H
authors.lastname: Nomura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Umegaki
authors.forename: Akihisa
authors.initials: A
authors.lastname: Iguchi
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D050197:Atherosclerosis / Q000097:blood / Q000453:epidemiology*; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood* / Q000172:deficiency*; D015331:Cohort Studies; D003925:Diabetic Angiopathies / Q000097:blood*; D005260:Female; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000453:epidemiology*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008055:Lipids