title: Case report of implant placement in a patient with Paget's disease on bisphosphonate therapy.
abstract: Paget's disease is the second most common bone disease following osteoporosis. Paget's disease is characterized by abnormal resorption and deposition of bone. The most widely used agents to treat Paget's disease are bisphosphonates. Bisphosphonates have been given much attention due to reports of osteonecrosis associated with their use. This case report demonstrates the placement of implants in a patient with Paget's disease on a six-month-course of bisphosphonate therapy. The patient had post-operative complications and a secondary placement but no signs of bisphosphonate-associated osteonecrosis of the jaw (ONJ). Although complications may exist, the placement of implants in a patient with Paget's disease taking bisphosphonates can have a positive outcome.
authors.affiliation: University of Michigan School of Dentistry, USA.
authors.forename: Flavia Q
authors.initials: FQ
authors.lastname: Pirih
authors.forename: Mark
authors.initials: M
authors.lastname: Zablotsky
authors.forename: Kitrina
authors.initials: K
authors.lastname: Cordell
authors.forename: Laurie K
authors.initials: LK
authors.lastname: McCauley
mesh_terms: D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D020878:Device Removal; D004164:Diphosphonates / Q000627:therapeutic use*; D012968:Etidronic Acid / Q000627:therapeutic use*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008297:Male; D016348:Osseointegration / Q000502:physiology; D010001:Osteitis Deformans / Q000188:drug therapy*; D012086:Reoperation; D013530:Surgical Wound Infection / Q000209:etiology
chemical_list: D050071:Bone Density Conservation Agents; D015921:Dental Implants; D004164:Diphosphonates; D012968:Etidronic Acid