Role of cardiac glycosides in regulation of the growth of retinal tissue explants.
We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10(-13)M), strophanthin K (10(-13)M) and digoxin (10(-11)M) significantly stimulated explant growth. It was hypothesized that the physiological role of endogenous ouabain is associated with regulation of tissue modeling.
Lopatina
E V
EV
Department of Experimental Pharmacology of V. A. Almazov Federal Heart, Blood and Endocrinology Center, Saint-Petersburg, Russia. evl1112@infran.ru
Karetsky
A V
AV
Penniyaynen
V A
VA
Vinogradova
T V
TV
D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002642:Chick Embryo; D002645:Chickens; D004077:Digoxin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D009924:Organ Culture Techniques; D010042:Ouabain / Q000378:metabolism / Q000494:pharmacology; D012160:Retina / Q000166:cytology / Q000187:drug effects*; D013328:Strophanthins / Q000494:pharmacology
D002301:Cardiac Glycosides; D004791:Enzyme Inhibitors; D013328:Strophanthins; D010042:Ouabain; D004077:Digoxin; C029082:strophanthin K