title: Efficacy of two plant extracts against vaginal trichomoniasis.
abstract: Trichomoniasis vaginalis is now an important worldwide health problem. Metronidazole has so far been used in treatment, but the metronidazole-resistant strains and unpleasant adverse effects have been developed. Treatment of patients with metronidazole refractory vaginal trichomoniasis constitutes a major therapeutic challenge and treatment options are extremely limited. In the present study, 33 metronidazole-resistant T. vaginalis females were treated with a combined course of metronidazole and tinidazole. Those still resistant to the combined treatment were given Commiphora molmol (Myrrh) as two capsules for six to eight successive days on an empty stomach two hours before breakfast. Also, natural plant extract purified from (Roman) was in-vitro investigated for its efficacy against T. vaginalis on fresh Diamond media. The anti-trichomoniasis vaginalis activity of both P. granatum (in-vitro) and C. molmol (in-vivo) extracts gave promising results.
authors.affiliation: Department of Parasitology, Faculty of Pharmacy, and Pharmaceutical Industries, Sinai University, Al-Arish (formerly Cairo Curative Insurance Organization), Cairo, Egypt.
authors.forename: Gehad T M
authors.initials: GT
authors.lastname: El-Sherbini
authors.forename: Bothina R
authors.initials: BR
authors.lastname: El Gozamy
authors.forename: Nevein M
authors.initials: NM
authors.lastname: Abdel-Hady
authors.forename: Tosson A
authors.initials: TA
authors.lastname: Morsy
mesh_terms: D000818:Animals; D000994:Antitrichomonal Agents / Q000737:chemistry / Q000627:therapeutic use; D029744:Commiphora / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D005260:Female; D006801:Humans; D029561:Lythraceae / Q000737:chemistry*; D008795:Metronidazole / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D014011:Tinidazole / Q000494:pharmacology; D014247:Trichomonas Vaginitis / Q000188:drug therapy*; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D000994:Antitrichomonal Agents; D010936:Plant Extracts; D014011:Tinidazole; D008795:Metronidazole