In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae).
Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani, with an IC(50) value of 45 microg/mL, while GPE presented an IC(50) value of 49 microg/mL. Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC(50) values of 3.7 microg/mL and 7.0 microg/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC(50) values (about 20 microg/mL), while Hautriwaic acid lactone led to an IC(50) value of 0.8 microg/mL (D6 clone).
da Silva Filho
A A
AA
Laboratório de Produtos Naturais, Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Av. Dr. Armando Sales de Oliveira, 201, CEP 14404-600, Franca, SP, Brazil. silvafilhoaa@yahoo.com.br
Resende
D O
DO
Fukui
M J
MJ
Santos
F F
FF
Pauletti
P M
PM
Cunha
W R
WR
Silva
M L A
ML
Gregório
L E
LE
Bastos
J K
JK
Nanayakkara
N P D
NP
D000818:Animals; D000962:Antimalarials / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D031175:Baccharis / Q000737:chemistry*; D002522:Chlorocebus aethiops; D007893:Leishmania donovani / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D021261:Parasitic Sensitivity Tests; D010636:Phenols / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D010963:Plasmodium falciparum / Q000187:drug effects; D011429:Propolis; D014315:Triterpenes / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells
D000962:Antimalarials; D010636:Phenols; D010936:Plant Extracts; D014315:Triterpenes; D014344:Trypanocidal Agents; D011429:Propolis