Antimalarial compounds from the stem bark of Vismia laurentii.
A phytochemical study of the stem bark of Vismia laurentii resulted in the isolation of a tetracyclic triterpene, tirucalla-7,24-dien-3-one (1), and seven other known compounds: 3-geranyloxyemodin (2), vismiaquinone A (3), vismiaquinone B (4), bivismiaquinone (5), epifriedelinol (6), betulinic acid (7) and stigmasta-7,22-dien-3-ol (8). The structure of all these compounds was elucidated by spectroscopic means. The stem bark extract and compounds 1 and 3 showed good antimalarial activity against the W2 strain of Plasmodium falciparum.
Noungoue
Diderot T
DT
Department of Organic Chemistry, Faculty of Science, TWAS Research Unit (TRU) of University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon. didetchamo@yahoo.fr
Chaabi
Mehdi
M
Ngouela
Silvère
S
Antheaume
Cyril
C
Boyom
Fabrice F
FF
Gut
Jiri
J
Rosenthal
Philip J
PJ
Lobstein
Annelise
A
Tsamo
Etienne
E
D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D002163:Cameroon; D028084:Clusiaceae / Q000737:chemistry*; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology; D006801:Humans; D018547:Plant Stems / Q000737:chemistry*
D000873:Anthracenes; D000962:Antimalarials; C051736:vismione A