Adhesion within the stem cell niches.
Growing body of evidence confirms that cell-cell and cell-extracellular matrix adhesion within stem cell niches is essential for the establishment and maintenance of niche architecture, for the generation and transmission of short-distance regulatory signals, and for controlling the frequency and nature of stem cell divisions. Recent studies demonstrated that in many stem cell niches, adhesion to support cells and/or extracellular matrix determines orientation of stem cell division plane, thereby contributing to the control of stem cell self-renewal and differentiation. Thus, although further analysis of the implicated molecular mechanisms is required, cadherin-associated and integrin-associated events appear to play essential regulatory roles in tissue-specific stem cell niches.
Raymond
Karine
K
Institut Curie, Centre National de la Recherche Scientifique UMR144, 26 rue d'Ulm, Paris Cedex 05, France.
Deugnier
Marie-Ange
MA
Faraldo
Marisa M
MM
Glukhova
Marina A
MA
D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D009928:Organ Specificity; D055153:Stem Cell Niche / Q000166:cytology* / Q000378:metabolism
D016023:Integrins