Content of steroid hormones in the blood and adrenal glands of mice in the dynamics of BCG- and SiO2-induced granulomatous inflammation.
Individual or combined administration of BCG vaccine and silicon dioxide to male mice induced a nonspecific stress response of the adrenal glands and gonads judging from changes in the concentration of blood cortisol and testosterone. The dynamics of cortisol concentration in the adrenal glands was similar, while changes in progesterone concentration were in antiphase to those in the blood. After combined administration of both inductors of granulomatous inflammation, changes in the concentrations of the studied hormones to a greater extent corresponded to their dynamics after injection of BCG.
Palchikova
N A
NA
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. labend@soramn.ru
Kuzminova
O I
OI
Utkina
N V
NV
Selyatitskaya
V G
VG
Shkurupiy
V A
VA
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001500:BCG Vaccine / Q000633:toxicity*; D006105:Granulomatous Disease, Chronic / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism*; D006728:Hormones / Q000097:blood* / Q000378:metabolism*; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011374:Progesterone / Q000378:metabolism; D012822:Silicon Dioxide / Q000633:toxicity*; D013739:Testosterone / Q000097:blood
D001500:BCG Vaccine; D006728:Hormones; D013739:Testosterone; D011374:Progesterone; D012822:Silicon Dioxide; D006854:Hydrocortisone