title: Circadian misalignment in major depressive disorder.
abstract: It has been hypothesized that the circadian pacemaker plays a role in major depressive disorder (MDD). We sought to determine if misalignment between the timing of sleep and the pacemaker correlated with symptom severity in MDD. Depression severity correlated with circadian misalignment: the more delayed, the more severe the symptoms.
authors.affiliation: Department of Psychiatry, Oregon Health & Science University, Portland, OR 97239, USA. emensj@ohsu.edu
authors.forename: Jonathan
authors.initials: J
authors.lastname: Emens
authors.forename: Alfred
authors.initials: A
authors.lastname: Lewy
authors.forename: John Mark
authors.initials: JM
authors.lastname: Kinzie
authors.forename: Diana
authors.initials: D
authors.lastname: Arntz
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rough
mesh_terms: D000328:Adult; D021081:Chronobiology Disorders / Q000209:etiology*; D003865:Major Depressive Disorder / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D055815:Young Adult