title: Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS).
abstract: To identify the location of pancreatic endocrine tumors, arterial stimulation and venous sampling (ASVS) is known to be useful for insulinoma and gastrinoma, but its usefulness for glucagonoma has not been verified to date. Here we report a case of glucagonoma that was diagnosed by ASVS with calcium loading, in which an approximately 6-fold increase of glucagon was observed in the splenic artery territory. MEN1 gene analysis verified the presence of a mutation and the glucagonoma was confirmed after operation. In conclusion, ASVS could be useful for the diagnosis of glucagonoma.
authors.affiliation: Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita. okauchi@imed2.med.osaka-u.ac.jp
authors.forename: Yukiyoshi
authors.initials: Y
authors.lastname: Okauchi
authors.forename: Takao
authors.initials: T
authors.lastname: Nammo
authors.forename: Hiromi
authors.initials: H
authors.lastname: Iwahashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kizu
authors.forename: Isao
authors.initials: I
authors.lastname: Hayashi
authors.forename: Kohei
authors.initials: K
authors.lastname: Okita
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yamagata
authors.forename: Sae
authors.initials: S
authors.lastname: Uno
authors.forename: Fumie
authors.initials: F
authors.lastname: Katsube
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Ken
authors.initials: K
authors.lastname: Kato
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aozasa
authors.forename: Tonsok
authors.initials: T
authors.lastname: Kim
authors.forename: Keigo
authors.initials: K
authors.lastname: Osuga
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakamori
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tamaki
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Jun-ichiro
authors.initials: J
authors.lastname: Miyagawa
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
mesh_terms: D000368:Aged; D002118:Calcium / Q000494:pharmacology; D005260:Female; D005934:Glucagon / Q000097:blood*; D005935:Glucagonoma / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics; D009154:Mutation / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics
chemical_list: D005934:Glucagon; D002118:Calcium