Inhibitory effects of beta-cyclodextrin and trehalose on nanofibril and AGE formation during glycation of human serum albumin.
The effects of beta-cyclodextrin (beta-CyD) and trehalose on glycation of human serum albumin (HSA) were studied. These additives reduced AGEs and nanofibril formation of HSA under in vitro glycation conditions and improved its helical structure. These were accomplished through direct interactions of them with HSA and alterations in solute-protein interactions.
Sharifi
Esmaeel
E
Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Sattarahmady
Naghmeh
N
Habibi-Rezaei
Mehran
M
Farhadi
Mohammad
M
Sheibani
Nader
N
Ahmad
Faizan
F
Moosavi-Movahedi
Ali Akbar
AA
D002942:Circular Dichroism; D005947:Glucose / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D012709:Serum Albumin / Q000378:metabolism*; D012995:Solubility; D013050:Spectrometry, Fluorescence; D014199:Trehalose / Q000494:pharmacology*; D047392:beta-Cyclodextrins / Q000494:pharmacology*
D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D047392:beta-Cyclodextrins; D014199:Trehalose; D005947:Glucose; C031215:betadex