title: High level of alpha-synuclein mRNA in peripheral lymphocytes of patients with alcohol dependence syndrome.
abstract: The content of mRNA for alpha-synuclein (a key protein of the dopaminergic system) was elevated in the peripheral lymphocytes of patients with alcohol dependence syndrome. Increased level of alpha-synuclein mRNA was not associated with changes in the expression of NR4A2 gene encoding Nurrl, one of the main transcription factors of dopaminergic neurons.
authors.affiliation: St. Petersburg Institute of Nuclear Physics named after B. P. Konstantinov, Russian Academy of Sciences, Leningrad Region, Gatchina, Russia. ataraskina@mail.ru
authors.forename: A E
authors.initials: AE
authors.lastname: Taraskina
authors.forename: V A
authors.initials: VA
authors.lastname: Filimonov
authors.forename: Yu A
authors.initials: YA
authors.lastname: Kozlovskaya
authors.forename: M N
authors.initials: MN
authors.lastname: Morozova
authors.forename: D V
authors.initials: DV
authors.lastname: Gaschin
authors.forename: A L
authors.initials: AL
authors.lastname: Schwarzman
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D000704:Analysis of Variance; D004268:DNA-Binding Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D014157:Transcription Factors / Q000235:genetics; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C539882:NR4A2 protein, human; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D014157:Transcription Factors; D051844:alpha-Synuclein