title: Morphological changes in the liver of pregnant C57Bl/6 mice with BCG granulomatosis.
abstract: Morphological changes in the liver of pregnant C57Bl/6 mice infected with BCG vaccine before pregnancy and on day 13 of gestation were studied by means of light microscopy and morphometry. The formation of BCG granulomas in mice of both groups was followed by a decrease in the numerical density and diameter of granulomas, increase in the volume density of hepatocyte degeneration and necrosis, and rise in the numerical density of binucleate hepatocytes (compared to nonpregnant mice infected with BCG vaccine).
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. cherdanceff@mail.ru
authors.forename: L A
authors.initials: LA
authors.lastname: Cherdantseva
authors.forename: A V
authors.initials: AV
authors.lastname: Yakimova
authors.forename: A P
authors.initials: AP
authors.lastname: Nadeev
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupiy
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000009:adverse effects; D005260:Female; D006099:Granuloma / Q000209:etiology / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008853:Microscopy; D011247:Pregnancy
chemical_list: D001500:BCG Vaccine