title: Pharmacological modulation of Th17.
abstract: Recently, a third subset of Th17 cells has been described. This T helper subset induces the release of chemokines and growth factors and causes neutrophil accumulation in several mammalian organs. Pharmacological intervention blocking Th17 generation as well as IL-17 signaling might prove useful in a variety of diseases including asthma, chronic obstructive pulmonary disease, Crohn's disease, cystic fibrosis, multiple sclerosis, psoriatic disease and rheumatoid arthritis. Here, we describe the patents that address a potential pharmacological use of promoting or targeting IL-17.
authors.affiliation: Institute of Immunology, Faculty of Medicine, Apartado Postal 50109, Caracas, Venezuela. sanctisj@gmail.com
authors.forename: Juan B
authors.initials: JB
authors.lastname: De Sanctis
authors.forename: Jenny V
authors.initials: JV
authors.lastname: Garmendia
authors.forename: Dolores
authors.initials: D
authors.lastname: Moreno
authors.forename: Nancy
authors.initials: N
authors.lastname: Larocca
authors.forename: Michael
authors.initials: M
authors.lastname: Mijares
authors.forename: Camilo
authors.initials: C
authors.lastname: Di Giulio
authors.forename: Margarita
authors.initials: M
authors.lastname: Salazar-Bookaman
authors.forename: Gabriella
authors.initials: G
authors.lastname: Wojewodka
authors.forename: Danuta
authors.initials: D
authors.lastname: Radzioch
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000276:immunology; D020381:Interleukin-17 / Q000037:antagonists & inhibitors* / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects* / Q000276:immunology
chemical_list: D018926:Anti-Allergic Agents; D016207:Cytokines; D020381:Interleukin-17