title: [The functional state of components of the hemostatic system in patients with acute intraoperative blood loss].
abstract: Thrombotic and hemorrhagic events are one of the most common and menacing complications in the postoperative period. This may be attributable to the fact that therapy is by no means always performed by keeping in mind the pattern of dysfunction of the components of the hemostatic system. The purpose of the study was to define the pattern of hemostatic disorders occurring in the intra- and postoperative periods in the presence of significant hemorrhage, the feasibilities of their monitoring and correction. Thirty-seven patients with traumatic surgical interventions for cancer were examined in 4 steps: before surgery, after final intraoperative bleeding arrest, and on days 1 and 3 postoperatively. Intraoperatively, analysis of changes in the functional state of components of the hemostatic system identified 2 types of hemocoagulative responses to surgical trauma and blood loss. These included hypo- and hypercoagulative types. This let the authors make timely and goal-oriented correction of revealed hemocoagulative disorders and achieve positive results on postoperative day 3.
authors.forename: V E
authors.initials: VE
authors.lastname: Shipakov
authors.forename: E G
authors.initials: EG
authors.lastname: Ripp
authors.forename: M B
authors.initials: MB
authors.lastname: Tsyrenzhapov
authors.forename: N V
authors.initials: NV
authors.lastname: Riazantseva
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskiĭ
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical; D001810:Blood Volume; D006401:Hematologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D007902:Length of Stay; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods*; D009369:Neoplasms / Q000601:surgery; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D006401:Hematologic Agents