A crowdsourcing evaluation of the NIH chemical probes.
Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.
Oprea
Tudor I
TI
University of New Mexico Center for Molecular Discovery, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA. toprea@salud.unm.edu
Bologa
Cristian G
CG
Boyer
Scott
S
Curpan
Ramona F
RF
Glen
Robert C
RC
Hopkins
Andrew L
AL
Lipinski
Christopher A
CA
Marshall
Garland R
GR
Martin
Yvonne C
YC
Ostopovici-Halip
Liliana
L
Rishton
Gilbert
G
Ursu
Oleg
O
Vaz
Roy J
RJ
Waller
Chris
C
Waldmann
Herbert
H
Sklar
Larry A
LA
D016208:Databases, Factual; D003657:Decision Making; D055808:Drug Discovery / Q000191:economics / Q000379:methods* / Q000458:organization & administration / Q000592:standards; D015336:Molecular Probe Techniques / Q000592:standards / Q000639:trends*; D015335:Molecular Probes / Q000737:chemistry*; D009316:National Institutes of Health (U.S.); D054852:Small Molecule Libraries / Q000737:chemistry*; D014481:United States
D015335:Molecular Probes; D054852:Small Molecule Libraries