title: Synthesis, DNA binding, docking and photoclevage studies of novel benzo[b][1,8]naphthyridines.
abstract: The synthesis and docking studies of novel benzo[b][1,8]naphthyridines is discribed. The docking studies show that the derivatives prefer to bind the AT-rich region of double stranded DNA (ds-DNA). The maximum binding energy -7.16 (kcal/mol) was observed for benzo[b][1,8]naphthyridine-5-thiol 5a and it is a better candidate as an enantioselective binder to ds-DNA than the other derivatives of benzo[b][1,8]naphthyridines. When photoirradiated at 365 nm, benzo[1,8]-naphthyridines have been found to promote the photocleavage of plasmid pUC19 DNA.
authors.affiliation: Department of Studies and Research in Industrial Chemistry, School of Chemical Sciences, Kuvempu University, Shankaraghatta-577 451, India.
authors.forename: T R Ravikumar
authors.initials: TR
authors.lastname: Naik
authors.forename: H S Bhojya
authors.initials: HS
authors.lastname: Naik
authors.forename: H R Prakash
authors.initials: HR
authors.lastname: Naik
authors.forename: P J
authors.initials: PJ
authors.lastname: Bindu
authors.forename: B G
authors.initials: BG
authors.lastname: Harish
authors.forename: V
authors.initials: V
authors.lastname: Krishna
mesh_terms: D000042:Absorption; D001483:Base Sequence; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism; D015195:Drug Design; D055772:Green Chemistry Technology; D008958:Models, Molecular; D008968:Molecular Conformation; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D010782:Photolysis; D013056:Spectrophotometry, Ultraviolet
chemical_list: D009287:Naphthyridines; D004247:DNA; D003851:Deoxyribonucleases