title: [Reticulocyte haemoglobin content in the diagnosis of iron deficiency].
abstract: BACKGROUND
  The detection of iron deficiency is essential in order to start early treatment to prevent long-term systemic complications of iron deficiency anaemia. Reticulocyte haemoglobin content (CHr) has been shown to be a helpful indicator for detecting iron deficiency before the development of anaemia. The objectives of this study were to evaluate the efficiency of CHr in the assessment of iron deficiency with or without anaemia and to determine the cut-off value with the best diagnostic yield.
  
  
  METHODS
  A descriptive cross-sectional study was carried out on an urban population of both sexes aged 6 months to 14 years. The study protocol included a questionnaire and taking a venous blood sample for a complete blood cell count with CHr and biochemical indicators of iron status.
  
  
  RESULTS
  Samples were obtained for 237 children. A CHr cut-off value of 25 pg had an overall sensitivity of 90.7% and specificity of 80.1% for the diagnosis of iron deficiency with or without anaemia. The value of CHr was below 25 pg in the diagnostic groups with iron deficiency and iron deficiency anaemia, and above this value in the diagnostic groups with non-iron deficient anaemia or normal.
  
  
  CONCLUSIONS
  CHr is a useful hematological marker to identify iron deficiency and iron deficiency anaemia in childhood. A CHr value of 25 pg showed the best performance to identify iron deficiency with or without anaemia.
authors.affiliation: Servicio de Pediatría, Hospital Universitario Reina Sofía, Córdoba, España. mariae.mateos.sspa@juntadeandalucia.es
authors.forename: M E
authors.initials: ME
authors.lastname: Mateos González
authors.forename: J
authors.initials: J
authors.lastname: de la Cruz Bértolo
authors.forename: E
authors.initials: E
authors.lastname: López Laso
authors.forename: M D
authors.initials: MD
authors.lastname: Valdés Sánchez
authors.forename: A
authors.initials: A
authors.lastname: Nogales Espert
mesh_terms: D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003677:Deficiency Diseases / Q000097:blood / Q000175:diagnosis; D005260:Female; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007223:Infant; D000090463:Iron Deficiencies; D008297:Male; D011237:Predictive Value of Tests; D012156:Reticulocytes / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D006454:Hemoglobins