title: MicroRNAs and immune regulatory T cells.
abstract: MicroRNAs (miRNAs)-mediated RNA interference are emerging as an important regulatory pathway for various biological processes, including development, differentiation, and homeostasis. Accumulated evidence suggests that miRNAs regulate T cell and B cell differentiation, proliferation, and apoptosis. Deletion of miRNAs in hematopoietic stem cells or in thymus disrupts T cell homeostasis and results in autoimmunity and abnormal cytokine production. Regulatory T cells are potent immune regulators. In this mini-review, we provide a brief overview of the important roles of miRNAs in the development and function of T cells, especially in immune regulatory T cells.
authors.affiliation: Henry Ford Hospital Immunology Program, Henry Ford Hospital, Detroit, MI, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Kook Heon
authors.initials: KH
authors.lastname: Seo
authors.forename: Henry K
authors.initials: HK
authors.lastname: Wong
authors.forename: Qing-Sheng
authors.initials: QS
authors.lastname: Mi
mesh_terms: D000818:Animals; D017209:Apoptosis; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D049109:Cell Proliferation; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D035683:MicroRNAs / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D016207:Cytokines; D035683:MicroRNAs