title: Evolutionary divergence of Plasmodium falciparum: sequences, protein-protein interactions, pathways and processes.
abstract: In this article we review the organism-wide biological data available for Plasmodium falciparum (P. falciparum), a malarial parasite, in relation to the data available for other organisms. We provide comparisons at different levels such as amino acid sequences of proteins encoded in the genomes, protein-protein interaction features, metabolic and signaling pathways and processes. Our comparative analyses highlights that P. falciparum is highly diverged compared to most other eukaryotes at all these levels. Despite the extensive variation some of the physical associations between proteins, such as RNA polymerase complex and CDK-cyclin complex are expected to be conserved given their fundamental importance and ubiquitous nature. We also discuss examples of protein-protein interactions across human and P. falciparum potentially happening during pathogenesis.
authors.affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Tyagi
authors.forename: Lakshmipuram Seshadri
authors.initials: LS
authors.lastname: Swapna
authors.forename: Smita
authors.initials: S
authors.lastname: Mohanty
authors.forename: Garima
authors.initials: G
authors.lastname: Agarwal
authors.forename: Venkatraman Subramanian
authors.initials: VS
authors.lastname: Gowri
authors.forename: Krishanpal
authors.initials: K
authors.lastname: Anamika
authors.forename: Makani Leena
authors.initials: ML
authors.lastname: Priya
authors.forename: Oruganty
authors.initials: O
authors.lastname: Krishnadev
authors.forename: Narayanaswamy
authors.initials: N
authors.lastname: Srinivasan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019143:Evolution, Molecular; D006790:Host-Parasite Interactions / Q000235:genetics*; D006801:Humans; D016778:Malaria, Falciparum / Q000235:genetics; D010963:Plasmodium falciparum / Q000235:genetics* / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D015800:Protozoan Proteins