title: [B-chronic lymphocytic leukemia: epidemiological study and comparison of MDACC and GIMENA pronostic indexes].
abstract: OBJECTIVE
  The clinical course of B-chronic lymphocytic leukemia (B-CLL) patients is highly heterogeneous and the prognosis of these patients is difficult to predict. In this study, we analysed two new prognostic indexes proposed by the MDACC and GIMEMA group in a random population of B-CCL patients.
  
  
  METHODS
  A follow up study of a cohort of patients was carried out. 265 B-CLL patients diagnosed in the Area Sanitaria de Gijón during 10 years (1997-2007) were analysed in this study. The overall survival of the patients was analysed by the Rai and Binet staging systems and the prognostic indexes proposed by the MDACC and GIMEMA group.
  
  
  RESULTS
  The crude rate was 8.99 per 100.000 populations for year and the adjusted-age rate was 3.47 per 100.000 populations for year. The distribution of patients based on the MDACC index was: 31.4% had low risk, 62% had intermediate risk and 6.6% had high risk. The percentage of 5- and 10-years survival probabilities were 87% and 73% for low risk, 75% and 49% for intermediate risk and 29% and 16% of high risk. The GIMEMA index was unable to predict the overall survival in our patients.
  
  
  CONCLUSIONS
  The rates of B-CLL are higher in our population than previously described, which is probably caused by an earlier diagnosis. Our results indicate that the MDACC prognostic index predicted the overall survival and the prognosis of a random population of patients better than the classical staging systems. The simplicity and utility of this prognostic index may help clinicians in clinical decision and therapeutical management.
authors.affiliation: Servicio de Hematología, Hospital Cabueñes, Gijón, Asturias, España. anapilar.gonzalez@sespa.princast.es
authors.forename: Ana Pilar
authors.initials: AP
authors.lastname: González Rodríguez
authors.forename: Esther
authors.initials: E
authors.lastname: González García
authors.forename: Carmen
authors.initials: C
authors.lastname: Fernández Alvarez
authors.forename: Ana Julia
authors.initials: AJ
authors.lastname: González Huerta
authors.forename: Segundo
authors.initials: S
authors.lastname: González Rodríguez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate