Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour.
The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, alpha(v)beta(3) and alpha(5)beta(1) integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated.
Morgan
Mark R
MR
Faculty of Life Sciences, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK.
Byron
Adam
A
Humphries
Martin J
MJ
Bass
Mark D
MD
D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D039081:Integrin alpha5beta1 / Q000502:physiology*; D039302:Integrin alphaVbeta3 / Q000502:physiology*; D021962:Membrane Microdomains / Q000502:physiology; D021381:Protein Transport; D017469:Receptors, Fibronectin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D020830:rac1 GTP-Binding Protein / Q000378:metabolism
D039081:Integrin alpha5beta1; D039302:Integrin alphaVbeta3; D017469:Receptors, Fibronectin; D020830:rac1 GTP-Binding Protein