title: Comparison of mean deviation with AGIS and CIGTS scores in association with structural parameters in glaucomatous eyes.
abstract: OBJECTIVE
  To evaluate which of the 3 clinically used visual field indices including mean deviation (MD), Advanced Glaucoma Intervention Study (AGIS) score, and Collaborative Initial Glaucoma Treatment Study (CIGTS) score are best in evaluating functional damage of glaucomatous optic neuropathy.
  
  
  METHODS
  In 213 glaucomatous eyes, peripapillary retinal nerve fiber layer thickness (RNFLT) and optic disc configuration were measured with Stratus optical coherence tomography and Heidelberg Retina Tomograph-2, respectively. Visual field was measured with standard automated perimetry 30-2. Correlations of the structural parameters compared with the 3 VF indices using second polynomial regression were calculated. In addition, these correlations were analyzed among eyes of 3 different stages of glaucoma, as defined by MD score (early, MD> or =-6 dB; moderate, -12 dB< or =MD<-6 dB; advanced, MD<-12 dB).
  
  
  RESULTS
  Among structure-function relationships in all subjects, the highest correlation determination (R) was MD with RNFLT (=0.298). CIGTS score showed better R than MD or AGIS score with rim area, but these values were not higher than any R with RNFLT. In analyses of 3 groups depending on MD, statistically significant structure-function correlations were observed only in patients with an advanced stage.
  
  
  CONCLUSIONS
  No clear difference was found among MD and AGIS/CIGTS scores in expressing functional damage of glaucomatous eyes. MD is suggested to be no worse than others in monitoring glaucoma in clinical setting.
authors.affiliation: Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Naka
authors.forename: Akiyasu
authors.initials: A
authors.lastname: Kanamori
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Tatsumi
authors.forename: Miyuki
authors.initials: M
authors.lastname: Fujioka
authors.forename: Azusa
authors.initials: A
authors.lastname: Nagai-Kusuhara
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamura
authors.forename: Akira
authors.initials: A
authors.lastname: Negi
mesh_terms: D000328:Adult; D003941:Diagnostic Techniques, Ophthalmological / Q000592:standards; D018450:Disease Progression; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology; D012044:Regression Analysis; D012160:Retina / Q000473:pathology; D058609:Visual Field Tests; D014794:Visual Fields