title: Porous materials from titanium-cobalt alloys for hybrid implants.
abstract: We proposed a new method to increase the biocompatibility of porous materials that were synthesized from titanium and cobalt allows by the method of self-propagating high-temperature synthesis. This method suggested the introduction of calcium hydroxyapatite into the reaction mixture. Administration of calcium hydroxyapatite into the reaction mixture had a modifying effect on the structure and surface of the pore space and biocompatibility of composite materials. Administration of calcium hydroxyapatite crystals was followed by a significant decrease in the size of pores and appearance of water-soluble fractions, which inhibited the activity of cells. However, treatment with amorphous nanodispersed calcium hydroxyapatite increased the biocompatibility and adhesiveness of materials for mesenchymal stem cells. The pore space and mechanical characteristics of materials obtained with amorphous nanodispersed calcium hydroxyapatite were similar to the properties of natural bone. Moreover, these materials surpassed titanium-cobalt allows in biocompatibility. Our results indicate that the introduction of amorphous nanodispersed calcium hydroxyapatite into the reaction mixture during self-propagating high-temperature synthesis has a modifying effect on the pore space of composite materials and increases their biocompatibility and adhesiveness for cells. We conclude that these materials may be used as a carrier of stem cells and progenitor cells in hybrid implants.
authors.affiliation: Institute of Structural Macrokinetics and Problems of Material Sciences, Russian Academy of Sciences, Chernogolovka, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Sytschev
authors.forename: S G
authors.initials: SG
authors.lastname: Vadchenko
authors.forename: O K
authors.initials: OK
authors.lastname: Kamynina
authors.forename: E N
authors.initials: EN
authors.lastname: Balikhina
authors.forename: I G
authors.initials: IG
authors.lastname: Plashchina
authors.forename: E A
authors.initials: EA
authors.lastname: Krylova
authors.forename: A S
authors.initials: AS
authors.lastname: Grigor'yan
authors.forename: A K
authors.initials: AK
authors.lastname: Toporkova
authors.forename: A N
authors.initials: AN
authors.lastname: Konovalov
authors.forename: I I
authors.initials: II
authors.lastname: Selezneva
mesh_terms: D000497:Alloys; D001672:Biocompatible Materials; D003035:Cobalt; D019736:Prostheses and Implants; D014025:Titanium
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D003035:Cobalt; D014025:Titanium