title: Preorganized macromolecular gene delivery systems: amphiphilic beta-cyclodextrin "click clusters".
abstract: Gene delivery systems based on the beta-cyclodextrin scaffold have been synthesized by combining the copper(I)-catalyzed azide-alkyne coupling ("click chemistry") and an efficient acylation method of the secondary hydroxyls; molecular flexibility, charge density and hydrophobic-hydrophilic balance are critical parameters that can be fine-tuned by the click approach.
authors.affiliation: Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092, Sevilla, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Méndez-Ardoy
authors.forename: Marta
authors.initials: M
authors.lastname: Gómez-García
authors.forename: Carmen
authors.initials: C
authors.lastname: Ortiz Mellet
authors.forename: Natalia
authors.initials: N
authors.lastname: Sevillano
authors.forename: M Dolores
authors.initials: MD
authors.lastname: Girón
authors.forename: Rafael
authors.initials: R
authors.lastname: Salto
authors.forename: F
authors.initials: F
authors.lastname: Santoyo-González
authors.forename: José M
authors.initials: JM
authors.lastname: García Fernández
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000818:Animals; D001386:Azides / Q000737:chemistry; D016466:CHO Cells; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D018014:Gene Transfer Techniques; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000480:Alkynes; D001386:Azides; D046911:Macromolecular Substances; D047392:beta-Cyclodextrins; D003300:Copper; D004247:DNA; C031215:betadex