title: In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae).
abstract: Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani, with an IC(50) value of 45 microg/mL, while GPE presented an IC(50) value of 49 microg/mL. Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC(50) values of 3.7 microg/mL and 7.0 microg/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC(50) values (about 20 microg/mL), while Hautriwaic acid lactone led to an IC(50) value of 0.8 microg/mL (D6 clone).
authors.affiliation: Laboratório de Produtos Naturais, Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Av. Dr. Armando Sales de Oliveira, 201, CEP 14404-600, Franca, SP, Brazil. silvafilhoaa@yahoo.com.br
authors.forename: A A
authors.initials: AA
authors.lastname: da Silva Filho
authors.forename: D O
authors.initials: DO
authors.lastname: Resende
authors.forename: M J
authors.initials: MJ
authors.lastname: Fukui
authors.forename: F F
authors.initials: FF
authors.lastname: Santos
authors.forename: P M
authors.initials: PM
authors.lastname: Pauletti
authors.forename: W R
authors.initials: WR
authors.lastname: Cunha
authors.forename: M L A
authors.initials: ML
authors.lastname: Silva
authors.forename: L E
authors.initials: LE
authors.lastname: Gregório
authors.forename: J K
authors.initials: JK
authors.lastname: Bastos
authors.forename: N P D
authors.initials: NP
authors.lastname: Nanayakkara
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D031175:Baccharis / Q000737:chemistry*; D002522:Chlorocebus aethiops; D007893:Leishmania donovani / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D021261:Parasitic Sensitivity Tests; D010636:Phenols / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D010963:Plasmodium falciparum / Q000187:drug effects; D011429:Propolis; D014315:Triterpenes / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000962:Antimalarials; D010636:Phenols; D010936:Plant Extracts; D014315:Triterpenes; D014344:Trypanocidal Agents; D011429:Propolis