[Association of the morphological features of gastric parietal cells with the concentration of H+/K+/ATPase autoantibodies in chronic gastrititis].
Chronic gastritis was morphologically verified in 119 patients. The count of parietal cells per 100 epitheliocytes of fundic glands was estimated. The sizes of parietal cells were measured by the morphometric computer program Videotest. For the diagnosis of autoimmune chronic gastritis (ACG), the level of antibodies to H+K+ATPase of gastric parietal cells in the patients' serum was determined by enzyme immunoassay. Childhood ACG has been found to be characterized by hyperplasia and structural changes of parietal cells with their preserved total count. The specific features of adult ACG include a significant reduction in the number of parietal cells, their sizes depending on the level of antiparietal autoantibodies, and marked ultrastructural changes as impairments in the differentiation and destruction of cytoplasm, organelles, and cell membrane.
Azanchevskaia
S V
SV
Ivanova
V F
VF
Novikova
V P
VP
Anichkov
N M
NM
Antonov
P V
PV
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood* / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D002462:Cell Membrane / Q000201:enzymology / Q000276:immunology / Q000648:ultrastructure; D002648:Child; D002908:Chronic Disease; D003593:Cytoplasm / Q000201:enzymology / Q000276:immunology / Q000648:ultrastructure; D005260:Female; D005756:Gastritis / Q000097:blood* / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D017506:H(+)-K(+)-Exchanging ATPase / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015388:Organelles / Q000201:enzymology / Q000276:immunology / Q000648:ultrastructure; D010295:Parietal Cells, Gastric / Q000378:metabolism* / Q000648:ultrastructure*
D001323:Autoantibodies; D017506:H(+)-K(+)-Exchanging ATPase