BCG granulomatosis in adult mice of different strains with a history of intrauterine hypoxia.
Specific features of the formation and spontaneous regression of BCG granulomas, depending on mouse genotype and history of intrauterine hypoxia, were detected in 2-month-old male CBA and C57Bl/6 mice. The numerical density of granulomas, their size and (partially) cell composition varied. There are good grounds to assume that the number of BCG granulomas in the liver, irrespective of the experimental conditions and animal strains, decreases after elimination of M. tuberculosis persisting in granuloma phagocytes and subsequent migration of cells constituting the granuloma.
Nadeev
A P
AP
Research Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. nadeevngma@mail.ru
Kuznetsova
I V
IV
Shkurupiy
V A
VA
D000818:Animals; D001500:BCG Vaccine / Q000009:adverse effects*; D005260:Female; D005311:Fetal Hypoxia / Q000503:physiopathology*; D006099:Granuloma / Q000209:etiology* / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
D001500:BCG Vaccine