Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis.
The first synthesis of two natural triterpenoid saponins, which were isolated from the roots of Pulsatilla chinensis and exhibited excellent in vitro cytotoxic activity against HL-60 cells, was concisely achieved in a convergent approach. We employed an odourless 2-methyl-5-tert-butylphenyl (Mbp) thioglycoside and trichloroacetimidate donors in one-pot reaction as a key step.
Liu
Qingchao
Q
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Wang
Peng
P
Zhang
Lei
L
Guo
Tiantian
T
Lv
Guokai
G
Li
Yingxia
Y
D000081:Acetamides; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*; D062845:Chloroacetates; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D018517:Plant Roots / Q000737:chemistry*; D031946:Pulsatilla / Q000737:chemistry*; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*; D013865:Thioglycosides / Q000737:chemistry; D014238:Trichloroacetic Acid / Q000737:chemistry
D000081:Acetamides; D001688:Biological Products; D062845:Chloroacetates; D012503:Saponins; D013865:Thioglycosides; D014238:Trichloroacetic Acid; D009828:Oleanolic Acid; C009528:trichloroacetamide