title: [Influence of electroacupuncture of "Shuigou" (GV 26) on hippocampal CGRP and NPY contents in cerebral ischemia rats].
abstract: OBJECTIVE
  To observe the effect of electroacupuncture (EA) on the contents of hippocampal calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY) in cerebral ischemia (CI) rats.
  
  
  METHODS
  Forty SD rats were randomly divided into normal control, sham operation (sham), model and EA groups with 10 cases in each. CI model was duplicated by middle cerebral artery occlusion. EA (2 Hz, 1 mA, continuous waves) was applied to "Shuigou" (GV 26) for 30 min, once daily for 5 days. Hippocampal tissue was taken for assaying the contents of CGRP and NPY with radioimmunoassay.
  
  
  RESULTS
  Compared with sham group and normal control group, hippocampal CGRP content in model group decreased apparently (P<0.01), while NPY content of model group increased significantly (P<0.01). Compared with model group, hippocampal CGRP in EA group increased considerably (P<0.01) and NPY content decreased obviously (P<0.01).
  
  
  CONCLUSIONS
  Electroacupuncture of GV26 can effectively adjust hippocampal CGRP and NPY contents in CI rats, which may contribute to its effect in improving cerebral ischemia.
authors.affiliation: School of Acu-moxibustion, Hubei College of Traditional Chinese Medicine, Wuhan 430061, China. weihuang@hbtcm.edu.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Xu-ping
authors.initials: XP
authors.lastname: Wu
authors.forename: Yun
authors.initials: Y
authors.lastname: Ding
authors.forename: Ya-wen
authors.initials: YW
authors.lastname: Wang
authors.forename: Shu-ju
authors.initials: SJ
authors.lastname: Wang
authors.forename: Guo-jie
authors.initials: GJ
authors.lastname: Sun
mesh_terms: D015669:Acupuncture Points; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000628:therapy*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D004195:Disease Models, Animal; D015671:Electroacupuncture; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats
chemical_list: D009478:Neuropeptide Y; D015740:Calcitonin Gene-Related Peptide