Exploring rat plasmatic proteomes: what triggered the liver regeneration?
To further clarify the priming mechanism of liver regeneration, proteins and protein complexes from rat plasma (normal group, partial hepatectomy (PHx) group and sham-operation group) were comparatively studied by two-dimensional gel electrophoresis and two-dimensional blue native gel electrophoresis. Our results suggested that Kupffer cell--NF-kappaB/ROS might trigger the liver regeneration.
Deng
X Y
XY
State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, PR China.
Li
W R
WR
Sun
Y W
YW
Wei
H D
HD
Jiang
Y
Y
He
F C
FC
D000818:Animals; D015153:Blotting, Western; D015180:Electrophoresis, Gel, Two-Dimensional; D053263:Gene Regulatory Networks; D006242:Haptoglobins / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D020543:Proteome / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D015203:Reproducibility of Results; D015398:Signal Transduction; D054460:rho-Associated Kinases / Q000378:metabolism
D006242:Haptoglobins; D020543:Proteome; D054460:rho-Associated Kinases