title: The results of prenatal screening in the group of 2285 pregnant women from Western Pomeranian Region of Poland diagnosed between 2005-2006.
abstract: In the following paper we have presented the results of non-invasive and invasive prenatal diagnostic tests performed on 2285 pregnant women from the Western-Pomeranian Region between 2005 and 2006.
  
  
  METHODS
  Retrospective analysis of screening tests on 2285 pregnant women. Medical history, including age, weight, familial data pedigrees up to third degree relatives, accompanying diseases, gestational complications in the family, type, dosage and period of any drugs intake, was obtained. Sonographic screening and evaluation of maternal serum PAPP-A and betaHCG levels.
  
  
  RESULTS
  Screening tests identified 4.5% high-risk pregnancies in this group. 69% of the patients consented to invasive diagnosis. As a result, genetic anomalies were detected in 43.7% of cases. Significant differences in betaHCG levels correlated with oral gestagens intake and place of residence (coastal areas).
  
  
  CONCLUSIONS
  Broad use of certified non-invasive methods of prenatal screening allow substantial reduction of invasive procedures with high levels of positive prediction. Medical drugs intake as well as place of inhabitation may influence on free betaHCG levels.
authors.affiliation: Unit of Cytogenetics, Department of Pathology, Pomeranian Medical University, Szczecin, Poland. kjp@onet.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Piotrowski
authors.forename: Wojciech
authors.initials: W
authors.lastname: Halec
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Medrek
authors.forename: Jerzy
authors.initials: J
authors.lastname: Wegrzynowski
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Celewicz
authors.forename: Stanisław
authors.initials: S
authors.lastname: Zajaczek
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis; D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D005817:Genetic Counseling / Q000706:statistics & numerical data; D006801:Humans; D008403:Mass Screening / Q000706:statistics & numerical data*; D008487:Medical History Taking / Q000706:statistics & numerical data*; D011044:Poland / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D018566:Pregnancy, High-Risk / Q000097:blood; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism; D011295:Prenatal Care / Q000706:statistics & numerical data; D011296:Prenatal Diagnosis / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D016387:Women's Health; D055815:Young Adult
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A