title: Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria.
abstract: Antibiotic resistance and virulence of pathogenic mycobacteria are phenotypically associated, but the underlying genetic linkage has not been known. Here we show that PknG, a eukaryotic-type protein kinase previously found to support survival of mycobacteria in host cells, is required for the intrinsic resistance of mycobacterial species to multiple antibiotics.
authors.affiliation: Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Wood Building, 10900 Euclid Avenue, Cleveland, OH 44106-4960, USA.
authors.forename: Kerstin A
authors.initials: KA
authors.lastname: Wolff
authors.forename: Hoa T
authors.initials: HT
authors.lastname: Nguyen
authors.forename: Richard H
authors.initials: RH
authors.lastname: Cartabuke
authors.forename: Ajay
authors.initials: A
authors.lastname: Singh
authors.forename: Sam
authors.initials: S
authors.lastname: Ogwang
authors.forename: Liem
authors.initials: L
authors.lastname: Nguyen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015153:Blotting, Western; D017869:Cyclic GMP-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism*; D004352:Drug Resistance, Microbial / Q000235:genetics*; D009161:Mycobacterium / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D010588:Phagosomes / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D017869:Cyclic GMP-Dependent Protein Kinases