Comparative evaluation of two methods for studies of experimental focal ischemia: magnetic resonance tomography and triphenyltetrazoleum detection of brain injuries.
The volumes of foci of injuries, evaluated by T2-suspended MRT images and analysis of histological sections stained by triphenyltetrazoleum chloride, were compared on a model of unilateral intravascular blocking of the middle cerebral artery branch. The two methods for evaluation of foci of lesions gave close results, correlating with the severity of neurological deficiency in animals subjected to ischemia, manifesting in behavioral tests.
Silachev
D N
DN
AN Belozyorsky Institute of Physicochemical Biology, Training and Research Interfaculty Center of Magnetic Tomography and Spectroscopy, MV Lomonosov Moscow State University, Moscow, Russia. proteins@mail.ru
Uchevatkin
A A
AA
Pirogov
Yu A
YA
Zorov
D B
DB
Isaev
N K
NK
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051381:Rats; D013778:Tetrazolium Salts / Q000737:chemistry*
D013778:Tetrazolium Salts; C009591:triphenyltetrazolium