Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.
The purinergic P2X(7) receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.
Gunosewoyo
Hendra
H
School of Chemistry, University of Sydney, NSW 2006, Australia.
Coster
Mark J
MJ
Bennett
Maxwell R
MR
Kassiou
Michael
M
D000818:Animals; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D006146:Guanidines / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006834:Hydrazines / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011485:Protein Binding; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2 / Q000032:analysis / Q000378:metabolism; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
D001549:Benzamides; D001688:Biological Products; D006146:Guanidines; D006834:Hydrazines; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2; D014230:Triazoles; C004711:dicyandiamido