Role of the parasite and host cytoskeleton in apicomplexa parasitism.
The phylum Apicomplexa includes a large and diverse group of obligate intracellular parasites that rely on actomyosin-based motility to migrate, enter host cells, and egress from infected cells. To ensure their intracellular survival and replication, the apicomplexans have evolved sophisticated strategies for subversion of the host cytoskeleton. Given the properties in common between the host and parasite cytoskeleton, dissecting their individual contribution to the establishment of parasitic infection has been challenging. Nevertheless, recent studies have provided new insights into the mechanisms by which parasites subvert the dynamic properties of host actin and tubulin to promote their entry, development, and egress.
Frénal
Karine
K
Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland. karine.frenal@unige.ch
Soldati-Favre
Dominique
D
D000199:Actins / Q000378:metabolism; D000818:Animals; D016782:Apicomplexa / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism*; D006790:Host-Parasite Interactions; D008954:Models, Biological; D014404:Tubulin / Q000378:metabolism
D000199:Actins; D014404:Tubulin