[Sensitization to three species of mites in allergic patients from the coastal area of Havana city].
BACKGROUND
Sensitization to three allergic mite species (Dermatophagoides pteronyssinus, Dermatophagoides siboney and Blomia tropicalis) from house dust in Cuba has been reported in different studies.


OBJECTIVE
To assess allergic sensitization to these mites in a north coast area of Havana city.


METHODS
A total of 210 allergic patients were selected, classified in two groups: from 1 to 14 years, and from 15 to 55 years. Skin Prick Test (SPT) was performed on all patients using standardized allergenic extracts VALERGEN-BT (B. tropicalis), VALERGEN-DS (D. siboney) and VALERGEN-DP (D. pteronyssinus) manufactured by BIOCEN, Cuba. The test was considered positive when the average wheal diameter was greater or equal to 3 mm.


RESULTS
Both groups showed higher sensitization to D. pteronyssinus (>78%), while for the remaining mites it was below 60%. In patients older than 14 years, the sensitization was apparently higher, although not statistically significant (p > 0.05). Nevertheless, the skin reactivity in this group was significantly greater (p < 0.05) for the three allergens. Unusually, mean wheal size in both groups was significantly superior toward B. tropicalis (p < 0.05).


CONCLUSIONS
In spite of being D. pteronyssinus the mite showing the highest sensitization, Blomia tropicalis showed to be also an important aeroallergen with more than 50% sensitization and greater skin reactivity. Therefore, in our population it would be advisable to perform SPT with the three mites extracts, simultaneously and to combine it in allergen-specific immunotherapy.
Almarales
Raúl L Castro
RL
Departamento de Alergenos, Centro Nacional de Biopreparados (BIOCEN), Bejucal, La Habana, Cuba. rcastro@biocen.cu
Castelló
Mirta Alvarez
MA
Díaz
Mercedes Ronquillo
MR
Canosa
José S Rodríguez
JS
Gómez
Iris García
IG
León
Mayda González
MG
Domínguez
Irene Enríquez
IE
Rosado
Alexis Labrada
AL
Viltre
Bárbara I Navarro
BI
Díaz
Yunia Oliva
YO
Morejón
Maytee Mateo
MM
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000485:Allergens; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003462:Cuba / Q000453:epidemiology; D040002:Dermatophagoides pteronyssinus / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000145:classification / Q000276:immunology*; D039981:Pyroglyphidae / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology* / Q000209:etiology; D012882:Skin Tests; D013045:Species Specificity; D014505:Urban Population; D055815:Young Adult
D000485:Allergens