Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release.
A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some differences in comparison with either IPEC constituents or physical mixture. The swelling of tablets obtained by direct compression was independent of pH, and a maximum value of 742% was attained after 24h. The performance of the IPEC as matrix for controlled release of ibuprofen indicates that drug delivery takes place in a zero-order manner. Experimental dissolution data in the buffer stage were properly represented by a model accounting for contributions of Fickian diffusion and relaxation phenomena; this model suggests that the former predominates over the latter, for the modeled range.
Prado
Héctor J
HJ
Departamento de Química Orgánica (CIHIDECAR-CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, (C1428EGA), Buenos Aires, Argentina.
Matulewicz
María C
MC
Bonelli
Pablo R
PR
Cukierman
Ana L
AL
D000688:Amylose / Q000737:chemistry; D002240:Carbohydrate Sequence; D002351:Carrageenan / Q000737:chemistry; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D004573:Electrolytes / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry*; D013607:Tablets
D004337:Drug Carriers; D004573:Electrolytes; D004364:Pharmaceutical Preparations; D000644:Quaternary Ammonium Compounds; D013607:Tablets; D002351:Carrageenan; D013213:Starch; D000688:Amylose; D007052:Ibuprofen