Hodgkin lymphoma: an update on its biology with new insights into classification.
In the past few years, there has been a greater understanding of the spectrum and biology of Hodgkin lymphoma (HL). In standard texts, HL is classified as 2 distinct entities, namely nodular lymphocyte-predominant HL and classical HL (CHL). However, recent evidence suggests that CHL is not a single disease. Although the mixed cellularity and lymphocyte-depleted subtypes might be part of a biologic continuum, the nodular sclerosis subtype has a distinct epidemiology, clinical presentation, and histology. Nodular sclerosis HL might also be related to primary mediastinal B-cell lymphoma and mediastinal gray-zone lymphomas. We present an update on the pathobiology of HL and discuss these biologic and clinical differences in this review.
Mani
Haresh
H
Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.
Jaffe
Elaine S
ES
D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D016207:Cytokines / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000378:metabolism; D004854:Herpesvirus 4, Human / Q000378:metabolism; D006689:Hodgkin Disease / Q000145:classification* / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D008214:Lymphocytes / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000378:metabolism; D008297:Male; D012923:Social Class
D016207:Cytokines