G-quadruplex-based DNAzyme for sensitive mercury detection with the naked eye.
Hg(2+) is able to inhibit the peroxidase-like DNAzyme function of a T-containing G-quadruplex DNA via Hg(2+)-mediated T-T base pairs, which enables the visual detection of Hg(2+) in the TMB-H(2)O(2) reaction system with high selectivity and sensitivity.
Li
Tao
T
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Li
Bingling
B
Wang
Erkang
E
Dong
Shaojun
S
D000818:Animals; D021881:DNA, Catalytic / Q000737:chemistry* / Q000378:metabolism*; D054856:G-Quadruplexes; D006801:Humans; D008628:Mercury / Q000032:analysis* / Q000737:chemistry*; D016813:Oxytricha / Q000737:chemistry / Q000378:metabolism; D012680:Sensitivity and Specificity; D013053:Spectrophotometry; D016615:Telomere / Q000737:chemistry / Q000378:metabolism; D014785:Vision, Ocular / Q000502:physiology*
D021881:DNA, Catalytic; D008628:Mercury