Effect of thyroxin on behavior of mice with inherited difference in predisposition to catalepsy.
We studied effects of chronic thyroxin administration (2 mg/l, for 60 days) on motor activity, anxiety and depression-like behavior in cataleptic (ASC/Icg) and non-cataleptic (AKR/J) strains of mice. No effects of thyroxin on anxiety indicators in "open field" and "light/dark" tests were revealed in mice of the strains under study. At the same time, thyroxin increased moveability in the "open field" test in AKR/J mice and produced an antidepressant effect in the "forced swimming" test in animals from ASC/Icg strain. Obtained results are indicative of the role of inherited predisposition to catalepsy in determining the sensitivity to thyroid hormones.
Zubkov
E A
EA
Laboratory for Neurogenomics of Behavior, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk State University, Novosibirsk, Russia. zubkov@ngs.ru
Kulikov
A V
AV
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002375:Catalepsy / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects; D013974:Thyroxine / Q000494:pharmacology*
D000928:Antidepressive Agents; D013974:Thyroxine