title: Chronic tongue ulceration resolved by sulpiride: a report of two cases.
abstract: We report two patients with chronic tongue ulceration who were successfully treated using sulpiride. The clinical diagnosis was oral candidiasis related to long-term steroid treatment. The results of the culture test and cytological examination supported this diagnosis, but antifungal treatment was ineffective and the tongue pain in these patients became more severe. Furthermore, the pain could not be relieved by nonsteroidal anti-inflammatory drugs (NSAIDs). We therefore prescribed sulpiride in addition to NSAIDs to reduce the tongue pain. A consequent improvement in both pain severity and ulceration was observed 2-3 weeks after sulpiride administration.
authors.affiliation: Department of Oral Surgery, Osaka Medical College, Osaka, Japan. ora007@poh.osaka-med.ac.j
authors.forename: H
authors.initials: H
authors.lastname: Terai
authors.forename: M
authors.initials: M
authors.lastname: Shimahara
mesh_terms: D000369:Aged, 80 and over; D002180:Candidiasis, Oral / Q000188:drug therapy* / Q000473:pathology; D002908:Chronic Disease; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D019226:Oral Ulcer / Q000188:drug therapy* / Q000473:pathology; D013469:Sulpiride / Q000627:therapeutic use*; D014060:Tongue Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D018492:Dopamine Antagonists; D013469:Sulpiride