Cytotoxic triterpenoids from the stems of Microtropis japonica.
Bioassay-guided fractionation of a methanol extract obtained from stems of Microtropis japonica led to the isolation of six new ursane-type triterpenoids (1-6) and a new 2,3-seco-oleanane-type triterpenoid (7), together with seven known compounds. The structures of the new compounds were elucidated using spectroscopic data analysis. Among the known compounds isolated, the main component, 8 (ursolic acid), was active for HL60 cells, and its effects on histone hyperacetylation and the inhibition of histone deacetylase (HDAC) activity were investigated.
Chen
I-Hsiao
IH
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
Lu
Mei-Chin
MC
Du
Ying-Chi
YC
Yen
Ming-Hong
MH
Wu
Chin-Chung
CC
Chen
Yung-Husan
YH
Hung
Chih-Sheng
CS
Chen
Shu-Li
SL
Chang
Fang-Rong
FR
Wu
Yang-Chang
YC
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D013624:Taiwan; D014315:Triterpenes / Q000494:pharmacology*; D000097245:Ursolic Acid
D000972:Antineoplastic Agents, Phytogenic; D056572:Histone Deacetylase Inhibitors; D009828:Oleanolic Acid; D014315:Triterpenes; D000097245:Ursolic Acid