Counts of stromal precursor cells in the bone marrow and heterotopic bone marrow transplants from mice immunized with group A streptococcus antigens during different periods after immunization.
The counts of stromal precursor cells in bone marrow transplants obtained from animals 2 months after their immunization with killed type 5 group A streptococcus vaccine drop almost 3-fold in comparison with transplants from normal donors. Six months after donor immunization, the count of stromal precursor cells in the transplants reaches the normal level. The count of stromal precursor cells in bone marrow transplants from normal mice transplanted to recipients 6 months after their immunization with killed streptococcus vaccine also virtually did not change in comparison with the counts in bone marrow transplants from normal donors transplanted to normal recipients. The weight and size of bone capsules of 6.5-month bone marrow transplants in intact recipients after transplantation from donors immunized 2 months before with killed type 5 group A streptococcus vaccine was 3-fold lower than in bone marrow transplants collected from intact donors. The content of stromal precursor cells in the femoral bone marrow of animals immunized with killed streptococcus vaccine was 2.5 time higher in comparison with the parameter in the femoral bone marrow of normal mice even 8 months after immunization. The results indicate a significant long-acting effect of streptococcal antigens on the bone marrow stromal tissue, specifically, on its osteogenesis potential.
Gorskaya
U F
UF
N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russia. uliya.gorskaya@nearmedic.ru
Danilova
T A
TA
Nesterenko
V G
VG
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation; D006168:Guinea Pigs; D051379:Mice; D008808:Mice, Inbred CBA; D013291:Streptococcus / Q000276:immunology*; D017154:Stromal Cells / Q000166:cytology*
D000942:Antigens, Bacterial