title: Brugada syndrome whose ST-segment changes were enhanced by antihistamines and antiallergenic drugs.
abstract: We describe a case of Brugada syndrome, in which a coved type ST-segment elevation was enhanced by antihistamines and antiallergenic drugs. The patient had been treated with four kinds of antihistamines and antiallergenic drugs. The twelve-lead ECG exhibited a coved type ST-segment elevation in leads V(1) and V(2), and their enhancement was induced by pilsicainide. After discontinuing those drugs, the ST segment elevation in leads V(1) and V(2) became reduced. An ICD implantation was selected for the therapy since ventricular fibrillation was induced. Our report discusses the possible contribution of antihistamines and antiallergenic drugs to the Brugada type ST-segment changes.
authors.affiliation: Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College.
authors.forename: Motoki
authors.initials: M
authors.lastname: Matsuki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Kanako
authors.initials: K
authors.lastname: Matsuda
authors.forename: Masaru
authors.initials: M
authors.lastname: Yamaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakagawa
authors.forename: Naka
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Ota
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Kazumi
authors.initials: K
authors.lastname: Akasaka
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hasebe
mesh_terms: D018926:Anti-Allergic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D053840:Brugada Syndrome / Q000503:physiopathology*; D017147:Defibrillators, Implantable; D004485:Eczema / Q000188:drug therapy; D004562:Electrocardiography; D006633:Histamine Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy
chemical_list: D018926:Anti-Allergic Agents; D006633:Histamine Antagonists