title: Fabrication and design of transdermal fluconazole spray.
abstract: The objective of the present study was to formulate fluconazole transdermal spray for obtaining modified drug transport using eutectic mixture, ethyl cellulose, polyethylene oxide and alcohol. The formulated products were characterized. The selection of the optimized batch was done considering the results of drug transport in the first hour, the time required for 90% drug transport, viscosity and spray angle of the formulations. The inclusion of eutectic mixture, consisting of equal parts of camphor and menthol, showed improved drug transport through rat skin. The optimized batch exhibited larger mean zone of inhibition (antifungal activity), efficient in vivo activity and short term stability.
authors.affiliation: L. M. College of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Opp. Gujarat University, Navrangpura, Ahmedabad, India.
authors.forename: Mukesh C
authors.initials: MC
authors.lastname: Gohel
authors.forename: Stavan A
authors.initials: SA
authors.lastname: Nagori
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D002164:Camphor / Q000008:administration & dosage / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D004355:Drug Stability; D004867:Equipment Design; D015725:Fluconazole / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008610:Menthol / Q000008:administration & dosage / Q000737:chemistry; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry; D051381:Rats; D012869:Skin Absorption; D014005:Tinea / Q000188:drug therapy* / Q000473:pathology; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D008610:Menthol; D011092:Polyethylene Glycols; D002164:Camphor; C013517:ethyl cellulose; D015725:Fluconazole; D002482:Cellulose