title: Intraocular pressure following intravitreal injection of triamcinolone acetonide.
abstract: BACKGROUND
  To investigate the intraocular pressure (IOP) response following intravitreal injection of triamcinolone acetonide.
  
  
  METHODS
  This retrospective consecutive non-comparative case series study included 41 patients (52 eyes) (19 male, 22 female, mean age 64.1 ± 13.44; range 22 - 85 years) with progressive exudative ARMD (n = 10 eyes) or diffuse diabetic macular oedema (42 eyes), who received one or more intravitreal injection(s) of 4 mg triamcinolone acetonide.
  
  
  RESULTS
  IOP increased significantly (p<0.001) from 16.08 (±3.28) mm Hg (range 12-26 mm Hg) preoperatively to a mean maximum of 26.1 (±11.79) mmHg (range 15-80 mm Hg) postoperatively (p<0.001). An IOP rise to values higher than 21 mm Hg was observed in 28 (53.8%) eyes. Elevation of IOP occurred 7.5 weeks (±7.07) after the injection. All five patients (11.9%) with a family history of glaucoma developed an IOP rise above the mean maximum level. The post-injection rise of IOP was statistically independent of gender (p=0.37), but the presence of diabetes mellitus demonstrated a marked influence on the rate of a postoperative elevation of IOP (p=0.05).
  
  
  CONCLUSIONS
  The IOP response following IVTA was consistent with previous studies. A family history of glaucoma and a history of diabetes mellitus may predispose patients to a greater than average IOP rise following IVTA. Careful IOP assessment for at least 6 months post injection is recommended.
authors.affiliation: Maidstone and Tunbridge Wells NHS Trust, Department of Ophthalmology, Maidstone Hospital, Hermitage Lane, Maidstone, ME16 9QQ, UK. e.ansari@nhs.net
authors.forename: Ejaz A
authors.initials: EA
authors.lastname: Ansari
authors.forename: N
authors.initials: N
authors.lastname: Ali