title: Total synthesis and analgesic activity of 6-fluoroindan-1-acetic acid and its 3-oxo derivative.
abstract: 6-Fluoro-3-oxo-indan-1-acetic acid (5) and 6-fluoroindan-1-acetic acid (6) were conveniently synthesised from 3-fluorobenzaldehyde in four and five steps, respectively. The structures of these new compounds and two other intermediates, 3-fluorobenzylidine-bis-acetoacetate (2) and 3-fluoro-beta-phenyl glutaric acid (3) were elucidated by spectroscopic means, notably, HRMS, 1D and 2D NMR. The analgesic activity of compounds 5 and 6 were assessed by the acetic acid induced writhing in Swiss albino mice.
authors.affiliation: Department of Pharmacy, State University of Bangladesh, Dhaka-1209, Bangladesh.
authors.forename: Hasina
authors.initials: H
authors.lastname: Yasmin
authors.forename: Sharmistha
authors.initials: S
authors.lastname: Das
authors.forename: Lutfun
authors.initials: L
authors.lastname: Nahar
authors.forename: M Mehedi
authors.initials: MM
authors.lastname: Masud
authors.forename: M Shafikur
authors.initials: MS
authors.lastname: Rahman
authors.forename: Suvash C
authors.initials: SC
authors.lastname: Roy
authors.forename: M Mukhlesur
authors.initials: MM
authors.lastname: Rahman
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
authors.forename: Joydeb K
authors.initials: JK
authors.lastname: Kundu
authors.forename: Bidyut K
authors.initials: BK
authors.lastname: Datta
authors.forename: Sitesh C
authors.initials: SC
authors.lastname: Bachar
authors.forename: A K Azad
authors.initials: AK
authors.lastname: Chowdhury
authors.forename: Satyajit D
authors.initials: SD
authors.lastname: Sarker
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D019342:Acetic Acid / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001547:Benzaldehydes / Q000737:chemistry; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy
chemical_list: C547091:6-fluoroindan-1-acetic acid; D000085:Acetates; D000700:Analgesics; D001547:Benzaldehydes; D007189:Indans; D019342:Acetic Acid; C032175:benzaldehyde