title: Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease.
abstract: Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Chen
authors.forename: Jiangli
authors.initials: J
authors.lastname: Fan
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Peng
authors.forename: Jingyun
authors.initials: J
authors.lastname: Wang
authors.forename: Shiguo
authors.initials: S
authors.lastname: Sun
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Tong
authors.initials: T
authors.lastname: Wu
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Liu
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.forename: Saijian
authors.initials: S
authors.lastname: Ma
mesh_terms: D000166:Acridines / Q000737:chemistry*; D002384:Catalysis; D002621:Chemistry / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004247:DNA / Q000737:chemistry; D003851:Deoxyribonucleases / Q000737:chemistry*; D015195:Drug Design; D004587:Electrophoresis, Agar Gel / Q000379:methods; D006868:Hydrolysis; D007364:Intercalating Agents / Q000494:pharmacology; D007501:Iron / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D010957:Plasmids / Q000378:metabolism
chemical_list: D000166:Acridines; D007364:Intercalating Agents; D004247:DNA; D007501:Iron; D003851:Deoxyribonucleases