title: Prevalence and trends of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among blood donors in Iran, 2004 through 2007.
abstract: BACKGROUND
  Evaluation and monitoring the prevalence of transfusion-transmissible viral infections in blood donors is a valuable index of donor selection and blood safety. This study analyzed the trends of blood-borne infections among Iranian blood donations during 4 years.
  
  
  METHODS
  Viral screening results of 6,499,851 allogeneic donations from 2004 through 2007 were analyzed. All donations were screened for hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and syphilis. The prevalence of HBV, HCV, and HIV infections per 100,000 donations and 95% confidence interval was calculated. The p value was estimated by chi-square test.
  
  
  RESULTS
  The prevalences of HBV, HCV, and HIV decreased during the 4-year study from 2004 through 2007. The overall prevalence was 0.56% for HBV, 0.004% for HIV, and 0.13% for HCV. There was a significant and impressive decrease in hepatitis B surface antigen prevalence from 0.73% in 2004 to 0.41% in 2007. The prevalence of HIV appeared to have decreased from 0.005% in 2004 to 0.004% in 2007 although the decrease was not significant. HCV prevalence showed a slight decline in blood donations from 0.14% in 2005 to 0.12% in 2007.
  
  
  CONCLUSIONS
  The trends of transfusion-transmitted infection prevalence in Iranian blood donations suggest that most of the safety measures employed in recent years in Iran have been effective.
authors.affiliation: Department of Immunohematology, Research Center of Iranian Blood Transfusion Organization, Tehran, Iran. dr.amini@gmail.com
authors.forename: Sedigheh Amini
authors.initials: SA
authors.lastname: Kafi-abad
authors.forename: Houri
authors.initials: H
authors.lastname: Rezvan
authors.forename: Hassan
authors.initials: H
authors.lastname: Abolghasemi
authors.forename: Ali
authors.initials: A
authors.lastname: Talebian
mesh_terms: D001782:Blood Donors / Q000706:statistics & numerical data*; D015658:HIV Infections / Q000453:epidemiology*; D006509:Hepatitis B / Q000453:epidemiology*; D006526:Hepatitis C / Q000453:epidemiology*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D015995:Prevalence; D065227:Transfusion Reaction