title: Polymer/silica hybrid hollow nanospheres with pH-sensitive drug release in physiological and intracellular environments.
abstract: Hybrid hollow nanospheres of chitosan-silica templated by chitosan-poly(acrylic acid) nanoparticles are fabricated in a complete aqueous system, which provide a pH-sensitive switch in physiological and sub-cell environments for the release of loaded drug.
authors.affiliation: National Laboratory of Solid State Microstructure, Department of Material Science and Engineering, Nanjing University, Nanjing, 210093, P.R. China.
authors.forename: Eryun
authors.initials: E
authors.lastname: Yan
authors.forename: Yin
authors.initials: Y
authors.lastname: Ding
authors.forename: Changjing
authors.initials: C
authors.lastname: Chen
authors.forename: Rutian
authors.initials: R
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
authors.forename: Xiqun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival; D048271:Chitosan / Q000737:chemistry; D015179:Colorectal Neoplasms; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles; D046529:Microscopy, Electron, Transmission; D054118:Nanospheres / Q000737:chemistry*; D012822:Silicon Dioxide
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; C065246:chitosan-poly(acrylic acid); D012822:Silicon Dioxide; D004317:Doxorubicin; D048271:Chitosan