Effect of gadolinium chloride on the growth and metastasizing of lewis pulmonary adenocarcinoma in mice.
A single intraperitoneal injection of GdCl(3)in doses of 14 or 28 mg/kg to mice with intravenously transplanted Lewis pulmonary adenocarcinoma on days 3 or 8 after tumor transplantation reduced the mean number of tumor metastases in the lungs. The effect of GdCl(3)was more pronounced if it was injected at the stage of tumor dissemination (day 8). The positive antimetastatic effect of GdCl(3)was presumably due to its capacity to macrophage depression. The direct (not mediated through mononuclear phagocyte system cells) effect of GdCl(3)on tumor cells cannot also be excluded.
Zhanaeva
S Ya
SY
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. s.ya.zhanaeva@physiol.ru
Alekseenko
T V
TV
Korolenko
T A
TA
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology*; D000818:Animals; D005682:Gadolinium / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000188:drug therapy
D005682:Gadolinium; C038958:gadolinium chloride