Synthesis and investigation of tryptophan-amphotericin B conjugates.
Anchors aweigh! The synthesis of tryptophan-amphotericin B conjugates (see figure) is described. The membrane-anchoring effect of tryptophane was thus combined with the pore-formation effect of amphotericin B leading to high channel activity in sterol-free liposomes.
Zumbuehl
Andreas
A
Department of Chemistry and Applied Biosciences, ETH Zürich, Hönggerberg, Zürich, Switzerland.
Stano
Pasquale
P
Sohrmann
Marc
M
Dietiker
Rolf
R
Peter
Mathias
M
Carreira
Erick M
EM
D000666:Amphotericin B / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008081:Liposomes / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D011188:Potassium / Q000378:metabolism; D014364:Tryptophan / Q000737:chemistry*
D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B; D014364:Tryptophan; D011188:Potassium