title: Modulation of membrane traffic between endoplasmic reticulum, ERGIC and  Golgi to generate compartments for the replication of bacteria and viruses.
abstract: Several bacteria and viruses remodel cellular membranes to form compartments specialised for replication. Bacteria replicate within inclusions which recruit membrane vesicles from the secretory pathway to provide nutrients for microbial growth and division. Viruses generate densely packed membrane vesicles called viroplasm which provide a platform to recruit host and viral proteins necessary for replication. This review describes examples where both intracellular bacteria (Salmonella, Chlamydia and Legionella) and viruses (picornaviruses and hepatitis C) recruit membrane vesicles to sites of replication by modulating proteins that control the secretory pathway. In many cases this involves modulation of Rab and Arf GTPases.
authors.affiliation: Institute of Biomedical and Clinical Sciences, School of Medicine, University of East Anglia, Norfolk NR47TJ, UK.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pierini
authors.forename: Eleanor
authors.initials: E
authors.lastname: Cottam
authors.forename: Rebecca
authors.initials: R
authors.lastname: Roberts
authors.forename: Thomas
authors.initials: T
authors.lastname: Wileman
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000254:growth & development* / Q000378:metabolism; D012328:RNA Viruses / Q000502:physiology*; D053586:Virus Internalization; D014779:Virus Replication