title: A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction.
abstract: A stereoselective synthesis of (+)-physoperuvine, a tropane alkaloid from Physalis peruviana Linne has been developed using a one-pot tandem aza-Claisen rearrangement and ring closing metathesis reaction to form the key amino-substituted cycloheptene ring.
authors.affiliation: WestChem, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow, UK G12 8QQ.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Zaed
authors.forename: Michael D
authors.initials: MD
authors.lastname: Swift
authors.forename: Andrew
authors.initials: A
authors.lastname: Sutherland
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D032321:Physalis / Q000737:chemistry; D013237:Stereoisomerism; D014326:Tropanes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000470:Alkaloids; D014326:Tropanes; C543196:physoperuvine