Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction.
Antimuscarinic effects of ipratropium bromide and atropine are associated with prevention of the development of Arthus reaction, while the cytostatic effects of cyclophosphamide and doxorubicin lead to involution of the thymus and spleen, suppression of antibody production, and aggravation of inflammation, which causes edema of the ankle joint (cyclophosphamide treatment). Apoptosis of tumor cell and inhibition of inflammation can be essential for chemotherapy of malignant and autoimmune diseases.
Nezhinskaya
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S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, the Russian Academy of Medical Sciences, St. Petersburg, Russia. sns@iem.spb.ru
Sapronov
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Vladykin
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Shepeleva
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D000818:Animals; D000843:Ankle Joint / Q000187:drug effects / Q000473:pathology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D018501:Antirheumatic Agents / Q000494:pharmacology; D001183:Arthus Reaction / Q000139:chemically induced*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018679:Cholinergic Agonists / Q000494:pharmacology*; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced; D005702:Galantamine / Q000494:pharmacology; D005730:Ganglionic Blockers / Q000494:pharmacology; D018738:Hexamethonium / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010115:Oxyphenonium / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology
D000903:Antibiotics, Antineoplastic; D018501:Antirheumatic Agents; D018679:Cholinergic Agonists; D018680:Cholinergic Antagonists; D005730:Ganglionic Blockers; D005702:Galantamine; D018738:Hexamethonium; D004317:Doxorubicin; D003520:Cyclophosphamide; D010115:Oxyphenonium