title: Experimental study of ultralow-dose antibodies to cyclophosphamide on cyclophosphamide myelotoxicity.
abstract: The possibility of using ultralow-dose cyclophosphamide for reducing the myelotoxicity of cyclophosphamide, injected in the maximum permissible dose, was studied in mice. Combined treatment by the cytostatic and its ultralow-dose preparation led to a lesser suppression of the erythroid, lymphocytic, and particularly granulocytic hemopoiesis stems. This effect is explained by stimulation of the secretory activity of hemopoiesis-inducing microenvironment and hence, of the functional activity of granulocytopoiesis under the effect of ultralow-dose cyclophosphamide.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. moffice@materiamedica.ru
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: T Y
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D003520:Cyclophosphamide / Q000276:immunology* / Q000633:toxicity*; D015672:Erythroid Precursor Cells / Q000378:metabolism; D055014:Granulocyte-Macrophage Progenitor Cells / Q000378:metabolism; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice
chemical_list: D000906:Antibodies; D003520:Cyclophosphamide