[Cooperation between picornaviral proteins for the overcoming of cellular protective mechanisms].
Picornaviruses can overcome cellular mechanisms of antiviral defense by inhibiting cellular RNA and protein synthesis, nuclear-cytoplasmic transport and secretory pathways. The participation of proteases 2A and 3C and membrane proteins 2B and 3A in these processes is described. Four steps of the viral inhibition of cellular gene expression and the reciprocal supplement between these steps are discussed.
Gavriushina
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D000086042:3C Viral Proteases; D000818:Animals; D017209:Apoptosis / Q000276:immunology; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis; D054884:Host-Pathogen Interactions / Q000276:immunology*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D010849:Picornaviridae / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport / Q000235:genetics; D014758:Viral Core Proteins / Q000235:genetics / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
C101758:2B protein, poliovirus; C109349:3A protein, Poliovirus; D016207:Cytokines; D008565:Membrane Proteins; D009687:Nuclear Proteins; D014758:Viral Core Proteins; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; D003546:Cysteine Endopeptidases; D000086042:3C Viral Proteases; C057400:picornain 2A, Picornavirus