The effect of hyaluronic acid carboxymethyl cellulose on the healing of colonic anastomosis in rats.
BACKGROUND
This study demonstrates the effect of hyaluronic acid-carboxymethylcellulose on the healing of colonic anastomosis.


METHODS
30 female Wistar-Albino rats were divided into three groups; control group 1 (n=10), treated with hyaluronic acid-carboxymethylcellulose, group 2 (n=8) treated with HBO and group 3 with hyaluronic acid-carboxymethylcellulose and HBO.


RESULTS
Bursting pressure and rupture strength were significantly higher in the group 3 compared to other two groups (p<0.05). The severity of necrosis, granulation, neovascularisation and epithelization among groups did not show any significant difference (p>0.05). But the evaluation of inflammation showed a statistical significance (p<0.001) such as as granulation (p<0.05).


CONCLUSIONS
This study did not detect the negative affect of seprafilm on wound healing. Combined treatment with seprafilm and HBO has a favorable therapeutic effect on the healing of ischemic colonic anastomosis (Tab. 4, Fig. 3, Ref. 15). Full Text (Free, PDF) www.bmj.sk.
Adas
Gokhan
G
Istanbul Okmeydani Training Hospital, 2nd General Surgery Department, Istanbul, Turkey.
Karatepe
Oguzhan
O
Arýkan
Soykan
S
Battal
Muharrem
M
Kemik
Ozgur
O
Altiok
Merih
M
Kamali
Gulcin
G
Karahan
Servet
S
D000714:Anastomosis, Surgical; D000818:Animals; D002266:Carboxymethylcellulose Sodium; D003106:Colon / Q000473:pathology / Q000601:surgery*; D005260:Female; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D008567:Membranes, Artificial; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium