title: Diffusion-weighted MRI of urinary bladder and prostate cancers.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the feasibility of diffusion-weighted imaging in the diagnosis of the urinary bladder and prostate carcinomas. The apparent diffusion coefficient (ADC) values of the malignant and normal tissues were correlated.
  
  
  METHODS
  A total of 23 patients with 14 urinary bladder carcinomas and 9 prostate carcinomas, and 50 healthy controls with normal ultrasonographic urinary bladder and prostate gland imaging findings were enrolled in the study. The ADC values were reported as the mean +/- standard deviation. Student's t test was performed to compare the ADC values of the normal and pathological tissues. Diffusion-weighted imaging (DWI) was performed with b factors of 0, 500, and 1000 s/mm(2), and the ADC values of the normal tissues and lesions were calculated.
  
  
  RESULTS
  The mean ADC value of the urinary bladder wall of the control group and bladder carcinomas were (2.08 +/- 0.22 x 10(-3)mm(2)/s) and (0.94 +/- 0.18 x 10(-3)mm(2)/s), respectively. In addition, the ADC values of the normal peripheral (2.07 +/- 0.33 x 10(-3)mm(2)/s), transitional zones (1.46 +/- 0.23 x 10(-3)mm(2)/s) of the prostate, seminal vesicles (2.13 +/- 0.13 x 10(-3)mm(2)/s) and the prostate carcinomas (1.06 +/- 0.17 x 10(-3)mm(2)/s) were calculated. The comparison of mean ADC values of the peripheral-transitional zones of the prostate, normal bladder wall-bladder carcinomas, and peripheral zone prostate carcinomas were statistically significant (P < 0.01).
  
  
  CONCLUSIONS
  The present study demonstrated that ADC measurement has a potential ability to differentiate carcinomas from normal bladder wall and prostate gland.
authors.affiliation: Department of Radiology, University of Yeditepe School of Medicine, Istanbul, Turkey. okilickesmez@yahoo.com
authors.forename: Ozgür
authors.initials: O
authors.lastname: Kiliçkesmez
authors.forename: Tan
authors.initials: T
authors.lastname: Cimilli
authors.forename: Ercan
authors.initials: E
authors.lastname: Inci
authors.forename: Arda
authors.initials: A
authors.lastname: Kayhan
authors.forename: Sibel
authors.initials: S
authors.lastname: Bayramoğlu
authors.forename: Neslihan
authors.initials: N
authors.lastname: Taşdelen
authors.forename: Nevzat
authors.initials: N
authors.lastname: Gürmen
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000175:diagnosis*; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods; D005240:Feasibility Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*