Reaction of Bcl-2-positive splenic cells to glucocorticoids.
Study of the glucocorticoid effects on the counts of Bcl-2-positive cells in various zones of the spleen showed that dexamethasone and prednisolone stimulated migration of apoptosis-resistant cells to the spleen, but their effects on cell distribution in various morphofunctional zones of the spleen were different. The population of Bcl-2-positive cells is divided into morphotypes, differing by location and reaction to glucocorticoids.
Luzicova
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EM
Laboratory of Medical Biology Department, Chuvash State University, Cheboksary, Russia. nema76@mail.ru
Efimova
O A
OA
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D011239:Prednisolone / Q000494:pharmacology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D005938:Glucocorticoids; D019253:Proto-Oncogene Proteins c-bcl-2; D003907:Dexamethasone; D011239:Prednisolone