title: Periodontitis and type 2 diabetes: is oxidative stress the mechanistic link?
abstract: Periodontitis is a common, chronic inflammatory disease initiated by bacteria which has an increased prevalence and severity in patients with type 2 diabetes. Recent studies indicate that the co-morbid presence of periodontitis can, in turn, adversely affect diabetic status and the treatment of periodontitis can lead to improved metabolic control in diabetes patients. Current evidence points to a bidirectional interrelationship between diabetes and inflammatory periodontitis. The importance of oxidative stress-inflammatory pathways in the pathogenesis of type 2 diabetes and periodontitis has recently received attention. Given the bidirectional relationship between these two conditions, this review discusses the potential synergistic interactions along the oxidative stress-inflammation axis common to both type 2 diabetes and periodontitis, and the implications of this relationship for diabetic patients.
authors.affiliation: Dept. of Restorative Dentistry, Cork University Dental School & Hospital, Cork, Ireland. e.allen@ucc.ie
authors.forename: E M
authors.initials: EM
authors.lastname: Allen
authors.forename: J B
authors.initials: JB
authors.lastname: Matthews
authors.forename: R
authors.initials: R
authors.lastname: O'Connor
authors.forename: D
authors.initials: D
authors.lastname: O'Halloran
authors.forename: I L C
authors.initials: IL
authors.lastname: Chapple
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D010518:Periodontitis / Q000150:complications* / Q000378:metabolism / Q000473:pathology