Towards retinoid therapy for Alzheimer's disease.
Alzheimer's disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and age-related changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.
Shudo
K
K
Research Foundation ITSUU Laboratory, Tokyo, Japan. kshudo@itsuu.or.jp
Fukasawa
H
H
Nakagomi
M
M
Yamagata
N
N
D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000150:complications / Q000188:drug therapy; D002454:Cell Differentiation; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy; D007858:Learning; D008954:Models, Biological; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000378:metabolism; D012176:Retinoids / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000502:physiology
D016229:Amyloid beta-Peptides; D014150:Antipsychotic Agents; D018168:Receptors, Retinoic Acid; D012176:Retinoids