Parsing brain activity associated with acupuncture treatment in Parkinson's diseases.
Acupuncture, a common treatment modality within complementary and alternative medicine, has been widely used for Parkinson's disease (PD). Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood-oxygen-level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a significant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia-thalamocortical circuit.
Chae
Younbyoung
Y
Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.
Lee
Hyejung
H
Kim
Hackjin
H
Kim
Chang-Hwan
CH
Chang
Dae-Il
DI
Kim
Kyung-Mi
KM
Park
Hi-Joon
HJ
D015670:Acupuncture Therapy / Q000379:methods*; D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D001931:Brain Mapping; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010300:Parkinson Disease / Q000473:pathology* / Q000628:therapy*; D011597:Psychomotor Performance / Q000502:physiology; D012720:Severity of Illness Index
D010100:Oxygen