title: Longitudinal 4.0 Tesla (31)P magnetic resonance spectroscopy changes in the anterior cingulate and left thalamus in first episode schizophrenia.
abstract: Progressive volumetric losses in schizophrenia may be preceded by abnormal cell membrane metabolism. Longitudinal changes in membrane metabolites were quantified with (31)P MRS in the anterior cingulate and left thalamus of 13 first episode schizophrenic patients and 13 healthy volunteers at baseline and 30 months. Glycerophosphocholine was higher in patients at baseline in the anterior cingulate and glycerophosphoethanolamine was lower in the left thalamus at 30 months compared with patients at baseline and volunteers at 30 months. These observations suggest longitudinal changes in membrane metabolites consistent with a neurodegenerative process in certain cases of schizophrenia.
authors.affiliation: Lawson Health Research Institute, London, Ontario, Canada.
authors.forename: Jodi
authors.initials: J
authors.lastname: Miller
authors.forename: Peter
authors.initials: P
authors.lastname: Williamson
authors.forename: J Eric
authors.initials: JE
authors.lastname: Jensen
authors.forename: Rahul
authors.initials: R
authors.lastname: Manchanda
authors.forename: Ravi
authors.initials: R
authors.lastname: Menon
authors.forename: Richard
authors.initials: R
authors.lastname: Neufeld
authors.forename: Nagalingam
authors.initials: N
authors.lastname: Rajakumar
authors.forename: William
authors.initials: W
authors.lastname: Pavlosky
authors.forename: Maria
authors.initials: M
authors.lastname: Densmore
authors.forename: Betsy
authors.initials: B
authors.lastname: Schaefer
authors.forename: Dick J
authors.initials: DJ
authors.lastname: Drost
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D007839:Functional Laterality; D005997:Glycerylphosphorylcholine / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D010714:Phosphatidylethanolamines / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism; D012559:Schizophrenia / Q000175:diagnosis / Q000378:metabolism*; D013788:Thalamus / Q000378:metabolism*; D013997:Time Factors
chemical_list: D010714:Phosphatidylethanolamines; C002449:glycerophosphoethanolamine; D010758:Phosphorus; D005997:Glycerylphosphorylcholine