Semantic fluency: a sensitive marker for cognitive impairment in children with heavy diarrhea burdens?
One of the most affected cognitive impairments in children who experienced heavy burdens of diarrhea is semantic fluency, the same impairment that is most affected in Alzheimer's dementia. These findings are leading us into provocative genetic studies that may elucidate the evolution of such genetic polymorphisms as the APOE alleles. Alternatively, diarrhea could launch the cognitive deficits that might later progress in neurodegenerative diseases. In addition, they suggest that semantic fluency could provide a simple mean to assess cognitive impairment in impoverished settings so as to determine preventive measures.
Oriá
Reinaldo B
RB
Center for Global Health, Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA, USA. rbo5u@virginia.edu
Costa
Carlos Maurício C
CM
Lima
Aldo A M
AA
Patrick
Peter D
PD
Guerrant
Richard L
RL
D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D003967:Diarrhea / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D044342:Malnutrition / Q000503:physiopathology; D008962:Models, Theoretical; D012680:Sensitivity and Specificity; D013060:Speech