Factors influencing infectious complications after pancreatoduodenectomy.
OBJECTIVE
Rates of postoperative morbidity, particularly infectious complications, remain high after pancreatoduodenectomy.


METHODS
Subjects comprised 101 patients who had undergone pancreatoduodenectomy, analyzed according to presence or absence of infectious postoperative complications. Nineteen perioperative variables were analyzed to identify risk factors associated with postoperative infectious complications.


RESULTS
Postoperative infectious complications occurred in 56 patients (55%); among them 29 had serious infectious morbidity, including bacteremia (13%), intra-abdominal infection (18%) and pneumonia (12%). One patient (1%) died of multiple organ failure subsequent to a severe septic attack. Only body mass index (BMI) differed significantly between patients with and without serious infection. Logistic regression analysis identified BMI >25 as an independent factor for occurrence of serious postoperative infectious complications. BMI >25 was a common risk factor for individual infection, including bacteremia, intra-abdominal infection, and pneumonia. As for the influence of BMI on perioperative parameters, the high BMI significantly affected the operation time. Meanwhile preoperative biliary drainage had no influence on overall and individual infectious morbidities.


CONCLUSIONS
This study demonstrates the need for careful postoperative monitoring in the patient with high BMI.
Su
Zhongxue
Z
Department of Surgery, Shandong Provincial Hospital, Shandong, China.
Koga
Rintaro
R
Saiura
Akio
A
Natori
Takeshi
T
Yamaguchi
Toshiharu
T
Yamamoto
Junji
J
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D011446:Prospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000209:etiology