title: Quantitative spectroscopic imaging with in situ measurements of tissue water T1, T2, and density.
abstract: The use of tissue water as a concentration standard in proton magnetic resonance spectroscopy ((1)H-MRS) of the brain requires that the water proton signal be adjusted for relaxation and partial volume effects. While single voxel (1)H-MRS studies have often included measurements of water proton T(1), T(2), and density based on additional (1)H-MRS acquisitions (e.g., at multiple echo or repetition times), this approach is not practical for (1)H-MRS imaging ((1)H-MRSI). In this report we demonstrate a method for using in situ measurements of water T(1), T(2), and density to calculate metabolite concentrations from (1)H-MRSI data. The relaxation and density data are coregistered with the (1)H-MRSI data and provide detailed information on the water signal appropriate to the individual subject and tissue region. We present data from both healthy subjects and a subject with brain lesions, underscoring the importance of water parameter measurements on a subject-by-subject and voxel-by-voxel basis.
authors.affiliation: Department of Neurology, University of New Mexico, Albuquerque, New Mexico 87131, USA. chuck@unm.edu
authors.forename: C
authors.initials: C
authors.lastname: Gasparovic
authors.forename: H
authors.initials: H
authors.lastname: Neeb
authors.forename: D L
authors.initials: DL
authors.lastname: Feis
authors.forename: E
authors.initials: E
authors.lastname: Damaraju
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: M J
authors.initials: MJ
authors.lastname: Doty
authors.forename: D M
authors.initials: DM
authors.lastname: South
authors.forename: P G
authors.initials: PG
authors.lastname: Mullins
authors.forename: H J
authors.initials: HJ
authors.lastname: Bockholt
authors.forename: N J
authors.initials: NJ
authors.lastname: Shah
mesh_terms: D000465:Algorithms; D001834:Body Water / Q000737:chemistry*; D001923:Brain Chemistry; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D014867:Water / Q000032:analysis*
chemical_list: D014867:Water