title: Relation of nasal air flow to nasal cavity dimensions.
abstract: OBJECTIVE
  To investigate the relationship between nasal cavity dimensions and airflow based on measures of acoustic rhinometry (AR) and peak nasal inspiratory flow (PNIF) in a very large sample of mixed rhinologic and nonrhinologic patients.
  
  
  METHODS
  Clinical survey conducted between 2001 and 2007.
  
  
  METHODS
  Secondary referral ambulatory center and hospital.
  
  
  METHODS
  The study population comprised 2523 consecutive adult patients, mainly white, referred to the Department of Otolaryngology-Head and Neck Surgery, Sørlandet Hospital, Kristiansand, Norway, for evaluation of sleep-related disorders (eg, snoring, sleep apnea) or chronic nasal complaints.
  
  
  METHODS
  The subjects underwent AR and PNIF at baseline and after decongestion of the nasal mucosa with xylometazoline hydrochloride. Questionnaires and height and weight measurements were obtained prior to the nasal recordings.
  
  
  METHODS
  Associations between measures of AR (volume and area) and PNIF.
  
  
  RESULTS
  Nearly linear relationships were found between PNIF in 4 categories and nasal cavity volumes and minimal cross-sectional areas (analysis of variance, P < .001; post hoc analysis, P < .01). Adjusted associations between 5 of 6 AR measures and PNIF both at baseline and after decongestion were significant (P < .001 in 9 cases and P = .03 in 1 case).
  
  
  CONCLUSIONS
  Our study indicates statistically significant associations between nasal cavity dimensions and PNIF. The most important structural determinant for PNIF is the minimal cross-sectional area of the nasal cavity.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Sørlandet Hospital, Serviceboks 416, Kristiansand, Norway. kjaergaard.t@gmail.com
authors.forename: Thomas
authors.initials: T
authors.lastname: Kjaergaard
authors.forename: Milada
authors.initials: M
authors.lastname: Cvancarova
authors.forename: Sverre K
authors.initials: SK
authors.lastname: Steinsvåg
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000328:Adult; D000403:Airway Resistance / Q000502:physiology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D009296:Nasal Cavity / Q000033:anatomy & histology*; D009297:Nasal Mucosa / Q000187:drug effects; D009666:Nose / Q000503:physiopathology*; D023842:Rhinometry, Acoustic; D012891:Sleep Apnea Syndromes / Q000453:epidemiology / Q000503:physiopathology; D012907:Smoking / Q000453:epidemiology; D012913:Snoring / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; C009695:xylometazoline