Cutaneous human papillomavirus in head and neck squamous cell carcinomas.
To evaluate the prevalence and meaning of cutaneous human papillomavirus (HPV) types in HNSCC 51 patients were analyzed for the prevalence of cutaneous as well as mucosal HPV. HPV DNA was demonstrated in 18 (35%) of 51 tumors. The majority of these HPV types belong to so-called cutaneous HPV types, whereas only HPV 6 and HPV 16 were from the mucosal HPV types. A possible role for cutaneous HPV types as co-factors in the oncogenesis of HNSCC remains to be elucidated and may be relevant for future strategies of cancer prevention.
Lindel
Katja
K
Department of Radiation Oncology and Radiotherapy, University of Heidelberg, Heidelberg, Germany. Katja Lindel@med.uni-heidelberg.de
Helmke
Burkhard
B
Simon
Christian
C
Weber
Klaus J
KJ
Debus
Juergen
J
de Villiers
Ethel-Michele
EM
D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D052685:Alphapapillomavirus / Q000145:classification / Q000302:isolation & purification*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000821:virology*; D002472:Cell Transformation, Viral; D003131:Combined Modality Therapy; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000032:analysis; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000821:virology; D009928:Organ Specificity; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence; D012307:Risk Factors; D012867:Skin / Q000821:virology; D012907:Smoking / Q000453:epidemiology
D015344:DNA Probes, HPV; D004279:DNA, Viral; D016190:Carboplatin; D005472:Fluorouracil