Pathophysiology and animal models of schizophrenia.
Animal models of schizophrenia are important for research aimed at developing improved pharmacotherapies. In particular, the cognitive deficits of schizophrenia remain largely refractory to current medications and there is a need for improved medications. We discuss the pathophysiology of schizophrenia and in particular the possible mechanisms underlying the cognitive deficits. We review the current animal models of schizophrenia and discuss the extent to which they meet the need for models reflecting the various domains of the symptomatology of schizophrenia, including positive symptoms, negative symptoms and cognitive symptoms.
Dawe
Gavin S
GS
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Clinical Research Centre, 10 Medical Drive, Singapore.
Hwang
Ern Huei
EH
Tan
Chay Hoon
CH
D000818:Animals; D004358:Drug Therapy; D006801:Humans; D023421:Models, Animal; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*