title: Mesenchymal cell response to nanosized biphasic calcium phosphate composites.
abstract: Biphasic calcium phosphate nanoparticles comprising both hydroxyapatite (HA) and beta polymorph of tricalcium phosphate (beta-TCP) have been synthesized together by a polymer matrix mediated process. The process, based on in situ mineralization of poly (vinyl alcohol), exerts a good control over the morphological features of biphasic nanoparticles. By controlling the reaction chemistry (Ca:P ratios), nanobioceramic particles having three different HA/beta-TCP ratios of 50:50, 55:45 and 60:40 respectively. As the two constituents of biphasic system (HA and beta-TCP) facilitate series of signaling cascades in osteoblast division and differentiation, the adhesion and differentiation properties of mesenchymal cells (MSCs) derived from bone marrow has been studied.
authors.affiliation: National Metallurgical Laboratory, CSIR, Jamshedpur 831 007, India.
authors.forename: Avijit Kumar
authors.initials: AK
authors.lastname: Guha
authors.forename: Shashi
authors.initials: S
authors.lastname: Singh
authors.forename: R
authors.initials: R
authors.lastname: Kumaresan
authors.forename: Suprabha
authors.initials: S
authors.lastname: Nayar
authors.forename: Arvind
authors.initials: A
authors.lastname: Sinha
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000737:chemistry* / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D017886:Durapatite / Q000737:chemistry* / Q000494:pharmacology; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite