title: Dancing Eye Syndrome associated with spontaneous recovery and normal neurodevelopment.
abstract: Five patients with spontaneously recovering Dancing Eye Syndrome/Opsoclonus Myoclonus Syndrome are described. Age at presentation ranged from 4 to 19 months. Four had symptoms of fever and a coryzal illness within days to a few weeks prior to the onset. One of the 4 also had varicella zoster 4 weeks before presentation. All had opsoclonus, myoclonus/ataxia and irritability. Associated infective agents identified were Coxsackie virus and rotavirus. Spontaneous improvement of symptoms started within 9 days of presentation and total duration of illness ranged from 10 to 24 days. Developmental progress at follow-up was normal in all cases. A range of immunomodulatory therapies have been advocated for the treatment of Dancing Eye Syndrome/Opsoclonus Myoclonus Syndrome. However, in some children, early spontaneous recovery may occur, an observation which should be borne in mind when designing therapeutic trials in this condition.
authors.affiliation: Department of Paediatrics, Newcastle General Hospital, Newcastle upon Tyne, UK.
authors.forename: K
authors.initials: K
authors.lastname: Ki Pang
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Lynch
authors.forename: John P
authors.initials: JP
authors.lastname: Osborne
authors.forename: Michael G
authors.initials: MG
authors.lastname: Pike
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D001259:Ataxia / Q000150:complications; D001921:Brain / Q000502:physiology*; D002657:Child Development / Q000502:physiology*; D003384:Coxsackievirus Infections / Q000150:complications / Q000188:drug therapy / Q000821:virology; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D053578:Opsoclonus-Myoclonus Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D020127:Recovery of Function; D012075:Remission, Spontaneous; D012400:Rotavirus Infections / Q000150:complications / Q000188:drug therapy / Q000821:virology
chemical_list: D000890:Anti-Infective Agents; D007155:Immunologic Factors