Pathophysiology of diabetic nephropathy: involvement of multifaceted signalling mechanism.
Diabetic nephropathy is a major cause of end-stage renal failure and the mortality rate due to this disease is continuously progressing worldwide. The multifaceted signalling mechanisms have been identified to be involved in the pathogenesis of diabetic nephropathy. Despite the modern therapies like antidiabetics, antihypertensives, and antioxidants available to treat diabetic nephropathy; most of patients continue to show progressive renal damage. It suggests that the key pathogenic mechanism involved in the induction and progression of diabetic nephropathy is still remaining active and unmodified by the present therapies. The purpose of this review is to bring together the current information concerning the signalling systems involved in the pathogenesis of diabetic nephropathy.
Balakumar
Pitchai
P
Department of Physiology, University of Montreal, CP 6128, Succ. Centreville, Montreal, QC H3C 3J7, Canada. pbala2006@gmail.com
Arora
Mandeep Kumar
MK
Reddy
Jayarami
J
Anand-Srivastava
Madhu B
MB
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D003928:Diabetic Nephropathies / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D018450:Disease Progression; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000503:physiopathology; D015398:Signal Transduction
D000959:Antihypertensive Agents; D000975:Antioxidants; D007004:Hypoglycemic Agents