Clinical outcome of endoscopic submucosal dissection versus endoscopic mucosal resection of large colorectal tumors as determined by curative resection.
OBJECTIVE
Endoscopic submucosal dissection (ESD) has recently been applied to the treatment of superficial colorectal cancer. Clinical outcomes compared with conventional endoscopic mucosal resection (EMR) have not been determined so our aim was to compare the effectiveness of ESD with conventional EMR for colorectal tumors >or=20 mm.


METHODS
This was a retrospective case-controlled study performed at the National Cancer Center Hospital in Tokyo, Japan involving 373 colorectal tumors >or=20 mm determined histologically to be curative resections. Data acquisition was from a prospectively completed database. We evaluated histology, tumor size, procedure time, en bloc resection rate, recurrence rate, and associated complications for both the ESD and EMR groups.


RESULTS
A total of 145 colorectal tumors were treated by ESD and another 228 were treated by EMR. ESD was associated with a longer procedure time (108 +/- 71 min/29 +/- 25 min; p < 0.0001), higher en bloc resection rate (84%/33%; p < 0.0001) and larger resected specimens (37 +/- 14 mm/28 +/- 8 mm; p = 0.0006), but involved a similar percentage of cancers (69%/66%; p = NS). There were three (2%) recurrences in the ESD group and 33 (14%) in the EMR group requiring additional EMR (p < 0.0001). The perforation rate was 6.2% (9) in the ESD group and 1.3% (3) in the EMR group (p = NS) with delayed bleeding occurring in 1.4% (2) and 3.1% (7) of the procedures (p = NS), respectively, as all complications were effectively treated endoscopically.


CONCLUSIONS
Despite its longer procedure time and higher perforation rate, ESD resulted in higher en bloc resection and curative rates compared with EMR and all ESD perforations were successfully managed by conservative endoscopic treatment.
Saito
Yutaka
Y
Endoscopy Division, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. ytsaito@ncc.go.jp
Fukuzawa
Masakatsu
M
Matsuda
Takahisa
T
Fukunaga
Shusei
S
Sakamoto
Taku
T
Uraoka
Toshio
T
Nakajima
Takeshi
T
Ikehara
Hisatomo
H
Fu
Kuang-I
KI
Itoi
Takao
T
Fujii
Takahiro
T
D000230:Adenocarcinoma / Q000601:surgery*; D016022:Case-Control Studies; D003106:Colon / Q000293:injuries; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000601:surgery*; D004396:Coloring Agents; D004210:Dissection / Q000295:instrumentation / Q000379:methods; D006471:Gastrointestinal Hemorrhage / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007203:Indigo Carmine; D007413:Intestinal Mucosa / Q000601:surgery*; D007416:Intestinal Perforation / Q000453:epidemiology / Q000209:etiology; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D019106:Postoperative Hemorrhage / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D016896:Treatment Outcome
D004396:Coloring Agents; D007203:Indigo Carmine