title: Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis.
abstract: The first synthesis of two natural triterpenoid saponins, which were isolated from the roots of Pulsatilla chinensis and exhibited excellent in vitro cytotoxic activity against HL-60 cells, was concisely achieved in a convergent approach. We employed an odourless 2-methyl-5-tert-butylphenyl (Mbp) thioglycoside and trichloroacetimidate donors in one-pot reaction as a key step.
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
authors.forename: Qingchao
authors.initials: Q
authors.lastname: Liu
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Tiantian
authors.initials: T
authors.lastname: Guo
authors.forename: Guokai
authors.initials: G
authors.lastname: Lv
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Li
mesh_terms: D000081:Acetamides; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*; D062845:Chloroacetates; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D018517:Plant Roots / Q000737:chemistry*; D031946:Pulsatilla / Q000737:chemistry*; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*; D013865:Thioglycosides / Q000737:chemistry; D014238:Trichloroacetic Acid / Q000737:chemistry
chemical_list: D000081:Acetamides; D001688:Biological Products; D062845:Chloroacetates; D012503:Saponins; D013865:Thioglycosides; D014238:Trichloroacetic Acid; D009828:Oleanolic Acid; C009528:trichloroacetamide