title: Current concepts in malignant bowel obstruction management.
abstract: Malignant bowel obstruction (MBO) is a challenging complication of advanced cancer. Several pathophysiologic mechanisms are responsible for the syndrome, including mechanical compression, motility disorders, gastrointestinal secretion accumulation, decreased gastrointestinal absorption, and inflammation. The treatment of related symptoms requires a collaborative approach of surgical, interventional, and medical specialists. The surgical approach proves beneficial in selected patients with operable lesions, life expectancy greater than 2 months, and good performance status. Interventionalists place self-expanding metallic stents as a minimally invasive palliative method either as a definitive treatment or as a bridge to surgery. However, most patients with MBO are not candidates for surgery or stent placement. Medical management with opioids, antispasmodics, antiemetics, antisecretory agents, and corticosteroids is effective in controlling the symptoms associated with MBO. This article discusses the current understanding of MBO pathophysiology and emphasizes current MBO management concepts; it then reviews surgical, interventional, and medical approaches.
authors.affiliation: The Institute for Palliative Medicine at San Diego Hospice, 4311 Third Avenue, San Diego, CA 92103, USA. eroeland@sdhospice.org
authors.forename: Eric
authors.initials: E
authors.lastname: Roeland
authors.forename: Charles F
authors.initials: CF
authors.lastname: von Gunten
mesh_terms: D013505:Digestive System Surgical Procedures; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D007415:Intestinal Obstruction / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D009369:Neoplasms / Q000150:complications / Q000628:therapy*; D010166:Palliative Care / Q000379:methods; D015607:Stents; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents