[Nitric oxide synthesis during long-term adaptation to intensive muscular work in female sportsmen].
14 trained and 21 non-trained girls 18-22 years of age have been inspected. We found that systematically trained girls had a higher level of nitric oxide synthesis through calcium-dependent L-arginine oxidation by constitutive NO-synthase isoforms (eNOS, nNOS) and through reduction of stable oxidized NO metabolites. NO synthesized de novo in calcium-dependent pathway provides a long-term organism adaptation to physical loads of high volume and intensity at the beginning and in the middle of stress-aggravated competition period. At the end of competition period we detected significant activation of inducible calcium-independent de novo NO synthesis from L-arginine.
Bohdanovs'ka
N V
NV
Sviatodukh
H M
HM
Kotsiuruba
A V
AV
Korkach
Iu P
IuP
Malikov
M V
MV
D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D001120:Arginine / Q000378:metabolism; D054874:Athletic Performance / Q000502:physiology*; D002118:Calcium / Q000502:physiology; D005260:Female; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000096:biosynthesis*; D052248:Nitric Oxide Synthase Type I / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D009573:Nitrites / Q000097:blood; D013997:Time Factors; D055815:Young Adult
D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D001120:Arginine; C496314:NOS3 protein, human; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III; D002118:Calcium