title: Effects of bee venom treatment on growth performance of young pigs.
abstract: This study examined the effect of whole bee venom (BV) as a potential stimulant of the piglet immune system, on growth performance, blood parameters, plasma protein and immune globulin content of serum. Piglets (n = 97) received combinations of 0.5, 1.0, 1.5, 2.0 and 2.5 mg/kg of parenterally administered BV on 4 occasions between birth and Day 30. In the apipuncture group (n = 31), piglets were acupunctured with the worker honeybee. Two acupoints, GV-1 (Jiao-chao) and GV-20 (Bai-hui), were selected for apipuncture. All piglets (n = 128) in the treatment groups were treated 4 times throughout the study period of 60 days. The control piglets received no treatments. Blood was taken via jugular venipuncture on Day 30 after birth. Body weight and survivability were measured, and changes in hematological values were analyzed. Both the BV injection group and apipuncture group increased body weight and survivability by 26.6% and 21.8%, and 7.9% and 6.7% respectively compared to the controls. The numbers of leukocytes, erythrocytes, lymphocytes and monocytes were not influenced by treatments. However, a potential clinical benefit of high dose therapy was seen in increased populations of leukocytes, lymphocytes and monocytes compared with either the apipuncture or control groups. Other blood parameters such as total protein and albumin were not affected by treatment. However, IgG levels were generally higher in treated groups than in the controls. These findings indicate that BV might be useful to stimulate immuno-competence in pig production, possibly via the primary bioactive components of melittin, phospholipase A(2) and apamin. The administration of BV, either via injection or acupuncture, did not make any differences in growth performance of young pigs. These results would be useful for further purification and characterization of immune boosting agents from BV.
authors.affiliation: Laboratory of Applied Material Science, Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA, Suwon, 441-100, South Korea.
authors.forename: Sang Mi
authors.initials: SM
authors.lastname: Han
authors.forename: Kwang Gill
authors.initials: KG
authors.lastname: Lee
authors.forename: Joo Hong
authors.initials: JH
authors.lastname: Yeo
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Hwang
authors.forename: Chul Ho
authors.initials: CH
authors.lastname: Jang
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Chenoweth
authors.forename: Sok Cheon
authors.initials: SC
authors.lastname: Pak
mesh_terms: D000818:Animals; D001514:Bee Venoms / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects*; D013552:Swine
chemical_list: D001514:Bee Venoms