title: Frozen cyclohexane-in-water emulsion as a sacrificial template for the synthesis of multilayered polyelectrolyte microcapsules.
abstract: This paper reports the application of frozen cyclohexane-in-water emulsions as sacrificial templates for the fabrication of hollow microcapsules through layer-by-layer assembly of polyelectrolytes, poly(styrenesulfonate sodium salt), and poly(allylamine hydrochloride). Extraction of the cyclohexane phase from frozen emulsions stabilized with 11 polyelectrolyte layers by compatibilization with 30% v/v ethanol leads to the formation of water-filled microcapsules while preserving the spherical geometry. The majority of microcapsules (>90%) are prepared with intact polyelectrolyte membranes as measured by their deformation induced by osmotic pressure. This work provides a new route for the synthesis of hollow multilayered microcapsules under mild operating conditions.
authors.affiliation: Center for Co-operative Bioactive Systems, Polytechnic Institute of New York University (NYU-POLY), 6 Metrotech Center, Brooklyn, New York 11201, USA. skhapli@duke.poly.edu
authors.forename: Sachin
authors.initials: S
authors.lastname: Khapli
authors.forename: Jin Ryoun
authors.initials: JR
authors.lastname: Kim
authors.forename: Jin Kim
authors.initials: JK
authors.lastname: Montclare
authors.forename: Rastislav
authors.initials: R
authors.lastname: Levicky
authors.forename: Maurizio
authors.initials: M
authors.lastname: Porfiri
authors.forename: Stavroula
authors.initials: S
authors.lastname: Sofou
mesh_terms: D000327:Adsorption; D002214:Capsules; D003510:Cyclohexanes / Q000737:chemistry*; D004337:Drug Carriers; D004573:Electrolytes; D004655:Emulsions; D000431:Ethanol / Q000737:chemistry; D005615:Freezing; D018613:Microscopy, Confocal / Q000379:methods; D009995:Osmosis; D011312:Pressure; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
chemical_list: D002214:Capsules; D003510:Cyclohexanes; D004337:Drug Carriers; D004573:Electrolytes; D004655:Emulsions; D014867:Water; D000431:Ethanol; C506365:Cyclohexane