Impact of NHC ligand conformation and solvent concentration on the ruthenium-catalyzed ring-closing metathesis reaction.
Two saturated N-heterocyclic carbene ligands with substituted naphthyl side chains were used for the preparation of Blechert-type ruthenium metathesis precatalysts. The resulting conformers of the complexes were separated and unambiguously assigned by X-ray diffraction studies. All new complexes were compared in terms of activity to the original, SIMes-derived Blechert catalyst and were shown to be superior. A study on the impact of solvent concentration in RCM reactions using the most active of these new catalysts ultimately led to the ring closing of a variety of substrates at very low catalyst loadings.
Gatti
Michele
M
Organic Chemistry Institute, University of Zurich (UZH), Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Vieille-Petit
Ludovic
L
Luan
Xinjun
X
Mariz
Ronaldo
R
Drinkel
Emma
E
Linden
Anthony
A
Dorta
Reto
R