[Regulation of PAI-1 expression].
PAI-1 (plasminogen activator inhibitor-1) is a member of plasminogen cascade with an inhibitory role in plasmin activation. Plasmin is a protease capable of acting on wide range of substrates and, together with metaloproteinases, is a main proteolytic enzyme. Except its role in plasminogen cascade, PAI-1 has an affinity to vitronectin and uPA/uPAR what involves PAI-1 in cell's motility. PAI-1 gene is regulated in response to cytokines, hormones and many growth factors among which TGFbeta is the most important one. The PAI-1 promoter contains SBE, CAGA box, HRE, ERE, NFkB - binding sites, Sp-1, AP-1 and other. Cooperation between transcription factors bound to promoter and cross-talks between kinases and other upstream proteins decide about gene expression. This work describes the present knowledge in this field.
Wyrzykowska
Paulina
P
Zakład Biochemii Komórki, Wydział Biofizyki, Biochemii i Biotechnologii, Uniwersytet Jagiel- loński, Kraków. paulinawyrzykowska@tlen.pl
Kasza
Aneta
A
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D004789:Enzyme Activation / Q000235:genetics; D004815:Epidermal Growth Factor / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics* / Q000378:metabolism*
D016207:Cytokines; D017395:Plasminogen Activator Inhibitor 1; D004815:Epidermal Growth Factor; D005341:Fibrinolysin