title: Risk factors for complications after laparoscopic surgery in colorectal cancer patients: experience of 401 cases at a single institution.
abstract: BACKGROUND
  Laparoscopic surgery is widely used for the treatment of colorectal cancer, but little is known about perioperative risk factors for complications.
  
  
  METHODS
  Clinical data were reviewed for 401 consecutive unselected colorectal cancer patients who underwent laparoscopic surgery at Kyoto Medical Center between 1998 and 2005. The outcome variable was incidence of postoperative complications. Using logistic regression analysis, 58 background, clinical, preoperative, and intraoperative factors were assessed as potential predictors of complications.
  
  
  RESULTS
  The set of independent protective factors that had the greatest influence on the incidence of local complications after colon surgery was as follows: cefmetazole use for prophylaxis (versus oral only; adjusted odds ratio (OR) 0.18, 95% confidence interval (CI) 0.06-0.54), high operative infusion rate (per ml/min; OR 0.82, 95% CI 0.70-0.95), regular laxative use (OR 0.33, 95% CI 0.12-0.79), and double-stapled anastomosis (versus hand-sewn; OR 0.15, 95% CI 0.03-0.83). Independent risk factors for local complications after rectal surgery were abdominoperineal resection (versus low anterior resection, OR 4.84, 95% CI 1.64-14.9), long operative time (per hour, OR 1.55, 95% CI 1.11-2.23), and history of heart disease (OR 5.18, 95% CI 1.34-21.5). The occurrence of complications was not found to be associated with overall survival in this study.
  
  
  CONCLUSIONS
  We identified intraoperative management such as low operative infusion rate is one of the independent significant risk factors for complications after laparoscopic surgery for colorectal cancer in addition to patient characteristics and surgical procedure.
authors.affiliation: Division of Gastrointestinal Surgery, Department of Surgery, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. hidakoya@kuhp.kyoto-u.ac.jp
authors.forename: Koya
authors.initials: K
authors.lastname: Hida
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hata
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kuroyanagi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nagayama
authors.forename: Harue
authors.initials: H
authors.lastname: Tada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Teramukai
authors.forename: Masanori
authors.initials: M
authors.lastname: Fukushima
authors.forename: Kinya
authors.initials: K
authors.lastname: Koizumi
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Sakai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015179:Colorectal Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D010535:Laparoscopy; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D012307:Risk Factors; D016896:Treatment Outcome