Changes in the cytokine profile and reduced function of lymphocyte subpopulations in subacute tetrachloromethane poisoning.
Experiments on outbred albino rats showed that subacute poisoning with tetrachloromethane in a total dose of 1.0 LD50 appreciably decreased blood concentrations of cytokines (IFN-gamma, IL-2, IL-4, IL-6, IL-10), reduced the IFN-gamma/IL-4 ratio in comparison with the control, and suppressed the immune reactions, which attests to greater damage to Th1 compared to Th2 lymphocytes.
Zabrodskii
P F
PF
Saratov State Medical University, Russia. pz@renet.com.ru
Kirichuk
V F
VF
Lim
V G
VG
Balashov
S V
SV
Svistunov
A A
AA
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000097:blood* / Q000276:immunology; D005260:Female; D007371:Interferon-gamma / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D008297:Male; D051381:Rats; D018417:Th1 Cells / Q000166:cytology / Q000378:metabolism*; D018418:Th2 Cells / Q000166:cytology / Q000378:metabolism*
D007378:Interleukins; D007371:Interferon-gamma