title: Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI.
abstract: Calf blood flow was measured simultaneously in healthy human subjects (n = 7) during cuff inflation and deflation using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeled perfusion MRI (ASL-MRI). The DCS and ASL-MRI data exhibited highly correlated absolute and relative dynamic flow responses in each individual (p < 0.001). Peak flow variations during hyperemia were also significantly correlated, though more for relative (p = 0.003) than absolute (p = 0.016) flow. Repeated measurement variation was less than 8% for both modalities. The results provide much needed quantitative blood flow validation of the diffuse optical correlation method in humans.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yu
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Floyd
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Jiongjiong
authors.initials: J
authors.lastname: Wang
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh