Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides.
Polyanion-based microbicides have been developed to prevent the sexual transmission of human immunodeficiency virus (HIV). Recent data suggest that polyanions have the capacity to enhance HIV type 1 (HIV-1) replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.
Sonza
Secondo
S
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia.
Johnson
Adam
A
Tyssen
David
D
Spelman
Tim
T
Lewis
Gareth R
GR
Paull
Jeremy R A
JR
Tachedjian
Gilda
G
D019380:Anti-HIV Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D050091:Dendrimers; D000077560:Enfuvirtide; D015700:HIV Envelope Protein gp41 / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009282:Naphthalenesulfonates / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D000071228:Polyelectrolytes; D011107:Polylysine / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D019380:Anti-HIV Agents; D050091:Dendrimers; D000077560:Enfuvirtide; D015700:HIV Envelope Protein gp41; D009282:Naphthalenesulfonates; D010446:Peptide Fragments; D000071228:Polyelectrolytes; D011107:Polylysine; D011108:Polymers; C120231:PRO 2000; C480351:astodrimer