[Oxidant-antioxidant processes in tissues in ischemic and reperfusion damage to the small intestine].
EPR signals of the tissues were registered in experiment on 20 mongrel dogs. Experimental infarction of the small intestine caused death in all 8 dogs (group 1). Tissues of the small intestine and the liver were obtained before and 1, 3, 6 and 9 hours after intestinal ischemia. Twelve dogs of group 2 were exposed to 2-hour ischemia of the small intestine. Intestinal and liver tissues were studied on reperfusion hour 1, 3 and 6. Of 12 animals 7 survived and 5 died. It was found that ischemia and reperfusion in the small intestine result in suppression of cell antioxidant defense, in generation of excessive amount of active oxygen forms, acceleration of lipid peroxidation in hepatic and intestinal tissues. Severe changes in oxidant-antioxidant processes in the liver took part in the dead animals of group 2. It is suggested that free radical production in the liver in ischemia-reperfusion may serve a prognostic sign of survival.
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004285:Dogs; D004578:Electron Spin Resonance Spectroscopy; D007421:Intestine, Small / Q000378:metabolism*; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism*; D016877:Oxidants / Q000378:metabolism*; D015427:Reperfusion Injury / Q000378:metabolism*
D000975:Antioxidants; D016877:Oxidants