Haemophilia A (factor VIII deficiency) in a litter of Weimaraners.
Inherited coagulopathies are reported in a number of dog breeds. However, to date, there is no report of Weimaraners suffering factor VIII deficiency (haemophilia A). We report the discovery of haemophilia A in both males from a single litter of Weimaraners. Haemophilia A in human beings often results from a de novo stochastic mutation. We found no evidence using currently available screening tests of haemophilia A in relatives as far back as three generations making a stochastic mutation possible in this litter.
Dunning
M D
MD
Department of Veterinary Medicine, University ofCambridge, Madingley Road, Cambridge CB3 0ES, UK.
Averis
G F
GF
Pattinson
H
H
Targett
M
M
Cade
S
S
Herrtage
M E
ME
D000818:Animals; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005169:Factor VIII / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006467:Hemophilia A / Q000235:genetics / Q000662:veterinary*; D008297:Male; D009154:Mutation; D010375:Pedigree
D005169:Factor VIII