Cerebral hemodynamics during coronary artery bypass graft surgery: the effect of carotid stenosis.
Carotid stenosis is a frequent coexisting condition in patients undergoing coronary artery bypass graft (CABG) surgery. The impact of carotid stenosis on cerebral perfusion is not fully understood. The purpose of this study was to determine the impact of carotid stenosis on cerebral blood flow velocity in patients undergoing CABG. Seventy-three patients undergoing CABG were prospectively recruited and underwent preoperative Duplex carotid ultrasound to evaluate the degree of carotid stenosis. Intraoperatively, transcranial Doppler ultrasound was used to record the mean flow velocity (MFV) within the bilateral middle cerebral arteries. In addition, during the period of cardiopulmonary bypass, regulators of cerebral hemodynamics such as hematocrit, partial pressure of carbon dioxide and temperature were recorded. The ipsilateral middle cerebral artery mean flow velocity was compared in arteries with and without carotid stenosis using a repeated measures analysis. Seventy-three patients underwent intraoperative monitoring during CABG and 30% (n=22) had carotid stenosis. Overall, MFV rose throughout the duration of CABG including when the patient was on cardiopulmonary bypass. However, there was no significant MFV difference between those arteries with and without stenosis (F=1.2, p=.21). Further analysis during cardiopulmonary bypass, demonstrated that hemodilution and partial pressure of carbon dioxide may play a role in cerebral autoregulation during CABG. Carotid stenosis did not impact mean cerebral blood flow velocity during CABG. The cerebrovascular regulatory process appears to be largely intact during CABG.
Rudolph
James L
JL
Geriatric Research, Education, and Clinical Center, Boston, MA 02130, USA. jrudolph@partners.org
Sorond
Farzaneh A
FA
Pochay
Val E
VE
Haime
Miguel
M
Treanor
Patrick
P
Crittenden
Michael D
MD
Babikian
Viken L
VL
D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D016893:Carotid Stenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D016009:Chi-Square Distribution; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging*; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D011673:Pulsatile Flow; D017585:Ultrasonography, Doppler, Transcranial; D014655:Vascular Resistance
D002245:Carbon Dioxide; D010100:Oxygen