Diffusion-drift modeling of a growing breast cancerous cell.
This paper presents a 2-D model to calculate the electric current densities and the biopotential differences generated due to a breast cancerous cell during the hyperpolarization of the G1/synthesis (G1/S) transition. The proposed model is based on semiconductor diffusion-drift analysis, and aims to understand the biophysics associated with growing breast cancerous cells. The effect of the duration of the G1/S transition, and the diffusivity and the mobility of the cancerous cell boundary is investigated. The results show that shorter G1/S transition durations, and higher diffusivity and mobility at the cell boundary provide higher magnitude of the electric signals.
Hassan
Ahmed M
AM
Department of Electrical Engineering, University of Arkansas, Fayetteville, AR 72701, USA. amhassan@uark.edu
El-Shenawee
Magda
M
D000465:Algorithms; D001943:Breast Neoplasms / Q000473:pathology*; D048708:Cell Growth Processes / Q000502:physiology; D045744:Cell Line, Tumor; D003198:Computer Simulation; D004574:Electromagnetic Fields; D055724:Electrophysiological Phenomena; D005260:Female; D016193:G1 Phase; D006801:Humans; D008954:Models, Biological; D016196:S Phase