title: Prevalence of abnormal bone density of pediatric patients prior to blood or marrow transplant.
abstract: Osteoporosis and osteopenia are long-term side effects of bone marrow transplant (BMT). The purpose of this study was to determine the prevalence of bone mineral density (BMD) abnormalities in pediatric patients prior to BMT. Forty-four pediatric patients were evaluated with DEXA scans. The average Z-score was -0.37. Thirty-six percent had abnormal BMD. Sixty-seven percent of ALL patients had abnormal BMD. Patients with non-malignant diseases were significantly more likely to have abnormal BMD. Patients with ALL had more defects than solid tumor patients. Females had more defects than males. These results demonstrate BMD defects are common in children prior to BMT, especially in patients with ALL.
authors.affiliation: Department of Pediatrics, Eastern Tennessee State University, Johnson City, Tennessee 37614-0578, USA. klopfens@etsu.edu
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Klopfenstein
authors.forename: Julie
authors.initials: J
authors.lastname: Clayton
authors.forename: Robin
authors.initials: R
authors.lastname: Rosselet
authors.forename: Bryce
authors.initials: B
authors.lastname: Kerlin
authors.forename: Amanda
authors.initials: A
authors.lastname: Termuhlen
authors.forename: Thomas
authors.initials: T
authors.lastname: Gross
mesh_terms: D000293:Adolescent; D000328:Adult; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000453:epidemiology*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010024:Osteoporosis / Q000453:epidemiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D015995:Prevalence