Novel amphiphilic hyperbranched poly (amine-ester) copolymers nanoparticles as protein drug delivery.
Novel amphiphilic protein-loaded hyperbranched poly (amine-ester) copolymers nanoparticles were fabricated by double emulsion (DE) and nanoprecipitation (NP) methods. Encapsulation efficiency (EE) of nanoparticles to Bovine serum albumin (BSA) could reach 97.8% at BSA (0.01 g/ml), internal phase volume (0.5 ml), copolymer weight (50mg), and PVA concentration (4%, w/v) condition.
Jiang
Ming
M
National Center for Nanoscience and Technology, Beijing, China.
Wang
Tiewei
T
Xu
Qing
Q
Wu
Yan
Y
D000588:Amines / Q000737:chemistry; D000818:Animals; D002417:Cattle; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D013055:Spectrophotometry, Infrared
D000588:Amines; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D012710:Serum Albumin, Bovine; C033616:poly(lactide)