title: Corneal ulceration due to vitamin A deficiency in Zellweger syndrome.
abstract: We report a case of vitamin A deficiency and secondary corneal ulcer in an infant with Zellweger syndrome. A 7-month-old infant with failure to thrive and malnutrition developed a corneal ulcer. Fortified antibiotic eye drops were administered without improvement. Vitamin A deficiency was suspected and confirmed. Supplementation with oral vitamin A decreased corneal opacification. Zellweger syndrome was later diagnosed. Vitamin A deficiency should be considered in the differential diagnosis of nonhealing corneal ulcers in children, especially those with systemic syndromes and failure to thrive.
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Colburn
authors.forename: Anna S
authors.initials: AS
authors.lastname: Skelo
authors.forename: Sean P
authors.initials: SP
authors.lastname: Donahue
mesh_terms: D000284:Administration, Oral; D003320:Corneal Ulcer / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D014801:Vitamin A / Q000008:administration & dosage; D014802:Vitamin A Deficiency / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014815:Vitamins / Q000008:administration & dosage; D015211:Zellweger Syndrome / Q000150:complications* / Q000175:diagnosis
chemical_list: D014815:Vitamins; D014801:Vitamin A