The influence of class II transactivator and interleukin-6 polymorphisms on the production of antibodies to donor human leucocyte antigen mismatches in renal allograft recipients.
The influence of polymorphisms in the CIITA and IL-6 genes on donor-specific human leucocyte antigen antibody production was investigated in a cohort of renal transplant recipients and their donors. CIITA and IL-6 single nucleotide polymorphisms were found to be associated with donor-specific human leucocyte antigen antibody production post-transplantation.
Martin
J
J
Transplantation Laboratory, Manchester Royal Infirmary, Manchester, UK. jennifer.martin@cmft.nhs.uk
Worthington
J
J
Harris
S
S
Martin
S
S
D000483:Alleles; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics / Q000276:immunology*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics* / Q000276:immunology; D007518:Isoantibodies / Q000096:biosynthesis* / Q000097:blood; D016030:Kidney Transplantation / Q000276:immunology*; D009687:Nuclear Proteins / Q000235:genetics* / Q000276:immunology; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide / Q000235:genetics / Q000276:immunology; D014019:Tissue Donors; D015534:Trans-Activators / Q000235:genetics* / Q000276:immunology
D015850:Interleukin-6; D007518:Isoantibodies; C083728:MHC class II transactivator protein; D009687:Nuclear Proteins; D015534:Trans-Activators