Mortality of patients with renal dysfunction after percutaneous coronary intervention.
OBJECTIVE
To determine the impact of stages of renal dysfunction on mortality after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).


METHODS
A total of 449 patients (mean age 63 +/- 11.9 years) with ACS after PCI were included. Serum creatinine was determined and creatinine clearance was calculated using the Modification of Diet in Renal Disease (MDRD) formula.


RESULTS
The prevalence of chronic kidney disease (CKD) defined as glomerular filtration rate (GFR) <60 mL/min per 1.73 m(2) was 26.3%. After up to 787 days of follow-up, 40 patients had died. Kaplan-Meier survival analysis showed progressively higher risk for cardiovascular death from stage 1 to stage 4 of renal dysfunction. In an adjusted Cox model, gender (P < .009), age (P < .0001), total cholesterol level (P < .01), and stage of renal dysfunction (P < .04) were predictors of mortality.


CONCLUSIONS
In patients with ACS after PCI, a higher stage of renal dysfunction was directly associated with higher mortality of these patients.
Bevc
Sebastjan
S
Clinic for Internal Medicine, Department of Nephrology, University Medical Center, Maribor, Slovenia. sebastjanb@yahoo.com
Penko
Meta
M
Kanic
Vojko
V
Hojs
Radovan
R
D054058:Acute Coronary Syndrome / Q000150:complications*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis