[Stem cells in therapy of multiple sclerosis].
In multiple sclerosis, inflammatory autoimmune response, degeneration of the central nervous system and axonal damage eventually lead to disability. The inflammatory reaction can be controlled with current medication, whereas the neuronal and myelin damage is practically uncontrollable. Cell therapies may provide a new means to prevent nerve cell destruction and promote the regeneration of brain tissue. Bone marrow stem cell transplantation has been used as an immune response modifying therapy in severe MS. Experimental evidence of corrective and protective effects on tissues by preneuronal cells differentiated from fetal and embryonal human stem cells has been obtained in an animal model.
Narkilahti
Susanna
S
Tampereen yliopisto, TAYS, Sekä Solu- ja kudosteknologiakeskus Regea, Biokatu, Tampere.
Hovatta
Outi
O
Elovaara
Irina
I
D000818:Animals; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology / Q000628:therapy*; D033581:Stem Cell Transplantation