title: Increased oxidative stress, decreased total antioxidant capacity, and iron overload in untreated patients with chronic hepatitis C.
abstract: The aim of this study was to determine oxidative stress in patients with untreated chronic hepatitis C (CHC), relating the obtained results with iron status and disease activity markers. Two groups (CHC patients and controls) were studied. CHC patients presented significantly higher values than the control group in some parameters: ALT, AST, GGT, iron, ferritin, and transferrin saturation, and also in tert-butyl hydroperoxide initiate chemiluminescence and thiobarbituric acid-reactive substances (TBARS) as well as lower values in total radical-trapping antioxidant parameter (TRAP). TBARS showed a significant correlation with serum AST and with transferrin saturation, whereas TRAP correlated inversely with serum albumin. Serum ferritin correlated with ALT and GGT, whereas serum iron did so with GGT. In conclusion, lower antioxidant capacity, higher levels of pro-oxidants activity, and iron overload occur in untreated patients with CHC. This greater oxidative activity could play an important role in pathogenesis and evolution of hepatitis C and thus further investigations.
authors.affiliation: Department of Pathology, Clinical Analysis and Toxicology, University of Londrina, Londrina, Paraná, Brazil.
authors.forename: Danielle
authors.initials: D
authors.lastname: Venturini
authors.forename: Andréa Name Colado
authors.initials: AN
authors.lastname: Simão
authors.forename: Décio Sabbatini
authors.initials: DS
authors.lastname: Barbosa
authors.forename: Edson Lopes
authors.initials: EL
authors.lastname: Lavado
authors.forename: Victor Emanuel Soares
authors.initials: VE
authors.lastname: Narciso
authors.forename: Isaias
authors.initials: I
authors.lastname: Dichi
authors.forename: Jane Bandeira
authors.initials: JB
authors.lastname: Dichi
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000975:Antioxidants / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood; D016166:Free Radical Scavengers / Q000097:blood; D019698:Hepatitis C, Chronic / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood; D019190:Iron Overload / Q000097:blood*; D049449:Luminescence; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012709:Serum Albumin / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000097:blood; D020122:tert-Butylhydroperoxide / Q000097:blood
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D012709:Serum Albumin; D017392:Thiobarbituric Acid Reactive Substances; D014168:Transferrin; D005293:Ferritins; D020122:tert-Butylhydroperoxide; D007501:Iron; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase