[Antigenic activity of human herpes virus type 8 proteins coding orfK8.1 and orf65].
A peptide scanning of the sequences of human herpes virus type 8 (HHV-8) proteins coding orfK8.1 and orf65 was made. The antigenic activity of peptides was evaluated by ELISA. The fragment 101-213 aa of orfK8.1-encoded protein was shown to consist of two sites containing linear B-epitopes that had a weak antigenic activity: 121-145 and 177-209 aa. The protein coding orf65 comprised 2 sites at which linear B-cell epitopes 78-110 aa (a weak antigenic activity) and 142-170 aa (a strong antigenic activity) were located.
Kornienko
N V
NV
Pimenov
V K
VK
Gladysheva
M V
MV
Ulanova
T I
TI
Puzyrev
V F
VF
Burkov
A N
AN
Obriadina
A P
AP
D018604:Epitope Mapping; D018985:Epitopes, B-Lymphocyte / Q000737:chemistry / Q000276:immunology*; D006023:Glycoproteins / Q000737:chemistry / Q000276:immunology*; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D010449:Peptide Mapping; D014764:Viral Proteins / Q000737:chemistry / Q000276:immunology*
D018985:Epitopes, B-Lymphocyte; D006023:Glycoproteins; C113454:K8.1 protein, Human herpesvirus 8; C119019:ORF65 protein, human herpesvirus 8; D014764:Viral Proteins