title: The value of mid-trimester routine ultrasonographic screening in antenatal detection of congenital malformations.
abstract: OBJECTIVE
  To evaluate the detection rate of major fetal anomalies by mid-trimester routine ultrasound screening in a single center with low-risk population.
  
  
  METHODS
  The present study was a cross sectional study. All pregnant women attending the antenatal clinic between January 1996 and December 2002 had routine ultrasound screening between 18-22 weeks'gestation. The ultrasonographic results were compared with the pregnancy outcome in aspects of prediction of major fetal anomalies.
  
  
  RESULTS
  Three hundred and sixteen fetuses out of 29,839 (1.06%) had major anomaly. One hundred and forty four fetuses (45.57%) were diagnosed as having major anomaly by routine ultrasound screening. One hundred and seventy two fetuses (54.43%) were undiagnosed. The sensitivity, specificity, positive predictive value, and negative predictive value were 45.57%, 99.97%, 94.74% and 99.42% respectively.
  
  
  CONCLUSIONS
  Although the rate of the detection of major congenital fetal anomaly was low, almost all lethal and life threatening anomalies could be diagnosed antenatally thus allowing the option of counseling, pregnancy termination, or selective referral.
authors.affiliation: Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand. somsri2005p@yahoo.com
authors.forename: Somsri
authors.initials: S
authors.lastname: Pitukkijronnakorn
authors.forename: Apichart
authors.initials: A
authors.lastname: Chittacharoen
authors.forename: Thavat
authors.initials: T
authors.lastname: Jetsawangsri
authors.forename: Panyu
authors.initials: P
authors.lastname: Panburana
authors.forename: Adithep
authors.initials: A
authors.lastname: Jaovisidha
authors.forename: Rasig
authors.initials: R
authors.lastname: Roungsipragarn
authors.forename: Nopadol
authors.initials: N
authors.lastname: Saropala
authors.forename: Yongyuth
authors.initials: Y
authors.lastname: Herabutya
mesh_terms: D000293:Adolescent; D000328:Adult; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging* / Q000235:genetics; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D012680:Sensitivity and Specificity; D013785:Thailand / Q000453:epidemiology; D013997:Time Factors; D016216:Ultrasonography, Prenatal / Q000592:standards*; D055815:Young Adult