Calcium-dependent and endothelium-dependent mechanisms for a constrictor response of the saphenous vein.
Acute experiments on narcotized cats (method of venous resistography) were performed to study a constrictor response of the great saphenous vein in the hindlimb to a bolus intravenous injection of norepinephrine and/or angiotensin II. The saphenous vein exhibited an increased or decreased constrictor response to norepinephrine and angiotensin II, which depended on the order of exposure to adverse factors (calcium channel blocker nifedipine and chemical deendothelialization-inducing agent hemoglobin).
Tsvyashchenko
T Yu
TY
Department for Physiology of Visceral Systems, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St Petersburg, Russia. tatiana_tsvya@yahoo.com
Kudryashov
Yu A
YA
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology; D002415:Cats; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006454:Hemoglobins / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D012501:Saphenous Vein / Q000187:drug effects* / Q000378:metabolism*; D014661:Vasoconstriction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology
D002121:Calcium Channel Blockers; D006454:Hemoglobins; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D002118:Calcium; D009638:Norepinephrine