Modulation of membrane traffic between endoplasmic reticulum, ERGIC and  Golgi to generate compartments for the replication of bacteria and viruses.
Several bacteria and viruses remodel cellular membranes to form compartments specialised for replication. Bacteria replicate within inclusions which recruit membrane vesicles from the secretory pathway to provide nutrients for microbial growth and division. Viruses generate densely packed membrane vesicles called viroplasm which provide a platform to recruit host and viral proteins necessary for replication. This review describes examples where both intracellular bacteria (Salmonella, Chlamydia and Legionella) and viruses (picornaviruses and hepatitis C) recruit membrane vesicles to sites of replication by modulating proteins that control the secretory pathway. In many cases this involves modulation of Rab and Arf GTPases.
Pierini
Roberto
R
Institute of Biomedical and Clinical Sciences, School of Medicine, University of East Anglia, Norfolk NR47TJ, UK.
Cottam
Eleanor
E
Roberts
Rebecca
R
Wileman
Thomas
T
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000254:growth & development* / Q000378:metabolism; D012328:RNA Viruses / Q000502:physiology*; D053586:Virus Internalization; D014779:Virus Replication