title: Synthesis of 4-amino-thiazole analogs of Fmoc-amino acids and thiazole linked N-orthogonally protected dipeptidomimetics.
abstract: We report a one pot synthesis of Fmoc amino acid derived 4-amino-thiazole derivatives and thiazole linked N-orthogonally protected dipeptidomimetics by the condensation of N(alpha)-Fmoc alpha-halomethylketones with thiourea and Boc/Z-alpha-amino acid thioamides via modified Hantzch protocol. Side chain modified Fmoc amino acids containing 4-amino thiazole moiety have also been synthesized following the similar protocol.
authors.affiliation: Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B R Ambedkar Veedhi, Bangalore-560 001, India. hariccb@rediffmail.com
authors.forename: N
authors.initials: N
authors.lastname: Narendra
authors.forename: T M
authors.initials: TM
authors.lastname: Vishwanatha
authors.forename: N S
authors.initials: NS
authors.lastname: Sudarshan
authors.forename: Vommina V
authors.initials: VV
authors.lastname: Sureshbabu
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D005449:Fluorenes / Q000138:chemical synthesis*; D013844:Thiazoles / Q000138:chemical synthesis*
chemical_list: D000596:Amino Acids; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D013844:Thiazoles