title: Antioxidative enzymes and increased oxidative stress in depressive women.
abstract: OBJECTIVE
  To investigate the activities of the main antioxidative enzymes and oxidative stress in women with depressive disorder (DD).
  
  
  METHODS
  In 35 drug-naive women with DD and 35 age matched healthy women enzymes superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPX1), glutathione reductase (GR) and paraoxonase (PON1), concentrations of conjugated dienes (CD), reduced glutathione (GSH) and anthropometric and clinical data were investigated.
  
  
  RESULTS
  Women with DD were found to have decreased activities of GPX1 (p<0.05), decreased concentrations of GSH (p<0.05), and increased activities of GR (p<0.05), CuZnSOD (p<0.001), and concentrations of CD (p<0.05). Activity of GPX1 was positively correlated with concentration of GSH (p<0.05). Concentrations of CD were positively correlated with TG (p<0.01).
  
  
  CONCLUSIONS
  Our set of depressive women was characterized by changes indicating an increased oxidative stress, as well as by certain features of metabolic syndrome.
authors.affiliation: IV. Department of Internal Medicine, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic. jana.kodydkova@seznam.cz
authors.forename: Jana
authors.initials: J
authors.lastname: Kodydková
authors.forename: Lucie
authors.initials: L
authors.lastname: Vávrová
authors.forename: Miroslav
authors.initials: M
authors.lastname: Zeman
authors.forename: Roman
authors.initials: R
authors.lastname: Jirák
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Macásek
authors.forename: Barbora
authors.initials: B
authors.lastname: Stanková
authors.forename: Eva
authors.initials: E
authors.lastname: Tvrzická
authors.forename: Ales
authors.initials: A
authors.lastname: Zák
mesh_terms: D000368:Aged; D000466:Alkadienes / Q000097:blood / Q000737:chemistry; D043303:Aryldialkylphosphatase / Q000097:blood / Q000378:metabolism; D002374:Catalase / Q000097:blood / Q000378:metabolism; D003866:Depressive Disorder / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D004798:Enzymes / Q000097:blood / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D005980:Glutathione Reductase / Q000097:blood / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D000466:Alkadienes; D004798:Enzymes; D014280:Triglycerides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D005978:Glutathione