[Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons].
Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devoted currently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.
Savchenko
H A
HA
Vasylevs'kyĭ
A A
AA
Pluzhnykov
K A
KA
Korol'kova
Iu V
IuV
Mamenko
M V
MV
Volkova
T M
TM
Maksymiuk
O P
OP
Boĭchuk
Ia A
IaA
Hrishyn
Ie V
IeV
Kryshtal'
O O
OO
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured; D018408:Patch-Clamp Techniques; D010446:Peptide Fragments / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D058469:Receptors, Purinergic P2X; D011984:Sensory Receptor Cells / Q000187:drug effects* / Q000378:metabolism; D013111:Spider Venoms / Q000737:chemistry*; D013112:Spiders
D010446:Peptide Fragments; D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; D013111:Spider Venoms