title: [Association Budd Chiari syndrome, antiphospholipid syndrome and Grave's disease].
abstract: BACKGROUND
  Antiphospholipid syndrome is revealed by Budd Chiari syndrome in 5% of the cases. Antiphospholipid syndrome is characterized by venous or arterial thrombosis, foetal loss and positivity of antiphospholipid antibodies, namely lupus anticoagulant, anticardiolipin antibodies and anti-beta2-glycoprotein I. Anticardiolipin antibodies was reported in auto-immune thyroid disorders, particularly in Grave's disease. Antiphospholipid syndrome associated to Grave's disease was reported in only three cases.
  
  
  OBJECTIVE
  To describe a case report of association of Grave's disease and antiphospholipid syndrome.
  
  
  METHODS
  We report the first case of Grave's disease associated with antiphospholipid syndrome, revealed by Budd Chiari syndrome.
  
  
  CONCLUSIONS
  Our observation is particular by the fact that it is about a patient presenting a Grave's disease associated with antiphospholipid syndrome revealed by Budd Chiari syndrome. This triple association has never been reported in literature. Although association between antiphospholipid syndrome and Grave's disease was previously described, further studies evaluating the coexistence of these two affections in the same patient would be useful.
authors.affiliation: Service de Gastro-entérologie, Hôpital Charles Nicolle, Tunis.
authors.forename: Leila
authors.initials: L
authors.lastname: Mouelhi
authors.forename: Mouna
authors.initials: M
authors.lastname: Chaieb
authors.forename: Radhouane
authors.initials: R
authors.lastname: Debbeche
authors.forename: Mohamed
authors.initials: M
authors.lastname: Salem
authors.forename: Imene
authors.initials: I
authors.lastname: Sfar
authors.forename: Sinda
authors.initials: S
authors.lastname: Trabelsi
authors.forename: Yosr
authors.initials: Y
authors.lastname: Gorgi
authors.forename: Taoufik
authors.initials: T
authors.lastname: Najjar
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D006502:Budd-Chiari Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D017809:Fatal Outcome; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology; D008297:Male
chemical_list: D017153:Antibodies, Anticardiolipin; D015415:Biomarkers; D007155:Immunologic Factors