Evolutionary divergence of Plasmodium falciparum: sequences, protein-protein interactions, pathways and processes.
In this article we review the organism-wide biological data available for Plasmodium falciparum (P. falciparum), a malarial parasite, in relation to the data available for other organisms. We provide comparisons at different levels such as amino acid sequences of proteins encoded in the genomes, protein-protein interaction features, metabolic and signaling pathways and processes. Our comparative analyses highlights that P. falciparum is highly diverged compared to most other eukaryotes at all these levels. Despite the extensive variation some of the physical associations between proteins, such as RNA polymerase complex and CDK-cyclin complex are expected to be conserved given their fundamental importance and ubiquitous nature. We also discuss examples of protein-protein interactions across human and P. falciparum potentially happening during pathogenesis.
Tyagi
Nidhi
N
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
Swapna
Lakshmipuram Seshadri
LS
Mohanty
Smita
S
Agarwal
Garima
G
Gowri
Venkatraman Subramanian
VS
Anamika
Krishanpal
K
Priya
Makani Leena
ML
Krishnadev
Oruganty
O
Srinivasan
Narayanaswamy
N
D000595:Amino Acid Sequence; D000818:Animals; D019143:Evolution, Molecular; D006790:Host-Parasite Interactions / Q000235:genetics*; D006801:Humans; D016778:Malaria, Falciparum / Q000235:genetics; D010963:Plasmodium falciparum / Q000235:genetics* / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics* / Q000378:metabolism
D015800:Protozoan Proteins