title: Diabetes does not affect outcome in patients with Enterobacteriaceae bacteremia.
abstract: BACKGROUND
  There is limited information about the effect of diabetes on the prognosis of patients with bacterial infections. We performed a retrospective cohort study to investigate possible correlations between diabetes and prognosis in patients with Enterobacteriaceae bacteremia.
  
  
  METHODS
  We reviewed the medical charts of 1112 patients who were treated at a community teaching hospital for Enterobacteriaceae bacteremia from January 1997 through June 2007. Factors associated with in-hospital mortality were analyzed by logistic regression analysis.
  
  
  RESULTS
  Among the 1112 patients with Enterobacteriaceae bacteremia, 181 (16.3%) were diabetic patients; 90 patients (8.1%) died while in the hospital. Compared to non-diabetic patients, diabetic patients were older (75.4 +/- 11.9 years vs. 70 +/- 16.6 years, p < 0.001) and had more comorbidities. However, mortality among diabetic and non-diabetic patients was not different [7.2% vs. 8.2%, RR 1.13; 95% CI (0.67-1.9); p = 0.39]. In a multivariate analysis, the variables associated with in-hospital mortality were age, the origin of the bacteremia, and the presence of immunosuppression. Diabetes was not associated with outcome.
  
  
  CONCLUSIONS
  In this cohort of patients with Enterobacteriaceae bacteremia, diabetes was not associated with a poorer prognosis.
authors.affiliation: Instituto de Formación e Investigación Marqués de Valdecilla, 39008 Santander, Spain. gpf@mundivia.es
authors.forename: Galo
authors.initials: G
authors.lastname: Peralta
authors.forename: M Blanca
authors.initials: MB
authors.lastname: Sánchez
authors.forename: M Pía
authors.initials: MP
authors.lastname: Roiz
authors.forename: J Carlos
authors.initials: JC
authors.lastname: Garrido
authors.forename: Ramón
authors.initials: R
authors.lastname: Teira
authors.forename: Fátima
authors.initials: F
authors.lastname: Mateos
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology / Q000401:mortality*; D015331:Cohort Studies; D048909:Diabetes Complications / Q000453:epidemiology / Q000382:microbiology; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000382:microbiology*; D004755:Enterobacteriaceae; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000401:mortality*; D005260:Female; D017052:Hospital Mortality; D006784:Hospitals, Teaching / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors