title: Cardiac magnetic resonance imaging in hemodialysis patients.
abstract: BACKGROUND
  The anatomy of left ventricular hypertrophy (LVH) in dialysis patients was studied with magnetic resonance imaging (MRI). Potential benefits of spironolactone were examined in a subset of patients.
  
  
  METHODS
  This was a prospective case series of 30 hemodialysis patients in whom cardiac MRI was performed. Repeat MRI was done in a subset of 13 patients after 9 months of daily oral spironolactone 25 mg.
  
  
  RESULTS
  Subjects exhibited a characteristic cardiac morphology, distinct from both concentric LVH (cLVH) and eccentric LVH (eLVH). Compared with normal controls, LV mass index was increased, end-diastolic volume index was increased, and ejection fraction was reduced, but sphericity indices did not differ. No significant changes were seen after spironolactone.
  
  
  CONCLUSIONS
  LVH in dialysis patients has a unique MRI appearance which is distinct from either cLVH or eLVH, with profound LV thickening and moderate dilation of the ventricular cavity. A 9-month course of spironolactone therapy did not affect morphology.
authors: Division of Nephrology and Hypertension, Allegheny General Hospital, West Penn Allegheny Health System, Pittsburgh, Pennsylvania 15212-4772, USA. rmcgill@wpahs.org
authors: Rita L
authors: RL
authors: McGill
authors: Robert W W
authors: RW
authors: Biederman
authors: Roger T
authors: RT
authors: Getts
authors: Shawn M
authors: SM
authors: Hazlett
authors: Sandeep B
authors: SB
authors: Sharma
authors: Jonathan
authors: J
authors: Duran
authors: Dana E
authors: DE
authors: Brandys
authors: Joshua C
authors: JC
authors: Sysak
authors: Kalathil K
authors: KK
authors: Sureshkumar
authors: S E
authors: SE
authors: Sandroni
authors: R J
authors: RJ
authors: Marcus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects*; D013148:Spironolactone / Q000627:therapeutic use
chemical_list: D013148:Spironolactone