title: Enantioselective addition of phenylacetylene to aldehydes catalyzed by polymer-supported titanium(IV) complexes of beta-hydroxy amides.
abstract: A series of polymer-supported chiral beta-hydroxy amides and C(2)-symmetric beta-hydroxy amides have been synthesized and successfully used for the enantioselective addition of phenylacetylene to aldehydes. High yields (up to 93%) and enantioselectivities (up to 92% ee) were achieved by using polymer-supported chiral beta-hydroxy amide 4b. The resin 4b is reused four times, giving the product with enantioselectivity 80% ee. Fortunately, it is found that this heterogenous system is suitable not only for aromatic aldehydes but also aliphatic aldehyde.
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. huixp@lzu.edu.cn
authors: Xin-Ping
authors: XP
authors: Hui
authors: Lu-Ning
authors: LN
authors: Huang
authors: Ya-Min
authors: YM
authors: Li
authors: Ren-Lin
authors: RL
authors: Wang
authors: Peng-Fei
authors: PF
authors: Xu