title: Fulminant limb and retroperitoneal necrotizing fasciitis in a 15-year-old girl with Fanconi anaemia.
abstract: Necrotizing fasciitis (NF) is an uncommon soft-tissue infection in children that carries a high mortality rate. We present a 15-year-old girl with chronic pancytopenia secondary to Fanconi anaemia who developed extensive NF of the lower limb, which unfortunately resulted in a fatal outcome. Immunodeficiency is a known risk factor for the development of this condition. The findings in this case demonstrate that patients with Fanconi anaemia may be susceptible to NF and that the clinical course may be more aggressive due to underlying immunosuppression. Prompt diagnosis of NF is vital in order to initiate appropriate treatment and to optimize patient outcome. Radiological investigation demonstrated extensive soft-tissue gas and destruction affecting the entire lower limb, abdominal wall and retroperitoneum, which led to timely definitive diagnosis and management.
authors: Department of Radiology, Mercy University Hospital, Cork, Republic of Ireland. kevin.oregan@ucc.ie
authors: Kevin
authors: K
authors: O'Regan
authors: Edward
authors: E
authors: O'Mahony
authors: Peter
authors: P
authors: MacEneaney
authors: Edward
authors: E
authors: Fitzgerald
authors: Michael M
authors: MM
authors: Maher
mesh_terms: D000293:Adolescent; D005199:Fanconi Anemia / Q000150:complications* / Q000000981:diagnostic imaging*; D019115:Fasciitis, Necrotizing / Q000150:complications* / Q000000981:diagnostic imaging*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007866:Leg / Q000000981:diagnostic imaging*; D011859:Radiography; D012187:Retroperitoneal Space / Q000000981:diagnostic imaging*