title: Approaches to seizure risk assessment in preclinical drug discovery.
abstract: Assessment of seizure risk traditionally occurs late in the drug discovery process using low-throughput, resource intensive in vivo assays. Such approaches do not allow sufficient time to mitigate risk by influencing chemical design. Early identification using cheaper, higher throughput assays with lower animal and compound requirements would be preferable. Here we review the current techniques available to assess this issue and describe how they may be combined in a rational step-wise cascade allowing more effective assessment of seizure risk.
authors: Safety Assessment US, AstraZeneca R&D Wilmington, DE 19850, USA. Alison.Easter@astrazeneca.com
authors: Alison
authors: A
authors: Easter
authors: M Elizabeth
authors: ME
authors: Bell
authors: James R
authors: JR
authors: Damewood
authors: William S
authors: WS
authors: Redfern
authors: Jean-Pierre
authors: JP
authors: Valentin
authors: Matthew J
authors: MJ
authors: Winter
authors: Carlos
authors: C
authors: Fonck
authors: Russell A
authors: RA
authors: Bialecki
mesh_terms: D000818:Animals; D019985:Benchmarking / Q000379:methods; D001921:Brain / Q000187:drug effects; D003198:Computer Simulation; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004594:Electrophysiology; D006801:Humans; D018570:Risk Assessment / Q000379:methods*; D012640:Seizures / Q000139:chemically induced*