title: Antimicrobial susceptibility and mutations involved in clarithromycin resistance in Helicobacter pylori isolates from patients in the western central region of Colombia.
abstract: Resistance to metronidazole, clarithromycin, and amoxicillin (amoxicilline) was found in 82, 3.8, and 1.9% of 106 Helicobacter pylori isolates, respectively. No tetracycline-resistant isolates were found. In all of the clarithromycin-resistant isolates, only one point mutation was present, either A2143G or A2142G. Our results indicate that metronidazole should not be included in the empirical treatment of H. pylori infection in this region.
authors: Universidad Tecnológica de Pereira, Facultad de Medicina, Centro de Biología Molecular y Biotecnología, Laboratorio de Microbiología y Parasitología, Pereira, Colombia. adalucyalvarez@utp.edu.co
authors: Adalucy
authors: A
authors: Alvarez
authors: José Ignacio
authors: JI
authors: Moncayo
authors: Jorge Javier
authors: JJ
authors: Santacruz
authors: Mario
authors: M
authors: Santacoloma
authors: Luisa Fernanda
authors: LF
authors: Corredor
authors: Elizabeth
authors: E
authors: Reinosa
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology*; D003105:Colombia; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D000658:Amoxicillin; D013752:Tetracycline; D017291:Clarithromycin