title: Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes.
abstract: A new prenylated dihydroflavonol, 3-hydroxy-kenusanone B 1, as well as three other known isoflavanones, sophoronol 2, sophoraisoflavanone A 3 and kenusanone H 4, were isolated from the rhizomes of Echinosophora koreensis. The structures of these compounds were elucidated using spectroscopic analyses that included extensive 2D NMR, optical rotation spectrometry and mass spectrometry. All four flavonoids enhanced the activities of alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) at micromolar concentrations. Sophoronol 2 showed a nine-fold increased activation of alcohol dehydrogenase and aldehyde dehydrogenase than a negative control group at concentrations of 100 microg/mL and 50 microg/mL, respectively. This study suggests that prenylated flavonoids have the potential to prevent 'hangovers' after alcohol intake.
authors: Korea Institute of Science and Technology, Gangneung Institute, Gangneung 210-340, Korea.
authors: Eun Ju
authors: EJ
authors: Choi
authors: Hak Cheol
authors: HC
authors: Kwon
authors: Young Chang
authors: YC
authors: Sohn
authors: Chun Woo
authors: CW
authors: Nam
authors: Hyun Bong
authors: HB
authors: Park
authors: Cheol Young
authors: CY
authors: Kim
authors: Hyun Ok
authors: HO
authors: Yang
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D004793:Enzyme Reactivators / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D054876:Prenylation; D029909:Sophora / Q000737:chemistry*
chemical_list: C542604:3-hydroxy-kenusanone B; D004793:Enzyme Reactivators; D044948:Flavonols; D007529:Isoflavones; D010936:Plant Extracts; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase