title: Multicenter validation of the magnetic resonance T2* technique for segmental and global quantification of myocardial iron.
abstract: OBJECTIVE
  To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2(*) technique for global and segmental measurement of iron overload in thalassemia patients.
  
  
  METHODS
  Multiecho T2(*) sequences were installed on six MRI scanners. Five healthy subjects (n = 30) were scanned at each site; five thalassemia major (TM) patients were scanned at the reference site and were rescanned locally (n = 25) within 1 month. T2(*) images were analyzed using previously validated software.
  
  
  RESULTS
  T2(*) values of healthy subjects showed intersite homogeneity. On TM patients, for global heart T2(*) values the correlation coefficient was 0.97, coefficients of variation (CoV(s)) ranged from 0.04-0.12, and intraclass coefficients (ICC(s)) ranged from 0.94-0.99. The mean CoV and ICC for segmental T2(*) distribution were 0.198 and 88, respectively.
  
  
  CONCLUSIONS
  The multislice multiecho T2(*) technique is transferable among scanners with good reproducibility.
authors: MRI Laboratory, G Monasterio Foundation and Institute of Clinical Physiology, Pisa, Italy.
authors: Anna
authors: A
authors: Ramazzotti
authors: Alessia
authors: A
authors: Pepe
authors: Vincenzo
authors: V
authors: Positano
authors: Giuseppe
authors: G
authors: Rossi
authors: Daniele
authors: D
authors: De Marchi
authors: Maria Gabriella
authors: MG
authors: Brizi
authors: Antongiulio
authors: A
authors: Luciani
authors: Massimo
authors: M
authors: Midiri
authors: Giuseppina
authors: G
authors: Sallustio
authors: Gianluca
authors: G
authors: Valeri
authors: Vincenzo
authors: V
authors: Caruso
authors: Michele
authors: M
authors: Centra
authors: Paolo
authors: P
authors: Cianciulli
authors: Vincenzo
authors: V
authors: De Sanctis
authors: Aurelio
authors: A
authors: Maggio
authors: Massimo
authors: M
authors: Lombardi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007501:Iron / Q000378:metabolism*; D007558:Italy; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009206:Myocardium / Q000378:metabolism*; D012016:Reference Values; D015203:Reproducibility of Results; D013789:Thalassemia / Q000378:metabolism*
chemical_list: D007501:Iron