title: Asynchronous, out-of-sequence, transcontinental chain kidney transplantation: a novel concept.
abstract: The organ donor shortage has been the most important hindrance in getting listed patients transplanted. Living kidney donors who are incompatible with their intended recipients are an untapped resource for expanding the donor pool through participation in transplant exchanges. Chain transplantation takes this concept further, with the potential to benefit even more recipients. We describe the first asynchronous, out of sequence transplant chain that was initiated by transcontinental shipment of an altruistic donor kidney 1 week after that recipient's incompatible donor had already donated his kidney to the next recipient in the chain. The altruistic donor kidney was transported from New York to Los Angeles and functioned immediately after transplantation. Our modified-sequence asynchronous transplant chain (MATCH) enabled eight recipients, at four different institutions, to benefit from the generosity of one altruistic donor and warrants further exploration as a promising step toward addressing the organ donor shortage.
authors: Department of Surgery, UCLA, Los Angeles, CA, USA.
authors: F K
authors: FK
authors: Butt
authors: H A
authors: HA
authors: Gritsch
authors: P
authors: P
authors: Schulam
authors: G M
authors: GM
authors: Danovitch
authors: A
authors: A
authors: Wilkinson
authors: J
authors: J
authors: Del Pizzo
authors: S
authors: S
authors: Kapur
authors: D
authors: D
authors: Serur
authors: S
authors: S
authors: Katznelson
authors: S
authors: S
authors: Busque
authors: M L
authors: ML
authors: Melcher
authors: S
authors: S
authors: McGuire
authors: M
authors: M
authors: Charlton
authors: G
authors: G
authors: Hil
authors: J L
authors: JL
authors: Veale
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000533:Altruism; D001787:Blood Group Incompatibility; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D009927:Tissue and Organ Procurement; D014184:Transplantation, Homologous; D014481:United States
chemical_list: D000017:ABO Blood-Group System; D003404:Creatinine