Prognostic significance of adipocytokines and extracellular matrix activity in heart failure patients with high B-type natriuretic peptide.
OBJECTIVE
To perform risk stratification by serum adipocytokines and serum markers of extracellular matrix in heart failure patients with high b-type natriuretic peptide (BNP).


METHODS
Patients with heart failure were enrolled in this study. Serum adipocytokines and serum markers of extracellular matrix were analyzed.


RESULTS
In total, 131 patients were enrolled and followed-up for 240+/-174 days. Mortality was significantly associated with adiponectin, resistin, type III amioterminal propeptide of procollagen (PIIINP), matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase 1 (TIMP-1), and serum creatinine. Heart failure-related admission was significantly associated with apelin, and PIIINP. Cox regression analysis identified that mortality and heart failure-related admissions were significantly associated with MMP-2 (P=0.008) and PIIINP (P=0.011), respectively.


CONCLUSIONS
Serum markers of extracellular matrix rather than adipocytokines may warrant further risk stratification for impacting the prognosis of patients with heart failure with high BNP.
Ho
Yi-Lwun
YL
Graduate Institute of Clinical Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Lin
Yen-Hung
YH
Lee
Chi-Ming
CM
Hsu
Ron-Bin
RB
Ting
Hsiu-Tzu
HT
Chou
Nai-Kuan
NK
Chao
Chia-Lun
CL
Wang
Shoei-Shen
SS
Hsu
Hsiu-Ching
HC
Chen
Ming-Fong
MF
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000368:Aged; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000706:statistics & numerical data; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D053208:Kaplan-Meier Estimate; D016014:Linear Models; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood; D011379:Prognosis; D016016:Proportional Hazards Models; D052243:Resistin / Q000097:blood; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood
D054392:Adipokines; D052242:Adiponectin; D010446:Peptide Fragments; D011347:Procollagen; D052243:Resistin; D019715:Tissue Inhibitor of Metalloproteinase-1; C041876:procollagen Type III-N-terminal peptide; D020097:Natriuretic Peptide, Brain; D003404:Creatinine; D020778:Matrix Metalloproteinase 2