title: Results from a prostate cancer admixture mapping study in African-American men.
abstract: There are considerable racial disparities in prostate cancer risk, with a 60% higher incidence rate among African-American (AA) men compared with European-American (EA) men, and a 2.4-fold higher mortality rate in AA men than in EA men. Recently, studies have implicated several African-ancestry associated prostate cancer susceptibility loci on chromosome 8q24. In the current study, we performed admixture mapping in AA men from two independent case-control studies of prostate cancer to confirm the 8q24 ancestry association and also identify other genomic regions that may harbor prostate cancer susceptibility genes. A total of 482 cases and 261 controls were genotyped for 1,509 ancestry informative markers across the genome. The mean estimated individual admixture proportions were 20% European and 80% African. The most significant observed increase in European ancestry occurred at rs2141360 on chromosome 7q31 in both the case-only (P = 0.0000035) and case-control analyses. The most significant observed increase in African ancestry across the genome occurred at a locus on chromosome 5q35 identified by SNPs rs7729084 (case-only analysis P = 0.002), and rs12474977 (case-control analysis P = 0.004), which are separated by 646 kb and were adjacent to one another on the panel. On chromosome 8, rs4367565 was associated with the greatest excess African ancestry in both the case-only and case-control analyses (case-only and case-control P = 0.02), confirming previously reported African-ancestry associations with chromosome 8q24. In conclusion, we confirmed ancestry associations on 8q24, and identified additional ancestry-associated regions potentially harboring prostate cancer susceptibility loci.
authors: Wayne State University School of Medicine, Detroit, MI 48201, USA. bockc@med.wayne.edu
authors: Cathryn Hufford
authors: CH
authors: Bock
authors: Ann G
authors: AG
authors: Schwartz
authors: Julie J
authors: JJ
authors: Ruterbusch
authors: Albert M
authors: AM
authors: Levin
authors: Christine
authors: C
authors: Neslund-Dudas
authors: Susan J
authors: SJ
authors: Land
authors: Angela S
authors: AS
authors: Wenzlaff
authors: David
authors: D
authors: Reich
authors: Paul
authors: P
authors: McKeigue
authors: Wei
authors: W
authors: Chen
authors: Elisabeth I
authors: EI
authors: Heath
authors: Isaac J
authors: IJ
authors: Powell
authors: Rick A
authors: RA
authors: Kittles
authors: Benjamin A
authors: BA
authors: Rybicki
mesh_terms: D000368:Aged; D044383:Black People / Q000235:genetics*; D016022:Case-Control Studies; D002874:Chromosome Mapping / Q000379:methods; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D044465:White People / Q000235:genetics; D001741:Black or African American
chemical_list: D005819:Genetic Markers