title: Diterpenoids from the Mediterranean brown alga Dictyota sp. evaluated as antifouling substances against a marine bacterial biofilm.
abstract: Four new cyclized diterpenes, one xenicane (1) and three dolabellanes (2-4), were isolated, along with seven previously reported metabolites [3beta-hydroxydilophol (5), dictyols E (6) and C (7), hydroxycrenulide (8), 9-acetoxy-15-hydroxy-1,6-dollabelladiene (9), hydroxyacetyldictyolal (10), and fucoxanthin], from a Mediterranean species of Dictyota sp. collected in Le Brusc Lagoon (French Mediterranean coast). Their structures, as well as their relative configurations, were determined through extensive spectrometric (IR, HRESIMS, 1D and 2D NMR) data analysis and molecular modeling studies and by comparison with those reported in literature. Some of the isolated metabolites were evaluated for their antiadhesion activity against a marine bacterial biofilm (Pseudoalteromonas sp. D41).
authors: Universite du Sud Toulon-Var, Avenue de l'Universite, BP 20132, F-83957 La Garde Cedex, France.
authors: Yannick
authors: Y
authors: Viano
authors: Dominique
authors: D
authors: Bonhomme
authors: Mercedes
authors: M
authors: Camps
authors: Jean-François
authors: JF
authors: Briand
authors: Annick
authors: A
authors: Ortalo-Magné
authors: Yves
authors: Y
authors: Blache
authors: Louis
authors: L
authors: Piovetti
authors: Gérald
authors: G
authors: Culioli
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000459:Phaeophyceae / Q000737:chemistry*; D031161:Pseudoalteromonas / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes