title: Development and set-up of a portable device to monitor airway exhalation and deposition of particulate matter.
abstract: The aim of this study was to assess and monitor airway exhalation and deposition of particulate matter (PM). After standardizing inspiratory/expiratory flow and volumes, a novel device was tested on a group of 20 volunteers and in a field study on workers exposed to cristobalite. Both male and female subjects showed a higher percentage of deposition in the 0.5 microm channel than in the 0.3 microm channel on a laser particle counter, but it was higher in the males because of their higher exhaled lung volumes. The device was tested on a wider range of particles (0.3-0.5-1.0-2.5 microm) in the cristobalite productive division. The device has low intrasubject variability and good reproducibility, with geometric mean of %CV < 5%. Such a measure can be used to assess individual susceptibility to PM, making repeated measures in different environments, and examining the persistence of particles in the airways after a period in polluted environments.
authors: Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Parma, Italy.
authors: Matteo
authors: M
authors: Goldoni
authors: Andrea
authors: A
authors: Caglieri
authors: Giuseppe
authors: G
authors: De Palma
authors: Sonia
authors: S
authors: Longo
authors: Olga
authors: O
authors: Acampa
authors: Diana
authors: D
authors: Poli
authors: Paola
authors: P
authors: Manini
authors: Pietro
authors: P
authors: Apostoli
authors: Innocente
authors: I
authors: Franchini
authors: Massimo
authors: M
authors: Corradi
authors: Antonio
authors: A
authors: Mutti
mesh_terms: D000328:Adult; D000388:Air; D004784:Environmental Monitoring / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D045853:Exhalation / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D001239:Inhalation / Q000502:physiology; D019570:Inhalation Exposure; D008297:Male; D016273:Occupational Exposure; D015203:Reproducibility of Results; D012822:Silicon Dioxide / Q000633:toxicity; D014797:Vital Capacity
chemical_list: D012822:Silicon Dioxide