title: Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells.
abstract: Malignant tumors are characterized by dysregulated cell growth and the metastasis of secondary tumors. Numerous studies have documented that osteopontin (OPN) plays a key role in regulating tumor progression and metastasis. Here, we show that the overexpression of OPN in human embryo kidney-293 cells significantly increases both the level of cell proliferation, by provoking the G(1)/S transition, and the level of cell migration in vitro. These findings suggest that augmented OPN contributes to cell growth and motility. Inhibiting OPN or the pathway it stimulates may therefore represent a novel approach for the treatment of primary tumors and associated metastases.
authors: Beijing Jishuitan Hospital, Peking University, Beijing, 100035, PR China. yajun.liu001@gmail.com
authors: Ya-Jun
authors: YJ
authors: Liu
authors: Dao-Qiang
authors: DQ
authors: Zhang
authors: Xiu-Mei
authors: XM
authors: Sui
authors: Wei
authors: W
authors: Tian
mesh_terms: D002453:Cell Cycle; D002460:Cell Line; D002465:Cell Movement; D049109:Cell Proliferation; D015870:Gene Expression; D006801:Humans; D007668:Kidney / Q000166:cytology* / Q000196:embryology / Q000378:metabolism*; D053495:Osteopontin / Q000235:genetics / Q000378:metabolism*
chemical_list: D053495:Osteopontin