Evaluation of neo-angiogenesis in a case of chordoid meningioma.
Chordoid is a rare variant of meningioma that displays a high recurrence rate. In this study we evaluated the immunohistochemical expression of factors that regulate the neo-angiogenesis process in a case of chordoid meningioma with an adverse clinical course. A high microvessel density (MVD), as well as high VEGF and VEGF-R1 expression, was encountered in this tumor. By contrast, the anti-angiogenic factor semaphorin3A, highly expressed in this chordoid meningioma, was ineffective because of the absence of its receptor neuropilin-1. We suggest that VEGF expression and MVD may represent significant prognostic factors in chordoid meningiomas.
Barresi
Valeria
V
Department of Human Pathology, University of Messina, Messina, Italy. vbarresi@unime.it.|Department of Human Pathology, Policlinico Universitario G. Martino, Pad D, Via Consolare Valeria, 98125, Messina, Italy. vbarresi@unime.it.
Tuccari
Giovanni
G
Department of Human Pathology, University of Messina, Messina, Italy.
D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D001706:Biopsy; D000071063:Endoglin; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000473:pathology*; D039942:Neuropilin-1 / Q000378:metabolism; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000378:metabolism; D040121:Semaphorin-3A / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; C108639:SEMA3A protein, human; D040121:Semaphorin-3A; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D039942:Neuropilin-1