Adult B lymphoblastic leukaemia/lymphoma with hypodiploidy (-9) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia - case report and review of literature.
Patients suffering from adult acute lymphoblastic leukemia are acutely ill and present most commonly with fever, pallor, bleeding, lymphadenopathy, hepatosplenomegaly and presence of lymphoblasts in the peripheral blood and bone marrow. We describe a rare presentation of acute lymphoblastic leukemia, in a young adult male who had vague and minimal symptoms with mild splenomegaly. There was severe eosinophilia along with absence of blasts in the peripheral blood, and 40% blasts with increase in eosinophils in the bone marrow. The blasts were positive for common precursor B cell markers on flow cytometry. The patient had a unique cytogenetic abnormality t(7;12)(q22;p13),-9, not previously described in acute lymphoblastic leukemia. He was categorized as poor risk due to failure to achieve complete remission after induction with UK ALL XII chemotherapy.
Bhatti
Farhat Abbas
FA
Department of Haematology, PNS Shifa Hospital, Karachi, Pakistan. farhatab@hotmail.com
Hussain
Iftikhar
I
Ali
Muhammad Zafar
MZ
D000328:Adult; D002881:Chromosomes, Human, Pair 12; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D004171:Diploidy; D004802:Eosinophilia / Q000150:complications* / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic