title: Antigenic variation: extending the reach of telomeric silencing.
abstract: Immune evasion in the parasitic African trypanosome relies upon the silencing of variant surface glycoprotein genes that are found adjacent to telomeres. Work on the RAP1 telomere-binding protein now indicates that silencing spreads over a sufficient distance to repress these genes.
authors: London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. david.horn@lshtm.ac.uk
authors: David
authors: D
authors: Horn
mesh_terms: D000818:Animals; D000940:Antigenic Variation / Q000235:genetics*; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006801:Humans; D016615:Telomere / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000235:genetics / Q000378:metabolism; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000235:genetics / Q000276:immunology
chemical_list: D034501:Telomere-Binding Proteins; D014643:Variant Surface Glycoproteins, Trypanosoma