TEL me all.
Genetically engineered mouse models are powerful systems for dissecting the process of human leukemogenesis. In this issue of Cell Stem Cell, Schindler et al. (2009) describe the elegant use of this approach to dissect, but not completely replicate, the multistep pathogenesis of TEL-AML1(+) leukemia.
Sloma
Ivan
I
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada.
Eaves
Connie J
CJ
D000818:Animals; D030801:Animals, Genetically Modified; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D051379:Mice; D023421:Models, Animal; D050596:Oncogene Fusion; D015514:Oncogene Proteins, Fusion / Q000235:genetics* / Q000378:metabolism; D009857:Oncogenes; D000097764:ETS Translocation Variant 6 Protein
D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein