Effects of a cognitive modulator in the theta and alpha asymmetry during a typewriting task: a sensorimotor integration perspective.
This study aimed to elucidate cortical mechanisms and to identify the areas where occur such mechanisms due to interaction between bromazepam and motor learning. The sample was composed of 45 healthy subjects randomly distributed in 3 groups: placebo (n=15), bromazepam 3 mg (n=15) or bromazepam 6 mg (n=15). To perform the experimental task, subjects sat comfortably at a distance of approximately 20 cm from the typewriter. The typewriter keyboard was covered with a wooden box to avoid visual information about the hands' position. The typewriting task was performed concomitantly with EEG recording. ANOVA two-way results indicated a decreased asymmetry in sensorimotor areas in the experimental groups. Our interpretation is that moderate doses of bromazepam may improve performance on tasks with predictable elements to promote stability of psychomotor functions, but may also impair performance on tasks executed in unpredictable environments.
Cunha
Marlo
M
Institute of Psychiatry, Federal University of Rio de Janeiro, RJ, Brazil. marlo.marques@bol.com.brArq
Machado
Sergio
S
Miana
Luiz Cláudio
LC
Machado
Dionis
D
Bastos
Victor Hugo
VH
Velasques
Bruna
B
Cagy
Maurício
M
Basile
Luis F
LF
Piedade
Roberto
R
Ribeiro
Pedro
P
D000328:Adult; D000704:Analysis of Variance; D001960:Bromazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D007839:Functional Laterality / Q000187:drug effects* / Q000502:physiology; D018757:GABA Modulators / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects* / Q000502:physiology; D055815:Young Adult
D018757:GABA Modulators; D001960:Bromazepam