SKP-ing TAp63: stem cell depletion, senescence, and premature aging.
The p53 family member p63 comprises multiple isoforms and is critical for stratified epithelial development. In this issue of Cell Stem Cell, by generating isoform-specific knockout mice, Su et al. (2009) reveal pivotal roles for TAp63 in the maintenance of dermal and epidermal precursors, genomic stability, and organismal longevity.
Beaudry
Veronica G
VG
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Attardi
Laura D
LD
D019588:Aging, Premature / Q000209:etiology* / Q000235:genetics; D000818:Animals; D016922:Cellular Senescence / Q000235:genetics; D051379:Mice; D010750:Phosphoproteins / Q000235:genetics / Q000502:physiology*; D012867:Skin / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*
D010750:Phosphoproteins; D015534:Trans-Activators; C486419:Trp63 protein, mouse