title: Covalent insertion of antioxidant molecules on chitosan by a free radical grafting procedure.
abstract: In this work, the synthesis of gallic acid-chitosan and catechin-chitosan conjugates was carried out by adopting a free radical-induced grafting procedure. For this purpose, an ascorbic acid/hydrogen peroxide redox pair was employed as radical initiator. The formation of covalent bonds between antioxidant and biopolymer was verified by performing UV, FT-IR, and DSC analyses, whereas the antioxidant properties of chitosan conjugates were compared with that of a blank chitosan, treated in the same conditions but in the absence of antioxidant molecules. The good antioxidant activity shown by functionalized materials proved the efficiency of the reaction method.
authors: Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende, CS 87036, Italy.
authors: Manuela
authors: M
authors: Curcio
authors: Francesco
authors: F
authors: Puoci
authors: Francesca
authors: F
authors: Iemma
authors: Ortensia Ilaria
authors: OI
authors: Parisi
authors: Giuseppe
authors: G
authors: Cirillo
authors: Umile Gianfranco
authors: UG
authors: Spizzirri
authors: Nevio
authors: N
authors: Picci
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002392:Catechin / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry*; D005707:Gallic Acid / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D005707:Gallic Acid; D002392:Catechin; D048271:Chitosan; D006861:Hydrogen Peroxide; D001205:Ascorbic Acid