Photosensitizer efficiency in genetically modified protein cage architectures.
A Ru(bpy)(3)(2+) photosensitizer was covalently linked at specific sites on the interior or exterior surface of genetic constructs of a small heat shock protein cage nanoplatform and the light activated production of singlet oxygen was characterized.
Varpness
Zachary
Z
Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, USA. tdouglas@chemistry.montana.edu.
Suci
Peter A
PA
Ensign
Daniel
D
Young
Mark J
MJ
Douglas
Trevor
T
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D019843:Archaeal Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D056831:Coordination Complexes; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D017017:Methanococcus / Q000378:metabolism; D008958:Models, Molecular; D009154:Mutation; D017319:Photosensitizing Agents / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D017382:Reactive Oxygen Species / Q000378:metabolism; D017975:Ruthenium Compounds
D015082:2,2'-Dipyridyl; D019843:Archaeal Proteins; D056831:Coordination Complexes; D006360:Heat-Shock Proteins; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; C547232:tris(2,2-bipyridine)-ruthenium(II); D017975:Ruthenium Compounds