title: Trypanosoma cruzi: antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro.
abstract: American trypanosomiasis (Chagas disease) continues to be a significant public health problem, and the therapeutic potential of current antichagasic agents (nifurtimox and benznidazole) is rather limited. Here we report on the antitrypanosomal effect of 1-methoxyspirobrassinol and other indole phytoalexins--secondary metabolites produced by Cruciferous plants. These compounds, that previously demonstrated antimicrobial and anticancer properties, displayed significant antiproliferative effects on intracellular amastigotes of Trypanosoma cruzi and may be prospective candidates for antichagasic drug design and development.
authors: Georgia Institute of Technology, School of Biology, Cherry Emerson Building, 310 Ferst Drive, Atlanta, GA 30332, USA. rmezencev3@gatech.edu
authors: Roman
authors: R
authors: Mezencev
authors: Melina
authors: M
authors: Galizzi
authors: Peter
authors: P
authors: Kutschy
authors: Roberto
authors: R
authors: Docampo
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D032446:Myoblasts / Q000187:drug effects / Q000469:parasitology; D051381:Rats; D012717:Sesquiterpenes; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000494:pharmacology*; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D013859:Thiocarbamates / Q000737:chemistry / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects*; D000094162:Phytoalexins
chemical_list: C497735:1-methoxyspirobrassinin; D000981:Antiprotozoal Agents; D007211:Indoles; D012717:Sesquiterpenes; D013141:Spiro Compounds; D013729:Terpenes; D013844:Thiazoles; D013859:Thiocarbamates; C417935:spirobrassinin; C089020:brassinin; D000094162:Phytoalexins