title: Pulmonary adenocarcinoma with heterotopic ossification.
abstract: Pulmonary adenocarcinoma is a common malignancy that often involves calcification; however, bone formation in primary lung adenocarcinoma is extremely rare. In ten cases of primary pulmonary adenocarcinoma with heterotopic ossification, we detected immunoreactivity against TGF-beta1, osteopontin, osteocalcin and Runx2 in the fibroblastic stroma and tumor cells within the area of ossification. Our results suggest that in primary pulmonary adenocarcinoma, heterotopic ossification occurs via intramembranous bone formation. To our knowledge, only 11 other cases of pulmonary adenocarcinoma with heterotopic ossification have been reported. Here, we present ten cases of pulmonary adenocarcinoma showing heterotopic ossification with a description of previously published results and the histogenesis of heterotopic bone formation.
authors: Department of Pathology, East-West Neo Medical Center, College of Medicine, Kyung Hee University, Seoul, Korea.
authors: Gou Young
authors: GY
authors: Kim
authors: Jhingook
authors: J
authors: Kim
authors: Tae Sung
authors: TS
authors: Kim
authors: Joungho
authors: J
authors: Han
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D050659:Core Binding Factor Alpha 1 Subunit / Q000378:metabolism; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000175:diagnosis* / Q000473:pathology; D015675:Osteocalcin / Q000378:metabolism; D053495:Osteopontin / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D050659:Core Binding Factor Alpha 1 Subunit; C493709:RUNX2 protein, human; D053773:Transforming Growth Factor beta1; D015675:Osteocalcin; D053495:Osteopontin