P53 Arg72Pro polymorphism in gastric cancer patients.
BACKGROUND
Polymorphism in codon 72, exon 4 of p53 may alter apoptosis and cancer progression.


METHODS
P53 Arg72Pro genotype was assessed by PCR from 84 gastric cancer patients and 185 controls. The control group was comparable in sex, race, age, smoking, and alcohol intake to the cancer group.


CONCLUSIONS
There was no difference among the frequency of the alleles or genotypes between the groups. P53 Pro/Pro was associated to a lower risk of metastatic disease (p = 0.02) but not to lymph nodes metastasis or worst prognosis. Arg/Arg or Arg/Pro genotype may be associated to metastatic disease.
Gomes de Souza
Lessileia
L
Oncology Group, Medicine Department, Universidade Federal de Sao Paulo (UNIFESP/EPM), São Paulo, Brazil. lessileia@gmail.com
Miranda de Lima
Jacqueline
J
Dale Cotrim Guerreiro da Silva
Ismael
I
Manoukian Forones
Nora
N
D017209:Apoptosis / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53