Polymer-peptide block copolymers - an overview and assessment of synthesis methods.
Incorporating peptide blocks into block copolymers opens up new realms of bioactive or smart materials. Because there are such a variety of peptides, polymers, and hybrid architectures that can be imagined, there are many different routes available for the synthesis of these chimera molecules. This review summarizes the contemporary strategies in combining synthesis techniques to create well-defined peptide-polymer hybrids that retain the vital aspects of each disparate block. Living polymerization can be united with the molecular-level control afforded by peptide blocks to yield block copolymers that not only have precisely defined primary structures, but that also interact with other (bio)molecules in a well defined manner.
Robson Marsden
Hana
H
Department of Soft Matter Chemistry, Leiden Institute of Chemistry, Leiden University, 2300RA Leiden, The Netherlands.
Kros
Alexander
A
D000595:Amino Acid Sequence; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D017433:Protein Structure, Secondary; D012996:Solutions / Q000737:chemistry
D010455:Peptides; D011108:Polymers; D012996:Solutions