title: Differential diagnosis and treatment of primary, cutaneous, anaplastic large cell lymphoma: not always an easy task.
abstract: Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a rare and distinct neoplasm appearing de novo on the skin. We present a case of a 75-year-old man diagnosed with PC-ALCL in his left femoral region. We describe the morphology of lesions along with the differential diagnosis, treatment, clinical course and prognosis. We further discuss parameters concerning treatment that should be considered when a PC-ALCL is diagnosed. Our case report demonstrates the complexity in classification, staging, differential diagnosis and therapy selection of PC-ALCLs. It is crucial to emphasize the importance of clinical criteria in diagnosing a PC-ALCL in combination with immunohistochemistry.
authors: Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece. diamantidis79@yahoo.gr.
authors: Michael D
authors: MD
authors: Diamantidis
authors: Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
authors: Athanasios
authors: A
authors: Papadopoulos
authors: Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
authors: Georgia
authors: G
authors: Kaiafa
authors: Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
authors: George
authors: G
authors: Ntaios
authors: Department of Pathology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Georgia
authors: G
authors: Karayannopoulou
authors: Department of Pathology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors: Ioannis
authors: I
authors: Kostopoulos
authors: Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
authors: Fotios
authors: F
authors: Girtovitis
authors: Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
authors: Zoi
authors: Z
authors: Saouli
authors: Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
authors: Zisis
authors: Z
authors: Kontoninas
authors: Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
authors: Ioannis D
authors: ID
authors: Raptis
authors: Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
authors: Christos
authors: C
authors: Savopoulos
authors: Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
authors: Apostolos
authors: A
authors: Hatzitolios
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone