title: [The expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding].
abstract: OBJECTIVE
  To research the expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding.
  
  
  METHODS
  Detecting the expression of Bcl-2 and Bax protein in 40 cases of endometrium tissue of dysfunctional uterine bleeding patients with immunohistochemistry antibiotics protein-peroxide emzyme (SP)methods.
  
  
  RESULTS
  (1) The expression of Bcl-2 protein changes clearly and periodically in endometrium in normal cycle, the difference is obvious (P < 0.05). (2) The Bcl-2 protein develops with the hyperplasia in endometrium and the expression intensity is enhanced, the difference is obvious( P < 0.05). (3) The expression of Bax gene is masculine in endometrium in normal menstrual cycle. (4) The expression of Bax gene descends gradually with hyperplasia in uterine endometrium (P < 0.05).
  
  
  CONCLUSIONS
  Apoptosis of endometrium cell is restrained from the excessive expression of Bcl-2 protein and deficient expression of Bax protein, so the uterine endometrium gets to hyperplasia or notypical hyperplasia.
authors: The Hospital of Heilongliang Provine, Harbin 150036, China. lily_72_65@chinaren.com.cn
authors: Li-li
authors: LL
authors: Zhou
authors: Li-na
authors: LN
authors: Yang
authors: Li
authors: L
authors: Wang
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology*; D008796:Metrorrhagia / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology; D051028:bcl-2-Associated X Protein / Q000378:metabolism*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein