Loss of NF-kappaB control and repression of Prdx6 gene transcription by reactive oxygen species-driven SMAD3-mediated transforming growth factor beta signaling.
Fatma
Nigar
N
Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Kubo
Eri
E
Takamura
Yoshihiro
Y
Ishihara
Keiichi
K
Garcia
Claudia
C
Beebe
David C
DC
Singh
Dhirendra P
DP
D000818:Animals; D001483:Base Sequence; D015153:Blotting, Western; D002460:Cell Line; D003593:Cytoplasm / Q000378:metabolism; D024202:Electrophoretic Mobility Shift Assay; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D016328:NF-kappa B / Q000378:metabolism*; D018384:Oxidative Stress; D054465:Peroxiredoxin VI / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D015531:Radioimmunoprecipitation Assay; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*; D051900:Smad3 Protein / Q000235:genetics / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D016328:NF-kappa B; D017382:Reactive Oxygen Species; D051900:Smad3 Protein; D016212:Transforming Growth Factor beta; D054465:Peroxiredoxin VI