Reflections on miR-ing effects in metastasis.
In a recent issue of Cell, Valastyan et al. demonstrate that miR-31 can regulate multiple steps in the metastatic cascade independent of confounding effects on primary tumor development. These data have potential to provide biomarkers for prognosis and novel targets for intervention in this most lethal aspect of malignancy.
Dumont
Nancy
N
Department of Pathology, University of California at San Francisco, San Francisco, CA 94143, USA.
Tlsty
Thea D
TD
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D001940:Breast / Q000502:physiology; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D009362:Neoplasm Metastasis / Q000235:genetics*; D016019:Survival Analysis
C534612:MIRN31 microRNA, human; D035683:MicroRNAs