title: Image reconstruction in quantitative X-ray phase-contrast imaging employing multiple measurements.
abstract: X-ray phase-contrast imaging is a technique that aims to reconstruct the projected absorption and refractive index distributions of an object. One common feature of reconstruction formulas for phase-contrast imaging is the presence of isolated Fourier domain singularities, which can greatly amplify the noise levels in the estimated Fourier domain and lead to noisy and/or distorted images in spatial domain. In this article, we develop a statistically optimal reconstruction method that employs multiple (>2) measurement states to mitigate the noise amplification effects due to singularities in the reconstruction formula. Computer-simulation studies are carried out to quantitatively and systematically investigate the developed method, within the context of propagation-based X-ray phase-contrast imaging. The reconstructed images are shown to possess dramatically reduced noise levels and greatly enhanced imaging contrast.
authors: Cheng-Ying
authors: CY
authors: Chou
authors: Yin
authors: Y
authors: Huang
authors: Daxin
authors: D
authors: Shi
authors: Mark A
authors: MA
authors: Anastasio