The animal rule and emerging infections: the role of clinical pharmacology in determining an effective dose.
Bergman
K L
KL
Center for Drug Evaluation and Research, Office of Translational Sciences, Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, Maryland, USA. kimberly.bergman@fda.hhs.gov
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000382:microbiology; D012107:Research Design / Q000331:legislation & jurisprudence*; D014481:United States; D014486:United States Food and Drug Administration
D000890:Anti-Infective Agents