Indications for combined liver and kidney transplantation in children.
A significant number of patients awaiting liver transplantation have associated renal failure and renal dysfunction is associated with increased morbidity and mortality after LT. There has been a recent increase in the number of CLKT in adults. The common indications for CLKT in children are different from those of adults and include metabolic diseases affecting the kidney with or without liver dysfunction and congenital developmental abnormalities affecting both organs. The results are generally encouraging among these groups of patients. Early evaluation and listing of patients before they become severely ill or have major systemic manifestations of their metabolic problem are important.
Chava
Srinivas P
SP
Institute of Liver Studies, Kings College London School of Medicine, King's College Hospital, London, UK.
Singh
Balbir
B
Pal
Sujoy
S
Dhawan
Anil
A
Heaton
Nigel D
ND
D002648:Child; D006085:Graft Survival; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000628:therapy; D015994:Incidence; D007668:Kidney / Q000002:abnormalities; D007674:Kidney Diseases / Q000601:surgery / Q000628:therapy*; D016030:Kidney Transplantation / Q000379:methods*; D008099:Liver / Q000002:abnormalities; D008107:Liver Diseases / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods*; D008765:Methylmalonyl-CoA Mutase / Q000172:deficiency; D010372:Pediatrics / Q000379:methods; D016896:Treatment Outcome
D008765:Methylmalonyl-CoA Mutase