Treating depression and pain.
Although chronic pain and depression have a high co-occurrence, major depression is underrecognized and undertreated in patients with chronic pain conditions, partly because these patients frequently present with somatic complaints rather than mood symptoms. Depression and pain have overlapping neurobiologic mechanisms, and a comprehensive treatment plan for patients with depression and painful physical symptoms should include pharmacotherapy to target serotonergic and noradrenergic neurotransmitters, along with cognitive-behavioral therapy, exercise, and patient education.
Greden
John F
JF
Depression Center, Molecular and Behavioral Neuroscience Institute, and Department of Psychiatry, University of Michigan Health System, Ann Arbor, MI, USA.
D000928:Antidepressive Agents / Q000627:therapeutic use; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000628:therapy*; D015444:Exercise; D006801:Humans; D010146:Pain / Q000523:psychology*; D059408:Pain Management; D010353:Patient Education as Topic; D013001:Somatoform Disorders / Q000628:therapy
D000928:Antidepressive Agents