title: Diagnostic accuracy of 64-slice multidetector CT for detection of in-stent restenosis in an unselected, consecutive patient population.
abstract: OBJECTIVE
  To investigate the diagnostic accuracy of 64-slice multidetector computed tomography (64-CT) for detection of in-stent restenosis (ISR) in an unselected, consecutive patient population.
  
  
  BACKGROUND
  Detection of in-stent restenosis by cardiac CT would be a major advance for the evaluation of patients suspected of having ISR. However, the diagnostic accuracy of current generation 64-CT in this context is not fully established.
  
  
  METHODS
  We conducted a prospective study on patients with stable angina or acute coronary syndrome with no prior history of coronary artery disease. Six months after percutaneous coronary intervention (PCI) with stent placement they underwent a 64-CT scan (Toshiba Multi-Slice Aquilion 64) and consequently a repeat coronary angiography for comparison. Cardiac CT data sets were analyzed for the presence of in-stent restenosis by two independent expert readers blinded to the coronary angiographic data.
  
  
  RESULTS
  Ninety-three patients with a total of 140 stents were evaluated. Males comprised 82% of the study group and the mean age was 63±10 years. The mean time from PCI to the repeat coronary angiography was 208±37 days and the mean time from 64-CT to repeat coronary angiography was 3.7±4.9 days. The restenosis rate according to coronary angiography was 26%. Stent diameter, strut thickness, heart rate and body mass index (BMI) significantly affected image quality. The sensitivity, specificity, positive and negative predictive values of 64-CT for detection of in-stent restenosis were 27%, 95%, 67% and 78%, respectively.
  
  
  CONCLUSIONS
  Current generation, 64-slice CT, remains limited in its ability to accurately detect in-stent restenosis.
authors: Boston Medical Center, Boston, MA 02118, USA. sigurdisha@gmail.com
authors: Sigurdis
authors: S
authors: Haraldsdottir
authors: Thorarinn
authors: T
authors: Gudnason
authors: Axel F
authors: AF
authors: Sigurdsson
authors: Jonina
authors: J
authors: Gudjonsdottir
authors: Sam J
authors: SJ
authors: Lehman
authors: Kristjan
authors: K
authors: Eyjolfsson
authors: Sigurpall S
authors: SS
authors: Scheving
authors: C Michael
authors: CM
authors: Gibson
authors: Udo
authors: U
authors: Hoffmann
authors: Birna
authors: B
authors: Jonsdottir
authors: Karl
authors: K
authors: Andersen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000601:surgery*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*