[The role of estrogens in angiogenesis in the female reproductive system].
Under physiological conditions, angiogenesis is routinely observed in the uterus. Multiple lines of evidence suggest that estrogen directly modulates angiogenesis via effects on endothelial cells. A clear association between estrogen, estrogen receptor expression by endothelial cells and angiogenic activity has been confirmed. This minireview will discuss the recent progress in research into the role of estrogens in angiogenesis.
Dobrzycka
Bozena
B
Zakład Pielegniartwa Połosniczo-Ginekkologicznego Uniwersytetu Medycznego, Białystok. bdobrzycka@gmail.com
Kinalski
Maciej
M
Piechocka
Dorota
D
Terlikowski
Sławomir J
SJ
D000328:Adult; D042783:Endothelial Cells / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D014599:Uterus / Q000098:blood supply*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D004967:Estrogens; D042461:Vascular Endothelial Growth Factor A; D019001:Nitric Oxide Synthase