title: Aphasic and visual aura with increased vasogenic leakage: an atypical migrainosus status.
abstract: The pathogenesis of migraine with aura has not been fully established yet. The release of vasoactive substances and intracranial extracerebral blood vessel vasodilatation are probably related to stimulation of meningeal blood vessels through trigeminal afferents. Here, we report a 67 year old woman developing migraine with aphasia and right hemianopsia, lasting 4 days in duration. After spontaneous recovery, she experienced the same symptoms without migraine lasting for 15 h. MRI, performed during this last episode, revealed increased perfusion and leakage of contrast into subarachnoid space. In migraine with prolonged aura hyperperfusion with vasogenic edema might explain cortical function impairment and contribute to neurological deficits.
authors: Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy.
authors: Silvia
authors: S
authors: Lanfranconi
authors: Stefania
authors: S
authors: Corti
authors: Anna
authors: A
authors: Bersano
authors: Antonella
authors: A
authors: Costa
authors: Alessandro
authors: A
authors: Prelle
authors: Monica
authors: M
authors: Sciacco
authors: Nereo
authors: N
authors: Bresolin
authors: Isabella
authors: I
authors: Ghione
mesh_terms: D000368:Aged; D001037:Aphasia / Q000188:drug therapy / Q000473:pathology*; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D005444:Flunarizine / Q000627:therapeutic use; D005500:Follow-Up Studies; D007839:Functional Laterality; D006423:Hemianopsia / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D020325:Migraine with Aura / Q000188:drug therapy / Q000473:pathology*; D013346:Subarachnoid Space / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D003287:Contrast Media; D014665:Vasodilator Agents; D005444:Flunarizine