[Expression of annexin II in patients with hematologic malignancies].
This study was purposed to investigate the expression of annexin II in patients with hematologic malignancies and its role in genesis and development of hematologic malignancies. The expression levels of annexin II in bone marrow cells from untreated 81 patients with acute leukemia, 6 patients with MM and 20 patients with iron deficiency anemia were detected by real-time PCR assay. The results showed that the expression of annexin II mRNA significantly increased in M(3) patients as compared with others, the expression of annexin II gene in groups M(5), MM, M(4) were higher than that of other groups except M(3) group, and there were no significant difference in expression of annexin II gene between M(1) + M(2) groups and controls. It is concluded that the expression of annexin II gene significantly increased in patients M(5), M(4), MM, who showed higher ratio of infiltration than other patients. It is inferred that the annexin II participates in invasion and infiltration of hematologic malignancies probably through enhancing the degradation of extracellular matrix by cells of hematologic malignancies.
Zhang
Li-Yi
LY
The First Hospital, Suzhou University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou, Jiangsu Province, China.
Jiang
Miao
M
Li
Xia
X
Shen
Fei
F
Jia
Ruan
R
Ruan
Chang-Geng
CG
D000293:Adolescent; D000328:Adult; D017306:Annexin A2 / Q000235:genetics*; D001854:Bone Marrow Cells / Q000378:metabolism; D005260:Female; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
C472822:ANXA2 protein, human; D017306:Annexin A2