Remote ischemic conditioning: evolution of the concept, mechanisms, and clinical application.
Remote ischemic conditioning is a novel concept of protection against ischemia-reperfusion injury. Brief controlled episodes of intermittent ischemia of the arm or leg may confer a powerful systemic protection against prolonged ischemia in a distant organ. This conditioning phenomenon is clinically applicable and can be performed before--preconditioning, during--perconditioning, or after--postconditioning prolonged distant organ ischemia. The remote ischemic conditioning may have an immense impact on clinical practice in the near future.
Saxena
Pankaj
P
Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, University of Western Australia, Perth, Australia.
Newman
Mark A J
MA
Shehatha
Jaffar S
JS
Redington
Andrew N
AN
Konstantinov
Igor E
IE
D003326:Coronary Circulation; D006439:Hemodynamics; D006801:Humans; D007511:Ischemia; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D015398:Signal Transduction; D013997:Time Factors