title: [In vitro inhibitory mechanism of respiratory syncytial virus with solution prescription of zhidanhuayu].
abstract: OBJECTIVE
  To study the effective part of solution prescription of Zhidanhuayu (ZDHY) against respiratory syncytial virus (RSV) in vitro.
  
  
  METHODS
  Observe the pathology of RSV to Hep-2 under the condition of different concentrations and each effective part of ZDHY.
  
  
  RESULTS
  The concentration limit causing celluar toxicity of ZDHY is 5.5 mg/ml. The ZDHY failed to block the absorption of RSV to Hep-2 within this concentration, and consequently the cell fell into the full pathological changes. During the concentration of 2.75-5.50 mg/ml, the ZDHY directly destroyed virus array,meanwhile, the infected cells that treated by the medicine kept healthy also.
  
  
  CONCLUSIONS
  ZDHY could not defend the infection of RSV, but is able to destroy the RSV directly and inhibit the RSV inhabiting in the cell.
authors: Department of Pediatrics, Beijing Friendship Hospital Affiliate of Capital University of Medical Sciences, Beijing 100050, China.
authors: Yu-hua
authors: YH
authors: Liu
authors: An-cun
authors: AC
authors: Hou
authors: Gao-chao
authors: GC
authors: Zhao
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002460:Cell Line; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000627:therapeutic use; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000502:physiology; D014709:Vero Cells / Q000187:drug effects / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal