title: DNA deaminases: AIDing hormones in immunity and cancer.
abstract: It is well established that hormones can cause cancer, much less known is how they induce this change in our somatic cells. This review highlights the recent finding that estrogen can exert its DNA-damaging potential by directly activating DNA deaminases. This recently discovered class of proteins deaminate cytosine to uracil in DNA, and are essential enzymes in the immune system. The enhanced production of a given DNA deaminase, induced by estrogen, can lead not only to a more active immune response, but also to an increase in mutations and oncogenic translocations. Identifying the direct molecular link between estrogen and a mutation event provides us with new targets for studying and possibly inhibiting the pathological side-effects of estrogen.
authors: DNA Editing Laboratory, Clare Hall Laboratories, London Research Institute, South Mimms, EN6 3LD, UK. skpm@cancer.org.uk
authors: Svend K
authors: SK
authors: Petersen-Mahrt
authors: Heather A
authors: HA
authors: Coker
authors: Siim
authors: S
authors: Pauklin
mesh_terms: D004967:Estrogens / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology / Q000209:etiology*; D009709:Nucleotide Deaminases / Q000502:physiology*
chemical_list: D004967:Estrogens; D009709:Nucleotide Deaminases