Diterpenoids from the Mediterranean brown alga Dictyota sp. evaluated as antifouling substances against a marine bacterial biofilm.
Four new cyclized diterpenes, one xenicane (1) and three dolabellanes (2-4), were isolated, along with seven previously reported metabolites [3beta-hydroxydilophol (5), dictyols E (6) and C (7), hydroxycrenulide (8), 9-acetoxy-15-hydroxy-1,6-dollabelladiene (9), hydroxyacetyldictyolal (10), and fucoxanthin], from a Mediterranean species of Dictyota sp. collected in Le Brusc Lagoon (French Mediterranean coast). Their structures, as well as their relative configurations, were determined through extensive spectrometric (IR, HRESIMS, 1D and 2D NMR) data analysis and molecular modeling studies and by comparison with those reported in literature. Some of the isolated metabolites were evaluated for their antiadhesion activity against a marine bacterial biofilm (Pseudoalteromonas sp. D41).
Viano
Yannick
Y
Universite du Sud Toulon-Var, Avenue de l'Universite, BP 20132, F-83957 La Garde Cedex, France.
Bonhomme
Dominique
D
Camps
Mercedes
M
Briand
Jean-François
JF
Ortalo-Magné
Annick
A
Blache
Yves
Y
Piovetti
Louis
L
Culioli
Gérald
G
D018441:Biofilms / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000459:Phaeophyceae / Q000737:chemistry*; D031161:Pseudoalteromonas / Q000187:drug effects*; D013237:Stereoisomerism
D004224:Diterpenes