The molecular dating game: an antibody heavy chain hangs loose with a chaperone while waiting for its life partner.
In a recent issue of Molecular Cell, Feige et al. (2009) utilize the murine immunoglobulin system to shed light on a long-standing puzzle: how do cells coordinate folding of different polypeptides that ultimately form a complex?
Hebert
Daniel N
DN
Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Amherst, MA 01003, USA.
Gierasch
Lila M
LM
D000818:Animals; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins / Q000378:metabolism / Q000502:physiology*; D007147:Immunoglobulin Light Chains / Q000737:chemistry / Q000378:metabolism*; D007142:Immunoglobulin gamma-Chains / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D008958:Models, Molecular; D017510:Protein Folding; D020836:Protein Structure, Quaternary
D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins; D007147:Immunoglobulin Light Chains; D007142:Immunoglobulin gamma-Chains