A genome-wide scan for the Sasang constitution in a Korean family suggests significant linkage at chromosomes 8q11.22-23 and 11q22.1-3.
OBJECTIVE
We aim to identify the genetic loci responsible for Sasang constitution type, which is important for effective personalized treatments in traditional Korean medicine.


METHODS
Forty (40) individuals in a Korean family were recruited for linkage analysis and 310 unrelated individuals for association analysis to confirm the linkage result.


METHODS
Genome-wide linkage analysis was performed for the Korean family using the Affymetrix 500K arrays. MERLIN software was used for multipoint nonparametric linkage (NPL) analysis. The significant candidate regions in linkage analysis were also investigated with association analysis of independent 310 individuals.


RESULTS
Linkage analysis showed four significant peaks, 3q27.3, 8p11.21, 8q11.22-23, and 11q22.1-3, whose NPL Z scores are greater than 5.0. Among the significant loci, the 8q11.22-23 and 11q22.1-3 regions were supported by independent association analysis at the level of p < 0.05.


CONCLUSIONS
The 8q11.22-23 and 11q22.1-3 regions were suggested as the candidate region for significant linkage to Sasang constitution.
Won
Hong-Hee
HH
Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, South Korea.
Lee
Siwoo
S
Jang
Eunsu
E
Kim
Ka-Kyung
KK
Park
Young-Kyu
YK
Kim
Young Joo
YJ
Kim
Yong Sung
YS
Kim
Bu-Yeo
BY
Kim
Jong-Yeol
JY
Kim
Jong-Won
JW
D044466:Asian People / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D007723:Korea; D008297:Male; D055670:Medicine, Korean Traditional; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D013694:Temperament