title: Gait dynamics in Parkinson's disease: common and distinct behavior among stride length, gait variability, and fractal-like scaling.
abstract: Parkinson's disease (PD) is a common, debilitating neurodegenerative disease. Gait disturbances are a frequent cause of disability and impairment for patients with PD. This article provides a brief introduction to PD and describes the gait changes typically seen in patients with this disease. A major focus of this report is an update on the study of the fractal properties of gait in PD, the relationship between this feature of gait and stride length and gait variability, and the effects of different experimental conditions on these three gait properties. Implications of these findings are also briefly described. This update highlights the idea that while stride length, gait variability, and fractal scaling of gait are all impaired in PD, distinct mechanisms likely contribute to and are responsible for the regulation of these disparate gait properties.
authors: Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel-Aviv 64239, Israel. jhausdor@bidmc.harvard.edu
authors: Jeffrey M
authors: JM
authors: Hausdorff
mesh_terms: D000161:Acoustic Stimulation; D001696:Biomechanical Phenomena; D055592:Biophysical Phenomena; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D017709:Fractals; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008774:Methylphenidate / Q000627:therapeutic use; D008954:Models, Biological; D017711:Nonlinear Dynamics; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D016138:Walking / Q000502:physiology
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate