title: Primary sebaceous carcinoma of the corneaoscleral limbus with pagetoid recurrence.
abstract: We report a sebaceous carcinoma confined to the corneoscleral limbus without involvement of the eyelid. A 60-year-old man, who showed multiple masses on the corneaoscleral limbus and limbal ulceration but with normal eyelids, underwent surgical en-bloc excision of the masses. Histopathologic examination revealed a sebaceous carcinoma. Three weeks after excision, multiple pagetoid recurrences were found along the bulbar conjunctiva 2 mm away from the limbus. After the application of topical mitomycin C, the pagetoid spread regressed completely. After a 2 year follow-up, no other local or systemic recurrences were observed. This report shows that the ulcerative mass which is confined to only the corneoscleral limbus may be a sebaceous carcinoma even without eyelid involvement. Topical mitomycin C may be effective for treating pagetoid spread of sebaceous carcinoma of limbal origin.
authors: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors: Sang Jun
authors: SJ
authors: Park
authors: Won Ryang
authors: WR
authors: Wee
authors: Jin Hak
authors: JH
authors: Lee
authors: Mee Kum
authors: MK
authors: Kim
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000473:pathology* / Q000601:surgery; D001684:Biological Dressings; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D016850:Limbus Corneae / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D013508:Ophthalmologic Surgical Procedures / Q000379:methods; D012626:Sebaceous Gland Neoplasms / Q000473:pathology* / Q000601:surgery