[The determination of medical reference values for tumor markers in cerebrospinal fluid].
OBJECTIVE
To determine medical reference values for tumor markers in cerebrospinal fluid.


METHODS
Concentrations of CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, AFP, NSE, SCC and HCG were determined by means of double-antibody sandwich ELISA in 110 patients excluding primary tumors and meningeal carcinomatosis using Roche E170 modular immunoassay analyzer.


RESULTS
The determined medical reference values for tumor biomarkers in cerebrospinal fluid were as follows: CEA<0.573 microg/L, CA125<2.591 U/ml, CA15-3<2.045 U/ml, CA19-9<2.272 U/ml, CA72-4<1.252 U/ml, CYFRA21-1<1.44 ng/ml, AFP<0.968 microg/L, NSE<57.666 ng/ml, SCC<0.5 microg/L, HCG<0.769 U/L. There was no correlation between any tumor marker and age (P>0.05). Concentrations of tumor markers were not affected by gender (P>0.05).


CONCLUSIONS
Medical reference values for CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, AFP, NSE, SCC and HCG in cerebrospinal fluid were first determined.
Shi
Qiang
Q
Department of Neurology, General Hospital of PLA, Beijing 100853, China.
Pu
Chuan-qiang
CQ
Wu
Wei-ping
WP
Huang
Xu-sheng
XS
Yu
Sheng-yuan
SY
Tian
Cheng-lin
CL
Cao
Xiu-tang
XT
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid* / Q000592:standards*; D018394:CA-125 Antigen / Q000134:cerebrospinal fluid; D018395:CA-19-9 Antigen / Q000134:cerebrospinal fluid; D002272:Carcinoembryonic Antigen / Q000134:cerebrospinal fluid; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D055815:Young Adult
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen