Association of ApoE genotype with clinical features and outcome in idiopathic normal pressure hydrocephalus (iNPH): a preliminary report.
Fifteen patients suspected of having iNPH were clinically evaluated and their ApoE genotype determined prior to a possible ventriculoperitoneal shunt insertion. All patients fulfilling our criteria for intervention and who had a shunt implanted with good results were homozygous for the ApoE3/3 genotype.
Gudmundsson
Gardar
G
Landspitali University Hospital, Reykjavik, Iceland. gardar@mac.com
Kristjansdottir
Gudlaug
G
Cook
Elizabeth
E
Olafsson
Isleifur
I
D000368:Aged; D000369:Aged, 80 and over; D053318:Apolipoprotein E3 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D002557:Cerebrospinal Fluid Shunts; D004252:DNA Mutational Analysis; D003704:Dementia / Q000209:etiology / Q000503:physiopathology; D005260:Female; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000503:physiopathology; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006720:Homozygote; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000235:genetics* / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000209:etiology / Q000503:physiopathology
D053318:Apolipoprotein E3; D001057:Apolipoproteins E; D005819:Genetic Markers