title: [Preparation and characterization of curcumin loaded gelatin microspheres for lung targeting].
abstract: OBJECTIVE
  To study the preparation technology and physicochemical characterization of curcumin loaded gelatin microspheres for lung targeting.
  
  
  METHODS
  Curcumin loaded gelatin microspheres for lung targeting were prepared by the emulsion crosslinking method, and the preparation technology was optimized by orthogonal experimental design with biodegradable gelatin as the carrier, liquid paraffin as the oil phase, span 80 as the emulsifier.
  
  
  RESULTS
  The optimal curcumin loaded gelatin microspheres were global with smooth surface, 6.15% for the drug loading, 75.5% for the encapsulation efficiency. 86.6% of microspheres size was in the range of 5-30 microm. The release test in vitro showed that 50% of curcumin could release from gelatin microspheres in 22 h and 77% in 48 h.
  
  
  CONCLUSIONS
  The preparation technology is good and stable, and the obtained microspheres can control the release of curcumin.
authors: Institution of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China. caofl1898@yahoo.com.cn
authors: Feng-Liang
authors: FL
authors: Cao
authors: Yan-Wei
authors: YW
authors: Xi
authors: Lin
authors: L
authors: Tang
authors: Ai-Hua
authors: AH
authors: Yu
authors: Guang-Xi
authors: GX
authors: Zhai
mesh_terms: D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D004355:Drug Stability; D005780:Gelatin / Q000737:chemistry*; D008168:Lung / Q000378:metabolism; D008863:Microspheres; D010316:Particle Size; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D005780:Gelatin; D003474:Curcumin