title: Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma.
abstract: BACKGROUND
  Tumor lysis syndrome (TLS) is rare in the treatment of solid tumors, but it may occur in myelolymphoproliferative diseases.
  
  
  METHODS
  A 58-year-old man with bulky metastatic melanoma of the liver was treated with transcatheter arterial infusion of cisplatin and embolization therapy. The patient developed classic signs of TLS within 24 h of chemotherapy, including acute renal failure.
  
  
  RESULTS
  The patient was treated with aggressive hydration, allopurinol, and repeated hemodialysis. He gradually improved and his biochemical markers returned to normal.
  
  
  CONCLUSIONS
  TLS is an uncommon, but potentially life-threatening, complication in melanoma and other solid tumors. It is important for oncologists to recognize this complication and prevent its development if bulky metastatic disease and several pre-existing risk factors, such as multiple and bulky liver metastases, elevated lactate dehydrogenase, and hyperuricemia, are present.
authors: Department of Dermatology, University of Tsukuba, Japan.
authors: Yoshiyuki
authors: Y
authors: Nakamura
authors: Yasuhiro
authors: Y
authors: Nakamura
authors: Enmi
authors: E
authors: Hori
authors: Junichi
authors: J
authors: Furuta
authors: Yoshiyuki
authors: Y
authors: Ishii
authors: Takenori
authors: T
authors: Takahashi
authors: Yasuhiro
authors: Y
authors: Kawachi
authors: Fujio
authors: F
authors: Otsuka
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology; D015275:Tumor Lysis Syndrome / Q000209:etiology* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin