title: [Fibrate-induced deterioration of renal function].
abstract: BACKGROUND
  Fibrates represent one of the medications used to treat patients with hyperlipemia. Deterioration in renal function is not a very known adverse effect of fibric acid derivates. In the last 26 months we have detected thirteen patients with acute renal failure associated to fibrates in our outpatients' clinic.
  
  
  METHODS
  The aim of our study is to analyze our experience in deterioration in renal function associated to fibrates use. This is a retrospective charts review.
  
  
  RESULTS
  From the thirteen patients (8 males/5 females) with mean age of 65.5 +/- 12.2 years, ten received Fenofibrate (FN), one Bezafibrate (BZ) and two Gemfibrozil (GF). Six cases had previously normal renal function and the seven remaining had mild chronic renal failure (CRF). The increase of serum Creatinine (Crs) value was higher than 74%. Acute renal failure was reversible in 9 patients (group 1), but the other 4 did not recover their previous renal function (group 2). The average of Crs before fibrate treatment was 1.33 +/- 0.36 mg/dl (Creatinine clearance 63.2 +/- 26.6 ml/min) and the highest average of Crs during the treatment was 2.22 +/- 0.49 mg/d (Creatinine clearance 37.3 +/- 11.9 ml/min). The average time until acute renal failure diagnosis was 6.7 +/- 5.8 months and the recovery of renal function was delayed an average of 3.8 +/- 3.5 months after fibrates withdrawn. Group 2 patients had a higuer Crs and longer time with fibrates than group 1 patients. CPK values were normal in all cases. In two patients renal biopsy was performed and no significant lesions were detected.
  
  
  CONCLUSIONS
  The fibrate treatment can induce an acute renal failure. Four patients (30.8%) did not recover their basal renal function. When fibrate treatment begins a renal function should be monitored specially in patients with CRF.
authors: Department of Nephrology. 12 de Octubre University Hospital. Madrid, Spain. nipolanco@yahoo.es
authors: N
authors: N
authors: Polanco
authors: E
authors: E
authors: Hernández
authors: E
authors: E
authors: González
authors: E
authors: E
authors: Gutiérrez Martínez
authors: I
authors: I
authors: Bello
authors: V
authors: V
authors: Gutiérrez-Millet
authors: F
authors: F
authors: García
authors: E
authors: E
authors: Morales
authors: M
authors: M
authors: Praga
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002995:Clofibric Acid / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000960:Hypolipidemic Agents; D002995:Clofibric Acid