ACP1 genotype, glutathione reductase activity, and riboflavin uptake affect cardiovascular risk in the obese.
Erythrocyte acid phosphatase (ACP locus 1), also known as low-molecular-weight protein tyrosine phosphatase, has previously been associated to glycemia, dyslipidemia, and obesity. In this study, ACP1 genotype and activity were tested in 318 women aged 19 to 83 (mean, 51.74 +/- 13.44) years. ACP1 genotype was found to directly correlate to glutathione reductase activity (P < .001) and levels of low-density lipoprotein cholesterol (P = .038). Glutathione reductase activity was in turn found to correlate to a series of cardiovascular risk factors such as systolic arterial pressure (P < .001), total cholesterol levels (P = .018), and low-density lipoprotein cholesterol levels (P = .039). A possible protective effect of ACP1 genotype AA against these cardiovascular risk factors was observed in this study. Furthermore, this work hypothesizes that nutritional riboflavin uptake becomes more crucial as body mass index increases, to counteract oxidative stress and minimize cardiovascular risk. This might be especially true in ACP1 genotypes AC, BC, and CC, which might possibly show the least endogenous protection against oxidative stress.
Apelt
Nadja
N
Laboratório de Genética e Centro de Metabolismo e Endocrinologia, FML, Genetic Laboratory and Centre for Metabolism and Endocrinology, Medical Faculty, Lisbon University, Portugal. ink_2010@hotmail.com
da Silva
Alda Pereira
AP
Ferreira
Joana
J
Alho
Irina
I
Monteiro
Cristina
C
Marinho
Cláudia
C
Teixeira
Pedro
P
Sardinha
Luís
L
Laires
Ma José
MJ
Mascarenhas
Mário Rui
MR
Bicho
Manuel Pires
MP
D000135:Acid Phosphatase / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005838:Genotype; D005980:Glutathione Reductase / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012256:Riboflavin / Q000378:metabolism*; D018570:Risk Assessment; D055815:Young Adult
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D011518:Proto-Oncogene Proteins; D005980:Glutathione Reductase; D000135:Acid Phosphatase; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases; D012256:Riboflavin