title: Imidazole-containing (N3S)-Ni(II) complexes relating to nickel containing biomolecules.
abstract: Dimeric (N(2)S)Ni complexes and the monomeric N(2)S(2) bismercaptodiazacycloheptane nickel complex, (bme-dach)Ni, serve as precursors to two N(2)-, N'-/ S- complexes where N(2) = diazacycloheptane, N' = imidazole and S = thiolate. As rare examples of nickel complexes containing a mixed thiolate/imidazole ligand set, these complexes are characterized by X-ray diffraction, UV/vis, and variable temperature (1)H NMR spectroscopies, and electrochemistry. Density functional theory computations relate the orientation of the imidazole with respect to the N(2)N'SNi square plane to the VT NMR observed fluxionality and activation parameters. The superoxide dismutase activity of the imidazole complexes was investigated by the nitroblue tetrazolium assay.
authors: Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
authors: Roxanne M
authors: RM
authors: Jenkins
authors: Michael L
authors: ML
authors: Singleton
authors: Elky
authors: E
authors: Almaraz
authors: Joseph H
authors: JH
authors: Reibenspies
authors: Marcetta Y
authors: MY
authors: Darensbourg
mesh_terms: D007093:Imidazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D017672:Nitrogen Compounds / Q000737:chemistry* / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism*; D013379:Substrate Specificity; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013457:Sulfur Compounds / Q000737:chemistry* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D007093:Imidazoles; D017672:Nitrogen Compounds; D012097:Repressor Proteins; D013438:Sulfhydryl Compounds; D013457:Sulfur Compounds; C029899:imidazole; D009532:Nickel; D013482:Superoxide Dismutase