Nucleic acid-induced self-assembly of a platinum(II) terpyridyl complex: detection of G-quadruplex formation and nuclease activity.
A simple "proof-of-principle" concept for the monitoring of G-quadruplex formation and nuclease activity based on the unique self-assembly properties of a platinum(II) terpyridyl complex, has been demonstrated.
Yu
Cong
C
Centre for Carbon-Rich Molecular and Nanoscale Metal-Based Materials Research, Department of Chemistry and HKU-CAS Joint Laboratory on New Materials, The University of Hong Kong, Hong Kong, P. R. China.
Chan
Kenneth Hoi-Yiu
KH
Wong
Keith Man-Chung
KM
Yam
Vivian Wing-Wah
VW
D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism*; D054856:G-Quadruplexes; D009942:Organometallic Compounds / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D009942:Organometallic Compounds; D011725:Pyridines; D010984:Platinum; D004247:DNA; D003851:Deoxyribonucleases; C023666:pyridine