[Hormones and osteoporosis update. Glucocorticoids and bone].
Glucocorticoids are a class of vital steroid hormone which exhibit permissive effects on transactivation in a variety of cells, including those in bone. Glucocorticoid-induced osteoporosis, on the other hand, predisposes to fragility fracture by compromising bone strength and can be understood as a disease primarily characterized by a deficiency in bone quality. It is a major challenge in bone biology to understand these two contrasting sides of glucocorticoid activity in bone.
Ikeda
Kyoji
K
Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology.
D019386:Alendronate / Q000627:therapeutic use; D000818:Animals; D002118:Calcium / Q000378:metabolism; D050723:Fractures, Bone / Q000209:etiology; D005938:Glucocorticoids / Q000009:adverse effects* / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects / Q000502:physiology; D010024:Osteoporosis / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000627:therapeutic use; D011965:Receptors, Glucocorticoid / Q000502:physiology
D005938:Glucocorticoids; D010281:Parathyroid Hormone; D011965:Receptors, Glucocorticoid; D002118:Calcium; D006854:Hydrocortisone; D019386:Alendronate