Role of Nod2 in the development of Crohn's disease.
Crohn's Disease (CD) is caused by a loss of the regulatory capacity of the immune apparatus. Nod2 is an intracellular bacterial sensor and its mutations are associated with the development of CD. Here we summarize recent and controversial findings about the role of the Nod2 mutants in the disease process.
Yamamoto
Soichiro
S
Department of Microbiology and Immunology, Weill Medical College of Cornell University 1300 York Avenue, New York, NY 10021, USA.
Ma
Xiaojing
X
D003424:Crohn Disease / Q000276:immunology* / Q000473:pathology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008264:Macrophages / Q000276:immunology; D008954:Models, Biological; D009000:Monocytes / Q000276:immunology; D050505:Mutant Proteins / Q000235:genetics* / Q000276:immunology*; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics* / Q000276:immunology*
D016207:Cytokines; D050505:Mutant Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein