title: Primary large gastrointestinal stromal tumor of the liver: report of a case.
abstract: A 30-year-old man was diagnosed to have a large intra-abdominal tumor in 1999. A histological examination of a resected liver specimen from an operation in 2002 revealed a gastrointestinal stromal tumor (GIST), diagnosed based on positive immunostaining for CD34 and c-kit. Two years after the operation, new lesions developed in the residual liver and the lesser curvature of the stomach. An immunohistological examination of both specimens showed the features of a GIST, thus matching those of the first histological examination of the liver GIST. While there were no mutations at exon 11 of c-kit in the liver GISTs resected in 2002 and 2004, the gastric lesion had a mutation at P577L (CCT to CTT) at exon 11. Therefore, the liver GIST and the gastric lesion were diagnosed to be independent. The patient already has survived for more than 9 years after receiving surgery three times and with administration of imatinib.
authors: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-Kawaramachi, Kamigyo-ku, Kyoto, 602-8566, Japan.
authors: Toshiya
authors: T
authors: Ochiai
authors: Teruhisa
authors: T
authors: Sonoyama
authors: Shojiro
authors: S
authors: Kikuchi
authors: Hisashi
authors: H
authors: Ikoma
authors: Takeshi
authors: T
authors: Kubota
authors: Masayoshi
authors: M
authors: Nakanishi
authors: Daisuke
authors: D
authors: Ichikawa
authors: Shijiro
authors: S
authors: Kikuchi
authors: Hitoshi
authors: H
authors: Fujiwara
authors: Kazuma
authors: K
authors: Okamoto
authors: Chohei
authors: C
authors: Sakakura
authors: Yukihito
authors: Y
authors: Kokuba
authors: Hiroki
authors: H
authors: Taniguchi
authors: Eigo
authors: E
authors: Otsuji
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D046152:Gastrointestinal Stromal Tumors / Q000628:therapy*; D006498:Hepatectomy; D006801:Humans; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D012086:Reoperation; D012878:Skin Neoplasms / Q000628:therapy*; D013274:Stomach Neoplasms / Q000556:secondary / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate