title: Preemptive analgesic effects of intravenous paracetamol in total abdominal hysterectomy.
abstract: OBJECTIVE
  Paracetamol is primarily thought to be a cyclooxygenase inhibitor acting through the central nervous system. Indirect effects of paracetamol are through the serotoninergic system as a non-opioid analgesic. In this study, total abdominal hysterectomy patients were given intravenous (iv) paracetamol 1 g preoperatively or intraoperatively to assess its postoperative analgesic effects.
  
  
  METHODS
  90 patients undergoing total abdominal hysterectomy were enrolled into the study. Patients were randomized into three groups: in Group I, iv paracetamol 1 g was given 30 minutes prior to induction. In Group II, iv paracetamol 1 g was given prior to skin closure. Group III served as the control group and received saline as placebo. Postoperatively, all patients received morphine via patient-controlled analgesia pump. Postoperatively, rest and activity pain scores, sedation scores, hemodynamic parameters, postoperative morphine consumption, side effects, patient satisfaction, and total hospital stay were recorded.
  
  
  RESULTS
  In the control group, at rest and movement pain scores and total morphine consumption via patient-controlled analgesia were higher than in Groups I and II. When Groups I and II were compared, total morphine consumption was much greater in Group II. Intravenous paracetamol intraoperatively and postoperatively did not result in any hemodynamic effects.
  
  
  CONCLUSIONS
  In total abdominal hysterectomy, preemptive iv paracetamol 1 g provided good quality postoperative analgesia, with decreased consumption of morphine and minimal side effects.
authors: Department of Anesthesiology and Reanimation, Uludag University Faculty of Medicine, Bursa, Turkey.
authors: Semih
authors: S
authors: Arici
authors: Alp
authors: A
authors: Gurbet
authors: Gürkan
authors: G
authors: Türker
authors: Belgin
authors: B
authors: Yavaşcaoğlu
authors: Sükran
authors: S
authors: Sahin
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000627:therapeutic use; D016058:Analgesia, Patient-Controlled; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007262:Infusions, Intravenous; D007430:Intraoperative Care; D007902:Length of Stay; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D017060:Patient Satisfaction; D011182:Postoperative Care; D011300:Preoperative Care
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D009020:Morphine