title: Combining spatial and temporal information to explore function-guide action of acupuncture using fMRI.
abstract: OBJECTIVE
  To investigate the brain response patterns of modulation of GB37 (Guangming) and KI8 (Jiaoxin).
  
  
  METHODS
  An experiment using nonrepeated event-related fMRI design was carried out on 28 subjects with electroacupuncture stimulation (EAS) at GB37 or KI8 on the left leg. The discrete cosine transform and functional connectivity methods were adopted to detect the differences related with these two acupoints before and after the EAS.
  
  
  RESULTS
  Spatial patterns were distinct for EAS at the two acupoints, and the overlapping brain regions were mainly located in the posterior cingulate cortex (PCC) and precuneus (pC). Two opposite patterns of modulation in the default mode network were detected from the temporal patterns with the overlapping PCC/pC as the region of interest. Furthermore, the specific responses of sustained effects at these acupoints were also identified.
  
  
  CONCLUSIONS
  Spatial and temporal patterns of the sustained effect modulation of GB37 and KI8 were distinct. We suggest these findings may attribute to the functional specificity of a certain acupoint. Moreover, our current results reflect a significant methodological contribution to future acupuncture studies.
authors: School of Sino-Dutch Biomedical and Information Engineering, Northeastern University, Shenyang, Liaoning, China.
authors: Peng
authors: P
authors: Liu
authors: Wei
authors: W
authors: Qin
authors: Yi
authors: Y
authors: Zhang
authors: Jie
authors: J
authors: Tian
authors: Lijun
authors: L
authors: Bai
authors: Guangyu
authors: G
authors: Zhou
authors: Jixin
authors: J
authors: Liu
authors: Peng
authors: P
authors: Chen
authors: Jianping
authors: J
authors: Dai
authors: Karen M
authors: KM
authors: von Deneen
authors: Yijun
authors: Y
authors: Liu
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D015671:Electroacupuncture / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007866:Leg; D008279:Magnetic Resonance Imaging / Q000379:methods*; D055815:Young Adult