title: Cronkhite-Canada syndrome complicated with huge intramucosal gastric cancer.
abstract: Cronkhite-Canada syndrome (CCS) is a rare nonhereditary disorder with gastrointestinal polyposis and associated ectodermal changes. This report documents a 59-year-old Japanese man with CCS who underwent a total gastrectomy for gastric tumors. The resected specimen showed a huge gastric adenocarcinoma with numerous polyps throughout the stomach. The cancer was pathologically limited to within the mucosa and its histological structure resembled that of hyperplasia in CCS polyps, which led us to suppose that the carcinoma had arisen from hyperplastic CCS polyps. These results urged us to study the phenotypic expression of mucins, which revealed MUC2(-) and MUC5AC(+) and supported the diagnosis of the tumor as a gastric-type well-differentiate adenocarcinoma. A literature search revealed that 32 gastric carcinomas which developed in patients with CCS were mostly limited to within the submucosa in spite of their huge sizes, and such cancer development in CCS polyposis is therefore not considered to be unusual.
authors: Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.
authors: Hideaki
authors: H
authors: Karasawa
authors: Koh
authors: K
authors: Miura
authors: Kazuyuki
authors: K
authors: Ishida
authors: Tomohiko
authors: T
authors: Sase
authors: Terutada
authors: T
authors: Kobayashi
authors: Makoto
authors: M
authors: Kinouchi
authors: Mitsunori
authors: M
authors: Okabe
authors: Toshinori
authors: T
authors: Ando
authors: Naoyuki
authors: N
authors: Kaneko
authors: Akihiro
authors: A
authors: Yamamura
authors: Chikashi
authors: C
authors: Shibata
authors: Iwao
authors: I
authors: Sasaki
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005743:Gastrectomy; D015433:Glomerulonephritis, Membranous / Q000150:complications; D006801:Humans; D044483:Intestinal Polyposis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC / Q000096:biosynthesis; D055262:Mucin-2 / Q000096:biosynthesis; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery
chemical_list: C524625:MUC2 protein, human; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D055262:Mucin-2