title: Evaluation of MeningoFinder, a novel multiplex ligation-dependent probe amplification assay for simultaneous detection of six virus species causing central nervous system infections.
abstract: A multiplex ligation-dependent probe amplification assay for simultaneous detection of six virus species was developed and tested on clinical cerebrospinal fluid (CSF) samples. The assay, termed MeningoFinder, showed an accordance of 97%, concordance of 96%, interlaboratory sensitivity of 90%, and interlaboratory specificity of 94% compared to PCRs.
authors: Department of Medical Microbiology, Maastricht University Medical Center, The Netherlands. p.wolffs@mumc.nl
authors: P F G
authors: PF
authors: Wolffs
authors: C
authors: C
authors: Vink
authors: J
authors: J
authors: Keijdener
authors: B
authors: B
authors: Habek
authors: M
authors: M
authors: Reijans
authors: G
authors: G
authors: Simons
authors: C A
authors: CA
authors: Bruggeman
authors: A J C
authors: AJ
authors: van den Brule
mesh_terms: D001431:Bacteriological Techniques / Q000379:methods*; D002494:Central Nervous System Infections / Q000821:virology*; D002555:Cerebrospinal Fluid / Q000821:virology; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014777:Virus Diseases / Q000175:diagnosis*; D014780:Viruses / Q000235:genetics / Q000302:isolation & purification*