title: Overweight is associated with improved cancer-specific survival in patients with organ-confined renal cell carcinoma.
abstract: OBJECTIVE
  Overweight/obesity is known to increase the risk of developing renal cell carcinoma (RCC). However, data on the prognostic impact of overweight in RCC is still conflicting. We assessed whether different body mass index (BMI) levels at the time of surgery had an effect on the long-term prognosis of RCC patients.
  
  
  METHODS
  We evaluated 771 patients, with complete information about their BMI, who had undergone renal surgery for RCC between 1990 and 2005 at the authors' institution; the mean follow-up was 5.48 years.
  
  
  RESULTS
  Underweight, normal weight, pre-obesity, and obesity were diagnosed in 4 (0.5%), 239 (31%), 356 (46.2%), and 172 (22.3%) RCC patients, respectively. Overweight (BMI >25) was significantly associated with younger age (P = 0.004) and positive nodal status (P = 0.04) but not with tumor stage, grade, visceral metastasis, gender, histological subtype, or tumor-related symptoms. Overweight patients had a significantly lower risk of cancer-related death; their median 5-year tumor-specific survival rate was 80% as opposed to 72% for patients with a BMI below 25 (P = 0.003). Interestingly, subgroup analysis revealed that the positive association between overweight and survival was even more pronounced in organ-confined (P < 0.001) RCC, but no correlation was observed in advanced disease (P = 0.23).
  
  
  CONCLUSIONS
  We were able to identify overweight as an independent prognostic marker of improved tumor-specific survival in patients with organ-confined RCC. Basic research is required to resolve the dilemma of why, if a higher BMI predisposes to RCC, it concurrently prolongs survival after patients have undergone (partial) nephrectomy.
authors: Department of Urology, Philipps-University Medical School, Baldingerstrasse, 35043 Marburg, Germany. ajschrader@gmx.de
authors: Andres Jan
authors: AJ
authors: Schrader
authors: Julia
authors: J
authors: Rustemeier
authors: Jan Christoph
authors: JC
authors: Rustemeier
authors: Nina
authors: N
authors: Timmesfeld
authors: Zoltan
authors: Z
authors: Varga
authors: Axel
authors: A
authors: Hegele
authors: Peter Jochen
authors: PJ
authors: Olbert
authors: Rainer
authors: R
authors: Hofmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D050177:Overweight / Q000453:epidemiology; D011379:Prognosis; D016019:Survival Analysis