title: [Meta-analysis of antibiotic prophylaxis for postoperative bacteriuria in patients undergoing transrectal prostatic biopsy].
abstract: OBJECTIVE
  To investigate whether antibiotic prophylaxis can reduce the risk of postoperative bacteriuria in patients undergoing transrectal prostatic biopsy (TPB) who have sterile preoperative urine.
  
  
  METHODS
  MEDLINE, EMBASE, Cochrane Collaboration Reviews, CMCC, and CNKI were searched for randomized controlled trials (RCTs) comparing antibiotic prophylaxis with placebo/blank controls for patients undergoing TPB with preoperative sterile urine. The search strategy was made according to the Collaborative Review Group search strategy. Data were extracted by two reviewers using the designed extraction form. The software RevMan4.2 was used to review management and data analysis.
  
  
  RESULTS
  67 relevant RCTs were found, of which 12 qualified ones were included into the analysis. Antibiotic prophylaxis significantly decreased the rate of bacteriuria within the period 1 week after TPB (corresponding pooled relative risk (RR) and 95% CI was 0.32 (0.23 - 0.46, P < 0.01). The effective antibiotics included quinolones and quinolones combined with nitroimidazole, with the pooled RR and 95% CI of 0.31 (0.18 - 0.53, P < 0.01) and 0.32 (0.17 - 0.60, P = 0.0004) respectively. There was no significant difference in the effect between short treatment course protocol and long course protocol (P = 0.41).
  
  
  CONCLUSIONS
  Prophylactic antibiotics can significantly decrease the incidence of post-TPB bacteriuria. A significant decrease in bacteriuria incidence can be achieved with a range of antibiotic agents, including quinolones and-quinolones combined with nitroimidazole. Treatment protocols of any duration are effective.
authors: Department of Urology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors: Ming-gen
authors: MG
authors: Yang
authors: Xiao-kun
authors: XK
authors: Zhao
authors: Zhi-ping
authors: ZP
authors: Wu
authors: Ning
authors: N
authors: Xiao
authors: Chen
authors: C
authors: Lü
authors: Yi
authors: Y
authors: Hou
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001437:Bacteriuria / Q000517:prevention & control*; D001706:Biopsy / Q000009:adverse effects; D055499:Catheter-Related Infections / Q000517:prevention & control; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology; D016032:Randomized Controlled Trials as Topic; D012007:Rectum / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents