Myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with diffuse tubulointerstitial nephritis.
Renal involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is characterized by focal segmental crescentic and/or necrotizing glomerulonephritis. Here, we report the case of a 66-year-old woman showing myeloperoxidase (MPO)-ANCA positivity and mononeuritis multiplex whose kidney biopsy revealed severe and diffuse tubulointerstitial nephritis despite the fact that crescentic necrotizing glomerulonephritis was focal. The mechanism of tubulointerstitial injury in ANCA-associated vasculitis remains unclear. Further studies are necessary to confirm the relationship between diffuse tubulointerstitial nephritis and ANCA-associated vasculitis.
Son
Daisuke
D
Department of Nephrology and Endocrinology, University of Tokyo, Tokyo - Japan.
Kanda
Hiroko
H
Yamaguchi
Akihiro
A
Kawabata
Kimito
K
Kawakami
Takahisa
T
Kubo
Kanae
K
Higashihara
Mana
M
Shimizu
Jun
J
Uozaki
Hiroshi
H
Kuramochi
Shigeru
S
Misaki
Yoshikata
Y
Takeuchi
Fujio
F
Yamamoto
Kazuhiko
K
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D009395:Nephritis, Interstitial / Q000209:etiology / Q000473:pathology*; D009195:Peroxidase / Q000276:immunology*; D014657:Vasculitis / Q000209:etiology / Q000473:pathology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase