title: Caged O-phosphorothioyl amino acids as building blocks for Fmoc-based solid phase peptide synthesis.
abstract: The synthesis of 1-(2-nitrophenylethyl) caged O-phosphorothioylserine, -threonine and -tyrosine derivatives is reported. These amino acid building blocks can be directly incorporated into peptides by Fmoc-based solid phase synthesis as their pentafluorophenyl esters or as symmetric anhydrides. Upon irradiation with UV light, the thiophosphate group, representing a hydrolysis resistant phosphate analog, is revealed.
authors: Massachusetts Institute of Technology, Department of Chemistry, 18-590, 77 Massachusetts Ave., Cambridge, MA 02139, USA.
authors: Andreas
authors: A
authors: Aemissegger
authors: Christina N
authors: CN
authors: Carrigan
authors: Barbara
authors: B
authors: Imperiali