Acute lymphoblastic leukemia (ALL) with t(8;14)(q11.2;q32) in an elderly patient.
Acute lymphoblastic leukemia (ALL) with chromosome aberration t(8;14)(q11.2;q32) mostly affects patients younger than 20 years old. One third of patients with this translocation have been reported to have Down syndrome. This translocation has been reported rarely in patients over the age of 50. Here we report a 71-year-old male ALL patient who carried t(8;14)(q11.2;q32). Fluorescence in situ hybridization (FISH) analysis revealed the involvement of CCAAT enhancer-binding protein delta (CEBPD) gene on chromosome 8, and IgH gene on chromosome 14. This case provides a new aspect for considering this clinical entity.
Kubo
Yasutaka
Y
Kakazu
Naoki
N
Tasaka
Taizo
T
Oka
Daigo
D
Hirose
Tadashi
T
Matsuhashi
Yoshiko
Y
Wada
Hideho
H
Tohyama
Kaoru
K
Sugihara
Takashi
T
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D051743:CCAAT-Enhancer-Binding Protein-delta / Q000235:genetics; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D017809:Fatal Outcome; D050438:Genes, Immunoglobulin Heavy Chain; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic
C497252:CEBPD protein, human; D051743:CCAAT-Enhancer-Binding Protein-delta