In vitro effects of resveratrol on Trichinella spiralis.
Resveratrol, a natural phytoalexin found mainly in grapes, possesses antibacterial, antifungal, and antiviral properties. However, there is no information about its effects on helminths such as Trichinella sp. In the present study, we investigated the effects of resveratrol on the viability of Trichinella spiralis life stages in vitro. Adult forms, newborn larvae (NBL), and muscle larvae (ML) were incubated with resveratrol at concentrations varying from 12.5 to 200 microg/ml. Resveratrol showed significant anthelmintic activity against NBL and adult forms of Trichinella, but not against ML. Our results suggest that resveratrol may be useful as a therapeutic agent to treat trichinellosis in early stages and warrant its further assessment in animal models of disease.
Ozkoc
Soykan
S
Department of Parasitology, Dokuz Eylul University, Inciralti, Izmir 35340, Turkey. soykan.ozkoc@deu.edu.tr
Tuncay
Sema
S
Delibas
Songul Bayram
SB
Akisu
Ciler
C
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar / Q000469:parasitology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D016019:Survival Analysis; D017160:Trichinella spiralis / Q000187:drug effects*
D000871:Anthelmintics; D013267:Stilbenes; D000077185:Resveratrol