Neuromyelitis optica with HTLV-1 infection: different from acute progressive HAM?
Acute variant of human T lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) has been postulated as termed "acute HAM" or "rapidly progressive HAM". However, it remains controversial whether HAM itself could cause such rapid progression. We report a patient with HTLV-1 infection, in whom the diagnosis of neuromyelitis optica (NMO) could be made based on relapsing-remitting course of opticospinal disturbance and positive anti-aquaporin-4 (AQP4) antibody. Careful testing of anti-AQP4 antibody is necessary to establish whether or not acute HAM is a clinical variant of HAM.
Koga
Michiaki
M
Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube. kogamrk@yamaguchi-u.ac.jp
Takahashi
Toshiyuki
T
Kawai
Motoharu
M
Negoro
Kiyoshi
K
Kanda
Takashi
T
D051401:Aquaporin 4 / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D015490:HTLV-I Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D015493:Paraparesis, Tropical Spastic / Q000175:diagnosis* / Q000276:immunology; D013116:Spinal Cord / Q000473:pathology
C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies