title: Rare genotypes of protein Z gene are a risk factor for premature myocardial infarction but not protein Z plasma level.
abstract: Protein Z (PZ) is the cofactor of PZ dependent inhibitor (ZPI) that inhibits activated coagulation factor X. PZ was expected to play a role in coronary artery disease (CAD) but with inconsistent clinical findings. We therefore evaluated whether PZ plasma level and/or three genetic variants encoding for low PZ plasma level were associated with premature CAD in stable young post-myocardial infarction (MI) patients. PZ plasma level and three polymorphisms A-13G, G-103A and G79A were determined in 176 young stable post-MI patients and in 176 sex- and age-matched controls (FITE-NAT population). Moreover the genotypes, resulting from the combination of the three polymorphisms (A-13G/G-103A/G79A), were studied. PZ plasma level and the number of patients disclosing a PZ deficiency did not differ between post-MI patients and controls. The presence of the mutated allele for each polymorphism was associated with a significantly reduced level of PZ. The A-13G polymorphism was associated with premature CAD only in univariate analysis. Whereas, the presence of rare genotypes of PZ gene was an independent risk factor for premature CAD. In conclusion, PZ plasma level is not a key player in the pathophysiology of premature coronary artery disease. But, rare genotypes of PZ gene were found to be associated with premature CAD.
authors: Unit of Vascular Haemostasis, Rouen University Hospital, Rouen, France. Veronique.Le-Cam-Duchez@chu-rouen.fr
authors: Véronique
authors: V
authors: Le Cam-Duchez
authors: Claudine
authors: C
authors: Soria
authors: Claire Bal
authors: CB
authors: Dit Sollier
authors: Jeanne-Yvonne
authors: JY
authors: Borg
authors: Mathieu
authors: M
authors: Coudert
authors: Gilles
authors: G
authors: Montalescot
authors: Gaétan
authors: G
authors: Esposito
authors: Ludovic
authors: L
authors: Drouet
authors: Jean-Philippe
authors: JP
authors: Collet
mesh_terms: D000328:Adult; D017668:Age of Onset; D001798:Blood Proteins / Q000235:genetics* / Q000378:metabolism*; D015951:Factor Xa / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D001798:Blood Proteins; C026080:plasma protein Z; D015951:Factor Xa