title: [Relationship between polymorphisms of FCGR2B and susceptibility of children idiopathic thrombocytopenic purpura].
abstract: The aim of study was to investigate the relationship between polymorphisms of FCGR2B232 1/T oligonucleotide and the susceptibility of children with idiopathic thrombocytopenic purpura (ITP). DNA from 76 patients with ITP and 37 controls was extracted. The SNPs of FCGR2B-232 was detected by polymerase chain reaction (PCR) combined with direct sequencing. The genotype distribution and allele frequency among different groups were compared. The results showed that the genotype (I/I, I/T, T/T) of FCGR2B-232 were 55.3%, 42.1%, and 2.6% in 76 patients with ITP, while 81.1%, 18.9%, 0% in 37 controls. The allele frequencies of FCGR2B-232 in patients with ITP were 76.3% (I232) and 23.7% (T232), but 90.5% and 9.5% in controls. There were significant differences in genotype distributions between the ITP patients and controls (chi(2) = 7.45, = 0.024). The enrichment in Thr232 allele carrier was also significant among the ITP patients as compared with the controls (chi(2) = 7.18, p = 0.007, odds ratio 3.47). There were also significant differences in allele frequencies between the ITP patients and controls [chi(2) = 6.54, p = 0.011, odds ratio 2.97, 95% CI (1.25 - 7.05)]. It is concluded that the polymorphisms of FCGR2B-232 significantly correlates with the susceptibility of children suffering from ITP. The minor Thr232 allele may be a risk genetic factor to ITP children.
authors: Department of Hematology & Oncology, Guangzhou Children's Hospital, Guangzhou, Guangdong Province, China. linhly@126.com
authors: Li-Ya
authors: LY
authors: He
authors: Yu-Jun
authors: YJ
authors: Huang
authors: Dong-Bo
authors: DB
authors: Lai
authors: Ming-Bo
authors: MB
authors: Zhao
authors: Wen-Ying
authors: WY
authors: Zhang
authors: Tao
authors: T
authors: Xu
authors: Jia-Yi
authors: JY
authors: Wang
authors: Jun
authors: J
authors: Shi
authors: Yu-Hong
authors: YH
authors: Zhao
authors: Xiu-Xian
authors: XX
authors: Xu
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D011110:Polymorphism, Genetic; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*
chemical_list: C499173:FCGR2B protein, human; D017452:Receptors, IgG