title: Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives.
abstract: Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.
authors: Biotechnology Center in Southern Taiwan, Academia Sinica, 2F., No. 22, Lane 31, Sec. 1, Huandong Rd., Sinshih Township, Tainan County 744, Taiwan.
authors: Jiun-Ly
authors: JL
authors: Chir
authors: Pey-Jiuann
authors: PJ
authors: Wu
authors: Wei
authors: W
authors: Zou
authors: Milan
authors: M
authors: Bhasin
authors: Wei-Fu
authors: WF
authors: Juang
authors: Chao-Qi
authors: CQ
authors: Guo
authors: An-Tai
authors: AT
authors: Wu
mesh_terms: D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004987:Ethers / Q000737:chemistry*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D050111:Imino Sugars / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; D004987:Ethers; D050111:Imino Sugars; D006026:Glycoside Hydrolases