title: Two new steroidal saponins from Allium macrostemon bunge and their cytotoxity on different cancer cell lines.
abstract: Two new steroidal saponins (1 and 2) were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated by the spectral data as 26-O-beta-D-glucopyranosyl-5alpha-furost-25 (27)-ene-3beta, 12beta, 22, 26-tetraol-3-O-beta-D-glucopyranosyl (1-->2) [beta-D-glucopyranosyl (1-->3)]-beta-D-glucopyranosyl (1-->4)-beta-D-galactopyranoside (1) and 26-O-beta-D-glucopyranosyl-5beta-furost-20 (22)-25 (27)-dien-3beta, 12beta, 26-triol-3-O-beta-D-glucopyranosyl (1-->2)-beta-D-galactopyranoside (2), respectively. Their cytotoxic activities on several cancer cell lines (MCF-7, NCI-H460, SF-268 and HepG2) were tested. 1 showed special cytotoxity on SF-268, while 2 showed cytotoxity on NCI-H460 and SF-268 cell lines, respectively.
authors: Institute for Biomedical Research, Xiamen University, Xiamen 361005, China. haifeng@xmu.edu.cn
authors: Hai-Feng
authors: HF
authors: Chen
authors: Guang-Hui
authors: GH
authors: Wang
authors: Qiang
authors: Q
authors: Luo
authors: Nai-Li
authors: NL
authors: Wang
authors: Xin-Sheng
authors: XS
authors: Yao
mesh_terms: D000490:Allium / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins