The cartilage intermediate layer protein gene is associated with lumbar disc degeneration in collegiate judokas.
Lumbar disc degeneration is frequently seen in athletes. Lumbar disc diseases include a spectrum of diseases and/or symptoms, including lumbar disc degeneration. Some reports suggest an association between lumbar disc diseases and a functional single-nucleotide polymorphism (SNP;1184T/C, rs 2073711) of the cartilage intermediate layer protein ( CILP) gene. We hypothesized that lumbar disc degeneration occurrence may be significantly associated with SNP variants at the CILP gene in Japanese collegiate judo athletes. Eighty-nine Japanese judo athletes participated in this study. T2-weighted magnetic resonance imaging was used to define lumbar disc degeneration. Genotyping of the CILP gene (1184T/C) was performed using DNA sequencing. By using logistic regression analysis, significant associations of lumbar disc degeneration with the CILP C allele (odds ratio=4.1, 95% confidence interval: 1.57-10.71) and body weight (odds ratio=1.06, 95% confidence interval: 1.02-1.09) were observed. We conclude that the CILP gene 1184T/C polymorphism is a significant risk factor for lumbar disc degeneration occurrence in Japanese collegiate judo athletes.
Min
S K
SK
Nippon Sport Science University, Tokyo, Japan.
Nakazato
K
K
Okada
T
T
Ochi
E
E
Hiranuma
K
K
D000293:Adolescent; D000483:Alleles; D001835:Body Weight; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology*; D007564:Japan; D016015:Logistic Models; D008159:Lumbar Vertebrae / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D016139:Martial Arts; D020641:Polymorphism, Single Nucleotide; D011755:Pyrophosphatases / Q000235:genetics*; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D013122:Spinal Diseases / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D055815:Young Adult
D016326:Extracellular Matrix Proteins; C114607:CILP protein, human; D011755:Pyrophosphatases