Chronic eosinophilic leukemia with a unique translocation.
We report a case of chronic eosinophilic leukemia in a 9 year old girl who presented with anemia, thrombocytopenia, leucocytosis (mostly dysplastic eosinophils), lymphadenopathy and hepatosplenomegaly. There was no increase in blasts but myelofibrosis was seen in the bone marrow. A previously unreported translocation 46,XX,t(1;4)(q24;q35), was found on cytogenetic analysis and involvement of the myocardium was also present. Shortly after commencing steroids, the family abandoned therapy.
Arora
R S
RS
Department of Pediatrics, Moolchand Khairatiram Hospital, New Delhi, India. reemaraman@doctors.org.uk
D009202:Cardiomyopathies / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D002648:Child; D002908:Chronic Disease; D004452:Echocardiography; D004804:Eosinophils; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D014178:Translocation, Genetic
D005938:Glucocorticoids