title: Lack of association of angiotensin-converting enzyme insertion/deletion polymorphism and myocardial infarction at very young ages.
abstract: We examined whether angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism is associated with the development of myocardial infarction (MI) at < or = 35 years of age. The study sample consisted of 201 patients with premature MI and 140 age- and sex-matched healthy individuals. No difference was found in the distribution of ACE genotypes between the patients and controls. A higher prevalence of the DD genotype among hypertensives was found compared with the non-hypertensive patients (62.5% vs 35.6%, p = 0.01). ACE polymorphism is not associated with the development of premature MI and this might be due to the low prevalence of hypertension in young coronary patients.
authors: Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Greece.
authors: Loukianos S
authors: LS
authors: Rallidis
authors: Argyri
authors: A
authors: Gialeraki
authors: Christos
authors: C
authors: Varounis
authors: Nikolaos
authors: N
authors: Dagres
authors: Christos
authors: C
authors: Kotakos
authors: Anthi
authors: A
authors: Travlou
authors: John
authors: J
authors: Lekakis
authors: Dimitrios T
authors: DT
authors: Kremastinos
mesh_terms: D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017384:Sequence Deletion
chemical_list: D007703:Peptidyl-Dipeptidase A