Intraluminal fluorescence spectroscopy catheter with ultrasound guidance.
We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53+/-0.16 mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.
Stephens
Douglas N
DN
Park
Jesung
J
Sun
Yang
Y
Papaioannou
Thanassis
T
Marcu
Laura
L
D000818:Animals; D002404:Catheterization / Q000295:instrumentation / Q000379:methods*; D005263:Femoral Artery / Q000000981:diagnostic imaging*; D055100:Optical Fibers; D019047:Phantoms, Imaging; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods*; D013552:Swine; D018084:Ultrasonography, Interventional / Q000295:instrumentation / Q000379:methods*