title: Short stature in children with coeliac disease.
abstract: Coeliac disease (CD) is a genetically determined gluten-sensitive enteropathy resulting in nutrient malabsorption, with an increasing incidence world-wide. Clinical presentation in early childhood may include classic malabsorption symptoms, whereas older CD children often present extra-intestinal symptoms including short stature and pubertal delay. A gluten-free diet (GFD) generally leads to a rapid catch-up in growth and to normalization of the pituitary function. The pathogenesis of CD-associated short stature is still unclear. Besides the involvement of the growth hormone (GH)/insulin-like growth factor-I axis, a role for ghrelin was recently proposed. Furthermore, some CD patients do not show catch-up growth during GFD, despite reversion to seronegativity for CD markers including antiendomysial and anti-tissue transglutaminase antibodies. These subjects show GH deficiency and could potentially benefit from recombinant human GH therapy. This review deals with the management of short stature and the evaluation of growth axis function in CD children.
authors: Paediatric Department, University of Pavia, Fondazione IRCCS San Matteo, Italy.
authors: Cristina
authors: C
authors: Meazza
authors: Sara
authors: S
authors: Pagani
authors: Kamilia
authors: K
authors: Laarej
authors: Francesca
authors: F
authors: Cantoni
authors: Paola
authors: P
authors: Civallero
authors: Agata
authors: A
authors: Boncimino
authors: Mauro
authors: M
authors: Bozzola
mesh_terms: D001827:Body Height / Q000502:physiology; D002446:Celiac Disease / Q000150:complications* / Q000378:metabolism / Q000628:therapy*; D002648:Child; D002657:Child Development / Q000502:physiology; D006130:Growth Disorders / Q000209:etiology* / Q000628:therapy*; D019382:Human Growth Hormone / Q000172:deficiency / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I