title: Surgical resection of primary and metastatic hepatic malignancies following portal vein embolization.
abstract: BACKGROUND
  Portal vein embolization (PVE) has been used to induce hypertrophy in future liver remnants (FLRs) in preparation for major hepatic resection. We report our initial experience with PVE and identify potential predictors of unresectability following PVE.
  
  
  METHODS
  Patients with primary and metastatic hepatic malignancies (n = 20) who underwent PVE between 2004 and 2008 were categorized by surgical resection status and clinicopathologic factors were compared.
  
  
  RESULTS
  The cohort had the following histologies: colorectal adenocarcinoma (45%, n = 9), hepatocellular carcinoma (20%), cholangiocarcinoma (20%), and other (15%). Seven patients (35%) had previous liver-directed or regional therapy; 55% subsequently underwent successful liver resection, whereas 45% were deemed unresectable. Patients who underwent successful resection had tumor shrinkage after PVE compared to unresectable patients (% change in maximal tumor diameter, -6% vs. +45%, respectively; P = 0.027) and had a lower rate of baseline liver function test abnormality (0% vs. 56%, respectively; P = 0.004). Resected patients had an 83% 5-year overall survival.
  
  
  CONCLUSIONS
  Baseline liver dysfunction may predict subsequent unresectable hepatic disease following PVE and tumor progression after PVE appears to increase the likelihood for finding unresectable hepatic disease. Select patients should be considered for PVE with careful surveillance during the period of FLR hypertrophy.
authors: Division of Oncologic Surgery and Comprehensive Cancer Center, City of Hope, Duarte, California 91010, USA.
authors: Brian
authors: B
authors: Mailey
authors: Caitlyn
authors: C
authors: Truong
authors: Avo
authors: A
authors: Artinyan
authors: Joshua
authors: J
authors: Khalili
authors: Nicelio
authors: N
authors: Sanchez-Luege
authors: Jordan
authors: J
authors: Denitz
authors: Howard
authors: H
authors: Marx
authors: Lawrence D
authors: LD
authors: Wagman
authors: Joseph
authors: J
authors: Kim
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D001650:Bile Duct Neoplasms / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000601:surgery; D018281:Cholangiocarcinoma / Q000473:pathology; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000473:pathology; D004621:Embolization, Therapeutic; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D011300:Preoperative Care