Contributions to singing ability by the posterior portion of the superior temporal gyrus of the non-language-dominant hemisphere: first evidence from subdural cortical stimulation, Wada testing, and fMRI.
BACKGROUND
Although the substrates that mediate singing abilities in the human brain are not well understood, invasive brain mapping techniques used for clinical decision making such as intracranial electro-cortical testing and Wada testing offer a rare opportunity to examine music-related function in a select group of subjects, affording exceptional spatial and temporal specificity.


METHODS
We studied eight patients with medically refractory epilepsy undergoing indwelling subdural electrode seizure focus localization. All patients underwent Wada testing for language lateralization. Functional assessment of language and music tasks was done by electrode grid cortical stimulation. One patient was also tested non-invasively with functional magnetic resonance imaging (fMRI). Functional organization of singing ability compared to language ability was determined based on four regions-of-interest (ROIs): left and right inferior frontal gyrus (IFG), and left and right posterior superior temporal gyrus (pSTG).


RESULTS
In some subjects, electrical stimulation of dominant pSTG can interfere with speech and not singing, whereas stimulation of non-dominant pSTG area can interfere with singing and not speech. Stimulation of the dominant IFG tends to interfere with both musical and language expression, while non-dominant IFG stimulation was often observed to cause no interference with either task; and finally, that stimulation of areas adjacent to but not within non-dominant pSTG typically does not affect either ability. Functional fMRI mappings of one subject revealed similar music/language dissociation with respect to activation asymmetry within the ROIs.


CONCLUSIONS
Despite inherent limitations with respect to strictly research objectives, invasive clinical techniques offer a rare opportunity to probe musical and language cognitive processes of the brain in a select group of patients.
Suarez
Ralph O
RO
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. rosuarez@bwh.harvard.edu
Golby
Alexandra
A
Whalen
Stephen
S
Sato
Susumu
S
Theodore
William H
WH
Kufta
Conrad V
CV
Devinsky
Orrin
O
Balish
Marshall
M
Bromfield
Edward B
EB
D000328:Adult; D001307:Auditory Perception / Q000502:physiology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004827:Epilepsy; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007802:Language; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D009146:Music; D013060:Speech / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*; D014831:Voice / Q000502:physiology*; D055815:Young Adult