[Hormones and osteoporosis update. FGF23/Klotho and bone metabolism].
Fibroblast growth factor (FGF) 23 is a hormone which is produced by bone and lowers serum phosphate and 1,25-dihydroxyvitamin D levels by acting on kidney. FGF23 works through binding to Klotho-FGF receptor complex. Because excess and deficient actions of FGF23 result in metabolic bone diseases, FGF23/Klotho pathway is physiologically important for maintaining normal bone metabolism.
Fukumoto
Seiji
S
Division of Nephrology and Endocrinology, Department of Medicine, University of Tokyo Hospital.
D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000502:physiology*; D005966:Glucuronidase / Q000378:metabolism / Q000502:physiology; D006801:Humans; D000090265:Klotho Proteins; D010710:Phosphates / Q000097:blood; D011485:Protein Binding; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism / Q000502:physiology; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
C000717427:FGF23 protein, human; D010710:Phosphates; D017468:Receptors, Fibroblast Growth Factor; D014807:Vitamin D; D005346:Fibroblast Growth Factors; C097949:1,25-dihydroxyvitamin D; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins