No association between vitamin D receptor polymorphisms and coronary artery disease in a Chinese population.
The clinical features suggest that genetic factors may have a strong influence on susceptibility to coronary artery disease (CAD). The aim of this study was to investigate the association between FokI (rs2228570) and BsmI (rs1544410) of the vitamin D receptor (VDR) gene polymorphisms and patients with CAD in a Chinese population. One hundred and fifty-two CAD patients and 212 healthy controls were genotyped for the FokI and BsmI polymorphisms in VDR gene using polymerase chain reaction-restriction fragment length polymorphism. No significant differences were observed in the genotype and allele frequencies of the FokI and BsmI polymorphisms between the cases and controls (For FokI: odds ratio = 1.11, 95% confidence interval 0.83-1.50; for BsmI: odds ratio = 0.74, 95% confidence interval 0.44-1.23). There was no significant difference in the genotype distribution or the allele frequencies of VDR FokI and BsmI between two groups in a Chinese population.
Pan
Xin-Min
XM
Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University , Chengdu, Peoples' Republic of China .
Li
Dong-Ri
DR
Yang
Lan
L
Wang
En-Yin
EY
Chen
Tian-Yi
TY
Liu
Ya-Ju
YJ
Liu
Min
M
Liao
Zhi-Gang
ZG
D001483:Base Sequence; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*
D017931:DNA Primers; D018167:Receptors, Calcitriol