Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a non-ferrous smelter.
Serum Clara cell protein (CC16) and surfactant-associated protein D (SP-D) were measured in 161 workers exposed to sulphur dioxide (SO(2)) in a non-ferrous smelter. Seventy workers from a blanket manufacture served as referents. Exposure to SO(2) and tobacco smoking were associated with a decrease of CC16 and an increase of SP-D in serum. Tobacco smoking and exposure SO(2) interacted synergistically to decrease serum CC16 but not to increase serum SP-D. While further illustrating the potential of serum CC16 and SP-D, our study confirms that SO(2) can cause airways damage at exposure levels below current occupational exposure limits.
Haddam
Nahida
N
Laboratory of Medical Toxicology (ToxicoMed), Faculty of Medicine, University Abou Bekr Belkaid, Tlemcen, Algeria.
Samira
Sekkal
S
Dumont
Xavier
X
Taleb
Abdesselem
A
Haufroid
Vincent
V
Lison
Dominique
D
Bernard
Alfred
A
D000328:Adult; D015415:Biomarkers / Q000097:blood; D004391:Dust; D004848:Epithelium / Q000293:injuries / Q000378:metabolism; D006801:Humans; D019570:Inhalation Exposure; D055370:Lung Injury / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D016273:Occupational Exposure; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D012907:Smoking / Q000009:adverse effects; D013458:Sulfur Dioxide / Q000633:toxicity*; D014598:Uteroglobin / Q000097:blood*
D015415:Biomarkers; D004391:Dust; D037663:Pulmonary Surfactant-Associated Protein D; C556389:SCGB1A1 protein, human; D013458:Sulfur Dioxide; D014598:Uteroglobin