Protective effect of a Potentilla anserine polysaccharide on oxidative damages in mice.
Potentilla anserine polysaccharide (PAP) was studied in vivo to investigate its antioxidant activity using the model of dexamethasone-induced oxidative stress in mice. The investigation demonstrated that PAP at 50, 100 or 200mg/kg body weight for 7 days respectively increased thymus index and spleen index, glutathione level, superoxidase dismutase activity and total antioxidant capacity in both thymus and spleen and decreased the content of H(2)O(2) in spleen and NO in both thymus and spleen of mice. The results revealed that PAP was able to overcome dexamethasone-induced oxidative stress and might play an important role in repairs of oxidative damage in immunological system.
Hu
Ting-Jun
TJ
College of Animal Science and Technology, Guangxi University, 530005 Nanning, PR China. tingjunhu@126.com
Shuai
Xue-Hong
XH
Chen
Jiong-Ran
JR
Wei
Ying-Yi
YY
Zheng
Rong-Liang
RL
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D011134:Polysaccharides / Q000494:pharmacology*; D031987:Potentilla / Q000737:chemistry*; D020011:Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects / Q000201:enzymology
D000975:Antioxidants; D011134:Polysaccharides; D020011:Protective Agents; D009569:Nitric Oxide; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase; D005978:Glutathione