title: Trp64Arg polymorphism in ADRB3 gene is associated with elite endurance performance.
abstract: In this study, allele and genotype frequencies of the ADRB1 Arg389Gly (rs1801253), ADRB2 Gly16Arg (rs1042713) and Gln27Glu (rs1042714), and ADRB3 Trp64Arg (rs4994) variations were compared in the following three groups of Spanish (Caucasian) men: (1) world-class endurance athletes (E; runners and cyclists, n=100), (2) elite power athletes (P; sprinters, jumpers and throwers, n=53) and (3) non-athletic controls (C; n=100). No significant differences were observed in genotype and allele distributions among the study groups except for the ADRB3 Trp64Arg polymorphism in E versus C (27% vs 8% of carriers of the Arg allele in E and C, p<0.001; frequency of the minor Arg (C) allele of 14% vs 4% in E and C, p=0.001). Heterozygosity for the ADRB3 Trp64Arg polymorphism seems to be associated with elite endurance performance, while other variants of the β-adrenergic receptors' genes do not seem to significantly influence top-level sports performance, at least in athletes of Spanish origin.
authors: Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Madrid, Spain.
authors: Catalina
authors: C
authors: Santiago
authors: Jonatan R
authors: JR
authors: Ruiz
authors: Amaya
authors: A
authors: Buxens
authors: Marta
authors: M
authors: Artieda
authors: David
authors: D
authors: Arteta
authors: Marta
authors: M
authors: González-Freire
authors: Gabriel
authors: G
authors: Rodríguez-Romo
authors: Signe
authors: S
authors: Altmäe
authors: José I
authors: JI
authors: Lao
authors: Félix
authors: F
authors: Gómez-Gallego
authors: Alejandro
authors: A
authors: Lucia
mesh_terms: D000293:Adolescent; D000328:Adult; D054874:Athletic Performance / Q000502:physiology*; D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D055815:Young Adult
chemical_list: C568534:ADRB3 protein, human; D022702:Receptors, Adrenergic, beta-3