title: Anterior chamber depth and iridocorneal angle in healthy White subjects: effects of age, gender and refraction.
abstract: OBJECTIVE
  Prior to phakic intraocular lens implantation, it is important to obtain precise knowledge of the anterior chamber depth (ACD). Accurate topographic evaluation of the iridocorneal angle is helpful in estimating risk for angle-closure glaucoma. This study investigated the use of the Orbscan II system to measure ACD and the iridocorneal angle in healthy subjects and assessed the influences of age, gender and spherical equivalent on these parameters.
  
  
  METHODS
  The Orbscan II system was used to determine the ACD and iridocorneal angle in eight different positions in 390 healthy White subjects with a mean age of 41± 16years (range 10-80 years). The sample included 242 male and 148 female subjects. The influences of age, gender and spherical equivalent were assessed using multiple regression analysis.
  
  
  RESULTS
  Mean ACD was 2.87 ± 0.04 mm in male subjects and 2.81±0.37mm in female subjects. The explanatory variables relevant to the ACD were age (partial regression coefficient B = -0.0115, p < 0.0001), spherical equivalent (B = - 0.0562, p< 0.0001) and gender (B = 0.0996, p=0.0036). The mean iridocorneal angle (MIA) was 30.7 ± 2.0 ° in male and 31.6 ± 2.1° in female subjects. The variables relevant to the MIA were gender (B =- 0.865, p < 0.0001), age (B =- 0.017, p = 0.0007) and spherical equivalent (B = - 0.121, p = 0.001). The superior iridocorneal angle displayed the strongest negative correlation with age, whereas the temporal angle exhibited the least correlation with age.
  
  
  CONCLUSIONS
  The decline in ACD appears to be linear with age, amounting to a mean of 0.58 mm over 50 years. This may become clinically relevant in the use of phakic intraocular lenses. In addition, the angle is more severely constricted in the superior quadrant than in the temporal quadrant.
authors: Department of Ophthalmology, University of Schleswig-Holstein, Kiel, Germany. florian.ruefer@web.de
authors: Florian
authors: F
authors: Rüfer
authors: Anke
authors: A
authors: Schröder
authors: Alexa
authors: A
authors: Klettner
authors: Adjoa
authors: A
authors: Frimpong-Boateng
authors: Johann B
authors: JB
authors: Roider
authors: Carl
authors: C
authors: Erb
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000867:Anterior Chamber / Q000033:anatomy & histology*; D001699:Biometry; D002648:Child; D003315:Cornea / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007498:Iris / Q000033:anatomy & histology*; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D054120:Phakic Intraocular Lenses; D012029:Refraction, Ocular / Q000502:physiology*; D012737:Sex Factors; D044465:White People; D055815:Young Adult