title: [Study on the optimal extaction of total flavonoids from Tagetes erecta by central composite design-response surface methodology].
abstract: OBJECTIVE
  To optimize the process of extracting total flavonoids from Tagetes erecta.
  
  
  METHODS
  The influential factors were extraction temperature, ethanol concentration, reflux time and solvent volume fold. The evaluating indicator was the extraction rate of total flavonoids from Tagetes erecta. The central composite design-response surface methodology was used to optimize the process and the prediction was carried out.
  
  
  RESULTS
  The optimum conditions of extraction were 80% ethanol, 2.5 hours for reflux, 35 volume folds of solvent and 70 degrees C.
  
  
  CONCLUSIONS
  It shows that the optimum model is simple and highly predictive.
authors: Heilongjiang University of Chinese Medicine, Harbin 150040, China. jcp841006@yahoo.com.cn
authors: Chang-Ping
authors: CP
authors: Jia
authors: Bao-Cheng
authors: BC
authors: Tian
authors: Yan-Bing
authors: YB
authors: Li
authors: Ying-Bo
authors: YB
authors: Gao
authors: Bo-Meng
authors: BM
authors: Yu
authors: Wei-Ling
authors: WL
authors: Pan
mesh_terms: D000431:Ethanol / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D035264:Flowers / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D031686:Tagetes / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013997:Time Factors
chemical_list: D005419:Flavonoids; D012997:Solvents; D000431:Ethanol