title: Delivery of bioactive conjugated linoleic acid with self-assembled amylose-CLA complex.
abstract: A delivery system for bioactive conjugated linoleic acid (CLA) through a self-assembled amylose-CLA complex was investigated in comparison with a beta-cyclodextrin (BCD)-CLA complex. Successful complexation between CLA and amylose or BCD was confirmed by differential scanning calorimetry, X-ray diffraction, and Fourier transform infrared spectral analysis. The yield and complexing percentages were 71.9 and 1.4% for the amylose-CLA complex and 42.3 and 7.7% for the BCD-CLA complex, respectively. However, the amylose-CLA complex showed a better antioxidative protection effect on CLA than BCD-CLA complex, supporting a strong complexing interaction between CLA and amylose shown by thermogravimetric analysis. Compared to 15.9% of CLA released from the BCD-CLA complex under simulated small intestine conditions, 95.6% of CLA was released from the amylose-CLA complex. These results indicate that an amylose-lipid complex self-assembled in the natural way of food component interaction can be used to protect and deliver functional lipids or other bioactive components into the targeted small intestine for absorption.
authors: School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China.
authors: Ying
authors: Y
authors: Yang
authors: Zhengbiao
authors: Z
authors: Gu
authors: Genyi
authors: G
authors: Zhang
mesh_terms: D000688:Amylose / Q000737:chemistry*; D001682:Biological Availability; D016503:Drug Delivery Systems / Q000379:methods*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism; D044243:Linoleic Acids, Conjugated / Q000737:chemistry / Q000493:pharmacokinetics*; D008954:Models, Biological; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D044243:Linoleic Acids, Conjugated; D047392:beta-Cyclodextrins; D000688:Amylose