title: Association of moderate and severe hypertriglyceridemia with obesity, diabetes mellitus and vascular disease in the Spanish working population: results of the ICARIA study.
abstract: OBJECTIVE
  To study the prevalence, risk factors, and vascular disease associated with moderate and severe hypertriglyceridemia in an active working population.
  
  
  METHODS
  Cross-sectional study of 594,701 workers from all Spanish geographical areas, occupation sectors, ages, and sexes who underwent a yearly routine checkup. Data collected from participants included age, sex, anthropometric measurements, vascular risk factors, lipidic profile and basic biochemical analysis, from a fasting blood sample. A cardiovascular risk assessment was performed.
  
  
  RESULTS
  The study population included 428,334 males and 166,367 females, mean age 36+/-10 years. A total of 95,673 (16%) workers had mild hypertriglyceridemia (HTg) (Tg 150-399mg/dL), 7,081 (1.1%) had moderate HTg (400-999mg/dL), and 224 (0.03%) had severe HTg (>or=1000mg/dL). Of workers with hypertriglyceridemia, 90% were male. Age, obesity, type 1 and 2 diabetes, alcohol consumption, and vascular disease were associated with hypertriglyceridemia. Cardiovascular risk gradually increased for each HTg category. Amongst risk factors, the major independent predictor of mild-HTg was obesity (OR 2.42, CI 95% 2.37-2.48), whereas diabetes was a predictor of moderate HTg (OR 3.64, CI 95% 3.17-4.18) and severe HTg (OR 7.35, CI 95% 4.27-12.66). In multivariate analyses, HTg was gradually associated with vascular disease, even after adjusting for other risk factors.
  
  
  CONCLUSIONS
  In this working population, preventive programs for HTg and associated vascular disease should consider obesity-diabetes control as its first objective.
authors: Department of Internal Medicine, Hospital Virgen de la Victoria, Department of Medicine & Dermatology, University of Málaga, Málaga, Spain. valdivielso@uma.es
authors: Pedro
authors: P
authors: Valdivielso
authors: Miguel Angel
authors: MA
authors: Sánchez-Chaparro
authors: Eva
authors: E
authors: Calvo-Bonacho
authors: Martha
authors: M
authors: Cabrera-Sierra
authors: Juan Carlos
authors: JC
authors: Sainz-Gutiérrez
authors: Carlos
authors: C
authors: Fernández-Labandera
authors: Ana
authors: A
authors: Fernández-Meseguer
authors: Luis
authors: L
authors: Quevedo-Aguado
authors: Montserrat Ruiz
authors: MR
authors: Moraga
authors: Adolfo
authors: A
authors: Gálvez-Moraleda
authors: Arturo
authors: A
authors: González-Quintela
authors: Javier
authors: J
authors: Roman-Garcia
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000453:epidemiology* / Q000517:prevention & control; D004651:Employment; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D016272:Occupational Health; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology