The prevalence of colorectal neoplasia in patients with gastric cancer: a Korean Association for the Study of Intestinal Disease (KASID) Study.
OBJECTIVE
The goal of this study was to determine the prevalence of colorectal neoplasia, using colonoscopy surveillance, in a cohort of patients with gastric cancers.


BACKGROUND
The association between gastric cancer and colorectal cancer has been conflicting.


METHODS
A total of 543 patients (males, 362; females, 181) with gastric cancer were matched with 2 persons from the population without a diagnosis of gastric cancer as confirmed by endoscopy according to age (+/-2 y), sex, date of colonoscopy examination (+/-2 wk), and endoscopist. Main Outcome was the prevalence of colorectal neoplasia diagnosed by colonoscopy.


RESULTS
A significantly higher colorectal cancer prevalence was found in the gastric cancer group, that is, 19 of 543 (3.5%) versus 14 of 1086 (1.3%; P<0.001). The odds of developing colorectal cancer were higher in the presence of gastric cancer (odds ratios, 3.46; 95% confidence interval: 1.51-7.91). Four of the 119 (3.4%) gastric cancer patients below 50 years of age had colorectal cancer in contrast with no cases in the matched controls. The prevalence of colorectal adenoma was higher in the gastric cancer group, with a prevalence of 215 in 543 (39.6%) versus 311 in 1086 (28.6%; P<0.001). The risk of adenoma was also greater among gastric cancer patients (odds ratios, 1.76; 95% confidence interval: 1.34-2.25).


CONCLUSIONS
Our data reveal a higher prevalence and risk of colorectal cancer in patients diagnosed with gastric cancer, particularly in patients below 50 years of age. Additional studies are needed to explore the geographical differences in the association between gastric cancer and colon cancer.
Park
Dong Il
DI
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, South Korea.
Park
Seung Ha
SH
Yoo
Tae Woo
TW
Kim
Hyun Soo
HS
Yang
Suk-Kyun
SK
Byeon
Jeong-Sik
JS
Koh
Bong Min
BM
Kim
Jin Oh
JO
Shim
Ki-Nam
KN
Jeen
Yoon Tae
YT
Lee
Bo In
BI
Choi
Kyu Yong
KY
Lee
Hang Lak
HL
Han
Dong Soo
DS
Baek
Ilhyun
I
Park
Cheol Hee
CH
Park
Seun Ja
SJ
D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D004724:Endoscopy; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D015995:Prevalence; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000473:pathology*