Nitric oxide production in acute gastroenteritis in Indian children.
This study compared nitric oxide (NO) levels in 110 children with, and 110 children without, infectious gastroenteritis. Post-infection intestinal function was assessed in a subset. At least one pathogen was identified in 47.2% of cases. The most common diarrhoeal pathogens were rotavirus (22.7%) and norovirus genogroup II (11.8%). The levels of NO measured by median urinary nitrite:creatinine ratio were significantly higher in children with diarrhoea [23.6; interquartile range (IQR) 12.3-46.7] than without diarrhoea (7.8; IQR 4.1-13.2), P<0.001. The ratio was not significantly different between diarrhoeal cases with and without pathogens (P=0.148). Six of twelve children tested had intestinal dysfunction.
Sowmyanarayanan
Thuppal Varadachari
TV
Department of Gastrointestinal Sciences, Christian Medical College, Tamil Nadu, India.
Natarajan
Sathish Kumar
SK
Ramachandran
Anup
A
Sarkar
Rajiv
R
Moses
Prabhakar Devarajan
PD
Simon
Anna
A
Agarwal
Indira
I
Christopher
Solomon
S
Kang
Gagandeep
G
D000208:Acute Disease; D000367:Age Factors; D016022:Case-Control Studies; D002675:Child, Preschool; D003967:Diarrhea / Q000382:microbiology / Q000652:urine*; D004405:Dysentery, Bacillary / Q000652:urine*; D005759:Gastroenteritis / Q000382:microbiology / Q000652:urine*; D006801:Humans; D007194:India; D007223:Infant; D007408:Intestinal Absorption; D009569:Nitric Oxide / Q000652:urine*; D029322:Norovirus / Q000302:isolation & purification; D012401:Rotavirus / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000652:urine*; D012720:Severity of Illness Index; D012760:Shigella / Q000302:isolation & purification
D009569:Nitric Oxide