Dual-responsive supramolecular hydrogels from water-soluble PEG-grafted copolymers and cyclodextrin.
Novel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with alpha-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery.
Ren
Lixia
L
Beijing National Laboratory for Molecular Science, Division of Polymer Science and Materials, Institute of Chemistry, The Chinese Academy of Science, Beijing 100190, China.
He
Lihong
L
Sun
Tongchen
T
Dong
Xia
X
Chen
Yongming
Y
Huang
Jin
J
Wang
Chun
C
D001672:Biocompatible Materials / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005452:Fluoresceins / Q000737:chemistry / Q000378:metabolism; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism; D013696:Temperature; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D003505:Cyclodextrins; D004337:Drug Carriers; D005452:Fluoresceins; D020100:Hydrogels; D011108:Polymers; D014867:Water; C039083:5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)fluorescein; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols