title: Clinical effectiveness of online computerised cognitive-behavioural therapy without support for depression in primary care: randomised trial.
abstract: BACKGROUND
  Computerised cognitive-behavioural therapy (CCBT) might offer a solution to the current undertreatment of depression.
  
  
  OBJECTIVE
  To determine the clinical effectiveness of online, unsupported CCBT for depression in primary care.
  
  
  METHODS
  Three hundred and three people with depression were randomly allocated to one of three groups: Colour Your Life; treatment as usual (TAU) by a general practitioner; or Colour Your Life and TAU combined. Colour Your Life is an online, multimedia, interactive CCBT programme. No assistance was offered. We had a 6-month follow-up period.
  
  
  RESULTS
  No significant differences in outcome between the three interventions were found in the intention-to-treat and per protocol analyses.
  
  
  CONCLUSIONS
  Online, unsupported CCBT did not outperform usual care, and the combination of both did not have additional effects. Decrease in depressive symptoms in people with moderate to severe depression was moderate in all three interventions. Online CCBT without support is not beneficial for all individuals with depression.
authors: Erasmus Medical Centre, Department of Medical Psychology and Psychotherapy, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands. l.e.degraaf@erasmusme.nl
authors: L E
authors: LE
authors: de Graaf
authors: S A H
authors: SA
authors: Gerhards
authors: A
authors: A
authors: Arntz
authors: H
authors: H
authors: Riper
authors: J F M
authors: JF
authors: Metsemakers
authors: S M A A
authors: SM
authors: Evers
authors: J L
authors: JL
authors: Severens
authors: G
authors: G
authors: Widdershoven
authors: M J H
authors: MJ
authors: Huibers
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003866:Depressive Disorder / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020407:Internet; D008297:Male; D008875:Middle Aged; D011320:Primary Health Care; D013813:Therapy, Computer-Assisted; D016896:Treatment Outcome; D055815:Young Adult