Purification of dialysis water in the central dialysis fluid delivery system in Japan: a prospective observation study.
Whereas the main measure of dialysis fluid purity is endotoxin (ET) activity in Japan, it is the viability count in Western countries. Because of this difference, little information is available concerning dialysis fluid purity determined in terms of viability count in Japan. Under these circumstances a fact-finding investigation was planned and conducted concerning dialysis fluid purity to demonstrate the effectiveness of dialysis fluid purification measures. 93 medical institutions are equipped with the central dialysis fluid delivery system (CDDS) unique to Japan. Almost all medical institutions surveyed have achieved the purification level of ultrapure dialysis fluid after ETRF, but the methods of ETRF use and management widely vary with each institution so that early validation of the methods of evaluation of ET inhibition and system management is in urgent need. It is also important that simple universal microbial monitoring and purification procedures be diffused far and wide as suggested by the Purification Guidelines proposed by us.
Uchino
Junji
J
Working Group for Dialysis Fluid, Blood Purification Standardization Committee, Chiba City, Japan. KYK00105@nifty.ne.jp
Kawasaki
Tadayuki
T
D015314:Dialysis Solutions / Q000302:isolation & purification*; D004731:Endotoxins / Q000302:isolation & purification; D006801:Humans; D007564:Japan; D017410:Practice Guidelines as Topic; D011786:Quality Control; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods*; D014871:Water Microbiology
D015314:Dialysis Solutions; D004731:Endotoxins