HER-2/neu (c-erbB-2) oncoprotein in hyperplastic endometrial polyps detected in two cats.
The presence of HER-2/neu (c-erbB-2) oncoprotein, oestrogen-alpha receptor (ER), and progesterone receptor (PR) in hyperplastic endometrial polyps (EPs) of two cats with cystic endometrial hyperplasia-pyometra (CEH-P) complex was investigated. Immunohistochemistry assay for ER, PR and c-erbB-2 oncoprotein in the glandular and stromal tissue of the EPs was performed. ER and c-erbB-2 immunoreactivity was observed in the glandular epithelium of the EPs whereas PR immunoreactivity was detected only in the stromal fibroblasts. The c-erbB-2 oncoprotein may play a role with the ER in the pathogenesis of the hyperplastic EPs, although the role of this oncoprotein in the pathogenesis of EPs has yet to be determined.
Misirlioglu
Deniz
D
Department of Pathology, Faculty of Veterinary Medicine, Uludag University, Bursa, Turkey. denizy@uludag.edu.tr
Nak
Deniz
D
Ozyigit
Musa Ozgur
MO
Nak
Yavuz
Y
Akkoc
Ahmet
A
D000818:Animals; D002371:Cat Diseases / Q000503:physiopathology*; D002415:Cats; D004714:Endometrial Hyperplasia / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D015513:Oncogene Proteins; D011127:Polyps / Q000000981:diagnostic imaging / Q000662:veterinary*; D055112:Pyometra / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging
D015513:Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone