Enantioselective Rh-catalyzed hydrogenation of 3-aryl-2-phosphonomethylpropenoates by a new class of chiral ferrocenyl diphosphine ligands.
A new class of chiral ferrocenyl diphosphine ligands with an imidazole ring, (R(c),S(Fc))-ImiFerroPhos, has been prepared from acylferrocenes through a five-step transformation and successfully applied in the Rh-catalyzed asymmetric hydrogenation of various 3-aryl-substituted 2-phosphonomethylpropenoates, in which a series of chiral 3-phosphono-2-arylmethylpropanoic acid derivatives were achieved in ee values of up to 98%.
Wang
Dao-Yong
DY
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Hu
Xiang-Ping
XP
Hou
Chuan-Jin
CJ
Deng
Jun
J
Yu
Sai-Bo
SB
Duan
Zheng-Chao
ZC
Huang
Jia-Di
JD
Zheng
Zhuo
Z
D002384:Catalysis; D018360:Crystallography, X-Ray; D006865:Hydrogenation; D007093:Imidazoles / Q000737:chemistry*; D008024:Ligands; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D007093:Imidazoles; D008024:Ligands; D063065:Organophosphonates; D012238:Rhodium