Functional significance of nonspatial information in monkey lateral intraparietal area.
Although the parietal cortex is traditionally associated with spatial perception and motor planning, recent evidence shows that neurons in the lateral intraparietal area (LIP) carry both spatial and nonspatial signals. The functional significance of the nonspatial information in the parietal cortex is not understood. To address this question, we tested the effect of unilateral reversible inactivation of LIP on three behavioral tasks known to evoke nonspatial responses. Each task included a spatial component (target selection in the hemifield contralateral or ipsilateral to the inactivation) and a nonspatial component, namely limb motor planning, the estimation of elapsed time, and reward-based decisions. Although inactivation reliably impaired performance on all tasks, the deficits were spatially specific (restricted to contralateral target locations), and there were no effects on nonspatial aspects on performance. This suggests that modulatory nonspatial signals in LIP represent feedback about computations performed elsewhere rather than a primary role of LIP in these computations.
Balan
Puiu F
PF
Department of Neuroscience, Columbia University, New York, New York 10032, USA.
Gottlieb
Jacqueline
J
D000704:Analysis of Variance; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects / Q000502:physiology; D003657:Decision Making / Q000187:drug effects / Q000502:physiology; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D018755:GABA Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D008253:Macaca mulatta; D008845:Microinjections; D009118:Muscimol / Q000008:administration & dosage / Q000494:pharmacology*; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012201:Reward; D013028:Space Perception / Q000187:drug effects / Q000502:physiology*; D014796:Visual Perception / Q000187:drug effects / Q000502:physiology
D018755:GABA Agonists; D009118:Muscimol