A real-time photoacoustic tomography system for small animals.
A real-time 512-element photoacoustic tomography system for small animal imaging using a ring ultrasound array has been developed. The system, based upon a 5 MHz transducer array formed along a 50 mm circular aperture, achieves sub-200 micron lateral resolution over a 2 cm disk-shaped region. Corresponding elevation resolutions of 0.6 to 2.5 mm over the central volume enable depth-resolved 3D tomographic imaging with linear translation. Using 8:1 electronic multiplexing, imaging at up to 8 frame/sec is demonstrated for both dynamic phantoms and in vivo mouse and brain samples. The real-time, full 2D tomographic capability of the system paves the way for functional photoacoustic tomographic imaging studies in small animals with sub-second time frame.
Gamelin
John
J
Department of Electrical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Maurudis
Anastasios
A
Aguirre
Andres
A
Huang
Fei
F
Guo
Puyun
P
Wang
Lihong V
LV
Zhu
Quing
Q
D000162:Acoustics; D000818:Animals; D001921:Brain / Q000473:pathology*; D003199:Computer Systems; D003952:Diagnostic Imaging / Q000379:methods; D004867:Equipment Design; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D051379:Mice; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D014054:Tomography / Q000379:methods*