The effects of 201Tl myocardial perfusion scintigraphy studies on oxidative damage in patients.
The aim of this study was to investigate gamma radiation-induced oxidative damage in erythrocytes after 201Tl myocardial perfusion scintigraphy. Twenty patients (8 women and 12 men) who performed 201Tl myocardial perfusion scintigraphy were included in this study. The blood samples were taken from patients just before, 1 hour after and three hours after injection of the radiopharmaceutical. Malondialdehyde (MDA) and antioxidant enzymes such as glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT) levels were measured to evaluate the gamma radiation induced oxidative damage. The enzyme activities of SOD, GPX and CAT were decreased 1 hour after (p = 0.042, p = 0.697 and p = 0.653 respectively) and 3 hours after (p = 0.003, p = 0.573 and p = 0.002 respectively) injection of the radiopharmaceutical. Malondialdehyde levels were increased 1 hour after (p = 0.10) and 3 hours after (p = 0.47) injection of the radiopharmaceutical. In this study, we found that radiation due to 201Tl myocardial perfusion scintigraphy decreased the erythrocyte antioxidant levels and increased MDA levels.
Cicek
E
E
Department of Physics, Faculty of Arts and Science, Mehmet Akif Ersoy University, Burdur, Turkey. ekrcicek@yahoo.com
Yildiz
M
M
Delibas
N
N
Bahçeli
S
S
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002374:Catalase / Q000097:blood; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000201:enzymology; D004912:Erythrocytes / Q000528:radiation effects*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013482:Superoxide Dismutase / Q000097:blood; D013794:Thallium Radioisotopes
D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase