Cytotoxic bisnor- and norditerpene dilactones having 7alpha,8alpha-epoxy-9,11-enolide substructure from Podocarpus macrophyllus D. DON.
Fourteen new bisnor- and norditerpene dilactones, makilactones E-R, having a 7alpha : 8alpha-epoxy-9,11-enolide substructure, were isolated from a methanolic extract of the root and the bark of Podocarpus macrophyllus D. DON (Podocarpaceae) with thirteen known bisnor- and norditerpenoids, and the structures of those new bisnor- and norditerpenoids were determined on the basis of their spectroscopic studies. Of the thirteen known ones isolated, the structures of two, i.e., podolactone B and inumakilactone B, were revised on the basis of X-ray crystallographic analysis and spectroscopic analysis. Many of the compounds of this type isolated in this study showed potent cytotoxic activities against P388 murine leukemia cells.
Sato
Kimihiko
K
School of Pharmacy, Tokyo University of Pharmacy & Life Science.
Inaba
Yasunori
Y
Park
Hyun-Sun
HS
Akiyama
Toshiyuki
T
Koyama
Tetsuo
T
Fukaya
Haruhiko
H
Aoyagi
Yutaka
Y
Takeya
Koichi
K
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008958:Models, Molecular; D008967:Molecular Biology; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*; D064028:Tracheophyta / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes