title: Isolation and characterization of xanthine oxidase inhibitory constituents of Pyrenacantha staudtii.
abstract: Six compounds have been isolated from the leaves of Pyrenacantha staudtii, two of which are new compounds. The new compounds have been characterized as kaempherol 3-O-beta-rhamnopyranosyl (1-->6)-beta-D-glucopyranoside (1) and 4-beta-glucopyranosyl-(2-furyl)-5-methy-1,2-glucopyranoside phenylmethanone (2). The known compounds are 3-pyridinecarboxylic acid (3), beta-sitosterol (4), sitosterol 3-O-beta-glucopyranoside (5) and taraxerol (6). Their structures were determined by spectroscopic and chemical evidences. The two new compounds together with 3-pyridinecarboxylic acid showed significant in vitro xanthine oxidase inhibitory activity. To the best of our knowledge, this is the first report of these compounds from this plant.
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria. faloabi25@yahoo.com
authors: Abiodun
authors: A
authors: Falodun
authors: Muhammad Irfan
authors: MI
authors: Qadir
authors: Muhammad Iqbal
authors: MI
authors: Chouldary
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009525:Niacin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D014969:Xanthine Oxidase / Q000378:metabolism*
chemical_list: C548271:4-beta-glucopyranosyl-(2-furyl)-5-methy-1,2-glucopyranoside phenylmethanone; D004791:Enzyme Inhibitors; D005960:Glucosides; D044949:Kaempferols; C548270:kaempherol 3-O-beta-rhamnopyranosyl (1-6)-beta-D-glucopyranoside; D009525:Niacin; D014969:Xanthine Oxidase