The subcellular distribution of MnSOD alters during sodium selenite-induced apoptosis.
It was reported that high doses of sodium selenite can induce apoptosis of cancer cells, but the molecular mechanisms are poorly understood. Manganese superoxide dismutase (MnSOD) converts superoxide radical to hydrogen peroxide within the mitochondrial matrix and is one of the most important antioxidant enzymes. In this study, we showed that 20 microM sodium selenite could alter subcellular distribution of MnSOD, namely a decrease in mitochondria and an increase in cytosol. The alteration of subcellular distribution of MnSOD is dependent on the production of superoxide induced by sodium selenite.
Guan
Liying
L
National Laboratory of Medical Molecular Biology, Institute of Basic Medicine Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Chinese Academy of Sciences, Beijing, China.
Jiang
Qian
Q
Li
Zhushi
Z
Huang
Fang
F
Ren
Yun
Y
Yang
Yang
Y
Xu
Caimin
C
D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D018922:HL-60 Cells; D006801:Humans; D019169:Jurkat Cells; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D018038:Sodium Selenite / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism / Q000494:pharmacology; D014018:Tissue Distribution / Q000187:drug effects; D014407:Tumor Cells, Cultured
D013481:Superoxides; D013482:Superoxide Dismutase; D018038:Sodium Selenite