title: A comparative assessment of synthetic ceramic bone substitutes with different composition and microstructure in rabbit femoral condyle model.
abstract: Various bone substitutes with improved biocompatibility have been developed. Because these products vary in composition and microstructure, it is difficult to understand each feature and make an appropriate selection. Three recently developed highly porous ceramic bone substitutes were evaluated, including two made of hydroxyapatite with different structures (Apaceram-AX: 85%-porosity with micropores, NEOBONE: 75%-porosity without micropores) and one composed of beta-tricalcium phosphate (OSferion: 75%-porosity with micropores) in a rabbit model. Apaceram-AX showed gradual degradation, while NEOBONE remaining intact. OSferion was almost completely degraded at 24 weeks. Numerous osteoclasts were detected in materials with micropores, whether Apaceram-AX or OSferion, but not in NEOBONE. These differences of biodegradability seemed to be related to the presence of micropores. The compressive strength of OSferion increased for several weeks and decreased at a level of cancellous bone. The strength of NEOBONE gradually increased and remained at the highest level among three. The strength of Apaceram-AX increased two to three times that of cancellous bone. Surprisingly, the strength of all materials declined during the initial 1 week, suggesting that great care should be taken in the early period after implantation. These findings may help surgeons to select an appropriate porous substitute based on understanding of their features.
authors: Department of Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Naomi
authors: N
authors: Yamasaki
authors: Department of Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Makoto
authors: M
authors: Hirao
authors: Department of Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Katsuhiko
authors: K
authors: Nanno
authors: Department of Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Kenjiro
authors: K
authors: Sugiyasu
authors: Department of Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Noriyuki
authors: N
authors: Tamai
authors: Department of Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Nobuyuki
authors: N
authors: Hashimoto
authors: Department of Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Hideki
authors: H
authors: Yoshikawa
authors: Department of Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan.
authors: Akira
authors: A
authors: Myoui
mesh_terms: D020341:Absorbable Implants; D015502:Absorptiometry, Photon; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density; D001846:Bone Development / Q000502:physiology; D018786:Bone Substitutes; D002130:Calcium Phosphates / Q000737:chemistry; D002516:Ceramics; D017886:Durapatite / Q000737:chemistry; D005269:Femur / Q000000981:diagnostic imaging / Q000254:growth & development*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D018919:Neovascularization, Physiologic / Q000502:physiology; D019736:Prostheses and Implants; D011817:Rabbits; D013499:Surface Properties; D014055:Tomography, Emission-Computed
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D017886:Durapatite; C018392:tricalcium phosphate