title: Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits.
abstract: The digallic acid obtained from the fruit Pistacia lentiscus exhibits an inhibitory activity against nitrofurantoine and B[a]P induced genotoxicity when tested by the SOS chromotest bacterial assay system in the presence of Escherichia coli PQ37 strain. The antioxidant activity of the tested compound was determined by its ability to scavenge the free radical ABTS(+), to inhibit the xanthine oxidase, involved in the generation of free radicals, and to inhibit the lipid peroxidation induced by H(2)O(2) in the K562 cell line. Our results revealed that digallic acid shows an important free radical scavenging activity towards the ABTS(+) radical (99%) and protection against lipid peroxidation (68%).
authors: Unité de Pharmacognosie/BiologieMoléculaire 99/UR/07 03, Faculté de Pharmacie/Médecine Dentaire de Monastir, Rue Avicenne, 5000 Monastir, Tunisia.
authors: Wissem
authors: W
authors: Bhouri
authors: Safa
authors: S
authors: Derbel
authors: Ines
authors: I
authors: Skandrani
authors: Jihed
authors: J
authors: Boubaker
authors: Ines
authors: I
authors: Bouhlel
authors: Mohamed B
authors: MB
authors: Sghaier
authors: Soumaya
authors: S
authors: Kilani
authors: Anne M
authors: AM
authors: Mariotte
authors: Marie G
authors: MG
authors: Dijoux-Franca
authors: Kamel
authors: K
authors: Ghedira
authors: Leila
authors: L
authors: Chekir-Ghedira
mesh_terms: D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles; D049109:Cell Proliferation / Q000187:drug effects; D053630:Depsides / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D016166:Free Radical Scavengers; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D020014:K562 Cells; D015227:Lipid Peroxidation; D015394:Molecular Structure; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D027927:Pistacia / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry; D013481:Superoxides; D013844:Thiazoles / Q000737:chemistry; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D016587:Antimutagenic Agents; D000975:Antioxidants; D052160:Benzothiazoles; D053630:Depsides; D016166:Free Radical Scavengers; D009153:Mutagens; D013451:Sulfonic Acids; D013844:Thiazoles; D013481:Superoxides; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C067648:digallic acid; D005707:Gallic Acid; D014969:Xanthine Oxidase