title: Synthesis of dimeric quinazolin-2-one, 1,4-benzodiazepin-2-one, and isoalloxazine compounds as inhibitors of amyloid peptides association.
abstract: The synthesis of dimeric compounds derived from quinazolin-2-one and 1,4-benzodiazepin-2-one possessing a piperazine or homopiperazine spacer was investigated. In addition, a piperazine spacered bis-isoalloxazine and a bis-riboflavin compound were prepared and their ability to interrupt the association of prion proteins and Alzheimer-specific Abeta peptides was investigated using a fast screening system based on flow cytometry. The bis-isoalloxazine 14 was identified as a new lead structure.
authors: Martin-Luther-Universität Halle-Wittenberg, Organische Chemie, Halle (Saale), Germany.
authors: Alexander
authors: A
authors: Barthel
authors: Lothar
authors: L
authors: Trieschmann
authors: Dieter
authors: D
authors: Ströhl
authors: Ralph
authors: R
authors: Kluge
authors: Gerald
authors: G
authors: Böhm
authors: René
authors: R
authors: Csuk
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology; D019281:Dimerization; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005415:Flavins / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D015394:Molecular Structure; D011328:Prions / Q000737:chemistry; D040081:Protein Array Analysis / Q000379:methods; D017433:Protein Structure, Secondary / Q000187:drug effects*; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D016229:Amyloid beta-Peptides; D001570:Benzodiazepinones; D005415:Flavins; D011328:Prions; D052999:Quinazolinones; C008173:isoalloxazine