Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells.
Malignant tumors are characterized by dysregulated cell growth and the metastasis of secondary tumors. Numerous studies have documented that osteopontin (OPN) plays a key role in regulating tumor progression and metastasis. Here, we show that the overexpression of OPN in human embryo kidney-293 cells significantly increases both the level of cell proliferation, by provoking the G(1)/S transition, and the level of cell migration in vitro. These findings suggest that augmented OPN contributes to cell growth and motility. Inhibiting OPN or the pathway it stimulates may therefore represent a novel approach for the treatment of primary tumors and associated metastases.
Liu
Ya-Jun
YJ
Beijing Jishuitan Hospital, Peking University, Beijing, 100035, PR China. yajun.liu001@gmail.com
Zhang
Dao-Qiang
DQ
Sui
Xiu-Mei
XM
Tian
Wei
W
D002453:Cell Cycle; D002460:Cell Line; D002465:Cell Movement; D049109:Cell Proliferation; D015870:Gene Expression; D006801:Humans; D007668:Kidney / Q000166:cytology* / Q000196:embryology / Q000378:metabolism*; D053495:Osteopontin / Q000235:genetics / Q000378:metabolism*
D053495:Osteopontin