Simultaneous occurrence of hepatitis C virus-associated glomerulonephritis and AL amyloidosis.
We report a 65-year-old male with hepatitis C virus (HCV)-associated glomerulonephritis (GN) and AL amyloidosis. This patient had a 14-year history of HCV infection with positive serum HCV RNA at presentation. Diagnosis of HCV-related GN was established using immunohistochemistry in which the HCV-NS3 antigen was mainly detected as granular deposition in glomerular mesangium. AL amyloidosis was determined by electron microscopy, positive Congo red staining and identification of lambda-chain in the kidney specimen and monoclonal IgG-lambda in serum and urine. Under immunoelectron microscopy, the HCV-NS3 antigen was found in electron-dense deposits, while lambda-chains appeared in the amyloid-like filaments.
Cao
Yali
Y
Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Ministry of Health of China, Beijing, People's Republic of China.
Zhang
Youkang
Y
Wang
Suxia
S
Zhao
Minghui
M
Zou
Wanzhong
W
D000368:Aged; D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005921:Glomerulonephritis / Q000150:complications* / Q000209:etiology / Q000473:pathology / Q000821:virology; D016174:Hepacivirus / Q000378:metabolism / Q000472:pathogenicity; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism / Q000473:pathology / Q000821:virology; D007674:Kidney Diseases / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008297:Male; D016253:Microscopy, Immunoelectron; D017361:Viral Nonstructural Proteins / Q000378:metabolism; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D000682:Amyloid; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; C518669:amyloid L, human