The relationship among neuregulin 1-stimulated phosphorylation of AKT, psychosis proneness, and habituation of arousal in nonclinical individuals.
BACKGROUND
Previous studies reported an association between weak habituation of skin conductance orienting response and psychosis proneness. The aim of this study was to investigate the relationship among neuregulin 1 (NRG1)-stimulated AKT phosphorylation (a putative marker of psychosis), orienting response habituation, delusional ideas, anxiety, and depression in nonclinical individuals.


METHODS
One hundred twenty individuals participated in the skin conductance measurements. Weak and strong habituators were compared on measures of NRG1-stimulated AKT phosphorylation in B lymphoblasts, delusional ideas, anxiety, and depression. The predictors of delusional ideas were determined by multiple regression analysis.


RESULTS
Weak habituators displayed higher levels of delusional ideas/anxiety and a lower ratio of phosphorylated AKT as compared with strong habituators. There were 3 significant predictors of delusional ideas: decreased habituation, NRG1-induced AKT phosphorylation, and anxiety. Age, gender, education, IQ, and depression did not predict delusional ideas.


CONCLUSIONS
These results suggest that decreased habituation of arousal, NRG1-induced AKT phosphorylation, and anxiety are related to delusional ideation in the general population.
Kéri
Szabolcs
S
Department of Psychiatry and Psychotherapy, Semmelweis University, Balassa u. 6., Budapest H1083, Hungary. keriszabolcs@psych.sote.hu
Seres
Imola
I
Kelemen
Oguz
O
Benedek
György
G
D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000378:metabolism*; D001143:Arousal; D003702:Delusions / Q000378:metabolism*; D003863:Depression / Q000378:metabolism*; D005260:Female; D005712:Galvanic Skin Response; D006185:Habituation, Psychophysiologic; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020890:Neuregulin-1 / Q000494:pharmacology*; D009483:Neuropsychological Tests; D009949:Orientation; D010766:Phosphorylation; D011237:Predictive Value of Tests; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D055815:Young Adult
D020890:Neuregulin-1; D051057:Proto-Oncogene Proteins c-akt