title: The effect of HIV on filarial-specific antibody response before and after treatment with diethylcarbamazine in Wuchereria bancrofti infected individuals.
abstract: The effect of HIV on filarial-specific antibody response before and after treatment with diethylcarbamazine (DEC) was analysed by comparing two groups of Wuchereria bancrofti-infected adult individuals (positive for circulating filarial antigen) who were positive (n=15) or negative (n=21) for HIV co-infection. Prior to DEC treatment there was no significant difference in filarial-specific IgG1, IgG2, IgG4 and IgE antibody response between the HIV negative and the HIV positive group, while a five times (statistically significant) higher filarial-specific IgG3 response was observed in the HIV positive than in the HIV negative group. At 12 weeks after treatment with DEC, a significant decrease in filarial-specific IgG4 was observed in the HIV positive but not in the HIV negative group, indicating that DEC treatment had a stronger antifilarial effect in individuals co-infected with HIV. DEC treatment had no significant effect on the other classes of filarial specific antibodies, neither in the HIV negative or the HIV positive group.
authors: DBL-Centre for Health Research and Development, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark.
authors: Heidi H
authors: HH
authors: Petersen
authors: Nina O
authors: NO
authors: Nielsen
authors: Jesper
authors: J
authors: Monrad
authors: Stephen M
authors: SM
authors: Magesa
authors: Paul E
authors: PE
authors: Simonsen
mesh_terms: D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000918:Antibody Specificity; D018791:CD4 Lymphocyte Count; D004049:Diethylcarbamazine / Q000627:therapeutic use*; D004605:Elephantiasis, Filarial / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D005260:Female; D005369:Filaricides / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000502:physiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D014958:Wuchereria bancrofti / Q000276:immunology*; D055815:Young Adult
chemical_list: D000909:Antibodies, Helminth; D005369:Filaricides; D007074:Immunoglobulin G; D004049:Diethylcarbamazine