title: Indications for combined liver and kidney transplantation in children.
abstract: A significant number of patients awaiting liver transplantation have associated renal failure and renal dysfunction is associated with increased morbidity and mortality after LT. There has been a recent increase in the number of CLKT in adults. The common indications for CLKT in children are different from those of adults and include metabolic diseases affecting the kidney with or without liver dysfunction and congenital developmental abnormalities affecting both organs. The results are generally encouraging among these groups of patients. Early evaluation and listing of patients before they become severely ill or have major systemic manifestations of their metabolic problem are important.
authors: Institute of Liver Studies, Kings College London School of Medicine, King's College Hospital, London, UK.
authors: Srinivas P
authors: SP
authors: Chava
authors: Balbir
authors: B
authors: Singh
authors: Sujoy
authors: S
authors: Pal
authors: Anil
authors: A
authors: Dhawan
authors: Nigel D
authors: ND
authors: Heaton
mesh_terms: D002648:Child; D006085:Graft Survival; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000628:therapy; D015994:Incidence; D007668:Kidney / Q000002:abnormalities; D007674:Kidney Diseases / Q000601:surgery / Q000628:therapy*; D016030:Kidney Transplantation / Q000379:methods*; D008099:Liver / Q000002:abnormalities; D008107:Liver Diseases / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods*; D008765:Methylmalonyl-CoA Mutase / Q000172:deficiency; D010372:Pediatrics / Q000379:methods; D016896:Treatment Outcome
chemical_list: D008765:Methylmalonyl-CoA Mutase