Anal pressure in experimental diabetes.
OBJECTIVE
Diabetes mellitus is a metabolic endocrine disorder that affects many systems, the gastrointestinal system often being among the affected systems. This experimental study work was designed to demonstrate altered anal sphincter pressures in an experimental model of diabetes mellitus (DM).


METHODS
Male Wistar rats (mean weight = 250 g) were used and randomized in two groups (n = 10): CO = control and DM. DM was induced by administering a single dose of streptozotocin. Glycemic levels were measured at the start (time = 0) and end (time = 60) of the experiment and anorectal manometry at the end.


RESULTS
DM rats presented a significant increase in glycemia at day 60 (DM = 407.14 +/- 73.76) as compared to the control group (time 0 = 175.7 +/- 18.62 and time 60 = 198.04 +/- 28.66). Anorectal manometry showed a significant decrease in anal pressure in the DM group at day 60 (DM = 34.2 +/- 4.97) as compared to the CO group at the same time (CO = 67.4 +/- 2.06), with P < 0.01 and P < 0.001 (Student's t test).


CONCLUSIONS
The results suggest that DM, due to the high glycemic levels, lead to alterations such as anal sphincter hypotony, which may cause complications such as fecal incontinence.
Tieppo
Juliana
J
Laboratory of Experimental Hepatology-Physiology, Hospital de Clínicas de Porto Alegr (HCPA)/Federal University of Rio Grande do Sul (UFRGS), Rio Grande do Sul, Brazil.
Kretzmann Filho
Nélson A
NA
Seleme
Maura
M
Fillmann
Henrique S
HS
Berghmans
Bary
B
Possa Marroni
Norma
N
D001003:Anal Canal / Q000503:physiopathology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D008365:Manometry; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose