A simple method for assessing analgesic requirements and efficacy in rodents.
Evaluation of pain in the clinical setting is an ongoing challenge for veterinarians, researchers and IACUCs. Behavioral assessment, a common technique for evaluating pain, is subjective and difficult to translate into quantifiable data. The authors propose measuring changes in body weight, food consumption and water consumption as a simple and objective method for evaluating postsurgical pain and analgesic efficacy in rodents.
Wheat
Nathan J
NJ
Covance Inc., Greenfield, IN, USA.
Cooper
Dale M
DM
D000698:Analgesia / Q000009:adverse effects / Q000379:methods / Q000662:veterinary*; D000700:Analgesics / Q000009:adverse effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D007756:Laboratory Animal Science / Q000379:methods*; D051379:Mice; D010146:Pain / Q000517:prevention & control / Q000662:veterinary*; D010147:Pain Measurement; D051381:Rats; D013522:Surgery, Veterinary / Q000379:methods*
D000700:Analgesics