title: Nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy in 2007: general view of the pathogens' antibacterial susceptibility.
abstract: For the purpose of a nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens in patients in Japan, the Japanese Society of Chemotherapy conducted their second year survey, during the period from January to August, 2007. A total of 1178 strains were collected from clinical specimens obtained from adult patients with well-diagnosed respiratory tract infections. Susceptibility testing was evaluable for 1108 strains (226 Staphylococcus aureus, 257 Streptococcus pneumoniae, 6 Streptococcus pyogenes, 206 Haemophilus influenzae, 120 Moraxella catarrhalis, 122 Klebsiella pneumoniae, and 171 Pseudomonas aeruginosa). A total of 44 antibacterial agents, including 26 beta-lactams (four penicillins, three penicillins in combination with beta-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), three aminoglycosides, four macrolides (including ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standards Institute (CLSI). The incidence of methicillinresistant Staphylococcus aureus (MRSA) was high, at 59.7%, and the incidences of penicillin-intermediateresistant and -resistant Streptococcus pneumoniae (PISP and PRSP) were 30.4% and 5.1%, respectively. Among Haemophilus influenzae strains, 19.9% of them were found to be beta-lactamase-non-producing ampicillin (ABPC)-intermediately-resistant (BLNAI), 29.1% to be beta-lactamasenon-producing ABPC-resistant (BLNAR), and 6.7% to be beta-lactamase-producing ABPC-resistant (BLPAR) strains. Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae was not isolated. Two isolates (1.2%) of Pseudomonas aeruginosa were found to be metallo-beta-lactamase-producing strains, including one (0.6%) suspected multidrug-resistant strain showing resistance to imipenem, amikacin, and ciprofloxacin. These data will be a useful reference for future periodic surveillance studies and for investigations to control resistant infections as well. Continued surveillance is required to prevent the further spread of these antimicrobial resistances.
authors: The JSC Surveillance Committee, Japanese Society of Chemotherapy, Nichinai Kaikan B1, 3-28-8 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. niki@med.showa-u.ac.jp
authors: Y
authors: Y
authors: Niki
authors: H
authors: H
authors: Hanaki
authors: T
authors: T
authors: Matsumoto
authors: M
authors: M
authors: Yagisawa
authors: S
authors: S
authors: Kohno
authors: N
authors: N
authors: Aoki
authors: A
authors: A
authors: Watanabe
authors: J
authors: J
authors: Sato
authors: R
authors: R
authors: Hattori
authors: M
authors: M
authors: Terada
authors: N
authors: N
authors: Koashi
authors: T
authors: T
authors: Kozuki
authors: A
authors: A
authors: Maruo
authors: K
authors: K
authors: Morita
authors: K
authors: K
authors: Ogasawara
authors: Y
authors: Y
authors: Takahashi
authors: J
authors: J
authors: Watanabe
authors: K
authors: K
authors: Takeuchi
authors: S
authors: S
authors: Fujimura
authors: H
authors: H
authors: Takeda
authors: H
authors: H
authors: Ikeda
authors: N
authors: N
authors: Sato
authors: K
authors: K
authors: Niitsuma
authors: M
authors: M
authors: Saito
authors: S
authors: S
authors: Koshiba
authors: M
authors: M
authors: Kaneko
authors: M
authors: M
authors: Miki
authors: S
authors: S
authors: Nakanowatari
authors: Y
authors: Y
authors: Honda
authors: J
authors: J
authors: Chiba
authors: H
authors: H
authors: Takahashi
authors: M
authors: M
authors: Utagawa
authors: T
authors: T
authors: Kondo
authors: A
authors: A
authors: Kawana
authors: H
authors: H
authors: Konosaki
authors: Y
authors: Y
authors: Aoki
authors: H
authors: H
authors: Ueda
authors: H
authors: H
authors: Sugiura
authors: M
authors: M
authors: Ichioka
authors: H
authors: H
authors: Goto
authors: D
authors: D
authors: Kurai
authors: M
authors: M
authors: Okazaki
authors: K
authors: K
authors: Yoshida
authors: T
authors: T
authors: Yoshida
authors: Y
authors: Y
authors: Tanabe
authors: S
authors: S
authors: Kobayashi
authors: M
authors: M
authors: Okada
authors: H
authors: H
authors: Tsukada
authors: Y
authors: Y
authors: Imai
authors: Y
authors: Y
authors: Honma
authors: K
authors: K
authors: Nishikawa
authors: T
authors: T
authors: Yamamoto
authors: A
authors: A
authors: Kawai
authors: T
authors: T
authors: Kashiwabara
authors: Y
authors: Y
authors: Takesue
authors: Y
authors: Y
authors: Wada
authors: K
authors: K
authors: Nakajima
authors: T
authors: T
authors: Miyara
authors: H
authors: H
authors: Toda
authors: N
authors: N
authors: Mitsuno
authors: H
authors: H
authors: Sugimura
authors: S
authors: S
authors: Yoshioka
authors: M
authors: M
authors: Kurokawa
authors: Y
authors: Y
authors: Munekawa
authors: H
authors: H
authors: Nakajima
authors: S
authors: S
authors: Kubo
authors: Y
authors: Y
authors: Ohta
authors: K
authors: K
authors: Mikasa
authors: K
authors: K
authors: Maeda
authors: K
authors: K
authors: Kasahara
authors: A
authors: A
authors: Koizumi
authors: R
authors: R
authors: Sano
authors: S
authors: S
authors: Yagi
authors: M
authors: M
authors: Takaya
authors: Y
authors: Y
authors: Kurokawa
authors: N
authors: N
authors: Kusano
authors: E
authors: E
authors: Mihara
authors: M
authors: M
authors: Kuwabara
authors: Y
authors: Y
authors: Fujiue
authors: T
authors: T
authors: Ishimaru
authors: N
authors: N
authors: Matsubara
authors: Y
authors: Y
authors: Kawasaki
authors: H
authors: H
authors: Tokuyasu
authors: K
authors: K
authors: Masui
authors: K
authors: K
authors: Negayama
authors: N
authors: N
authors: Ueda
authors: M
authors: M
authors: Ishimaru
authors: Y
authors: Y
authors: Nakanishi
authors: M
authors: M
authors: Fujita
authors: J
authors: J
authors: Honda
authors: J
authors: J
authors: Kadota
authors: K
authors: K
authors: Hiramatsu
authors: Y
authors: Y
authors: Aoki
authors: Z
authors: Z
authors: Nagasawa
authors: M
authors: M
authors: Suga
authors: H
authors: H
authors: Muranaka
authors: K
authors: K
authors: Yanagihara
authors: J
authors: J
authors: Fujita
authors: M
authors: M
authors: Tateyama
authors: K
authors: K
authors: Sunakawa
authors: K
authors: K
authors: Totsuka
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000453:epidemiology / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents