title: Association among interleukin-6 gene polymorphism, diabetes and periodontitis in a Chinese population.
abstract: OBJECTIVE
  Diabetics significantly increase risk for periodontitis. Interleukin-6 (IL-6) gene polymorphism may play certain roles in the progression of periodontitis with diabetes. The purpose of this study was to assess the association among IL-6 gene polymorphisms, type 2 diabetes mellitus (T2DM) and chronic periodontitis (CP) in a Chinese population.
  
  
  METHODS
  DNA was obtained from 159 patients with CP, 88 patients with T2DM, 110 patients with CP&T2DM and 135 control subjects. The -174/-572/-597 polymorphisms of IL-6 gene were investigated by restriction fragment length polymorphism of polymerase chain reaction products. The results were further confirmed by sequencing. Significance was set at P < 0.008 after Bonferroni correction.
  
  
  RESULTS
  Among four groups, CP&T2DM group showed the lowest IL-6-572 CC genotype and C-allele frequencies (54.5% and 74.1%). In this regard, there were significant differences between CP&T2DM group and the control group [P = 0.006, odds ratio (OR) = 0.475, 95% CI: 0.279-0.808 and P = 0.002, OR = 0.502, 95% CI: 0.319-0.788 respectively]. Logistic regression with adjustment for age, gender, body mass index, smoking and stress showed no significant difference in terms of IL-6-572 genotypes (P = 0.058, OR= 0.523, 95% CI: 0.268-1.022).
  
  
  CONCLUSIONS
  The IL-6-572 genotype and allele distributions are unique to subjects with CP&T2DM in a Chinese population.
authors: Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou 510280, China.
authors: L M
authors: LM
authors: Xiao
authors: Y X
authors: YX
authors: Yan
authors: C J
authors: CJ
authors: Xie
authors: W H
authors: WH
authors: Fan
authors: D Y
authors: DY
authors: Xuan
authors: C X
authors: CX
authors: Wang
authors: L
authors: L
authors: Chen
authors: S Y
authors: SY
authors: Sun
authors: B Y
authors: BY
authors: Xie
authors: J C
authors: JC
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D055113:Chronic Periodontitis / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D048909:Diabetes Complications / Q000208:ethnology / Q000235:genetics / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006239:Haplotypes; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012016:Reference Values
chemical_list: D015850:Interleukin-6