title: Sudomotor, skin vasomotor, and cardiovascular reflexes in 3 clinical forms of Lewy body disease.
abstract: OBJECTIVE
  To elucidate the differences among dementia with Lewy bodies (DLB), Parkinson disease with dementia (PDD), and Parkinson disease without dementia (PD), with respect to the involvement of the autonomic nervous system, we clinically investigated the cutaneous and cardiovascular autonomic functions in patients with Lewy body disease.
  
  
  METHODS
  We studied 36 patients with Lewy body disorders, including 12 patients with DLB (age, 75.4 +/- 5.9 years), 12 patients with PDD (71.0 +/- 6.8 years), and 12 patients with PD (70.9 +/- 4.2 years), and 12 healthy control subjects (69.9 +/- 5.3 years). Sympathetic sweat response (SSwR) and skin vasomotor reflex (SkVR) on the palm were recorded to estimate the cutaneous sympathetic function, and the head-up tilt test was performed and coefficient of variation of R-R intervals (CV(R-R)) was studied to estimate the cardiovascular function.
  
  
  RESULTS
  The patients with DLB, patients with PDD, and patients with PD showed severely reduced SSwR amplitudes, significantly lower than that in the controls. The mean SkVR amplitudes in the patients with DLB and patients with PDD were significantly lower than that in the controls, but not in the patients with PD. The mean decreases in the systolic blood pressure during the head-up tilt test in the patients with DLB and patients with PDD were less than that in the controls. The mean CV(R-R) value was significantly lower in the patients with DLB.
  
  
  CONCLUSIONS
  Sudomotor function on the palm may be severely affected in Lewy body disorders, while skin vasomotor function and the cardiovascular system may be more severely affected in dementia with Lewy bodies and Parkinson disease with dementia than in Parkinson disease.
authors: Department of Neurology, Chiba University School of Medicine, Chiba, Japan.
authors: Y
authors: Y
authors: Akaogi
authors: M
authors: M
authors: Asahina
authors: Y
authors: Y
authors: Yamanaka
authors: Y
authors: Y
authors: Koyama
authors: T
authors: T
authors: Hattori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D002319:Cardiovascular System / Q000294:innervation / Q000503:physiopathology; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation / Q000502:physiology; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology; D012021:Reflex, Abnormal / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D012867:Skin / Q000098:blood supply / Q000294:innervation / Q000503:physiopathology; D013543:Sweat Gland Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D013545:Sweat Glands / Q000294:innervation / Q000503:physiopathology; D017779:Sympathetic Fibers, Postganglionic / Q000473:pathology / Q000503:physiopathology; D018667:Tilt-Table Test; D014666:Vasomotor System / Q000503:physiopathology