[Antibodies to enzymes of purine metabolism as a factor of gastrointestinal tract lesions in systemic scleroderma].
Antibodies to Adenosine Deaminase (AD) and Guanin Deaminase (GDA) were founded in sera of systemic sclerosis (SS) patients, their concentration positive correlated with activity of disease. Increased levels of antibodies to AD and GDA correlated with the severity of gastrointestinal tract injury (especially pancreatitis and hepatitis). It is shown that level of antibodies to AD and GDA differs reliable from contents of these antibodies, in sera of healthy persons. It is shown that AD enzymatic activity was decreased, while activity of GDA was increased. The antibodies to enzymes may be one of the possible causes of change of enzymes activity in sera of SS patients. The method of immunoenzyme determination of level of antibodies to AD, G on the basis of immobilized form of magnet sorbent was developed for immune diagnostics of SS.
Shilova
L N
LN
Gontar'
I P
IP
Zborovskaia
I A
IA
Moskvitina
O V
OV
D000243:Adenosine Deaminase / Q000276:immunology*; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D004066:Digestive System Diseases / Q000201:enzymology / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006148:Guanine Deaminase / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011687:Purines / Q000378:metabolism*; D012595:Scleroderma, Systemic / Q000150:complications / Q000201:enzymology / Q000276:immunology* / Q000378:metabolism
D001323:Autoantibodies; D011687:Purines; D006148:Guanine Deaminase; D000243:Adenosine Deaminase; C030985:purine