Platelets might mediate the increase of plasma glutamate in acute ischemic stroke: relevance for early neurological deterioration.
In this brief paper we would like to hypothesize that platelets might represent a "peripheral" contributory source for the elevation of plasma glutamate levels in the setting of acute ischemic stroke: available evidence and possible mechanisms will be discussed, especially drawing attention to the possible relevance for the pathophysiology of early neurological deterioration.
Tremolizzo
Lucio
L
Department of Neurology, San Gerardo Hospital, Monza, Italy. lucio.tremolizzo@unimib.it
Piazza
Fabrizio
F
Longoni
Marco
M
Ferrarese
Carlo
C
D000208:Acute Disease; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002545:Brain Ischemia / Q000150:complications* / Q000378:metabolism*; D018698:Glutamic Acid / Q000097:blood*; D006801:Humans; D008954:Models, Biological; D009422:Nervous System Diseases / Q000209:etiology* / Q000378:metabolism*; D020521:Stroke / Q000150:complications* / Q000378:metabolism*
D018698:Glutamic Acid