title: Bioactive triterpenoids from Callistemon lanceolatus.
abstract: A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC(50) value of 15.4 microM.
authors: School of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Korea.
authors: Wonsik
authors: W
authors: Jeong
authors: Seong Su
authors: SS
authors: Hong
authors: Nahyun
authors: N
authors: Kim
authors: Young Taek
authors: YT
authors: Yang
authors: Yu Su
authors: YS
authors: Shin
authors: Chul
authors: C
authors: Lee
authors: Bang Yeon
authors: BY
authors: Hwang
authors: Dongho
authors: D
authors: Lee
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D027822:Myrtaceae / Q000737:chemistry*; D009569:Nitric Oxide / Q000378:metabolism; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C542603:30-hydroxyalphitolic acid; D000893:Anti-Inflammatory Agents; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D014315:Triterpenes; D009569:Nitric Oxide