Synthesis of dimeric quinazolin-2-one, 1,4-benzodiazepin-2-one, and isoalloxazine compounds as inhibitors of amyloid peptides association.
The synthesis of dimeric compounds derived from quinazolin-2-one and 1,4-benzodiazepin-2-one possessing a piperazine or homopiperazine spacer was investigated. In addition, a piperazine spacered bis-isoalloxazine and a bis-riboflavin compound were prepared and their ability to interrupt the association of prion proteins and Alzheimer-specific Abeta peptides was investigated using a fast screening system based on flow cytometry. The bis-isoalloxazine 14 was identified as a new lead structure.
Barthel
Alexander
A
Martin-Luther-Universität Halle-Wittenberg, Organische Chemie, Halle (Saale), Germany.
Trieschmann
Lothar
L
Ströhl
Dieter
D
Kluge
Ralph
R
Böhm
Gerald
G
Csuk
René
R
D016229:Amyloid beta-Peptides / Q000737:chemistry; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology; D019281:Dimerization; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005415:Flavins / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D015394:Molecular Structure; D011328:Prions / Q000737:chemistry; D040081:Protein Array Analysis / Q000379:methods; D017433:Protein Structure, Secondary / Q000187:drug effects*; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000494:pharmacology
D016229:Amyloid beta-Peptides; D001570:Benzodiazepinones; D005415:Flavins; D011328:Prions; D052999:Quinazolinones; C008173:isoalloxazine