title: [Influence of modified qianjin huanglian pill on pancreas of mice with insulin resistance].
abstract: OBJECTIVE
  To investigate the influence of modified Qianjin Huanglian Pill (QJHL), a Chinese herbal compound, on pancreas in mice with monosodium L-glutamate (MSG) induced insulin resistance (IR) and its molecular mechanism.
  
  
  METHODS
  Controlled by rosiglitazone (Ros), the MSG indiced IR mice were treated with QJHL for 28 days. The laboratory indices were examined including fasting serum glucose (FSG), fasting serum insulin (FSI), insulin sensitivity index (ISI), and morphological changes of pancreas, and levels of insulin receptor (InsR), insulin receptor substrate (IRS1/2) and glucose transporter (GLUT2) mRNA expression in pancreas tissue were determined by the reverse transcriptase polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  As compared with the model group, the level of FSG was lower (P < 0.01) and ISI was higher (P < 0.05) after treatment in the QJHL treated group, with pancreatic islet hyperplasia and hypertrophy ameliorated significantly (P < 0.01). And these changes were similar to those in the Ros treated group (P > 0.05). Moreover, the level of GLUT2 mRNA expression in pancreas of the QJHL group increased significantly (P < 0.01), while it was unchanged in the Ros group.
  
  
  CONCLUSIONS
  QJHL could reduce IR, ameliorate pathological changes of pancreas, which is possibly related with its action on increasing GLUT2 mRNA expression in the pancreas tissue.
authors: Department of Traditional Chinese medicine, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing.
authors: Ai-ping
authors: AP
authors: Tian
authors: Chen-hui
authors: CH
authors: Zou
authors: Su-juan
authors: SJ
authors: Sun
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D051273:Glucose Transporter Type 2 / Q000235:genetics / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D051379:Mice; D008813:Mice, Inbred ICR; D010179:Pancreas / Q000378:metabolism / Q000473:pathology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012970:Sodium Glutamate
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D051273:Glucose Transporter Type 2; D007328:Insulin; D012333:RNA, Messenger; C543005:qianjin huanglian; D012970:Sodium Glutamate