Stem cell aging and aberrant differentiation within the niche.
Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes graying and loss of melanocyte stem cells by inducing premature differentiation, without inducing apoptosis or senescence.
Choi
Jinkuk
J
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Artandi
Steven
S
D000818:Animals; D002454:Cell Differentiation; D016922:Cellular Senescence; D004249:DNA Damage; D006197:Hair / Q000378:metabolism; D007763:Lac Operon; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000378:metabolism; D051379:Mice; D055153:Stem Cell Niche / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
D008543:Melanins