title: Role of double-balloon endoscopy in the diagnosis of small-bowel tumors: the first Japanese multicenter study.
abstract: BACKGROUND
  The early diagnosis of small-bowel tumors (SBT) was a difficult task until the advent of capsule endoscopy (CE) and double-balloon endoscopy (DBE) allowed access to the disease site. However, although CE and DBE have greatly simplified the task, DBE studies have yet to provide sufficient data on the diagnosis and outcome of patients with SBTs.
  
  
  OBJECTIVE
  To determine the efficacy of DBE examination in the detection and diagnosis of SBT.
  
  
  METHODS
  A retrospective analysis of cross-sectional case series.
  
  
  METHODS
  Seven major medical centers in Japan.
  
  
  METHODS
  The first 1035 consecutive DBE cases at these major Japanese centers since the introduction of DBE.
  
  
  METHODS
  The percentage of subjects with SBT and a diagnosis of SBT, their indications for DBE, and diagnostic and therapeutic DBE procedures carried out for SBT.
  
  
  RESULTS
  SBTs were identified in 144 of 1035 subjects (13.9%) who underwent DBE between September 2000 and December 2005. For subjects with SBT, the most common indication for DBE was the suspected presence of a SBT (61/144 [42.4%]). For subjects without SBT, the most common indication was obscure GI bleeding (OGIB) (419/891 [47.0%]). Malignant lymphoma and GI stromal tumor (GIST) were the most frequent (31/144 [21.5%]) and the second-most frequent SBTs (27/144 [18.8%]), respectively, in this database. We also performed 85 biopsies and 45 therapeutic procedures for the evaluation and treatment of SBTs in 144 patients. Although complications were encountered in 5.3% of cases (14/266 sessions), none of these were life threatening in the present study.
  
  
  CONCLUSIONS
  DBE proved a valuable tool for the detection and diagnosis of SBTs, especially when tumors were suspected. Biopsies and therapeutic procedures were also possible in most of these patients, which directed our management of the disease.
authors: Division of Gastroenterology, Department of Medicine, Nippon Medical School, Tokyo, Japan.
authors: Keigo
authors: K
authors: Mitsui
authors: Shu
authors: S
authors: Tanaka
authors: Hironori
authors: H
authors: Yamamoto
authors: Tsuyoshi
authors: T
authors: Kobayashi
authors: Akihito
authors: A
authors: Ehara
authors: Tomonori
authors: T
authors: Yano
authors: Hidemi
authors: H
authors: Goto
authors: Hiroshi
authors: H
authors: Nakase
authors: Shinji
authors: S
authors: Tanaka
authors: Toshiyuki
authors: T
authors: Matsui
authors: Mitsuo
authors: M
authors: Iida
authors: Kentaro
authors: K
authors: Sugano
authors: Choitsu
authors: C
authors: Sakamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D053705:Capsule Endoscopes; D053704:Capsule Endoscopy / Q000379:methods; D002404:Catheterization / Q000295:instrumentation*; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer; D020776:Endoscopes, Gastrointestinal; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D006801:Humans; D015994:Incidence; D007414:Intestinal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D007421:Intestine, Small / Q000473:pathology*; D007564:Japan; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D055815:Young Adult