title: In vivo hypoglycemic effects of phenolics from the root bark of Morus alba.
abstract: Moracin M (1), Steppogenin-4'-O-beta-D-glucosiade (2), Mullberroside A (3) were isolated from the root bark of Morus alba L. and identified by spectral evidence. Compounds 1, 2 and 3 were studied in hypoglycemic effects on alloxan-diabetic mice. The results showed that compounds 1, 2 and 3 all produced hypoglycemic effects. The compound 2 in a dose of 50 mg/kg exerted significant effect (p<0.05), 2 and 3 in a dose of 100 mg/kg exerted obviously effect (p<0.01). Meantime, the compound 1 in a dose of 100 mg/kg can make the fasting blood glucose level have decreasing tendency.
authors: Institute of Botany, Jiangsu Province & Chinese Academy of Sciences, Nanjing, PR China.
authors: Mi
authors: M
authors: Zhang
authors: Man
authors: M
authors: Chen
authors: Han-Qing
authors: HQ
authors: Zhang
authors: Shi
authors: S
authors: Sun
authors: Bing
authors: B
authors: Xia
authors: Fei-Hua
authors: FH
authors: Wu
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D031625:Morus / Q000737:chemistry*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010636:Phenols; D010936:Plant Extracts