Novel therapeutics based on tau/microtubule dynamics: WO2008084483.
BACKGROUND
The present patent deals with the generation of peptides derived from the activity-dependent peptide and tau mimetic to study its effect on microtubule stability, its ability to bind to tubulin and MAPs, as well as promoting cell survival.


OBJECTIVE
To analyze these peptides and their effects as potential therapeutic elements for neurodegenerative diseases.


METHODS
We review the action of the peptides described by Gozes and collaborators and compare the effectiveness with those already reported in the literature for Alzheimer's disease.


CONCLUSIONS
The research of Dr. Gozes and collaborators has shown that the addition of picomolar concentration of the peptides promotes cell survival, by interacting with tubulin and stabilizing the microtubules. Based on the results, these peptides seem to be very attractive candidates for therapeutical intervention in neurodegenerative diseases.
Alonso
Alejandra del Carmen
Adel C
The City University of New York, The Graduate Center, College of Staten Island, Center of Developmental Neurosciences and Developmental Disabilities, Department of Biology, NY 10314, USA. alonso@mail.csi.cuny.edu
Corbo
Christopher P
CP
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000503:physiopathology; D010330:Patents as Topic; D010455:Peptides / Q000494:pharmacology*; D011485:Protein Binding; D014404:Tubulin / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
D010455:Peptides; D014404:Tubulin; D016875:tau Proteins