title: Electro-acupuncture stimulation improves motor disorders in Parkinsonian rats.
abstract: Electro-acupuncture (EA) is believed to be effective for alleviating motor symptoms in patients with Parkinson's disease. In a rat hemiparkinsonian model induced by unilateral transection of the medial forebrain bundle (MFB), the effects of EA stimulation were investigated. EA stimulation at a high frequency (100 Hz) significantly reduced apomorphine-induced rotational behavior. Tyrosine hydroxylase immunohistochemical staining revealed that EA at 100 Hz protected axotomized dopaminergic neurons from degeneration in the substantia nigra (SN). Moreover, high frequency EA reversed the axotomy-induced decrease in substance P content and increase in glutamate decarboxylase-67 (GAD 67) mRNA level in the midbrain; however, it did not affect the axotomy-induced increase in enkephalin content in the globus pallidus. These results suggest that the effects of high frequency EA on motor symptoms of Parkinsonian rats may involve restoration of the homeostasis of dopaminergic transmission in the basal ganglia circuit.
authors: Department of Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing 100069, PR China.
authors: Jun
authors: J
authors: Jia
authors: ZuoLi
authors: Z
authors: Sun
authors: Bo
authors: B
authors: Li
authors: YanLi
authors: Y
authors: Pan
authors: HaoMin
authors: H
authors: Wang
authors: Xuan
authors: X
authors: Wang
authors: Fen
authors: F
authors: Yu
authors: LiMin
authors: L
authors: Liu
authors: LiJuan
authors: L
authors: Zhang
authors: XiaoMin
authors: X
authors: Wang
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000009:adverse effects; D001058:Apomorphine / Q000009:adverse effects; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D020820:Dyskinesias / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D015671:Electroacupuncture / Q000379:methods; D004745:Enkephalins / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008297:Male; D008474:Medial Forebrain Bundle / Q000293:injuries; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D020734:Parkinsonian Disorders / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012333:RNA, Messenger / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013373:Substance P / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D000978:Antiparkinson Agents; D004745:Enkephalins; D012333:RNA, Messenger; D013373:Substance P; D014446:Tyrosine 3-Monooxygenase; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1; D001058:Apomorphine; D004298:Dopamine