title: Impact of image reconstruction on phase analysis of ECG-gated myocardial perfusion SPECT studies.
abstract: OBJECTIVE
  Phase analysis (SyncTool) has been developed to assess left-ventricular (LV) dyssynchrony from gated myocardial perfusion single-photon emission computed tomography (GSPECT) studies. Conventionally, GSPECT data are reconstructed using filtered backprojection (FBP). This study is intended to determine the impact of various iterative reconstruction methods on SyncTool.
  
  
  METHODS
  Thirty consecutive patients, acquired using a Philips CardioMD system, were enrolled in this study. The GSPECT data were reconstructed using FBP, maximum likelihood expectation maximization (MLEM), MLEM with three-dimensional resolution recovery (Astonish), MLEM with Vantage attenuation correction (AC), and MLEM with Vantage AC and three-dimensional Monte Carlo-based scatter correction (ACSC), respectively. The reconstructed data were then submitted to SyncTool to measure LV dyssynchrony (phase standard deviation and histogram bandwidth). The paired t-test was used to compare the LV dyssynchrony indices given by MLEM, Astonish, AC, and ACSC, respectively, with those given by the FBP.
  
  
  RESULTS
  No statistical significance was observed for any comparison between iterative reconstruction methods and the FBP.
  
  
  CONCLUSIONS
  Reconstruction methods have insignificant impact on the LV dyssynchrony indices, indicating that the standard FBP reconstruction is sufficient for accurate phase analysis, supporting the widespread clinical use of SyncTool in measuring LV dyssynchrony.
authors: Division of Nuclear Cardiology, Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China. lidianfu@gmail.com
authors: Dianfu
authors: D
authors: Li
authors: Yanli
authors: Y
authors: Zhou
authors: Jianlin
authors: J
authors: Feng
authors: Donglan
authors: D
authors: Yuan
authors: Kejiang
authors: K
authors: Cao
authors: Ernest V
authors: EV
authors: Garcia
authors: Ji
authors: J
authors: Chen
mesh_terms: D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / Q000379:methods*; D004562:Electrocardiography / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D016013:Likelihood Functions; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*