title: Physicochemical investigation of the solid dispersion systems of etoricoxib with poloxamer 188.
abstract: Solid dispersion systems of a poorly water-soluble drug, etoricoxib were prepared with poloxamer 188 in 1:0.5, 1:1.5 and 1:2.5 ratios and evaluated by FTIR, powder XRD and dissolution studies. Physical studies demonstrated a strong hydrogen bonding with significant decrease in the crystallinity and formation of amorphous etoricoxib in its binary systems. All binary systems of etoricoxib showed faster dissolution than pure drug alone (P < 0.001). However, 1:2.5 proportion of etoricoxib: poloxamer 188 showed superior performance (DE45: 71.27% +/- 3.85) in enhancing solubility and dissolution rate of etoricoxib suggesting optimum ratio of the carrier.
authors: Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra, India.
authors: Poonam
authors: P
authors: Karekar
authors: Vikrant
authors: V
authors: Vyas
authors: Manali
authors: M
authors: Shah
authors: Pankajkumar
authors: P
authors: Sancheti
authors: Yogesh
authors: Y
authors: Pore
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D003460:Crystallization; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D000077613:Etoricoxib; D006860:Hydrogen Bonding; D020442:Poloxamer / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013450:Sulfones / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D004337:Drug Carriers; D011725:Pyridines; D013450:Sulfones; D020442:Poloxamer; D000077613:Etoricoxib