Bis-anthracenyl isoxazolyl amides have enhanced anticancer activity.
Dimeric analogs of Anthracenyl Isoxazole Amides (AIMs) (the designation AIM is in honor of the memory of Professor Albert I. Meyers) were prepared and dimer 6 exhibited the highest efficacy to date for this class of anti-tumor compounds against the human glioma Central Nervous System cell line SNB-19.
Gajewski
Mariusz P
MP
Department of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT 59812, USA.
Beall
Howard
H
Schnieder
Mark
M
Stranahan
Sarah M
SM
Mosher
Michael D
MD
Rider
Kevin C
KC
Natale
Nicholas R
NR
D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001932:Brain Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004247:DNA / Q000737:chemistry; D019281:Dimerization; D004354:Drug Screening Assays, Antitumor; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D008968:Molecular Conformation
D000577:Amides; D000970:Antineoplastic Agents; D004247:DNA