[Protective effect of puerarin on the secondary spinal cord injury in rats].
OBJECTIVE
To research the protective effect of puerarin on secondary spinal cord injury (SCI) in rats.


METHODS
After the models of SCI were established by improved Allen's method on adult male SD rats, SOD, MDA, Bcl-2 and Bax gene protein expression between puerarin group and model group were compared after 1, 6, 12, 24 and 48 h.


RESULTS
Puerarin could significantly enhance the activity of SOD and reduce the content of MDA, increase the expression of Bcl-2 gene protein products and decrease Bax gene protein product.


CONCLUSIONS
Puerarin can increase the activity of SOD, reduce the content of MDA, promote the expession of Bcl-2 and restrain the expression of Bax in the early spinal cord injury. It has protective effect on the secondary spinal cord injury.
Heng
Li-Song
LS
Second Department of Orthopaedics, Second Affiliated Hospital, Medical School, Xi' an Jiaotong University, Xi' an 710004, China. henglisong1214@stu.xjtu.cdu.cn
Lan
Bin-Shang
BS
Jia
Zhen
Z
Wang
Peng-Fei
PF
Fan
Li-Ying
LY
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry; D005786:Gene Expression Regulation / Q000187:drug effects; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000473:pathology*; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors; D051028:bcl-2-Associated X Protein / Q000378:metabolism
D000975:Antioxidants; D007529:Isoflavones; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D008315:Malondialdehyde; D013482:Superoxide Dismutase