Liver perfusion with dynamic multidetector-row computed tomography as an objective method to evaluate the efficacy of chemotherapy in patients with colorectal cancer.
A total of 24 liver metastases of colorectal cancer were evaluated by dynamic multiphasic CT. Under chemotherapy, follow-up examinations were performed every 3 months. The tumor marker CEA before vs. after chemotherapy correlated with the mean contrast enhancement within the margin of metastases. The total size of metastases correlated with the size of central necrosis as well as with the size of marginal contrast enhancement. CT is able to quantify perfusion and local activity of liver metastases to determine the efficacy of chemotherapy.
Pauls
Sandra
S
Department of Diagnostic and Interventional Radiology, University Hospitals of Ulm, Ulm, Germany. sandra.pauls@uni-ulm.de
Gabelmann
Andreas
A
Heinz
Wolfgang
W
Fröhlich
Eckhart
E
Juchems
Markus Sebastian
MS
Brambs
Hans-Jürgen
HJ
Schmidt
Stefan Andreas
SA
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging*; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D055420:Perfusion Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
D000970:Antineoplastic Agents