title: Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer.
abstract: Gold nanoparticles targeting epidermal growth factor receptor via antibody conjugation undergo molecular specific aggregation when they bind to receptors on cell surfaces, leading to a red shift in their plasmon resonance frequency. Capitalizing on this effect, we demonstrate the efficacy of the molecular specific photoacoustic imaging technique using subcutaneous tumor-mimicking gelatin implants in ex-vivo mouse tissue. The results of our study suggest that highly selective and sensitive detection of cancer cells is possible using multiwavelength photoacoustic imaging and molecular specific gold nanoparticles.
authors: Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA.
authors: Srivalleesha
authors: S
authors: Mallidi
authors: Timothy
authors: T
authors: Larson
authors: Justina
authors: J
authors: Tam
authors: Pratixa P
authors: PP
authors: Joshi
authors: Andrei
authors: A
authors: Karpiouk
authors: Konstantin
authors: K
authors: Sokolov
authors: Stanislav
authors: S
authors: Emelianov
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D045744:Cell Line, Tumor; D003952:Diagnostic Imaging / Q000379:methods*; D066246:ErbB Receptors / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis*; D020349:Surface Plasmon Resonance
chemical_list: D000911:Antibodies, Monoclonal; D006046:Gold; D066246:ErbB Receptors