[Dimethylarsinous acid-promoted skin tumorigenesis through the induction of oxidative stress in mice].
OBJECTIVE
To investigated the relationship between skin-tumor promotion and oxidative stress caused by dimethylated arsenic in mice.


METHODS
The experimental animal model was used to examine the effect of dimethylated arsenic, a metabolite of DMA(V), dimethylarsinous acid (DMA(III)) in skin tumorigenesis in mice. The 8-oxo-2'-deoxyguanosine (8-oxodG) analysis of epidermis was based on the method of HPLC.


RESULTS
When mice were topically treated with trivalent dimethylated arsenic (DMA(III)), a further reductive metabolite of DMA(V), not only an increase in skin tumors but also an elevation of 8-oxodG in epidermis were observed.


CONCLUSIONS
These results suggest that tumor promotion due to DMA(V) administration is mediated by DMA(III) through the induction of oxidative stress.
An
Yan
Y
Department of Toxicology, School of Radiation Medicine & Public Health Medical College, Soochow University, Suzhou 215123, China. dranyan@126.com
Li
Zhen
Z
Wang
Sanxiang
S
Wang
Zhenghui
Z
D000080242:8-Hydroxy-2'-Deoxyguanosine; D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D002101:Cacodylic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D018384:Oxidative Stress / Q000187:drug effects*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000378:metabolism
D002273:Carcinogens; C472511:dimethylarsinous acid; D015127:9,10-Dimethyl-1,2-benzanthracene; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002101:Cacodylic Acid; D003849:Deoxyguanosine