title: Gabapentin for the treatment of pain related to radiation-induced mucositis in patients with head and neck tumors treated with intensity-modulated radiation therapy.
abstract: BACKGROUND
  This retrospective study evaluates the efficacy of gabapentin for the treatment of pain syndrome related to radiation-induced mucositis in patients with head and neck tumors.
  
  
  METHODS
  Thirty cases of head and neck malignancies treated with radiotherapy were analyzed.
  
  
  RESULTS
  By using a median dose of 2700 mg/day of gabapentin, only 10% of patients required additional narcotic pain medications for adequate pain relief during the third and fourth week of treatment, despite grade 2 or higher mucositis present in 56% and 73% of the patients, respectively. Likewise, during the last weeks of intensity-modulated radiation therapy (IMRT), only 35% of patients required additional narcotics for pain control, despite the presence of grade 2 or higher mucositis in 80% of cases.
  
  
  CONCLUSIONS
  Gabapentin appears promising in reducing the need for narcotic pain medication for patients with head and neck malignancies treated with IMRT and should be further evaluated prospectively in controlled clinical trials.
authors: Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. barad@xrt.upenn.edu
authors: Voichita
authors: V
authors: Bar Ad
authors: Gregory
authors: G
authors: Weinstein
authors: Pinaki R
authors: PR
authors: Dutta
authors: Ara
authors: A
authors: Chalian
authors: Stefan
authors: S
authors: Both
authors: Harry
authors: H
authors: Quon
mesh_terms: D000588:Amines / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D003680:Deglutition Disorders / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D000077206:Gabapentin; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D052016:Mucositis / Q000145:classification / Q000188:drug therapy* / Q000209:etiology; D010146:Pain / Q000188:drug therapy*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects; D012189:Retrospective Studies; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
chemical_list: D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin