title: Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, isoenzyme, polypeptide and withanolide profile diversity.
abstract: Withania somnifera is one of the most important medicinal plants of Ayurveda and finds extensive uses in Indian traditional herbal preparations. In this investigation, selected accessions of the plant were examined for diversity through RAPDs, isoenzymes, polypeptide polymorphism and withanolide profiles. The accessions clustered together with respect to their characteristic profile of major withanolides and represented withaferin A, withanone, withanolide D or withanolide A rich groups. This level of phytochemical diversity as discrete chemotypes is widest and is being first ever documented to occur in Indian population of the plant.
authors: National Centre for Natural Products Research (NCNPR), School of Pharmacy, Thad Cochran Research Center, University of Mississippi, MS 38677, USA.
authors: Narayan D
authors: ND
authors: Chaurasiya
authors: Rajender S
authors: RS
authors: Sangwan
authors: Laxmi N
authors: LN
authors: Misra
authors: Rakesh
authors: R
authors: Tuli
authors: Neelam S
authors: NS
authors: Sangwan
mesh_terms: D018744:DNA, Plant; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D019105:Random Amplified Polymorphic DNA Technique; D032341:Withania / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D054358:Withanolides / Q000378:metabolism*
chemical_list: D018744:DNA, Plant; D007527:Isoenzymes; D010455:Peptides; D054358:Withanolides