Neuroblastoma originating from extra-abdominal sites: association with favorable clinical and biological features.
Neuroblastomas originating from different sites might have different clinical and biological characteristics. In the present study, the clinical (age, sex and stage) and biological (N-myc amplification, Shimada pathology and levels of lactate dehydrogenase, ferritin and neuron-specific enolase) characteristics of patients with newly diagnosed neuroblastoma were compared according to the site of tumor origin (extra-abdominal versus abdominal). The event-free survival rate (EFS) was also compared between the two groups. Among 143 neuroblastomas, 115 tumors originated from the abdomen, 26 from extra-abdominal sites and 2 from unknown primary sites. Frequencies of stage 4 tumor and N-myc amplified tumor were lower in the extra-abdominal group than in the abdominal group (34.6% vs. 60.0%, P=0.019 and 4.2% vs. 45.0%, P<0.001, respectively). Levels of lactate dehydrogenase, ferritin and neuron-specific enolase were significantly lower in the extra-abdominal group than in the abdominal group. The probability of 5-yr EFS (+/-95% confidence interval) was higher in the extra-abdominal group than in the abdominal group (94.4+/-10.6% vs. 69.4+/-9.4%, P=0.026). Taken together, neuroblastomas originating from extra-abdominal sites might be associated with more favorable clinical and biological characteristics and a better outcome than neuroblastomas originating from abdomen.
Sung
Ki Woong
KW
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Yoo
Keon Hee
KH
Koo
Hong Hoe
HH
Kim
Ju Youn
JY
Cho
Eun Joo
EJ
Seo
Yeon Lim
YL
Kim
Jhingook
J
Lee
Suk Koo
SK
D018572:Disease-Free Survival; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009447:Neuroblastoma / Q000175:diagnosis* / Q000628:therapy; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011379:Prognosis; D016896:Treatment Outcome; D014642:Vanilmandelic Acid / Q000652:urine
D014642:Vanilmandelic Acid; D005293:Ferritins; D007770:L-Lactate Dehydrogenase; D010751:Phosphopyruvate Hydratase