Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles.
Contrast in optical coherence tomography (OCT) images can be enhanced by utilizing surface plasmon resonant gold nanoparticles. To improve the poor in vivo transport of gold nanoparticles through biological barriers, an efficient delivery strategy is needed. In this study, the improved penetration and distribution of gold nanoparticles were achieved by microneedle and ultrasound, respectively, and it was demonstrated that this multimodal delivery of antibody-conjugated PEGylated gold nanoparticles enhanced the contrast in in vivo OCT images of oral dysplasia in a hamster model.
Kim
Chang Soo
CS
University of California, Irvine, Department of Chemical Engineering, Irvine, California 92697, USA.
Wilder-Smith
Petra
P
Ahn
Yeh-Chan
YC
Liaw
Lih-Huei L
LH
Chen
Zhongping
Z
Kwon
Young Jik
YJ
D000818:Animals; D002610:Cheek / Q000033:anatomy & histology; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics; D006224:Cricetinae; D016503:Drug Delivery Systems / Q000379:methods*; D004848:Epithelium / Q000033:anatomy & histology; D006046:Gold / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D007089:Image Enhancement / Q000379:methods; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D008845:Microinjections; D008954:Models, Biological; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012815:Signal Processing, Computer-Assisted; D041623:Tomography, Optical Coherence / Q000379:methods*; D014463:Ultrasonography
D003287:Contrast Media; D006046:Gold