Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda.
OBJECTIVE
To identify risk factors for in-hospital mortality in patients treated for visceral leishmaniasis (VL) in Uganda.


METHODS
Retrospective analysis of VL patients' clinical data collected for project monitoring by Médecins Sans Frontières in Amudat, eastern Uganda.


RESULTS
Between 2000 and 2005, of 3483 clinically suspect patients, 53% were confirmed with primary VL. Sixty-two per cent were children <16 years of age with a male/female ratio of 2.2. The overall case-fatality rate during pentavalent antimonial (n = 1641) or conventional amphotericin B treatment (n = 217) was 3.7%. There was no difference in the case-fatality rate between treatment groups (P > 0.20). The main risk factors for in-hospital death identified by a multivariate analysis were age <6 years and >15 years, concomitant tuberculosis or hepatopathy, and drug-related adverse events. The case-fatality rate among patients >45 years of age was strikingly high (29.0%).


CONCLUSIONS
Subgroups of VL patients at higher risk of death during treatment with drugs currently available in Uganda were identified. Less toxic drugs should be evaluated and used in these patients.
Mueller
Yolanda
Y
Médecins Sans Frontières, Geneva, Switzerland. yolanda.muller@geneva.msf.org
Mbulamberi
Dawson B
DB
Odermatt
Peter
P
Hoffmann
Axel
A
Loutan
Louis
L
Chappuis
François
F
D000293:Adolescent; D000328:Adult; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014454:Uganda / Q000453:epidemiology; D055815:Young Adult
D000981:Antiprotozoal Agents