Acute renal failure related to oxaliplatin-induced intravascular hemolysis.
Oxaliplatin is an effective chemotherapeutic agent frequently used in the treatment of colorectal carcinoma. Rare cases of renal failure and hemolytic reactions have been reported as separate side effects of oxaliplatin. Here we present a clinical picture of immune-related intravascular hemolysis and acute tubular necrosis in a patient receiving this drug. This case suggests a mechanistic explanation of renal failure in patients treated with oxaliplatin.
Ulusakarya
Ayhan
A
Department of Hematology/Oncology, Paul Brousse University Hospital, AP-HP, 12, Avenue Paul Vaillant Couturier, 94804, Villejuif, France. ayhan.ulusakarya@pbr.aphp.fr
Misra
Srimanta
S
Haydar
Mazen
M
Habert
Hélène
H
Castagne
Vincent
V
Gumus
Yusuf
Y
Delmas-Marsalet
Béatrice
B
Machover
David
D
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D000068818:Cetuximab; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D011379:Prognosis
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000068818:Cetuximab; D002955:Leucovorin; D005472:Fluorouracil