SAPHO syndrome in an adult with ulcerative colitis responsive to intravenous pamidronate: a case report and review of the literature.
Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare group of sterile, inflammatory osteoarticular disorders classically associated with skin lesions. It is occasionally associated with enteropathic disease such as ulcerative colitis. We present a 39-year-old patient with chronic ulcerative colitis who developed enteropathic SAPHO and responded well to pamidronate. We discuss the clinicopathological features with particular attention to bone pathology, and perform a literature review of this fascinating syndrome.
Siau
Keith
K
Department of Rheumatology, Musgrove Park Hospital, Taunton, TA1 5DA, UK. keith@siau.org
Laversuch
Catherine J
CJ
D020083:Acquired Hyperostosis Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D000328:Adult; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis*; D004164:Diphosphonates / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D000077268:Pamidronate; D016896:Treatment Outcome
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000077268:Pamidronate