title: [Study on the optimal extracion craft of Xiaochuang gel by central composite design-response surface methodology].
abstract: OBJECTIVE
  To optimize the extraction craft of Xiaochuang gel by central composite design-response surface methodology.
  
  
  METHODS
  The main influential factors of extraction effect included the quantity of ethanol, the concentration of ethanol and the extraction time. The conditions of the extraction were evaluated by the yield of the extracts and the total content of rheum emodin and chrysophanol. The optimal extraction craft of Xiaochuang gel was chosen by central composite design-response surface methodology.
  
  
  RESULTS
  The optimal conditions were extracting two times, two hours each time with ten volume multiples of 60% ethanol.
  
  
  CONCLUSIONS
  It is simple, convenient and highly predictive to optimize the extraction craft of Xiaochuang gel by central composite design-response surface methodology.
authors: Guangxi Traditional Chinese Medical University, Nanning 530001, China. weiwei690413@eyou.com
authors: Wei-Wei
authors: WW
authors: Chen
authors: Dong-Ying
authors: DY
authors: Xu
authors: Chao-Cheng
authors: CC
authors: Deng
authors: Kan
authors: K
authors: Feng
authors: Xiao-Yong
authors: XY
authors: Zhu
mesh_terms: D000880:Anthraquinones / Q000032:analysis*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D004642:Emodin / Q000032:analysis; D000431:Ethanol / Q000008:administration & dosage / Q000737:chemistry; D005782:Gels; D010946:Plants, Medicinal / Q000737:chemistry*; D012250:Rheum / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors
chemical_list: D000880:Anthraquinones; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005782:Gels; D012997:Solvents; D000431:Ethanol; D004642:Emodin