No evidence of intrauterine transmission of hepatitis A virus from a mother to a premature infant.
OBJECTIVE
To determine whether or not an intrauterine transmission of hepatitis A virus (HAV) occurred from an infected mother to her premature infant delivered by caesarean section.


METHODS
The mother and her child were tested for HAV by serology and reverse transcription PCR.


RESULTS
An outbreak of HAV infection was seen among children and a 33-year-old day-care teacher, pregnant in third trimester, at a day-care centre in southern Sweden. Due to premature labour and diminished foetal movements a caesarean section was performed and a premature girl in gestational weeks 33 + 1 was born. During the 3-week postnatal hospitalization period the child presented no clinical symptoms of HAV infection and anti-HAV IgM antibodies remained undetectable at day 14 and 109 after birth. Furthermore HAV RNA remained undetectable by reverse transcription PCR in the child's blood at birth and in throat and faeces for the first 3 and 4 weeks of life respectively. HAV RNA in the mother's blood was detected at 6 days prior to and at 17 days after delivery. HAV RNA was undetectable in breast milk when tested on day 3 after delivery.


CONCLUSIONS
There was no evidence of intrauterine transmission of hepatitis A virus from a viraemic mother to her premature child delivered at gestational week 33 + 1 by caesarean section.
Selander
Bo
B
Department of Clinical Sciences, Division of Paediatrics, Lund University Hospital, Lund, Sweden.
Bläckberg
Jonas
J
Widell
Anders
A
Johansson
P J Hugo
PJ
D000328:Adult; D005260:Female; D006506:Hepatitis A / Q000635:transmission*; D035922:Hepatitis A Antibodies / Q000097:blood; D030041:Hepatitis A virus / Q000302:isolation & purification; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D018445:Infectious Disease Transmission, Vertical; D008895:Milk, Human / Q000737:chemistry; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D011263:Pregnancy Trimester, Third; D012367:RNA, Viral / Q000032:analysis / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014766:Viremia
D035922:Hepatitis A Antibodies; D012367:RNA, Viral