Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection.
Virus infection may contribute to asthma pathogenesis. In turn, a Th2-polarized pulmonary environment may increase host susceptibility to infection. We used a cockroach antigen (CRA) model of allergic airway disease to test the hypothesis that Th2 cytokine overproduction increases susceptibility to mouse adenovirus type 1 (MAV-1). CRA sensitization led to upregulated lung expression of IL-4 and IL-13, lung cellular inflammation, and exaggerated airway mucus production. Following intranasal MAV-1 infection, lung cellular inflammation was more pronounced in CRA-sensitized mice than in unsensitized mice at 7 days post-infection but not at a later time point. CRA sensitization did not significantly suppress lung IFN-gamma expression, and lung IFN-gamma expression was upregulated in both CRA-sensitized mice and unsensitized mice over the course of MAV-1 infection. Despite CRA-induced differences in pulmonary inflammation, MAV-1 viral loads in lung and spleen and MAV-1 gene expression in the lung did not differ between CRA-sensitized and unsensitized mice. Our data therefore suggest that MAV-1 pathogenesis is not affected directly or indirectly by the Th2 polarization associated with allergic airway disease.
Anderson
Victoria E
VE
School of Public Health, University of Michigan, Ann Arbor, MI, USA. victoria.anderson@rmpdc.org
Nguyen
Yn
Y
Weinberg
Jason B
JB
D000256:Adenoviridae / Q000276:immunology*; D000257:Adenoviridae Infections / Q000276:immunology* / Q000473:pathology; D000818:Animals; D001249:Asthma / Q000276:immunology*; D002460:Cell Line; D005260:Female; D007371:Interferon-gamma / Q000276:immunology; D018793:Interleukin-13; D015847:Interleukin-4 / Q000276:immunology; D008168:Lung / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D012141:Respiratory Tract Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism / Q000821:virology
D018793:Interleukin-13; D015847:Interleukin-4; D007371:Interferon-gamma