Ultrastructural evidence of ependymal differentiation in a genetically proven atypical teratoid/rhabdoid tumor.
BACKGROUND
We describe a case of genetically proven atypical teratoid/rhabdoid tumor (ATRT), showing ultrastructural evidence of ependymal differentiation. Such differentiation has not been reported so far in ATRT.


CONCLUSIONS
This finding supports the concept that ATRTs as the majority of central nervous system embryonal tumors may derive from an immature and pluripotent neuroectodermal cell capable of differentiating along multiple lineages.
Antonelli
Manila
M
Department of Experimental Medicine, University La Sapienza, Rome, Italy.
Cenacchi
Giovanna
G
Modena
Piergiorgio
P
Morra
Isabella
I
Forni
Marco
M
Giangaspero
Felice
F
D002551:Cerebral Ventricle Neoplasms / Q000235:genetics / Q000601:surgery / Q000648:ultrastructure*; D002648:Child; D003582:Cytogenetics; D004805:Ependyma / Q000601:surgery / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009154:Mutation; D018335:Rhabdoid Tumor / Q000235:genetics / Q000601:surgery / Q000648:ultrastructure*; D013724:Teratoma / Q000235:genetics / Q000601:surgery / Q000648:ultrastructure*