Edaravone, a free radical scavenger, in the treatment of idiopathic sudden sensorineural hearing loss with profound hearing loss.
OBJECTIVE
Edaravone, a free radical scavenger, is a clinical drug that is widely used to reduce neuronal damage after acute cerebral infarction in Japan since 2001. The aim of this study was to investigate whether edaravone could improve treatment result in idiopathic sudden sensorineural hearing loss (ISSHL) patients with severe hearing loss.


METHODS
Between 2004 and 2006, 14 patients of ISSHL with the mean hearing levels equal or over 90dB at the initial visit were treated with edaravone. 14 counterpart control patients were selected from 45 patients who had similar prognostic factors and were treated with hyperbaric oxygenation therapy (HBO) in the past decade.


RESULTS
There were no significant differences between edaravone group and the control group in hearing recovery.


CONCLUSIONS
We considered that edaravone was not able to bring remarkable effect compared with conventional treatment regimen for ISSHL.
Sano
Hajime
H
Department of Otolaryngology, Kitasato University, School of Medicine, 1-15-1 Kitasato Sagamihara, Kanagawa 228-8555, Japan. sanohj@med.kitasato-u.ac.jp
Kamijo
Takahiro
T
Ino
Takeshi
T
Okamoto
Makito
M
D000328:Adult; D000368:Aged; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001301:Audiometry, Pure-Tone; D000077553:Edaravone; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D055815:Young Adult
D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine