Multiplicity of DNA end resection machineries in chromosome break repair.
DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues (pp. 1423-1437) published in the June 15, 2009, issue of Genes & Development identified a novel mycobacterial DNA end resection protein complex, AdnAB, that harbors dual DNA motor and dual nuclease functions. Sinha and colleagues also demonstrated that the DNA end-binding protein complex Ku regulates the activity of AdnAB.
Niu
Hengyao
H
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Raynard
Steven
S
Sung
Patrick
P
D001105:Archaea / Q000235:genetics; D001419:Bacteria / Q000201:enzymology / Q000235:genetics; D001426:Bacterial Proteins / Q000378:metabolism; D019457:Chromosome Breakage; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000502:physiology*; D005057:Eukaryotic Cells / Q000378:metabolism; D043211:Exodeoxyribonuclease V / Q000378:metabolism; D005090:Exodeoxyribonucleases / Q000378:metabolism; D009161:Mycobacterium / Q000201:enzymology* / Q000235:genetics*; D011387:Prokaryotic Cells / Q000378:metabolism; D053484:RecQ Helicases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics
D001426:Bacterial Proteins; D005090:Exodeoxyribonucleases; C407424:AddAB enzyme; C070765:recJ protein, Bacteria; D043211:Exodeoxyribonuclease V; D053484:RecQ Helicases