title: Undetected factor VIII in a patient with type 3 von Willebrands disease mistaken as severe haemophilia A.
abstract: von Willebrand disease (VWD) type 3 is a rare disorder characterized by absent or <0.1 UmL(-1) of ristocetin cofactor (VWF:RCo), and a very low level of factor VIII (FVIII:C). A total absence of FVIII:C has never been reported in type 3 VWD. This case illustrates the effect of severe von Willebrand factor (VWF) deficiency on the factor VIII level.
authors: Department of Pediatric Hematology-Oncology, McMaster University, Hamilton, ON, Canada.
authors: A M
authors: AM
authors: Mullah-Ali
authors: A K
authors: AK
authors: Chan
authors: D
authors: D
authors: Lillicrap
authors: K
authors: K
authors: Decker
authors: W
authors: W
authors: Seroski
authors: K
authors: K
authors: Moffat
authors: I
authors: I
authors: Walker
authors: M K
authors: MK
authors: Pai
mesh_terms: D002944:Circumcision, Male / Q000009:adverse effects; D003951:Diagnostic Errors; D005169:Factor VIII / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D005838:Genotype; D006467:Hemophilia A / Q000175:diagnosis / Q000235:genetics*; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D019106:Postoperative Hemorrhage / Q000188:drug therapy / Q000235:genetics*; D056729:von Willebrand Disease, Type 3 / Q000097:blood* / Q000175:diagnosis / Q000235:genetics; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D006490:Hemostatics; D014841:von Willebrand Factor; D005169:Factor VIII