Increases in serum concentration of human heart-type fatty acid-binding protein following elective coronary intervention.
BACKGROUND
Heart-type fatty acid-binding protein (H-FABP) is considered a marker of myocardial necrosis but whether or not it is modified by myocardial ischemia is not clear. We sought to investigate if H-FABP serum levels increase following non-urgent coronary angioplasty.


METHODS
We studied 31 patients undergoing coronary angioplasty. Peripheral venous samples were drawn immediately before angioplasty, 1 h after the first balloon inflation and 24 h after the procedure and assayed for H-FABP.


RESULTS
Serum levels of H-FABP increased significantly at 1 h vs baseline from 2554 +/- 1268 to 3322 +/- 245 pg ml(-1) (p = 0.024). However, no differences were observed between 1 h and 24 h after angioplasty (3268 +/- 1861 vs 3322 +/- 2459 pg ml(-1), p = 0.87). Moreover, no significant difference was observed when we compared 24 h after angioplasty with the baseline (3268 +/- 1861 vs 2554 +/- 1268 pg ml(-1), p = 0.112).


CONCLUSIONS
We conclude that H-FABP significantly increases after elective coronary angioplasty at 1 h compared with baseline values; whether or not this has any prognostic significance for future events, as it occurs with troponins, needs to be studied further.
Sbarouni
Eftihia
E
Second Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece. esbarouni@yahoo.gr
Georgiadou
Panagiota
P
Sklavainas
Ioannis
I
Chaidaroglou
Antigoni
A
Panagiotakos
Demosthenes
D
Degiannis
Demitrios
D
Voudris
Vassilis
V
D000800:Angioplasty, Balloon; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000601:surgery; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins