[Relationship between polymorphisms of FCGR2B and susceptibility of children idiopathic thrombocytopenic purpura].
The aim of study was to investigate the relationship between polymorphisms of FCGR2B232 1/T oligonucleotide and the susceptibility of children with idiopathic thrombocytopenic purpura (ITP). DNA from 76 patients with ITP and 37 controls was extracted. The SNPs of FCGR2B-232 was detected by polymerase chain reaction (PCR) combined with direct sequencing. The genotype distribution and allele frequency among different groups were compared. The results showed that the genotype (I/I, I/T, T/T) of FCGR2B-232 were 55.3%, 42.1%, and 2.6% in 76 patients with ITP, while 81.1%, 18.9%, 0% in 37 controls. The allele frequencies of FCGR2B-232 in patients with ITP were 76.3% (I232) and 23.7% (T232), but 90.5% and 9.5% in controls. There were significant differences in genotype distributions between the ITP patients and controls (chi(2) = 7.45, = 0.024). The enrichment in Thr232 allele carrier was also significant among the ITP patients as compared with the controls (chi(2) = 7.18, p = 0.007, odds ratio 3.47). There were also significant differences in allele frequencies between the ITP patients and controls [chi(2) = 6.54, p = 0.011, odds ratio 2.97, 95% CI (1.25 - 7.05)]. It is concluded that the polymorphisms of FCGR2B-232 significantly correlates with the susceptibility of children suffering from ITP. The minor Thr232 allele may be a risk genetic factor to ITP children.
He
Li-Ya
LY
Department of Hematology & Oncology, Guangzhou Children's Hospital, Guangzhou, Guangdong Province, China. linhly@126.com
Huang
Yu-Jun
YJ
Lai
Dong-Bo
DB
Zhao
Ming-Bo
MB
Zhang
Wen-Ying
WY
Xu
Tao
T
Wang
Jia-Yi
JY
Shi
Jun
J
Zhao
Yu-Hong
YH
Xu
Xiu-Xian
XX
D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D011110:Polymorphism, Genetic; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*
C499173:FCGR2B protein, human; D017452:Receptors, IgG