Spontaneous regression of natural killer cell lymphoma.
Spontaneous tumour regression is extremely rare in aggressive lymphoma. A case of natural killer (NK) cell lymphoma with cutaneous manifestation showed an indolent clinical course, and the relapsed nodular lesion disappeared spontaneously without any treatment. Although only small number of T cells were present in the primary skin lesion, there was massive CD8-positive cytotoxic T cell infiltration in the relapsed lesion. This is believed to be the first report of an abscopal effect on NK cell lymphoma. Infiltration of cytotoxic T cells strongly suggests immunological attack against the lymphoma cells.
Isobe
Y
Y
Department of Hematology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Aritaka
N
N
Sasaki
M
M
Oshimi
K
K
Sugimoto
K
K
D000368:Aged; D005260:Female; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D054391:Lymphoma, Extranodal NK-T-Cell / Q000276:immunology / Q000473:pathology*; D009365:Neoplasm Regression, Spontaneous / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology