title: Right anterior temporal lobe atrophy and person-based semantic defect: a detailed case study.
abstract: We report a new case of a right temporal pole variant of frontotemporal dementia (Rtv-FTLD), MD, who presented a slowly progressive deterioration of the recognition of familiar and famous people. We thoroughly investigated MD's face processing and semantic abilities, including a neuroimaging investigation. This analysis revealed a cross-modal person-based deficit together with a more general semantic alteration. However, there was no evidence of impairment in face perception, including holistic processing, or of an abnormal pattern of brain activation in face-sensitive cortical areas. We discuss the nature of face processing in the Rtv-FTLD and the context of a person-based semantic defect.
authors: Université Catholique de Louvain (UCL), Faculté de Psychologie et des Sciences de l'Education (PSP), Unité de Cognition et Développement (CODE), Place du Cardinal Mercier, 10, B-1348 Louvain-la-Neuve, Belgium. thomas.busigny@uclouvain.be
authors: Thomas
authors: T
authors: Busigny
authors: Laurence
authors: L
authors: Robaye
authors: Laurence
authors: L
authors: Dricot
authors: Bruno
authors: B
authors: Rossion
mesh_terms: D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D018450:Disease Progression; D005145:Face; D005149:Facial Expression; D005197:Famous Persons; D005260:Female; D057180:Frontotemporal Dementia / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000473:pathology / Q000503:physiopathology*; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual; D010468:Perceptual Disorders / Q000473:pathology / Q000503:physiopathology*; D010775:Photic Stimulation; D021641:Recognition, Psychology; D012660:Semantics