Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican Americans.
OBJECTIVE
Genetic polymorphisms in the paraoxonase 2 (PON2) gene are thought to alter its activity and contribute to the development of cardiovascular and renal disease risk. The purpose of this study is to determine whether the Arg148Gly, Cys311Ser and rs12794795 polymorphisms of PON2 examined previously by others, are associated with type 2 diabetes (T2DM), and subclinical measures of cardiovascular and renal disease risk in Mexican Americans.


METHODS
Study participants (n = 848; 21 families) were genotyped for the three polymorphisms by TaqMan assay. Association between the genotypic and phenotypic data was performed by measured genotype approach as implemented in the variance component analytical tools.


RESULTS
The Arg148Gly variant was found to be monomorphic in our dataset. Of the phenotypes examined for association, the A/C variant located in intron-1 (rs12794795) exhibited statistically significant association only with diastolic blood pressure (p = 0.018) after accounting for the trait-specific covariate effects. The Cys311Ser variant failed to show statistically significant association with any of the phenotypes examined.


CONCLUSIONS
In conclusion, the variants examined at the PON2 locus in Mexican Americans do not appear to be a major contributor to T2DM, cardiovascular or renal disease risk, although they exhibited a small effect on the blood pressure values.
Thameem
Farook
F
Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex., USA. thameem@uthscsa.edu
He
Xin
X
Voruganti
V Saroja
VS
Nath
Subrata D
SD
Fanti
Paolo
P
Blangero
John
J
Maccluer
Jean W
JW
Comuzzie
Anthony G
AG
Arar
Nedal H
NH
Abboud
Hanna E
HE
D043303:Aryldialkylphosphatase / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005192:Family Health; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007674:Kidney Diseases / Q000208:ethnology / Q000235:genetics*; D017058:Mexican Americans / Q000235:genetics; D017720:Molecular Epidemiology; D010641:Phenotype; D011110:Polymorphism, Genetic
D043303:Aryldialkylphosphatase; C468411:PON2 protein, human