Physiologically based pharmacokinetic (PBPK) modeling and simulation: applications in lead optimization.
Physiologically based pharmacokinetics (PBPK) models are increasingly being used in the lead optimization (LO) process. Although there are currently few literature reports of the application of PBPK, the scope of PBPK modeling is expanding and there is a steady increase in the number of publications in this field. Recent publications covering four important areas of the application of PBPK modeling in LO have been reviewed.
Peters
Sheila Annie
SA
Discovery DMPK, Astrazeneca R&D, Mölndal, Sweden. Sheila.Peters@astrazeneca.com
Ungell
Anna-Lena
AL
Dolgos
Hugues
H
D000818:Animals; D003198:Computer Simulation; D055808:Drug Discovery / Q000379:methods*; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism; D010599:Pharmacokinetics; D010827:Physiology
D004364:Pharmaceutical Preparations