Organocatalytic highly enantio- and diastereoselective Mannich reaction of beta-ketoesters with N-Boc-aldimines.
The catalytic enantioselective Mannich reaction promoted by chiral bifunctional organocatalysts is described. The treatment of beta-ketoesters with N-Boc-aldimines under mild reaction conditions afforded the corresponding beta-amino beta-ketoesters with excellent diastereoselectivities (up to 100:0 dr) and excellent enantioselectivities (up to 99% ee).
Kang
Young Ku
YK
Department of Chemistry, Soonchunhyang University, Asan, Chungnam 336-745, Korea.
Kim
Dae Young
DY
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
D000588:Amines; D007097:Imines; D007659:Ketones; D013890:Thiourea