title: Dengue virus type 3 in Brazil: a phylogenetic perspective.
abstract: Circulation of a new dengue virus (DENV)-3 genotype was recently described in Brazil and Colombia, but the precise classification of this genotype has been controversial. Here we perform phylogenetic and nucleotide-distance analyses of the envelope gene, which support the subdivision of DENV-3 strains into five distinct genotypes (GI to GV) and confirm the classification of the new South American genotype as GV. The extremely low genetic distances between Brazilian GV strains and the prototype Philippines/L11423 GV strain isolated in 1956 raise important questions regarding the origin of GV in South America.
authors: Laboratório de Flavivirus, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil. joselio@ioc.fiocruz.br
authors: Josélio Maria Galvão de
authors: JM
authors: Araújo
authors: Gonzalo
authors: G
authors: Bello
authors: Hermann Gonçalves
authors: HG
authors: Schatzmayr
authors: Flávia Barreto dos
authors: FB
authors: Santos
authors: Rita Maria Ribeiro
authors: RM
authors: Nogueira
mesh_terms: D001938:Brazil; D003716:Dengue Virus / Q000145:classification / Q000235:genetics*; D005838:Genotype; D006801:Humans; D009711:Nucleotides / Q000235:genetics; D010802:Phylogeny; D014759:Viral Envelope Proteins / Q000235:genetics
chemical_list: D009711:Nucleotides; D014759:Viral Envelope Proteins