Therapeutic efficacy of topical hydrocortisone aceponate in experimental flea-allergy dermatitis in dogs.
OBJECTIVE
To evaluate the treatment efficacy of a topical spray containing hydrocortisone aceponate (HCA) on dogs with flea-allergy dermatitis (FAD).


METHODS
A controlled clinical study was conducted on dogs with experimentally induced FAD. Sixteen laboratory beagles with mild to moderate clinical signs were divided into two groups. The test group received HCA by topical spray once daily for 7 days, while the control group did not. Pruritic events (time and frequency) were videotaped and then scored. Clinical signs (erythema, papules, excoriation and alopecia) present on four anatomical regions were monitored and their severity directly assessed.


RESULTS
After 2 days, pruritus was reduced by 94% in the treatment group and by 24% in the control group (P = 0.014) in cumulative time, and by 86% versus 34% (P = 0.034) in frequency. The HCA spray also resulted in significant improvements in overall clinical signs: 23% versus 0% in the control group (P = 0.0006) on day 3 and 43% versus 15% in the control group (P = 0.0006) on day 7. During the 7-day trial, no drug-related adverse effects were observed.


CONCLUSIONS
Topical treatment with HCA showed a rapid and potent antipruritic effect on dogs with FAD. HCA also demonstrated significant overall therapeutic effects on FAD-associated skin lesions.
Bonneau
S
S
R&D Department, Virbac, 13th Avenue LID, 06511 Carros, France.
Skowronski
V
V
Sanquer
A
A
Maynard
L
L
Eun
H M
HM
D000287:Administration, Topical; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000276:immunology*; D004285:Dogs; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D011537:Pruritus / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D005423:Siphonaptera / Q000276:immunology*; D014743:Videotape Recording
D005938:Glucocorticoids; C063919:hydrocortisone aceponate; D006854:Hydrocortisone