title: Attenuated prefrontal activation during a verbal fluency task in remitted major depression.
abstract: The aim of the present study was to investigate whether a functional abnormality in the left prefrontal cortex observed in patients with major depression performing a verbal fluency task is present after remission of depression. Functional magnetic resonance imaging was used to study changes in cerebral blood oxygenation in eight remitted patients with major depression and 10 healthy control subjects during a verbal fluency task. Compared to the control subjects, the patients had a reduced response in the left prefrontal cortex (middle frontal gyrus, Brodmann area 10). These findings suggest the presence of dysfunction in the left prefrontal cortex during remission in major depression.
authors: Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. goookada@hiroshima-u.ac.jp
authors: Go
authors: G
authors: Okada
authors: Yasumasa
authors: Y
authors: Okamoto
authors: Hidehisa
authors: H
authors: Yamashita
authors: Kazutaka
authors: K
authors: Ueda
authors: Hiroshi
authors: H
authors: Takami
authors: Shigeto
authors: S
authors: Yamawaki
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000378:metabolism* / Q000523:psychology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000378:metabolism*; D011597:Psychomotor Performance / Q000502:physiology; D014705:Verbal Behavior / Q000502:physiology