Store overload-induced Ca2+ release as a triggering mechanism for CPVT and MH episodes caused by mutations in RYR and CASQ genes.
MacLennan
David H
DH
Banting and Best Department of Medical Research, University of Toronto, C. H. Best Institute, Ontario, Canada. david.maclennan@utoronto.ca
Chen
S R Wayne
SR
D000818:Animals; D020013:Calcium Signaling; D002155:Calsequestrin / Q000235:genetics*; D006801:Humans; D008305:Malignant Hyperthermia / Q000235:genetics* / Q000503:physiopathology; D051379:Mice; D008954:Models, Biological; D009154:Mutation; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics*; D017180:Tachycardia, Ventricular / Q000235:genetics* / Q000503:physiopathology
D002155:Calsequestrin; D019837:Ryanodine Receptor Calcium Release Channel