Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives.
Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.
Chir
Jiun-Ly
JL
Biotechnology Center in Southern Taiwan, Academia Sinica, 2F., No. 22, Lane 31, Sec. 1, Huandong Rd., Sinshih Township, Tainan County 744, Taiwan.
Wu
Pey-Jiuann
PJ
Zou
Wei
W
Bhasin
Milan
M
Juang
Wei-Fu
WF
Guo
Chao-Qi
CQ
Wu
An-Tai
AT
D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004987:Ethers / Q000737:chemistry*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D050111:Imino Sugars / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; D004987:Ethers; D050111:Imino Sugars; D006026:Glycoside Hydrolases