title: Neuropsychological sequelae and quality of life following treatment of posterior fossa ependymomas in children.
abstract: BACKGROUND
  Modern treatment of posterior fossa ependymomas in children has improved the overall survival, but as more children live longer, the neuropsychological problems that they endure as result of the disease and its treatment become more the focus of attention.
  
  
  METHODS
  Early problems such as cerebellar mutism appear to be related to surgery and do not seem to be influenced in their incidence or outcome by the otherwise beneficial effect of oncological treatment. Indeed, the cause of cerebellar mutism is still elusive. While it was originally believed to be totally reversible, it is increasingly realized that it may be related to more complex delayed neuropsychological problems. Late problems such as the cerebellar cognitive affective syndrome are increasingly being recognized. The deleterious effect of both surgery and radiotherapy that is commonly administered afterwards is now well appreciated.
  
  
  CONCLUSIONS
  Careful neuropsychological assessment of these children and early intervention will maximize chances for recovery and improvement of academic functions and quality of life issues.
authors: Pediatric Neurosurgery, Attikon University Hospital, Rimini 1, Chaidari, Athens, 124 62, Greece.
authors: Constantinos
authors: C
authors: Charalambides
authors: Argyris
authors: A
authors: Dinopoulos
authors: Spyros
authors: S
authors: Sgouros
mesh_terms: D002526:Cerebellar Diseases / Q000209:etiology; D002648:Child; D003072:Cognition Disorders / Q000209:etiology; D004806:Ependymoma / Q000523:psychology* / Q000628:therapy*; D006801:Humans; D015192:Infratentorial Neoplasms / Q000523:psychology* / Q000628:therapy*; D001523:Mental Disorders / Q000209:etiology*; D009155:Mutism / Q000209:etiology; D011788:Quality of Life