title: Characterization of Cervidpoxvirus isolates from Oregon, California, and eastern Canada.
abstract: The present report describes the analysis of 4 Deerpox virus isolates from California, Oregon, and Ontario, Canada. All 4 isolates were associated with cutaneous crusting lesions. Examination of selected samples by electron microscopy demonstrated that the viruses were morphologically similar to orthopoxviruses. Phylogenetic analysis of the A21 gene, which is found in all poxviruses, indicated that the 4 isolates form a lineage distinct from other members except for those belonging to the genus Cervidpoxvirus of the subfamily Chordopoxvirinae. Members of the Cervidpoxvirus lineage encode a set of genes not found in other poxviruses. These include homologs of genes encoding interleukin 1 receptor antagonists (IL-1Ra) and C-type lectin-like receptors (CTLR). In the current investigation, genes encoding homologs of IL-1Ra and CTLR were amplified from all the isolates and were found to be closely related to orthologs found in the Cervidpoxvirus genus, which further supports the inclusion of these isolates in the Cervidpoxvirus genus.
authors: Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
authors: Megan
authors: M
authors: Moerdyk-Schauwecker
authors: Kathleen
authors: K
authors: Eide
authors: Robert
authors: R
authors: Bildfell
authors: Rocky J
authors: RJ
authors: Baker
authors: Wendy
authors: W
authors: Black
authors: Daniel
authors: D
authors: Graham
authors: Kim
authors: K
authors: Thompson
authors: Graham
authors: G
authors: Crawshaw
authors: George F
authors: GF
authors: Rohrmann
authors: Ling
authors: L
authors: Jin
mesh_terms: D000818:Animals; D002140:California; D003670:Deer; D009864:Ontario; D009922:Oregon; D010802:Phylogeny; D011212:Poxviridae / Q000145:classification* / Q000235:genetics; D011213:Poxviridae Infections / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D012871:Skin Diseases / Q000473:pathology / Q000662:veterinary / Q000821:virology; D014776:Virus Cultivation