title: Nor98 scrapie identified in the United States.
abstract: A distinct strain of scrapie identified in sheep of Norway in 1998 has since been identified in numerous countries throughout Europe. The disease is known as Nor98 or Nor98-like scrapie, among other names. Distinctions between classic scrapie and Nor98 scrapie are made based on histopathology and immunodiagnostic results. There are also differences in the epidemiology, typical signalment, and likelihood of clinical signs being observed. In addition, sheep that have genotypes associated with resistance to classic scrapie are not spared from Nor98 disease. The various differences between classic and Nor98 scrapie have been consistently reported in the vast majority of cases described across Europe. The current study describes in detail the pathologic changes and diagnostic results of the first 6 cases of Nor98 scrapie disease diagnosed in sheep of the United States.
authors: USDA/APHIS/NVSL, 1800 Dayton Avenue, Ames, IA 50010, USA. Christina.M.Loiacono@aphis.usda.gov
authors: Christie M
authors: CM
authors: Loiacono
authors: Bruce V
authors: BV
authors: Thomsen
authors: S Mark
authors: SM
authors: Hall
authors: Matti
authors: M
authors: Kiupel
authors: Diane
authors: D
authors: Sutton
authors: Katherine
authors: K
authors: O'Rourke
authors: Bradd
authors: B
authors: Barr
authors: Lucy
authors: L
authors: Anthenill
authors: Delwyn
authors: D
authors: Keane
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D005260:Female; D008297:Male; D011328:Prions / Q000235:genetics*; D012608:Scrapie / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D012756:Sheep; D013194:Staining and Labeling; D014481:United States / Q000453:epidemiology
chemical_list: D011328:Prions