title: [The determination of medical reference values for tumor markers in cerebrospinal fluid].
abstract: OBJECTIVE
  To determine medical reference values for tumor markers in cerebrospinal fluid.
  
  
  METHODS
  Concentrations of CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, AFP, NSE, SCC and HCG were determined by means of double-antibody sandwich ELISA in 110 patients excluding primary tumors and meningeal carcinomatosis using Roche E170 modular immunoassay analyzer.
  
  
  RESULTS
  The determined medical reference values for tumor biomarkers in cerebrospinal fluid were as follows: CEA<0.573 microg/L, CA125<2.591 U/ml, CA15-3<2.045 U/ml, CA19-9<2.272 U/ml, CA72-4<1.252 U/ml, CYFRA21-1<1.44 ng/ml, AFP<0.968 microg/L, NSE<57.666 ng/ml, SCC<0.5 microg/L, HCG<0.769 U/L. There was no correlation between any tumor marker and age (P>0.05). Concentrations of tumor markers were not affected by gender (P>0.05).
  
  
  CONCLUSIONS
  Medical reference values for CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, AFP, NSE, SCC and HCG in cerebrospinal fluid were first determined.
authors: Department of Neurology, General Hospital of PLA, Beijing 100853, China.
authors: Qiang
authors: Q
authors: Shi
authors: Chuan-qiang
authors: CQ
authors: Pu
authors: Wei-ping
authors: WP
authors: Wu
authors: Xu-sheng
authors: XS
authors: Huang
authors: Sheng-yuan
authors: SY
authors: Yu
authors: Cheng-lin
authors: CL
authors: Tian
authors: Xiu-tang
authors: XT
authors: Cao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid* / Q000592:standards*; D018394:CA-125 Antigen / Q000134:cerebrospinal fluid; D018395:CA-19-9 Antigen / Q000134:cerebrospinal fluid; D002272:Carcinoembryonic Antigen / Q000134:cerebrospinal fluid; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen