A versatile route to the tulearin class of macrolactones: synthesis of a stereoisomer of tulearin A.
A versatile synthetic approach to the tulearin class of macrolactones has been developed and deployed to make a stereoisomer of tulearin A. The knowledge gained about structure and synthesis will expedite the assignment of the stereostructure of this new anticancer agent.
Mandel
Alexander L
AL
Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS 10 rue Vauquelin,75231 Paris Cedex 05, France.
Bellosta
Véronique
V
Curran
Dennis P
DP
Cossy
Janine
J
D016588:Anticarcinogenic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D016588:Anticarcinogenic Agents; D018942:Macrolides; C526620:tulearin