title: Acute renal failure related to oxaliplatin-induced intravascular hemolysis.
abstract: Oxaliplatin is an effective chemotherapeutic agent frequently used in the treatment of colorectal carcinoma. Rare cases of renal failure and hemolytic reactions have been reported as separate side effects of oxaliplatin. Here we present a clinical picture of immune-related intravascular hemolysis and acute tubular necrosis in a patient receiving this drug. This case suggests a mechanistic explanation of renal failure in patients treated with oxaliplatin.
authors: Department of Hematology/Oncology, Paul Brousse University Hospital, AP-HP, 12, Avenue Paul Vaillant Couturier, 94804, Villejuif, France. ayhan.ulusakarya@pbr.aphp.fr
authors: Ayhan
authors: A
authors: Ulusakarya
authors: Srimanta
authors: S
authors: Misra
authors: Mazen
authors: M
authors: Haydar
authors: Hélène
authors: H
authors: Habert
authors: Vincent
authors: V
authors: Castagne
authors: Yusuf
authors: Y
authors: Gumus
authors: Béatrice
authors: B
authors: Delmas-Marsalet
authors: David
authors: D
authors: Machover
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D000068818:Cetuximab; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D011379:Prognosis
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000068818:Cetuximab; D002955:Leucovorin; D005472:Fluorouracil