Squamomelanocytic tumor: an unusual and distinctive entity of uncertain biological potential.
We report a case of a squamomelanocytic tumor of the skin. Clinically, the lesion was felt to be a melanocytic or vascular tumor but histologically was characterized by epithelioid cells with focal squamous differentiation. Immunohistochemical staining showed that half of cells stained with MNF116 and a smaller proportion stained with S100 and Melan A. A third population did not stain with either set of antigens. The lesion has some similarities to a melanocytic matricoma but no evidence of matrical differentiation. The biological potential of this distinctive tumor is not known because so few have been reported.
Leonard
Niamh
N
Department of Pathology, Royal Liverpool University Hospital, Liverpool, United Kingdom. niamh.leonard@rlbuht.nhs.uk
Wilson
Niall
N
Calonje
J Eduardo
JE
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D055623:Keratosis, Actinic / Q000188:drug therapy; D008297:Male; D008544:Melanocytes / Q000473:pathology; D018193:Neoplasms, Complex and Mixed / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil