Cinnamic aldehyde derived probes for the active site labelling of pathogenesis associated enzymes.
Michael acceptor based natural product derived probes are selective and sensitive chemical tools for the identification and characterization of pathologically relevant enzymes in MRSA.
Pitscheider
Maximilian
M
Center for Integrated Protein Science Munich CIPSM, Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany.
Sieber
Stephan A
SA
D000171:Acrolein / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D001419:Bacteria / Q000201:enzymology* / Q000378:metabolism; D020134:Catalytic Domain; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004798:Enzymes / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D020543:Proteome / Q000378:metabolism; D013194:Staining and Labeling
D004791:Enzyme Inhibitors; D004798:Enzymes; D020543:Proteome; D000171:Acrolein; D017027:Protein Tyrosine Phosphatases; C012843:cinnamaldehyde