Elevated troponin after stroke: a systematic review.
BACKGROUND
Troponin levels are elevated in some acute stroke patients, but the clinical significance of this is unclear.


METHODS
We conducted a systematic review of studies measuring troponin within 7 days of symptom onset in acute stroke patients.


RESULTS
We identified 15 studies (2,901 patients). Overall 18.1% (95% CI 13.6-22.6) had a positive troponin level. These patients were more likely to have electrocardiogram (ECG) changes suggestive of myocardial ischemia (OR 3.0; 95% CI 1.5-6.2), and there was an independent association with death (OR 2.9; 95% CI 1.7-4.8).


CONCLUSIONS
Elevated troponin level after acute stroke is common and is associated with ECG changes suggestive of myocardial ischemia and increased risk of death.
Kerr
Gillian
G
Academic Section of Geriatric Medicine, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
Ray
Gautamananda
G
Wu
Olivia
O
Stott
David J
DJ
Langhorne
Peter
P
D000208:Acute Disease; D003643:Death; D004562:Electrocardiography; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology; D016017:Odds Ratio; D012306:Risk; D020521:Stroke / Q000097:blood* / Q000453:epidemiology / Q000401:mortality; D016896:Treatment Outcome; D014336:Troponin / Q000097:blood*; D019210:Troponin I / Q000097:blood; D020107:Troponin T / Q000097:blood
D014336:Troponin; D019210:Troponin I; D020107:Troponin T