title: New sites of action for GIRK and SK channels.
abstract: It was recently discovered that two different types of voltage-insensitive K+ channels, G protein-coupled inwardly rectifying K+ (GIRK) and small-conductance Ca2+-activated K+ (SK) channels, are located on dendritic branches, spines and shafts in the postsynaptic densities of excitatory synapses in many central neurons. Together with increases in our knowledge of how these channels are regulated through stable protein-protein interactions in multi-protein complexes, this has added another layer of complexity to our understanding of synaptic transmission and plasticity.
authors: Departamento de Ciencias Médicas, Facultad de Medicina & Centro Regional de Investigaciones Biomédicas, Universidad Castilla-La Mancha, Campus Biosanitario, C/ Almansa 14, 02006 Albacete, Spain. Rafael.Lujan@uclm.es
authors: Rafael
authors: R
authors: Luján
authors: James
authors: J
authors: Maylie
authors: John P
authors: JP
authors: Adelman
mesh_terms: D000818:Animals; D049229:Dendritic Spines / Q000378:metabolism / Q000648:ultrastructure; D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D046912:Multiprotein Complexes / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D011487:Protein Conformation; D015398:Signal Transduction / Q000502:physiology; D051640:Small-Conductance Calcium-Activated Potassium Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels; D046912:Multiprotein Complexes; D051640:Small-Conductance Calcium-Activated Potassium Channels