title: Aripiprazole-induced hiccups: a case report.
abstract: Hiccups can arise from idiopathic, psychogenic and organic causes. The use of therapeutic drugs forms one of the important causes of hiccups. Although the exact pathophysiological processes involved have not yet been established, the neurotransmitters dopamine, serotonin and gamma amino butyric aid (GABA) have been documented to play a significant role in the generation of hiccups. We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole. The possible underlying neurotransmitter mechanisms, predisposing factors and clinical implications of this rare adverse event are discussed.
authors: Central Institute of Psychiatry, Ranchi, India.
authors: Prasenjit
authors: P
authors: Ray
authors: Mohammad
authors: M
authors: Zia Ul Haq
authors: S Haque
authors: SH
authors: Nizamie
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000378:metabolism; D000068180:Aripiprazole; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D002220:Carbamazepine / Q000009:adverse effects; D015984:Causality; D004298:Dopamine / Q000502:physiology; D004347:Drug Interactions; D006207:Half-Life; D016489:Head Injuries, Closed / Q000150:complications; D006606:Hiccup / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010879:Piperazines / Q000009:adverse effects* / Q000378:metabolism; D015363:Quinolones / Q000009:adverse effects* / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000502:physiology; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000187:drug effects / Q000502:physiology
chemical_list: D018692:Antimanic Agents; D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D000068180:Aripiprazole; D004298:Dopamine