title: Induction of micronuclei in buccal mucosa on chewing a mixture of betel leaf, areca nut and tobacco.
abstract: Betel quid containing areca nut and chewing tobacco is used in many parts of India. In this study we evaluated the micronuclei (MN) in buccal mucosa of healthy individuals from southern India, who were regularly chewing a mixture of betel leaf, areca nut and tobacco. A total of 44 subjects were examined. The study population included 15 chewers, 14 chewers with smoking habit and 15 controls with the mean age of 38.57 +/- 0.54, 34.50 +/- 0.95, and 33.28 +/- 0.89 years, respectively. The mean percentage of MN was 1.90 +/- 1.03 in chewers, 2.00 +/-1.12 in chewers with smoking habits and 0.81 +/- 0.66 in controls. There was no significant difference between the mean percentages of the two experimental groups. It can be concluded that a mixture of betel leaf, areca nut, and tobacco is unsafe for oral health.
authors: Department of Biotechnology, School of Life Sciences, Karpagam University, Tamil Nadu, India. sudhasellappa@yahoo.co.in
authors: Sudha
authors: S
authors: Sellappa
authors: Mythili
authors: M
authors: Balakrishnan
authors: Sangeetha
authors: S
authors: Raman
authors: Subashini
authors: S
authors: Palanisamy
mesh_terms: D000293:Adolescent; D000328:Adult; D001114:Areca / Q000009:adverse effects*; D016022:Case-Control Studies; D006801:Humans; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D012907:Smoking / Q000009:adverse effects; D014030:Tobacco, Smokeless / Q000009:adverse effects*; D055815:Young Adult