Impact of residual renal function on plasma levels of advanced oxidation protein products and pentosidine in peritoneal dialysis patients.
BACKGROUND
Residual renal function (RRF) affects the survival rate and the development of cardiovascular disease in peritoneal dialysis (PD) patients. We evaluated the impact of RRF on oxidative and carbonyl stress in PD patients.


METHODS
Plasma advanced oxidation protein products (AOPP) and pentosidine were measured in PD patients with a urine volume of > or =300 ml/day (group A, n = 17) and <300 ml/day (group B, n = 14). AOPP and pentosidine were reevaluated after 12 months of follow-up in group A.


RESULTS
Plasma levels of AOPP and pentosidine in group A were significantly lower than those in group B. Renal creatinine clearance was inversely correlated with AOPP (p < 0.05) and pentosidine (p < 0.01). After 12 months of follow-up, no significant change was observed in AOPP and pentosidine in groups who maintained a urine volume of > or =300 ml/day, but significantly increased in groups whose urine volume decreased to less than 300 ml/day. There were significant inverse relationships between the changes in renal creatinine clearance and AOPP (p < 0.01) and pentosidine (p < 0.05).


CONCLUSIONS
Loss of RRF is associated with increased plasma AOPP and pentosidine, indicating that preservation of RRF has a beneficial effect in reducing the oxidative and carbonyl stress in PD patients.
Furuya
Ryuichi
R
Renal Division, Department of Internal Medicine, Iwata City Hospital, Iwata, Japan. r-furuya@isis.ocn.ne.jp
Kumagai
Hiromichi
H
Odamaki
Mari
M
Takahashi
Masaaki
M
Miyaki
Asumi
A
Hishida
Akira
A
D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000534:rehabilitation*; D007677:Kidney Function Tests / Q000379:methods; D008239:Lysine / Q000031:analogs & derivatives* / Q000097:blood; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010530:Peritoneal Dialysis; D017382:Reactive Oxygen Species / Q000097:blood*; D020127:Recovery of Function
D001798:Blood Proteins; D017382:Reactive Oxygen Species; D001120:Arginine; C062187:pentosidine; D008239:Lysine