title: Evaluation of tetrandrine sustained release calcium alginate gel beads in vitro and in vivo.
abstract: An approach for the preparation of tetrandrine sustained release calcium alginate gel beads was described. In vitro the release of tetrandrine from sustained release dosage forms went on a time of 12 hours which fitted non-Fickian diffusion with matrix erosion significantly. In vivo the plasma concentration of tetrandrine extended preparation given in dogs reached Cmax 2.67+/-0.69 microg/ml approximately at 5.67+/-0.58 h after oral administration. The AUC0-->24 and AUC0-->infinity were 24.64+/-6.77 mg.h/l and 29.75+/-5.30 mg.h/l, respectively. The elimination half-time was 9.6+/-2.40 h. While a favorable correlation existed between in vitro and in vivo with a correlative coefficient of 0.9798 through linear regression. An investigation on the quantitative relationship between in vitro release and in vivo absorption is a highly necessary work guided for manufacture, optimization and in vivo evaluation of sustained release dosage by means of in vitro release or dissolution tests.
authors: College of Chinese Traditional Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China. mygzhtcm@163.com
authors: Yan
authors: Y
authors: Ma
authors: Wei-Zhong
authors: WZ
authors: Li
authors: Shi-Xia
authors: SX
authors: Guan
authors: Xiao-Ping
authors: XP
authors: Lai
authors: Da-Wei
authors: DW
authors: Chen
mesh_terms: D000284:Administration, Oral; D000464:Alginates; D000818:Animals; D044182:Benzylisoquinolines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D004285:Dogs; D005782:Gels; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D012995:Solubility; D013997:Time Factors
chemical_list: D000464:Alginates; D044182:Benzylisoquinolines; D003692:Delayed-Action Preparations; D005782:Gels; D006603:Hexuronic Acids; C009438:tetrandrine; D020723:Glucuronic Acid