An estimation of the chronic rejection of kidney transplant using an eternal Weibull regression: a historical cohort study.
BACKGROUND
We estimated the chronic rejection of kidney transplant using an eternal Weibull regression.


METHODS
In this historical cohort study, we enrolled all patients with chronic renal failure who were admitted to Shahid Labbafinejad medical center (Tehran, Iran) from 1984 to 2003. Using Matlab 7.0, we considered the eternal proportion theta, as a logistic-type function of the covariates and modified the survival function. We estimated the survival function in unmodified and modified forms using Weibull distribution.


RESULTS
The chance of chronic rejection was 1.95 times higher among those who received a kidney transplant before 1996. Considering all cases who received renal transplantation after 1984, males had a chance of rejection 20% less than females. Next to the eternity, Weibull model was fitted to patients who received renal transplantation after 1996. Treatment protocol was changed after 1996 expecting fewer chronic rejections; thereafter, the eternal proportion was estimated to be 0.81. This seems quite considerable as a percentage of non-failure cases.


CONCLUSIONS
Providing a non-zero eternal proportion, the modified model would be superior over the unmodified model.
Golestan
Banafsheh
B
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Hosseini-Moghaddam
Seyed Mohammadmehdi
SM
Nafar
Mohsen
M
Rennolls
K
K
Mohammad
Kazem
K
D000328:Adult; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis