[Relationship of PAHs levels in umbilical cord blood and the PAHs exposure between the mother and the paired newborns].
OBJECTIVE
To determinate the present polycyclic aromatic hydrocarbons (PAHs) levels in cord blood in order to discuss the PAHs exposure relationships between mother and paired newborns.


METHODS
347 pregnant women joined the study and the information of the 271 paired mother-newborns were used to analysis the exposure relationship. Questionnaire and bio-samples were got during the period of October 2006 to January 2008. High-performance liquid chromatography (HPLC) was used to determine the PAHs (7 kinds) levels in cord blood and maternal blood.


RESULTS
In the 271 paired mother/newborns, several kinds of PAHs were detected in nearly all the serum of the subjects. The serum concentrations of B(k)F, B(a)P and DB(a, h) A in cord blood were significantly higher than those in paired maternal blood. In addition, the serum concentrations of B(b)F in cord blood was higher than that in maternal blood (P > 0.05).


CONCLUSIONS
There are several kinds of PAHs detected in the umbilical cord blood and the PAHs levels in cord blood is the same as or even higher than that in the maternal blood, which means that could be is very important to develop the prenatal exposure assessment.
Dong
Shaoxia
S
Institute for Environmental Health and Related Product Safety, China CDC, Beijing 100021, China. dongshx@126.com
Ding
Changming
C
Zhang
Meiyun
M
Liu
Ya
Y
D000328:Adult; D001551:Benz(a)Anthracenes / Q000097:blood; D001564:Benzo(a)pyrene / Q000032:analysis; D004785:Environmental Pollutants / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure / Q000009:adverse effects*; D008431:Maternal-Fetal Exchange; D011084:Polycyclic Aromatic Hydrocarbons / Q000097:blood*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011795:Surveys and Questionnaires; D055815:Young Adult
D001551:Benz(a)Anthracenes; D004785:Environmental Pollutants; D011084:Polycyclic Aromatic Hydrocarbons; D001564:Benzo(a)pyrene