In vivo hypoglycemic effects of phenolics from the root bark of Morus alba.
Moracin M (1), Steppogenin-4'-O-beta-D-glucosiade (2), Mullberroside A (3) were isolated from the root bark of Morus alba L. and identified by spectral evidence. Compounds 1, 2 and 3 were studied in hypoglycemic effects on alloxan-diabetic mice. The results showed that compounds 1, 2 and 3 all produced hypoglycemic effects. The compound 2 in a dose of 50 mg/kg exerted significant effect (p<0.05), 2 and 3 in a dose of 100 mg/kg exerted obviously effect (p<0.01). Meantime, the compound 1 in a dose of 100 mg/kg can make the fasting blood glucose level have decreasing tendency.
Zhang
Mi
M
Institute of Botany, Jiangsu Province & Chinese Academy of Sciences, Nanjing, PR China.
Chen
Man
M
Zhang
Han-Qing
HQ
Sun
Shi
S
Xia
Bing
B
Wu
Fei-Hua
FH
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D031625:Morus / Q000737:chemistry*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010636:Phenols; D010936:Plant Extracts