[Effect of bioactive herbal preparations on structure of the gastric mucosa during stomach ulcer developing].
The present study was designed to determine experimentally the effect of a biologically active phytocomposition (BAP) on the gastric mucosa structural components during the formation and healing of ulcer induced by a single intraperitoneal injection of epinephrine. Experiments were conducted using 160 Wistar albino male rats. The fundic mucosa was studied 2, 5 and 10 days after the beginning of the experiment. The integrative assessment of a gastric mucosa was given by means of a statistical matrix method under the condition of phytocorrection. BAP was shown to change the rates of cell renewal that resulted in the restoration of the dimensions of mucosal compartments. Administration of BAP decreased the degree of mucosal damage and increased the initial size of mucosal compartments by 14-15%, as compared to those at similar time intervals in animals receiving no BAP. The number of neck mucous cells in the fundic glands was stably increased. Administration of BAP provided high parameters of the general normalization index for an organ. These changes collectively favored faster restoration of the gastric mucosa integrity after an ulcer. BAP was shown to have a protective and stimulating effect on the organ structures.
Gaskina
T K
TK
Gorchakov
V N
VN
Mel'nikova
E V
EV
D000818:Animals; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000473:pathology / Q000517:prevention & control*; D016896:Treatment Outcome
D028321:Plant Preparations