Pd(PPh3)4-PEG 400 catalyzed protocol for the atom-efficient Stille cross-coupling reaction of organotin with aryl bromides.
Aryl bromides (4 equiv) were coupled efficiently with organotin (1 equiv) in an atom-efficient way using the tetra(triphenylphosphine)palladium/polyethylene glycol 400 (Pd(PPh3)4/PEG 400) catalytic system in the presence of sodium acetate (NaOAc) as base at 100 degrees C, providing excellent yields of the corresponding functionalized biaryls in short reaction times.
Zhou
Wen-Jun
WJ
Institute of Chemistry, Department of Chemistry, Northwest Normal University, 967 An Ning Road (E.), Lanzhou 730070, P. R. China.
Wang
Ke-Hu
KH
Wang
Jin-Xian
JX