Resolution of refractory chronic autoimmune thrombocytopenic purpura following mesenchymal stem cell transplantation: a case report.
Herein we have reported the case of a man with chronic autoimmune thrombocytopenia (AITP) refractory to conventional therapy who underwent T-cell-depleted autologous peripheral blood stem cell (PBSC) transplantation. A complete, steroid-independent, platelet remission was obtained, but unfortunately he subsequently relapsed after 3 months. Finally, we administered human adipose tissue-derived mesenchymal stem cells (AMSC) with resolution to the AITP.
Fang
B
B
Henan Tumor Hospital, Henan Institute of Haematology, Henan Medical School, Henan University, Zhengzhou, China.
Song
Y P
YP
Li
N
N
Li
J
J
Han
Q
Q
Zhao
R C
RC
D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use; D006410:Hematopoiesis; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D007262:Infusions, Intravenous; D007958:Leukocyte Count; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects*; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010976:Platelet Count; D011693:Purpura / Q000209:etiology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology*; D055815:Young Adult
D016179:Granulocyte Colony-Stimulating Factor