title: Ironing out a midlife crisis.
abstract: There is a strong correlation between age, genomic instability, and the development of cancer. Working in yeast, Veatch et al. (2009) now propose that defects in the biogenesis of iron-sulfur clusters arising as a consequence of mitochondrial dysfunction contribute to the increase in genomic instability as cells age.
authors: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. sandra.vergara@duke.edu
authors: Sandra Viviana
authors: SV
authors: Vergara
authors: Dennis J
authors: DJ
authors: Thiele
mesh_terms: D016922:Cellular Senescence; D042822:Genomic Instability; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000502:physiology*
chemical_list: D007506:Iron-Sulfur Proteins; D007501:Iron