title: Accelerated partial-breast irradiation vs conventional whole-breast radiotherapy in early breast cancer: a case-control study of disease control, cosmesis, and complications.
abstract: BACKGROUND
  Accelerated partial-breast irradiation (APBI) using various approaches is being increasingly employed for selected women with early breast cancer (EBC).
  
  
  OBJECTIVE
  To conduct a case-control study comparing disease control, cosmesis, and complications in patients with EBC undergoing APBI using multicatheter interstitial brachytherapy vs those receiving conventional whole breast radiotherapy (WBRT).
  
  
  METHODS
  Women with EBC fulfilling the American Brachytherapy Society (ABS) criteria were selected as 'cases' if treated with APBI or as 'controls' if offered WBRT during the period from May 2000 to December 2004.
  
  
  METHODS
  APBI patients were treated with high-dose-rate brachytherapy (HDR) to a dose of 34 Gy/10#/6-8 days. WBRT was delivered to the whole breast to a dose of 45 Gy/25# followed by tumor bed boost, either with electrons (15 Gy/6#) or interstitial brachytherapy (HDR 10 Gy/1#).
  
  
  RESULTS
  At the median follow-up of 43.05 months in APBI and 51.08 months in WBRT there was no difference in overall survival (OS), disease-free survival (DFS), late arm edema, and symptomatic fat necrosis between the two groups. However, APBI resulted in increase in mild breast fibrosis at the tumor bed. Telangiectasias were observed in three patients of the APBI group. The cosmetic outcome was significantly better in the APBI group as compared to the WBRT group (P = 0.003).
  
  
  CONCLUSIONS
  This study revealed equivalent locoregional and distant disease control in the two groups. APBI offered better overall cosmetic outcome, though at the cost of a slight increase in mild breast fibrosis and telangiectasias.
authors: Depatment of Radiation Oncology, Tata Memorial Hospital, Mumbai, India. drtabassum2004@yahoo.co.in
authors: Tabassum
authors: T
authors: Wadasadawala
authors: Rajiv
authors: R
authors: Sarin
authors: Ashwini
authors: A
authors: Budrukkar
authors: Rakesh
authors: R
authors: Jalali
authors: Anusheel
authors: A
authors: Munshi
authors: Rajendra
authors: R
authors: Badwe
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology / Q000517:prevention & control / Q000532:radiotherapy*; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008875:Middle Aged; D011878:Radiotherapy / Q000379:methods; D016896:Treatment Outcome