title: Biaryl polyamides as a new class of DNA quadruplex-binding ligands.
abstract: We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.
authors: Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK WC1N 1AX.
authors: Khondaker M
authors: KM
authors: Rahman
authors: Anthony P
authors: AP
authors: Reszka
authors: Mekala
authors: M
authors: Gunaratnam
authors: Shozeb M
authors: SM
authors: Haider
authors: Philip W
authors: PW
authors: Howard
authors: Keith R
authors: KR
authors: Fox
authors: Stephen
authors: S
authors: Neidle
authors: David E
authors: DE
authors: Thurston
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002942:Circular Dichroism; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009757:Nylons