title: Bis-anthracenyl isoxazolyl amides have enhanced anticancer activity.
abstract: Dimeric analogs of Anthracenyl Isoxazole Amides (AIMs) (the designation AIM is in honor of the memory of Professor Albert I. Meyers) were prepared and dimer 6 exhibited the highest efficacy to date for this class of anti-tumor compounds against the human glioma Central Nervous System cell line SNB-19.
authors: Department of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT 59812, USA.
authors: Mariusz P
authors: MP
authors: Gajewski
authors: Howard
authors: H
authors: Beall
authors: Mark
authors: M
authors: Schnieder
authors: Sarah M
authors: SM
authors: Stranahan
authors: Michael D
authors: MD
authors: Mosher
authors: Kevin C
authors: KC
authors: Rider
authors: Nicholas R
authors: NR
authors: Natale
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001932:Brain Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004247:DNA / Q000737:chemistry; D019281:Dimerization; D004354:Drug Screening Assays, Antitumor; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D008968:Molecular Conformation
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D004247:DNA