title: Application of magnetic resonance spectroscopy in the differentiation of high-grade brain neoplasm and inflammatory brain lesions.
abstract: This study aims at evaluating the application of magnetic resonance spectroscopy (MRS) in the differential diagnosis of brain tumors and inflammatory brain lesions. The examinations of 81 individuals, who performed brain MRS and were retrospectively analyzed. The patients with ages between 10 and 80 years old, were divided into two groups. Group A consisted of 42 individuals with diagnoses of cerebral toxoplasmosis and Group B was formed of 39 individuals with diagnosis of glial neoplasms. On analyzing the ROC curve, the discriminatory boundary for the Cho/Cr ratio between inflammatory lesions and tumors was 1.97 and for the NAA/Cr ratio it was 1.12. RMS is an important method useful in the distinction of inflammatory brain lesions and high-degree tumors when the Cho/Cr ratio is greater than 1.97 and the NAA/Cr ratio is less than 1.12. And so this method is important in the planning of treatment and monitoring of the therapeutic efficiency.
authors: Radiologist of the Image Department, FAMERP Medical School, São José do Rio Preto, SP, Brazil. jrl.ferraz@terra.com.br
authors: José Roberto Lopes
authors: JR
authors: Ferraz-Filho
authors: Pedro Vieira
authors: PV
authors: Santana-Netto
authors: Jose Alves
authors: JA
authors: Rocha-Filho
authors: Aline
authors: A
authors: Sgnolf
authors: Fernando
authors: F
authors: Mauad
authors: Rafael Angelo
authors: RA
authors: Sanches
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000175:diagnosis*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis*; D055815:Young Adult