Genome-wide association studies in bladder cancer: first results and potential relevance.
OBJECTIVE
The role of genetic susceptibility in the development of urinary bladder cancer is unclear, as it is in many other types of cancer. Since 2007, however, an innovative research approach (i.e. genome-wide association studies or GWASs) has led to the identification of numerous genomic loci that harbor susceptibility factors for one or more cancer sites. All GWASs have been published in high-impact journals and the strengths of the design are acknowledged by all experts, but there is criticism about the relevance of the results. Late 2008, the first GWAS in bladder cancer was published.


RESULTS
In this review, the principles of GWASs are explained, as well as their strengths and limitations. The study in bladder cancer among 4000 cases and 38,000 controls identified three new susceptibility loci at 8q24, 3q28, and 5p15 that increase the risk of bladder cancer by 22, 19, and 16%, respectively. The results of two other GWASs in bladder cancer are expected to appear this year. Joint analysis of the three studies will probably identify additional susceptibility loci.


CONCLUSIONS
The results of bladder cancer GWASs may point the way to yet unknown disease mechanisms. So far, the findings are not sufficiently discriminative for risk predictions to be used in clinical care or public health.
Kiemeney
Lambertus A
LA
Department of Epidemiology, Biostatistics and HTA, The Netherlands. b.kiemeney@ebh.umcn.nl
Grotenhuis
Anne J
AJ
Vermeulen
Sita H
SH
Wu
Xifeng
X
D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D023281:Genomics; D006801:Humans; D015810:Linkage Disequilibrium; D001749:Urinary Bladder Neoplasms / Q000235:genetics*