title: Development of a VX2 pancreatic cancer model in rabbits: a pilot study.
abstract: OBJECTIVE
  An animal model of pancreatic cancer that is large enough to permit imaging and catheterization would be desirable for interventional radiologists to develop novel therapies for pancreatic cancer. The purpose of this study was to test the hypothesis that the VX2 rabbit model of pancreatic cancer could be developed as a suitable platform to test future interventional therapies.
  
  
  METHODS
  The authors implanted and grew three pancreatic VX2 tumors per rabbit in six rabbits. Magnetic resonance (MR) imaging was performed at 2 weeks to confirm tumor growth. At 3 weeks, the authors selectively catheterized the gastroduodenal artery under guidance of x-ray digital subtraction angiography (DSA). T2-weighted anatomic imaging, diffusion-weighted MR imaging, and transcatheter intraarterial perfusion (TRIP) MR imaging were then performed. After imaging, tumors were confirmed at necropsy and histopathologically. Tumor sizes at 2 and 3 weeks were compared with a paired t test (P = .05).
  
  
  RESULTS
  VX2 pancreatic tumors were grown in all six rabbits. The difference between tumor sizes at 2 and 3 weeks (1.29 cm +/- 0.39 vs 1.91 cm +/- 0.50, respectively) was significant (P < .001). All tumors were confirmed to be located within pancreatic tissue via histopathologic analysis. DSA and TRIP MR imaging were successful in five rabbits. Diffusion-weighted and anatomic MR imaging were successful in all six rabbits.
  
  
  CONCLUSIONS
  The VX2 rabbit model of pancreatic cancer is feasible, as verified by imaging and pathologic correlation, and may be a suitable platform to test future interventional therapies.
authors: Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 North Michigan Avenue, Chicago, IL 60611, USA.
authors: Aaron C
authors: AC
authors: Eifler
authors: Robert J
authors: RJ
authors: Lewandowski
authors: Sumeet
authors: S
authors: Virmani
authors: Johnathan C
authors: JC
authors: Chung
authors: Dingxin
authors: D
authors: Wang
authors: Richard L
authors: RL
authors: Tang
authors: Barbara
authors: B
authors: Szolc-Kowalska
authors: Gayle E
authors: GE
authors: Woloschak
authors: Guang-Yu
authors: GY
authors: Yang
authors: Robert K
authors: RK
authors: Ryu
authors: Riad
authors: R
authors: Salem
authors: Andrew C
authors: AC
authors: Larson
authors: Eric
authors: E
authors: Cheon
authors: Matthew
authors: M
authors: Strouch
authors: David J
authors: DJ
authors: Bentrem
authors: Reed A
authors: RA
authors: Omary
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D006801:Humans; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D010865:Pilot Projects; D011817:Rabbits; D015641:Radiography, Interventional / Q000379:methods*