[Hormones and osteoporosis update. Vitamin D and bone].
Calcium homeostasis is maintained by parathyroid hormone and vitamin D. Mechanisms of action of these calcium-regulating hormones have been extensively examined, and the intracellular signaling pathways as well as transcriptional regulation of their target genes have been elucidated. Epidemiological studies revealed the importance of vitamin D sufficiency, and efforts have been made to implement the diagnostic criteria for vitamin D insufficiency. As a therapeutic agent, a new active vitamin D analog with anti-fracture efficacy has been developed for the treatment of osteoporosis.
Endo
Itsuro
I
Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences.
Matsumoto
Toshio
T
D000058:Accidental Falls / Q000517:prevention & control; D002118:Calcium / Q000097:blood; D015195:Drug Design; D006706:Homeostasis; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology*; D053245:RANK Ligand / Q000235:genetics / Q000502:physiology; D018167:Receptors, Calcitriol / Q000502:physiology; D047488:Retinoid X Receptors / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014158:Transcription, Genetic; D014807:Vitamin D / Q000031:analogs & derivatives / Q000502:physiology* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency
D053245:RANK Ligand; D018167:Receptors, Calcitriol; D047488:Retinoid X Receptors; D014807:Vitamin D; D002118:Calcium