title: [Effectiveness of panzytrat--modern physiological enzyme preparation in complex therapy of pancreatic exocrine secretory insufficiency in cholelithiasis].
abstract: In the article the analysis of the survey with 102 patients with gallstone disease involved, 68 of whom underwent cholecystectomy and 34 were treated conservatively, is made. The content of fecal elastase 1 in stool was estimated for diagnostics of exocrine enzyme insufficiency of pancreas by immune-enzyme analysis. It was stated that 90% of patients possess secondary exocrine insufficiency of pancreas in case of gallstone disease. It is the result of complex metabolic liver abnormalities, portal and mesenterial haemodynamics, dysbiosis of large intestine which are the components of a syndrom of maldigestion and appear during gallstone disease progressing long time before hospitalization. Cholecystectomy doesn't eliminate enzyme insufficiency of pancreas. The effectiveness of using new physiological enzymatic drug Panzytrat in a complex therapy of a syndrom of maldigestion in case of gallstone disease is shown.
authors: V A
authors: VA
authors: Petukhov
authors: A V
authors: AV
authors: Mironov
authors: Zh S
authors: ZhS
authors: Semenov
authors: F S
authors: FS
authors: Ustinov
mesh_terms: D017081:Cholecystectomy, Laparoscopic; D002769:Cholelithiasis / Q000150:complications* / Q000601:surgery; D010188:Exocrine Pancreatic Insufficiency / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D005243:Feces / Q000201:enzymology; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D010196:Pancreatic Elastase / Q000378:metabolism; D010194:Pancreatin / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D010194:Pancreatin; D010196:Pancreatic Elastase