Symposium: Update on prediction and management of OHSS. Prevention of OHSS--dopamine agonists.
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of ovulation induction, which may seriously affect the patient's health, with 0.1-2.0% of the patients developing severe forms of the syndrome. OHSS signs and symptoms are direct consequences of fluid shift from capillaries to the third space due to increased vascular permeability. The mechanisms of OHSS pathophysiology remain unknown but evidence obtained in animal models prove that vascular endothelial growth factor (VEGF) is directly involved and the inhibition of the VEGF system could prevent OHSS from occurring. Dopamine agonists impede the phosphorylation of the VEGF receptor 2 and reduce the incidence and severity of OHSS with a safe clinical profile. As far as is known, this is the first pathophysiological approach for treatment and prevention of OHSS.
Busso
Cristiano E
CE
Instituto Valenciano de Infertilidad - Valencia, Plaza de la Policía Local 3, 46015-Valencia, Spain. cbusso@ivi.es
Garcia-Velasco
Juan
J
Gomez
Raúl
R
Alvarez
Claudio
C
Simón
Carlos
C
Pellicer
Antonio
A
D000818:Animals; D004195:Disease Models, Animal; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology / Q000517:prevention & control*; D010062:Ovulation Induction / Q000009:adverse effects; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D018491:Dopamine Agonists; D042461:Vascular Endothelial Growth Factor A