Edaravone, a free radical scavenger, retards the development of amygdala kindling in rats.
This study evaluated the antiepileptogenic effects of edaravone, a newly developed radical scavenger, on the amygdala kindling rats. The afterdischarge duration (ADD), AD threshold (ADT), and seizure severity in animals were measured to study the anticonvulsant effects of edaravone (2mg/kg or 20mg/kg i.p. for 7 days) on fully kindled seizures. Furthermore, for the study of antiepileptogenesis effects of the drug (2mg/kg or 20mg/kg i.p. for 7 days), not only ADD and seizure severity during kindling but also both the pre- and post-kindling ADT were measured. Edaravone neither induces nor inhibits fully kindled seizures regardless of the dose; however high-dose edaravone (20mg/kg) retarded kindling development together with shortened ADD and elevated ADT. The present data suggest that high-dose edaravone has an antiepileptogenic drug effect for the prevention of epilepsy. However, other chronic models and clinical trials are needed to confirm the effects of edaravone on the prevention of human epilepsy.
Kamida
Tohru
T
Department of Neurosurgery, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan. kamida@med.oita-u.ac.jp
Abe
Eiji
E
Abe
Tatsuya
T
Ooba
Hiroshi
H
Fujiki
Minoru
M
Kobayashi
Hidenori
H
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D000077553:Edaravone; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000494:pharmacology* / Q000627:therapeutic use; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine