What do diffusion measurements tell us about membrane compartmentalisation? Emergence of the role of interprotein interactions.
The techniques of diffusion analysis based on optical microscopy approaches have revealed a great diversity of the dynamic organisation of cell membranes. For a long period, two frameworks have dominated the way of representing the membrane structure: the membrane skeleton fences and the lipid raft models. Progresses in the methods of data analysis have shed light on the features and consequently the possible origin of membrane domains: Inter-protein interactions play a role in confinement. Innovative developments pushing forward the spatiotemporal resolution limits are currently emerging, which are likely to provide in the future a detailed understanding of the intimate functional dynamic organisation of the cell membrane.
Destainville
Nicolas
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Institut de Pharmacologie et Biologie Structurale, UMR 5089 CNRS, Université Paul Sabatier, 205 Route de Narbonne, 31062, Toulouse, France, destain@irsamc.ups-tlse.fr.
Dumas
Fabrice
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Salomé
Laurence
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