Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent.
We have developed a novel carbon nanotube-based contrast agent for both thermoacoustic and photoacoustic tomography. In comparison to deionized water, single-walled carbon nanotubes exhibited more than twofold signal enhancement for thermoacoustic tomography at 3 GHz. In comparison to blood, they exhibited more than sixfold signal enhancement for photoacoustic tomography at 1064 nm wavelength. The large contrast enhancement of single-walled carbon nanotubes was further corroborated by tissue phantom imaging studies.
Pramanik
Manojit
M
Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, 1 Brookings Drive, St. Louis, Missouri 63130, USA. mano@biomed.wustl.edu
Swierczewska
Magdalena
M
Green
Danielle
D
Sitharaman
Balaji
B
Wang
Lihong V
LV
D000162:Acoustics; D003287:Contrast Media / Q000737:chemistry*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry*; D019047:Phantoms, Imaging; D020959:Polyethylene; D014054:Tomography / Q000379:methods*
D003287:Contrast Media; D037742:Nanotubes, Carbon; D020959:Polyethylene