Hepatosplenic gammadelta T-cell lymphoma after liver transplantation: report of the first 2 cases and review of the literature.
Hepatosplenic gammadelta T-cell lymphoma is a rare lymphoproliferative disorder originating from natural killer-like Vdelta1-lymphocytes. This subtype has been described after different types of solid organ transplants. In this article, we describe the first 2 cases after liver transplantation. Both patients had thrombocytopenia with (hepato)splenomegaly but without peripheral lymphadenopathies and sinusoidal infiltration of the liver and spleen by monomorphic gammadelta-lymphocytes on pathological examination. The clinical and pathological findings, immunophenotypical profile, prognosis, and treatment are highlighted. In order to make an early diagnosis, physicians who take care of liver transplant recipients should be aware of the characteristic features of this posttransplant lymphoproliferative disorder. Therefore, a diagnostic algorithm is proposed.
Roelandt
Philip R
PR
Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium.
Maertens
Johan
J
Vandenberghe
Peter
P
Verslype
Chris
C
Roskams
Tania
T
Aerts
Raymond
R
Nevens
Frederik
F
Dierickx
Daan
D
D000328:Adult; D000465:Algorithms; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000209:etiology* / Q000628:therapy; D008113:Liver Neoplasms / Q000209:etiology / Q000628:therapy; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008495:Medical Oncology / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D011379:Prognosis; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D013160:Splenic Neoplasms / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome
D016692:Receptors, Antigen, T-Cell, gamma-delta