title: Pancreatitis is frequent among patients with side-branch intraductal papillary mucinous neoplasia diagnosed by EUS.
abstract: BACKGROUND
  Because of greater recognition and improved imaging capabilities, intraductal papillary mucinous neoplasms (IPMNs) are being diagnosed with increasing frequency. IPMNs of the main pancreatic duct cause symptoms and lead to pancreatitis. Side-branch (SB) IPMNs are thought to cause symptoms less frequently, and their association with pancreatitis is not well defined.
  
  
  OBJECTIVE
  Our purpose was to ascertain whether an association exists between SB-IPMN and pancreatitis.
  
  
  METHODS
  Single-center, retrospective study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  A total of 305 patients underwent EUS examinations between October 2002 and October 2006 for pancreatic cystic lesions.
  
  
  METHODS
  The main outcome measure was the frequency of acute or chronic pancreatitis that was not procedurally related.
  
  
  RESULTS
  Thirty-two patients had SB-IPMNs, and 11 (34%) had pancreatitis. Three patients reported a single episode, and 8 patients reported having recurrent episodes of pancreatitis. Overall, 17 (53%) patients had symptoms possibly attributable to SB-IPMN. Female sex (73% vs 38%) and multiple pancreatic lesions (54% vs 24%) were more commonly seen in those with pancreatitis, but were not statistically significant factors. Larger cyst size or cyst fluid marker levels did not appear associated with pancreatitis occurrence. EUS-FNA demonstrated communication with the pancreatic duct in 94% and thick, mucinous fluid in 84%.
  
  
  CONCLUSIONS
  Single-center, retrospective study.
  
  
  CONCLUSIONS
  Pancreatitis was frequently associated with the presence of SB-IPMNs in our referral practice. SB-IPMNs should be considered in the differential diagnosis of patients with recurrent pancreatitis with cystic lesions seen on imaging studies. EUS-FNA was the most useful modality in helping to differentiate SB-IPMNs from other lesions.
authors: Division of Gastroenterology and Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.
authors: Daniel A
authors: DA
authors: Ringold
authors: Puneet
authors: P
authors: Shroff
authors: Sanjay K
authors: SK
authors: Sikka
authors: Lourdes
authors: L
authors: Ylagan
authors: Sreenivasa
authors: S
authors: Jonnalagadda
authors: Dayna S
authors: DS
authors: Early
authors: Steven A
authors: SA
authors: Edmundowicz
authors: Riad
authors: R
authors: Azar
mesh_terms: D000046:Academic Medical Centers; D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D021441:Carcinoma, Pancreatic Ductal / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000473:pathology; D015331:Cohort Studies; D015897:Comorbidity; D003937:Diagnosis, Differential; D019160:Endosonography; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000473:pathology; D019283:Pancreatitis, Acute Necrotizing / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D016019:Survival Analysis