[Effect of growth factors on morphogenesis of human keratinocytes in vitro].
The effect of some growth factors on morphogenetic processes in the primary culture of human epidermal keratinocytes was studied in the model of formation of tubule-like structures in collagen gel. Culturing of keratinocytes in the presence of IGF and bFGF did not induce growth of tubule-like structures, whereas EGF, KGF, and HGF promoted the growth of three-dimensional epidermal outgrowths whose shape and size varied depending on the growth factor used.
Gnedeva
K Iu
KIu
Chermnykh
E S
ES
Voroteliak
E A
EA
Vasil'ev
A V
AV
Terskikh
V V
VV
D048430:Cell Shape / Q000187:drug effects*; D048429:Cell Size / Q000187:drug effects*; D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology*
D036341:Intercellular Signaling Peptides and Proteins; D003094:Collagen