title: A genome-wide scan for the Sasang constitution in a Korean family suggests significant linkage at chromosomes 8q11.22-23 and 11q22.1-3.
abstract: OBJECTIVE
  We aim to identify the genetic loci responsible for Sasang constitution type, which is important for effective personalized treatments in traditional Korean medicine.
  
  
  METHODS
  Forty (40) individuals in a Korean family were recruited for linkage analysis and 310 unrelated individuals for association analysis to confirm the linkage result.
  
  
  METHODS
  Genome-wide linkage analysis was performed for the Korean family using the Affymetrix 500K arrays. MERLIN software was used for multipoint nonparametric linkage (NPL) analysis. The significant candidate regions in linkage analysis were also investigated with association analysis of independent 310 individuals.
  
  
  RESULTS
  Linkage analysis showed four significant peaks, 3q27.3, 8p11.21, 8q11.22-23, and 11q22.1-3, whose NPL Z scores are greater than 5.0. Among the significant loci, the 8q11.22-23 and 11q22.1-3 regions were supported by independent association analysis at the level of p < 0.05.
  
  
  CONCLUSIONS
  The 8q11.22-23 and 11q22.1-3 regions were suggested as the candidate region for significant linkage to Sasang constitution.
authors: Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, South Korea.
authors: Hong-Hee
authors: HH
authors: Won
authors: Siwoo
authors: S
authors: Lee
authors: Eunsu
authors: E
authors: Jang
authors: Ka-Kyung
authors: KK
authors: Kim
authors: Young-Kyu
authors: YK
authors: Park
authors: Young Joo
authors: YJ
authors: Kim
authors: Yong Sung
authors: YS
authors: Kim
authors: Bu-Yeo
authors: BY
authors: Kim
authors: Jong-Yeol
authors: JY
authors: Kim
authors: Jong-Won
authors: JW
authors: Kim
mesh_terms: D044466:Asian People / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D007723:Korea; D008297:Male; D055670:Medicine, Korean Traditional; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D013694:Temperament