title: Changing perspectives on the perinatal management of isolated congenital diaphragmatic hernia in Europe.
abstract: Congenital diaphragmatic hernia (CDH) should be diagnosed in the prenatal period and prompt referral to a tertiary referral center for imaging, genetic testing, and multidisciplinary counseling. Individual prediction of prognosis is based on the absence of additional anomalies, lung size, and liver herniation. In severe cases, a prenatal endotracheal balloon procedure is currently being offered at specialized centers. Fetal intervention is now also offered to milder cases within a trial, hypothesizing that this may reduce the occurrence of bronchopulmonary dysplasia in survivors. Postnatal management has been standardized by European high-volume centers for the purpose of this and other trials.
authors: Woman and Child Division, Fetal Medicine Unit, University Hospital Gasthuisberg, Leuven, Belgium. jan.deprest@uzleuven.be
authors: Jan A
authors: JA
authors: Deprest
authors: Eduardo
authors: E
authors: Gratacos
authors: Kypros
authors: K
authors: Nicolaides
authors: Elise
authors: E
authors: Done
authors: Tim
authors: T
authors: Van Mieghem
authors: Leonardo
authors: L
authors: Gucciardo
authors: Filip
authors: F
authors: Claus
authors: Anne
authors: A
authors: Debeer
authors: Karel
authors: K
authors: Allegaert
authors: Irwin
authors: I
authors: Reiss
authors: Dick
authors: D
authors: Tibboel
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods*; D005060:Europe / Q000453:epidemiology; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D006548:Hernia, Diaphragmatic / Q000175:diagnosis / Q000628:therapy; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D018743:Perinatal Care / Q000639:trends*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D015995:Prevalence