title: Distinct genotype and antigenicity among genogroup II sapoviruses.
abstract: SaV, a pathogen of acute gastroenteritis, is divided into five genogroups, GI to GV. However, the relation between SaV antigenicity and genetic clusters is not fully understood. We have recently identified two GII SaV strains, Mc10 and C12, which are grouped into the same cluster based on the polymerase but are grouped into distinct clusters based on the capsid. To evaluate the difference in antigenicity between these two strains, VLP were expressed in mammalian cells. An antigen ELISA demonstrated for the first time that strains in the same GII SaV genogroup, but within different clusters, have distinct antigenicities.
authors: Department of Virology II, National Institute of Infectious Diseases, Gakuen 4-7-1, Tokyo 208-0011, Japan. oka-t@nih.go.jp
authors: Tomoichiro
authors: T
authors: Oka
authors: Kana
authors: K
authors: Miyashita
authors: Kazuhiko
authors: K
authors: Katayama
authors: Takaji
authors: T
authors: Wakita
authors: Naokazu
authors: N
authors: Takeda
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D019556:COS Cells; D017250:Caliciviridae Infections / Q000821:virology; D002522:Chlorocebus aethiops; D004797:Enzyme-Linked Immunosorbent Assay; D005759:Gastroenteritis / Q000821:virology; D005838:Genotype; D006168:Guinea Pigs; D007106:Immune Sera / Q000276:immunology; D011817:Rabbits; D029341:Sapovirus / Q000145:classification* / Q000235:genetics* / Q000276:immunology; D014162:Transfection; D014771:Virion / Q000276:immunology* / Q000378:metabolism
chemical_list: D000956:Antigens, Viral; D007106:Immune Sera