High marks for GWAS.
Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4). These studies are notable for the high effect sizes detected and the biological plausibility of the candidate genes.
Chanock
Stephen
S
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA. chanocks@mail.nih.gov
D055106:Genome-Wide Association Study; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D019089:Stem Cell Factor / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics*
D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; C499038:SPRY4 protein, human; D019089:Stem Cell Factor