title: Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles.
abstract: We report the generation of novel glycosylated indolocarbazoles by combinatorial biosynthesis, and the identification of two novel potent and selective compounds inhibitors of JAK2 and Ikkb kinases.
authors: Department Biología Funcional & Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
authors: César
authors: C
authors: Sánchez
authors: Aaroa P
authors: AP
authors: Salas
authors: Alfredo F
authors: AF
authors: Braña
authors: Martina
authors: M
authors: Palomino
authors: Antonio
authors: A
authors: Pineda-Lucena
authors: Rodrigo J
authors: RJ
authors: Carbajo
authors: Carmen
authors: C
authors: Méndez
authors: Francisco
authors: F
authors: Moris
authors: José A
authors: JA
authors: Salas
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D005810:Multigene Family; D010957:Plasmids; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D019311:Staurosporine / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D013302:Streptomyces / Q000201:enzymology / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D026121:Indole Alkaloids; D047428:Protein Kinase Inhibitors; C089657:arcyriaflavin A; C053339:rebeccamycin; D019311:Staurosporine