title: Effects of N-acetylcysteine on regeneration following partial hepatectomy in rats with nonalcoholic fatty liver disease.
abstract: OBJECTIVE
  To investigate the effect of N-acetylcysteine on regeneration following partial hepatectomy in rats with nonalcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  N-Acetylcysteine was given to seven rats with NAFLD (group 1); physiological saline was given to seven rats with NAFLD (group 2); and physiological saline was given to seven rats with a normal liver (group 3). We performed two-thirds hepatectomy in all rats and removed the remnant liver tissue 48 h later to measure the mitotic index (MI), proliferating cell nuclear antigen, glutathione (GSH), and malondialdehyde (MDA) levels.
  
  
  RESULTS
  Mitotic index values were significantly higher in group 1 than in groups 2 and 3, and higher in group 3 than in group 2. Proliferating cell nuclear antigen values were significantly higher in group 1 than in group 2, but no significant difference was found in comparison with group 3. Glutathione values in group 1 were significantly higher than in group 2 and MDA values in group 1 were lower than in group 2. There was no significant difference between groups 1 and 3 in GSH and MDA values, in both the two-thirds hepatectomy and 48-h tissues.
  
  
  CONCLUSIONS
  N-Acetylcysteine enhanced regeneration after partial hepatectomy in rats with NAFLD. We believe that it exerted this effect through its influence on oxidative stress.
authors: Second Department of General Surgery, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors: Mehmet Ali
authors: MA
authors: Uzun
authors: Neset
authors: N
authors: Koksal
authors: Huseyin
authors: H
authors: Kadioglu
authors: Yusuf
authors: Y
authors: Gunerhan
authors: Suat
authors: S
authors: Aktas
authors: Nevra
authors: N
authors: Dursun
authors: Ahmet Ozer
authors: AO
authors: Sehirli
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005234:Fatty Liver / Q000601:surgery*; D006498:Hepatectomy; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008940:Mitotic Index; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D000111:Acetylcysteine