title: Association of obestatin with blood pressure in the third trimesters of pregnancy.
abstract: Obestatin is a recently discovered 23-amino acid peptide encoded by the same gene that encodes ghrelin. It has been reported that there is a significant negative correlation between the plasma ghrelin concentration and systemic blood pressure in patients with pregnancy-induced hypertension. We investigated the plasma concentration of obestatin in 18 non-pregnant women, 18 normal pregnant women, and 15 patients with pregnancy-induced hypertension. The plasma concentrations of obestatin in these 3 groups of women were 63.4+/-9.5pg/ml, 38.1+/-6.3pg/ml, and 46.0+/-9.3pg/ml, respectively. In non-pregnant women, there was no correlation between the plasma obestatin concentration and the mean arterial pressure. However, there was a positive correlation between the plasma obestatin concentration and the mean arterial pressure in normal pregnant women and pregnant women with pregnancy-induced hypertension. These results suggest that obestatin may have some potential role in the regulation of blood pressure in normal pregnant women and women with pregnancy-induced hypertension.
authors: Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai, China.
authors: An-jing
authors: AJ
authors: Ren
authors: Qian
authors: Q
authors: He
authors: Jing-Song
authors: JS
authors: Shi
authors: Zhi-Fu
authors: ZF
authors: Guo
authors: Xing
authors: X
authors: Zheng
authors: Li
authors: L
authors: Lin
authors: Yang-Kai
authors: YK
authors: Wang
authors: Song-Yun
authors: SY
authors: Xia
authors: Li-Li
authors: LL
authors: Sun
authors: Xin
authors: X
authors: Du
authors: Ying
authors: Y
authors: Sun
authors: Lan-Mei
authors: LM
authors: Zhang
authors: Wen-Jun
authors: WJ
authors: Yuan
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D054439:Ghrelin; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood; D036361:Peptide Hormones / Q000097:blood*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood* / Q000502:physiology*; D055815:Young Adult
chemical_list: D054439:Ghrelin; D036361:Peptide Hormones; C505799:obestatin, human