title: [A case of advanced ampullary carcinoma successfully resected after primary chemotherapy with s-1 and gemcitabine].
abstract: The patient was a 53-year-old male who was admitted on an emergency basis with obstructive jaundice. He was diagnosed as having advanced ampullary carcinoma(T4 N0 H1, Stage IV b). To reduce the degree of obstructive jaundice, a self-expandable metallic stent was placed in the area of the biliary obstruction. Immediately after relief from obstructive jaundice, combination chemotherapy of S-1 and gemcitabine was given. Subsequently, CA19-9, the tumormarker level was reduced, the metastatic liver tumor disappeared, and the size of the primary lesion was remarkably reduced. Therefore, a curative surgical resection was done. This is a very instructive case for developing effective chemotherapy options to treat biliary tract cancers involving ampullary carcinoma.
authors: Dept. of Gastroenterology, Social Insurance Chukyo Hospital, Japan.
authors: Tomoyoshi
authors: T
authors: Ohno
authors: Hiroki
authors: H
authors: Koguchi
authors: Aki
authors: A
authors: Miura
authors: Yoshito
authors: Y
authors: Tanaka
authors: Masayuki
authors: M
authors: Endo
authors: Seijiro
authors: S
authors: Matsunaga
authors: Izumi
authors: I
authors: Hasegawa
authors: Atsunaga
authors: A
authors: Kato
authors: Yasushi
authors: Y
authors: Tokuda
authors: Kenji
authors: K
authors: Sakakibara
mesh_terms: D014670:Ampulla of Vater; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D004379:Duodenal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine