title: Association of polymorphism of estrogen receptor-alpha gene with circulating levels of adiponectin in postmenopausal women with type 2 diabetes.
abstract: OBJECTIVE
  Menopause is a risk factor for cardiovascular disease (CVD) in women because of the reduction in endogenous estrogen. Recently, single nucleotide polymorphisms (SNPs) of the estrogen receptor alpha (ESR-1) gene (c.454-397T>C) associated with the prognosis of myocardial infarction in postmenopausal women were identified; however, the mechanism by which genetic variation of ESR-1 contributes to the pathogenesis of CVD is unknown. Circulating levels of adipokines and inflammatory cytokines predict CVD risk; hence, this study aimed to investigate whether ESR-1 genotypes (c.454-397T>C) might influence circulating levels of adipokines and inflammatory cytokines in postmenopausal women with type 2 diabetes.
  
  
  METHODS
  Sixty-three postmenopausal women with type 2 diabetes were recruited. Serum levels of adiponectin, resistin, interleukin-6 (IL-6), and high-sensitive C-reactive protein (hs-CRP) were determined.
  
  
  RESULTS
  The genotype of ESR-1 was closely associated with serum adiponectin, which was decreased in subjects with the T allele and was lowest in those with the T/T genotype. Multiple logistic regression analysis revealed independent contribution of the homozygote for the T allele to low serum levels of adiponectin.
  
  
  CONCLUSIONS
  The T allele of the c.454-397T>C SNP of ESR-1 is associated with low serum levels of adiponectin, which may lead to a high risk of CVD in postmenopausal women.
authors: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105-8461, Japan.
authors: Rie
authors: R
authors: Yoshihara
authors: Kazunori
authors: K
authors: Utsunomiya
authors: Atsushi
authors: A
authors: Gojo
authors: Sho
authors: S
authors: Ishizawa
authors: Yasushi
authors: Y
authors: Kanazawa
authors: Keiichiro
authors: K
authors: Matoba
authors: Kanta
authors: K
authors: Taniguchi
authors: Tamotsu
authors: T
authors: Yokota
authors: Hideaki
authors: H
authors: Kurata
authors: Jun-Ichi
authors: J
authors: Yokoyama
authors: Mitsuyoshi
authors: M
authors: Urashima
authors: Naoko
authors: N
authors: Tajima
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000483:Alleles; D002318:Cardiovascular Diseases / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D052242:Adiponectin; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha