Collagen-coated microparticles in drug delivery.
Advantages of drug-incorporated collagen particles have been described for the controlled delivery system for therapeutic actions. The attractiveness of collagen lies in its low immunogenicity and high biocompatibility. It is also recognized by the body as a natural constituent rather than a foreign body. Our research and development efforts are focused towards addressing some of the limitations of collagen, like the high viscosity of an aqueous phase, nondissolution in neutral pH buffers, thermal instability (denaturation) and biodegradability, to make it an ideal material for drug delivery with particular reference to microparticles. These limitations could be overcome by making collagen conjugates with other biomaterials or chemically modifying collagen monomer without affecting its triple helical conformation and maintaining its native properties. This article highlights collagen microparticles' present status as a carrier in drug delivery.
Sehgal
Praveen Kumar
PK
Central Leather Research Institute, Bio-products Laboratory, Adyar, Chennai-600020, India. sehgal_pk@yahoo.co.in
Srinivasan
Aishwarya
A
D000818:Animals; D003094:Collagen / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D011487:Protein Conformation; D012995:Solubility; D013696:Temperature; D014783:Viscosity
D004337:Drug Carriers; D003094:Collagen