title: Effect of inflammation in the periodontium in early old age on mortality at 21-year follow-up.
abstract: OBJECTIVE
  To analyze whether inflammatory processes in the periodontium in early old age are related to subsequent mortality during 21 years of follow-up in a nondisabled 70-year-old population.
  
  
  METHODS
  Community-based population in Copenhagen.
  
  
  METHODS
  The study was based on the Glostrup Aging Study of the 1914 population, with baseline in 1984 when the participants were 70 years old and follow-up 21 years later.
  
  
  METHODS
  Three hundred thirty-five dentate men and women participated in the clinical oral health examination.
  
  
  METHODS
  Severe periodontal inflammation was measured for all teeth present as the number of teeth with inflammation and periodontal pockets 6 mm deep or more. Mortality data were obtained from the Danish Death Register at 21-year follow-up. The Cox proportional hazards regression model was used. Covariates were measured at baseline and included number of teeth, caries, sex, education, income, hypertension, diabetes mellitus, osteoarthritis, arteriostenosis, myocardial infarction, comorbidity, fatigue, and ability to brush teeth.
  
  
  RESULTS
  The analyses showed that severe periodontal inflammation in at least three teeth at age 70 was marginally related to mortality during 21-year follow-up (crude hazard ratio (HR)=1.17, 95% confidence interval (CI)=0.91-1.78). The estimate increased slightly when adjusted for sex, income, fatigue, and smoking (adjusted HR=1.37, 95% CI=0.97-1.92). The estimates were attenuated when adjusted for the specific diseases, especially arteriostenosis and osteoarthritis.
  
  
  CONCLUSIONS
  Inflammation in the periodontium in early old age tends to be associated with mortality in older age.
authors: Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark. K.Avlund@socmed.ku.dk
authors: Kirsten
authors: K
authors: Avlund
authors: Kirsten
authors: K
authors: Schultz-Larsen
authors: Ulla
authors: U
authors: Krustrup
authors: Niels
authors: N
authors: Christiansen
authors: Poul
authors: P
authors: Holm-Pedersen
mesh_terms: D000368:Aged; D016009:Chi-Square Distribution; D004245:DMF Index; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006305:Health Status Indicators; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010518:Periodontitis / Q000401:mortality*; D010519:Periodontium / Q000473:pathology*; D016016:Proportional Hazards Models; D012307:Risk Factors