[Hormones and osteoporosis update. Androgen and bone remodeling].
Androgen is well established to exert anabolic action on skeletal system among mammalians. Since androgen is effective to induce increases in bone mass and muscle content, a tissue-specific androgen analogue is expected to benefit elder peoples. However, the molecular basis and target factors underlining its anabolic action are barely known. In this review, the bone phenotypes of ARKO mice generated by us are described.
Kato
Shigeaki
S
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
D000728:Androgens / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects; D001862:Bone Resorption / Q000517:prevention & control; D001842:Bone and Bones / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011944:Receptors, Androgen / Q000235:genetics / Q000502:physiology
D000728:Androgens; D011944:Receptors, Androgen