Cell-based regeneration of intervertebral disc defects: review and concepts.
During the last century low back pain has emerged as a widespread disease often caused by intervertebral disc degeneration (IDD). IDD is a complex problem in which a variety of causes play a role. As IDD causes high costs, corporate interest has led to a number of therapies being developed. Today, these therapies focus not only on minimizing the pain caused by this disease but also on restoring intervertebral disc function. These approaches are often biological and aim to stimulate the regeneration of the intervertebral disc by injection of activator proteins, biomaterials, different cell types or complex cell matrix composites. Genetic engineering of disc cells and in vitro tissue engineering also offer a possibility for curing IDD. This article gives an overview of these concepts.
Freimark
Denise
D
Institute of Biopharmaceutical Technology, University of Applied Sciences Giessen-Friedberg, Giessen, Germany. denise.freimark@tg.fh-giessen.de
Czermak
Peter
P
D001672:Biocompatible Materials / Q000627:therapeutic use; D049109:Cell Proliferation; D017690:Cell Transplantation; D051445:Fibrocartilage; D015316:Genetic Therapy; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D007403:Intervertebral Disc / Q000473:pathology*; D017116:Low Back Pain / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D012038:Regeneration / Q000187:drug effects / Q000502:physiology; D023822:Tissue Engineering
D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins