[Effect of lantibiotic warnerin on lipid bilayer membranes].
The effect of the lantibiotic warnerin on the ionic permeability of artificial membranes has been studied. Membranes were composed of different lipid fractions, including lipids isolated from warnerin-sensitive cells of Staphylococcus epidermidis. It was shown that warnerin selectively interacts with artificial membranes of different lipid composition, which leads, in some cases, to the formation of ionic channels. A computer model of the spatial structure of warnerin has been coustructed, which supports a high probability of the membranotropic activity of this peptide.
Borisova
M P
MP
Korobov
V P
VP
Lemkina
L M
LM
Pan'kova
N V
NV
Likhatskaia
G N
GN
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001430:Bacteriocins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002308:Cardiolipins / Q000737:chemistry; D004553:Electric Conductivity; D007473:Ion Channels / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D008563:Membrane Lipids / Q000737:chemistry; D008958:Models, Molecular; D010713:Phosphatidylcholines / Q000737:chemistry; D011487:Protein Conformation; D013210:Staphylococcus / Q000737:chemistry*; D013212:Staphylococcus epidermidis / Q000737:chemistry / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D002308:Cardiolipins; D007473:Ion Channels; D008051:Lipid Bilayers; D008563:Membrane Lipids; D010713:Phosphatidylcholines; C542625:Warnerin