title: Cushing's syndrome due to a non-adrenal ectopic adrenocorticotropin-secreting Ewing's sarcoma in a child.
abstract: Ectopic ACTH syndrome (EAS) is extremely rare in the pediatric age group. Sarcomatous tumors causing EAS are even rarer. We report a 9 year-old girl presenting with Cushing's syndrome caused by ectopic ACTH production by a Ewing's sarcoma. This case illustrates that rapid appearance of Cushingoid symptoms, absence of growth retardation and the presence of hypokalemia are suggestive clues for ectopic ACTH production as the source of Cushing's syndrome.
authors: Pediatric Endocrinology and Diabetes, Marmara University, Istanbul, Turkey. tulayguran@yahoo.com
authors: Tulay
authors: T
authors: Guran
authors: Serap
authors: S
authors: Turan
authors: Behzat
authors: B
authors: Ozkan
authors: Su Gulsun
authors: SG
authors: Berrak
authors: Cengiz
authors: C
authors: Canpolat
authors: Tolga
authors: T
authors: Dagli
authors: Funda Sirin
authors: FS
authors: Eren
authors: Abdullah
authors: A
authors: Bereket
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000150:complications*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003480:Cushing Syndrome / Q000188:drug therapy / Q000209:etiology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012186:Retroperitoneal Neoplasms / Q000150:complications / Q000188:drug therapy; D012512:Sarcoma, Ewing / Q000150:complications* / Q000188:drug therapy; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D000324:Adrenocorticotropic Hormone