Epstein-Barr virus-induced infectious mononucleosis after two separate episodes of virus-associated hemophagocytic syndrome.
A 24-year-old man, who had suffered previous two episodes of non- Epstein-Barr virus (EBV)-associated hemophagocytic syndrome (HPS) at the ages of 16 and 18, developed EBV-induced infectious mononucleosis. His antibody pattern to EBV highlighted the initial infection. The disease took a self-limited course without developing into HPS. No reactivation of EBV infection was noted over the following 6 years. The patient may have attained immune competency in adulthood, which was somehow impaired during his adolescence.
Ohno
Tatsuharu
T
Division of Hematology and Immunology, Department of Internal Medicine, Ohtsu Red Cross Hospital, Shiga. tatsohno@otsu.jrc.or.jp
Ueda
Yo
Y
Kishimoto
Wataru
W
Arimoto-Miyamoto
Kazue
K
Takeoka
Tomoharu
T
Tsuji
Masaaki
M
D000914:Antibodies, Viral / Q000097:blood; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000209:etiology / Q000276:immunology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000209:etiology / Q000276:immunology; D008297:Male; D013997:Time Factors; D055815:Young Adult
D000914:Antibodies, Viral