title: Principles of neural ensemble physiology underlying the operation of brain-machine interfaces.
abstract: Research on brain-machine interfaces has been ongoing for at least a decade. During this period, simultaneous recordings of the extracellular electrical activity of hundreds of individual neurons have been used for direct, real-time control of various artificial devices. Brain-machine interfaces have also added greatly to our knowledge of the fundamental physiological principles governing the operation of large neural ensembles. Further understanding of these principles is likely to have a key role in the future development of neuroprosthetics for restoring mobility in severely paralysed patients.
authors: Duke University Center for Neuroengineering and the Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA. nicoleli@neuro.duke.edu
authors: Miguel A L
authors: MA
authors: Nicolelis
authors: Mikhail A
authors: MA
authors: Lebedev
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000166:cytology / Q000502:physiology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D006801:Humans; D009043:Motor Activity / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D010243:Paralysis / Q000628:therapy; D019736:Prostheses and Implants; D014584:User-Computer Interface