title: Mumps: not an innocent bystander in solid organ transplantation.
abstract: Recently two major outbreaks of mumps have occurred: in the UK more than 56,000 cases were notified between 2004 and 2005, and in the United States, 6,584 cases were reported in 2006. Most patients were young healthy adults, in whom mumps normally has a benign course. Little is known about mumps in the immunocompromised patient. Here, we report a case of a 56-year renal transplant recipient who developed acute irreversible transplant failure due to interstitial nephritis caused by mumps. RNA of the mumps virus was detected in the urine as well as in a renal biopsy. In view of the ongoing presence of the mumps virus in the population, one should be aware of the possible occurrence of this infection in immunocompromised patients.
authors: Renal Transplant Unit, Department of Nephrology, Division of Internal Medicine, Academic Medical Center, Amsterdam.
authors: M C
authors: MC
authors: Baas
authors: K A M I
authors: KA
authors: van Donselaar
authors: S
authors: S
authors: Florquin
authors: R S
authors: RS
authors: van Binnendijk
authors: I J M
authors: IJ
authors: ten Berge
authors: F J
authors: FJ
authors: Bemelman
mesh_terms: D001706:Biopsy; D006084:Graft Rejection; D006801:Humans; D016867:Immunocompromised Host; D007668:Kidney / Q000821:virology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009107:Mumps / Q000150:complications / Q000209:etiology*; D009395:Nephritis, Interstitial / Q000209:etiology; D011183:Postoperative Complications; D012367:RNA, Viral / Q000378:metabolism
chemical_list: D012367:RNA, Viral