Stem cells for cardiac regeneration by cell therapy and myocardial tissue engineering.
Congestive heart failure, which often occurs progressively following a myocardial infarction, is characterized by impaired myocardial perfusion, ventricular dilatation, and cardiac dysfunction. Novel treatments are required to reverse these effects - especially in older patients whose endogenous regenerative responses to currently available therapies are limited by age. This review explores the current state of research for two related approaches to cardiac regeneration: cell therapy and tissue engineering. First, to evaluate cell therapy, we review the effectiveness of various cell types for their ability to limit ventricular dilatation and promote functional recovery following implantation into a damaged heart. Next, to assess tissue engineering, we discuss the characteristics of several biomaterials for their potential to physically support the infarcted myocardium and promote implanted cell survival following cardiac injury. Finally, looking ahead, we present recent findings suggesting that hybrid constructs combining a biomaterial with stem and supporting cells may be the most effective approaches to cardiac regeneration.
Wu
Jun
J
Division of Cardiovascular Surgery, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada.
Zeng
Faquan
F
Weisel
Richard D
RD
Li
Ren-Ke
RK
D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology / Q000637:transplantation; D001672:Biocompatible Materials / Q000737:chemistry; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000502:physiology / Q000637:transplantation; D006333:Heart Failure / Q000473:pathology / Q000628:therapy*; D006801:Humans; D020100:Hydrogels; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D009206:Myocardium / Q000473:pathology*; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods; D019737:Transplants / Q000502:physiology*; D020257:Ventricular Remodeling
D001672:Biocompatible Materials; D020100:Hydrogels