title: Defining genes: a computational framework.
abstract: The precise elucidation of the gene concept has become the subject of intense discussion in light of results from several, large high-throughput surveys of transcriptomes and proteomes. In previous work, we proposed an approach for constructing gene concepts that combines genomic heritability with elements of function. Here, we introduce a definition of the gene within a computational framework of cellular interactions. The definition seeks to satisfy the practical requirements imposed by annotation, capture logical aspects of regulation, and encompass the evolutionary property of homology.
authors: Bioinformatics Group, Department of Computer Science, Interdisciplinary Center for Bioinformatics, University of Leipzig, Härtelstrasse 16-18, 04107 Leipzig, Germany. studla@bioinf.uni-leipzig.de
authors: Peter F
authors: PF
authors: Stadler
authors: Sonja J
authors: SJ
authors: Prohaska
authors: Christian V
authors: CV
authors: Forst
authors: David C
authors: DC
authors: Krakauer
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003201:Computers; D004247:DNA / Q000235:genetics; D020869:Gene Expression Profiling; D005796:Genes; D016678:Genome; D023281:Genomics; D040941:Heredity; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D010802:Phylogeny; D020543:Proteome; D012984:Software
chemical_list: D020543:Proteome; D004247:DNA