title: Human neocortical electrical activity recorded on nonpenetrating microwire arrays: applicability for neuroprostheses.
abstract: OBJECTIVE
  The goal of this study was to determine whether a nonpenetrating, high-density microwire array could provide sufficient information to serve as the interface for decoding motor cortical signals.
  
  
  METHODS
  Arrays of nonpenetrating microwires were implanted over the human motor cortex in 2 patients. The patients performed directed stereotypical reaching movements in 2 directions. The resulting data were used to determine whether the reach direction could be distinguished through a frequency power analysis.
  
  
  RESULTS
  Correlation analysis revealed decreasing signal correlation with distance. The gamma-band power during motor planning allowed binary classification of gross directionality in the reaching movements. The degree of power change was correlated to the underlying gyral pattern.
  
  
  CONCLUSIONS
  The nonpenetrating microwire platform showed good potential for allowing differentiated signals to be recorded with high spatial fidelity without cortical penetration.
authors: Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah, USA.
authors: Spencer S
authors: SS
authors: Kellis
authors: Paul A
authors: PA
authors: House
authors: Kyle E
authors: KE
authors: Thomson
authors: Richard
authors: R
authors: Brown
authors: Bradley
authors: B
authors: Greger
mesh_terms: D000200:Action Potentials; D001132:Arm / Q000502:physiology; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods*; D004594:Electrophysiology; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology; D005385:Fingers / Q000502:physiology; D006801:Humans; D008297:Male; D008839:Microelectrodes; D009043:Motor Activity / Q000502:physiology; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D019579:Neocortex / Q000502:physiology; D019736:Prostheses and Implants; D013647:Task Performance and Analysis; D014584:User-Computer Interface