Hemostatic and hemorrhagic problems in neurosurgical patients.
BACKGROUND
Abnormalities of the hemostasis can lead to hemorrhage, and on the other hand to thrombosis. Intracranial neoplasms, complex surgical procedures, and head injury have a specific impact on coagulation and fibrinolysis. Moreover, the number of neurosurgical patients on medication (which interferes with platelet function and/or the coagulation systems) has increased over the past years.


METHODS
The objective of this review is to recall common hemostatic disorders in neurosurgical patients on the basis of the "new concept of hemostasis". Therefore the pertinent literature was searched to provide a structured and up to date manuscript about hemostasis in Neurosurgery.


RESULTS
According to recent scientific publications abnormalities of the coagulation system are discussed. Pathophysiological background and the rational for specific (cost)-effective perioperative hemostatic therapy is provided.


CONCLUSIONS
Perturbations of hemostasis can be multifactorial and maybe encountered in the daily practice of neurosurgery. Early diagnosis and specific treatment is the prerequisite for successful treatment and good patients outcome.
Gerlach
Ruediger
R
Department of Neurosurgery, Johann Wolfgang Goethe University, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany. r.gerlach@em.uni-frankfurt.de
Krause
Manuela
M
Seifert
Volker
V
Goerlinger
Klaus
K
D000465:Algorithms; D001777:Blood Coagulation / Q000502:physiology*; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D002985:Clinical Protocols; D003029:Coagulants / Q000494:pharmacology / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006470:Hemorrhage / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D006487:Hemostasis / Q000502:physiology*; D006488:Hemostasis, Surgical / Q000379:methods; D006801:Humans; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control
D003029:Coagulants; D005343:Fibrinolytic Agents