Nanostructured silica materials as drug-delivery systems for Doxorubicin: single molecule and cellular studies.
We apply mesoporous thin silica films with nanometer-sized pores as drug carriers and incorporate the widely used anticancer drug Doxorubicin. Through single-molecule based measurements, we gain mechanistic insights into the drug diffusion inside the mesoporous film, which governs the drug-delivery at the target-site. Drug dynamics inside the nanopores is controlled by pore size and surface modification. The release kinetics is determined and live-cell measurements prove the applicability of the system for drug-delivery. This study demonstrates that mesoporous silica nanomaterials can provide solutions for current challenges in nanomedicine.
Lebold
Timo
T
Department of Chemistry and Biochemistry, Center for Nanoscience (CeNS) and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universitat Munchen, 81377 Munich, Germany.
Jung
Christophe
C
Michaelis
Jens
J
Bräuchle
Christoph
C
D000970:Antineoplastic Agents / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide; D013501:Surface-Active Agents / Q000737:chemistry
D000970:Antineoplastic Agents; D004337:Drug Carriers; D013501:Surface-Active Agents; D012822:Silicon Dioxide; D004317:Doxorubicin