Ionic liquids as superior solvents for headspace gas chromatography of residual solvents with very low vapor pressure, relevant for pharmaceutical final dosage forms.
1-n-Butyl-3-methylimidazolium dimethyl phosphate (BMIM DMP) was identified as the most suitable ionic liquid as solvent for the headspace gas chromatographic analysis of solvents with very low vapor pressure such as dimethylsulfoxide, N-methylpyrrolidone, sulfolane, tetralin, and ethylene glycol in a realistic matrix of commonly used excipients (carboxymethylcellulose, magnesium stearate, guar flour, and corn starch) in pharmaceutical products. Limits of quantification and limits of detection were in the low microgram per gram range. The detection of traces of sulfolane in a real sample of tablets containing the drug cefpodoxim proxetil demonstrated the applicability of the method.
Laus
Gerhard
G
Faculty of Chemistry and Pharmacy, University of Innsbruck, Innrain 52a, 6020 Innsbruck, Austria.
Andre
Max
M
Bentivoglio
Gino
G
Schottenberger
Herwig
H
D015296:Ceftizoxime / Q000031:analogs & derivatives / Q000737:chemistry; D005079:Excipients / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D007093:Imidazoles / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012997:Solvents / Q000032:analysis*; D013876:Thiophenes / Q000737:chemistry; D055548:Vapor Pressure; D000097627:Cefpodoxime Proxetil
D015296:Ceftizoxime; D005079:Excipients; D007093:Imidazoles; D052578:Ionic Liquids; D009943:Organophosphorus Compounds; D004364:Pharmaceutical Preparations; D012997:Solvents; D013876:Thiophenes; D000097627:Cefpodoxime Proxetil; C525963:1-butyl-3-methylimidazolium; C007477:dimethyl phosphate; C013693:sulfolane