title: 11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness.
abstract: BACKGROUND
  To determine the usefulness of positron emission tomography (PET) with (11)C-acetate (AC) for imaging lung adenocarcinoma and evaluating its tumor aggressiveness, AC- and (18)F-fluorodeoxyglucose (FDG)-PET were compared.
  
  
  METHODS
  One hundred and sixty-nine adenocarcinomas with clinical stage IA and 53 benign nodules were examined by both AC- and FDG-PET before surgery. The sensitivity and specificity for discriminating benign/adenocarcinoma were compared between AC- and FDG-PET. The AC and FDG uptakes were examined to determine the relationship with tumor aggressiveness, i.e., pathological tumor stage, lymphatic, vascular, or pleural involvement, and proliferative activity determined by Ki-67 staining score.
  
  
  RESULTS
  While the sensitivity of AC-PET was significantly higher than FDG-PET for bronchioloalveolar carcinoma (BAC) and well-differentiated (W/D) adenocarcinoma (p < 0.001 and 0.006, respectively), there was no significant difference for moderately or poorly differentiated adenocarcinoma. The specificity was not different between them. While FDG uptakes were significantly higher in tumors with pathological advanced stages or those with lymphatic, vascular and/or pleural involvements than in tumors with pathological stage IA or those without these tumor involvements (p = 0.04 to p < 0.001), AC uptake did not show significant differences between the respective sub-groups except according to the tumor stage. While both AC and FDG uptakes showed a significant correlation with Ki-67 staining scores (p = 0.03 and p < 0.001, respectively), the correlation coefficient of former was lower than that of latter (p = 0.07).
  
  
  CONCLUSIONS
  While AC-PET can image BAC and W/D adenocarcinoma with a higher sensitivity than FDG-PET, it cannot evaluate tumor aggressiveness of clinical stage IA lung adenocarcinoma as well as FDG-PET.
authors: Department of Thoracic Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
authors: Hidekatsu
authors: H
authors: Shibata
authors: Hiroaki
authors: H
authors: Nomori
authors: Kimiichi
authors: K
authors: Uno
authors: Ken-Ichi
authors: K
authors: Iyama
authors: Katsumi
authors: K
authors: Tomiyoshi
authors: Rumi
authors: R
authors: Nakashima
authors: Kazuya
authors: K
authors: Sakaguchi
authors: Tomoyuki
authors: T
authors: Goya
authors: Iwao
authors: I
authors: Takanami
authors: Kiyoshi
authors: K
authors: Koizumi
authors: Takashi
authors: T
authors: Suzuki
authors: Masahiro
authors: M
authors: Kaji
authors: Hirotoshi
authors: H
authors: Horio
mesh_terms: D000085:Acetates / Q000378:metabolism; D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D002244:Carbon / Q000378:metabolism; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D012372:ROC Curve; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D000085:Acetates; C438206:carbon-11 acetate; D019788:Fluorodeoxyglucose F18; D002244:Carbon