title: SKP-ing TAp63: stem cell depletion, senescence, and premature aging.
abstract: The p53 family member p63 comprises multiple isoforms and is critical for stratified epithelial development. In this issue of Cell Stem Cell, by generating isoform-specific knockout mice, Su et al. (2009) reveal pivotal roles for TAp63 in the maintenance of dermal and epidermal precursors, genomic stability, and organismal longevity.
authors: Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors: Veronica G
authors: VG
authors: Beaudry
authors: Laura D
authors: LD
authors: Attardi
mesh_terms: D019588:Aging, Premature / Q000209:etiology* / Q000235:genetics; D000818:Animals; D016922:Cellular Senescence / Q000235:genetics; D051379:Mice; D010750:Phosphoproteins / Q000235:genetics / Q000502:physiology*; D012867:Skin / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*
chemical_list: D010750:Phosphoproteins; D015534:Trans-Activators; C486419:Trp63 protein, mouse