title: Cytotoxic bisnor- and norditerpene dilactones having 7alpha,8alpha-epoxy-9,11-enolide substructure from Podocarpus macrophyllus D. DON.
abstract: Fourteen new bisnor- and norditerpene dilactones, makilactones E-R, having a 7alpha : 8alpha-epoxy-9,11-enolide substructure, were isolated from a methanolic extract of the root and the bark of Podocarpus macrophyllus D. DON (Podocarpaceae) with thirteen known bisnor- and norditerpenoids, and the structures of those new bisnor- and norditerpenoids were determined on the basis of their spectroscopic studies. Of the thirteen known ones isolated, the structures of two, i.e., podolactone B and inumakilactone B, were revised on the basis of X-ray crystallographic analysis and spectroscopic analysis. Many of the compounds of this type isolated in this study showed potent cytotoxic activities against P388 murine leukemia cells.
authors: School of Pharmacy, Tokyo University of Pharmacy & Life Science.
authors: Kimihiko
authors: K
authors: Sato
authors: Yasunori
authors: Y
authors: Inaba
authors: Hyun-Sun
authors: HS
authors: Park
authors: Toshiyuki
authors: T
authors: Akiyama
authors: Tetsuo
authors: T
authors: Koyama
authors: Haruhiko
authors: H
authors: Fukaya
authors: Yutaka
authors: Y
authors: Aoyagi
authors: Koichi
authors: K
authors: Takeya
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008958:Models, Molecular; D008967:Molecular Biology; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*; D064028:Tracheophyta / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes