Physicochemical characterization of tacrolimus-loaded solid dispersion with sodium carboxylmethyl cellulose and sodium lauryl sulfate.
To develop a novel tacrolimus-loaded solid dispersion with improved solubility, various solid dispersions were prepared with various ratios of water, sodium lauryl sulfate, citric acid and carboxylmethylcellulose-Na using spray drying technique. The physicochemical properties of solid dispersions were investigated using scanning electron microscopy, differential scanning calorimetery and powder X-ray diffraction. Furthermore, their solubility and dissolution were evaluated compared to drug powder. The solid dispersion at the tacrolimus/CMC-Na/sodium lauryl sulfate/citric acid ratio of 3/24/3/0.2 significantly improved the drug solubility and dissolution compared to powder. The scanning electron microscopy result suggested that carriers might be attached to the surface of drug in this solid dispersion. Unlike traditional solid dispersion systems, the crystal form of drug in this solid dispersion could not be converted to amorphous form, which was confirmed by the analysis of DSC and powder X-ray diffraction. Thus, the solid dispersion system with water, sodium lauryl sulfate, citric acid and CMC-Na should be a potential candidate for delivering a poorly water-soluble tacrolimus with enhanced solubility and no convertible crystalline.
Park
Young-Joon
YJ
Research Center, Samil Pharmaceutical Co. Ltd., Ansan 712-749, Korea.
Ryu
Dong-Sung
DS
Li
Dong Xun
DX
Quan
Qi Zhe
QZ
Oh
Dong Hoon
DH
Kim
Jong Oh
JO
Seo
Youn Gee
YG
Lee
Young-Im
YI
Yong
Chul Soon
CS
Woo
Jong Soo
JS
Choi
Han-Gon
HG
D002266:Carboxymethylcellulose Sodium; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D016559:Tacrolimus / Q000737:chemistry*
D004337:Drug Carriers; D012967:Sodium Dodecyl Sulfate; D002266:Carboxymethylcellulose Sodium; D016559:Tacrolimus