Physicochemical investigation of the solid dispersion systems of etoricoxib with poloxamer 188.
Solid dispersion systems of a poorly water-soluble drug, etoricoxib were prepared with poloxamer 188 in 1:0.5, 1:1.5 and 1:2.5 ratios and evaluated by FTIR, powder XRD and dissolution studies. Physical studies demonstrated a strong hydrogen bonding with significant decrease in the crystallinity and formation of amorphous etoricoxib in its binary systems. All binary systems of etoricoxib showed faster dissolution than pure drug alone (P < 0.001). However, 1:2.5 proportion of etoricoxib: poloxamer 188 showed superior performance (DE45: 71.27% +/- 3.85) in enhancing solubility and dissolution rate of etoricoxib suggesting optimum ratio of the carrier.
Karekar
Poonam
P
Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra, India.
Vyas
Vikrant
V
Shah
Manali
M
Sancheti
Pankajkumar
P
Pore
Yogesh
Y
D002626:Chemistry, Pharmaceutical / Q000379:methods; D003460:Crystallization; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D000077613:Etoricoxib; D006860:Hydrogen Bonding; D020442:Poloxamer / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013450:Sulfones / Q000737:chemistry*; D014961:X-Ray Diffraction
D052246:Cyclooxygenase 2 Inhibitors; D004337:Drug Carriers; D011725:Pyridines; D013450:Sulfones; D020442:Poloxamer; D000077613:Etoricoxib