title: [Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin].
abstract: A water-soluble compound, sodium formononetin-3'-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of sodium formononetin-3'-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of sodium formononetin-3'-sulfonate were tested by using rat's high fat model induce by feeding with high fat food. The results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.
authors: Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, China.
authors: Qiu-ya
authors: QY
authors: Wang
authors: Qing-hua
authors: QH
authors: Meng
authors: Zun-ting
authors: ZT
authors: Zhang
authors: Zhen-jun
authors: ZJ
authors: Tian
authors: Hui
authors: H
authors: Liu
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007529:Isoflavones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D008297:Male; D015394:Molecular Structure; D020011:Protective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D007529:Isoflavones; D008055:Lipids; D020011:Protective Agents; D014280:Triglycerides; C548268:formononetin-3-sulfonate; C007768:formononetin; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase