title: Early translation of adipose-derived cell therapy for cardiovascular disease.
abstract: Over the past decade, cell therapy has emerged as a new approach to reversing myocardial ischemia. Several types of adult stem cells have been studied in both preclinical and clinical conditions for this purpose: bone marrow cells, circulating cells, and myoblasts. Nevertheless, the quest for the ideal "anti-ischemic" cell is still ongoing. Recently, the existence of a population of stem cells located in adipose tissue (adipose-derived stem cells) has been observed. These are able to differentiate into multiple cell lineages including cardiomyocytic differentiation. In this review we discuss the basic principles of adipose-derived stem cells (types and characteristics, harvesting, and expansion), the initial experimental studies, and the currently ongoing clinical trials.
authors: Cardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors: Ricardo
authors: R
authors: Sanz-Ruiz
authors: Eugenia
authors: E
authors: Fernández-Santos
authors: Marta
authors: M
authors: Domínguez-Muñoa
authors: Radoslaw
authors: R
authors: Parma
authors: Adolfo
authors: A
authors: Villa
authors: Lucía
authors: L
authors: Fernández
authors: Pedro L
authors: PL
authors: Sánchez
authors: Francisco
authors: F
authors: Fernández-Avilés
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D035843:Biomedical Research; D002318:Cardiovascular Diseases / Q000473:pathology* / Q000628:therapy*; D015510:Clinical Medicine; D006801:Humans; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology