Performance of the Epstein-Barr virus and herpes simplex virus immunoglobulin m assays on the liaison platform with sera from patients displaying acute parvovirus B19 infection.
Acute parvovirus B19 infection has been reported to cause false-positive results frequently in the Epstein-Barr (EBV) and herpes simplex virus (HSV) immunoglobulin M (IgM) assays from DiaSorin performed on the Liaison platform. We tested 65 sera from patients with a presumptive or conclusive diagnosis of acute parvovirus B19 infection in both assays and obtained no false-positive results in the EBV IgM test and 10.4% nonspecific reactivities in the HSV IgM assay. Our data support the specificity of both assays in this clinical setting.
Costa
Elisa
E
Service of Microbiology, Hospital Clínico Universitario, Valencia, Spain.
Tormo
Nuria
N
Clari
María Angeles
MA
Bravo
Dayana
D
Muñoz-Cobo
Beatriz
B
Navarro
David
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications* / Q000821:virology; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D018139:Simplexvirus / Q000276:immunology*; D055815:Young Adult
D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic