title: Comparative analysis of soft neurological signs in positive and negative subtype of schizophrenia.
abstract: BACKGROUND
  The objective of the study was to investigate neurological deficit in schizophrenia and to compare soft neurological signs in positive and negative subtypes of schizophrenia.
  
  
  METHODS
  66 patients with schizophrenia were evaluated with the Positive and Negative Syndrome Scale to classify the subtype of schizophrenia: positive subtype (36 patients) and negative subtype (30 patients), all of which were entering into remission. To examine the neurological soft signs we compared scores on the Neurological Evaluation Scale (NES) for positive and negative subtype.
  
  
  RESULTS
  The negative subtype of schizophrenia showed significantly higher neurological soft signs in comparison to the positive subtype, with reduced functioning in the sensory integration and motor coordination subscale as well as the other subscale.
  
  
  CONCLUSIONS
  The main finding in this study indicates that patients with schizophrenia have neurological impairment, and that the negative subtype has significantly higher neurological impairment than the positive subtype. The results further support the significance of the soft neurological signs as a possible marker of different subtypes of schizophrenia.
authors: Institute of Psychiatry Clinical Center of Serbia, Pasterova 2, 11000 Belgrade, Serbia. tijanacvetic@yahoo.com
authors: Tijana
authors: T
authors: Cvetić
authors: Olivera
authors: O
authors: Vuković
authors: Dubravka
authors: D
authors: Britvić
authors: Maja
authors: M
authors: Ivković
authors: Slavica
authors: S
authors: Dukić-Dejanović
authors: Dusica
authors: D
authors: Lecić-Tosevski
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000523:psychology; D009460:Neurologic Examination / Q000706:statistics & numerical data*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data*; D011594:Psychometrics; D012559:Schizophrenia / Q000145:classification / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D055815:Young Adult