alpha/beta-Arteether-induced mania in a predisposed adolescent.
Artemisinin, by the name of Qinghaosu, has been used in China for the treatment of fever over the years. Recently, a number of artemisinin derivatives such as artesunate, artemether, dihydroartemisinin, and arteether have been developed and have found widespread clinical use because of their efficacy against resistant forms of all plasmodial species and a favorable side-effect profile. However, concerns have been expressed about the neurotoxic effects of artemisinin derivatives based on some animal and human studies. We present a case of alpha/beta-arteether-induced mania in an adolescent having a family history of chloroquine-induced psychosis to discuss the hereditary predispositions, possible mechanisms, management, and clinical implications of this rare adverse event.
Haq
Mohammad Zia Ul
MZ
Centre for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi 834006, India. drziaulhaq@gmail.com
Mishra
Biswa Ranjan
BR
Goyal
Nishant
N
Sinha
Vinod Kumar
VK
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D000293:Adolescent; D000962:Antimalarials / Q000009:adverse effects* / Q000737:chemistry; D037621:Artemisinins / Q000009:adverse effects* / Q000737:chemistry; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D002626:Chemistry, Pharmaceutical; D002738:Chloroquine / Q000009:adverse effects; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007194:India; D007273:Injections, Intramuscular; D016778:Malaria, Falciparum / Q000188:drug therapy; D010375:Pedigree; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic / Q000235:genetics; D035583:Rare Diseases; D012307:Risk Factors
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000962:Antimalarials; D037621:Artemisinins; D002738:Chloroquine; C055141:artemotil