Genetic association study of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura.
The effect of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura (MA) susceptibility is not established yet. We studied the association between the MA end-diagnosis and three migraine trait components and 32 single nucleotide polymorphisms (SNPs) capturing the variation of endothelin genes in 850 Finnish migraine patients and 890 non-migrainous individuals. The SNPs showing evidence of association were further studied in 648 German migraine patients and 651 non-migrainous individuals. No significant association was detected. However, the homozygous minor genotype (5% in cases) of the EDNRA SNP rs2048894 showed nominal association with MA both in the Finnish sample (P = 0.015) and in the pooled sample [odds ratio (OR) 1.61, 95% confidence interval (CI) 1.12-2.32, P = 0.010] when adjusted for gender and sample origin. The trait age of onset < 20 years was also associated with rs2048894 (OR 1.69, 95% CI 1.13-2.54, P = 0.011) in the pooled sample. To confirm this finding studies on even larger samples are required.
Tikka-Kleemola
P
P
Institute of Molecular Medicine in Finland, University of Helsinki, 00014 Helsinki, Finland. paivi.j.tikka@helsinki.fi
Kaunisto
M A
MA
Hämäläinen
E
E
Todt
U
U
Göbel
H
H
Kaprio
J
J
Kubisch
C
C
Färkkilä
M
M
Palotie
A
A
Wessman
M
M
Kallela
M
M
D000328:Adult; D017668:Age of Onset; D019332:Endothelin-1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D020325:Migraine with Aura / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044022:Receptor, Endothelin A / Q000235:genetics*
D019332:Endothelin-1; D044022:Receptor, Endothelin A