Development and set-up of a portable device to monitor airway exhalation and deposition of particulate matter.
The aim of this study was to assess and monitor airway exhalation and deposition of particulate matter (PM). After standardizing inspiratory/expiratory flow and volumes, a novel device was tested on a group of 20 volunteers and in a field study on workers exposed to cristobalite. Both male and female subjects showed a higher percentage of deposition in the 0.5 microm channel than in the 0.3 microm channel on a laser particle counter, but it was higher in the males because of their higher exhaled lung volumes. The device was tested on a wider range of particles (0.3-0.5-1.0-2.5 microm) in the cristobalite productive division. The device has low intrasubject variability and good reproducibility, with geometric mean of %CV < 5%. Such a measure can be used to assess individual susceptibility to PM, making repeated measures in different environments, and examining the persistence of particles in the airways after a period in polluted environments.
Goldoni
Matteo
M
Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Parma, Italy.
Caglieri
Andrea
A
De Palma
Giuseppe
G
Longo
Sonia
S
Acampa
Olga
O
Poli
Diana
D
Manini
Paola
P
Apostoli
Pietro
P
Franchini
Innocente
I
Corradi
Massimo
M
Mutti
Antonio
A
D000328:Adult; D000388:Air; D004784:Environmental Monitoring / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D045853:Exhalation / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D001239:Inhalation / Q000502:physiology; D019570:Inhalation Exposure; D008297:Male; D016273:Occupational Exposure; D015203:Reproducibility of Results; D012822:Silicon Dioxide / Q000633:toxicity; D014797:Vital Capacity
D012822:Silicon Dioxide