Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses.
We measured T-cell responses to human immunodeficiency virus type 1 (HIV-1) cryptic epitopes encoded by regions of the viral genome not normally translated into viral proteins. T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects.
Garrison
Keith E
KE
Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California 94110, USA.
Champiat
Stephane
S
York
Vanessa A
VA
Agrawal
Ashish T
AT
Kallas
Esper G
EG
Martin
Jeffrey N
JN
Hecht
Frederick M
FM
Deeks
Steven G
SG
Nixon
Douglas F
DF
D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology* / Q000502:physiology; D006801:Humans; D014176:Protein Biosynthesis; D013601:T-Lymphocytes / Q000276:immunology*; D014779:Virus Replication; D054321:rev Gene Products, Human Immunodeficiency Virus / Q000276:immunology; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000276:immunology
D018984:Epitopes, T-Lymphocyte; D054321:rev Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus