Effect of mitratapide on body composition, body measurements and glucose tolerance in obese Beagles.
The objective of this study was to confirm that weight loss after treatment with mitratapide (Yarvitan®) is loss of adipose tissue. Obese dogs were treated with the recommended treatment schedule of mitratapide. Dual-energy X-ray absorptiometry (DEXA) was done before and after the treatment schedule. Body weight, feed consumption and pelvic circumference were recorded and a glucose tolerance test was performed. Dualenergy X-ray absorptiometry measurements showed an impressive loss of fat tissue, corresponding to a mean loss of approximately 41.6% of the body fat mass recorded before treatment. After treatment with mitratapide, the mean body fat percentage had returned within the normal range. At the end of the study, the dogs had lost on average 14.2% of their body weight and 15.2% of their pelvic circumference compared to baseline. The results also suggest that losing weight with mitratapide might help to reverse insulin resistance.
Dobenecker
Britta
B
Department of Veterinary Sciences, Chair of Animal Nutrition and Dietetics, Faculty of Veterinary Medicine, Ludwig-Maximilians University Munich, Schönleutnerstrasse 8, 85764 Oberschleissheim, Germany. Dobenecker@lrz.uni-muenchen.de
De Bock
Manuelle
M
Engelen
Marc
M
Goossens
Lieve
L
Scholz
Armin
A
Kienzle
Ellen
E
D015502:Absorptiometry, Photon / Q000662:veterinary; D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology / Q000627:therapeutic use; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004435:Eating / Q000187:drug effects; D005260:Female; D005951:Glucose Tolerance Test / Q000662:veterinary*; D009765:Obesity / Q000188:drug therapy / Q000662:veterinary*; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use*
D019440:Anti-Obesity Agents; D010879:Piperazines; D014230:Triazoles; C493731:mitratapide