GABA keeps up an appetite for life.
In the arcuate nucleus of the hypothalamus, neurons that produce the neuropeptides NPY and AgRP play a vital role in the maintenance of energy homeostasis. In this issue, Wu et al. (2009) show that these neurons modulate feeding behavior in mice by providing GABAergic input to the parabrachial nucleus in the brainstem.
Dietrich
Marcelo O
MO
Program on Cell and Neurobiology of Energy Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Horvath
Tamas L
TL
D000818:Animals; D001066:Appetite; D001933:Brain Stem / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D051379:Mice; D009479:Neuropeptides / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000235:genetics / Q000378:metabolism*
D009479:Neuropeptides; D005680:gamma-Aminobutyric Acid