title: Head and neck cancer in Germany: a site-specific analysis of survival of the Thuringian cancer registration database.
abstract: OBJECTIVE
  To describe epidemiology and prognosis of head and neck cancer in Germany.
  
  
  METHODS
  We analyzed the Thuringian cancer registry database from 1996 to 2005. 3,821 cases with primary head and neck cancer were evaluated for patient's characteristics, tumor stage, incidence, treatment, and trends in overall survival.
  
  
  RESULTS
  During the period 1996-2005, the incidence of oropharynx, hypopharynx, larynx, and salivary gland cancer increased significantly for males, and of oral cavity and hypopharynx cancer for females. There was a significant trend using more multimodal therapy combining surgery, radiotherapy, and chemotherapy, and to use less radiotherapy as a single modality. The median follow-up time of patients alive was 42 months. The 5-year overall survival rate (OS) for all patients was 47.8%. The site-specific 5-year OS for lip, oral cavity, nasopharynx, oropharynx, hypopharynx, larynx, salivary gland, and nose/paranasal sinus cancer was 75.7, 42.6, 43.5, 45.9, 27.2, 57.3, 61.0, and 34.9%, respectively. The multivariate analysis showed that male gender, age ≥ 60 years, therapy without surgery, higher T classification, N classification, and M classification were independent significant negative risk factors for OS (p < 0.0001). Cancer of the oral cavity and of the hypopharynx had a significant lower OS than lip cancer (p = 0.012 and p = 0.044, respectively). Comparing the periods 1996-2000 with the period 2001-2005, there was no significant improvement of OS for any subsite.
  
  
  CONCLUSIONS
  Many subsites of head and neck cancer have changing incidence. Although treatment strategies have changed, outcome has not improved significantly from 1995 to 2006.
authors: Department of Otorhinolaryngology, University Hospital, Friedrich Schiller University Jena, Lessingstrasse 2, 07740 Jena, Germany. orlando.guntinas@med.uni-jena.de
authors: Orlando
authors: O
authors: Guntinas-Lichius
authors: Thomas
authors: T
authors: Wendt
authors: Jens
authors: J
authors: Buentzel
authors: Dirk
authors: D
authors: Esser
authors: Peter
authors: P
authors: Lochner
authors: Andreas
authors: A
authors: Mueller
authors: Stefan
authors: S
authors: Schultze-Mosgau
authors: Annelore
authors: A
authors: Altendorf-Hofmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D016208:Databases, Factual / Q000706:statistics & numerical data*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012042:Registries / Q000706:statistics & numerical data*; D016019:Survival Analysis; D055815:Young Adult