[Experimental study of PVPP/silicone composite automatic expanded material as implants].
OBJECTIVE
To study the feasibility of Polyvinylpolypyrrolidone (PVPP)/silicone composite automatic expanded material as implants.


METHODS
The PVPP hydrogel was mixed with silicone through the location at the high temperature. Implants with different ratio of PVPP to silicone were placed under the back and nose skin in 24 New Zealand rabbits. The surrounding tissue reaction, material and skin expansion were observed and compared with those with pure silicone implants.


RESULTS
The study lasted for 200 days. Compared with pure silicone implants, the composite material could expand automatically and stop expanding at about 2 weeks after implantation. Histological study showed similar inflectional and foreign body reaction around the composite material and the pure silicone.


CONCLUSIONS
Compared with pure silicone, the PVPP/silicone composite implant has the advantage of automatic expansion, so as to expand the soft tissue.
Yin
Wei-min
WM
Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China.
Gao
Jian-hua
JH
Yang
Qing-fang
QF
Lu
Feng
F
Ye
Jia-jia
JJ
D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D008297:Male; D008422:Materials Testing; D011205:Povidone / Q000031:analogs & derivatives*; D019736:Prostheses and Implants; D011474:Prosthesis Design; D011817:Rabbits
D001672:Biocompatible Materials; C077842:polyvinylpolypyrrolidone; D011205:Povidone