title: Difference of climbing fiber input sources between the primate oculomotor-related cerebellar vermis and hemisphere revealed by a retrograde tracing study.
abstract: The cerebellar flocculus-paraflocculus complex, vermal lobule VII (V-7) and hemispheric lobule VII (H-7) are involved in learning-dependent smooth pursuit eye movement control. To locate the sources of climbing fiber inputs to the H-7 and V-7, we injected retrograde tracers and examined the locations of retrogradely labeled neurons in the inferior olive in 4 monkeys. After the injection of cholera toxin B (CTB) into the H-7, retrogradely labeled neurons were observed abundantly in cell group d, i.e., dorsal cap, of the caudal medial accessory olive (MAO) and ventral lamella of principal olive (PO). After injections of fast blue (FB) into the V-7, retrogradely labeled neurons were observed mainly in cell group b of MAO, but rarely in cell group d or PO. Cell group d is known to receive inputs from the nucleus optic tract (NOT) and project climbing fibers to the flocculus and ventral paraflocculus, and cell group b is known to receive inputs from the superior colliculus. These results suggest that the three oculomotor cerebellar areas may use different visual signals for the control of smooth pursuit: the flocculus-paraflocculus complex and H-7 receive visual climbing fiber inputs derived mainly from the NOT via cell group d, while the V-7 receive visual climbing fiber inputs derived mainly from the superior colliculus via cell group b.
authors: Laboratory for Motor Learning Control, RIKEN BSI, Hirosawa 2-1, Wako, Saitama 351-0198, Japan.
authors: Hiromasa
authors: H
authors: Kitazawa
authors: Guoxiang
authors: G
authors: Xiong
authors: Takahito
authors: T
authors: Hiramatsu
authors: Masafumi
authors: M
authors: Ohki
authors: Soichi
authors: S
authors: Nagao
mesh_terms: D000578:Amidines / Q000008:administration & dosage; D000818:Animals; D002531:Cerebellum / Q000033:anatomy & histology* / Q000166:cytology; D002772:Cholera Toxin / Q000008:administration & dosage; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008636:Mesencephalon / Q000033:anatomy & histology / Q000166:cytology; D008845:Microinjections; D009434:Neural Pathways / Q000033:anatomy & histology / Q000166:cytology; D009474:Neurons / Q000166:cytology; D009847:Olivary Nucleus / Q000033:anatomy & histology* / Q000166:cytology; D010784:Photomicrography
chemical_list: D000578:Amidines; C031455:diamidino compound 253-50; D002772:Cholera Toxin