Alzheimer's amyloid-beta rescues yeast from hydroxide toxicity.
Amyloid-beta(Abeta42), which is known to be toxic to neuronal cells, protects yeast cells from severe sodium hydroxide toxicity. More than 85% cell death was caused by treatment with 1 mM NaOH and approximately 95% was observed at a 2 mM concentration. However, greater than 55% cells survived the treatment in the presence of Abeta42. A strong protective effect of the peptide was also evident from the differential staining of the treated culture with propidium iodide.
Dubey
Ashok K
AK
CSIRO Molecular and Health Technologies and Preventive Health Flagship, Parkville, VIC, Australia.
Bharadwaj
Prashant R
PR
Varghese
Joseph N
JN
Macreadie
Ian G
IG
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000502:physiology*; D041221:Candida glabrata / Q000187:drug effects / Q000502:physiology*; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006878:Hydroxides / Q000633:toxicity*; D010446:Peptide Fragments / Q000502:physiology*; D012972:Sodium Hydroxide / Q000633:toxicity
D016229:Amyloid beta-Peptides; D006878:Hydroxides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D012972:Sodium Hydroxide; C031356:hydroxide ion