Grade II atypical choroid plexus papilloma with normal karyotype.
OBJECTIVE
Cytogenetic studies of atypical choroid plexus papillomas (CPP) have been poorly described. In the present report, the cytogenetic investigation of an atypical CPP occurring in an infant is detailed.


METHODS
CPP chromosome preparations were analyzed by giemsa-trypsin-banding (GTG-banding) and comparative genome hybridization (CGH).


RESULTS
Conventional karyotype analysis of tumor culture showed a normal chromosome complement. The results were confirmed by CGH, showing normal hybridization patterns for the sample.


CONCLUSIONS
To date, the few atypical CPPs described in the literature have shown disparate cytogenetic information. This is the first report of a normal chromosome complement in atypical CPP. The heterogenic genetic features observed in these small series may reflect the diverse genetic background of choroid plexus tumors in children.
Brassesco
María Sol
MS
Division of Pediatric Oncology, Department of Pediatrics, University of São Paulo, São Paulo, Brazil. marsol@rge.fmrp.usp.br
Valera
Elvis Terci
ET
Becker
Aline Paixão
AP
Oliveira
Ricardo Santos
RS
Scrideli
Carlos Alberto
CA
Machado
Hélio Rubens
HR
Tone
Luiz Gonzaga
LG
D002831:Choroid Plexus / Q000601:surgery; D016545:Choroid Plexus Neoplasms / Q000235:genetics / Q000601:surgery; D003582:Cytogenetics; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D020288:Papilloma, Choroid Plexus / Q000235:genetics* / Q000601:surgery; D016896:Treatment Outcome