Reversible metronidazole-induced cerebellar toxicity in a multiple transplant recipient.
Metronidazole-induced central nervous system (CNS) toxicity causes a spectrum of neurological symptoms including ataxia, encephalopathy and peripheral neuropathy. It is associated with characteristic MRI changes of high signal intensity in the dentate nuclei. Given the increasing use of metronidazole, it is import to recognise this drug as a cause of ataxia, as it is entirely reversible on drug withdrawal.
Graves
Tracey D
TD
Department of Neurology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0NS, United Kingdom.
Condon
Marie
M
Loucaidou
Marina
M
Perry
Richard J
RJ
D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001259:Ataxia / Q000139:chemically induced* / Q000473:pathology; D001921:Brain / Q000187:drug effects / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation; D008279:Magnetic Resonance Imaging; D008297:Male; D008795:Metronidazole / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D016035:Pancreas Transplantation
D000890:Anti-Infective Agents; D008795:Metronidazole