Antimicrobial, antiproliferative, cytotoxic, and tau inhibitory activity of rubellins and caeruleoramularin produced by the phytopathogenic fungus Ramularia collo-cygni.
Photodynamically active anthraquinone derivatives produced by the phytopathogenic fungus Ramularia collo-cygni are known to cause a barley leaf-spot disease, but data about light-dependent and independent bioactivity have been sparse to date. We therefore conducted for the first time a broad bioactivity profiling of rubellins B, C, D, and E and caeruleoramularin. Antibacterial but not antiviral activity is reported with light-dependent increase. Furthermore, when tested without illumination, compounds exerted antiproliferative and cytotoxic activity in a series of human tumor cell lines. Inhibition of tau protein assembly was observed as well.
Miethbauer
Sebastian
S
Institute of Pharmacy, University of Jena, Jena, Germany.
Gaube
Friedemann
F
Möllmann
Ute
U
Dahse
Hans-Martin
HM
Schmidtke
Michaela
M
Gareis
Manfred
M
Pickhardt
Marcus
M
Liebermann
Bernd
B
D000880:Anthraquinones / Q000494:pharmacology / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001203:Ascomycota / Q000737:chemistry*; D002018:Bufanolides / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D001467:Hordeum; D006801:Humans; D008027:Light; D003904:Mitosporic Fungi / Q000737:chemistry*; D010935:Plant Diseases; D016875:tau Proteins / Q000037:antagonists & inhibitors*
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D002018:Bufanolides; D016875:tau Proteins