title: Morel's laminar sclerosis showing apraxia of speech: distribution of cortical lesions in an autopsy case.
abstract: A 57-year old man with chronic alcoholism presented with apraxia of speech and disturbance of consciousness. He had a history of gastrectomy and had been drinking alcohol. The symptoms improved with administration of thiamine, but he later developed diarrhea and delirium, and died approximately 40 days after the onset. Autopsy findings were consistent with Wernicke's encephalopathy and pellagra encephalopathy. Furthermore, laminar cortical necrosis with vacuoles and astrocytosis was found in the second and third layers of the bilateral frontal cortices, suggesting Morel's laminar sclerosis. The lesions were mainly located in the bilateral primary motor cortices. Involvement of the lower part of the left primary motor cortex may be associated with apraxia of speech in our case.
authors: Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo 156-8585, Japan. Email: zen@bg7.so-net.ne.jp
authors: Zen
authors: Z
authors: Kobayashi
authors: Kuniaki
authors: K
authors: Tsuchiya
authors: Mafuyu
authors: M
authors: Takahashi
authors: Osamu
authors: O
authors: Yokota
authors: Kazuhiro
authors: K
authors: Taki
authors: Hideki
authors: H
authors: Ishizu
authors: Tetsuaki
authors: T
authors: Arai
authors: Haruhiko
authors: H
authors: Akiyama
authors: Hidehiro
authors: H
authors: Mizusawa
mesh_terms: D000437:Alcoholism / Q000188:drug therapy / Q000473:pathology; D001072:Apraxias / Q000473:pathology*; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology*; D002908:Chronic Disease; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex; D012598:Sclerosis / Q000473:pathology; D013064:Speech Disorders / Q000473:pathology*; D013831:Thiamine / Q000627:therapeutic use; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D014803:Vitamin B Complex; D013831:Thiamine