title: Alzheimer's amyloid-beta rescues yeast from hydroxide toxicity.
abstract: Amyloid-beta(Abeta42), which is known to be toxic to neuronal cells, protects yeast cells from severe sodium hydroxide toxicity. More than 85% cell death was caused by treatment with 1 mM NaOH and approximately 95% was observed at a 2 mM concentration. However, greater than 55% cells survived the treatment in the presence of Abeta42. A strong protective effect of the peptide was also evident from the differential staining of the treated culture with propidium iodide.
authors: CSIRO Molecular and Health Technologies and Preventive Health Flagship, Parkville, VIC, Australia.
authors: Ashok K
authors: AK
authors: Dubey
authors: Prashant R
authors: PR
authors: Bharadwaj
authors: Joseph N
authors: JN
authors: Varghese
authors: Ian G
authors: IG
authors: Macreadie
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000502:physiology*; D041221:Candida glabrata / Q000187:drug effects / Q000502:physiology*; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006878:Hydroxides / Q000633:toxicity*; D010446:Peptide Fragments / Q000502:physiology*; D012972:Sodium Hydroxide / Q000633:toxicity
chemical_list: D016229:Amyloid beta-Peptides; D006878:Hydroxides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D012972:Sodium Hydroxide; C031356:hydroxide ion