Gabapentin for the treatment of pain related to radiation-induced mucositis in patients with head and neck tumors treated with intensity-modulated radiation therapy.
BACKGROUND
This retrospective study evaluates the efficacy of gabapentin for the treatment of pain syndrome related to radiation-induced mucositis in patients with head and neck tumors.


METHODS
Thirty cases of head and neck malignancies treated with radiotherapy were analyzed.


RESULTS
By using a median dose of 2700 mg/day of gabapentin, only 10% of patients required additional narcotic pain medications for adequate pain relief during the third and fourth week of treatment, despite grade 2 or higher mucositis present in 56% and 73% of the patients, respectively. Likewise, during the last weeks of intensity-modulated radiation therapy (IMRT), only 35% of patients required additional narcotics for pain control, despite the presence of grade 2 or higher mucositis in 80% of cases.


CONCLUSIONS
Gabapentin appears promising in reducing the need for narcotic pain medication for patients with head and neck malignancies treated with IMRT and should be further evaluated prospectively in controlled clinical trials.
Bar Ad
Voichita
V
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. barad@xrt.upenn.edu
Weinstein
Gregory
G
Dutta
Pinaki R
PR
Chalian
Ara
A
Both
Stefan
S
Quon
Harry
H
D000588:Amines / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D003680:Deglutition Disorders / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D000077206:Gabapentin; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D052016:Mucositis / Q000145:classification / Q000188:drug therapy* / Q000209:etiology; D010146:Pain / Q000188:drug therapy*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects; D012189:Retrospective Studies; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin