Malaria antigen-mediated enhancement of interleukin-21 responses of peripheral blood mononuclear cells in African adults.
We recently showed that IL-21 is associated with high level of anti-EBA-175 IgG1 and IgG3. Here we have investigated the ability of two malarial antigens, Glutamate-rich protein and merozoite surface protein 3 to induce IL-21 production from PBMCs from malaria-exposed and non-exposed donors. We found that malaria-exposed donors produced significantly more IL-21 compared to non-exposed donors. These data suggest that IL-21 could be involved in the acquisition of immunity to malaria.
Mewono
Ludovic
L
Medical Research Unit, Albert Schweitzer Hospital, P.O. Box 118, Lambaréné, Gabon. mewono2@yahoo.fr
Agnandji
Selidji T
ST
Matondo Maya
Davy W
DW
Mouima
Anne-Marie Nkoma
AM
Iroungou
Berthe A
BA
Issifou
Saadou
S
Kremsner
Peter G
PG
D000293:Adolescent; D000328:Adult; D000953:Antigens, Protozoan / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D007378:Interleukins / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D017780:Malaria Vaccines / Q000276:immunology; D016778:Malaria, Falciparum / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*; D055815:Young Adult; D000098546:Interleukin-21
D000953:Antigens, Protozoan; D007378:Interleukins; D017780:Malaria Vaccines; D015800:Protozoan Proteins; C089133:merozoite surface protein 3, Plasmodium; D016753:Interleukin-10; C072492:glutamate-rich protein, Plasmodium; D007371:Interferon-gamma; D000098546:Interleukin-21