Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study.
Oxidative stress in the brain is suggested to be involved in the pathophysiology of Alzheimer's disease (AD). In this study, serum alpha- and gamma-tocopherol, the two major systemic antioxidants, were analyzed at two examinations of the ULSAM-study, a longitudinal, community-based study of elderly men (age 70, n = 616 and age 77, n = 761). In addition, urinary F2-isoprostane levels, as markers of systemic oxidative stress, were analyzed at the age of 77 in this cohort (n = 679). Cox regression analyses were used to examine associations between serum alpha-, gamma-tocopherol and urinary F2-isoprostane levels and AD, any type of dementia (all-cause dementia) and non-AD dementia. On follow-up (median, 12.3 years), 40 subjects developed AD and 86 subjects developed all-cause dementia. Serum alpha- and gamma-tocopherol or urinary F2-isoprostane levels were not associated with the future risk of AD or dementia. In conclusion, systemic serum alpha- and gamma-tocopherol and urinary F2-isoprostane levels are not associated with the future risk of AD or dementia and do not seem to be useful predictors of clinical AD or dementia.
Sundelöf
Johan
J
Department of Public Health and Caring Sciences/Geriatrics, Faculty of Medicine, Uppsala University, Uppsala, Sweden.
Kilander
Lena
L
Helmersson
Johanna
J
Larsson
Anders
A
Rönnemaa
Elina
E
Degerman-Gunnarsson
Malin
M
Sjögren
Per
P
Basun
Hans
H
Lannfelt
Lars
L
Basu
Samar
S
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis / Q000652:urine*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D003704:Dementia / Q000097:blood / Q000175:diagnosis / Q000652:urine; D028441:F2-Isoprostanes / Q000652:urine*; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011153:Population; D011446:Prospective Studies; D012307:Risk Factors; D024505:Tocopherols / Q000097:blood*
D015415:Biomarkers; D028441:F2-Isoprostanes; D024505:Tocopherols