Interaction of indoleamine-2,3-dioxyagnase and CD4+CD25+ regulatory T cells in tumor immune escape.
There are numerous factors involved in the tumor evasion from immune surveillance. Recently, considerable attention has been given to indoleamine 2,3-dioxygenase (IDO) and CD4(+)CD25(+) regulatory T cells (Tregs). The interaction between the two may play a crucial role in tumor immune escape. This article reviews the correlation between IDO and Tregs in immune escape of tumors.
Wang
Hui
H
State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, PR China.
Pan
Ke
K
Xia
Jian-Chuan
JC
D000818:Animals; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism*; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D008954:Models, Biological; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D019139:Tumor Escape / Q000276:immunology*
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D053645:Interleukin-2 Receptor alpha Subunit; C529271:EIF2AK4 protein, human; D017346:Protein Serine-Threonine Kinases