Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia.
A methanol extract of the twigs of Cinnamomum cassia was found to possess inhibitory activity against tyrosinase. Purification of the MeOH extract afforded four new phenolics, cassiferaldehyde (6), icariside DC (9), cinnacassinol (10), and dihydrocinnacasside (13), together with 10 known compounds (1-5, 7-12, and 14). The structures of the new compounds were determined by spectroscopic data interpretation. Compounds 1-6 and 8-13 showed strong inhibitory activity against tyrosinase, with IC(50) values ranging from 0.24 to 0.94 mM.
Ngoc
Tran Minh
TM
College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea.
Lee
IkSoo
I
Ha
Do Thi
do T
Kim
Hongjin
H
Min
ByungSun
B
Bae
KiHwan
K
D032904:Cinnamomum aromaticum / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007723:Korea; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D006027:Glycosides; D010636:Phenols; D014442:Monophenol Monooxygenase