[The role of free and esterified fatty acids in pathogenesis of metabolic syndrome].
Patients with insulin resistance and those with metabolic syndrome (MS) in the absence of alteration of glucose-insulin homeostasis were found to have abnormal composition of plasma free fatty acids (FA) and lipid FA in erythrocytes. Patients with metabolic syndrome and different glucose-insulin homeostasis accumulated polyenic FA and lost saturated FA in plasma; saturated FA in their erythrocytes increased while polyunsaturated FA decreased. These findings suggest disturbed receptor-mediated active transport of FA and the predominance of passive absorption of free FA by cells as a cause of insulin resistance and hyperinsulinism.
Novgorodtseva
T P
TP
Karaman
Iu K
IuK
Antoniuk
M V
MV
Zhukova
N V
NV
D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005227:Fatty Acids / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology; D008875:Middle Aged
D015415:Biomarkers; D001786:Blood Glucose; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007328:Insulin