The myeloperoxidase gene and its influence on myocardial infarction in a Swedish population: protective role of the -129A allele in women.
OBJECTIVE
The aim of this study is to investigate the potential role of functional myeloperoxidase (MPO) promoter polymorphisms in the occurrence of myocardial infarction (MI) in the Stockholm Heart Epidemiology Program.


RESULTS
Two MPO promoter polymorphisms, -129G/A and -463G/A, were genotyped in the Stockholm Heart Epidemiology Program population (n = 2774). The -129A allele was associated with a lower risk of MI in women [odds ratio (OR) (95% confidence interval): 0.65 (0.43-0.98), P = 0.03] but not in men [OR: 1.12 (0.86-1.47), P = 0.38]. When women were stratified by age and hormone replacement therapy, the protective effect of the -129A allele was only evident in women younger than 55 years or not receiving hormone replacement therapy. In these two groups, OR (95% confidence interval) for carriers of the -129A allele were 0.34 (0.12-0.92) (P = 0.03) and 0.51 (0.32-0.81) (P = 0.004), respectively. For the -463G/A polymorphism, no associations to MI risk were observed either in women or in men.


CONCLUSIONS
The A allele of the MPO -129G/A promoter polymorphism is associated with a reduced MI risk in women.
Zotova
Elena
E
of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm S-171 77, Sweden.
Lyrenäs
Louise
L
de Faire
Ulf
U
Morgenstern
Ralf
R
Gigante
Bruna
B
Bennet
Anna M
AM
D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D016017:Odds Ratio; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology; D016387:Women's Health
D009195:Peroxidase