title: Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout.
abstract: OBJECTIVE
  Molecular biological approaches have recently identified urate transporters in renal proximal tubular cells. Human sodium-dependent phosphate cotransporter type 1 encoded by SLC17A1 is a urate transporter localised to the renal proximal tubular cells and candidate molecule to secret urate from renal tubular cells to urine. This study investigated the roles of SLC17A1 in the development of gout.
  
  
  METHODS
  Single nucleotide polymorphisms in the human SLC17A1 gene (rs1165176, rs1165151, rs1165153, rs1165196, rs1165209, rs1165215, rs1179086, rs3799344 and rs3757131) were selected, and an association study was conducted using male patients with gout (n=175) and male controls (n=595).
  
  
  RESULTS
  There were significant differences between gout and control groups in the distribution of genotypes at rs1165196 (T806C; Ile269Thr, odds ratio (OR) 0.55, p=0.0035), rs1179086 (OR 0.57, p=0.0018) and rs3757131 (OR 0.54, p=0.0026). In controls, T806C alone had no effect on serum uric acid (sUA) levels. However, T806C showed significant interaction with a reduction of sUA in obese individuals (body mass index > or = 25) using multiple regression analysis.
  
  
  CONCLUSIONS
  Our data suggest that SLC17A1 polymorphisms are associated with the development of gout.
authors: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Sinjuku-ku, Tokyo 162-0054, Japan. wako@ior.twmu.ac.jp
authors: Wako
authors: W
authors: Urano
authors: Atsuo
authors: A
authors: Taniguchi
authors: Naohiko
authors: N
authors: Anzai
authors: Eisuke
authors: E
authors: Inoue
authors: Yoshikatsu
authors: Y
authors: Kanai
authors: Mariko
authors: M
authors: Yamanaka
authors: Hitoshi
authors: H
authors: Endou
authors: Naoyuki
authors: N
authors: Kamatani
authors: Hisashi
authors: H
authors: Yamanaka
mesh_terms: D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006073:Gout / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D050609:Sodium-Phosphate Cotransporter Proteins, Type I / Q000235:genetics*
chemical_list: D050609:Sodium-Phosphate Cotransporter Proteins, Type I