title: Substitution of 11C-methionine PET by perfusion MRI during the follow-up of treated high-grade gliomas: preliminary results in clinical practice.
abstract: OBJECTIVE
  Our aim was to compare perfusion magnetic resonance imaging (MRI) and positron emission tomography (PET) using carbon-11 labelled methionine (MET) in gliomas and their value in differentiating tumour recurrence from necrosis.
  
  
  METHODS
  We retrospectively reviewed 28 patients with a high-grade glioma. A total of 33MR perfusions and MET-PET were ultimately analysable for comparison between the relative cerebral blood volume (rCBV) and MET-PET examinations. Intra- and interobserver reproducibility was assessed and diagnostic value of rCBV compared to MET-PET and histology was assessed by the area under the receiver operating characteristic (ROC) curve.
  
  
  RESULTS
  ROC curve analysis showed that rCBV had at least equal performances in differentiating tumour recurrence and necrosis than MET-PET. Cut-off value of rCBV for differentiating tumour from necrosis was 182% with a sensitivity of 81.5% and a specificity of 100%.
  
  
  CONCLUSIONS
  In clinical practice, perfusion MRI could replace MET-PET for differentiating necrosis from tumour recurrence.
authors: Department of Medical Imaging, MRI Unit, cliniques universitaires Saint-Luc, université catholique de Louvain, 10, avenue Hippocrate, 1200 Brussels, Belgium. vinciane.dandois@advalvas.be
authors: V
authors: V
authors: Dandois
authors: D
authors: D
authors: Rommel
authors: L
authors: L
authors: Renard
authors: J
authors: J
authors: Jamart
authors: G
authors: G
authors: Cosnard
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002250:Carbon Radioisotopes; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008715:Methionine; D008875:Middle Aged; D009336:Necrosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D015588:Observer Variation; D049268:Positron-Emission Tomography / Q000379:methods*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D002250:Carbon Radioisotopes; D008715:Methionine