title: Effects of neuronal and glial restricted precursor cells transplantation on erectile function after experimentally induced spinal cord injury.
abstract: BACKGROUND
  Erectile dysfunction is common among patients with spinal cord injury (SCI).
  
  
  OBJECTIVE
  This study aims to investigate the recovery of penile erectile functions of the rats with spinal cord injury (SCI) following transplantation of endogenous neuronal precursors cell (neuronal restricted precursors [NRP]/glial restricted precursors [GRP]) into the injured area of spinal cord.
  
  
  METHODS
  Twenty-two rats were experimented in three groups. Group 1 (N = 6): Sham; Group 2 (N = 10): SCI + NRP/GRP transplanted in day 9 after operation; Group 3 (N = 6): SCI + culture medium transplanted in day 9 after operation. Analysis of penile reflexes and cavernosal nerve stimulation studies were performed in day 28 after transplantation for each group. All rats in three groups were then sacrificed and the injured regions of spinal cords underwent histological investigation.
  
  
  METHODS
  These results show improvements to some extent in locomotor and erectile functions although these improvements are far from full functional recovery.
  
  
  RESULTS
  Cavernosal nerve stimulation resulted in significantly higher intracavernosal pressure in Group 3 (SCI) although there was no difference between Group 1 (sham) and Group 2 (SCI + NRP/GRP). Number of clusters was similar between groups. Number of erections was higher in Group 3 (SCI) than Groups 1 and 2, and number of cups was higher in Group 2 (SCI + NRP/GRP) than the other two groups. Number of flips was similar in Groups 1 and 2 but lower in Group 3. Number of long flips was highest in Group 1 and lowest in Group 3. The differences between groups were significant.
  
  
  CONCLUSIONS
  This study emphasized the healing potential of NRP/GRP transplantation following experimental SCI. However, further experimental and clinical studies are required to advance this treatment modality.
authors: Department of Urology, Medical Faculty, Celal Bayar University, Manisa, Turkey. temeltasg@yahoo.com
authors: Gokhan
authors: G
authors: Temeltas
authors: Taner
authors: T
authors: Dagci
authors: Vedat
authors: V
authors: Evren
authors: Murat
authors: M
authors: Lekili
mesh_terms: D000818:Animals; D017690:Cell Transplantation / Q000379:methods*; D004195:Disease Models, Animal; D007172:Erectile Dysfunction / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D008124:Locomotion / Q000502:physiology; D008297:Male; D009457:Neuroglia / Q000166:cytology / Q000637:transplantation*; D051381:Rats; D020127:Recovery of Function; D012720:Severity of Illness Index; D013119:Spinal Cord Injuries / Q000150:complications*; D016896:Treatment Outcome