Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy.
Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.
Ross
Robert W
RW
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA.
Zietman
Anthony L
AL
Xie
Wanling
W
Coen
John J
JJ
Dahl
Douglas M
DM
Shipley
William U
WU
Kaufman
Donald S
DS
Islam
Tina
T
Guimaraes
Alexander R
AR
Weissleder
Ralph
R
Harisinghani
Mukesh
M
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000368:Aged; D003287:Contrast Media; D003911:Dextrans; D052203:Ferrosoferric Oxide; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007501:Iron; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D053758:Nanoparticles; D010087:Oxides; D011300:Preoperative Care; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D020266:Radiotherapy, Conformal; D015203:Reproducibility of Results; D016879:Salvage Therapy; D012680:Sensitivity and Specificity
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide