title: Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles.
abstract: OBJECTIVE
  To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes.
  
  
  METHODS
  Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist down-regulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer.
  
  
  RESULTS
  Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes.
  
  
  CONCLUSIONS
  Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes.
authors: Department of Obstetrics and Gynecology, Good Samaritan Hospital, 3219 Clifton Ave. Suite #100, Cincinnati, OH 45220, USA. Matthew_Barker@trihealth.com
authors: Matthew A
authors: MA
authors: Barker
authors: Lynn M
authors: LM
authors: Boehnlein
authors: Peter
authors: P
authors: Kovacs
authors: Steven R
authors: SR
authors: Lindheim
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000378:metabolism; D004717:Endometrium / Q000473:pathology*; D004967:Estrogens / Q000097:blood; D005260:Female; D005498:Follicular Phase; D006801:Humans; D008183:Luteal Phase; D018587:Oocyte Donation; D009865:Oocytes / Q000166:cytology; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000097:blood
chemical_list: D006063:Chorionic Gonadotropin; D004967:Estrogens; D011374:Progesterone