title: The effects of perindopril on aortic elasticity and inflammatory markers in hypertensive patients.
abstract: BACKGROUND
  Inflammation plays an important role in hypertension and in atherosclerosis. Inflammatory changes induced even in prehypertensive subjects can lead to increased arterial stiffness. The effects of perindopril on both inflammatory and aortic elasticity markers were tested in hypertensive patients.
  
  
  METHODS
  One hundred nine hypertensive patients not taking any antihypertensive therapy were included in the study. Aortic strain, aortic distensibility, aortic stiffness index, and inflammatory markers, including CRP, IL-1alpha IL-1beta, and TNF-alpha, were measured in all patients before and after twenty weeks of perindopril therapy.
  
  
  RESULTS
  While aortic strain and distensibility showed statistically significant increases with perindopril therapy, the aortic stiffness index and inflammatory markers were found to decrease.
  
  
  CONCLUSIONS
  Perindopril therapy resulted in an improvement in aortic elastic properties. There was also an attenuation of inflammatory status of the patients as reflected by lower inflammatory marker levels compared with pretreatment values.
authors: Department of Cardiology, Gulhane Military Medical School, Etlik, Ankara, Turkey.
authors: Cem
authors: C
authors: Koz
authors: Oben
authors: O
authors: Baysan
authors: Mehmet
authors: M
authors: Yokusoglu
authors: Mehmet
authors: M
authors: Uzun
authors: Mustafa
authors: M
authors: Yildirim
authors: Adnan
authors: A
authors: Hasimi
authors: Bilgehan Savas
authors: BS
authors: Oz
authors: Kursad
authors: K
authors: Erinc
authors: Hayrettin
authors: H
authors: Karaeren
authors: Huseyin
authors: H
authors: Celebi
authors: Ersoy
authors: E
authors: Isik
mesh_terms: D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D004548:Elasticity / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D020913:Perindopril