Egg shell membrane as a substrate for optimizing in vitro transbuccal delivery of glipizide.
Buccoadhesive gels for transbuccal delivery of glipizide were prepared using different bio-adhesive polymers. The gels were prepared by solution polymerization technique. An apparatus simulating the in vivo conditions of the mouth was designed in order to assess in vitro drug release kinetics of these gels. The gels were also evaluated for spreadability, buccoadhesive strength, swelling index, and viscosity. Maximum buccoadhesive strength was observed for formulation, F8 with good sustained release behavior, whereas viscosity and swelling index was highest for the formulation, F5 but with minimum buccoadhesive strength. The drug release kinetics followed Higuchi model with release mechanism being Fickian diffusion.
Philip
Anil K
AK
Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura-286001, Uttar Pradesh, India. philipanil23@yahoo.co.in
Singh
Nisha
N
Pathak
Kamla
K
D000268:Adhesiveness; D000278:Administration, Buccal; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004528:Egg Shell / Q000378:metabolism; D004867:Equipment Design; D005782:Gels / Q000737:chemistry*; D005913:Glipizide / Q000008:administration & dosage*; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008566:Membranes / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D014783:Viscosity; D014867:Water / Q000737:chemistry
D003692:Delayed-Action Preparations; D005782:Gels; D007004:Hypoglycemic Agents; D011108:Polymers; D014867:Water; D005913:Glipizide