title: Hepatosplenic gammadelta T-cell lymphoma after liver transplantation: report of the first 2 cases and review of the literature.
abstract: Hepatosplenic gammadelta T-cell lymphoma is a rare lymphoproliferative disorder originating from natural killer-like Vdelta1-lymphocytes. This subtype has been described after different types of solid organ transplants. In this article, we describe the first 2 cases after liver transplantation. Both patients had thrombocytopenia with (hepato)splenomegaly but without peripheral lymphadenopathies and sinusoidal infiltration of the liver and spleen by monomorphic gammadelta-lymphocytes on pathological examination. The clinical and pathological findings, immunophenotypical profile, prognosis, and treatment are highlighted. In order to make an early diagnosis, physicians who take care of liver transplant recipients should be aware of the characteristic features of this posttransplant lymphoproliferative disorder. Therefore, a diagnostic algorithm is proposed.
authors: Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium.
authors: Philip R
authors: PR
authors: Roelandt
authors: Johan
authors: J
authors: Maertens
authors: Peter
authors: P
authors: Vandenberghe
authors: Chris
authors: C
authors: Verslype
authors: Tania
authors: T
authors: Roskams
authors: Raymond
authors: R
authors: Aerts
authors: Frederik
authors: F
authors: Nevens
authors: Daan
authors: D
authors: Dierickx
mesh_terms: D000328:Adult; D000465:Algorithms; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000209:etiology* / Q000628:therapy; D008113:Liver Neoplasms / Q000209:etiology / Q000628:therapy; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008495:Medical Oncology / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D011379:Prognosis; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D013160:Splenic Neoplasms / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta