Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats.
In this study, we performed tests to determine whether tooth pulp stimulation (TPS) increases hippocampal blood flow (HBF), and if so, to investigate whether the increase in HBF is mediated via the activation of adenosine receptors. We measured HBF in urethane-anesthetized rats using laser Doppler flowmetry (LDF) and examined the effect of theophylline, a nonselective adenosine receptor antagonist, on TPS-induced HBF responses. TPS increased HBF, and its response was significantly attenuated by the intraperitoneal administration of theophylline (20 mg/kg). These results suggest that the HBF response induced by TPS may be, at least in part, produced through adenosine receptors.
Hasegawa
Makoto
M
Department of Dentistry and Oral Surgery, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. m-hase@hyo-med.ac.jp
Hada
Junichi
J
Abe
Tetsuya
T
Honda
Kousuke
K
Shimizu
Akihiko
A
Urade
Masahiro
M
D000241:Adenosine / Q000378:metabolism; D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002536:Cerebral Arteries / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D003786:Dental Pulp Cavity / Q000294:innervation / Q000503:physiopathology*; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000009:adverse effects; D006624:Hippocampus / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D017078:Laser-Doppler Flowmetry; D008297:Male; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D017208:Rats, Wistar; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology*; D014098:Toothache / Q000378:metabolism / Q000503:physiopathology*; D014665:Vasodilator Agents / Q000494:pharmacology
D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1; D014665:Vasodilator Agents; D013806:Theophylline; D000241:Adenosine