Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages.
Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 microM against several human tumor cell lines.
Kuo
Yu-Jen
YJ
National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
Hsiao
Ping-Chun
PC
Zhang
Li-Jie
LJ
Wu
Ming-Der
MD
Liang
Yu-Han
YH
Ho
Hsiu-O
HO
Kuo
Yao-Haur
YH
D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular
D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D008070:Lipopolysaccharides; C433017:labdane; D009569:Nitric Oxide