title: Clinical, histologic, and immunohistochemical features of an undifferentiated renal tubular carcinoma in a juvenile olive baboon (Papio anubis).
abstract: An undifferentiated renal tubular carcinoma was diagnosed in a juvenile male olive baboon (Papio anubis). The animal suddenly appeared depressed and refused to eat. During physical examination, a firm, palpable mass in the left abdominal area and flank pain were detected. Clinical pathology findings included mild anemia, hypoalbuminemia, hyponatremia, and mildly increased serum creatinine and urea concentrations. Radiographs revealed a large mass in the left abdominal area. Exploratory laparotomy disclosed a 10 cmx15 cm multilobulated mass involving the left kidney and adjacent organs. Because of a poor prognosis, the animal was humanely euthanized, and necropsy was performed. Tissue samples of the neoplasm were taken for histopathological examination. Immunohistochemical staining was done using vimentin, cytokeratin, S-100 protein, Ki-67, alpha-actin, and desmin-specific primary antibodies. Microscopically, elongated and irregular tubules were lined by 2 or more layers of atypical epithelial cells. Anisocytosis, anisokaryosis, and frequent mitotic figures were also observed. Following immunohistochemical staining, the cytoplasm of neoplastic cells was positive for cytokeratin, vimentin, and S-100 protein and negative for alpha-actin and desmin. Positive nuclear staining for Ki-67 was observed. The neoplasm was diagnosed as an undifferentiated renal tubular carcinoma.
authors: Department of Animal Production, University of Murcia, Murcia, Spain.
authors: Nuria
authors: N
authors: García
authors: Guillermo
authors: G
authors: Ramis
authors: Francisco J
authors: FJ
authors: Pallarés
authors: Juan I
authors: JI
authors: Seva
authors: Carlos M
authors: CM
authors: Martínez
authors: Juan J
authors: JJ
authors: Quereda
authors: Antonio
authors: A
authors: Muñoz
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000145:classification / Q000473:pathology / Q000662:veterinary*; D007680:Kidney Neoplasms / Q000145:classification / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008992:Monkey Diseases / Q000145:classification / Q000473:pathology*; D048530:Papio anubis