HMW-adiponectin associates with triglyceride concentrations in type 1 diabetic patients.
OBJECTIVE
The objective of this study was to investigate the relation between serum high molecular weight (HMW)-adiponectin concentration and fasting and postprandial blood glycemic and lipid parameters in type 1 diabetic patients.


METHODS
Type 1 diabetic patients treated with short-acting insulin analogs and healthy volunteers were recruited. The subjects were divided into two groups based on the mean HMW-adiponectin value of 12.2 mg/L: low HMW-adiponectin (men/women=7/2) and high HMW-adiponectin (men/women=3/8). Blood samples were collected after an overnight fast, and 30180 min after consuming white bread (B) or white bread with butter (BB).


RESULTS
Type 1 diabetic patients with high HMW-adiponectin had lower triglyceride and remnant like particle (RLP)-triglyceride concentrations than those with low HMW-adiponectin (p<0.01), and had a higher lipoprotein lipase mass (p<0.01) than healthy subjects (men/women=8/6). After B and BB meals, type 1 diabetic patients with high HMW-adiponectin consistently had lower triglyceride and RLP-triglyceride concentrations for up to 180 min than those with low HMW-adiponectin (p<0.01); however, apoB48 did not differ between these two groups. Fasting and postprandial plasma glucose were higher in both diabetic groups than in healthy subjects (p<0.001), with no significant difference between patient groups.


CONCLUSIONS
HMW-adiponectin is more strongly associated with very low density lipoprotein remnant metabolism than glucose utilization in type 1 diabetic patients receiving short-acting insulin analogs.
Maruyama
Chizuko
C
Department of Food and Nutrition, Japan Women's University, Tokyo 112-8681, Japan. maruyama@fc.jwu.ac.jp
Ishibashi
Rieko
R
Araki
Risa
R
Koike
Shino
S
Hirose
Hiroshi
H
Maruyama
Taro
T
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005215:Fasting; D005260:Female; D006801:Humans; D006943:Hyperglycemia; D007328:Insulin / Q000031:analogs & derivatives / Q000627:therapeutic use; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014280:Triglycerides