title: Prognostic significance of adipocytokines and extracellular matrix activity in heart failure patients with high B-type natriuretic peptide.
abstract: OBJECTIVE
  To perform risk stratification by serum adipocytokines and serum markers of extracellular matrix in heart failure patients with high b-type natriuretic peptide (BNP).
  
  
  METHODS
  Patients with heart failure were enrolled in this study. Serum adipocytokines and serum markers of extracellular matrix were analyzed.
  
  
  RESULTS
  In total, 131 patients were enrolled and followed-up for 240+/-174 days. Mortality was significantly associated with adiponectin, resistin, type III amioterminal propeptide of procollagen (PIIINP), matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase 1 (TIMP-1), and serum creatinine. Heart failure-related admission was significantly associated with apelin, and PIIINP. Cox regression analysis identified that mortality and heart failure-related admissions were significantly associated with MMP-2 (P=0.008) and PIIINP (P=0.011), respectively.
  
  
  CONCLUSIONS
  Serum markers of extracellular matrix rather than adipocytokines may warrant further risk stratification for impacting the prognosis of patients with heart failure with high BNP.
authors: Graduate Institute of Clinical Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors: Yi-Lwun
authors: YL
authors: Ho
authors: Yen-Hung
authors: YH
authors: Lin
authors: Chi-Ming
authors: CM
authors: Lee
authors: Ron-Bin
authors: RB
authors: Hsu
authors: Hsiu-Tzu
authors: HT
authors: Ting
authors: Nai-Kuan
authors: NK
authors: Chou
authors: Chia-Lun
authors: CL
authors: Chao
authors: Shoei-Shen
authors: SS
authors: Wang
authors: Hsiu-Ching
authors: HC
authors: Hsu
authors: Ming-Fong
authors: MF
authors: Chen
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000368:Aged; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000706:statistics & numerical data; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D053208:Kaplan-Meier Estimate; D016014:Linear Models; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood; D011379:Prognosis; D016016:Proportional Hazards Models; D052243:Resistin / Q000097:blood; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood
chemical_list: D054392:Adipokines; D052242:Adiponectin; D010446:Peptide Fragments; D011347:Procollagen; D052243:Resistin; D019715:Tissue Inhibitor of Metalloproteinase-1; C041876:procollagen Type III-N-terminal peptide; D020097:Natriuretic Peptide, Brain; D003404:Creatinine; D020778:Matrix Metalloproteinase 2