title: Lack of association with rheumatoid arthritis of selected polymorphisms in 4 candidate genes: CFH, CD209, eotaxin-3, and MHC2TA.
abstract: OBJECTIVE
  To investigate associations with rheumatoid arthritis (RA) of single-nucleotide polymorphisms (SNP) in 4 candidate genes, complement factor H (CFH), CD209 or DC-SIGN, eotaxin-3, and the MHC class II Transactivator (MHC2TA) genes. These SNP have been reported as important for RA (eotaxin-3 and MHC2TA) or for other immune-mediated diseases (CFH and CD209).
  
  
  METHODS
  Genotypes for the 7 selected SNP were obtained from 1587 patients with RA and 1570 controls of Spanish ancestry. Analyses were carried out after stratification for sex, erosions, rheumatoid factor, shared epitope, anti-cyclic citrullinated peptide antibodies, and the R620W PTPN22 SNP.
  
  
  RESULTS
  None of the comparisons between patients with RA and controls or between the different strata of patients according to disease features was significant.
  
  
  CONCLUSIONS
  None of the SNP in CFH and CD209 showed evidence of association with RA. We did not replicate the association of eotaxin-3 with RA described in Koreans, or that of the MHC2T SNP.
authors: Laboratorio de Investigacion 10, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
authors: Rebeca
authors: R
authors: Dieguez-Gonzalez
authors: Servet
authors: S
authors: Akar
authors: Manuel
authors: M
authors: Calaza
authors: Isidoro
authors: I
authors: Gonzalez-Alvaro
authors: Benjamin
authors: B
authors: Fernandez-Gutierrez
authors: Jose Ramon
authors: JR
authors: Lamas
authors: Arturo R
authors: AR
authors: de la Serna
authors: Rafael
authors: R
authors: Caliz
authors: Francisco J
authors: FJ
authors: Blanco
authors: Dora
authors: D
authors: Pascual-Salcedo
authors: Maria Luisa
authors: ML
authors: Velloso
authors: Eva
authors: E
authors: Perez-Pampin
authors: Jose Luis
authors: JL
authors: Pablos
authors: Federico
authors: F
authors: Navarro
authors: Javier
authors: J
authors: Narvaez
authors: Francisco Javier
authors: FJ
authors: Lopez-Longo
authors: Gabriel
authors: G
authors: Herrero-Beaumont
authors: Juan J
authors: JJ
authors: Gomez-Reino
authors: Antonio
authors: A
authors: Gonzalez
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics*; D000075906:Chemokine CCL26; D019742:Chemokines, CC / Q000235:genetics*; D017242:Complement Factor H / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics*; D013030:Spain; D015534:Trans-Activators / Q000235:genetics*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D000075906:Chemokine CCL26; D019742:Chemokines, CC; D017242:Complement Factor H; D037181:Lectins, C-Type; D009687:Nuclear Proteins; D011956:Receptors, Cell Surface; D015534:Trans-Activators; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C120429:CCL26 protein, human; C493495:CFH protein, human; C083728:MHC class II transactivator protein