title: Impaired somatic growth and delayed lung development in infants with congenital diaphragmatic hernia--evidence from a 10-year, single center prospective follow-up study.
abstract: OBJECTIVE
  In infants with congenital diaphragmatic hernia (CDH), somatic growth and pulmonary development are key issues beyond the time of intensive care treatment. The aim of the study was to investigate the somatic growth and pulmonary function after discharge and to compare CDH patients with a group of matched controls.
  
  
  METHODS
  Anthropometric measurements and lung function tests were performed in 26 infants after surgical repair of CDH and 26 non-CDH intensive care patients, matched for gestational age and birth weight. Spontaneously breathing infants were tested at a mean of 44 weeks postconceptional age (range, 36-58 weeks). Body weight, body length, respiratory rate (RR), tidal volume (V(T)), functional residual capacity by body plethysmography (FRC(pleth)), respiratory compliance (C(rs)), and respiratory resistance (R(rs)) were measured.
  
  
  RESULTS
  The mean (SD) weight gain per week in the CDH infants was significantly lower compared to non-CDH infants (89 [39] g vs 141 [49] g; P = .002). The breathing pattern between both groups differed considerably. In CDH infants, V(T) was significantly lower (P < .001) and RR significantly higher (P = .005). The respiratory compliance was also significantly (P < .001) reduced, whereas R(rs) did not differ significantly. No statistically significant differences were seen in FRC(pleth) related to the body weight between CDH and non-CDH infants (20.3 [4.4] mL/kg vs 21.5 [4.9] mL/kg).
  
  
  CONCLUSIONS
  Despite apparently well-inflated lungs after surgery, evidence of early and significantly reduced weight gain and impaired lung function in CHD patients should prompt careful dietary monitoring and regular lung function testing.
authors: Department of Neonatology, Charité Campus Mitte, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany. christoph.roehr@charite.de
authors: Charles Christoph
authors: CC
authors: Roehr
authors: Hans
authors: H
authors: Proquitté
authors: Andreas
authors: A
authors: Jung
authors: Ulrike
authors: U
authors: Ackert
authors: Christian
authors: C
authors: Bamberg
authors: Petra
authors: P
authors: Degenhardt
authors: Hannes
authors: H
authors: Hammer
authors: Roland R
authors: RR
authors: Wauer
authors: Gerd
authors: G
authors: Schmalisch
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000209:etiology* / Q000503:physiopathology; D006548:Hernia, Diaphragmatic / Q000150:complications; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000254:growth & development*; D008171:Lung Diseases / Q000209:etiology* / Q000503:physiopathology; D008176:Lung Volume Measurements; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors