A case of Vogt-Koyanagi-Harada disease in a patient with Graves disease.
A case of Vogt-Koyanagi-Harada disease (VKH) that developed in a 36-year-old woman with Graves' disease was described. The patient was treated with Lugol's solution and presented with bilateral serous retinal detachment. She had also suffered from methimazole-induced hypersensitivity and steroid-induced myopathy. Fluorescein angiography showed multiple leakage points and a lumbar puncture revealed pleocytosis, which was compatible with VKH. High dose steroid pulse therapy was successful. Altered immune regulation associated with drug-induced hypersensitivity may contribute to the development of VKH in patients with Graves' disease.
Seo
Je Hyun
JH
Department of Ophthalmology, College of Medicine, and Medical Research Center, Seoul National University, Seoul, Korea.
Yu
Hyeong Gon
HG
Chung
Hum
H
D000328:Adult; D004396:Coloring Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000008:administration & dosage; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007275:Injections, Intravenous; D007454:Iodides / Q000008:administration & dosage; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D004396:Coloring Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D007454:Iodides; D009883:Ophthalmic Solutions; C010389:Lugol's solution