Selective immediate hypersensitivity reactions to NSAIDs.
OBJECTIVE
Selective immediate reactions to NSAIDs imply that patients develop a urticarial/anaphylactic response to a single drug with good tolerance to other compounds. No systematic review of these reactions has yet been made.


RESULTS
With the increase in consumption of NSAIDs, these have become one of the most common drugs inducing hypersensitivity reactions. Although cross-intolerance reactions are the most common, a significant proportion is selective responses. As specific IgE antibodies are not always found, there is only indirect evidence supporting an IgE-mediated mechanism in selective NSAID reactors.


CONCLUSIONS
Selective immediate reactions to NSAIDs must be considered when a patient develops urticaria or anaphylaxis after intake of one drug with good tolerance to drugs from other groups or even a drug from the same group with a slightly different chemical structure. Further research is required to identify the antigenic determinant structures recognized.
Canto
Maria Gabriela
MG
Servicio de Alergologia, Hospital Infantal Leonor, Madrid, Spain. mgabriela.canto@salul.madrid.org
Andreu
Isabel
I
Fernandez
Javier
J
Blanca
Miguel
M
D000707:Anaphylaxis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology; D008956:Models, Chemical; D012680:Sensitivity and Specificity; D012882:Skin Tests; D013329:Structure-Activity Relationship; D014581:Urticaria
D000894:Anti-Inflammatory Agents, Non-Steroidal