[Endothelium condition and platelet aggregation in patients with newly diagnosed type 1 diabetes mellitus and undifferentiated connective tissue dysplasia].
The study included 68 patients aged 18-32 years with newly diagnosed type 1 diabetes (DM) and/or undifferentiated connective tissue dysplasia (CTD). Ten healthy subjects without clinical symptoms of CTD served as controls. Induced platelet aggregation, Willebrand factor activity, plasma thromboxane B2, 6-keto-prostaglandin F1a, and endotheline-1 were measured. The results suggest relatively normal functional reserves of endothelium and platelet activity in patients with newly diagnosed DM and compensated carbohydrate metabolism. Elevated vasopressor activity and platelet aggregation in patients with DM and CTD compared with patients without CTD may be one of the mechanisms of angiopathy.
Gladkikh
N N
NN
Iagoda
A V
AV
D000293:Adolescent; D000328:Adult; D003240:Connective Tissue Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000502:physiology*; D055815:Young Adult