[Efficacy of rituximab therapy on diffuse large B-cell lymphoma with different Fcgamma RIIIA gene polymorphisms: a prospective study].
OBJECTIVE
To evaluate the impact of FcgammaRIIIA gene polymorphism on the response to rituximab therapy in newly diagnosed diffuse large B-cell lymphoma (DLBCL).


METHODS
Thirty-four patients with newly diagnosed, histologically proven CD20-positive DLBL received rituximab combined chemotherapy (CHOP regimen) for 6 - 8 courses of 21 days. Peripheral blood samples were collected from these 34 patients and 20 healthy blood donors. PCR was used to detect the FcgammaRIIIA polymorphisms. The initial efficacy was evaluated based on the criteria for non-Hodgkin lymphoma by International Working Group.


RESULTS
The FcgammaRIIIA phenotypes of the 34 patients included VV type (n = 11), FF type (n = 5), and VF type (n = 18). After 6 courses of rituximab treatment combined with chemotherapy, the overall response rate was 79%, and the response rates were 82% and 83% in the VV type and VF type patients respectively, both significantly higher than that in the FF type patients (60%, P = 0.04).


CONCLUSIONS
The most common FcgammaRIIIA polymorphism in DLCL is VF type, followed by VV and FF types. The patients with FcgammaRIIIA VV and VF types are more sensitive to the initial treatment of rituximab combined with chemotherapy compared to the patients with FF type.
Zhang
Wei
W
Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China.
Wang
Xuan
X
Duan
Ming-Hui
MH
Li
Jian
J
Zhou
Dao-Bin
DB
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005838:Genotype; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy* / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D000069283:Rituximab; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; C496124:FCGR3A protein, human; D017452:Receptors, IgG; D000069283:Rituximab