Intracranial infiltration by recurrent scalp dermatofibrosarcoma protuberans.
Dermatofibrosarcoma protuberans (DFSP) of the scalp is a rare soft tissue sarcoma. A 22-year-old male with DFSP, who had undergone several surgical excisions and radiotherapy, presented with a mild left lower-limb paresis. An MRI scan demonstrated a huge mass extending throughout the frontoparietal convexity. A macroscopically complete removal of the mass was performed. Despite this, there were several recurrences; thereafter, the patient underwent surgery, stereotactic radiosurgery and chemotherapy. The histological findings demonstrated a DFSP that both abutted and occasionally invaded the adjacent brain cortex, while extending along the Virchow-Robin spaces. Due to the highly infiltrating characteristics of DFSP, another approach, such as the use of molecular-targeted agents, will be required to significantly improve the clinical outcome.
Abe
Tatsuya
T
Department of Neurosurgery, Oita University School of Medicine, Idaigaoka 1-1, Hasama, Yufu, Oita 879-5593, Japan. abet@med.oita-u.ac.jp
Kamida
Tohru
T
Goda
Makoto
M
Inoue
Ryo
R
Fujiki
Minoru
M
Kobayashi
Hidenori
H
Hatano
Yutaka
Y
Shibuya
Hiromi
H
Fujiwara
Sakuhei
S
Terashi
Hiroto
H
Mori
Teruaki
T
D018223:Dermatofibrosarcoma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods; D012535:Scalp / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D055815:Young Adult