[Hormones and osteoporosis update. Histological aspects on the action of parathyroid hormone (PTH) and PTH-related peptide (PTHrP) on bone and cartilage].
Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) , which were shown to bind the common receptor, PTH/PTHrP receptor, affect fetal chondrogenesis and adult bone turnover, respectively. PTH appears to predominantly stimulate proliferation of osteoblastic precursors, and consequently affect osteoblastic differentiation mediating coupling with osteoclasts. A recent study has reported the biological function of C-terminal region of PTHrP including nucleolar targeting signal. We will review recent reports for the action of PTH and PTHrP on bone and cartilage.
Amizuka
Norio
N
Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine.
Li
Minqi
M
Tamura
Masato
M
Oda
Kimimitsu
K
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002356:Cartilage / Q000196:embryology / Q000378:metabolism*; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D010006:Osteoblasts / Q000166:cytology; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis / Q000187:drug effects; D010281:Parathyroid Hormone / Q000502:physiology*; D044162:Parathyroid Hormone-Related Protein / Q000502:physiology*; D044168:Receptor, Parathyroid Hormone, Type 1 / Q000502:physiology; D013268:Stimulation, Chemical
D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D044168:Receptor, Parathyroid Hormone, Type 1