title: Association of SLC6A9 gene variants with human essential hypertension.
abstract: OBJECTIVE
  We previously identified a quantitative trait locus (QTL) on rat chromosome 5 that appeared to be primarily controlled by the sympathetic nervous system. Because sympathetic overactivity is related to hypertension, solute carrier family 6, member 9 (SLC6A9) is a candidate gene for the connection of this QTL with blood pressure regulation. In the present study, we therefore explored the role of SLC6A9 genetic variations in human essential hypertension (EH).
  
  
  METHODS
  We evaluated three single nucleotide polymorphisms (SNPs) (rs2286245, rs3791124 and rs2486001) in 758 essential hypertension patients and 726 controls. Polymorphism-related genotypes were determined with TaqMan assays.
  
  
  RESULTS
  The allelic frequency of rs2286245 (C versus T, p=0.032) showed significant differences between EH and normotensive controls (NT) groups. The genotypic distribution of rs3791124 in its dominant model (AA+GA versus GG, p=0.027) also showed significant differences between EH and NT groups. The genotype and allele distributions of rs2486001 did not exhibit any significant differences.
  
  
  CONCLUSIONS
  We found an association between SLC6A9 gene polymorphisms and essential hypertension in a Japanese population, suggesting that SLC6A9 is a susceptibility locus for essential hypertension.
authors: Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi 173-8610, Tokyo, Japan. tueno@med.nihon-u.ac.jp
authors: Takahiro
authors: T
authors: Ueno
authors: Yasuharu
authors: Y
authors: Tabara
authors: Noboru
authors: N
authors: Fukuda
authors: Kazunobu
authors: K
authors: Tahira
authors: Taro
authors: T
authors: Matsumoto
authors: Kotoko
authors: K
authors: Kosuge
authors: Akira
authors: A
authors: Haketa
authors: Koichi
authors: K
authors: Matsumoto
authors: Yuichi
authors: Y
authors: Sato
authors: Tomohiro
authors: T
authors: Nakayama
authors: Tomohiro
authors: T
authors: Katsuya
authors: Toshio
authors: T
authors: Ogihara
authors: Yoshio
authors: Y
authors: Makita
authors: Akira
authors: A
authors: Hata
authors: Michiko
authors: M
authors: Yamada
authors: Norio
authors: N
authors: Takahashi
authors: Nobuhito
authors: N
authors: Hirawa
authors: Satosh
authors: S
authors: Umemura
authors: Tetsuro
authors: T
authors: Miki
authors: Masayoshi
authors: M
authors: Soma
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D050487:Glycine Plasma Membrane Transport Proteins / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D050487:Glycine Plasma Membrane Transport Proteins; C493268:SLC6A9 protein, human