title: Electro-acupuncture improves responsiveness to insulin via excitation of somatic afferent fibers in diabetic rats.
abstract: The effects of electro-acupuncture (EA) on plasma concentration of glucose and on responsiveness to insulin were examined in an animal model of diabetes, the streptozotocin-treated rat. Two weeks after treatment with streptozotocin, rats were anesthetized with urethane-chloralose and subjected to the EA for 10 min delivered to the tibialis anterior muscle of one side. The stimulation produced no significant changes in plasma glucose concentration. In contrast, EA increased the response of plasma glucose to insulin (0.2 U kg(-1)). The effect of EA on the responsiveness to insulin was abolished by section of both sciatic and femoral nerves ipsilateral to the side of the EA. These results show that EA in diabetic rats has no effect on plasma glucose concentration while it augments the responsiveness to insulin, and we show that this occurs via a mechanism that involves the somatic afferent nerves.
authors: Center for Medical Science, International University of Health and Welfare, Otawara, Tochigi, Japan.
authors: Yukie
authors: Y
authors: Higashimura
authors: Rie
authors: R
authors: Shimoju
authors: Hitoshi
authors: H
authors: Maruyama
authors: Mieko
authors: M
authors: Kurosawa
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000473:pathology / Q000628:therapy; D004195:Disease Models, Animal; D015671:Electroacupuncture / Q000379:methods*; D005267:Femoral Nerve / Q000293:injuries / Q000502:physiology*; D007839:Functional Laterality; D006614:Hindlimb / Q000294:innervation; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin