Granulomatous slack skin responds to UVA1 phototherapy.
Granulomatous slack skin (GSS) is an extremely rare disorder within the group of cutaneous T cell lymphomas (CTCL). Ultraviolet A1 (UVA1) phototherapy has previously been reported to be useful in the treatment of CTCL such as mycosis fungoides. We report a 35-year-old Caucasian male with GSS treated with UVA1 phototherapy starting at 20 J/cm(2) UVA1 3 times a week and subsequently increased in increments of 5 J/cm(2) to a medium-range dose of 50 J/cm(2) per session. The patient underwent a total of 45 sessions with a cumulative dose of 1,495 J/cm(2) UVA1 without any adverse events. At the conclusion of UVA1 phototherapy, a decrease in erythema and skin thickness was observed which was most prominent in the periphery of the lesion in the right groin area. A follow-up 12 months after phototherapy showed continued treatment benefit. To our knowledge, this is the first report describing the successful use of UVA1 (340-400 nm) phototherapy in a patient with GSS.
Oberholzer
Patrick A
PA
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Cozzio
Antonio
A
Dummer
Reinhard
R
French
Lars E
LE
Hofbauer
Günther F L
GF
D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D014467:Ultraviolet Therapy / Q000379:methods*