Could we prevent unilateral cleft lip/palate in the future?
Surveillance studies have shown that cleft lip and palate is one of the commonest craniofacial anomalies, occurring in approximately 1 in 500 live births. Previous studies on craniofacial form in unilateral cleft lip/palate subjects have been carried out, but most attention has been focused on the deformity of the bony septum whereas the deformities of the nasal spine and cartilaginous component of the septum had received little attention. Our recent study was based on monitoring a very specific type of nasal septal deformity, type 6, and its relation to the unilateral cleft lip/palate disease. This type is very anteriorly located and refers to the cartilaginous part of the nasal septum and the inter-maxillary bone itself. Rhinoscopic view shows a typical, almost horizontal, unilateral groove at the nasal septum located very anteriorly. At the opposite septal side, but corresponding location, there is so called basal crest. The results of our study showed that the incidence of type 6 septal deformity was very high not only in unilateral cleft lip/palate children (80.6%) but also in their parents (58% in at least one of them). In contrast, in our previous study this type of septal deformity was seen in only 3.7% of non-unilateral cleft lip/palate children before puberty, rising to 7.4% in students and 9.4% in adults. In other words, perhaps we can expect the onset of unilateral cleft lip/palate in the offspring of parents who both have a type 6 septal deformity. Perhaps there is a gene responsible for the onset of both type 6 septal deformity and the cleft. If these clinical entities belong to the same gene, the cleft per se could perhaps disappear from the Earth in a near future owing to the gene therapy which will be able to eliminate it before the baby is born or even conceived.
Mladina
Ranko
R
Department of Otolaryngology Head and Neck Surgery, University Hospital Rebro, Zagreb, Croatia.
Skitarelić
Neven B
NB
Skitarelić
Natasa P
NP
D002971:Cleft Lip / Q000235:genetics* / Q000517:prevention & control*; D002972:Cleft Palate / Q000235:genetics* / Q000517:prevention & control*; D005544:Forecasting; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000517:prevention & control; D015316:Genetic Therapy / Q000639:trends*; D006801:Humans; D008957:Models, Genetic