Infusion of hypertonic saline into the lung parenchyma during radiofrequency ablation of the lungs with multitined expandable electrodes: results using a porcine model.
The present study was performed to clarify the effect of hypertonic saline infusion into the lung parenchyma on radiofrequency ablation (RFA) of the lungs. A total of 20 ablation zones were created in 3 pigs. The ablation zones were divided into 3 groups. Group 1 (n=6) consisted of ablation zones created by applying smaller radiofrequency (RF) power without saline infusion; group 2 (n=5) zones were created by applying greater RF power without saline infusion;and group 3 (n=9) zones were created by applying greater RF power with saline infusion. The techniques of saline infusion included administration of hypertonic saline 1 ml before RFA, followed by continuous administration at a rate of 1 ml/min during the first 2 min after the initiation of RFA. The ablation parameters and coagulation necrosis volumes were compared among the groups. Group 3 had a tendency toward smaller mean impedance than group 1 (p=0.059) and group 2 (p=0.053). Group 3 showed significantly longer RF application time than group 2 (p=0.004) and significantly greater maximum RF power than group 1 (p=0.001) and group 2 (p=0.004). Group 3 showed significantly larger coagulation necrosis volume (mean, 1,421mm3) than group 2 (mean, 858 mm3, p=0.039) and had a tendency toward larger necrosis volume than group 1 (mean, 878 mm3, p=0.077). Although this small study had limited statistical power, hypertonic saline infusion during RFA appeared to enlarge coagulation necrosis of the lung parenchyma.
Iishi
Tatsuhiko
T
Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. taiishi@cc.okayama-u.ac.jp
Hiraki
Takao
T
Mimura
Hidefumi
H
Gobara
Hideo
H
Kurose
Taichi
T
Fujiwara
Hiroyasu
H
Sakurai
Jun
J
Yanai
Hiroyuki
H
Yoshino
Tadashi
T
Kanazawa
Susumu
S
D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D004566:Electrodes; D005260:Female; D008168:Lung / Q000033:anatomy & histology / Q000473:pathology / Q000601:surgery*; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D034421:Sus scrofa
D012462:Saline Solution, Hypertonic