title: Effect of lavender oil on motor function and dopamine receptor expression in the olfactory bulb of mice.
abstract: OBJECTIVE
  Although treatment with the essential oil of lavender induces neuroemotional changes, there is a lack of data regarding its specific effects on neurotransduction, especially dopaminergic neurotransduction. We investigated the relationship between altered motor activity and changes in the expression of dopamine receptors (DR), particularly the receptor subtypes D2 and D3, in lavender oil-treated mice.
  
  
  METHODS
  After the administration of lavender oil (intraperitoneal injections of 10-1000 mg/kg lavender oil once per day for 5 days), motor coordination and dopamine receptor expression were examined in the olfactory bulb and the striatum of the mouse brain.
  
  
  RESULTS
  After 5 days, mice treated with 1000 mg/kg lavender oil showed significantly increased rotarod activity when compared to controls. Although DRD2 expression showed no change in the olfactory bulb or striatum of lavender-treated mice, DRD3 expression increased significantly in the olfactory bulb; this increase was dose-dependent and was observed at both the mRNA and protein levels.
  
  
  CONCLUSIONS
  These data indicate that altered dopamine D3 receptor subtype homeostasis in the olfactory bulb may contribute to lavender oil-induced behavioral change.
authors: Department of Public Health, Keimyung University, Taegu 704-701, Republic of Korea.
authors: Younghee
authors: Y
authors: Kim
authors: Minjeong
authors: M
authors: Kim
authors: Hyunji
authors: H
authors: Kim
authors: Kisok
authors: K
authors: Kim
mesh_terms: D000818:Animals; D015153:Blotting, Western; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D027523:Lavandula; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects*; D009822:Oils, Volatile / Q000494:pharmacology*; D009830:Olfactory Bulb / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D010938:Plant Oils / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D009822:Oils, Volatile; D010938:Plant Oils; D012333:RNA, Messenger; D011954:Receptors, Dopamine; D014446:Tyrosine 3-Monooxygenase; C045718:lavender oil