Bone biomarkers and risk of fracture in two- and three-year-old Thoroughbreds.
The aim of this study was to determine whether bone biomarkers (osteocalcin, PICP, ICTP and CTX-I) could be used to identify 2- and 3-year-olds at increased risk of fracture in the subsequent flat racing season. It was concluded that these bone biomarkers cannot be used to identify 2- and 3-year-olds that sustain a fracture. Whether bone biomarkers have better predictive value in older horses or when measured serially in the same animal remains to be determined.
Jackson
B F
BF
Department of Veterinary Clinical Sciences, Hawkshead Lane, Hatfield, Hertfordshire AL9 7TA, UK.
Dyson
P K
PK
Lonnell
C
C
Verheyen
K L P
KL
Pfeiffer
D U
DU
Price
J S
JS
D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001846:Bone Development / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D005260:Female; D050723:Fractures, Bone / Q000097:blood / Q000662:veterinary*; D006734:Horse Diseases / Q000097:blood* / Q000378:metabolism; D006736:Horses; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides; D011347:Procollagen / Q000097:blood; D012307:Risk Factors
D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin; D003094:Collagen