A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code.
Of the 20 amino acids used in proteins, 10 were formed in Miller's atmospheric discharge experiments. The two other major proposed sources of prebiotic amino acid synthesis include formation in hydrothermal vents and delivery to Earth via meteorites. We combine observational and experimental data of amino acid frequencies formed by these diverse mechanisms and show that, regardless of the source, these 10 early amino acids can be ranked in order of decreasing abundance in prebiotic contexts. This order can be predicted by thermodynamics. The relative abundances of the early amino acids were most likely reflected in the composition of the first proteins at the time the genetic code originated. The remaining amino acids were incorporated into proteins after pathways for their biochemical synthesis evolved. This is consistent with theories of the evolution of the genetic code by stepwise addition of new amino acids. These are hints that key aspects of early biochemistry may be universal.
Higgs
Paul G
PG
Origins Institute and Department of Physics and Astronomy, McMaster University, Ontario, Canada. higgsp@mcmaster.ca
Pudritz
Ralph E
RE
D000596:Amino Acids / Q000032:analysis / Q000138:chemical synthesis*; D003062:Codon; D019418:Evolution, Chemical; D019143:Evolution, Molecular; D005815:Genetic Code; D000069497:Origin of Life; D013816:Thermodynamics
D000596:Amino Acids; D003062:Codon