title: Prospective longitudinal comparative study of health-related quality of life in patients treated with radical prostatectomy or permanent brachytherapy for prostate cancer.
abstract: To determine health-related quality of life (HRQOL) after radical retropubic prostatectomy (RRP) or permanent prostate brachytherapy (BT), third party-conducted QOL surveys were prospectively compared. Between 2004 and 2005, 37 patients underwent RRP and 36 were treated with BT. A QOL survey consisting of the Medical Outcomes Study 36-Item Short Form (SF-36), the University of California, Los Angeles, Prostate Cancer Index (UCLA-PCI) and the International Prostate Symptoms Score (IPSS) was completed prospectively by a research coordinator at baseline, and at 1, 3, 6 and 12 months after treatment. The RRP patients scored well in general QOL except at 1 month after surgery, with their mental health better than at baseline by 6 months after surgery. Disease-specific QOL in RRP patients received a low score at 1 month for both urinary and sexual function, though urinary function rapidly recovered to baseline levels. BT patient QOL was not affected by the therapy except in the IPSS score. However, general and mental health scores in BT patients were inferior to those in RRP patients. This prospective study revealed differences in QOL after RRP and BT. These results will be helpful in making treatment decisions.
authors: Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan.
authors: Makoto
authors: M
authors: Kobuke
authors: Takashi
authors: T
authors: Saika
authors: Yoshiko
authors: Y
authors: Nakanishi
authors: Shin
authors: S
authors: Ebara
authors: Daisuke
authors: D
authors: Manabe
authors: Tatsuya
authors: T
authors: Uesugi
authors: Hiroyuki
authors: H
authors: Nose
authors: Ryoji
authors: R
authors: Arata
authors: Tomoyasu
authors: T
authors: Tsushima
authors: Yasutomo
authors: Y
authors: Nasu
authors: Hiromi
authors: H
authors: Kumon
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000523:psychology; D006304:Health Status; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D011468:Prostatectomy / Q000009:adverse effects / Q000523:psychology; D011471:Prostatic Neoplasms / Q000523:psychology / Q000532:radiotherapy / Q000601:surgery; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome