Tandem Blaise-alkenylation with unactivated alkynes: one-pot synthesis of alpha-vinylated beta-enaminoesters from nitriles.
The in situ generated Blaise reaction intermediate, a zinc bromide complex of beta-enaminoester, reacts with various unactivated terminal alkynes and an internal alkyne under mild conditions to afford alpha-vinylated beta-enaminoesters in good to excellent yields.
Chun
Yu Sung
YS
Department of Chemistry and Nano Science (BK21), Ewha Womans University, Seoul 120-750, Korea.
Ko
Young Ok
YO
Shin
Hyunik
H
Lee
Sang-gi
SG
D000480:Alkynes / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry
D000480:Alkynes; D001965:Bromides; D009570:Nitriles; D017967:Zinc Compounds; C093802:zinc bromide