title: CNS and lung metastasis of sebaceous epithelioma in a dog.
abstract: Sebaceous epithelioma is a common canine cutaneous neoplasm characterized by a preponderance of basaloid cells with few well-differentiated sebocytes. It is considered a low-grade malignancy, as it may occasionally recur at the excision site; the possibility of lymph node metastasis is anecdotally reported, and distant metastases have never been observed. This case report presents the clinical and pathological features of a sebaceous epithelioma of the upper lip with a highly aggressive behaviour. The patient was a 9-year-old female dachshund that developed local recurrence 11 months after the excision of the primary sebaceous epithelioma and multiple lung and central nervous system metastases 5 months later. The designation epitheliomatous sebaceous carcinoma has been suggested for aggressive sebaceous epitheliomas, although differential criteria are still to be determined.
authors: Department of Veterinary Public Health and Animal Pathology, Faculty of Veterinary Medicine, University of Bologna, 40064, Ozzano Emilia, Bologna, Italy. giuliano.bettini@unibo.it
authors: Giuliano
authors: G
authors: Bettini
authors: Maria
authors: M
authors: Morini
authors: Luciana
authors: L
authors: Mandrioli
authors: Ombretta
authors: O
authors: Capitani
authors: Gualtiero
authors: G
authors: Gandini
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000556:secondary / Q000662:veterinary*; D002277:Carcinoma / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary*; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*