title: Effects of a diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride concentrations and other cardiovascular risk factors in type 1 diabetes.
abstract: OBJECTIVE
  To compare the effects of a eucaloric diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride (TG) concentrations and other cardiovascular disease risk factors in nonobese subjects with type 1 diabetes and in good glycemic control.
  
  
  METHODS
  In a parallel group design study, 30 subjects were randomly assigned and completed one of the two eucaloric diets. Assessments included: BMI, blood pressure, A1C, plasma lipids, and markers of oxidation, thrombosis, and inflammation. At 6 months, subjects were hospitalized for 24 h to measure plasma TG excursions.
  
  
  RESULTS
  There were no significant differences between groups other than decreased plasminogen activator inhibitor 1 (PAI-1) levels and weight gain in the lower-carbohydrate/higher-monounsaturated fat group. During the 24-h testing, the lower-carbohydrate/higher-monounsaturated fat group had a lower plasma TG profile.
  
  
  CONCLUSIONS
  A diet lower in carbohydrate/higher in monounsaturated fat could offer an appropriate choice for nonobese type 1 diabetic individuals with good metabolic and weight control.
authors: Research Center of the University of Montreal Hospital Center, Montreal, Quebec, Canada. irene.strychar@umontreal.ca
authors: Irene
authors: I
authors: Strychar
authors: Jeffrey S
authors: JS
authors: Cohn
authors: Geneviève
authors: G
authors: Renier
authors: Michèle
authors: M
authors: Rivard
authors: Nahla
authors: N
authors: Aris-Jilwan
authors: Hugues
authors: H
authors: Beauregard
authors: Sara
authors: S
authors: Meltzer
authors: André
authors: A
authors: Bélanger
authors: Richard
authors: R
authors: Dumas
authors: Alain
authors: A
authors: Ishac
authors: Farouk
authors: F
authors: Radwan
authors: Jean-François
authors: JF
authors: Yale
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy*; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D014280:Triglycerides