title: Thermoresponsive, hydrolytically degradable polymer micelles intended for radionuclide delivery.
abstract: Novel polymer micelles, prepared by self-assembling thermoresponsive poly(N-isopropylacrylamide)-graft-poly[N-(2-hydroxypropyl)methacrylamide] copolymers with hydrolytically degradable N-glycosylamine groups between the polymer blocks are proposed for delivery of diagnostic and therapeutic radionuclides into solid tumors. The micelles are formed by fast heating of an aqueous solution of the copolymer to 37 degrees C. They have a hydrodynamic diameter of 128 nm (measured using dynamic light scattering) and slowly degrade during incubation in aqueous buffer at pH = 7.4. Labeling with both (131)I and (90)Y proceeds with high yields (>85%). The unlabeled polymers are not cytotoxic for any of the tested murine and human cell lines.
authors: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague 6, Czech Republic. mhruby@centrum.cz
authors: Martin
authors: M
authors: Hruby
authors: Cestmir
authors: C
authors: Konak
authors: Jan
authors: J
authors: Kucka
authors: Miroslav
authors: M
authors: Vetrik
authors: Sergey K
authors: SK
authors: Filippov
authors: David
authors: D
authors: Vetvicka
authors: Hana
authors: H
authors: Mackova
authors: Goran
authors: G
authors: Karlsson
authors: Katarina
authors: K
authors: Edwards
authors: Blanka
authors: B
authors: Rihova
authors: Karel
authors: K
authors: Ulbrich
mesh_terms: D000178:Acrylamides / Q000737:chemistry / Q000378:metabolism; D000180:Acrylic Resins; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems; D006801:Humans; D006868:Hydrolysis; D008422:Materials Testing; D008823:Micelles; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D011868:Radioisotopes / Q000737:chemistry / Q000378:metabolism*; D013696:Temperature
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D001672:Biocompatible Materials; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D011868:Radioisotopes; C052970:poly-N-isopropylacrylamide; C032976:N-(2-hydroxypropyl)methacrylamide