title: Can we improve fixation and outcomes? Use of bone substitutes.
abstract: Hip fractures secondary to osteoporosis are common in the elderly. Stabilizing these fractures until union is achieved is a challenge due to poor bone stock and insufficient purchase of the implant to the bone. The reported high rate of complications has prompted extensive research in the development of fixation techniques. Furthermore, manipulation of both the local fracture environment in terms of application of growth factors, scaffolds, and mesenchymal cells and the systemic administration of agents promoting bone formation and bone strength has been considered as a treatment option with promising results. There are only a few evidence-based studies reporting on fixation augmentation techniques. This article reports on the efficacy of bone graft substitutes for the fixation of hip fractures, in particular calcium phosphates, which have been used as granules, cements, and implant coatings.
authors: University of Bologna, Rizzoli Orthopaedic Institute, Bologna, Italy. a.moroni@ior.it
authors: Antonio
authors: A
authors: Moroni
authors: Sune
authors: S
authors: Larsson
authors: Amy
authors: A
authors: Hoang Kim
authors: Letizia
authors: L
authors: Gelsomini
authors: Peter V
authors: PV
authors: Giannoudis
mesh_terms: D018786:Bone Substitutes / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D019317:Evidence-Based Medicine; D005265:Femoral Neck Fractures / Q000175:diagnosis* / Q000628:therapy*; D005593:Fracture Fixation, Internal / Q000379:methods* / Q000639:trends*; D006801:Humans
chemical_list: D018786:Bone Substitutes