Time-course expression profiles of hair cycle-associated genes in male mini rats after depilation of telogen-phase hairs.
Jcl:WistarTGN(ARGHGEN)1Nts rat (Mini rat) is a growth hormone (GH)-deficient transgenic rat. The hair cycle in the dorsal skin of male Mini rats enters a long-lasting telogen phase after eights weeks of age, but depilation can induce a transient hair cycle again. In this study, a time-course profiling of genes expression was done on the dorsal skin of male Mini rats along the progression of depilation-induced hair cycle using DNA microarray analysis. As a result, 1,215 probe sets including 1,171 hair cycle-related ones showed more than 3-fold changes in expression compared with that in before-depilation telogen phase. The present data will contribute to elucidating the mechanisms of hair cycle regulation and should lead to the identification of novel molecular targets for hair growth and/or depilation agents.
Umeda-Ikawa
Aya
A
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan.
Shimokawa
Isao
I
Department of Respiratory and Digestive Medicine, Division of Experimental Medicine, Pathology, and Gerontology, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan.
Doi
Kunio
K
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan.|Nippon Institute for Biological Science, 9-2221-1, Shin-Machi, Ome, Tokyo 198-0024, Japan.
D000818:Animals; D015870:Gene Expression; D020869:Gene Expression Profiling; D013006:Growth Hormone / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D006197:Hair / Q000166:cytology / Q000254:growth & development* / Q000502:physiology; D018859:Hair Follicle / Q000196:embryology* / Q000378:metabolism*; D006204:Hair Removal; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D055647:Rats, Transgenic; D017208:Rats, Wistar; D012867:Skin / Q000378:metabolism
D013006:Growth Hormone