Primary sebaceous carcinoma of the corneaoscleral limbus with pagetoid recurrence.
We report a sebaceous carcinoma confined to the corneoscleral limbus without involvement of the eyelid. A 60-year-old man, who showed multiple masses on the corneaoscleral limbus and limbal ulceration but with normal eyelids, underwent surgical en-bloc excision of the masses. Histopathologic examination revealed a sebaceous carcinoma. Three weeks after excision, multiple pagetoid recurrences were found along the bulbar conjunctiva 2 mm away from the limbus. After the application of topical mitomycin C, the pagetoid spread regressed completely. After a 2 year follow-up, no other local or systemic recurrences were observed. This report shows that the ulcerative mass which is confined to only the corneoscleral limbus may be a sebaceous carcinoma even without eyelid involvement. Topical mitomycin C may be effective for treating pagetoid spread of sebaceous carcinoma of limbal origin.
Park
Sang Jun
SJ
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Wee
Won Ryang
WR
Lee
Jin Hak
JH
Kim
Mee Kum
MK
D018266:Adenocarcinoma, Sebaceous / Q000473:pathology* / Q000601:surgery; D001684:Biological Dressings; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D016850:Limbus Corneae / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D013508:Ophthalmologic Surgical Procedures / Q000379:methods; D012626:Sebaceous Gland Neoplasms / Q000473:pathology* / Q000601:surgery