Biochemical infertility among females attending University of Ilorin Teaching Hospital, Nigeria.
BACKGROUND
Biochemical laboratory investigations potentially contribute to the diagnosis of over 50-75% of couples being investigated for infertility. Both hormonal and anti-hormonal treatments have achieved great successes in the treatment of infertility. Our aim therefore was to investigate the pattern of biochemical abnormalities in females diagnosed as infertile form anovulation.


METHODS
One hundred and twenty women diagnosed clinically as primary or secondary infertility from anovulation referred from the gynecological clinic of UITH and private hospitals in Ilorin were investigated by routine fertility test profile.


RESULTS
The age ranged between 20-40 years (mean = 32.9, sd +/- 4.7) for the primary infertility and 23-47 years (mean = 34.4, sd +/- 5.4) for the secondary infertility groups respectively. Ninety six (80%) subjects were found to have hormonal abnormalities. Pattern of biochemical diagnosis amongst the 33 (34.4%) primary infertility subjects included hypergonadotrophic hypogonadism 21 (63.6%), hypogonadotrophic hypogonadism 9 (27.3%), and hyperprolactinemia 3 (9.1%). Among the 63 (65.6%) cases of secondary infertility, there were 31 (49.2%) cases of hypergonadotrophic hypogonadism, 30 (47.6%) hypogonadotrophic hypogonadism, and 2 (3.2%) hyperprolactinemia. There was no statistical difference in the mean values in the various biochemical parameters.


CONCLUSIONS
Hormonal profile should be a goal standard in the diagnosis of anovulation.
Akande
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AA
Department of Chemical Pathology and Immunology, University of Ilorin Teaching Hospital, Ilorin, Nigeria. yinkaakande@yahoo.com
Idowu
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AA
Jimoh
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AK
D000328:Adult; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D006785:Hospitals, University; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications / Q000175:diagnosis; D007006:Hypogonadism / Q000150:complications / Q000175:diagnosis; D007247:Infertility, Female / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D008875:Middle Aged; D009549:Nigeria; D055815:Young Adult
D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary