title: [Effect of lantibiotic warnerin on lipid bilayer membranes].
abstract: The effect of the lantibiotic warnerin on the ionic permeability of artificial membranes has been studied. Membranes were composed of different lipid fractions, including lipids isolated from warnerin-sensitive cells of Staphylococcus epidermidis. It was shown that warnerin selectively interacts with artificial membranes of different lipid composition, which leads, in some cases, to the formation of ionic channels. A computer model of the spatial structure of warnerin has been coustructed, which supports a high probability of the membranotropic activity of this peptide.
authors: M P
authors: MP
authors: Borisova
authors: V P
authors: VP
authors: Korobov
authors: L M
authors: LM
authors: Lemkina
authors: N V
authors: NV
authors: Pan'kova
authors: G N
authors: GN
authors: Likhatskaia
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001430:Bacteriocins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002308:Cardiolipins / Q000737:chemistry; D004553:Electric Conductivity; D007473:Ion Channels / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D008563:Membrane Lipids / Q000737:chemistry; D008958:Models, Molecular; D010713:Phosphatidylcholines / Q000737:chemistry; D011487:Protein Conformation; D013210:Staphylococcus / Q000737:chemistry*; D013212:Staphylococcus epidermidis / Q000737:chemistry / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D002308:Cardiolipins; D007473:Ion Channels; D008051:Lipid Bilayers; D008563:Membrane Lipids; D010713:Phosphatidylcholines; C542625:Warnerin