Efficient access to oseltamivir phosphate (Tamiflu) via the O-trimesylate of shikimic acid ethyl ester.
Karpf
Martin
M
F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Technical Sciences, Synthesis & Process Research, Grenzacherstrasse 124, 4070 Basel, Switzerland. martin.karpf@roche.com
Trussardi
René
R
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry*; D001388:Aziridines / Q000737:chemistry; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D053139:Oseltamivir / Q000138:chemical synthesis / Q000737:chemistry*; D012765:Shikimic Acid / Q000737:chemistry*
D000998:Antiviral Agents; D001388:Aziridines; D053139:Oseltamivir; D012765:Shikimic Acid; C033132:aziridine