title: Righting elicited by novel or familiar auditory or vestibular stimulation in the haloperidol-treated rat: rat posturography as a model to study anticipatory motor control.
abstract: External cues, including familiar music, can release Parkinson's disease patients from catalepsy but the neural basis of the effect is not well understood. In the present study, posturography, the study of posture and its allied reflexes, was used to develop an animal model that could be used to investigate the underlying neural mechanisms of this sound-induced behavioral activation. In the rat, akinetic catalepsy induced by a dopamine D2 receptor antagonist (haloperidol 5mg/kg) can model human catalepsy. Using this model, two experiments examined whether novel versus familiar sound stimuli could interrupt haloperidol-induced catalepsy in the rat. Rats were placed on a variably inclined grid and novel or familiar auditory cues (single key jingle or multiple key jingles) were presented. The dependent variable was movement by the rats to regain equilibrium as assessed with a movement notation score. The sound cues enhanced movements used to regain postural stability and familiar sound stimuli were more effective than unfamiliar sound stimuli. The results are discussed in relation to the idea that nonlemniscal and lemniscal auditory pathways differentially contribute to behavioral activation versus tonotopic processing of sound.
authors: Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada. ccla@ucalgary.ca
authors: Callie A M
authors: CA
authors: Clark
authors: Lori-Ann R
authors: LA
authors: Sacrey
authors: Ian Q
authors: IQ
authors: Whishaw
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000523:psychology; D003463:Cues; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004409:Dyskinesia, Drug-Induced / Q000523:psychology; D006220:Haloperidol / Q000494:pharmacology*; D004856:Postural Balance / Q000187:drug effects / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D014722:Vestibule, Labyrinth / Q000502:physiology; D014741:Video Recording
chemical_list: D018492:Dopamine Antagonists; D006220:Haloperidol