title: Possible role of male factors in recurrent pregnancy loss.
abstract: To evaluate various causes possibly contributing towards recurrent pregnancy loss (RPL), particularly male factors. Prospective study of 75 couples with history of RPL who were investigated for genetic, anatomic, immunological, infective and systemic causes in both partners. Functional sperm capacity was assessed by the Hypo-osmotic swelling test (HOS), Acrosomal Reaction (AR), Nuclear condensation-decondensation test (NCD) and Seminal Total Leukocyte Count (TLC) along with semen analysis. Twenty male volunteers with recently proven fertility were also included for detailed sperm morphology and sperm functions test as controls. Amongst male partners 3 (4%) had varicocele, 23 (30.6%) had infection, 1 (1.3%) immunological and 1 (1.3%) had genetic abnormality. Sperm motility, viability and sperm function tests were significantly lower in the RPL group as compared to the control group (P = 0.000). Male factor might be a possible contributing factor towards RPL. Both the partners should be evaluated and treated simultaneously in order to achieve desirable outcome.
authors: Department of Obstetrics and Gynecology, Lady Hardinge Medical College and Shrimati Sucheta Kriplani Hospital, New Delhi 110 001. pikeesaxena@hotmail.com
authors: Pikee
authors: P
authors: Saxena
authors: M M
authors: MM
authors: Misro
authors: Somnath
authors: S
authors: Roy
authors: K
authors: K
authors: Chopra
authors: D
authors: D
authors: Sinha
authors: Deoki
authors: D
authors: Nandan
authors: Shubha Sagar
authors: SS
authors: Trivedi
mesh_terms: D000026:Abortion, Habitual / Q000503:physiopathology*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D055101:Semen Analysis; D012747:Sexual Partners; D013094:Spermatozoa / Q000473:pathology* / Q000502:physiology*