[Study of serotonin transporter gene polymorphisms in disease of patients with abnormal black Savda].
OBJECTIVE
To explore the association between patients with abnormal black Savda according to Uighur medicine theory and the serotonin transporter (5-HTT) gene polymorphisms in the promoter (5-HTTLPR) and the variable number tandem repeats (VNTRs) in intron 2 (5-HTTVNTR).


METHODS
Divided the patients into four body fluids according to Uighur medicine theory, PCR was used to detect genotype and allele frequencies of 5-HTILPR and 5-HTTVNTR polymorphisms in 66 patients with abnormal black Savda (including 35 cases of hypertension, 19 cases of diabetes, 12 cases of cancer diagnosis) and 45 control subjects.


RESULTS
No significant differences for the genotype frequency or the allele frequency of 5-HTTLPR and 5-HTTVNTR were revealed between patients with abnormal black Savda and control subjects. More control subjects tended to be of L/L genotype (15.56%) than hypertension with abnormal black Savda (5.72%). On the contrary, more cancer diagnosis with abnormal black Savda tended to be of L/L genotype (25.00%) and L (54.17%) allele than control subjects L/L genotype (15.56%) and L allele (37.78%). On the other hand, fewer control subjects tended to be of 10/10 genotype (4.45%) than diabetes with abnormal black Savda (10.53%) and cancer diagnosis with abnormal black Savda (8.34%).


CONCLUSIONS
5-HTTLPR L/L genotype may be a protective factor for hypertension with abnormal black Savda, 5-HTTLPR L/L genotype and L allele may be risk factors for cancer diagnosis with abnormal black Savda, 5-HTTVNTR 10/10 genotype may be risk factors for cancer diagnosis with abnormal black Savda and diabetes with abnormal black Savda.
Dai
Wencheng
W
College of Life Science and Technology, Xinjiang University, Urumqi 830046, China. daiwencheng007@yahoo.com.cn
Renagul
Aziz
A
Hamulati
Wupuer
W
Peng
Xiaomei
X
D000368:Aged; D003920:Diabetes Mellitus / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008519:Medicine, Traditional; D008875:Middle Aged; D018598:Minisatellite Repeats; D009369:Neoplasms / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
D050486:Serotonin Plasma Membrane Transport Proteins