Formulation of intelligent tablets with an antacid effect.
Matrix systems with a local antacid effect were produced in this study. Aluminium hydroxide and magnesium trisilicate in constant concentrations were used as active agents. Eudragit E PO was applied as a matrix former and sodium bicarbonate as a disintegrant (third antacid component), in different ratios. Their effects on the properties of the tablets were studied. Such formulated systems must be insoluble if the pH of the stomach is less acidic, but a rapid disintegration must occur if necessary. It can be concluded that Eudragit E PO in appropriate composition can ensure tablets with pH-dependent disintegration. Its binding effect allows tablet making from the elastic active component. The liberation of antacid materials from this system is controlled. If the pH reached 2.5, the erosion of the tablet was reduced. In contrast with expectations, the application of poorly compressible and effervescent sodium bicarbonate increased the time for disintegration of the tablets, because of its extended alkalizing effect around the tablet. This system with this acrylic component is appropriate to produce a controlled-release local antacid preparation.
Bajdik
János
J
Department of Pharmaceutical Technology, University of Szeged, Szeged H-6720, Hungary.
Korbely
Anita
A
Pintye-Hódi
Klára
K
D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000863:Antacids / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D017633:Magnesium Silicates / Q000008:administration & dosage*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D017693:Sodium Bicarbonate / Q000737:chemistry*; D012995:Solubility; D013607:Tablets / Q000737:chemistry*
D000863:Antacids; D003692:Delayed-Action Preparations; D017633:Magnesium Silicates; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D000536:Aluminum Hydroxide; D017693:Sodium Bicarbonate; C001671:magnesium trisilicate