Antiproliferative bistramides from Trididemnum cyclops from Madagascar (1).
Bioassay-guided fractionation of a marine extract from Trididemnum cyclops afforded the new lipopeptide 39-oxobistramide K (1) and the known bistramides A (2) and D (3). Structure elucidation of 1 was carried out by analysis of one- and two-dimensional NMR spectroscopy and HRMS data. Bistramides have been reported to exhibit antiproliferative activity in the nanomolar range against a number of tumor cell lines in vitro and in vivo. The isolate 1 was tested for antiproliferative activity against the A2780 cell line and exhibited an IC(50) value of 0.34 microM.
Murphy
Brian T
BT
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA.
Cao
Shugeng
S
Brodie
Peggy
P
Maharavo
Jean
J
Andriamanantoanina
Hanta
H
Ravelonandro
Pierre
P
Kingston
David G I
DG
D000081:Acetamides / Q000737:chemistry / Q000302:isolation & purification; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004988:Ethers, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008270:Madagascar; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification; D014561:Urochordata / Q000737:chemistry*
C543771:39-oxobistramide K; D000081:Acetamides; D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D011714:Pyrans; D013141:Spiro Compounds; C059975:bistratene A; C085520:bistramide D