title: Crystal structure of hypothetical protein HP0062 (O24902_HELPY) from Helicobacter pylori at 1.65 A resolution.
abstract: The HP0062 gene encodes a small acidic protein of 86 amino acids with a theoretical pI of 4.6. The crystal structure of hypothetical protein HP0062 from Helicobacter pylori has been determined at 1.65 A by molecular-replacement method. The crystallographic asymmetric unit contains dimer, in which HP0062 monomer folds into a helix-hairpin-helix structure. The two protomers are primarily held together by extensive hydrophobic interactions in an antiparallel arrangement, forming a four helix bundle. Aromatic residues located at a or g position in the heptad leucine zipper are not major contributor required for HP0062 dimerization but important for the thermostability of this protein.
authors: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, San 56-1, Shillim-Dong, Kwanak-Gu, Seoul 151-742, Korea.
authors: Sun-Bok
authors: SB
authors: Jang
authors: Ae-Ran
authors: AR
authors: Kwon
authors: Woo-Sung
authors: WS
authors: Son
authors: Sung Jean
authors: SJ
authors: Park
authors: Bong-Jin
authors: BJ
authors: Lee
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D019281:Dimerization; D016480:Helicobacter pylori / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation; D055550:Protein Stability
chemical_list: D001426:Bacterial Proteins