title: Prognostic factors of liver injury in polytraumatic patients. Results from 895 severe abdominal trauma cases.
abstract: OBJECTIVE
  Prognosis of multiple injured patients is mainly limited by severe haemorrhage. Although mechanisms of altered immune response have been intensively investigated, little is known about the relevance of liver trauma as an independent predictive outcome factor in these patients.
  
  
  METHODS
  10,469 patients from the DGU Trauma Registry (1993-2005) were retrospectively analyzed. Primary admitted patients with an injury severity score > or = 16, without isolated head injury were included. Patients were analyzed according to the injury pattern as liver injury (Abbreviated Injury Scale--AIS abdomen < 3 and AIS liver 2-5; n = 321), non-liver abdominal trauma (AIS abdomen 2-5 or AIS liver < 3; n = 574) and control group without abdominal injuries (AIS abdomen or liver < 3; n = 9,574).
  
  
  RESULTS
  Severe liver injury was associated with excessive demands for volume resuscitation and induced a significantly increased risk for sepsis and multi-organ failure (MOF) compared to both other groups (sepsis 19.9% vs. 11.0%; MOF 32.7% vs. 16.6%). Furthermore, deleterious outcome was more frequently associated with severe liver trauma (mortality 34.9%) compared to severe abdominal trauma (12.0%).
  
  
  CONCLUSIONS
  Severe liver trauma is an independent predictor for severe haemorrhage with a substantially increased risk of sepsis, MOF and trauma-related death. While conservative treatment of patients with liver trauma but no haemorrhage is effective, patients with hemodynamic instability seem to be from a subgroup where contemporary treatment modalities are not yet sufficient.
authors: Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Germany.
authors: Matthias
authors: M
authors: Heuer
authors: Georg
authors: G
authors: Taeger
authors: Gernot M
authors: GM
authors: Kaiser
authors: Dieter
authors: D
authors: Nast-Kolb
authors: Christian A
authors: CA
authors: Kuehne
authors: Steffen
authors: S
authors: Ruchholtz
authors: Rolf
authors: R
authors: Lefering
authors: Andreas
authors: A
authors: Paul
authors: Sven
authors: S
authors: Lendemans
mesh_terms: D000007:Abdominal Injuries / Q000150:complications* / Q000401:mortality / Q000628:therapy; D000328:Adult; D001803:Blood Transfusion / Q000706:statistics & numerical data; D005260:Female; D005858:Germany / Q000453:epidemiology; D006470:Hemorrhage / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D006801:Humans; D008099:Liver / Q000293:injuries*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000150:complications* / Q000401:mortality / Q000628:therapy; D055815:Young Adult