Treatment responses in antiretroviral treatment-naive premenopausal and postmenopausal HIV-1-infected women: an analysis from AIDS Clinical Trials Group Studies.
Menopause may affect antiretroviral treatment (ART) response. Immunologic and virologic responses to ART were compared in 220 premenopausal and 47 postmenopausal women enrolled in 2 studies involving ART-naive persons. Changes in CD4 counts or human immunodeficiency virus type 1 RNA levels were similar at 24, 48, and 96 weeks after treatment initiation. ART-naive women should respond to ART regardless of menopausal status.
Patterson
Kristine B
KB
University of North Carolina, Chapel Hill, NC 27599-7215, USA. kristine_patterson@med.unc.edu
Cohn
Susan E
SE
Uyanik
Jennifer
J
Hughes
Michael
M
Smurzynski
Marlene
M
Eron
Joseph J
JJ
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D018791:CD4 Lymphocyte Count; D005260:Female; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D016896:Treatment Outcome; D014481:United States; D019562:Viral Load