title: Progress toward the total synthesis of psymberin/irciniastatin A.
abstract: In this paper, we describe our synthesis of four key building blocks for the total synthesis of psymberin (1) and its C4 epimer (2). Despite early difficulties in processing material to the advanced intermediate stage, we have been successful in developing high-yielding syntheses for the pyran core, natural side chain, 4-epi side chain, and aryl fragments of the molecule. Our findings from the optimization process are presented herein.
authors: Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, USA.
authors: Lauren E
authors: LE
authors: Brown
authors: Yakira R
authors: YR
authors: Landaverry
authors: James R
authors: JR
authors: Davies
authors: Kristin A
authors: KA
authors: Milinkevich
authors: Sandra
authors: S
authors: Ast
authors: Joseph S
authors: JS
authors: Carlson
authors: Allen G
authors: AG
authors: Oliver
authors: Joseph P
authors: JP
authors: Konopelski
mesh_terms: D003374:Coumarins; D008968:Molecular Conformation; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D011753:Pyrones; C498383:psymberin