Norepinephrine and cardiovascular responses to maximal exercise in Parkinson's disease on and off medication.
The aim of this experiment is to understand how Parkinson's disease (PD) medication affects the autonomic responses of individuals during an acute exercise stress test. Fourteen people with PD and fifteen healthy individuals age-matched between 50 and 80 years performed a modified Bruce protocol. Subjects with PD performed the test once off medication (PD-off) and then 1 week later on medication (PD-on). Heart rate (HR), blood pressure (BP), VO(2), and norepinephrine (NE) levels were taken at rest and at peak exercise. At peak exercise HR, BP, and NE values for the PD-on and PD-off group were all significantly lower than healthy controls, regardless of whether subjects were on their medication. Autonomic abnormalities during exercise in this population appear to be disease manifested and not impacted by medications used to treat PD. We can assume, both on and off medication, this population will show markedly lower BP, HR, and NE responses.
DiFrancisco-Donoghue
Joanne
J
Academic Health Care Center, New York College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, USA. jdonoghu@nyit.edu
Elokda
Ahmed
A
Lamberg
Eric M
EM
Bono
Nancy
N
Werner
William G
WG
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D016022:Case-Control Studies; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D018709:Statistics, Nonparametric
D009638:Norepinephrine