title: Subintimal angioplasty: meta-analytical evidence of clinical utility.
abstract: OBJECTIVE
  The aim of this study was to determine accurate estimates of the success rate of subintimal angioplasty in terms of ability to recanalise occluded vessels, patency over time and limb salvage rates.
  
  
  METHODS
  A meta-analysis of published literature.
  
  
  METHODS
  All studies reporting unique patient data published in English language between 1989 and 2008.
  
  
  METHODS
  Separate meta-analyses were performed for immediate technical success, 12-month patency rates and 12-month limb salvage rates. Longer-term outcomes were analyzed in separate meta-analyses. Meta-regression was applied to determine whether any of these outcomes had improved over time.
  
  
  RESULTS
  Pooled estimates for technical success, primary patency at 12 months and limb salvage at 12 months were 85.7% (95% confidence interval: 83.3%-87.7%, 2810 limbs), 55.8% (95% confidence interval: 47.9%-63.4%, 1342 limbs), and 89.3% (95% confidence interval: 85.5%-92.2%, 2810 limbs), respectively. Regression analysis demonstrated no significant change in outcomes over time. There was some evidence of publication bias, however, after adjusting for this there was little change in the pooled outcome estimates.
  
  
  CONCLUSIONS
  This study demonstrates that the outcomes for subintimal angioplasty are good and that this method should be considered as an alternative to surgical bypass.
authors: Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. m.bown@le.ac.uk
authors: M J
authors: MJ
authors: Bown
authors: A
authors: A
authors: Bolia
authors: A J
authors: AJ
authors: Sutton
mesh_terms: D017130:Angioplasty / Q000009:adverse effects / Q000379:methods*; D003251:Constriction, Pathologic; D005121:Extremities / Q000098:blood supply*; D006801:Humans; D023821:Limb Salvage; D016491:Peripheral Vascular Diseases / Q000503:physiopathology / Q000601:surgery*; D017594:Publication Bias; D012044:Regression Analysis; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency