Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers.
Chemoprevention of lung carcinogenesis is one approach to controlling the epidemic of lung cancer caused by cigarette smoking. The target for chemoprevention should be the activities of the multiple carcinogens, toxicants, co-carcinogens, tumour promoters and inflammatory compounds in cigarette smoke. At present there are many agents, both synthetic and naturally occurring, that prevent lung tumour development in well-established animal models. It seems likely that logically constructed mixtures of these agents, developed from the ground up, will be necessary for the prevention of lung carcinogenesis.
Hecht
Stephen S
SS
Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street South East, Minneapolis, Minnesota 55455, USA. hecht002@umn.edu
Kassie
Fekadu
F
Hatsukami
Dorothy K
DK
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D019819:Budesonide / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003545:Cysteine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007294:Inositol / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000209:etiology / Q000517:prevention & control*; D012907:Smoking / Q000009:adverse effects*; D013859:Thiocarbamates / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; C465294:N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine; D013859:Thiocarbamates; D007294:Inositol; D019819:Budesonide; D003545:Cysteine