Delivery of bioactive conjugated linoleic acid with self-assembled amylose-CLA complex.
A delivery system for bioactive conjugated linoleic acid (CLA) through a self-assembled amylose-CLA complex was investigated in comparison with a beta-cyclodextrin (BCD)-CLA complex. Successful complexation between CLA and amylose or BCD was confirmed by differential scanning calorimetry, X-ray diffraction, and Fourier transform infrared spectral analysis. The yield and complexing percentages were 71.9 and 1.4% for the amylose-CLA complex and 42.3 and 7.7% for the BCD-CLA complex, respectively. However, the amylose-CLA complex showed a better antioxidative protection effect on CLA than BCD-CLA complex, supporting a strong complexing interaction between CLA and amylose shown by thermogravimetric analysis. Compared to 15.9% of CLA released from the BCD-CLA complex under simulated small intestine conditions, 95.6% of CLA was released from the amylose-CLA complex. These results indicate that an amylose-lipid complex self-assembled in the natural way of food component interaction can be used to protect and deliver functional lipids or other bioactive components into the targeted small intestine for absorption.
Yang
Ying
Y
School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China.
Gu
Zhengbiao
Z
Zhang
Genyi
G
D000688:Amylose / Q000737:chemistry*; D001682:Biological Availability; D016503:Drug Delivery Systems / Q000379:methods*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism; D044243:Linoleic Acids, Conjugated / Q000737:chemistry / Q000493:pharmacokinetics*; D008954:Models, Biological; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry
D044243:Linoleic Acids, Conjugated; D047392:beta-Cyclodextrins; D000688:Amylose