title: IgM monoclonal component associated with type I Gaucher disease resolved after enzyme replacement therapy: a case report.
abstract: The frequency of monoclonal gammopathy of undetermined significance (MGUS) is higher in patients with type I Gaucher disease (GD I) than in the general population. Although enzyme replacement therapy is effective in the control of the disease, its effect on MGUS is still controversial. We present the case of a 65-year-old woman with extensive GD I associated with IgM MGUS, in whom enzyme replacement therapy succeeded in eradicating the monoclonal component. This observation further supports the idea that enzyme replacement therapy decreases the chronic antigenic stimulation responsible for gammopathies in Gaucher disease.
authors: Hematology and Clinical Oncology Unit, Hospital Universitario J.M. Morales Meseguer, Marqués de los Vélez s/n, 30008, Murcia, Spain.
authors: C
authors: C
authors: Martinez-Redondo
authors: F J
authors: FJ
authors: Ortuño
authors: M L
authors: ML
authors: Lozano
authors: A
authors: A
authors: Jerez
authors: M
authors: M
authors: del Mar Osma
authors: P
authors: P
authors: Giraldo
authors: V
authors: V
authors: Vicente
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000097:blood; D056947:Enzyme Replacement Therapy; D005260:Female; D005776:Gaucher Disease / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D005962:Glucosylceramidase / Q000097:blood / Q000235:genetics / Q000627:therapeutic use*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000209:etiology* / Q000276:immunology*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D011994:Recombinant Proteins; D005962:Glucosylceramidase; C090568:imiglucerase