title: Rifampin-associated pseudomembranous colitis.
abstract: Pseudomembranous colitis (PMC) is known to develop after antibiotic treatment, but is rarely associated with antituberculosis (anti-TB) agents. We report a 28-year-old woman without underlying diseases developing PMC after 126 days of anti-TB treatment. Severe diarrhea and abdominal cramping pain were experienced. Colonoscopic biopsy proved the diagnosis of PMC. Her symptoms improved after discontinuing the anti-TB agents but recurred shortly after challenging with rifampin and isoniazid. Metronidazole administration and replacement of rifampin with levofloxacin successfully cured the PMC. Our report supports the notion that rifampin can induce PMC.
authors: Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan.
authors: Tun-Chieh
authors: TC
authors: Chen
authors: Po-Liang
authors: PL
authors: Lu
authors: Wei-Ru
authors: WR
authors: Lin
authors: Chun-Yu
authors: CY
authors: Lin
authors: Jeng-Yih
authors: JY
authors: Wu
authors: Yen-Hsu
authors: YH
authors: Chen
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D016360:Clostridioides difficile / Q000187:drug effects; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D012293:Rifampin / Q000009:adverse effects*
chemical_list: D000995:Antitubercular Agents; D012293:Rifampin