title: Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism.
abstract: BACKGROUND
  Infantile hepatic hemangioma with consumptive hypothyroidism is a rare condition.
  
  
  METHODS
  A 4-month-old girl presented with diffuse hepatic hemangiomas during treatment of congenital hypothyroidism. Serum reverse triiodothyronine was elevated, and her hypothyroidism improved concomitant with involution of the hemangioma following prednisolone and interferon-alpha administration. At 20 months of age, 7 months after discontinuing prednisolone and interferon-alpha, a focal hemangioma regrew from one of the previous lesions and was surgically resected. The expression and activity of type 3 iodothyronine deiodinase (D3) were elevated in the resected tumor tissue compared with placenta.
  
  
  CONCLUSIONS
  Here, we describe a patient with consumptive hypothyroidism and diffuse infantile hepatic hemangiomas, one of which regrew after involution following pharmacotherapy. The etiology of elevated D3 activity is also discussed.
  
  
  CONCLUSIONS
  It is important to identify infantile hepatic hemangioma in patients with hypothyroidism refractory to hormone replacement therapy, who have low free triiodothyronine despite high thyrotropin and normal free thyroxine levels, and long-term follow-up will be needed for these patients.
authors: Department of Pediatrics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Kazuhiko
authors: K
authors: Bessho
authors: Yuri
authors: Y
authors: Etani
authors: Hiroaki
authors: H
authors: Ichimori
authors: Yoko
authors: Y
authors: Miyoshi
authors: Noriyuki
authors: N
authors: Namba
authors: Akihiro
authors: A
authors: Yoneda
authors: Takaharu
authors: T
authors: Ooue
authors: Tsuyoshi
authors: T
authors: Chihara
authors: Eiichi
authors: E
authors: Morii
authors: Tomoyuki
authors: T
authors: Aoki
authors: Masami
authors: M
authors: Murakami
authors: Sotaro
authors: S
authors: Mushiake
authors: Keiichi
authors: K
authors: Ozono
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006391:Hemangioma / Q000150:complications / Q000175:diagnosis / Q000201:enzymology*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000201:enzymology; D007223:Infant; D007453:Iodide Peroxidase / Q000235:genetics / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis / Q000201:enzymology*; D008279:Magnetic Resonance Imaging; D016133:Polymerase Chain Reaction; D012334:RNA, Neoplasm / Q000235:genetics; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D012334:RNA, Neoplasm; C117274:iodothyronine deiodinase type III; D007453:Iodide Peroxidase