[Interrelation between the glycogen content in hepatocytes and their size in normal and cirrhotic rat liver].
The dependence between the size of hepatocytes and glycogen content in them was investigated in normal and cirrhotic liver from fasting rats as well as from rats in 10 and 60 minutes after per os glucose administration. The cytophotometric method used allows glycogen and DNA contents determining in the same cell and its dry mass as well. It has been shown that the dry mass and the glycogen content in hepatocytes from normal and cirrhotic liver are proportional to genes dose. Normal liver hepatocytes of various ploidy classes show distinct correlation between the cell size and the glycogen content. No similar dependence is observed in hepatocytes population from the cirrhotic liver, apparently, because the liver lobule structure is disturbed, and heterogeneity of the hepatocytes microenvironment condition is increased.
Bezborodkina
N N
NN
Vakhtina
A A
AA
Baĭdiuk
E V
EV
Iakupova
G S
GS
Kudriavtsev
B N
BN
D000818:Animals; D048429:Cell Size; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism* / Q000473:pathology*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism* / Q000473:pathology*; D008112:Liver Glycogen / Q000032:analysis / Q000378:metabolism*; D008297:Male; D011003:Ploidies; D051381:Rats
D008112:Liver Glycogen; D005947:Glucose