Vascular dysfunction in the diabetic placenta: causes and consequences.
The development and functioning of the human fetoplacental vascular system are vulnerable to the maternal diabetic milieu. These vessels are in direct continuum with the fetal vascular system and are therefore also vulnerable to fetal endocrine derangements. Increased angiogenesis, altered junctional maturity and molecular occupancy, together with increased leakiness, constitute a well-described phenotype of vessels in the Type 1 diabetic human placenta and can be related to increased levels of placental vascular endothelial growth factor. The causes of these observed changes, whether maternal hyperglycaemia or fetal hyperinsulinaemia, still remain to be shown in the human placenta. Mechanistic studies using different vascular systems have shown high glucose and insulin to have profound vascular effects, with elevations in vascular endothelial growth factor, nitric oxide and protein kinase C being behind alterations in junctional adhesion molecules such as occludin and vascular endothelial-cadherin and vascular leakage of albumin. The role of advanced glycation products and oxidative stress in this vascular pathology is also discussed. The altered molecular mechanisms underlying the vascular changes in the diabetic human placenta may reflect similar consequences of high glucose and hyperinsulinaemia.
Leach
Lopa
L
School of Biomedical Sciences, Centre for Integrated Systems Biology and Medicine, Institute of Clinical Research, Faculty of Medicine and Health Sciences, University of Nottingham, UK. lopa.leach@nottingham.ac.uk
Taylor
Alice
A
Sciota
Flavia
F
D002199:Capillary Permeability / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology; D006946:Hyperinsulinism / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*