title: Total synthesis of cyathin A(3) and cyathin B(2).
abstract: A stereoselective synthesis of cyathin A(3) and cyathin B(2) has been achieved by a Prins-type reaction of a cycloalkenyl cyclopropanol. Particularly noteworthy is the use of a spirocyclobutanone moiety as a convenient scaffold for an efficient ring-closing metathesis to stereoselectively construct a suitably functionalized seven-membered ring (see scheme).
authors: Department of Chemistry, Wayne State University, Detroit, MI 48236, USA.
authors: Keunho
authors: K
authors: Kim
authors: Jin Kun
authors: JK
authors: Cha
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D055365:Cyathus / Q000737:chemistry*; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; C007179:cyathins