title: Recent developments in the chemistry of thebaine and its transformation products as pharmacological targets.
abstract: The most practical synthetic routes to the preparation of as important pharmaceuticals as oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid, thebaine, as a starting material. This review intends to focus on chemical transformations of morphinans which resulted in morphinandiene derivatives with well-established and novel pharmacological potencies. These chemical transformations were mainly associated with the formation and substitution of the unique diene structure of the ring C of the morphinan backbone.
authors: Department of Organic Chemistry, University of Debrecen, Debrecen, Hungary.
authors: Sándor
authors: S
authors: Berényi
authors: Csaba
authors: C
authors: Csutorás
authors: Attila
authors: A
authors: Sipos
mesh_terms: D000818:Animals; D006801:Humans; D015394:Molecular Structure; D013237:Stereoisomerism; D013797:Thebaine / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D013797:Thebaine