title: A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug.
abstract: Isotretinoin is a known human teratogen that can cause multiple malformations. At present, women who conceive one cycle after discontinuing isotretinoin are told that their teratogenic risk is not higher than baseline. We present a case of both-ear malformation in a newborn whose mother had taken isotretinoin for 2 years until one month prior to the time when she became pregnant. We suggest that further studies of pharmacokinetics and malformation of isotretinoin are needed.
authors: Department of Pediatrics, Yonsei University College of Medicine, 250 Seongsan-ro, Seodaemun-gu,Seoul, Korea.
authors: Soon Min
authors: SM
authors: Lee
authors: He Min
authors: HM
authors: Kim
authors: Jun Seok
authors: JS
authors: Lee
authors: Choon Sik
authors: CS
authors: Yoon
authors: Min Soo
authors: MS
authors: Park
authors: Kook In
authors: KI
authors: Park
authors: Ran
authors: R
authors: Namgung
authors: Chul
authors: C
authors: Lee
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015474:Isotretinoin / Q000009:adverse effects*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D015474:Isotretinoin