Primary adenosquamous carcinoma of the colon: report of five cases.
Primary adenosquamous cell carcinomas (Ad-SCCs) of the colon and rectum are rare malignancies with a poor prognosis, in comparison to adenocarcinoma alone. Different roles of human papilloma virus (HPV) in its pathogenesis have been reported and the role of P16 in Ad-SCCs has not been explored. This report presents five cases of Ad-SCC of the colon to explore the clinicopathological features and the roles of P16, HPV 6/11, and 16/18. There was no confirmed evidence to support the relationship between the infection of HPV 6/11, 16/18, and pathogenesis of Ad-SCC of the colon. P16 overexpression was not related to HPV carcinogenesis and there might be another mechanism of P16 upregulation in Ad-SCC of the colon.
Dong
Yingchun
Y
Department of Anesthesiology, Medical School of Nanjing University, Nanjing Stomatology Hospital, Nanjing, PR China.
Wang
Jiandong
J
Ma
Henghui
H
Zhou
Hangbo
H
Lu
Guangming
G
Zhou
Xiaojun
X
D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000302:isolation & purification*; D018196:Carcinoma, Adenosquamous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery / Q000821:virology*; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery / Q000821:virology*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005260:Female; D052140:Human papillomavirus 11 / Q000302:isolation & purification; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000302:isolation & purification; D052163:Human papillomavirus 6 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology*; D011379:Prognosis
C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D009363:Neoplasm Proteins