Ironing out a midlife crisis.
There is a strong correlation between age, genomic instability, and the development of cancer. Working in yeast, Veatch et al. (2009) now propose that defects in the biogenesis of iron-sulfur clusters arising as a consequence of mitochondrial dysfunction contribute to the increase in genomic instability as cells age.
Vergara
Sandra Viviana
SV
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. sandra.vergara@duke.edu
Thiele
Dennis J
DJ
D016922:Cellular Senescence; D042822:Genomic Instability; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007506:Iron-Sulfur Proteins / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000502:physiology*
D007506:Iron-Sulfur Proteins; D007501:Iron