Early translation of adipose-derived cell therapy for cardiovascular disease.
Over the past decade, cell therapy has emerged as a new approach to reversing myocardial ischemia. Several types of adult stem cells have been studied in both preclinical and clinical conditions for this purpose: bone marrow cells, circulating cells, and myoblasts. Nevertheless, the quest for the ideal "anti-ischemic" cell is still ongoing. Recently, the existence of a population of stem cells located in adipose tissue (adipose-derived stem cells) has been observed. These are able to differentiate into multiple cell lineages including cardiomyocytic differentiation. In this review we discuss the basic principles of adipose-derived stem cells (types and characteristics, harvesting, and expansion), the initial experimental studies, and the currently ongoing clinical trials.
Sanz-Ruiz
Ricardo
R
Cardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Fernández-Santos
Eugenia
E
Domínguez-Muñoa
Marta
M
Parma
Radoslaw
R
Villa
Adolfo
A
Fernández
Lucía
L
Sánchez
Pedro L
PL
Fernández-Avilés
Francisco
F
D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D035843:Biomedical Research; D002318:Cardiovascular Diseases / Q000473:pathology* / Q000628:therapy*; D015510:Clinical Medicine; D006801:Humans; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology