Antiplasmodial isoflavanones from the roots of Sophora mollis.
Six new prenylated isoflavanones named sophoronols A-F (1-6), together with eight phenolic constituents, were isolated from the roots of Sophora mollis. Their structures and stereochemistry were established by 1D and 2D NMR techniques, especially HMBC and NOESY as well as CD results. Componds 3 and 5 exhibited moderate anitplasmodial activity against the CQS D10 strain of Plasmodium falciparum, with IC(50) values of 12.9 and 12.8 microM, respectively.
Zhang
Gui-Ping
GP
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
Xiao
Zhi-Yong
ZY
Rafique
Jamal
J
Arfan
Mohammad
M
Smith
Peter J
PJ
Lategan
Carmen A
CA
Hu
Li-Hong
LH
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan; D021261:Parasitic Sensitivity Tests; D018517:Plant Roots; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D029909:Sophora / Q000737:chemistry*
D000962:Antimalarials; D007529:Isoflavones; C065753:isoflavanone