Breast cancer SRC activity: bad to the bone.
Bone metastases are a major cause of breast cancer morbidity and mortality. In this issue of Cancer Cell, Zhang and colleagues identify a Src activation expression signature associated with late-onset breast cancer bone metastases and provide evidence for Src as a key mediator of survival signals in latent bone metastases.
Sgroi
Dennis C
DC
Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA. dsgroi@partners.org
D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary*; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000473:pathology*; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000378:metabolism*
D016392:Proto-Oncogene Proteins pp60(c-src)