Two new unprecedented acetonyl-bearing sesquiterpenes from the hainan sponge Dysidea fragilis.
Two new acetonyl-bearing sesquiterpenes, dysifragilisins A and B (1 and 2, resp.), have been isolated from the Hainan marine sponge Dysidea fragilis. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analyses and by comparison of their NMR data with those of structurally related compounds. A plausible biogenetic pathway is proposed for the origin of compounds 1 and 2.
Yu
Zhi-Guo
ZG
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zu Chong Zhi Rd. 555, Shanghai 201203, P. R. China.
Li
Jia
J
Li
Zhen-Yu
ZY
Guo
Yue-Wei
YW
D000818:Animals; D047088:Dysidea / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D012717:Sesquiterpenes; C543337:dysifragilisin A; C543338:dysifragilisin B; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1