title: Edema of the photoreceptor layer in Vogt-Koyanagi-Harada disease observed using high-resolution optical coherence tomography.
abstract: OBJECTIVE
  To evaluate the characteristics of fluid accumulation in the uveitic stage of Vogt-Koyanagi-Harada (VKH) disease using high resolution optical coherence tomography (OCT3).
  
  
  METHODS
  Twenty-eight eyes in 14 patients with VKH disease were reviewed retrospectively. These 28 eyes were divided into 19 eyes with intraretinal fluid (C group) and 9 eyes without intraretinal fluid (N group). Changes in visual acuity and fluid accumulation observed using OCT were compared between the two groups.
  
  
  RESULTS
  Visual acuity at the time of presentation was significantly worse in the C group than in the N group (p=0.005). The photoreceptor layer appeared to be double-layered due to a cystoid space in the C group. Layered structures and strands found in the cystoid space. Expanding sponge-form edema led to the development of a cystoid space in the photoreceptor layer. Intraretinal fluid resolved earlier than subretinal fluid. There were no observed differences in visual acuity between the two groups after four days of treatment.
  
  
  CONCLUSIONS
  Accumulation of intraretinal fluid was related to poor initial visual acuity, but not to final visual acuity. High resolution OCT findings indicate that edema of the photoreceptor layer participates in the development of a cystoid space.
authors: Department of Ophthalmology, School of Medicine, Pusan National University, Busan, Korea.
authors: Ji Eun
authors: JE
authors: Lee
authors: Seung Who
authors: SW
authors: Park
authors: Ja Kyun
authors: JK
authors: Lee
authors: Hee Young
authors: HY
authors: Choi
authors: Boo Sup
authors: BS
authors: Oum
authors: Hyun Woong
authors: HW
authors: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement; D008269:Macular Edema / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000473:pathology; D055815:Young Adult