title: Early administration of thrombolysis can prevent myocardial necrosis: time is myocardium.
abstract: A case is presented in which a 66-year-old man received thrombolysis for an acute ST elevation myocardial infarction (STEMI) within 6 minutes of developing chest pain. An ECG performed 10 minutes after thrombolysis showed complete resolution of the ST segment elevation and showed no other abnormality. An echocardiogram showed normal left ventricular function and there was no detectable myocardial necrosis, as evidenced by two negative troponin assays. The case clearly reinforces the benefits of the rapid delivery of thrombolysis when appropriate for patients with STEMI. Clinicians need to be aware of the benefits of early thrombolysis as laid out in the national service framework. Evidence for the early administration of thrombolysis, data from the Myocardial Infarction National Audit Project and the future with regard to improving thrombolysis times are discussed.
authors: Department of Cardiology, Royal Surrey County Hospital, Guildford, UK. mrajaysuri@hotmail.com
authors: A
authors: A
authors: Suri
authors: S
authors: S
authors: Ahsan
authors: J
authors: J
authors: Lim
authors: T-P
authors: TP
authors: Cusack
authors: T P
authors: TP
authors: Chua
authors: E W
authors: EW
authors: Leatham
mesh_terms: D000368:Aged; D004562:Electrocardiography; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis / Q000517:prevention & control; D000077785:Tenecteplase; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator; D000077785:Tenecteplase