title: Multimodality bronchoscopic [corrected] imaging of tracheopathica osteochondroplastica.
abstract: Results of a commercial optical coherence tomography system used as part of a multimodality diagnostic bronchoscopy platform are presented for a 61-year-old patient with central airway obstruction from tracheopathica osteochondroplastica. Comparison to results of white-light bronchoscopy, histology, and endobronchial ultrasound examination are accompanied by a discussion of resolution, penetration depth, contrast, and field of view of these imaging modalities. White-light bronchoscopy revealed irregularly shaped, firm submucosal nodules along cartilaginous structures of the anterior and lateral walls of the trachea, sparing the muscular posterior membrane. Endobronchial ultrasound showed a hyperechoic density of 0.4 cm thickness. optical coherence tomography (OCT) was performed using a commercially available, compact time-domain OCT system (Niris System, Imalux Corp., Cleveland, Ohio) with a magnetically actuating probe (two-dimensional, front imaging, and inside actuation). Images showed epithelium, upper submucosa, and osseous submucosal nodule layers corresponding with histopathology. To our knowledge, this is the first time these commercially available systems are used as part of a multimodality bronchoscopy platform to study diagnostic imaging of a benign disease causing central airway obstruction. Further studies are needed to optimize these systems for pulmonary applications and to determine how new-generation imaging modalities will be integrated into a multimodality bronchoscopy platform.
authors: University of California School of Medicine, Pulmonary and Critical Care Medicine, Department of Medicine, 101 the City Drive South, Building 53, Room 119, Route 81 Orange, California 92868, USA. hcolt@uci.edu
authors: Henri
authors: H
authors: Colt
authors: Septimiu D
authors: SD
authors: Murgu
authors: Yeh-Chan
authors: YC
authors: Ahn
authors: Matt
authors: M
authors: Brenner
mesh_terms: D001999:Bronchoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014133:Tracheal Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography / Q000379:methods*