title: The effect of a hypertension self-management intervention on diabetes and cholesterol control.
abstract: BACKGROUND
  Most patient chronic disease self-management interventions target single-disease outcomes. We evaluated the effect of a tailored hypertension self-management intervention on the unintended targets of glycosylated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C).
  
  
  METHODS
  We evaluated patients from the Veterans Study to Improve the Control of Hypertension, a 2-year randomized controlled trial. Patients received either a hypertension self-management intervention delivered by a nurse over the telephone or usual care. Although the study focused on hypertension self-management, we compared changes in HbA1c among a subgroup of 216 patients with diabetes and LDL-C among 528 patients with measurements during the study period. Changes in these laboratory values over time were compared between the 2 treatment groups using linear mixed-effects models.
  
  
  RESULTS
  For the patients with diabetes, the hypertension self-management intervention resulted in a 0.46% reduction in HbA1c over 2 years compared with usual care (95% confidence interval, 0.04%-0.89%; P = .03). For LDL-C, there was a minimal 0.9 mg/dL between-group difference that was not statistically significant (95% confidence interval, -7.3-5.6 mg/dL; P = .79).
  
  
  CONCLUSIONS
  There was a significant effect of the self-management intervention on the unintended target of HbA1c, but not LDL-C. Chronic disease self-management interventions might have "spill-over" effects on patients' comorbid chronic conditions.
authors: Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC 27705, USA. power017@mc.duke.edu
authors: Benjamin J
authors: BJ
authors: Powers
authors: Maren K
authors: MK
authors: Olsen
authors: Eugene Z
authors: EZ
authors: Oddone
authors: Hayden B
authors: HB
authors: Bosworth
mesh_terms: D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood*; D003920:Diabetes Mellitus / Q000628:therapy; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012648:Self Care; D017216:Telemedicine
chemical_list: D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human