Breast-like vulvar lesion with concurrent breast cancer: a case report and critical literature review.
In the current report, we describe an intriguing case of a breast-like cancer lesion located in the vulvar region in a woman lacking a remarkable past medical or family history of breast cancer but with concurrent breast cancer. Consequently, a differential diagnosis between a primary synchronous breast and vulvar cancer or a metastatic breast carcinoma to the vulva is a key point in terms of the clinical approach. In a review of the literature, 39 cases of breast-like cancer lesion have been described: 23 cases of primary infiltrating carcinoma of the vulva and 16 cases of vulvar metastases of breast carcinoma. To the best of our knowledge, this is the first report of a clinically synchronous vulvar metastasis from an invasive ductal carcinoma. The main diagnostic criteria for differential diagnosis between primary or metastatic breast-like vulvar carcinoma are also discussed.
Perrone
Giuseppe
G
Department of Anatomical Pathology, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 200, 00128 Roma, Italy. g.perrone@unicampus.it
Altomare
Vittorio
V
Zagami
Mariagiovanna
M
Vulcano
Ettore
E
Muzii
Ludovico
L
Battista
Cleonice
C
Rabitti
Carla
C
Muda
Andrea Onetti
AO
D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D044584:Carcinoma, Ductal / Q000556:secondary*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D014846:Vulvar Neoplasms / Q000556:secondary*