title: Two siblings with progressive, fluctuating hearing loss after head trauma, treated with cochlear implantation.
abstract: OBJECTIVE
  Description of two siblings with unexplained, progressive, perceptive hearing loss after head trauma.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Two siblings aged six and eight years old with bilateral, intermittent but progressive hearing loss.
  
  
  RESULTS
  These patients had a c.1172G>A (p.Ser391Asn) mutation in the SLC26A4 gene, which has not previously been reported and which caused Pendred or enlarged vestibular aqueduct syndrome. The diagnosis was based on the perceptive hearing loss, computed tomography findings and mutation analysis. The patients were each fitted with a cochlear implant because of their severe, progressive, perceptive hearing loss with deep fluctuations. The results were good.
  
  
  CONCLUSIONS
  Further testing for the presence of an enlarged vestibular aqueduct is recommended when children present with sudden progression in perceptive hearing loss, whether or not in combination with head trauma. Cochlear implantation is indicated in patients with persistent, progressive hearing loss that leads to deafness. Implantation can be undertaken successfully despite cochlear hypoplasia.
authors: Department of Otorhinolaryngology, Donders Centre of Neuroscience, The Netherlands. m.dewolf@kno.umcn.nl
authors: M J F
authors: MJ
authors: de Wolf
authors: J
authors: J
authors: Honings
authors: F B M
authors: FB
authors: Joosten
authors: L
authors: L
authors: Hoefsloot
authors: E A M
authors: EA
authors: Mylanus
authors: C W R J
authors: CW
authors: Cremers
mesh_terms: D002648:Child; D019929:Cochlear Implantation; D006259:Craniocerebral Trauma / Q000150:complications*; D004252:DNA Mutational Analysis; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology* / Q000601:surgery; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics; D020125:Mutation, Missense; D000076988:Sulfate Transporters; D013577:Syndrome; D014057:Tomography, X-Ray Computed
chemical_list: D026901:Membrane Transport Proteins; C085609:SLC26A4 protein, human; D000076988:Sulfate Transporters