title: The wonderful apparatus of John Jacob Abel called the "artificial kidney".
abstract: Hemodialysis, which now provides life-saving therapy to millions of individuals, began as an exploratory attempt to sustain the lives of selected patients in the 1950s. That was a century after the formulation of the concept and determination of the laws governing dialysis. The first step in the translation of the laboratory principles of dialysis to living animals was the "vividiffusion" apparatus developed by John Jacob Abel (1859-1938), dubbed the "artificial kidney" in the August 11, 1913 issue of The Times of London reporting the demonstration of vividiffusion by Abel at University College. The detailed article in the January 18, 1914 of the New York Times, reproduced here, is based on the subsequent medical reports published by Abel et al. Tentative attempts of human dialysis in the decade that followed based on the vividiffusion apparatus of Abel and his materials (collodion, hirudin, and glass) met with failure and had to be abandoned. Practical dialysis became possible in the 1940s and thereafter after cellophane, heparin, and teflon became available. Abel worked in an age of great progress and experimental work in the basic sciences that laid the foundations of science-driven medicine. It was a "Heroic Age of Medicine," when medical discoveries and communicating them to the public were assuming increasing importance. This article provides the cultural, social, scientific, and medical background in which Abel worked, developed and reported his wonderful apparatus called the "artificial kidney."
authors: Renal Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-3498, USA. geknoyan@bcm.edu
authors: Garabed
authors: G
authors: Eknoyan
mesh_terms: D004867:Equipment Design / Q000266:history; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D007676:Kidney Failure, Chronic / Q000266:history / Q000628:therapy; D007688:Kidneys, Artificial / Q000266:history*; D006435:Renal Dialysis / Q000266:history* / Q000295:instrumentation; D014481:United States