Children's toxicology from bench to bed--Drug-induced renal injury (3): Drug transporters and toxic nephropathy in childhood.
The kidney is susceptible to drugs and environmental substances because of its anatomical and functional reasons, one of which is the existence of drug transport systems in proximal tubular cells. Among those, Organic anion transporter family (OAT family) plays the central role in elimination of drugs from the kidney and development of nephrotoxicity. Regarding drug nephrotoxicity in children, development of the child and the kidney should also be taken into account. This review focuses on the mechanisms of toxic nephropathy in children with special attention to the OAT family.
Sekine
Takashi
T
Department of Pediatrics, Gradate School of Medicine, The University of Tokyo, Japan. sekinet-tky@umin.ac.jp
Endou
Hitoshi
H
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D027362:Organic Anion Transport Protein 1 / Q000378:metabolism / Q000502:physiology; D027361:Organic Anion Transporters / Q000378:metabolism / Q000502:physiology*; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D027362:Organic Anion Transport Protein 1; D027361:Organic Anion Transporters; D004364:Pharmaceutical Preparations