A novel synthesis of 1,3-oxazine-2,4-diones via a simple and efficient reaction of CO2 with 2,3-allenamides.
A simple and efficient reaction of CO(2) with 2,3-allenamides under mild conditions (CO(2) balloon without any metal catalyst in the presence of K(2)CO(3) or Cs(2)CO(3)) leads to an efficient synthesis of 1,3-oxazine-2,4-diones. The high reactivity of the allene moiety is crucial for the success of this transformation since the corresponding reaction of alpha,beta-unsaturated alkenamides or alkynamides does not occur.
Chen
Guofei
G
Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, PR China.
Fu
Chunling
C
Ma
Shengming
S