Towards transgenic primates: What can we learn from mouse genetics?
Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.
KUANG
Hui
H
Brain and Behavior Discovery Institute, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA.
WANG
Phillip L
PL
TSIEN
Joe Z
JZ
D000818:Animals; D030801:Animals, Genetically Modified; D055786:Gene Knockout Techniques; D006801:Humans; D051379:Mice / Q000235:genetics*; D011323:Primates / Q000235:genetics*; D019076:Transgenes