title: [Three-dimensional numerical simulation and hemodynamic analysis of intracranial longitypical aneurysms].
abstract: OBJECTIVE
  To establish a model of three-dimensional numerical simulation of intracranial longitypical aneurism and analyze the hemodynamic features thereof.
  
  
  METHODS
  Ten patients with intracranial longitypical aneurism underwent surgical treatment. Intracranial vascular ultrasonography was conducted before operation. Intra-operatively three-dimensional angiography of the aneurysm was conducted and multifunctional physiological monitor was used to record the dynamic pressure and pressure wave form of the main branch parent artery. Matlab, Ansys, and Fluent software were used to simulate the blood flow of the longitypical aneurysms.
  
  
  RESULTS
  The hemodynamic parameter levels were the highest at the inflow tract, followed by those at the outflow tract, and were the lowest at the top of aneurysm, for example, the blood flow velocity was (1.07+/-0.23) m/s, the dynamic pressure was (574+/-186) Pa, and the wall shear stress was (7.7+/-2.0) Pa at the inflow tract, all significantly higher than those at the top [(0.15+/-0.07) m/s, (37+/-13) Pa, and (0.40+/-0.13) Pa respectively, all P<0.05]. No eddy or just simple eddy occurred in the aneurysm.
  
  
  CONCLUSIONS
  The dynamic pressure, velocity, and wall shear stress are the lowest at the top of longitypical aneurysm which may contribute to the rupture of aneurysm.
authors: Department of Neuroradiosugery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Beijing 100050, China. msq1216@163.com
authors: Shi-qing
authors: SQ
authors: Mu
authors: Xin-jian
authors: XJ
authors: Yang
authors: Ying
authors: Y
authors: Zhang
authors: Bin
authors: B
authors: Luo
authors: Ming
authors: M
authors: Lü
authors: Zhong-xue
authors: ZX
authors: Wu
authors: Hai-yun
authors: HY
authors: Li
authors: Sheng-zhang
authors: SZ
authors: Wang
authors: Guang-hong
authors: GH
authors: Ding
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002533:Cerebral Angiography; D003198:Computer Simulation; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D012984:Software