First trimester PTX3 levels in women who subsequently develop preeclampsia and fetal growth restriction.
Pentraxin 3 (PTX3) and C-reactive protein (CRP) levels were measured in the first trimester of pregnancy in women who subsequently developed preeclampsia (PE, n=16) and fetal growth restriction (FGR, n=12) requiring iatrogenic delivery before 37 weeks, and those who had uncomplicated pregnancies delivering at term (n=60). Mean PTX3 levels were significantly higher in women who subsequently developed PE (7.31 ng/ml, SD = 4.12) when compared to those with normal pregnancy outcome (4.92 ng/ml, SD = 1.94, p=0.0046). There were no significant differences between PTX3 levels in women with FGR (4.82 ng/ml, SD = 2.35) compared to normal pregnancy outcome (p=0.88). The median CRP levels did not vary significantly between the three groups (p=0.26). PTX3 levels in women who subsequently develop PE are already elevated in the first trimester, but not in those that develop FGR. This supports the hypothesis of an excessive maternal inflammatory response to pregnancy in the etiology of PE.
Cetin
Irene
I
Unit of Obstetrics and Gynecology I, Department of Clinical Sciences Luigi Sacco, University of Milan, Italy.
Cozzi
Veronica
V
Papageorghiou
Aris T
AT
Maina
Virginia
V
Montanelli
Alessandro
A
Garlanda
Cecilia
C
Thilaganathan
Basky
B
D000328:Adult; D000704:Analysis of Variance; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D006801:Humans; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D012307:Risk Factors; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D018709:Statistics, Nonparametric; D000099153:Pentraxins
D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins