[Potential of anidulafungin in combined therapy].
Combined, simultaneous or sequential antifungal therapy has often been considered an appropriate option to improve the results obtained with monotherapy. Anidulafungin belongs to the echinocandin family, which has a different mechanism of action from the remaining antifungal agents, a characteristic that heralds a good chance of synergy with other groups. However, most of the data available on the efficacy of different combinations comes from animal models of infection, "in vitro" data and case reports, while data from controlled clinical trials are scarce. The available data are insufficient to allow us to conclude that the efficacy of combined therapy is significantly superior to that of monotherapy. However, the efficacy of combined therapy may be adequate for the treatment of severe invasive mycoses associated with high mortality rates, such as forms of aspergillosis that provoke central nervous system involvement, extensive pulmonary involvement, cavitated areas, or respiratory failure and infections caused by multiresistant fungi.
Gadea
Ignacio
I
Departamento de Microbiología, Fundación Jiménez Díaz-UTE, Madrid, España. igadea@tjd.es
Mensa
José
J
D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001393:Azoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004679:Encephalomyelitis / Q000188:drug therapy; D016469:Fungemia / Q000188:drug therapy; D006168:Guinea Pigs; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy; D051379:Mice; D009181:Mycoses / Q000188:drug therapy*
D000935:Antifungal Agents; D001393:Azoles; D054714:Echinocandins; D000666:Amphotericin B; D000077612:Anidulafungin