Cortistatin vaccination--a solution to growth hormone deficiency.
Cortistatin and somatostatin are neuropeptides which have inhibitory effects on growth hormone through common five receptors. Although, both have inhibitory effects but, only cortistatin has direct inhibitory effects on growth hormone secretagogue and is more potent inhibitor of growth hormone than somatostatin. This control of growth hormone can be manipulated through immunoneutralization of cortistatin through cortistatin DNA vaccine rather than antibodies application. A DNA vaccine of cortistatin can be produced using recombinant DNA technology in a eukaryotic expression system and will serve as a tool not to only alleviate the growth hormone deficiency problems in human but, can also be used to improve growth rate in farm animals.
Moaeen-ud-Din
M
M
Functional Genomics Lab, University of Veterinary and Animal Sciences, Lahore, Pakistan. drmoinawan79@yahoo.com
Malik
Nosheen
N
Guo
Yang Li
YL
Ali
Ahmad
A
Babar
Masroor Ellahi
ME
D006130:Growth Disorders / Q000628:therapy*; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D009479:Neuropeptides / Q000008:administration & dosage* / Q000627:therapeutic use
D009479:Neuropeptides; C099323:cortistatin; D013006:Growth Hormone