title: Stereocontrolled routes to beta,beta'-disubstituted alpha-amino acids.
abstract: Owing to their significant abundance in natural products, chiral beta,beta'-disubstituted alpha-amino acids remain an important synthetic objective. Emphasis has been focused in this critical review on the great diversity of enantio- and diastereoselective methodologies to reach these highly functionalized compounds. The oldest and cutting edge synthetic methods are described in parallel with the synthesis of many relevant biologically active targets (224 references).
authors: Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
authors: Julien
authors: J
authors: Michaux
authors: Gilles
authors: G
authors: Niel
authors: Jean-Marc
authors: JM
authors: Campagne
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry; D001388:Aziridines / Q000138:chemical synthesis / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D001384:Azetidines; D001388:Aziridines; D007097:Imines; D005998:Glycine