title: pH-sensitive intracellular photoluminescence of carbon nanotube-fluorescein conjugates in human ovarian cancer cells.
abstract: To add to the understanding of the properties of functionalized carbon nanotubes in biological applications, we report a monotonic pH sensitivity of the intracellular fluorescence emission of single-walled carbon nanotube-fluorescein carbazide (SWCNT-FC) conjugates in human ovarian cancer cells. Light-stimulated intracellular hydrolysis of the amide linkage and localized intracellular pH changes are proposed as mechanisms. SWCNT-FC conjugates may serve as intracellular pH sensors.
authors: Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, USA.
authors: M T
authors: MT
authors: Chen
authors: L M
authors: LM
authors: Gomez
authors: F N
authors: FN
authors: Ishikawa
authors: P T
authors: PT
authors: Vernier
authors: C
authors: C
authors: Zhou
authors: M A
authors: MA
authors: Gundersen
mesh_terms: D045744:Cell Line, Tumor; D005260:Female; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D042541:Intracellular Space / Q000378:metabolism*; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000378:metabolism; D013059:Spectrum Analysis, Raman
chemical_list: D005456:Fluorescent Dyes; D037742:Nanotubes, Carbon; D016650:Fluorescein-5-isothiocyanate