title: Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies.
abstract: Diffuse optical methods were used to monitor two different therapies in K1735 malignant mouse melanoma tumor models: anti-vascular therapy and radiation therapy. Anti-vascular therapy induced acute variation in hemodynamic parameters within an hour, and radiation therapy induced longitudinal changes within 2 weeks. During anti-vascular therapy, the drug Combretastatin A-4 3-O-Phosphate (CA4P, 2.5 mg/200 mul PBS/mouse) significantly decreased tissue blood flow (65%) and blood oxygenation (38%) one hour after injection. In the longitudinal study, single-fraction ionizing radiation (12 Gy x 1) induced significant reduction of tissue blood flow (36%) and blood oxygenation (24%) 14 days after radiation. The results correlated well with contrast enhanced ultrasound, tumor histology, and a nitroimidazole hypoxia marker (EF5). The research provides further evidence that noninvasive diffuse optical spectroscopies can be useful tools for monitoring cancer therapy in vivo.
authors: Ulas
authors: U
authors: Sunar
authors: Sosina
authors: S
authors: Makonnen
authors: Chao
authors: C
authors: Zhou
authors: Turgut
authors: T
authors: Durduran
authors: Guoqiang
authors: G
authors: Yu
authors: Hsing-Wen
authors: HW
authors: Wang
authors: William M
authors: WM
authors: Lee
authors: Arjun G
authors: AG
authors: Yodh