[Surgical treatment for primary gastrointestinal stromal tumors: a report of 73 cases].
OBJECTIVE
To investigate the effects and prognosis of surgical treatment in primary gastrointestinal stromal tumors (GIST).


METHODS
The clinicopathological data of 73 patients with primary GIST underwent operation from April 1997 to December 2007 was retrospectively analyzed, and the prognosis was evaluated too.


RESULTS
Among the 73 cases, 68 cases received complete tumor resection, among which 12 cases underwent laparoscopic operation; while palliative resection and biopsy only were carried out in the other 5 cases. There was significant difference in survival rate between the two groups (P = 0.000). The 1-, 3-, 5-year survival rates of the 66 cases had been followed up was 91.0%, 78.2% and 74.1%, respectively. The malignancy risk grades of GIST was related to the survival rates on statistical analysis (P = 0.002). Significant differences were found in the survival rates between the patients with very low grade, low grade and high grade malignancy tumors (P = 0.012, 0.002).


CONCLUSIONS
Complete tumor resection should be emphasized in primary GIST, and more attention should be paid to the initial surgical treatment. Extended surgical resection is required for tumors of higher malignancy risk. The indications of laparoscopic surgery in GIST should be selected with caution for tumor complete resection.
Zhang
Wei
W
Department of General Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Shao
Qin-shu
QS
Ye
Zai-yuan
ZY
Zhao
Zhong-sheng
ZS
Wang
Yue-dong
YD
Zhu
Yang-wen
YW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis