Plasma visfatin concentrations in subjects with type 1 diabetes mellitus.
OBJECTIVE
Visfatin is a recently discovered adipokine, and its circulating concentrations have not been adequately studied in type 1 diabetes mellitus (DM). Therefore, this study was designed to examine plasma visfatin levels in type 1 diabetic patients and to determine the relationships between visfatin and duration of diabetes, body mass index, glycemic control, insulin dosage and lipid profile.


METHODS
Forty-eight patients with type 1 DM and 26 healthy controls were investigated.


RESULTS
Type 1 diabetic patients had significantly low visfatin levels compared with controls (18.8 +/- 1.7 vs. 20.2 +/- 0.3 ng/ml; p < 0.0001). Visfatin levels were comparable between patients with a short duration of diabetes (<10 years) and patients with a long duration of diabetes (>or=10 years) (18.9 +/- 1.7 vs. 18.2 +/- 2.0 ng/ml; p > 0.05). There was a significant correlation between visfatin and hemoglobin A1c (HbA1c) even after the adjustment for age, sex, body mass index and duration of diabetes (r = -0.48, p = 0.005) in the patient group. Multivariate analysis showed that significant determinants of visfatin concentrations were HbA1c and duration of diabetes (r(2) = 0.27).


CONCLUSIONS
These data emphasize that plasma visfatin concentrations are lower in patients with type 1 DM and related to glycemic control reflected by HbA1c.
Toruner
F
F
Division of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Altinova
A E
AE
Bukan
N
N
Arslan
E
E
Akbay
E
E
Ersoy
R
R
Arslan
M
M
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008055:Lipids; D054409:Nicotinamide Phosphoribosyltransferase