title: High b-value apparent diffusion-weighted images from CURVE-ball DTI.
abstract: OBJECTIVE
  To investigate the utility of a proposed clinical diffusion imaging scheme for rapidly generating multiple b-value diffusion contrast in brain magnetic resonance imaging (MRI) with high signal-to-noise ratio (SNR).
  
  
  METHODS
  Our strategy for efficient image acquisition relies on the invariance property of the diffusion tensor eigenvectors to b-value. A simple addition to the conventional diffusion tensor MR imaging (DTI) data acquisition scheme used for tractography yields diffusion-weighted images at twice and three times the conventional b-value. An example from a neurosurgical brain tumor is shown. Apparent diffusion-weighted (ADW) images were calculated for b-values 800, 1600, and 2400 s/mm(2), and a map of excess diffusive kurtosis was computed from the three ADWs.
  
  
  RESULTS
  High b-value ADW images demonstrated decreased contrast between normal gray and white matter, while the heterogeneity and contrast of the lesion was emphasized relative to conventional b-value data. Kurtosis maps indicated the deviation from Gaussian diffusive behavior.
  
  
  CONCLUSIONS
  DTI data with multiple b-values and good SNR can be acquired in clinically reasonable times. High b-value ADW images show increased contrast and add information to conventional DWI. Ambiguity in conventional b-value images over whether hyperintense signal results from abnormally low diffusion, or abnormally long T(2), is better resolved in high b-value images.
authors: Radiology Department, Brigham and Women's Hospital, Boston, Massachusetts, USA. speled@bwh.harvard.edu
authors: Sharon
authors: S
authors: Peled
authors: Stephen
authors: S
authors: Whalen
authors: Ferenc A
authors: FA
authors: Jolesz
authors: Alexandra J
authors: AJ
authors: Golby
mesh_terms: D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000473:pathology