title: Immunohistochemical expression of matrilysins (MMP-7 and MMP-26) in ameloblastomas and adenomatoid odontogenic tumors.
abstract: OBJECTIVE
  The aim was to evaluate the expression of matrix metalloproteinases (MMPs) 7 and 26 in ameloblastomas and adenomatoid odontogenic tumors (AOTs).
  
  
  METHODS
  Twenty intraosseous solid ameloblastomas and 10 intraosseous AOTs were evaluated regarding immunohistochemical expression of MMP-7 and -26 in the epithelium and stroma.
  
  
  RESULTS
  There was no statistically significant difference in MMP-7 and -26 expression between the epithelium of ameloblastomas (P = .50) and AOTs (P = .90). Stromal staining for MMP-7 was evident in all cases. For MMP-26, stromal staining was observed in 65% of ameloblastomas and 50% of AOTs, and this difference was not statistically significant (P = .69).
  
  
  CONCLUSIONS
  The marked expression of these matrilysins suggests their role in the process of tissue remodeling and growth in the studied tumors, but it does not relate to the their distinct patterns of aggressiveness.
authors: Oral Pathology Graduate Program, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil.
authors: Valéria
authors: V
authors: Souza Freitas
authors: Cristina Ruan
authors: CR
authors: Ferreira de Araújo
authors: Pollianna Muniz
authors: PM
authors: Alves
authors: Lélia Batista
authors: LB
authors: de Souza
authors: Hébel Cavalcanti
authors: HC
authors: Galvão
authors: Roseana
authors: R
authors: de Almeida Freitas
mesh_terms: D000564:Ameloblastoma / Q000201:enzymology*; D003238:Connective Tissue / Q000201:enzymology; D042783:Endothelial Cells / Q000201:enzymology; D004847:Epithelial Cells / Q000201:enzymology; D004848:Epithelium / Q000201:enzymology; D005347:Fibroblasts / Q000201:enzymology; D006801:Humans; D007150:Immunohistochemistry; D020783:Matrix Metalloproteinase 7 / Q000032:analysis*; D053505:Matrix Metalloproteinases, Secreted / Q000032:analysis*; D009808:Odontogenic Tumors / Q000201:enzymology*
chemical_list: C410599:MMP26 protein, human; D053505:Matrix Metalloproteinases, Secreted; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7