title: MR prediction of postnatal outcomes in left-sided congenital diaphragmatic hernia using right lung signal intensity: comparison with that using right lung volume.
abstract: OBJECTIVE
  To investigate the validity of the fetal right lung-to-liver signal intensity ratio (LLSIR) for prediction of postnatal outcomes in left-sided congenital diaphragmatic hernia (CDH) MATERIALS AND METHODS: The study included 14 pregnant women who underwent MR exams for evaluation of fetal left-sided CDH. The fetuses were divided into two groups: Group A (n = 9), alive, and Group B (n = 5), dead. On the basis of the half-Fourier acquisition single-shot turbo spin-echo sequence, LLSIR and the right fetal lung volume (FLV) was calculated. In the control group, a regression analysis was performed to associate LLSIR and right FLV with gestational age. The relative LLSIR and right FLV (the observed/expected LLSIR and right FLV) were compared between Groups A and B.
  
  
  RESULTS
  The mean relative LLSIR, as well as the mean relative right FLV, of Group A was significantly higher than that of Group B (p = 0.035). Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for the relative LLSIR and the relative right FLV, when the cutoff point was defined as 0.646 and 0.420, were the same and were 88.9%, 80.0%, 88.9%, 80.0%, and 85.7%, respectively.
  
  
  CONCLUSIONS
  The postnatal outcomes in left-sided CDH may be predicted using the LLSIR.
authors: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan. anishie@radiol.med.kyushu-u.ac.jp
authors: Akihiro
authors: A
authors: Nishie
authors: Tsuyoshi
authors: T
authors: Tajima
authors: Yoshiki
authors: Y
authors: Asayama
authors: Kousei
authors: K
authors: Ishigami
authors: Masakazu
authors: M
authors: Hirakawa
authors: Tomohiro
authors: T
authors: Nakayama
authors: Yasuhiro
authors: Y
authors: Ushijima
authors: Daisuke
authors: D
authors: Kakihara
authors: Daisuke
authors: D
authors: Okamoto
authors: Takashi
authors: T
authors: Yoshiura
authors: Kouji
authors: K
authors: Masumoto
authors: Tomoaki
authors: T
authors: Taguchi
authors: Kiyomi
authors: K
authors: Tsukimori
authors: Shoji
authors: S
authors: Tokunaga
authors: Hiroyuki
authors: H
authors: Irie
authors: Kengo
authors: K
authors: Yoshimitsu
authors: Hiroshi
authors: H
authors: Honda
mesh_terms: D000328:Adult; D005260:Female; D005313:Fetal Death; D006548:Hernia, Diaphragmatic / Q000401:mortality / Q000473:pathology*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D008168:Lung / Q000473:pathology*; D008176:Lung Volume Measurements / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015588:Observer Variation; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis / Q000379:methods* / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016019:Survival Analysis