title: A prognostic scoring system for adult patients less than 60 years of age with acute lymphoblastic leukemia in first relapse.
abstract: The outcome of patients with acute lymphoblastic leukemia (ALL) in first relapse is poor. We retrospectively evaluated patients with ALL in first relapse, 18-60 years of age, to define a prognostic score. For all patients, a scoring system of 0-3 was developed with 1 point for each of the following: age at diagnosis >or=45 years, lactate dehydrogenase (LDH) at the time of relapse >or=1.5 times upper limits of normal (ULN), not proceeding to allogeneic bone marrow transplant (BMT). A similar scoring system was developed for patients proceeding to BMT. LDH >or=1.5 times ULN at the time of relapse predicted poor overall survival. Patients with a prognostic score of greater than 1 have a poor prognosis, even with BMT, and should be considered for treatment with innovative approaches such as Phase 1 clinical trials.
authors: Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH 44195, USA. advania@ccf.org
authors: Anjali
authors: A
authors: Advani
authors: Tao
authors: T
authors: Jin
authors: Brian
authors: B
authors: Bolwell
authors: Edward
authors: E
authors: Copelan
authors: Mikkael
authors: M
authors: Sekeres
authors: Ronald
authors: R
authors: Sobecks
authors: Shawnda
authors: S
authors: Sungren
authors: Melissa
authors: M
authors: Yurch
authors: Matt
authors: M
authors: Kalaycio
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology; D009367:Neoplasm Staging / Q000379:methods; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy*; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D007770:L-Lactate Dehydrogenase