[The expression of aromatase P450 in the mammary gland of hypertrophic breast].
OBJECTIVE
To investigate the expression of aromatase P450 in the mammary gland of hypertrophic breast.


METHODS
The expression of aromatase P450 in the mammary gland was detected by SP immunohistochemistry in 28 cases of hypertrophic breasts and 12 cases of normal volume breasts. The results were analysed by SPSS 13.0, and comparison among groups was performed by Fisher's exact test.


RESULTS
The positive expression rate of aromatase P450 in hypertrophic group was 39.29%, while there was no positive expression in normal group, showing a significant difference between the two groups (P < 0.05). There was no significant difference between the gland hyperplasia group and adipose hyperplasia group (P > 0.05). There were also no significant difference between the groups with different lactation history or different extent of hypertrophy and mastocytosis (P > 0.05).


CONCLUSIONS
Overexpression of aromatase P450 in mammary gland may be related to the development of hypertrophic breast.
Zhang
Yong
Y
Department of Plastic Surgery, Union Hospital of Tongji Medical College, Huazhong Science and Technology University, Wuhan 430022, China.
Sun
Jia-ming
JM
D000293:Adolescent; D000328:Adult; D001141:Aromatase / Q000096:biosynthesis*; D001941:Breast Diseases / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D042361:Mammary Glands, Human / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
D001141:Aromatase