title: [The use of recombinant activated factor VII to control haemorrhage following exenteration and massive transfusion in coagulopathic patients].
abstract: BACKGROUND
  Exentheresis pelvis totalis due to locally advanced pelvic malignancies is an extensive surgical procedure. The operation is commonly associated with anticipated perioperative haemorrhage requiring a large volume of haemoproducts. Sometimes, the intervention can result in unexpected massive and uncontrolled haemorrhage that is frequently a combination of surgical and coagulopathic bleeding. Attempts to arrest massive bleeding by conventional means may fail.
  
  
  METHODS
  We describe our experience in the use of recombinant activated factor VII (rFVIIa) in three previously hemostatically competent patients who underwent exentheresis in order to control massive bleeding resulting from dilution coagulopathy in the operating theatre, as well as in the treatment of postoperative bleeding associated with consumptive coagulopathy. Of these, two massively transfused patients developed dilution coagulopathy in the operative theatre, which was poorly responsive to conventional management. In both cases, a single dose of rFVIIa (70 microg/kg and 60 microg/kg respectively) was given. Prompt clinical response was achieved and operations were successfully finished. In the third case, the patient developed consumptive coagulopathy on the first day after surgical procedure that was treated with conventional therapy. On the second postoperative day the patient became anuric and experienced severe intraabdominal bleeding. The bleeding was successfully controlled with rFVIIa in a single dose of 70 microg/kg.
  
  
  CONCLUSIONS
  RFVIIa can be a treatment option in patients suffering from intractable coagulopathic bleeding when standard therapy has failed.
authors: Dragica
authors: D
authors: Vucelić
authors: Dragutin
authors: D
authors: Kecmanović
authors: Maja
authors: M
authors: Pavlov
authors: Vitomir
authors: V
authors: Ranković
authors: Vesna
authors: V
authors: Masirević
authors: Alma
authors: A
authors: Djukić
authors: Ivan
authors: I
authors: Palibrk
authors: Ljubica
authors: L
authors: Tomasević
authors: Jelena
authors: J
authors: Velicković
authors: Aleksandra
authors: A
authors: Milovanović
mesh_terms: D000368:Aged; D001778:Blood Coagulation Disorders / Q000188:drug therapy* / Q000209:etiology; D016063:Blood Loss, Surgical; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010385:Pelvic Exenteration / Q000009:adverse effects*; D019106:Postoperative Hemorrhage / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D065227:Transfusion Reaction
chemical_list: D006490:Hemostatics; D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa