HI: haplotype improver using paired-end short reads.
CONCLUSIONS
We present a program to improve haplotype reconstruction by incorporating information from paired-end reads, and demonstrate its utility on simulated data. We find that given a fixed coverage, longer reads (implying fewer of them) are preferable.


BACKGROUND
The executable and user manual can be freely downloaded from ftp://ftp.sanger.ac.uk/pub/zn1/HI.
Long
Quan
Q
The Wellcome Trust Sanger Institute, Hinxton, Cambs, UK. ql2@sanger.ac.uk
MacArthur
Daniel
D
Ning
Zemin
Z
Tyler-Smith
Chris
C
D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D006239:Haplotypes; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012984:Software