Antimicrobial activity of Hymenaea martiana towards dermatophytes and Cryptococcus neoformans.
The biological activity of crude extract and fractions of Hymenaea martiana was evaluated against a panel of human pathogenic fungi. The crude extracts and hydroalcoholic fractions (E) showed a high activity against Cryptococcus neoformans species complex isolates with MICs between 2 and 64 μg ml(-1). The methanolic (C) and butanolic (D) fractions were the most active against Trichopyton rubrum, Trichopyton mentagrophytes and Microsporum canis with MICs between 8 and 256 μg ml(-1). None of the extracts was active against the yeast Malassezia furfur, Malassezia obtusa and Malassezia sympodialis.
de Souza
Ana Cristina Machado
AC
Laboratorio de Micologia da Universidade Federal de Goiás, Goiás, Brasil.
Kato
Lucilia
L
da Silva
Cleuza Conceição
CC
Cidade
Amanda Feitosa
AF
de Oliveira
Cecilia Maria Alves
CM
Silva
Maria do Rosário Rodrigues
Mdo R
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D006801:Humans; D052597:Hymenaea / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*
D000935:Antifungal Agents; D010936:Plant Extracts