title: Possible role of TORCH agents in congenital malformations in Gorgan, northern Islamic Republic of Iran.
abstract: This descriptive, cross-sectional study was carried out to explore the frequency of contamination with TORCH agents in neonates with congenital malformations in a referral centre in Gorgan city, Islamic Republic of Iran. Blood samples were taken from 64 neonates and their mothers over a 20-month period in 2003-04. Serologic tests showed that 4/64 infants born with congenital malformations (6%) had positive 1 gM antibody titres for Texoplasma gondil (2 cases), rubella virus (1 case) and cytomegalovirus (1 case). 1 gM was positive in 9/63 mothers (14%), also for T. gondil (3 cases), rubella virus (3 cases) and cytomegalovirus (3 cases). No cases of herpes simplex virus type II or Treponema pallidum were found.
authors: Gorgan Congenital Malformations Research Centre, Gorgan University of Medical Sciences, Gorgan, Islamic Republic of Iran. mjgolalipour@yahoo.com
authors: M J
authors: MJ
authors: Golalipour
authors: B
authors: B
authors: Khodabakhshi
authors: E
authors: E
authors: Ghaemi
mesh_terms: D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D015984:Causality; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D007492:Iran / Q000453:epidemiology; D008297:Male; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D012409:Rubella / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D012412:Rubella virus / Q000276:immunology; D014122:Toxoplasma / Q000276:immunology; D014125:Toxoplasmosis, Congenital / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D000914:Antibodies, Viral; D007075:Immunoglobulin M