title: Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability.
abstract: The role of atherosclerotic calcification in plaque rupture remains controversial. In previous analyses using finite element model analysis, circumferential stress was reduced by the inclusion of a calcium deposit in a representative human anatomical configuration. However, a recent report, also using finite element analysis, suggests that microscopic calcium deposits increase plaque stress. We used mathematical models to predict the effects of rigid and liquid inclusions (modeling a calcium deposit and a lipid necrotic core, respectively) in a distensible material (artery wall) on mechanical failure under uniaxial and biaxial loading in a range of configurations. Without inclusions, stress levels were low and uniform. In the analytical model, peak stresses were elevated at the edges of a rigid inclusion. In the finite element model, peak stresses were elevated at the edges of both inclusions, with minimal sensitivity to the wall distensibility and the size and shape of the inclusion. Presence of both a rigid and a soft inclusion enlarged the region of increased wall stress compared with either alone. In some configurations, the rigid inclusion reduced peak stress at the edge of the soft inclusion but simultaneously increased peak stress at the edge of the rigid inclusion and increased the size of the region affected. These findings suggest that the presence of a calcium deposit creates local increases in failure stress, and, depending on relative position to any neighboring lipid pools, it may increase peak stress and the plaque area at risk of mechanical failure.
authors: Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California 90095-1679, USA.
authors: Tetsuya
authors: T
authors: Hoshino
authors: Lori A
authors: LA
authors: Chow
authors: Jeffrey J
authors: JJ
authors: Hsu
authors: Alice A
authors: AA
authors: Perlowski
authors: Moeen
authors: M
authors: Abedin
authors: Jonathan
authors: J
authors: Tobis
authors: Yin
authors: Y
authors: Tintut
authors: Ajit K
authors: AK
authors: Mal
authors: William S
authors: WS
authors: Klug
authors: Linda L
authors: LL
authors: Demer
mesh_terms: D001158:Arteries / Q000473:pathology / Q000503:physiopathology; D050197:Atherosclerosis / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology*; D002114:Calcinosis / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D020342:Finite Element Analysis; D006801:Humans; D050356:Lipid Metabolism; D008955:Models, Cardiovascular; D009336:Necrosis; D012307:Risk Factors; D012422:Rupture, Spontaneous; D013314:Stress, Mechanical
chemical_list: D002118:Calcium