Hypothermia and rhabdomyolysis following olanzapine injection in an adolescent with schizophreniform disorder.
Hypothermia and rhabdomyolysis are infrequent adverse effects of antipsychotic drugs. Here we report a case of an adolescent with schizophreniform disorder who developed both of them simultaneously after intramuscular injection of olanzapine. A 17-year-old male patient was hospitalized for treatment of psychotic symptoms, which persisted on risperidone 3 mg/day for 3 weeks. Then his antipsychotic drug was shifted to oral olanzapine 10 mg/day. The next day, he received intramuscular injection of olanzapine 5 mg and soon developed hypothermia, rhabdomyolysis, hypotension and bradycardia. These symptoms subsided gradually in the next 2 weeks after supportive treatment was given. Such adverse effects were not observed in the following 7 months. Possible pharmacological mechanisms were discussed. Physicians should be cautious about patients' clinical symptoms after giving olanzapine injection or rapid titration in dosage.
Hung
Chi-Fa
CF
Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Huang
Tsan-Yu
TY
Lin
Pao-Yen
PY
D000284:Administration, Oral; D000293:Adolescent; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D001919:Bradycardia / Q000139:chemically induced; D016903:Drug Monitoring; D004357:Drug Synergism; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007035:Hypothermia / Q000139:chemically induced*; D007273:Injections, Intramuscular; D008297:Male; D000077152:Olanzapine; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D018967:Risperidone / Q000008:administration & dosage; D012449:Safety; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D013624:Taiwan
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine; D018967:Risperidone; D017367:Selective Serotonin Reuptake Inhibitors