Epidermal growth factor receptor signaling in liver cell proliferation and apoptosis.
Recent evidence suggests that epidermal growth factor receptor (EGFR)-dependent signaling contributes to liver cell proliferation, as well as to apoptotic liver cell death, and represents an important regulator of hepatic regeneration. This article summarizes recent findings on the molecular mechanisms involved in EGFR-mediated cell proliferation and apoptosis. The emphasis is on the interplay between EGFR and CD95 (Fas, APO-1) death receptor-signaling, which is determined by the signaling context and liver cell type investigated.
Reinehr
Roland
R
Clinic for Gastroenterology, Hepatology and Infectiology, University Hospital Düsseldorf, Heinrich Heine University, D-40225 Düsseldorf, Germany.
Häussinger
Dieter
D
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D049109:Cell Proliferation; D004789:Enzyme Activation / Q000502:physiology; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D022781:Hepatocytes / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D019014:fas Receptor / Q000378:metabolism*
D019014:fas Receptor; D066246:ErbB Receptors