title: Vascular risk factors and their association to serum androgen levels in a population-based cohort of 75-year-old men over 5 years: results of the VITA study.
abstract: OBJECTIVE
  In contrast to the high prevalence of late onset hypogonadism, little is known regarding correlates for low androgen levels in aging men.
  
  
  METHODS
  We investigated participants of the Vienna Transdanube Aging study and assessed the relationship between vascular risk factors and hormonal status over 5 years.
  
  
  RESULTS
  A total of 247 men with a mean age of 75.8 years were analyzed. Despite a tendency for lower testosterone levels in men with vascular risk factors and vascular diseases, none of these associations reached statistical significance. Men with low DHEA-S levels had a lower risk of hypercholesterinemia (-55.2%; P = 0.01) yet an increased prevalence of diabetes (+95.7%; P = 0.02) and coronary heart disease (+47.6%; P = 0.05). Testosterone and DHEA-S remained stable over 5 years of follow-up.
  
  
  CONCLUSIONS
  While reduced levels of total testosterone did not show an association to vascular disease, low DHEA-S was linked to hypercholesterinemia, diabetes, and coronary heart disease.
authors: Department of Urology and Andrology, Danube Hospital, SMZ-Ost, Langobardenstrasse 122, 1220 Vienna, Austria. anton.ponholzer@wienkav.at
authors: Anton
authors: A
authors: Ponholzer
authors: Stephan
authors: S
authors: Madersbacher
authors: Michael
authors: M
authors: Rauchenwald
authors: Susanne
authors: S
authors: Jungwirth
authors: Peter
authors: P
authors: Fischer
authors: Karl-Heinz
authors: KH
authors: Tragl
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism*; D050197:Atherosclerosis / Q000097:blood* / Q000453:epidemiology*; D001317:Austria / Q000453:epidemiology; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000453:epidemiology; D008137:Longitudinal Studies; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D013739:Testosterone / Q000097:blood* / Q000172:deficiency
chemical_list: D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone