title: Magnetic resonance investigations in Brugada syndrome reveal unexpectedly high rate of structural abnormalities.
abstract: OBJECTIVE
  Recent data suggest that sub-clinical structural abnormalities may be part of the Brugada syndrome (BrS) phenotype, a disease traditionally thought to occur in the structurally normal heart. In this study, we carried out detailed assessment of cardiac morphology and function using cardiac magnetic resonance imaging (CMRI).
  
  
  RESULTS
  Thirty consecutive patients with BrS were compared with 30 sex- (26/4 male/female), body surface area- (+/-0.2 m(2)), and age-matched (+/-5 years) normal volunteers. CMRI exam included long- and short-axis ECG-gated breath-hold morphological T1-TSE sequences for fatty infiltration and cine-SSFP sequences for kinetic assessment. Fatty infiltration was not found in any subject. Patients with BrS compared with normal subjects showed higher incidence of mild right ventricle (RV) wall-motion abnormalities [15 (50%) vs. 5 (17%) subjects (P = 0.006) with reduced radial fractional shortening in more than two segments], reduction of outflow tract ejection fraction (49 +/- 11% vs. 55 +/- 10%; P = 0.032), enlargement of the inflow tract diameter (46 +/- 4 vs. 41 +/- 5 mm, P < 0.001 in short-axis; 46 +/- 4 vs. 42 +/- 5 mm, P = 0.001 in four-chamber long-axis view) and area (22 +/- 2 vs. 20 +/- 3 cm(2); P = 0.050), and of global RV end-systolic volume (34 +/- 10 vs. 30 +/- 6 mL/m(2); P = 0.031) but comparable outflow tract dimensions, global RV end-diastolic volume, left ventricle parameters, and atria areas.
  
  
  CONCLUSIONS
  CMRI detects a high prevalence of mild structural changes of the RV, and suggests further pathophysiological complexity in BrS. Prospective studies to assess the long-term evolution of such abnormalities are warranted.
authors: Division of Cardiology, IRCCS Fondazione Salvatore Maugeri, via Maugeri 8, 27100 Pavia, Italy. oronzo.catalano@fsm.it
authors: Oronzo
authors: O
authors: Catalano
authors: Serena
authors: S
authors: Antonaci
authors: Guido
authors: G
authors: Moro
authors: Maria
authors: M
authors: Mussida
authors: Mauro
authors: M
authors: Frascaroli
authors: Maurizia
authors: M
authors: Baldi
authors: Franco
authors: F
authors: Cobelli
authors: Paola
authors: P
authors: Baiardi
authors: Janni
authors: J
authors: Nastoli
authors: Raffaella
authors: R
authors: Bloise
authors: Nicola
authors: N
authors: Monteforte
authors: Carlo
authors: C
authors: Napolitano
authors: Silvia G
authors: SG
authors: Priori
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D053840:Brugada Syndrome / Q000473:pathology* / Q000503:physiopathology; D016022:Case-Control Studies; D016757:Death, Sudden, Cardiac / Q000473:pathology; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D055815:Young Adult