Risk of medically attended local reactions following diphtheria toxoid containing vaccines in adolescents and young adults: a Vaccine Safety Datalink study.
Three vaccines currently recommended for adolescents (Tdap, Td, and MCV4 meningococcal conjugate vaccine) contain diphtheria toxoid. While the safety of individual diphtheria toxoid containing vaccines has been evaluated, less is known regarding the safety of administration of two or more of these vaccines, either concomitantly or sequentially. This study evaluated the risk of medically attended local reactions in adolescents and young adults with varying patterns of receipt of diphtheria toxoid containing vaccines. In general the risk of medically attended local reactions was low and did not differ with concomitant or sequential administration of diphtheria toxoid containing vaccines.
Jackson
Lisa A
LA
Group Health Center for Health Studies, 1730 Minor Ave, Ste 1600, Seattle, WA 98101, United States. Jackson.L@ghc.org
Yu
Onchee
O
Nelson
Jennifer
J
Belongia
Edward A
EA
Hambidge
Simon J
SJ
Baxter
Roger
R
Naleway
Allison
A
Nordin
James
J
Baggs
James
J
Iskander
John
J
D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D004168:Diphtheria Toxoid / Q000009:adverse effects*; D022422:Diphtheria-Tetanus Vaccine / Q000009:adverse effects*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D022401:Meningococcal Vaccines / Q000009:adverse effects*; D018074:Vaccines, Conjugate / Q000009:adverse effects; D055815:Young Adult
D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D022401:Meningococcal Vaccines; D018074:Vaccines, Conjugate