Synthesis and stereochemical determination of the spirastrellolides.
This Highlight summarises synthetic efforts towards the marine sponge-derived antimitotic agent spirastrellolide A and its congeners, including the first total synthesis by Paterson and co-workers.
Paterson
Ian
I
University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK. ip100@cam.ac.uk
Dalby
Stephen M
SM
D000818:Animals; D050256:Antimitotic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013141:Spiro Compounds; D013237:Stereoisomerism
D050256:Antimitotic Agents; D018942:Macrolides; D013141:Spiro Compounds; C475125:spirastrellolide A