title: Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.
abstract: Neglected diseases represent a major health problem. It is estimated that one third of the world population is infected with tuberculosis (TB). Besides TB, Chagas disease, affects approximately 20 million people. Quinoxalines display great activities against TB and Chagas. Forty new quinoxaline 1,4-di-N-oxide derivatives have been prepared and tested against M. tuberculosis and T. cruzi. Carboxylic acid quinoxaline 1,4-di-N-oxides (CAQDOs) 5 and 17 showed MIC values on the same order as the reference antituberculosis drug, rifampicin. Meanwhile, CAQDOs 12 and 22 presented IC(50) values in the same order as the anti-chagasic drug, nifurtimox.
authors: Unidad en Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada, University of Navarra, C/Irunlarrea s/n, 31008 Pamplona, Spain.
authors: Saioa
authors: S
authors: Ancizu
authors: Elsa
authors: E
authors: Moreno
authors: Enrique
authors: E
authors: Torres
authors: Asunción
authors: A
authors: Burguete
authors: Silvia
authors: S
authors: Pérez-Silanes
authors: Diego
authors: D
authors: Benítez
authors: Raquel
authors: R
authors: Villar
authors: Beatriz
authors: B
authors: Solano
authors: Adoración
authors: A
authors: Marín
authors: Ignacio
authors: I
authors: Aldana
authors: Hugo
authors: H
authors: Cerecetto
authors: Mercedes
authors: M
authors: González
authors: Antonio
authors: A
authors: Monge
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011810:Quinoxalines / Q000737:chemistry* / Q000494:pharmacology*; D012293:Rifampin; D014345:Trypanosoma / Q000187:drug effects
chemical_list: D000995:Antitubercular Agents; D011810:Quinoxalines; D012293:Rifampin