[Postprandial changes of blood lipid after ordinary Chinese diet and the influencing factors thereof].
OBJECTIVE
To investigate the postprandial changes of blood lipid after ordinary Chinese diet and the influencing factors thereof.


METHODS
Peripheral venous blood samples were collected from 88 patients, 72 males and 16 females, aged (65 +/- 12), 53 with hypertension, 35 with coronary heart diseases, and 27 with diabetes, while fasting and 4 h after breakfast and lunch to measure the levels of lipoproteins, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (ApoA), ApoB, lipoprotein (Lp) (a), oxidized LDL (ox-LDL). Homeostasis model assessment insulin resistance index (HOMA-IR) was calculated. Weight, height, waist circumference, and hip circumference were examined, and body mass index (BMI) and waist/hip ratio (WHR) were calculated.


RESULTS
The TG level after breakfast was (2.79 +/- 0.19) mmol/L, significantly higher than the fasting level by 49.5% [(1.94 +/- 0.13) mmol/L, P < 0.05]. The TG level after lunch was (3.08 +/- 0.26) mmol/L, significantly higher than the fasting level by 58.8% [(1.94 +/- 0.13) mmol/L, P < 0.05]. The ox-LDL after breakfast was (430 +/- 21) microg/L, significantly higher than the fasting level by 32.6% [(324 +/- 14) microg/L, P < 0.05] and the ox-LDL level after lunch was (448 +/- 17) microg/L, significantly higher than the fasting level by 38.1% [(324 +/- 14) microg/L, P < 0.05]. The fasting insulin level was (62 +/- 4) pmol/L, and the HOMA-IR was (15.27 +/- 1.08). The fasting insulin level was positively correlated with the fasting and postprandial TG levels (all P < 0.01). The IR index was positively correlated with the fasting TG and TG after breakfast (both P < 0.05). Fasting insulin and HOMA-IR were negatively correlated with the fasting and postprandial HDL-C levels (all P < 0.05), and positively correlated with the fasting and postprandial TC/HDL-C levels (all P < 0.05). BMI and WHR were negatively correlated with the fasting and postprandial HDL-C (both P < 0.01). BMI was positively correlated with fasting and postprandial TG (both P < 0.05). The insulin level, HOMA-IR, and BMI were negatively correlated with LPL (r = -0.232 - 0.297, P < 0.05). LPL were positively correlated with fasting and postprandial HDL-C levels (r = 0.37, 0.31, 0.35, all P < 0.01).


CONCLUSIONS
The TG and ox-LDL levels significantly increased postprandially. The postprandial blood lipid levels are significantly correlated with the fasting blood lipids.
Fu
Zhi-fang
ZF
Department of Geriatrics, First Hospital of Peking University, Beijing 100034, China.
Liu
Mei-lin
ML
D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000503:physiopathology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007297:Inpatients; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides