Genomic characterization of the human mitochondrial tumor suppressor gene 1 (MTUS1): 5' cloning and preliminary analysis of the multiple gene promoters.
BACKGROUND
Mitochondrial tumor suppressor gene 1 (MTUS1) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several tumor types. It has been suggested that multiple gene promoters and alternative splicing lead to the expression of 5 known MTUS1 transcript variants.


RESULTS
Here, we characterized the 5' untranslated regions of the different transcript variants. We also cloned and functionally tested the alternatively utilized gene promoters that contribute to the production of different MTUS1 transcript variants.


CONCLUSIONS
Our results confirmed the early hypothesis that the transcript variants of MTUS1 gene are driven by multiple gene promoters.
Yu
Jinsheng
J
Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA. jinsheng@uic.edu
Liu
Xiqiang
X
Ye
Hui
H
Zhou
Xiaofeng
X