Two flavonoid dimers from Sarcandra hainanensis (PEI) SWAMY et BAILEY.
Two new flavonoid dimers (1, 2) consisting of flavan-chalcone together with three known compounds (3-5) were isolated from the ethanol extract of the whole plants of Sarcandra hainanensis. Their structures were determined by extensive spectroscopic analysis. Human immunodeficiency virus-1 integrase inhibition activities of compounds 1 and 2 were evaluated and they showed weak activities with IC(50) at 18.05 and 25.27 muM, respectively.
Cao
Cong-Mei
CM
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College.
Peng
Yong
Y
Xu
Li-Jia
LJ
Wang
Ya-Jun
YJ
Yang
Jun-Shan
JS
Xiao
Pei-Gen
PG
D004791:Enzyme Inhibitors; D047309:Flavones / Q000737:chemistry*; D019427:HIV Integrase; D019684:Magnoliopsida / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
D004791:Enzyme Inhibitors; D047309:Flavones; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1