Effect of salvia miltiorrhizae on pulmonary apoptosis of rats with severe acute pancreatitis or obstructive jaundice.
To investigate the effect of apoptosis about Salvia miltiorrhizae injection on the lungs of SAP and OJ rats. Total 288 rats were used for SAP-associated experiments and OJ-associated experiments, respectively. The rats were randomly divided into sham-operated, model control and treated group. According to the difference of time points after operation, the SAP rats in each group were subdivided into 3, 6 and 12 h groups while the OJ rats were divided into 7, 14, 21 and 28 days groups. The pathological changes, expression levels of Bax protein and apoptotic indexes in the lungs of SAP or OJ rats were observed, and the mortality rates of SAP or OJ rats were recorded, respectively. The numbers of dead SAP and OJ rats in treated groups declined. The pathological changes in the lungs of SAP or OJ rats in treated groups were relieved to varying degrees. There was no marked difference in pathological severity scores and the positive staining intensity of Bax protein between treated groups and model control groups (all P > 0.05). Salvia miltiorrhizae has some protective effect on the lungs of rats with SAP or OJ which may be related apoptosis although our results can not find significant difference between treated groups and model control groups.
Xiping
Zhang
Z
Department of General Surgery, Hangzhou First People's Hospital, Zhejiang Province, China.
Jun
Fu
F
Chengjun
Wu
W
Meili
Ma
M
Ping
Yan
Y
Jing
Ye
Y
Qijun
Yang
Y
Feibo
Zhu
Z
Rongcao
Ying
Y
D000208:Acute Disease; D000818:Animals; D017209:Apoptosis; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D041781:Jaundice, Obstructive / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D010195:Pancreatitis / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza; D012720:Severity of Illness Index; D015996:Survival Rate; D051028:bcl-2-Associated X Protein / Q000032:analysis
D010936:Plant Extracts; D051028:bcl-2-Associated X Protein