[A case of marked response to CPT-11+CDDP neoadjuvant chemotherapy for advanced gastric cancer with paraaortic lymph node metastasis enabling curative resection and over 10-year survival].
We report a case of advanced gastric carcinoma successfully treated with a combination of irinotecan and cisplatin as neoadjuvant chemotherapy. The patient, a 51-year-old woman, had a type 2 gastric carcinoma, which had metastasized to paraaortic lymph nodes. She was treated with irinotecan, 70 mg on day 1 and day 15, and cisplatin, 80 mg on day 1. The course was repeated every 4 weeks. Two courses of treatment resulted in a marked reduction of both the primary tumor and lymph nodes. Subsequently, the patient underwent curative surgery consisting of pancreatoduodenectomy and D3 lymph node dissection. No surgical complication was observed. On microscopic examination, only a few tumor cells were detected in the granulation tissues of the lymph nodes, but viable cancer cells still remained in the resected stomach. This patient has been free of disease for more than 10 years after operation. This case demonstrates the effectiveness and safety of irinotecan and cisplatin used in an neoadjuvant setting for treatment of advanced gastric carcinoma.
Suzuki
Yozo
Y
Dept. of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Japan.
Iwasaki
Yoshiaki
Y
Ohashi
Manabu
M
Nunobe
Souya
S
Iwanaga
Tomohiro
T
Takahashi
Keiichi
K
Yamaguchi
Tatsurou
T
Matsumoto
Hiroshi
H
Nakano
Daisuke
D
Hishima
Tsunekazu
T
D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001011:Aorta; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008207:Lymphatic Metastasis; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D013274:Stomach Neoplasms / Q000401:mortality / Q000601:surgery / Q000628:therapy*
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin