title: Synthesis, in vitro antitubercular activity and 3D-QSAR study of 1,4-dihydropyridines.
abstract: In continuation of our research program on new antitubercular agents, this article is a report of the synthesis of 97 various symmetrical, unsymmetrical, and N-substituted 1,4-dihydropyridines. The synthesized molecules were tested for their activity against M. tuberculosis H (37)Rv strain with rifampin as the standard drug. The percentage inhibition was found in the range 3-93%. In an effort to understand the relationship between structure and activity, 3D-QSAR studies were also carried out on a subset that is representative of the molecules synthesized. For the generation of the QSAR models, a training set of 35 diverse molecules representing the synthesized molecules was utilized. The molecules were aligned using the atom-fit technique. The CoMFA and CoMSIA models generated on the molecules aligned by the atom-fit method show a correlation coefficient (r (2)) of 0.98 and 0.95 with cross-validated r (2)(q (2)) of 0.56 and 0.62, respectively. The 3D-QSAR models were externally validated against a test set of 19 molecules (aligned previously with the training set) for which the predictive r(2)(r(r)(pred)) is recorded as 0.74 and 0.69 for the CoMFA and CoMSIA models, respectively. The models were checked for chance correlation through y-scrambling. The QSAR models revealed the importance of the conformational flexibility of the substituents in antitubercular activity.
authors: Department of Chemistry, Saurashtra University, Rajkot, 360 005, Gujarat, India.
authors: Atul T
authors: AT
authors: Manvar
authors: Raghuvir R S
authors: RR
authors: Pissurlenkar
authors: Vijay R
authors: VR
authors: Virsodia
authors: Kuldip D
authors: KD
authors: Upadhyay
authors: Dinesh R
authors: DR
authors: Manvar
authors: Arun K
authors: AK
authors: Mishra
authors: Hrishikesh D
authors: HD
authors: Acharya
authors: Alpesh R
authors: AR
authors: Parecha
authors: Chintan D
authors: CD
authors: Dholakia
authors: Anamik K
authors: AK
authors: Shah
authors: Evans C
authors: EC
authors: Coutinho
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003198:Computer Simulation; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D004095:Dihydropyridines