Physiological variables involved in heart valve substitute calcification.
Biochemical, histological and genetic studies using in vitro/in vivo models have demonstrated that pathological calcification of bioprosthetic heart valves (BHV) is regulated by various mechanisms associated with physiological variables. The major objective of this review is to characterize physiological variables involved in BHV calcification. This review examines our understanding of the systemic cellular behavior and physiological regulation processes behind BHV calcification and its clinical applications.
Lee
Chi H
CH
University of Missouri-Kansas City, School of Pharmacy, Department of Pharmaceutical Sciences, Kansas City, MO 64110, USA. Leech@umkc.edu
D000818:Animals; D001705:Bioprosthesis; D002114:Calcinosis / Q000473:pathology; D003198:Computer Simulation; D006349:Heart Valve Diseases / Q000628:therapy*; D006350:Heart Valve Prosthesis; D006351:Heart Valves / Q000378:metabolism / Q000473:pathology*; D006439:Hemodynamics; D006801:Humans; D023421:Models, Animal; D010477:Perfusion; D011475:Prosthesis Failure; D011817:Rabbits; D051381:Rats; D012756:Sheep