Tissue persistence of fumonisin B1 in ducks and after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds.
Toxicity and persistence of fumonisin B1 (FB1) in liver, kidney and muscle were investigated in ducks fed 5, 10 and 20mg FB1+FB2/kg feed during force-feeding. Mortality and signs of toxicity were only obtained with 20mg/kg, whereas an increased Sa/So ratio was observed from 5mg/kg on. Persistence of FB1 was only found in liver (16 and 20 microg FB1/kg liver in ducks fed 10 and 20 mg FB1+FB2/kg feed, respectively). Toxicokinetic studies were conducted by the intravenous route (IV, single dose: 10mg FB1/kg body weight) and the oral route (single dose: 100mg FB1/kg body weight), in growing ducks and in ducks during force-feeding. After IV administration, serum concentration-time curves were described by a two-compartment open model. Elimination half-life and mean residence time of FB1 were 26 and 24 min, respectively, clearance was 19.3 ml/min/kg. After oral administration, bioavailability, elimination half-life, mean residence time and clearance varied during force-feeding and growth from 2-2.3%, 71-80 min, 200-188 min, 16.7-17 ml/min/kg, respectively. Taken together these results demonstrate that the risk of persistence of FB1 in ducks after force-feeding is very low, Sa/So being a good biomarker which increases before signs of toxicity and risk of persistence of FB1 in tissue (limit of detection 13 microg/kg).
Tardieu
Didier
D
ENVT, Mycotoxicology Unit, 23 chemin des capelles, BP 87614, 31076 Toulouse Cedex 3, France.
Bailly
Jean-Denis
JD
Benlashehr
Imad
I
Auby
Alienor
A
Jouglar
Jean-Yves
JY
Guerre
Philippe
P
D000821:Animal Feed / Q000009:adverse effects*; D000818:Animals; D004372:Ducks / Q000378:metabolism*; D037341:Fumonisins / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D005670:Fusarium / Q000737:chemistry; D008297:Male
D037341:Fumonisins; C056933:fumonisin B1