[Influence of three point mutations in TNF-alpha promoter gene in clinical manifestations and complications of stomach and duodenal ulcer].
The purpose of our study was to investigate whether polymorphisms -238G/A, -308G/A, and -863C/A within the promoter of the TNF-alpha gene are associated with clinical features of gastric and duodenal ulcer disease in a Russian population. DNA samples of 381 unrelated patients with gastric and duodenal ulcer disease and 216 sex- and age-matched healthy controls were used to determine the TNF-alpha gene polymorphisms by PCR-RFLP assay. Logistic regression analysis has revealed significant associations of polymorphism -308G/A with size of ulcerous defect (p=0.03) and intestinal dyspepsia (p=0.05), polymorphism -238G/A with gastric dyspepsia (p=0.04) and reflux-esophagitis (p=0.05), polymorphism -863C/A with perforation of ulcer (p=0.04). The study results highlight impact of the TNF-alpha gene polymorphisms on various clinical features in patients with peptic ulcer disease.
Polonikov
A V
AV
Ivanov
V P
VP
Solodilova
M A
MA
Shveĭnov
A I
AI
Manuĭlova
O S
OS
Kozhukhov
M A
MA
Tutochkina
M P
MP
Stepchenko
A A
AA
Bulgakova
I V
IV
D016022:Case-Control Studies; D004381:Duodenal Ulcer / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D006801:Humans; D016015:Logistic Models; D015999:Multivariate Analysis; D017354:Point Mutation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha