title: Chronic Budd-Chiari syndrome as a rare complication of Crohn's disease: a case report.
abstract: The Budd-Chiari syndrome (BCS) is characterized by hepatic venous outflow obstruction involving the hepatic veins, inferior vena cava, or both. BCS has occasionally been reported in the literature as a very rare complication of ulcerative colitis. However, association of Crohn's disease (CD) and BCS is extremely rare with only a single case reported in the world literature to date. We report a case of a young woman with chronically active, therapy-resistant CD who developed massive ascites, elevation of liver enzymes, and coagulopathy in the course of her disease. She was subsequently diagnosed with BCS for which a successful liver transplantation was performed. Chronically active therapy resistant CD and methylenetetrahydrofolate reductase gene mutation have been identified as possible risk factors for development of BCS in this patient.
authors: Division of Gastroenterology, University Hospital Zagreb - Rebro, Kispaticeva 12, Zagreb 10000, Croatia. marko.brinar@zg.htnet.hr
authors: Marko
authors: M
authors: Brinar
authors: Irena
authors: I
authors: Hrstic
authors: Silvija
authors: S
authors: Cukovic-Cavka
authors: Ranka Stern
authors: RS
authors: Padovan
authors: Silva
authors: S
authors: Zupancic-Salek
authors: Boris
authors: B
authors: Vucelic
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001201:Ascites / Q000000981:diagnostic imaging / Q000473:pathology; D006502:Budd-Chiari Syndrome / Q000000981:diagnostic imaging* / Q000209:etiology / Q000601:surgery*; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006503:Hepatic Veins / Q000000981:diagnostic imaging; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D016031:Liver Transplantation; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D009154:Mutation; D010690:Phlebography; D012307:Risk Factors; D016559:Tacrolimus / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014682:Vena Cava, Inferior / Q000000981:diagnostic imaging; D014859:Warfarin / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D014859:Warfarin; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D016559:Tacrolimus