title: Malaria antigen-mediated enhancement of interleukin-21 responses of peripheral blood mononuclear cells in African adults.
abstract: We recently showed that IL-21 is associated with high level of anti-EBA-175 IgG1 and IgG3. Here we have investigated the ability of two malarial antigens, Glutamate-rich protein and merozoite surface protein 3 to induce IL-21 production from PBMCs from malaria-exposed and non-exposed donors. We found that malaria-exposed donors produced significantly more IL-21 compared to non-exposed donors. These data suggest that IL-21 could be involved in the acquisition of immunity to malaria.
authors: Medical Research Unit, Albert Schweitzer Hospital, P.O. Box 118, Lambaréné, Gabon. mewono2@yahoo.fr
authors: Ludovic
authors: L
authors: Mewono
authors: Selidji T
authors: ST
authors: Agnandji
authors: Davy W
authors: DW
authors: Matondo Maya
authors: Anne-Marie Nkoma
authors: AM
authors: Mouima
authors: Berthe A
authors: BA
authors: Iroungou
authors: Saadou
authors: S
authors: Issifou
authors: Peter G
authors: PG
authors: Kremsner
mesh_terms: D000293:Adolescent; D000328:Adult; D000953:Antigens, Protozoan / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D007378:Interleukins / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D017780:Malaria Vaccines / Q000276:immunology; D016778:Malaria, Falciparum / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*; D055815:Young Adult; D000098546:Interleukin-21
chemical_list: D000953:Antigens, Protozoan; D007378:Interleukins; D017780:Malaria Vaccines; D015800:Protozoan Proteins; C089133:merozoite surface protein 3, Plasmodium; D016753:Interleukin-10; C072492:glutamate-rich protein, Plasmodium; D007371:Interferon-gamma; D000098546:Interleukin-21