Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase.
The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.
Spyridonidou
Katerina
K
Department of Pharmacy, Laboratory of Medicinal Chemistry, School of Health Sciences, University of Patras, 26500 Patras, Greece.
Fousteris
Manolis
M
Antonia
Marazioti
M
Chatzianastasiou
Athanasia
A
Papapetropoulos
Andreas
A
Nikolaropoulos
Sotiris
S
D000818:Animals; D002478:Cells, Cultured; D006152:Cyclic GMP / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000071756:Soluble Guanylyl Cyclase
D004791:Enzyme Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D007211:Indoles; D018160:Receptors, Cytoplasmic and Nuclear; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase; D006152:Cyclic GMP