title: New treatment for invasive fungal sinusitis: three cases of chronic invasive fungal sinusitis treated with surgery and voriconazole.
abstract: Invasive fungal sinusitis is a relatively rare disease and can be divided into acute fulminant, chronic, and granulomatous invasive fungal sinusitis. The conventional treatment is radical surgery combined with systemic amphotericin B administration, but the poor prognosis and unestablished treatment options require a better therapeutic strategy. We report three cases of chronic invasive fungal sinusitis successfully treated with a combination of surgery and voriconazole, a new antifungal agent, with good responses in all patients. Voriconazole administration could form the basis for a new standard treatment for invasive fungal sinusitis.
authors: Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi, Japan. kazuhiroe@gmail.com
authors: Kazuhiro
authors: K
authors: Nakaya
authors: Takeshi
authors: T
authors: Oshima
authors: Takayuki
authors: T
authors: Kudo
authors: Iori
authors: I
authors: Aoyagi
authors: Yukio
authors: Y
authors: Katori
authors: Jun
authors: J
authors: Ota
authors: Hiroshi
authors: H
authors: Hidaka
authors: Kiyoshi
authors: K
authors: Oda
authors: Toshimitsu
authors: T
authors: Kobayashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015523:Maxillary Sinusitis / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*; D015524:Sphenoid Sinusitis / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000009:adverse effects / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole