The platelet proteome.
OBJECTIVE
The proteome is the pool of proteins expressed at a given time and circumstance. The word 'proteomics' summarizes several technologies for visualization, quantitation and identification of these proteins. Recent advances in these techniques are helping to elucidate platelet processes which are relevant to bleeding and clotting disorders, transfusion medicine and regulation of angiogenesis.


RESULTS
Over 1100 platelet proteins have been identified using proteomic techniques. Various subproteomes have been characterized, including platelet releasates (the 'secretome'), alpha and dense granules, membrane and cytoskeletal proteins, platelet-derived microparticles, and the platelet 'phosphoproteome'. Proteomic data about platelets have become increasingly available in integrated databases.


CONCLUSIONS
Proteomic experiments in resting and activated platelets have identified novel signaling pathways and secreted proteins which may represent therapeutic targets, as well as potential cancer biomarkers.
Senzel
Lisa
L
Department of Pathology, University Hospital, State University of New York, Stony Brook, NY 11794-7300, USA. lsenzel@notes.cc.sunysb.edu
Gnatenko
Dmitri V
DV
Bahou
Wadie F
WF
D001792:Blood Platelets / Q000737:chemistry*; D055252:Cell-Derived Microparticles; D006801:Humans; D015539:Platelet Activation; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods; D015398:Signal Transduction
D020543:Proteome