[Meta-analysis on the relationship between colorectal cancer and Helicobacter pylori infection].
OBJECTIVE
Analyzing all the related studies that have been published in the world to evaluate the relationship between colorectal cancer (including colorectal adenomas) and Helicobacter pylori infection by means of Meta-analysis.


METHODS
To analyze the 14 references consistent with inclusion criteria by reviewing manager 4.2, calculating the odds ratio and 95% confidence interval, then drawing funnel plot. Results The total sample size is 3165, cases and controls are 1330 and 1835, respectively. The pooled OR is 1.36, and 95% confidence interval 1.01, 1.82. The graphical funnel plot appearing asymmetrical, but analyzing by sensitivity analysis and fail-safe number calculation. The results are affected by publication bias.


CONCLUSIONS
The results of our Meta-analysis show that Helicobacter pylori infection is a possible risk of colorectal cancer.
Zhang
Yan
Y
School of Public Health, Jining Medical University, Jining 272013, China.
Gao
Chang
C
Zhai
Jing-Hua
JH
D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D012307:Risk Factors