[Major depression invites major concerns].
OBJECTIVE
To overview limitations to the concept and construct of major depression.


METHODS
The objectives in initially conceptualizing major depression are examined against its subsequent utility and relevance to clinicians and researchers.


RESULTS
It is argued that, as defined, major depression does not differentiate clinical depression well from expressions of non-clinical depression or sadness, that its criteria set do not generate reliable diagnoses, that a diagnosis of major depression means little in and of itself (as it effectively comprises multiple types of depression) and that it fails to inform us about cause, natural history or differential treatment response.


CONCLUSIONS
Limitations to the concept of major depression would benefit from wider appreciation to advance changes to the clinical diagnosis of depressive sub-types.
Parker
Gordon
G
Escola de Psiquiatria, University of New South Wales, and Black Dog Institute, Prince of Wales Hospital, New South Wales, Australia.
Brotchie
Heather
H
D003863:Depression / Q000145:classification / Q000175:diagnosis*; D003865:Major Depressive Disorder / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D019964:Mood Disorders / Q000175:diagnosis; D011613:Psychotherapy; D013577:Syndrome