title: Preparation of 2-quinolones by sequential Heck reduction-cyclization (HRC) reactions by using a multitask palladium catalyst.
abstract: One-pot sequential Heck reduction-cyclization (HRC) reactions leading to the synthesis of substituted 2-quinolones have been developed by using a heterogeneous or mixed homogeneous/heterogeneous multitask palladium catalyst with charcoal as a support. The whole sequence occurs under very mild conditions without the need for additives (ligand or base) by taking advantage of the high reactivity of aryldiazonium salts as "super electrophiles". Recycling experiments showed that the reused heterogeneous Pd(0)/C catalyst was not able to promote another HRC sequence but was, however, still highly active for hydrogenation, hydrodehalogenation, as well as hydrogenolysis reactions.
authors: Université de Bordeaux, CNRS, Institut des Sciences Moléculaires, 351 Cours de la Libération, 33405 Talence, France. fx.felpin@ism.u-bordeaux1.fr
authors: François-Xavier
authors: FX
authors: Felpin
authors: Jérôme
authors: J
authors: Coste
authors: Cécile
authors: C
authors: Zakri
authors: Eric
authors: E
authors: Fouquet