[Hormones and osteoporosis update. Insulin/IGF-I and bone].
Insulin and insulin-like growth factor-I (IGF-I) are potent bone anabolic factors through the balance of distinct signals of the two adaptor molecules, insulin receptor substrate (IRS) -1 and IRS-2 : IRS-1 for maintenance of bone turnover by up-regulating anabolic and catabolic functions of osteoblasts, while IRS-2 for retaining the predominance of the anabolic function over the catabolic function.
Kawaguchi
Hiroshi
H
Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Japan.
D000818:Animals; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D055504:Insulin Receptor Substrate Proteins / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D017887:Ossification of Posterior Longitudinal Ligament / Q000209:etiology; D010006:Osteoblasts / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D015854:Up-Regulation
C526292:IRS1 protein, human; C526297:IRS2 protein, human; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; D007334:Insulin-Like Growth Factor I