Pharmacotherapy of sarcoma.
BACKGROUND
Comprising < 1% of adult malignancies and approximately 12% of pediatric malignancies, sarcomas are derived from a variety of connective tissues and exhibit highly variable responsiveness to therapy. The clinical and biologic heterogeneity of the > 50 histologic subtypes of sarcomas often require different therapeutic approaches.


OBJECTIVE
This review describes the use of therapeutic agents in the management of bone and soft-tissue sarcomas.


METHODS
Relevant literature is identified and presented from major conference proceedings, as well as using the PubMed search engine.


CONCLUSIONS
Chemotherapy has improved outcomes over the past few decade, particularly in patients with certain bone sarcomas and gastrointestinal stromal tumors; while in the majority of patients, additional strategies are necessary.
Chugh
Rashmi
R
University of Michigan, C407 Med Inn Building, 1500 E. Medical Center Dr, SPC 5848, Ann Arbor, MI 48109-5848, USA. rashmim@umich.edu
Baker
Laurence H
LH
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy*; D006801:Humans; D012509:Sarcoma / Q000188:drug therapy*