Clinicopathologic features of breast disease in Jamaica: findings of the Jamaican Breast Disease Study, 2000-2002.
OBJECTIVE
To describe the clinicopathologic profile of breast disease in Jamaica.


METHODS
The Jamaican Breast Disease Study is an ongoing prospective, multidisciplinary investigation of breast disease at the University Hospital of the West Indies (UHWI). The initial phase was a prevalence survey comprising all consenting patients referred to the Surgical Outpatient Department (SOPD) UHWI, for breast disease. Demographic, clinical, radiologic and pathologic information were recorded for each patient and the data for the first three years (2000-2002) were analyzed.


RESULTS
A total of 1189 patients was enrolled for the study period (28.8% of all new SOPD patients). The age range was 10 to 93 years (mean/SD = 36.5 +/- 16.4 years) with a female : male ratio of 14:1. Most patients (67.8%) presented with a palpable lump and the clinical diagnosis was benign in the majority (70.4%) of patients. Fibroadenoma was the most common benign histologic result (39.4% of all biopsies) followed by non-proliferative (fibrocystic) disease (19.3% of all biopsies). Proliferative disease without atypia, complex fibroadenoma and atypical ductal hyperplasia accounted for 6.9%, 2.6% and 0.4% of biopsies respectively. Overall, 23.4% of biopsies showed malignant histology (10.8% patients); invasive ductal carcinoma accounted for the majority of these cases (69.5%).


CONCLUSIONS
The majority of patients with breast disease in Jamaica are young women with clinically benign disease. There was a low prevalence of clinically significant premalignant disease. This is the first study to prospectively describe the clinicopathologic features of breast disease in Jamaica and supports the need for advocating breast cancer screening to facilitate detection of significant premalignant disease and early stages of breast cancer.
Shirley
S E
SE
Department of Pathology, Tropical Medicine Research Institute, The University of the West Indies, Kingston 7, Jamaica, West Indies. seshirley@cwjamaica.com
Mitchell
D I G
DI
Soares
D P
DP
James
M
M
Escoffery
C T
CT
Rhoden
A M
AM
Wolff
C
C
Choy
L
L
Wilks
R J
RJ
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D002648:Child; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D005348:Fibrocystic Breast Disease / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D007563:Jamaica / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D017678:Sex Distribution; D055815:Young Adult