[Retrospective analysis of maternal and infant birth features of hepatoblastoma patients].
OBJECTIVE
To explore the risk factors for hepatoblastoma.


METHODS
A case-cohort study using Logistic regression multiple variables analysis of medical record data sets was conducted to examine infant and perinatal risk factors for hepatoblastoma.


RESULTS
Birth weight less than 1,000 g was associated with a strongly increased risk of hepatoblastoma (odds risk, OR = 26.0, 95% confidence interval, CI: 14.0 to 65.7). After adjustment of birth weight, a moderately increased risk of hepatoblastoma was found for older maternal age ( > 35 years vs. 20 to 34 years: OR = 2.6, 95% CI: 0.9 to 5.9), maternal smoking (OR = 2.9, 95% CI: 1.1 to 4.2) and higher maternal pregnancy body mass index (OR = 3.2, 95% CI: 1.0 to 6.7).


CONCLUSIONS
Very low birth weight and maternal characteristics including overweight, smoking are associated with hepatoblastoma risk.
Pu
Cong-lun
CL
Department of Hepatobiliary Surgery, Children's Hospital, Chongqing Medical University, Chongqing, China.
Guo
Chun-bao
CB
Jin
Xian-qing
XQ
Deng
Chun
C
Zhang
Ming-man
MM
Li
Ying-cun
YC
Kang
Quan
Q
D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D018197:Hepatoblastoma / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D050177:Overweight; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects