title: Use of hydroxyapatite ceramics for treatment of nonunited osseous defect after open fracture of lower limbs.
abstract: BACKGROUND
  Osseous defects in nonunited open fracture of the lower limbs are difficult to treat. Autogenous bone grafting is a promising treatment options, but a finite amount of autogenous bone graft is available from each individual and donor site morbidity remains a problem. These limitations have prompted the development and use of synthetic biomaterials such as hydroxyapatite (HA) ceramics. However, little information is available regarding the challenging cases such as nonunited open fractures The purpose of the present study is to evaluate the outcomes associated with the treatment of osseous defects in nonunited open fracture using novel HA ceramics.
  
  
  METHODS
  Twelve bones (4 femora and 8 tibias) in 11 patients (10 men and 1 woman), with an average age of 49.1 (range 19-71) years, with nonunited osseous defects after open fracture were treated by the grafting of HA ceramics alone or with autogenous iliac bone followed by internal or external fixation.
  
  
  RESULTS
  The patients were followed for an average of 25.2 months in average (range 10.3 -58.1 months). Finally, 11 of 12 fractures united clinically and radiographically, while one fracture required a second procedure for additional autogenous iliac bone grafting. The average time to union from the index surgery was 5.6 months (median 5.3 months, range 2.3-11 months.). Radiographs showed good incorporation of grafted HA into the host bone in most of the united cases. As a complication, transient wound drainage was found in two cases.
  
  
  CONCLUSIONS
  The current protocol using the HA ceramics appears to be safe and efficacious for the treatment of osseous defects after the open fractures.
authors: Department of Orthopaedic Surgery, Hoshigaokakouseinenkin Hospital, Hirakata-City, Osaka, Japan. tnakase@ff.iij4u.or.jp
authors: Takanobu
authors: T
authors: Nakase
authors: Masakazu
authors: M
authors: Fujii
authors: Akira
authors: A
authors: Myoui
authors: Noriyuki
authors: N
authors: Tamai
authors: Yasuhisa
authors: Y
authors: Hayaishi
authors: Takafumi
authors: T
authors: Ueda
authors: Masayuki
authors: M
authors: Hamada
authors: Hideo
authors: H
authors: Kawai
authors: Hideki
authors: H
authors: Yoshikawa
mesh_terms: D000328:Adult; D000368:Aged; D016025:Bone Transplantation / Q000379:methods*; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000601:surgery*; D005500:Follow-Up Studies; D005593:Fracture Fixation, Internal / Q000379:methods*; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D017886:Durapatite