Spatio-temporal control of cell coculture interactions on surfaces.
Coculture control: We report a combined photochemical and electroactive self-assembled monolayer (SAM)-based substrate strategy to generate a coculture platform with spatial and temporal control of cell-cell interactions. These dynamic substrates can present a variety of ligands on the surface for biospecific interactions between the ligands and cell surface receptors. Photopatterning enables the ligands to be immobilized in patterns and even gradients.
Lee
Eun-Ju
EJ
Department of Chemistry and the Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA.
Chan
Eugene W L
EW
Yousaf
Muhammad N
MN
D000199:Actins / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001547:Benzaldehydes / Q000737:chemistry; D002448:Cell Adhesion; D018920:Coculture Techniques / Q000295:instrumentation* / Q000379:methods; D004563:Electrochemistry; D049452:Green Fluorescent Proteins / Q000737:chemistry / Q000378:metabolism; D006873:Hydroquinones / Q000737:chemistry; D008024:Ligands; D051379:Mice; D013499:Surface Properties; D041701:Swiss 3T3 Cells; D014162:Transfection; D014466:Ultraviolet Rays
D000199:Actins; D001547:Benzaldehydes; D006873:Hydroquinones; D008024:Ligands; C402308:NVOC-chloride; D049452:Green Fluorescent Proteins; C031927:hydroquinone