title: Ultrasound characteristics of breast fibroadenomas are related to clinical and histological parameters.
abstract: OBJECTIVE
  We hypothesized that ultrasound characteristics of breast fibroadenomas (FA) vary in relation to the clinical and histological parameters: patient age, tumor size and histological classification.
  
  
  METHODS
  Eleven ultrasound characteristics frequently observed in breast tumors were defined before the onset of our study. These characteristics, as well as a semi-quantitative score for vascularization on color-coded Doppler ultrasound, were analyzed in a retrospective study. Histology revealed adult type differentiation in all FA. They were divided into florid, regressive and mixed subtypes. The examiner was blinded for the histological classification during image analysis.
  
  
  RESULTS
  Histological type: florid FA: more frequent in younger women (age group < 30 years; p < 0.001), and bigger than regressive FA (larger than 16 mm: p = 0.007). Statistically significant differences between florid and regressive FA regarding the ultrasound features: enhanced posterior ultrasound transmission (p < 0.001), homogenous echo pattern (p = 0.003) and lobulated margin contour (p = 0.042). Tumor size: patients with larger tumors (> 16 mm) were younger (mean age 35 vs. 43 years, p < 0.001). More often in bigger FA: enhanced dorsal ultrasound transmission (p < 0.001), hyperechoic spots (p < 0.001), strong vascularization (p < 0.001), inhomogeneous echo pattern (p = 0.001), horizontal axis (p = 0.009), lobulated margin contour (p = 0.009), lateral shadowing (p = 0.047). Age: more often in older patients (age group > 30 years): dorsal ultrasound shadowing (p = 0.008), irregular margin contour (p = 0.038), homogenous echo pattern (p = 0.047).
  
  
  CONCLUSIONS
  Histological type, tumor size and patient age significantly influence ultrasound characteristics of breast FA. This might be helpful to consider when breast lesions are classified and decisions for biopsies are made.
authors: Obstetrics & Gynecology, University Hospital Freiburg, Freiburg. martha.foeldi@uniklinikfreiburg.de
authors: M
authors: M
authors: Földi
authors: M
authors: M
authors: Klar
authors: M
authors: M
authors: Orlowska-Volk
authors: A
authors: A
authors: Hanjalic-Beck
authors: B
authors: B
authors: Osterloh
authors: E
authors: E
authors: Stickeler
authors: D
authors: D
authors: Watermann
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D018226:Fibroadenoma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging / Q000473:pathology; D012680:Sensitivity and Specificity; D047368:Tumor Burden; D018615:Ultrasonography, Doppler, Color; D016217:Ultrasonography, Mammary; D055815:Young Adult