title: Characterization of ethylcellulose: starch-based film coatings for colon targeting.
abstract: BACKGROUND
  The site-specific delivery of drugs to the colon can be highly advantageous for various applications, including the local treatment of inflammatory bowel diseases. The aim of this study was to provide efficient tools that can be used to easily adjust the key properties of novel polymeric film coatings allowing for colon targeting.
  
  
  METHODS
  Free films based on blends of ethylcellulose and different types of starch derivatives (partially being pregelatinized, acetylated, and/or hydroxypropylated) were prepared and characterized.
  
  
  RESULTS
  The key properties of the polymeric systems can effectively be adjusted by varying the polymer blend ratio and type of starch derivative. This includes the water uptake and dry mass loss kinetics as well as the mechanical properties of the films before and upon exposure to aqueous media simulating the contents of the upper GIT.
  
  
  CONCLUSIONS
  Broad ranges of film coating properties can easily be provided, being adapted to the needs of the respective drug treatment.
authors: College of Pharmacy, University of Lille, Lille, France.
authors: Youness
authors: Y
authors: Karrout
authors: Christel
authors: C
authors: Neut
authors: Daniel
authors: D
authors: Wils
authors: Florence
authors: F
authors: Siepmann
authors: Laetitia
authors: L
authors: Deremaux
authors: Pierre
authors: P
authors: Desreumaux
authors: Juergen
authors: J
authors: Siepmann
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003106:Colon / Q000378:metabolism; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D013213:Starch / Q000737:chemistry*; D014867:Water / Q000378:metabolism
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D014867:Water; C013517:ethyl cellulose; D002482:Cellulose; D013213:Starch