title: Scales as outcome measures for Alzheimer's disease.
abstract: The assessment of patient outcomes in clinical trials of new therapeutics for Alzheimer's disease (AD) continues to evolve. In addition to assessing drugs for symptomatic relief, an increasing number of trials are focusing on potential disease-modifying agents. Moreover, participants with AD are being studied earlier in their course of disease. As a result, the limitations of current outcome measures have become more apparent, as has the need for better instruments. In recognition of the need to review and possibly revise current assessment measures, the Alzheimer's Association, in cooperation with industry leaders and academic investigators, convened a Research Roundtable meeting devoted to scales as outcome measures for AD clinical trials. The meeting included a discussion of methodological issues in the use of scales in AD clinical trials, including cross-cultural issues. Specific topics related to the use of cognitive, functional, global, and neuropsychiatric scales were also presented. Speakers also addressed academic and industry initiatives for pooling data from untreated and placebo-treated patients in clinical trials. A number of regulatory topics were also discussed with agency representatives. Panel discussions highlighted areas of controversy, in an effort to gain consensus on various topics.
authors: Wyeth Research, Collegeville, PA, USA.
authors: Ronald
authors: R
authors: Black
authors: Barry
authors: B
authors: Greenberg
authors: J Michael
authors: JM
authors: Ryan
authors: Holly
authors: H
authors: Posner
authors: Jeffrey
authors: J
authors: Seeburger
authors: Joan
authors: J
authors: Amatniek
authors: Malca
authors: M
authors: Resnick
authors: Richard
authors: R
authors: Mohs
authors: David S
authors: DS
authors: Miller
authors: Daniel
authors: D
authors: Saumier
authors: Maria C
authors: MC
authors: Carrillo
authors: Yaakov
authors: Y
authors: Stern
mesh_terms: D000046:Academic Medical Centers / Q000592:standards; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D002986:Clinical Trials as Topic / Q000379:methods / Q000592:standards*; D004185:Disability Evaluation; D004345:Drug Industry / Q000592:standards; D006801:Humans; D015201:Meta-Analysis as Topic; D009483:Neuropsychological Tests / Q000592:standards*; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000592:standards*; D012720:Severity of Illness Index