title: Increased HIF-1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides.
abstract: BACKGROUND
  Expression of hypoxia inducible factor 1 (HIF-1) alpha can be linked to inflammation through reciprocal interactions with several cytokines. This finding is in accordance with the previously noted HIF-1 alpha overexpression in psoriatic lesional keratinocytes.
  
  
  METHODS
  In this study we have employed a carefully selected panel of antibodies and quantitative morphometric analysis to compare HIF-1 alpha immunoreactivity in psoriatic biopsy samples vs. that in samples obtained from psoriasiform dermatitides.
  
  
  RESULTS
  We found statistically significant HIF-1 alpha overexpression in psoriasis. Furthermore, we observed a previously unreported preferential localization of immunoreactive keratinocytes in the immediate vicinity of inflamed and elongated papillae. This pattern of immunoreactivity may partially account for the observed increase of HIF-1 alpha immunostaining in psoriasis.
  
  
  CONCLUSIONS
  Overall, our findings imply that possible novel therapeutic intervention(s) on the HIF-1 alpha pathway may offer another approach in controlling the inflammatory activity of psoriatic lesions.
authors: Department of Pathology, Medical School, University of Thessaly, Larissa, Greece.
authors: Maria
authors: M
authors: Ioannou
authors: Fani
authors: F
authors: Sourli
authors: Ilias
authors: I
authors: Mylonis
authors: Sotirios
authors: S
authors: Barbanis
authors: Rodula
authors: R
authors: Papamichali
authors: Evangelos
authors: E
authors: Kouvaras
authors: Efterpi
authors: E
authors: Zafiriou
authors: Paraskevi
authors: P
authors: Siomou
authors: Eleni
authors: E
authors: Klimi
authors: George
authors: G
authors: Simos
authors: Aggeliki-Victoria
authors: AV
authors: Roussaki-Schulze
authors: George
authors: G
authors: Koukoulis
mesh_terms: D003872:Dermatitis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis*; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D011565:Psoriasis / Q000378:metabolism* / Q000473:pathology
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit