title: High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503.
abstract: The acetylcholinesterase (AChE) inhibitor donepezil is also a sigma1 receptor agonist. We examined whether donepezil binds to sigma1 receptors in the living human brain after a single oral administration. Dynamic positron emission tomography (PET) data acquisition using the selective sigma1 receptor ligand [11C]SA4503 was performed to evaluate quantitatively the binding of [11C]SA4503 to sigma1 receptors in eight healthy male volunteers. Each subject had a PET scan before and after receiving a single dose of donepezil (5 or 10 mg). The binding potential of [11C]SA4503 was calculated. Doses of 5 mg and 10 mg donepezil bound to sigma1 receptors in the human brain with occupancies of approximately 60% and approximately 75%, respectively, in a dose-dependent manner. This study demonstrated that donepezil binds to sigma1 receptors in the living human brain at therapeutic doses. Therefore, sigma1 receptors may be implicated in the pharmacological mechanism of donepezil in the human brain.
authors: Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.
authors: Masatomo
authors: M
authors: Ishikawa
authors: Muneyuki
authors: M
authors: Sakata
authors: Kenji
authors: K
authors: Ishii
authors: Yuichi
authors: Y
authors: Kimura
authors: Keiichi
authors: K
authors: Oda
authors: Jun
authors: J
authors: Toyohara
authors: Jin
authors: J
authors: Wu
authors: Kiichi
authors: K
authors: Ishiwata
authors: Masaomi
authors: M
authors: Iyo
authors: Kenji
authors: K
authors: Hashimoto
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects*; D001931:Brain Mapping; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D000077265:Donepezil; D006801:Humans; D007189:Indans / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology*; D049268:Positron-Emission Tomography / Q000379:methods; D011869:Radioligand Assay; D017480:Receptors, sigma / Q000819:agonists / Q000378:metabolism*; D055815:Young Adult
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D010879:Piperazines; D010880:Piperidines; D017480:Receptors, sigma; D000077265:Donepezil; C101789:SA 4503