title: Comparison of lung scintigraphy with multi-slice spiral computed tomography in the diagnosis of pulmonary embolism.
abstract: OBJECTIVE
  To compare the diagnostic efficacy of lung perfusion scans combined with ventilation (V/Q) scans and/or chest radiography (CR) with contrast-enhanced multislice spiral CT pulmonary angiography (CTPA) in diagnosing pulmonary embolism (PE).
  
  
  METHODS
  Eighty-two consecutive patients with suspected PE underwent CTPA, lung perfusion scan, and CR. Of them, 28 patients underwent V/Q scans. The final diagnosis was made using a composite reference test.
  
  
  RESULTS
  The overall sensitivity and specificity were 89.2% and 92.1% for V/Q scan or perfusion scan combined with CR, and 97.3% and 97.4% for CTPA. For the 28 patients with V/Q scan, the sensitivity and specificity were 91.7% and 92.9% for V/Q scan, and 91.7% and 100.0% for CTPA. The segmental agreement rate between perfusion scan and CTPA was 69.5% (kappa = 0.30, P < 0.05). The perfusion scan revealed significantly more subsegmental abnormalities than CTPA (59 vs. 10, chi2 test, P < 0.05).
  
  
  CONCLUSIONS
  V/Q scan, perfusion scan combined with CR and CTPA all show high efficacy in diagnosing PE. V/Q scan or perfusion scan combined with CR is as accurate as CTPA.
authors: Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors: Feng
authors: F
authors: Wang
authors: Wei
authors: W
authors: Fang
authors: Bin
authors: B
authors: Lv
authors: Jin-Guo
authors: JG
authors: Lu
authors: Chang-Ming
authors: CM
authors: Xiong
authors: Xin-Hai
authors: XH
authors: Ni
authors: Zuo-Xiang
authors: ZX
authors: He
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013667:Technetium; D036542:Tomography, Spiral Computed; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium