title: Acute lymphoblastic leukemia (ALL) with t(8;14)(q11.2;q32) in an elderly patient.
abstract: Acute lymphoblastic leukemia (ALL) with chromosome aberration t(8;14)(q11.2;q32) mostly affects patients younger than 20 years old. One third of patients with this translocation have been reported to have Down syndrome. This translocation has been reported rarely in patients over the age of 50. Here we report a 71-year-old male ALL patient who carried t(8;14)(q11.2;q32). Fluorescence in situ hybridization (FISH) analysis revealed the involvement of CCAAT enhancer-binding protein delta (CEBPD) gene on chromosome 8, and IgH gene on chromosome 14. This case provides a new aspect for considering this clinical entity.
authors: Yasutaka
authors: Y
authors: Kubo
authors: Naoki
authors: N
authors: Kakazu
authors: Taizo
authors: T
authors: Tasaka
authors: Daigo
authors: D
authors: Oka
authors: Tadashi
authors: T
authors: Hirose
authors: Yoshiko
authors: Y
authors: Matsuhashi
authors: Hideho
authors: H
authors: Wada
authors: Kaoru
authors: K
authors: Tohyama
authors: Takashi
authors: T
authors: Sugihara
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D051743:CCAAT-Enhancer-Binding Protein-delta / Q000235:genetics; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D017809:Fatal Outcome; D050438:Genes, Immunoglobulin Heavy Chain; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C497252:CEBPD protein, human; D051743:CCAAT-Enhancer-Binding Protein-delta