[Effect of Ning Wei Kang Recipe extract on gastrointestinal motor function].
OBJECTIVE
To study the effect of Ning Wei Kang Recipe extract on gastrointestinal motor function.


METHODS
The effects of Ning Wei Kang Recipe extract on gastrointestinal motor function were studied in mice, rabbits, and isolated mesenterial intestines of guinea pig according to its effect on acetylcholine or barium chloride-induced contraction.


RESULTS
Ning Wei Kang Recipe extract could significantly decrease the propellent movement of medicine charcoal in the mesenterial intestine of mice (P < 0.01), inhibit the range and speed of mesenterial intestine of rabbits (P < 0.05, or P < 0.01), relax the contration of isolated mesenterial intestines of guinea pig induced by BaCl2 (P < 0.05). But it could not decrease the contration of isolated mesenterial intestines of guinea pig induced by acetylcholine (P< 0.05).


CONCLUSIONS
Ning Wei Kang Recipe extract can significantly inhibit the gastrointestinal motor function. It may be related to blocking positive ion-Ba2+ into gastrointestinal smooth muscle cell.
Huang
Yong-Mei
YM
Department of Pharmacy, Baiyun Hospital, Guangzhou 510500, China.
Deng
Jing-Zan
JZ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D017609:Barium Compounds; D002712:Chlorides; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects*; D006168:Guinea Pigs; D007077:Ileal Diseases / Q000139:chemically induced / Q000473:pathology*; D007422:Intestines / Q000187:drug effects; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D011897:Random Allocation; D013035:Spasm / Q000139:chemically induced / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D017609:Barium Compounds; D002712:Chlorides; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C024986:barium chloride