title: Examining the effects of two factors on working memory maintenance of bound information in schizophrenia.
abstract: Integrating information in space and time is a central feature of episodic memory. Although disturbance of the binding processes in episodic memory is well established in patients with schizophrenia, data on working memory (WM) remain discrepant. In a change detection procedure, two target displays of pairs of letters located in cells of grid were successively presented. Participants attempted to detect changes in binding information (i.e., recombination of studied features) or feature information (i.e., a novel letter and/or a novel spatial location). Recombinations consisted of features belonging to the same display (intradisplay) or different displays (interdisplays). Results showed that patients demonstrated overall lower performance, with no specific deficit for recognizing bound information or feature information. In addition, patients did not demonstrate deficits for interdisplay recombinations or intradisplay recombinations. Patients' ability to remember temporal occurrence of stimuli was not affected. Together, these results suggest that in patients with schizophrenia, binding processes in WM are not specifically disturbed.
authors: INSERM U.666, Physiopathologie clinique et expérimentale de la schizophrénie, Département de Psychiatrie, Hôpital Civil, Strasbourg Cedex, France. david.luck@mail.mcgill.ca
authors: David
authors: D
authors: Luck
authors: Lisa
authors: L
authors: Buchy
authors: Martin
authors: M
authors: Lepage
authors: Jean-Marie
authors: JM
authors: Danion
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008606:Mental Processes / Q000502:physiology*; D009483:Neuropsychological Tests; D011930:Reaction Time; D021641:Recognition, Psychology / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013028:Space Perception / Q000502:physiology