Unit-cell determination from randomly oriented electron-diffraction patterns.
Unit-cell determination is the first step towards the structure solution of an unknown crystal form. Standard procedures for unit-cell determination cannot cope with data collections that consist of single diffraction patterns of multiple crystals, each with an unknown orientation. However, for beam-sensitive nanocrystals these are often the only data that can be obtained. An algorithm for unit-cell determination that uses randomly oriented electron-diffraction patterns with unknown angular relationships is presented here. The algorithm determined the unit cells of mineral, pharmaceutical and protein nanocrystals in orthorhombic high- and low-symmetry space groups, allowing (well oriented) patterns to be indexed.
Jiang
Linhua
L
Department of Biophysical Structural Chemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands. l.jiang@chem.leidenuniv.nl
Georgieva
Dilyana
D
Zandbergen
Henny W
HW
Abrahams
Jan Pieter
JP
D000465:Algorithms; D000818:Animals; D002645:Chickens; D003460:Crystallization; D004583:Electrons; D008247:Lysosomes / Q000737:chemistry; D010400:Penicillin G / Q000737:chemistry; D014961:X-Ray Diffraction / Q000379:methods*
D010400:Penicillin G