title: Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study.
abstract: Musculoskeletal diseases, especially osteoarthritis (OA) and osteoporosis (OP), impair activities of daily life (ADL) and quality of life (QOL) in the elderly. Although preventive strategies for these diseases are urgently required in an aging society, epidemiological data on these diseases are scant. To clarify the prevalence of knee osteoarthritis (KOA), lumbar spondylosis (LS), and osteoporosis (OP) in Japan, and estimate the number of people with these diseases, we started a large-scale population-based cohort study entitled research on osteoarthritis/osteoporosis against disability (ROAD) in 2005. This study involved the collection of clinical information from three cohorts composed of participants located in urban, mountainous, and coastal areas. KOA and LS were radiographically defined as a grade of > or =2 by the Kellgren-Lawrence scale; OP was defined by the criteria of the Japanese Society for Bone and Mineral Research. The 3,040 participants in total were divided into six groups based on their age: < or =39, 40-49, 50-59, 60-69, 70-79, and > or =80 years. The prevalence of KOA in the age groups < or =39, 40-49, 50-59, 60-69, 70-79, and > or =80 years 0, 9.1, 24.3, 35.2, 48.2, and 51.6%, respectively, in men, and the prevalence in women of the same age groups was 3.2, 11.4, 30.3, 57.1, 71.9, and 80.7%, respectively. With respect to the age groups, the prevalence of LS was 14.3, 45.5, 72.9, 74.6, 85.3, and 90.1% in men, and 9.7, 28.6, 41.7, 55.4, 75.1, and 78.2% in women, respectively. Data of the prevalence of OP at the lumbar spine and femoral neck were also obtained. The estimated number of patients with KOA, LS, and L2-L4 and femoral neck OP in Japan was approximately 25, 38, 6.4, and 11 million, respectively. In summary, we estimated the prevalence of OA and OP, and the number of people affected with these diseases in Japan. The ROAD study will elucidate epidemiological evidence concerning determinants of bone and joint disease.
authors: Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. yoshimuran-ort@h.u-tokyo.ac.jp
authors: Noriko
authors: N
authors: Yoshimura
authors: Shigeyuki
authors: S
authors: Muraki
authors: Hiroyuki
authors: H
authors: Oka
authors: Akihiko
authors: A
authors: Mabuchi
authors: Yoshio
authors: Y
authors: En-Yo
authors: Munehito
authors: M
authors: Yoshida
authors: Akihiko
authors: A
authors: Saika
authors: Hideyo
authors: H
authors: Yoshida
authors: Takao
authors: T
authors: Suzuki
authors: Seizo
authors: S
authors: Yamamoto
authors: Hideaki
authors: H
authors: Ishibashi
authors: Hiroshi
authors: H
authors: Kawaguchi
authors: Kozo
authors: K
authors: Nakamura
authors: Toru
authors: T
authors: Akune
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000706:statistics & numerical data*; D015519:Bone Density / Q000502:physiology; D015331:Cohort Studies; D006233:Persons with Disabilities / Q000706:statistics & numerical data*; D005260:Female; D005843:Geography; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000453:epidemiology* / Q000503:physiopathology; D010024:Osteoporosis / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D012727:Sex Characteristics; D055009:Spondylosis / Q000453:epidemiology* / Q000503:physiopathology