Cell biology of the ESCRT machinery.
The ESCRT (endosomal sorting complex required for transport) machinery comprises a set of protein complexes that regulate sorting and trafficking into multivesicular bodies en route to the lysosome. The physical mechanism responsible for generating lumenal vesicles in this pathway is unknown. Here we review recent studies suggesting that components of the ESCRT-III complex drive lumenal vesicle formation and consider possible mechanisms for this reaction.
Hanson
Phyllis I
PI
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. phanson22@wustl.edu
Shim
Soomin
S
Merrill
Samuel A
SA
D000818:Animals; D001105:Archaea / Q000378:metabolism; D001692:Biological Transport; D048749:Cytokinesis; D003593:Cytoplasm / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D025801:Ubiquitin / Q000737:chemistry; D033921:Vesicular Transport Proteins / Q000378:metabolism
D011108:Polymers; D025801:Ubiquitin; D033921:Vesicular Transport Proteins