Chromosome segregation: monopolin goes spindle.
At anaphase onset the mitotic spindle undergoes dramatic changes in order to segregate sister chromatids. Surprisingly, the monopolin complex, best known for its role at kinetochores in meiosis, is now shown to localize to, and stabilize, the mitotic anaphase spindle.
Khmelinskii
Anton
A
Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Im Neuenheiemer Feld 282, 69117 Heidelberg, Germany.
Schiebel
Elmar
E
D018797:Cell Cycle Proteins / Q000378:metabolism*; D020090:Chromosome Segregation; D008870:Microtubules / Q000378:metabolism; D046912:Multiprotein Complexes / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000166:cytology / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
C474335:CSM1 protein, S cerevisiae; D018797:Cell Cycle Proteins; C474336:LRS4 protein, S cerevisiae; C518266:Mam1 protein, S cerevisiae; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; C503885:CDC14 protein, S pombe; D010749:Phosphoprotein Phosphatases