Discoid lupus erythematosus in a patient with scleroderma and hepatitis C virus infection.
A 49-year-old Japanese woman presented with discoid lupus erythematosus (DLE) on the face. The presence of Raynaud's phenomenon, swollen fingers, a high anti-nuclear antibody titer, and the results of a biopsy revealed limited-type systemic sclerosis (lSSc). The association of SSc with DLE is rare, although some single case reports have been published in Japan. Our patient was positive for hepatitis C virus infection. Racial predisposition and immune imbalance are proposed to have played a role in the development of these lesions in our case.
Yamamoto
Mami
M
Department of Dermatology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. yamamoto-tki@umin.ac.jp
Yamamoto
Toshiyuki
T
Tsuboi
Ryoji
R
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis / Q000097:blood; D044466:Asian People; D001706:Biopsy; D004423:Ear / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006225:Hand / Q000294:innervation / Q000473:pathology / Q000503:physiopathology; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D007564:Japan; D008046:Lip / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D008179:Lupus Erythematosus, Discoid / Q000208:ethnology / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011928:Raynaud Disease / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000276:immunology* / Q000503:physiopathology
D000974:Antibodies, Antinuclear