Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine.
Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone. The patient died of metastatic disease 3 months after the diagnosis was made. The function of the renal graft was not affected at all. Renal transplant recipients are at high risk of developing nonmelanocytic skin tumors when on immunosuppressive therapy with cyclosporine A. Less common is the development of skin cancer during immunosuppression with azathioprine. Latest reports show the increased incidence of malignant melanoma in immunosuppressed patients. Our case illustrates the necessity of close dermatological surveillance of allograft recipients, to assure an early recognition of any malignant skin tumor and to reduce the risk of systemic metastatic disease.
Guenova
Emmanuella
E
Department of Dermatology, Eberhard Karls University, Liebermeister Strasse, 25, Tuebingen, Germany.
Lichte
Verena
V
Hoetzenecker
Wolfram
W
Woelbing
Florian
F
Moehrle
Matthias
M
Roecken
Martin
M
Schaller
Martin
M
D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000209:etiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D055088:Early Detection of Cancer; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016030:Kidney Transplantation; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000209:etiology* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D013160:Splenic Neoplasms / Q000556:secondary; D000077204:Temozolomide
D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents; D003606:Dacarbazine; D001379:Azathioprine; D000077204:Temozolomide