title: How is adrenocortical cancer being managed in the UK?
abstract: BACKGROUND
  Adrenocortical carcinomas are rare. This case series is reported to give an overview of how adrenocortical carcinoma is currently managed in the UK.
  
  
  METHODS
  A retrospective review was made of case notes from patients with adrenocortical carcinomas presenting to the authors (TWJL, RDB, BJH, and DS-C) over the past 10 years in Newcastle, Sheffield and Cardiff.
  
  
  RESULTS
  Newcastle treated twelve, Sheffield eleven and Cardiff seven cases. The median follow-up was 25.5 months (range, 1-102 months). All tumours were greater than 5 cm in diameter. The majority presented with symptoms of hormone excess. Adrenalectomy was performed in 83% - this was radical in 30% and followed by excision of recurrence in 13%. Adjuvant mitotane was given in 64% of patients, in combination with cytotoxic chemotherapy in 20%. One-third of patients did not receive any adjuvant therapy. There was no significant difference in survival between the three centres. The majority of patients (57%) died during the period of follow-up of this study. The median survival was 37 months (range, 2-102 months).
  
  
  CONCLUSIONS
  The size of tumour, stage and mode of presentation, age and overall survival of patients in this study are comparable to published series of adrenocortical carcinomas from major endocrine surgical centres world-wide. Despite controversies about benefits, adjuvant mitotane was used in the majority of cases, whereas cytotoxic chemotherapy was only used in the minority. The exact role of adjuvant therapy in the management of adrenocortical carcinoma is not as well established as for other more common malignancies. Establishing a database for adrenocortical carcinomas in the UK would contribute to our understanding of the management of this disease.
authors: Department of Surgery, North Tyneside General Hospital, North Shields, UK.
authors: Sebastian R
authors: SR
authors: Aspinall
authors: A H
authors: AH
authors: Imisairi
authors: R D
authors: RD
authors: Bliss
authors: D
authors: D
authors: Scott-Coombes
authors: B J
authors: BJ
authors: Harrison
authors: T Wj
authors: TW
authors: Lennard
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D000315:Adrenalectomy / Q000379:methods; D018268:Adrenocortical Carcinoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols; D017024:Chemotherapy, Adjuvant; D003603:Cytotoxins / Q000627:therapeutic use; D006801:Humans; D008939:Mitotane / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D016019:Survival Analysis; D006113:United Kingdom
chemical_list: D018931:Antineoplastic Agents, Hormonal; D003603:Cytotoxins; D008939:Mitotane