title: Solution-phase parallel synthesis of a multi-substituted benzo[b]thiophene library.
abstract: Generation of a library using parallel syntheses of multi-substituted benzo[b]thiophenes is described. The requisite 3-iodobenzo[b]thiophenes are readily prepared in excellent yields from various alkynes bearing electron-rich aromatic rings by electrophilic cyclization using I(2) in CH(2)Cl(2). The heteroaromatic carbon-iodine bonds allow further diversification by palladium-catalyzed Suzuki-Miyaura, Sonogashira, Heck, and carboalkoxylation chemistry to give multi-substituted benzo[b]thiophene derivatives.
authors: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors: Chul-Hee
authors: CH
authors: Cho
authors: Benjamin
authors: B
authors: Neuenswander
authors: Gerald H
authors: GH
authors: Lushington
authors: Richard C
authors: RC
authors: Larock
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D010165:Palladium / Q000737:chemistry; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D013876:Thiophenes; C088015:benzothiophene; D010165:Palladium