Epigenetic influences on brain development and plasticity.
A fine interplay exists between sensory experience and innate genetic programs leading to the sculpting of neuronal circuits during early brain development. Recent evidence suggests that the dynamic regulation of gene expression through epigenetic mechanisms is at the interface between environmental stimuli and long lasting molecular, cellular and complex behavioral phenotypes acquired during periods of developmental plasticity. Understanding these mechanisms may give insight into the formation of critical periods and provide new strategies for increasing plasticity and adaptive change in adulthood.
Fagiolini
Michela
M
F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, CLS 13034, Boston, MA 02115, United States.
Jensen
Catherine L
CL
Champagne
Frances A
FA
D000375:Aging / Q000235:genetics / Q000502:physiology; D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000502:physiology; D003423:Critical Period, Psychological; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009473:Neuronal Plasticity / Q000235:genetics* / Q000502:physiology; D009435:Synaptic Transmission / Q000235:genetics / Q000502:physiology