Pentosidine - a new biochemical marker in diabetic retinopathy.
OBJECTIVE
This study was done to evaluate the role of pentosidine in predicting the progression of diabetic retinopathy.


METHODS
We included 30 subjects with insulin-dependent diabetes mellitus (type 1) and 10 healthy control individuals. A case control study was done. Full ophthalmological examination together with laboratory investigations (blood glucose level, HbA(1C) and blood pentosidine level corrected to blood total protein values were measured) were done in all subjects included in this study. The level of pentosidine was correlated with the duration of diabetes and the stage of retinopathy. All data were analyzed and reported.


RESULTS
Significant elevation of pentosidine was found in patients during the earliest detectable phase of diabetic retinopathy (early nonproliferative diabetic retinopathy) and more elevation at the preproliferative stage of retinopathy, returning to lower levels at the proliferative stage of diabetic retinopathy.


CONCLUSIONS
Pentosidine can be used as a biochemical marker for early occurrence of diabetic retinopathy and as an alarming factor in the preproliferative stage of diabetic retinopathy, thus helping decrease ocular complications.
Salman
Abdelrahman Gaber
AG
Department of Ophthalmology, Ain Shams University, Cairo, Egypt. ab_gab@hotmail.com
Mansour
Dina Ezzat Abdel Aziz
DE
Swelem
Al-Hussein Ali
AH
Al-Zawahary
Walid Mohamed Abdel-Raaouf
WM
Radwan
Ahmad Abdelmegid
AA
D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000097:blood* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D017127:Glycation End Products, Advanced / Q000097:blood; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000097:blood; D008297:Male; D008875:Middle Aged
D001120:Arginine; D015415:Biomarkers; D001786:Blood Glucose; D001798:Blood Proteins; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D008239:Lysine; C517652:hemoglobin A1c protein, human; C062187:pentosidine