title: Liver perfusion with dynamic multidetector-row computed tomography as an objective method to evaluate the efficacy of chemotherapy in patients with colorectal cancer.
abstract: A total of 24 liver metastases of colorectal cancer were evaluated by dynamic multiphasic CT. Under chemotherapy, follow-up examinations were performed every 3 months. The tumor marker CEA before vs. after chemotherapy correlated with the mean contrast enhancement within the margin of metastases. The total size of metastases correlated with the size of central necrosis as well as with the size of marginal contrast enhancement. CT is able to quantify perfusion and local activity of liver metastases to determine the efficacy of chemotherapy.
authors: Department of Diagnostic and Interventional Radiology, University Hospitals of Ulm, Ulm, Germany. sandra.pauls@uni-ulm.de
authors: Sandra
authors: S
authors: Pauls
authors: Andreas
authors: A
authors: Gabelmann
authors: Wolfgang
authors: W
authors: Heinz
authors: Eckhart
authors: E
authors: Fröhlich
authors: Markus Sebastian
authors: MS
authors: Juchems
authors: Hans-Jürgen
authors: HJ
authors: Brambs
authors: Stefan Andreas
authors: SA
authors: Schmidt
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging*; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D055420:Perfusion Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents