Antenatal corticosteroids increase fetal, but not postnatal, pulmonary blood flow in sheep.
The lungs of very preterm infants have immature airways and gas exchange structures and are usually surfactant deficient. Antenatal corticosteroids are commonly used to enhance fetal lung maturation in preterm infants, but little is known of their effects on pulmonary blood flow (PBF) before and immediately after birth. Our aim was to determine the effects of antenatal betamethasone on PBF before birth and during the postnatal transition in very preterm lambs. Antenatal betamethasone treatment significantly increased mean fetal PBF from 20.2 +/- 5.1 to 84.3 +/- 18.3 mL/min at 30 h after administration; the PBF waveform was also significantly altered. Mean diastolic PBF increased from -38.5 +/- 4.9 pretreatment to -10.2 +/- 11.0 mL/min at approximately 36 h after the initial betamethasone dose (negative values indicate retrograde flow away from the lungs). Within 10 min after delivery, PBF was similar in control and betamethasone-treated lambs. These data demonstrate that antenatal betamethasone significantly increases fetal PBF and alters the PBF waveform but has little effect on postnatal PBF.
Crossley
Kelly J
KJ
Department of Physiology, Monash University, Clayton, Victoria 3800, Australia. kelly.crossley@med.monash.edu.au
Morley
Colin J
CJ
Allison
Beth J
BJ
Davis
Peter G
PG
Polglase
Graeme R
GR
Wallace
Megan J
MJ
Zahra
Valerie A
VA
Hooper
Stuart B
SB
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001623:Betamethasone / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology*; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D011247:Pregnancy; D011651:Pulmonary Artery / Q000378:metabolism; D011652:Pulmonary Circulation / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects*; D012756:Sheep; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D005938:Glucocorticoids; D042461:Vascular Endothelial Growth Factor A; D001623:Betamethasone; D052250:Nitric Oxide Synthase Type III