Molecular analysis and implications of neurovirulent circulating vaccine-derived poliovirus in Jamaica. A case report and review of literature.
As the goal to eradicate wild polio virus (WPV) is approached, outbreaks associated with vaccine derived polioviruses (VDPV) with neurovirulent properties have emerged. The relevance for the spread of infection by nonparalytic cVDPV cases, with mutations associated with neurovirulence, is discussed with reference to the molecular analysis of a VDPV isolated from a Jamaican child who presented with aseptic meningitis. Potential risks to the Jamaican community resulting from circulation of cVDPV and critical factors defined by the World Health Organization (WHO) in the global eradication of Polio are analyzed in the context of immunization coverage, and the need to stop all Oral Polio Vaccine (OPV) use once wild polioviruses (WPVs) have been eradicated.
Jackson
S T
ST
Department of Micobiology, The University of the West Indies, Kingston 7, Jamaica, West Indies. Sandra.jacksonbetty@uwimona.edu.jm
Mullings
A M
AM
Booth
T F
TF
MacDonald
L
L
Henry
S O
SO
Khan
C A
CA
McLaughlin
P D
PD
D002675:Child, Preschool; D006801:Humans; D017589:Immunization Programs; D007563:Jamaica; D008297:Male; D011051:Poliomyelitis / Q000453:epidemiology* / Q000517:prevention & control*; D017955:Poliovirus / Q000472:pathogenicity; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D014611:Vaccination / Q000009:adverse effects*
D011055:Poliovirus Vaccine, Oral