title: Surveillance of infectious complications in hemato-oncological patients.
abstract: BACKGROUND
  Monitoring the rate of infections in individual centers that treat patients with hematological malignancies is of major importance. However, there are no uniform guidelines for infection surveillance.
  
  
  OBJECTIVE
  To describe the epidemiology of bacterial and fungal infections in a single hematology ward and to compare methods for reporting surveillance and infection rates in other centers in Israel.
  
  
  METHODS
  We conducted a prospective surveillance of all patients admitted to our hematology ward, applying standard definitions for invasive fungal infections and adapting definitions for non-fungal infections. Incidence rates were calculated using patients, admissions, hospital days and neutropenia days. We performed a search for other reported surveillance studies in Israel. ,
  
  
  RESULTS
  We detected 79 infectious episodes among 159 patients admitted to the hematology ward during 1 year. Using neutropenia days as the denominator for calculation of incidence discriminated best between patients at high and low risk for infection. The incidence of invasive fungal infections was 7, 10 and 18 per 1000 neutropenia days, among all patients, those with acute leukemia and those with acute leukemia undergoing induction therapy, respectively. Only 10 reports from Israel were identified, 6 of which were prospective. Our data could not be compared to these reports because of the varying definitions and denominators used.
  
  
  CONCLUSIONS
  Hematology centers should monitor infection rates and report them in a uniform methodology.
authors: Institute of Hematology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel.
authors: Ron
authors: R
authors: Ram
authors: Anat
authors: A
authors: Gafter-Gvili
authors: Pia
authors: P
authors: Raanani
authors: Moshe
authors: M
authors: Yeshurun
authors: Ofer
authors: O
authors: Shpilberg
authors: Juliet
authors: J
authors: Dreyer
authors: Anat
authors: A
authors: Peck
authors: Leonard
authors: L
authors: Leibovici
authors: Mical
authors: M
authors: Paul
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000150:complications / Q000453:epidemiology*; D002173:Cancer Care Facilities; D003428:Cross Infection / Q000453:epidemiology*; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000150:complications / Q000453:epidemiology*; D011159:Population Surveillance; D011446:Prospective Studies