title: Silicon-on-Insulator microring resonator for sensitive and label-free biosensing.
abstract: Label-free biosensors attempt to overcome the stability and reliability problems of biosensors relying on the detection of labeled molecules. We propose a label-free biosensor based on microring cavities in Silicon-on-Insulator (SOI) that fits in an area below 10x10mum(2). The resonance wavelength shift that occurs when the surroundings of a cavity is changed, is used for sensing. While theoretically the performance for bulk refractive index changes is moderate (10(-5)), this device performs outstanding in terms of absolute molecular mass sensing (theoretical sensitivity of 1fg molecular mass) thanks to its extremely small dimensions. We use the avidin/biotin high affinity couple to demonstrate good repeatability and detection of protein concentrations down to 10ng/ml. Fabrication with Deep UV lithography allows for cheap mass production and integration with electronic functions for complete lab-on-chip devices.
authors: Katrien
authors: K
authors: De Vos
authors: Irene
authors: I
authors: Bartolozzi
authors: Etienne
authors: E
authors: Schacht
authors: Peter
authors: P
authors: Bienstman
authors: Roel
authors: R
authors: Baets