Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample.
Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P=0.01) and rs3918342 (P=0.02), and a highly significant under-transmission between haplotype CAT (P=0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.
Ma
Jie
J
Department of Genetics and Molecular Biology, Xi'an Jiaotong University School of Medicine, 76 West Yan Ta Rd., Xi'an, Shaanxi, PR China.
Sun
Jian
J
Zhang
Huan
H
Zhang
Rui
R
Kang
Wan-Hu
WH
Gao
Cheng-Ge
CG
Liu
Hai-Sheng
HS
Ma
Xue-Hong
XH
Min
Zi-Xin
ZX
Zhao
Wen-Xiang
WX
Ning
Qi-Lan
QL
Wang
Shu-Hong
SH
Zhang
Yin-Cang
YC
Guo
Ting-Wei
TW
Lu
She-Min
SM
D000328:Adult; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
D002352:Carrier Proteins; C475071:DAOA protein, human; D047908:Intracellular Signaling Peptides and Proteins