[Hepatobiliary transport of glutathione and its role in cholestasis].
Glutathione is a tripeptide comprised by L-glutamate, L-cysteine, and glycine, that serves antioxygenation and deintoxication functions within the cell. Recent study has found that glutathione is the main driving force for bile salt-independent bile flow, impaired biliary excretion of glutathione can lead to cholestasis. This review focuses on hepatobiliary transport of glutathione and its role in cholestasis. Based on the evidence of choleretic effect of glutathione, enhancement of biliary excretion of glutathione may be a good strategy for prevention and treatment of cholestasis.
Zhang
Xue-ying
XY
Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Yang
Jin
J
Yin
Xue-fen
XF
Liu
Xiao-dong
XD
Wang
Guang-ji
GJ
D000818:Animals; D001692:Biological Transport; D002779:Cholestasis / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D004967:Estrogens / Q000009:adverse effects; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D007566:Jaundice, Chronic Idiopathic / Q000235:genetics*; D008099:Liver / Q000378:metabolism*; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D010590:Phalloidine / Q000009:adverse effects; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D004967:Estrogens; D005978:Glutathione; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010590:Phalloidine; D014580:Ursodeoxycholic Acid