title: DAMPs and inflammatory processes: the role of redox in the different outcomes.
abstract: Inflammation is deeply entangled with redox modulation. Triggering of PRRs on inflammatory cells induces ROS generation. As a consequence, activated cells mount antioxidant responses to counteract the possible harmful effects of oxidation. Therefore, when repair is completed, homeostasis is restored. Here, we describe some recent results showing that an exuberant antioxidant response to pro-oxidant inflammatory stimuli modifies not only the intra- but also the extracellular redox and contributes to the outcome of the inflammatory process. In particular, the role of redox modulation in IL-1beta secretion, in B lymphocyte differentiation to plasma cells, and in tumor progression will be discussed, and the potential consequences of extracellular redox alterations on DAMP activity will be considered.
authors: Cell Biology Unit, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy.
authors: Sonia
authors: S
authors: Carta
authors: Patrizia
authors: P
authors: Castellani
authors: Laura
authors: L
authors: Delfino
authors: Sara
authors: S
authors: Tassi
authors: Roberta
authors: R
authors: Venè
authors: Anna
authors: A
authors: Rubartelli
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000378:metabolism; D008954:Models, Biological; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D018836:Inflammation Mediators; D017382:Reactive Oxygen Species