Epstein-Barr virus antibody level and gastric cancer risk in Korea: a nested case-control study.
BACKGROUND
Few cohort studies have investigated Epstein-Barr virus (EBV) infection before the occurrence of gastric cancer.


METHODS
Among 14,440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein-Barr virus antibodies IgG and IgA against viral capsid antigen (VCA), EBV nuclear antigen (EBNA) antibody IgG, and early antigen (EA) antibody IgG were measured using enzyme immunoassays (EIAs).


RESULTS
The highest titres of VCA IgG (odds ratio (OR): 1.37, 95% confidence interval (CI): 0.62-3.06) or EBNA IgG (OR: 0.87, 95% CI: 0.51-1.46) were not associated with gastric cancer risk.


CONCLUSIONS
Higher levels of VCA IgG or EBNA IgG were not associated with increased risk of gastric adenocarcinoma in Koreans.
Kim
Y
Y
Cancer Early Detection Branch, National Cancer Control Research Institute, National Cancer Center, 111 Jungbalsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-769, Korea.
Shin
A
A
Gwack
J
J
Ko
K-P
KP
Kim
C-S
CS
Park
S K
SK
Hong
Y-C
YC
Kang
D
D
Yoo
K-Y
KY
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D036022:Capsid Proteins / Q000276:immunology; D016022:Case-Control Studies; D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000209:etiology / Q000821:virology*
D000914:Antibodies, Viral; D036022:Capsid Proteins; D019309:Epstein-Barr Virus Nuclear Antigens; D007074:Immunoglobulin G