[Management of pseudoexfoliative glaucoma in a tertiary center in Romania].
OBJECTIVE
To analyze the course of the disease and the management of patients with pseudoexfoliative glaucoma in our clinic, a tertiary center for glaucoma.


METHODS
Retrospective chart review of patients admitted in the last 8 years (2000-2007).


RESULTS
We have collected data concerning 330 eyes (238 patients). The mean follow-up period was 13.85 +/- 11.03 months (limits 0.5-91 months). The mean visual acuity was 0.31 +/- 0.33 and did not alter significantly. The mean initial IOP was 27.25 +/- 13.64 mmHg (50% of eyes were already under treatment, receiving an average of 1.66 +/- 0.72 drugs). During the follow-up period 66.66% of eyes were subject to antiglaucoma surgery. The mean interval from diagnosis to surgery was 10.24 +/- 23.34 months. The final IOP was significantly decreased to 17.02 +/- 7.77 mmHg (68.96% of eyes were receiving topical antiglaucoma therapy, the mean number of drugs being 1.57 +/- 0.71). The C/D ratio increased from 0.76 +/- 0.26 to 0.81 +/- 0.24 (p = 0.01). In automated perimetry the mean deviation increased from 17.13 +/- 11.68 to 17.51 +/- 10.83 (the increase was not significant, p = 0.87). The pattern standard deviation increased from 5.92 +/- 3.83 to 6.16 +/- 3.19 (p = 0.63). A number of 75 patients (31.51%) had cardiovascular diseases, most frequently arterial hypertension (27.31%) and myocardial ischemia (9.66%).


CONCLUSIONS
A large proportion of our pseudoexfoliative glaucoma patients needed antiglaucoma surgery. Even after surgery, about 2/3 of eyes were still under topical therapy. Under this management, we have noted a progression of the C/D ratio, but not of the visual field parameters during the follow-up period.
Danielescu
C
C
Clinica i Oftalmologie, Iaşi.
D000046:Academic Medical Centers; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D017889:Exfoliation Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D012189:Retrospective Studies; D012383:Romania; D016896:Treatment Outcome; D014792:Visual Acuity; D058609:Visual Field Tests / Q000379:methods
D000959:Antihypertensive Agents