Pilot study of association of anembryonic pregnancy with 55 elements in the urine, and serum level of folate, homocysteine and S-adenosylhomocysteine in Shanxi Province, China.
OBJECTIVE
To estimate the association of anembryonic pregnancy with 55 elements, homocysteine, folate and S-adenosylhomocysteine in pregnant women.


METHODS
Thirty cases of anembryonic pregnancy were diagnosed using ultrasound scanning that showed an empty gestation sac with no embryo pole in the uterus. Additionally, thirty women with normal pregnancy were followed through the delivery a live and normal baby. The cases and controls were matched by age and week of gestation. Levels of 55 elements, homocysteine, folate and S-adenosylhomocysteine in women with anembryonic pregnancies were compared with those of the women experiencing normal pregnancies.


RESULTS
Women with anembryonic pregnancies had statistically significantly lower levels of folate and 10 elements including V, Ti, Li, Cd, Sr, Rb, P, Na, K, and B than did women experiencing normal pregnancies. However, they had higher homocysteine and Ge levels than did the controls.


CONCLUSIONS
The levels of multiple nutrients including folate, 11 elements and homocysteine may be associated with the risk of anembryonic pregnancy.
Yin
Yan
Y
Peking Union Medical College, Capital Institute of Pediatric, Peking University, Beijing, China.
Zhang
Ting
T
Dai
Yaohua
Y
Zheng
Xiaoying
X
Pei
Lijun
L
Lu
Xiaolin
X
D000328:Adult; D016022:Case-Control Studies; D002681:China; D005260:Female; D005492:Folic Acid / Q000097:blood*; D005865:Gestational Age; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D015999:Multivariate Analysis; D009752:Nutritional Status; D010865:Pilot Projects; D011247:Pregnancy / Q000097:blood / Q000652:urine; D011256:Pregnancy Outcome; D012435:S-Adenosylhomocysteine / Q000097:blood*; D014131:Trace Elements / Q000097:blood* / Q000652:urine; D014556:Urine / Q000737:chemistry*; D055815:Young Adult
D014131:Trace Elements; D006710:Homocysteine; D005492:Folic Acid; D012435:S-Adenosylhomocysteine