title: Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potential.
abstract: Syntheses of 3,3-diheteroaromatic oxindole derivatives has been achieved by coupling indole-2,3-dione (isatin) with differently substituted indoles and pyrrole in presence of I(2) in i-PrOH. The in vitro spermicidal potentials and the mode of spermicidal action of the synthesized analogues were evaluated and the derivative, 3,3-bis (5-methoxy-1H-indol-3-yl) indolin-2-one (3d) exhibited most significant activity.
authors: Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Jadavpur, Kolkata 700 032, India.
authors: Priyankar
authors: P
authors: Paira
authors: Abhijit
authors: A
authors: Hazra
authors: Shrabanti
authors: S
authors: Kumar
authors: Rupankar
authors: R
authors: Paira
authors: Krishnendu B
authors: KB
authors: Sahu
authors: Subhendu
authors: S
authors: Naskar
authors: Pritam
authors: P
authors: Saha
authors: Shyamal
authors: S
authors: Mondal
authors: Arindam
authors: A
authors: Maity
authors: Sukdeb
authors: S
authors: Banerjee
authors: Nirup B
authors: NB
authors: Mondal
mesh_terms: D000818:Animals; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D046529:Microscopy, Electron, Transmission; D000078183:Oxindoles; D051381:Rats; D013089:Spermatocidal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C543971:3,3-bis(5-methoxy-1H-indol-3-yl)indolin-2-one; D007211:Indoles; D000078183:Oxindoles; D013089:Spermatocidal Agents; C022960:2-oxindole