Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity.
Telomerase is almost universally required for cellular immortality and is permissive for tumorigenesis. Accumulating evidence suggests that telomerase may have roles in cellular processes independent of its role in telomere maintenance. However, the biochemical properties and the mechanisms of telomerase non-telomeric functions are unknown. In this report, we show that the telomerase catalytic component hTERT is capable of activating transcription of VEGF. We further demonstrated that the activation of VEGF expression by hTERT was independent of telomerase activity and telomere maintenance. These results suggest that hTERT has non-telomeric activity in the regulation of gene expression and provide additional insights into the role of telomerase in aging and cancer.
Zhou
Lili
L
Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, 19 Xin Jie Kou Wai Avenue, Beijing 100875, China.
Zheng
Danhua
D
Wang
Miao
M
Cong
Yu-Sheng
YS
D002384:Catalysis; D002460:Cell Line; D004730:Endothelium, Vascular / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D019098:Telomerase / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
D042461:Vascular Endothelial Growth Factor A; D019098:Telomerase