A 13-week subchronic oral toxicity study of L-serine in rats.
A subchronic oral toxicity study was conducted to evaluate the safety of L-serine in Sprague-Dawley rats. The test article was administered once daily by gavage in male and female rats at dose levels of 0, 500, 1500, and 3000 mg/kg body weight/day for 13 weeks. Daily clinical signs, body weight, and food consumption were not affected by ingestion of the test article. There were no treatment-related adverse effects on urinalysis, hematology, serum biochemistry, organ weights, gross and histopathological examination. It was concluded that the no-observed-effect level (NOEL) for L-serine was 3000 mg/kg bw/day for both genders.
Kaneko
I
I
FANCL Research Institute, Yokohama, Japan. izkaneko@fancl.co.jp
Han
L
L
Liu
T
T
Li
J
J
Zhao
Y
Y
Li
C
C
Yi
Y
Y
Liang
A
A
Hayamizu
K
K
D000284:Administration, Oral; D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D005503:Food Additives / Q000633:toxicity*; D006403:Hematologic Tests; D008136:Longevity / Q000187:drug effects; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012694:Serine / Q000633:toxicity*; D016482:Urinalysis
D005503:Food Additives; D012694:Serine