title: Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation.
abstract: BACKGROUND
  Oxidative stress is associated with atrial fibrillation (AF). However, little is known about the relationship between serum markers of oxidation and electrical activity in patients with AF.
  
  
  OBJECTIVE
  The purpose of this study was to investigate the possible association between serum markers of reactive oxidative metabolism and atrial remodeling in paroxysmal and persistent AF.
  
  
  METHODS
  Derivatives of reactive oxidative metabolites (DROM), an index of oxidative stress, were measured in 306 consecutive patients with AF (225 paroxysmal, 81 persistent) undergoing radiofrequency (RF) catheter ablation. Filtered P-wave duration by P-wave signal-averaged ECG and levels of high-sensitivity C-reactive protein (CRP) as an inflammatory marker also were measured.
  
  
  RESULTS
  Patients were followed up for 1.2 +/- 0.8 years. DROM levels in patients with persistent AF were significantly higher than in patients with paroxysmal AF (341.6 +/- 85.5 Carratelli [Carr] units vs 305.0 +/- 77.7 Carr units, P <.001). DROM levels showed a tighter, positive correlation with filtered P-wave duration in persistent AF patients (r = 0.56, P <.001) than in all AF patients (r = 0.13, P <.05). DROM levels also showed a weaker but significant correlation with high-sensitivity CRP in patients with AF. Kaplan-Meier analysis revealed that the highest quartile of basal DROM levels exhibited a significantly higher AF recurrence rate after RF catheter ablation in patients with paroxysmal AF (P <.01).
  
  
  CONCLUSIONS
  Serum markers of oxidative stress reflect atrial conduction disturbance and predict AF recurrence after RF catheter ablation in paroxysmal AF patients. DROM could serve as a biomarker for predicting risk of AF recurrence after RF catheter ablation.
authors: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Masayuki
authors: M
authors: Shimano
authors: Rei
authors: R
authors: Shibata
authors: Yasuya
authors: Y
authors: Inden
authors: Naoki
authors: N
authors: Yoshida
authors: Tomohiro
authors: T
authors: Uchikawa
authors: Yukiomi
authors: Y
authors: Tsuji
authors: Toyoaki
authors: T
authors: Murohara
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000378:metabolism / Q000503:physiopathology*; D015415:Biomarkers; D005260:Female; D006325:Heart Atria / Q000378:metabolism / Q000503:physiopathology; D006329:Heart Conduction System / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species