[Common variable immunodeficiency: report of two cases and literature review].
OBJECTIVE
To promote the awareness of common variable immunodeficiency (CVID).


METHODS
Report two cases of CVID and review related literature.


RESULTS
The two CVID patients were manifested recurrent infections of respiratory and digestive tract, splenomegaly, significantly reduced serum immunoglobulin, since adolescence. They were treated with intravenous gammaglobulin, anti-infection and symptomatic therapies and the diseases were well controlled. Case 1 was diagnosed as with spleen peripheral T cell lymphoma after splenectomy. Case 2 developed nutritional megaloblastic anemia resulting from repeated digestive tract infections.


CONCLUSIONS
CVID is a heterogeneous group of diseases with later-onset, characterized by hypogammaglobulinemia and recurrent bacterial infections. Early diagnosis and regular treatment may improve the prognosis.
Li
Jian-ping
JP
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
Wang
Hui-jun
HJ
Zhang
Lei
L
Yang
Ren-chi
RC
Zhang
Feng-kui
FK
D017074:Common Variable Immunodeficiency / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult