On the emerging role of chemistry in the fashioning of biologics: synthesis of a bidomainal fucosyl GM1-based vaccine for the treatment of small cell lung cancer.
The synthesis of the novel small cell lung cancer (SCLC) fucosyl GM1-based vaccine construct, featuring insertion of the HLA-DR binding 15 amino acid sequence derived from Plasmodium falciparum, is described. The resultant glycopeptide has been synthesized in an efficient manner. Finally, successful conjugation of the glycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein completed the preparation of the vaccine.
Nagorny
Pavel
P
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.
Kim
Woo Han
WH
Wan
Qian
Q
Lee
Dongjoo
D
Danishefsky
Samuel J
SJ
D019496:Cancer Vaccines / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology*; D018288:Carcinoma, Small Cell / Q000628:therapy*; D005677:G(M1) Ganglioside / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D018074:Vaccines, Conjugate / Q000737:chemistry / Q000276:immunology*
D019496:Cancer Vaccines; D018074:Vaccines, Conjugate; D005677:G(M1) Ganglioside; C039123:fucosyl GM1 ganglioside