title: What are the roles of microRNAs at the mammalian synapse?
abstract: The modification of neuronal connections in response to stimuli is believed to be the basis of long-term memory formation. It is currently accepted that local protein synthesis critically contributes to site-restricted modulation of individual synapses. Here, we summarize recent evidence implicating miRNAs in this process, leading to altered dendrite morphogenesis and synaptic plasticity. Second, we discuss findings in non-neuronal systems about how RNA-binding proteins can modulate miRNA-mRNA interactions, and how these mechanisms might apply to neurons. Finally, we review recent findings that P-bodies may be important sites for miRNA action at the synapse.
authors: Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria.
authors: Anetta
authors: A
authors: Konecna
authors: Jacki E
authors: JE
authors: Heraud
authors: Lucia
authors: L
authors: Schoderboeck
authors: Alexandre A S F
authors: AA
authors: Raposo
authors: Michael A
authors: MA
authors: Kiebler
mesh_terms: D000818:Animals; D003712:Dendrites / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000033:anatomy & histology* / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology*; D008954:Models, Biological; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D035683:MicroRNAs