Critical illness polyneuropathy after Bacillus cereus sepsis in acute lymphoblastic leukemia.
We report a 16-year-old woman patient with acute lymphoblastic leukemia (ALL) who developed severe critical illness polyneuropathy (CIP). She developed Bacillus cereus sepsis with multiple brain abscesses after chemotherapy. Although she was successfully treated and her general condition recovered, she could not stand. CIP was diagnosed based on the clinical course and electrophysiological studies. Since vincristine (VCR) was thought to have aggravated neurological symptoms, ALL treatment was continued without VCR. Five months from the onset of CIP, she could walk again with steppage gait. This case suggests that CIP can recover even while continuing ALL treatment, but omitting VCR.
Nishikawa
Takuro
T
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences. adu44150@ams.odn.ne.jp
Okamoto
Yasuhiro
Y
Tanabe
Takayuki
T
Kodama
Yuichi
Y
Shinkoda
Yuichi
Y
Kawano
Yoshifumi
Y
D000293:Adolescent; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects; D016863:Bacillaceae Infections / Q000209:etiology*; D001409:Bacillus cereus; D001922:Brain Abscess / Q000209:etiology; D055724:Electrophysiological Phenomena; D005260:Female; D006801:Humans; D011115:Polyneuropathies / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D018805:Sepsis / Q000209:etiology*; D014750:Vincristine / Q000009:adverse effects
D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine