title: Chronic alcohol consumption from adolescence-to-adulthood in mice--effect on growth and social behavior.
abstract: Experimentation with alcohol is common during adolescence. However the long-term consequences from moderate alcohol use during adolescence development are not clear. Using a two-bottle free-choice paradigm in the home-cage setting, we studied adolescent mice (4 weeks old) across a 6-week time span of the adolescence-to-adulthood development period. Adolescent mice readily reached a steady level of alcohol consumption and maintained this level throughout the 6-week period. Chronic alcohol consumption resulted in reduced growth in adolescent mice, as well as accelerated acclimation to a novel environment. During a social interaction test, similar levels of initial social investigation and subsequent habituation were observed in both the chronic alcohol and the water-only control groups. However, chronic alcohol self-administration resulted in impaired social recognition and decreased social play/fight behavior. Taken together, these results indicated that chronic alcohol consumption across adolescence development negatively impacted both physical growth and social behavior in mice, highlighting the detrimental consequences from prolonged alcohol drinking in adolescence.
authors: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors: Hong
authors: H
authors: Zou
authors: Qinglian
authors: Q
authors: Xie
authors: Manfang
authors: M
authors: Zhang
authors: Chenghao
authors: C
authors: Zhang
authors: Guoping
authors: G
authors: Zhao
authors: Meilei
authors: M
authors: Jin
authors: Lei
authors: L
authors: Yu
mesh_terms: D000374:Aggression / Q000187:drug effects; D000375:Aging / Q000523:psychology*; D000428:Alcohol Drinking / Q000523:psychology*; D000818:Animals; D002755:Choice Behavior; D006128:Growth / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D021641:Recognition, Psychology / Q000187:drug effects; D012919:Social Behavior