title: The small heat shock protein, HSPB6, in muscle function and disease.
abstract: The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications.
authors: Capstone Therapeutics, Tempe, AZ 85281, USA. cparmiter@hotmail.com
authors: Catherine M
authors: CM
authors: Dreiza
authors: Padmini
authors: P
authors: Komalavilas
authors: Elizabeth J
authors: EJ
authors: Furnish
authors: Charles R
authors: CR
authors: Flynn
authors: Michael R
authors: MR
authors: Sheller
authors: Christopher C
authors: CC
authors: Smoke
authors: Luciana B
authors: LB
authors: Lopes
authors: Colleen M
authors: CM
authors: Brophy
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001249:Asthma / Q000378:metabolism; D050886:HSP20 Heat-Shock Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010748:Phosphopeptides; D051381:Rats; D015398:Signal Transduction; D013345:Subarachnoid Hemorrhage / Q000378:metabolism
chemical_list: D050886:HSP20 Heat-Shock Proteins; C494382:HSPB6 protein, human; D010748:Phosphopeptides