title: Growth faltering due to breastfeeding cessation in uninfected children born to HIV-infected mothers in Zambia.
abstract: BACKGROUND
  The effect of breastfeeding on growth in HIV-exposed infants is not well described.
  
  
  OBJECTIVE
  The objective was to evaluate the effect of early breastfeeding cessation on growth.
  
  
  METHODS
  In a trial conducted in Lusaka, Zambia, HIV-infected mothers were randomly assigned to exclusive breastfeeding for 4 mo followed by rapid weaning to replacement foods or exclusive breastfeeding for 6 mo followed by introduction of complementary foods and continued breastfeeding for a duration of the mother's choice. Weight-for-age z score (WAZ), length-for-age z score (LAZ), and weight-for-length z score (WLZ) and the self-reported breastfeeding practices of 593 HIV-uninfected singletons were analyzed. Generalized estimating equations were used to adjust for confounders.
  
  
  RESULTS
  WAZ scores declined precipitously between 4.5 and 15 mo. The decline was slower in the breastfed infants. At 9, 12, and 15 mo, mean WAZs were, respectively, -0.74, -0.92, and -1.06 in infants who were reportedly breastfed and were -1.07, -1.20, and -1.31 in the weaned infants (P = 0.003, 0.007, and 0.02, respectively). No differences were observed past 15 mo. Breastfeeding practice was not associated with LAZ, which declined from -0.98 to -2.24 from 1 to 24 mo. After adjustment for birth weight, maternal viral load, body mass index, education, season, and marital and socioeconomic status, not breastfeeding was associated with a 0.28 decline in WAZ between 4.5 and 15 mo (P < 0.0001). During the rainy season, not breastfeeding was associated with a larger WAZ decline (0.33) than during the dry season (0.22; P for interaction = 0.02).
  
  
  CONCLUSIONS
  Early growth is compromised in uninfected children born to HIV-infected Zambian mothers. Continued breastfeeding partially mitigates this effect through 15 mo. Nutritional interventions to complement breastfeeding after 6 mo are urgently needed. This trial was registered at clinicaltrials.gov as NCT00310726.
authors: Columbia University Gertrude H Sergievsky Center, College of Physicians and Surgeons and Mailman School of Public Health, New York, NY 10030, USA. sma2@columbia.edu
authors: Stephen
authors: S
authors: Arpadi
authors: Ashraf
authors: A
authors: Fawzy
authors: Grace M
authors: GM
authors: Aldrovandi
authors: Chipepo
authors: C
authors: Kankasa
authors: Moses
authors: M
authors: Sinkala
authors: Mwiya
authors: M
authors: Mwiya
authors: Donald M
authors: DM
authors: Thea
authors: Louise
authors: L
authors: Kuhn
mesh_terms: D000328:Adult; D000886:Anthropometry; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001942:Breast Feeding; D015331:Cohort Studies; D005183:Failure to Thrive / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006128:Growth / Q000502:physiology; D015658:HIV Infections / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000592:standards; D007227:Infant Nutritional Physiological Phenomena / Q000502:physiology*; D007231:Infant, Newborn / Q000254:growth & development*; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000503:physiopathology*; D012621:Seasons; D013997:Time Factors; D014886:Weaning; D015024:Zambia