title: Dysplastic kidneys in children - do they grow?
abstract: OBJECTIVE
  Dysplastic kidneys (DK) are a common cause of chronic kidney disease (CKD). Little is known about their growth or how their sonographic appearance changes. This study aimed to test the hypothesis that DK gain little length, and to identify radiologic trends predictive of CKD.
  
  
  METHODS
  Ultrasound scans of children with DK born in 1980-2005 and referred to a single tertiary centre were analysed by a pediatric radiologist. Renal lengths were plotted on standard nomograms and the degree of dysplastic appearance noted. Factors related to DK - bladder outlet obstruction, vesico-ureteric reflux and renal impairment - were noted.
  
  
  RESULTS
  Fifty-three children were studied (83 kidneys), of whom 41 were boys; 289 scans were analysed. In 33 children there was associated bladder outlet obstruction or vesico-ureteric reflux. Forty-four DK were noted to fall off their renal length 'centile'. This correlated well with the development of CKD and is statistically significant. Deterioration occurred in 53% of DK; primarily progressive reduction in corticomedullary differentiation. This also correlated well with development of CKD.
  
  
  CONCLUSIONS
  More than half of the DK showed poor growth velocity. This, together with the degree of sonographic abnormality, carries a high predictive value for development of CKD. We recommend diligent serial sonography to follow renal growth and dysplastic appearance in children with DK.
authors: Department of Paediatric Urology, Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus, Level E, East Block, Nottingham, UK. nia.fraser@ntlworld.com
authors: Nia
authors: N
authors: Fraser
authors: Anu
authors: A
authors: Paul
authors: A R
authors: AR
authors: Williams
authors: N
authors: N
authors: Broderick
authors: M U
authors: MU
authors: Shenoy
mesh_terms: D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000254:growth & development*; D007674:Kidney Diseases / Q000209:etiology; D008297:Male; D011237:Predictive Value of Tests; D014463:Ultrasonography