title: Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality.
abstract: In the past decade, palladium-catalyzed C-H activation/C-C bond-forming reactions have emerged as promising new catalytic transformations; however, development in this field is still at an early stage compared to the state of the art in cross-coupling reactions using aryl and alkyl halides. This Review begins with a brief introduction of four extensively investigated modes of catalysis for forming C-C bonds from C-H bonds: Pd(II)/Pd(0), Pd(II)/Pd(IV), Pd(0)/Pd(II)/Pd(IV), and Pd(0)/Pd(II) catalysis. A more detailed discussion is then directed towards the recent development of palladium(II)-catalyzed coupling of C-H bonds with organometallic reagents through a Pd(II)/Pd(0) catalytic cycle. Despite the progress made to date, improving the versatility and practicality of this new reaction remains a tremendous challenge.
authors: Chemical Development Department, Albany Molecular Research, Inc., 21 Corporate Circle, Albany, NY 12203, USA.
authors: Xiao
authors: X
authors: Chen
authors: Keary M
authors: KM
authors: Engle
authors: Dong-Hui
authors: DH
authors: Wang
authors: Jin-Quan
authors: JQ
authors: Yu
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D009942:Organometallic Compounds; D010165:Palladium