Regression of cardiac amyloid after autologous stem-cell transplantation.
Primary cardiac amyloid has a dismal prognosis and most treatments are experimental with highly variable results. Although autologous stem-cell transplant in conjunction with high-dose chemotherapy has yielded regression of amyloid in other body tissues, the presence of cardiac involvement contraindicates stem-cell transfer due to high treatment mortality. We describe the successful treatment of cardiac amyloid using autologous stem-cell transplantation and the resultant regression of the cardiac amyloid.
Blair
John E A
JE
Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Zeigler
Sanford M
SM
Mehta
Jayesh
J
Singhal
Seema
S
Cotts
William
W
D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000378:metabolism / Q000601:surgery*; D005260:Female; D006331:Heart Diseases / Q000378:metabolism / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D012074:Remission Induction; D033581:Stem Cell Transplantation; D016896:Treatment Outcome
D000682:Amyloid