title: Exogenous HIV-1 Vpr disrupts IFN-alpha response by plasmacytoid dendritic cells (pDCs) and subsequent pDC/NK interplay.
abstract: HIV Vpr is known for its immunomodulatory capacities including its impairment of NK cell functions. However, the role of pDCs in this context remains elusive. We show that synthetic Vpr substantially inhibits type I IFN production by pDCs without inducing apoptosis in pDCs. Furthermore, we found that exogenous Vpr compromises subsequent pDC/NK interplay as shown by diminished IFN-gamma production by NK cells. Thus, Vpr-mediated dysregulation of IFN-alpha and IFN-gamma production affects key components of the innate immune response supporting an essential role of Vpr in HIV pathogenesis.
authors: Clinic for Immunology und Rheumatology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover, Germany.
authors: Henoch Sangjoon
authors: HS
authors: Hong
authors: Nupur
authors: N
authors: Bhatnagar
authors: Matthias
authors: M
authors: Ballmaier
authors: Ulrich
authors: U
authors: Schubert
authors: Peter
authors: P
authors: Henklein
authors: Thorsten
authors: T
authors: Volgmann
authors: Hans
authors: H
authors: Heiken
authors: Reinhold E
authors: RE
authors: Schmidt
authors: Dirk
authors: D
authors: Meyer-Olson
mesh_terms: D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology; D016898:Interferon-alpha / Q000276:immunology* / Q000378:metabolism; D007371:Interferon-gamma / Q000276:immunology* / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D019899:Paracrine Communication; D054325:vpr Gene Products, Human Immunodeficiency Virus / Q000737:chemistry / Q000276:immunology* / Q000494:pharmacology
chemical_list: D007155:Immunologic Factors; D016898:Interferon-alpha; D054325:vpr Gene Products, Human Immunodeficiency Virus; C514912:vpr protein, Human immunodeficiency virus 1; D007371:Interferon-gamma