Early predictors of microvascular complications in type 1 diabetic patients.
OBJECTIVE
To investigate the possibility of depending on adiponectin and leptin as early predictors of microvascular complications in type 1 diabetic subjects.


METHODS
We studied 63 type 1 diabetic subjects from the National Institute of Diabetes (30 normoalbuminuric and 33 microalbuminuric). Clinical, demographic characteristics and kidney function tests were monitored. Plasma levels of adiponectin, leptin, interlukein-6 (IL-6), and the high sensitive C-reactive protein (CRP) were measured in these subjects.


RESULTS
Microalbuminuric subjects showed a significant elevation in adiponectin levels and a significant decrease in leptin levels as compared to normoalbuminuric subjects. Adiponectin showed a significant positive correlation with microalbuminuria concentrations while leptin showed a significant negative correlation with both fasting blood glucose and glycated hemoglobin A(1c).


CONCLUSIONS
The results of this study introduced the possibility of depending on adiponectin and leptin as early, reliable, and sensitive predictors for the microvascular complications monitored by microalbuminuria concentration and glycemic control indices.
Abd El-Maksoud
Awatif M
AM
Clinical Nutrition Department, National Nutrition Institute, Cairo, Egypt.
El Hefnawy
Mohammed H
MH
Yahya
Shaymaa M M
SM
Seoudi
Dina M
DM
Abdel-Ghaffar
Abdel-Rahman B
AR
Eskander
Emad F
EF
Ahmed
Hanaa H
HH
Kamal
Ibrahim H
IH
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000419:Albuminuria / Q000097:blood / Q000150:complications / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D042241:Early Diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005215:Fasting / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007677:Kidney Function Tests; D020738:Leptin / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D012044:Regression Analysis; D014652:Vascular Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis
D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D015850:Interleukin-6; D020738:Leptin