Cushing's syndrome due to a non-adrenal ectopic adrenocorticotropin-secreting Ewing's sarcoma in a child.
Ectopic ACTH syndrome (EAS) is extremely rare in the pediatric age group. Sarcomatous tumors causing EAS are even rarer. We report a 9 year-old girl presenting with Cushing's syndrome caused by ectopic ACTH production by a Ewing's sarcoma. This case illustrates that rapid appearance of Cushingoid symptoms, absence of growth retardation and the presence of hypokalemia are suggestive clues for ectopic ACTH production as the source of Cushing's syndrome.
Guran
Tulay
T
Pediatric Endocrinology and Diabetes, Marmara University, Istanbul, Turkey. tulayguran@yahoo.com
Turan
Serap
S
Ozkan
Behzat
B
Berrak
Su Gulsun
SG
Canpolat
Cengiz
C
Dagli
Tolga
T
Eren
Funda Sirin
FS
Bereket
Abdullah
A
D000182:ACTH Syndrome, Ectopic / Q000150:complications*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003480:Cushing Syndrome / Q000188:drug therapy / Q000209:etiology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012186:Retroperitoneal Neoplasms / Q000150:complications / Q000188:drug therapy; D012512:Sarcoma, Ewing / Q000150:complications* / Q000188:drug therapy; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D000324:Adrenocorticotropic Hormone