Actin-based protrusions: promoters or inhibitors of cancer invasion?
In a recent issue of Cell, Silva and colleagues reported the identification of CYFIP1, a member of the actin-assembly-promoting Scar/WAVE complex, as an invasion suppressor in epithelial cancers. This study challenges ideas about the role of actin in cancer invasion.
Machesky
Laura M
LM
The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, Scotland. l.machesky@beatson.gla.ac.uk
Tang
Hao Ran
HR
D000199:Actins / Q000378:metabolism*; D000818:Animals; D045744:Cell Line, Tumor; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D009154:Mutation; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D010477:Perfusion; D015398:Signal Transduction; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology; D014704:Veratrum Alkaloids / Q000627:therapeutic use
D000199:Actins; D053823:Hedgehog Proteins; C541444:IPI-926; D014704:Veratrum Alkaloids