Biaryl polyamides as a new class of DNA quadruplex-binding ligands.
We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.
Rahman
Khondaker M
KM
Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK WC1N 1AX.
Reszka
Anthony P
AP
Gunaratnam
Mekala
M
Haider
Shozeb M
SM
Howard
Philip W
PW
Fox
Keith R
KR
Neidle
Stephen
S
Thurston
David E
DE
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002942:Circular Dichroism; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D008024:Ligands; D009757:Nylons