title: Towards transgenic primates: What can we learn from mouse genetics?
abstract: Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.
authors: Brain and Behavior Discovery Institute, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA.
authors: Hui
authors: H
authors: KUANG
authors: Phillip L
authors: PL
authors: WANG
authors: Joe Z
authors: JZ
authors: TSIEN
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D055786:Gene Knockout Techniques; D006801:Humans; D051379:Mice / Q000235:genetics*; D011323:Primates / Q000235:genetics*; D019076:Transgenes