Pancreatic cancer--could it be that simple? A different context of vulnerability.
In a recent issue of Science, Olive and colleagues document that inhibition of Hedgehog (Hh) signaling in a genetically engineered mouse model of pancreatic cancer can enhance the intratumor concentration of certain anticancer drugs. Could this finding provide us with a new method to attack pancreatic cancer?
Von Hoff
Daniel D
DD
Translational Genomics Research Institute, Phoenix, AZ 85004, USA. dvh@tgen.org
Korn
Ron
R
Mousses
Spyro
S
D053823:Hedgehog Proteins / Q000502:physiology; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D010146:Pain; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000401:mortality / Q000473:pathology* / Q000503:physiopathology; D055420:Perfusion Imaging; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology
D053823:Hedgehog Proteins