title: Synthesis of novel bioactive derivatives of 3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidine-4(3H)-ones.
abstract: A series of triazolo[4,3-a]tetrahydrobenzo(b)thieno[3,2-e]pyrimidine-5(4H)-ones (12a-n) were synthesized and evaluated for CNS depressant, skeletal muscle relaxant and anticonvulsant activities by photoactometer, Rotarod and pentylenetetrazole induced the convulsions method respectively in Swiss albino mice. Diazepam was used as standard drug. The five derivatives 12b, 12c, 12d, 12i and 12m showed the CNS depressant and skeletal muscle relaxant activities comparable to those of diazepam at a dose of 5mg/kg. These derivatives also exhibited good activity when tested for anticonvulsant activity in mice at different dose levels. The ED(50) values for these derivatives are in the range of 4.40-9.33 mg/kg.
authors: Vinayakrao Patil Mahavidyalaya, Vaijapur Dist, Aurangabad 423 701, India.
authors: Sunil V
authors: SV
authors: Gupta
authors: Kamalkishor
authors: K
authors: Baheti
authors: Rajesh
authors: R
authors: Bora
authors: Deepak
authors: D
authors: Dekhane
authors: Mahesh
authors: M
authors: Chhabría
authors: Murlidhar
authors: M
authors: Shingare
authors: Shivaji
authors: S
authors: Pawar
authors: C J
authors: CJ
authors: Shishoo
authors: S N
authors: SN
authors: Thore
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry* / Q000627:therapeutic use*; D002492:Central Nervous System Depressants / Q000737:chemistry* / Q000627:therapeutic use*; D051379:Mice; D015394:Molecular Structure; D018482:Muscle, Skeletal / Q000187:drug effects; D011743:Pyrimidines / Q000737:chemistry* / Q000627:therapeutic use*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D011743:Pyrimidines