Interactions between angiotensin II and arginine vasopressin in water homeostasis.
Mice deficient in the angiotensin II type 1a (AT(1a)) receptor demonstrate a vasopressin-resistant nephrogenic diabetes insipidus. These knockout mice exhibit a threefold increase in 24-h urine excretion. Neither 2 weeks of exogenous vasopressin nor 5 days of fluid restriction reversed this polyuric state. This nephrogenic diabetes insipidus was associated with reductions in adenylyl cyclase protein and in the phosphorylated mitogen-activated protein kinase extracellular signal-regulated kinase 1/2. The results support an important interaction between vasopressin and angiotensin II in maximal urinary concentration.
Schrier
Robert W
RW
Department of Medicine, University of Colorado Denver, 12700 East 19th Avenue C281, Aurora, Colorado, USA.
D000262:Adenylyl Cyclases / Q000032:analysis; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D051399:Aquaporin 2 / Q000032:analysis; D001127:Arginine Vasopressin / Q000494:pharmacology*; D018500:Diabetes Insipidus, Nephrogenic / Q000209:etiology* / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D048052:Mitogen-Activated Protein Kinase 3 / Q000032:analysis / Q000378:metabolism; D010766:Phosphorylation; D011141:Polyuria; D044140:Receptor, Angiotensin, Type 1 / Q000172:deficiency*; D014556:Urine; D014882:Water-Electrolyte Balance / Q000502:physiology*
C496024:Aqp2 protein, mouse; D051399:Aquaporin 2; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II; D001127:Arginine Vasopressin; D048052:Mitogen-Activated Protein Kinase 3; D000262:Adenylyl Cyclases