Pulmonary adenocarcinoma with heterotopic ossification.
Pulmonary adenocarcinoma is a common malignancy that often involves calcification; however, bone formation in primary lung adenocarcinoma is extremely rare. In ten cases of primary pulmonary adenocarcinoma with heterotopic ossification, we detected immunoreactivity against TGF-beta1, osteopontin, osteocalcin and Runx2 in the fibroblastic stroma and tumor cells within the area of ossification. Our results suggest that in primary pulmonary adenocarcinoma, heterotopic ossification occurs via intramembranous bone formation. To our knowledge, only 11 other cases of pulmonary adenocarcinoma with heterotopic ossification have been reported. Here, we present ten cases of pulmonary adenocarcinoma showing heterotopic ossification with a description of previously published results and the histogenesis of heterotopic bone formation.
Kim
Gou Young
GY
Department of Pathology, East-West Neo Medical Center, College of Medicine, Kyung Hee University, Seoul, Korea.
Kim
Jhingook
J
Kim
Tae Sung
TS
Han
Joungho
J
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D050659:Core Binding Factor Alpha 1 Subunit / Q000378:metabolism; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000175:diagnosis* / Q000473:pathology; D015675:Osteocalcin / Q000378:metabolism; D053495:Osteopontin / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
D050659:Core Binding Factor Alpha 1 Subunit; C493709:RUNX2 protein, human; D053773:Transforming Growth Factor beta1; D015675:Osteocalcin; D053495:Osteopontin