title: [Common variable immunodeficiency: report of two cases and literature review].
abstract: OBJECTIVE
  To promote the awareness of common variable immunodeficiency (CVID).
  
  
  METHODS
  Report two cases of CVID and review related literature.
  
  
  RESULTS
  The two CVID patients were manifested recurrent infections of respiratory and digestive tract, splenomegaly, significantly reduced serum immunoglobulin, since adolescence. They were treated with intravenous gammaglobulin, anti-infection and symptomatic therapies and the diseases were well controlled. Case 1 was diagnosed as with spleen peripheral T cell lymphoma after splenectomy. Case 2 developed nutritional megaloblastic anemia resulting from repeated digestive tract infections.
  
  
  CONCLUSIONS
  CVID is a heterogeneous group of diseases with later-onset, characterized by hypogammaglobulinemia and recurrent bacterial infections. Early diagnosis and regular treatment may improve the prognosis.
authors: Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
authors: Jian-ping
authors: JP
authors: Li
authors: Hui-jun
authors: HJ
authors: Wang
authors: Lei
authors: L
authors: Zhang
authors: Ren-chi
authors: RC
authors: Yang
authors: Feng-kui
authors: FK
authors: Zhang
mesh_terms: D017074:Common Variable Immunodeficiency / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult