[Diffusion and diffusion-osmosis models of the charged macromolecule transfer in barriers of biosystems].
Mathematical models of the transfer of charged macromolecules have been constructed on the basis of the classical equations of electromigration diffusion of Helmholtz-Smolukhovskii, Goldman, and Goldman-Hodgkin-Katz. It was shown that ion transfer in placental (mimicking lipid-protein barriers) and muscle barriers occurs by different mechanisms. In placental barriers, the electromigration diffusion occurs along lipid-protein channels formed due to the conformational deformation of phospholipid and protein molecules with the coefficients of diffusion D = (2.6-3.6) x 10(-8) cm2/s. The transfer in muscle barriers is due to the migration across charged interfibrillar channels with the negative diffusion activation energy, which is explained by changes in the structure of muscle fibers and expenditures of thermal energy for the extrusion of Cl- from channel walls with the diffusion coefficient D = (6.0-10.0) x 10(-6) cm2/s.
Varakin
A I
AI
Mazur
V V
VV
Arkhipova
N V
NV
Serianov
Iu V
IuV
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002701:Chloramphenicol / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D004058:Diffusion; D004560:Electricity; D005260:Female; D006801:Humans; D017136:Ion Transport; D008055:Lipids / Q000502:physiology*; D055641:Mathematical Concepts; D008954:Models, Biological; D008968:Molecular Conformation; D018482:Muscle, Skeletal / Q000378:metabolism*; D009995:Osmosis; D010068:Oxacillin / Q000378:metabolism; D010400:Penicillin G / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011506:Proteins / Q000502:physiology*; D013816:Thermodynamics
D000900:Anti-Bacterial Agents; D002712:Chlorides; D008055:Lipids; D010743:Phospholipids; D011506:Proteins; D002701:Chloramphenicol; D010400:Penicillin G; D010068:Oxacillin