title: Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample.
abstract: Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P=0.01) and rs3918342 (P=0.02), and a highly significant under-transmission between haplotype CAT (P=0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.
authors: Department of Genetics and Molecular Biology, Xi'an Jiaotong University School of Medicine, 76 West Yan Ta Rd., Xi'an, Shaanxi, PR China.
authors: Jie
authors: J
authors: Ma
authors: Jian
authors: J
authors: Sun
authors: Huan
authors: H
authors: Zhang
authors: Rui
authors: R
authors: Zhang
authors: Wan-Hu
authors: WH
authors: Kang
authors: Cheng-Ge
authors: CG
authors: Gao
authors: Hai-Sheng
authors: HS
authors: Liu
authors: Xue-Hong
authors: XH
authors: Ma
authors: Zi-Xin
authors: ZX
authors: Min
authors: Wen-Xiang
authors: WX
authors: Zhao
authors: Qi-Lan
authors: QL
authors: Ning
authors: Shu-Hong
authors: SH
authors: Wang
authors: Yin-Cang
authors: YC
authors: Zhang
authors: Ting-Wei
authors: TW
authors: Guo
authors: She-Min
authors: SM
authors: Lu
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; C475071:DAOA protein, human; D047908:Intracellular Signaling Peptides and Proteins