Decreased ventral anterior cingulate cortex activity is associated with reduced social pain during emotional support.
People feel psychological pain when they are excluded, and this pain is often attenuated when emotional support is received. It is therefore likely that a specific neural mechanism underlies the detection of social exclusion. Similarly, specific neural mechanisms may underlie the beneficial effects of emotional support. Although neuroimaging researchers have recently examined the neural basis of social pain, there is presently no agreement as to which part of the anterior cingulate cortex (ACC) is involved in the perception and modulation of social pain. We hypothesized that activity in those brain regions that are associated with social pain would be correlated with decrements in social pain induced by emotional support. To examine the effects of emotional support on social pain caused by exclusion, we conducted an fMRI study in which participants played a virtual ball-tossing game. Participants were initially included and later excluded from the game. In the latter half of the session from which participants were excluded, participants received emotionally supportive text messages. We found that emotional support led to increased activity in the left lateral/medial prefrontal cortices and some temporal regions. Those individuals who experienced greater attenuation of social pain exhibited lower ventral ACC and higher left lateral prefrontal cortex activation. These results suggest that the ventral ACC underlies social pain, and that emotional support enhances prefrontal cortex activity, which in turn may lead to a weakened affective response.
Onoda
Keiichi
K
Hiroshima University, Hiroshima, Japan.
Okamoto
Yasumasa
Y
Nakashima
Ken'ichiro
K
Nittono
Hiroshi
H
Ura
Mitsuhiro
M
Yamawaki
Shigeto
S
D000328:Adult; D001931:Brain Mapping; D003657:Decision Making; D004644:Emotions / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007398:Interpersonal Relations; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010146:Pain / Q000473:pathology / Q000523:psychology*; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012649:Self Concept; D012934:Social Isolation; D012938:Social Perception; D055815:Young Adult
D010100:Oxygen