title: [Influence of three point mutations in TNF-alpha promoter gene in clinical manifestations and complications of stomach and duodenal ulcer].
abstract: The purpose of our study was to investigate whether polymorphisms -238G/A, -308G/A, and -863C/A within the promoter of the TNF-alpha gene are associated with clinical features of gastric and duodenal ulcer disease in a Russian population. DNA samples of 381 unrelated patients with gastric and duodenal ulcer disease and 216 sex- and age-matched healthy controls were used to determine the TNF-alpha gene polymorphisms by PCR-RFLP assay. Logistic regression analysis has revealed significant associations of polymorphism -308G/A with size of ulcerous defect (p=0.03) and intestinal dyspepsia (p=0.05), polymorphism -238G/A with gastric dyspepsia (p=0.04) and reflux-esophagitis (p=0.05), polymorphism -863C/A with perforation of ulcer (p=0.04). The study results highlight impact of the TNF-alpha gene polymorphisms on various clinical features in patients with peptic ulcer disease.
authors: A V
authors: AV
authors: Polonikov
authors: V P
authors: VP
authors: Ivanov
authors: M A
authors: MA
authors: Solodilova
authors: A I
authors: AI
authors: Shveĭnov
authors: O S
authors: OS
authors: Manuĭlova
authors: M A
authors: MA
authors: Kozhukhov
authors: M P
authors: MP
authors: Tutochkina
authors: A A
authors: AA
authors: Stepchenko
authors: I V
authors: IV
authors: Bulgakova
mesh_terms: D016022:Case-Control Studies; D004381:Duodenal Ulcer / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D006801:Humans; D016015:Logistic Models; D015999:Multivariate Analysis; D017354:Point Mutation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha