title: An EMA negative, desmin positive malignant mesothelioma: limitations of immunohistochemistry?
abstract: Histopathologists in the current environment of medical negligence and litigation are more likely to use immunohistochemical investigations in their day-to-day practice to support their diagnosis and avoid future litigation. The caveat is that relying on immunohistochemistry is a double-edged sword and pathologists should be familiar with its limitations. We present a case of primary malignant peritoneal mesothelioma with an unusual immunohistochemical profile-desmin positive, EMA negative-and wish to highlight the importance of cautiously interpreting immunohistochemistry profiles when they do not fit the clinical history and histological appearance.
authors: East Lancashire Hospitals, UK. walidsalman@gmail.com
authors: W D
authors: WD
authors: Salman
authors: B
authors: B
authors: Eyden
authors: D
authors: D
authors: Shelton
authors: A
authors: A
authors: Howat
authors: A
authors: A
authors: Al-Dawoud
authors: Z
authors: Z
authors: Twaij
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D003893:Desmin / Q000378:metabolism*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D010534:Peritoneal Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D003893:Desmin; D018396:Mucin-1