title: Independent elaboration of steroid hormone signaling pathways in metazoans.
abstract: Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics.
authors: Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1 and Centre National de Recherche Scientifique, Institut National de Recherche Agronomique, Ecole Normale Supérieure de Lyon, Lyon Cedex 07, France.
authors: Gabriel V
authors: GV
authors: Markov
authors: Raquel
authors: R
authors: Tavares
authors: Chantal
authors: C
authors: Dauphin-Villemant
authors: Barbara A
authors: BA
authors: Demeneix
authors: Michael E
authors: ME
authors: Baker
authors: Vincent
authors: V
authors: Laudet
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D019143:Evolution, Molecular; D020440:Gene Duplication; D006728:Hormones / Q000378:metabolism*; D008024:Ligands; D016013:Likelihood Functions; D008957:Models, Genetic; D010088:Oxidoreductases / Q000235:genetics; D010802:Phylogeny; D015398:Signal Transduction; D013045:Species Specificity; D013256:Steroids / Q000378:metabolism*; D014714:Vertebrates / Q000235:genetics
chemical_list: D006728:Hormones; D008024:Ligands; D013256:Steroids; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases