title: Synthesis and biological evaluation of 2,5-diaminobenzamide derivatives as anti-proliferating agents.
abstract: The screening of the chemical library for the anti-proliferative activity of the chemical library provided 2,5-diaminobenzamide as the initial hit. The confirmation and the optimization of hit were performed by synthesis followed by the evaluation of growth inhibitory activity against human cancer cell lines. The most active growth inhibitor showed IC(50) of 1.0 microM. The compound 7 increased not only sub-G1 population but also number of cells which are stained with Annexin V-FITC and 7-AAD, suggesting that compound 7 induced cell death is apoptosis.
authors: Department of Chemistry, Keimyung University, Daegu 704-701, Korea.
authors: Sang-Hyo
authors: SH
authors: Lee
authors: Jong-Won
authors: JW
authors: Park
authors: Ji-Eun
authors: JE
authors: Hong
authors: Jong-Wook
authors: JW
authors: Park
authors: Jinho
authors: J
authors: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D017209:Apoptosis; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D054852:Small Molecule Libraries / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D054852:Small Molecule Libraries