Rotavirus and the indigenous children of the Australian outback: monovalent vaccine effective in a high-burden setting.
Indigenous children living in arid Central Australia experience frequent outbreaks of rotavirus gastroenteritis. A widespread outbreak of G9 rotavirus infection occurred several months after introduction of the RIX4414 rotavirus vaccine. We performed a retrospective case-control study to determine vaccine efficacy during the outbreak. Two doses provided an estimated vaccine efficacy of 77.7% (95% confidence interval, 40.2%-91.7%) against hospitalization for gastroenteritis. Vaccine efficacy was 84.5% (95% confidence interval, 23.4%-96.9%) against confirmed cases of rotavirus infection. Vaccination was effective in this high-burden setting.
Snelling
Thomas L
TL
Menzies School of Health Research and Charles Darwin University, Darwin, Australia. thomas.snelling@menzies.edu.au
Schultz
Rosalie
R
Graham
Julie
J
Roseby
Robert
R
Barnes
Graeme L
GL
Andrews
Ross M
RM
Carapetis
Jonathan R
JR
D001315:Australia / Q000453:epidemiology; D016022:Case-Control Studies; D002675:Child, Preschool; D004196:Disease Outbreaks; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007223:Infant; D044382:Population Groups; D012189:Retrospective Studies; D012401:Rotavirus / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000276:immunology*
D022243:Rotavirus Vaccines