title: Psychosocial stress and liver disease status.
abstract: "Psychosocial stress" is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported by patients during the course of disease, usually accompanied by a decline in their overall health status. As the mechanisms involving glucocorticoids and catecholamines have been deciphered, and their actions on immune cell function deeper understood, it has become clear that stress has an impact on hepatic inflammatory response. An increasing number of articles have approached the link between psychosocial stress and the negative evolution of hepatic diseases. This article reviews a number of studies on both human populations and animal models performed in recent years, all linking stress, mainly of psychosocial nature, and the evolution of three important liver-related pathological entities: viral hepatitis, cirrhosis and hepatocellular carcinoma.
authors: Department of Internal Medicine, Emergency County Hospital of Craiova, Craiova, Dolj, Romania
authors: Cristin Constantin
authors: CC
authors: Vere
authors: Costin Teodor
authors: CT
authors: Streba
authors: Letitia Maria
authors: LM
authors: Streba
authors: Alin Gabriel
authors: AG
authors: Ionescu
authors: Felix
authors: F
authors: Sima
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D006521:Hepatitis, Chronic / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D008107:Liver Diseases / Q000276:immunology / Q000503:physiopathology / Q000523:psychology*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D010913:Pituitary-Adrenal System / Q000502:physiology; D011379:Prognosis; D013315:Stress, Psychological / Q000503:physiopathology / Q000523:psychology*; D013564:Sympathetic Nervous System / Q000502:physiology / Q000503:physiopathology