title: Influence of anti-HBc seropositivity on the risk of hepatocellular carcinoma in HCV-infected patients after adjusting for confounding factors.
abstract: It is controversial whether past hepatitis B virus infection constitutes an additional risk of hepatocellular carcinoma (HCC) among patients with hepatitis C virus (HCV). The incidence of HCC between 1994 and 2004 was analysed among 1262 patients who were only positive for HCV. The cumulative incidence of HCC was assessed by Kaplan-Meier analysis and the difference between two groups was assessed by the log-rank test. The effect of anti-HBc positivity on the risk of HCC was assessed with multivariate Cox proportional analysis. Anti-HBc was positive in 522 (41.4%) patients. The proportion of male patients (56.7 vs 46.8%, P < 0.001) and mean age (60.8 vs 56.9 years, P < 0.001) were significantly higher in the anti-HBc positive group. HCC developed in 339 patients (mean follow-up 7.0 years), with cumulative incidence rates at 3, 5 and 10 years of 12.7, 24.5 and 41.9% in the anti-HBc positive group and 10.6, 17.7 and 33.4% in the negative group, respectively (P = 0.005). However, anti-HBc seropositivity did not reach statistical significance in multivariate analysis including age and gender (hazard ratio, 1.06; 95% CI, 0.85-1.31; P = 0.63). Anti-HBc positivity and HCC incidence were confounded by male gender and older age.
authors: Department of Gastroenterology, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors: T
authors: T
authors: Ohki
authors: R
authors: R
authors: Tateishi
authors: E
authors: E
authors: Goto
authors: T
authors: T
authors: Sato
authors: R
authors: R
authors: Masuzaki
authors: J
authors: J
authors: Imamura
authors: T
authors: T
authors: Goto
authors: F
authors: F
authors: Kanai
authors: N
authors: N
authors: Kato
authors: S
authors: S
authors: Shiina
authors: H
authors: H
authors: Yoshida
authors: T
authors: T
authors: Kawabe
authors: M
authors: M
authors: Omata
mesh_terms: D000367:Age Factors; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology*; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D006510:Hepatitis B Antibodies