title: The IGF-I response to growth hormone is related to body mass index in short children with normal weight.
abstract: OBJECTIVE
  We investigated whether the insulin-like growth factor (IGF)-I response to growth hormone (GH) is regulated by body mass index (BMI) in short children with normal weight.
  
  
  METHODS
  We studied 37 prepubertal children with idiopathic short stature (ISS), comparing children with high-normal BMI (standard deviation scores, SDS 1.23 +/- 0.11, n = 20) and low-normal BMI (SDS -0.93 +/- 0.12, n = 17). The IGF-I response to GH was determined with an abbreviated IGF-I generation test, by measuring serum IGF-I concentrations at baseline and 24 h after the administration of GH (0.033 mg/kg).
  
  
  RESULTS
  Children with high- and low-normal BMI had similar age (8.5 +/- 0.7 vs. 8.7 +/- 0.7 years) and height (-2.0 +/- 0.1 vs. -2.2 +/- 0.2 SDS). However, children with high-normal BMI exhibited higher mean basal IGF-I (191 +/- 15 vs. 139 +/- 11 ng/ml, p < 0.05), higher mean IGF-I levels 24 h after GH administration (261 +/- 22 vs. 164 +/- 14 ng/ml, p < 0.05) and a higher IGF-I percent increase after GH administration (37 +/- 5 vs. 17 +/- 4%, p < 0.05) compared with children with normal-low BMI.
  
  
  CONCLUSIONS
  BMI modulates the IGF-I response to GH, suggesting that GH sensitivity may be influenced by the nutritional status in children with ISS and normal body weight.
authors: Institute of Maternal and Child Research, University of Chile, San Borja Arriarán Hospital, Santiago, Chile.
authors: Rossana
authors: R
authors: Roman
authors: German
authors: G
authors: Iniguez
authors: Juan Javier
authors: JJ
authors: Lammoglia
authors: Alejandra
authors: A
authors: Avila
authors: Teresa
authors: T
authors: Salazar
authors: Fernando
authors: F
authors: Cassorla
mesh_terms: D001823:Body Composition; D015992:Body Mass Index; D002648:Child; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I