Control of KIT signalling in male germ cells: what can we learn from other systems?
The KIT ligand (KITL)/KIT-signalling system is among several pathways known to be essential for fertility. In the postnatal testis, the KIT/KITL interaction is crucial for spermatogonial proliferation, differentiation, survival and subsequent entry into meiosis. Hence, identification of endogenous factors that regulate KIT synthesis is important for understanding the triggers driving germ cell maturation. Although limited information is available regarding local factors in the testicular microenvironment that modulate KIT synthesis at the onset of spermatogenesis, knowledge from other systems could be used as a basis for identifying how KIT function is regulated in germ cells. This review describes the known regulators of KIT, including transcription factors implicated in KIT promoter regulation. In addition, specific downstream outcomes in biological processes that KIT orchestrates are addressed. These are discussed in relationship to current knowledge of mammalian germ cell development.
Mithraprabhu
Sridurga
S
Monash Institute for Medical Research, Monash University, Clayton, Victoria, Australia.
Loveland
Kate L
KL
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism; D006801:Humans; D008297:Male; D008322:Mammals / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D008954:Models, Biological; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D013091:Spermatogenesis / Q000235:genetics / Q000502:physiology; D013094:Spermatozoa / Q000378:metabolism*; D019089:Stem Cell Factor / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit