Diurnal physiology: core principles with application to the pathogenesis, diagnosis, prevention, and treatment of myocardial hypertrophy and failure.
The circadian system has been shown to be fundamentally important in human health and disease. Recently, there have been major advances in our understanding of daily rhythmicity, and its relevance to human physiology, and to the pathogenesis and treatment of cardiac hypertrophy and heart failure. Cardiovascular tissues, such as heart and blood vessels, show remarkable daily variation in gene expression, metabolism, growth, and remodeling. Moreover, synchrony of daily molecular and physiological rhythms is integral to healthy organ growth and renewal. Disruption of these rhythms adversely affects normal growth, also the remodeling mechanisms in disease, leading to gross abnormalities in heart and vessels. These observations provide new insights into the pathogenesis, diagnosis, treatment, and prevention of heart disease. In this review, we focus on the recent advances in circadian biology and cardiovascular function, with particular emphasis on how this applies to human myocardial hypertrophy and heart failure, and the implications and importance for translational medicine.
Sole
Michael J
MJ
Toronto General Hospital Research Institute, University Health Network, Heart and Stroke, Richard Lewar Centre of Excellence, University of Toronto, Toronto, Canada. michael.sole@uhn.on.ca
Martino
Tami A
TA
D000818:Animals; D001683:Biological Clocks / Q000235:genetics; D006332:Cardiomegaly / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D002317:Cardiovascular Agents / Q000008:administration & dosage; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D021081:Chronobiology Disorders / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000235:genetics; D055870:Drug Chronotherapy; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D012890:Sleep; D016896:Treatment Outcome
D002317:Cardiovascular Agents