[Juvenile dermatomyositis associated with anasarca - a clinical case].
Juvenile dermatomyositis (JDM) is a rare systemic disease of unknown etiology characterized by inflammation of the muscle, skin and digestive tract, with variable outcome. The diagnostic criteria include proximal symmetrical muscular weakness, characteristic skin rashes, elevation of skeletal muscle enzymes and specific electromyographic and muscle biopsy abnormalities. Pulmonary and gastro-intestinal involvements, calcinosis and generalized edema usually indicate severe disease. Recent data suggest an association between the genotype -308 AA of the Tumour Necrosis Factor (TNF) gene and disease chronicity. We present a case of a 14 year-old female with JDM and generalized oedema which is a rare manifestation of the disease and it is associated to a poor outcome.
Mourão
Ana Filipa
AF
Serviço de Reumatologia, Centro Hospitalar de Lisboa Ocidental, EPE, Hospital Egas Moniz, 1349-019 Lisboa. filipamourao@yahoo.com
Pinto
Teresa Laura
TL
Falcão
Sandra
S
Ribeiro
Célia
C
Vieira
Helena
H
Caetano-Lopes
Joana
J
Nero
Patrícia
P
dos Santos
Fernando Pimental
FP
Guimarães
José
J
Branco
Jaime Cunha
JC
D000293:Adolescent; D003882:Dermatomyositis / Q000150:complications*; D004487:Edema / Q000150:complications*; D005260:Female; D006801:Humans; D012871:Skin Diseases / Q000150:complications*