Application of genetically modified and cloned pigs in translational research.
Pigs are increasingly being recognized as good large-animal models for translational research, linking basic science to clinical applications in order to establish novel therapeutics. This article reviews the current status and future prospects of genetically modified and cloned pigs in translational studies. It also highlights pigs specially designed as disease models, for xenotransplantation or to carry cell marker genes. Finally, use of porcine somatic stem and progenitor cells in preclinical studies of cell transplantation therapy is also discussed.
Matsunari
Hitomi
H
Laboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki 214-8571, Japan.
Nagashima
Hiroshi
H
D000818:Animals; D030801:Animals, Genetically Modified; D035843:Biomedical Research / Q000379:methods*; D019976:Cloning, Organism / Q000379:methods / Q000706:statistics & numerical data; D004195:Disease Models, Animal; D017930:Genes, Reporter / Q000502:physiology; D008954:Models, Biological; D033581:Stem Cell Transplantation / Q000379:methods; D013552:Swine / Q000235:genetics*; D014183:Transplantation, Heterologous / Q000379:methods