title: The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.
abstract: An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC proto-oncogene. These data provide strong support for a biological mechanism underlying this non-protein-coding risk variant.
authors: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
authors: Mark M
authors: MM
authors: Pomerantz
authors: Nasim
authors: N
authors: Ahmadiyeh
authors: Li
authors: L
authors: Jia
authors: Paula
authors: P
authors: Herman
authors: Michael P
authors: MP
authors: Verzi
authors: Harshavardhan
authors: H
authors: Doddapaneni
authors: Christine A
authors: CA
authors: Beckwith
authors: Jennifer A
authors: JA
authors: Chan
authors: Adam
authors: A
authors: Hills
authors: Matt
authors: M
authors: Davis
authors: Keluo
authors: K
authors: Yao
authors: Sarah M
authors: SM
authors: Kehoe
authors: Heinz-Josef
authors: HJ
authors: Lenz
authors: Christopher A
authors: CA
authors: Haiman
authors: Chunli
authors: C
authors: Yan
authors: Brian E
authors: BE
authors: Henderson
authors: Baruch
authors: B
authors: Frenkel
authors: Jordi
authors: J
authors: Barretina
authors: Adam
authors: A
authors: Bass
authors: Josep
authors: J
authors: Tabernero
authors: José
authors: J
authors: Baselga
authors: Meredith M
authors: MM
authors: Regan
authors: J Robert
authors: JR
authors: Manak
authors: Ramesh
authors: R
authors: Shivdasani
authors: Gerhard A
authors: GA
authors: Coetzee
authors: Matthew L
authors: ML
authors: Freedman
mesh_terms: D000483:Alleles; D045744:Cell Line, Tumor; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D004742:Enhancer Elements, Genetic / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011485:Protein Binding; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D051820:TCF Transcription Factors / Q000378:metabolism; D058118:Transcription Factor 7-Like 2 Protein
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc; D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein