title: Renal transplant from very old donors: how far can we go?
abstract: BACKGROUND
  The organ shortage has led many transplant centers to accept kidneys from old, suboptimal deceased donors, and make increasing use of old-for-old allocation systems. We report the experience of an Italian transplant center in the utilization of "ultra-old" (>75 years old) donors.
  
  
  METHODS
  Sixty grafts from donors aged 75 years or older (mean age 79.1 years, range 75-90 years) were used for 38 patients: 16 as single and 22 as double transplants.
  
  
  RESULTS
  The actuarial graft survival rate was 73.7% for year 1, 69.8% for year 2, and 64.0% for year 3. The patient survival rate was 81.2% and remained stable for years 1, 2, and 3. The delayed graft function rate was 57.9%. Acute rejection and chronic allograft nephropathy rates were comparable with our other expanded criteria donors. The majority of the patients had stable creatinine levels, between 2 and 3 mg/mL after the second month, with sufficient creatinine clearance.
  
  
  CONCLUSIONS
  Our results seems encouraging with patient and graft survival rates, complication rates, and renal function parameters being slightly worse than in expanded criteria donors, but still generally acceptable. The use of old kidneys in old recipients, bearing in mind their usual life expectancy, gives them a properly functioning kidney and improved quality of life.
authors: UOC Chirurgia dei Trapianti, Azienda Ospedaliera Universitaria Senese, V.le Bracci, Siena, Italy. collini@unisi.it
authors: Andrea
authors: A
authors: Collini
authors: Peter
authors: P
authors: Kalmar
authors: Armando
authors: A
authors: Dhamo
authors: Giuliana
authors: G
authors: Ruggieri
authors: Mario
authors: M
authors: Carmellini
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007558:Italy; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality / Q000502:physiology*; D008017:Life Expectancy; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis; D017741:Survivors / Q000706:statistics & numerical data; D014019:Tissue Donors / Q000706:statistics & numerical data*
chemical_list: D007166:Immunosuppressive Agents