Influence of a new self-gripping hernia mesh on male fertility in a rat model.
BACKGROUND
The number of mesh-based therapies of inguinal hernias is increasing compared with the classical suture techniques such as Shouldice and Bassini. Many different types of meshes with regard to material, pore size and surface coating are available. A recently offered mesh (Parietene Progrip) combines the properties of a standard lightweight polypropylene mesh with a whole surface fixation by incorporation of micro hooks. Therefore, additional fixation elements such as screws, tacks or clips become redundant when using this material. However, in treated male patients the micro hooks will also come into contact with the ductus deferens. As the sensitivity of this structure is known, the question arises of whether this new self-gripping mesh might damage susceptible tissue layers and impair male fertility.


METHODS
Two different meshes, a standard lightweight polypropylene mesh (Parietene-Light) and a new self-gripping polypropylene mesh (Parietene Progrip) with absorbable micro hooks were wrapped surgically around the prepared ductus deferens of each of ten Sprague-Dawley rats. In five control rats ducts were only separated bluntly from adherent tissue. After 2 months rats were sacrificed and implants were recovered together with the ductus deferens for histology and electron microscopy.


RESULTS
Samples from all animals showed an unrestricted lumen of the ductus deferens. Only minor inflammatory reactions with some infiltrating cells could be observed. Giant cells were present around the mesh fibres. Scanning electron microscopy revealed no degradation of the material surface after 2 months of implantation.


CONCLUSIONS
The new self-gripping mesh showed no harmful influence on the ductus deferens in the rat model. Considering the larger dimensions of the ductus deferens in humans any detrimental effect on the exposed tissue can be excluded. The surface of the fibres was not subjected to material degradation.
Kolbe
Thomas
T
Biomodels Austria, University of Veterinary Medicine, Vienna, Austria. Thomas.Kolbe@vu-wien.ac.at
Hollinsky
Christian
C
Walter
Ingrid
I
Joachim
Anja
A
Rülicke
Thomas
T
D000818:Animals; D004867:Equipment Design; D015726:Giant Cells / Q000473:pathology; D006552:Hernia, Inguinal / Q000601:surgery; D007248:Infertility, Male / Q000209:etiology*; D007249:Inflammation; D019344:Lactic Acid; D010535:Laparoscopy; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011108:Polymers; D011126:Polypropylenes; D051381:Rats; D017207:Rats, Sprague-Dawley; D013526:Surgical Mesh / Q000009:adverse effects*; D014649:Vas Deferens / Q000293:injuries* / Q000473:pathology
D011091:Polyesters; D011108:Polymers; D011126:Polypropylenes; D019344:Lactic Acid; C033616:poly(lactide)