title: Delivery of gastroschisis patients before 37 weeks of gestation is associated with increased morbidities.
abstract: BACKGROUND
  Despite advances in the care of neonates with gastroschisis, patients present with significant morbidities. Preterm delivery of neonates with gastroschisis is often advocated to avoid the intestinal damage that may be sustained with prolonged exposure to amniotic fluid. However, preterm delivery may impose additional morbidities to this disease process.
  
  
  METHODS
  We conducted a retrospective review of patients with gastroschisis born from 1989 to 2007. Demographic and clinical data were collected. Preterm healthy neonates, with gestational age from 26 to 36 weeks, were used as controls.
  
  
  RESULTS
  Preterm infants with gastroschisis had a 14 times higher risk for any of the recorded morbidities. As compared to term neonates with gastroschisis, preterm neonates with gastroschisis had a higher rate of sepsis, longer duration to reach full enteral feedings, and longer length of stay. Although the preterm infants with gastroschisis were less likely to be small for gestational age at birth, they were as likely as the term infants with gastroschisis to have failure to thrive at discharge and had a greater drop in weight percentile during hospitalization.
  
  
  CONCLUSIONS
  Preterm delivery should be avoided because there is no clear benefit to the gut in avoiding derivative injuries. Meticulous attention should be given to the nutritional needs of patients with gastroschisis.
authors: Department of Pediatrics, Division of Neonatology, Brenner Children's Hospital at Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157, USA. hmaramreddy@yahoo.com
authors: Hima
authors: H
authors: Maramreddy
authors: Joie
authors: J
authors: Fisher
authors: Michael
authors: M
authors: Slim
authors: Edmund F
authors: EF
authors: Lagamma
authors: Boriana
authors: B
authors: Parvez
mesh_terms: D001724:Birth Weight; D036861:Delivery, Obstetric / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D020139:Gastroschisis / Q000453:epidemiology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D009017:Morbidity / Q000639:trends; D009518:New York / Q000453:epidemiology; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors