Aluminum, calcium ion and radiofrequency synergism in acceleration of lymphomagenesis.
This study that was done on lymphomagene-bearing mice indicates a synergism aluminum-radiofrequency which induces an early increase in mortality that is in concomitance with lymphoid elements proliferation and infiltration of spleen and liver. These two last phenomena were assessed by determination of the hypertrophic index (Growth Index) which is the organ weight to to the body weight ratio, as well as by the histopathological examination of the organ tissue. The importance of this synergism appears to be determined by the ionization at the physiological pH of the used aluminum complexes: much higher with lactate complex than with the citrate one. On the other hand, this dissociation appears to induce a remarkable acceleration of the mortality and the lymphoid elements-related hypertrophy of the spleen and liver at early age. Aluminum complexes are known as modifiers of the intracellular calcium homeostasis, and to verify if such process could be implicated in this synergism, the effects of calcium chloride were assayed, in this case the calcium-overload had no effects in the presence of a workable cellular control of intracellular calcium homeostasis. This finding support the hypothesis that ionized aluminum provided by lactate may be implicated in the inhibition of the buffering and extruding extracellular calcium system.
Anghileri
Leopoldo José
LJ
Biophysics Laboratory, Faculty of Medicine, University of Nancy, France. leopoldo.anghileri@wanadoo.fr
Mayayo
Emilio
E
Domingo
José Luis
JL
D000535:Aluminum / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D002118:Calcium / Q000009:adverse effects* / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000528:radiation effects*; D005260:Female; D006706:Homeostasis / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000276:immunology / Q000473:pathology; D008223:Lymphoma / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D051379:Mice; D011846:Radio Waves / Q000009:adverse effects*; D013154:Spleen / Q000276:immunology / Q000473:pathology
D000535:Aluminum; D002118:Calcium