Characterization of antiplatelet properties of silver nanoparticles.
Thrombotic disorders have emerged as serious threat to society. As anticoagulant and thrombolytic therapies are usually associated with serious bleeding complications, the focus has now shifted to regulating and maintaining platelets in an inactive state. In the present study we show that nanosilver has an innate antiplatelet property and effectively prevents integrin-mediated platelet responses, both in vivo and in vitro, in a concentration-dependent manner. Ultrastructural studies show that nanosilver accumulates within platelet granules and reduces interplatelet proximity. Our findings further suggest that these nanoparticles do not confer any lytic effect on platelets and thus hold potential to be promoted as antiplatelet/antithrombotic agents after careful evaluation of toxic effects.
Shrivastava
Siddhartha
S
Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Bera
Tanmay
T
Singh
Sunil K
SK
Singh
Gajendra
G
Ramachandrarao
P
P
Dash
Debabrata
D
D053768:Metal Nanoparticles / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D012834:Silver / Q000737:chemistry*
D010975:Platelet Aggregation Inhibitors; D012834:Silver