Can eccentric arterial plaques alone cause flow stagnation points and favour thrombus incorporation?
We have used an experimental model of aorta stenosis, with a Plexiglas plug, simulating a stable atheromatous plaque that promotes local turbulence and thrombosis. With animal survival of more than 24 h, we followed the partial fibrinolysis of the thrombus as well as its posterior organization and incorporation to the arterial wall as a neointima for up to 30 days. The mushroom plug form permitted the development of recirculation and stasis areas around it, favouring this evolution. Despite noted limitations, this study demonstrates that thrombus incorporation can contribute to plaque extension, as it can promote recirculation and stasis areas.
Beneli
Cristina T
CT
Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Barbosa
Priscila F
PF
Floriano
Elaine M
EM
Abreu
Mônica A
MA
Ramalho
Fernando S
FS
Júnior
Jorge Elias
JE
Rossi
Marcos A
MA
Ramos
Simone G
SG
D000818:Animals; D001011:Aorta / Q000648:ultrastructure; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D018056:Hemorheology; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017208:Rats, Wistar; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D018615:Ultrasonography, Doppler, Color / Q000379:methods