title: Low catalase activity in blood is associated with the diabetes caused by alloxan.
abstract: BACKGROUND
  Hydrogen peroxide is enzymatically processed by catalase, and catalase deficiency in blood is known as acatalasemia. We examined whether low catalase activity is a risk factor for diabetes mellitus.
  
  
  METHODS
  Blood glucose, insulin and glucose tolerance test were examined in acatalasemic and normal mice under non-stress and oxidative stress conditions. Alloxan administration was used as oxidative stress.
  
  
  RESULTS
  Alloxan, which was a drug that caused diabetes mellitus, mostly generated hydrogen peroxide by the reaction of alloxan and reduced glutathione, in vitro. Incidence of hyperglycemia in alloxan-untreated acatalasemic mice was as low as that in the normal mice. However, the incidence of acatalasemia mice treated with alloxan was higher than that in normal mice, and the number of pancreatic beta-cells in the acatalasemic mice was less than that in normal mice.
  
  
  CONCLUSIONS
  These results indicate that low catalase activity in the blood is associated with the diabetes mellitus caused by alloxan administration.
authors: Kake Medical Science Education Center, Okayama, Japan.
authors: Kazunori
authors: K
authors: Takemoto
authors: Miho
authors: M
authors: Tanaka
authors: Hiroshi
authors: H
authors: Iwata
authors: Ryou
authors: R
authors: Nishihara
authors: Kohji
authors: K
authors: Ishihara
authors: Da-Hong
authors: DH
authors: Wang
authors: Keiki
authors: K
authors: Ogino
authors: Koji
authors: K
authors: Taniuchi
authors: Noriyoshi
authors: N
authors: Masuoka
mesh_terms: D020642:Acatalasia / Q000097:blood / Q000150:complications* / Q000201:enzymology* / Q000473:pathology; D000496:Alloxan / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002374:Catalase / Q000097:blood* / Q000378:metabolism; D048909:Diabetes Complications / Q000097:blood / Q000201:enzymology / Q000473:pathology; D003920:Diabetes Mellitus / Q000097:blood / Q000139:chemically induced* / Q000201:enzymology* / Q000473:pathology; D005951:Glucose Tolerance Test; D005978:Glutathione / Q000378:metabolism; D006461:Hemolysis; D006861:Hydrogen Peroxide / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008853:Microscopy; D018384:Oxidative Stress / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan; D006861:Hydrogen Peroxide; D002374:Catalase; D005978:Glutathione