title: Lack of association between the MDM2 promoter polymorphism SNP309 and clinical outcome in chronic lymphocytic leukemia.
abstract: The 309T>G polymorphism in the promoter region of the MDM2 gene, known as SNP309, has recently been suggested as an unfavorable prognostic marker in chronic lymphocytic leukemia (CLL) although this has been questioned. To investigate this further, we analyzed the MDM2 SNP309 genotypes in 418 CLL patients and correlated the results with established CLL prognostic factors, time to treatment and overall survival. In this Swedish cohort, no association existed between any particular MDM2 SNP309 genotype, overall survival and time to treatment. Furthermore, no correlation was shown between the MDM2 SNP309 genotypes and Binet stage, IGHV mutational status and recurrent genomic aberrations. In summary, this study argues against the use of the MDM2 SNP309 as a prognostic marker in CLL.
authors: Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.
authors: Mohd Arifin
authors: MA
authors: Kaderi
authors: Mahmoud
authors: M
authors: Mansouri
authors: Norafiza
authors: N
authors: Zainuddin
authors: Nicola
authors: N
authors: Cahill
authors: Rebeqa
authors: R
authors: Gunnarsson
authors: Mattias
authors: M
authors: Jansson
authors: Eva
authors: E
authors: Kimby
authors: Anna
authors: A
authors: Aleskog
authors: Jeanette
authors: J
authors: Lundin
authors: Bengt
authors: B
authors: Glimelius
authors: Mads
authors: M
authors: Melbye
authors: Gunnar
authors: G
authors: Juliusson
authors: Jesper
authors: J
authors: Jurlander
authors: Richard
authors: R
authors: Rosenquist
mesh_terms: D004252:DNA Mutational Analysis; D050438:Genes, Immunoglobulin Heavy Chain; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000401:mortality*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*
chemical_list: D051736:Proto-Oncogene Proteins c-mdm2