title: The juxtamembrane region of EGFR takes center stage.
abstract: The activation process for the epidermal growth factor receptor (EGFR) involves formation of an asymmetric dimer of the tyrosine kinase domains. Jura et al. (2009) in this issue and Brewer et al. (2009) in Molecular Cell now demonstrate that the juxtamembrane region of EGFR plays a crucial role in stabilizing this dimer.
authors: Structural Biology Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. stevan.hubbard@med.nyu.edu
authors: Stevan R
authors: SR
authors: Hubbard
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D019281:Dimerization; D066246:ErbB Receptors / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data
chemical_list: D066246:ErbB Receptors