Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits.
The digallic acid obtained from the fruit Pistacia lentiscus exhibits an inhibitory activity against nitrofurantoine and B[a]P induced genotoxicity when tested by the SOS chromotest bacterial assay system in the presence of Escherichia coli PQ37 strain. The antioxidant activity of the tested compound was determined by its ability to scavenge the free radical ABTS(+), to inhibit the xanthine oxidase, involved in the generation of free radicals, and to inhibit the lipid peroxidation induced by H(2)O(2) in the K562 cell line. Our results revealed that digallic acid shows an important free radical scavenging activity towards the ABTS(+) radical (99%) and protection against lipid peroxidation (68%).
Bhouri
Wissem
W
Unité de Pharmacognosie/BiologieMoléculaire 99/UR/07 03, Faculté de Pharmacie/Médecine Dentaire de Monastir, Rue Avicenne, 5000 Monastir, Tunisia.
Derbel
Safa
S
Skandrani
Ines
I
Boubaker
Jihed
J
Bouhlel
Ines
I
Sghaier
Mohamed B
MB
Kilani
Soumaya
S
Mariotte
Anne M
AM
Dijoux-Franca
Marie G
MG
Ghedira
Kamel
K
Chekir-Ghedira
Leila
L
D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles; D049109:Cell Proliferation / Q000187:drug effects; D053630:Depsides / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D016166:Free Radical Scavengers; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D020014:K562 Cells; D015227:Lipid Peroxidation; D015394:Molecular Structure; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D027927:Pistacia / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry; D013481:Superoxides; D013844:Thiazoles / Q000737:chemistry; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D016587:Antimutagenic Agents; D000975:Antioxidants; D052160:Benzothiazoles; D053630:Depsides; D016166:Free Radical Scavengers; D009153:Mutagens; D013451:Sulfonic Acids; D013844:Thiazoles; D013481:Superoxides; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C067648:digallic acid; D005707:Gallic Acid; D014969:Xanthine Oxidase