title: Guided tissue regeneration-based root coverage with a platelet concentrate graft: a 3-year follow-up case series.
abstract: BACKGROUND
  A platelet concentrate graft (PCG) was applied underneath the barrier membrane in guided tissue regeneration (GTR)-based root coverage procedures. The purpose of this case study was to assess the effectiveness of the technique and the long-term outcomes.
  
  
  METHODS
  Thirty-seven Miller Class I or II recession defects in six patients were treated using the PCG and a collagen membrane covered by an advanced mucogingival flap. Clinical parameters, such as vertical gingival recession depth (VRD), clinical attachment level (CAL), probing depth (PD), and width of keratinized tissue (WKT), were recorded presurgery (at baseline [BL]) and at 6 and 36 months of follow-up. The Wilcoxon signed-rank test and the Mann-Whitney test were used to assess statistical significance (alpha = 0.05).
  
  
  RESULTS
  Between BL and 6 months, there was a statistically significant reduction in VRD (from 2.81 +/- 0.88 mm to 0.30 +/- 0.48 mm) and PD (from 2.59 +/- 0.50 mm to 1.14 +/- 0.35 mm), as well as an improvement in CAL (from 5.41 +/- 0.86 mm to 1.43 +/- 0.66 mm). These results remained stable over the following 30 months. There was no statistically significant change in WKT during the initial 6 months; however, the increase in WKT was statistically significant at the 36-month follow-up. When comparing the healing between the maxillary and mandibular teeth at 6 months, the VRD reduction was statistically significantly greater in the maxillary teeth, but the difference was not statistically significant 30 months later. The average root coverage at 6 and 36 months was 89.86% +/- 15.85% and 85.86% +/- 18.16%, respectively, with complete root coverage in 24 (64.86%) and 21 (56.76%) of the 37 teeth.
  
  
  CONCLUSIONS
  The GTR-based technique using PCG was effective in reducing gingival recession. The outcomes remained stable for 3 years.
authors: Department of Periodontology, Tufts University School of Dental Medicine, Boston, MA, USA. terrence.griffin@tufts.edu
authors: Terrence J
authors: TJ
authors: Griffin
authors: Wai S
authors: WS
authors: Cheung
mesh_terms: D020341:Absorbable Implants; D001684:Biological Dressings; D001792:Blood Platelets; D005500:Follow-Up Studies; D005881:Gingiva / Q000601:surgery; D005889:Gingival Recession / Q000601:surgery*; D005893:Gingivoplasty / Q000379:methods*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008567:Membranes, Artificial; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: D008567:Membranes, Artificial