title: Eosinophilic esophagitis in a dog.
abstract: METHODS
  A 4-year-old spayed female mixed-breed dog with a history of allergic skin disease was examined because of regurgitation, coughing, and dysphagia that began 15 days after abdominal surgery for correction of gastric dilatation and volvulus.
  
  
  RESULTS
  Severe diffuse esophagitis, esophageal dysmotility, and a benign esophageal stricture at the level of the base of the heart were identified via contrast videofluoroscopy and esophagoscopy. Severe diffuse eosinophilic ulcerative esophagitis was confirmed by histologic examination of esophageal biopsy specimens and cytologic evaluation of specimens obtained by use of a cytology brush. Esophageal eosinophils were evident (14% to 50% of the inflammatory cell population and > 25 eosinophils/hpf).
  
  
  RESULTS
  No clinical or endoscopic improvement was evident after treatment with antireflux medications, including a proton-pump inhibitor, following an initial esophageal bougienage procedure. An excellent response characterized by resolution of dysphagia and regurgitation with marked improvement of the esophageal mucosa was evident following intralesional and systemic administration of glucocorticoids, 2 additional esophageal bougienage procedures, and feeding of an elimination diet.
  
  
  CONCLUSIONS
  To our knowledge, the information reported here is the first description of eosinophilic esophagitis (EE) in a dog. Many similarities exist between the condition in the dog reported here and EE in humans. This clinical report highlights the need to consider EE as a differential diagnosis for esophagitis and esophageal strictures in dogs. When appropriate, esophageal biopsy or cytologic specimens should be obtained and examined to investigate the possibility of EE.
authors: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
authors: Michael J
authors: MJ
authors: Mazzei
authors: Sally A
authors: SA
authors: Bissett
authors: K Marcia
authors: KM
authors: Murphy
authors: Stuart
authors: S
authors: Hunter
authors: Jennifer A
authors: JA
authors: Neel
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004802:Eosinophilia / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D004941:Esophagitis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; D011241:Prednisone