title: Retrospective correction for T1-weighting bias in T2 values obtained with various spectroscopic spin-echo acquisition schemes.
abstract: Localized tissue transverse relaxation time (T(2)) is obtained by fitting a decaying exponential to the signals from several spin-echo experiments at different echo times (TE). Unfortunately, time constraints in magnetic resonance spectroscopy (MRS) often mandate in vivo acquisition schemes at short repetition times (TR), that is, comparable with the longitudinal relaxation constant (T(1)). This leads to different T(1)-weighting of the signals at each TE. Unaccounted for, this varying weighting causes systematic underestimation of the T(2)'s, sometimes by as mush as 30%. In this article, we (i) analyze the phenomenon for common MRS spin-echo T(2) acquisition schemes; (ii) propose a general post hoc T(1)-bias correction for any (TR, TE) combination; (iii) show that approximate knowledge of T(1) is sufficient, since a 20% uncertainty in T(1) leads to under 3% bias in T(2); and consequently, (iv) efficient, precision-optimized short TR spin-echo T(2) measurement protocols can be designed and used without risk of accuracy loss. Tables of correction for single-refocusing (conventional) spin-echo and double refocusing, such as, PRESS acquisitions, are provided.
authors: Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
authors: Roman
authors: R
authors: Fleysher
authors: Lazar
authors: L
authors: Fleysher
authors: Ivan
authors: I
authors: Kirov
authors: David A
authors: DA
authors: Hess
authors: Songtao
authors: S
authors: Liu
authors: Oded
authors: O
authors: Gonen
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology; D003198:Computer Simulation; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012815:Signal Processing, Computer-Assisted; D012984:Software; D013997:Time Factors