Purinergic regulation of vascular tone and remodelling.
1 Purinergic signalling is involved both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling. 2 There is dual control of vascular tone by adenosine 5'-triphosphate (ATP) released from perivascular nerves and by ATP released from endothelial cells in response to changes in blood flow (shear stress) and hypoxia. 3 Both ATP and its breakdown product, adenosine, regulate smooth muscle and endothelial cell proliferation. 4 These regulatory mechanisms are important in pathological conditions, including hypertension, atherosclerosis, restenosis, diabetes and vascular pain.
Burnstock
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Autonomic Neuroscience Centre, Royal Free and University College Medical School, London NW3 2PF, United Kingdom.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D009129:Muscle Tonus / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000254:growth & development* / Q000502:physiology*; D032389:Myocytes, Smooth Muscle / Q000502:physiology; D011983:Receptors, Purinergic / Q000502:physiology*
D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate