Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population.
Several investigations have suggested that disruption of circadian rhythms may provide the foundation for the development of mood disorders such as bipolar disorder (BP) and major depressive disorder (MDD). Recent animal studies reported that prokineticin 2 or prokineticin 2 receptor gene deficient mice showed disruptions in circadian and homeostatic regulation of sleep. This evidence indicates that prokineticin 2 gene (PROK2) and prokineticin 2 receptor gene (PROKR2) are good candidate genes for the pathogenesis of mood disorders. To evaluate the association between PROK2, PROKR2, and mood disorders, we conducted a case-control study of Japanese samples (151 bipolar patients, 319 major depressive disorder patients, and 340 controls) with four and five tagging SNPs in PROK2 or PROKR2, respectively, selected by HapMap database. We detected a significant association between PROKR2 and major depressive disorder and bipolar disorder in the Japanese population. In conclusion, our findings suggest that PROKR2 may play a role in the pathophysiology of mood disorders in the Japanese population. However, because our samples were small, it will be important to replicate and confirm these findings in other independent studies using larger samples.
Kishi
Taro
T
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470-1192, Japan. tarok@fujita-hu.ac.jp
Kitajima
Tsuyoshi
T
Tsunoka
Tomoko
T
Okumura
Takenori
T
Ikeda
Masashi
M
Okochi
Tomo
T
Kinoshita
Yoko
Y
Kawashima
Kunihiro
K
Yamanouchi
Yoshio
Y
Ozaki
Norio
N
Iwata
Nakao
N
D000328:Adult; D000818:Animals; D044466:Asian People / Q000235:genetics*; D005091:Exons; D005260:Female; D005768:Gastrointestinal Hormones / Q000235:genetics / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D018000:Receptors, Peptide / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
D005768:Gastrointestinal Hormones; D009479:Neuropeptides; C423608:PROK2 protein, human; C470838:PROKR2 protein, human; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide