title: First trimester PTX3 levels in women who subsequently develop preeclampsia and fetal growth restriction.
abstract: Pentraxin 3 (PTX3) and C-reactive protein (CRP) levels were measured in the first trimester of pregnancy in women who subsequently developed preeclampsia (PE, n=16) and fetal growth restriction (FGR, n=12) requiring iatrogenic delivery before 37 weeks, and those who had uncomplicated pregnancies delivering at term (n=60). Mean PTX3 levels were significantly higher in women who subsequently developed PE (7.31 ng/ml, SD = 4.12) when compared to those with normal pregnancy outcome (4.92 ng/ml, SD = 1.94, p=0.0046). There were no significant differences between PTX3 levels in women with FGR (4.82 ng/ml, SD = 2.35) compared to normal pregnancy outcome (p=0.88). The median CRP levels did not vary significantly between the three groups (p=0.26). PTX3 levels in women who subsequently develop PE are already elevated in the first trimester, but not in those that develop FGR. This supports the hypothesis of an excessive maternal inflammatory response to pregnancy in the etiology of PE.
authors: Unit of Obstetrics and Gynecology I, Department of Clinical Sciences Luigi Sacco, University of Milan, Italy.
authors: Irene
authors: I
authors: Cetin
authors: Veronica
authors: V
authors: Cozzi
authors: Aris T
authors: AT
authors: Papageorghiou
authors: Virginia
authors: V
authors: Maina
authors: Alessandro
authors: A
authors: Montanelli
authors: Cecilia
authors: C
authors: Garlanda
authors: Basky
authors: B
authors: Thilaganathan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D006801:Humans; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D012307:Risk Factors; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D018709:Statistics, Nonparametric; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins