Association of obestatin with blood pressure in the third trimesters of pregnancy.
Obestatin is a recently discovered 23-amino acid peptide encoded by the same gene that encodes ghrelin. It has been reported that there is a significant negative correlation between the plasma ghrelin concentration and systemic blood pressure in patients with pregnancy-induced hypertension. We investigated the plasma concentration of obestatin in 18 non-pregnant women, 18 normal pregnant women, and 15 patients with pregnancy-induced hypertension. The plasma concentrations of obestatin in these 3 groups of women were 63.4+/-9.5pg/ml, 38.1+/-6.3pg/ml, and 46.0+/-9.3pg/ml, respectively. In non-pregnant women, there was no correlation between the plasma obestatin concentration and the mean arterial pressure. However, there was a positive correlation between the plasma obestatin concentration and the mean arterial pressure in normal pregnant women and pregnant women with pregnancy-induced hypertension. These results suggest that obestatin may have some potential role in the regulation of blood pressure in normal pregnant women and women with pregnancy-induced hypertension.
Ren
An-jing
AJ
Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai, China.
He
Qian
Q
Shi
Jing-Song
JS
Guo
Zhi-Fu
ZF
Zheng
Xing
X
Lin
Li
L
Wang
Yang-Kai
YK
Xia
Song-Yun
SY
Sun
Li-Li
LL
Du
Xin
X
Sun
Ying
Y
Zhang
Lan-Mei
LM
Yuan
Wen-Jun
WJ
D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D054439:Ghrelin; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood; D036361:Peptide Hormones / Q000097:blood*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood* / Q000502:physiology*; D055815:Young Adult
D054439:Ghrelin; D036361:Peptide Hormones; C505799:obestatin, human