Spatial distribution of deep sulcal landmarks and hemispherical asymmetry on the cortical surface.
The locally deepest regions of major sulci, the sulcal pits, are thought to be the first cortical folds to develop and are closely related to functional areas. We examined the spatial distribution of sulcal pits across the entire cortical region, and assessed the hemispheric asymmetry in their frequency and distribution in a large group of normal adult brains. We automatically extracted sulcal pits from magnetic resonance imaging data using surface-based methods and constructed a group map from 148 subjects. The spatial distribution of the sulcal pits was relatively invariant between individuals, showing high frequency and density in specific focal areas. The left and right sulcal pits were spatially covariant in the regions of the earliest developed sulci. The sulcal pits with great spatial invariance appear to be useful as stable anatomical landmarks. We showed the most significant asymmetry in the frequency and spatial variance of sulcal pits in the superior temporal sulcus, which might be related to the lateralization of language function to the left hemisphere, developing more consistently and strongly than for the right. Our analyses support previous empirical and theoretical studies, and provide additional insights concerning the anatomical and functional development of the brain.
Im
Kiho
K
Department of Biomedical Engineering, Hanyang University, Seoul 133-791, South Korea.
Jo
Hang Joon
HJ
Mangin
Jean-François
JF
Evans
Alan C
AC
Kim
Sun I
SI
Lee
Jong-Min
JM
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D016009:Chi-Square Distribution; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008959:Models, Neurological; D055815:Young Adult