title: Retrospective analysis of histopathologic prognostic factors after hepatectomy for intrahepatic cholangiocarcinoma.
abstract: BACKGROUND
  The aim of this study was to investigate histopathologic prognostic factors in patients with intrahepatic cholangiocarcinoma (ICC) whose tumors were resected to determine the optimal surgical strategies.
  
  
  METHODS
  One hundred and two ICC patients who underwent laparotomy from July 1998 to December 2000 were followed up successfully. Histopathologic variables were selected for univariate and multivariate analyses to evaluate their influence on the outcome.
  
  
  RESULTS
  The 1-, 3-, and 5-year survival rates after surgery were 56.9%, 25.5%, and 16.9%, respectively. The average survival duration was 21.91 +/- 20.17 months. In univariate analysis, the presence of lymph node (LN) metastasis, number of LNs with metastases, presence of intrahepatic metastasis, curative resection, and TNM stage were significant risk factors for survival. Multivariate analysis revealed that intrahepatic metastasis, noncurative resection, and TNM stage IVa were independent prognostic factors.
  
  
  CONCLUSIONS
  The histopathologic characteristics of intrahepatic metastasis were closely related to poor prognosis in ICC patients. Extensive hepatectomy with LN dissection may offer the only chance for long-term survival in patients with ICC.
authors: Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, People's Republic of China. jiang_beige@yahoo.com.cn
authors: Bei-Ge
authors: BG
authors: Jiang
authors: Liang-Liang
authors: LL
authors: Sun
authors: Wen-Long
authors: WL
authors: Yu
authors: Zhao-Hui
authors: ZH
authors: Tang
authors: Ming
authors: M
authors: Zong
authors: Yong-Jie
authors: YJ
authors: Zhang
mesh_terms: D001650:Bile Duct Neoplasms / Q000401:mortality / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000601:surgery*; D018281:Cholangiocarcinoma / Q000401:mortality / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007813:Laparotomy; D008113:Liver Neoplasms / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate