[A case-control study on the association of RFC-1 polymorphism and cervical cancer].
OBJECTIVE
To evaluate the possible association between RFC-1 polymorphism and cervix carcinoma, as well as the interaction between polymorphism and human papilloma virus16 (HPV16).


METHODS
Based on a hospital-based case-control study, 107 cases which were diagnosed as cervical cancer pathematologically and 107 controls with hysteromyoma, were selected by frequency, matched with age and habitation. HPV16 and RFC-1 A80G polymorphism were detected by special PCR and RFLP.


RESULTS
(1) HPV16 infection rate in cases (56.07%) was higher than that in controls (31.78%) with the adjusted OR of 3.25 (95% CI: 1.74-6.08). (2) All the genotypes were tested by Hardy-Weinberg balance. (3) Compared with RFC-1 AA,RFC-1 GG had higher risk for cervical cancer with OR of 2.42 (95% CI: 1.01-5.81). (4) No statistical significance was noticed regarding the interaction between RFC-1 polymorphism and HPV16 in logistic regression method.


CONCLUSIONS
The introduction of RFC-1 80GG gene type could increase the risk of cervical cancer.
Di
Juan-juan
JJ
Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China.
Wang
Jin-tao
JT
Ding
Ling
L
Wang
Zhi-min
ZM
Gao
Er-sheng
ES
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D052162:Human papillomavirus 16; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D051818:Replication Protein C / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
D004279:DNA, Viral; C081632:RFC1 protein, human; D051818:Replication Protein C