title: Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former New Zealand trichlorophenol workers.
abstract: This study examined serum levels of 2,3,7,8-substituted chlorinated dioxins and furans, and 15 PCBs for 346 New Zealand employees who worked at a site that manufactured 2,4,5-trichlorophenol (TCP) and 2,4,5-trichlorophenoxy acetic acid (2,4,5-T). Participants with potential TCP or 2,4,5-T exposures had mean lipid-adjusted 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) levels of 9.9 ng kg(-1) lipid compared to 4.9 ng kg(-1) for workers with no exposure at the site. Among exposed workers, we found evidence of differences in 2,3,7,8-TCDD levels by department and duties. Workers involved in an accidental release had the highest mean 2,3,7,8-TCDD levels, 37.9 ng kg(-1), followed by workers in the trichlorophenol plant, 23.4 ng kg(-1). Workers with potential intermittent exposures to 2,3,7,8-TCDD in construction, maintenance, mechanics, and transport had 2,3,7,8-TCDD levels above New Zealand background levels of 3.9 ng kg(-1), indicating workplace exposures. Among participants with work history indicating no 2,3,7,8-TCDD exposures, we observed some individuals with 2,3,7,8-TCDD levels above background levels. However, in most cases, these workers reported workplace exposures not recorded on their work histories or held other jobs with the potential for 2,3,7,8-TCDD exposures outside the plant. All other dioxin, furan, and PCB levels were similar among the exposed and unexposed workers.
authors: The Dow Chemical Company, Midland, MI, USA. jjcollins@dow.com
authors: James J
authors: JJ
authors: Collins
authors: Michael
authors: M
authors: Wilken
authors: David
authors: D
authors: McBride
authors: Noel F
authors: NF
authors: Humphry
authors: Peter
authors: P
authors: Herbison
authors: Carol J
authors: CJ
authors: Burns
authors: Kenneth
authors: K
authors: Bodner
mesh_terms: D015085:2,4,5-Trichlorophenoxyacetic Acid; D001572:Benzofurans / Q000097:blood*; D002617:Chemical Industry; D002733:Chlorophenols; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants / Q000097:blood*; D006801:Humans; D009520:New Zealand; D016273:Occupational Exposure / Q000032:analysis*; D011078:Polychlorinated Biphenyls / Q000097:blood; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D001572:Benzofurans; D002733:Chlorophenols; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; C009534:2,4,5-trichlorophenol; D015085:2,4,5-Trichlorophenoxyacetic Acid; D011078:Polychlorinated Biphenyls