title: Early predictors of microvascular complications in type 1 diabetic patients.
abstract: OBJECTIVE
  To investigate the possibility of depending on adiponectin and leptin as early predictors of microvascular complications in type 1 diabetic subjects.
  
  
  METHODS
  We studied 63 type 1 diabetic subjects from the National Institute of Diabetes (30 normoalbuminuric and 33 microalbuminuric). Clinical, demographic characteristics and kidney function tests were monitored. Plasma levels of adiponectin, leptin, interlukein-6 (IL-6), and the high sensitive C-reactive protein (CRP) were measured in these subjects.
  
  
  RESULTS
  Microalbuminuric subjects showed a significant elevation in adiponectin levels and a significant decrease in leptin levels as compared to normoalbuminuric subjects. Adiponectin showed a significant positive correlation with microalbuminuria concentrations while leptin showed a significant negative correlation with both fasting blood glucose and glycated hemoglobin A(1c).
  
  
  CONCLUSIONS
  The results of this study introduced the possibility of depending on adiponectin and leptin as early, reliable, and sensitive predictors for the microvascular complications monitored by microalbuminuria concentration and glycemic control indices.
authors: Clinical Nutrition Department, National Nutrition Institute, Cairo, Egypt.
authors: Awatif M
authors: AM
authors: Abd El-Maksoud
authors: Mohammed H
authors: MH
authors: El Hefnawy
authors: Shaymaa M M
authors: SM
authors: Yahya
authors: Dina M
authors: DM
authors: Seoudi
authors: Abdel-Rahman B
authors: AR
authors: Abdel-Ghaffar
authors: Emad F
authors: EF
authors: Eskander
authors: Hanaa H
authors: HH
authors: Ahmed
authors: Ibrahim H
authors: IH
authors: Kamal
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000419:Albuminuria / Q000097:blood / Q000150:complications / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D042241:Early Diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005215:Fasting / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007677:Kidney Function Tests; D020738:Leptin / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D012044:Regression Analysis; D014652:Vascular Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D015850:Interleukin-6; D020738:Leptin