title: Non-transferrin-bound iron in haematological patients during chemotherapy and conditioning for autologous stem cell transplantation.
abstract: Free iron induced hydroxyl radical formation is one possible mechanism for tissue injury during cytotoxic therapy. We studied the appearance of free, non-transferrin-bound iron (NTBI) at baseline and during the 20-d period after the onset of cytotoxic chemotherapy in patients with haematological malignancy undergoing intensive chemotherapy or conditioning for autologous stem cell transplantation (aSCT). NTBI was detected on average for 15.6 d in patients treated with chemotherapy only, and for 6.1 d in patients undergoing aSCT. The recovery of the bone marrow function coincided with the disappearance of NTBI. The type of the conditioning regimen was also associated with the appearance of NTBI. The timing of the presence of NTBI accords with the presence of the most important non-infectious complication of intensive chemotherapy and autologous transplantation, mucosal injury, and free iron is likely to contribute to this and probably other complications of the intensive treatments.
authors: Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
authors: Leila
authors: L
authors: Sahlstedt
authors: Leni
authors: L
authors: von Bonsdorff
authors: Freja
authors: F
authors: Ebeling
authors: Jaakko
authors: J
authors: Parkkinen
authors: Eeva
authors: E
authors: Juvonen
authors: Tapani
authors: T
authors: Ruutu
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001853:Bone Marrow / Q000378:metabolism; D005260:Female; D019337:Hematologic Neoplasms / Q000097:blood* / Q000628:therapy*; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D033581:Stem Cell Transplantation; D013997:Time Factors; D014168:Transferrin; D014182:Transplantation, Autologous
chemical_list: D014168:Transferrin; D007501:Iron