title: Oxygenase catalyzed 5-methylcytosine hydroxylation.
abstract: Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA (Kriaucionis and Heintz, 2009; Tahiliani et al., 2009). This discovery has potential far-reaching implications for epigenetic regulation and will stimulate efforts to identify new nucleic acid modifications.
authors: Chemistry Research Laboratory and The Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
authors: Christoph
authors: C
authors: Loenarz
authors: Christopher J
authors: CJ
authors: Schofield
mesh_terms: D044503:5-Methylcytosine / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis; D020134:Catalytic Domain; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D006900:Hydroxylation; D006899:Mixed Function Oxygenases; D010105:Oxygenases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D044503:5-Methylcytosine; D006899:Mixed Function Oxygenases; C462539:TET1 protein, human; D010105:Oxygenases