title: Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican Americans.
abstract: OBJECTIVE
  Genetic polymorphisms in the paraoxonase 2 (PON2) gene are thought to alter its activity and contribute to the development of cardiovascular and renal disease risk. The purpose of this study is to determine whether the Arg148Gly, Cys311Ser and rs12794795 polymorphisms of PON2 examined previously by others, are associated with type 2 diabetes (T2DM), and subclinical measures of cardiovascular and renal disease risk in Mexican Americans.
  
  
  METHODS
  Study participants (n = 848; 21 families) were genotyped for the three polymorphisms by TaqMan assay. Association between the genotypic and phenotypic data was performed by measured genotype approach as implemented in the variance component analytical tools.
  
  
  RESULTS
  The Arg148Gly variant was found to be monomorphic in our dataset. Of the phenotypes examined for association, the A/C variant located in intron-1 (rs12794795) exhibited statistically significant association only with diastolic blood pressure (p = 0.018) after accounting for the trait-specific covariate effects. The Cys311Ser variant failed to show statistically significant association with any of the phenotypes examined.
  
  
  CONCLUSIONS
  In conclusion, the variants examined at the PON2 locus in Mexican Americans do not appear to be a major contributor to T2DM, cardiovascular or renal disease risk, although they exhibited a small effect on the blood pressure values.
authors: Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex., USA. thameem@uthscsa.edu
authors: Farook
authors: F
authors: Thameem
authors: Xin
authors: X
authors: He
authors: V Saroja
authors: VS
authors: Voruganti
authors: Subrata D
authors: SD
authors: Nath
authors: Paolo
authors: P
authors: Fanti
authors: John
authors: J
authors: Blangero
authors: Jean W
authors: JW
authors: Maccluer
authors: Anthony G
authors: AG
authors: Comuzzie
authors: Nedal H
authors: NH
authors: Arar
authors: Hanna E
authors: HE
authors: Abboud
mesh_terms: D043303:Aryldialkylphosphatase / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005192:Family Health; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007674:Kidney Diseases / Q000208:ethnology / Q000235:genetics*; D017058:Mexican Americans / Q000235:genetics; D017720:Molecular Epidemiology; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D043303:Aryldialkylphosphatase; C468411:PON2 protein, human