title: Sensorineural hearing loss in patients with cystic fibrosis.
abstract: OBJECTIVE
  To determine the prevalence of sensorineural hearing loss (SNHL) in cystic fibrosis (CF) patients and its relationship to antibiotic use.
  
  
  METHODS
  Case series with chart review.
  
  
  METHODS
  Tertiary care pediatric hospital.
  
  
  METHODS
  We reviewed the medical records of CF patients seen in our children's hospital between March 1994 and December 2007. Data collected included patient demographics, audiograms, tympanograms, genotype, and use of potentially ototoxic antibiotics.
  
  
  RESULTS
  Seven of 50 (14%) patients had SNHL. Three percent of patients who received <or=10 courses of intravenous aminoglycosides had SNHL versus 43 percent of those who received >10 courses (P<0.01). No patients who received five or fewer courses of nasal irrigation with aminoglycosides had SNHL versus 23 percent of those who received more than five courses (P<0.05). Nine percent of patients who received five or fewer courses of macrolides had SNHL versus 60 percent of those who received more than five courses (P=0.079).
  
  
  CONCLUSIONS
  CF patients receiving aminoglycosides are at high risk for developing SNHL.
authors: Department of Otolaryngology and Communication Enhancement, Children's Hospital Boston, and Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA. aglcheng@stanford.edu
authors: Alan G
authors: AG
authors: Cheng
authors: Patrick R
authors: PR
authors: Johnston
authors: Jennifer
authors: J
authors: Luz
authors: Ahmet
authors: A
authors: Uluer
authors: Brian
authors: B
authors: Fligor
authors: Greg R
authors: GR
authors: Licameli
authors: Margaret A
authors: MA
authors: Kenna
authors: Dwight T
authors: DT
authors: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D000617:Aminoglycosides / Q000008:administration & dosage / Q000009:adverse effects*; D001299:Audiometry; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D016013:Likelihood Functions; D016015:Logistic Models; D008297:Male
chemical_list: D000617:Aminoglycosides