Cytotoxic and antimycobacterial prenylated flavonoids from the roots of Eriosema chinense.
Eight new prenylated flavonoids, khonklonginols A-H (1-8), together with six known compounds including five flavonoids, lupinifolinol (9), dehydrolupinifolinol (10), flemichin D (11), eriosemaone A (12), and lupinifolin (13), and one lignan, yangambin (14), have been isolated from hexane and dichloromethane extracts of the roots of Eriosema chinense. The structures of 1-8 were elucidated by spectroscopic methods. The compounds were evaluated for cytotoxic activity against the small-cell lung (NCI-H187) and oral epidermal carcinoma (KB) human cell lines as well as for antimycobacterial activity against Mycobacterium tuberculosis H37Ra.
Sutthivaiyakit
Somyote
S
Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand. s_somyote@ru.ac.th
Thongnak
Oracha
O
Lhinhatrakool
Thitima
T
Yodchun
Orapan
O
Srimark
Ratree
R
Dowtaisong
Prisana
P
Chuankamnerdkarn
Mayuree
M
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D018517:Plant Roots / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D000995:Antitubercular Agents; D005419:Flavonoids