Tumors line up for a letdown.
MicroRNAs (miRNAs) and the pathways that regulate their expression have critical functions during normal development. A new study demonstrates that select cancer cells have appropriated one developmental mechanism of miRNA regulation, the inhibition of let-7 biogenesis by the Lin-28 and Lin-28B RNA binding proteins, to rid themselves of an antitumorigenic miRNA.
Mendell
Joshua T
JT
McKusick-Nathans Institute of Genetic Medicine and Department of Pediatrics and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jmendell@jhmi.edu
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics
D004268:DNA-Binding Proteins; C516326:LIN28B protein, human; C000715187:Lin28A protein, human; D035683:MicroRNAs; D016601:RNA-Binding Proteins; C487931:mirnlet7 microRNA, human