Crystal forms of atorvastatin.
The objective of this work was to investigate the existence of new polymorphs and pseudopolymorphs of atorvastatin and the transformation of crystal forms. Three crystal forms of atorvastatin have been isolated by recrystallization and characterized by powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TG). The PXRD and DSC patterns of the three crystal forms were different respectively and it was confirmed that Form 3 is a new crystal form. After storage of 2 years at room temperature, this new crystal form was not transformed and it was shown to have a good physical stability.
An
Su-Gyeong
SG
College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea.
Sohn
Young-Taek
YT
D000069059:Atorvastatin; D002152:Calorimetry, Differential Scanning; D003460:Crystallization / Q000379:methods*; D004355:Drug Stability; D006538:Heptanoic Acids / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin