Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation.
Reducing the electron density of ligands switches the regioselectivity of Rh(I)-catalyzed hydrometalation. A reversal of the sense of chiral induction was also observed when chiral ligands are electronically tuned in the same manner. The combined data provide an alternative rationale for the electronic effects often observed in asymmetric hydrogenation.
Wu
Hai-Chen
HC
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Hamid
Shafida Abd
SA
Yu
Jin-Quan
JQ
Spencer
Jonathan B
JB
D002384:Catalysis; D004583:Electrons; D006865:Hydrogenation; D008956:Models, Chemical; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D012238:Rhodium