[Clinic value of combination of high-risk human papillomavirus test and cervical cytology test in diagnosing cervical lesions].
OBJECTIVE
To investigate the clinic value of combination of high-risk human papillomavirus test and cervical cytology test in diagnosis of cervical lesions.


METHODS
Patients underwent physical examination at our department were checked by high-risk human papillomavirus test, cervical cytology test and colposcope from October 2004 to December 2006. Abnormal patients with cervical abnormalities were asked for pathological test.The diagnostic value of cervical lesions among these different methods were compared.


RESULTS
Based on the criteria of histopathology, the sensitivity, specificity, positive-predictive value and negative-predictive value of high-risk human papillomavirus test for detecting all cases of CIN II and CIN III were 94.83%, 31.06%, 55.22% and 87.02% respectively, and those of the cervical cytology were 92.10%, 31.06%, 54.50% and 81.43% respectively.Those values changed to 99.65%, 18.55%, 61.46% and 97.62% respectively if two methods were combined.


CONCLUSIONS
Human papillomavirus test and cervical cytology test combined with pathological test can improve the detective rate of cervical lesions and facilitate the treatment.
Zhou
Jin-nian
JN
Department of Obstetrics and Gynecology, Peking University First Hospital, Beiing 100034, China.
Zhao
Jian
J
Yang
Ying-jie
YJ
Liao
Qin-ping
QP
D000293:Adolescent; D000328:Adult; D000368:Aged; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis*; D011247:Pregnancy; D011933:Reagent Kits, Diagnostic; D002577:Uterine Cervical Diseases / Q000175:diagnosis*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000821:virology
D011933:Reagent Kits, Diagnostic