Enantioselective Reduction of Prochiral Ketones using Spiroborate Esters as Catalysts.
Novel spiroborate esters derived nonracemic 1,2-aminoalcohols and ethylene glycol are reported as highly effective catalysts for the asymmetric borane reduction of a variety of prochiral ketones with borane-dimethyl sulfide complex at room temperature. Optically active alcohols were obtained in excellent chemical yields using 0.1 to 10 mol % of catalysts with up to 99% ee.
Stepanenko
Viatcheslav
V
Department of Chemistry, University of Puerto Rico - Humacao, CUH Station, Humacao, Puerto Rico 00791, USA.
De Jesus
Melvin
M
Correa
Wildeliz
W
Guzman
Irisbel
I
Vazquez
Cindybeth
C
de la Cruz
Wilanet
W
Ortiz-Marciales
Margarita
M
Barnes
Charles L
CL