New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis.
Eichner
Simone
S
Zentrum für Biomolekulare Wirkstoffe (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany.
Floss
Heinz G
HG
Sasse
Florenz
F
Kirschning
Andreas
A
D062365:Aminobenzoates / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry* / Q000494:pharmacology; D055162:Biocatalysis; D045744:Cell Line, Tumor; D006801:Humans; D062385:Hydroxybenzoates; D047029:Lactams, Macrocyclic / Q000737:chemistry* / Q000494:pharmacology; D009154:Mutation; D048630:Polyketide Synthases / Q000378:metabolism; D013302:Streptomyces / Q000201:enzymology / Q000235:genetics
D062365:Aminobenzoates; D000970:Antineoplastic Agents; D016227:Benzoquinones; D062385:Hydroxybenzoates; D047029:Lactams, Macrocyclic; C031509:3-amino-5-hydroxybenzoic acid; D048630:Polyketide Synthases; C001277:geldanamycin