title: [Primary prevention trials performed with statins prior to the JUPITER trial].
abstract: The invention of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, namely statins, after the mid-1980s, initiated a new era in the approach to atherosclerotic diseases. Many studies of primary prevention, secondary prevention, and plaque regression have been carried out with statins. This paper will discuss primary prevention studies that were performed with statins prior to the JUPITER trial.
authors: Karadeniz Teknik Universitesi Tip Fakültesi Kardiyoloji Anabilim Dali, Trabzon, Turkey. merihbaykan@yahoo.com
authors: Merih
authors: M
authors: Baykan
mesh_terms: D050197:Atherosclerosis / Q000150:complications / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D011322:Primary Prevention / Q000379:methods* / Q000592:standards
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors