Association between antibody response against cytomegalovirus strain-specific glycoprotein H epitopes and HLA-DR.
The gH of CMV is a major target for strain-specific neutralizing antibodies. To verify whether there is a correlation between HLA-DR type and strain-specific antibodies, antibodies against CMV gH in potential donors and recipients for renal transplantation were investigated. Among 471 subjects, 404 (86%) showed reactivity to CMV gH, but no antibodies against gH were detected in 67 (14%) subjects. The positive rates were over 80% in most HLA subpopulations. Fewer subjects with HLA-DR10 and DR11 had antibodies to CMV gH than did those without HLA-DR10 and DR11. HLA-DR10 and DR11 may be associated with fewer/non-responders for strain-specific neutralizing antibodies.
Ishibashi
Kei
K
Department of Urology, Fukushima Medical University, Fukushima, Japan. keikun@fmu.ac.jp
Tokumoto
Tadahiko
T
Shirakawa
Hiroki
H
Hashimoto
Koichi
K
Kushida
Nobuhiro
N
Yanagida
Tomohiko
T
Shishido
Keiichi
K
Aikawa
Ken
K
Yamaguchi
Osamu
O
Toma
Hiroshi
H
Tanabe
Kazunari
K
Suzutani
Tatsuo
T
D000914:Antibodies, Viral / Q000097:blood*; D000917:Antibody Formation; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000821:virology; D000939:Epitopes / Q000276:immunology*; D006684:HLA-DR Antigens / Q000145:classification* / Q000276:immunology; D059810:HLA-DR Serological Subtypes; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D009500:Neutralization Tests; D014019:Tissue Donors; D014759:Viral Envelope Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C421823:HLA-DR10 antigen; C080766:HLA-DR11 antigen; D014759:Viral Envelope Proteins; C071440:glycoprotein H, Cytomegalovirus