Glutathione exhibits antibacterial activity and increases tetracycline efficacy against Pseudomonas aeruginosa.
Glutathione (GSH) plays important roles in pulmonary diseases, and inhaled GSH therapy has been used to treat cystic fibrosis (CF) patients in clinical trials. The results in this report revealed that GSH altered the sensitivity of Pseudomonas aeruginosa to different antibiotics through pathways unrelated to the oxidative stress as generally perceived. In addition, GSH and its oxidized form inhibited the growth of P. aeruginosa.
ZHANG
YaNi
Y
Molecular Microbiology Laboratory, the College of Life Sciences, Northwest University, Xi'an 710069, China.
DUAN
KangMin
K
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D019803:Glutathione Disulfide / Q000378:metabolism; D005981:Glutathione Synthase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013752:Tetracycline / Q000378:metabolism / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D017382:Reactive Oxygen Species; D005981:Glutathione Synthase; D013752:Tetracycline; D005978:Glutathione; D019803:Glutathione Disulfide