A long-term retrospective review of 5 cases using daptomycin for prosthetic device infections after surgery.
OBJECTIVE
To review the antimicrobial possibilities for limb-sparing due to infectious complications after surgery in patients diagnosed with osteosarcoma and with implantation of prosthetic devices. PATIENTS AND PROGRESS: After several episodes of relapsing infection or even re-infection and failure of previous therapies, 5 patients (2 young, female / 1 young, male / 2 middle-aged, female) were subject to a long-term ambulatory regimen consisting of intravenous administration of daptomycin.


RESULTS
Showed improved outcome with preservation of the limbs or devices involved.


CONCLUSIONS
Five patients with post-operative gram-positive suspected infections of prosthetic devices that were unresponsive to a variety of other antibiotics and combinations appeared to respond to compassionate use of daptomycin. its effectiveness is probably due to its activity against biofilmproducing microorganisms. Controlled, double-blind randomized trials are needed to confirm the potential of daptomycin in such patients.
Quetglas
Emilio G
EG
Emergency Department, Clinical Pharmacology Service, University Clinic of Navarra, Pamplona. egquetglas@unav.es
San Julian
Mikel
M
Garcia Tutor
Emilio
E
Vazquez
Blanca
B
Lucena
Felipe
F
Landecho
Manuel
M
Azanza
Jose Ramon
JR
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000601:surgery*; D018427:Breast Implants / Q000009:adverse effects*; D017576:Daptomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005266:Femoral Neoplasms / Q000601:surgery; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000601:surgery*; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents; D017576:Daptomycin