title: [Prevalence change of HGV(GBV-C) infection and its coinfection with HBV a HCV infections in haemodialysis patients].
abstract: Prevalence of HGV(GBV-C) infection and its coinfection with HBV a HCV infections were studied in group of 82 haemodialysis patients. This study was realized 20 months latter again -- 16 patients from 82 were running in dialysis, 17 patients were transplanted and 49 patients died (non of this viruses was cause of their death). HGV(GBV-C) RNA was detected in serum of 22 patients, 20 months latter it was detected in serum of 3 patients; one positive was new. 20 months latter any HGV(GBV-C) RNA was not detected in serum of 4 originally positive patients. Three of ten HBsAg positive patients were coinfected by HGV(GBV-C) RNA; 20 months latter any coinfection was found. In the first we found HGV(GBV-C) RNA in serum of 5 anti-HCV positive patients and in serum of 1 HCV RNA positive patient; 20 months latter it was in serum of 1 and 1 respectively. Elevation of ALT and AST levels were found in serum of 3 from 82 patients; two patients were coinfected with HBV or HCV. Any from 2 running dialysis patients with elevation of ALT and AST levels was not HGV(GBV-C) RNA positive. This virus is not probably frequent cause of liver disease in dialysis patients and it is not necessary to routinely screen for HGV(GBV-C) infection in this group of patients.
authors: Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra biologických a lékarských ved. klusono@faf.cuni.cz
authors: Hana
authors: H
authors: Klusonová
authors: Vlasta
authors: V
authors: Stepánová
authors: Lenka
authors: L
authors: Plísková
authors: Roman
authors: R
authors: Stilec
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D018178:Flaviviridae Infections / Q000150:complications* / Q000175:diagnosis; D029407:GB virus C / Q000302:isolation & purification; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis; D006435:Renal Dialysis; D012698:Serologic Tests
chemical_list: D012367:RNA, Viral