Characterization of pHEMA-based hydrogels that exhibit light-induced bactericidal effect via release of NO.
A light-activated NO donor, [Mn(PaPy(3))(NO)]ClO(4) (1a), has been incorporated into HEMA-based polymer hydrogel and the nitrosyl-polymer conjugate materials 1a(x) · HG and 1a(x) · HG(MB) have been characterized. The NO releasing properties and antibacterial capabilities of these materials in conjunction with growth attenuators such as hydrogen peroxide and methylene blue (MB) are reported. Since the nitrosyl releases NO only upon exposure to light, materials like 1a(x) · HG(MB) could be used as wound dressings that deliver NO under controlled conditions.
Halpenny
Genevieve M
GM
Department of Chemistry and Biochemistry, University of California at Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.
Steinhardt
Rachel C
RC
Okialda
Krystle A
KA
Mascharak
Pradip K
PK
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000378:metabolism; D001458:Bandages; D004396:Coloring Agents / Q000737:chemistry; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000378:metabolism; D020100:Hydrogels / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D008027:Light; D008264:Macrophages / Q000378:metabolism; D008422:Materials Testing; D008670:Metals / Q000737:chemistry; D008751:Methylene Blue / Q000737:chemistry; D008956:Models, Chemical; D009569:Nitric Oxide / Q000737:chemistry*; D010777:Photochemistry / Q000379:methods; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry*; D014945:Wound Healing
D000900:Anti-Bacterial Agents; D004396:Coloring Agents; D020100:Hydrogels; D008670:Metals; D011102:Polyhydroxyethyl Methacrylate; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D008751:Methylene Blue