Comparison of the prognostic value of tumour- and patient-related factors in patients undergoing potentially curative surgery for colon cancer.
OBJECTIVE
To comprehensively compare the prognostic value of tumour- and patient-related factors in patients undergoing curative surgery for colon cancer.


METHODS
From a database of 287 patients who underwent elective resection between 1997 and 2005, tumour factors including stage and host factors including systemic inflammatory response [modified Glasgow Prognostic Score (mGPS)] were identified.


RESULTS
Median follow-up was 65 months. Over this period, 125 patients died, 80 from cancer. On multivariate analysis of all significant patient and tumour related factors, Dukes stage (P < 0.01), vascular invasion (P < 0.01) and the mGPS (P < 0.01) were independently associated with cancer-survival. Of the patient-related factors, age (P < 0.01), haemoglobin (P < 0.01), white-cell (P < 0.01), neutrophil (P < 0.01) and platelet (P < 0.01) counts, and alkaline phosphatase (P < 0.01) were most significantly associated with the mGPS.


CONCLUSIONS
In addition to tumour-related factors such as Dukes stage and vascular invasion, the preoperative mGPS should be included to guide prognosis in patients undergoing curative resection for colon cancer.
Roxburgh
C S D
CS
University Department of Surgery, Faculty of Medicine - University of Glasgow, Royal Infirmary, Glasgow, UK. campbellroxburgh@doctors.net.uk
Wallace
A M
AM
Guthrie
G K
GK
Horgan
P G
PG
McMillan
D C
DC
D000367:Age Factors; D000368:Aged; D000469:Alkaline Phosphatase / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001772:Blood Cell Count; D002423:Cause of Death; D016009:Chi-Square Distribution; D003110:Colonic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors
D015415:Biomarkers; D006454:Hemoglobins; D000469:Alkaline Phosphatase