title: Multiplicity of DNA end resection machineries in chromosome break repair.
abstract: DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues (pp. 1423-1437) published in the June 15, 2009, issue of Genes & Development identified a novel mycobacterial DNA end resection protein complex, AdnAB, that harbors dual DNA motor and dual nuclease functions. Sinha and colleagues also demonstrated that the DNA end-binding protein complex Ku regulates the activity of AdnAB.
authors: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors: Hengyao
authors: H
authors: Niu
authors: Steven
authors: S
authors: Raynard
authors: Patrick
authors: P
authors: Sung
mesh_terms: D001105:Archaea / Q000235:genetics; D001419:Bacteria / Q000201:enzymology / Q000235:genetics; D001426:Bacterial Proteins / Q000378:metabolism; D019457:Chromosome Breakage; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000502:physiology*; D005057:Eukaryotic Cells / Q000378:metabolism; D043211:Exodeoxyribonuclease V / Q000378:metabolism; D005090:Exodeoxyribonucleases / Q000378:metabolism; D009161:Mycobacterium / Q000201:enzymology* / Q000235:genetics*; D011387:Prokaryotic Cells / Q000378:metabolism; D053484:RecQ Helicases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D005090:Exodeoxyribonucleases; C407424:AddAB enzyme; C070765:recJ protein, Bacteria; D043211:Exodeoxyribonuclease V; D053484:RecQ Helicases