title: Exceptional brain aging in a rural population-based cohort.
abstract: BACKGROUND
  The 2000 US Census identified 50,454 Americans over the age of 100. Increased longevity is only of benefit if accompanied by maintenance of independence and quality of life. Little is known about the prevalence of dementia and other disabling conditions among rural centenarians although this information is important to clinicians caring for them.
  
  
  OBJECTIVE
  To determine the prevalence of disabling conditions, including cognitive impairment, among the very elderly in a rural setting to guide clinicians in their care.
  
  
  METHODS
  We performed a population-based cohort study of all residents 97 years and older in the Klamath Basin, a rural region in southern Oregon. The prevalence of disabling conditions was determined by in-person examination.
  
  
  RESULTS
  About 100% of the target sample was identified. Of the eligible 67 individuals > or =97 years old, 31 were evaluated in-person. The prevalence of dementia (probable or possible Alzheimer's disease or vascular dementia) was 61.3% (95% CI: 43.8, 76.2), mild cognitive impairment was 29.0% (95% CI: 16.1, 46.6), and no dementia was 9.7% (95% CI: 3.4, 25.0). Parkinsonism and the APOEe4 allele were rare. Systemic vascular disease was almost universally present.
  
  
  CONCLUSIONS
  While cognitive impairment was nearly universal in this rural population of very elderly persons, almost 40% had not progressed to full dementia. Determining risk factors for dementia in this population can identify strategies to prevent progression to dementia among younger elderly populations.
authors: Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
authors: Jeffrey
authors: J
authors: Kaye
authors: Yvonne
authors: Y
authors: Michael
authors: James
authors: J
authors: Calvert
authors: Marjorie
authors: M
authors: Leahy
authors: Debbie
authors: D
authors: Crawford
authors: Patricia
authors: P
authors: Kramer
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001921:Brain; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology*; D009922:Oregon / Q000453:epidemiology; D012424:Rural Population