title: Voxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsy.
abstract: We aim to investigate structural brain abnormalities in juvenile myoclonic epilepsy (JME) patients with photosensitivity (PS). Sixty JME patients, 19 (32%) of whom were photosensitive, were submitted to 1.5T magnetic resonance voxel-based morphometry (VBM). The control group (CTL) consisted of 30 sex-matched healthy volunteers. JME patients with (JME-PS) and without (JME-NPS) PS did not differ in their duration of disease, treatment or seizure control. VBM revealed significantly reduced bilateral gray matter volume (GMV) in thalami, insula cortices and cerebellar hemispheres; while significantly increased GMV was observed in the right superior frontal, orbitofrontal and medial frontal gyri of the JME group compared to CTL. JME-PS had reduced bilateral GMV of visual cortices when compared with CTL; while it was not seen among JME-NPS patients. Reduced left hippocampus and left inferior frontal gyrus volume was observed among JME-PS compared with JME-NPS. This study demonstrates structural abnormalities beyond the limits of the frontal lobes and provides evidence for the role of the occipital cortex in human PS, reinforcing the existence of functional-anatomic ictogenic networks in JME and the concept of 'system epilepsies'.
authors: Unidade de Pesquisa e Tratamento das Epilepsias, Universidade Federal de São Paulo (UNIFESP-EPM), São Paulo, SP, Brazil. linkatia@uol.com.br
authors: Katia
authors: K
authors: Lin
authors: Andrea Parolin
authors: AP
authors: Jackowski
authors: Henrique
authors: H
authors: Carrete
authors: Gerardo Maria
authors: GM
authors: de Araújo Filho
authors: Henrique Hattori
authors: HH
authors: Silva
authors: Mirian Salvadori Bittar
authors: MS
authors: Guaranha
authors: Laura Maria Figueiredo Ferreira
authors: LM
authors: Guilhoto
authors: Rodrigo Affonseca
authors: RA
authors: Bressan
authors: Elza Márcia Targas
authors: EM
authors: Yacubian
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020190:Myoclonic Epilepsy, Juvenile / Q000150:complications / Q000473:pathology*; D009929:Organ Size; D018579:Patient Selection; D020795:Photophobia / Q000150:complications / Q000473:pathology*