Polymorphisms in the Renin-Angiotensin system and outcome of very-low-birthweight infants.
BACKGROUND
The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity.


OBJECTIVE
To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants.


METHODS
Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively.


RESULTS
There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus.


CONCLUSIONS
Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.
Spiegler
J
J
Department of Pediatrics, University of Lubeck, Lubeck, Germany. spiegler@paedia.ukl.mu-luebeck.de
Gilhaus
A
A
Konig
I R
IR
Kattner
E
E
Vochem
M
M
Kuster
H
H
Moller
J
J
Muller
D
D
Kribs
A
A
Segerer
H
H
Wieg
C
C
Nikischin
W
W
von der Wense
A
A
Gebauer
C
C
Herting
E
E
Gopel
W
W
D000328:Adult; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000235:genetics*; D019102:Infant, Very Low Birth Weight / Q000502:physiology*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012084:Renin-Angiotensin System / Q000235:genetics*