Polymer-mesoporous silica materials templated with an oppositely charged surfactant/polymer system for drug delivery.
In this paper, polymer-mesoporous silica nanoparticles have been synthesized by a dual-template technology. Cationic polymer quaternized poly[bis(2-chloroethyl)ether-alt-1,3-bis[3-(dimethylamino)propyl]urea] (PEPU) and anionic surfactant sodium dodecyl sulfate (SDS) were used to form a homogeneous comicelle system to induce mesoporous silica spherical nanoparticles with diameters of 50-180 nm. The formation mechanism was studied by transmission electron microscopy (TEM), which suggested that PEPU played a cotemplate role in the synthesis process, and no mesoporous structure was generated without it. After removing the anionic surfactant, SDS, by an ion-exchange method, the cationic polymer-mesoporous silica nanoparticles were obtained. Using the materials as the host and ibuprofen (IBU)/captopril (CapH(2)) as the model drugs, the system revealed well-sustained release profiles.
Lin
Huiming
H
State Key Laboratory for Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, China.
Zhu
Guangshan
G
Xing
Jiaojiao
J
Gao
Bo
B
Qiu
Shilun
S
D000327:Adsorption; D002216:Captopril / Q000737:chemistry; D002412:Cations; D016503:Drug Delivery Systems; D007052:Ibuprofen / Q000737:chemistry; D007477:Ions; D008855:Microscopy, Electron, Scanning / Q000379:methods; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008956:Models, Chemical; D009584:Nitrogen / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011312:Pressure; D012822:Silicon Dioxide / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D014961:X-Ray Diffraction
D002412:Cations; D007477:Ions; D011108:Polymers; D013501:Surface-Active Agents; D012822:Silicon Dioxide; D002216:Captopril; D009584:Nitrogen; D007052:Ibuprofen