title: Anal pressure in experimental diabetes.
abstract: OBJECTIVE
  Diabetes mellitus is a metabolic endocrine disorder that affects many systems, the gastrointestinal system often being among the affected systems. This experimental study work was designed to demonstrate altered anal sphincter pressures in an experimental model of diabetes mellitus (DM).
  
  
  METHODS
  Male Wistar rats (mean weight = 250 g) were used and randomized in two groups (n = 10): CO = control and DM. DM was induced by administering a single dose of streptozotocin. Glycemic levels were measured at the start (time = 0) and end (time = 60) of the experiment and anorectal manometry at the end.
  
  
  RESULTS
  DM rats presented a significant increase in glycemia at day 60 (DM = 407.14 +/- 73.76) as compared to the control group (time 0 = 175.7 +/- 18.62 and time 60 = 198.04 +/- 28.66). Anorectal manometry showed a significant decrease in anal pressure in the DM group at day 60 (DM = 34.2 +/- 4.97) as compared to the CO group at the same time (CO = 67.4 +/- 2.06), with P < 0.01 and P < 0.001 (Student's t test).
  
  
  CONCLUSIONS
  The results suggest that DM, due to the high glycemic levels, lead to alterations such as anal sphincter hypotony, which may cause complications such as fecal incontinence.
authors: Laboratory of Experimental Hepatology-Physiology, Hospital de Clínicas de Porto Alegr (HCPA)/Federal University of Rio Grande do Sul (UFRGS), Rio Grande do Sul, Brazil.
authors: Juliana
authors: J
authors: Tieppo
authors: Nélson A
authors: NA
authors: Kretzmann Filho
authors: Maura
authors: M
authors: Seleme
authors: Henrique S
authors: HS
authors: Fillmann
authors: Bary
authors: B
authors: Berghmans
authors: Norma
authors: N
authors: Possa Marroni
mesh_terms: D001003:Anal Canal / Q000503:physiopathology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D008365:Manometry; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose