Depression in frontotemporal dementia.
OBJECTIVE
The authors describe mood abnormalities seen in a case series of patients with frontotemporal dementia (FTD).


METHODS
Authors provide a structured review of outpatient and inpatient charts of FTD patients.


RESULTS
Three distinct depressive syndromes were identified: The first corresponds to DSM-IV major depression. The second is a syndrome of mood lability with prominent responsiveness to the environment. The third is a syndrome of profound apathy, without other evidence of depression.


CONCLUSIONS
A variety of mood disorders are seen in FTD, requiring careful attention to differential diagnosis. FTD should be included in the differential diagnosis during the evaluation of older patients with mood abnormalities.
Blass
David M
DM
Abarbanel Mental Health Center, 15 Keren Kayemet St., Bat Yam, Israel. dmblass@jhmi.edu
Rabins
Peter V
PV
D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D003937:Diagnosis, Differential; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009042:Motivation; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D012931:Social Environment
D000928:Antidepressive Agents