[Urine-based cytological diagnosis against the background of the new histopathological classification].
Urinary cytology is a basic adjunct to cystoscopy and transurethral resection in the diagnosis and characterization of high-grade urothelial carcinomas of the bladder. According to the new WHO classification the former tumor grading G1-3 for non-invasive carcinomas has been replaced by a separation into low-grade and high-grade urothelial carcinomas. An interesting question is where the former non-invasive G2 carcinomas will be positioned in this new classification. In a retrospective analysis we focused on 44 patients with pTaG2 and 17 patients with pT1G2 carcinomas and found that this group of tumors is cytologically heterogeneous but easily differentiated into low-grade and high-grade lesions. A cytometrical analysis significantly underlines the results of the cytological diagnostics. High-grade tumors show a higher recurrence and progression rate. Cytological diagnostics can therefore assist in differentiating low-grade from high-grade urothelial carcinomas.
Tschirdewahn
S
S
Klinik und Poliklinik für Urologie, Kinderurologie und urologische Onkologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122 , Essen, Deutschland.
Boergermann
C
C
Becker
M
M
Szarvas
T
T
Rübben
H
H
vom Dorp
F
F
D000328:Adult; D002295:Carcinoma, Transitional Cell / Q000145:classification* / Q000473:pathology* / Q000652:urine; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000145:classification* / Q000473:pathology* / Q000652:urine; D014556:Urine / Q000166:cytology*; D055815:Young Adult