title: Prospective trial to evaluate staged neck dissection or elective neck radiotherapy in patients with CT-staged T1-2 N0 squamous cell carcinoma of the oral tongue.
abstract: BACKGROUND
  A prospective study was undertaken to evaluate a policy of selective, single-modality elective neck treatment in T1-2, node-negative oral tongue squamous cell carcinoma.
  
  
  METHODS
  Where the primary tumor showed 1 of the 4 key pathological criteria (greater than 7 mm of muscle invasion, less than 5 mm of resection margin, perineural or lymphovascular invasion), radiotherapy was delivered to the primary site and the at-risk undissected neck. Otherwise patients underwent ipsilateral neck dissection within 4 weeks of initial resection. Prospective quality of life assessments were performed.
  
  
  RESULTS
  The study was closed after accrual of 25 patients, because the high locoregional recurrence rate met early stopping criteria. With a median follow-up of 3.4 years, the locoregional recurrence rate was 23%. The 4-year overall and disease-free survival rates were 71% and 64%, respectively.
  
  
  CONCLUSIONS
  The poor disease-free survival reflects the need for better prognostic markers and more aggressive treatment in these patients.
authors: Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. sinead.brennan@slh.ie
authors: Sinead
authors: S
authors: Brennan
authors: June
authors: J
authors: Corry
authors: Stephen
authors: S
authors: Kleid
authors: Sandro
authors: S
authors: Porceddu
authors: Kally
authors: K
authors: Yuen
authors: Danny
authors: D
authors: Rischin
authors: Lester J
authors: LJ
authors: Peters
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging / Q000379:methods; D011446:Prospective Studies; D011788:Quality of Life; D014057:Tomography, X-Ray Computed