title: Tissue persistence of fumonisin B1 in ducks and after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds.
abstract: Toxicity and persistence of fumonisin B1 (FB1) in liver, kidney and muscle were investigated in ducks fed 5, 10 and 20mg FB1+FB2/kg feed during force-feeding. Mortality and signs of toxicity were only obtained with 20mg/kg, whereas an increased Sa/So ratio was observed from 5mg/kg on. Persistence of FB1 was only found in liver (16 and 20 microg FB1/kg liver in ducks fed 10 and 20 mg FB1+FB2/kg feed, respectively). Toxicokinetic studies were conducted by the intravenous route (IV, single dose: 10mg FB1/kg body weight) and the oral route (single dose: 100mg FB1/kg body weight), in growing ducks and in ducks during force-feeding. After IV administration, serum concentration-time curves were described by a two-compartment open model. Elimination half-life and mean residence time of FB1 were 26 and 24 min, respectively, clearance was 19.3 ml/min/kg. After oral administration, bioavailability, elimination half-life, mean residence time and clearance varied during force-feeding and growth from 2-2.3%, 71-80 min, 200-188 min, 16.7-17 ml/min/kg, respectively. Taken together these results demonstrate that the risk of persistence of FB1 in ducks after force-feeding is very low, Sa/So being a good biomarker which increases before signs of toxicity and risk of persistence of FB1 in tissue (limit of detection 13 microg/kg).
authors: ENVT, Mycotoxicology Unit, 23 chemin des capelles, BP 87614, 31076 Toulouse Cedex 3, France.
authors: Didier
authors: D
authors: Tardieu
authors: Jean-Denis
authors: JD
authors: Bailly
authors: Imad
authors: I
authors: Benlashehr
authors: Alienor
authors: A
authors: Auby
authors: Jean-Yves
authors: JY
authors: Jouglar
authors: Philippe
authors: P
authors: Guerre
mesh_terms: D000821:Animal Feed / Q000009:adverse effects*; D000818:Animals; D004372:Ducks / Q000378:metabolism*; D037341:Fumonisins / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D005670:Fusarium / Q000737:chemistry; D008297:Male
chemical_list: D037341:Fumonisins; C056933:fumonisin B1