title: Physiologically based pharmacokinetic (PBPK) modeling and simulation: applications in lead optimization.
abstract: Physiologically based pharmacokinetics (PBPK) models are increasingly being used in the lead optimization (LO) process. Although there are currently few literature reports of the application of PBPK, the scope of PBPK modeling is expanding and there is a steady increase in the number of publications in this field. Recent publications covering four important areas of the application of PBPK modeling in LO have been reviewed.
authors: Discovery DMPK, Astrazeneca R&D, Mölndal, Sweden. Sheila.Peters@astrazeneca.com
authors: Sheila Annie
authors: SA
authors: Peters
authors: Anna-Lena
authors: AL
authors: Ungell
authors: Hugues
authors: H
authors: Dolgos
mesh_terms: D000818:Animals; D003198:Computer Simulation; D055808:Drug Discovery / Q000379:methods*; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism; D010599:Pharmacokinetics; D010827:Physiology
chemical_list: D004364:Pharmaceutical Preparations