title: P(i-PrNCH2CH2)3N as a Lewis base catalyst for the synthesis of beta-hydroxynitriles using TMSAN.
abstract: Proazaphosphatrane 1a was found to be an efficient catalyst for synthesis of beta-hydroxynitriles via the reaction of trimethylsilylacetonitrile (TMSAN) with aldehydes under mild reaction conditions and typically low catalyst loading (ca. 2 mol %). A variety of functional groups were tolerated, and good to excellent product yields were obtained.
authors: Department of Chemistry, Gilman Hall, Iowa State University, Ames, Iowa 50011, USA.
authors: Kuldeep
authors: K
authors: Wadhwa
authors: John G
authors: JG
authors: Verkade