title: [Protective effect of puerarin on the secondary spinal cord injury in rats].
abstract: OBJECTIVE
  To research the protective effect of puerarin on secondary spinal cord injury (SCI) in rats.
  
  
  METHODS
  After the models of SCI were established by improved Allen's method on adult male SD rats, SOD, MDA, Bcl-2 and Bax gene protein expression between puerarin group and model group were compared after 1, 6, 12, 24 and 48 h.
  
  
  RESULTS
  Puerarin could significantly enhance the activity of SOD and reduce the content of MDA, increase the expression of Bcl-2 gene protein products and decrease Bax gene protein product.
  
  
  CONCLUSIONS
  Puerarin can increase the activity of SOD, reduce the content of MDA, promote the expession of Bcl-2 and restrain the expression of Bax in the early spinal cord injury. It has protective effect on the secondary spinal cord injury.
authors: Second Department of Orthopaedics, Second Affiliated Hospital, Medical School, Xi' an Jiaotong University, Xi' an 710004, China. henglisong1214@stu.xjtu.cdu.cn
authors: Li-Song
authors: LS
authors: Heng
authors: Bin-Shang
authors: BS
authors: Lan
authors: Zhen
authors: Z
authors: Jia
authors: Peng-Fei
authors: PF
authors: Wang
authors: Li-Ying
authors: LY
authors: Fan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry; D005786:Gene Expression Regulation / Q000187:drug effects; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000473:pathology*; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors; D051028:bcl-2-Associated X Protein / Q000378:metabolism
chemical_list: D000975:Antioxidants; D007529:Isoflavones; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D008315:Malondialdehyde; D013482:Superoxide Dismutase