title: Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia.
abstract: A methanol extract of the twigs of Cinnamomum cassia was found to possess inhibitory activity against tyrosinase. Purification of the MeOH extract afforded four new phenolics, cassiferaldehyde (6), icariside DC (9), cinnacassinol (10), and dihydrocinnacasside (13), together with 10 known compounds (1-5, 7-12, and 14). The structures of the new compounds were determined by spectroscopic data interpretation. Compounds 1-6 and 8-13 showed strong inhibitory activity against tyrosinase, with IC(50) values ranging from 0.24 to 0.94 mM.
authors: College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea.
authors: Tran Minh
authors: TM
authors: Ngoc
authors: IkSoo
authors: I
authors: Lee
authors: Do Thi
authors: do T
authors: Ha
authors: Hongjin
authors: H
authors: Kim
authors: ByungSun
authors: B
authors: Min
authors: KiHwan
authors: K
authors: Bae
mesh_terms: D032904:Cinnamomum aromaticum / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007723:Korea; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D006027:Glycosides; D010636:Phenols; D014442:Monophenol Monooxygenase