The small heat shock protein, HSPB6, in muscle function and disease.
The small heat shock protein, HSPB6, is a 17-kDa protein that belongs to the small heat shock protein family. HSPB6 was identified in the mid-1990s when it was recognized as a by-product of the purification of HSPB1 and HSPB5. HSPB6 is highly and constitutively expressed in smooth, cardiac, and skeletal muscle and plays a role in muscle function. This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications.
Dreiza
Catherine M
CM
Capstone Therapeutics, Tempe, AZ 85281, USA. cparmiter@hotmail.com
Komalavilas
Padmini
P
Furnish
Elizabeth J
EJ
Flynn
Charles R
CR
Sheller
Michael R
MR
Smoke
Christopher C
CC
Lopes
Luciana B
LB
Brophy
Colleen M
CM
D000595:Amino Acid Sequence; D000818:Animals; D001249:Asthma / Q000378:metabolism; D050886:HSP20 Heat-Shock Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010748:Phosphopeptides; D051381:Rats; D015398:Signal Transduction; D013345:Subarachnoid Hemorrhage / Q000378:metabolism
D050886:HSP20 Heat-Shock Proteins; C494382:HSPB6 protein, human; D010748:Phosphopeptides