title: [Fibrotic remodeling of nasal mucosa in rat model after radiation injury].
abstract: OBJECTIVE
  To investigate the role of nasal mucosa fibrosis on radiation induced nasal mucosa injury.
  
  
  METHODS
  Seventy two male rats were randomly divided into two groups, control group and irradiation injured group (radiation dose were 40 Gy); the rats were killed 1 week, 2 weeks, 4 weeks, 8 weeks, 3 months and 6 months after the finish of radiation. The middle turbinates of the animals were removed. The pathological change of the nasal mucosa were observed with scanning electron microscope, transmission electron microscope, hematoxylin and eosin (HE), alcian blue-periodic acid-Schif (AB-PAS), and Masson Trichrome (MT). The Hyp content in nasal mucosa was measured with chemo-chromatometry.
  
  
  RESULTS
  After radiation, the pathological characteristics in early stage (within 4 weeks) was acute inflammatory reaction. The repair of nasal mucosa started 4 weeks after radiation, lasted to 6 months. The deposition of collagen in nasal mucosa could be found 1 week after irradiation and increased gradually.
  
  
  CONCLUSIONS
  Irradiation could induce a serials of pathological changes on nasal mucosa. The nasal mucosa fibrosis may be one of the reasons of persistent irradiation induced nasal mucosa injury.
authors: Department of Otorhinolaryngology Head and Neck Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou 310016, China.
authors: Mang
authors: M
authors: Xiao
authors: Jian-Guo
authors: JG
authors: Tang
authors: Xiao-Nan
authors: XN
authors: Sun
authors: Xiu-Wen
authors: XW
authors: Jiang
authors: Bao-Zhen
authors: BZ
authors: Luo
authors: Li-Na
authors: LN
authors: Zhao
mesh_terms: D000818:Animals; D005355:Fibrosis; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology*; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing