title: Occupational exposure to polycyclic aromatic hydrocarbons and DNA damage by industry: a nationwide study in Germany.
abstract: Exposure to polycyclic aromatic hydrocarbons (PAH) and DNA damage were analyzed in coke oven (n = 37), refractory (n = 96), graphite electrode (n = 26), and converter workers (n = 12), whereas construction workers (n = 48) served as referents. PAH exposure was assessed by personal air sampling during shift and biological monitoring in urine post shift (1-hydroxypyrene, 1-OHP and 1-, 2 + 9-, 3-, 4-hydroxyphenanthrenes, SigmaOHPHE). DNA damage was measured by 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and DNA strand breaks in blood post shift. Median 1-OHP and SigmaOHPHE were highest in converter workers (13.5 and 37.2 microg/g crea). The industrial setting contributed to the metabolite concentrations rather than the air-borne concentration alone. Other routes of uptake, probably dermal, influenced associations between air-borne concentrations and levels of PAH metabolites in urine making biomonitoring results preferred parameters to assess exposure to PAH. DNA damage in terms of 8-oxo-dGuo and DNA strand breaks was higher in exposed workers compared to referents ranking highest for graphite-electrode production. The type of industry contributed to genotoxic DNA damage and DNA damage was not unequivocally associated to PAH on the individual level most likely due to potential contributions of co-exposures.
authors: BGFA-Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany.
authors: Boleslaw
authors: B
authors: Marczynski
authors: Beate
authors: B
authors: Pesch
authors: Michael
authors: M
authors: Wilhelm
authors: Bernd
authors: B
authors: Rossbach
authors: Ralf
authors: R
authors: Preuss
authors: Jens-Uwe
authors: JU
authors: Hahn
authors: Sylvia
authors: S
authors: Rabstein
authors: Monika
authors: M
authors: Raulf-Heimsoth
authors: Albrecht
authors: A
authors: Seidel
authors: Hans-Peter
authors: HP
authors: Rihs
authors: Ansgar
authors: A
authors: Adams
authors: Michael
authors: M
authors: Scherenberg
authors: Anja
authors: A
authors: Erkes
authors: Beate
authors: B
authors: Engelhardt
authors: Kurt
authors: K
authors: Straif
authors: Heiko Udo
authors: HU
authors: Käfferlein
authors: Jürgen
authors: J
authors: Angerer
authors: Thomas
authors: T
authors: Brüning
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D003077:Coke / Q000032:analysis; D004249:DNA Damage; D005858:Germany; D006801:Humans; D007221:Industry / Q000706:statistics & numerical data; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D010616:Phenanthrenes / Q000032:analysis; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000633:toxicity*; D011721:Pyrenes / Q000032:analysis; D055815:Young Adult
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D003077:Coke; D010616:Phenanthrenes; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C031181:phenanthrene; C030984:pyrene