title: Myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with diffuse tubulointerstitial nephritis.
abstract: Renal involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is characterized by focal segmental crescentic and/or necrotizing glomerulonephritis. Here, we report the case of a 66-year-old woman showing myeloperoxidase (MPO)-ANCA positivity and mononeuritis multiplex whose kidney biopsy revealed severe and diffuse tubulointerstitial nephritis despite the fact that crescentic necrotizing glomerulonephritis was focal. The mechanism of tubulointerstitial injury in ANCA-associated vasculitis remains unclear. Further studies are necessary to confirm the relationship between diffuse tubulointerstitial nephritis and ANCA-associated vasculitis.
authors: Department of Nephrology and Endocrinology, University of Tokyo, Tokyo - Japan.
authors: Daisuke
authors: D
authors: Son
authors: Hiroko
authors: H
authors: Kanda
authors: Akihiro
authors: A
authors: Yamaguchi
authors: Kimito
authors: K
authors: Kawabata
authors: Takahisa
authors: T
authors: Kawakami
authors: Kanae
authors: K
authors: Kubo
authors: Mana
authors: M
authors: Higashihara
authors: Jun
authors: J
authors: Shimizu
authors: Hiroshi
authors: H
authors: Uozaki
authors: Shigeru
authors: S
authors: Kuramochi
authors: Yoshikata
authors: Y
authors: Misaki
authors: Fujio
authors: F
authors: Takeuchi
authors: Kazuhiko
authors: K
authors: Yamamoto
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D009395:Nephritis, Interstitial / Q000209:etiology / Q000473:pathology*; D009195:Peroxidase / Q000276:immunology*; D014657:Vasculitis / Q000209:etiology / Q000473:pathology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase