title: A cascade approach to cyclic aminonitrones: reaction discovery, mechanism, and scope.
abstract: Treatment of omega-epoxynitriles with hydroxylamine affords cyclic aminonitrones in a single step and with high stereoselectivity. The scope of this novel transformation was explored in a series of examples. The aminonitrone products were shown to be useful substrates for further selective elaboration.
authors: Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA.
authors: Rojita
authors: R
authors: Sharma
authors: Paul G
authors: PG
authors: Bulger
authors: Michael
authors: M
authors: McNevin
authors: Peter G
authors: PG
authors: Dormer
authors: Richard G
authors: RG
authors: Ball
authors: Eric
authors: E
authors: Streckfuss
authors: James F
authors: JF
authors: Cuff
authors: Jingjun
authors: J
authors: Yin
authors: Cheng-yi
authors: CY
authors: Chen
mesh_terms: D018360:Crystallography, X-Ray; D003500:Cyclization; D015195:Drug Design; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry; D000068898:Raltegravir Potassium
chemical_list: D019428:HIV Integrase Inhibitors; D011744:Pyrimidinones; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium