Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.
Two new dihydropyranocoumarins, scuteflorins A (1) and B (2), together with the known compounds decursin (3), chrysin (4), oroxylin A (5), wogonin (6), 5,7-dihydroxy-8,2'-dimethoxyflavone, dihydrochrysin, dihydrooroxylin A, lupenol, scutellaric acid, pomolic acid, ursolic acid, beta-sitosterol, daucosterol, and palmitic acid, were isolated from the aerial parts of Scutellaria lateriflora, commonly used as a dietary supplement. The structures of 1 and 2 were established by means of 1D and 2D NMR spectra as well as HRMS data. The absolute configuration of coumarins 1 and 2 was determined by comparison of experimental and theoretical calculated CD spectra. The cytotoxicity and antioxidant effects of the methanol extract of this plant and some of the constituent flavonoids were evaluated in vitro.
Li
Jing
J
Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
Ding
Yuanqing
Y
Li
Xing-Cong
XC
Ferreira
Daneel
D
Khan
Shabana
S
Smillie
Troy
T
Khan
Ikhlas A
IA
D000465:Algorithms; D000818:Animals; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D018922:HL-60 Cells; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D039681:Pyranocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014709:Vero Cells
D044950:Flavanones; D005419:Flavonoids; D039681:Pyranocoumarins; C043561:chrysin; C080669:5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one; C541668:scuteflorin A; C085514:wogonin