Stereocontrolled routes to beta,beta'-disubstituted alpha-amino acids.
Owing to their significant abundance in natural products, chiral beta,beta'-disubstituted alpha-amino acids remain an important synthetic objective. Emphasis has been focused in this critical review on the great diversity of enantio- and diastereoselective methodologies to reach these highly functionalized compounds. The oldest and cutting edge synthetic methods are described in parallel with the synthesis of many relevant biologically active targets (224 references).
Michaux
Julien
J
Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Niel
Gilles
G
Campagne
Jean-Marc
JM
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry; D001388:Aziridines / Q000138:chemical synthesis / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
D000596:Amino Acids; D001384:Azetidines; D001388:Aziridines; D007097:Imines; D005998:Glycine