A simple and efficient access to alpha-amino phosphonates from N-benzyloxycarbonylamino sulfones using indium(III) chloride.
Treatment of N-benzyloxycarbonylamino sulfones with triethyl phosphite catalyzed by InCl3 produces the corresponding protected alpha-amino phosphonates in high yields (71-92%).
Das
Biswanath
B
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. biswanathdas@yahoo.com
Damodar
Kongara
K
Bhunia
Nisith
N
D001593:Benzyl Compounds / Q000737:chemistry*; D002384:Catalysis; D007204:Indium / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry*
D001593:Benzyl Compounds; C545174:N-benzyloxycarbonylamino sulfone; D063065:Organophosphonates; D013450:Sulfones; D007204:Indium; C020758:indium trichloride