Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant (Camellia sinensis).
The MeOH extract and its BuOH-soluble fraction (crude saponin fraction) from the flower buds of Chinese tea plant (Camellia sinensis (L.) O. KUNTZE; Fujian Province) were found to exhibit accelerating effects on gastrointestinal transit in mice and inhibitory effects against pancreatic lipase. From the BuOH-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, chakasaponins I, II, and III (1-3, resp.), were isolated together with 13 known compounds. The chemical structures 1-3 were elucidated on the basis of chemical and physicochemical evidence. Compounds 1-3 showed accelerating effects on gastrointestinal transit in mice and inhibitory effects against porcine pancreatic lipase (IC(50)=150-530 microM).
Yoshikawa
Masayuki
M
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. myoshika@mb.kyoto-phu.ac.jp
Sugimoto
Sachiko
S
Kato
Yasuyo
Y
Nakamura
Seikou
S
Wang
Tao
T
Yamashita
Chihiro
C
Matsuda
Hisashi
H
D000215:Acylation; D000818:Animals; D028241:Camellia sinensis / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008297:Male; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013662:Tea / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D010936:Plant Extracts; D012503:Saponins; D013662:Tea; D014315:Triterpenes; C413246:oleanane; D009828:Oleanolic Acid; D008049:Lipase