Water-soluble rhamnose-coated Fe3O4 nanoparticles.
Water-soluble biocompatible rhamnose-coated Fe(3)O(4) nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.
Lartigue
Lenaic
L
Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-UM2, Chimie Moléculaire et Organisation du Solide, Université Montpellier II, Place E. Bataillon, 34095 Montpellier cedex 5, France.
Oumzil
Khalid
K
Guari
Yannick
Y
Larionova
Joulia
J
Guérin
Christian
C
Montero
Jean-Louis
JL
Barragan-Montero
Veronique
V
Sangregorio
Claudio
C
Caneschi
Andrea
A
Innocenti
Claudia
C
Kalaivani
T
T
Arosio
P
P
Lascialfari
A
A
D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006801:Humans; D037102:Lectins / Q000187:drug effects; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015394:Molecular Structure; D053758:Nanoparticles; D012210:Rhamnose / Q000737:chemistry*; D012867:Skin / Q000166:cytology / Q000187:drug effects; D012995:Solubility; D014867:Water / Q000737:chemistry
D003287:Contrast Media; D037102:Lectins; D014867:Water; D012210:Rhamnose; D052203:Ferrosoferric Oxide