Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potential.
Syntheses of 3,3-diheteroaromatic oxindole derivatives has been achieved by coupling indole-2,3-dione (isatin) with differently substituted indoles and pyrrole in presence of I(2) in i-PrOH. The in vitro spermicidal potentials and the mode of spermicidal action of the synthesized analogues were evaluated and the derivative, 3,3-bis (5-methoxy-1H-indol-3-yl) indolin-2-one (3d) exhibited most significant activity.
Paira
Priyankar
P
Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Jadavpur, Kolkata 700 032, India.
Hazra
Abhijit
A
Kumar
Shrabanti
S
Paira
Rupankar
R
Sahu
Krishnendu B
KB
Naskar
Subhendu
S
Saha
Pritam
P
Mondal
Shyamal
S
Maity
Arindam
A
Banerjee
Sukdeb
S
Mondal
Nirup B
NB
D000818:Animals; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D046529:Microscopy, Electron, Transmission; D000078183:Oxindoles; D051381:Rats; D013089:Spermatocidal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
C543971:3,3-bis(5-methoxy-1H-indol-3-yl)indolin-2-one; D007211:Indoles; D000078183:Oxindoles; D013089:Spermatocidal Agents; C022960:2-oxindole