Parathyroid hormone-dependent hypercalcemia.
The past fifteen years have resulted in great progress in our understanding of the pathogenesis and pathophysiology of hypercalcemic disorders occurring either sporadically or in a familial setting. This paper briefly reviews the clinically most important new knowledge on sporadic and hereditary forms of parathyroid hormone-dependent hypercalcemic disorders, with special emphasis on familial syndromes such as multiple endocrine neoplasia type 1 and type 2A, hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, familial hypocalciuric hypercalcemia and neonatal severe primary hyperparathyroidism. In addition, the authors briefly present the most important clinical characteristics of 141 patients with parathyroid hormone-dependent hypercalcemia, including index patients of 18 families with hereditary disorders, diagnosed in a Hungarian endocrine center between 1997 and 2007.
Toke
Judit
J
2nd Department of Medicine, Semmelweis University, Budapest, Hungary.
Patócs
Attila
A
Balogh
Katalin
K
Gergics
Péter
P
Stenczer
Balázs
B
Rácz
Károly
K
Tóth
Miklós
M
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology* / Q000601:surgery; D049950:Hyperparathyroidism, Primary / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology* / Q000601:surgery; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000601:surgery; D018813:Multiple Endocrine Neoplasia Type 2a / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood*; D011379:Prognosis; D044169:Receptors, Calcium-Sensing / Q000235:genetics / Q000502:physiology; D055815:Young Adult
D010281:Parathyroid Hormone; D044169:Receptors, Calcium-Sensing