Advances in dissecting mosquito innate immune responses to arbovirus infection.
Arthropod-borne viruses - arboviruses - are a significant threat to public health. Whilst there is considerable knowledge about arbovirus interactions with vertebrate immunity, relatively little is known about how vectors such as mosquitoes control arbovirus infections. In this review, we discuss novel findings in the field of mosquito antiviral responses to arboviruses, in particular RNA interference, the up-and-coming field of general immune-signalling pathways, and cell death/apoptosis.
Fragkoudis
Rennos
R
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK.
Attarzadeh-Yazdi
Ghassem
G
Nash
Anthony A
AA
Fazakerley
John K
JK
Kohl
Alain
A
D000818:Animals; D001102:Arbovirus Infections / Q000635:transmission / Q000821:virology*; D001103:Arboviruses / Q000276:immunology*; D009033:Culicidae / Q000235:genetics / Q000276:immunology* / Q000821:virology*; D006801:Humans; D007113:Immunity, Innate; D007303:Insect Vectors / Q000235:genetics / Q000276:immunology* / Q000821:virology