title: Is thermal nociception only sensed by the capsaicin receptor, TRPV1?
abstract: Mammalian heat pain perception is well documented as a molecular event in the primary afferent neurons expressing TRPV1. Six types of thermo-TRPs were found, i.e., TRPV1-4, TRPM8 and TRPA1. The former TRPV1, 2 and TRPV3, 4 are sensitive to noxious heat and warmth, and the latter two are sensitive to cool or cold, respectively. We attempted to provide a hypothesis to explain the paradox in which TRPV1 knockout mice and capsaicin-pretreated mice with severe loss of small dorsal root ganglion (DRG) neurons behave normally to noxious heat. From the general view that TRPV1 is preferentially expressed in C-fibers responding to a moderate thermal threshold (>43 degrees C) and TRPV2 in Adelta-fibers to high threshold temperatures (>52 degrees C), the above phenomenon is perplexing. Woodbury et al. (J Neurosci 24:6410-6415, 2004) offered two pain transduction mechanisms, one being TRPV1/2-independent and the other TRPV1-dependent. The former detects noxious heat under normal conditions without the presence of TRPV1 or TRPV2, and the latter requires TRPV1 under pathophysiological conditions. Unidentified isolectin B4 (IB4)-positive but TRPV1-negative small neurons with a higher noxious heat threshold are feasible, because a spliced isoform of TRPV1 responsive to noxious heat (47 degrees C) but not responsive to either proton or capsaicin is present in human and rat sensory neurons. Thus, the IB4-positive but TRPV1-negative small sensory neurons must have a crucial role in the noxious heat response.
authors: Department of Oral Anatomy, School of Dentistry, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima, 770-8504, Japan. hiuraaki@dent.tokushima-u.ac.jp
authors: Akio
authors: A
authors: Hiura
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000008:administration & dosage*; D006023:Glycoproteins / Q000378:metabolism; D006358:Hot Temperature; D051379:Mice; D018345:Mice, Knockout; D009619:Nociceptors / Q000187:drug effects / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse; C473590:isolectin B4-binding glycoprotein, mouse; D002211:Capsaicin