A simple and convenient copper-catalyzed tandem synthesis of quinoline-2-carboxylates at room temperature.
We developed a simple and convenient copper-catalyzed method for the synthesis of quinoline-2-carboxylate derivatives through sequential intermolecular addition of alkynes onto imines and subsequent intramolecular ring closure by arylation. The efficiency of this system allowed the reactions to be carried out at room temperature.
Huang
He
H
Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Jiang
Hualiang
H
Chen
Kaixian
K
Liu
Hong
H
D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
D000480:Alkynes; D007097:Imines; D009942:Organometallic Compounds; D011804:Quinolines; C059924:quinoline-4-carboxylic acid; D003300:Copper