title: Comparison of bacteriostatic and bactericidal activity of 13 essential oils against strains with varying sensitivity to antibiotics.
abstract: OBJECTIVE
  To compare the bacteriostatic and bactericidal activity of 13 chemotyped essential oils (EO) on 65 bacteria with varying sensitivity to antibiotics.
  
  
  RESULTS
  Fifty-five bacterial strains were tested with two methods used for evaluation of antimicrobial activity (CLSI recommendations): the agar dilution method and the time-killing curve method. EO containing aldehydes (Cinnamomum verum bark and Cymbopogon citratus), phenols (Origanum compactum, Trachyspermum ammi, Thymus satureioides, Eugenia caryophyllus and Cinnamomum verum leaf) showed the highest antimicrobial activity with minimum inhibitory concentration (MIC) <2% (v/v) against all strains except Pseudomonas aeruginosa. Alcohol-based EO (Melaleuca alternifolia, Cymbopogon martinii and Lavandula angustifolia) exhibited varying degrees of activity depending on Gram status. EO containing 1.8-cineole and hydrocarbons (Eucalyptus globulus, Melaleuca cajeputii and Citrus sinensis) had MIC(90%) > or = 10% (v/v). Against P. aeruginosa, only C. verum bark and O. compactum presented MIC < or =2% (v/v). Cinnamomum verum bark, O. compactum, T. satureioides, C. verum leaf and M. alternifolia were bactericidal against Staphylococcus aureus and Escherichia coli at concentrations ranging from to 0.31% to 10% (v/v) after 1 h of contact. Cinnamomum verum bark and O. compactum were bactericidal against P. aeruginosa within 5 min at concentrations <2% (v/v).
  
  
  CONCLUSIONS
  Cinnamomum verum bark had the highest antimicrobial activity, particularly against resistant strains.
  
  
  CONCLUSIONS
  Bacteriostatic and bactericidal activity of EO on nosocomial antibiotic-resistant strains.
authors: Antibiology Laboratory, CHU Hospital Nord, Saint-Etienne, France.
authors: L
authors: L
authors: Mayaud
authors: A
authors: A
authors: Carricajo
authors: A
authors: A
authors: Zhiri
authors: G
authors: G
authors: Aubert
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile