Increase of atypical lymphocytes expressing CD4+/CD45RO+ in an infectious mononucleosis-like syndrome associated with hepatitis A virus infection.
Subpopulations of regular and atypical lymphocytes in the peripheral blood of a 24-year-old man with an infectious mononucleosis (IM)-like syndrome associated with hepatitis A virus (HAV) infection were analyzed. The ratio of CD4+ to CD8+ cells was in the normal range (1.19 and 1.23 in the regular and atypical lymphocytes, respectively), with no increase in CD8+ cells. The percentage of CD8+/CD11b- cells was not increased in the atypical lymphocytes. However, CD45RO+ was expressed on 86.3% of CD4+ atypical lymphocytes. The present data suggest that atypical lymphocytes expressing CD4+/CD45RO+ may play the role of helper T cells in the immune system in the development of IM-like syndrome associated with HAV infection.
Watanabe
Hidehiro
H
Division of Respiratory Medicine, Machida Municipal Hospital, 2-15-41 Asahi-cho, Machida, Tokyo, 194-0023, Japan. Nabejprespir@aol.com
Sekine
Hideaki
H
Uruma
Tomonori
T
Nagasaki
Sai
S
Tsunoda
Tokuroh
T
Machida
Yutaka
Y
Kobayashi
Kentaro
K
Igarashi
Hisashi
H
D015704:CD4 Antigens / Q000276:immunology*; D016516:CD4-CD8 Ratio; D006506:Hepatitis A / Q000150:complications* / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000097:blood / Q000276:immunology* / Q000821:virology; D017493:Leukocyte Common Antigens / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D055815:Young Adult
D015704:CD4 Antigens; D017493:Leukocyte Common Antigens