Unfavorable blood rheology is closely associated with arterial stiffness in obese patients.
Little information on the relationship between blood rheology and atherosclerosis indicators in obese patients is available. We examined blood rheology as assessed by the blood passage time (BPT) with the microchannel method in 109 obese patients. BPT was correlated well with the extent of each metabolic syndrome component. A multivariate regression analysis revealed that the independent contributors to BPT were pulse-wave velocity, an index of arterial stiffness, body mass index and red blood cell. Furthermore, weight reduction intervention significantly decreased BPT. Assessment of rheology may be associated with pulse-wave velocity, and useful to manage obese patients.
Satoh
Noriko
N
Clinical Research Institute for Endocrine Metabolic Disease, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan. nsato@kyotolan.hosp.go.jp
Kotani
Kazuhiko
K
Wada
Hiromichi
H
Himeno
Akihiro
A
Shimada
Sayaka
S
Sasaki
Yousuke
Y
Yamada
Kazunori
K
Shimatsu
Akira
A
Hasegawa
Koji
K
D001783:Blood Flow Velocity; D002318:Cardiovascular Diseases / Q000209:etiology; D005260:Female; D018056:Hemorheology / Q000502:physiology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D011673:Pulsatile Flow / Q000502:physiology; D012307:Risk Factors; D014655:Vascular Resistance