Checkpoint regulation of DNA replication.
We discuss the mechanisms regulating entry into and progression through S phase in eukaryotic cells. Methods to study the G1/S transition are briefly reviewed and an overview of G1/S-checkpoints is given, with particular emphasis on fission yeast. Thereafter we discuss different aspects of the intra-S checkpoint and introduce the main molecular players and mechanisms.
Boye
Erik
E
Department of Cell Biology, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway.
Skjølberg
Henriette C
HC
Grallert
Beáta
B
D002453:Cell Cycle / Q000502:physiology*; D004249:DNA Damage; D004261:DNA Replication / Q000502:physiology*; D004271:DNA, Fungal / Q000096:biosynthesis; D016193:G1 Phase; D007700:Kinetics; D018741:Replication Origin; D016196:S Phase; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism; D012568:Schizosaccharomyces / Q000166:cytology / Q000378:metabolism
D004271:DNA, Fungal