title: Propofol clearance and volume of distribution are increased in patients with major burns.
abstract: Propofol pharmacokinetics were examined in 17 adults with major burns during the hyperdynamic convalescent phase. Eighteen nonburned surgical patients served as controls. After a 2-mg/kg intravenous dose of propofol, blood samples were collected at multiple time points. Noncompartmental methods were used to calculate the pharmacokinetic parameters. The following indices were higher in burns than controls: propofol clearance (64+/-17 vs 29+/-4 mL/kg/min, P<.001) and volume of distribution (8+/-3 vs 4+/-1 L/kg, P<.001). The area under the curve was smaller in burns (556+/-152 vs 1193+/-183 microg/mL h, P<.001). The higher clearance of propofol in burned patients may imply that these patients require higher doses or infusion rates of propofol to attain a target plasma concentration or pharmacodynamic effect.
authors: Department of Anesthesia, 5937 JPP, University of Iowa Hospitals and Clinics, Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA. anthony-han@uiowa.edu
authors: Tae-Hyung
authors: TH
authors: Han
authors: David J
authors: DJ
authors: Greenblatt
authors: J A Jeevendra
authors: JA
authors: Martyn
mesh_terms: D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics*; D002056:Burns / Q000188:drug therapy*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000493:pharmacokinetics*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol