title: I know where you'll look: an fMRI study of oculomotor intention and a change of motor plan.
abstract: BACKGROUND
  Electrophysiological studies in monkeys showed that the intention to perform a saccade and the covert change in motor plan are reflected in the neural activity of the posterior parietal cortex (PPC).
  
  
  METHODS
  To investigate whether such covert intentional processes are demonstrable in humans as well we used event related functional MRI. Subjects were instructed to fixate a central target, which changed its color in order to indicate the direction of a subsequent saccade. Unexpectedly for the subjects, the color changed again in half of the trials to instruct a spatially opposite saccade.
  
  
  RESULTS
  The double-cue induced synergistic and prolonged signals in early visual areas, the motion specific visual area V5, PPC, and the supplementary and frontal eye field. At the single subject level it became evident that the PPC split up in two separate subareas. In the posterior region, the signal change correlated with the change in motor plan: activation strongly decreased when the cue instructed an ipsiversive saccade while it strongly increased when it instructed a contraversive saccade. In the anterior region, the signal change was motor related irrespective of the spatial direction of the upcoming saccade.
  
  
  CONCLUSIONS
  Thus, the human PPC holds at least two different areas for planning and executing saccadic eye movements.
authors: Department of Neurology, Heinrich-Heine-University Düsseldorf, Moorenstr,5, 40225 Düsseldorf, Germany. raimund.kleiser@gespag.at.
authors: Raimund
authors: R
authors: Kleiser
authors: Christina S
authors: CS
authors: Konen
authors: Rüdiger J
authors: RJ
authors: Seitz
authors: Frank
authors: F
authors: Bremmer