title: Diastereoselective Synthesis of a Highly Substituted cis-Decahydroquinoline via a Knoevenagel Condensation.
abstract: A diastereoselective approach to 3,7,8-trisubstituted cis-decahydroquinolines is described. This ring system forms the core of rings B and E of the norditerpenoid alkaloid methyllycaconitine. This approach starts with a known disubsituted cyclohexene. The remaining carbons are attached via a Knoevenagel condensation followed by an intramolecular lactam formation. The stereochemistry of the substituents is controlled by the cis-substitution of the starting cyclohexene ring.
authors: Department of Chemistry & Biochemistry, Ohio University, Athens, Ohio, 45701, USA.
authors: Junfeng
authors: J
authors: Huang
authors: Stephen C
authors: SC
authors: Bergmeier