Aripiprazole-induced hiccups: a case report.
Hiccups can arise from idiopathic, psychogenic and organic causes. The use of therapeutic drugs forms one of the important causes of hiccups. Although the exact pathophysiological processes involved have not yet been established, the neurotransmitters dopamine, serotonin and gamma amino butyric aid (GABA) have been documented to play a significant role in the generation of hiccups. We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole. The possible underlying neurotransmitter mechanisms, predisposing factors and clinical implications of this rare adverse event are discussed.
Ray
Prasenjit
P
Central Institute of Psychiatry, Ranchi, India.
Zia Ul Haq
Mohammad
M
Nizamie
S Haque
SH
D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000378:metabolism; D000068180:Aripiprazole; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D002220:Carbamazepine / Q000009:adverse effects; D015984:Causality; D004298:Dopamine / Q000502:physiology; D004347:Drug Interactions; D006207:Half-Life; D016489:Head Injuries, Closed / Q000150:complications; D006606:Hiccup / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010879:Piperazines / Q000009:adverse effects* / Q000378:metabolism; D015363:Quinolones / Q000009:adverse effects* / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000502:physiology; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000187:drug effects / Q000502:physiology
D018692:Antimanic Agents; D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D000068180:Aripiprazole; D004298:Dopamine