Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?
Dietary restriction (DR) increases lifespan in a range of evolutionarily distinct species. The polyphenol resveratrol may be a dietary mimetic of some effects of DR. The pivotal role of the mammalian histone deacetylase (HDAC) Sirt1, and its homologue in other organisms, in mediating the effects of both DR and resveratrol on lifespan/ageing suggests it may be the common conduit through which these dietary interventions influence ageing. We propose the novel hypothesis that effects of DR relevant to lifespan extension include maintenance of DNA methylation patterns through Sirt1-mediated epigenetic effects, and proffer the view that dietary components, including resveratrol, may mimic these actions.
Wakeling
Luisa A
LA
Institute for Cell and Molecular Biosciences and Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK.
Ions
Laura J
LJ
Ford
Dianne
D
D000375:Aging / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004247:DNA / Q000235:genetics*; D019175:DNA Methylation; D004038:Diet, Reducing; D057890:Epigenomics / Q000379:methods*; D005247:Feeding Behavior / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008136:Longevity / Q000187:drug effects* / Q000235:genetics; D000077185:Resveratrol; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors; D056564:Sirtuin 1 / Q000096:biosynthesis / Q000235:genetics*; D013267:Stilbenes / Q000494:pharmacology*
D000975:Antioxidants; D013267:Stilbenes; D004247:DNA; D012264:Ribonucleotide Reductases; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077185:Resveratrol