title: Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi.
abstract: Mitogen-activated protein kinase (MAPK) cascades and the calcium-calcineurin pathway control fundamental aspects of fungal growth, development and reproduction. Core elements of these signalling pathways are required for virulence in a wide array of fungal pathogens of plants and mammals. In this review, we have used the available genome databases to explore the structural conservation of three MAPK cascades and the calcium-calcineurin pathway in ten different fungal species, including model organisms, plant pathogens and human pathogens. While most known pathway components from the model yeast Saccharomyces cerevisiae appear to be widely conserved among taxonomically and biologically diverse fungi, some of them were found to be restricted to the Saccharomycotina. The presence of multiple paralogues in certain species such as the zygomycete Rhizopus oryzae and the incorporation of new functional domains that are lacking in S. cerevisiae signalling proteins, most likely reflect functional diversification or adaptation as filamentous fungi have evolved to occupy distinct ecological niches.
authors: Departamento de Genética, Universidad de Córdoba, Córdoba, Spain.
authors: Nicolas
authors: N
authors: Rispail
authors: Darren M
authors: DM
authors: Soanes
authors: Cemile
authors: C
authors: Ant
authors: Robert
authors: R
authors: Czajkowski
authors: Anke
authors: A
authors: Grünler
authors: Romain
authors: R
authors: Huguet
authors: Elena
authors: E
authors: Perez-Nadales
authors: Anna
authors: A
authors: Poli
authors: Elodie
authors: E
authors: Sartorel
authors: Vito
authors: V
authors: Valiante
authors: Meng
authors: M
authors: Yang
authors: Roland
authors: R
authors: Beffa
authors: Axel A
authors: AA
authors: Brakhage
authors: Neil A R
authors: NA
authors: Gow
authors: Regine
authors: R
authors: Kahmann
authors: Marc-Henri
authors: MH
authors: Lebrun
authors: Helena
authors: H
authors: Lenasi
authors: José
authors: J
authors: Perez-Martin
authors: Nicholas J
authors: NJ
authors: Talbot
authors: Jürgen
authors: J
authors: Wendland
authors: Antonio
authors: A
authors: Di Pietro
mesh_terms: D019703:Calcineurin / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics*; D005658:Fungi / Q000235:genetics* / Q000378:metabolism*; D023281:Genomics; D006801:Humans; D020935:MAP Kinase Signaling System; D009181:Mycoses / Q000382:microbiology; D010935:Plant Diseases / Q000382:microbiology; D010944:Plants; D011494:Protein Kinases / Q000235:genetics; D015398:Signal Transduction
chemical_list: D005656:Fungal Proteins; D011494:Protein Kinases; D019703:Calcineurin; D002118:Calcium