title: Enantioselective hydrogenation of N-H imines.
abstract: N-H ketoimines 3a-3v are readily prepared in high yield via organometallic addition to nitriles and isolated as corresponding bench-stable hydrochloride salts. Homogeneous asymmetric hydrogenation of unprotected N-H ketoimines 3a-3v using Ir-(S,S)-f-binaphane as catalyst provides chiral amines 4a-4v in 90-95% yield with enantioselectivities up to 95% ee.
authors: Department of Chemistry, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854-8066, USA.
authors: Guohua
authors: G
authors: Hou
authors: Francis
authors: F
authors: Gosselin
authors: Wei
authors: W
authors: Li
authors: J Christopher
authors: JC
authors: McWilliams
authors: Yongkui
authors: Y
authors: Sun
authors: Mark
authors: M
authors: Weisel
authors: Paul D
authors: PD
authors: O'Shea
authors: Cheng-yi
authors: CY
authors: Chen
authors: Ian W
authors: IW
authors: Davies
authors: Xumu
authors: X
authors: Zhang
mesh_terms: D006865:Hydrogenation; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007097:Imines