Sensorineural hearing loss in patients with cystic fibrosis.
OBJECTIVE
To determine the prevalence of sensorineural hearing loss (SNHL) in cystic fibrosis (CF) patients and its relationship to antibiotic use.


METHODS
Case series with chart review.


METHODS
Tertiary care pediatric hospital.


METHODS
We reviewed the medical records of CF patients seen in our children's hospital between March 1994 and December 2007. Data collected included patient demographics, audiograms, tympanograms, genotype, and use of potentially ototoxic antibiotics.


RESULTS
Seven of 50 (14%) patients had SNHL. Three percent of patients who received <or=10 courses of intravenous aminoglycosides had SNHL versus 43 percent of those who received >10 courses (P<0.01). No patients who received five or fewer courses of nasal irrigation with aminoglycosides had SNHL versus 23 percent of those who received more than five courses (P<0.05). Nine percent of patients who received five or fewer courses of macrolides had SNHL versus 60 percent of those who received more than five courses (P=0.079).


CONCLUSIONS
CF patients receiving aminoglycosides are at high risk for developing SNHL.
Cheng
Alan G
AG
Department of Otolaryngology and Communication Enhancement, Children's Hospital Boston, and Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA. aglcheng@stanford.edu
Johnston
Patrick R
PR
Luz
Jennifer
J
Uluer
Ahmet
A
Fligor
Brian
B
Licameli
Greg R
GR
Kenna
Margaret A
MA
Jones
Dwight T
DT
D000293:Adolescent; D000328:Adult; D000617:Aminoglycosides / Q000008:administration & dosage / Q000009:adverse effects*; D001299:Audiometry; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D016013:Likelihood Functions; D016015:Logistic Models; D008297:Male
D000617:Aminoglycosides