Are current recommendations to diagnose orthostatic hypotension in Parkinson's disease satisfactory?
We interviewed 50 Parkinson's disease (PD) patients using a questionnaire to verify the reliability of orthostatic symptoms in warning the presence of orthostatic hypotension (OH). OH is defined as 20 mm Hg systolic or 10 mm Hg diastolic BP fall within 3 min of tilting or standing but if this fall occurs after 3 min we called it 'late OH' (L-OH). We compared if OH in Parkinson's disease (PD) was more frequent after head-up tilt or on standing and if the period of postural challenge matters in detecting OH. Twenty-one (42%) patients had OH that occurred twice more often after tilting (n = 20) than on standing (n = 10). OH occurred within 3 min of tilting in 9 patients (18%) and appeared beyond the currently recommended 3 min in 11 patients (55%) (L-OH). Ten of the 20 patients developing OH on tilting were symptomatic. The 10 patients who had OH on standing were asymptomatic. Reporting of symptoms was independent of age or severity of BP fall. Most (90%) patients reporting orthostatic symptoms on standing had OH on tilting for 3 min. Orthostatic symptoms in PD have a high specificity but low sensitivity in predicting OH. In Parkinson's disease OH occurs often after tilting than on standing and is delayed (after 3 min). As OH in PD is often asymptomatic and delayed it could contribute to falls and increase morbidity. We suggest routine evaluation of OH in PD by tilting them longer than the recommended 3 minutes to detect delayed OH.
Jamnadas-Khoda
Jenny
J
School of Health and Related Research, Sheffield University, Sheffield, United Kingdom.
Koshy
Suma
S
Mathias
Christopher J
CJ
Muthane
Uday B
UB
Ragothaman
Mona
M
Dodaballapur
Subbakrishna K
SK
D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000175:diagnosis* / Q000209:etiology*; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D004856:Postural Balance / Q000502:physiology; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D018667:Tilt-Table Test / Q000379:methods; D013997:Time Factors
D000978:Antiparkinson Agents; D007980:Levodopa