title: Usefulness of immature platelet fraction for the clinical evaluation of myelodysplastic syndromes.
abstract: Ratios of young platelets or reticulated platelets can be routinely obtained as an immature platelet fraction (IPF) with the XE-2100 automated hematology analyzer (Sysmex, Kobe, Japan). We combined IPF analysis of 31 patients with myelodysplastic syndrome (MDS) with a complete blood count, a bone marrow examination, and a chromosome analysis. The patients with >40 x 10(9)/L platelets were classified as group A, and those with > or =40 x 10(9)/L were placed in group B. The 2 groups were subclassified as A1 or B1 for patients with an IPF of <10% and as A2 or B2 for those with an IPF > or =10%. Categories A1, A2, B1, and B2 comprised 12 patients, 6 patients, 7 patients, and 6 patients, respectively. Patients with a relatively high IPF (>10%) (category A2 or B2) showed distinctive characteristics. Group B2 showed a higher frequency of chromosomal abnormalities than B1 (P = .029), and group A2 tended to show a higher incidence of clinical improvement than A1 (P = .08). IPF determination may be clinically useful for the assessment of prognosis for MDS patients.
authors: Faculty of Pharmacological Science, Himeji Dokkyo University, Himeji, Japan. ksaigo@himeji-du.ac.jp
authors: Katsuyasu
authors: K
authors: Saigo
authors: Mariko
authors: M
authors: Takenokuchi
authors: Junko
authors: J
authors: Imai
authors: Keiko
authors: K
authors: Numata
authors: Setsuki
authors: S
authors: Isono
authors: Masako
authors: M
authors: Zenibayashi
authors: Hiroaki
authors: H
authors: Tanioka
authors: Toyo
authors: T
authors: Yoshioka
authors: Akihiko
authors: A
authors: Nishizawa
authors: Masafumi
authors: M
authors: Takada
authors: Tsutomu
authors: T
authors: Nomura
authors: Yoshitsugu
authors: Y
authors: Kubota
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count; D001792:Blood Platelets / Q000473:pathology*; D001856:Bone Marrow Examination; D002869:Chromosome Aberrations; D019411:Clinical Laboratory Techniques; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D010976:Platelet Count; D011379:Prognosis; D055815:Young Adult