title: [Relationship of adiponectin and visfatin with fetus intrauterine growth].
abstract: OBJECTIVE
  To explore the correlation between adipocyte factors (adiponectin and visfatin) and fetus intrauterine growth.
  
  
  METHODS
  Enzyme immunoassay was used to measure the adiponectin and visfatin levels in maternal and umbilical serum from 14 women with fetal growth restriction (FGR group), 14 women with macrosomia (macrosomia group) and 14 normal pregnant women (control group). The correlations of cord serum adiponectin and visfatin with maternal serum adiponectin and visfatin were analyzed.
  
  
  RESULTS
  (1) Serum visfatin levels in FGR mothers [(41.4 +/- 5.5)] microg/L were significantly higher than that in control women [(34.7 +/- 4.9) microg/L] and macrosomia mothers [(37.3 +/- 4.4) microg/L; P < 0.01, P < 0.05]. Serum adiponectin levels in macrosomia mothers [(4.1 +/- 1.3) mg/L] were significantly lower than that in control women [(6.6 +/- 1.5) mg/L] and FGR mothers [(6.4 +/- 1.3) mg/L; P < 0.01]. (2) Serum visfatin levels in FGR babies [(58.1 +/- 7.6) microg/L] were significantly increased than that in control newborns [(42.6 +/- 7.8) microg/L] and macrosomia babies [(48.5 +/- 9.1) microg/L; P < 0.01, P < 0.05]. Serum adiponectin levels in macrosomia babies [(6.5 +/- 1.3) mg/L] were significantly decreased than that in control newborns [(7.7 +/- 1.5) mg/L] and FGR babies [(7.7 +/- 1.0) mg/L; P < 0.05, P < 0.05]. (3) Maternal serum visfatin levels were positively correlated with umbilical serum visfatin levels (r = 0.720, P < 0.01). Umbilical serum adiponectin levels were higher than that in maternal serum, but there were no relationship between them (r = 0.301, P > 0.05).
  
  
  CONCLUSIONS
  The changes of visfatin and adiponectin levels may be related to the occurrence of FGR and fetal macrosomia.
authors: Department of Obstetrics and Gynecology, General Hospital of Beijing Military Command, Beijing 100700, China. tangling0819@yahoo.com.cn
authors: Li-xin
authors: LX
authors: Shang
authors: Qing-ling
authors: QL
authors: Tang
authors: Jing
authors: J
authors: Wang
authors: Fang
authors: F
authors: Zhang
authors: Nan
authors: N
authors: Wu
authors: Shu-he
authors: SH
authors: Wang
authors: Ping
authors: P
authors: Li
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D047109:Fetal Development; D005317:Fetal Growth Retardation / Q000097:blood* / Q000503:physiopathology; D005320:Fetal Macrosomia / Q000097:blood / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D054409:Nicotinamide Phosphoribosyltransferase