[Using of chromatographical methods to study stability, pharmacokinetics and metabolism of propofol (review)].
Propofol (somnopol, diprivan) 2,6-diisoprophilphenol is a preparation of short-term, intravenous narcosis used for local and general anaesthesia through single injection or permanent infusion with the speed of 4-12 mg/kg in an hour. In this study we tried to summarize the experience of using of chromatographical methods (gas chromatography-GCH0, high performance liquid chromatography (HPLC), thin layer chromatography (TLCH) and combination of mass-spectrometry with GCH (GCH-MC) and HPLC (HPL-MC) to study stability, pharmacokinetics and metabolism of propofol. A labour-intensive and important work have been carried out to obtain information about propofol.
Adeishvili-Anguladze
L V
LV
Makharadze
R V
RV
Kurtsikidze
M Sh
MSh
Abuladze
N B
NB
Gabuniia
K U
KU
D018686:Anesthetics, Intravenous / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics*; D000818:Animals; D002845:Chromatography / Q000379:methods; D006801:Humans; D015742:Propofol / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics*; D051381:Rats
D018686:Anesthetics, Intravenous; D015742:Propofol