title: Polymorphisms in the Renin-Angiotensin system and outcome of very-low-birthweight infants.
abstract: BACKGROUND
  The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity.
  
  
  OBJECTIVE
  To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants.
  
  
  METHODS
  Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively.
  
  
  RESULTS
  There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus.
  
  
  CONCLUSIONS
  Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.
authors: Department of Pediatrics, University of Lubeck, Lubeck, Germany. spiegler@paedia.ukl.mu-luebeck.de
authors: J
authors: J
authors: Spiegler
authors: A
authors: A
authors: Gilhaus
authors: I R
authors: IR
authors: Konig
authors: E
authors: E
authors: Kattner
authors: M
authors: M
authors: Vochem
authors: H
authors: H
authors: Kuster
authors: J
authors: J
authors: Moller
authors: D
authors: D
authors: Muller
authors: A
authors: A
authors: Kribs
authors: H
authors: H
authors: Segerer
authors: C
authors: C
authors: Wieg
authors: W
authors: W
authors: Nikischin
authors: A
authors: A
authors: von der Wense
authors: C
authors: C
authors: Gebauer
authors: E
authors: E
authors: Herting
authors: W
authors: W
authors: Gopel
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000235:genetics*; D019102:Infant, Very Low Birth Weight / Q000502:physiology*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012084:Renin-Angiotensin System / Q000235:genetics*