SIRT1: a novel target to prevent atherosclerosis.
Atherosclerosis is a chronic immuno-inflammatory disease associated with blood lipids disorder. Many studies have demonstrated that caloric restriction (CR) can prevent atherosclerosis and extend lifespan. Sir2 protein, mammal's SIRT1, has been reported to at least partly contribute to the protective effect of CR. Hence, we hypothesize that SIRT1 is a key regulator in the pathogenesis of atherosclerosis and that upregulation of SIRT1 in endothelial cells may mimic CR's beneficial effect on vascular health. The recent studies have demonstrated that endothelial SIRT1 is an anti-atherosclerosis factor and the possible mechanism may be related to inhibit oxidized low-density lipoprotein (oxLDL)-induced apoptosis, upregulate endothelial nitric oxide synthase (eNOS) expression, and improve endothelium relaxation function. We infer that SIRT1 may be a novel target for atherosclerosis prevention and treatment.
Yu
Wei
W
Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Fu
Yu-Cai
YC
Chen
Chun-Juan
CJ
Wang
Xin
X
Wang
Wei
W
D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000517:prevention & control*; D031204:Caloric Restriction; D042783:Endothelial Cells / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D056564:Sirtuin 1 / Q000378:metabolism*
D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D052250:Nitric Oxide Synthase Type III; D056564:Sirtuin 1