Fullerene nanomaterials inhibit phorbol myristate acetate-induced inflammation.
Inflammation is a natural biological response that occurs when vascular tissues are subjected to harmful stimuli. This process may be beneficial to the host during wound healing and infections but can be detrimental if left unchecked. Oxidative stress, the generation of reactive oxygen species, is thought to be one component of this response. Fullerenes can counteract reactive oxygen species due to their potent antioxidant capabilities. Thus, we hypothesized that these molecules may inhibit inflammation. To test this hypothesis we used an in vivo model of phorbol 12-myristate 13-acetate (PMA)-induced inflammation and examined the effects fullerenes have on mitigating this response. We show that PMA-induced inflammation and oedema is dramatically inhibited when fullerenes are given prior to challenge. Thus, fullerene derivatives may be a novel way to blunt certain inflammatory conditions and facilitate faster recovery of damaged tissue.
Dellinger
Anthony
A
Luna Nanoworks, Danville, VA, USA.
Zhou
Zhiguo
Z
Lenk
Robert
R
MacFarland
Darren
D
Kepley
Christopher L
CL
D000818:Animals; D003877:Dermatitis, Contact / Q000150:complications / Q000473:pathology / Q000517:prevention & control*; D054644:Ear Auricle / Q000187:drug effects / Q000473:pathology; D004487:Edema / Q000209:etiology / Q000473:pathology; D037741:Fullerenes / Q000627:therapeutic use*; D007249:Inflammation / Q000139:chemically induced* / Q000150:complications / Q000473:pathology / Q000517:prevention & control*; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D049329:Nanostructures / Q000627:therapeutic use*; D013755:Tetradecanoylphorbol Acetate / Q000008:administration & dosage / Q000494:pharmacology*
D037741:Fullerenes; D013755:Tetradecanoylphorbol Acetate