title: Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
abstract: To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, , Oxford, United Kingdom.
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mesh_terms: D050154:Adiposity; D000328:Adult; D050218:Body Fat Distribution; D015331:Cohort Studies; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008245:Lysophospholipase / Q000235:genetics*; D008297:Male; D051150:Methionine Sulfoxide Reductases; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D010088:Oxidoreductases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D050656:Transcription Factor AP-2 / Q000235:genetics*; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: C493677:TFAP2B protein, human; D050656:Transcription Factor AP-2; D010088:Oxidoreductases; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase; D008245:Lysophospholipase