Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules.
This review describes the progress that has been made in understanding the PI3-K-PKB-mTOR signalling pathway by using small molecules as pharmacological probes. It briefly covers the structural characteristics, regulation of and downstream effects of several key regulators of PI3-K-PKB-mTOR signalling, then highlights the use of small molecules (by structural type) to selectively modulate specific components of the pathway.
Gunn
Richard M
RM
Department of Chemistry, University College London, London, WC1H 0AJ, UK, richard.gunn05@imperial.ac.uk.
Hailes
Helen C
HC