Major depression and health-related quality of life in Parkinson's disease.
Depression is a common psychiatric condition in Parkinson's disease (PD), yet the burden of depression on health-related quality of life (HRQL) has not been clearly delineated in this patient population.


OBJECTIVE
To evaluate the impact of depression and life stress on HRQL in the Canadian community dwelling population with PD.


METHODS
A total of 259 respondents from the Canadian Community Health Survey (CCHS 1.1) with self-reported PD were interviewed. Measures included Health Utilities Index Mark 3 (HUI3), Composite International Diagnostic Interview Short Form for Major Depression and a single question regarding the amount of stress in their lives most days. Adjusted HUI3 scores were compared according to depression and life stress using ANCOVA models.


RESULTS
Respondents without depression had overall HUI3 scores that were 0.29 units higher than respondents with depression [adjusted mean (95% CI) 0.49 (0.39-0.59) vs. 0.20 (0.03-0.37)]. The difference in overall HUI3 scores between respondents who reported high levels of stress as those who did not was 0.19 [adjusted mean (95% CI) 0.42 (0.29-0.55) vs. 0.23 (0.10-0.36)].


CONCLUSIONS
Substantial impact of depression and life stress, two modifiable factors, on HRQL is seen in PD. HRQL may be improved by clinical management of these nonmotor symptoms in PD.
Jones
C Allyson
CA
School of Public Health, University of Alberta, Edmonton, AB T6G 2G4, Canada. cajones@ualberta.ca
Pohar
Sheri L
SL
Patten
Scott B
SB
D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D000704:Analysis of Variance; D001294:Attitude to Health; D002170:Canada / Q000453:epidemiology; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D007406:Interview, Psychological; D008016:Life Change Events; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000453:epidemiology / Q000523:psychology*; D011159:Population Surveillance; D015995:Prevalence; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D011795:Surveys and Questionnaires