title: Pharmacokinetic studies of levofloxacin after oral administration in healthy and febrile cow calves.
abstract: The present experiment was designed to study the pharmacokinetics of levofloxacin in six healthy cross bred female cow calves (4 to 6 months age) weighing between 40 to 80 kg. Plasma from blood was separated by centrifugation at 10,000 rpm. Quantitative estimation of levofloxacin was done by UV-VIS spectrophotometer at 286 nm. The mean maximum plasma concentration (Cp(max)) of levofloxacin in febrile calves (5.28±0.32 μg/ml) did not differ significantly as compared with healthy calves (4.50±0.22 μg/ml) after single dose (20 mg/kg) oral administration. The mean therapeutic plasma concentration (Cp(ther)) of levofloxacin was maintained for longer period in febrile calves (10 h) as compared to healthy calves ( 8 h). The mean maximum urine concentration (Cu(max)) in febrile (40.86±2.19 μg/ml) also did not differ significantly as compared with healthy calves (39.38±2.43 μg/ml). No significant difference in various pharmacokinetic parameters of plasma was observed in healthy calves ( β=0.23±0.01/h ; t½β=3.00±0.17 h and MRT=4.66±0.14 h ) and febrile calves ( β=0.23±0.01/ h; t½β=3.05±0.16 h and MRT=5.04±0.14 h). The mean value of β, and t½β calculated in urine also did not differ between healthy and febrile calves. However, the value of MRT(3.79±0.07 h) and Cl(B) (1.65±0.09 ml/kg/min) calculated in urine of febrile calves significantly (p<0.05) differ to healthy calves (MRT=3.15±0.03 h;Cl(B)=2.09±0.13 ml/kg/min). Based on kinetic profile levofloxacin may be given orally at the dose rate of 1.49 mg/kg B.W.at 8 h intervals in febrile calves.
authors: Gaunaha, District-Betia, Paschmi Champaran, Bihar, India.
authors: Santosh
authors: S
authors: Kumar
authors: Subodh
authors: S
authors: Kumar
authors: Vijay
authors: V
authors: Kumar
authors: Kaushal K
authors: KK
authors: Singh
authors: Birendra K
authors: BK
authors: Roy
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism*; D005260:Female; D005334:Fever / Q000378:metabolism / Q000662:veterinary*; D064704:Levofloxacin; D015242:Ofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin