Excisional breast biopsy under local anesthesia: stress-related neuroendocrine, metabolic and immune reactions during the procedure.
OBJECTIVE
The aim of this study was to evaluate three axes: the sympathetic system (adrenaline and noradrenaline), surgical stress-related endocrine factors (prolactin, cortisol, insulin, glucose and growth hormone) and inflammatory cytokines (IL-1alpha, IL-1beta and IL-6) during excisional breast biopsy under local anesthesia (EBBLA).


METHODS
On 14 women undergoing EBBLA, all the aforementioned molecules were measured in peripheral venous blood samples prior (baseline), during (at 10 and 30 minutes), at the end of EBBLA (46+/-9 minutes) and one hour after its end.


RESULTS
Serum growth hormone glucose and cortisol were found elevated at the 10th and 30th minute and at the end of EBBLA. Serum prolactin increased only at the 30th minute. Of notice, none of the measured parameters was found elevated one hour after the end of biopsy. Concerning adrenaline, noradrenaline and interleukins, no significant changes were documented.


CONCLUSIONS
During EBBLA, significant stress-related endocrine events arise. However, no significant sympathetic / cytokine triggering was noted.
Zografos
George C
GC
Breast Unit, First Department of Propaedeutic Surgery, Hippokratio Hospital, School of Medicine, Associate Professor of Surgery, University of Athens, 101, Vas Sofias Ave, Ampelokipi, Athens 11521, Greece. gzografo@med.uoa.gr
Zagouri
Flora
F
Sergentanis
Theodoros N
TN
Giannakopoulou
Georgia
G
Provatopoulou
Xeni
X
Kalogera
Eleni
E
Papadimitriou
Christos
C
Filippakis
George
G
Sagkriotis
Alexandros
A
Bramis
John
J
Gounaris
Antonia
A
D000328:Adult; D000772:Anesthesia, Local; D001706:Biopsy / Q000523:psychology*; D001941:Breast Diseases / Q000473:pathology* / Q000523:psychology; D005260:Female; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007107:Immune System / Q000276:immunology / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D053582:Interleukin-1alpha / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000276:immunology / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D013315:Stress, Psychological / Q000276:immunology / Q000378:metabolism*
D007328:Insulin; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D015850:Interleukin-6; D019382:Human Growth Hormone; D011388:Prolactin; D006854:Hydrocortisone