Human telomere length correlates to the size of the associated chromosome arm.
The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from (http://www.ncbi.nlm.nih.gov/projects/mapview/).
Wise
Jasen L
JL
Department of Pathology, West Virginia University, Morgantown, WV, USA. jasenwise@gmail.com
Crout
Richard J
RJ
McNeil
Daniel W
DW
Weyant
Robert J
RJ
Marazita
Mary L
ML
Wenger
Sharon L
SL
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002875:Chromosomes / Q000502:physiology / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D012737:Sex Factors; D016615:Telomere / Q000502:physiology / Q000648:ultrastructure*