From parasite genomes to one healthy world: Are we having fun yet?
In 1990, the Human Genome Sequencing Project was established. This laid the ground work for an explosion of sequence data that has since followed. As a result of this effort, the first complete genome of an animal, Caenorhabditis elegans was published in 1998. The sequence of Drosophila melanogaster was made available in March, 2000 and in the following year, working drafts of the human genome were generated with the completed sequence (92%) being released in 2003. Recent advancements and next-generation technologies have made sequencing common place and have infiltrated every aspect of biological research, including parasitology. To date, sequencing of 32 apicomplexa and 24 nematode genomes are either in progress or near completion, and over 600k nematode EST and 200k apicomplexa EST submissions fill the databases. However, the winds have shifted and efforts are now refocusing on how best to store, mine and apply these data to problem solving. Herein we tend not to summarize existing X-omics datasets or present new technological advances that promise future benefits. Rather, the information to follow condenses up-to-date-applications of existing technologies to problem solving as it relates to parasite research. Advancements in non-parasite systems are also presented with the proviso that applications to parasite research are in the making.
Zarlenga
Dante S
DS
USDA, ARS, ANRI Animal Parasitic Diseases Laboratory, Beltsville, MD 20705, USA. Dante.Zarlenga@ars.usda.gov
Gasbarre
Louis C
LC
D000818:Animals; D049751:Genome, Helminth; D018503:Genome, Protozoan; D023281:Genomics / Q000379:methods; D006790:Host-Parasite Interactions / Q000235:genetics*; D010273:Parasitic Diseases, Animal / Q000469:parasitology*