Dengue virus type 3 in Brazil: a phylogenetic perspective.
Circulation of a new dengue virus (DENV)-3 genotype was recently described in Brazil and Colombia, but the precise classification of this genotype has been controversial. Here we perform phylogenetic and nucleotide-distance analyses of the envelope gene, which support the subdivision of DENV-3 strains into five distinct genotypes (GI to GV) and confirm the classification of the new South American genotype as GV. The extremely low genetic distances between Brazilian GV strains and the prototype Philippines/L11423 GV strain isolated in 1956 raise important questions regarding the origin of GV in South America.
Araújo
Josélio Maria Galvão de
JM
Laboratório de Flavivirus, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil. joselio@ioc.fiocruz.br
Bello
Gonzalo
G
Schatzmayr
Hermann Gonçalves
HG
Santos
Flávia Barreto dos
FB
Nogueira
Rita Maria Ribeiro
RM
D001938:Brazil; D003716:Dengue Virus / Q000145:classification / Q000235:genetics*; D005838:Genotype; D006801:Humans; D009711:Nucleotides / Q000235:genetics; D010802:Phylogeny; D014759:Viral Envelope Proteins / Q000235:genetics
D009711:Nucleotides; D014759:Viral Envelope Proteins