Lack of association with rheumatoid arthritis of selected polymorphisms in 4 candidate genes: CFH, CD209, eotaxin-3, and MHC2TA.
OBJECTIVE
To investigate associations with rheumatoid arthritis (RA) of single-nucleotide polymorphisms (SNP) in 4 candidate genes, complement factor H (CFH), CD209 or DC-SIGN, eotaxin-3, and the MHC class II Transactivator (MHC2TA) genes. These SNP have been reported as important for RA (eotaxin-3 and MHC2TA) or for other immune-mediated diseases (CFH and CD209).


METHODS
Genotypes for the 7 selected SNP were obtained from 1587 patients with RA and 1570 controls of Spanish ancestry. Analyses were carried out after stratification for sex, erosions, rheumatoid factor, shared epitope, anti-cyclic citrullinated peptide antibodies, and the R620W PTPN22 SNP.


RESULTS
None of the comparisons between patients with RA and controls or between the different strata of patients according to disease features was significant.


CONCLUSIONS
None of the SNP in CFH and CD209 showed evidence of association with RA. We did not replicate the association of eotaxin-3 with RA described in Koreans, or that of the MHC2T SNP.
Dieguez-Gonzalez
Rebeca
R
Laboratorio de Investigacion 10, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
Akar
Servet
S
Calaza
Manuel
M
Gonzalez-Alvaro
Isidoro
I
Fernandez-Gutierrez
Benjamin
B
Lamas
Jose Ramon
JR
de la Serna
Arturo R
AR
Caliz
Rafael
R
Blanco
Francisco J
FJ
Pascual-Salcedo
Dora
D
Velloso
Maria Luisa
ML
Perez-Pampin
Eva
E
Pablos
Jose Luis
JL
Navarro
Federico
F
Narvaez
Javier
J
Lopez-Longo
Francisco Javier
FJ
Herrero-Beaumont
Gabriel
G
Gomez-Reino
Juan J
JJ
Gonzalez
Antonio
A
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics*; D000075906:Chemokine CCL26; D019742:Chemokines, CC / Q000235:genetics*; D017242:Complement Factor H / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics*; D013030:Spain; D015534:Trans-Activators / Q000235:genetics*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D000075906:Chemokine CCL26; D019742:Chemokines, CC; D017242:Complement Factor H; D037181:Lectins, C-Type; D009687:Nuclear Proteins; D011956:Receptors, Cell Surface; D015534:Trans-Activators; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C120429:CCL26 protein, human; C493495:CFH protein, human; C083728:MHC class II transactivator protein