title: Adjustment Disorder: epidemiology, diagnosis and treatment.
abstract: BACKGROUND
  Adjustment Disorder is a condition strongly tied to acute and chronic stress. Despite clinical suggestion of a large prevalence in the general population and the high frequency of its diagnosis in the clinical settings, there has been relatively little research reported and, consequently, very few hints about its treatments.
  
  
  METHODS
  the authors gathered old and current information on the epidemiology, clinical features, comorbidity, treatment and outcome of adjustment disorder by a systematic review of essays published on PUBMED.
  
  
  RESULTS
  After a first glance at its historical definition and its definition in the DSM and ICD systems, the problem of distinguishing AD from other mood and anxiety disorders, the difficulty in the definition of stress and the implied concept of 'vulnerability' are considered. Comorbidity of AD with other conditions, and outcome of AD are then analyzed. This review also highlights recent data about trends in the use of antidepressant drugs, evidence on their efficacy and the use of psychotherapies.
  
  
  CONCLUSIONS
  AD is a very common diagnosis in clinical practice, but we still lack data about its rightful clinical entity. This may be caused by a difficulty in facing, with a purely descriptive methods, a "pathogenic label", based on a stressful event, for which a subjective impact has to be considered. We lack efficacy surveys concerning treatment. The use of psychotropic drugs such as antidepressants, in AD with anxious or depressed mood is not properly supported and should be avoided, while the usefulness of psychotherapies is more solidly supported by clinical evidence. To better determine the correct course of therapy, randomized-controlled trials, even for the combined use of drugs and psychotherapies, are needed vitally, especially for the resistant forms of AD.
authors: Centro per la Ricerca e la Terapia in Salute Mentale, Department of Public Health, University of Cagliari, Italy. mgcarta@tiscali.it.
authors: Mauro Giovanni
authors: MG
authors: Carta
authors: Matteo
authors: M
authors: Balestrieri
authors: Andrea
authors: A
authors: Murru
authors: Maria Carolina
authors: MC
authors: Hardoy