[Arterial hypertension in patients with chronic obstructive pulmonary disease in combination with coronary artery disease].
OBJECTIVE
To study clinicofunctional features of arterial hypertension (AH) in patients with chronic obstructive pulmonary disease (COPD) including COPD patients with coronary artery disease (CAD); 24-h profile of blood pressure (BP) and changes in intracardiac hemodynamics; to compare the disturbances detected.


METHODS
1256 patients were divided into 3 groups, 395 AH patients with COPD entered group 1; 509 AH patients with COPD and CAD, angina of effort--group 2, 352 AH patients with CAD--group 3.


RESULTS
Most patients with comorbid diseases have 24-h BP profile of non dipper and night picker types in the presence of high heart rate explained by COPD effect on AH course. Lower BP in group 2 patients results from progressive maladaptive heart remodeling, attenuation of the systolic function, increasing number of patients with a restrictive type of transmitral blood flow.


CONCLUSIONS
COPD patients with AH have more severe and frequent changes in target organs, poor prognosis as these diseases aggravate each other.
Klester
E B
EB
Shoĭkhet
Ia N
IaN
D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D003324:Coronary Artery Disease / Q000150:complications* / Q000503:physiopathology; D018450:Disease Progression; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000503:physiopathology; D016276:Ventricular Function / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology