[Dynamic assessment of bone tissue osteocytic remodeling using a noninvasive method].
Projectional bone mineral density (PBMD) in the proximal region of both femoral bones, the distal part of the forearm bones on both sides and in the lumbar vertebrae was studied with the method of dual energy roentgen absorption (DEXA) in two male volunteers at the age of 40 and 60 years on a daily basis during one month. On the basis of the results of the estimation of each area of interest (AI) M(av), oscillation range (4(sigma)) and the greatest difference were calculated. In addition to it, a statistic mathematic modeling was conducted through smoothing out the dynamic rows of the results achieved for each AI. It was found out that the average oscillation range exceeded 9% of the average index value, which is thrice as much as the method reproducibility error. This kind of investigation in the process of treatment allows monitoring its efficiency taking into consideration both mechanisms (osteoblastic-osteoclastic remodeling and osteocytic remodeling) as well as estimating the toxic effects of medical agents on bone cells. As a result of statistic mathematic modeling, cercaseptane periodicity of PBMD changes with the average period of 5.5 days was found. The authors see the cause of these short-term changes in osteocytic remodeling and suggest to use a dynamic successive PBMD measurements during 7-10 days as a way of non-invasive monitoring of osteocyte resorption-synthetic activity in AI.
Avrunin
A S
AS
Tikhilov
R M
RM
Shubniakov
I I
II
D015502:Absorptiometry, Photon; D000328:Adult; D050280:Arm Bones / Q000000981:diagnostic imaging / Q000502:physiology*; D015519:Bone Density / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology*; D005269:Femur / Q000000981:diagnostic imaging / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results