title: Cinnamic aldehyde derived probes for the active site labelling of pathogenesis associated enzymes.
abstract: Michael acceptor based natural product derived probes are selective and sensitive chemical tools for the identification and characterization of pathologically relevant enzymes in MRSA.
authors: Center for Integrated Protein Science Munich CIPSM, Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany.
authors: Maximilian
authors: M
authors: Pitscheider
authors: Stephan A
authors: SA
authors: Sieber
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D001419:Bacteria / Q000201:enzymology* / Q000378:metabolism; D020134:Catalytic Domain; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004798:Enzymes / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D020543:Proteome / Q000378:metabolism; D013194:Staining and Labeling
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes; D020543:Proteome; D000171:Acrolein; D017027:Protein Tyrosine Phosphatases; C012843:cinnamaldehyde