A large-scale retrospective study of closing-in behavior in Alzheimer's disease.
The frequency and characteristics of closing-in behavior (CIB) were examined in 797 patients with Alzheimer's disease (AD), 132 of whom were followed up longitudinally. The frequency of CIB increased with the complexity of the graphic copying task and with the severity of Alzheimer's disease. Regression analyses suggested that attentional deficits are critical factors for the appearance of CIB, but that visuospatial impairments also play an important role in the emergence of severe forms of CIB.
Ambron
Elisabetta
E
Department of Psychology, Human Cognitive Neuroscience, University of Edinburgh, Edinburgh, United Kingdom.
McIntosh
Robert D
RD
Allaria
Francesca
F
Della Sala
Sergio
S
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000523:psychology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007100:Imitative Behavior / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual; D010468:Perceptual Disorders / Q000175:diagnosis* / Q000209:etiology*; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology*; D012189:Retrospective Studies