What are the roles of microRNAs at the mammalian synapse?
The modification of neuronal connections in response to stimuli is believed to be the basis of long-term memory formation. It is currently accepted that local protein synthesis critically contributes to site-restricted modulation of individual synapses. Here, we summarize recent evidence implicating miRNAs in this process, leading to altered dendrite morphogenesis and synaptic plasticity. Second, we discuss findings in non-neuronal systems about how RNA-binding proteins can modulate miRNA-mRNA interactions, and how these mechanisms might apply to neurons. Finally, we review recent findings that P-bodies may be important sites for miRNA action at the synapse.
Konecna
Anetta
A
Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria.
Heraud
Jacki E
JE
Schoderboeck
Lucia
L
Raposo
Alexandre A S F
AA
Kiebler
Michael A
MA
D000818:Animals; D003712:Dendrites / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000033:anatomy & histology* / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology*; D008954:Models, Biological; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D035683:MicroRNAs