Frontotemporal dementia and motor neurone disease: overlapping clinic-pathological disorders.
Advances in genetics and pathology have supported the idea of a continuum between frontotemporal dementia (FTD) and motor neurone disease (MND), which is strengthened by the discovery of the trans-activating responsive (Tar) sequence DNA binding protein (TDP-43) as a key component in the underlying pathology of FTD, FTD-MND and sporadic and familial MND patients. MND is a multisystem disorder associated with cognitive and behavioural changes which in some instances reaches the criteria for FTD, while a proportion of patients with FTD develop frank MND. We review the overlap between FTD and MND, emphasizing areas of controversy and uncertainty.
Lillo
Patricia
P
Prince of Wales Medical Research Institute, Barker St, Randwick, New South Wales 2031, Australia.
Hodges
John R
JR
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D003704:Dementia / Q000235:genetics / Q000473:pathology* / Q000523:psychology; D006801:Humans; D016472:Motor Neuron Disease / Q000235:genetics / Q000473:pathology* / Q000523:psychology
D004268:DNA-Binding Proteins