title: A simple and convenient copper-catalyzed tandem synthesis of quinoline-2-carboxylates at room temperature.
abstract: We developed a simple and convenient copper-catalyzed method for the synthesis of quinoline-2-carboxylate derivatives through sequential intermolecular addition of alkynes onto imines and subsequent intramolecular ring closure by arylation. The efficiency of this system allowed the reactions to be carried out at room temperature.
authors: Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
authors: He
authors: H
authors: Huang
authors: Hualiang
authors: H
authors: Jiang
authors: Kaixian
authors: K
authors: Chen
authors: Hong
authors: H
authors: Liu
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D000480:Alkynes; D007097:Imines; D009942:Organometallic Compounds; D011804:Quinolines; C059924:quinoline-4-carboxylic acid; D003300:Copper