[Clinicopathological analysis and differential diagnosis of primary peritoneal adenocarcinoma].
OBJECTIVE
To investigate the clinicopathological characteristics and differential diagnosis of primary peritoneal adenocarcinoma.


METHODS
The clinico-pathological data of 8 patients with primary peritoneal adenocarcinoma, all female, aged 55.7 (45 - 69), were analyzed retrospectively. Immunohistochemistry was used to detect the expression of pan-cytokine, cytokine (CK) 7, CK20, CA125, CEA, epithelial membrane antigen (EMA), vimentin, calretinin, and P63 in the specimens of tumor obtained during tumor reduction surgery. Microscopy was conducted for pathological examination.


RESULTS
The common clinical symptoms of these 8 patients included abdominal distention and ascites. Pre-operationally, 6 cases were diagnosed as with ovarian cancer, I case as with malignant mesothelioma, and I as with peritoneal carcinoma. The misdiagnosis rate was 87.5%. Post-operational pathological examination showed 7 cases of serous papillary adenocarcinoma and one case of mucinous adenocarcinoma. Immunohistochemistry showed the positive rates of the different biological markers as follows: pan-CK (8/8), CK7 (8/8), CK20 (1/8), CA125 (7/8), CEA (7/8), EMA (8/8), vimentin (1/8), calretinin (1/8), and P53 (8/8).


CONCLUSIONS
A rare malignant tumor arising from the secondary Müllerian system, primary peritoneal adenocarcinoma shares similar histopathological characters with ovary carcinoma, so is easy to be misdiagnosed. Immunohistochemical staining is helpful to the differential diagnosis.
Gong
Hui-Lin
HL
Department of Pathology, First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, China. gonghuilin1214@126.com
Wang
Chun-Bao
CB
Zhang
Guan-Jun
GJ
Li
Chun-Fang
CF
Yang
Xin-Yuan
XY
Hou
Hui-Lian
HL
Zhang
Xue-Bin
XB
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D018394:CA-125 Antigen / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies
D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen