A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug.
Isotretinoin is a known human teratogen that can cause multiple malformations. At present, women who conceive one cycle after discontinuing isotretinoin are told that their teratogenic risk is not higher than baseline. We present a case of both-ear malformation in a newborn whose mother had taken isotretinoin for 2 years until one month prior to the time when she became pregnant. We suggest that further studies of pharmacokinetics and malformation of isotretinoin are needed.
Lee
Soon Min
SM
Department of Pediatrics, Yonsei University College of Medicine, 250 Seongsan-ro, Seodaemun-gu,Seoul, Korea.
Kim
He Min
HM
Lee
Jun Seok
JS
Yoon
Choon Sik
CS
Park
Min Soo
MS
Park
Kook In
KI
Namgung
Ran
R
Lee
Chul
C
D000014:Abnormalities, Drug-Induced / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015474:Isotretinoin / Q000009:adverse effects*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D015474:Isotretinoin