title: [Gastroesophageal reflux disease: pathogenetic basis of differentiated tactics of treatment].
abstract: The article contains information about severe side effects of long-term acid suppression with non-select proton pump inhibitors (PPI) treatment of gastroesophageal reflux disease (GERD). As far as concern patients with heartborn without esophagitis (non-erosive GERD) using PPI doesn't correspond the pathogenesis and hardly has any advantages. Therapy with gastric acidity inhibitors increases risk of acute gastroenteritis and community-acquired pneumonia. Quality of life is rising and symptoms of gastro-esophageal reflux are getting away thanks to topical harmless treatment GERD without severe esophagitis Pepsan-R.
authors: E I
authors: EI
authors: Tkachenko
authors: Iu P
authors: IuP
authors: Uspenskiĭ
authors: A E
authors: AE
authors: Karateev
authors: I G
authors: IG
authors: Bakulin
authors: I G
authors: IG
authors: Pakhomova
mesh_terms: D004305:Dose-Response Relationship, Drug; D005265:Femoral Neck Fractures / Q000453:epidemiology / Q000209:etiology; D005744:Gastric Acid / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D011014:Pneumonia / Q000453:epidemiology / Q000209:etiology; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011788:Quality of Life; D013997:Time Factors
chemical_list: D005765:Gastrointestinal Agents; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors