[Study on the optimal extracion craft of Xiaochuang gel by central composite design-response surface methodology].
OBJECTIVE
To optimize the extraction craft of Xiaochuang gel by central composite design-response surface methodology.


METHODS
The main influential factors of extraction effect included the quantity of ethanol, the concentration of ethanol and the extraction time. The conditions of the extraction were evaluated by the yield of the extracts and the total content of rheum emodin and chrysophanol. The optimal extraction craft of Xiaochuang gel was chosen by central composite design-response surface methodology.


RESULTS
The optimal conditions were extracting two times, two hours each time with ten volume multiples of 60% ethanol.


CONCLUSIONS
It is simple, convenient and highly predictive to optimize the extraction craft of Xiaochuang gel by central composite design-response surface methodology.
Chen
Wei-Wei
WW
Guangxi Traditional Chinese Medical University, Nanning 530001, China. weiwei690413@eyou.com
Xu
Dong-Ying
DY
Deng
Chao-Cheng
CC
Feng
Kan
K
Zhu
Xiao-Yong
XY
D000880:Anthraquinones / Q000032:analysis*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D004642:Emodin / Q000032:analysis; D000431:Ethanol / Q000008:administration & dosage / Q000737:chemistry; D005782:Gels; D010946:Plants, Medicinal / Q000737:chemistry*; D012250:Rheum / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors
D000880:Anthraquinones; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005782:Gels; D012997:Solvents; D000431:Ethanol; D004642:Emodin