title: Methotrexate-induced Hodgkin disease in a patient with systemic lupus erythematosus.
abstract: Methotrexate sodium use in the management of various immunologic disorders has increased--as have the number of reported adverse effects associated with this therapy. While methotrexate has helped combat various autoimmune and cancerous disorders, the paradoxical risk of causing an often fatal malignancy may still occur as a result of the drug's effect on suppressing immune function. We present a case of methotrexate-induced Hodgkin disease in a 48-year-old man with a history of systemic lupus erythematosus (SLE). Discontinuation of methotrexate facilitated Hodgkin disease reversal. In addition, we review other lymphoproliferative hematologic malignancies caused by methotrexate.
authors: Lake Erie College of Osteopathic Medicine School of Pharmacy, Erie, PA 16509-1025, USA. ssliesoraitis@lecom.edu
authors: Sarunas
authors: S
authors: Sliesoraitis
authors: Rizwan
authors: R
authors: Khan
authors: Jan
authors: J
authors: Rothman
mesh_terms: D006689:Hodgkin Disease / Q000139:chemically induced* / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate