[Laparoscopic surgery and adjuvant therapy for colon cancer].
At present, about 10% of all oncological procedures in the colon are carried out laparoscopically. Acceptance is increasing. After successful R0 resection, the rule for stage III patients is: adjuvant therapy is indicated regardless of age. Regimens containing oxaliplatin should be used. If there are contraindications for oxaliplatin, then fluoropyrimidine monotherapy is indicated, with oral fluoropyrimidines (capecitabine) being given precedence over infusional schemes. The use of 5-FU bolus regimens is regarded as obsolete. For stage II, the following applies: If an adjuvant chemotherapy is planned in these patients on the basis of the QUASAR data, then fluoropyrimidine monotherapy (e. g. capecitabine) can be given. Since patients whose tumours show a high frequency of microsatellite instability (MSI) do not benefit from a fluoropyrimidine monotherapy, the MSI status should be determined before choosing therapy.
Kubicka
Stefan
S
Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Deutschland.
Geissler
Michael
M
Bruch
Hans-Peter
HP
Trarbach
Tanja
T
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant / Q000639:trends; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D016099:Endoscopy, Gastrointestinal / Q000639:trends*; D006801:Humans; D010535:Laparoscopy / Q000639:trends*
D000964:Antimetabolites, Antineoplastic