Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis.
Nineteen adults with pulmonary tuberculosis received linezolid (600 mg) once or twice daily in an early bactericidal activity trial. A one-compartment population model produced median values for the absorption rate constant, volume of distribution, and elimination rate constant of 1.5 h(-1), 29.6 liters, and 0.25 h(-1) (once daily) and 2.7 h(-1), 32.1 liters, and 0.15 h(-1) (twice daily). Linezolid administered twice daily produced higher values for free drug area under the concentration-time curve (AUC)/MIC and time above MIC. Both regimens achieved free AUC/MIC ratios > 100. Median times above the MIC for free drug were 100% (twice daily) and 63% (once daily).
McGee
Bryan
B
Infectious Disease Pharmacokinetics Laboratory, National Jewish Health, Denver, Colorado, USA.
Dietze
Reynaldo
R
Hadad
David Jamil
DJ
Molino
Lucilia Pereira Dutra
LP
Maciel
Ethel Leonor Noia
EL
Boom
W Henry
WH
Palaci
Moises
M
Johnson
John L
JL
Peloquin
Charles A
CA
D000081:Acetamides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D023303:Oxazolidinones / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D055815:Young Adult
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid