Cytogenetics of pediatric acute myeloid leukemia.
Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease accounting for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. This article focuses on the significance of cytogenetic analysis in pediatric AML supporting the importance of cytogenetic analysis in the pathogenesis, diagnosis, prognosis, follow-up and treatment selection in childhood AML. It reviews in detail the types and frequencies of most common chromosomal aberrations, their molecular background, their correlation with French American British (FAB) subtypes and age distribution and their prognostic relevance. It also summarizes some less frequent or rare chromosome aberrations in which the prognostic classification has not been determined yet owning to the small number of patients and the variable treatment modalities used in different study groups. Furthermore, it discusses the association of specific chromosome rearrangements with prenatal exposure to carcinogenic agents or therapeutic agents and highlights the ongoing and future research on pediatric AML in the evolving field of Cytogenetics.
Manola
Kalliopi N
KN
Laboratory of Cytogenetics, National Center for Scientific Research, Demokritos, 15310 Aghia Paraskevi, Athens, Greece. pmanola@ipta.demokritos.gr
D002274:Carcinogens, Environmental / Q000009:adverse effects; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000187:drug effects; D003582:Cytogenetics / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics* / Q000473:pathology* / Q000628:therapy
D002274:Carcinogens, Environmental