title: Endonasal approaches to the sellar and parasellar regions: closure techniques using biomaterials.
abstract: OBJECTIVE
  We reviewed the clinical outcomes resulting from various closure techniques used following endoscopic endonasal surgery for lesions in the sellar and parasellar regions. We compared our current closure technique, which uses a biological matrix of native equine collagen (TissuDura) fixed with fibrin sealant (Tisseel), with the technique we employed previously, using autologous materials, in order to assess the comparative efficacy and tolerability of both methods over the medium- to long-term.
  
  
  METHODS
  A review was conducted of all cases of endonasal endoscopic intervention carried out in our institution between 1997 and 2007. Operations performed between January 1st 1997 and December 31st 2003 involved a sellar closure technique using autologous materials, either alone or supported by fibrin sealant. From January 1st 2004, sellar reconstruction techniques involving resorbable heterologous materials were used in the closure phases. Post-operatively, clinico-endoscopic assessments took place at 15 days, 1, 3, and 6 months and yearly thereafter, supplemented by magnetic resonance imaging (MRI) scanning at 3 months and annually.
  
  
  RESULTS
  Between January 1st 1997 and December 31st 2003, 79 operations were performed in which the sellar closure technique involved the use of autologous materials. Between January 1st 2004 and January 1st 2008, 125 operations were performed in which biomaterials were used for sellar closure. The incidence of complications (fluid fistula) was 2.5% in the autologous materials closure group and 1.6% in the biomaterials closure group. The most marked difference between the two approaches was seen at 1-month follow-up, when restoration of mucociliary transport in the sphenoidal sinus and physiological functionality of the nasal mucosa and paranasal sinuses were observed to be superior in the biomaterials patient cohort.
  
  
  CONCLUSIONS
  The development of biomaterials for closure of the sellar floor offers a viable alternative to traditional techniques using autologous materials.
authors: Department of Neurosurgery, IRCCS Policlinico S Matteo, University of Pavia, 27100 Pavia, Italy. dlocatelli@smatteo.pv.it
authors: D
authors: D
authors: Locatelli
authors: M
authors: M
authors: Vitali
authors: V M
authors: VM
authors: Custodi
authors: P
authors: P
authors: Scagnelli
authors: P
authors: P
authors: Castelnuovo
authors: F R
authors: FR
authors: Canevari
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D003094:Collagen / Q000627:therapeutic use; D004724:Endoscopy / Q000379:methods*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000033:anatomy & histology / Q000601:surgery; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods*; D013517:Otorhinolaryngologic Surgical Procedures / Q000295:instrumentation / Q000379:methods*; D010256:Paranasal Sinuses / Q000033:anatomy & histology / Q000502:physiology; D010900:Pituitary Diseases / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D019651:Plastic Surgery Procedures / Q000295:instrumentation / Q000379:methods; D020127:Recovery of Function / Q000502:physiology; D012189:Retrospective Studies; D012658:Sella Turcica / Q000473:pathology / Q000601:surgery*; D014182:Transplantation, Autologous / Q000379:methods / Q000706:statistics & numerical data; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D015718:Fibrin Tissue Adhesive; D003094:Collagen