[The expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding].
OBJECTIVE
To research the expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding.


METHODS
Detecting the expression of Bcl-2 and Bax protein in 40 cases of endometrium tissue of dysfunctional uterine bleeding patients with immunohistochemistry antibiotics protein-peroxide emzyme (SP)methods.


RESULTS
(1) The expression of Bcl-2 protein changes clearly and periodically in endometrium in normal cycle, the difference is obvious (P < 0.05). (2) The Bcl-2 protein develops with the hyperplasia in endometrium and the expression intensity is enhanced, the difference is obvious( P < 0.05). (3) The expression of Bax gene is masculine in endometrium in normal menstrual cycle. (4) The expression of Bax gene descends gradually with hyperplasia in uterine endometrium (P < 0.05).


CONCLUSIONS
Apoptosis of endometrium cell is restrained from the excessive expression of Bcl-2 protein and deficient expression of Bax protein, so the uterine endometrium gets to hyperplasia or notypical hyperplasia.
Zhou
Li-li
LL
The Hospital of Heilongliang Provine, Harbin 150036, China. lily_72_65@chinaren.com.cn
Yang
Li-na
LN
Wang
Li
L
D017209:Apoptosis / Q000502:physiology*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology*; D008796:Metrorrhagia / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology; D051028:bcl-2-Associated X Protein / Q000378:metabolism*
D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein