title: Spheroid array of fetal mouse liver cells constructed on a PEG-gel micropatterned surface: upregulation of hepatic functions by co-culture with nonparenchymal liver cells.
abstract: A spheroid array of fetal mouse liver cells, which comprise various immature cells, was constructed on a PEG-gel micropatterned surface and its hepatic activity and degree of differentiation induction were significantly upregulated by co-culture with nonparenchymal liver cells as feeder-cells.
authors: Graduate School of Pure and Applied Science, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan.
authors: Ryota
authors: R
authors: Kojima
authors: Keitaro
authors: K
authors: Yoshimoto
authors: Emiko
authors: E
authors: Takahashi
authors: Masahiro
authors: M
authors: Ichino
authors: Hirotoshi
authors: H
authors: Miyoshi
authors: Yukio
authors: Y
authors: Nagasaki
mesh_terms: D000818:Animals; D002417:Cattle; D002454:Cell Differentiation; D018920:Coculture Techniques; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism; D005782:Gels; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism*; D008099:Liver / Q000166:cytology*; D051379:Mice; D046228:Microarray Analysis / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry*; D018874:Spheroids, Cellular / Q000166:cytology* / Q000378:metabolism; D013499:Surface Properties
chemical_list: D005782:Gels; D011092:Polyethylene Glycols; D019388:Cytochrome P-450 CYP1A2