Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding.
Gender influences brain function including serotonergic neurotransmission, which may play a role in the well-known gender variations in vulnerability to mood and anxiety disorders. Even though hormonal replacement therapy in menopause is associated with globally increased cerebral 5-HT(2A) receptor binding it is not clear if gender or use of hormonal contraception exhibits associations with 5-HT(2A) receptor binding. We found no significant effect of gender on cortical 5-HT(2A) receptor binding (P=0.15, n=132). When adjusting for the personality trait neuroticism, known to be positively correlated to frontolimbic 5-HT(2A) receptor binding and to be more pronounced in women, again, the effect of gender was not significant (P=0.42, n=127). Also, the use of hormonal contraception (n=14) within the group of pre-menopausal women (total n=29) was not associated with cortical 5-HT(2A) receptor binding (P=0.31). In conclusion, neither gender, nor the use of hormonal contraception in premenopausal women was associated with cortical 5-HT(2A) receptor binding.
Frokjaer
V G
VG
Center for Integrated Molecular Brain Imaging and Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark. vibe@nru.dk
Erritzoe
D
D
Madsen
J
J
Paulson
O B
OB
Knudsen
G M
GM
D000293:Adolescent; D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007650:Ketanserin / Q000031:analogs & derivatives; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000502:physiology; D010552:Personality Assessment; D049268:Positron-Emission Tomography; D011485:Protein Binding; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D012727:Sex Characteristics; D055815:Young Adult
D003278:Contraceptives, Oral, Hormonal; D044402:Receptor, Serotonin, 5-HT2A; C071983:altanserin; D007650:Ketanserin