title: Failure of beta-cell function to compensate lack of insulin action in hyperuricemic subjects.
abstract: BACKGROUND
  Elevated serum uric acid has been related to insulin resistance, but there are no studies regarding its association with beta-cell function. In this study, we examine the response of beta-cell function to compensate insulin resistance in hyperuricaemic subjects.
  
  
  METHODS
  Population-based cross-sectional study. A total of 212 healthy individuals, men and non-pregnant women, aged 20-65 years, were randomly recruited and allocated into groups with hyperuricaemia or normouricaemia that were matched by value of Belfiore index. Hyperuricaemia was defined by serum uric acid concentration >or=416 micromol/L in men and >or=357 micromol/L in women. To evaluate the compensation of insulin secretion to variation of insulin sensitivity, we used a surrogate of the hyperbolic model of beta-cell function based on Belfiore and Homeostasis Model Analysis beta-cell (HOMA-ss) indexes; the area under curves (AUC) was calculated. The association between the uric acid levels and the AUC was estimated using a multivariate regression analysis adjusted by age, sex, and waist circumference.
  
  
  RESULTS
  Hyperuricaemia was identified in 77 (36.3%) individuals. A total of 39 (50.6%) hyperuricaemic and 44 (32.6%) normouricaemic subjects had diagnosis of impaired glucose tolerance (IGT), p = 0.01. In the total population, the AUCs in the hyperuricaemic and normouricaemic groups were 1.60725 cm(2) and 3.9819 cm(2), respectively (odds ratio [OR] 3.9; CI 95% 1.4-8.9). Among the 83 individuals with IGT, the AUCs in the subgroups with and without hyperuricaemia were 0.8495 cm(2) and 2.42075 cm(2), respectively (OR 2.7; CI 95% 1.3-10.1).
  
  
  CONCLUSIONS
  Our results show the failure of beta-cell function to compensate variation of insulin sensitivity in the hyperuricaemic individuals.
authors: Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.
authors: Luis E
authors: LE
authors: Simental-Mendía
authors: Martha
authors: M
authors: Rodríguez-Morán
authors: Fernando
authors: F
authors: Guerrero-Romero
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D000465:Algorithms; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000175:diagnosis; D006801:Humans; D033461:Hyperuricemia / Q000150:complications / Q000503:physiopathology*; D007328:Insulin / Q000097:blood / Q000502:physiology*; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology; D008875:Middle Aged; D016017:Odds Ratio; D012044:Regression Analysis; D012727:Sex Characteristics; D018709:Statistics, Nonparametric; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin