title: Pro-inflammatory cytokine genes influence the clinical features of frontotemporal lobar degeneration.
abstract: OBJECTIVE
  Recent studies suggested a role for pro-inflammatory mediators in frontotemporal lobar degeneration (FTLD). The objective of this study was to evaluate the association of functionally active polymorphisms in pro-inflammatory cytokine genes with the occurrence and the clinical features of the disease.
  
  
  METHODS
  Using a case-control study, we compared allelic and genotypic frequencies of several polymorphisms in the interleukin (IL)-1alpha, interleukin (IL)-1beta, interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha genes between 110 FTLD patients and 119 healthy controls.
  
  
  RESULTS
  No significant association between the examined polymorphisms and the disease was found. However, in comparison with remaining genotypes, patients carrying the T/T genotype of the IL-1beta gene showed a significantly lower age at onset of the disease. In addition, scores of the Frontal Assessment Battery were significantly modified by the IL-6 -174G>C polymorphism.
  
  
  CONCLUSIONS
  Our findings support a role for pro-inflammatory cytokine genes in the pathogenesis of frontotemporal lobar degeneration.
authors: Neurology II, Department of Neuroscience, University of Turin, IT-10126 Turin, Italy. irainero@molinette.piemonte.it
authors: Innocenzo
authors: I
authors: Rainero
authors: Elisa
authors: E
authors: Rubino
authors: Giorgetta
authors: G
authors: Cappa
authors: Eugenia
authors: E
authors: Rota
authors: Walter
authors: W
authors: Valfrè
authors: Patrizia
authors: P
authors: Ferrero
authors: Pierpaola
authors: P
authors: Fenoglio
authors: Denisa
authors: D
authors: Baci
authors: Giuseppina
authors: G
authors: D'Amico
authors: Giovanna
authors: G
authors: Vaula
authors: Salvatore
authors: S
authors: Gallone
authors: Lorenzo
authors: L
authors: Pinessi
mesh_terms: D017668:Age of Onset; D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D016207:Cytokines / Q000235:genetics*; D004247:DNA / Q000235:genetics; D003704:Dementia / Q000235:genetics* / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D007378:Interleukins / Q000235:genetics; D007558:Italy; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D001057:Apolipoproteins E; D016207:Cytokines; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D004247:DNA