title: Dietary regulation of P-gp function and expression.
abstract: Food-drug interactions have been associated with clinically important pharmacokinetic and pharmacodynamic changes of a drug. The aim of this paper is to review the regulation of P-glycoprotein (P-gp) by dietary components and to correlate the changes in cellular P-gp function and expression with drug bioavailability. In summary, the published literature has provided extensive data supporting the modulation of drug bioavailability through P-gp regulation by components in food groups such as fruit juices, spices, herbs, cruciferous vegetables and green tea. Most of these data were, however, derived from in vitro cell models and, except for the St John's wort, the clinical significance of most reported interactions remains to be clarified. Studies on piperine and capsaicin have underscored an often poor correlation between in vivo and in vitro data, whereas experiments involving curcumin highlighted differences between acute and chronic consumption of a dietary component on P-gp function and expression in vivo. A better understanding of the pharmacokinetic and pharmacodynamic profiles of the dietary components will aid in addressing these knowledge gaps.
authors: National Cancer Center Singapore, Singapore.
authors: Wenxia
authors: W
authors: Zhang
authors: Yi
authors: Y
authors: Han
authors: Siok Lam
authors: SL
authors: Lim
authors: Lee Yong
authors: LY
authors: Lim
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D004032:Diet; D018565:Food-Drug Interactions / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D041743:Herb-Drug Interactions / Q000502:physiology; D006801:Humans
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1