Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report.
Rheumatoid arthritis (RA) is an autoimmune disease mediated by inflammatory processes mainly at the joints. Recently, awareness of Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD) has been heightened for its association with methotraxate usage in RA patients. In the contrary, acute myeloid leukemia with multilineage dysplasia (AML-MLD) has never been documented to be present concomitantly with the above two conditions. In this report we present a case of an autopsy-proven co-existence of AML-MLD and EBV-associated T-LPD in a patient with RA.
Tokuhira
Michihide
M
Division of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan. tokuhira@saitama-med.ac.jp
Hanzawa
Kyoko
K
Watanabe
Reiko
R
Sekiguchi
Yasunobu
Y
Nemoto
Tomoe
T
Toyozumi
Yasuo
Y
Tamaru
Jun-ichi
J
Itoyama
Shinji
S
Suzuki
Katsuya
K
Kameda
Hideto
H
Mori
Shigehisa
S
Kizaki
Masahiro
M
D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D019070:Cell Lineage; D003933:Diagnosis; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000473:pathology