title: Risk-factors for non-adherence to antiretroviral therapy.
abstract: Cross-sectional study analyzed as case-control to identify risk factors for non-adherence to antiretroviral therapy. We studied 412 out-clinics HIV infected subjects of three public hospitals of Recife, Pernambuco. The objective was to examine the association between non-adherence to the antiretroviral therapy and biological, social-behavior and demographics and economic factors, factors related to the disease and/or treatment, factors related to life habits and depression symptoms. Variables significantly associated with non-adherence to antiretroviral therapy were: time elapsed since HIV diagnosis (p = 0.002), daily dose (p = 0.046), use of alcohol (p = 0.030) and past drug use (p = 0.048), and borderline p-values were found for educational level (p = 0.093) and family monthly income (p = 0.08). In the multivariable analysis, the factors that remained in the final model were family monthly income, time period with HIV infection and use of alcohol. No association was observed between non-adherence to antiretroviral therapy and gender, age, sexual orientation, marital status, educational level and place of residence. Based on our results and the local situation we suggest: assessment of social needs; training of partners and/or families on supporting adherence, creation of 'adherence groups' to motivate and to reassure patients on the benefits of treatment; counseling and/or psychotherapy for alcohol drinkers.
authors: Departamento de Medicina Tropical, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego S/N, Recife, Pernambuco, Brazil. marcia.fraga@ig.com.br
authors: Márcia Cristina Fraga
authors: MC
authors: Silva
authors: Ricardo Arraes de Alencar
authors: RA
authors: Ximenes
authors: Demócrito Barros
authors: DB
authors: Miranda Filho
authors: Luciano Wagner de Melo Santiago
authors: LW
authors: Arraes
authors: Mecleine
authors: M
authors: Mendes
authors: Ana Caroline de Sobral
authors: AC
authors: Melo
authors: Paola Rebeka de Melo
authors: PR
authors: Fernandes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D012307:Risk Factors; D012959:Socioeconomic Factors; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents