Animal models of thrombosis.
OBJECTIVE
The thrombotic response to vascular injury is an important clinical problem that mediates most vascular disease complications. Thrombus formation involves an integrated response that is influenced by blood flow, multiple cell types, and numerous circulating factors. As a result, modeling of this complex response using in-vitro or in-silico strategies is insufficient. The use of animal models of thrombosis provides a critical tool for the discovery and initial testing of novel therapies for vascular thrombosis.


RESULTS
The literature from 2008 to the present provides significant advances in regard to novel models of arterial thrombosis, novel mechanisms underlying thrombus formation, new models and mechanisms related to thrombotic stroke, and preclinical advances in therapeutics for vascular thrombosis.


CONCLUSIONS
The formation of occlusive thrombi is complex, involving the integration of many molecular interactions and cell types at the site of vascular injury. The identification of strategies to suppress occlusive thrombus formation without undermining normal hemostatic function is the primary goal of this area of study.
Bodary
Peter F
PF
Department of Movement Science, School of Kinesiology, University of Michigan Medical School, Ann Arbor, MI 48109-2214, USA. pfbodary@umich.edu
Eitzman
Daniel T
DT
D000818:Animals; D004195:Disease Models, Animal; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy