title: Meta-analysis: clinicopathological and prognostic significance of cyclooxygenase-2 expression on oesophageal squamous cell carcinoma.
abstract: BACKGROUND
  Cyclooxygenase-2 (COX-2) is involved in oesophageal carcinogenesis, but the clinical and prognostic significance of COX-2 expression in oesophageal squamous cell carcinoma (ESCC) remains controversial.
  
  
  OBJECTIVE
  To evaluate the clinicopathological and prognostic role of COX-2 expression in ESCC.
  
  
  METHODS
  Studies assessing clinical or prognostic significance of COX-2 expression in ESCC published until December 2008 were selected. A meta-analysis was performed to clarify the impact of COX-2 expression on clinicopathological parameters or overall survival (OS) in ESCC.
  
  
  RESULTS
  A total of 19 studies met the inclusion criteria, among which 17 studies were about the clinicopathological significance of COX-2 expression in ESCC, 12 studies were dealing with prognostic role of COX-2 expression in ESCC and 10 studies evaluated both of them. Overexpression of COX-2 was significantly correlated with not only the depth of invasion and TNM stage, with a combined odds ratio (OR) of 0.55 (95%CI: 0.34-0.90, Z = 2.41, P = 0.02) and 0.55 (95%CI: 0.32-0.95, Z = 2.13, P = 0.03) respectively but also the reduced OS with relative risk (RR) 1.42, 95% CI: 1.07-1.90, Z = 2.43, P = 0.02).
  
  
  CONCLUSIONS
  COX-2 might play an important role in the progress of ESCC, overexpression of COX-2 correlates with not only the depth of invasion and TNM stage but also the reduced OS. COX-2 might be a potential therapy target for ESCC and work as a prognostic factor for ESCC patients, yet the clinicopathological and prognostic role of COX-2 in ESCC still needs further confirmation by well-designed prospective studies.
authors: Department of Medical Statistics, Guangdong College of Pharmacy, Guangzhou, China.
authors: L
authors: L
authors: Li
authors: J
authors: J
authors: Zhao
authors: Z
authors: Z
authors: Wu
authors: G
authors: G
authors: Wang
authors: G
authors: G
authors: Chen
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors
chemical_list: D051546:Cyclooxygenase 2