[Individual chronotherapy of essential hypertension and compliance of patients with treatment scheme].
OBJECTIVE
To raise compliance of hypertensive patients with treatment scheme using individual chronotherapy.


METHODS
Hypertensive patients were divided into two groups: the study group consisted of 225 patients, the comparison group--125 patients. The protocol comprised examination of the circadian blood pressure profile (CBPP), complex of BP indices, personal reaction to the disease (the psychodiagnostic test).


RESULTS
The normal type of the circadian BP profile (dipper) was found only in 44.4% patients; 36, 120.2 and 9.3% patients were non-dippers, night-peakers and over-dippers, respectively. Only 51.6% patients had adaptive types of reaction to the disease. After half a year of individual antihypertensive treatment CBPP improved, adaptation to the disease was registered 1.5 times more often. 76% patients developed stable motivation to long-term treatment of hypertension.


CONCLUSIONS
For adequate and safe chronotherapy of essential hypertension it is necessary to know an individual circadian rhythm of BP. Motivation to long-term pharmacotherapy is the best in patients with adaptive reaction to the disease. Education of hypertensive patients must be conducted in conditions of psychological comfort. Positive changes in life style and motivation to treatment should be promoted.
Khromtsova
O M
OM
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D019454:Chronotherapy / Q000379:methods*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
D000959:Antihypertensive Agents