title: Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease.
abstract: OBJECTIVE
  To explain the role of oxidative stress in the pathology of celiac disease.
  
  
  METHODS
  The activities of antioxidant enzymes and the levels of glutathione and lipid hydroperoxides were measured in the samples of small intestinal biopsies from 39 children with different forms of the disease and in 19 control subjects.
  
  
  RESULTS
  The activities of analyzed enzymes varied significantly between the examined groups. An increase in the activities of superoxide dismutase was observed in patients with active and silent celiac disease, while the activities of glutathione peroxidase and glutathione reductase and the glutathione content were significantly reduced. The level of lipid hydroperoxides was significantly elevated in these groups.
  
  
  CONCLUSIONS
  Oxidative stress is an important factor in the pathogenesis of celiac disease. The antioxidant capacity of celiac patients is significantly reduced, mostly by a depletion of glutathione. Natural antioxidants and appropriate dietary supplements could be important complements to the classic therapy of celiac disease.
authors: Laboratory of Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia. vesnas@vinca.rs
authors: Vesna
authors: V
authors: Stojiljković
authors: Ana
authors: A
authors: Todorović
authors: Snezana
authors: S
authors: Pejić
authors: Jelena
authors: J
authors: Kasapović
authors: Zorica S
authors: ZS
authors: Saicić
authors: Nedeljko
authors: N
authors: Radlović
authors: Snezana B
authors: SB
authors: Pajović
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D002446:Celiac Disease / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D007421:Intestine, Small / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation; D008297:Male; D055771:Serbia; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione; D019803:Glutathione Disulfide