Nuclear receptors and their role in Epstein -- Barr virus induced B cell transformation.
Epstein - Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection six EBV-encoded nuclear antigens (EBNAs) and three latent membrane proteins (LMPs) are expressed in the transformed cells that can grow as a lymphoblastoid cell lines in vitro . These proteins hijack the normal B cell growth pathways by activating the constitutive growth promotion and external survival signals. We have determined a set of the nuclear receptors that are up- (and down-) regulated in the latency III infected cells at the mRNA level. In the present paper we discussed the possible role of these receptors in B cell transformation upon EBV infection based on the literature data.
Yenamandra
S P
SP
Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm S17177, Sweden.
Klein
G
G
Kashuba
E
E
D000818:Animals; D001402:B-Lymphocytes / Q000821:virology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D020031:Epstein-Barr Virus Infections / Q000235:genetics / Q000378:metabolism*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
D019309:Epstein-Barr Virus Nuclear Antigens; D018160:Receptors, Cytoplasmic and Nuclear