gPS navigates germ cells to pluripotency.
The establishment of pluripotent stem cell lines from explanted testes has been hampered by a poor understanding of their cellular origin. In this issue of Cell Stem Cell, Ko et al. (2009) reproducibly generate pluripotent cell lines from murine testes and unequivocally demonstrate their origin from spermatogonial stem cells.
Geijsen
Niels
N
Massachusetts General Hospital Center for Regenerative Medicine and Cancer Center, Harvard Stem Cell Institute, Boston, MA 02114, USA. ngeijsen@mgh.harvard.edu
Hochedlinger
Konrad
K
D000818:Animals; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D005854:Germ Cells / Q000166:cytology* / Q000254:growth & development; D008297:Male; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology*; D013737:Testis / Q000166:cytology*