Lack of association of angiotensin-converting enzyme insertion/deletion polymorphism and myocardial infarction at very young ages.
We examined whether angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism is associated with the development of myocardial infarction (MI) at < or = 35 years of age. The study sample consisted of 201 patients with premature MI and 140 age- and sex-matched healthy individuals. No difference was found in the distribution of ACE genotypes between the patients and controls. A higher prevalence of the DD genotype among hypertensives was found compared with the non-hypertensive patients (62.5% vs 35.6%, p = 0.01). ACE polymorphism is not associated with the development of premature MI and this might be due to the low prevalence of hypertension in young coronary patients.
Rallidis
Loukianos S
LS
Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Greece.
Gialeraki
Argyri
A
Varounis
Christos
C
Dagres
Nikolaos
N
Kotakos
Christos
C
Travlou
Anthi
A
Lekakis
John
J
Kremastinos
Dimitrios T
DT
D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017384:Sequence Deletion
D007703:Peptidyl-Dipeptidase A