Spectral analysis of field potential recordings by deep brain stimulation electrode for localization of subthalamic nucleus in patients with Parkinson's disease.
OBJECTIVE
Spectral analysis of local field potential (LFP) recorded by deep brain stimulation (DBS) electrode around the subthalamic nucleus (STN) in patients with Parkinson's disease was performed.


METHODS
The borders of the STN were determined by microelectrode recording. The most eligible trajectory for the sensorimotor area of the STN was used for LFP recording while advancing the DBS electrode.


RESULTS
The low-frequency LFP power (theta- to beta-band) increased from a few millimeters above the dorsal border of the STN defined by microelectrode recording; however, the low-frequency power kept the same level beyond the ventral border of the STN. Only high beta-power showed close correlation to the dorsal and ventral borders of the STN.


CONCLUSIONS
A spectral power analysis of LFP recording by DBS electrode helps with the final confirmation of the dorsal and ventral borders of the STN of Parkinson's disease in DBS implantation surgery.
Miyagi
Yasushi
Y
Division of Digital Patient, Digital Medicine Initiative, Kyushu University, Higashi-ku, Fukuoka, Japan. yamiyagi@digital.med.kyushu-u.ac.jp
Okamoto
Tsuyoshi
T
Morioka
Takato
T
Tobimatsu
Shozo
S
Nakanishi
Yoshitaka
Y
Aihara
Kazuyuki
K
Hashiguchi
Kimiaki
K
Murakami
Nobuya
N
Yoshida
Fumiaki
F
Samura
Kazuhiro
K
Nagata
Shinji
S
Sasaki
Tomio
T
D000368:Aged; D001931:Brain Mapping / Q000379:methods; D046690:Deep Brain Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000033:anatomy & histology / Q000502:physiology*