title: Pharmacotherapy of sarcoma.
abstract: BACKGROUND
  Comprising < 1% of adult malignancies and approximately 12% of pediatric malignancies, sarcomas are derived from a variety of connective tissues and exhibit highly variable responsiveness to therapy. The clinical and biologic heterogeneity of the > 50 histologic subtypes of sarcomas often require different therapeutic approaches.
  
  
  OBJECTIVE
  This review describes the use of therapeutic agents in the management of bone and soft-tissue sarcomas.
  
  
  METHODS
  Relevant literature is identified and presented from major conference proceedings, as well as using the PubMed search engine.
  
  
  CONCLUSIONS
  Chemotherapy has improved outcomes over the past few decade, particularly in patients with certain bone sarcomas and gastrointestinal stromal tumors; while in the majority of patients, additional strategies are necessary.
authors: University of Michigan, C407 Med Inn Building, 1500 E. Medical Center Dr, SPC 5848, Ann Arbor, MI 48109-5848, USA. rashmim@umich.edu
authors: Rashmi
authors: R
authors: Chugh
authors: Laurence H
authors: LH
authors: Baker
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy*; D006801:Humans; D012509:Sarcoma / Q000188:drug therapy*