title: A case of Vogt-Koyanagi-Harada disease in a patient with Graves disease.
abstract: A case of Vogt-Koyanagi-Harada disease (VKH) that developed in a 36-year-old woman with Graves' disease was described. The patient was treated with Lugol's solution and presented with bilateral serous retinal detachment. She had also suffered from methimazole-induced hypersensitivity and steroid-induced myopathy. Fluorescein angiography showed multiple leakage points and a lumbar puncture revealed pleocytosis, which was compatible with VKH. High dose steroid pulse therapy was successful. Altered immune regulation associated with drug-induced hypersensitivity may contribute to the development of VKH in patients with Graves' disease.
authors: Department of Ophthalmology, College of Medicine, and Medical Research Center, Seoul National University, Seoul, Korea.
authors: Je Hyun
authors: JH
authors: Seo
authors: Hyeong Gon
authors: HG
authors: Yu
authors: Hum
authors: H
authors: Chung
mesh_terms: D000328:Adult; D004396:Coloring Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000008:administration & dosage; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007275:Injections, Intravenous; D007454:Iodides / Q000008:administration & dosage; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D004396:Coloring Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D007454:Iodides; D009883:Ophthalmic Solutions; C010389:Lugol's solution