title: Revisiting bioaccumulation criteria for POPs and PBT assessments.
abstract: Scientists from academia, industry, and government reviewed current international regulations for the screening of commercial chemicals for bioaccumulation in the context of the current state of bioaccumulation science. On the basis of this review, several recommendations were proposed, including a scientific definition for "bioaccumulative substances," improved criteria for the characterization of bioaccumulative substances (including the trophic magnification factor and the biomagnification factor), novel methods for measuring and calculating bioaccumulation properties, and a framework for screening commercial chemicals for bioaccumulative substances. The proposed framework for bioaccumulation screening improves current practices by reducing miscategorization, making more effective use of available bioaccumulation data that currently cannot be considered, reducing the need for animal testing, providing simpler and cheaper test protocols for animal studies in case animal studies are necessary, making use of alternative testing strategies, including in vitro and in silico metabolic transformation assays, and providing a scientific foundation for bioaccumulation screening that can act to harmonize bioaccumulation screening among various jurisdictions.
authors: School of Resource and Environmental Management, Simon Fraser University, Burnaby, British Columbia V5A1S6, Canada. gobas@sfu.ca
authors: Frank A P C
authors: FA
authors: Gobas
authors: Watze
authors: W
authors: de Wolf
authors: Lawrence P
authors: LP
authors: Burkhard
authors: Eric
authors: E
authors: Verbruggen
authors: Kathleen
authors: K
authors: Plotzke
mesh_terms: D000818:Animals; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis* / Q000378:metabolism; D020387:Food Chain; D006801:Humans; D008962:Models, Theoretical; D018570:Risk Assessment / Q000379:methods*
chemical_list: D004785:Environmental Pollutants