title: Rapid and dynamic intracellular patterning of cell-internalized magnetic fluorescent nanoparticles.
abstract: Conjugated magnetic nanoparticles have recently demonstrated potential in activating unique and specific activity within cells. Leveraging microfabrication, we have developed a technique of localizing nanoparticles to specific, subcellular locations by a micropatterned ferromagnetic substrate. Controlled patterns of nanoparticles were assembled and dynamically controlled with submicrometer precision within live cells. We anticipate that the technique will be useful as a compact, simple method of generating localizable, subcellular chemical and mechanical signals, compatible with standard microscopy.
authors: Department of Electrical Engineering, California Nanosystems Institute, University of California, Los Angeles, Los Angeles, California, USA. ptseng@ucla.edu
authors: Peter
authors: P
authors: Tseng
authors: Dino
authors: D
authors: Di Carlo
authors: Jack W
authors: JW
authors: Judy
mesh_terms: D002478:Cells, Cultured; D008280:Magnetics; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D013499:Surface Properties; D013997:Time Factors