Differential diagnosis and treatment of primary, cutaneous, anaplastic large cell lymphoma: not always an easy task.
Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a rare and distinct neoplasm appearing de novo on the skin. We present a case of a 75-year-old man diagnosed with PC-ALCL in his left femoral region. We describe the morphology of lesions along with the differential diagnosis, treatment, clinical course and prognosis. We further discuss parameters concerning treatment that should be considered when a PC-ALCL is diagnosed. Our case report demonstrates the complexity in classification, staging, differential diagnosis and therapy selection of PC-ALCLs. It is crucial to emphasize the importance of clinical criteria in diagnosing a PC-ALCL in combination with immunohistochemistry.
Diamantidis
Michael D
MD
Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece. diamantidis79@yahoo.gr.
Papadopoulos
Athanasios
A
Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
Kaiafa
Georgia
G
Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
Ntaios
George
G
Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
Karayannopoulou
Georgia
G
Department of Pathology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Kostopoulos
Ioannis
I
Department of Pathology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Girtovitis
Fotios
F
Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
Saouli
Zoi
Z
Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
Kontoninas
Zisis
Z
Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
Raptis
Ioannis D
ID
Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
Savopoulos
Christos
C
Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
Hatzitolios
Apostolos
A
Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece.
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone