Dimethoxyaporphine as an antagonist of chemical excitation in the pigeon optic tectum.
The alkaloid L-5,6-dimethoxyaporphine (L-nuciferine) was studied with iontophoretic techniques, and its interaction with excitant amino acids on neurones of the pigeon optic tectum was tested. This compound antagonizes the action of L-glutamate and, to a weaker extent, that of L-aspartate and d,L-homocysteate. In comparison, L-5,6-dimethoxyaporphine did not reduce the acetylcholine evoked excitation.
Felix
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D
Brain Research Institute, University of Zürich, 8029 Zürich, Switzerland.
Frangi
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U