title: First structural insights into the TpsB/Omp85 superfamily.
abstract: Proteins of the TpsB/Omp85 superfamily are involved in protein transport across, or assembly into, the outer membrane of Gram-negative bacteria, and their distant eukaryotic relatives exert similar functions in chloroplasts and mitochondria. The X-ray structure of one TpsB transporter, FhaC, provides the bases to decipher the mechanisms of action of these proteins. With two POTRA domains in the periplasm, a transmembrane beta barrel and a large loop harboring a functionally important motif, FhaC epitomizes the conserved features of the super-family.
authors: INSERM U629, Institut Pasteur de Lille, 1 rue Calmette, F-59019 Lille cedex, France. francoise.jacob@ibl.fr
authors: Françoise
authors: F
authors: Jacob-Dubuisson
authors: Vincent
authors: V
authors: Villeret
authors: Bernard
authors: B
authors: Clantin
authors: Anne-Sophie
authors: AS
authors: Delattre
authors: Nathalie
authors: N
authors: Saint
mesh_terms: D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry*; D029968:Escherichia coli Proteins / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment
chemical_list: D001425:Bacterial Outer Membrane Proteins; C503914:BamA protein, E coli; D029968:Escherichia coli Proteins