title: [Experimental study of PVPP/silicone composite automatic expanded material as implants].
abstract: OBJECTIVE
  To study the feasibility of Polyvinylpolypyrrolidone (PVPP)/silicone composite automatic expanded material as implants.
  
  
  METHODS
  The PVPP hydrogel was mixed with silicone through the location at the high temperature. Implants with different ratio of PVPP to silicone were placed under the back and nose skin in 24 New Zealand rabbits. The surrounding tissue reaction, material and skin expansion were observed and compared with those with pure silicone implants.
  
  
  RESULTS
  The study lasted for 200 days. Compared with pure silicone implants, the composite material could expand automatically and stop expanding at about 2 weeks after implantation. Histological study showed similar inflectional and foreign body reaction around the composite material and the pure silicone.
  
  
  CONCLUSIONS
  Compared with pure silicone, the PVPP/silicone composite implant has the advantage of automatic expansion, so as to expand the soft tissue.
authors: Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China.
authors: Wei-min
authors: WM
authors: Yin
authors: Jian-hua
authors: JH
authors: Gao
authors: Qing-fang
authors: QF
authors: Yang
authors: Feng
authors: F
authors: Lu
authors: Jia-jia
authors: JJ
authors: Ye
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D008297:Male; D008422:Materials Testing; D011205:Povidone / Q000031:analogs & derivatives*; D019736:Prostheses and Implants; D011474:Prosthesis Design; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; C077842:polyvinylpolypyrrolidone; D011205:Povidone