title: Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study.
abstract: BACKGROUND
  No previous study has examined the comorbidity of Irritable Bowel Syndrome (IBS) and Generalized Anxiety Disorder (GAD) in a general population using standardized diagnostic methods.
  
  
  OBJECTIVE
  To examine the prevalence, comorbidity and risk correlates of IBS and GAD in a general population.
  
  
  METHODS
  A random community-based telephone survey was conducted. The questionnaire covered symptoms of IBS, GAD, core depressive symptoms, help-seeking behaviour and functional impairment on the Sheehan Disability Scale.
  
  
  RESULTS
  A total of 2005 participants completed the interview. The current prevalence of IBS was 5.4% and the 12-month prevalence of GAD was 4%. GAD was five times more common among IBS respondents than non-IBS respondents (OR: 5.84, P < 0.001), whereas IBS was 4.7 times more common among GAD respondents than among non-GAD respondents (OR: 6.32, P < 0.001). Core depressive symptoms (OR: 6.25, P < 0.01) and education level (OR: 5.918, P = 0.021) were risk correlates of GAD among IBS respondents. Comorbid respondents were more impaired than respondents having either disorder alone, but were not more likely to seek professional help than IBS-only respondents.
  
  
  CONCLUSIONS
  Irritable Bowel Syndrome and GAD comorbidity was common and added to impairment in the community. The strong association between psychiatric morbidity and IBS observed in referral centres was not a consequence of increased help-seeking behaviour.
authors: Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong. singlee@cuhk.edu.hk
authors: S
authors: S
authors: Lee
authors: J
authors: J
authors: Wu
authors: Y L
authors: YL
authors: Ma
authors: A
authors: A
authors: Tsang
authors: W-J
authors: WJ
authors: Guo
authors: J
authors: J
authors: Sung
mesh_terms: D000293:Adolescent; D000328:Adult; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology*; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000453:epidemiology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D055815:Young Adult