title: [Rehabilitation in haemophilic children with inhibitors using recombinant activated factor VII].
abstract: BACKGROUND
  During invasive and orthopaedic procedure of the joints, physical therapy is a necessary modality for successful recovery, especially in patients with haemophilia. These patients require concurrent substitution therapy. Recombinant activated factor VII (rFVIIa) has been successfully used in treating haemophilia with inhibitor, especially during preoperative preparation. Nevertheless, optimal substitution therapy during perioperative physical therapy has been poorly defined.
  
  
  METHODS
  In our paper, we review the literature and the course of perioperative rehabilitation after synovectomy in a 16-year-old haemophilic patient with high-titre inhibitor, treated with rFVIIa. Rehabilitation was started on day 3 after surgery, with rFVIIa substitution lasting ten days and followed by intermittent dosages during episodes of pain. After concluding physical treatment, a significantly better function of the operated joint was recorded, which led to the recovery of walking without orthopaedic aid.
  
  
  CONCLUSIONS
  Patients with inhibitors require individualized approach of a multidisciplinary team in order to achieve optimal results in elective orthopaedic procedures.
authors: Dragana
authors: D
authors: Janić
authors: Ivana
authors: I
authors: Petronić
authors: Lidija
authors: L
authors: Dokmanović
authors: Nada
authors: N
authors: Krstovski
authors: Jelena
authors: J
authors: Lazić
authors: Predrag
authors: P
authors: Rodić
mesh_terms: D000293:Adolescent; D015942:Factor VIIa / Q000627:therapeutic use*; D006395:Hemarthrosis / Q000209:etiology / Q000601:surgery*; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D006490:Hemostatics; D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa