title: Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3).
abstract: A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain.
authors: Department of Medicinal Chemistry, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA. scott_d_kuduk@merck.com
authors: Scott D
authors: SD
authors: Kuduk
authors: Ronald K
authors: RK
authors: Chang
authors: Jenny M-C
authors: JM
authors: Wai
authors: Christina N
authors: CN
authors: Di Marco
authors: Victoria
authors: V
authors: Cofre
authors: Robert M
authors: RM
authors: DiPardo
authors: Sean P
authors: SP
authors: Cook
authors: Matthew J
authors: MJ
authors: Cato
authors: Aneta
authors: A
authors: Jovanovska
authors: Mark O
authors: MO
authors: Urban
authors: Michael
authors: M
authors: Leitl
authors: Robert H
authors: RH
authors: Spencer
authors: Stefanie A
authors: SA
authors: Kane
authors: George D
authors: GD
authors: Hartman
authors: Mark T
authors: MT
authors: Bilodeau
mesh_terms: D062565:Acid Sensing Ion Channels; D000578:Amidines / Q000737:chemistry*; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004594:Electrophysiology; D007211:Indoles / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007473:Ion Channels / Q000737:chemistry; D008297:Male; D008956:Models, Chemical; D009288:Naproxen / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015222:Sodium Channels / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: C112231:ASIC3 protein, human; D062565:Acid Sensing Ion Channels; D000578:Amidines; D007211:Indoles; D007473:Ion Channels; D015222:Sodium Channels; D009288:Naproxen