Rifampin-associated pseudomembranous colitis.
Pseudomembranous colitis (PMC) is known to develop after antibiotic treatment, but is rarely associated with antituberculosis (anti-TB) agents. We report a 28-year-old woman without underlying diseases developing PMC after 126 days of anti-TB treatment. Severe diarrhea and abdominal cramping pain were experienced. Colonoscopic biopsy proved the diagnosis of PMC. Her symptoms improved after discontinuing the anti-TB agents but recurred shortly after challenging with rifampin and isoniazid. Metronidazole administration and replacement of rifampin with levofloxacin successfully cured the PMC. Our report supports the notion that rifampin can induce PMC.
Chen
Tun-Chieh
TC
Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan.
Lu
Po-Liang
PL
Lin
Wei-Ru
WR
Lin
Chun-Yu
CY
Wu
Jeng-Yih
JY
Chen
Yen-Hsu
YH
D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D016360:Clostridioides difficile / Q000187:drug effects; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D012293:Rifampin / Q000009:adverse effects*
D000995:Antitubercular Agents; D012293:Rifampin