title: Stereotactic body radiotherapy for isolated para-aortic lymph node recurrence after curative resection in gastric cancer.
abstract: The aim of this study was to investigate whether stereotactic body radiotherapy (SBRT) can salvage gastric cancer patients with para-aortic lymph node (PALN) recurrence. From January 2003 to December 2006, 7 patients were treated for isolated PALN recurrence from gastric cancer after curative resection. Follow up durations ranged from 19 to 33 months (median; 26 months), and SBRT doses from 45 Gy to 51 Gy (median 48 Gy) in 3 fractions. Disease progression-free and overall survivals and toxicities were recorded. Response to treatment was assessed by computed tomography. Final patient outcomes were as follows: 2 were alive without evidence of disease, 3 remained alive with disease, and 2 patients died of disease. Five of 7 patients showed complete response and 2 patients partial response between 3 and 11 months after SBRT. Three-year overall and disease progression-free survival rates post-SBRT were 43% and 29%, respectively. No severe complication was detected during follow-up. Selected patients with isolated PALN recurrence can be salvaged by SBRT without severe complications.
authors: Department of Radiation Oncology, Korea Institute of Radiological & Medical Sciences, Seoul, Korea. mskim@kcch.re.kr
authors: Mi-Sook
authors: MS
authors: Kim
authors: Sung Yul
authors: SY
authors: Yoo
authors: Chul Koo
authors: CK
authors: Cho
authors: Hyung Jun
authors: HJ
authors: Yoo
authors: Kwang Mo
authors: KM
authors: Yang
authors: Jin Kyu
authors: JK
authors: Kang
authors: Dong Han
authors: DH
authors: Lee
authors: Jong Inn
authors: JI
authors: Lee
authors: Ho Youn
authors: HY
authors: Bang
authors: Min Suk
authors: MS
authors: Kim
authors: Hae Jin
authors: HJ
authors: Kang
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy* / Q000601:surgery; D016634:Radiosurgery; D011879:Radiotherapy Dosage; D012008:Recurrence; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis