title: Association of white-matter lesions with brain atrophy markers: the three-city Dijon MRI study.
abstract: BACKGROUND
  Brain atrophy and white-matter lesions (WML) are common features at cerebral MRI of both normal and demented elderly people. In a population-based study of 1,792 elderly subjects aged 65-80 years, free of dementia, who had a cerebral MRI at entry, we investigated the relationship between WML volume and brain atrophy markers estimated by hippocampal, gray matter (GM) and cerebrospinal fluid (CSF) volumes.
  
  
  METHODS
  An automated algorithm of detection and quantification of WML was developed, and voxel-based morphometry methods were used to estimate GM, CSF and hippocampal volumes. To evaluate the relation between those volumes and WML load, we used analysis of covariance and multiple linear regression models adjusting for potential confounders and total intracranial volumes.
  
  
  RESULTS
  Age was highly correlated with WML load and all brain atrophy markers. Total WML volume was negatively associated with both GM (beta = -0.03, p < 0.0001) and hippocampal volumes (beta = -0.75, p = 0.0009) and positively with CSF volumes (beta = 0.008, p = 0.02) after controlling for sex, age, education level, hypertension and apolipoprotein E genotype. Evidence for a relationship between brain atrophy markers and WML was stronger for periventricular WML. We found that the relationship between WML and hippocampal volumes was independent of other brain tissue volumes.
  
  
  CONCLUSIONS
  These results suggest that, in the brain of nondemented elderly subjects, degenerative processes and vascular changes co-occur and are related independently of vascular risk factors.
authors: Inserm U708 'Neuroepidemiology', Paris, France. godin@chups.jussieu.fr
authors: Ophélia
authors: O
authors: Godin
authors: Pauline
authors: P
authors: Maillard
authors: Fabrice
authors: F
authors: Crivello
authors: Annick
authors: A
authors: Alpérovitch
authors: Bernard
authors: B
authors: Mazoyer
authors: Christophe
authors: C
authors: Tzourio
authors: Carole
authors: C
authors: Dufouil
mesh_terms: D000368:Aged; D000465:Algorithms; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000150:complications / Q000473:pathology*; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology; D003704:Dementia / Q000209:etiology / Q000473:pathology; D005260:Female; D005602:France; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D009929:Organ Size; D011159:Population Surveillance; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index