title: Gene expression profiles in the prefrontal cortex of SHR rats by cDNA microarrays.
abstract: We have undertaken cDNA microarrays to identify differentially expressed genes in the prefrontal cortex (PFC) of spontaneously hypertensive-rat (SHR), a rodent model of attention deficit hyperactivity disorder (ADHD) versus control Wistar-Kyoto (WKY) rats. The analysis of the gene expression profiles indicated that 57 genes were up-regulated and 97 genes were down-regulated in the PFC of SHR. These predominately expressed genes included genes involved in neural development, immunity, transcription factor, monoamine neurotransmitter, metabolism, signal transduction, apoptosis and so on. Although more detailed analyses are necessary, it is anticipated that further study of genes identified will provide insights into their specific roles in the etiology of ADHD.
authors: Department of Pediatrics, Nanjing Maternity and Child Health Hospital of Nanjing Medical University, 210004, Nanjing, China. jieqiu@yahoo.cn
authors: Jie
authors: J
authors: Qiu
authors: Qin
authors: Q
authors: Hong
authors: Rong-hua
authors: RH
authors: Chen
authors: Mei-ling
authors: ML
authors: Tong
authors: Min
authors: M
authors: Zhang
authors: Li
authors: L
authors: Fei
authors: Xiao-qin
authors: XQ
authors: Pan
authors: Mei
authors: M
authors: Guo
authors: Xi-rong
authors: XR
authors: Guo
authors: Xia
authors: X
authors: Chi
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D017397:Prefrontal Cortex / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D020133:Reverse Transcriptase Polymerase Chain Reaction