Opioid agonist pharmacotherapy in New South Wales from 1985 to 2006: patient characteristics and patterns and predictors of treatment retention.
OBJECTIVE
The aims of this study were to: examine the number and characteristics of patients entering and re-entering opioid replacement treatment between 1985 and 2006, to examine select demographic and treatment correlates of leaving treatment between 1985 and 2000, and to compare retention rates in methadone and buprenorphine maintenance treatment from 2001 to 2006.


METHODS
A retrospective cohort study using register data from the Pharmaceutical Drugs of Addiction System.


METHODS
Opioid substitution treatment in New South Wales (NSW), Australia.


METHODS
A total of n = 42 690 individuals prescribed opioid replacement treatment between 1985 and 2006 in NSW.


METHODS
Client characteristics over time, retention in days in first treatment episode, number of episodes of treatment and proportion switching medication.


RESULTS
Overall, younger individuals were significantly more likely to leave their first treatment episode than older individuals. In 2001-06, after controlling for age, sex and first administration point, the hazard of leaving treatment was 1.9 times for those on buprenorphine relative to those on methadone. Retention in treatment varied somewhat across historical time, with those entering during 1995-2000 more likely to leave at an earlier stage than those who entered before that time.


CONCLUSIONS
Retention in treatment appears to fluctuate in inverse proportion to the availability of heroin. Individuals in contemporary treatment are older users with a lengthy treatment history. This study has provided population-level evidence to suggest that retention in methadone and buprenorphine differ in routine clinical practice. Future work might investigate ways in which patient adherence and retention may be improved.
Burns
Lucy
L
National Drug and Alcohol Research Centre, University of New South Wales, Sydney. l.burns@unsw.edu.au
Randall
Deborah
D
Hall
Wayne D
WD
Law
Matthew
M
Butler
Tony
T
Bell
James
J
Degenhardt
Louisa
L
D000328:Adult; D002047:Buprenorphine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009292:Narcotic Antagonists / Q000627:therapeutic use; D009517:New South Wales; D009293:Opioid-Related Disorders / Q000188:drug therapy / Q000534:rehabilitation*; D010818:Practice Patterns, Physicians'; D012189:Retrospective Studies; D055815:Young Adult
D009292:Narcotic Antagonists; D002047:Buprenorphine