title: The myeloperoxidase gene and its influence on myocardial infarction in a Swedish population: protective role of the -129A allele in women.
abstract: OBJECTIVE
  The aim of this study is to investigate the potential role of functional myeloperoxidase (MPO) promoter polymorphisms in the occurrence of myocardial infarction (MI) in the Stockholm Heart Epidemiology Program.
  
  
  RESULTS
  Two MPO promoter polymorphisms, -129G/A and -463G/A, were genotyped in the Stockholm Heart Epidemiology Program population (n = 2774). The -129A allele was associated with a lower risk of MI in women [odds ratio (OR) (95% confidence interval): 0.65 (0.43-0.98), P = 0.03] but not in men [OR: 1.12 (0.86-1.47), P = 0.38]. When women were stratified by age and hormone replacement therapy, the protective effect of the -129A allele was only evident in women younger than 55 years or not receiving hormone replacement therapy. In these two groups, OR (95% confidence interval) for carriers of the -129A allele were 0.34 (0.12-0.92) (P = 0.03) and 0.51 (0.32-0.81) (P = 0.004), respectively. For the -463G/A polymorphism, no associations to MI risk were observed either in women or in men.
  
  
  CONCLUSIONS
  The A allele of the MPO -129G/A promoter polymorphism is associated with a reduced MI risk in women.
authors: of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm S-171 77, Sweden.
authors: Elena
authors: E
authors: Zotova
authors: Louise
authors: L
authors: Lyrenäs
authors: Ulf
authors: U
authors: de Faire
authors: Ralf
authors: R
authors: Morgenstern
authors: Bruna
authors: B
authors: Gigante
authors: Anna M
authors: AM
authors: Bennet
mesh_terms: D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D016017:Odds Ratio; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology; D016387:Women's Health
chemical_list: D009195:Peroxidase