title: Interval of injections of intramuscular depot medroxyprogesterone acetate in the long-term treatment of endometriosis-associated pain: a randomized comparative trial.
abstract: OBJECTIVE
  To determine the optimal interval of injections of intramuscular depot medroxyprogesterone acetate 150 mg in the long-term treatment of endometriosis-associated pain.
  
  
  METHODS
  112 patients with symptomatic endometriosis were randomized to receive either injections every month for 6 months, then every 3 months for a total of 15 months or injections every 3 months for 15 months. The primary outcome measure was patients' satisfaction.
  
  
  RESULTS
  At months 3, 6, 9, 12 and 15 of the treatment phase, there was no statistically significant difference of percentages of patients with satisfaction between the two regimens (85.7 vs. 76.8%, 76.8 vs. 73.2%, 66.1 vs. 58.9%, 60.7 vs. 55.4%, 60.7 vs. 55.4%, respectively).
  
  
  CONCLUSIONS
  The optimal interval of injections of depot medroxyprogesterone acetate 150 mg is every 3 months.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla 90110 Thailand. csophon@medicine.psu.ac.th
authors: Sopon
authors: S
authors: Cheewadhanaraks
authors: Krantarat
authors: K
authors: Peeyananjarassri
authors: Chainarong
authors: C
authors: Choksuchat
authors: Kriengsak
authors: K
authors: Dhanaworavibul
authors: Thanapan
authors: T
authors: Choobun
authors: Sathana
authors: S
authors: Bunyapipat
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D004715:Endometriosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D017060:Patient Satisfaction; D018579:Patient Selection; D017697:Premenopause; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D017258:Medroxyprogesterone Acetate