title: Chirality-dependent hydrogen bond direction in jet-cooled (S)-1,2,3,4-tetrahydro-3-isoquinoline methanol (THIQM): IR-ion dip vibrational spectroscopy of the neutral and the ion.
abstract: The structural modifications of (S)-1,2,3,4-tetrahydro-3-isoquinoline methanol (THIQM) upon ionisation have been investigated in jet-cooled conditions, by means of laser-induced fluorescence, REMPI, and IR-UV ion-dip spectroscopy of the neutral ground state and the ion. These results combined with ab initio calculations, support the presence in the jet of two low-energy conformers of THIQM. In the most stable Conformer I, the CH(2)OH substituent acts as a hydrogen bond donor to the nitrogen lone pair in the equatorial position. In this case, the nitrogen atom is in (S) configuration. Conformer II shows the opposite NHO hydrogen bond from the hydrogen atom in the equatorial position of nitrogen to the OH group. In this case, the nitrogen atom is in (R) configuration. This chirality dependence of the hydrogen bond direction is lost upon ionisation. While ionisation of Conformer II reinforces the NHO hydrogen bond, ionisation of Conformer I induces its isomerisation to the same ion as Conformer II, i.e. a change in hydrogen bond direction.
authors: CNRS, Laboratoire de Photophysique Moléculaire, UPR, Orsay, France.
authors: Ahmed
authors: A
authors: Mahjoub
authors: Amrita
authors: A
authors: Chakraborty
authors: Valeria
authors: V
authors: Lepere
authors: Katia
authors: K
authors: Le Barbu-Debus
authors: Nikhil
authors: N
authors: Guchhait
authors: Anne
authors: A
authors: Zehnacker
mesh_terms: D006860:Hydrogen Bonding; D013058:Mass Spectrometry; D000432:Methanol / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011789:Quantum Theory; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000737:chemistry*; D014732:Vibration
chemical_list: D044005:Tetrahydroisoquinolines; D000432:Methanol