title: Pancytopenia with hypercellular bone marrow secondary to cytomegalovirus after cardiac transplant.
abstract: We describe a case of cytomegalovirus-induced pancytopenia in a heart transplant patient. The interesting finding of a hypercellular bone marrow indicates the possibility of a different mechanism for the pancytopenia other than bone marrow suppression. The patient was treated with ganciclovir, which resulted in the complete resolution of the viremia and pancytopenia. Cytomegalovirus infection should be suspected in heart transplant patients with pancytopenia, regardless of bone marrow results. The pathogenesis of cytomegalovirus-induced pancytopenia is likely multifactorial, with both a central and peripheral effect.
authors: Division of Cardiology, Dalhousie University, Halifax, Nova Scotia.
authors: Osama
authors: O
authors: Elkhateeb
authors: Simon
authors: S
authors: Jackson
authors: Walter F
authors: WF
authors: Schlech
authors: Kate
authors: K
authors: Storm
authors: Jonathan
authors: J
authors: Howlett
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D015774:Ganciclovir / Q000627:therapeutic use; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009894:Opportunistic Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D010198:Pancytopenia / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D015774:Ganciclovir