title: Assessment of thalamic perfusion in patients with mild traumatic brain injury by true FISP arterial spin labelling MR imaging at 3T.
abstract: OBJECTIVE
  To assess cerebral blood flow (CBF) changes in patients with mild traumatic brain injury (MTBI) using an arterial spin labelling (ASL) perfusion MRI and to investigate the severity of neuropsychological functional impairment with respect to haemodynamic changes.
  
  
  METHODS
  Twenty-one patients with MTBI and 20 healthy controls were studied at 3T MR. The median time since the onset of brain injury in patients was 24.6 months. Both patients and controls underwent a traditional consensus battery of neurocognitive tests. ASL was performed using true fast imaging with steady state precession and a flow-sensitive alternating inversion recovery preparation. Regional CBF were measured in both deep and cortical gray matter as well as white matter at the level of basal ganglia.
  
  
  RESULTS
  The mean regional CBF was significantly lower in patients with MTBI (45.9 +/- 9.8 ml/100 g min(-1)) as compared to normal controls (57.1 +/- 8.1 ml/100 g min(-1); p = 0.002) in both sides of thalamus. The decrease of thalamic CBF was significantly correlated with several neurocognitive measures including processing and response speed, memory/learning, verbal fluency and executive function in patients.
  
  
  CONCLUSIONS
  Haemodynamic impairment can occur and persist in patients with MTBI, the extent of which is more severe in thalamic regions and correlate with neurocognitive dysfunction during the extended course of disease.
authors: Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York 10016, USA. yulin.ge@med.nyu.edu
authors: Yulin
authors: Y
authors: Ge
authors: Mayur B
authors: MB
authors: Patel
authors: Qun
authors: Q
authors: Chen
authors: Elan J
authors: EJ
authors: Grossman
authors: Ke
authors: K
authors: Zhang
authors: Laura
authors: L
authors: Miles
authors: James S
authors: JS
authors: Babb
authors: Joseph
authors: J
authors: Reaume
authors: Robert I
authors: RI
authors: Grossman
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D013113:Spin Labels; D013788:Thalamus / Q000098:blood supply*; D055815:Young Adult
chemical_list: D013113:Spin Labels