Gene expression profiles in the prefrontal cortex of SHR rats by cDNA microarrays.
We have undertaken cDNA microarrays to identify differentially expressed genes in the prefrontal cortex (PFC) of spontaneously hypertensive-rat (SHR), a rodent model of attention deficit hyperactivity disorder (ADHD) versus control Wistar-Kyoto (WKY) rats. The analysis of the gene expression profiles indicated that 57 genes were up-regulated and 97 genes were down-regulated in the PFC of SHR. These predominately expressed genes included genes involved in neural development, immunity, transcription factor, monoamine neurotransmitter, metabolism, signal transduction, apoptosis and so on. Although more detailed analyses are necessary, it is anticipated that further study of genes identified will provide insights into their specific roles in the etiology of ADHD.
Qiu
Jie
J
Department of Pediatrics, Nanjing Maternity and Child Health Hospital of Nanjing Medical University, 210004, Nanjing, China. jieqiu@yahoo.cn
Hong
Qin
Q
Chen
Rong-hua
RH
Tong
Mei-ling
ML
Zhang
Min
M
Fei
Li
L
Pan
Xiao-qin
XQ
Guo
Mei
M
Guo
Xi-rong
XR
Chi
Xia
X
D000818:Animals; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D017397:Prefrontal Cortex / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D020133:Reverse Transcriptase Polymerase Chain Reaction