CALHM1 variant is not associated with Alzheimer's disease among Asians.
In a case control study involving 484 study subjects, we showed that the CALHM1 allele (13.5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls. Logistic regression analysis did not reveal any interaction between ApoE4 allele and CALHM1 allele.
Tan
E K
EK
Department of Neurology, Clinical Research and Health Screening, Singapore General Hospital, Outram Road, 169608 Singapore, Singapore. gnrtek@sgh.com.sg
Ho
P
P
Cheng
S Y
SY
Yih
Yuen
Y
Li
H H
HH
Fook-Chong
S
S
Lee
W L
WL
Zhao
Yi
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D001208:Asia / Q000453:epidemiology / Q000208:ethnology; D015220:Calcium Channels / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D053327:Apolipoprotein E4; C530077:CALHM1 protein, human; D015220:Calcium Channels; D008562:Membrane Glycoproteins