title: Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
abstract: The transcription factor nuclear factor kappaB (NF-kappaB) induces the expression of various inflammatory genes. In the common NF-kappaB signaling pathway, peperomin E and 2,6-didehydropeperomin B inhibited IkappaB degradation upon stimulation with TNF-alpha or interleukin-1. Consistent with these results, peperomin E and 2,6-didehydropeperomin B blocked the TNF-alpha-induced activation of IkappaB kinase, while they had no direct effect on the IkappaB kinase activity. Our present results clearly demonstrate that peperomins inhibit the NF-kappaB signaling pathway by blocking IkappaB kinase activation.
authors: Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
authors: Chieko
authors: C
authors: Tsutsui
authors: Yuriko
authors: Y
authors: Yamada
authors: Masayoshi
authors: M
authors: Ando
authors: Daisuke
authors: D
authors: Toyama
authors: Jian-Lin
authors: JL
authors: Wu
authors: Liyan
authors: L
authors: Wang
authors: Shigeru
authors: S
authors: Taketani
authors: Takao
authors: T
authors: Kataoka
mesh_terms: D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D052117:Benzodioxoles / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007375:Interleukin-1 / Q000378:metabolism; D008956:Models, Chemical; D016328:NF-kappa B / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C545362:2,6-didehydropeperomin B; D000893:Anti-Inflammatory Agents; D052117:Benzodioxoles; D007375:Interleukin-1; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; C545363:peperomin E