title: [Cyclin D1 gene G870A polymorphism and susceptibility to nasopharyngeal carcinoma].
abstract: OBJECTIVE
  The aim of this study was to investigate the susceptibility and prognostic implications of the cyclin D1 gene (CCND1) G870A polymorphism to nasopharyngeal carcinomas (NPC) in Han population in Yunnan China.
  
  
  METHODS
  Two hundred and forty one cases with NPC and 271 matched cancer-free controls were genotyped for the CCND1 G870A polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing. The adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by using unconditional logistic regression model. Overall survival was assessed using univariate and multivariate analyses.
  
  
  RESULTS
  Contrast with homozygous CCND1 G870G, A allele significantly increasing risk of NPC was associated with homozygous A870A (OR = 4.79, 95% CI 2.77 - 8.28, P < 0.001) and heterozygous A870G (OR = 1.72, 95% CI 1.10 - 2.68, P = 0.017). The subjects at least having one CCND1 870A allele had OR of 2.40 (95% CI 1.59 - 3.63, P < 0.001). Furthermore, smoking may increase the risk of developing NPC interacting with CCND1 G870A polymorphism. Kaplan-Meier analysis and Cox regression analysis demonstrated that the five-year survival rate of subjects with AA, AG and GG genotype was 56.2%, 78.5% and 81.4% (AA vs GG, P = 0.003; AA vs AG, P = 0.012; AG vs GG, P = 0.132), but not independent prognostic factor in NPC (P = 0.501).
  
  
  CONCLUSIONS
  The CCND1 870A allele is associated with the NPC in Han population in Yunnan China, meanwhile, showed a significant prognosis for those patients.
authors: Department of Head and Neck Surgery, Third Hospital Affiliated Kunming Medical University, Yunnan Cancer Reaserch Center, Kunming 650118, China.
authors: Jun
authors: J
authors: Sui
authors: Wei
authors: W
authors: Gao
authors: Xiao-jiang
authors: XJ
authors: Li
authors: Jing
authors: J
authors: Ma
authors: Yan-xin
authors: YX
authors: Ren
authors: Xin
authors: X
authors: Song
authors: Chun-jie
authors: CJ
authors: Xiao
authors: Wen-ru
authors: WR
authors: Tang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D055815:Young Adult
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1