[Research advance on application of platelet-rich plasma in wound repair -- review].
Platelets (Plts) have been shown to play a critical role in tissue repair mechanisms such as chemotaxis, cell proliferation, angiogenesis and extracellular matrix deposition. These effects are largely due to the contents of platelet granules, among which there are a number of important growth factors contributing to the wound repairing process. Platelet-rich plasma (PRP) has been traditionally used as a source of platelet growth factors (PGFs). After connecting activator, platelet gel (PG) is formed and numerous PGFs such as PDGF, TGF, VEGF, IGF, and EGF are released. It is important in different stages of the wound-healing cascade and greatly influence mitogenic and cellular differentiation activities. The aim of this review is to present knowledge about properties of PRP and possibilities of using PRP in the treatment of wound, as well as the success of the clinical studies performed so far, finally the future of PRP therapies are also described.
Gao
Feng
F
Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Wang
Jie-Xi
JX
Han
Ying
Y
D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D053657:Platelet-Rich Plasma; D014945:Wound Healing
D036341:Intercellular Signaling Peptides and Proteins; D010982:Platelet-Derived Growth Factor