Adaptations in the glucose metabolism of procyclic Trypanosoma brucei isolates from tsetse flies and during differentiation of bloodstream forms.
Procyclic forms of Trypanosoma brucei isolated from the midguts of infected tsetse flies, or freshly transformed from a strain that is close to field isolates, do not use a complete Krebs cycle. Furthermore, short stumpy bloodstream forms produce acetate and are apparently metabolically preadapted to adequate functioning in the tsetse fly.
van Grinsven
Koen W A
KW
Department of Biochemistry and Cell Biology, Utrecht University, The Netherlands.
Van Den Abbeele
Jan
J
Van den Bossche
Peter
P
van Hellemond
Jaap J
JJ
Tielens
Aloysius G M
AG
D000818:Animals; D001769:Blood / Q000469:parasitology; D002454:Cell Differentiation; D002952:Citric Acid Cycle; D005947:Glucose / Q000378:metabolism*; D007422:Intestines / Q000469:parasitology; D008018:Life Cycle Stages; D014346:Trypanosoma brucei brucei / Q000166:cytology / Q000254:growth & development* / Q000302:isolation & purification / Q000378:metabolism*; D014370:Tsetse Flies / Q000469:parasitology*
D005947:Glucose