Closing in on mechanisms of tissue morphogenesis.
It remains largely unknown how large-scale tissue movements during development emerge from the interplay of different tensile forces associated with actomyosin networks. Solon et al. (2009) now report that a ratchet-like mechanism drives the movement of epithelial sheets during dorsal closure in embryos of the fruit fly Drosophila.
Rauzi
Matteo
M
IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy case 907, 13288 Marseille Cedex 09, France.
Lecuit
Thomas
T
D000818:Animals; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology*; D004475:Ectoderm / Q000166:cytology / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000378:metabolism