[Correlation of mycophenolic acid pharmacokinetic parameters with clinical events in kidney transplant patients treated with mycophenolate mofetil].
OBJECTIVE
To investigate the correlation of pharmacokinetic profiles of mycophenolic acid (MPA) with clinic events in kidney transplant patients treated with mycophenolate mofetil (MMF).


METHODS
Sixty-four kidney transplant patients were treated with the triple immune suppression protocol with cyclosporine, MMF, and prednisone. Before the administration of drugs, and 0.5, 1, 1.5, 2, 2.5, 4, 6, 8, 10, and 12 hours after the drug administration peripheral blood samples were collected to detect the plasma MPA concentrations (MPA-C(0)) and draw the concentration-time curve. And 4, 7, 21, and 28 days, and 1.5, 2, 3, and 6 months later peripheral blood samples were collected in the morning before drug administration so as to dynamically measure the plasma MPA concentrations. Clinical events were observed.


RESULTS
No side effect or acute rejection episode occurred with the median MPA-C(0) value of 0.74 mg/L. Side effects occurred with the median MPA-C(0) value of 1.32 mg/L. Sixteen case-times demonstrated acute rejection episode with the median MPA-C(0) value of 0.39 mg/L. The incidence rates of different side effects, such as infection, bone marrow depression, and digestive tract symptoms were significantly related to MPA-C(0) dose-dependently.


CONCLUSIONS
MPA-C(0) may be an appropriate pharmacokinetic monitoring parameter for kidney transplant.
Lin
Bo
B
Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhu
Yu-chun
YC
Lu
Yi-ping
YP
D000293:Adolescent; D000328:Adult; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D055815:Young Adult
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid