title: ACP1 genotype, glutathione reductase activity, and riboflavin uptake affect cardiovascular risk in the obese.
abstract: Erythrocyte acid phosphatase (ACP locus 1), also known as low-molecular-weight protein tyrosine phosphatase, has previously been associated to glycemia, dyslipidemia, and obesity. In this study, ACP1 genotype and activity were tested in 318 women aged 19 to 83 (mean, 51.74 +/- 13.44) years. ACP1 genotype was found to directly correlate to glutathione reductase activity (P < .001) and levels of low-density lipoprotein cholesterol (P = .038). Glutathione reductase activity was in turn found to correlate to a series of cardiovascular risk factors such as systolic arterial pressure (P < .001), total cholesterol levels (P = .018), and low-density lipoprotein cholesterol levels (P = .039). A possible protective effect of ACP1 genotype AA against these cardiovascular risk factors was observed in this study. Furthermore, this work hypothesizes that nutritional riboflavin uptake becomes more crucial as body mass index increases, to counteract oxidative stress and minimize cardiovascular risk. This might be especially true in ACP1 genotypes AC, BC, and CC, which might possibly show the least endogenous protection against oxidative stress.
authors: Laboratório de Genética e Centro de Metabolismo e Endocrinologia, FML, Genetic Laboratory and Centre for Metabolism and Endocrinology, Medical Faculty, Lisbon University, Portugal. ink_2010@hotmail.com
authors: Nadja
authors: N
authors: Apelt
authors: Alda Pereira
authors: AP
authors: da Silva
authors: Joana
authors: J
authors: Ferreira
authors: Irina
authors: I
authors: Alho
authors: Cristina
authors: C
authors: Monteiro
authors: Cláudia
authors: C
authors: Marinho
authors: Pedro
authors: P
authors: Teixeira
authors: Luís
authors: L
authors: Sardinha
authors: Ma José
authors: MJ
authors: Laires
authors: Mário Rui
authors: MR
authors: Mascarenhas
authors: Manuel Pires
authors: MP
authors: Bicho
mesh_terms: D000135:Acid Phosphatase / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005838:Genotype; D005980:Glutathione Reductase / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012256:Riboflavin / Q000378:metabolism*; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D011518:Proto-Oncogene Proteins; D005980:Glutathione Reductase; D000135:Acid Phosphatase; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases; D012256:Riboflavin