title: Isolation, biomimetic synthesis, and cytotoxic activity of bis(pseudopterane) amines.
abstract: LC-MS/MS-based screening of the dichloromethane extract of the gorgonian coral Pseudopterogorgia acerosa led to the isolation of a novel bis(pseudopterane) amine (1). The structural assignment of 1 was achieved by 1D and 2D NMR and mass spectrometry analysis. A biomimetic synthesis of 1 and the known symmetrical diterpene 2 from pseudopterolide (3) is described in this report. Bis(pseudopterane) amine showed selective growth inhibition activity against cancer cell lines with IC(50) values of 4.2 microM (HCT116) and 42 microM (HeLa).
authors: Department of Chemistry, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
authors: Abhijeet S
authors: AS
authors: Kate
authors: Jason K
authors: JK
authors: Pearson
authors: Balaji
authors: B
authors: Ramanathan
authors: Kelly
authors: K
authors: Richard
authors: Russell G
authors: RG
authors: Kerr
mesh_terms: D000588:Amines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000588:Amines; D000970:Antineoplastic Agents; D004224:Diterpenes