[In vitro inhibitory mechanism of respiratory syncytial virus with solution prescription of zhidanhuayu].
OBJECTIVE
To study the effective part of solution prescription of Zhidanhuayu (ZDHY) against respiratory syncytial virus (RSV) in vitro.


METHODS
Observe the pathology of RSV to Hep-2 under the condition of different concentrations and each effective part of ZDHY.


RESULTS
The concentration limit causing celluar toxicity of ZDHY is 5.5 mg/ml. The ZDHY failed to block the absorption of RSV to Hep-2 within this concentration, and consequently the cell fell into the full pathological changes. During the concentration of 2.75-5.50 mg/ml, the ZDHY directly destroyed virus array,meanwhile, the infected cells that treated by the medicine kept healthy also.


CONCLUSIONS
ZDHY could not defend the infection of RSV, but is able to destroy the RSV directly and inhibit the RSV inhabiting in the cell.
Liu
Yu-hua
YH
Department of Pediatrics, Beijing Friendship Hospital Affiliate of Capital University of Medical Sciences, Beijing 100050, China.
Hou
An-cun
AC
Zhao
Gao-chao
GC
D000818:Animals; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002460:Cell Line; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000627:therapeutic use; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000502:physiology; D014709:Vero Cells / Q000187:drug effects / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal