title: Introduction to proteomics.
abstract: In this chapter, the evolvement of proteomics from classical protein chemistry is depicted. The challenges of complexity and dynamics led to several new approaches and to the firm belief that a valuable proteomics technique has to be quantitative. Protein-based vs. peptide-based techniques, gel-based vs. non-gel-based proteomics, targeted vs. general proteomics, isotopic labeling vs. label-free techniques, and the importance of informatics are summarized and compared. A short outlook into the near future is given at the end of the chapter.
authors: Protein Analytics, Max-Planck-Institute of Biochemistry, Martinsried, Germany.
authors: Friedrich
authors: F
authors: Lottspeich
mesh_terms: D019295:Computational Biology; D010446:Peptide Fragments / Q000032:analysis*; D011506:Proteins / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*
chemical_list: D010446:Peptide Fragments; D011506:Proteins