The significance of EMAP-II after allogeneic stem cell transplantation.
Endothelial monocyte-activating polypeptide-II (EMAP-II) appears to play an important role in neovascularization and endothelial abnormalities. However, the role of EMAP-II in development of graft-versus-host disease (GVHD) after allogeneic SCT is poorly understood. We measured and compared the levels of EMAP-II, cytokines, and soluble factors in patients undergoing allogeneic SCT. The subjects were 23 patients who underwent allogeneic SCT. Most of the cytokines/soluble factors exhibited a significant elevation after allogeneic SCT, although Angiopoietin-1 did not change. On the other hand, the levels of these factors did not change significantly in the recipients of autologous SCT. When the relationship between EMAP-II and cytokines/soluble factors was analyzed, EMAP-II levels correlated positively with sIL-2R, sVCAM-1, sE-selectin, sFasL and EDMP. However, IL-6, Angiopoietin-1, Angiopoietin-2 and VEGF were not correlated with EMAP-II. Our results suggest that EMAP-II plays an important role in endothelial cell dysfunction related to GVHD after allogeneic SCT.
Nomura
Shosaku
S
Division of Hematology, Kishiwada City Hospital, Kishiwada, Osaka, Japan. shosaku-n@mbp.ocn.ne.jp
Ishii
Kazuyoshi
K
Shimizu
Michiomi
M
Inami
Norihito
N
Uoshima
Nobuhiko
N
Urase
Fumiaki
F
Maeda
Yasuhiro
Y
Hayashi
Kunio
K
D000328:Adult; D000368:Aged; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous
D016207:Cytokines; D009363:Neoplasm Proteins; D016601:RNA-Binding Proteins; C077219:small inducible cytokine subfamily E, member 1