title: In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography.
abstract: We interrogate the ability of free-space fluorescence tomography to image small animals in vivo using charge-coupled device (CCD) camera measurements over 360-deg noncontact projections. We demonstrate the performance of normalized dual-wavelength measurements that are essential for in-vivo use, as they account for the heterogeneous distribution of photons in tissue. In-vivo imaging is then showcased on mouse lung and brain tumors cross-validated by x-ray microcomputed tomography and histology.
authors: Nikolaos C
authors: NC
authors: Deliolanis
authors: Joshua
authors: J
authors: Dunham
authors: Thomas
authors: T
authors: Wurdinger
authors: Jose-Luiz
authors: JL
authors: Figueiredo
authors: Bakhos A
authors: BA
authors: Tannous
authors: Tannous
authors: T
authors: Bakhos
authors: Vasilis
authors: V
authors: Ntziachristos
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005453:Fluorescence; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D051379:Mice; D015203:Reproducibility of Results; D014054:Tomography / Q000379:methods*; D055114:X-Ray Microtomography