Polyhydroxyalkanoates: materials for delivery systems.
An overview of polyhydroxyalkanoates as biodegradable and biocompatible materials for the development of drug delivery systems is presented. Polymers currently used for medical applications are compared with polyhydroxyalkanoates. The biochemical and physical properties of polyhydroxyalkanoates, including their biosynthesis, are discussed. Previous delivery systems based on polyhydroxyalkanoates are reviewed and specific examples from anticancer drugs, antiviral drugs, and contraceptives are highlighted. While polyhydroxyalkanoates have not been extensively studied for their potential use as drug delivery materials, several advantages and limitations are apparent.
Nobes
G A
GA
Department of Chemistry, McGill University, Montreal, Canada.
Marchessault
R H
RH
Maysinger
D
D