title: Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification.
abstract: The synthesis and SAR of a new series of potent and selective dopamine D(3) receptor antagonists is reported.
authors: Cancer Therapeutics, Melbourne, Australia.
authors: Ian P
authors: IP
authors: Holmes
authors: Fabrizio
authors: F
authors: Micheli
authors: Simon
authors: S
authors: Gaines
authors: Olivier
authors: O
authors: Lorthioir
authors: Steve P
authors: SP
authors: Watson
authors: Romano Di
authors: RD
authors: Fabio
authors: Gabriella
authors: G
authors: Gentile
authors: Christian
authors: C
authors: Heidbreder
authors: Chiara
authors: C
authors: Savoia
authors: Angela
authors: A
authors: Worby
mesh_terms: D000818:Animals; D002415:Cats; D051638:Ether-A-Go-Go Potassium Channels / Q000378:metabolism; D006801:Humans; D048289:Imidazolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008024:Ligands; D049268:Positron-Emission Tomography; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D051638:Ether-A-Go-Go Potassium Channels; D048289:Imidazolidines; C496884:KCNH1 protein, human; D008024:Ligands; D050637:Receptors, Dopamine D3