title: [Effects of antimicrobial drugs on soil microbial respiration].
abstract: The effects on soil microbial respiration of sulfonamides, tetracyclines, macrolides and so on were studied using the direct absorption method. The results show sulfamethazine, sulfamethoxazole, chlortetracycline, tetracycline, tylosin and trimethoprim inhibit soil respiration 34.33%, 34.43%, 2.71%, 3.08%, 7.13%, 38.08% respectively. Sulfamethoxazole and trimethoprim have the highest inhibition rates among all the antibiotics. In early incubation period (0-2 d), the concentrations above 10 mg x kg(-1) of sulfamethazine, sulfamethoxazole and trimethoprim remarkably decrease soil CO2 emission. The effects of these antibiotics vary with their concentrations too. Sulfamethoxazole and trimethoprim show good dose-response relationships. According to the standard of pesticide safety evaluation protocol, the six antibiotics pose a little risk to soil microbial environment.
authors: State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China. liufeng10@126.com
authors: Feng
authors: F
authors: Liu
authors: Guang-Guo
authors: GG
authors: Ying
authors: Qi-Xing
authors: QX
authors: Zhou
authors: Ran
authors: R
authors: Tao
authors: Hao-Chang
authors: HC
authors: Su
authors: Xu
authors: X
authors: Li
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000378:metabolism*; D018407:Bacterial Physiological Phenomena / Q000187:drug effects; D019069:Cell Respiration / Q000187:drug effects; D004784:Environmental Monitoring; D012987:Soil / Q000032:analysis*; D012988:Soil Microbiology; D012989:Soil Pollutants / Q000032:analysis* / Q000494:pharmacology; D013411:Sulfadiazine / Q000032:analysis / Q000494:pharmacology; D013412:Sulfadimethoxine / Q000032:analysis / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D012987:Soil; D012989:Soil Pollutants; D013411:Sulfadiazine; D013412:Sulfadimethoxine