title: [Hepatobiliary transport of glutathione and its role in cholestasis].
abstract: Glutathione is a tripeptide comprised by L-glutamate, L-cysteine, and glycine, that serves antioxygenation and deintoxication functions within the cell. Recent study has found that glutathione is the main driving force for bile salt-independent bile flow, impaired biliary excretion of glutathione can lead to cholestasis. This review focuses on hepatobiliary transport of glutathione and its role in cholestasis. Based on the evidence of choleretic effect of glutathione, enhancement of biliary excretion of glutathione may be a good strategy for prevention and treatment of cholestasis.
authors: Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
authors: Xue-ying
authors: XY
authors: Zhang
authors: Jin
authors: J
authors: Yang
authors: Xue-fen
authors: XF
authors: Yin
authors: Xiao-dong
authors: XD
authors: Liu
authors: Guang-ji
authors: GJ
authors: Wang
mesh_terms: D000818:Animals; D001692:Biological Transport; D002779:Cholestasis / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D004967:Estrogens / Q000009:adverse effects; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D007566:Jaundice, Chronic Idiopathic / Q000235:genetics*; D008099:Liver / Q000378:metabolism*; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D010590:Phalloidine / Q000009:adverse effects; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D004967:Estrogens; D005978:Glutathione; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010590:Phalloidine; D014580:Ursodeoxycholic Acid