title: Renal venous thrombosis in a newborn with prothrombotic risk factors.
abstract: Renal venous thrombosis (RVT) is a rare but a well recognized entity in children and neonates. The clinical signs of neonatal RVT include hypertension, enlarged kidney(s), hematuria, renal insufficiency, proteinuria, thrombocytopenia, or all. Persisting impairment of kidney function and hypertension are serious and common complications in patients with RVT. Risk factors for the development of RVT include maternal diabetes mellitus, pathologic states associated with thrombosis (e.g., shock, dehydration, perinatal asphyxia, polycythemia), and sepsis. Inherited prothrombotic abnormalities have been described in some reports of RVT. We report the case of a male newborn with left RVT and associated homozygosity for both factor V Leiden (G1691A) and methylenetetrahydrofolate reductase C677T mutations in addition to elevated serum lipoprotein (a). The patient was treated with heparin. We believe our case to be the first reported case in the English medical literature of such an association between neonatal RVT and homozygosity for both factor V Leiden and methylenetetrahydrofolate reductase. This case and other studies clearly demonstrate that neonatal RVT should be evaluated for thrombophilia conditions.
authors: Division of Hematology/Oncology, American University of Beirut Medical Center, Beirut, Lebanon. sm03@aub.edu.lb
authors: Samar A
authors: SA
authors: Muwakkit
authors: Raya
authors: R
authors: Saab
authors: Sami A
authors: SA
authors: Sanjad
authors: Saleh I
authors: SI
authors: Bhar
authors: Rim S
authors: RS
authors: Ishak
authors: Zeina A
authors: ZA
authors: Samad
authors: Anthony K
authors: AK
authors: Chan
authors: Miguel R
authors: MR
authors: Abboud
mesh_terms: D020016:Activated Protein C Resistance / Q000150:complications* / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D005838:Genotype; D006417:Hematuria / Q000151:congenital / Q000209:etiology; D006493:Heparin / Q000627:therapeutic use; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020125:Mutation, Missense; D017354:Point Mutation; D012082:Renal Veins / Q000000981:diagnostic imaging; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications / Q000151:congenital* / Q000235:genetics; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*
chemical_list: D017270:Lipoprotein(a); C095381:factor V Leiden; D005165:Factor V; D006493:Heparin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)