title: Bayesian multi-modal model comparison: a case study on the generators of the spike and the wave in generalized spike-wave complexes.
abstract: We present a novel approach to assess the networks involved in the generation of spontaneous pathological brain activity based on multi-modal imaging data. We propose to use probabilistic fMRI-constrained EEG source reconstruction as a complement to EEG-correlated fMRI analysis to disambiguate between networks that co-occur at the fMRI time resolution. The method is based on Bayesian model comparison, where the different models correspond to different combinations of fMRI-activated (or deactivated) cortical clusters. By computing the model evidence (or marginal likelihood) of each and every candidate source space partition, we can infer the most probable set of fMRI regions that has generated a given EEG scalp data window. We illustrate the method using EEG-correlated fMRI data acquired in a patient with ictal generalized spike-wave (GSW) discharges, to examine whether different networks are involved in the generation of the spike and the wave components, respectively. To this effect, we compared a family of 128 EEG source models, based on the combinations of seven regions haemodynamically involved (deactivated) during a prolonged ictal GSW discharge, namely: bilateral precuneus, bilateral medial frontal gyrus, bilateral middle temporal gyrus, and right cuneus. Bayesian model comparison has revealed the most likely model associated with the spike component to consist of a prefrontal region and bilateral temporal-parietal regions and the most likely model associated with the wave component to comprise the same temporal-parietal regions only. The result supports the hypothesis of different neurophysiological mechanisms underlying the generation of the spike versus wave components of GSW discharges.
authors: Institute of Neurology, Wellcome Trust Centre for Neuroimaging, University College of London, 12 Queen Square, London, UK. j.daunizeau@fil.ion.ucl.ac.uk
authors: Jean
authors: J
authors: Daunizeau
authors: Anna E
authors: AE
authors: Vaudano
authors: Louis
authors: L
authors: Lemieux
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D002540:Cerebral Cortex / Q000473:pathology; D002560:Cerebrovascular Circulation; D004569:Electroencephalography / Q000706:statistics & numerical data*; D004832:Epilepsy, Absence / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D015233:Models, Statistical; D009010:Monte Carlo Method; D010100:Oxygen / Q000097:blood; D055815:Young Adult
chemical_list: D010100:Oxygen