The effect of quantum dots on synaptic transmission and plasticity in the hippocampal dentate gyrus area of anesthetized rats.
Recently, quantum dots (QDs) have attracted widespread interest in biology and medicine. They are rapidly being used as new tools for both diagnostic and therapeutic purposes. Critical issues for further applications of QDs include the assessment of biocompatibility and biosafety of QDs. Most of previous researches concerning QD cytotoxicity focused on in vitro studies. In the present study, the impairments of acute exposure to well-modified and unmodified QDs (streptavidin-CdSe/ZnS and CdSe QDs, respectively) on synaptic transmission and plasticity were examined in adult rat hippocampal dentate gyrus (DG) area in vivo. The input/output (I/O) functions, paired-pulse ratio (PPR), field excitatory postsynaptic potential (fEPSP) and population spike (PS) amplitude were measured. The results showed that PPR and long-term potentiation (LTP) were all significantly decreased in these two types of QD-exposed rats compared to those in control rats. While the I/O functions and the amplitudes of fEPSP slope and PS amplitude of the baseline were significantly increased under QD exposure. These findings suggest that exposure to QDs, no matter whether they are well modified or not, could impair synaptic transmission and plasticity in the rat DG area in vivo and reveal the potential risks of QD applications in biology and medicine, especially in the toxin-susceptible central nervous system (CNS).
Tang
Mingliang
M
Department of Neurobiology and Biophysics, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, PR China.
Li
Zhifeng
Z
Chen
Liang
L
Xing
Tairan
T
Hu
Yong
Y
Yang
Bo
B
Ruan
Di-Yun
DY
Sun
Fei
F
Wang
Ming
M
D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry; D018891:Dentate Gyrus / Q000378:metabolism* / Q000648:ultrastructure; D009473:Neuronal Plasticity; D018384:Oxidative Stress; D045663:Quantum Dots; D051381:Rats; D017208:Rats, Wistar; D018036:Selenium Compounds / Q000737:chemistry; D019809:Streptavidin / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry; D009435:Synaptic Transmission; D017967:Zinc Compounds / Q000737:chemistry
D019187:Cadmium Compounds; D018036:Selenium Compounds; D013440:Sulfides; D017967:Zinc Compounds; D019809:Streptavidin; C058667:cadmium selenide; C031238:zinc sulfide