title: Hostility and minimal model of glucose kinetics in African American women.
abstract: OBJECTIVE
  To explore the underlying physiology of hostility (HOST) and to test the hypothesis that HOST has a greater impact on fasting glucose in African American (AA) women than it does on AA men or white men or women, using an intravenous glucose tolerance test (IVGTT) and the minimal model of glucose kinetics.
  
  
  METHODS
  A total of 115 healthy subjects selected for high or low scores on the 27 item Cook Medley HOST Scale underwent an IVGTT. Fasting nonesterified fatty acids (NEFA) levels were measured before the IVGTT. Catecholamine levels were measured 10 minutes into the IVGTT.
  
  
  RESULTS
  Moderation by group (AA women versus others) of HOST was found for glucose effectiveness (Sg, p = .02), acute insulin response (AIRg, p = .02), and disposition index (DI, p = .02). AA women showed a negative association between HOST and both Sg (beta = -0.45, p = .04) and DI (beta = -0.49, p = .02), controlling for age and body mass index. HOST was also associated with changes in epinephrine (beta = 0.39, p = .05) and fasting NEFA (beta = 0.44, p = .02) in the AA women. Controlling for fasting NEFA reduced the effect of HOST on both Sg and DI.
  
  
  CONCLUSIONS
  This study shows that HOST is related to decreased DI, a measure of pancreatic compensation for increased insulin resistance as well as decreased Sg, a measure of noninsulin-mediated glucose transport compared in AA women. These effects are partly mediated by the relationship of HOST to fasting NEFA.
authors: Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA. Richard.surwit@duke.edu
authors: Richard S
authors: RS
authors: Surwit
authors: James D
authors: JD
authors: Lane
authors: David S
authors: DS
authors: Millington
authors: Haoyue
authors: H
authors: Zhang
authors: Mark N
authors: MN
authors: Feinglos
authors: Sharon
authors: S
authors: Minda
authors: Rhonda
authors: R
authors: Merwin
authors: Cynthia M
authors: CM
authors: Kuhn
authors: Raymond C
authors: RC
authors: Boston
authors: Anastasia
authors: A
authors: Georgiades
mesh_terms: D000328:Adult; D001741:Black or African American / Q000523:psychology / Q000706:statistics & numerical data*; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D004837:Epinephrine / Q000097:blood / Q000378:metabolism; D005215:Fasting / Q000097:blood / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test / Q000706:statistics & numerical data*; D006791:Hostility; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010179:Pancreas / Q000502:physiology; D012307:Risk Factors; D012737:Sex Factors; D044465:White People / Q000523:psychology / Q000706:statistics & numerical data
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D004837:Epinephrine