Metabolic abnormalities in human immunodeficiency virus-infected children: two-year follow-up.
BACKGROUND
HIV-associated lipodystrophy (LD) manifests with fat maldistribution, dyslipidemia, and insulin resistance in some HIV-infected children on antiretroviral therapy.


OBJECTIVE
To assess whether lipid abnormalities in patients with HIV are stable over time.


METHODS
The perinatally HIV-infected cohort at a medium-sized urban US teaching hospital.


METHODS
This prospective, observational study consisted of five visits (at entry and 3, 6, 24, and 30 months after entry) during which fasting venous blood samples were drawn for HIV-1 RNA, CD4 lymphocytes, lipid profile, free fatty acids (FFA), glucose, insulin, and adiponectin. IGF-I/IGFBP-3 levels were measured at the first and fifth visits.


RESULTS
Of 36 study participants, seven were lipodystrophic, and 30 patients completed all five study visits. LDL-cholesterol, total cholesterol (TC), triglycerides (TG), and FFA levels were significantly higher in patients taking protease inhibitors (PIs). Patients with LD had higher TC and TG levels (both p < 0.05), and higher FFA (p = 0.0532). Adiponectin levels did not differ between PI/non-PI and LD/non-LD groups. HDL-cholesterol seemed to decrease, and FFA to increase over time. All IGF-I and all but one IGFBP-3 level were within normal range for age and Tanner stage.


CONCLUSIONS
Dyslipidemia remained relatively constant over our study period. Adiponectin was not useful as a marker of LD in our population.
Krause
Jens C
JC
Division of Pediatric Infectious Diseases, Vanderbilt Children's Hospital, Nashville, TN, USA.
Toye
Mary P
MP
Fisher
Donna J
DJ
Stechenberg
Barbara W
BW
Reiter
Edward O
EO
Allen
Holley F
HF
D052242:Adiponectin / Q000097:blood; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D002648:Child; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000209:etiology; D005230:Fatty Acids, Nonesterified; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications; D039682:HIV-Associated Lipodystrophy Syndrome / Q000209:etiology*; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood
C499918:ADIPOQ protein, human; D052242:Adiponectin; D008078:Cholesterol, LDL; D005230:Fatty Acids, Nonesterified; C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins; D014280:Triglycerides; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol