[Endoplasmic reticulum stress and heart diseases].
Endoplasmic reticulum (ER) is a multifunctional organelle responsible for the synthesis and folding of proteins, calcium storage and synthesis of lipid. Perturbations of ER functional homeostasis result in accumulation of misfolded or unfolded protein in ER, which induces a series of cellular responses (ER stress) through proportional signaling pathway. It is reported that ER stress contributes to development of diseases of heart, including myocardial ischemia-reperfusion injury, cardiomyopathy and heart failure, et al. ER stress might be a novel therapeutic target in heart diseases.
Teng
Xu
X
Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing 100034, China.
Qi
Yong-Fen
YF
Tang
Chao-Shu
CS
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000502:physiology; D059865:Endoplasmic Reticulum Stress; D006331:Heart Diseases / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D017510:Protein Folding; D015427:Reperfusion Injury