A new Borrelia species defined by multilocus sequence analysis of housekeeping genes.
Analysis of Lyme borreliosis (LB) spirochetes, using a novel multilocus sequence analysis scheme, revealed that OspA serotype 4 strains (a rodent-associated ecotype) of Borrelia garinii were sufficiently genetically distinct from bird-associated B. garinii strains to deserve species status. We suggest that OspA serotype 4 strains be raised to species status and named Borrelia bavariensis sp. nov. The rooted phylogenetic trees provide novel insights into the evolutionary history of LB spirochetes.
Margos
Gabriele
G
Department of Biology and Biochemistry, University of Bath, 3 South, Claverton Down, Bath BA2 7AY, United Kingdom. gm250@bath.ac.uk
Vollmer
Stephanie A
SA
Cornet
Muriel
M
Garnier
Martine
M
Fingerle
Volker
V
Wilske
Bettina
B
Bormane
Antra
A
Vitorino
Liliana
L
Collares-Pereira
Margarida
M
Drancourt
Michel
M
Kurtenbach
Klaus
K
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D000954:Antigens, Surface / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics*; D015373:Bacterial Typing Techniques; D001428:Bacterial Vaccines / Q000235:genetics; D001717:Birds / Q000382:microbiology; D001898:Borrelia / Q000145:classification* / Q000235:genetics; D015748:Borrelia burgdorferi Group / Q000145:classification / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D006801:Humans; D018884:Ixodes / Q000382:microbiology; D008074:Lipoproteins / Q000235:genetics; D008193:Lyme Disease / Q000382:microbiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012377:Rodentia / Q000382:microbiology; D017422:Sequence Analysis, DNA; D012703:Serotyping; D013045:Species Specificity
D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D021903:DNA, Ribosomal Spacer; D008074:Lipoproteins; C072045:OspA protein; C079616:OspC protein