[Pro-inflammatory and anti-inflammatory markers in coronary artery disease and acute ischemic coronary syndrome].
Inflammation plays an important role in the development of atherosclerotic lesions, affecting several stages of the atheroma's development going from the initial leukocyte recruitment to the eventual rupture of the unstable atherosclerotic plaque. The inflammatory reactions within coronary atherosclerotic plaques influence the clinical outcome of acute coronary syndromes and coronary artery disease. Recent studies suggest that inflammation markers may reflect different aspects of the atherothrombotic process in relation to the stages of acute coronary syndrome. These markers play an important role in the risk of developing coronary artery disease, and may correlate with its severity. Some cytokines, acute phase proteins, acute phase reactants proteins, and adhesion molecules released from the inflammatory cells may reflect the inflammatory process in atherosclerotic plaques. However, it remains to be determined whether these pro- and anti-inflammation markers may confer risk or protection for cardiovascular disease, or simply reflect the underlying disease process. The analysis of the markers may be useful for the development of new strategies for coronary disease prevention and treatment. Therefore, we need a well-designed evaluation of these markers before their use in the clinical practice.
Fragoso-Lona
José Manuel
JM
Departamento de Biología Molecular, Grupo de Estudio en Genómica y Proteómica de Enfermedades Cardiovasculares, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan, México D.F., México.
Ramírez-Bello
Julián
J
Cruz-Robles
David
D
Pérez-Méndez
Oscar
O
de la Peña
Aurora
A
Vargas-Alarcón
Gilberto
G
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000097:blood; D018925:Chemokines / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000276:immunology; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D017202:Myocardial Ischemia / Q000097:blood / Q000276:immunology; D000685:Serum Amyloid A Protein / Q000032:analysis; D053773:Transforming Growth Factor beta1 / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D018925:Chemokines; D007375:Interleukin-1; D015850:Interleukin-6; D000685:Serum Amyloid A Protein; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D005340:Fibrinogen; D002097:C-Reactive Protein