title: Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase.
abstract: The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.
authors: Department of Pharmacy, Laboratory of Medicinal Chemistry, School of Health Sciences, University of Patras, 26500 Patras, Greece.
authors: Katerina
authors: K
authors: Spyridonidou
authors: Manolis
authors: M
authors: Fousteris
authors: Marazioti
authors: M
authors: Antonia
authors: Athanasia
authors: A
authors: Chatzianastasiou
authors: Andreas
authors: A
authors: Papapetropoulos
authors: Sotiris
authors: S
authors: Nikolaropoulos
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006152:Cyclic GMP / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000071756:Soluble Guanylyl Cyclase
chemical_list: D004791:Enzyme Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D007211:Indoles; D018160:Receptors, Cytoplasmic and Nuclear; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase; D006152:Cyclic GMP