A histone code for regulating V(D)J recombination.
In a recent issue of Molecular Cell, Shimazaki et al. (2009) show that an interaction between RAG2 and a methylated histone might play a critical regulatory role in V(D)J recombination by enhancing DNA binding and enzymatic activity of the V(D)J recombinase.
Schlissel
Mark S
MS
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. mss@berkeley.edu
Schulz
Danae
D
Vettermann
Christian
C
D000818:Animals; D001665:Binding Sites; D053904:DNA Breaks, Single-Stranded; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D006657:Histones / Q000378:metabolism*; D055029:Inverted Repeat Sequences; D008745:Methylation; D051379:Mice; D008957:Models, Genetic; D011995:Recombination, Genetic; D013379:Substrate Specificity; D045567:VDJ Recombinases / Q000378:metabolism
D004268:DNA-Binding Proteins; D006657:Histones; C499308:Rag2 protein, mouse; D045567:VDJ Recombinases