Characteristics and prognosis for molecular breast cancer subtypes in Chinese women.
BACKGROUND
Breast cancer is regarded as a heterogeneous disease with four molecular subtypes. However, the clinicopathological characteristics among the different subtypes have not been studied in Chinese demographic. This study clarifies the prevalence and clinicopathological features of each subtype and investigates the independent prognosis factors in the Chinese population.


METHODS
A retrospective review of 1,820 Chinese breast cancer women were classified into different molecular subtypes based on the IHC-based definitions for ER, PR, and HER-2/neu to evaluate the clinicopathological features and prognosis.


RESULTS
Luminal A subtype was the most prevalent with the oldest median age at first full-term birth. The basal cell-like subtype was associated with early onset, higher percentage of node positivity, family history of breast cancer, increased tumor size, advanced tumor grade, higher prevalence in the premenopausal group, and the earlier age at menarche. Univariate and multivariate analysis of OS and RFS identified the basal cell-like and HER-2/neu subtypes as negative prognostic factors. A family history was an independent predictor of shorter RFS and OS in only the basal cell-like subtype.


CONCLUSIONS
The basal cell-like subtype is associated with a poor prognosis and a family history was a negative predictor in the basal cell-like subtype.
Zhao
Jing
J
Department of Breast Cancer, Cancer Institute & Hospital, Tian Jin Medical University, Tian Jin, PR China.
Liu
Hong
H
Wang
Meng
M
Gu
Lin
L
Guo
Xiaojing
X
Gu
Feng
F
Fu
Li
L
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry / Q000145:classification / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D012189:Retrospective Studies
D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human