Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease.
OBJECTIVE
To investigate the relationship between the severity of Chinese medicine (CM) blood stasis syndrome (BSS) with clinical features and renal lesion indexes of the primary glomerular disease.


METHODS
An epidemiological survey was conducted to collect the data of 227 patients diagnosed as chronic primary glomerular diseases, and their severity of BSS were scored three days before renal biopsies were performed. The following clinical indexes were analyzed: age, course of glomerular diseases, 24-h urine protein ration (Upro), hypertension and blood pressure (BP) progress, serum creatinine levels (Scr), estimation of glomerular filtration rate based on the predigesting equation of MDRD (eGFR), blood urea nitrogen (BUN), uric acid (UA), triglyceride (TG), cholesterol (CHO), haematoglobin (HGB), albumin (ALB), and the correlation among renal pathological types, pathology lesion indexes, and BSS scores.


RESULTS
(1) Among the 227 patients, 207 (91.19%) were diagnosed as BSS, in which 95 cases were considered as moderate and the rest 112 cases as severe. (2) There was a negative correlation between age, gender, grades of the hypertension, and the BSS score. Multiple stepwise regression analysis showed that Upro, CHO, TG, and eGFR were positively related to the BSS score (P<0.05). (3) The BSS score has a positive correlation with indexes of chronic renal pathology, especially the tubular atrophy and interstitial fibrosis. The severity of proliferation and glomerular sclerosis was accompanied with higher BSS scores with a significant difference (P<0.05).


CONCLUSIONS
BSS is one of the most common CM syndromes among patients with the primary glomerular diseases; the BSS score has a positive correlation with Upro, CHO, TG, eGFR, as well as the index of chronic renal pathology. Based on these observations, the BSS may be used as an indicator of the development of renal diseases. Being positively diagnosed as BSS could indicate the beginning of the chronic phase of the primary glomerular diseases.
Li
Shen
S
Department of Nephrology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China. lishen58173@163.com
Rao
Xiang-rong
XR
Wang
Su-xia
SX
Zhang
Gai-hua
GH
Li
Xiao-mei
XM
Dai
Xi-wen
XW
Chen
Ke-ji
KJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001775:Blood Circulation / Q000502:physiology*; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006977:Hypertension, Renal / Q000473:pathology / Q000503:physiopathology; D055048:Integrative Medicine; D007668:Kidney / Q000473:pathology; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D019413:Qi; D051436:Renal Insufficiency, Chronic / Q000473:pathology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D055815:Young Adult