Neural activity in the human brain signals logical rule identification.
To select an appropriate action, we conform to a behavioral rule determined uniquely in each behavioral context. If the rule is not predetermined and must be discovered, we often test hypotheses concerning rules by applying one candidate rule after another. The neural mechanisms underlying such rule identification are still unknown. To explore which brain areas are involved in the process of logical rule identification and to determine whether such areas differ from those taking part in implementing the rule to find a suitable action, we measured brain activation using functional magnetic resonance imaging while subjects performed a rule-identification task. The subjects were required to select a red or blue square on a screen based on either a "sequence rule" or a "probability rule." Positive or negative feedback to the subject's choice led the subject to identify the correct rule. We found that the posterior medial frontal cortex (pMFC), caudate nucleus, fusiform gyrus, and middle temporal cortex exhibited significant activation during the period when subjects underwent the hypothesis testing. Among these brain areas, the pMFC and caudate nucleus were also activated in response to the critical feedback signals selectively during the trials when the subjects identified a rule. Furthermore, we found a significant enhancement in effective connectivity between the active regions in the pMFC and caudate regions.
Tachibana
Kaori
K
Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Suzuki
Kyoko
K
Mori
Etsuro
E
Miura
Naoki
N
Kawashima
Ryuta
R
Horie
Kaoru
K
Sato
Shigeru
S
Tanji
Jun
J
Mushiake
Hajime
H
D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D003210:Concept Formation / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007600:Judgment / Q000502:physiology*; D008128:Logic; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008959:Models, Neurological; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010364:Pattern Recognition, Visual / Q000502:physiology; D012044:Regression Analysis; D017603:Signal Detection, Psychological / Q000502:physiology*; D055815:Young Adult
D010100:Oxygen