The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS.
OBJECTIVE
To assess the concurrent validity and responsiveness of the Health Utility Index 3 (HUI3) in patients with advanced HIV/AIDS, and to determine the responsiveness of this measure, the MOS-HIV and EQ-5D to HIV-related clinical events.


METHODS
Data from the OPTIMA (OPTions In Management with Antiretrovirals) trial was analyzed. Two aspects of the validity of the HUI3 were considered: concurrent validity was evaluated using Spearman correlations with MOS-HIV component and summary scores. Responsiveness to AIDS-defining events (ADE) and all adverse events (our external change criterion) was assessed using area under the receiver operating characteristic (AUROC) curves.


RESULTS
The study enrolled 368 patients (mean follow-up: 3.66 years); 82% had at least one severe adverse event and 27% had at least one ADE. The HUI3 scale and items showed good concurrent validity, with 85% of the expected relationships with the MOS-HIV subscales verified. The HUI3 was responsive to both adverse events (AUROC [95%CI]: 0.68 [0.57, 0.80]) and ADEs (0.62 [0.51, 0.74]). The EQ-5D was responsive to ADEs (0.66 [0.56, 0.76]), but not responsive to adverse events (0.56 [0.46, 0.68]).


CONCLUSIONS
The HUI3 is a valid and responsive measure of the change in HRQoL associated with clinical events in an advanced HIV/AIDS population.
Nosyk
Bohdan
B
Canadian HIV Trials Network, St. Paul's Hospital, 620-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada. bnosyk@mail.cheos.ubc.ca
Sun
Huiying
H
Bansback
Nick
N
Guh
Daphne P
DP
Li
Xin
X
Barnett
Paul
P
Bayoumi
Ahmed
A
Griffin
Susan
S
Joyce
Vilija
V
Holodniy
Mark
M
Owens
Doug K
DK
Anis
Aslam H
AH
D000163:Acquired Immunodeficiency Syndrome / Q000523:psychology*; D005260:Female; D015658:HIV Infections / Q000523:psychology*; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D019057:Quality-Adjusted Life Years; D015203:Reproducibility of Results; D012720:Severity of Illness Index