title: MIRO and IRbase: IT tools for the epidemiological monitoring of insecticide resistance in mosquito disease vectors.
abstract: BACKGROUND
  Monitoring of insect vector populations with respect to their susceptibility to one or more insecticides is a crucial element of the strategies used for the control of arthropod-borne diseases. This management task can nowadays be achieved more efficiently when assisted by IT (Information Technology) tools, ranging from modern integrated databases to GIS (Geographic Information System). Here we describe an application ontology that we developed de novo, and a specially designed database that, based on this ontology, can be used for the purpose of controlling mosquitoes and, thus, the diseases that they transmit.
  
  
  RESULTS
  The ontology, named MIRO for Mosquito Insecticide Resistance Ontology, developed using the OBO-Edit software, describes all pertinent aspects of insecticide resistance, including specific methodology and mode of action. MIRO, then, forms the basis for the design and development of a dedicated database, IRbase, constructed using open source software, which can be used to retrieve data on mosquito populations in a temporally and spatially separate way, as well as to map the output using a Google Earth interface. The dependency of the database on the MIRO allows for a rational and efficient hierarchical search possibility.
  
  
  CONCLUSIONS
  The fact that the MIRO complies with the rules set forward by the OBO (Open Biomedical Ontologies) Foundry introduces cross-referencing with other biomedical ontologies and, thus, both MIRO and IRbase are suitable as parts of future comprehensive surveillance tools and decision support systems that will be used for the control of vector-borne diseases. MIRO is downloadable from and IRbase is accessible at VectorBase, the NIAID-sponsored open access database for arthropod vectors of disease.
authors: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.
authors: Emmanuel
authors: E
authors: Dialynas
authors: Pantelis
authors: P
authors: Topalis
authors: John
authors: J
authors: Vontas
authors: Christos
authors: C
authors: Louis
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D009033:Culicidae / Q000187:drug effects*; D016208:Databases, Factual; D004199:Disease Vectors; D004784:Environmental Monitoring / Q000379:methods*; D062665:Epidemiological Monitoring; D006801:Humans; D007305:Insecticide Resistance; D009032:Mosquito Control / Q000379:methods*