Short sleep duration is associated with a blood pressure nondipping pattern in type 1 diabetes: the DIAPASOM study.
OBJECTIVE
To assess whether nocturnal blood pressure dipping status in type 1 diabetes is correlated with specific sleep characteristics and differences in nocturnal glycemic profiles.


METHODS
Twenty type 1 diabetic adult patients underwent sleep studies with simultaneous 24-h ambulatory blood pressure monitoring and continuous nocturnal glucose monitoring.


RESULTS
Altogether, 55% of patients exhibited blunted blood pressure dipping. They did not differ from the dipper group in age, BMI, or systolic (SBP) and diastolic (DBP) blood pressure. Total sleep period (TSP) was higher in the dipper group (497 +/- 30 vs. 407 +/- 44 min for dippers and nondippers, respectively, P < 0.001). TSP was correlated with SBP and DBP day-night differences (r = 0.44 and 0.49, respectively). Periods of nocturnal hypoglycemia (i.e., % of TSP with glycemia <70 mg/dl) were longer in the dipper group (8.1 +/- 10.7 vs. 0.1 +/- 0.4% for dippers and nondippers, respectively, P = 0.02).


CONCLUSIONS
Dipping status in type 1 diabetes was associated with longer sleep duration and with hypoglycemia unawareness.
Borel
Anne-Laure
AL
Endocrinology Department, University Hospital, Pôle Digidune, Joseph Fourier University, Grenoble, France. alborel@chu-grenoble.fr
Benhamou
Pierre-Yves
PY
Baguet
Jean-Philippe
JP
Debaty
Isabelle
I
Levy
Patrick
P
Pépin
Jean-Louis
JL
Mallion
Jean-Michel
JM
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012890:Sleep / Q000502:physiology*