Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.
Matrix metalloproteinases (MMPs) have been implicated in a variety of normal and pathological conditions that involve matrix degradation and remodelling. We investigated the role of MMPs in acute graft-versus-host disease (aGVHD) in 29 patients who had undergone allogeneic haematopoietic stem cell transplantation. The present study showed that the serum levels of MMP-9, but not those of MMP-2, significantly correlated with the occurrence and severity of aGVHD. Moreover, immunohistochemical analysis of the cutaneous lesions of patients with aGVHD revealed an increased number of inflammatory cells positive for MMP-9. These results suggest that MMP-9 might play an important role in the pathogenesis of aGVHD.
Tagami
Kozo
K
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Yujiri
Toshiaki
T
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan. yujirit@yamaguchi-u.ac.jp.|Third Department of Internal Medicine, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan. yujirit@yamaguchi-u.ac.jp.
Takahashi
Toru
T
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Kizuki
Nobuaki
N
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Tanaka
Yoshinori
Y
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Mitani
Noriyuki
N
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Nakamura
Yukinori
Y
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Ariyoshi
Koichi
K
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Ando
Toshihiko
T
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Gondo
Toshikazu
T
First Department of Pathology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Tanizawa
Yukio
Y
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood* / Q000209:etiology* / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D014184:Transplantation, Homologous; D055815:Young Adult
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9