Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification.
The synthesis and SAR of a new series of potent and selective dopamine D(3) receptor antagonists is reported.
Holmes
Ian P
IP
Cancer Therapeutics, Melbourne, Australia.
Micheli
Fabrizio
F
Gaines
Simon
S
Lorthioir
Olivier
O
Watson
Steve P
SP
Fabio
Romano Di
RD
Gentile
Gabriella
G
Heidbreder
Christian
C
Savoia
Chiara
C
Worby
Angela
A
D000818:Animals; D002415:Cats; D051638:Ether-A-Go-Go Potassium Channels / Q000378:metabolism; D006801:Humans; D048289:Imidazolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008024:Ligands; D049268:Positron-Emission Tomography; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
D051638:Ether-A-Go-Go Potassium Channels; D048289:Imidazolidines; C496884:KCNH1 protein, human; D008024:Ligands; D050637:Receptors, Dopamine D3