title: Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica.
abstract: Eight new prenylated flavonoids, ugonins M-T (1-8), together with five known compounds, ugonins J-L (9-11), 5,4'-dihydroxy-4'',4''-dimethyl-5''-methyl-5''H-dihydrofurano[2'',3'':6,7]flavanone, and quercetin, were isolated and purified from the rhizomes of Helminthostachys zeylanica. The structures of the new isolates were elucidated by spectroscopic and chemical methods. Compounds 1, 3, 5, 7, 8, and 11 showed inhibition of superoxide anion generation and elastase release by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (FMLP/CB).
authors: Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung 404, Taiwan, Republic of China.
authors: Yaun-Chao
authors: YC
authors: Huang
authors: Tsong-Long
authors: TL
authors: Hwang
authors: Chih-Shiang
authors: CS
authors: Chang
authors: Yu-Liang
authors: YL
authors: Yang
authors: Chia-Ning
authors: CN
authors: Shen
authors: Wen-Ying
authors: WY
authors: Liao
authors: Sheng-Chih
authors: SC
authors: Chen
authors: Chih-Chuang
authors: CC
authors: Liaw
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003571:Cytochalasin B / Q000494:pharmacology; D029624:Ferns / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects*; D027343:Rhizome / Q000737:chemistry; D013624:Taiwan
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D003571:Cytochalasin B; D009240:N-Formylmethionine Leucyl-Phenylalanine