Sclerosing nevus with pseudomelanomatous features (nevus with regression-like fibrosis): clinical and dermoscopic features of a recently characterized histopathologic entity.
BACKGROUND
Sclerosing nevi with pseudomelanomatous features or, else, nevi with regression-like fibrosis (NRLF) are histopathologic simulators of regressing melanoma.


OBJECTIVE
We aimed at evaluating the clinical features in a series of NRLF.


METHODS
Dermoscopic images of NRLF were re-evaluated according to the amount of regression, the presence of white/blue areas and the 7-point checklist.


RESULTS
Forty-six lesions from 44 patients (M:F = 3.4:1; mean age: 42 years) were evaluated. Thirty-seven lesions were excised from the back, mostly from the scapular area. All the lesions were dermoscopically atypical, with large amounts of regression (>10% in 43 cases) and with coexistence of white and blue areas (41 cases). According to the 7-point checklist, 25 lesions were labeled as benign, probably because regression obscured other dermoscopic features of atypia.


CONCLUSIONS
NRLF are mostly found in the convex area of the back. A better recognition of their clinicopathologic features can allow a more conservative management.
Ferrara
Gerardo
G
Department of Oncology, Pathologic Anatomy Unit, Gaetano Rummo General Hospital, Benevento, Italy.
Giorgio
Caterina M
CM
Zalaudek
Iris
I
Broganelli
Paolo
P
Pellacani
Giovanni
G
Tomasini
Carlo
C
Argenziano
Giuseppe
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D046169:Dermoscopy / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000175:diagnosis; D008875:Middle Aged; D009506:Nevus / Q000473:pathology*; D012598:Sclerosis / Q000473:pathology; D055815:Young Adult