Subfornical organ: Duration of dipsogenic action of angiotensin-II.
Prior evidence from our laboratory has implicated the subfornical organ (SFO) as a site of angiotensin-II (A-II)-induced drinking [22]. In the present study, animals were denied access to water for 0, 0.5 and 1.0 h following a single intracranial A-II injection into the SFO. Even after a delay of 1.0 h, A-II-injected animals showed increased water consumption compared to controls. Animals injected with A-II and tested immediately consumed significantly more water than the 1 h delay animals. Potential mechanisms involved in the maintenance of the drinking effect of A-II after 1 h and the decreased drinking in 1.0 h relative to the 0 h group were considered.
Mitrius
J
J
Cresap Neuroscience Laboratory, Northwestern University, Evanston, Ill. 60201 U.S.A.
Routtenberg
A
A