title: Pulsed-wave tissue Doppler and color tissue Doppler echocardiography: calibration with M-mode, agreement, and reproducibility in a clinical setting.
abstract: BACKGROUND
  Myocardial velocities can be measured with both pulsed-wave tissue Doppler (PWTD) and color tissue Doppler (CTD) echocardiography. We aimed to (A) to explore which of the two methods better approximates true tissue motion and (B) to examine the agreement and the reproducibility of the two methods in a routine clinical setting.
  
  
  METHODS
  For Study A, the displacements of 63 basal myocardial segments from 13 patients were examined with M-mode and compared with the velocity-time integral of PWTD and CTD velocities. For Study B, the basal lateral segments from 58 patients were examined with PWTD and CTD, and the peak myocardial velocities during systole (Sm), early diastole (Em), and late diastole (Am) were measured.
  
  
  RESULTS
  Study A: CTD-based measurements of displacement were 12% lower than M-mode measurements (95% CI: -18%; -6%). PWTD velocity-time integrals measured at the outer edge of the spectral band were 40% higher (33%; 46%) than M-mode measurements. Study B: PWTD measurements of myocardial velocity were systematically higher than CTD measurements: Sm 7.51 versus 5.54, difference 1.97 +/- 1.41 cm/sec; Em 8.74 versus 6.86, difference 1.88 +/- 1.70 cm/sec; Am 7.46 versus 5.17, difference 2.29 +/- 1.82 cm/sec; P < 0.001 for all. Intraobserver coefficient of variation for Sm, Em, and Am were 6%, 12%, and 12% for PWTD, 14%, 13%, and 20% for CTD.
  
  
  CONCLUSIONS
  CTD measures numerically smaller tissue velocities than PWTD, mostly due to an overestimation of true tissue motion by PWTD. The methods have good agreement and comparable reproducibility.
authors: Department of Cardiology, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. thueolsen@post.tele.dk
authors: Niels Thue
authors: NT
authors: Olsen
authors: Christian
authors: C
authors: Jons
authors: Thomas
authors: T
authors: Fritz-Hansen
authors: Rasmus
authors: R
authors: Mogelvang
authors: Peter
authors: P
authors: Sogaard
mesh_terms: D000368:Aged; D002138:Calibration; D003718:Denmark; D018618:Echocardiography, Doppler, Color / Q000379:methods* / Q000592:standards; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods* / Q000592:standards; D054459:Elasticity Imaging Techniques / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging*