Design and evaluation of succinylated soy protein tablets as delayed drug delivery systems.
The impact of succinylation on soy proteins as excipients for delayed delivery of drugs in the gastrointestinal tract was studied. Succinylation decreased protein solubility and protein charge density at pH 1.2 and increased solubility and zeta potential at pH above 4.5. Tablet erosion and swelling were decreased at pH 1.2 and increased at pH 7.5. FTIR analysis indicated polypeptide chain unfolding as a result of succinylation. Tablets of protein succinylated 50% or 100% released less than 10% of loaded riboflavin or rifampicin in 2h at gastric pH in the presence of pepsin but released these compounds rapidly at intestinal pH. Succinylated soy protein tablets were thus gastroresistant, suggesting their use as excipients for controlled release of medicinal or nutraceutical agents.
Caillard
R
R
Chaire de Recherche du Canada sur les Protéines, les Biosystèmes et les Aliments Fonctionnels, Institut des Nutraceutiques et Aliments Fonctionnels (INAF), Faculté des Sciences de l'Agriculture et de l'Alimentation, Université Laval, Pavillon Paul Comtois, Québec G1K7P4, Canada.
Petit
A
A
Subirade
M
M
D055598:Chemical Phenomena; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D007421:Intestine, Small / Q000378:metabolism; D007700:Kinetics; D012256:Riboflavin / Q000737:chemistry / Q000378:metabolism; D012293:Rifampin / Q000737:chemistry / Q000378:metabolism; D012995:Solubility; D030262:Soybean Proteins / Q000737:chemistry*; D019802:Succinic Acid / Q000737:chemistry*; D013607:Tablets; D014867:Water / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D030262:Soybean Proteins; D013607:Tablets; D014867:Water; D019802:Succinic Acid; D012256:Riboflavin; D012293:Rifampin