title: Syndrome of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) in siblings.
abstract: PFAPA syndrome is characterized by episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. PFAPA syndrome usually begins in children under 5 years old and normally has self-resolution. The etiology of PFAPA syndrome remains unknown. In this paper, we report the cases of two different families with siblings with PFAPA syndrome: two sisters and two brothers. To our knowledge, this is the first report of siblings with PFAPA syndrome.
authors: Department of Pediatrics, Pontificia Universidad Católica de Chile, Lira 85, 5th floor, Santiago, Chile. pvalenzu@med.puc.cl
authors: Patricia M
authors: PM
authors: Valenzuela
authors: Daniela
authors: D
authors: Majerson
authors: Jose L
authors: JL
authors: Tapia
authors: Eduardo
authors: E
authors: Talesnik
mesh_terms: D002648:Child; D002675:Child, Preschool; D002677:Chile; D010505:Familial Mediterranean Fever / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008199:Lymphadenitis / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D010612:Pharyngitis / Q000175:diagnosis* / Q000209:etiology; D035781:Siblings; D013281:Stomatitis, Aphthous / Q000175:diagnosis* / Q000209:etiology; D013577:Syndrome