title: Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia.
abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs are believed to be related to mutational activation of receptor tyrosine kinases, KIT, or platelet-derived growth factor receptor-alpha. The coexistence of GISTs with other neoplasms has been extensively addressed in the literature. The most common second neoplasms are colorectal cancer, prostate cancer, and neoplasms derived from lymphoid tissue. In this case report, we describe a patient affected by GIST and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. The clinicopathological characteristics of the patient are discussed and the literature is reviewed.
authors: Department of Hematology, Karadeniz Technical University School of Medicine, Trabzon, Turkey. mesonmez@yahoo.com
authors: Mehmet
authors: M
authors: Sonmez
authors: Mehmet
authors: M
authors: Arslan
authors: Umit
authors: U
authors: Cobanoglu
authors: Halil
authors: H
authors: Kavgaci
authors: Hasan Mucahit
authors: HM
authors: Ozbas
authors: Fazil
authors: F
authors: Aydin
authors: Ercument
authors: E
authors: Ovali
authors: Serdar Bedii
authors: SB
authors: Omay
mesh_terms: D000368:Aged; D000753:Anemia, Refractory / Q000209:etiology* / Q000473:pathology; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000150:complications* / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000473:pathology