Different times of development of tremor to harmaline and oxotremorine in neonatal rats.
Neonatal rats at 1-2 days after birth were injected with the tremorogenic drugs harmaline and oxotremorine. The onset of tremor to the drugs was significantly different (P < 0.01). Tremor induced by oxotremorine first appeared at day 4 and by day 10 was observed in every rat. Harmaline induced tremor appeared later, developing between days 9-12. All rats showed tremor in response to harmaline at day 12 and afterwards. The difference in time of onset between the response to the two drugs reflects different brain sites of action. The development of harmaline induced tremor may reflect the functional synaptic maturation of the olivo-cerebellar circuit.
Phillips
M I
MI
Department of Physiology & Biophysics, University of Iowa, Iowa City, Iowa 52242, USA.
Knowles
W D
WD
January
C T
CT