IL-33 raises alarm.
The interleukin-1 (IL-1)-like cytokine IL-33 is widely assumed to undergo proteolytic maturation by caspase-1. In this issue of Immunity, Lüthi et al. (2009) show that IL-33 is not a caspase-1 substrate. IL-33 is inactivated by caspase-3 and -7 to prevent an inappropriate immune response during apoptosis, but not in necrosis.
Lamkanfi
Mohamed
M
Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Dixit
Vishva M
VM
D000818:Animals; D020170:Caspase 1 / Q000276:immunology / Q000378:metabolism; D053148:Caspase 3 / Q000276:immunology / Q000378:metabolism; D053179:Caspase 7 / Q000276:immunology / Q000378:metabolism; D016923:Cell Death / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D042783:Endothelial Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D000067596:Interleukin-33; D007378:Interleukins / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; C506536:IL33 protein, human; C506535:Il33 protein, mouse; D000067596:Interleukin-33; D007378:Interleukins; D053148:Caspase 3; D053179:Caspase 7; D020170:Caspase 1