title: The anti-fibrotic agent SMP-534 attenuates bleomycin-induced pulmonary fibrosis in hamsters.
abstract: Pulmonary fibrosis is a progressive and lethal lung disease characterized by accumulation of ECM and loss of pulmonary function. However, no cure exists for this disease, and current treatments often fail to slow its progression or relieve its symptoms. We have previously reported that the anti-fibrotic agent SMP-534 has beneficial effects on renal fibrosis in animal model of nephropathy. In this study, we examined whether SMP-534 has beneficial effects on pulmonary fibrosis in bleomycin-treated hamsters. Treatment with SMP-534 [low dose (70 mg/kg) or high dose (110 mg/kg)] counteracted inhibition of body weight increase induced by bleomycin. In addition, SMP-534 significantly inhibited bleomycin-induced increase in lung hydroxyproline level, an index of collagen formation. Moreover, SMP-534 significantly ameliorated histological pulmonary fibrotic changes induced by bleomycin. The results of this study indicate that the anti-fibrotic agent SMP-534 may offer a new therapeutic option for the treatment of pulmonary fibrosis.
authors: Pharmacology Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd, Konohana-ku, Osaka, Japan.
authors: Tsuyoshi
authors: T
authors: Tsujimura
authors: Michiko
authors: M
authors: Ono-Kishino
authors: Jun
authors: J
authors: Nagamine
authors: Eiji
authors: E
authors: Sugaru
authors: Teruhisa
authors: T
authors: Tokunaga
authors: Makoto
authors: M
authors: Kitoh
authors: Ryu
authors: R
authors: Nagata
authors: Tsutomu
authors: T
authors: Nakagawa
authors: Mutsuo
authors: M
authors: Taiji
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001549:Benzamides / Q000627:therapeutic use*; D001761:Bleomycin / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D011897:Random Allocation
chemical_list: D000903:Antibiotics, Antineoplastic; D001549:Benzamides; C505358:SMP-534; D001761:Bleomycin; D006909:Hydroxyproline