title: Re-evaluation of the role of STOX1 transcription factor in placental development and preeclampsia.
abstract: Preeclampsia is a common disease of pregnancy, characterized by high blood pressure and proteinuria appearing from the second trimester of gestation. Preeclampsia has been shown to have a strong genetic component. In 2005 a positional cloning project led to the discovery of the STOX1 transcription factor, and mutations of this gene were proposed as causal for preeclampsia in Dutch families. Despite the publication of three contradictory studies, we have shown by analyzing the functional effects of STOX1 that its overexpression in choriocarcinoma cells recapitulates several transcriptomic aspects of preeclampsia. In this review, the current literature is analyzed to evaluate the possible involvement of STOX1 in the pathogenesis of this disease. While preeclampsia obviously cannot be considered as a disease caused by mutation in a single gene, we argue that STOX1 may be at the center of common pathways leading to preeclampsia.
authors: Equipe 21, Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France.
authors: Virginie
authors: V
authors: Rigourd
authors: Sonia
authors: S
authors: Chelbi
authors: Caroline
authors: C
authors: Chauvet
authors: Régis
authors: R
authors: Rebourcet
authors: Sandrine
authors: S
authors: Barbaux
authors: Bettina
authors: B
authors: Bessières
authors: Françoise
authors: F
authors: Mondon
authors: Thérèse-Marie
authors: TM
authors: Mignot
authors: Jean-Louis
authors: JL
authors: Danan
authors: Daniel
authors: D
authors: Vaiman
mesh_terms: D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D010929:Placentation / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D021381:Protein Transport; D014158:Transcription, Genetic
chemical_list: D002352:Carrier Proteins; C500784:STOX1 protein, human