High sensitive determination of zinc with novel water-soluble small molecular fluorescent sensor.
A high sensitive method of quantitative analysis for the determination of zinc in the nutrition supplements has been developed by using a novel water-soluble fluorescent sensor HQ3: (8-pyridylmethyloxy-2-methyl-quinoline). Under the optimized condition of 67 mM phosphate buffer, pH 7.4, and 5% (v/v) DMSO, the zinc concentration showed good linear relationship with fluorescence intensity in the range of 7.5 x 10(-8) to 2.5 x 10(-5) M with the detection limit of 1.5 x 10(-8) M. HQ3 exhibited high selectivity to zinc comparing with other metal ions except for cadmium. The developed analytical method was successfully used for determining the content of zinc in a real sample of zinc gluconate solution of Sanchine.
Weng
Ying
Y
Department of Pharmaceutical Analysis, College of Pharmacy, Wuhan University, Wuhan, Hubei 430072, China.
Chen
Zilin
Z
Wang
Fang
F
Xue
Lin
L
Jiang
Hua
H
D019587:Dietary Supplements / Q000032:analysis*; D004492:Edetic Acid / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D005942:Gluconates / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D016014:Linear Models; D011804:Quinolines / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014867:Water; D015032:Zinc / Q000032:analysis*
D005456:Fluorescent Dyes; D005942:Gluconates; D011804:Quinolines; D014867:Water; D004492:Edetic Acid; C037219:quinoline; D015032:Zinc; C030691:gluconic acid