title: Experimental study of the tissue reaction caused by the presence of cellulose produced by Acetobacter xylinum in the nasal dorsum of rabbits.
abstract: Several materials have been proposed for nasal reconstruction. There is no consensus on which is the best. The cellulose blanket produced by bacteria may be a possible cartilaginous addition element to the nose.
  
  
  OBJECTIVE
  to study tissue reaction to cellulose in the dorsal nose of rabbits.
  
  
  METHODS
  22 New Zealand rabbits were used. In 20 a cellulose blanket was implanted in the nasal dorsum and 2 served as controls. They were followed up through a period of three and six months, after which their nostrils and nasal dorsums were removed and histological studies were carried out on them, considering defined parameters of inflammation such as vascular congestion, intensity of the inflammatory process and presence of purulent exudate.
  
  
  RESULTS
  The inflammatory process remained stable, showing its relationship with the surgical procedure and not with the presence of the cellulose blanket. There were no statistical differences in the other parameters.
  
  
  CONCLUSIONS
  The cellulose blanket produced by Acetobacter xylinum presented good biocompatibility, remained stable during the entire study period, and could be considered a good material for elevating the nasal dorsum.
authors: Santa casa de São Paulo.
authors: Wander Lopes
authors: WL
authors: Amorim
authors: Henrique Olival
authors: HO
authors: Costa
authors: Flávia Coelho de
authors: FC
authors: Souza
authors: Marilia Germanos de
authors: MG
authors: Castro
authors: Leonardo da
authors: Ld
authors: Silva
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002356:Cartilage / Q000637:transplantation*; D002482:Cellulose / Q000096:biosynthesis*; D004195:Disease Models, Animal; D041822:Gluconacetobacter xylinus / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008422:Materials Testing; D009666:Nose / Q000382:microbiology*; D009668:Nose Diseases / Q000601:surgery*; D011817:Rabbits; D019651:Plastic Surgery Procedures / Q000379:methods; D018709:Statistics, Nonparametric
chemical_list: D001672:Biocompatible Materials; D002482:Cellulose