title: Successful management of presumed Candida endogenous endophthalmitis with oral voriconazole.
abstract: Endogenous fungal endophthalmitis is most commonly caused by Candida species and usually occurs in patients with chronic diseases such as diabetes mellitus and renal insufficiency. Voriconazole, a broad-spectrum triazole antifungal agent, attains therapeutically significant concentrations in the vitreous cavity after systemic administration. We report, the successful management of presumed endogenous Candida endophthalmitis in a patient with multiple diseases and unstable systemic status with oral voriconazole. Though fungal endophthalmitis has been successfully treated with a combination of intravenous and intravitreal voriconazole, to the best of our knowledge this is the first report in ophthalmic literature (Medline Search) on the treatment of fungal endophthalmitis with only the oral route of administration of voriconazole.
authors: Ranjini Eye Care, Cochin, Kerala, India. drbijuraju@gmail.com
authors: Raju
authors: R
authors: Biju
authors: Daniel
authors: D
authors: Sushil
authors: Nainan K
authors: NK
authors: Georgy
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D002177:Candidiasis / Q000188:drug therapy*; D009877:Endophthalmitis / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D005122:Exudates and Transudates / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000008:administration & dosage*; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D014822:Vitreous Body / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole