title: Prestroke physical activity and early functional status after stroke.
abstract: BACKGROUND
  The importance of physical activity as a modifiable risk factor for stroke in particular and cardiovascular disease in general is well documented. The effect of exercise on stroke severity and stroke outcomes is less clear. This study aimed to assess that effect.
  
  
  METHODS
  Data collected for patients enrolled in the Ischemic Stroke Genetics Study were reviewed for prestroke self-reported levels of activity and four measures of stroke outcome assessed at enrollment and approximately 3 months after enrollment. Logistic regression was used to assess the association between physical activity and stroke outcomes, unadjusted and adjusted for patient characteristics.
  
  
  RESULTS
  A total of 673 patients were enrolled; 50.5% reported aerobic physical activity less than once a week, 28.5% reported aerobic physical activity one to three times weekly, and 21% reported aerobic physical activity four times a week or more. Patients with moderate and high levels of physical activity were more likely to have higher Barthel Index (BI) scores at enrollment. A similar association was detected for exercise and good outcomes for the Oxford Handicap Scale (OHS). After 3 months of follow-up, moderate activity was still associated with a high BI score. No significant association was detected for activity and the OHS or Glasgow Outcome Scale at follow-up after adjustment for patient characteristics.
  
  
  CONCLUSIONS
  Higher levels of self-reported prestroke physical activity may be associated with functional advantages after stroke. Our findings should be seen as exploratory, requiring confirmation, ideally in a longitudinal study of exercise in an older population.
authors: Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
authors: N
authors: N
authors: Stroud
authors: T M L
authors: TM
authors: Mazwi
authors: L D
authors: LD
authors: Case
authors: R D
authors: RD
authors: Brown
authors: T G
authors: TG
authors: Brott
authors: B B
authors: BB
authors: Worrall
authors: J F
authors: JF
authors: Meschia
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000150:complications; D002544:Cerebral Infarction / Q000453:epidemiology / Q000473:pathology; D015331:Cohort Studies; D004185:Disability Evaluation; D015444:Exercise / Q000502:physiology; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D007899:Leisure Activities; D016015:Logistic Models; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D020521:Stroke / Q000209:etiology / Q000503:physiopathology*; D016896:Treatment Outcome