[Repair effect of BMSCs on digestive tract injury].
OBJECTIVE
To investigate the effect of BMSCs on the repair of digestive tract injury and its mechanisms.


METHODS
Recent literature on the effect of BMSCs on the repair of digestive tract injury was reviewed.


RESULTS
BMSCs had the potency of self-replication, proliferation and multipotential differentiation, which played an important role in the repair of digestive tract injury. The probable mechanisms included: BMSCs' ability of migrating to the injured tissue and inhibiting the host immune response; BMSCs' dedifferentiation and redifferentiation; BMSCs' direct differentiation into the epithelial cells or the stem cells of digestive tract; BMSCs' fusion with the stem cells or the mature epithelial cells of digestive tract; BMSCs' participation in the reconstruction of injured microenvironment.


CONCLUSIONS
BMSCs participates in the repair of digestive tract injury and has a bright future in the treatment of digestive system disease.
Jia
Guiqing
G
Department of Gastrointestional Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, PR China.
Zhang
Mingming
M
Wu
Xiaoting
X
D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology*; D002454:Cell Differentiation; D041981:Gastrointestinal Tract / Q000473:pathology*; D013234:Stem Cells / Q000166:cytology / Q000473:pathology*; D014945:Wound Healing