Dioxygen activation by mononuclear copper enzymes: insights from a tripodal ligand mimicking their Cu(M) coordination sphere.
A mononuclear cuprous complex is proposed as a novel in silico model for the Cu(M) active site of noncoupled copper monooxygenases. To the best of our knowledge, it is one of the first biomimicking models that allows one to recover the intimate structural features of the enzymatic oxygenated adducts and to gain clear-cut insights relevant to dioxygen activation by these enzymes.
de la Lande
Aurélien
A
UPMC Université Paris 6 and CNRS, UMR 7616, Laboratoire de Chimie Théorique, 4 place Jussieu, 75252 Paris Cedex 05, France. delaland@ucalgary.ca
Salahub
Dennis
D
Moliner
Vicent
V
Gérard
Hélène
H
Piquemal
Jean-Philip
JP
Parisel
Olivier
O
D040761:Biomimetic Materials / Q000737:chemistry*; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D010105:Oxygenases / Q000737:chemistry* / Q000378:metabolism; D017434:Protein Structure, Tertiary
D008024:Ligands; D003300:Copper; D010105:Oxygenases; D010100:Oxygen