p53-Induced apoptosis and inhibitors of p53.
Protein p53 is a key player in mitochondrial mediated apoptotic cell death and excess p53 activity has been implicated in many disease states such athrosclerosis, diabetes, osteoarthritis, Alzheimer's disease, Parkinson's disease, Huntington's disease, AIDS, P. falciparum and S. typhimurium infections. Thus, chemical inhibitors of p53 activation might prove effective in suppressing diseases associated with excess p53 activity. Diverse chemical compounds are being synthesized and evaluated as potent inhibitors of p53 in many cell types. In this review, we have focused on the effects of apoptosis, which is involved in p53 protein and inhibition of p53 induced apoptosis. Peculiar features of p53 protein and its roles in various diseases are summarized along with important inhibitors developed in recent years.
Nayak
Surendra Kumar
SK
Department of Chemistry, Sant Longowal Institute Engineering & Technology (Deemed University), Sangrur, India.
Panesar
Paramjit Singh
PS
Kumar
Harish
H
D004999:Amifostine / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000209:etiology; D052160:Benzothiazoles / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000209:etiology; D019636:Neurodegenerative Diseases / Q000209:etiology; D015739:Nocodazole / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction; D012871:Skin Diseases / Q000209:etiology; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors* / Q000378:metabolism*
D052160:Benzothiazoles; D016159:Tumor Suppressor Protein p53; D004999:Amifostine; D015739:Nocodazole