[Clinicopathologic features and diagnosis of 18 patients with angioimmunoblastic T-cell lymphoma].
OBJECTIVE
To explore the clinical and pathologic features of angioimmunoblastic T-cell lymphoma(AITL) and provide evidence for diagnosis.


METHODS
Eighteen AITL patients (9 males and 9 females aged from 14 to 70 years) were retrospectively analyzed in Xiangya Hospital of Central South University from July 2002 to September 2007.


RESULTS
Characteristic features at the presentation of AITL included generalized lymphadenopathy, fever, splenomegaly, and skin rashes with polyclonal hyper-gammaglobulinemia and other hematological abnormalities (such as Coombs-positive hemolytic anemia), which often involved the bone marrow and had well-described histologic features. The positive rate for CXCL13 was 93.3%.


CONCLUSIONS
Repeated lymphadenbiopsy is helpful for AITL diagnosis. Routine histological and immunohistochemical examinations (especially including CXCL13) play significant role in the diagnosis and differential diagnosis of AITL.
Yuan
Xiaoyu
X
Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China.
Chen
Fangping
F
Bi
Dandong
D
Zhao
Xielan
X
He
Qiongqiong
Q
Li
Qun
Q
D000293:Adolescent; D000328:Adult; D000368:Aged; D054382:Chemokine CXCL13 / Q000378:metabolism; D005260:Female; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
C110663:CXCL13 protein, human; D054382:Chemokine CXCL13