Memory-prediction errors and their consequences in schizophrenia.
Cognitive deficits play a central role in the onset of schizophrenia. Cognitive impairment precedes the onset of psychosis in at least a subgroup of patients, and accounts for considerable dysfunction. Yet cognitive deficits as currently measured are not significantly related to hallucinations and delusions. Part of this counterintuitive absence of a relationship may be caused by the lack of an organizing principle of cognitive impairment in schizophrenia research. We review literature suggesting that a system of memory-based prediction is central to human perception, thought and action , and forward the notion that many of the symptoms of schizophrenia are a result of a failure of this system.
Kraus
Michael S
MS
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. michael.kraus@duke.edu
Keefe
Richard S E
RS
Krishnan
Ranga K R
RK
D000818:Animals; D001921:Brain / Q000503:physiopathology; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000503:physiopathology; D006801:Humans; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000503:physiopathology; D008962:Models, Theoretical; D010465:Perception / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology; D012565:Schizophrenic Psychology