[Body mass regulation by estrogen and physical activity].
Female steroid hormones deficiency leads to a significant increase in body mass, but the possible central and peripheral mechanisms involved in increased food ingestion and fat accumulation in this situation are still unknown. In animal models, the specific lack of estrogen or its action produce progressive body mass gain, clearly demonstrating the possible role of this hormone in overweight after menopause. Obesity and overweight correspond to a relevant human health problem that can lead to premature death. Therefore unraveling the mechanisms underlying body mass gain is of great relevance, as well as the development of strategies to prevent its establishment. Energy balance regulation is associated with the control of body mass, and physical exercise is an important modulator of this homeostatic parameter. However, the influence of physical exercise in mass gain development during estrogen deficiency is controversial and depends on the exercise protocol used. In this study, we intend to review the data on the effects of estrogen deficiency on body mass gain in humans and animal models.
Ignacio
Daniele L
DL
Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho (IBCCF), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.
Frankenfeld
Tamar G P
TG
Fortunato
Rodrigo S
RS
Vaisman
Mário
M
Werneck-de-Castro
João Pedro Saar
JP
Carvalho
Denise P
DP
D000818:Animals; D001141:Aromatase / Q000378:metabolism; D050218:Body Fat Distribution; D015992:Body Mass Index; D004734:Energy Metabolism / Q000502:physiology*; D004967:Estrogens / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008593:Menopause / Q000378:metabolism; D051379:Mice; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen; D001141:Aromatase