Trends in frequency and in vitro antifungal susceptibility patterns of Candida isolates from women attending the STD outpatients clinic of a tertiary care hospital in Northern Italy during the years 2002-2007.
Vulvovaginal candidiasis is a common mucosal infection caused by saprophytic and opportunistic yeasts belonging to the Candida genus. 518 vaginal swabs, with positive fungal culture were collected from unselected women attending the Sexually Transmitted Disease clinic of an Italian tertiary care hospital over a six year period to determine the pathogen prevalence in vulvovaginal candidiasis and to evaluate in vitro the antifungal susceptibilities of yeast recovered by Sensititre YeastOne antifungal panel plates according to CLSI document M27-A2. The isolates belonging to the genus Candida were 495 (95.5%) with Candida albicans percentage equal to 61.2%. Voriconazole was highly active (MIC50 0.008; MIC90 0.5 microg/ml), regardless of the species tested. On the contrary, fluconazole susceptibility was based upon the species. The intrinsic resistance to fluconazole of C. krusei was confirmed.
Asticcioli
Sara
S
Department of Morphological, Eidological and Clinical Sciences, Section of Microbiology, University of Pavia, Italy. sara.asticcioli@unipv.it
Sacco
Laura
L
Daturi
Rossana
R
Matti
Cecilia
C
Nucleo
Elisabetta
E
Zara
Francesca
F
Pagani
Laura
L
D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002181:Candidiasis, Vulvovaginal / Q000453:epidemiology* / Q000382:microbiology* / Q000517:prevention & control; D025141:Drug Resistance, Fungal; D005260:Female; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D010044:Outpatient Clinics, Hospital; D015995:Prevalence; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D012008:Recurrence; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use; D014621:Vagina / Q000382:microbiology; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D015725:Fluconazole; D065819:Voriconazole