Biological properties of carbon/carbon implant composites with unique manufacturing processes.
The goal was to manufacture carbon/carbon (C/C) composites through a unique procedure with improved biocompatibility and reduced debris release. C/C composites were prepared by chemical vapor deposition, and their biological properties were analyzed. With regard to mechanical properties, compressive strength/modulus was 219.1 MPa/9.72 GPa, flexural strength/modulus was 121.63 MPa/21.9 GPa, and interlaminar sheer was 15.13 GPa. Biocompatibility testing revealed: (1) the extract liquid from the C/C composites had no effect on cell proliferation; (2) the extract had no impact on micronucleus frequency as compared with the control groups (P > 0.05); (3) in vivo, there was mild tissue inflammation after implantation within the first 2 weeks, but there was no significant difference compared with the control group (P > 0.05); (4) the implants were well integrated into the host tissue, and debris was limited. The tested samples have excellent biocompatibilities and reduced release of debris. The demonstrated changes in manufacturing procedures are promising.
Wang
Guo-Hui
GH
Transplantation Medical Academy, Third XiangYa Hospital, Central South University, Changsha, People's Republic of China.
Yu
Shu
S
Zhu
Shai-Hong
SH
Gao
Chang-Qing
CQ
Liu
Yong
Y
Miu
Yun-Liang
YL
Huang
Bo-Yun
BY
D000818:Animals; D001672:Biocompatible Materials; D002244:Carbon / Q000737:chemistry*; D002460:Cell Line; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D005434:Flow Cytometry; D008297:Male; D008420:Manufactured Materials; D051379:Mice; D015162:Micronucleus Tests; D011817:Rabbits; D012867:Skin / Q000166:cytology
D001672:Biocompatible Materials; D002244:Carbon