title: Effects of high cholesterol diet on newly generated cells in the dentate gyrus of C57BL/6N and C3H/HeN mice.
abstract: In this study, we observed and compared the effects of a high cholesterol diet (HCD) on cell proliferation and differentiation in the subgranular zone of the dentate gyrus of C57BL/6N (B6, susceptible strain) and C3H/HeN (C3H, resistant strain) mice. Ki67 (a marker for cell proliferation) positive cells) were significantly decreased in HCD-fed B6 mice compared to those in B6 (49.7%) and C3H mice fed a low cholesterol diet (LCD). In addition, doublecortin (DCX, a marker for cell differentiation or neuroblasts)-immunoreactive cells in HCD-fed B6 mice were significantly decreased compared to those in LCD-fed B6 and C3H mice. These results suggest that B6 strains are sensitive to HCD, which impairs cell proliferation and differentiation.
authors: Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, South Korea.
authors: Il Yong
authors: IY
authors: Kim
authors: In Koo
authors: IK
authors: Hwang
authors: Ji Won
authors: JW
authors: Choi
authors: Ki-Yeon
authors: KY
authors: Yoo
authors: Yo Na
authors: YN
authors: Kim
authors: Sun Shin
authors: SS
authors: Yi
authors: Moo-Ho
authors: MH
authors: Won
authors: In Se
authors: IS
authors: Lee
authors: Yeo Sung
authors: YS
authors: Yoon
authors: Je Kyung
authors: JK
authors: Seong
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000378:metabolism; D018891:Dentate Gyrus / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D000089622:Doublecortin Domain Proteins; D000089662:Doublecortin Protein; D005260:Female; D006937:Hypercholesterolemia / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D055495:Neurogenesis / Q000502:physiology; D009479:Neuropeptides / Q000378:metabolism
chemical_list: D002791:Cholesterol, Dietary; C000714847:Dcx protein, mouse; D000089622:Doublecortin Domain Proteins; D000089662:Doublecortin Protein; D019394:Ki-67 Antigen; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides