Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis ameliorated by folate supplement.
A 62-year-old male with a 10-year history of seropositive rheumatoid arthritis (RA) developed gynecomastia 8 months after beginning oral low-dose methotrexate (MTX) therapy. Two months after folate supplementation, the gynecomastia symptoms improved. Gynecomastia associated with low-dose MTX is a rare occurrence, with only nine cases previously reported in the literature. This is the first report showing folate supplementation to be effective against gynecomastia following low-dose MTX. Although it occurs infrequently, gynecomastia associated with low-dose MTX therapy should be considered in male patients with RA.
Fukushi
Jun-ichi
J
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Fukuoka, 812-8582, Japan. fukushi@med.kyushu-u.ac.jp
Nakashima
Yasuharu
Y
Iwamoto
Yukihide
Y
D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005492:Folic Acid / Q000008:administration & dosage*; D006177:Gynecomastia / Q000139:chemically induced / Q000178:diet therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008327:Mammography; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000008:administration & dosage*
D018501:Antirheumatic Agents; D014803:Vitamin B Complex; D005492:Folic Acid; D008727:Methotrexate