title: Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.
abstract: Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2Rgamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc1.
authors: ID CEDD Diseases of the Developing World, GlaxoSmithKline, c/Severo Ochoa 2, 28760, Tres Cantos, Spain.
authors: María Belén
authors: MB
authors: Jiménez-Díaz
authors: Teresa
authors: T
authors: Mulet
authors: Sara
authors: S
authors: Viera
authors: Vanessa
authors: V
authors: Gómez
authors: Helen
authors: H
authors: Garuti
authors: Javier
authors: J
authors: Ibáñez
authors: Angela
authors: A
authors: Alvarez-Doval
authors: Leonard D
authors: LD
authors: Shultz
authors: Antonio
authors: A
authors: Martínez
authors: Domingo
authors: D
authors: Gargallo-Viola
authors: Iñigo
authors: I
authors: Angulo-Barturen
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins / Q000627:therapeutic use; D000077332:Artesunate; D002738:Chloroquine / Q000627:therapeutic use; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D053631:Interleukin Receptor Common gamma Subunit / Q000235:genetics / Q000502:physiology*; D007700:Kinetics; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000503:physiopathology; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D011728:Pyridones / Q000627:therapeutic use; D011739:Pyrimethamine / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D053631:Interleukin Receptor Common gamma Subunit; D011728:Pyridones; C534143:4-pyridone; D000077332:Artesunate; D002738:Chloroquine; D011739:Pyrimethamine