title: Calculating cumulative live-birth rates from linked cycles of assisted reproductive technology (ART): data from the Massachusetts SART CORS.
abstract: OBJECTIVE
  To determine the feasibility of linking assisted reproductive technology (ART) cycles for individual women to compare per-cycle and cumulative live-birth rates.
  
  
  METHODS
  Historical cohort study.
  
  
  METHODS
  Clinic-based data.
  
  
  METHODS
  A total of 27,906 ART cycles with residency or treatment in Massachusetts during 2004-2006 and reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) on-line database.
  
  
  METHODS
  None.
  
  
  METHODS
  Per-cycle and cumulative live-birth rates.
  
  
  RESULTS
  Linkage of cycles up to and including the first live-birth delivery revealed 14,265 women who averaged 1.9+/-1.2 SD cycles (range 1-11). These cycles yielded 9,452 pregnancies resulting in 7,675 live-birth deliveries. From cycle 1 to cycle 4, the cumulative live-birth rate for all patients increased from 30.4% to 43.3%, 49.1%, and 51.9%, respectively, and plateaued thereafter at about 53%. The cumulative live-birth rate after three cycles using donor oocytes was approximately 60% for women aged<43 years and >50% for women>or=43 years; for autologous oocytes it was 60.1% for ages<35 years and declined steadily to 8.5% for ages>or=43 years.
  
  
  CONCLUSIONS
  The results demonstrate the feasibility of linking ART cycles for individual women from SART CORS to characterize cumulative live-birth rates.
authors: Department of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire. Electronic address: judy.e.stern@dartmouth.edu.
authors: Judy E
authors: JE
authors: Stern
authors: Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
authors: Morton B
authors: MB
authors: Brown
authors: Department of Obstetrics, Gynecology, and Reproductive Biology and Department of Epidemiology, Michigan State University, East Lansing, Michigan.
authors: Barbara
authors: B
authors: Luke
authors: Redshift Technologies, New York, New York.
authors: Ethan
authors: E
authors: Wantman
authors: Redshift Technologies, New York, New York.
authors: Avi
authors: A
authors: Lederman
authors: Department of Obstetrics and Gynecology, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
authors: Stacey A
authors: SA
authors: Missmer
authors: Center for Reproductive Medicine, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts.
authors: Mark D
authors: MD
authors: Hornstein
mesh_terms: D000328:Adult; D000465:Algorithms; D016208:Databases, Factual; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016247:Information Storage and Retrieval; D050498:Live Birth / Q000453:epidemiology*; D008404:Massachusetts / Q000453:epidemiology; D008597:Menstrual Cycle / Q000502:physiology; D015233:Models, Statistical; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D013997:Time Factors; D016896:Treatment Outcome