A minimally invasive microdevice for molecular sampling and analysis.
In this paper, we present a new minimally invasive biopsy microdevice adapted to proteomic mass spectrometry analysis. The concept is born from a multidisciplinary collaboration in fields of proteomics, cancer research, and microtechnology. In mixing different skills, we have developed and manufactured a miniaturized biopsy device using microtechnology techniques in order to minimize tissue damage during surgical gesture. Dedicated chemically functionalized areas were added to the device in order to increase capture yield and specificity during tissue contact. Fields of application range from cancer research to the study of neurodegenerative diseases.
Cosnier
Marie-Line
ML
Electronics and Information Technology Laboratory of the French Atomic Energy Commission Micro-Nano Technologies(CEA-LETI-MINATEC), 38054 Grenoble, France. marieline.cosnier@cea.fr
Martin
Franck
F
Bouamrani
Ali
A
Berger
François
F
Caillat
Patrice
P
D001704:Biopolymers / Q000032:analysis*; D001706:Biopsy / Q000295:instrumentation*; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D046228:Microarray Analysis / Q000295:instrumentation*; D008904:Miniaturization; D019060:Minimally Invasive Surgical Procedures / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D046888:Tissue Array Analysis / Q000295:instrumentation*
D001704:Biopolymers