Simple and rapid voltammetric determination of morphine at electrochemically pretreated glassy carbon electrodes.
A simple and rapid method for morphine detection has been described based on electrochemical pretreatment of glassy carbon electrode (GCE) which was treated by anodic oxidation at 1.75 V, following potential cycling in the potential range from 0 V to 1.0 V vs. Ag|AgCl reference electrode. The sensitivity for morphine detection was improved greatly and the detection limit was 0.2 microM. The reproducibility of the voltammetric measurements was usually less than 3% RSD for six replicate measurements. Moreover, this method could readily discriminate morphine from codeine. And an electrochemical detection of morphine in spiked urine sample was succeeded with satisfactory results.
Li
Fei
F
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, and Graduate University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, PR China.
Song
Jixia
J
Gao
Dongmei
D
Zhang
Qixian
Q
Han
Dongxue
D
Niu
Li
L
D000327:Adsorption; D002138:Calibration; D002244:Carbon / Q000737:chemistry*; D003061:Codeine / Q000032:analysis; D004563:Electrochemistry; D004566:Electrodes; D005898:Glass / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009020:Morphine / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D013499:Surface Properties; D013997:Time Factors
D002244:Carbon; D009020:Morphine; D003061:Codeine