Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis.
Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection.
Mann
Francis M
FM
Iowa State University, Department of Biochemistry, Biophysics, and Molecular Biology, Ames, Iowa 5001, USA.
Xu
Meimei
M
Chen
Xiaoming
X
Fulton
D Bruce
DB
Russell
David G
DG
Peters
Reuben J
RJ
D003500:Cyclization; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D007700:Kinetics; D009169:Mycobacterium tuberculosis / Q000737:chemistry*; D010588:Phagosomes / Q000187:drug effects / Q000378:metabolism
D004224:Diterpenes; C547162:edaxadiene