Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs are believed to be related to mutational activation of receptor tyrosine kinases, KIT, or platelet-derived growth factor receptor-alpha. The coexistence of GISTs with other neoplasms has been extensively addressed in the literature. The most common second neoplasms are colorectal cancer, prostate cancer, and neoplasms derived from lymphoid tissue. In this case report, we describe a patient affected by GIST and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. The clinicopathological characteristics of the patient are discussed and the literature is reviewed.
Sonmez
Mehmet
M
Department of Hematology, Karadeniz Technical University School of Medicine, Trabzon, Turkey. mesonmez@yahoo.com
Arslan
Mehmet
M
Cobanoglu
Umit
U
Kavgaci
Halil
H
Ozbas
Hasan Mucahit
HM
Aydin
Fazil
F
Ovali
Ercument
E
Omay
Serdar Bedii
SB
D000368:Aged; D000753:Anemia, Refractory / Q000209:etiology* / Q000473:pathology; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000150:complications* / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000473:pathology