title: Antimalarial activity of tigecycline, a novel glycylcycline antibiotic.
abstract: Tigecycline is a novel glycylcycline antibiotic with a broad antibacterial spectrum. Tigecycline was tested with 66 clinical isolates of Plasmodium falciparum from Bangladesh using the histidine-rich protein 2 in vitro drug susceptibility assay. The 50% and 90% inhibitory concentrations of tigecycline were 699 (95% confidence interval, 496 to 986) and 5,905 nM (4,344 to 8,028). Tigecycline shows no activity correlation with traditional antimalarials and has substantial antimalarial activity on its own.
authors: Department of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
authors: P
authors: P
authors: Starzengruber
authors: K
authors: K
authors: Thriemer
authors: R
authors: R
authors: Haque
authors: W A
authors: WA
authors: Khan
authors: H P
authors: HP
authors: Fuehrer
authors: A
authors: A
authors: Siedl
authors: V
authors: V
authors: Hofecker
authors: B
authors: B
authors: Ley
authors: W H
authors: WH
authors: Wernsdorfer
authors: H
authors: H
authors: Noedl
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D004318:Doxycycline / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D013752:Tetracycline / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology*; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D013754:Tetracyclines; C087533:CL 331002; D000078304:Tigecycline; D013752:Tetracycline; D008911:Minocycline; D004318:Doxycycline