Immunosuppressive therapy in glomerular diseases: major accomplishment of Tadeusz Orłowski and his school.
Glomerulopathies are the third most common cause of end-stage renal failure. Immunosuppressive treatment of glomerulonephritis in a systematic way was introduced in Poland by Professor Tadeusz Orłowski in the early 1960s. The studies were conducted at the First Department of Medicine and at the Transplantation Institute of the Medical Academy in Warsaw in the years 1962-1988. This paper critically reviews the results of studies on the use of combined, triple-drug (prednisone/chlorambucil/azathioprine), immunosuppressive protocol in various pathological forms of glomerulopathies. We conclude that immunosuppressive protocols pioneered by Tadeusz Orłowski continue to be the backbone of the treatment of glomerulonephritis, especially the one with nephrotic syndrome, progressive impairment of kidney function and poor prognosis.
Smogorzewski
Mirosław J
MJ
Division of Nephrology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States. smogorze@usc.edu
Lao
Mieczysław
M
Gradowska
Liliana
L
Rowińska
Danuta
D
Rancewicz
Zofia
Z
D005921:Glomerulonephritis / Q000266:history* / Q000601:surgery; D049673:History, 20th Century; D006801:Humans; D007166:Immunosuppressive Agents / Q000266:history*; D007676:Kidney Failure, Chronic / Q000266:history* / Q000601:surgery; D016030:Kidney Transplantation / Q000266:history*; D009398:Nephrology / Q000266:history; D011044:Poland; D014495:Universities / Q000266:history
D007166:Immunosuppressive Agents