title: Early effects of oral administration of lafutidine with mosapride compared with lafutidine alone on intragastric pH values.
abstract: BACKGROUND
  The ideal medication for treatment of acid related diseases should have a rapid onset of action to promote hemostasis and resolution of symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion after a single oral administrations of lafutidine, is a newly synthesized H2-receptor antagonist, with mosapride 5 mg or lafutidine alone.
  
  
  METHODS
  Ten Helicobacter pylori negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 4 hours after a single oral administration of lafutidine 10 mg or lafutidine 10 mg with mosapride 5 mg (the lafutidine being administrated one hour after the mosapride). Each administration was separated by a 7-day washout period.
  
  
  RESULTS
  The average pH during the 4-hour period after administration of lafutidine 10 mg with mosapride 5 mg was higher than after lafutidine 10 mg alone (median: 5.25 versus 4.58, respectively; p = 0.0318). During the 3-4 hour study period, lafutidine 10 mg with mosapride 5 mg provided a higher pH, compared to lafutidine 10 mg alone (median: 7.28 versus 6.42; p = 0.0208).
  
  
  CONCLUSIONS
  In H. pylori negative healthy male subjects, an oral dose of lafutidine 10 mg with mosapride 5 mg more rapidly increased intragastric pH than lafutidine 10 mg alone.
authors: Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. hiro19780905@yahoo.co.jp
authors: Hiroshi
authors: H
authors: Iida
authors: Masahiko
authors: M
authors: Inamori
authors: Yuichi
authors: Y
authors: Nozaki
authors: Hiroki
authors: H
authors: Endo
authors: Kunihiro
authors: K
authors: Hosono
authors: Tomoyuki
authors: T
authors: Akiyama
authors: Yasunari
authors: Y
authors: Sakamoto
authors: Hirokazu
authors: H
authors: Takahashi
authors: Tomoko
authors: T
authors: Koide
authors: Chikako
authors: C
authors: Tokoro
authors: Yasunobu
authors: Y
authors: Abe
authors: Atsushi
authors: A
authors: Nakajima
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001549:Benzamides / Q000008:administration & dosage / Q000494:pharmacology*; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology*; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000081:Acetamides; D000897:Anti-Ulcer Agents; D001549:Benzamides; D006635:Histamine H2 Antagonists; D009025:Morpholines; D010880:Piperidines; D011725:Pyridines; C076948:lafutidine; C062720:mosapride