Glucose ingestion during endurance training in men attenuates expression of myokine receptor.
Glucose ingestion during exercise attenuates the release of the myokine interleukin-6 (IL-6) from working skeletal muscle, which results in a diminished increase in plasma IL-6. Interleukin-6 receptor alpha (IL-6Ralpha) expression in skeletal muscle is induced by acute exercise, mediated in part by an increased IL-6 concentration in the bloodstream. We hypothesized that endurance training would increase the density of IL-6Ralpha in skeletal muscle and that glucose ingestion would attenuate the effect. Nine subjects performed 10 weeks of one-legged knee-extensor training. They trained one leg (Glc-leg) while ingesting a glucose solution (Glc) and ingested a placebo (Plc) while training the other leg (Plc-leg). Endurance training increased peak power by 14% and reduced the exercise-induced gene expression of IL-6 and IL-6Ralpha in skeletal muscle and IL-6 plasma concentration. The IL-6Ralpha density increased to a lesser extent in the Glc-leg, suggesting that glucose ingestion attenuates the effect of training on IL-6Ralpha by blunting the IL-6 response. We conclude that glucose ingestion during endurance training attenuates the increase in IL-6Ralpha density.
Akerstrom
Thorbjorn C A
TC
The Centre of Inflammation and Metabolism and Copenhagen Muscle Research Centre, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark. thorbjorn_akerstrom@inflammation-metabolism.dk
Krogh-Madsen
Rikke
R
Petersen
Anne Marie Winther
AM
Pedersen
Bente Klarlund
BK
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D001642:Bicycling / Q000502:physiology; D015153:Blotting, Western; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D053698:Interleukin-6 Receptor alpha Subunit / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D010807:Physical Endurance / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055815:Young Adult
D015850:Interleukin-6; D053698:Interleukin-6 Receptor alpha Subunit; D012333:RNA, Messenger; D005947:Glucose