Translocation (1;10)(p34;p15) in infant acute myeloid leukemia with extramedullary infiltration in multiple sites.
Primary acute myeloid leukemia (AML) with extramedullary infiltration (EMI) in multiple sites is rare. Herein, we describe a case of infant AML with EMI in multiple sites. She had dyspnea and hypofibrinogenemia at diagnosis, and systemic computed tomography revealed EMI in the orbit, gingiva, bronchial pathway, and urinary tract. Bone marrow examination confirmed the diagnosis of AML with t(1;10)(p34;p15). No case of AML with t(1;10)(p34;p15) has been reported in the literature. At the present time, she remains free of disease 12 months after bone marrow transplantation (BMT) in the second complete remission.
Funato
Michinori
M
Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1-1, Gifu, Japan.
Fukao
Toshiyuki
T
Sasai
Hideo
H
Hori
Tomohiro
T
Terazawa
Daisuke
D
Ozeki
Michio
M
Orii
Kenji
K
Teramoto
Takahide
T
Kaneko
Hideo
H
Kondo
Naomi
N
D001853:Bone Marrow / Q000473:pathology; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics*; D017254:Leukemic Infiltration / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics*; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic