The effect of dl-, l- and d-propranolol on central monoamine neurones II. Studies on noradrenaline mechanisms.
l-Propranolo (20 mg/kg) reduced noradrenaline (NA) turnover in the cortex cerebri, rest of the brain, and periventricular posterior hypothalamus, whereas d-propranolol (20 mg/kg) increased NA turnover in the two former regions. The effects of l-propranolol on NA turnover could not be related to effects on NA uptake and release or to effects on NA receptor sites. l-Propranolol may reduce NA turnover by acting as an adrenaline agonist on adrenaline receptors located on the dendrites and cell bodies of the NA neurones. The antihypertensive action of l- and dl-propranolol may also involve an activation of adrenaline receptors inter alia those on the NA cells.
Fuxe
K
K
Department of Histology, Karolinska Institute, Stockholm Sweden; Department of Human Physiology, University of Bologna Italy; Department of Anatomy, University of Cambridge, Cambridge Great Britain.
Bolme
P
P
Agnati
L
L
Everitt
B J
BJ