Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions.
Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tablets from solid dispersions. The physical state and drug:carrier interactions were analyzed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration.
Lamas
Maria Celina
MC
Departamento Farmacia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina. mlamas@fbioyf.unr.edu.ar
Leonardi
Darío
D
Lambri
Osvaldo A
OA
Bassani
Georgina
G
Barrera
María G
MG
Bolmaro
Raúl E
RE
Salomon
Claudio J
CJ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D004008:Diclofenac / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D013607:Tablets; D004008:Diclofenac; D011205:Povidone