Nanopore with Transverse Nanoelectrodes for Electrical Characterization and Sequencing of DNA.
A DNA sequencing device which integrates transverse conducting electrodes for the measurement of electrode currents during DNA translocation through a nanopore has been nanofabricated and characterized. A focused electron beam (FEB) milling technique, capable of creating features on the order of 1 nm in diameter, was used to create the nanopore. The device was characterized electrically using gold nanoparticles as an artificial analyte with both DC and AC measurement methods. Single nanoparticle/electrode interaction events were recorded. A low-noise, high-speed transimpedance current amplifier for the detection of nano to picoampere currents at microsecond time scales was designed, fabricated and tested for future integration with the nanopore device.
Gierhart
Brian C
BC
Department of Electrical and Computer Engineering, University of California, Davis, One Shields Avenue, Davis, California.
Howitt
David G
DG
Chen
Shiahn J
SJ
Zhu
Zhineng
Z
Kotecki
David E
DE
Smith
Rosemary L
RL
Collins
Scott D
SD