title: Getting to first base in proteasome assembly.
abstract: Assembly of complex structures such as the eukaryotic 26S proteasome requires intricate mechanisms that ensure precise subunit arrangements. Recent studies have shed light on the pathway for ordered assembly of the base of the 19S regulatory particle of the 26S proteasome by identifying new precursor complexes and four dedicated chaperones involved in its assembly.
authors: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors: Henrike C
authors: HC
authors: Besche
authors: Andreas
authors: A
authors: Peth
authors: Alfred L
authors: AL
authors: Goldberg
mesh_terms: D000818:Animals; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D021122:Protein Subunits / Q000378:metabolism
chemical_list: D018832:Molecular Chaperones; D021122:Protein Subunits; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease; C119011:26S proteasome non-ATPase regulatory subunit 13