title: A novel polymorphism of GDF5 gene and its association with body measurement traits in Bos taurus and Bos indicus breeds.
abstract: Body measurement traits, influenced by genes and environmental factors, play numerous important roles in the value assessment of productivity and economy. Growth differentiate factor 5 (GDF5), involved in the development and maintenance of bone and cartilage, is an important candidate gene for body measurement traits selection through marker-assisted selection (MAS). In this study, based on the PCR-RFLP technology, we discovered and evaluated the potential association of the single nucleotide polymorphism (SNP) (T586C in exon 1) of the bovine GDF5 gene with body measurement traits in 985 Bos taurus breed, 42 Bos indicus breed and 76 Bos indicus x Bos taurus individuals. As the SNP marker, there were the significant effects on the Body length (BL) in the Bos taurus (BT) and Bos indicus x Bos taurus (BMY) populations (P < 0.05). In BT population, animals with the genotype TT had lower mean values for BL and Hip width (HW) than these with the TC and CC genotype (P < 0.01). In BMY population, animals with the genotype TC had lower mean values for BL than these with the genotype CC (P < 0.05). These results suggest that the SNP of the GDF5 gene could be a very useful genetic marker for body measurement traits in the bovine reproduction and breeding.
authors: College of Animal Science and Technology, Northwest A & F University, Shaanxi, People's Republic of China. yongfeng200@yahoo.com.cn
authors: Yong Feng
authors: YF
authors: Liu
authors: Lin Sen
authors: LS
authors: Zan
authors: Kui
authors: K
authors: Li
authors: Shuan Ping
authors: SP
authors: Zhao
authors: Ya Ping
authors: YP
authors: Xin
authors: Qing
authors: Q
authors: Lin
authors: Wan Qiang
authors: WQ
authors: Tian
authors: Zhi Wei
authors: ZW
authors: Wang
mesh_terms: D000818:Animals; D001483:Base Sequence; D001699:Biometry; D001947:Breeding; D002417:Cattle / Q000033:anatomy & histology* / Q000235:genetics*; D004252:DNA Mutational Analysis; D004587:Electrophoresis, Agar Gel; D005787:Gene Frequency / Q000235:genetics; D056426:Genetic Loci / Q000235:genetics; D005828:Genetics, Population; D055428:Growth Differentiation Factor 5 / Q000235:genetics*; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019655:Quantitative Trait, Heritable
chemical_list: D055428:Growth Differentiation Factor 5