title: Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning.
abstract: Although feedforward inhibition onto Purkinje cells was first documented 40 years ago, we understand little of how inhibitory interneurons contribute to cerebellar function in behaving animals. Using a mouse line (PC-Deltagamma2) in which GABA(A) receptor-mediated synaptic inhibition is selectively removed from Purkinje cells, we examined how feedforward inhibition from molecular layer interneurons regulates adaptation of the vestibulo-ocular reflex. Although impairment of baseline motor performance was relatively mild, the ability to adapt the phase of the vestibulo-ocular reflex and to consolidate gain adaptations was strongly compromised. Purkinje cells showed abnormal patterns of simple spikes, both during and in the absence of evoked compensatory eye movements. On the basis of modeling our experimental data, we propose that feedforward inhibition, by controlling the fine-scale patterns of Purkinje cell activity, enables the induction of plasticity in neurons of the cerebellar and vestibular nuclei.
authors: Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK.
authors: Peer
authors: P
authors: Wulff
authors: Martijn
authors: M
authors: Schonewille
authors: Massimiliano
authors: M
authors: Renzi
authors: Laura
authors: L
authors: Viltono
authors: Marco
authors: M
authors: Sassoè-Pognetto
authors: Aleksandra
authors: A
authors: Badura
authors: Zhenyu
authors: Z
authors: Gao
authors: Freek E
authors: FE
authors: Hoebeek
authors: Stijn
authors: S
authors: van Dorp
authors: William
authors: W
authors: Wisden
authors: Mark
authors: M
authors: Farrant
authors: Chris I
authors: CI
authors: De Zeeuw
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D002525:Cerebellar Cortex / Q000166:cytology / Q000502:physiology*; D007395:Interneurons / Q000166:cytology / Q000502:physiology; D007858:Learning / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009433:Neural Inhibition / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009924:Organ Culture Techniques; D011689:Purkinje Cells / Q000166:cytology / Q000502:physiology*; D011963:Receptors, GABA-A / Q000235:genetics; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D014726:Vestibular Nuclei / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid