Five new epothilone metabolites from Sorangium cellulosum strain So0157-2.
With the aim of identifying more novel natural epothilone derivatives produced by the epothilones A and B producing strain Sorangium cellulosum strain So0157-2, a large-scale fermentation (5000 l) of the strain was carried out. As a result, five new epothilone variants (1-5) were isolated from the fermentation broth. Their structures were established as 3-alpha-D-arabinofuranosides of epothilones A (1), B (2), D (3), C(9) (4) and 8-demethyl epothilone A (5) by extensive NMR analysis and chemical methods. Bioassay results showed that compounds 1 and 2 had a weaker cytotoxic activity than did epothilone B.
Wang
Jidong
J
Zhejiang Hisun Pharmaceutical Co. Ltd, Taizhou, Zhejiang, China.
Zhang
Hui
H
Ying
Linping
L
Wang
Chuanxi
C
Jiang
Nan
N
Zhou
Yue
Y
Wang
Haibin
H
Bai
Hua
H
D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D034261:Epothilones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D005285:Fermentation; D006801:Humans; D009231:Myxococcales / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D034261:Epothilones