title: Headaches in the different phases of relapsing-remitting multiple sclerosis: a tendency for stabbing headaches during relapses.
abstract: BACKGROUND
  Primary headaches are known to be associated with multiple sclerosis. We aimed to determine headaches using ICHD-II in different phases of relapsing-remitting multiple sclerosis, and the correlation between headaches and several features of the disease.
  
  
  RESULTS
  Migraine (41.2%) and tension-type headaches (20.6%) were the most common headaches in remission, and primary stabbing headache (PSH) (27.8%) was common in the relapsing phase. Although headaches seemed to occur independently of disease duration, extended disability status scale, beck depression inventory scores, and treatments, the total number of headaches was correlated with periventricular lesions (P = 0.03) and tension-type headaches were correlated with spinal lesions in remission (P = 0.02). Total number of headaches was correlated with brain stem lesions in the relapsing phase (P = 0.05).
  
  
  CONCLUSIONS
  The high frequency of PSHs in relapse was notable, and, to the best of our knowledge, PSH was not reported in relapsing-remitting multiple sclerosis before. Further studies with larger samples are recommended.
authors: Department of Neurology, Ankara Education and Research Hospital, Turkey. ufukergun@yahoo.com
authors: Ufuk
authors: U
authors: Ergün
authors: Gökhan
authors: G
authors: Ozer
authors: Sine
authors: S
authors: Sekercan
authors: Elif
authors: E
authors: Artan
authors: Ciğdem
authors: C
authors: Kudiaki
authors: Serap
authors: S
authors: Uçler
authors: Ozlem
authors: O
authors: Coşkun
authors: Levent
authors: L
authors: Inan
mesh_terms: D000328:Adult; D001933:Brain Stem / Q000473:pathology; D054022:Cerebrum / Q000473:pathology; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006261:Headache / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D009412:Nerve Fibers / Q000473:pathology; D009483:Neuropsychological Tests; D015995:Prevalence; D012008:Recurrence; D012720:Severity of Illness Index; D013116:Spinal Cord / Q000473:pathology; D018781:Tension-Type Headache / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult