title: Clinical outcomes of HIV-infected patients hospitalized with bacterial community-acquired pneumonia.
abstract: BACKGROUND
  There are limited and conflicting data on clinical outcomes of community-acquired pneumonia (CAP) among HIV-infected patients.
  
  
  METHODS
  Secondary analyses of clinical outcomes of CAP were performed for 118 patients with HIV infection and 2790 patients without HIV infection enrolled in the Community-Acquired Pneumonia Organization (CAPO) international study. After adjustment for significant confounders, the effect of HIV infection on length of stay (LOS) and time to clinical stability (TCS) were examined by survival analyses and overall mortality and CAP-related mortality by logistic regression methods.
  
  
  RESULTS
  After adjusting for significant confounders, hospitalized HIV-infected patients with CAP did not have longer times to reach clinical stability (HR 1.126; 95% CI 0.917-1.391; p=0.251) or longer stays in the hospital (HR 1.191, 95% CI 0.979-1.449; p=0.080). In addition, HIV infection did not significantly influence overall mortality rates (OR 1.205, 95% CI 0.686-2.116; p=0.517) or CAP-related mortality rates (OR 1.338; 95% CI 0.623-3.725; p=0.355).
  
  
  CONCLUSIONS
  The presence of HIV infection did not influence the clinical outcomes of CAP among patients assessed at CAPO centers. It is not intended that our results be extrapolated to populations receiving limited healthcare for advanced HIV disease, malnourishment and parasitic diseases.
authors: Division of Infectious Disease, University of Louisville School of Medicine, Louisville, KY, USA.
authors: Maricar
authors: M
authors: Malinis
authors: John
authors: J
authors: Myers
authors: Jose
authors: J
authors: Bordon
authors: Paula
authors: P
authors: Peyrani
authors: Rama
authors: R
authors: Kapoor
authors: Raul
authors: R
authors: Nakamatzu
authors: Gustavo
authors: G
authors: Lopardo
authors: Antoni
authors: A
authors: Torres
authors: Charles
authors: C
authors: Feldman
authors: M
authors: M
authors: Allen
authors: F
authors: F
authors: Arnold
authors: Julio
authors: J
authors: Ramirez
mesh_terms: D000328:Adult; D017714:Community-Acquired Infections / Q000150:complications / Q000401:mortality / Q000628:therapy*; D005260:Female; D014943:Global Health; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007902:Length of Stay; D008297:Male; D017063:Outcome Assessment, Health Care; D018410:Pneumonia, Bacterial / Q000150:complications / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis