Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease.
Alzheimer's disease (AD) is a neurodegenerative disorder with a complex etiology and pathogenesis. Chromosome missegregation was proposed two decades ago to be responsible for neurodegeneration in AD patients. It was speculated that the aneuploidy is a result of aberrant cell cycle of neuronal progenitors during adult neurogenesis and/or of mature neurons. There is mounting evidence of increased rate of general aneuploidy and cell cycle reentry in the AD patients' brains, with area-specific pattern. In this review, we discuss the involvement of chromosome instability, genome damage and cell cycle impairment in AD pathology.
Zekanowski
Cezary
C
Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland. czarekz@cmdik.pan.pl.
Wojda
Urszula
U
D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000782:Aneuploidy; D000818:Animals; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D002453:Cell Cycle / Q000502:physiology*; D002875:Chromosomes / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016875:tau Proteins / Q000378:metabolism
D016229:Amyloid beta-Peptides; D016875:tau Proteins