A 14-year-old female patient with FIGO stage IB endometrial carcinoma: a case report.
BACKGROUND
This is the second report on the conservative treatment of endometrial carcinoma in a female patient younger than fifteen years. Case A, a 14-year-old teenager, presented with menorrhagia. An endometrial biopsy revealed grade 2 endometrioid adenocarcinoma. The estrogen receptor and progesterone receptor were strongly positive in 60% and 90% of the tumor, respectively. Although she was administered medroxyprogesterone acetate for a month, it was not effective. She underwent standard surgery including a hysterectomy. She was thereafter free of disease 1 year after surgery. No estrogen receptor staining of the surgical specimen was observed, and 30% of the tumor was strongly positive for progesterone receptor. Direct DNA sequencing of exons 7 and 8 of PTEN and the K-ras codon 12 demonstrated the presence of no mutation. In addition, no dominant-negative p53 mutation was found by a yeast functional assay.


CONCLUSIONS
A uterine malignancy should therefore be included in the differential diagnosis in a young female patient complaining of abnormal genital bleeding.
Mitamura
Takashi
T
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. pikarun2620@jcom.home.ne.jp
Watari
Hidemichi
H
Todo
Yukiharu
Y
Koshida
Takayuki
T
Sakuragi
Noriaki
N
D000293:Adolescent; D018269:Carcinoma, Endometrioid / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human