title: Variation in GRIN2B contributes to weak performance in verbal short-term memory in children with dyslexia.
abstract: A multi-marker haplotype within GRIN2B, a gene coding for a subunit of the ionotropic glutamate receptor, has recently been found to be associated with variation in human memory performance [de Quervain and Papassotiropoulos, 2006]. The gene locus is located within a region that has been linked to a phonological memory phenotype in a recent genome scan in families with dyslexia [Brkanac et al., 2008]. These findings may indicate the involvement of GRIN2B in memory-related aspects of human cognition. Memory performance is one of the cognitive functions observed to be disordered in dyslexia patients. We therefore investigated whether genetic variation in GRIN2B contributes to specific quantitative measures in a German dyslexia sample by genotyping 66 SNPs in its entire genomic region. We found supportive evidence that markers in intron 3 are associated with short-term memory in dyslexia, and were able to demonstrate that this effect is even stronger when only maternal transmission is considered. These results suggest that variation within GRIN2B may contribute to the genetic background of specific cognitive processes which are correlates of the dyslexia phenotype.
authors: Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.|Institute of Human Genetics, University of Bonn, Bonn, Germany.
authors: Kerstin U
authors: KU
authors: Ludwig
authors: Max-Planck Institute of Psychiatry, Munich, Germany.
authors: Darina
authors: D
authors: Roeske
authors: Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.|Institute of Human Genetics, University of Bonn, Bonn, Germany.
authors: Stefan
authors: S
authors: Herms
authors: Institute of Human Genetics, University of Bonn, Bonn, Germany.
authors: Johannes
authors: J
authors: Schumacher
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany.
authors: Andreas
authors: A
authors: Warnke
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany.
authors: Ellen
authors: E
authors: Plume
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany.
authors: Nina
authors: N
authors: Neuhoff
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany.
authors: Jennifer
authors: J
authors: Bruder
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
authors: Helmut
authors: H
authors: Remschmidt
authors: Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany.
authors: Gerd
authors: G
authors: Schulte-Körne
authors: Max-Planck Institute of Psychiatry, Munich, Germany.
authors: Bertram
authors: B
authors: Müller-Myhsok
authors: Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.|Institute of Human Genetics, University of Bonn, Bonn, Germany.
authors: Markus M
authors: MM
authors: Nöthen
authors: Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.|Institute of Human Genetics, University of Bonn, Bonn, Germany.
authors: Per
authors: P
authors: Hoffmann
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics; D002648:Child; D003072:Cognition Disorders / Q000235:genetics; D015897:Comorbidity; D004410:Dyslexia / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D007802:Language; D008297:Male; D008570:Memory, Short-Term; D011932:Reading; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*
chemical_list: C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate