[Research progress of hypoxia inducible factor 1alpha in hypoxic-ischemic injury].
OBJECTIVE
To review the role of hypoxia inducible factor 1alpha (HIF-1alpha) in hypoxic-ischemic injury and its repair, and to analyze the possible mechanisms.


METHODS
Recent literature on HIF-1alpha and its role in hypoxic-ischemic injury was reviewed and analyzed.


RESULTS
HIF-1alpha was involved in the hypoxic-ischemic injury of various organs or tissues and their repair processes.


CONCLUSIONS
HIF-1alpha has a potential to treat common clinical hypoxic-ischemic injuries and has a promising future for application.
Tang
Binzhi
B
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu Sichuan, 610041, PR China.
Qu
Yi
Y
Mu
Dezhi
D
D006801:Humans; D000860:Hypoxia; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007511:Ischemia
D051795:Hypoxia-Inducible Factor 1, alpha Subunit