title: Maternal HLA class I compatibility in patients with biliary atresia.
abstract: Biliary atresia (BA) is an inflammatory cholangiopathy of unknown etiology. Maternal microchimerism has been identified in the livers of patients with BA. We analyzed the human leukocyte antigen (HLA) compatibility between 57 BA patient-mother pairs and 50 control-mother pairs. The HLA class I matching was significantly more frequent in BA pairs (odds ratio [OR]=2.46) than controls. Similar results were also found in child-to-mother HLA compatibility (OR=2.16). Our results indicate that patients with BA have an immunogenetic histocompatible relationship with their mothers, which may result in an increase in maternal microchimerism found in BA.
authors: Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Naoki
authors: N
authors: Irie
authors: Toshihiro
authors: T
authors: Muraji
authors: Naoki
authors: N
authors: Hosaka
authors: Yasutsugu
authors: Y
authors: Takada
authors: Seisuke
authors: S
authors: Sakamoto
authors: Kohichi
authors: K
authors: Tanaka
mesh_terms: D001652:Bile Ducts; D001656:Biliary Atresia / Q000235:genetics* / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D046528:Chimerism; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D054502:Histocompatibility, Maternal-Fetal / Q000235:genetics*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D009035:Mothers; D016017:Odds Ratio; D010375:Pedigree
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I