title: Dimethyl sulfoxide-induced toxicity in cord blood stem cell transplantation: report of three cases and review of the literature.
abstract: Umbilical cord blood transplantation using nonmyeloablative conditioning is currently considered by many as a valid potential alternative for any patient who requires an unrelated donor allograft and who is without a suitably matched and readily available volunteer. Dimethyl sulfoxide (DMSO) has been used for years as a cryoprotectant agent; it acts by penetrating the cell and binding water molecules and it has been described as harmless for the individual who receives it in limited amounts. In this paper, we describe 3 cases of DMSO-induced toxicities and briefly review the most common adverse reactions of the DMSO when used as a cryopreservation agent for the long-term storage of cord blood cells. Two of the 3 cases had a dismal prognosis. A brief review of the literature is presented.
authors: Centro de Hematología y Medicina Interna de Puebla, Laboratorios Clinicos de Puebla, Puebla, México. gruiz2@clinicaruiz.com
authors: Guillermo J
authors: GJ
authors: Ruiz-Delgado
authors: Consuelo
authors: C
authors: Mancías-Guerra
authors: Edna L
authors: EL
authors: Tamez-Gómez
authors: Laura N
authors: LN
authors: Rodríguez-Romo
authors: Avril
authors: A
authors: López-Otero
authors: Ana
authors: A
authors: Hernández-Arizpe
authors: David
authors: D
authors: Gómez-Almaguer
authors: Guillermo J
authors: GJ
authors: Ruiz-Argüelles
mesh_terms: D018952:Antigens, CD34; D002648:Child; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D003451:Cryoprotective Agents / Q000009:adverse effects*; D004121:Dimethyl Sulfoxide / Q000009:adverse effects*; D005199:Fanconi Anemia / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male
chemical_list: D018952:Antigens, CD34; D003451:Cryoprotective Agents; D004121:Dimethyl Sulfoxide