title: [Features of insulin secretion and insulin resistance in newly diagnosed type 2 diabetes of different body mass indices].
abstract: OBJECTIVE
  To investigate insulin secretion function and insulin resistance in Chinese newly diagnosed type 2 diabetes (obese and non-obese patients) in order to provide evidence for clinical treatment.
  
  
  METHODS
  408 newly diagnosed type 2 diabetes and 40 normal controls were recruited. Height, weight were measured, insulin and glucose of 0 min, 30 min, 60 min, 120 min during oral glucose tolerance test were examined. The patients with fasting glucose level greater than 8.3mmol/L were treatment with Gliclazide for 1 - 3 months. After normalization of the plasma glucose levels for more than 2 weeks, and withdraw this medication for 48 hours, then OGTT were repeated to assess IR and IS.
  
  
  RESULTS
  The patients were divided into four groups based on fasting plasma glucose (DM1: FPG < 6.9mmol/L; DM2: 6.9 mmol/L < or = FPG < 8.3 mmol/L; DM3: 8.3 mmol/L < or = FPG < 9.7 mmol/L; DM4: FPG > or = 9.7 mmol/L). Every groups were further stratified to subgroups by cut point of BMI = 24 kg/m(2). Their insulin sensitivity and insulin secretion function compared between subgroups. (1) True insulin level in BMI > or = 24 (FPG < 6.9 mmol/L) subgroups were higher than control's (3.5 +/- 0.5 vs 3.2 +/- 0.6 natural logarithm) (P < 0.05). (2) In BMI > or = 24 subgroups, their insulin sensitivity were even worse than BMI < 24 groups', but their insulin secretion function were better at the same FPG level. (3) After intervention, the change of insulin sensitivity in BMI < 24 group was better than BMI > or = 24 group's (-4.7 +/- 0.9 vs -5.5 +/- 1.4 natural logarithm) (P < 0.05); but the change of insulin secretion function in BMI < 24 group was worse.
  
  
  CONCLUSIONS
  (1) In newly diagnostic type 2 diabetes, insulin sensitivity and insulin secretion function were decreased with the increase of FPG, but they were different between obese and non-obese group. (2) Insulin secretion function was recovered better in obese group when eliminated glucose toxicity.
authors: Center for Endocrine and Metabolic Diseases, China-Japan friendship hospital, Peking Union Medical College, Beijing 100029, China.
authors: Ya-Li
authors: YL
authors: An
authors: Yan
authors: Y
authors: Gao
authors: Qian
authors: Q
authors: Zhu
authors: Guang
authors: G
authors: Ning
authors: Wei-Ping
authors: WP
authors: Jia
authors: Qin
authors: Q
authors: Huang
authors: Wen
authors: W
authors: Xu
authors: Cheng-Jiang
authors: CJ
authors: Li
authors: Zhi-Guang
authors: ZG
authors: Zhou
authors: Bing-Yin
authors: BY
authors: Shi
authors: Zhong-Yan
authors: ZY
authors: Shan
authors: Lu-Lu
authors: LL
authors: Chen
authors: Zhang-Rong
authors: ZR
authors: Xu
authors: Heng
authors: H
authors: Wang
authors: Li
authors: L
authors: Yan
authors: Hui-Ju
authors: HJ
authors: Zhong
authors: Qiu-He
authors: QH
authors: Ji
authors: Hong
authors: H
authors: Li
authors: Yuan-Ming
authors: YM
authors: Xue
authors: Mu-Xun
authors: MX
authors: Zhing
authors: Wei
authors: W
authors: Gu
authors: Xiao-Hui
authors: XH
authors: Guo
authors: Lei-Li
authors: LL
authors: Gao
authors: Jie
authors: J
authors: Hong
authors: Fang
authors: F
authors: Liu
authors: Da-Jin
authors: DJ
authors: Zou
authors: Yan-Bing
authors: YB
authors: Li
authors: Xiao-Ying
authors: XY
authors: Zhang
authors: Zhen
authors: Z
authors: Li
authors: Gui
authors: G
authors: Guo
authors: Xiao-Juan
authors: XJ
authors: Zhao
authors: Han-Ni
authors: HN
authors: Wu
authors: Yu-Zhen
authors: YZ
authors: Wang
authors: Wei-Gang
authors: WG
authors: Zhao
authors: Shao-Lin
authors: SL
authors: Zhang
authors: Jing
authors: J
authors: Wu
authors: Nan-Yan
authors: NY
authors: Zhang
authors: Feng-Ying
authors: FY
authors: Yang
authors: Yun
authors: Y
authors: Zhang
authors: Xin-Rong
authors: XR
authors: Zhou
authors: Yue-Zhong
authors: YZ
authors: Ren
authors: Guang-Wei
authors: GW
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D007328:Insulin