[Radio protective drug production from fresh leaves of Aloe arborescens Mill].
Nowadays, phytogenous drugs are wildly used as radio protective substances. The aim of the research was to study radio protective characteristics of aloe juice fraction and to develop new technology for radio protective drug production. Technological scheme for getting the drug in two stages. The first stage - extraction of juice from fresh leaves; the second stage - extracting bagasse have been developed and optimal environment for bagasse extraction are defined: Infusion of bagasse with 96 % ethyl spirit (1:1) during 30 minutes, continuation of extracting with water on correlation to raw materials 10:1 at temperature of 70 degrees C during 30 minutes. For the basis of the first series of balanced loading there are taken the optimal parameters of extracting process, on the basis of which in its turn was developed technological scheme of getting dry extract of aloe. Dry extract is a fine-dispersed reddish-yellow (brownish-yellow) powder, which can be easily dissolved in warm (40-60 degrees C) water. Pharmacological researches were conducted in the Institute of General and Experimental Biology, Siberian Branch, Russian. Academy of Sciences. The remarkable radio protective effect of the drug was revealed.
Bakuridze
A Dzh
AD
Nikolaev
S M
SM
Berashvili
D T
DT
Bakuridze
K A
KA
Tsomaia
I V
IV
D000504:Aloe / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013678:Technology, Pharmaceutical / Q000379:methods*
D010936:Plant Extracts; D011837:Radiation-Protective Agents