title: Response to treatment in women with chronic myeloid leukemia during pregnancy and after delivery.
abstract: Here we report response to treatment of chronic myeloid leukemia (CML) of five pregnant women during and after pregnancy. CML was diagnosed during pregnancy in three patients. Pregnancy was confirmed during CML in two patients: in one in the 21st week of pregnancy while on imatinib, in another in the 12th week during the interferon treatment. Interferon with leukapheresis when needed was applied in the 2nd and 3rd trimester. All patients except one achieved complete hematological response during pregnancy. After delivery four patients achieved partial cytogenetic response on imatinib and two patients achieved major molecular response after crossover to dasatinib.
authors: Institue of Hematology and Blood Transfusion, U Nemocnice 1, 12820 Prague, Czech Republic.
authors: Hana
authors: H
authors: Klamová
authors: Markéta
authors: M
authors: Marková
authors: Jana
authors: J
authors: Moravcová
authors: Magda
authors: M
authors: Sisková
authors: Petr
authors: P
authors: Cetkovský
authors: Katerina
authors: K
authors: Machová Poláková
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D000069439:Dasatinib; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D007372:Interferons / Q000627:therapeutic use; D007937:Leukapheresis; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000628:therapy*; D010879:Piperazines / Q000627:therapeutic use; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy / Q000628:therapy*; D011743:Pyrimidines / Q000627:therapeutic use; D013844:Thiazoles / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D013844:Thiazoles; D000068877:Imatinib Mesylate; D007372:Interferons; D000069439:Dasatinib