Effects of pentylenetetrazol on resting membrane potential and on action potentials of mammalian dorsal root ganglion cells grown in tissue culture.
The effects of pentylenetetrazol (PTZ) on resting membrane potential (RMP) and on action potentials (AP) of dorsal root ganglion cells of the rat in tissue culture were studied. PTZ usually evoked a hyperpolarization which was followed by a depolarization. The hyperpolarization diminished with increasing initial MP and was absent at about 80 mV. Latency and amplitude of the depolarization decreased and increased, respectively, when the PTZ concentration was raised. Paroxysmal depolarization shifts did not occur. AP generation was depressed independently from RMP fluctuations.
Bingmann
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Physiologisches Institut der Universität, Münster GFR.
Speckmann
E J
EJ
Pietruschka
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F