title: Novel thermal and microwave-assisted facile route to naphthalen-2(1H)-ones via an oxidative alkoxylation-ring-opening protocol.
abstract: Several novel 1,1-disubstituted-8-hydroxynaphthalen-2(1H)-ones have been efficiently synthesized via a two-step sequence from 2-hydroxy-1-naphthaldehyde oxime. The methodology involves oxidative ring closure and alkoxylation to 3a-alkoxynaphtho[1,8-de][1,2]oxazin-4(3aH)-ones, followed by thermal ring-opening. Both thermal and microwave irradiation conditions were used. A novel one-pot reaction of oxime to 8-isopropoxynaphthalene-1,7-diol using microwave irradiation is also reported.
authors: Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.
authors: Chrysanthi
authors: C
authors: Dolka
authors: Kristof
authors: K
authors: Van Hecke
authors: Luc
authors: L
authors: Van Meervelt
authors: Petros G
authors: PG
authors: Tsoungas
authors: Erik V
authors: EV
authors: Van der Eycken
authors: George
authors: G
authors: Varvounis
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D015394:Molecular Structure; D009284:Naphthols / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D010091:Oximes / Q000737:chemistry*
chemical_list: D009284:Naphthols; D010091:Oximes