Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention.
In this issue of Cell Metabolism, Kaufman and colleagues (Back et al., 2009) elegantly demonstrate that appropriate regulation of eIF2alpha phosphorylation improves glucose tolerance and beta cell viability by preventing the lethal buildup of oxidative damage due to unregulated synthesis, trafficking, and misfolding of proteins.
Wek
Ronald C
RC
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. rwek@iupui.edu
Anthony
Tracy G
TG
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000378:metabolism*; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D051379:Mice; D018384:Oxidative Stress; D010766:Phosphorylation
D000975:Antioxidants; D015852:Eukaryotic Initiation Factor-2