Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark.
Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity. Caryophyllene oxide at the doses of 12.5 and 25mg/kg body wt. and unsaponified petroleum ether extract at a dose of 50mg/kg body wt. showed significant central as well as peripheral analgesic, along with anti-inflammatory, activity. These activities of caryophyllene oxide were comparable with the standard drug used in the respective experiments.
Chavan
M J
MJ
Department of Pharmacognosy, Amrutvahini College of Pharmacy, Sangamner S.K. 422 608, Dist- Ahmednagar, M.S., India.
Wakte
P S
PS
Shinde
D B
DB
D019342:Acetic Acid; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D031041:Annona / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D006358:Hot Temperature; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000081223:Polycyclic Sesquiterpenes; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D002351:Carrageenan; D019342:Acetic Acid; C515179:caryophyllene oxide