Myelin composition in the central nervous system of mutant Han-Wistar rats.
Characterization of a Han-Wistar mutation (which is expressed as progressive spastic paresis in homozygotes) was extended to an analysis of myelin isolated from the brain, cerebellum and spinal cord of affected and littermate control rats. In all regions, the tissue content and protein composition of myelin from both groups of animals were similar, indicating that the synthesis of abnormal myelin is not the primary effect of this mutation.
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Max-Planck-Institut fur experimentelle Medizin, Forschungsstelle neurochemie and Abteilung biochemische Pharmakologie, 3400 Göttingen, G.F.R.
Neuhoff
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Sontag
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KH
Osborne
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