title: Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy.
abstract: OBJECTIVE
  To report an ultrastructurally distinct form of paraprotein crystalline keratopathy.
  
  
  METHODS
  Three corneas submitted from a single patient including one native cornea from each eye and a failed corneal graft from the right eye. Light microscopy, immunohistochemistry, immunofluorescence, and transmission electron microscopic examination were performed.
  
  
  RESULTS
  The transmission electron microscopy showed "immunotactoid" extracellular microtubular deposits measuring >30 nm in diameter with a central lucent core.
  
  
  CONCLUSIONS
  Immunotactoid keratopathy is a distinct type of paraprotein crystalline keratopathy associated with a monocolonal immunoglobulin G kappa light chain (IgGk) protein. Larger case series are needed to determine the clinical significance of this entity.
authors: Department of Pathology, Rhode Island Hospital and Miriam Hospital, Providence, RI 02903, USA. kamallabana@rediffmail.com
authors: Kamaljeet
authors: K
authors: Singh
mesh_terms: D000368:Aged; D003316:Corneal Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D003319:Corneal Stroma / Q000276:immunology / Q000473:pathology*; D016039:Corneal Transplantation; D006084:Graft Rejection; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007145:Immunoglobulin kappa-Chains / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000150:complications; D008297:Male; D010265:Paraproteinemias / Q000150:complications* / Q000276:immunology / Q000473:pathology
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains