Caloric restriction delays disease onset and mortality in rhesus monkeys.
Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.
Colman
Ricki J
RJ
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA. rcolman@primate.wisc.edu
Anderson
Rozalyn M
RM
Johnson
Sterling C
SC
Kastman
Erik K
EK
Kosmatka
Kristopher J
KJ
Beasley
T Mark
TM
Allison
David B
DB
Cruzen
Christina
C
Simmons
Heather A
HA
Kemnitz
Joseph W
JW
Weindruch
Richard
R
D000375:Aging; D000818:Animals; D001284:Atrophy / Q000453:epidemiology / Q000517:prevention & control; D001835:Body Weight; D001921:Brain / Q000473:pathology*; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D005947:Glucose / Q000378:metabolism; D015994:Incidence; D008136:Longevity; D008253:Macaca mulatta; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000517:prevention & control*
D005947:Glucose