title: Changes in microcirculation as early markers for infection in preterm infants--an observational prospective study.
abstract: In adults with severe sepsis, the disturbances of the sublingual microcirculation can be quantified with orthogonal polarization spectral imaging. We investigated the cutaneous microcirculation of preterm infants with proven infection (PosInf) and with suspected but unproven infection (NegInf). In 25 infants, orthogonal polarization spectral images were obtained daily, videos of the images were blinded, and analyzed off-line. Functional small vessel density (FSVD) was prospectively calculated from day 3 to day 30 of life. There were 17 episodes of proven and nine episodes of suspected but unproven nosocomial late onset infection. Four infants remained healthy. The data were analyzed for the 5 d before the start of antibiotics (day -5 until day -1). FSVD varied widely, but in the PosInf-group, we found a 10% decline from day -5 to day -1 (p = 0.013). There was no significant change over time in the NegInf-group (p = 0.58). Thus, in infants with proven infection, FSVD decreases already 1 d before changes in laboratory parameters. However, these changes in FSVD during infection are not represented by absolute values, but must be identified by daily intraindividual observation.
authors: Department of Internal Medicine, General Hospital Munich, Munich Bavaria 80804, Germany.
authors: Kathrin
authors: K
authors: Weidlich
authors: Julia
authors: J
authors: Kroth
authors: Claudia
authors: C
authors: Nussbaum
authors: Stephan
authors: S
authors: Hiedl
authors: Andreas
authors: A
authors: Bauer
authors: Frank
authors: F
authors: Christ
authors: Orsolya
authors: O
authors: Genzel-Boroviczeny
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000378:metabolism*; D008833:Microcirculation; D011446:Prospective Studies; D012039:Regional Blood Flow; D018805:Sepsis / Q000097:blood*; D012867:Skin / Q000098:blood supply*
chemical_list: D015415:Biomarkers