title: Clinical neuropsychiatric correlates and EEG findings among children with developmental disorders in Lagos, Nigeria.
abstract: OBJECTIVE
  Developmental disorders with or without associated neuropsychiatric complications continue to be one of the major health problems in Africa. The grossly inadequate management/ rehabilitative facilities further worsen this. A prospective study aimed at finding the types of developmental disorders and associated neuropsychiatric complications among children aged </=15 years that presented with developmental disorder in the study centers over 36 month study duration.
  
  
  METHODS
  The study was carried out in the paediatric and child psychiatric clinics as well as the Electroencephalographic (EEG) unit of two major health facilities in Lagos, Nigeria: Lagos University Teaching Hospital (LUTH) and Psychiatric Hospital, Yaba, Lagos. For each subject, socio-demographic data was obtained and appropriate clinical evaluation was carried out to obtain the necessary data and clinical diagnoses. Furthermore, each of the subjects had waking EEG recording using 20-channel computerized Medelec(R)EEG machine. The EEG interpretation was blinded to the clinical history of the subjects.
  
  
  RESULTS
  Overall, one hundred and eleven (111) subjects were evaluated over the 36 month study period. The cohort was made up of 63 (56.8%) males and 48 (43.2%) females. The mean age was 4.8 (+/-3.9) years, with most subjects falling in the age group of 0-5 years(69.4%). Mixed specific developmental disorders were most common (55%) followed by that of specific developmental disorders of speech and language (34.2%). Forty-one (36.9%) subjects suffered from one or more types of complications, with seizure, 22(19.8%) being the most common. The waking EEG recording was normal in 22 (19.8%) subjects; while abnormal epileptiform activities were found in 85 (76.6%) of recordings. No statistically significant relationship existed between EEG abnormalities and the factors of age and clinical diagnoses (i.e developmental abnormalities).
  
  
  CONCLUSIONS
  The small number of subjects in this study is a major hindrance to drawing a general conclusion. However, it has been shown that a number of the cohort in addition to their developmental disorders suffered from such complications as seizures, hyperactivity etc. Furthermore, a significant proportion had EEG abnormalities of the epileptiform types possibly reinforcing the previously known fact of prevalent subtle brain damage among African children. The need for preventive health care is therefore emphasized.
authors: Department of Psychiatry, Department of Paediatrics, College of Medicine, University of Lagos, Lagos, Nigeria.
authors: O F
authors: OF
authors: Aina
authors: O C
authors: OC
authors: Ogun
authors: H T
authors: HT
authors: Ladapo
authors: F E
authors: FE
authors: Lesi
authors: O O
authors: OO
authors: Famuyiwa
mesh_terms: D002648:Child; D002658:Developmental Disabilities; D004569:Electroencephalography; D006778:Hospitals, Psychiatric; D006801:Humans; D009549:Nigeria; D011446:Prospective Studies