title: Spanish Society of Medical Oncology consensus for the use of haematopoietic colony-stimulating factors in cancer patients.
abstract: Neutropenia is a common complication of cancer chemotherapy. Colony-stimulating factors (CSF) may be used to avoid neutropenia-associated complications. The Spanish Society of Medical Oncology (SEOM) recently constituted a working group to review the main issues concerning the use of CSF and carried out a consensus process about the use of CSF in cancer patients, held in Madrid on 26 May 2006. The group concluded the following recommendations: prophylactic use of CSF is recommended when a rate of febrile neutropenia (FN) higher than 20% is expected without the use of CSF or when additional risk factors for neutropenia exist; therapeutic use of CSF is recommended in order to treat FN episodes but not to treat afebrile neutropenic episodes. In addition, the use of CSF is considered effective when used to mobilise stem cells before high-dose chemotherapy and when used for chemotherapy schedule optimisation in dose-dense and in dose-intense regimens.
authors: Medical Oncology Department, Ramón y Cajal University Hospital, Madrid, Spain. acarrato@telefonica.net
authors: Alfredo
authors: A
authors: Carrato
authors: Luis
authors: L
authors: Paz-Ares Rodríguez
authors: Alvaro
authors: A
authors: Rodríguez Lescure
authors: Ana M
authors: AM
authors: Casas Fernández de Tejerina
authors: Eduardo
authors: E
authors: Díaz Rubio García
authors: Pedro
authors: P
authors: Pérez Segura
authors: Manuel
authors: M
authors: Constenla Figueiras
authors: Rocío
authors: R
authors: García Carbonero
authors: José
authors: J
authors: Gómez Codina
authors: Ana
authors: A
authors: Lluch Hernández
authors: José Pablo
authors: JP
authors: Maroto Rey
authors: Miguel
authors: M
authors: Martín Jiménez
authors: José Ignacio
authors: JI
authors: Mayordomo Cámara
authors: José Andrés
authors: JA
authors: Moreno Nogueira
authors: Antonio
authors: A
authors: Rueda Domínguez
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D003115:Colony-Stimulating Factors / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008495:Medical Oncology; D009369:Neoplasms / Q000150:complications*; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control* / Q000652:urine; D013030:Spain
chemical_list: D003115:Colony-Stimulating Factors