Pineal effects upon pituitary protein and nucleic acid synthesis in vitro.
The effects of various dilutions of pineal extract upon leucine and thymidine incorporation by pituitary cells were studied in vitro, using a miniature cell culture system. A pineal extract dose-dependent increase in thymidine and leucine incorporation by these pituitary cells was observed. These effects may be related to either increased synthesis and/or decreased secretion of newly synthesized proteins.
Peress
N S
NS
Veterans Administration Hospital, Northport, N.Y. U.S.A.; Department of Pathology, State University of New York, Stony Brook, N.Y. U.S.A.
Murthy
G G
GG
Balcom
R J
RJ