Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein.
Although pharmacogenetics has been instrumental in describing interindividual variations in drug metabolism, epigenetic factors offer another blanket of information that could give a more vivid picture and help in developing a more personalized therapy. The dynamic aspect of epigenetics could likewise provide more definite answers to the role of changing environmental factors in drug response: the bridge that connects the environment to the genome. In this review we discuss known epigenetic and microRNA-dependent regulation of the human drug-metabolizing cytochromes P450 to help explain the unknown factors of variable drug response.
Gomez
Alvin
A
Section of Pharmacogenetics, Department of Physiology & Pharmacology, Karolinska Institutet, Sweden.
Ingelman-Sundberg
Magnus
M
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000235:genetics*; D004247:DNA / Q000096:biosynthesis / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D014176:Protein Biosynthesis / Q000235:genetics*
D035683:MicroRNAs; D004247:DNA; D003577:Cytochrome P-450 Enzyme System