Improvement in cell proliferation on silicone rubber by carbon nanotube coating.
Silicone rubbers are widely used as tissue implants because of their flexibility and chemical stability. However, they have limited cellular adhesiveness and may cause problems in the long term. In this study, a coating of carbon nanotubes (CNTs) was applied to silicone rubber to improve its cellular adhesiveness. Scanning electron micrograph of this coating revealed that CNTs had formed a densely packed meshwork; the Ra values and protein adsorption capacity were enhanced. Although the contact angle did not change after coating, it decreased after immersion into a culture medium. After cultivation for 6 d, while Saos-2 cells were hardly observed on untreated silicone, the cells proliferated on CNT-coated silicone. Thus, CNT coating might be a simple and effective solution to problems associated with silicone implants.
Matsuoka
Makoto
M
Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan. matsuoka@den.hokudai.ac.jp
Akasaka
Tsukasa
T
Hashimoto
Takeshi
T
Totsuka
Yasunori
Y
Watari
Fumio
F
D000042:Absorption; D002448:Cell Adhesion; D018929:Cell Culture Techniques / Q000379:methods; D002460:Cell Line; D002465:Cell Movement; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D005109:Extracellular Matrix / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D036103:Nanotechnology / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D010316:Particle Size; D016062:Porosity; D012826:Silicone Elastomers / Q000737:chemistry*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
D020099:Coated Materials, Biocompatible; D037742:Nanotubes, Carbon; D012826:Silicone Elastomers