Premenarchal ovarian torsion and elevated CA-125.
BACKGROUND
Ovarian tumors are the most common gynecologic malignancy occurring in childhood, with germ cell tumors being most frequent. This contrasts with adults where epithelial tumors account for most ovarian neoplasms. Tumor markers are an integral part of the work-up and may guide management.


METHODS
A 6-year-old girl with a persistent adnexal mass was found to have a highly elevated CA-125. Other tumor markers were normal. Laparoscopy revealed an enlarged, adherent ovary. A minilaparotomy revealed an ovary filled with necrotic material. This necrotic material was excised and the ovary was spared. The pathology was consistent with necrosis. Follow-up ultrasonography and CA-125 were normal.


CONCLUSIONS
This case demonstrates for the first time the association of an elevated CA-125 and ovarian torsion in a pediatric patient. This benign finding allowed attempting a conservative ovary-sparing approach during the surgery even in the presence of a highly elevated CA-125. However, in general, for children CA-125 is of limited utility, as it will not affect the indication for surgical exploration of persistent masses and elevations in CA-125 may discourage ovarian conservation.
McCarthy
Jenifer D
JD
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA. jmccarth@umich.edu
Erickson
Kimberly M
KM
Smith
Yolanda R
YR
Quint
Elisabeth H
EH
D018394:CA-125 Antigen / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D010535:Laparoscopy; D009336:Necrosis / Q000097:blood / Q000473:pathology / Q000601:surgery; D010049:Ovarian Diseases / Q000097:blood* / Q000473:pathology / Q000601:surgery; D014102:Torsion Abnormality / Q000097:blood* / Q000601:surgery
D018394:CA-125 Antigen