title: Bivalirudin as an anticoagulant for simultaneous integrated coronary artery revascularization - a novel approach to an inherent concern.
abstract: BACKGROUND
  Simultaneous integrated coronary artery revascularization combines coronary artery bypass surgery and percutaneous coronary intervention into a single procedure. This approach provides immediate, complete and optimal myocardial revascularization in a less invasive manner. Because simultaneous integrated coronary revascularization necessitates two distinct anticoagulation protocols for the surgical and percutaneous aspects of the procedure, combining these anticoagulation protocols carries a bleeding risk. Using a single anticoagulant to facilitate the necessities of both aspects of the integrated approach may alleviate this risk.
  
  
  METHODS
  A 45-year-old man with an occluded left anterior descending artery and a moderately stenotic circumflex artery underwent simultaneous integrated coronary revascularization. Bivalirudin was used to achieve anticoagulation for the duration of the procedure. The patient was asymptomatic with excellent patency of both the bypass graft and the stented circumflex artery via angiography at 10 months.
  
  
  CONCLUSIONS
  Bivalirudin can be used to effectively achieve a unified anticoagulation protocol for simultaneous integrated revascularization.
authors: Department of Surgery, Division of Cardiac Surgery, The University of Western Ontario, London Health Sciences Centre, University Hospital, London, Ontario N6A 5A5. scott.mcclure@lhsc.on.ca
authors: R Scott
authors: RS
authors: McClure
authors: Jennifer
authors: J
authors: Higgins
authors: Stuart A
authors: SA
authors: Swinamer
authors: Reiza
authors: R
authors: Rayman
authors: Wojciech B
authors: WB
authors: Dobkowski
authors: William J
authors: WJ
authors: Kostuk
authors: Bob
authors: B
authors: Kiaii
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000188:drug therapy*; D003331:Coronary Vessels; D006629:Hirudins; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D010446:Peptide Fragments / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; C074619:bivalirudin