title: Relation of multiple inflammatory biomarkers to incident atrial fibrillation.
abstract: Basic and clinical studies have suggested that inflammation predisposes to atrial fibrillation (AF). We assessed the association of 12 circulating inflammatory biomarkers (i.e., C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, osteoprotegerin, P-selectin, and tumor necrosis factor receptor II) with incident AF in 2863 Framingham Offspring Study participants (mean age 60.7 years, SD = 9.4, 55% women). During follow-up (median 6 years), 148 participants (43% women) developed incident AF. In the multivariable proportional hazards models, the inflammatory biomarker panel was associated with incident AF (p = 0.03). With stepwise selection (p <0.01 for entry and retention), log-transformed osteoprotegerin was associated with incident AF (hazard ratio per SD 1.30, 95% confidence interval 1.08 to 1.56, p = 0.006). Adjusting for interim myocardial infarction or heart failure attenuated the association between osteoprotegerin and incident AF (hazard ratio 1.18, 95% confidence interval 0.98 to 1.43, p = 0.09). In conclusion, circulating osteoprotegerin concentration was significantly associated with incident AF in our community-based sample, possibly mediated by interim cardiovascular events.
authors: National Heart Lung Blood Institute Framingham Study, Framingham, MA, USA.
authors: Renate B
authors: RB
authors: Schnabel
authors: Martin G
authors: MG
authors: Larson
authors: Jennifer F
authors: JF
authors: Yamamoto
authors: Sekar
authors: S
authors: Kathiresan
authors: Jian
authors: J
authors: Rong
authors: Daniel
authors: D
authors: Levy
authors: John F
authors: JF
authors: Keaney
authors: Thomas J
authors: TJ
authors: Wang
authors: Ramachandran S
authors: RS
authors: Vasan
authors: Emelia J
authors: EJ
authors: Benjamin
mesh_terms: D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D015415:Biomarkers; D002097:C-Reactive Protein; D016001:Confidence Intervals; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D053244:Osteoprotegerin / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D053244:Osteoprotegerin; D002097:C-Reactive Protein