Macrophage activation syndrome in malaria.
Macrophage activation syndrome (MAS) is a clinical syndrome caused by an excessive proliferation of T lymphocytes and well-differentiated macrophages; an entity distinct from malignant histiocytosis. Although rheumatologic conditions are the common cause of MAS, a wide range of infections are also seen to cause MAS. We report an adolescent with severe Plasmodium falciparum malaria and MAS. He fulfilled six out of eight criteria required to diagnose hemophagocytic lymphohistiocytosis.
Dass
Rashna
R
Department of Paediatric Disciplines, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Room no. 218, Mawdiangdiang, Shillong 793018, India. rashnadass@rediffmail.com
Barman
Himesh
H
Duwarah
Sourabh Gohain
SG
Choudhury
Vivek
V
Jain
Pankaj
P
Deka
Nayan Mani
NM
Murari
Manjula
M
D000293:Adolescent; D003937:Diagnosis, Differential; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis; D055501:Macrophage Activation Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008288:Malaria / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D008297:Male; D012720:Severity of Illness Index