A slice of pi : an exploratory neuroimaging study of digit encoding and retrieval in a superior memorist.
Subject PI demonstrated superior memory using a variant of a Method of Loci (MOL) technique to recite the first digits of the mathematical constant pi to more than 2(16) decimal places. We report preliminary behavioral, functional magnetic resonance imaging (fMRI), and brain volumetric data from PI. fMRI data collected while PI recited the first 540 digits of pi (i.e., during retrieval) revealed increased activity in medial frontal gyrus and dorsolateral prefrontal cortex. Encoding of a novel string of 100 random digits activated motor association areas, midline frontal regions, and visual association areas. Volumetric analyses indicated an increased volume of the right subgenual cingulate, a brain region implicated in emotion, mentalizing, and autonomic arousal. Wechsler Abbreviated Scale of Intelligence (WASI) testing indicated that PI is of average intelligence, and performance on mirror tracing, rotor pursuit, and the Silverman and Eals Location Memory Task revealed normal procedural and implicit memory. PI's performance on the Wechsler Memory Scale (WMS-III) revealed average general memory abilities (50th percentile), but superior working memory abilities (99th percentile). Surprisingly, PI's visual memory (WMS-III) for neutral faces and common events was remarkably poor (3rd percentile). PI's self-report indicates that imagining affective situations and high emotional content is critical for successful recall. We speculate that PI's reduced memory for neutral/non-emotional faces and common events, and the observed increase in volume of the right subgenual cingulate, may be related to extensive practice with memorizing highly emotional material.
Raz
Amir
A
MRI Unit in the Department of Psychiatry, Columbia University College of Physicians & Surgeons and the New York State Psychiatric Institute, New York, NY, USA.
Packard
Mark G
MG
Alexander
Gerianne M
GM
Buhle
Jason T
JT
Zhu
Hongtu
H
Yu
Shan
S
Peterson
Bradley S
BS
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping; D005145:Face; D005260:Female; D005385:Fingers; D006801:Humans; D007360:Intelligence; D007361:Intelligence Tests; D007858:Learning / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D009483:Neuropsychological Tests; D009929:Organ Size; D010775:Photic Stimulation; D014796:Visual Perception; D055815:Young Adult