Ultrasound-assisted one-pot, three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones.
Triethylamine was found to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in ethanol under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of ethanol as a solvent that is considered to be relatively environmentally benign.
Nabid
Mohammad Reza
MR
Department of Chemistry, Shahid Beheshti University, G.C., P.O. Box 19396-4716, Tehran, Iran.
Rezaei
Seyed Jamal Tabatabaei
SJ
Ghahremanzadeh
Ramin
R
Bazgir
Ayoob
A
D002384:Catalysis; D000431:Ethanol / Q000737:chemistry* / Q000528:radiation effects; D005021:Ethylamines / Q000737:chemistry* / Q000528:radiation effects*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000528:radiation effects*; D011829:Radiation Dosage; D013010:Sonication / Q000379:methods*
D005021:Ethylamines; D011724:Pyridazines; C100108:diftalone; D000431:Ethanol; C016162:triethylamine