Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica.
Eight new prenylated flavonoids, ugonins M-T (1-8), together with five known compounds, ugonins J-L (9-11), 5,4'-dihydroxy-4'',4''-dimethyl-5''-methyl-5''H-dihydrofurano[2'',3'':6,7]flavanone, and quercetin, were isolated and purified from the rhizomes of Helminthostachys zeylanica. The structures of the new isolates were elucidated by spectroscopic and chemical methods. Compounds 1, 3, 5, 7, 8, and 11 showed inhibition of superoxide anion generation and elastase release by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (FMLP/CB).
Huang
Yaun-Chao
YC
Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung 404, Taiwan, Republic of China.
Hwang
Tsong-Long
TL
Chang
Chih-Shiang
CS
Yang
Yu-Liang
YL
Shen
Chia-Ning
CN
Liao
Wen-Ying
WY
Chen
Sheng-Chih
SC
Liaw
Chih-Chuang
CC
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003571:Cytochalasin B / Q000494:pharmacology; D029624:Ferns / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects*; D027343:Rhizome / Q000737:chemistry; D013624:Taiwan
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D003571:Cytochalasin B; D009240:N-Formylmethionine Leucyl-Phenylalanine