Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer.
Using exciton-coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host-guest complex formed with (+)-(S)-methamphetamine produced a negative bisignate-shaped ECCD spectrum, whereas the complex formed with (-)-(R)-methamphetamine produced a positive one. This sensitive technique could serve as an alternative method for the enantiodiscrimination of chiral methamphetamine, a commonly abused drug in the United States.
Anderson
Marcus
M
Department of Chemistry, Doane College, Crete, Nebraska 68333, USA.
Wilcox
Katie
K
Guericke
Mike
M
Chu
Han
H
Wilson
Mark V
MV
Wilson
Erin
E
Lucas
Kerry
K
Holmes
Andrea E
AE
D002623:Chemistry Techniques, Analytical / Q000379:methods; D002942:Circular Dichroism / Q000379:methods*; D004337:Drug Carriers; D009682:Magnetic Resonance Spectroscopy; D008694:Methamphetamine / Q000032:analysis* / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry*; D012044:Regression Analysis; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013237:Stereoisomerism; D013696:Temperature; D014466:Ultraviolet Rays
D004337:Drug Carriers; D011166:Porphyrins; D008694:Methamphetamine