A nonself RNA pattern: tri-p to panhandle.
In this issue of Immunity, Schlee et al. (2009) defines key RNA structures recognized by a cellular viral sensor, RIG-I. This and another recent report by Schmidt et al. (2009) provide new insights into the mechanism of antiviral innate immunity.
Fujita
Takashi
T
Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan. tfujita@virus.kyoto-u.ac.jp
D000818:Animals; D053487:DEAD-box RNA Helicases / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000276:immunology* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000276:immunology* / Q000378:metabolism; D009690:Nucleic Acid Conformation; D012328:RNA Viruses / Q000276:immunology* / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000276:immunology / Q000378:metabolism; D012367:RNA, Viral / Q000276:immunology* / Q000378:metabolism; D011956:Receptors, Cell Surface; D018168:Receptors, Retinoic Acid / Q000276:immunology* / Q000378:metabolism; D014779:Virus Replication / Q000276:immunology; D000097905:Roundabout Proteins
D053487:DEAD-box RNA Helicases; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D012330:RNA, Double-Stranded; D012367:RNA, Viral; D011956:Receptors, Cell Surface; D018168:Receptors, Retinoic Acid; C437968:PLAAT4 protein, human; C118348:Robo3 protein, mouse; D000097905:Roundabout Proteins