title: Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults.
abstract: A total of 600 healthy adults > or =65 years were randomized to receive 2 vaccinations 1 month apart of a subvirion avian influenza A/H5N1 vaccine containing 3.75, 7.5, 15, or 45microg of hemagglutinin (HA) with or without aluminum hydroxide (AlOH). All formulations were safe. Groups given the vaccine with AlOH had more injection site discomfort. Dose-related increases in antibody responses were noted after the second vaccination. Antibody responses to the vaccine were not enhanced by AlOH at any HA dose level. A microneutralization titer > or =40 was observed in 36% and 40% of subjects who received 45microg of HA with or without AlOH, respectively.
authors: Cincinnati Children's Hospital Medical Center, OH 45229-3039, United States. rebecca.brady@cchmc.org
authors: Rebecca C
authors: RC
authors: Brady
authors: John J
authors: JJ
authors: Treanor
authors: Robert L
authors: RL
authors: Atmar
authors: Wendy A
authors: WA
authors: Keitel
authors: Robert
authors: R
authors: Edelman
authors: Wilbur H
authors: WH
authors: Chen
authors: Patricia
authors: P
authors: Winokur
authors: Robert
authors: R
authors: Belshe
authors: Irene L
authors: IL
authors: Graham
authors: Diana Lee
authors: DL
authors: Noah
authors: Kuo
authors: K
authors: Guo
authors: Heather
authors: H
authors: Hill
mesh_terms: D000276:Adjuvants, Immunologic; D000368:Aged; D000536:Aluminum Hydroxide / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D009500:Neutralization Tests; D014611:Vaccination
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines; D000536:Aluminum Hydroxide