Kinetics of pertussis immune responses to tetanus-diphtheria-acellular pertussis vaccine in health care personnel: implications for outbreak control.
We assessed the kinetics of the humoral immune response to pertussis antigens following vaccination of health care personnel with adult tetanus-diphtheria-acellular pertussis vaccine (Tdap). By 2 weeks after vaccination, 88%-94% of subjects demonstrated a booster response. This brisk response of adults to Tdap supports a role for vaccination in pertussis outbreak control.
Kirkland
Kathryn B
KB
Department of Medicine, Section of Infectious Disease and International Health, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA. kathy.kirkland@hitchcock.org
Talbot
Elizabeth A
EA
Decker
Michael D
MD
Edwards
Kathryn M
KM
D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000276:immunology*; D004196:Disease Outbreaks / Q000517:prevention & control*; D005260:Female; D006282:Health Personnel; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control*; D055815:Young Adult
D000907:Antibodies, Bacterial; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines