Prevalence of viral hepatitis and molecular analysis of HBV among voluntary blood donors in west Iran.
To determine the prevalence of viral hepatitis infection and hepatitis B virus (HBV) molecular characterization, 11,200 blood donors from citizens of Shahrekord (a city located in west of Iran) were investigated. Results showed HBsAg-positive in 1.78% of persons (n=200), anti-HDV-positive in 3% of HBsAg-positive cases (n=6) and anti-HCV-positive in 0.67% of donors (n=76). HBV phylogenetic analysis disclosed HBV genotype D, sub-genotype D1, and subtype ayw2. Amino acid mapping of the HBV pol region revealed various HBV drug-resistance mutations though donors had no antiviral therapy. In conclusion, this study demonstrated notable viral hepatitis seroprevalence rate in blood donors in west of Iran.
Doosti
Abbas
A
Biotechnology Research Centre, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran.
Amini-Bavil-Olyaee
Samad
S
Tajbakhsh
Elaheh
E
Adeli
Ahmad
A
Mahboudi
Fereidoun
F
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D004279:DNA, Viral / Q000032:analysis; D024882:Drug Resistance, Viral / Q000235:genetics; D005260:Female; D015751:Genes, pol / Q000235:genetics; D016174:Hepacivirus / Q000302:isolation & purification; D006515:Hepatitis B virus / Q000235:genetics* / Q000302:isolation & purification; D003698:Hepatitis Delta Virus / Q000302:isolation & purification; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D016036:Seroepidemiologic Studies
D004279:DNA, Viral