title: A new bifunctional chelator for copper radiopharmaceuticals: a cage amine ligand with a carboxylate functional group for conjugation to peptides.
abstract: A new sarcophagine cage amine ligand with a pendent carboxylate functional group has been synthesised; the ligand has been conjugated to tumour targeting peptides ([Tyr3]-octreotate and [Lys3]-bombesin) and the conjugates radiolabelled with copper-64.
authors: School of Chemistry, University of Melbourne, Parkville, Melbourne, Victoria, 3010, Australia.
authors: Michelle T
authors: MT
authors: Ma
authors: John A
authors: JA
authors: Karas
authors: Jonathan M
authors: JM
authors: White
authors: Denis
authors: D
authors: Scanlon
authors: Paul S
authors: PS
authors: Donnelly
mesh_terms: D000588:Amines / Q000737:chemistry*; D000818:Animals; D002264:Carboxylic Acids / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D010455:Peptides / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry*
chemical_list: D000588:Amines; D002264:Carboxylic Acids; D002614:Chelating Agents; D003432:Cross-Linking Reagents; D008024:Ligands; D010455:Peptides; D019275:Radiopharmaceuticals; D003300:Copper