Disorder, promiscuity, and toxic partnerships.
Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. Vavouri et al. (2009) find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive oncogenes in mice and humans.
Marcotte
Edward M
EM
Department of Chemistry and Biochemistry, University of Texas at Austin, 2500 Speedway, Austin, TX 78712-1064, USA. marcotte@icmb.utexas.edu
Tsechansky
Mark
M
D000818:Animals; D015870:Gene Expression; D006801:Humans; D011506:Proteins / Q000378:metabolism* / Q000633:toxicity*
D011506:Proteins