Is there variation in crossover interference levels among chromosomes from human males?
We demonstrate that recent data from human males are consistent with constant interference levels among chromosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distributions to immunofluorescent interfoci distances observed on finite chromosomes generates false interpretations of higher levels of interference on shorter chromosomes. We provide appropriate statistical methodology.
Housworth
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EA
Mathematics, Biology, and Statistics Departments, Indiana University, Bloomington, Indiana 47405, USA. ehouswor@indiana.edu
Stahl
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FW
D002874:Chromosome Mapping / Q000706:statistics & numerical data; D002877:Chromosomes, Human / Q000235:genetics*; D003434:Crossing Over, Genetic / Q000235:genetics*; D014644:Genetic Variation / Q000502:physiology*; D015894:Genome, Human; D006801:Humans; D008297:Male; D008540:Meiosis / Q000235:genetics; D012737:Sex Factors; D016008:Statistical Distributions