title: Controlled clinical, polysomnographic and psychometric studies on differences between sleep bruxers and controls and acute effects of clonazepam as compared with placebo.
abstract: The pathogenesis, pathophysiology, and pharmacotherapy of sleep bruxism (SB) are still not fully understood. We investigated symptomatology, objective and subjective sleep and awakening quality of middle-aged bruxers compared with controls and acute effects of clonazepam 1 mg compared with placebo by polysomnography and psychometry. Twenty-one drug-free bruxers spent 3 nights in the sleep lab, 21 age- and sex-matched controls 2 nights. Clinically, bruxers exhibited deteriorated PSQI, SAS, SDS and IRLSSG measures, polysomnographically impaired sleep maintenance, increased movement time, stage shift index, periodic leg movements (PLM) and arousals and psychometrically deteriorated subjective sleep and awakening quality, evening/morning well-being, drive, mood, drowsiness, attention variability, memory, and fine motor activity. As compared with placebo, clonazepam significantly decreased the SB index in all patients (mean: -42 +/- 15%). Sleep efficiency, maintenance, latency, awakenings and nocturnal wake time, the stage shift index, S1, PLM, the arousal index, subjective sleep and awakening quality, and fine motor activity improved.
authors: Department of Periodontology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, Austria.
authors: Alexander
authors: A
authors: Saletu
authors: Silvia
authors: S
authors: Parapatics
authors: Peter
authors: P
authors: Anderer
authors: Michael
authors: M
authors: Matejka
authors: Bernd
authors: B
authors: Saletu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002998:Clonazepam / Q000494:pharmacology / Q000627:therapeutic use*; D018592:Cross-Over Studies; D005260:Female; D018757:GABA Modulators / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017286:Polysomnography / Q000379:methods*; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics / Q000379:methods*; D011597:Psychomotor Performance / Q000187:drug effects; D016037:Single-Blind Method; D020186:Sleep Bruxism / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D018709:Statistics, Nonparametric; D014851:Wakefulness / Q000187:drug effects
chemical_list: D018757:GABA Modulators; D002998:Clonazepam