Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma.
Due to the highly glycolytic metabolism of solid tumours, there is an increased acid production, however, cells are able to maintain physiological pH through plasma membrane efflux of the accumulating protons. Acid efflux through MCTs (monocarboxylate transporters) constitutes one of the most important mechanisms involved in tumour intracellular pH maintenance. Still, the molecular mechanisms underlying the regulation of these proteins are not fully understood. We aimed to evaluate the association between CD147 (MCT1 and MCT4 chaperone) and MCT expression in cervical cancer lesions and the clinico-pathological significance of CD147 expression, alone and in combination with MCTs. The series included 83 biopsy samples of precursor lesions and surgical specimens of 126 invasive carcinomas. Analysis of CD147 expression was performed by immunohistochemistry. CD147 expression was higher in squamous and adenocarcinoma tissues than in the non-neoplastic counterparts and, importantly, both MCT1 and MCT4 were more frequently expressed in CD147 positive cases. Additionally, co-expression of CD147 with MCT1 was associated with lymph-node and/or distant metastases in adenocarcinomas. Our results show a close association between CD147 and MCT1 and MCT4 expressions in human cervical cancer and provided evidence for a prognostic value of CD147 and MCT1 co-expression.
Pinheiro
Céline
C
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, Braga, Portugal.
Longatto-Filho
Adhemar
A
Pereira
Sônia Maria Miranda
SM
Etlinger
Daniela
D
Moreira
Marise A R
MA
Jubé
Luiz Fernando
LF
Queiroz
Geraldo Silva
GS
Schmitt
Fernando
F
Baltazar
Fátima
F
D051926:Basigin / Q000378:metabolism*; D005260:Female; D006801:Humans; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism*; D027981:Symporters / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*; D000099233:Monocarboxylate Transport Protein 1
D051926:Basigin; D027501:Monocarboxylic Acid Transporters; D009124:Muscle Proteins; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1; C406962:SLC16A4 protein, human