Lithium-induced membranous glomerulonephropathy in a pediatric patient.
Lithium-induced glomerular toxicity is an infrequent occurrence in pediatric patients. We report a 13-year-old patient presenting with clinical and laboratory evidence of renal insufficiency after long-term lithium use. Biopsy revealed membranous glomerulonephropathy. Discontinuation of the lithium treatment resulted in resolution of the symptoms and laboratory abnormalities. Other alkali metals have been implicated as risk factors for membranous glomerulonephropathy. To the best of our knowledge, this is the first reported case of lithium-induced glomerulonephropathy in a pediatric patient.
Kala
Gunjeet K
GK
Women and Children's Hospital of Buffalo, New York 14222, USA. gkala1@hotmail.com
Mogri
Muniza
M
Weber-Shrikant
Edit
E
Springate
James E
JE
D000293:Adolescent; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D004656:Enalapril / Q000627:therapeutic use; D005500:Follow-Up Studies; D015433:Glomerulonephritis, Membranous / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000601:surgery / Q000648:ultrastructure; D007678:Kidney Glomerulus / Q000473:pathology; D008094:Lithium / Q000633:toxicity*; D008297:Male; D012709:Serum Albumin / Q000032:analysis; D013997:Time Factors; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D012709:Serum Albumin; D004656:Enalapril; D008094:Lithium; D003404:Creatinine