Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases.
Autophagy is a conserved homeostatic process by which cells degrade and recycle cytoplasmic contents and organelles. Recently, autophagy has come to prominence as a factor in many disease states, including inflammatory bowel diseases. In this review we explore the recent discoveries in autophagy and how these relate to the special conditions experienced by the gut mucosa. We will pay particular attention to autophagy as an innate immune process and its role in the development and education of the adaptive immune system.
Huett
Alan
A
Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. ahuett@ccib.mgh.harvard.edu
Xavier
Ramnik J
RJ
D000818:Animals; D001343:Autophagy / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000473:pathology*; D007413:Intestinal Mucosa / Q000276:immunology*