Glycolipid ester-type heterodimers from Ipomoea tyrianthina and their pharmacological activity.
Tyrianthins A (1) and B (2), two new partially acylated glycolipid ester-type heterodimers were isolated from Ipomoea tyrianthina. Scammonic acid A was determined as the glycosidic acid in both monomeric units. Tyrianthin A (1) (IC(50) 0.24+/-0.09 microM and E(max) 81.80+/-0.98%), and tyrianthin B (2) (IC(50) 0.14+/-0.08 microM and E(max) 87.68+/-0.72%) showed significant in vitro relaxant effect on aortic rat rings, in endothelium- and concentration-dependent manners. Also, these compounds were able to increase the release of GABA and glutamic acid in brain cortex, and displayed weak antimycobacterial activity.
León-Rivera
Ismael
I
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico.
Mirón-López
Gumersindo
G
Estrada-Soto
Samuel
S
Aguirre-Crespo
Francisco
F
Gutiérrez
María del Carmen
Mdel C
Molina-Salinas
Gloria María
GM
Hurtado
Gerardo
G
Navarrete-Vázquez
Gabriel
G
Montiel
Elizur
E
D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019281:Dimerization; D018698:Glutamic Acid / Q000378:metabolism; D006017:Glycolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D027741:Ipomoea / Q000737:chemistry*; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D014665:Vasodilator Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000995:Antitubercular Agents; D006017:Glycolipids; D014665:Vasodilator Agents; C543951:tyrianthin A; C543950:tyrianthin B; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid