Ischemic tolerance in the cochlea.
Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single ischemia group and double ischemia group. In the single ischemia group, animals were subjected to lethal cochlear ischemia for 15 min. In the double ischemia group, animals were subjected to sublethal cochlear ischemia for 2 min at 2 days before lethal ischemia for 15 min. Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea.
Takeda
Shoichiro
S
Department of Otolaryngology, Ehime University Graduate School of Medicine, Shitsukawa, Ehime, Japan.
Hata
Ryuji
R
Cao
Fang
F
Yoshida
Tadashi
T
Hakuba
Nobuhiro
N
Hato
Naohito
N
Gyo
Kiyofumi
K
D000818:Animals; D003051:Cochlea / Q000098:blood supply*; D005849:Gerbillinae; D006199:Hair Cells, Auditory, Inner / Q000473:pathology; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000517:prevention & control; D007511:Ischemia / Q000150:complications / Q000473:pathology* / Q000517:prevention & control; D019194:Ischemic Preconditioning; D008297:Male