title: Danazol for uterine fibroids.
abstract: BACKGROUND
  Uterine fibroids (myomas, fibromyomas, leiomyomas) are the most common benign tumours of the female genital tract. Danazol, a synthetic isoxazole derivative chemically related to 17-ethinyl testosterone, has been used for many years for the treatment of women with uterine fibroids.
  
  
  OBJECTIVE
  To evaluate the effectiveness and safety of danazol in women with uterine fibroids.
  
  
  METHODS
  We searched the Cochrane Menstrual Disorders and Subfertility Review Group Specialised Register; Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, Issue 4); MEDLINE; EMBASE; Chinese Biomedical Disc; and the China National Knowledge Infrastructure for relevant trials (to December 2008). Attempts were made to identify trials from references in published studies. We also searched for ongoing trials in the five major clinical trials registries.
  
  
  METHODS
  Randomised controlled trials of danazol versus placebo or any other medical therapy in women with uterine fibroids confirmed by medical procedures, regardless of the women's symptoms or age. Women with malignancies were excluded.
  
  
  METHODS
  Data extraction and risk of bias assessment were not been performed because there were no identified studies.
  
  
  RESULTS
  We did not identify any studies which met our full inclusion criteria.
  
  
  CONCLUSIONS
  There is no reliable evidence available from randomised controlled trials regarding the benefits and or harms of the use of danazol for treating uterine fibroids.
authors: West China Medical School of Sichuan University, South of Renmin Road 17#, Chengdu, China.
authors: Lin-Qiu
authors: LQ
authors: Ke
authors: Kun
authors: K
authors: Yang
authors: Jing
authors: J
authors: Li
authors: Chun-Mei
authors: CM
authors: Li
mesh_terms: D003613:Danazol / Q000627:therapeutic use*; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*
chemical_list: D004965:Estrogen Antagonists; D003613:Danazol