title: Anidulafungin in combination with amphotericin B against Aspergillus fumigatus.
abstract: We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.
authors: Dipartimento di Scienze Biomediche, Clinica di Malattie Infettive, Università Politecnica delle Marche, Ancona, Italy.
authors: Elisabetta
authors: E
authors: Spreghini
authors: Fiorenza
authors: F
authors: Orlando
authors: Alfredo
authors: A
authors: Santinelli
authors: Eleonora
authors: E
authors: Pisa
authors: Cristian
authors: C
authors: Loretelli
authors: Esther
authors: E
authors: Manso
authors: Maria Eleonara
authors: ME
authors: Milici
authors: Giorgio
authors: G
authors: Scalise
authors: Francesco
authors: F
authors: Barchiesi
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy / Q000401:mortality; D001232:Aspergillus fumigatus / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000666:Amphotericin B; D000077612:Anidulafungin