Helical chiral pyridine N-oxides: a new family of asymmetric catalysts.
Optically active chiral alkyl chlorides are valuable compounds because of their bioactivity and versatile synthetic utility. Accordingly, the ring opening of epoxides with a chloride nucleophile stands as an important goal in asymmetric catalysis. We describe herein recent advances in the design and development of chiral pyridine N-oxide catalysts for the enantioselective synthesis of chlorohydrins.
Chen
Jinshui
J
Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146-0431, USA.
Takenaka
Norito
N
D002384:Catalysis; D002728:Chlorohydrins / Q000138:chemical synthesis*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D002728:Chlorohydrins; D011725:Pyridines; C013229:pyridine N-oxide