[In vivo delivery of siRNA].
RNA interference (RNAi) is a mechanism of posttranscriptional gene silencing mediated by small interfering RNA (siRNA). The ability of synthetic siRNA to silence genes in vivo has made it well suited as therapeutic drug, but the instability and polarity of siRNA and the complexity of in vivo circumstances retarded rapid development of RNAi-based therapies. In this review, a summary of the advances on in vivo siRNA delivery is presented and discussed.
Shi
Ming-Lei
ML
Beijing Institute of Biotechnology, Beijing 100071, China. shiml1@yahoo.com.cn
Zhao
Zhi-Hu
ZH
Wang
Yang
Y
Chen
Hui-Peng
HP
D000818:Animals; D000906:Antibodies / Q000378:metabolism; D005822:Genetic Vectors / Q000378:metabolism; D006801:Humans; D053758:Nanoparticles; D010455:Peptides / Q000378:metabolism; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000378:metabolism*
D000906:Antibodies; D010455:Peptides; D034741:RNA, Small Interfering