title: Global left ventricular function: assessment with dual-source CT versus conventional ventriculography in a porcine model.
abstract: OBJECTIVE
  Cardiac computed tomography (CT) and conventional biplane ventriculography are established methods for the determination of ventricular function. Recently dual source CT was introduced for cardiac CT scanning providing a temporal resolution of 83 ms independent of the patient's heart rate. The purpose of this study was to assess the global left ventricular function using retrospectively ECG-gated dual source computed tomography (DSCT) in comparison to conventional ventriculography.
  
  
  RESULTS
  Contrast-enhanced cardiac DSCT and conventional ventriculography were performed in 10 domestic pigs with an approximate weight of 60 kg using standardized examination protocols under general anaesthesia. From manually drawn endocardial contours, LV end-systolic (ESV) and end-diastolic volume (EDV), stroke volume (SV), ejection fraction (EF) were calculated by means of dedicated analysis software separately for both examination modalities. LV functional parameters were analysed using Bland-Altman plots, Student t-test, and Pearson correlation coefficient. Left ESV and EDV determined with DSCT correlated well with conventional ventriculography results (ESV: r = 0.86; EDV: r = 0.72) with a good correlation also for SV (r = 0.67).An only moderate correlation was found for EF (r = 0.52). Student t-test showed a significant underestimation of SV and EF derived from DSCT in comparison to ventriculography.
  
  
  CONCLUSIONS
  Retrospectively ECG-gated DSCT can accurately determine LV volumes in comparison to conventional ventriculography but provides lower SV and EF values; however, the correlation was only moderate.
authors: Applied Medical Engineering, Helmholtz-Institute for Biomedical Engineering, Aachen, Germany. bruners@hia.rwth-aachen.de
authors: Philipp
authors: P
authors: Bruners
authors: Christian
authors: C
authors: Knackstedt
authors: Andreas H
authors: AH
authors: Mahnken
authors: Nadja
authors: N
authors: Luhmann
authors: Marco
authors: M
authors: Das
authors: Christian
authors: C
authors: Fach
authors: Thomas
authors: T
authors: Schmitz-Rode
authors: Rolf W
authors: RW
authors: Günther
authors: Malte
authors: M
authors: Kelm
authors: Georg
authors: G
authors: Mühlenbruch
mesh_terms: D000818:Animals; D002302:Cardiac Output; D003971:Diastole; D004195:Disease Models, Animal; D006352:Heart Ventricles / Q000002:abnormalities / Q000000981:diagnostic imaging*; D006801:Humans; D012189:Retrospective Studies; D013223:Statistics as Topic; D013318:Stroke Volume; D013552:Swine; D013599:Systole; D014057:Tomography, X-Ray Computed; D016277:Ventricular Function, Left / Q000502:physiology*