title: Two-year follow-up in 21,784 overweight children and adolescents with lifestyle intervention.
abstract: Although randomized controlled trials demonstrated the long-term efficacy of lifestyle interventions in overweight children, the effects of these interventions in clinical practice under real-life conditions are largely unknown. One hundred twenty-nine centers specialized in outpatient pediatric obesity care participated in this quality assessment. All patients presenting before the year 2006 for lifestyle intervention of at least 6 months duration in these institutions were analyzed in a 2-year follow-up. A total of 21,784 (45% male) overweight children and adolescents aged 2-20 years (mean BMI 30.4 kg/m2, mean SDS-BMI 2.51, mean age 12.6 years) were included in the analysis. Based on an intention-to-treat analysis with variables set back to baseline in lost of follow-up, 22% of the children reduced their SDS-BMI after 6 months, 15% after 12 months, and 7% after 24 months, but only in 24, 17, and 8% of children, respectively, complete data were available. In the five treatment centers with the best outcome (518 patients), 83% of the children reduced their overweight after 6 months, 67% after 12 months, and 51% after 24 months. Under real-life conditions, most treatment centers cannot prove the long-term efficacy of their interventions due to high drop-out rate or lack of documentation. Conversely, some institutions achieved a reduction of overweight in nearly the half of their patients 24 months after baseline demonstrating the great heterogeneity in outcome. To improve the effectiveness of lifestyle interventions in real-life studying, the process and structure quality as well as their long-term results is urgently needed.
authors: Department of Pediatric Nutrition Medicine, Vestische Children's Hospital, University of Witten/Herdecke, Witten, Germany. T.Reinehr@kinderklinik-datteln.de
authors: Thomas
authors: T
authors: Reinehr
authors: Kurt
authors: K
authors: Widhalm
authors: Dagmar
authors: D
authors: l'Allemand
authors: Susanna
authors: S
authors: Wiegand
authors: Martin
authors: M
authors: Wabitsch
authors: Reinhard W
authors: RW
authors: Holl
mesh_terms: D000293:Adolescent; D001317:Austria; D001521:Behavior Therapy; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005081:Exercise Therapy; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008499:Medical Records; D016017:Odds Ratio; D050177:Overweight / Q000178:diet therapy / Q000523:psychology / Q000628:therapy*; D010352:Patient Dropouts; D018570:Risk Assessment; D040242:Risk Reduction Behavior; D013557:Switzerland; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss; D055815:Young Adult