Genotypes and clinical data of respiratory syncytial virus and metapneumovirus in brazilian infants: a new perspective.
The aim of this study was to determine if there was a correlation between respiratory syncytial virus (RSV) and metapneumovirus (MPV) genotypes and clinical data of Brazilian infants hospitalized for acute lower respiratory infection. The viruses in the patients' nasopharyngeal secretions were studied using the polymerase chain reaction and phylogenetic analysis. The study assessed 144 infants; 31.9% were RSV positive and 5.6% were MPV positive. Statistical analysis was performed using the chi-squared test, Fisher's test, Odds ratio, univariate logistic regression, non-conditional multivariate logistic regression and the forward - stepwise method. Multivariate analysis confirmed a significant relationship between a positive PCR test for RSV and hospitalization during the month of May and with pulse oximetry less than 90%. The phylogenetic analysis indicated the genotypes GA2, GA5, SAA1 (Group A), SAB1, SAB3 and BA (Group B) for RSV and Group B, subgroup B1, for MPV.
Riccetto
Adriana Gut Lopes
AG
Pediatrics Department, State University of Campinas, Brazil. a.riccetto@uol.com.br
Silva
Luciana Helena Antoniassi da
LH
Spilki
Fernando Rosado
FR
Morcillo
André Moreno
AM
Arns
Clarice Weis
CW
Baracat
Emílio Carlos Elias
EC
D000208:Acute Disease; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D029121:Metapneumovirus / Q000235:genetics* / Q000302:isolation & purification; D015999:Multivariate Analysis; D018184:Paramyxoviridae Infections / Q000821:virology*; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D018357:Respiratory Syncytial Virus Infections / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000235:genetics* / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000821:virology*
D012367:RNA, Viral