title: The use of a Type-I lyophilisate collagen as an osteoinductive factor in pseudarthroses of the forearm.
abstract: The purpose of this study was to assess the use of a novel bone void filler consisting of Type I collagen and various growth factors (VEGF, TGFβ-1, TGFβ-2, IGF-1, BMP-2, BMP-3, and BMP-7) and surgical fixation to treat diaphyseal forearm pseudarthroses. Eleven patients underwent an osteosynthesis procedure for isolated pseudarthrosis fractures of the forearm (six radial and five ulnar diaphysis). The mean duration between the initial failed surgical fixation and re-operation was 38 weeks. Radiographic signs of fracture healing after the application of the bone void filler were noted at a mean of 5 weeks, and complete fracture consolidation was achieved at a mean of 6 weeks. All patients demonstrated improved range of motion and grip strength. Additionally, all patients were pain-free by 6 weeks. The combination of a novel bovine bone-derived bone void filler and stable internal fixation led to union and rapid healing of forearm pseudarthroses.
authors: Department of Orthopaedic Surgery, Klinikum Starnberg, Starnberg, Germany.
authors: M
authors: M
authors: Strassmair
authors: M A
authors: MA
authors: Mont
authors: T M
authors: TM
authors: Seyler
authors: H
authors: H
authors: Bosebeck
authors: D R
authors: DR
authors: Marker
authors: D M
authors: DM
authors: LaPorte
mesh_terms: D000328:Adult; D018786:Bone Substitutes / Q000627:therapeutic use*; D024042:Collagen Type I / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005542:Forearm / Q000601:surgery*; D005593:Fracture Fixation, Internal / Q000295:instrumentation / Q000379:methods*; D005612:Freeze Drying; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis; D011542:Pseudarthrosis / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018786:Bone Substitutes; D024042:Collagen Type I; D036341:Intercellular Signaling Peptides and Proteins