title: Role of L-MYC polymorphism in oral squamous cell carcinoma in Turkey.
abstract: BACKGROUND
  An association between restriction fragment length polymorphism (RFLP) of known oncogenes and a predisposition to develop cancer has been postulated. Our aim was to test the hypothesis that there was an association between the L-MYC S allele in oral squamous cell carcinoma (OSCC) and a predisposition for the disease.
  
  
  METHODS
  The distribution of L-MYC polymorphism in 80 patients with OSCC was determined by polymerase chain reaction-based RFLP and compared with that of 60 healthy controls.
  
  
  RESULTS
  There was no significant difference between patients with OSCC and healthy controls. Patients with the L-MYC S allele and a positive family history of cancer were found to be 1.74 times more at risk for OSCC than those with any other genotype (95% confidence interval=0.88-3.45). Moreover, tumor recurrence was higher among individuals carrying a L-MYC S allele than those with any other allele type.
  
  
  CONCLUSIONS
  L-MYC polymorphism was not a significant marker for predicting susceptibility to OSCC in this population but may be a useful marker for identifying patient susceptibility to tumor recurrence and to developing OSCC, especially in individuals having a family history of cancer.
authors: Department of Oral Surgery and Medicine, Faculty of Dentistry, Istanbul University, Capa/Istanbul, Turkey. bektask76@yahoo.com
authors: Kivanç
authors: K
authors: Bektas-Kayhan
authors: Meral
authors: M
authors: Unür
authors: Ilhan
authors: I
authors: Yaylim-Eraltan
authors: Arzu
authors: A
authors: Ergen
authors: Günter
authors: G
authors: Hafiz
authors: Ahmet
authors: A
authors: Karadeniz
authors: Turgay
authors: T
authors: Isbir
mesh_terms: D000328:Adult; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D017931:DNA Primers; D005260:Female; D016259:Genes, myc; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D014421:Turkey
chemical_list: D017931:DNA Primers