[Effects of simvastatin on the immune-related genes of mouse osteoblasts].
OBJECTIVE
To investigate the expression of immune-related genes during osteogenesis stimulated by simvastatin.


METHODS
After treated with simvastatin, the expression of immune-related genes of mouse osteoblast was examined with gene chip (BiostarM-140s).


RESULTS
There were 16 differently expressed genes related to immune function, with nine down-regulated genes and seven up-regulated genes.


CONCLUSIONS
After treated with simvastatin, expression of inflammation related genes is down-regulated and inflammation inhibitor genes is up-regulated in mouse osteoblasts.
Hu
Fei
F
Department of Orthodontics, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou 510280, China.
Zhang
Xue-yang
XY
Zhou
Lei
L
D000818:Animals; D015536:Down-Regulation; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects* / Q000276:immunology; D010012:Osteogenesis / Q000187:drug effects*; D019821:Simvastatin / Q000494:pharmacology*
D019821:Simvastatin