Plasma level of granulocyte-colony stimulating factor during granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis.
OBJECTIVE
Cytapheresis with extra-corporeal circulation for ulcerative colitis is effective but its mechanisms are still unclear. Granulocytecolony stimulating factor (G-CSF) strongly mobilizes bone marrow-derived cells and serves as antiinflammatory factor. We investigated plasma levels of G-CSF during granulocyte and monocyte adsorptive apheresis (GCAP).


METHODS
Nineteen cases of ulcerative colitis were measured plasma concentration of G-CSF during the first session of GCAP therapy.


RESULTS
G-CSF were significantly increased in the column inflow at 30 min compared with the baseline (Wilcoxon test, p < 0.01), and also increased through the column (Wilcoxon test, p < 0.01). The ratio of the increase in the column outflow at 60 min was 1.5-fold compared with the baseline. However, we could not show a significant relation between G-CSF level and clinical efficacy.


CONCLUSIONS
This is the first report concerning G-CSF during CAP. G-CSF is increased due to GCAP and appears to be a candidate which should be further investigated.
Takeda
Hiroaki
H
Division of Endoscopy, Yamagata University Hospital, Yamagata, Japan. htakeda@med.id.yamagata-u.ac.jp
Nishise
Shoichi
S
Fukui
Tadahisa
T
Fujishima
Shoichiro
S
Orii
Tomohiko
T
Otake
Sayaka
S
Sato
Takeshi
T
Sasaki
Yu
Y
Kawata
Sumio
S
D000327:Adsorption; D000328:Adult; D001781:Blood Component Removal; D003093:Colitis, Ulcerative / Q000097:blood* / Q000628:therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D016179:Granulocyte Colony-Stimulating Factor