title: Blistering skin conditions.
abstract: BACKGROUND
  Blistering of the skin can be due to a number of diverse aetiologies. Pattern and distribution of blisters can be helpful in diagnosis but usually biopsy is required for histopathology and immunofluoresence to make an accurate diagnosis.
  
  
  OBJECTIVE
  This article outlines the clinical and pathological features of blistering skin conditions with a particular focus on bullous impetigo, dermatitis herpetiformis, bullous pemphigoid and porphyria cutanea tarda.
  
  
  CONCLUSIONS
  Infections, contact reactions and drug eruptions should always be considered. Occasionally blistering may represent a cutaneous manifestation of a metabolic disease such as porphyria. Although rare, it is important to be aware of the autoimmune group of blistering diseases, as if unrecognised and untreated, they can lead to significant morbidity and mortality. Early referral to a dermatologist is important as management of blistering skin conditions can be challenging.
authors: St Vincent's Hospital, Melbourne and Sunbury Dermatology and Skin Cancer Clinic, Sunbury, Victoria. drbwelsh@bigpond.net.au
authors: Belinda
authors: B
authors: Welsh
mesh_terms: D001706:Biopsy / Q000379:methods; D003937:Diagnosis, Differential; D006801:Humans; D007169:Impetigo / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D017119:Porphyria Cutanea Tarda / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology