title: The role of caveolin-1 in prostate cancer: clinical implications.
abstract: Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer.
authors: Department of Genitourinary Medical Oncology-Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. timthomp@mdanderson.org
authors: T C
authors: TC
authors: Thompson
authors: S A
authors: SA
authors: Tahir
authors: L
authors: L
authors: Li
authors: M
authors: M
authors: Watanabe
authors: K
authors: K
authors: Naruishi
authors: G
authors: G
authors: Yang
authors: D
authors: D
authors: Kadmon
authors: C J
authors: CJ
authors: Logothetis
authors: P
authors: P
authors: Troncoso
authors: C
authors: C
authors: Ren
authors: A
authors: A
authors: Goltsov
authors: S
authors: S
authors: Park
mesh_terms: D014408:Biomarkers, Tumor; D051242:Caveolin 1 / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C495540:CAV1 protein, human; D051242:Caveolin 1