title: Organocatalysts immobilised onto gold nanoparticles: application in the asymmetric reduction of imines with trichlorosilane.
abstract: Gold nanoparticles functionalised with a valine-derived formamide have been developed as effective homogenous catalysts for the asymmetric reduction of ketimine 1 with trichlorosilane (< or = 84% ee) in toluene. This methodology both simplifies the recovery of the catalyst and its separation from the product, as the nanoparticles can be readily removed and subsequently recycled by precipitation from the reaction mixture.
authors: WestCHEM, Department of Chemistry, Joseph Black Building, University of Glasgow, Glasgow, UK G12 8QQ. A.Malkov@lboro.ac.uk
authors: Andrei V
authors: AV
authors: Malkov
authors: Marek
authors: M
authors: Figlus
authors: Graeme
authors: G
authors: Cooke
authors: Stuart T
authors: ST
authors: Caldwell
authors: Gouher
authors: G
authors: Rabani
authors: Mark R
authors: MR
authors: Prestly
authors: Pavel
authors: P
authors: Kocovský
mesh_terms: D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism; D008063:Thioctic Acid / Q000737:chemistry
chemical_list: D007097:Imines; D012821:Silanes; D008063:Thioctic Acid; D006046:Gold; C065893:trichlorosilane