Gender and interindividual variability in pharmacokinetics.
Like any other drugs, antiallergic medications can be associated with large inter- and intraindividual variability in their disposition. The best-documented examples belong to the H1 antihistamines. Variable drugs are more likely to show unpredictable therapeutic response with both increased risks of side effects and subtherapeutic dosing in individual subjects. This article will review the main factors contributing to intervariability in pharmacokinetics with a special emphasis on gender differences, genetic polymorphism, and food habits.
Nicolas
Jean-Marie
JM
UCB Pharma SA, Chemin du Foriest, Braine I' Alleud, B-1420 Belgium. Jean-Marie.Nicolas@UCB.com
Espie
Pascal
P
Molimard
Mathieu
M
D018926:Anti-Allergic Agents / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D004032:Diet; D005260:Female; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D011110:Polymorphism, Genetic; D012727:Sex Characteristics; D012907:Smoking; D014018:Tissue Distribution; D016171:Torsades de Pointes / Q000139:chemically induced
D018926:Anti-Allergic Agents; D002352:Carrier Proteins; D006634:Histamine H1 Antagonists; D003577:Cytochrome P-450 Enzyme System