Theoretical study of a membrane channel gated by ATP.
We study channel transport across biomembranes. We propose a model that couples the diffusive dynamics with the gating process via a two-state ratchet mechanism. This gating process is governed by ATP binding and hydrolysis, and the process exhibits Michaelis-Menten enzymatic kinetics. The particle flow and permeability of the channel are studied both analytically and numerically in the steady-state regime, while working between fixed concentrations. The results are compared with simpler models and with experimental data. Also, a simulation framework, that allows high flexibility in parameter exploration, is introduced.
Orlandi
J G
JG
Departament d'Estructura i Constituents de la Matèria, Universitat de Barcelona, E-08028 Barcelona, Spain. orlandi@ecm.ub.es
Sancho
J M
JM
D000255:Adenosine Triphosphate / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002463:Cell Membrane Permeability; D002712:Chlorides / Q000378:metabolism; D006868:Hydrolysis; D015640:Ion Channel Gating; D007473:Ion Channels / Q000378:metabolism*; D008954:Models, Biological
D002712:Chlorides; D007473:Ion Channels; D000255:Adenosine Triphosphate