title: Liver and spleen volume variations in patients with hepatic fibrosis.
abstract: OBJECTIVE
  To study the liver and spleen volume variations in hepatic fibrosis patients at different histopathological stages.
  
  
  METHODS
  Multidetector computed tomography (MDCT) scan was performed in 85 hepatic fibrosis patients. Liver volume (LV) and spleen volume (SV) were measured. Fifteen healthy individuals served as a control group (S0). The patients were divided into stage 1 (S1) group (n = 34), stage 2 (S2) group (n = 25), stage 3 (S3) group (n = 16), and stage 4 (S4) group (n = 10) according to their histopathological stage of liver fibrosis.
  
  
  RESULTS
  The LV and standard LV(SLV)had a tendency to increase with the severity of fibrosis, but no statistical difference was observed in the 5 groups (LV: F = 0.245, P = 0.912; SLV: F = 1.902, P = 0.116). The SV was gradually increased with the severity of fibrosis, and a statistically significant difference in SV was observed among the 5 groups (P < 0.01). The LV/SV ratio and SLV/SV ratio were gradually decreased with the aggravation of hepatic fibrosis, and statistically significant differences in both LV/SV and SLV/SV were found among the 5 groups (P < 0.01).
  
  
  CONCLUSIONS
  The absence of obvious LV reduction in patients with chronic liver disease may be a morphological index of patients without liver cirrhosis. The SV is related to the severity of fibrosis, and the spleen of patients with advanced fibrosis is enlarged evidently. The LV/SV ratio and SLV/SV ratio are of a significant clinical value in the diagnosis of advanced liver fibrosis.
authors: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors: Peng
authors: P
authors: Liu
authors: Peng
authors: P
authors: Li
authors: Wen
authors: W
authors: He
authors: Li-Qin
authors: LQ
authors: Zhao
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008099:Liver / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000473:pathology*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed