Silicate cross-linked bio-nanocomposite hydrogels from PEO and chitosan.
The compositions and the multi phase structures of bio-nanocomposite hydrogels made from silicate cross-linked PEO and chitosan are related to some of their physical and biological properties. The gels are injectable and self-healing because the cross-linking is physical and reversible under deformation. The presence of chitosan aggregates affects the viscoelastic properties and reinforces the hydrogel network. The chitosan adds advantageous properties to the hydrogel such as enhanced cell spreading and adhesion. In vitro biocompatibility data indicate that NIH 3T3 fibroblasts grow and proliferate on the bio-nanocomposite hydrogel as well as on hydrogel films.
Jin
Qu
Q
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907-2032, USA.
Schexnailder
Patrick
P
Gaharwar
Akhilesh K
AK
Schmidt
Gudrun
G
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D053761:Nanocomposites / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012212:Rheology; D033081:Shear Strength; D017640:Silicates / Q000737:chemistry*; D013499:Surface Properties; D055682:Viscoelastic Substances
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020100:Hydrogels; D017640:Silicates; D055682:Viscoelastic Substances; D011092:Polyethylene Glycols; D048271:Chitosan