MYC gene amplification in double minute chromosomes in an aggressive large B-cell lymphoma with leukemic presentation: a case report.
Double-minute chromosomes (dmin) are small chromatin particles that lack a centromere. They represent extrachromosomal form of gene amplification. Dmin are very rarely encountered in lymphoid neoplasms. We describe a case of a leukemic presentation of large B-cell lymphoma with dmin. Fluorescence in situ hybridization analysis identified these dmin as comprising MYC genes.
Alseraye
F
F
Division of Hematopathology and Transfusion Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada. falseraye@ottawahospital.on.ca
Padmore
R
R
Wozniak
M
M
McGowan-Jordan
J
J
D002877:Chromosomes, Human / Q000235:genetics*; D020732:Cytogenetic Analysis; D005784:Gene Amplification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007938:Leukemia / Q000235:genetics*; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008297:Male; D008677:Metaphase; D008875:Middle Aged; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*
D016271:Proto-Oncogene Proteins c-myc