Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma.
OBJECTIVE
To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin's hepatic lymphoma.


METHODS
The research included patients with a diagnosis of Hodgkin's lymphoma with metastatic focal lesions in the liver and controls. Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal, hepatic and splenic veins were examined. Hepatic perfusion index (HPI) estimated by HRA was calculated.


RESULTS
In the majority of patients, hepatomegaly was observed. Lesions were mostly hypoechoic and mixed, solitary or multiple. Some of the patients presented with dilated splenic veins and hepatofugal blood flow. A pulse wave was registered in the centre and at the margins of lymphoma. The average velocity of the pulse wave was higher at the margins (P > 0.05). A continuous venous wave was found only at the margins of lymphoma. There was no linear correlation between lymphoma size and velocity of pulse and continuous wave (r = 390, P < 0.01). HPI was significantly lower in patients with lymphomas than in controls (P < 0.05), pointing out increased arterial perfusion in comparison to portal perfusion.


CONCLUSIONS
Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin's hepatic lymphoma and estimation of its intensity. Hepatic radionuclide angiography can additionally help in the assessment of vascularisation of liver lesions.
Stojković
Mirjana V
MV
Institute for Digestive Diseases Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia.
Artiko
Vera M
VM
Radoman
Irena B
IB
Knezević
Slavko J
SJ
Lukić
Snezana M
SM
Kerkez
Mirko D
MD
Lekić
Nebojsa S
NS
Antić
Andrija A
AA
Zuvela
Marinko M
MM
Ranković
Vitomir I
VI
Petrović
Milorad N
MN
Sobić
Dragana P
DP
Obradović
Vladimir B
VB
D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D011875:Radionuclide Angiography; D018615:Ultrasonography, Doppler, Color