Metabolomics for assessment of nutritional status.
OBJECTIVE
The current rise in diet-related diseases continues to be one of the most significant health problems facing both the developed and the developing world. The use of metabolomics - the accurate and comprehensive measurement of a significant fraction of important metabolites in accessible biological fluids - for the assessment of nutritional status is a promising way forward. The basic toolset, targets and knowledge are all being developed in the emerging field of metabolomics, yet important knowledge and technology gaps will need to be addressed in order to bring such assessment to practice.


RESULTS
Dysregulation within the principal metabolic organs (e.g. intestine, adipose, skeletal muscle and liver) are at the center of a diet-disease paradigm that includes metabolic syndrome, type 2 diabetes and obesity. The assessment of both essential nutrient status and the more comprehensive systemic metabolic response to dietary, lifestyle and environmental influences (e.g. metabolic phenotype) are necessary for the evaluation of status in individuals that can identify the multiple targets of intervention needed to address metabolic disease.


CONCLUSIONS
The first proofs of principle building the knowledge to bring actionable metabolic diagnostics to practice through metabolomics are now appearing.
Zivkovic
Angela M
AM
Department of Food Science and Technology, University of California, Davis, CA 95616, USA.
German
J Bruce
JB
D015415:Biomarkers; D014644:Genetic Variation; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008660:Metabolism / Q000235:genetics* / Q000502:physiology*; D015596:Nutrition Assessment; D009752:Nutritional Status; D010641:Phenotype
D015415:Biomarkers