3-Keto-22-epi-28-nor-cathasterone, a brassinosteroid-related metabolite from Cystoseira myrica.
Bioassay-guided purification of an ethanolic extract of Cystoseira myrica against HEPG-2 (liver) and HCT116 (colon) human cancer cell lines led to the isolation of 3-keto-22-epi-28-nor-cathasterone, 1 and cholest-4-ene-3,6-dione, 2. This finding allowed us to report for the first time that a brassinosteroid-related metabolite occurs in seaweed. These compounds showed activity in the range of 12.38-1.16 microM with selective activity of compound 2 to liver cancer cell lines.
Hamdy
Abdel-Hamid A
AH
Chemistry of Natural and Microbial Products Department, NRC, Cairo, Egypt.
Aboutabl
Elsayed A
EA
Sameer
Somayah
S
Hussein
Ahmed A
AA
Díaz-Marrero
Ana R
AR
Darias
José
J
Cueto
Mercedes
M
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D000459:Phaeophyceae / Q000378:metabolism*; D010840:Phytosterols / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology
C545871:3-keto-28-norcathasterone; D000970:Antineoplastic Agents; D010840:Phytosterols; D013256:Steroids