title: Visceral and subcutaneous adiposity and adiponectin in middle-aged Japanese men: the ERA JUMP study.
abstract: Adiponectin is reduced in obesity and has been suggested to play an important role in modulation of atherosclerosis. We studied the relationship between visceral (VAT) and subcutaneous (SAT) adipose tissue and serum adiponectin concentrations in Japanese men. Participants were 304 randomly selected community-based Japanese men aged 40-49 without a prior history of cardiovascular disease. Participants were grouped according to tertiles of serum adiponectin. In multiple linear regression analysis including age, pack years of smoking, and alcohol intake as covariates, log-transformed adiponectin was inversely associated with both VAT and SAT when these two obesity measures were included separately in the models. However, log-transformed adiponectin was inversely associated with VAT (standardized beta estimate=-0.465; P<0.0001) and positively associated with SAT (standardized beta estimate=1.277; P=0.03), when these were included concomitantly in the model. In conclusion, VAT and SAT had differential associations with serum adiponectin concentrations.
authors: Department of Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan. nakamury@kyoto-wu.ac.jp
authors: Yasuyuki
authors: Y
authors: Nakamura
authors: Akira
authors: A
authors: Sekikawa
authors: Takashi
authors: T
authors: Kadowaki
authors: Aya
authors: A
authors: Kadota
authors: Sayaka
authors: S
authors: Kadowaki
authors: Hiroshi
authors: H
authors: Maegawa
authors: Yoshikuni
authors: Y
authors: Kita
authors: Rhobert W
authors: RW
authors: Evans
authors: Daniel
authors: D
authors: Edmundowicz
authors: J David
authors: JD
authors: Curb
authors: Hirotsugu
authors: H
authors: Ueshima
mesh_terms: D052242:Adiponectin / Q000097:blood; D050154:Adiposity / Q000208:ethnology*; D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D006306:Health Surveys; D006801:Humans; D050152:Intra-Abdominal Fat / Q000503:physiopathology*; D007564:Japan / Q000453:epidemiology; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000208:ethnology* / Q000503:physiopathology; D050151:Subcutaneous Fat / Q000503:physiopathology*; D055105:Waist Circumference
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers