[Genetics and present therapy options in Parkinson's disease: a review].
In the past years, six monogenic forms of Parkinson disease have clearly been associated with this movement disorder. The most frequent forms are LRRK2- and Parkin-associated Parkinson disease. Currently, a genetic diagnosis does not change the therapy, the genes involved in genetic Parkinson disease help to understand the underlying pathophysiologic mechanisms of Parkinson disease. Beside the overview of the molecular-genetic basis, we give a review about genetic testing, pharmacological and other multidisciplinary treatment options.
Bereznai
Benjamin
B
Semmelweis Egyetem, Molekuláris Neurológiai Klinikai és Kutatási Központ, Budapest. bereznaib@neur.sote.hu
Molnar
Mária Judit
MJ
D000978:Antiparkinson Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000379:methods; D003614:Dance Therapy; D046690:Deep Brain Stimulation; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015316:Genetic Therapy; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D009147:Music Therapy; D015513:Oncogene Proteins / Q000235:genetics; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy*; D026741:Physical Therapy Modalities; D000071617:Protein Deglycase DJ-1; D011494:Protein Kinases / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011613:Psychotherapy; D012064:Relaxation Therapy; D044767:Ubiquitin-Protein Ligases / Q000235:genetics; D051844:alpha-Synuclein / Q000235:genetics; D000099202:PTEN-Induced Putative Kinase
D000978:Antiparkinson Agents; D047908:Intracellular Signaling Peptides and Proteins; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D015513:Oncogene Proteins; D000071617:Protein Deglycase DJ-1; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D044767:Ubiquitin-Protein Ligases; D051844:alpha-Synuclein; D000099202:PTEN-Induced Putative Kinase; C111567:parkin protein; C495280:LRRK2 protein, human; C105131:PARK7 protein, human