The effect of ketamine on nerve conduction in isolated sciatic nerves of the toad.
The actions of 100-2500 mug ketamine hydrochloride per ml Ringer solution were examined on the various components of the compound nerve volley of isolated sciatic-tibial nerves of toads. The smaller diameter fibres were blocked first and fibres of progressively larger diameter were blocked with increasing ketamine concentration. A progressive reducton in conduction velocities and amplitude, as well as increasing thresholds, accompanied increased drug contact and concentration. A preliminary trial on human volunteers revealed an apparent loss of pain and thermal sensations following subcutaneous injection.
Weber
W V
WV
Department of Physiology, University of Nigeria, Enugu Campus, Enugu, E.C.S., Nigeria.
Jawalekar
K S
KS
Jawalekar
S R
SR