Serum proinflammatory cytokine - interleukin-8 as possible infection site marker in preterm deliveries.
OBJECTIVE
To evaluate serum level of proinflammatory cytokine interleukin-8 as a biochemical marker of local infections in patients with clinical symptoms of preterm deliveries.


METHODS
We studied 74 pregnant women at 24-36 gestational weeks (GW) with preterm delivery. Serum interleukin-8 was measured.


RESULTS
The mean value of interleukin-8 in the study group (n=36) was 19.13 pg/mL vs. 5.02 pg/mL in the controls (n=38).


CONCLUSIONS
The results indicate that serum level of interleukin-8 might be used as non-invasive marker of infections in pregnancy, as well as a marker of preterm deliveries.
Bogavac
Mirjana A
MA
Department for Infection Diseases, Clinical Center Vojvodina, Novi Sad, Serbia, Serbia and Montenegro. mbogavac@yahoo.com
Brkić
Snezana
S
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D018836:Inflammation Mediators / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D007752:Obstetric Labor, Premature / Q000097:blood* / Q000209:etiology / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D014591:Uterine Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D055815:Young Adult
D015415:Biomarkers; C508606:CXCL8 protein, human; D018836:Inflammation Mediators; D016209:Interleukin-8