Clinical parameters linked with malignancy in endometrial polyps.
OBJECTIVE
To investigate the association of different clinical parameters with the histological diagnosis and the prevalence of premalignant and malignant endometrial polyps.


METHODS
The study included 516 cases from January 2002 to December 2006. Possible risk factors such as age, menopause status, abnormal bleeding, obesity, hypertension, diabetes mellitus, hormone therapy, use of tamoxifen and size of polyp were investigated in relation to their association with the malignant potential of endometrial polyps.


RESULTS
All cases of endometrial polyps underwent hysteroscopic resection; 96.9% of the cases were benign, 1.2% premalignant and 1.9% malignant. Premalignant and malignant endometrial polyps were significantly associated with advanced age (>60 years), menopause, obesity and diabetes. The malignant polyps were analyzed to eight endometrioid, one serous and one clear cell carcinoma.


CONCLUSIONS
The prevalence of premalignant and malignant endometrial polyps is very low. Advanced age, menopause, obesity and diabetes increase the risk of endometrial polyp malignancy.
Gregoriou
O
O
2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of Athens Medical School, Athens, Greece.
Konidaris
S
S
Vrachnis
N
N
Bakalianou
K
K
Salakos
N
N
Papadias
K
K
Kondi-Pafiti
A
A
Creatsas
G
G
D018262:Adenocarcinoma, Clear Cell / Q000453:epidemiology / Q000473:pathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000453:epidemiology / Q000473:pathology; D048909:Diabetes Complications; D004714:Endometrial Hyperplasia / Q000453:epidemiology / Q000473:pathology; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D011127:Polyps / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D014592:Uterine Hemorrhage / Q000453:epidemiology