Integration of metabolic reactions and gene regulation.
Metabolic reactions and gene regulation are two primary processes of cells. In response to environmental changes cells often adjust the regulatory programs and shift the metabolic states. An integrative investigation and modeling of these two processes would improve our understanding of the cellular systems and may generate substantial impacts in medicine, agriculture, environmental protection, and energy. We review the studies of the various aspects of the crosstalk between metabolic reactions and gene regulation, including models, empirical evidence, and available databases.
Yeang
Chen-Hsiang
CH
Institute of Statistical Science, Academia Sinica, Nankang, Taipei, Taiwan, ROC.
D000818:Animals; D019992:Databases as Topic; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics / Q000502:physiology*; D008660:Metabolism / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods*; D018511:Systems Integration