Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels.
Heart-type fatty acid-binding protein (H-FABP) is widely distributed and has been used to diagnose certain diseases. However, its alteration during infection-evoked organ dysfunction, and the potential association between leptin and it in injury or infection has not been investigated. In the current study, serum H-FABP, leptin, C-reactive protein and interleukin-1beta in the patients with pulmonary infection-induced multiple organ dysfunction were detected. Moreover, a mouse model of sepsis was established, and serum alanine transaminase, uric acid, tissue H-FABP, myeloperoxidase, superoxide dismutase activity and histological alterations in lung and intestine were investigated. Serum H-FABP and leptin increased simultaneously and significantly in the patients, and leptin alleviated pulmonary and intestinal injuries by restraining tissue H-FABP secretions in the mouse model of sepsis. Other investigated variables showed different but independent alterations. In conclusion, H-FABP represents a useful diagnostic marker for organ dysfunction, and its association with leptin will be a novel target for emergency aid.
Yan
Guang-tao
GT
Research Laboratory of Biochemistry, Basic Medical Institute, Chinese PLA General Hospital, Beijing, PR China. yan301@263.net
Lin
Ji
J
Hao
Xiu-hua
XH
Xue
Hui
H
Zhang
Kai
K
Wang
Lu-huan
LH
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000032:analysis / Q000097:blood* / Q000378:metabolism*; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D020738:Leptin / Q000097:blood / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D009195:Peroxidase / Q000097:blood; D011817:Rabbits; D011863:Radioimmunoassay; D015203:Reproducibility of Results; D018805:Sepsis / Q000150:complications* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood; D014527:Uric Acid / Q000097:blood
D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D053583:Interleukin-1beta; D020738:Leptin; D014527:Uric Acid; D002097:C-Reactive Protein; D009195:Peroxidase; D013482:Superoxide Dismutase; D000410:Alanine Transaminase