title: Extracorporeal membrane oxygenation and term neonatal respiratory failure deaths in the United Kingdom compared with the United States: 1999 to 2005.
abstract: OBJECTIVE
  To compare national neonatal extracorporeal membrane oxygenation data and deaths from primary respiratory disorders of term neonates between the United Kingdom and the United States from 1999 to 2005.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  National data sets from the United Kingdom and the United States.
  
  
  METHODS
  Neonatal extracorporeal membrane oxygenation patients submitted to the Extracorporeal Life Support Organization Registry and national birth and death registrations.
  
  
  METHODS
  None.
  
  
  RESULTS
  Meconium aspiration syndrome was the most common indication for extracorporeal membrane oxygenation in the United Kingdom: 50.6% vs. 25.8% in the United States (p < .001). Congenital diaphragmatic hernia was most common indication for extracorporeal membrane oxygenation in the United States: 30.7% vs. 15.4% in the United Kingdom (p < .001).Extracorporeal membrane oxygenation use was greater in the United States than the United Kingdom: rate ratio, 1.81 (95%, confidence interval, 1.64, 2.00). The extracorporeal membrane oxygenation rate decreased over time in the United States (p < .001) but was unchanged for all diagnoses in the United Kingdom (p = .49). The rates of extracorporeal membrane oxygenation use for meconium aspiration syndrome were equivalent in both countries: rate ratio, 0.92 (95% confidence interval, 0.80, 1.07) but greater in the United States for congenital diaphragmatic hernia: rate ratio, 3.60, (95% confidence interval, 2.82, 4.66) and persistent pulmonary hypertension newborn: rate ratio, 4.67 (95% confidence interval, 3.33, 6.74).National neonatal death rates included nonextracorporeal membrane oxygenation + extracorporeal membrane oxygenation death. Meconium aspiration syndrome deaths were equivalent overall between the two countries: rate ratio, 0.99 (95% confidence interval, 0.77, 1.29), but decreased in the United States (p < .001) although not in the United Kingdom (p = .17). Congenital diaphragmatic hernia deaths were more prevalent in the United Kingdom than in the United States: rate ratio, 1.57 (95% confidence interval, 1.34, 1.84).
  
  
  CONCLUSIONS
  Extracorporeal membrane oxygenation is used more often in the United States: clinicians seem less willing to offer extracorporeal membrane oxygenation for persistent pulmonary hypertension of the newborn and congenital diaphragmatic hernia in the United Kingdom. In contrast to the United States, no reduction in either extracorporeal membrane oxygenation use or death due to meconium aspiration syndrome was observed in the United Kingdom. Early transfer to a tertiary center is recommended for term neonates with respiratory failure.
authors: Cardiac Critical Care, Great Ormond Street Hospital for Children, London, UK. BrownK@gosh.nhs.uk
authors: Kate L
authors: KL
authors: Brown
authors: Sudhir
authors: S
authors: Sriram
authors: Deborah
authors: D
authors: Ridout
authors: Jane
authors: J
authors: Cassidy
authors: Hitesh
authors: H
authors: Pandya
authors: Morag
authors: M
authors: Liddell
authors: Carl
authors: C
authors: Davis
authors: Allan
authors: A
authors: Goldman
authors: David
authors: D
authors: Field
authors: Ann
authors: A
authors: Karimova
mesh_terms: D003430:Cross-Sectional Studies; D015199:Extracorporeal Membrane Oxygenation / Q000706:statistics & numerical data*; D006801:Humans; D007226:Infant Mortality / Q000639:trends*; D007231:Infant, Newborn; D012131:Respiratory Insufficiency / Q000401:mortality* / Q000628:therapy; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology