title: Cyclooxygenase-2 immunoreactivity and protein level in the gerbil hippocampus during normal aging.
abstract: Cyclooxygenases-2 (COX-2) is not only related to inflammation but also plays critical roles in brain development and synaptic signaling. In the present study, we investigated age-related changes in COX-2 immunoreactivity and protein levels in the gerbil hippocampus. In the hippocampal CA1 region (CA1) and dentate gyrus (DG), weak COX-2 immunoreactivity was observed at postnatal month 1 (PM 1), and COX-2 immunoreactivity was markedly increased at PM 18 and 24. In the CA2/3, COX-2 immunoreactivity was strong at PM 1. COX-2 immunoreactivities in the PM 3, 6 and 12 groups were decreased compared to that in the PM 1 group, and it was increased at PM 18 and 24. In addition, age-related changes in COX-2 levels were similar with immunohistochemical results in the CA2/3. These results suggest that COX-2 immunoreactivity and levels were high in the hippocampus of aged gerbils.
authors: Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200-702, South Korea.
authors: Choong Hyun
authors: CH
authors: Lee
authors: Ki-Yeon
authors: KY
authors: Yoo
authors: Jung Hoon
authors: JH
authors: Choi
authors: Ok Kyu
authors: OK
authors: Park
authors: In Koo
authors: IK
authors: Hwang
authors: Il-Jun
authors: IJ
authors: Kang
authors: Moo-Ho
authors: MH
authors: Won
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005849:Gerbillinae; D006624:Hippocampus / Q000201:enzymology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D051546:Cyclooxygenase 2