Elevated erythrocyte phospholipase A associated with Duchenne and myotonic muscular dystrophy.
Erythrocytes from patients with Duchenne or myotonic muscular dystrophy exhibit substantially increased phospholipase A activity when compared to those from normal subjects. Incubation of dystrophic erythrocyte membranes with diphenylhydantoin lowers the phospholipase A activity to within normal limits while the drug does not diminish activity in membranes from normal cells. Elevated phospholipase A activity may be expected to lead to increased concentrations of lysophospholipids which may contribute to the membrane dysfunction shown to be associated with these diseases.
Iyer
S L
SL
Committee on Biochemistry, Bowdoin College, Brunswick, Maine 04011, USA.
Katyare
S S
SS
Howland
J L
JL