title: NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity.
abstract: The NASA Study of Cataract in Astronauts (NASCA) is a 5-year longitudinal study of the effect of space radiation exposure on the severity/progression of nuclear, cortical and posterior subcapsular (PSC) lens opacities. Here we report on baseline data that will be used over the course of the longitudinal study. Participants include 171 consenting astronauts who flew at least one mission in space and a comparison group made up of three components: (a) 53 astronauts who had not flown in space, (b) 95 military aircrew personnel, and (c) 99 non-aircrew ground-based comparison subjects. Continuous measures of nuclear, cortical and PSC lens opacities were derived from Nidek EAS 1000 digitized images. Age, demographics, general health, nutritional intake and solar ocular exposure were measured at baseline. Astronauts who flew at least one mission were matched to comparison subjects using propensity scores based on demographic characteristics and medical history stratified by gender and smoking (ever/never). The cross-sectional data for matched subjects were analyzed by fitting customized non-normal regression models to examine the effect of space radiation on each measure of opacity. The variability and median of cortical cataracts were significantly higher for exposed astronauts than for nonexposed astronauts and comparison subjects with similar ages (P=0.015). Galactic cosmic space radiation (GCR) may be linked to increased PSC area (P=0.056) and the number of PSC centers (P=0.095). Within the astronaut group, PSC size was greater in subjects with higher space radiation doses (P=0.016). No association was found between space radiation and nuclear cataracts. Cross-sectional data analysis revealed a small deleterious effect of space radiation for cortical cataracts and possibly for PSC cataracts. These results suggest increased cataract risks at smaller radiation doses than have been reported previously.
authors: Center for Ophthalmic Research, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. ltchylack@rics.bwh.harvard.edu
authors: Leo T
authors: LT
authors: Chylack
authors: Leif E
authors: LE
authors: Peterson
authors: Alan H
authors: AH
authors: Feiveson
authors: Mary L
authors: ML
authors: Wear
authors: F Keith
authors: FK
authors: Manuel
authors: William H
authors: WH
authors: Tung
authors: Dale S
authors: DS
authors: Hardy
authors: Lisa J
authors: LJ
authors: Marak
authors: Francis A
authors: FA
authors: Cucinotta
mesh_terms: D000328:Adult; D000401:Aircraft; D018480:Astronauts; D002386:Cataract / Q000209:etiology; D003359:Cosmic Radiation / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology / Q000528:radiation effects; D007904:Lens Cortex, Crystalline / Q000473:pathology / Q000528:radiation effects; D007907:Lens Nucleus, Crystalline / Q000473:pathology / Q000528:radiation effects; D007908:Lens, Crystalline / Q000473:pathology* / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000150:complications; D013026:Space Flight; D014481:United States; D018557:United States National Aeronautics and Space Administration