title: Luteolin ameliorates ferric nitrilotriacetic acid induced renal toxicity and tumor promotional response in rat.
abstract: Ferric nitrilotriacetic acid (Fe-NTA) (9 mg Fe/kg body weight, i.p.) caused significant depletion in the detoxification and antioxidant enzyme armory with concomitant elevation in renal lipidperoxidation, serum toxicity markers viz. creatinine, blood urea nitrogen, hydrogen peroxide generation, ornithine decarboxylase activity and [3H] thymidine incorporation into renal DNA in wistar rats. However, pretreatment of animals with luteolin (10 and 20 micromol/kg body weight) for 7 consecutive days resulted in significant decrease in above parameters level. Renal glutathione content, glutathione metabolizing enzymes and antioxidant enzymes were also recovered to significant level. The enhanced reduced glutathione level and enzyme activities involved in xenobiotic metabolism and maintaining antioxidant status of cells is suggestive of a chemopreventive efficacy of luteolin against Fe-NTA mediated oxidative stress, toxicity and cell proliferation response in rats.
authors: Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110 062, India. sarwat786@rediffmail.com
authors: Sarwat
authors: S
authors: Sultana
authors: Lakshmi
authors: L
authors: Prasad
authors: Tamanna
authors: T
authors: Jahangir
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002273:Carcinogens / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D047311:Luteolin / Q000494:pharmacology*; D008297:Male; D009571:Nitrilotriacetic Acid / Q000737:chemistry / Q000633:toxicity*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016588:Anticarcinogenic Agents; D002273:Carcinogens; D009571:Nitrilotriacetic Acid; D047311:Luteolin