title: [Clinical and pathological features of operable breast cancer in women over 65 years].
abstract: OBJECTIVE
  To study the clinical and pathological characteristics of operable breast cancer in women over 65 years.
  
  
  METHODS
  The data of 95 patients treated from February 2003 to February 2005 were collected, and the clinicopathological characteristics were retrospectively analyzed.
  
  
  RESULTS
  These 95 patients accounted for 26.1% of all female breast cancer patients registered in our hospital in the mean time. Local advanced breast cancer accounted for 74.5% of the patients. The median time from symptom presentation to treatment seeking was 1.2 years. Curative resection was performed in 96 breasts of 94 patients, 71 patients received chemotherapy and 67 received endocrine therapy. Sixty-four cases (67.3%) were confirmed invasive ductal carcinoma. Positive expression of estrogen or progesterone receptor was found in 65 cases (68.4%); overexpression of C-erbB-2 was found in 23.5% of the patients and low level expression of Ki-67 (<30%) was found in 54.1% of the cases, respectively. The 3-year overall survival rate and disease free survival rate was 87.4% and 71.4%, respectively.
  
  
  CONCLUSIONS
  Of the breast cancer in aged women, most are local advanced breast cancer. Breast cancer in the elderly women has distinctive clinicopathological characteristics. Less radical surgery combined with adjuvant chemotherapy and(or) endocrine therapy is feasible treatment.
authors: General Surgical Department, Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences, Beijing 100050, China.
authors: Zhu
authors: Z
authors: Yuan
authors: Xiang
authors: X
authors: Qu
authors: Zhong-tao
authors: ZT
authors: Zhang
authors: Jian-she
authors: JS
authors: Li
authors: Chang-sheng
authors: CS
authors: Teng
authors: Yu
authors: Y
authors: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate