title: Elevated erythropoietin in vitreous of patients with rhegmatogenous retinal detachment and proliferative vitreoretinopathy.
abstract: OBJECTIVE
  Our purpose was to determine the vitreous erythropoietin (EPO) level in patients with rhegmatogenous retinal detachment (RRD) and proliferative vitreoretinopathy (PVR).
  
  
  METHODS
  The levels of EPO in vitreous were measured using a sandwich enzyme-linked immunosorbent assay kit from 64 patients, of whom 40 had RRD, 13 had PVR and 11 had idiopathic macular hole as control.
  
  
  RESULTS
  The mean levels of EPO in the RRD group (54.6 +/- 7.3 mU/ml) and PVR group (104.1 +/- 20.8 mU/ml) were significantly higher than that in the idiopathic macular hole control group (14.4 +/- 3.6 mU/ml; p < 0.001, p = 0.003, respectively). The mean EPO level in PVR was higher than that in RRD, but the difference was not significant (p = 0.112).
  
  
  CONCLUSIONS
  The vitreous EPO level was upregulated in eyes with RRD and PVR.
authors: Department of Ophthalmology, Zhejiang University School of Medicine, Hangzhou, China.
authors: Zhao-Yang
authors: ZY
authors: Wang
authors: Li-Jun
authors: LJ
authors: Shen
authors: Ke-Ke
authors: KK
authors: Zhao
authors: Zong-Ming
authors: ZM
authors: Song
authors: Jia
authors: J
authors: Qu
mesh_terms: D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D004921:Erythropoietin / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D008875:Middle Aged; D012163:Retinal Detachment / Q000378:metabolism*; D012167:Retinal Perforations / Q000378:metabolism; D018630:Vitreoretinopathy, Proliferative / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D004921:Erythropoietin