Dramatic response to platinum in a patient with cancer with a germline BRCA2 mutation.
We present a case of dramatic response of poor prognosis cancer in a lady with a germline mutation in the BRCA2 gene who was exposed to platinum containing chemotherapy. She is cancer-free 10 years' later. Such cases provide clinical scenarios for the basis of trials of platinum-like agents in individuals with BRCA mutations who develop cancer.
Moule
R
R
Radiotherapy Department, University College Hospital, London NW1 2BU, UK.
Sohaib
A
A
Eeles
R
R
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D024522:Genes, BRCA2; D018095:Germ-Line Mutation; D006801:Humans; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D011379:Prognosis
D009944:Organoplatinum Compounds