Trisomy 8 in two newly diagnosed Chinese patients with chronic lymphocytic leukemia.
Chronic lymphocytic leukemia (CLL) is one of the most common lymphoid malignancies in Western countries, but is infrequent in Asian populations. To verify the incidence of trisomy 8 in Chinese patients with CLL, fluorescence in situ hybridization (FISH) was used in 140 CLL patients after routine chromosome analysis. Only two patients (1.4%) were found with trisomy 8, and the number of trisomy 8 cells was 8 and 10%, respectively. No other aberrations by "panel" probe FISH were found in these two patients. The chromosome karyotypes of two patients were 47,XY,+8[2]/49,XY,+14,+20,+21[2]/46,XY[16] and 47,XX,+8[2]/46,XX[18], respectively. Neither of the patients' present signs of myelodysplastic or myeloproliferative disorder appeared on the bone marrow aspirates and peripheral blood smear. Our study demonstrates that trisomy 8 is rare in CLL, and its role in prognosis of CLL remains unknown.
Xu
Wei
W
Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing, China.
Cao
Xin
X
Liu
Qiong
Q
Fan
Lei
L
Miao
Kou-Rong
KR
Qiu
Hai-Rong
HR
Zhu
Dan-Xia
DX
Qiu
Hong-Xia
HX
Li
Jian-Yong
JY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002681:China; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy / Q000175:diagnosis* / Q000235:genetics*