title: [In vivo delivery of siRNA].
abstract: RNA interference (RNAi) is a mechanism of posttranscriptional gene silencing mediated by small interfering RNA (siRNA). The ability of synthetic siRNA to silence genes in vivo has made it well suited as therapeutic drug, but the instability and polarity of siRNA and the complexity of in vivo circumstances retarded rapid development of RNAi-based therapies. In this review, a summary of the advances on in vivo siRNA delivery is presented and discussed.
authors: Beijing Institute of Biotechnology, Beijing 100071, China. shiml1@yahoo.com.cn
authors: Ming-Lei
authors: ML
authors: Shi
authors: Zhi-Hu
authors: ZH
authors: Zhao
authors: Yang
authors: Y
authors: Wang
authors: Hui-Peng
authors: HP
authors: Chen
mesh_terms: D000818:Animals; D000906:Antibodies / Q000378:metabolism; D005822:Genetic Vectors / Q000378:metabolism; D006801:Humans; D053758:Nanoparticles; D010455:Peptides / Q000378:metabolism; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000378:metabolism*
chemical_list: D000906:Antibodies; D010455:Peptides; D034741:RNA, Small Interfering