Prognostic role of vascularisation and proliferation in rectal cancer with liver metastasis.
OBJECTIVE
The present study was designed to provide an analysis of factors for tumor vascularisation and proliferation in 37 rectal cancer patients with concurrent and recurrent liver metastasis underwent preoperative radiotherapy, surgery and adjuvant chemotherapy with emphasis on the time of presence of hepatic spread.


METHODS
Immunohistochemistry was used for expression of proliferation (MIB-1) and for detection of microvessel density (MVD, expressed by CD34). Clinicopathological findings were compared with outcome with emphasis on IHC.


RESULTS
A vascular enumeration, pN status and the time of presence of the metastases has shown prognostic role along with the factors above. Increased proliferative activity of the tumor as expressed by MIB-1 staining had no prognostic value, similarly to the localization of tumor, gender, age or grading.


CONCLUSIONS
Higher pN status and tumor vascularisation has been linked to poor prognosis in overall survival and recurrence of liver metastases.
Bognar
Gabor
G
2th Department of Surgery, Semmelweis University, Budapest, Hungary. bgabor68@gmail.com
Ledniczky
György
G
Tóth
Katalin E
KE
Ondrejka
Pál
P
Tamás
Róbert
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D016014:Linear Models; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012004:Rectal Neoplasms / Q000473:pathology* / Q000628:therapy; D012307:Risk Factors; D015996:Survival Rate