title: Ultrasound-assisted one-pot, three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones.
abstract: Triethylamine was found to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in ethanol under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of ethanol as a solvent that is considered to be relatively environmentally benign.
authors: Department of Chemistry, Shahid Beheshti University, G.C., P.O. Box 19396-4716, Tehran, Iran.
authors: Mohammad Reza
authors: MR
authors: Nabid
authors: Seyed Jamal Tabatabaei
authors: SJ
authors: Rezaei
authors: Ramin
authors: R
authors: Ghahremanzadeh
authors: Ayoob
authors: A
authors: Bazgir
mesh_terms: D002384:Catalysis; D000431:Ethanol / Q000737:chemistry* / Q000528:radiation effects; D005021:Ethylamines / Q000737:chemistry* / Q000528:radiation effects*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000528:radiation effects*; D011829:Radiation Dosage; D013010:Sonication / Q000379:methods*
chemical_list: D005021:Ethylamines; D011724:Pyridazines; C100108:diftalone; D000431:Ethanol; C016162:triethylamine