Elevated anticardiolipin antibodies in schizophrenic patients before and during neuroleptic medication.
The objective of this study was to examine the prevalence of IgG and IgM anticardiolipin antibodies (aCL) in schizophrenic patients and to determine the relation of aCL levels with neuroleptic medication and psychotic symptoms. Twenty-three patients with acute episodes of chronic schizophrenia, drug-free for at least 3 months before entering the study, were tested for aCL at admission (T1) and 42 days (T2) after neuroleptic treatment started. Blood samples were taken from 20 healthy volunteers as well. Diagnosis was performed according to DSM-IV. Serum samples were analysed for IgG and IgM autoantibodies against beta2-glycoprotein-1-cardiolipin complex by commercially available ELISA kits (Binding-site, UK). Significantly higher levels of aCL antibodies of both isotypes were found in schizophrenic patients versus controls. In patients IgM-aCL positivity was significantly more frequent than in controls. The elevated IgM-aCL and IgG-aCL values were not associated with neuroleptic treatment and psychotic symptoms, as measured by the Positive and Negative Syndrome Scale and the Pentagonal Structural Model of Schizophrenic Symptoms. The negative correlation of IgM-aCL and IgG-aCL with the positive symptoms scale and the autistic preoccupation scale (Pentagonal Structural Model) may indicate the consumption of these antibodies in the exacerbation of the disease.
Halacheva
Krasimira
K
Department of Clinical Immunology, Medical Faculty, Thracian University, Stara Zagora, Bulgaria.
Dimova
Svetlana
S
Tolev
Todor
T
Dimov
Dimo
D
Nikolova
Maria
M
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002308:Cardiolipins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors
D017153:Antibodies, Anticardiolipin; D014150:Antipsychotic Agents; D002308:Cardiolipins; D007074:Immunoglobulin G; D007075:Immunoglobulin M