Injectable hyaluronan for the treatment of carpometacarpal osteoarthritis: open label pilot trial.
OBJECTIVE
Carpometacarpal osteoarthritis (CMC OA) is highly prevalent in older adults, and is often unresponsive to medical treatment. Intra-articular Hylan G-F 20 has been shown to improve pain and function in patients with knee OA; however, its effectiveness in CMC OA is less clear.


METHODS
32 patients with CMC OA were injected with Hylan G-F 20, once weekly for three consecutive weeks. Patients were assessed 4, 12, 20 and 26 weeks after the first injection. A last-value carried forward analysis was performed.


RESULTS
Average age was 64 years, (range 46-79), 69% were female and 97% Caucasian. Fifty-three percent had at least one previous corticosteroid injection in the affected CMC joint. At 26 weeks, mean visual analogue scale (VAS) for pain had improved significantly (15.2 mm; p-value = 0.006). Disabilities of the arm, shoulder and hand questionnaire (DASH) scores also improved significantly (12.6; p-value < 0.001). A DASH change of 10-14 is considered clinically meaningful. Neither key strength nor opposition grip strength improved. VAS scores for pain at 26 weeks showed good correlation with patient satisfaction (Spearman r = 0.52, p-value < 0.01). Adverse events potentially related to the injections included three episodes of post-injection pain and swelling, and one case of crystal proven pseudogout.


CONCLUSIONS
Intra-articular Hylan G-F 20 injections reduced pain and improved function in patients with CMC OA at 26 weeks in this small open label study. Limitations of this study include its small, open label design. Larger randomized controlled trials are needed to confirm these results, and to determine predictors of response to treatment.


BACKGROUND
This study was approved by the Institutional Review Board at the Hospital for Special Surgery, New York, NY, USA and registered at (www.ClinicalTrials.Gov)# NCT00198029.
Mandl
Lisa A
LA
Hospital for Special Surgery, New York, NY 10021, USA. mandll@hss.edu
Hotchkiss
Robert N
RN
Adler
Ronald S
RS
Lyman
Stephen
S
Daluiski
Aaron
A
Wolfe
Scott W
SW
Katz
Jeffrey N
JN
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects; D000368:Aged; D052737:Carpometacarpal Joints / Q000187:drug effects / Q000473:pathology; D004487:Edema / Q000453:epidemiology / Q000209:etiology; D005260:Female; D018737:Hand Strength; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy* / Q000473:pathology; D010146:Pain / Q000453:epidemiology / Q000209:etiology; D017060:Patient Satisfaction; D010865:Pilot Projects
D000276:Adjuvants, Immunologic; D006820:Hyaluronic Acid