Cadmium concentrations in blood and seminal plasma: correlations with sperm number and motility in three male populations (infertility patients, artificial insemination donors, and unselected volunteers).
To investigate a possible common environmental exposure that may partially explain the observed decrease in human semen quality, we correlated seminal plasma and blood cadmium levels with sperm concentration and sperm motility. We studied three separate human populations: group 1, infertility patients (Long Island, NY, USA); group 2, artificial insemination donors (AID) (Rochester, NY, USA); and group 3, general population volunteers (Rochester, NY, USA). Information about confounding factors was collected by questionnaire. Seminal plasma cadmium did not correlate with blood cadmium (Spearman correlation, n = 91, r = -0.092, P = 0.386, NS). Both blood and seminal plasma cadmium were significantly higher among infertility patients than the other subjects studied (for example, median seminal plasma cadmium was 0.282 microg/L in infertility patients versus 0.091 microg/L in AID and 0.092 microg/L in general population volunteers; Kruskal-Wallis test, P < 0.001). The percentage of motile sperm and sperm concentration correlated inversely with seminal plasma cadmium among the infertility patients (r = -0.201, P < 0.036 and r = -0.189, P < 0.05, respectively), but not in the other two groups. Age (among infertility patients) was the only positive confounder correlating with seminal plasma cadmium. To validate our human findings in an animal model, we chronically exposed adolescent male Wistar rats to low-moderate cadmium in drinking water. Though otherwise healthy, the rats exhibited decreases in epididymal sperm count and sperm motility associated with cadmium dose and time of exposure. Our human and rat study results are consistent with the hypothesis that environmental cadmium exposures may contribute significantly to reduced human male sperm concentration and sperm motility.
Benoff
Susan
S
Fertility Research Laboratories, The Feinstein Institute for Medical Research, Manhasset, New York 11030, United States of America. Sbenoff@optonline.net
Hauser
Russ
R
Marmar
Joel L
JL
Hurley
Ian R
IR
Napolitano
Barbara
B
Centola
Grace M
GM
D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002104:Cadmium / Q000097:blood / Q000378:metabolism* / Q000633:toxicity; D002105:Cadmium Poisoning / Q000097:blood / Q000378:metabolism*; D004195:Disease Models, Animal; D004781:Environmental Exposure; D006801:Humans; D007248:Infertility, Male / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012661:Semen / Q000378:metabolism*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D018709:Statistics, Nonparametric; D014019:Tissue Donors
D015415:Biomarkers; D002104:Cadmium