title: Acute stress augments innate immunity in the liver and increases hyaluronan levels in the tissues and blood of mice.
abstract: The effect of acute stress on the immune system was examined in mice. Restraint stress decreased the number of lymphocytes in the liver, whereas the number of lymphocytes remained unchanged in the spleen and thymus. In the liver, the decrease in number appeared at 1.5 h and fell to a third of he control level at 3 h. The proportions of IL-2Rbeta(+)CD3(int) cells, NKT cells, CD44(+) T cells and B cells were changed in the liver. The absolute numbers of IL-2Rbeta(+)CD3(int) cells, NKT cells and CD3(+)CD44(+) cells remained constant in the liver under the stress, while those of total T cells and NK cells decreased. The levels of hyaluronan (HA) in various tissues and sera were then examined. The expression of hyaluronan binding protein (HABP) was found to increase in the skin, liver and kidney as shown by immunohistochemical staining. An increase of HA in sera due to stress was seen at 3 h. The present results suggest that the activation of CD44(+) T cells and unconventional T cells (i.e., innate immunity) in the blood and the elevated levels of HA (ligand for CD44) in the tissues and blood are crucial responses to acute stress exposure.
authors: Department of Immunology, Niigata University School of Medicine, Niigata, Japan.
authors: Masashi
authors: M
authors: Inoue
authors: Yuh
authors: Y
authors: Kuwano
authors: Chikako
authors: C
authors: Tomiyama-Miyaji
authors: Mayumi
authors: M
authors: Watanabe
authors: Eisuke
authors: E
authors: Kainuma
authors: Hongwei
authors: H
authors: Ren
authors: Jiwei
authors: J
authors: Shen
authors: Kyosuke
authors: K
authors: Miyazaki
authors: Toru
authors: T
authors: Abo
mesh_terms: D000818:Animals; D002469:Cell Separation; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics / Q000378:metabolism; D000076002:Hyaluronan Synthases; D006820:Hyaluronic Acid / Q000378:metabolism*; D007113:Immunity, Innate / Q000502:physiology*; D008099:Liver / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012149:Restraint, Physical / Q000523:psychology*; D013312:Stress, Physiological / Q000276:immunology*; D013315:Stress, Psychological / Q000276:immunology*; D014018:Tissue Distribution
chemical_list: D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid; D014453:Glucuronosyltransferase; C491099:Has2 protein, mouse; D000076002:Hyaluronan Synthases