Body composition, cardiorespiratory fitness, and low-grade inflammation in middle-aged men and women.
The objective of the present study was to determine the respective contributions of visceral adipose tissue (AT) accumulation and cardiorespiratory fitness to variation of inflammatory markers in men and women. Circulating levels of C-reactive protein, tumor necrosis factor-alpha, interleukin-6, and adiponectin were obtained with visceral AT (computed tomography) and fitness (physical working capacity test) levels in a sample of healthy men (n = 120) and women (n = 152) covering a wide range of adiposity. An inflammation score was developed based on gender-specific percentile values of each inflammatory marker (0 or 1), which yielded a score ranging from 0 (low) to 4 (high). Visceral AT was positively associated with C-reactive protein and interleukin-6 levels (r > or =0.35, p <0.0001), but negatively associated with adiponectin (r = -0.29, p < or =0.0003) after adjustment for fitness. After adjusting for visceral AT, fitness was not associated with variation in inflammatory markers in women and only with adiponectin in men (r = -0.20, p = 0.03). In participants with low visceral AT (<130 cm(2) for men and <100 cm(2) for women), prevalences of participants with an increased inflammation score were 23.9% and 28.0%, respectively, for participants with high and low fitness, whereas in subjects with increased visceral AT, prevalences of a high inflammation score were 60.0% and 61.7%, respectively, for participants with high and low fitness. In conclusion, these results suggest that the previously reported association between poor fitness and low-grade inflammation may be largely attributable to increased visceral AT accumulation and its associated state of insulin resistance, conditions frequently observed in subjects with poor cardiorespiratory fitness.
Arsenault
Benoit J
BJ
Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, Québec, Canada.
Cartier
Amélie
A
Côté
Mélanie
M
Lemieux
Isabelle
I
Tremblay
Angelo
A
Bouchard
Claude
C
Pérusse
Louis
L
Després
Jean-Pierre
JP
D052242:Adiponectin / Q000097:blood; D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers; D001823:Body Composition; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002320:Cardiovascular Physiological Phenomena; D017079:Exercise Tolerance; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007333:Insulin Resistance; D007378:Interleukins / Q000097:blood; D050152:Intra-Abdominal Fat / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010809:Physical Fitness; D012143:Respiratory Physiological Phenomena; D013223:Statistics as Topic; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D052242:Adiponectin; D015415:Biomarkers; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein