title: Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol.
authors: Johann Wolfgang Goethe-University, Frankfurt am Main, Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
authors: Sridhar
authors: S
authors: Sreeramulu
authors: Santosh Lakshmi
authors: SL
authors: Gande
authors: Michael
authors: M
authors: Göbel
authors: Harald
authors: H
authors: Schwalbe
mesh_terms: D001665:Binding Sites; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018833:Chaperonins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D053978:Pentacyclic Triterpenes; D017510:Protein Folding; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C498362:CDC37 protein, human; D018797:Cell Cycle Proteins; D018841:HSP90 Heat-Shock Proteins; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D018833:Chaperonins; C050414:celastrol