title: Current concepts in the pathophysiology of glaucoma.
abstract: Glaucoma, the second leading cause of blindness, is characterized by changes in the optic disc and visual field defects. The elevated intraocular pressure was considered the prime factor responsible for the glaucomatous optic neuropathy involving death of retinal ganglion cells and their axons. Extensive investigations into the pathophysiology of glaucoma now reveal the role of multiple factors in the development of retinal ganglion cell death. A better understanding of the pathophysiological mechanisms involved in the onset and progression of glaucomatous optic neuropathy is crucial in the development of better therapeutic options. This review is an effort to summarize the current concepts in the pathophysiology of glaucoma so that newer therapeutic targets can be recognized. The literature available in the National Medical Library and online Pubmed search engine was used for literature review.
authors: Department of Ocular Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, India.
authors: Renu
authors: R
authors: Agarwal
authors: Suresh K
authors: SK
authors: Gupta
authors: Puneet
authors: P
authors: Agarwal
authors: Rohit
authors: R
authors: Saxena
authors: Shyam S
authors: SS
authors: Agrawal
mesh_terms: D017209:Apoptosis; D005123:Eye / Q000098:blood supply; D005901:Glaucoma / Q000150:complications / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D007511:Ischemia / Q000150:complications; D009798:Ocular Hypertension / Q000150:complications; D012165:Retinal Ganglion Cells
chemical_list: D018698:Glutamic Acid