Correlation of cyclooxygenase 2 expression and inflammatory cells infiltration in colorectal cancer.
This study want to determine correlation of cyclooxygenans 2 (Cox-2) expression and inflammatory reaction in colorectal carcinoma. Archival H and E slides of 150 patients with primary colorectal carcinoma were reviewed to confirm pathological feature and to select suitable tissue blocks for immunohistochemical staining with mouse monoclonal antibody against human Cox-2 and various inflammatory cells. After scoring, statistical analysis were carried out with SPSS software, chi2 methods and bivariate pearson correlation analysis. The expression of Cox-2 (grade 3 to 7) in 71.3% of patients associated with mast cells, neutrophils, eosinophils, macrophages, CD3+ lymphocytes infiltration was significant (p = 0.001). Correlation of Cox-2 expression associated with CD8+ lymphocytes infiltration was not significant (p = 0.569). Also CD3+ lymphocytes show severe infiltration when the expression of Cox-2 is negative (p<0.05). The main purpose of this study was to evaluate the interaction between the Cox-2 expression and inflammatory cells infiltration. This study showed that there is a close relationship of Cox-2 expression and mast cells, neutrophils, eosinophils, macrophages and CD3+ lymphocytes. The only exception was CD8+ lymphocytes. It is may be due to independent role of anti tumoral effect of this inflammatory cells.
Naghshvar
F
F
Department of Pathobiology, Mazandaran University of Medical Science, Iran.
Torabizadeh
Zh
Zh
Emadian
O
O
Enami
K
K
Ghahremani
M
M
D000818:Animals; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism
D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human