Promising effect of aromatase inhibitors on recurrent granulosa cell tumors.
Recurring adult-type granulosa cell tumors of the ovary are usually treated by surgical resection followed by chemotherapy or radiation. However, the results of such treatment are disappointing. We describe 4 patients in whom recurrent ovarian granulosa cell tumors were treated with an aromatase inhibitor, with promising results.
Korach
Jacob
J
Department of Gynecologic Oncology, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. jacobkorach@gmail.com
Perri
Tamar
T
Beiner
Mario
M
Davidzon
Tima
T
Fridman
Eddie
E
Ben-Baruch
Gilad
G
D000328:Adult; D000368:Aged; D000077384:Anastrozole; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D005260:Female; D006106:Granulosa Cell Tumor / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D000077289:Letrozole; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D009570:Nitriles / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D011379:Prognosis; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole; D000077289:Letrozole