title: Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction.
abstract: BACKGROUND
  Growth factor-binding proteins influence the growth of infants starting in utero. Adaptation of the fetus to an adverse uterine environment is associated with changes in the growth hormone-growth factor-insulin axis.
  
  
  OBJECTIVE
  To evaluate serum levels of IGF-I and IGFBP-3 in small and appropriate for gestational age newborn infants.
  
  
  METHODS
  Fifty-four newborn infants, small (SGA, n=28) or appropriate (AGA, n=26) for gestational age were matched by gestational age and sex. Blood was collected on the first day of life, and anthropometric measurements were taken at birth. The serum levels of IGF-I and IGFBP-3 were compared, and correlated with the anthropometric measurements.
  
  
  RESULTS
  On the first day of life, mean serum IGFBP-3 levels were significantly lower in SGA babies and correlated with weight, length, head circumference, and ponderal index (weight/length 3) (P<0.0001). In contrast, no associations were found between IGF-I serum levels and these anthropometric measurements.
  
  
  CONCLUSIONS
  Our data show that SGA babies have significantly reduced IGFBP-3 concentrations at birth.
authors: Instituto Fernandes Figueira - Fundação Oswaldo Cruz, Rua Nascimento Silva, 111/502 A, Ipanema - Rio de Janeiro, Rio de Janeiro, Brazil. mdmeio@centroin.com.br
authors: Maria Dalva Barbosa
authors: MD
authors: Baker Méio
authors: Maria Elizabeth
authors: ME
authors: Lopes Moreira
authors: Rosely
authors: R
authors: Sichieri
authors: Aníbal Sanchez
authors: AS
authors: Moura
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D055815:Young Adult
chemical_list: D015415:Biomarkers; C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I