Effect of intracameral triamcinolone acetonide on postoperative intraocular pressure after cataract surgery.
OBJECTIVE
To evaluate the effect of 1 mg intracameral triamcinolone acetonide (TA) on postoperative intraocular pressure (IOP) after routine cataract surgery.


METHODS
This prospective, randomized, placebo-controlled study comprised 120 eyes of 120 patients with uncomplicated cataract surgery. The patients were randomized into two groups. Eyes in group 1 (60 eyes) received an injection of 1 mg TA into the anterior chamber at the end of the surgery, but eyes in group 2 (60 eyes) did not. The biomicroscopic evaluation, visual acuity (VA), and IOP measurements were done at baseline (preoperatively) and 6, 20-24 h, 1 week, and permonthly until 6 months postoperatively.


RESULTS
Mean IOP at 6 and 20-24 h postoperatively were significantly higher than baseline measurements in both groups (P<0.001). Also, the mean IOP values at postoperative 6 and 20-24 h were slightly higher in group 1 than in group 2 (P>0.05 for both). The mean IOPs at week 1 and 1-6 months after surgery were not significantly different from baseline values in both groups (P>0.05 for both time periods). At 6 and 20-24 h postoperatively, the number of eyes with an IOP increase>5 and 10 mm Hg with respect to baseline were not statistically different between the two groups (P>0.05). There were no statistically significant differences in mean VA and the amount of anterior chamber cells and flare between the two groups at any postoperative visit (P>0.05).


CONCLUSIONS
Intracameral injection of 1 mg TA after uncomplicated phacoemulsification surgery had no significant effects on postoperative IOP.
Karalezli
A
A
Department of Ophthalmology, Baskent University School of Medicine, Ankara, Selcuklu, Konya, Turkey. akaralezli@yahoo.com
Borazan
M
M
Kucukerdonmez
C
C
Akman
A
A
Akova
Y A
YA
D000368:Aged; D000867:Anterior Chamber / Q000166:cytology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002386:Cataract / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D056965:Injections, Intraocular; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011446:Prospective Studies; D014065:Tonometry, Ocular; D014222:Triamcinolone Acetonide / Q000494:pharmacology*; D014792:Visual Acuity
D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide