[Aging or tumor: the crosstalk between telomerase and p53].
Telomerase and p53 play critical roles in tumorigenesis and senescence. The mutation of p53 gene and the reactivation of telomerase have been found in most of the human tumors. Aiming telomerase and p53 genes have become important strategies in tumor therapy. We reviewed the aging and tumor phenotype in different status of telomerase and p53 (mTR/p53+/+; mTR/P53/), which indicated that telomere dysfunction could initiate or suppress the tumorigenesis depending on the status of p53. This helps further understanding of the crosstalk between p53 and telomerase in aging and tumorigenesis, and provides a new idea for treating tumor.
Zhang
Xiu-Feng
XF
Lab of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China xiuzheng1203@163.com
Tang
Wen-Ru
WR
Luo
Ying
Y
D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D015197:Carcinogenicity Tests; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D016922:Cellular Senescence / Q000235:genetics; D006801:Humans; D051379:Mice; D009154:Mutation; D009369:Neoplasms / Q000235:genetics; D009687:Nuclear Proteins / Q000378:metabolism; D019098:Telomerase / Q000235:genetics* / Q000502:physiology; D016615:Telomere / Q000201:enzymology / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism / Q000502:physiology
D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53; D019098:Telomerase