title: Plasma levels of 2% lidocaine with 1:100,000 epinephrine with young children undergoing dental procedures.
abstract: Lidocaine levels were determined for 12 children, aged 55 to 150 mo, who received routine dental treatment, including multiple intraoral injections of 2% lidocaine (2.6 to 6.4 mg/kg) with 1:100,000 epinephrine. Peak plasma concentrations of lidocaine ranged from 0.7 to 3.8 mug/ml at 5 to 15 min postinjection. Generally accepted threshold concentrations for the onset of central nervous system toxicity are 5 to 10 mug/ml. In this study, no child approached these levels when given local anesthesia for dental procedures.
authors: R
authors: R
authors: Jurevic
authors: P
authors: P
authors: Milgrom
authors: H W
authors: HW
authors: Karl
authors: P
authors: P
authors: Weinstein
authors: S E
authors: SE
authors: Coldwell
authors: E D
authors: ED
authors: Kharasch
authors: D
authors: D
authors: Mautz
authors: P
authors: P
authors: Domoto