Effect of mometasone furoate on nasal congestion model in rats.
OBJECTIVE
The present study was performed to evaluate the effect of mometasone furoate on a nasal congestion model in Brown Norway rats.


METHODS
Nasal congestion in rats sensitized with toluene-2,4-diisocyanate (TDI) was measured using whole-body plethysmography which allowed animals to move freely.


RESULTS
Penh (enhanced pause), an index of nasal congestion, was significantly increased after 5% TDI challenge in sensitized rats compared with that in non-sensitized rats. The peak of the increase in Penh appeared at 1 and 5 h after TDI challenge. A single topical administration of mometasone furoate (0.05%) at 1 h before TDI challenge suppressed the increase of Penh in sensitized rats. A significant effect was observed 5-6 h after nasal administration. Almost the same results were obtained with fluticasone propionate (0.05%).


CONCLUSIONS
Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.
Ogawa
Masami
M
Preclinical Research Department, Schering-Plough K.K., Osaka, Japan.
Tsumuro
Tae
T
Takubo
Miho
M
Ueda
Yuhki
Y
Yatsuzuka
Rie
R
Kishi
Yuko
Y
Kamei
Chiaki
C
D000287:Administration, Topical; D000730:Androstadienes / Q000494:pharmacology; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D000068298:Fluticasone; D008297:Male; D000068656:Mometasone Furoate; D009297:Nasal Mucosa / Q000187:drug effects / Q000503:physiopathology; D015508:Nasal Obstruction / Q000188:drug therapy*; D010993:Plethysmography, Whole Body; D011244:Pregnadienediols / Q000494:pharmacology*; D051381:Rats; D011914:Rats, Inbred BN; D015656:Respiratory Mechanics / Q000187:drug effects; D013997:Time Factors
D000730:Androstadienes; D018926:Anti-Allergic Agents; D011244:Pregnadienediols; D000068656:Mometasone Furoate; D000068298:Fluticasone