BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers.
BACKGROUND
Epithelial ovarian cancer is one of the most lethal malignancies, and has a high recurrence rate. Thus, prognostic markers for recurrence are crucial for the care of ovarian cancer. As ovarian cancers frequently exhibit chromosome instability, we aimed at assessing the prognostic significance of two key mitotic kinases, BubR1 and Aurora A.


METHODS
We analysed paraffin-embedded tissue sections from 160 ovarian cancer patients whose clinical outcomes had been tracked after first-line treatment.


RESULTS
The median recurrence-free survival in patients with a positive and negative expression of BubR1 was 27 and 83 months, respectively (P<0.001). A positive BubR1 expression was also associated with advanced stage, serous histology and high grade. In contrast, Aurora A immunostaining did not correlate with any of the clinical parameters analysed.


CONCLUSIONS
BubR1, but not Aurora A, is a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers.
Lee
Y-K
YK
Department of Biological Sciences and Research Center for Functional Cellulomics, College of Natural Science, Seoul National University, San 56-1, Shinlim-dong, Gwanak-ku, Seoul 151-742, Republic of Korea.
Choi
E
E
Kim
M A
MA
Park
P-G
PG
Park
N-H
NH
Lee
H
H
D064127:Aurora Kinases; D043171:Chromosomal Instability; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D009375:Neoplasms, Glandular and Epithelial / Q000737:chemistry / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000032:analysis*; D015996:Survival Rate
D064127:Aurora Kinases; C584277:BUB1 protein, human; C090464:Bub1 spindle checkpoint protein; D017346:Protein Serine-Threonine Kinases