Pinostrobin from Boesenbergia pandurata is an inhibitor of Ca2+-signal-mediated cell-cycle regulation in the yeast Saccharomyces cerevisiae.
Upon searching plant extracts for inhibitors of the Ca(2+) signaling pathway using the zds1Delta-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on the Ca(2+) signals involved in the control of G2/M phase cell cycle progression in Saccharomyces cerevisiae.
Wangkangwan
Wachirasak
W
Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Boonkerd
Saipin
S
Chavasiri
Warinthorn
W
Sukapirom
Kasama
K
Pattanapanyasat
Kovit
K
Kongkathip
Ngampong
N
Miyakawa
Tokichi
T
Yompakdee
Chulee
C
D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D005591:Chemical Fractionation; D044950:Flavanones / Q000302:isolation & purification / Q000494:pharmacology*; D016195:G2 Phase / Q000187:drug effects; D009154:Mutation; D010936:Plant Extracts / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D030521:Zingiberaceae / Q000737:chemistry*
D044950:Flavanones; D010936:Plant Extracts; D002118:Calcium; C411294:pinostrobin