Hyperbranched polyamidoamines containing beta-cyclodextrin for controlled release of chlorambucil.
This work is focused on the controlled drug release behavior of hyperbranched HPMA in the presence of beta-CD. Hence, three HPMA-beta-CDs and a pure HPMA were synthesized by Michael addition polymerization. As a model drug, CLB (an anti-cancer drug) was loaded into them via a solution method for in vitro release studies. The DSC results indicate that the CLB/polymer interactions are at the molecular level. Loading CLB into these polymers results in an evident increase in their glass transition temperatures, and DeltaT(g) depends on the beta-CD content. The controlled-release experiments show that the presence of beta-CD can appropriately slow the release of CLB from HPMA-beta-CDs and adjust the ratio of CLB released in total drug loading.
Zhou
Yuanyuan
Y
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Guo
Zhe
Z
Zhang
Yongwen
Y
Huang
Wei
W
Zhou
Yongfeng
Y
Yan
Deyue
D
D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002699:Chlorambucil / Q000737:chemistry / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D011073:Polyamines / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D047392:beta-Cyclodextrins / Q000737:chemistry / Q000378:metabolism
D018906:Antineoplastic Agents, Alkylating; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008689:Methacrylates; D011073:Polyamines; D011108:Polymers; D047392:beta-Cyclodextrins; D002699:Chlorambucil; C031215:betadex; C032802:hydroxypropyl methacrylate