DYRK2 expression may be a predictive marker for chemotherapy in non-small cell lung cancer.
BACKGROUND
The possibility of a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase gene, DYRK2, predicting benefit from chemotherapy for patients with recurrent non-small cell lung cancer (NSCLC) was investigated.


METHODS
Forty patients with recurrent disease after surgery received several combinations of platinum-based chemotherapy. The chemotherapy effectiveness was evaluated according to RECIST (response evaluation criteria in solid tumors). Immunohistochemical (IHC) analysis was used to determine the expression of DYRK2.


RESULTS
Although the response rates between the two groups did not show statistical differences, the disease control rate of the DYRK2-positive group (15 out of 17, 88%) was significantly different from the DYRK2-negative group (8 out of 23, 35%, p=0.001). The median time to the progression (TTP) of disease was significantly different between the two groups (310 days in the positive group, 120 days in the negative, HR=2.12, 95% CI=[1.1-4.09], p=0.024). Multivariate analysis showed that negative DYRK2 expression was a strong predictor of disease progression (HR=3.01, 95% CI=[1.45-6.26], p=0.003).


CONCLUSIONS
Patients with high DYRK2 expression could be good candidates for chemotherapy.
Yamashita
Shin-ichi
S
Department of Surgery II, Faculty of Medicine, Oita University, Yufu, Oita 879-5593, Japan. yamashi1@med.oita-u.ac.jp
Chujo
Masao
M
Moroga
Toshihiko
T
Anami
Kentaro
K
Tokuishi
Keita
K
Miyawaki
Michiyo
M
Kawano
Yozo
Y
Takeno
Shinsuke
S
Yamamoto
Satoshi
S
Kawahara
Katsunobu
K
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017346:Protein Serine-Threonine Kinases / Q000097:blood* / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000097:blood* / Q000235:genetics; D000097603:Dyrk Kinases
D014408:Biomarkers, Tumor; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D000097603:Dyrk Kinases