title: Isolation and structural elucidation of dapoxetine as an adulterant in a health supplement used for sexual performance enhancement.
abstract: A health supplement used for sexual performance enhancement was sent to Health Sciences Authority of Singapore for testing. An unknown compound was detected and isolated and its structure was elucidated using NMR, high-resolution MS, ESI-MS/MS, UV and IR. The compound, dapoxetine, is reported to be a selective serotonin reuptake inhibitor under investigation for the treatment of premature ejaculation.
authors: Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.
authors: Lin
authors: L
authors: Li
authors: Min-Yong
authors: MY
authors: Low
authors: Xiaowei
authors: X
authors: Ge
authors: Bosco C
authors: BC
authors: Bloodworth
authors: Hwee-Ling
authors: HL
authors: Koh
mesh_terms: D001596:Benzylamines / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019587:Dietary Supplements; D004340:Drug Contamination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D009281:Naphthalenes / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013055:Spectrophotometry, Infrared / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods; D013696:Temperature
chemical_list: D001596:Benzylamines; D009281:Naphthalenes; D017367:Selective Serotonin Reuptake Inhibitors; C080598:dapoxetine