The potential role of the angiotensin subtype 2 receptor in cardiovascular protection.
Advances in our knowledge of the renin-angiotensin system have led to better understanding of the mechanisms contributing to the development of cardiovascular, renal, and metabolic disorders. Similarly, the discovery of new components of this system offers opportunities to develop new therapeutic tools to manage these diseases. Angiotensin subtype 2 (AT2) receptor represents one of those components with the potential for improving cardiovascular protection. Current knowledge suggests that the AT2 receptor antagonizes the effects of the angiotensin subtype 1 receptor. AT2 receptor activation is linked to vasodilation, nitric oxide production, and antiproliferative and anti-inflammatory effects. The role of the AT2 receptor in inducing natriuresis, inhibiting renin release, limiting atherosclerosis, and promoting remodeling after myocardial infarction is reviewed in this article.
Siragy
Helmy M
HM
Hypertension Center, University of Virginia, Box 801409, Charlottesville, VA 22908, USA. hms7a@virginia.edu
D000804:Angiotensin II / Q000187:drug effects*; D057912:Angiotensin II Type 2 Receptor Blockers; D001161:Arteriosclerosis / Q000503:physiopathology; D006801:Humans; D006973:Hypertension; D007674:Kidney Diseases / Q000503:physiopathology; D009569:Nitric Oxide / Q000096:biosynthesis; D044140:Receptor, Angiotensin, Type 1 / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects; D000093342:Prorenin Receptor
D057912:Angiotensin II Type 2 Receptor Blockers; D044140:Receptor, Angiotensin, Type 1; D011956:Receptors, Cell Surface; D000804:Angiotensin II; D009569:Nitric Oxide; D000093342:Prorenin Receptor