Facile synthesis of mesoporous SBA-15 silica spheres and its application for high-performance liquid chromatography.
Micrometer-sized mesoporous SBA-15 silica spheres have been synthesized using triblock copolymer poly(ethyleneoxide)-block-poly(propyleneoxide)-block-poly(ethyleneoxide) (EO(20)PO(70)EO(20)) as structure-directing agent with the assistance of 1,3,5-trimethylbenzene and KCl. By controlling the composition of synthesis gel, SBA-15 silica spheres with particle size in the range of 2-4.5 microm could be facilely obtained. The obtained SBA-15 silica spheres were characterized by X-ray diffraction, scanning electron microscopy, and N(2) physisorption technique. Dimethyloctadecylchlorosilane modified mesoporous SBA-15 silica with diameter of 4.5 microm was explored as stationary phase in high-performance liquid chromatography, and its chromatographic characteristics for separation of some small molecules and relatively large bio-molecules have been studied.
Wan
Huihui
H
Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
Liu
Lin
L
Li
Cunman
C
Xue
Xingya
X
Liang
Xinmiao
X
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D014961:X-Ray Diffraction
C116176:PEO-PPO-PEO; D011409:Propylene Glycols; D011092:Polyethylene Glycols; D012822:Silicon Dioxide