Sequential transmission and long-term persistence of an HIV strain partially resistant to protease inhibitors.
Transmission of drug-resistant HIV-1 variants has been increasingly documented. The most commonly observed resistance-associated mutations are thymidine analogue mutations as well as non-nucleoside reverse transcriptase inhibitor mutations. We report on a case of secondary transmission of a protease inhibitor (PI) primary mutation from an infected untreated subject to his sexual partner. Sequences isolated from the 2 patients showed a high level of identity (>99%), both carrying the major IAS PI mutation M46I. The latter mutation persisted in the bloodstream of the female partner 1 year after its first detection.
Polilli
Ennio
E
Clinical Pathology Unit, "Spirito Santo" Hospital, Pescara, Italy.
Di Masi
Francesco
F
Sozio
Federica
F
Mazzotta
Elena
E
Alterio
Luciana
L
Cosentino
Luana
L
Clerico
Luigi
L
Perno
Carlo Federico
CF
Parruti
Giustino
G
D000328:Adult; D019943:Amino Acid Substitution; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D015658:HIV Infections / Q000503:physiopathology / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D008297:Male; D011480:Protease Inhibitors / Q000494:pharmacology*; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012383:Romania; D014766:Viremia
D011480:Protease Inhibitors; D012367:RNA, Viral