title: Nicotine-induced osteonecrosis. A case report.
abstract: This paper describes a previously unpublished side-effect of nicotine replacement chewing gum and presents useful information about the effects of nicotine on the oral environment. It is important to consider this when diagnosing an area of ulceration.
  
  
  CONCLUSIONS
  Patients who use nicotine chewing gum should be advised that prolonged contact with the alveolar mucosa should be avoided. They should be told that regular chewing helps dispersal of the nicotine.
authors: Newcastle Dental Hospital, Richardson Road, Newcastle Upon Tyne NE2 4BW, UK.
authors: Yi Kwan
authors: YK
authors: Loo
mesh_terms: D002638:Chewing Gum / Q000009:adverse effects; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000139:chemically induced*; D008875:Middle Aged; D009538:Nicotine / Q000009:adverse effects*; D010020:Osteonecrosis / Q000139:chemically induced*; D016540:Smoking Cessation / Q000379:methods
chemical_list: D002638:Chewing Gum; D009538:Nicotine