title: Intra-arterial thrombolysis in basilar artery occlusions combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitors in basilar artery thrombosis.
abstract: Basilar artery thrombosis has high morbidity and mortality. Though intra-arterial thrombolytics have proven efficacy in the treatment of acute basilar artery occlusion, the elevation of procoagulant factors in the blood after intra-arterial thrombolysis could result in subsequent thrombus formation and clinical deterioration. Glycoprotein IIb/IIIa inhibitors have been shown to reduce this elevation in procoagulants. We present a pilot study of three cases of acute basilar artery occlusion treated with a combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitor with remarkable clinical recovery seen in all the patients.
authors: Department of Neuroradiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India. sgaikwad_63@yahoo.com
authors: S B
authors: SB
authors: Gaikwad
authors: M V
authors: MV
authors: Padma
authors: E J
authors: EJ
authors: Moses
authors: Kanika
authors: K
authors: Sethi
authors: M
authors: M
authors: Tripathi
authors: R
authors: R
authors: Bhatia
authors: K
authors: K
authors: Prasad
authors: N K
authors: NK
authors: Mishra
mesh_terms: D000328:Adult; D001488:Basilar Artery / Q000000981:diagnostic imaging; D002533:Cerebral Angiography / Q000379:methods; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D020767:Intracranial Thrombosis / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D010959:Tissue Plasminogen Activator