title: [Study on the tumor infiltration in mesorectum of rectal cancer by spiral computed tomography and histopathology].
abstract: OBJECTIVE
  To evaluate the value of spiral computed tomography in the preoperative assessment of the degree of tumor infiltration in mesorectum and circumferential resection margin status of rectal cancer compared with large tissue slice technique.
  
  
  METHODS
  Fifty-seven patients with rectal cancer diagnosed by fiber colonoscopy and pathology from March 2007 to December 2007 underwent preoperative 64-layers spiral CT examination. The degree of tumor infiltration in mesorectum and circumferential resection margin status were evaluated. Large tissue slice technique was applied in the pathologic study after the total mesorectal excision of the rectum to determine the degree of tumor infiltration in mesorectum and the circumferential resection margin status. The spiral CT findings were compared with pathologic results. The accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the CT results were assessed respectively.
  
  
  RESULTS
  The overall spiral CT accuracy was 93.0% (53/57) for the degree of tumor infiltration in mesorectum, and it was 94.7%, 94.7% and 96.5% for degree I, II, III infiltration, respectively. Fifty-three cases (93.0%) were accurately predicated with the circumferential resection margin status. The sensitivity, specificity, PPV and NPV of spiral CT measurement was 80.0%, 97.6%, 92.3% and 93.2%, respectively, and was consistent well with the histopathological diagnosis.
  
  
  CONCLUSIONS
  Spiral CT provides accurate preoperative assessment for the degree of tumor infiltration in mesorectum and circumferential resection margin status of rectal cancer.
authors: Department of General Surgery, Qingdao University Medical School Hospital, Qingdao 266003, China.
authors: Hong-qing
authors: HQ
authors: Zhuo
authors: Yan-bing
authors: YB
authors: Zhou
authors: Liang
authors: L
authors: Lü
authors: Jian
authors: J
authors: Zhou
authors: Wen-yi
authors: WY
authors: Yang
authors: Yu-jun
authors: YJ
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008643:Mesentery / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000000981:diagnostic imaging; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D012007:Rectum / Q000000981:diagnostic imaging / Q000473:pathology*; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed