title: Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis.
abstract: During the development and progression of severe acute pancreatitis (SAP), conspicuous immune dysregulation develops, which is mainly manifested as excessive immune response in the early stage and immunosuppression in the late stage. This process involves complex changes in a variety of immune molecules and cells, such as cytokines, complements, lymphocytes, and leukocytes. With the gradual deepening of studies on the development and progression of SAP, the role of immune dysregulation in the pathogenesis of SAP has attracted more and more attention. In this article, we review the advances in research on the immune dysregulation in SAP and the immunotherapy of this disease through exploring the formation of excessive immune response and immune suppression as well as their mutual transformation.
authors: Department of General Surgery, Hangzhou First People's Hospital, Hangzhou 310006, China. zxp99688@vip.163.com
authors: Xi-Ping
authors: XP
authors: Zhang
authors: Han-Qing
authors: HQ
authors: Chen
authors: Fang
authors: F
authors: Liu
authors: Jie
authors: J
authors: Zhang
mesh_terms: D000208:Acute Disease; D000818:Animals; D035843:Biomedical Research / Q000639:trends*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D018448:Models, Immunological; D010195:Pancreatitis / Q000276:immunology* / Q000628:therapy*
chemical_list: D016207:Cytokines