Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa.
T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in autoimmunity is well documented, there is growing evidence that the Th17 lineage and other interleukin (IL)-17-producing cells are critical for host defense against bacterial, fungal, and viral infections at mucosal surfaces. Here we summarize recent progress in our understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa.
Khader
S A
SA
Department of Pediatrics (Pulmonology) and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gaffen
S L
SL
Kolls
J K
JK
D000818:Animals; D019070:Cell Lineage; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D007167:Immunotherapy; D007239:Infections / Q000276:immunology*; D007378:Interleukins / Q000378:metabolism; D008211:Lymphocyte Cooperation / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D009092:Mucous Membrane / Q000276:immunology*; D053722:Receptors, Interleukin-17 / Q000172:deficiency / Q000502:physiology; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
C109985:IL17RA protein, human; C491673:Il17ra protein, mouse; D007378:Interleukins; D053722:Receptors, Interleukin-17; D014409:Tumor Necrosis Factor-alpha