2-Arylbenzothiazole as a privileged scaffold in drug discovery.
Substituted 2-arylbenzothiazoles have emerged in recent years as an important pharmacophore in a number of diagnostic and therapeutic settings. Attractive features of drug candidates based on this benzothiazole scaffold include their synthetic accessibility, and synthetic approaches to 2-arylbenzothiazole-based compounds will be reviewed here. Examples of 2-arylbenzothiazoles endowed with diagnostic/therapeutic activity include the 2-(4-aminophenyl)benzothiazole series, which has a remarkable activity profile in both the potential non-invasive diagnosis of Alzheimer's disease and as antitumour agents.
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Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, Wales, UK.
Westwell
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D000544:Alzheimer Disease / Q000175:diagnosis; D000682:Amyloid / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D052160:Benzothiazoles / Q000737:chemistry* / Q000494:pharmacology; D003287:Contrast Media / Q000737:chemistry; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
D000682:Amyloid; D000970:Antineoplastic Agents; D052160:Benzothiazoles; D003287:Contrast Media