title: Therapeutic management of allergic diseases.
abstract: Allergic diseases are characterized by the activation of inflammatory cells and by a massive release of mediators. The aim of this chapter was to describe succinctly the modes of action, indications, and side effects of the major antiallergic and antiasthmatic drugs. When considering the ideal pharmacokinetic characteristics of a drug, a poorly metabolized drug may confer a lower variability in plasma concentrations and metabolism-based drug interactions, although poorly metabolized drugs may be prone to transporter-based disposition and interactions. The ideal pharmacological properties of a drug include high binding affinity, high selectivity, and appropriate association and dissociation rates. Finally, from a patient perspective, the frequency and route of administration are important considerations for ease of use.
authors: Department of Otohinolaryngology, Head and Neck Surgery, Ghent University Hospital, Ghent University, Belgium. jeanbaptiste.watelet@ugent.be
authors: Jean-Baptiste
authors: JB
authors: Watelet
authors: Michel
authors: M
authors: Gillard
authors: Margherita Strolin
authors: MS
authors: Benedetti
authors: Bénédicte
authors: B
authors: Lelièvre
authors: Bertrand
authors: B
authors: Diquet
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D015195:Drug Design; D004347:Drug Interactions; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D015394:Molecular Structure; D017060:Patient Satisfaction
chemical_list: D018926:Anti-Allergic Agents; D018927:Anti-Asthmatic Agents