Prevaccination genomic diversity of human papillomavirus genotype 6 (HPV 6).
Prevaccination genomic diversity of human papillomavirus genotype 6 (HPV 6) was established by sequencing 3798 bp of 77 clinically important HPV 6 isolates obtained from 45 and 32 patients with genital warts and laryngeal papillomas, respectively. By analyzing pooled L1, LCR, E6, E2, and E5 nucleotide data of an individual isolate, a total of 36 different genomic variants were identified, of which six (12 isolates), one (one isolate) and 29 (64 isolates) corresponded to HPV 6b, HPV 6a, and HPV 6vc genetic lineages, respectively. Several novel, potentially important mutations were identified. Non-prototypic HPV 6vc genomic variants were found in the majority of genital warts and laryngeal papillomas included in the study. The presence of serious HPV 6 genome sequence errors was confirmed and novel sequence errors were identified in sequence repositories.
Kocjan
Bostjan J
BJ
Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1105 Ljubljana, Slovenia.
Poljak
Mario
M
Cimerman
Mojca
M
Gale
Nina
N
Potocnik
Marko
M
Bogovac
Zeljka
Z
Seme
Katja
K
D001483:Base Sequence; D016000:Cluster Analysis; D003218:Condylomata Acuminata / Q000821:virology; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D005838:Genotype; D052163:Human papillomavirus 6 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007822:Laryngeal Neoplasms / Q000821:virology; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D010212:Papilloma / Q000821:virology; D030361:Papillomavirus Infections / Q000821:virology*; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
D004279:DNA, Viral