Inhibition of neutral endopeptidase 24.11 does not potentiate the improvement in glycemic control obtained with dipeptidyl peptidase-4 inhibition in diabetic Goto-Kakizaki rats.
Simonsen
L
L
University of Copenhagen, Department of Biomedical Sciences, Panum Institute, Copenhagen, Denmark.
Pilgaard
S
S
Carr
R D
RD
Kanstrup
A B
AB
Holst
J J
JJ
Deacon
C F
CF
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000201:enzymology* / Q000378:metabolism; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D054873:Dipeptidyl-Peptidase IV Inhibitors; D004195:Disease Models, Animal; D015536:Down-Regulation; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007189:Indans / Q000008:administration & dosage; D008297:Male; D015260:Neprilysin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011422:Propionates / Q000008:administration & dosage; D011897:Random Allocation; D051381:Rats; D014970:Xanthines / Q000008:administration & dosage
D001786:Blood Glucose; D018819:Dipeptidyl Peptidase 4; D054873:Dipeptidyl-Peptidase IV Inhibitors; D004791:Enzyme Inhibitors; D006442:Glycated Hemoglobin; D007189:Indans; D015260:Neprilysin; D011422:Propionates; D014970:Xanthines; C522532:NN 7201; C517652:hemoglobin A1c protein, human; C062766:candoxatril; C545245:Dpp4 protein, mouse