title: Cerebellar Hypoperfusion during Transient Global Amnesia: An MRI and Oculographic Study.
abstract: OBJECTIVE
  Transient global amnesia (TGA) is characterized by sudden anterograde and retrograde amnesia lasting for up to 24 hours. Diffusion-weighted magnetic resonance imaging (DWI) in cases of TGA and ischemia demonstrates a high frequency of high signal intensities restricted to the hippocampus, and this has been proposed as an etiology of TGA. The aims of this study were to characterize the DWI and single-photon-emission computed tomography (SPECT) findings during the acute and recovered phases of TGA and to correlate the findings with oculomotor abnormalities.
  
  
  METHODS
  Five consecutive patients with a clinical diagnosis of TGA underwent DWI and SPECT of the brain within 24 hours after symptom onset and again 3 days later. Eye movements were also recorded using three-dimensional video-oculography.
  
  
  RESULTS
  In all patients, DWI disclosed small punctuate (1-3 mm), high-signal lesions in the lateral portion of the hippocampus. The initial SPECT also revealed hypoperfusion in the cerebellar vermis, which had recovered by the follow-up examination. Three patients showed saccadic hypermetria or impaired smooth pursuit only during the acute phase.
  
  
  CONCLUSIONS
  Our patients with TGA showed cerebellar vermian hypoperfusion in addition to ischemic insults to the lateral hippocampus. The oculomotor abnormalities observed in our patients support the occurrence of cerebellar dysfunction during the TGA attack.
authors: Department of Neurology, Hyoja Geriatric Hospital, Yongin, Korea.
authors: Youngsoon
authors: Y
authors: Yang
authors: Ji Soo
authors: JS
authors: Kim
authors: Sangyun
authors: S
authors: Kim
authors: Yu Kyeong
authors: YK
authors: Kim
authors: Yong Tae
authors: YT
authors: Kwak
authors: Il-Woo
authors: IW
authors: Han