title: CT043, a protective antigen that induces a CD4+ Th1 response during Chlamydia trachomatis infection in mice and humans.
abstract: Despite several decades of intensive studies, no vaccines against Chlamydia trachomatis, an intracellular pathogen causing serious ocular and urogenital diseases, are available yet. Infection-induced immunity in both animal models and humans strongly supports the notion that for a vaccine to be effective a strong CD4(+) Th1 immune response should be induced. In the course of our vaccine screening program based on the selection of chlamydial proteins eliciting cell-mediated immunity, we have found that CT043, a protein annotated as hypothetical, induces CD4(+) Th1 cells both in chlamydia-infected mice and in human patients with diagnosed C. trachomatis genital infection. DNA priming/protein boost immunization with CT043 results in a 2.6-log inclusion-forming unit reduction in the murine lung infection model. Sequence analysis of CT043 from C. trachomatis human isolates belonging to the most representative genital serovars revealed a high degree of conservation, suggesting that this antigen could provide cross-serotype protection. Therefore, CT043 is a promising vaccine candidate against C. trachomatis infection.
authors: Novartis Vaccines and Diagnostics, 53100 Siena, Italy.
authors: Eva
authors: E
authors: Meoni
authors: Elisa
authors: E
authors: Faenzi
authors: Elisabetta
authors: E
authors: Frigimelica
authors: Luisanna
authors: L
authors: Zedda
authors: David
authors: D
authors: Skibinski
authors: Serena
authors: S
authors: Giovinazzi
authors: Alessandra
authors: A
authors: Bonci
authors: Roberto
authors: R
authors: Petracca
authors: Erika
authors: E
authors: Bartolini
authors: Giuliano
authors: G
authors: Galli
authors: Mauro
authors: M
authors: Agnusdei
authors: Filomena
authors: F
authors: Nardelli
authors: Francesca
authors: F
authors: Buricchi
authors: Nathalie
authors: N
authors: Norais
authors: Ilaria
authors: I
authors: Ferlenghi
authors: Manuela
authors: M
authors: Donati
authors: Roberto
authors: R
authors: Cevenini
authors: Oretta
authors: O
authors: Finco
authors: Guido
authors: G
authors: Grandi
authors: Renata
authors: R
authors: Grifantini
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology; D002690:Chlamydia Infections / Q000276:immunology*; D023502:Chlamydia muridarum / Q000276:immunology; D002692:Chlamydia trachomatis / Q000276:immunology*; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology; D006801:Humans; D007114:Immunization; D007371:Interferon-gamma / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D018272:Porins / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D018272:Porins; C071677:omp1 protein, Chlamydia trachomatis; D007371:Interferon-gamma