Hydrophobic modification of sodium alginate and its application in drug controlled release.
Sodium alginate was hydrophobically modified by coupling of polybutyl methacrylate onto the alginate. The polybutyl methacrylate was previously prepared through polymerization of butyl methacrylate in the presence of 2-amino-ethanethiol as a chain transfer agent. The structure of the product was characterized by Fourier-transformed infrared spectrometry, nuclear magnetic resonance ((1)HNMR) and thermogravimetry. The result of fluorescence analysis showed that the hydrophobicity of the modified alginate was obviously increased. The modified alginate conjugate was used for immobilization of bovine serum albumin in the presence of calcium chloride. In addition, the release behavior of the drug-loaded alginate in deionized water and Tris-HCl buffer solution (pH 7.2) was investigated. It was found that the modified sodium alginate possessed prolonged release behavior compared to unmodified sodium alginate, and it had potential application in controlled release as a drug carrier.
Yao
Bolong
B
Jiangnan University, Wuxi, China.
Ni
Caihua
C
Xiong
Cheng
C
Zhu
Changping
C
Huang
Bo
B
D000464:Alginates / Q000737:chemistry; D000818:Animals; D057005:Bioengineering; D002417:Cattle; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008863:Microspheres; D011109:Polymethacrylic Acids / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000008:administration & dosage; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry
D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D011109:Polymethacrylic Acids; D012710:Serum Albumin, Bovine; D020723:Glucuronic Acid; C068872:polybutyl methacrylate