title: Cooling of the nucleus raphe dorsalis induces sleep in the cat.
abstract: Localized moderate cooling (+10 degrees C) of the anterior and ventral part of the raphe dorsalis induced cortical synchronization and ponto-geniculo-occipital (PGO) waves followed sometimes by paradoxical sleep. Cooling the region of the raphe magnus produced cortical arousal. After depletion of brain 5-hydroxytryptamine (5-HT) by para-chlorophenylalanine, cooling the raphe dorsalis resulted in muscle atonia and bursts of high frequency PGO waves but not in cortical synchronization. Following restoration of brain 5-HT by intravenous administration of 5-hydroxytryptophan, cooling again produced cortical synchronization and PGO waves as in the control experiments, but with a diminishing efficacy during repetitive cooling episodes.
authors: Department of Experimental Medicine, University Claude Bernard, 8, Avenue Rockefeller, 69373 Lyon Cedex 2 France.
authors: R
authors: R
authors: Cespuglio
authors: E
authors: E
authors: Walker
authors: M E
authors: ME
authors: Gomez
authors: R
authors: R
authors: Musolino