title: [Lymphangiomyomatosis pathologically diagnosed by surgery for pneumothorax].
abstract: We report a case of incipient pulmonary lymphangioleiomyomatosis (LAM) diagnosed by histopathological examination of excised lung. A 28-year-old woman was referred to our hospital because of recurrent left pneumothorax. Computed tomography showed no abnormality except for small bullae in the right middle lobe. She underwent video-assisted thoracoscopic surgery and we excised the apex of the left lung showing hypertrophic pleura. Microscopic examinations of the surgical specimen revealed multiple focal accumulations of small spindle-shaped cells stained positively with anti-HMB-45 antibody, specific for LAM. Furthermore, among these multiple lesions, vascular invasion of HMB-45 positive cells were observed, which demonstrates invasive and metastatic potential of LAM cells as previously reported. This case implicates a need for a careful pathological examination of excised specimens in female cases of surgically treated pneumothorax even though pre-operation or macroscopic examination shows no specific findings.
authors: Department of Thoracic Surgery, Tohoku Koseinenkin Hospital, Sendai, Japan.
authors: T
authors: T
authors: Suzuki
authors: T
authors: T
authors: Tabata
authors: K
authors: K
authors: Inoue
authors: N
authors: N
authors: Fujikawa
authors: S
authors: S
authors: Fujimura
authors: K
authors: K
authors: Murakami
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D018192:Lymphangioleiomyomatosis / Q000473:pathology*; D011030:Pneumothorax / Q000601:surgery*; D020775:Thoracic Surgery, Video-Assisted