title: Syndecan-1 and tenascin expression in cystic tumors of the pancreas.
abstract: BACKGROUND
  Since benign and malignant mucin-producing tumors of the pancreas may be difficult to distinguish from each other; preoperative methods for differential diagnosis would reduce unnecessary surgery.
  
  
  OBJECTIVE
  To compare syndecan-1 and tenascin immunoexpression in benign and malignant cystic pancreatic tumors.
  
  
  METHODS
  We used immunohistochemical staining for syndecan-1 and tenascin antibodies in tumor tissue samples.
  
  
  METHODS
  Helsinki University Central Hospital.
  
  
  METHODS
  Tissue material came from 33 patients undergoing surgery from 1979 to 2005 for cystic pancreatic tumors.
  
  
  RESULTS
  A statistically significant difference appeared in syndecan-1 expression between benign (mucinous cystic neoplasms and intraductal papillary mucinous neoplasms) and mucinous carcinomas, but there was no significant difference in tenascin immunoexpression between these tumor groups.
  
  
  CONCLUSIONS
  Our findings suggest that low syndecan-1 expression might serve as a predictive factor for malignancy in cystic tumors of the pancreas.
authors: Department of General Surgery, Helsinki University Central Hospital, Helsinki, Finland.
authors: Leena
authors: L
authors: Kylänpää
authors: Jaana
authors: J
authors: Hagström
authors: Anna
authors: A
authors: Lepistö
authors: Tiina
authors: T
authors: Linjama
authors: Päivi
authors: P
authors: Kärkkäinen
authors: Tuula
authors: T
authors: Kiviluoto
authors: Caj
authors: C
authors: Haglund
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010181:Pancreatic Cyst / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D011237:Predictive Value of Tests; D053668:Syndecan-1 / Q000096:biosynthesis*; D019063:Tenascin / Q000096:biosynthesis*
chemical_list: D053668:Syndecan-1; D019063:Tenascin