title: Prevalence of apoptotic epidermal keratinocytes in eosinophilic dermatoses of the cat: a retrospective light-microscopic study of 145 skin-biopsy specimens.
abstract: A retrospective light-microscopic study was performed on skin-biopsy specimens from 145 cats with eosinophilic inflammatory dermatoses in order to determine the prevalence of apoptotic epidermal keratinocytes (AKs), the prevalence of eosinophils in close proximity to AKs, and whether there was a difference in the prevalence of AKs or the prevalence of eosinophils in close proximity to AKs based on histopathological reaction pattern. Overall, 62/145 (43%) specimens had AKs. Of the cases in which AKs were seen, 18% had eosinophils in close proximity to the AKs. The specimens were divided into three groups based on histopathological reaction pattern: perivascular-to-interstitial, diffuse, and nodular. No difference in the prevalence of AKs was found among the three histological groups. Because the sample size containing eosinophils in close proximity to AKs was too small to compare the three histological patterns individually, nodular and non-nodular patterns were compared. No difference in the presence of eosinophils in close proximity to AKs was found in these two subsets. More AKs were present if eosinophils were in close proximity to the AKs (range 1-9 with eosinophils near compared to 0-7 without).
authors: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors: Joya S
authors: JS
authors: Griffin
authors: Danny W
authors: DW
authors: Scott
authors: Hollis N
authors: HN
authors: Erb
mesh_terms: D000818:Animals; D017209:Apoptosis; D001706:Biopsy / Q000662:veterinary; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D004804:Eosinophils / Q000166:cytology / Q000473:pathology*; D005260:Female; D015603:Keratinocytes / Q000166:cytology / Q000473:pathology*; D008297:Male; D015995:Prevalence; D012867:Skin / Q000166:cytology / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology / Q000662:veterinary*