Dermatologic manifestations of HPV in HIV-infected individuals.
Dermatologic human papillomavirus (HPV) infection in HIV patients manifests as both anogenital and nongenital skin disease. Anogenital HPV-related disease includes benign condyloma acuminata, the most common cutaneous manifestation of genital HPV infection; intermediate malignancy or premalignant conditions including giant condyloma acuminata (also called Buschke-Loewenstein tumor), anal intraepithelial neoplasia, penile intraepithelial neoplasia, and vaginal or vulvar intraepithelial neoplasia; and frankly malignant disease including Bowen's disease and invasive anal, penile, or vulvar carcinoma. Cutaneous HPV-related disease in nongenital skin is also increased in HIV-positive patients, in the form of benign common warts, epidermodysplasia verruciformis-like skin lesions, and nonmelanoma skin cancers. This review and update addresses the above listed dermatologic manifestations of HPV disease in HIV-infected individuals, with an emphasis on new findings and published data from 2006 to 2008.
Gormley
Rachel H
RH
University of Pennsylvania, Department of Dermatology, Philadelphia, PA 19104, USA.
Kovarik
Carrie L
CL
D023241:Antiretroviral Therapy, Highly Active; D002278:Carcinoma in Situ / Q000209:etiology / Q000503:physiopathology; D015658:HIV Infections / Q000150:complications* / Q000628:therapy; D006801:Humans; D030361:Papillomavirus Infections / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D053918:Papillomavirus Vaccines / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects / Q000503:physiopathology*; D012878:Skin Neoplasms / Q000209:etiology / Q000503:physiopathology
D053918:Papillomavirus Vaccines