Effects of sevoflurane on postoperative liver functions in morbidly obese as compared to the non-obese patients.
OBJECTIVE
To assess the effect of sevoflurane anesthesia on hepatic function in morbidly obese versus non-obese patients undergoing abdominal surgeries.


METHODS
We prospectively evaluated the levels of the serum concentration of liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), and total bilirubin (TBil), in 42 morbidly obese and 40 non obese patients who were scheduled for elective abdominal surgery under sevoflurane anesthesia at the Jordan University Hospital, Amman, Jordan. Measurement of liver enzymes was done in the recovery room, and on the first, 3 and 7 days after sevoflurane anesthesia, and the results were compared between the morbidly obese and non obese patients.


RESULTS
ALT, AST, GGT and LDH increased significantly in the morbidly obese than they did in non obese patients. In morbidly obese patients TBil increased gradually peaking 7 days after anesthesia, LDH increased in the recovery room, AST and ALT increased in the recovery room and first day, while GGT increased 7th day after anesthesia. In non obese patients, AST, LDH increased in the recovery. ALP did not change in both groups.


CONCLUSIONS
Sevoflurane induces elevation of the serum liver enzymes in morbidly obese patients with variable onsets.
Al-Ghanem
Subhi M
SM
Dept. of Anesthesia & Intensive Care, Faculty of Medicine, Univ. of Jordan, Amman, Jordan. alghanem@ju.edu.jo
Massad
Islam M
IM
Al-Barazangi
Bassam
B
Al-Mustafa
Mahmoud
M
Daoud
Fayez S
FS
Abu-Ali
Hamdi
H
D000005:Abdomen / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D018685:Anesthetics, Inhalation / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications*; D011183:Postoperative Complications / Q000139:chemically induced; D011446:Prospective Studies; D000077149:Sevoflurane; D013997:Time Factors; D055815:Young Adult
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane