title: Role of CT in detecting malignancy during follow-up of patients with branch-type IPMN of the pancreas.
abstract: OBJECTIVE
  This retrospective study evaluated the suitability of computed tomography (CT) to detect malignancy while following patients with branch-type IPMN, most of which are benign and may be treated with observation alone.
  
  
  METHODS
  Forty-two surgical specimens resected from patients with a diagnosis of branch-type IPMN were pathologically classified as benign (n=26), which included hyperplasia and adenoma, or malignant (n=16), including moderate dysplasia or adenocarcinoma. It was compared the differences in the sizes of the tumor and main pancreatic duct (MPD) and the presence of mural nodules on CT between the groups.
  
  
  RESULTS
  In the malignant group, it was observed a larger tumor size (47.8 vs. 23.8 mm; p = 0.001) and increased dilation of the MPD (9.3 vs. 5.0 mm; p = 0.001) than those seen in the benign group. The accuracy of CT diagnosis of mural nodules, however, was only 62%. Tumor diameter > or =40 mm or MPD diameter >10 mm predicted malignancy with a sensitivity and negative predictive value of 93.8% and 95.7%, respectively.
  
  
  CONCLUSIONS
  Either tumor size or MPD dilation detected by CT could predict the majority of malignant branch-type IPMNs. Increases in these morphological characteristics on CT images during the follow-up period would be an accurate method to predict a diagnosis of malignancy.
authors: Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. satto@med.hokudai.ac.jp
authors: Satoshi
authors: S
authors: Hirano
authors: Satoshi
authors: S
authors: Kondo
authors: Eiichi
authors: E
authors: Tanaka
authors: Toshiaki
authors: T
authors: Shichinohe
authors: On
authors: O
authors: Suzuki
authors: Michio
authors: M
authors: Shimizu
authors: Tomoo
authors: T
authors: Itoh
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging* / Q000473:pathology; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000000981:diagnostic imaging* / Q000473:pathology; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*