title: Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms.
abstract: BACKGROUND
  The long-term outcomes of endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell neoplasms (ESCNs) have not been evaluated to date.
  
  
  OBJECTIVE
  Assess the long-term outcomes of ESD for ESCNs from our consecutive cases.
  
  
  METHODS
  Retrospective study from a single institution.
  
  
  METHODS
  From January 2002 to July 2008, 107 superficial ESCNs in 84 patients were treated by ESD. The enrolled patients were divided into 2 groups based on the lesion with the deepest invasion in each patient: group A, intraepithelial neoplasm or invasive carcinoma limited to the lamina propria mucosa and group B, invasive carcinoma deeper than the lamina propria mucosa.
  
  
  METHODS
  Rates of en bloc resection, complete resection, and complication were evaluated as short-term outcomes. Overall survival, cause-specific survival, and postoperative stricture rates were evaluated as long-term outcomes.
  
  
  RESULTS
  The rates of en bloc resection and complete resection were 100% and 88%, respectively. Perforation accompanied by mediastinal emphysema was observed in 4 (4%) patients. No patient experienced massive bleeding. During the median observation of 632 days (range 8-2358), 15 (18%) patients experienced benign esophageal stricture with dysphagia, which was successfully managed by balloon dilation for a median of 2 sessions (range 1-20). One patient had local recurrence 6 months after ESD. In 2 patients with intramucosal invasive carcinomas in the muscularis mucosa, distant metastases were observed 9 and 18 months after ESD. During the observation period, 3 patients died of esophageal carcinoma. The 5-year cause-specific survival rates of groups A and B were 100% and 85%, respectively.
  
  
  CONCLUSIONS
  This was a retrospective study with a relatively short follow-up and a small number of patients from a single institution.
  
  
  CONCLUSIONS
  This long-term follow-up study revealed that ESD is a potentially curative treatment for superficial ESCNs. There were substantial risks of perforation and stricture that were successfully managed endoscopically.
authors: Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: Satoshi
authors: S
authors: Ono
authors: Mitsuhiro
authors: M
authors: Fujishiro
authors: Keiko
authors: K
authors: Niimi
authors: Osamu
authors: O
authors: Goto
authors: Shinya
authors: S
authors: Kodashima
authors: Nobutake
authors: N
authors: Yamamichi
authors: Masao
authors: M
authors: Omata
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D004210:Dissection / Q000379:methods*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007413:Intestinal Mucosa / Q000473:pathology / Q000601:surgery*; D007564:Japan / Q000453:epidemiology; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome