Complete atrioventricular block associated with dapsone therapy: a rare complication of dapsone-induced hypersensitivity syndrome.
Dapsone is still widely used for a range of infectious and inflammatory diseases. A potential severe side-effect, known as dapsone-induced hypersensitivity syndrome (DHS), may occur. DHS is characterized by fever, skin rashes, lymphadenopathy and multiorgan dysfunction manifesting as hepatitis, cholangitis, pneumonitis, colitis, thyroiditis and myocarditis. However, DHS-associated complete atrioventricular block has not previously been reported. We describe here a 45-year-old Chinese woman who developed DHS after 5 weeks of dapsone therapy for pustular palmoplantar psoriasis. In addition to typical DHS symptoms, she experienced several episodes of syncope as a result of complete atrioventricular block which was successfully reversed with a permanent pacemaker implantation.
Zhu
K J
KJ
Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China.
He
F T
FT
Jin
N
N
Lou
J X
JX
Cheng
H
H
D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use; D054537:Atrioventricular Block / Q000139:chemically induced* / Q000628:therapy; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011565:Psoriasis / Q000188:drug therapy; D013575:Syncope / Q000139:chemically induced
D000890:Anti-Infective Agents; D003622:Dapsone