title: In vitro biological activity of Salvia leriifolia benth essential oil relevant to the treatment of Alzheimer's disease.
abstract: In this study the chemical composition, cholinesterase inhibitory property and anti-inflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and alpha-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC(50) 2.26 microL/mL. Interesting cholinesterase inhibitory activity was also found with IC(50) values of 0.32 and 0.29 microL/mL for acetylcholinesterase (AChE) and butyrrylcholinesterase (BChE), respectively. Moreover, this oil inhibited LPS-induced NO production with an IC(50) value of 165 microg/mL. The absence of cytotoxicity at 1000 microg/mL was evaluated by MTT assay in 142BR cells.
authors: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Italy. mr.loizzo@unical.it
authors: Monica Rosa
authors: MR
authors: Loizzo
authors: Federica
authors: F
authors: Menichini
authors: Rosa
authors: R
authors: Tundis
authors: Marco
authors: M
authors: Bonesi
authors: Filomena
authors: F
authors: Conforti
authors: Farsad
authors: F
authors: Nadjafi
authors: Giancarlo Antonio
authors: GA
authors: Statti
authors: Natale Giuseppe
authors: NG
authors: Frega
authors: Francesco
authors: F
authors: Menichini
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002091:Butyrylcholinesterase / Q000378:metabolism; D002460:Cell Line; D002849:Chromatography, Gas; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D027544:Salvia / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D008070:Lipopolysaccharides; D009822:Oils, Volatile; D009569:Nitric Oxide; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase