title: Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis.
abstract: Bis-dicarba analogues of native dicystine-containing alpha-conotoxin Rg1A, an analgesic peptide isolated from cone snail venom, were constructed on resin using a regioselective metathesis-hydrogenation strategy.
authors: School of Chemistry, Centre for Green Chemistry, Monash University, Clayton 3800, Victoria, Australia. andrea.robinson@sci.monash.edu.au
authors: Andrea J
authors: AJ
authors: Robinson
authors: Bianca J
authors: BJ
authors: van Lierop
authors: Rebecca D
authors: RD
authors: Garland
authors: Euneace
authors: E
authors: Teoh
authors: Jomana
authors: J
authors: Elaridi
authors: Jayamini P
authors: JP
authors: Illesinghe
authors: W Roy
authors: WR
authors: Jackson
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D010456:Peptides, Cyclic / Q000737:chemistry*; D014118:Toxins, Biological / Q000737:chemistry*
chemical_list: D000475:Alkenes; D010456:Peptides, Cyclic; D014118:Toxins, Biological