title: Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats.
abstract: Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS. Hepatic expression of ATP-binding cassette transporter G5 (ABCG5) and ATP-binding cassette transporter G8 (ABCG8) mRNA was significantly higher in rats fed SPI and HMF than in those fed CAS. These observations suggest that increased biliary excretion of cholesterol in SPI and HMF groups is caused by the enhanced expression of Abcg5/Abcg8.
authors: Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan. iikeda@biochem.tohoku.ac.jp
authors: Ikuo
authors: I
authors: Ikeda
authors: Mariko
authors: M
authors: Kudo
authors: Tadateru
authors: T
authors: Hamada
authors: Koji
authors: K
authors: Nagao
authors: Yoko
authors: Y
authors: Oshiro
authors: Masaki
authors: M
authors: Kato
authors: Takashi
authors: T
authors: Sugawara
authors: Takashi
authors: T
authors: Yamahira
authors: Hiroko
authors: H
authors: Ito
authors: Shogo
authors: S
authors: Tamaru
authors: Masao
authors: M
authors: Sato
authors: Katsumi
authors: K
authors: Imaizumi
authors: Satoshi
authors: S
authors: Nagaoka
authors: Teruyoshi
authors: T
authors: Yanagita
mesh_terms: D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D000071019:ATP Binding Cassette Transporter, Subfamily G, Member 8; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000818:Animals; D001646:Bile / Q000378:metabolism*; D002784:Cholesterol / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004063:Digestion; D008074:Lipoproteins / Q000235:genetics*; D008099:Liver / Q000737:chemistry; D008297:Male; D008970:Molecular Weight; D010447:Peptide Hydrolases / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins / Q000008:administration & dosage* / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D000071019:ATP Binding Cassette Transporter, Subfamily G, Member 8; D018528:ATP-Binding Cassette Transporters; C480692:Abcg5 protein, rat; C480693:Abcg8 protein, rat; D004044:Dietary Proteins; D008074:Lipoproteins; D012333:RNA, Messenger; D030262:Soybean Proteins; D002784:Cholesterol; D010447:Peptide Hydrolases