title: Phylogenetic analysis and characterization of Korean bovine viral diarrhea viruses.
abstract: Thirty-six bovine viral disease viruses (BVDVs) were identified in bovine feces (n=16), brains (n=2), and aborted fetuses (n=18) in Korea. To reveal the genetic diversity and characteristics of these Korean strains, the sequences of their 5'-untranslated regions (5'-UTRs) were determined and then compared with published reference sequences. Neighbor-joining phylogenetic analysis revealed that most of the Korean viruses were of the BVDV subtypes 1a (n=17) or 2a (n=17). The remaining strains were of subtypes 1b (n=1) and 1n (n=1). This analysis indicates that the 1a and 2a BVDV subtypes are predominant and widespread in Korea. In addition, the prevalence of BVDV-2 was markedly higher in aborted fetuses than in other samples and was more often associated with reproductive problems and significant mortality in cattle.
authors: Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service, Gyeonggi-do, 430-824, Republic of Korea. jku0622@nvrqs.go.kr
authors: Jae-Ku
authors: JK
authors: Oem
authors: Bang-Hun
authors: BH
authors: Hyun
authors: Sang-Ho
authors: SH
authors: Cha
authors: Kyoung-Ki
authors: KK
authors: Lee
authors: Seong-Hee
authors: SH
authors: Kim
authors: Hye-Ryoung
authors: HR
authors: Kim
authors: Choi-Kyu
authors: CK
authors: Park
authors: Yi-Seok
authors: YS
authors: Joo
mesh_terms: D020121:5' Untranslated Regions; D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D002417:Cattle; D004279:DNA, Viral / Q000235:genetics; D030241:Diarrhea Virus 1, Bovine Viral / Q000145:classification*; D030242:Diarrhea Virus 2, Bovine Viral / Q000145:classification* / Q000235:genetics; D014644:Genetic Variation; D007723:Korea / Q000453:epidemiology; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary
chemical_list: D020121:5' Untranslated Regions; D004279:DNA, Viral