Deep brain stimulation for the treatment of epilepsy.
During the last decade, deep brain stimulation (DBS) has been used to treat several neurologic disorders, including epilepsy. Promising results have been reported with stimulation in different brain regions. At present however, several issues remain unanswered. As an example, it is still unclear whether particular seizure types and syndromes should be treated with DBS in different targets or with different stimulation parameters. In addition, clinical, electrophysiological and anatomical features capable of predicting a good postoperative outcome are still unknown. We review the published literature on DBS, cortical and cerebellar stimulation for the treatment of epilepsy focusing predominantly on the rationale and clinical outcome in each target.
Hamani
Clement
C
Division of Neurosurgery Toronto Western Hospital - University of Toronto, Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada. chamani@uhnres.utoronto.ca
Andrade
Danielle
D
Hodaie
Mojgan
M
Wennberg
Richard
R
Lozano
Andres
A
D001921:Brain / Q000033:anatomy & histology / Q000503:physiopathology*; D002531:Cerebellum / Q000033:anatomy & histology / Q000502:physiology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology; D046690:Deep Brain Stimulation / Q000009:adverse effects / Q000379:methods* / Q000639:trends; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000503:physiopathology / Q000628:therapy*; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D013788:Thalamus / Q000033:anatomy & histology / Q000502:physiology; D016896:Treatment Outcome