Random versus directionally persistent cell migration.
Directional migration is an important component of cell motility. Although the basic mechanisms of random cell movement are well characterized, no single model explains the complex regulation of directional migration. Multiple factors operate at each step of cell migration to stabilize lamellipodia and maintain directional migration. Factors such as the topography of the extracellular matrix, the cellular polarity machinery, receptor signalling, integrin trafficking, integrin co-receptors and actomyosin contraction converge on regulation of the Rho family of GTPases and the control of lamellipodial protrusions to promote directional migration.
Petrie
Ryan J
RJ
Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA. e-mails: myriam.hemberger@bbsrc.ac.uk
Doyle
Andrew D
AD
Yamada
Kenneth M
KM
D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D022081:Cell Surface Extensions / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D021381:Protein Transport