title: Structural and viscoelastic properties of actin/filamin networks: cross-linked versus bundled networks.
abstract: The high diversity of cytoskeletal actin structures is accomplished by myriads of actin binding proteins (ABPs). Depending on its concentration, even a single type of ABP can induce different actin microstructures. Thus, for an overall understanding of the cytoskeleton, a detailed characterization of the cross-linker's effect on structural and mechanical properties of actin networks is required for each ABP. Using confocal microscopy and macrorheology, we investigate both cross-linked and bundled actin/filamin networks and compare their microstructures as well as their viscoelastic properties in the linear and the nonlinear regime.
authors: Lehrstuhl für Zellbiophysik E27, Technische Universität München, Garching, Germany.
authors: K M
authors: KM
authors: Schmoller
authors: O
authors: O
authors: Lieleg
authors: A R
authors: AR
authors: Bausch
mesh_terms: D000199:Actins / Q000737:chemistry*; D000818:Animals; D002645:Chickens; D003285:Contractile Proteins / Q000737:chemistry*; D003599:Cytoskeleton / Q000737:chemistry*; D055119:Elastic Modulus; D004548:Elasticity; D064448:Filamins; D008840:Microfilament Proteins / Q000737:chemistry*; D018613:Microscopy, Confocal; D011336:Probability; D020836:Protein Structure, Quaternary; D011817:Rabbits; D014783:Viscosity
chemical_list: D000199:Actins; D003285:Contractile Proteins; D064448:Filamins; D008840:Microfilament Proteins