[Clinicopathological study of 5 cases of proximal-type epithelioid sarcoma].
OBJECTIVE
To investigate the clinicopathological characteristics, diagnosis and differential diagnoses of proximal-type epithelioid sarcoma (PES).


METHODS
Five cases of PES were retrieved from pathology files. Clinical, pathologic and immunohistochemical features of the tumors were reviewed.


RESULTS
One patient was female and 4 were male. Ages of the patients ranged from 19 to 46 years. The sites of the tumor involvement were vulvar (2 cases), hypogastric zone (1 case), anterosuperior iliac spine (1 case) and buttock (1 case). Clinically, the tumor masses were painless and progressive solitary nodules. Microscopically, the tumor cell growth was infiltrative in nature, nodular in appearance with degenerative and necrotic cells at the central areas. The tumors consisted of relatively uniform epithelioid cells with round or oval nuclei and eosinophilic cytoplasm. Immunohistochemically, the tumor cells were positive for vimentin (5/5), CK (4/5), EMA (4/5), beta-catenin (3/5), CD34 (3/5), and S-100 protein (1/5), but were negative for SMA, MyoD1, Desmin, HMB-45, CK7 and CK20.


CONCLUSIONS
Definitive diagnosis of PES relies on its histopathological characteristics in conjunction with appropriate immunohistochemical findings.
Wang
Chun-nian
CN
Department of Pathology, Medical School of Nanjing University/Nanjing General Hospital of PLA, Nanjing 210002, China.
An
Xiao-jing
XJ
Shi
Qun-li
QL
Xu
Yan
Y
Zhou
Xiao-jun
XJ
Li
Nan-yun
NY
Zhou
Hang-bo
HB
Ma
Heng-hui
HH
D000328:Adult; D017024:Chemotherapy, Adjuvant; D015622:Epithelioid Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D009364:Neoplasm Recurrence, Local; D010386:Pelvic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000378:metabolism*; D014846:Vulvar Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D055815:Young Adult; D051176:beta Catenin / Q000378:metabolism
D018396:Mucin-1; D014746:Vimentin; D051176:beta Catenin