Mismatch DNA-specific enzymatic cleavage employed in a new method for the electrochemical detection of genetic mutations.
Utilizing enzymatic mismatched DNA-specific cleavage and electrocatalytic signaling, a new electrochemical method for the detection of DNA mutations was developed and successfully applied to detect various mutations in the BRCA1 gene.
Won
Byoung Yeon
BY
Department of Chemical and Biomolecular Engineering, KAIST, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea.
Shin
Sung Chul
SC
Chung
Won-young
WY
Shin
Sujeong
S
Cho
Dae-Yeon
DY
Park
Hyun Gyu
HG
D020137:Base Pair Mismatch; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D004563:Electrochemistry / Q000379:methods*; D019398:Genes, BRCA1; D006801:Humans; D009154:Mutation
D004247:DNA