title: Bioactive diterpene derivatives from the marine sponge Spongionella sp.
abstract: Three new compounds of the rare classes trisnorditerpenes, bisnorditerpenes, and norditerpenes, gracilins J-L (1, 2, 6), and a new diterpene, 3'-norspongiolactone (8), were isolated from the extract of the marine sponge Spongionella sp. using NMR- and bioassay-guided fractionation, in addition to three known gracilins (3-5) as well as the known diterpenoid tetrahydroaplysulphurin-1 (7). The structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The structure of gracilin H (3) was confirmed by single-crystal X-ray analysis. All compounds were tested for their cytotoxicity and for their potential to inhibit EGF-R tyrosine kinase.
authors: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB243UE, Scotland, UK.
authors: Mostafa E
authors: ME
authors: Rateb
authors: Wael E
authors: WE
authors: Houssen
authors: Marc
authors: M
authors: Schumacher
authors: William T A
authors: WT
authors: Harrison
authors: Marc
authors: M
authors: Diederich
authors: Rainer
authors: R
authors: Ebel
authors: Marcel
authors: M
authors: Jaspars
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D008386:Marine Biology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*
chemical_list: C544221:3'-norspongiolactone; D000970:Antineoplastic Agents; D004224:Diterpenes; C544218:gracilin J; C544219:gracilin K; C544220:gracilin L; D011505:Protein-Tyrosine Kinases