Expression patterns of miR-96, miR-182 and miR-183 in the development inner ear.
MicroRNAs (miRNAs) constitute a class of small non-coding endogenous RNAs that downregulate gene expression by binding to 3' untranslated region (UTR) of target messenger RNAs. Although they have been found to regulate developmental and physiological processes in several organs and tissues, their role in the regulation of the inner ear transcriptome remains unknown. In this report, we have performed systematic in situ hybridization to analyze the temporal and spatial distribution of three miRNAs (miR-96, mR-182, and mR-183) that are likely to arise from a single precursor RNA during the development and the maturation of the cochlea. Strikingly we found that the expression of mR-96, mR-182 and mR-183 was highly dynamic during the development of the cochlea, from the patterning to the differentiation of the main cochlear structures.
Sacheli
Rosalie
R
Nguyen
Laurent
L
Borgs
Laurence
L
Vandenbosch
Renaud
R
Bodson
Morgan
M
Lefebvre
Philippe
P
Malgrange
Brigitte
B
D000818:Animals; D000831:Animals, Newborn; D003051:Cochlea / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D007758:Ear, Inner / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism
D035683:MicroRNAs; C540524:Mirn182 microRNA, mouse; C543802:Mirn183 microRNA, mouse; C541554:Mirn96 microRNA, mouse