title: Syntheses and biological evaluations of carbosilane dendrimers uniformly functionalized with sialyl alpha(2-->3) lactose moieties as inhibitors for human influenza viruses.
abstract: A series of carbosilane dendrimers uniformly functionalized with sialyl lactose moieties (Neu5Ac alpha2-->3Gal beta1-->4Glc) was systematically synthesized, and biological evaluations for anti-influenza virus activity using the glycodendrimers were performed. The results suggested that the glycodendrimers had unique biological activities depending on the form of their core frame, and Dumbbell(1)6-amide type glycodendrimer 7 showed particularly strong inhibitory activities against human influenza viruses [A/PR/8/34 (H1N1) and A/Aichi/2/68 (H3N2)]. The results suggested that the structure-activity relationship (SAR) on the glycolibrary against various influenza viruses was observed, and dumbbell-shaped dendrimers as supporting carbohydrate moieties were found to be the most suitable core scaffolds in this study.
authors: Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan.
authors: Hiroyuki
authors: H
authors: Oka
authors: Tomotsune
authors: T
authors: Onaga
authors: Tetsuo
authors: T
authors: Koyama
authors: Chao-Tan
authors: CT
authors: Guo
authors: Yasuo
authors: Y
authors: Suzuki
authors: Yasuaki
authors: Y
authors: Esumi
authors: Ken
authors: K
authors: Hatano
authors: Daiyo
authors: D
authors: Terunuma
authors: Koji
authors: K
authors: Matsuoka
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004285:Dogs; D004912:Erythrocytes / Q000166:cytology / Q000821:virology; D006384:Hemagglutination / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects / Q000472:pathogenicity; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects / Q000472:pathogenicity; D009980:Influenza A virus / Q000187:drug effects* / Q000472:pathogenicity; D007251:Influenza, Human / Q000188:drug therapy; D007668:Kidney / Q000166:cytology / Q000821:virology; D007785:Lactose / Q000737:chemistry; D015394:Molecular Structure; D019158:N-Acetylneuraminic Acid / Q000737:chemistry; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D050091:Dendrimers; D012821:Silanes; C504072:carbosilane; D019158:N-Acetylneuraminic Acid; D007785:Lactose