Antibacterial activity of Hylomecon hylomeconoides against methicillin-resistant Staphylococcus aureus.
Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH(2)Cl(2), EtOAc, and H(2)O) were investigated against MRSA. The most active extract (CH(2)Cl(2)) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 microg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 microg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.
Choi
Jang-Gi
JG
College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Jeonbuk, 570-749, Republic of Korea.
Kang
Ok-Hwa
OH
Chae
Hee-Sung
HS
Obiang-Obounou
Brice
B
Lee
Young-Seob
YS
Oh
You-Chang
YC
Kim
Min-San
MS
Shin
Dong-Won
DW
Kim
Jeong-Ah
JA
Kim
Young-Ho
YH
Kwon
Dong-Yeul
DY
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics; D053119:Benzophenanthridines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D028101:Papaveraceae / Q000737:chemistry*; D046915:Penicillin-Binding Proteins; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy
C438021:6-methoxydihydrosanguinarine; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D053119:Benzophenanthridines; D007546:Isoquinolines; D046915:Penicillin-Binding Proteins; D010936:Plant Extracts; C487789:mecA protein, Staphylococcus aureus