Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults.
BACKGROUND
Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-HT2A receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin 5HT2A receptor (5HT2AR) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT2AR availability in subjects greater than 60 years old.


METHODS
Six healthy subjects (age range = 65-78 years) completed two [18F]-setoperone PET scans on two separate occasions 5-16 weeks apart.


RESULTS
The average difference in the binding potential (BPND) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions.


CONCLUSIONS
We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other 5HT2AR radiotracers in younger subject samples.
Chow
Tiffany W
TW
The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada. tchow@rotman-baycrest.on.ca
Mamo
David C
DC
Uchida
Hiroyuki
H
Graff-Guerrero
Ariel
A
Houle
Sylvain
S
Smith
Gwenn S
GS
Pollock
Bruce G
BG
Mulsant
Benoit H
BH
D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D011744:Pyrimidinones / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D011985:Receptors, Serotonin / Q000378:metabolism*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
D011744:Pyrimidinones; D019275:Radiopharmaceuticals; D011985:Receptors, Serotonin; C078730:serotonin 5 receptor; C045359:setoperone