The role of caveolin-1 in prostate cancer: clinical implications.
Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer.
Thompson
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TC
Department of Genitourinary Medical Oncology-Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. timthomp@mdanderson.org
Tahir
S A
SA
Li
L
L
Watanabe
M
M
Naruishi
K
K
Yang
G
G
Kadmon
D
D
Logothetis
C J
CJ
Troncoso
P
P
Ren
C
C
Goltsov
A
A
Park
S
S
D014408:Biomarkers, Tumor; D051242:Caveolin 1 / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D015854:Up-Regulation
D014408:Biomarkers, Tumor; C495540:CAV1 protein, human; D051242:Caveolin 1