Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs.
Antitumor B (ATB) is a Chinese herbal mixture of six plants. Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal and lung cancers. We have recently developed a new mouse model for lung squamous cell carcinomas (SCC). In this study, lung SCC mouse model was characterized using small-animal imaging techniques (magnetic resonance imaging and computed tomography). ATB decreased lung SCC significantly (3.1-fold; P < 0.05) and increased lung hyperplastic lesions by 2.4-fold (P < 0.05). This observation suggests that ATB can block hyperplasia from progression to SCC. ATB tissue distribution was determined using matrine as a marker chemical. We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs.
Wang
Yian
Y
Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zhang
Zhongqiu
Z
Garbow
Joel R
JR
Rowland
Doug J
DJ
Lubet
Ronald A
RA
Sit
Daniel
D
Law
Francis
F
You
Ming
M
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D001681:Biological Assay; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000517:prevention & control*; D018890:Chemoprevention; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000517:prevention & control*; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D055114:X-Ray Microtomography / Q000379:methods
D016588:Anticarcinogenic Agents; C027128:Antitumor B; D004365:Drugs, Chinese Herbal