Nondestructive, colorimetric monitoring of amines and thiols on a solid support.
A new, nondestructive, highly sensitive method for colorimetric monitoring of primary amines, secondary amines, and thiols on a solid support was developed. The resin used in this method is simply regenerated for the repetition of the reaction or an ensuing reaction. By using this new method, several peptides containing secondary amide linkages and C-terminal hydrazide groups were prepared in high purities and yields.
Yang
Seh-Jin
SJ
Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
Tian
Xi Zhe
XZ
Shin
Injae
I
D000577:Amides / Q000737:chemistry; D000588:Amines / Q000032:analysis* / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry; D003124:Colorimetry / Q000379:methods*; D007202:Indicators and Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D009025:Morpholines / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012117:Resins, Synthetic / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000032:analysis* / Q000737:chemistry
D000577:Amides; D000588:Amines; D001391:Azo Compounds; D007202:Indicators and Reagents; D009025:Morpholines; D010455:Peptides; D012117:Resins, Synthetic; D013438:Sulfhydryl Compounds; C069318:Disperse Red 1; C058866:N-ethylmorpholine