title: Pyridinium ylide-assisted one-pot two-step tandem synthesis of polysubstituted cyclopropanes.
abstract: A sequential one-pot two-step tandem reaction for efficient synthesis of polysubstituted cyclopropanes has been developed. The three-component reaction of alpha-halogenated methylene compounds, aromatic aldehydes, and acetonitrile derivatives produced first the intermediates pyridinium salts and electron-deficient olefins, followed by cyclopropanation of pyridinium ylide with electron-deficient olefins in situ to afford polysubstituted cyclopropanes. Target compounds were obtained in high yields and were diastereomerically pure after recrystallization.
authors: College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors: Qi-Fang
authors: QF
authors: Wang
authors: Xiao-Kai
authors: XK
authors: Song
authors: Jiao
authors: J
authors: Chen
authors: Chao-Guo
authors: CG
authors: Yan
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D018360:Crystallography, X-Ray; D003500:Cyclization; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D003521:Cyclopropanes; D011726:Pyridinium Compounds