Microchip electrophoresis in low-temperature co-fired ceramics technology with contactless conductivity measurement.
In this paper a novel micromachined contactless conductivity CE device produced in low temperature co-fired ceramics (LTCC) is introduced. The application of LTCC multilayer technology provides a promising method for the contactless detection of conductive compounds because of its increased dielectric constant compared with glass or plastics. The capacitive coupling of the excitation signal into the microchannel across the LTCC substrate is improved, resulting in better detection sensitivity. Two silver electrodes located externally at opposite sides at the end of the separation channel act as detector. Impedance variations in the channel are measured without galvanic contact between electrodes and fluid. Inorganic ions are separated in less than 1 min with this novel ceramic device. The limit of detection is 10 microM for potassium.
Fercher
Georg
G
Vienna University of Technology, Institute of Sensor and Actuator Systems, Vienna, Austria. georg.fercher@tuwien.ac.at
Smetana
Walter
W
Vellekoop
Michiel J
MJ
D002516:Ceramics / Q000737:chemistry*; D003080:Cold Temperature; D004566:Electrodes; D046209:Electrophoresis, Microchip / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D016014:Linear Models; D008094:Lithium / Q000032:analysis; D011188:Potassium / Q000032:analysis; D012680:Sensitivity and Specificity; D012964:Sodium / Q000032:analysis
D008094:Lithium; D012964:Sodium; D011188:Potassium