title: Is there a correspondence between half-lives of motor endplate acetylcholinesterase and junctional acetylcholine receptors?
abstract: In order to study the turnover rate of motor endplate acetylcholinesterase (AChE), we have treated hypoglassal nerve with 10 mM colchine, a drug that produced a reversible decrease of AChE from geniohyoid muscle endplates. The return of AChE to the normal steady-state level has been used to calculate an AChE half-life of 4.6 days. This value is very close to that obtained for the half-life of junctional acetylcholine receptors (AChR). Our result supports the contention that both macromolecules have the same turnover rate.
authors: Department of Cell Biology and Laboratory of Neurophysiology, Catholic University of Chile, Santiago Chile.
authors: N C
authors: NC
authors: Inestrosa
authors: H L
authors: HL
authors: Fernández