Formin-binding proteins: modulators of formin-dependent actin polymerization.
Formins represent a major branch of actin nucleators along with the Arp2/3 complex, Spire and Cordon-bleu. Formin-mediated actin nucleation requires the formin homology 2 domain and, although the nucleation per se does not require additional factors, formin-binding proteins have been shown to be essential for the regulation of formin-dependent actin assembly in vivo. This regulation could be accomplished by formin-binding proteins being directly involved in formin-driven actin nucleation, by formin-binding proteins influencing the activated state of the formins, by linking formin-driven actin polymerization to Arp2/3 driven actin polymerization, or by influencing the subcellular localization of the formins. This review article will focus on mammalian formin-binding proteins and their roles during vital cellular processes, such as cell migration, cell division and intracellular trafficking.
Aspenström
Pontus
P
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Box 280, Nobels väg 16, SE-171 77 Stockholm, Sweden. pontus.aspenstrom@ki.se
D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism; D000199:Actins / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D016764:Cell Polarity; D050556:Fatty Acid-Binding Proteins; D005326:Fetal Proteins / Q000235:genetics / Q000378:metabolism*; D000080865:Formins; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D051304:Profilins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D019061:src-Family Kinases / Q000378:metabolism
D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins; D005326:Fetal Proteins; C106410:Fnbp1 protein, mouse; D000080865:Formins; D008840:Microfilament Proteins; D009687:Nuclear Proteins; D051304:Profilins; D019061:src-Family Kinases