Does glomerular hyperfiltration in pregnancy damage the kidney in women with more parities?
OBJECTIVE
We aimed to investigate the glomerular hyperfiltration due to pregnancy in women with more parities.


METHODS
Five hundred women aged 52.57 +/- 8.08 years, without a history of hypertension, diabetes mellitus or complicated pregnancy were involved in the study. They were divided into three groups. Group 1: women with no or one parity (n = 76); group 2: women with two or three parities (n = 333); group 3: women with four or more parities (n = 91). Laboratory parameters and demographical data were compared between the three groups.


RESULTS
Mean age, serum urea and serum creatinine were similar between three groups. Patients in group 3 had significantly higher GFR values compared to groups 1 and 2 (109.44 +/- 30.99, 110.76 +/- 30.22 and 121.92 +/- 34.73 mL/min/1.73 m(2) for groups 1, 2 and 3, respectively; P = 0.008 for group 1 vs group 3; P = 0.002 for group 2 vs group 3).


CONCLUSIONS
In our study, we suggest that glomerular hyperfiltration due to pregnancy does not have adverse effects on kidney in women with more parities. Pregnancy may have possible protective mechanisms for kidney against adverse effects of glomerular hyperfiltration.
Gumus
Ilknur Inegol
II
Department of Obstetrics and Gynecology, Fatih University School of Medicine, Ankara, Turkey.
Uz
Ebru
E
Bavbek
Nuket
N
Kargili
Ayse
A
Yanik
Burcu
B
Turgut
Faruk Hilmi
FH
Akcay
Ali
A
Turhan
Nilgun Ozturk
NO
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015992:Body Mass Index; D015331:Cohort Studies; D016001:Confidence Intervals; D003404:Creatinine / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D007677:Kidney Function Tests; D008875:Middle Aged; D010298:Parity; D011247:Pregnancy / Q000502:physiology*; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000453:epidemiology*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014508:Urea / Q000652:urine; D014527:Uric Acid / Q000652:urine; D016482:Urinalysis
D014527:Uric Acid; D014508:Urea; D003404:Creatinine