title: Radiation therapy for HIV-associated diffuse large cell non-Hodgkin lymphoma.
abstract: OBJECTIVE
  To report the clinical experience with external beam radiotherapy (RT) for AIDS-related lymphoma (ARL) with or without the involvement of the central nervous system (CNS) in HIV-infected patients.
  
  
  METHODS
  Clinical outcome of 24 HIV-seropositive patients with ARL treated with RT from 1995 to 2004 was reviewed, testing factors associated with outcome.
  
  
  RESULTS
  After 1 and 5 years, the overall survival was 65% and 35%, respectively. The mean RT dose was 31 Gy after normalization to fractions of daily 2 Gy (range, 7.8-47.2 Gy). Radiotherapy dose was associated with survival in univariate (P = .04) and multivariate analysis (P = .01). Other factors in univariate analysis associated with outcome were viral load (VL), highly active antiretroviral therapy (HAART), ARL stage, and CNS involvement. Patients with CNS involvement achieved complete response in 46% and improved clinical performance was seen in 73%.
  
  
  CONCLUSIONS
  After chemotherapy, RT in combination with HAART is highly active, and RT should be encouraged especially after suboptimal responses to induction treatment.
authors: Radiation Oncology, Zurich University Hospital, University of Zurich, Zurich, Switzerland. sacha.rothschild@dkf.unibe.ch
authors: Sacha
authors: S
authors: Rothschild
authors: Mathias
authors: M
authors: Dolder
authors: Burkhardt
authors: B
authors: Seifert
authors: Urs M
authors: UM
authors: Lütolf
authors: I Frank
authors: IF
authors: Ciernik
mesh_terms: D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D016543:Central Nervous System Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy; D017024:Chemotherapy, Adjuvant; D005260:Female; D006679:HIV Seropositivity; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D016019:Survival Analysis; D019562:Viral Load