cis-Clerodane diterpenoids from the liverwort Gottschelia schizopleura and their cytotoxic activity.
Two new and three previously known CIS-clerodane diterpenoids were isolated from the wild liverwort Gottschelia schizopleura (Jungermanniales, Jungermanniaceae). Their structures were established on the basis of spectroscopic analysis, especially 1D and 2D NMR data. The cytotoxic activities of compounds 1- 5 were evaluated against liver hepatoblastoma (HEP-G2), lung carcinoma (A549), breast ductal carcinoma (MDA-MB-435), and colon adenocarcinoma (LOVO) cell lines. Compound 1 showed moderate inhibition against MDA-MB-435 and LOVO cells.
Liu
Chun-Mei
CM
Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
Zhu
Rui-Liang
RL
Liu
Run-Hui
RH
Li
Hui-Liang
HL
Shan
Lei
L
Xu
Xi-Ke
XK
Zhang
Wei-Dong
WD
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D045785:Diterpenes, Clerodane / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045785:Diterpenes, Clerodane; D010936:Plant Extracts