Pd(0)/PR3-catalyzed intermolecular arylation of sp3 C-H bonds.
Pd(0)-catalyzed intermolecular arylation of sp(3) C-H bonds has been achieved using PR(3)/ArI. This protocol can be used to arylate a variety of aliphatic carboxylic acid derivatives, including a number of bioactive drug molecules. The use of fluorinated aryl iodides also allows for the introduction of fluorine into a molecule of interest.
Wasa
Masayuki
M
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Engle
Keary M
KM
Yu
Jin-Quan
JQ
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000577:Amides; D008024:Ligands; D009942:Organometallic Compounds; D010165:Palladium