Local degradation of luteinizing hormone-releasing hormone (LH-RH) in the rat central nervous system.
Peptidases inactivating luteinizing hormone-releasing hormone (LH-RH) were found to be present in two subcellular fractions prepared from the following areas of the central nervous system of male and female rats: thalamus, hypothalamus, cortex and cerebellum. LH-RH immunoreactivity was also detected in these fractions after peptidase activity had been removed by heat denaturation. These findings support the concept that LH-RH may have a role in modulating neuronal activity within the central nervous system (CNS).
Griffiths
E C
EC
Department of Physiology, Stopford Building, University of Manchester, Manchester M13 9PT, Great Britain.
Forbes
R
R
Jeffcoate
S L
SL
Holland
D T
DT