Food-dependent Cushing's syndrome.
It has recently been proposed that other hormones than ACTH can control cortisol production in Cushing's syndrome with bilateral adrenal hyperplasia. We present a case of food-dependent Cushing's syndrome. After a positive response of cortisol production during mixed meals, several tests identified glucose-dependent insulinotropic polypeptide (GIP) as the driving hormone responsible for the cortisol overproduction. Identification of aberrant hormone receptor expression is of importance because it may create a possibility for pharmacological treatment.
Messidoro
C
C
Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, the Netherlands.
Elte
J W F
JW
Castro Cabezas
M
M
van Agteren
M
M
Lacroix
A
A
de Herder
W W
WW
D000311:Adrenal Glands / Q000473:pathology*; D003480:Cushing Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism*; D005260:Female; D005502:Food / Q000009:adverse effects*; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism*; D005765:Gastrointestinal Agents / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D006965:Hyperplasia; D008875:Middle Aged; D015282:Octreotide / Q000008:administration & dosage; D016896:Treatment Outcome
D005765:Gastrointestinal Agents; D005749:Gastric Inhibitory Polypeptide; D015282:Octreotide; D006854:Hydrocortisone