title: Evaluation of scleral buckling for stage 4A retinopathy of prematurity by fluorescein angiography.
abstract: OBJECTIVE
  To determine the early efficacy of scleral buckling for active neovascularization by fundus fluorescein angiography (FA) in eyes with stage 4A retinopathy of prematurity.
  
  
  METHODS
  A retrospective, nonrandomized, observational case series.
  
  
  METHODS
  Patients who underwent scleral buckling for stage 4A ROP at the National Center for Child Health and Development, Tokyo, Japan, from October 2007 through November 2008 were included. Preoperative and postoperative FA and fundus photographs obtained with a wide-field digital pediatric imaging system were reviewed. Three patients (5 eyes; gestational ages at birth, 23 to 25 weeks; birth weights, 574 to 811 g) with zone II stage 4A ROP who underwent postoperative FA, 2 weeks or less after scleral buckling (range, 7 to 12 days; postmenstrual ages at postoperative FA, 41 to 45 weeks) were evaluated. Patients who underwent postoperative FA 2 weeks or more after scleral buckling were excluded.
  
  
  RESULTS
  Despite fluorescein leakage from fibrovascular tissue in all eyes before surgery, markedly decreased leakage occurred only between 7 to 12 days after surgery. The retinas were reattached completely in all eyes after surgery.
  
  
  CONCLUSIONS
  Scleral buckling may prevent progression of retinal detachment in stage 4A ROP by reducing the tractional force and stabilizing the neovascular activity of the fibrovascular tissue.
authors: Department of Ophthalmology, National Center for Child Health and Development, Tokyo, Japan.
authors: Tae
authors: T
authors: Yokoi
authors: Tadashi
authors: T
authors: Yokoi
authors: Yuri
authors: Y
authors: Kobayashi
authors: Miina
authors: M
authors: Hiraoka
authors: Sachiko
authors: S
authors: Nishina
authors: Noriyuki
authors: N
authors: Azuma
mesh_terms: D002199:Capillary Permeability; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D005865:Gestational Age; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D015861:Retinal Neovascularization / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D012171:Retinal Vessels / Q000473:pathology; D012178:Retinopathy of Prematurity / Q000145:classification / Q000175:diagnosis* / Q000601:surgery*; D012189:Retrospective Studies; D012591:Scleral Buckling; D016896:Treatment Outcome