title: Childhood stroke in a child with familial Mediterranean fever carrying several prothrombotic risk factors.
abstract: Familial Mediterranean fever (FMF) was recently associated with a hypercoagulable state. However, clinically overt thrombosis remains a rare event limited to patients with other predisposing factors. We herein present a child with FMF who experienced a stroke. An extensive thrombophilia work-up revealed multiple inherited and acquired risk factors. In areas with high prevalence of prothrombotic mutations and in children who are products of consanguineous marriages, early screening for concurrent thrombotic risk factors is warranted; as this may help design an optimal management plan and prevent unfavourable outcomes.
authors: Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors: E G
authors: EG
authors: Aoun
authors: K M
authors: KM
authors: Musallam
authors: I
authors: I
authors: Uthman
authors: A
authors: A
authors: Beydoun
authors: T
authors: T
authors: El-Hajj
authors: Ali T
authors: AT
authors: Taher
mesh_terms: D000293:Adolescent; D003241:Consanguinity; D005165:Factor V / Q000235:genetics; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000235:genetics*; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D009154:Mutation / Q000235:genetics; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D042965:Methylenetetrahydrofolate Reductase (NADPH2)