title: The use of tripeptides for lead discovery of 5-HT4 receptor ligands.
abstract: A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further synthetic work.
authors: Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Vic. 3052, Australia.
authors: A
authors: A
authors: Hanna-Elias
authors: P E
authors: PE
authors: Thompson
authors: D T
authors: DT
authors: Manallack
authors: H R
authors: HR
authors: Irving
authors: I M
authors: IM
authors: Coupar
authors: I
authors: I
authors: Berque-Bestel
authors: M N
authors: MN
authors: Iskander
mesh_terms: D000595:Amino Acid Sequence; D001679:Biogenic Amines / Q000378:metabolism; D055808:Drug Discovery; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism*; D044422:Receptors, Serotonin, 5-HT4 / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001679:Biogenic Amines; D008024:Ligands; D009842:Oligopeptides; D044422:Receptors, Serotonin, 5-HT4