The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease.
The serotonin 6 receptor is attracting attention as an etiological contributor in cognition deficits in diseases such as Alzheimer's disease, anxiety/depression and schizophrenia. In this review, we discuss the role of this recently discovered G protein-coupled receptor in cognition and memory, particularly in Alzheimer's disease. A surge in publications that describe the development of ligands for this receptor have recently come to light, underscoring the emerging interest in this receptor as a drug target. We also explore the current status of structure-activity relationship studies that have focused on the design of novel antagonists for the serotonin 6 receptor.
Geldenhuys
Werner J
WJ
Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, OH 44272, USA. wgeldenh@neoucom.edu
Van der Schyf
Cornelis J
CJ
D000544:Alzheimer Disease / Q000150:complications*; D000818:Animals; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology*; D015195:Drug Design; D006801:Humans; D008954:Models, Biological; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C097216:serotonin 6 receptor