title: A case-control study of single-pass albumin dialysis for acetaminophen-induced acute liver failure.
abstract: BACKGROUND
  Extracorporeal support with single-pass albumin dialysis (SPAD) may remove protein-bound toxins in acute liver failure. We evaluated the clinical, physiological and laboratory parameters of SPAD in acetaminophen-induced acute liver failure (AALF).
  
  
  METHODS
  Retrospective case-control studies of AALF patients were used.
  
  
  RESULTS
  We identified 13 AALF patients (6 SPAD-treated, 7 controls). The average age was 38 years, 92% were female, none had cirrhosis and the Model for End-Stage Liver Disease (MELD) scores were 43. Eleven patients (85%) fulfilled the King's College criteria for a liver transplant. SPAD-treated patients received 21 sessions (total: 147 h, mean 3.5 runs or 24.5 h/patient). There were no complications. No significant changes in clinical, physiological or biochemical parameters occurred during SPAD. Compared with the controls, there were no significant differences in ICU or 1-year survival, liver recovery or referral for a liver transplant.
  
  
  CONCLUSIONS
  SPAD was well-tolerated in AALF; however, it was not associated with differences in clinical outcomes. While SPAD may be an adjuvant supportive therapy in AALF, prospective trials are needed.
authors: Division of Critical Care Medicine, University of Alberta, Edmonton, Alta, Canada.
authors: Constantine J
authors: CJ
authors: Karvellas
authors: Sean M
authors: SM
authors: Bagshaw
authors: Robert C
authors: RC
authors: McDermid
authors: Daniel E
authors: DE
authors: Stollery
authors: Vincent G
authors: VG
authors: Bain
authors: R T Noel
authors: RT
authors: Gibney
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012189:Retrospective Studies; D012709:Serum Albumin
chemical_list: D018712:Analgesics, Non-Narcotic; D012709:Serum Albumin; D000082:Acetaminophen