Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy.
OBJECTIVE
To report an ultrastructurally distinct form of paraprotein crystalline keratopathy.


METHODS
Three corneas submitted from a single patient including one native cornea from each eye and a failed corneal graft from the right eye. Light microscopy, immunohistochemistry, immunofluorescence, and transmission electron microscopic examination were performed.


RESULTS
The transmission electron microscopy showed "immunotactoid" extracellular microtubular deposits measuring >30 nm in diameter with a central lucent core.


CONCLUSIONS
Immunotactoid keratopathy is a distinct type of paraprotein crystalline keratopathy associated with a monocolonal immunoglobulin G kappa light chain (IgGk) protein. Larger case series are needed to determine the clinical significance of this entity.
Singh
Kamaljeet
K
Department of Pathology, Rhode Island Hospital and Miriam Hospital, Providence, RI 02903, USA. kamallabana@rediffmail.com
D000368:Aged; D003316:Corneal Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D003319:Corneal Stroma / Q000276:immunology / Q000473:pathology*; D016039:Corneal Transplantation; D006084:Graft Rejection; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007145:Immunoglobulin kappa-Chains / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000150:complications; D008297:Male; D010265:Paraproteinemias / Q000150:complications* / Q000276:immunology / Q000473:pathology
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains