title: Post-cholecystectomy quality of life: a prospective multicenter cohort study of its associations with preoperative functional status and patient demographics.
abstract: OBJECTIVE
  This study analyzed patient demographics and preoperative functional status for associations with post-cholecystectomy quality of life (QOL).
  
  
  METHODS
  This prospective study analyzed 159 cholecystectomy patients at two tertiary academic hospitals. All patients completed the SF-36 and the gastrointestinal quality of life index (GIQLI) at baseline and at 3 and 6 months postoperatively. The 95% confidence intervals for differences in responsiveness estimates were derived by bootstrap estimation. Scores derived by these instruments were interpreted by generalized estimating equation (GEE) before and after cholecystectomy.
  
  
  RESULTS
  The examined population significantly (p < 0.05) improved in both SF-36 subscales and GIQLI subscales. After adjusting for time effects (time, and time(2)) and baseline predictors, GEE approaches revealed the following explanatory variables for QOL: time, time(2), age, gender, preoperative GIQLI score, body mass index, and number of comorbidities.
  
  
  CONCLUSIONS
  The data revealed dramatically improved post-cholecystectomy QOL. However, QOL change was simultaneously associated with preoperative functional status and demographic characteristics.
authors: Graduate Institute of Healthcare Administration, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Hon-Yi
authors: HY
authors: Shi
authors: King-Teh
authors: KT
authors: Lee
authors: Hao-Hsien
authors: HH
authors: Lee
authors: Yih-Huei
authors: YH
authors: Uen
authors: Jinn-Tsong
authors: JT
authors: Tsai
authors: Chong-Chi
authors: CC
authors: Chiu
mesh_terms: D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D002763:Cholecystectomy / Q000379:methods* / Q000523:psychology*; D017081:Cholecystectomy, Laparoscopic / Q000379:methods / Q000523:psychology; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications / Q000453:epidemiology; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011446:Prospective Studies; D011788:Quality of Life; D012086:Reoperation; D018570:Risk Assessment; D012737:Sex Factors; D018434:Sickness Impact Profile