title: Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).
abstract: Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 x 10(-21)), consistent with previous studies, and testosterone (P = 7.54 x 10(-15)), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 x 10(-6)) and SRD5A2 with 3 alpha-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones.
authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors: Jiyoung
authors: J
authors: Ahn
authors: Fredrick R
authors: FR
authors: Schumacher
authors: Sonja I
authors: SI
authors: Berndt
authors: Ruth
authors: R
authors: Pfeiffer
authors: Demetrius
authors: D
authors: Albanes
authors: Gerald L
authors: GL
authors: Andriole
authors: Eva
authors: E
authors: Ardanaz
authors: Heiner
authors: H
authors: Boeing
authors: Bas
authors: B
authors: Bueno-de-Mesquita
authors: Stephen J
authors: SJ
authors: Chanock
authors: Françoise
authors: F
authors: Clavel-Chapelon
authors: W Ryan
authors: WR
authors: Diver
authors: Heather Spencer
authors: HS
authors: Feigelson
authors: J Michael
authors: JM
authors: Gaziano
authors: Edward
authors: E
authors: Giovannucci
authors: Christopher A
authors: CA
authors: Haiman
authors: Brian E
authors: BE
authors: Henderson
authors: Robert N
authors: RN
authors: Hoover
authors: Laurence N
authors: LN
authors: Kolonel
authors: Peter
authors: P
authors: Kraft
authors: Jing
authors: J
authors: Ma
authors: Loïc
authors: L
authors: Le Marchand
authors: Kim
authors: K
authors: Overvad
authors: Domenico
authors: D
authors: Palli
authors: Pär
authors: P
authors: Stattin
authors: Meir
authors: M
authors: Stampfer
authors: Daniel O
authors: DO
authors: Stram
authors: Gilles
authors: G
authors: Thomas
authors: Michael J
authors: MJ
authors: Thun
authors: Ruth C
authors: RC
authors: Travis
authors: Dimitrios
authors: D
authors: Trichopoulos
authors: Jarmo
authors: J
authors: Virtamo
authors: Stephanie J
authors: SJ
authors: Weinstein
authors: Meredith
authors: M
authors: Yeager
authors: Rudolf
authors: R
authors: Kaaks
authors: David J
authors: DJ
authors: Hunter
authors: Richard B
authors: RB
authors: Hayes
mesh_terms: D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D047628:Estrogen Receptor alpha / Q000235:genetics; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000097:blood* / Q000235:genetics* / Q000378:metabolism; D040641:Quantitative Trait Loci; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D044465:White People / Q000235:genetics
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D012739:Gonadal Steroid Hormones; D012738:Sex Hormone-Binding Globulin; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase