title: [Feasibility of the sentinel node biopsy in breast cancer in case of histological multifocality diagnosis].
abstract: OBJECTIVE
  The use of sentinel node biopsy (SNB) has replaced axillary lymph node dissection (ALND) as the new standard of care in early unifocal breast cancer. In multifocal breast cancer, this procedure remains controversial. The real problem is when a multifocal tumor is discovered during or after the surgery, with a SNB negative which has been already done. Should we do an additional ALND or not?
  
  
  METHODS
  We performed a retrospective study of 43 multifocal breast cancer patients who underwent SNB.
  
  
  RESULTS
  The mean histological primary tumor size was 16.8 mm (range, 1-52 mm). The mean number of SN removed was 2.07 (range, 1 to 5). Sixteen (34.1%) of the 43 patients had at least one positive SN. Twenty-seven patients had subsequent axillary dissection. Negative predictive value of SN procedure was 100% (95% confidence interval: 87.1-100%) with a FN rate of 0%. Moreover, not any patient has developed axillary recurrence with a mean follow-up of 20.8 months (1-77).
  
  
  CONCLUSIONS
  Our data are not powerful enough to validate the SNB in multifocal breast tumor discovered after an initial surgery. However, the FN rate of 0% is encouraging and prospective studies with a systematic ALND can help surgeons to respond to the question.
authors: Cancer-Est, service de gynécologie obstétrique et de médecine de la reproduction, hôpital Tenon, AP-HP, université Pierre-et-Marie-Curie-Paris-6, 4, rue de la Chine, 75020 Paris, France. corinne.bezu@tnn.aphp.fr
authors: C
authors: C
authors: Bézu
authors: C
authors: C
authors: Coutant
authors: M
authors: M
authors: Antoine
authors: C
authors: C
authors: Moutafoff
authors: E
authors: E
authors: Guillo
authors: E
authors: E
authors: Daraï
authors: R
authors: R
authors: Rouzier
authors: S
authors: S
authors: Uzan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy