title: Depletion of selective serotonin reuptake inhibitors during sewage sludge composting.
abstract: Sewage and sewage sludge is known to contain pharmaceuticals, and since sewage sludge is often used as fertilizer within agriculture, the reduction of the selective serotonin reuptake inhibitors (SSRIs) Citalopram, Sertraline, Paroxetine, Fluvoxamine and Fluoxetine during composting has been investigated. Sewage sludge was spiked with the SSRIs before the composting experiment started, and the concentration of the SSRIs in the sludge during a 21 day composting period was measured by liquid phase microextraction (LPME) and high-performance liquid chromatography-mass spectrometry. All the SSRIs had a significant decrease in concentration during the composting process. The highest reduction rates were measured for Fluoxetine and Paroxetine and the lowest for Citalopram. In addition three out of four known SSRI metabolites were found in all the samples, and two of them showed a significant increase in concentration during the composting period.
authors: Deparment of Pharmacy, Faculty of Medicine, University of Tromsø, Tromsø N-9037, Norway.
authors: Terje
authors: T
authors: Vasskog
authors: Ove
authors: O
authors: Bergersen
authors: Trude
authors: T
authors: Anderssen
authors: Einar
authors: E
authors: Jensen
authors: Trine
authors: T
authors: Eggen
mesh_terms: D001420:Bacteria, Aerobic / Q000378:metabolism; D001673:Biodegradation, Environmental; D019149:Bioreactors / Q000382:microbiology; D002851:Chromatography, High Pressure Liquid; D015283:Citalopram / Q000032:analysis / Q000378:metabolism; D005473:Fluoxetine / Q000032:analysis / Q000378:metabolism; D017374:Paroxetine / Q000032:analysis / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis* / Q000378:metabolism; D012722:Sewage / Q000737:chemistry*; D012989:Soil Pollutants / Q000032:analysis*; D014865:Waste Disposal, Fluid / Q000379:methods*
chemical_list: D015283:Citalopram; D005473:Fluoxetine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D012722:Sewage; D012989:Soil Pollutants