title: Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention.
abstract: In this issue of Cell Metabolism, Kaufman and colleagues (Back et al., 2009) elegantly demonstrate that appropriate regulation of eIF2alpha phosphorylation improves glucose tolerance and beta cell viability by preventing the lethal buildup of oxidative damage due to unregulated synthesis, trafficking, and misfolding of proteins.
authors: Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. rwek@iupui.edu
authors: Ronald C
authors: RC
authors: Wek
authors: Tracy G
authors: TG
authors: Anthony
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000378:metabolism*; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D051379:Mice; D018384:Oxidative Stress; D010766:Phosphorylation
chemical_list: D000975:Antioxidants; D015852:Eukaryotic Initiation Factor-2