title: Difference in leptin hormone response to nutritional status in normal adult male albino rats.
abstract: The present study investigated the effect of 14 days diet, enriched in butter, vitamin E (vit. E) and green tea, on the major regulators of energy expenditure. Leptin is the product OB gene. This 16 KDa protein is produced by mature adipocytes and is secreted in plasma. Its plasma levels are strongly correlated with adipose mass in rodents as well as in humans. Leptin inhibit food intake, reduces body weight and stimulates energy expenditure. In order to evaluate the effect of diet enriched in butter, vit. E and green tea on body weight, adipose tissue weight and organs weight, serum lipids, lipoproteins content and serum leptin levels in male albino rats supplemented for 14 days on the previous diet. This study showed that high fat diet significantly increased body weight and adipose tissue weight, while vit. E and green tea enriched diet significantly lowered body weight and adipose tissue weight, kidney and spleen weights didn't show significant changes in all the experimental groups. While liver weight decreased in diet supplemented with high fat diet. Also, the results showed that high fat diet and vit. E supplemented diet induced significant increase in total cholesterol, LDLc., triglyceride level with significant decrease in HDLc. level as compared to normal control rats. Finally green tea supplemented diet induced significant decrease in total cholesterol, LDLc., triglyceride level with insignificant increase in HDLc. level in control rats. On the other hand, high fat supplemented diet significantly increased serum leptin levels in rats compared to control group, while vit. E and green tea enriched diet significantly lowered serum leptin levels at the end of experimental period. In conclusion, improving the biological activity of leptin by diet modification may exist as a practical strategy for the treatment of obesity and related disorders and a diet rich in green tea to reduce the risk of cardiovascular disease (CVD) obesity and also protect the liver against free radicals.
authors: Department of Animal Sciences, Faculty of Education, AL-Qassim University, Saudi Arabia.
authors: Noorah S
authors: NS
authors: Al-Sowyan
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D001835:Body Weight / Q000502:physiology*; D004032:Diet; D004041:Dietary Fats / Q000378:metabolism; D019587:Dietary Supplements; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D008297:Male; D009752:Nutritional Status; D009765:Obesity / Q000378:metabolism; D009929:Organ Size; D051381:Rats; D013662:Tea / Q000737:chemistry / Q000378:metabolism; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D020738:Leptin; D013662:Tea; D014810:Vitamin E