Anodic fabrication and bioactivity of Nb-doped TiO2 nanotubes.
We report anodic formation of Ti-Nb-O nanotubes on top of a Ti35Nb alloy, and in vitro bioactivity and stem cell response of the anodic nanotubes. It was found that the amorphous Ti-Nb-O nanotubes presented a significantly enhanced in vitro bioactivity (in simulated body fluids) compared to those of undoped TiO2 nanotubes and porous Ti-Nb-O without nanotubular structure. Similar to undoped TiO2 nanotubes, the Ti-Nb-O nanotubes also promote mesenchymal stem cell adhesion and fast formation of extracellular matrix (ECM) materials. The above findings make it possible to further explore the biological properties, such as cell proliferation and drug delivery, of a variety of Ti-alloy-based oxide nanotubes.
Ding
Dongyan
D
Lab of Microelectronic Materials and Technology, State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Ning
Congqin
C
Huang
Lin
L
Jin
Fangchun
F
Hao
Yongqiang
Y
Bai
Shuo
S
Li
Yan
Y
Li
Ming
M
Mao
Dali
D
D000497:Alloys / Q000737:chemistry; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002478:Cells, Cultured; D004566:Electrodes; D005109:Extracellular Matrix / Q000378:metabolism; D051379:Mice; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D009556:Niobium / Q000737:chemistry*; D013234:Stem Cells / Q000502:physiology; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
D000497:Alloys; D009556:Niobium; C009495:titanium dioxide; D014025:Titanium