title: Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors.
abstract: A novel class of imidazopyridine derivatives was designed as PLK1 inhibitors. Extensive SAR studies supported by molecular modeling afforded a highly potent and selective compound 36. Compound 36 demonstrated good antitumor efficacy in xenograft nude rat model.
authors: Banyu Tsukuba Research Institute, Merck Research Laboratories, Banyu Pharmaceutical Co, Ltd, Tsukuba, Ibaraki 300-2611, Japan.
authors: Yoshiyuki
authors: Y
authors: Sato
authors: Yu
authors: Y
authors: Onozaki
authors: Tetsuya
authors: T
authors: Sugimoto
authors: Hideki
authors: H
authors: Kurihara
authors: Kaori
authors: K
authors: Kamijo
authors: Chie
authors: C
authors: Kadowaki
authors: Toshiaki
authors: T
authors: Tsujino
authors: Akiko
authors: A
authors: Watanabe
authors: Sachie
authors: S
authors: Otsuki
authors: Morihiro
authors: M
authors: Mitsuya
authors: Masato
authors: M
authors: Iida
authors: Kyosuke
authors: K
authors: Haze
authors: Takumitsu
authors: T
authors: Machida
authors: Yoko
authors: Y
authors: Nakatsuru
authors: Hideya
authors: H
authors: Komatani
authors: Hidehito
authors: H
authors: Kotani
authors: Yoshikazu
authors: Y
authors: Iwasawa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D045744:Cell Line, Tumor; D003198:Computer Simulation; D006367:HeLa Cells; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008956:Models, Chemical; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D023041:Xenograft Model Antitumor Assays; D000097869:Polo-Like Kinase 1
chemical_list: D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D007093:Imidazoles; D047428:Protein Kinase Inhibitors; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D011725:Pyridines; D000097869:Polo-Like Kinase 1