title: Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy.
abstract: Fine needle aspiration biopsy (FNAB) is the preferred technique for the initial diagnostic evaluation of thyroid lesions, which nevertheless poses a diagnostic challenge for all clinicians involved. The latter necessitates the use of molecular markers on thyroid cytology. MIB-1 is a molecular marker already used in the cytological evaluation of various tumors. In this study, we assessed whether MIB-1 proliferation index adds diagnostic information to the conventional cytological analysis of thyroid nodules and prognostic information in thyroid cancers. MIB-1 index for various thyroid lesions was retrospectively reviewed in a series of 504 patients. Furthermore, the prognostic value of MIB-1 index was investigated for 183 of the patients with papillary thyroid cancer (PTC). MIB-1 index was significantly higher in anaplastic thyroid cancer (ATC) compared to other tumor types (p<0.01). No significant difference in MIB-1 index was observed between thyroid adenomas and follicular carcinomas. In PTC, MIB-1 index equal to or >4% was found to be an independent factor significantly associated with higher risk of distant metastasis and disease-related mortality (p<0.05). Conclusively, this study shows that preoperative MIB-1 index assessment in FNAB of thyroid nodules offers little diagnostic information as far as follicular tumors are concerned. In cases of PTC, though, MIB-1 may serve as a prognostic indicator of disease spreading and poor survival and hence influence the planning of the overall treatment scheme.
authors: Karolinska University Hospital (Solna), SE-171 76, Stockholm, Sweden. anastasios.sofiadis@ki.se
authors: Anastasios
authors: A
authors: Sofiadis
authors: Edneia
authors: E
authors: Tani
authors: Theodoros
authors: T
authors: Foukakis
authors: Petra
authors: P
authors: Kjellman
authors: Lambert
authors: L
authors: Skoog
authors: Anders
authors: A
authors: Höög
authors: Göran
authors: G
authors: Wallin
authors: Jan
authors: J
authors: Zedenius
authors: Catharina
authors: C
authors: Larsson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001707:Biopsy, Needle; D002291:Carcinoma, Papillary / Q000473:pathology; D049109:Cell Proliferation; D002648:Child; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000401:mortality / Q000473:pathology*
chemical_list: D000974:Antibodies, Antinuclear; D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; C440408:MIB-1 antibody