Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer.
BACKGROUND
In the present study, the effect of immunochemotherapy with lentinan compared with that of chemotherapy alone was evaluated in patients with advanced gastric cancer through individual patient data (IPD) meta-analysis.


METHODS
Based on a computerized and manual search, all eligible centrally randomized controlled trials (RCT) which compared chemotherapy regimens with or without lentinan administration for advanced gastric cancer patients were included.


RESULTS
In total, 650 IPD from 5 trials were available. Lentinan significantly prolonged the overall survival (stratified log-rank p=0.011). The overall hazard ratio (HR) was 0.80 (95% confidence interval=0.68-0.95) and there was no heterogeneity between trials. Additionally, lentinan was possibly more effective in patients with lymph-node metastasis than in non-node metastasis patients (P for interaction=0.077).


CONCLUSIONS
The addition of lentinan to standard chemotherapy offers a significant advantage over chemotherapy alone in terms of survival for patients with advanced gastric cancer.
Oba
Koji
K
EBM Research Center, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Kyoto, Japan. oba@pbh.med.kyoto-u.ac.jp
Kobayashi
Michiya
M
Matsui
Takanori
T
Kodera
Yasuhiro
Y
Sakamoto
Junichi
J
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007912:Lentinan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D007912:Lentinan