Role of high risk-human papilloma virus test in the follow-up of patients who underwent conization of the cervix for cervical intraepithelial neoplasia.
OBJECTIVE
To examine whether the presence of high risk-human papilloma virus (HR-HPV) after conization of the cervix was a risk factor for persistence or recurrence of cervical intraepithelial neoplasia (CIN) and whether HR-HPV test could be a guideline for post-therapy surveillance.


METHODS
The study retrospectively analyzed data from 243 patients who underwent LLETZ or CKC of the cervix due to CIN.


RESULTS
A positive HR-HPV test result which was performed between 3 and 6 months after procedure was a risk factor for persistent or recurrent cytological (p<0.001, odds ratio [OR]=22.51, 95% confidence interval [CI]=9.74-52.02) and pathological (p<0.001, OR=18.28, 95% CI=5.55-60.20) abnormalities.


CONCLUSIONS
HR-HPV positive patients between 3 and 6 months after procedure should undergo frequent and meticulous post-therapy surveillance, while HR-HPV negative patients do not require such high-level surveillance and could undergo routine surveillance.
Park
Jeong-Yeol
JY
Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Bae
Jaeman
J
Lim
Myong Cheol
MC
Lim
So Yi
SY
Lee
Dong-Ock
DO
Kang
Sokbom
S
Park
Sang-Yoon
SY
Nam
Byung-Ho
BH
Seo
Sang-Soo
SS