Alkaline pH enhances farnesol production by Saccharomyces cerevisiae.
External environments affect prenyl alcohol production by squalene synthetase-deficient mutant Saccharomyces cerevisiae ATCC 64031. Cultivation of the yeast in medium with an initial pH ranging from 7.0 to 8.0 increased the amount of secreted farnesol (FOH). In contrast, acidic medium with a pH below 4.0 increased the intracellular FOH and its isomer nerolidol. These effects of alkaline pH were also observed on constant pH cultivation in a jar fermenter. On cultivation for 133 h, the FOH production reached 102.8 mg/l.
Muramatsu
Masayoshi
M
Bio Research Lab., Toyota Motor Corporation, Toyota 471-8572, Japan.
Ohto
Chikara
C
Obata
Shusei
S
Sakuradani
Eiji
E
Shimizu
Sakayu
S
D003470:Culture Media; D005204:Farnesol / Q000378:metabolism*; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D012441:Saccharomyces cerevisiae / Q000378:metabolism*
D003470:Culture Media; D005204:Farnesol