Probing a sialyltransferase's recognition domain to prepare alpha(2,8)-linked oligosialosides and analogs.
We report the first observation that a monosialyl residue is the essential structural element recognized by the enzyme CST-II; this has resulted in an attractive route to synthesize a series of alpha(2,8)-linked oligosialic acids and their thioanalogs in one step.
Zhang
Ping
P
Alberta Ingenuity Centre for Carbohydrate Science, Department of Chemistry, University of Calgary, 2500, University Drive NW, Calgary, Alberta, Canada T2N 1N4.
Zuccolo
Amir J
AJ
Li
Wenling
W
Zheng
Ruixiang Blake
RB
Ling
Chang-Chun
CC
D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D012794:Sialic Acids / Q000737:chemistry / Q000378:metabolism*; D012799:Sialyltransferases / Q000378:metabolism*
D012794:Sialic Acids; D012799:Sialyltransferases