title: Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma.
abstract: Malignant peritoneal mesothelioma is a rare neoplasm with a rapidly fatal course. The response of this disease to treatment is poor because it tends to be advanced at diagnosis and tends to have inherent resistance to chemotherapeutic treatment. We describe three patients with malignant peritoneal mesothelioma who received combination chemotherapy with cisplatin and gemcitabine. After a histopathological diagnosis of epithelial-type malignant peritoneal mesothelioma, all patients underwent systemic chemotherapy because of the advanced disease stage. Moreover, one patient would have been at high risk of cardiac events, because of congenital heart malformation if complete surgical resection had been performed. This chemotherapy achieved a partial response in two patients, but had no effect in one. Combination chemotherapy with cisplatin and gemcitabine may prove to be one of the recommended treatments for patients with malignant peritoneal mesothelioma in the near future.
authors: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
authors: Satoshi
authors: S
authors: Tanida
authors: Hiromi
authors: H
authors: Kataoka
authors: Eiji
authors: E
authors: Kubota
authors: Yoshinori
authors: Y
authors: Mori
authors: Makoto
authors: M
authors: Sasaki
authors: Naotaka
authors: N
authors: Ogasawara
authors: Tsuneya
authors: T
authors: Wada
authors: Tsutomu
authors: T
authors: Mizoshita
authors: Takaya
authors: T
authors: Shimura
authors: Kenji
authors: K
authors: Murakami
authors: Takashi
authors: T
authors: Mizushima
authors: Yoshikazu
authors: Y
authors: Hirata
authors: Yasuyuki
authors: Y
authors: Okamoto
authors: Motoshi
authors: M
authors: Mabuchi
authors: Masahide
authors: M
authors: Ebi
authors: Mamoru
authors: M
authors: Tanaka
authors: Takeshi
authors: T
authors: Kamiya
authors: Satoru
authors: S
authors: Takahashi
authors: Takashi
authors: T
authors: Joh
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy*; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D000093542:Gemcitabine
chemical_list: D002272:Carcinoembryonic Antigen; D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine