Increased prevalence of anti-gliadin antibodies and anti-tissue transglutaminase antibodies in children with cerebral palsy.
OBJECTIVE
The aim of the study was to investigate whether there is any association between cerebral palsy (CP) and celiac disease (CD) in children.


METHODS
Ninety children between 18 months and 18 years of age (median 9 years) with CP were included. Antibodies (IgA and IgG) against gliadin (AGA), endomysium (EMA), and tissue transglutaminase (tTG) were measured. Children with elevated levels of these antibodies were offered a small-bowel biopsy.


RESULTS
Thirty-nine children showed an elevated level of 1 or more of the tested antibodies (43%). None had raised EMA antibodies. Presence of tetraplegia or dyskinesia was associated with increased antibody levels (P=0.045), as was a more severe functional type of CP (P=0.008). Children with elevated antibodies had a lower body weight (P=0.049), height (P=0.041), and body mass index (BMI) (P=0.014). Small-bowel biopsies were performed in 27 out of 39 children; 1 had CD and 2 had intraepithelial lymphocytosis.


CONCLUSIONS
A large number of children with CP had elevated AGA and/or anti-tTG. Because these elevations were associated with lower weight, height, and BMI, it seemed of interest to speculate on how these findings correlated to CP and CD. However, we found no correlation between CP and CD.
Stenberg
Reidun
R
Department of Pediatrics, Orebro University Hospital, Orebro University, Orebro, Sweden.
Dahle
Charlotte
C
Lindberg
Eva
E
Schollin
Jens
J
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D001706:Biopsy; D015992:Body Mass Index; D049628:Body Size; D002446:Celiac Disease / Q000150:complications* / Q000276:immunology; D002547:Cerebral Palsy / Q000097:blood / Q000150:complications / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D007413:Intestinal Mucosa / Q000276:immunology; D007421:Intestine, Small / Q000276:immunology; D008218:Lymphocytosis / Q000150:complications; D008297:Male; D011503:Transglutaminases / Q000276:immunology*
D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin; D011503:Transglutaminases