[Successful treatment of treatment-resistant opioid-induced constipation in a patient with incomplete paraplegia with methylnaltrexone].
We observed a patient with incomplete, cervical paraplegia and opioid-induced constipation who developed a resistance to laxatives after 15 years of treatment. The constipation-induced reduction in the patient's quality of life was improved using 12 mg methylnaltrexone, a peripheral mu-opioid receptor antagonist, administered subcutaneously twice a week.
Lux
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EA
Klinik für Schmerz- und Palliativmedizin, Klinikum St.-Marien-Hospital, Altstadtstr.23, 44534 Lünen. drlux@web.de
D000368:Aged; D002574:Cervical Vertebrae / Q000601:surgery; D003248:Constipation / Q000139:chemically induced* / Q000188:drug therapy*; D005244:Fecal Impaction / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D009271:Naltrexone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D009294:Narcotics / Q000009:adverse effects* / Q000627:therapeutic use; D010264:Paraplegia / Q000150:complications*; D011183:Postoperative Complications / Q000188:drug therapy; D000644:Quaternary Ammonium Compounds / Q000009:adverse effects / Q000627:therapeutic use; D013117:Spinal Cord Compression / Q000601:surgery
D009292:Narcotic Antagonists; D009294:Narcotics; D000644:Quaternary Ammonium Compounds; C032257:methylnaltrexone; D009271:Naltrexone