Organocatalysts immobilised onto gold nanoparticles: application in the asymmetric reduction of imines with trichlorosilane.
Gold nanoparticles functionalised with a valine-derived formamide have been developed as effective homogenous catalysts for the asymmetric reduction of ketimine 1 with trichlorosilane (< or = 84% ee) in toluene. This methodology both simplifies the recovery of the catalyst and its separation from the product, as the nanoparticles can be readily removed and subsequently recycled by precipitation from the reaction mixture.
Malkov
Andrei V
AV
WestCHEM, Department of Chemistry, Joseph Black Building, University of Glasgow, Glasgow, UK G12 8QQ. A.Malkov@lboro.ac.uk
Figlus
Marek
M
Cooke
Graeme
G
Caldwell
Stuart T
ST
Rabani
Gouher
G
Prestly
Mark R
MR
Kocovský
Pavel
P
D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism; D008063:Thioctic Acid / Q000737:chemistry
D007097:Imines; D012821:Silanes; D008063:Thioctic Acid; D006046:Gold; C065893:trichlorosilane