Inhibition of lung metastasis in mice by intravascular injection of dendritic cells and natural killer cells.
To investigate the efficacy of dendritic cells and natural killer cells in the inhibition of lung metastasis, we injected dendritic cells and natural killer cells intravascularly into mice bearing B16F10 tumour melanoma cells. This efficiently inhibited tumor growth and prolonged survival. In addition, surviving mice developed a long-lasting memory response against the original tumor when re-challenged with live tumor cells. Intravenous administration of dendritic cells and natural killer cells may be a potential way to treat lung metastasis in patients.
Lv
Hui-fang
HF
Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, 150086, 246 Xuefu Road, Nangang District, Harbin, Heilongjiang, China.
Cui
Feng
F
Yu
Chang-hua
CH
Deng
Li-li
LL
Ji
Jing-jing
JJ
Lu
Dan
D
Yang
Yu
Y
Wang
Wen-xiu
WX
Xu
Yu-qing
YQ
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D004333:Drug Administration Routes; D005260:Female; D007156:Immunologic Memory / Q000276:immunology; D007275:Injections, Intravenous; D007694:Killer Cells, Natural / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology / Q000517:prevention & control* / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL