title: The changing face of HIV/AIDS in treated patients.
abstract: The spectrum of complications emerging in successfully treated HIV-infected patients has dramatically changed since the advent of HAART. Typical AIDS-defining illnesses have been substituted by new comorbid conditions that threaten even those patients who maintain virologic suppression. Proper management of cardiovascular risk, and early diagnosis of AIDS-related and, particularly, non-AIDS-related malignancies (including papilomavirus-related neoplasms) must be introduced into the routine of care. Hot areas of investigation include HIV-associated neurocognitive disorders, hepatitis B and C coinfection, non-alcoholic fatty liver disease, progressive multifocal leukoencephalopathy and tuberculosis. Bone and kidney long-term toxicities and lipoatrophy remain as issues of paramount importance. The identification and early treatment of immune reconstitution disease is also of major interest, specially in those patients starting their antiretroviral treatment with severe CD4 cell depletion. The present review focuses on these twelve areas of increasing interest for physicians currently facing successfully treated HIV+ patients.
authors: Lluita Contra la SIDA Foundation, University Hospital Germans Trias, Barcelona 08916, Spain. jmllibre@flsida.org
authors: Josep M
authors: JM
authors: Llibre
authors: Vicenç
authors: V
authors: Falco
authors: Cristina
authors: C
authors: Tural
authors: Eugenia
authors: E
authors: Negredo
authors: Juan A
authors: JA
authors: Pineda
authors: Jose
authors: J
authors: Muñoz
authors: Enrique
authors: E
authors: Ortega
authors: Sebastia
authors: S
authors: Videla
authors: Guillem
authors: G
authors: Sirera
authors: Esteban
authors: E
authors: Martinez
authors: Celia
authors: C
authors: Miralles
authors: Josean
authors: J
authors: Iribarren
authors: Maria J
authors: MJ
authors: Galindo
authors: Pere
authors: P
authors: Domingo
authors: Antonella
authors: A
authors: d'Arminio-Monforte
authors: Jose M
authors: JM
authors: Miro
authors: Bonaventura
authors: B
authors: Clotet
mesh_terms: D000386:AIDS-Related Complex / Q000453:epidemiology / Q000628:therapy; D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000628:therapy; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000628:therapy; D039682:HIV-Associated Lipodystrophy Syndrome / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000628:therapy; D016483:Lymphoma, AIDS-Related / Q000453:epidemiology / Q000628:therapy; D009369:Neoplasms / Q000453:epidemiology / Q000628:therapy
chemical_list: D019380:Anti-HIV Agents