Activity of (-)alpha-bisabolol against Leishmania infantum promastigotes.
Many of the drugs used to treat leishmaniasis are associated with numerous adverse effects. Agents of natural origin have shown activity against different parasites. With this background, an in vitro study was conducted on the activity of (-)alpha-bisabolol, the principal component of Chamomilla recutita essential oil, against Leishmania infantum promastigotes, the main species responsible for human leishmaniasis in Spain. At the two highest concentrations tested (1000 and 500mug/ml), (-)alpha-bisabolol and pentamidine (control agent) achieved 100% inhibition of L. infantum promastigote. These in vitro data can be considered promising in support of the therapeutic use of (-)alpha-bisabolol preparations to treat leishmaniasis caused by L. infantum species.
Morales-Yuste
M
M
Facultad de Farmacia, Departamento de Parasitología, Universidad de Granada, Granada, Spain.
Morillas-Márquez
F
F
Martín-Sánchez
J
J
Valero-López
A
A
Navarro-Moll
M C
MC
D000981:Antiprotozoal Agents / Q000494:pharmacology*; D018314:Leishmania infantum / Q000187:drug effects*; D031168:Matricaria / Q000737:chemistry*; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010419:Pentamidine / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; D012717:Sesquiterpenes; C004497:bisabolol; D010419:Pentamidine