Immune modulation by lactoferrin and curcumin in children with recurrent respiratory infections.
The clinical and immunologic effects of lactoferrin and curcumin (LC) oral supplementation were examined in healthy children with recurrent respiratory tract infections. Infections were reduced in children receiving LC. Immunologic analyses showed that LC supplementation resulted in a significant skewing of CD8+T lymphocytes maturation. Additionally: 1) CD14+, toll like receptor (TLR) 2-expressing cells augmented (p= 0.005) whereas CD14+/TLR4+ diminished (p= 0.004); and 2) IL10 production by CD14+ cells was reduced in children receiving LC. LC supplementation results in immune modulation and could be clinically beneficial.
Zuccotti
G V
GV
Department of Paediatrics, L. Sacco Hospital, University of Milan, Italy.
Trabattoni
D
D
Morelli
M
M
Borgonovo
S
S
Schneider
L
L
Clerici
M
M
D000284:Administration, Oral; D002648:Child; D002675:Child, Preschool; D003474:Curcumin / Q000008:administration & dosage / Q000627:therapeutic use*; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D007781:Lactoferrin / Q000008:administration & dosage / Q000627:therapeutic use*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D051195:Toll-Like Receptor 2 / Q000378:metabolism
D016207:Cytokines; D007155:Immunologic Factors; D018950:Lipopolysaccharide Receptors; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2; D007781:Lactoferrin; D003474:Curcumin