title: Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging.
abstract: Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe(3)O(4)) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.
authors: Department of Biomedical Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan. sabe@den.hokudai.ac.jp
authors: Shigeaki
authors: S
authors: Abe
authors: Ikuhiro
authors: I
authors: Kida
authors: Mitsue
authors: M
authors: Esaki
authors: Tsukasa
authors: T
authors: Akasaka
authors: Motohiro
authors: M
authors: Uo
authors: Toshiaki
authors: T
authors: Hosono
authors: Yoshinori
authors: Y
authors: Sato
authors: Balachandran
authors: B
authors: Jeyadevan
authors: Yoshinori
authors: Y
authors: Kuboki
authors: Manabu
authors: M
authors: Morita
authors: Kazuyuki
authors: K
authors: Tohji
authors: Fumio
authors: F
authors: Watari
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics*; D052203:Ferrosoferric Oxide / Q000737:chemistry* / Q000493:pharmacokinetics*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008856:Microscopy, Fluorescence / Q000379:methods; D009928:Organ Specificity; D014018:Tissue Distribution; D051598:Whole Body Imaging / Q000379:methods*; D014965:X-Rays
chemical_list: D003287:Contrast Media; D052203:Ferrosoferric Oxide