Characterization and ligand specificity of sheep IgG2 receptor.
Neutrophils and macrophages in cattle express a novel class of immunoglobulin Fc receptor, specific for bovine IgG2, termed boFcgamma2R. In cows, the ability of neutrophils to kill immunoglobulin-opsonized microorganisms appears to depend largely on this subclass. Although related to other mammalian FcgammaRs, boFcgamma2R belongs to a novel gene family that includes the human killer Ig-like receptor and FcalphaRI (CD89) proteins. In this study, we describe the presence and characterization of this novel class of FcgammaR in sheep. The comparative analysis of this novel FcgammaR has allowed us to begin an exploration of some immunological characteristic of ruminants.
Qiao
Songlin
S
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China.
Yang
Yanyan
Y
Liu
Yunchao
Y
Zhang
Gaiping
G
Xi
Jun
J
Zhang
Hong
H
Hao
Huifang
H
Tian
Xiaohui
X
Yang
Suzhen
S
Deng
Ruiguang
R
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019556:COS Cells; D002417:Cattle; D002522:Chlorocebus aethiops; D017931:DNA Primers / Q000235:genetics; D006801:Humans; D055261:Immunogenetic Phenomena; D007074:Immunoglobulin G / Q000378:metabolism*; D008024:Ligands; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017452:Receptors, IgG / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D012756:Sheep / Q000235:genetics* / Q000276:immunology*; D013045:Species Specificity; D014162:Transfection
D017931:DNA Primers; D007074:Immunoglobulin G; D008024:Ligands; D012333:RNA, Messenger; D017452:Receptors, IgG; D011994:Recombinant Proteins