[A case of mesalazine-induced lung injury improved by only discontinuation of mesalazine].
We reported a case of drug-induced lung injury associated with mesalazine. A 50-year-old woman was diagnosed as having ulcerative colitis and treated with mesalazine. After administration for 1 month, the patient developed dry cough, fever and bilateral pulmonary infiltrates. A bronchoalveolar lavage showed 6.5 x 10(5) cells/ml, with 58% lymphocytes and 20% eosinophils. Improvement in clinical symptoms and radiological abnormalities occurred spontaneously after discontinuation of mesalazine. Even though the signs and symptoms of mesalazine-induced lung injury are similar to those of the pulmonary involvement of inflammatory bowel disease, it is important to distinguish them differences.
Shimizu
Takashi
T
Department of Internal Medicine, Joetsu General Hospital.
Hayashi
Masachika
M
Shimizu
Natsue
N
Kinebuchi
Shin-ichi
S
Toyama
Jozi
J
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D019804:Mesalamine / Q000009:adverse effects*; D008875:Middle Aged
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine