Antimicrobial and immunomodulatory properties of prenylated xanthones from twigs of Garcinia staudtii.
Phytochemical investigation of the methanol extract of the twigs of Garcinia staudtii yielded four new prenylated xanthones, staudtiixanthones A-D (1-4), along with eleven known compounds. Their structures were determined by analysis of 1D and 2D NMR spectra and by comparison of spectroscopic data with those previously reported. Some of these compounds have been evaluated for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The new compounds were also screened for phagocyte chemiluminescence, neutrophil chemotaxis, T-cell proliferation, cytokine production from mononuclear cells and cytotoxicity. They were found to exhibit potent immunomodulatory activities.
Ngoupayo
Joseph
J
Département de Pharmacie et Pharmacothérapeutique Africaine, Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé 1, BP 1364 Yaoundé, Cameroun. jngoupayo@yahoo.fr
Tabopda
Turibio Kuiate
TK
Ali
Muhammad Shaiq
MS
D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002417:Cattle; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects; D016207:Cytokines / Q000276:immunology; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007668:Kidney / Q000166:cytology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D015394:Molecular Structure; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D010084:Oxidation-Reduction; D010586:Phagocytes / Q000187:drug effects / Q000378:metabolism; D018520:Plant Shoots / Q000737:chemistry; D054876:Prenylation; D013601:T-Lymphocytes / Q000166:cytology; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000890:Anti-Infective Agents; D016207:Cytokines; D007155:Immunologic Factors; D044004:Xanthones