Detection of PARV4, genotypes 1 and 2, in healthy and pathological clinical specimens.
The molecular epidemiology and tissue distribution of Human Parvovirus 4 (PARV4) and its variant PARV5 (Parvoviridae family) are poorly known. The aim of this study was to investigate the epidemiological role and prevalence of PARV4/5 by a nested-PCR on different clinical specimens, including blood samples from healthy donors, healthy and pathological skin samples, and bronchoalveolar lavages (BAL). Among blood specimens, 2/53 were positive; 3/37 and 23/105 of healthy and pathological skin specimens resulted positive, respectively, whereas no BAL was positive. PARV4/5 may be present in different healthy and pathological samples, suggesting the need for further investigating its tissue distribution.
Botto
Sara
S
Department of Public Health and Microbiology, Virology Unit, Turin University, Italy.
Bergallo
Massimiliano
M
Sidoti
Francesca
F
Terlizzi
Maria Elena
ME
Astegiano
Sara
S
Ponti
Renata
R
Costa
Cristina
C
Cavallo
Rossana
R
D000328:Adult; D000368:Aged; D001769:Blood / Q000821:virology; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D017992:Parvovirus / Q000235:genetics* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012867:Skin / Q000821:virology
D004279:DNA, Viral