Thermal antinociception after dexmedetomidine administration in cats: a comparison between intramuscular and oral transmucosal administration.
Dexmedetomidine 40microg/kg was administered either intramuscularly (IM) or oral transmucosally (OTM) to 12 cats in a randomised cross-over study. Thermal nociceptive thresholds and visual analogue scale (VAS) sedation scores were obtained before and at regular intervals up to 24h after test drug administration. The summary measures of overall mean threshold, overall mean VAS sedation plus onset, offset and duration of analgesia were investigated using a univariate general linear model. There were no significant differences between treatment groups. Data are presented as mean+/-standard deviation: delta T mean increase over time (IM 6 degrees C+/-3 degrees C, OTM 6 degrees C+/-2 degrees C); overall mean VAS (IM 43+/-9 OTM 39+/-1); onset (IM 35+/-32 and OTM 30+/-40min); offset (IM 96+/-56 and OTM 138+/-135min); duration (IM 61+/-47 OTM 99+/-124min). Dexmedetomidine is well absorbed through the oral mucosa in cats since OTM and IM administration of dexmedetomidine 40microg/kg produced similar overall sedative and antinociceptive effects.
Slingsby
Louisa S
LS
School of Clinical Veterinary Science, University of Bristol, Bristol, UK. Louisa.Slingsby@bristol.ac.uk
Taylor
Polly M
PM
Monroe
Taylor
T
D000284:Administration, Oral; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D018592:Cross-Over Studies; D020927:Dexmedetomidine / Q000494:pharmacology*; D005260:Female; D006358:Hot Temperature; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007273:Injections, Intramuscular; D016014:Linear Models; D008297:Male; D010147:Pain Measurement / Q000187:drug effects / Q000662:veterinary
D000700:Analgesics; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine