title: Genome-wide association study identifies five susceptibility loci for glioma.
abstract: To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.
authors: Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
authors: Sanjay
authors: S
authors: Shete
authors: Fay J
authors: FJ
authors: Hosking
authors: Lindsay B
authors: LB
authors: Robertson
authors: Sara E
authors: SE
authors: Dobbins
authors: Marc
authors: M
authors: Sanson
authors: Beatrice
authors: B
authors: Malmer
authors: Matthias
authors: M
authors: Simon
authors: Yannick
authors: Y
authors: Marie
authors: Blandine
authors: B
authors: Boisselier
authors: Jean-Yves
authors: JY
authors: Delattre
authors: Khe
authors: K
authors: Hoang-Xuan
authors: Soufiane
authors: S
authors: El Hallani
authors: Ahmed
authors: A
authors: Idbaih
authors: Diana
authors: D
authors: Zelenika
authors: Ulrika
authors: U
authors: Andersson
authors: Roger
authors: R
authors: Henriksson
authors: A Tommy
authors: AT
authors: Bergenheim
authors: Maria
authors: M
authors: Feychting
authors: Stefan
authors: S
authors: Lönn
authors: Anders
authors: A
authors: Ahlbom
authors: Johannes
authors: J
authors: Schramm
authors: Michael
authors: M
authors: Linnebank
authors: Kari
authors: K
authors: Hemminki
authors: Rajiv
authors: R
authors: Kumar
authors: Sarah J
authors: SJ
authors: Hepworth
authors: Amy
authors: A
authors: Price
authors: Georgina
authors: G
authors: Armstrong
authors: Yanhong
authors: Y
authors: Liu
authors: Xiangjun
authors: X
authors: Gu
authors: Robert
authors: R
authors: Yu
authors: Ching
authors: C
authors: Lau
authors: Minouk
authors: M
authors: Schoemaker
authors: Kenneth
authors: K
authors: Muir
authors: Anthony
authors: A
authors: Swerdlow
authors: Mark
authors: M
authors: Lathrop
authors: Melissa
authors: M
authors: Bondy
authors: Richard S
authors: RS
authors: Houlston
mesh_terms: D000483:Alleles; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005910:Glioma / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015203:Reproducibility of Results