Remarkable effect of 2,2'-bipyridyl: mild and highly chemoselective deprotection of methoxymethyl (MOM) ethers in combination with TMSOTf (TESOTf)-2,2'-bipyridyl.
The remarkable effect of 2,2'-bipyridyl led to the successful development of the mild and highly chemoselective deprotection method of methoxymethyl (MOM) ethers using the combination of TMSOTf (or TESOTf) and 2,2'-bipyridyl; this method can be applied to the direct conversion of the MOM group to other ethereal protective groups (e.g. benzyloxymethyl) with the corresponding alcohols.
Fujioka
Hiromichi
H
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. fujioka@phs.osaka-u.ac.jp
Kubo
Ozora
O
Senami
Kento
K
Minamitsuji
Yutaka
Y
Maegawa
Tomohiro
T
D015082:2,2'-Dipyridyl / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry* / Q000145:classification; D007202:Indicators and Reagents / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D008697:Methane / Q000737:chemistry* / Q000145:classification; D015394:Molecular Structure; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
D004987:Ethers; D007202:Indicators and Reagents; D008698:Mesylates; D014297:Trimethylsilyl Compounds; C053353:trimethylsilyl trifluoromethanesulfonate; D015082:2,2'-Dipyridyl; D008697:Methane