Breathing mechanics during exercise with added dead space reflect mechanisms of ventilatory control.
Small increases in external dead space (V(D)) augment the exercise ventilatory response via a neural mechanism known as short-term modulation (STM). We hypothesized that breathing mechanics would differ during exercise, increased V(D) and STM. Men were studied at rest and during cycle exercise (10-50W) without (Control) and with added V(D) (200-600ml). With added V(D), V(T) increased via increased end-inspiratory lung volume (EILV), with no change in end-expiratory lung volume (EELV), indicating recruitment of inspiratory muscles only. With exercise, V(T) increased via both decreased EELV and increased EILV, indicating recruitment of both expiratory and inspiratory muscles. A significant interaction between the effects of exercise and V(D) on mean inspiratory flow indicated that the augmented exercise ventilatory response with added V(D) (i.e. STM) resulted from increased drive to the inspiratory muscles. These results reveal different patterns of respiratory muscle recruitment among experimental conditions. Hence, we conclude that fundamental differences exist in the neural control of ventilatory responses during exercise, increased V(D) and STM.
Wood
Helen E
HE
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center-Dallas, 7232 Greenville Ave., Dallas, TX 75231,USA.
Mitchell
Gordon S
GS
Babb
Tony G
TG
D000328:Adult; D015444:Exercise / Q000502:physiology*; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D010991:Plethysmography / Q000379:methods; D012123:Pulmonary Ventilation / Q000502:physiology*; D012126:Respiratory Dead Space / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology*; D013990:Tidal Volume / Q000502:physiology; D013997:Time Factors