title: Immunotherapy for diabetic amyotrophy.
abstract: BACKGROUND
  People with diabetes mellitus (DM) sometimes present with acute or subacute, progressive, asymmetrical pain and weakness of the proximal lower limb muscles. The various names for the condition include diabetic amyotrophy, or diabetic lumbosacral radiculoplexus neuropathies. Some studies suggest that it may be due to immune-mediated inflammatory microvasculitis causing ischaemic damage of the nerves. Immunotherapies would therefore be expected to be beneficial.
  
  
  OBJECTIVE
  We aimed to review the evidence from randomised trials for the efficacy of any form of immunotherapy in the treatment of diabetic amyotrophy.
  
  
  METHODS
  We searched the Cochrane Neuromuscular Disease Group Trials Register (searched April 2 2009), MEDLINE (searched January 1966 to April 2 2009), EMBASE (searched January 1980 to April 2 2009) and contacted authors of relevant publications and other experts to obtain additional references, unpublished trials, and ongoing trials.
  
  
  METHODS
  We intended to include all randomised and quasi-randomised trials of any immunotherapy in participants with the condition fulfilling all the following: diabetes mellitus as defined by internationally recognised criteria, acute or subacute onset of pain and lower motor neuron weakness involving predominantly the proximal muscles of the lower limbs, weakness that is not confined to one nerve or nerve root distribution and exclusion of other causes of lumbosacral radiculopathies and plexopathy.
  
  
  METHODS
  Two authors independently examined all references retrieved by the search to select those meeting the inclusion criteria.
  
  
  RESULTS
  We found only one completed controlled trial using intravenous methylprednisolone in diabetic amyotrophy (Dyck 2006). The results have not been fully published and were not available for analyses.
  
  
  CONCLUSIONS
  There is presently no evidence from randomised trials to support any recommendation on the use of any immunotherapy treatment in diabetic amyotrophy.
authors: Division of Neurology, National University Hospital, 5, Lower Kent Ridge Road, Singapore, Singapore, 119074.
authors: Yee Cheun
authors: YC
authors: Chan
authors: Yew Long
authors: YL
authors: Lo
authors: Edwin S Y
authors: ES
authors: Chan
mesh_terms: D003929:Diabetic Neuropathies / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*