title: Reduced behavioral effectiveness of ACTH(1-24) after a second administration: interaction with opiates.
abstract: Repeated intraventricular administration of ACHT results in reduction of subsequent ACTH-induced grooming behavior. A previous injection of beta-endorphin, (D-Phe(7))ACTH(4-10), or morphine, also reduces the behavioral response to a subsequent injection of ACTH. The reduction in grooming as a result of repeated administration is not mediated by corticosteroid feedback and can be eliminated by pretreatment with the opiate antagonist naloxone.
authors: Division of Molecular Neurobiology, Rudolf Magnus Institute for Pharmacology, State University of Utrecht, Padualaan 8, Utrecht, The Netherlands.
authors: J
authors: J
authors: Jolles
authors: V M
authors: VM
authors: Wiegant
authors: W H
authors: WH
authors: Gispen