title: Reversibility of acute intermediate phase bilirubin encephalopathy.
abstract: OBJECTIVE
  To show the potential for reversing acute intermediate to advanced phase bilirubin encephalopathy.
  
  
  METHODS
  Case studies.
  
  
  RESULTS
  Six extremely jaundiced infants had symptoms of intermediate to advanced phase acute bilirubin encephalopathy. The infants were treated aggressively. Two patients had brain magnetic resonance imaging showing increased signals in the globus pallidus. On follow-up, all infants are neurologically normal.
  
  
  CONCLUSIONS
  Intermediate-to-advanced stage acute bilirubin encephalopathy may occasionally be reversible. These cases provide a strong argument in favour of rapid and aggressive intervention in infants presenting with extreme jaundice and neurological symptoms.
authors: Neonatal Intensive Care Unit, Division of Paediatrics, Oslo University Hospital, Oslo, Norway. t.w.r.hansen@medisin.uio.no
authors: Thor Willy Ruud
authors: TW
authors: Hansen
authors: Lutz
authors: L
authors: Nietsch
authors: Elisabeth
authors: E
authors: Norman
authors: Jesper Vandborg
authors: JV
authors: Bjerre
authors: Jean-Michel
authors: JM
authors: Hascoet
authors: Khalaf
authors: K
authors: Mreihil
authors: Finn
authors: F
authors: Ebbesen
mesh_terms: D000208:Acute Disease; D001663:Bilirubin / Q000097:blood; D003131:Combined Modality Therapy; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000628:therapy*; D007647:Kernicterus / Q000175:diagnosis / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D010789:Phototherapy
chemical_list: D016756:Immunoglobulins, Intravenous; D001663:Bilirubin