title: Clinical characteristics of laryngeal cancer in BRCA-1 mutation carriers.
abstract: BACKGROUND
  The aim of this study was to analyze the occurrence of clinical features characteristic of breast cancer type 1 susceptibility protein (BRCA-1)-dependent tumors in a series of BRCA-1 mutation carriers with laryngeal cancer.
  
  
  METHODS
  The clinical features of five laryngeal cancer patients with BRCA-1 mutations registered in our center were analyzed for: sex, age at diagnosis, age at operation, tumor size and localization, histopathological subtype and grading, lymph node and distant metastases, mode of treatment and long term results of the therapy.
  
  
  RESULTS
  The five patients were all men, with an average age at diagnosis of 52.4 years. The majority of the patients had clinical features typical of BRCA-1-dependent tumors: four out of the five patients had advanced staging at the time of diagnosis and in three of them the disorder disseminated within one year of follow-up.
  
  
  CONCLUSIONS
  Since laryngeal carcinomas in men with BRCA-1 mutations show clinical features characteristic of BRCA-1 dependent tumors, it is reasonable to consider treatment modifications appropriate for this sub-group of tumors.
authors: Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, 71-252 Szczecin, Poland. jaworowska@tlen.pl
authors: Ewa
authors: E
authors: Jaworowska
authors: Czesława
authors: C
authors: Tarnowska
authors: Jakub
authors: J
authors: Lubiński
authors: Pablo
authors: P
authors: Serrano-Fernández
authors: Tomasz
authors: T
authors: Huzarski
authors: Bogdan
authors: B
authors: Górski
authors: Bartlomiej
authors: B
authors: Masojć
authors: Jerzy
authors: J
authors: Jakubiszyn
authors: Aleksandra
authors: A
authors: Korytowska
authors: Andrzej
authors: A
authors: Kram
authors: Jerzy
authors: J
authors: Rabczynski
authors: Jan
authors: J
authors: Lubiński
mesh_terms: D019398:Genes, BRCA1; D006580:Genetic Carrier Screening; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation