Effects of apomorphine and haloperidol on somatopetal transport of horseradish peroxidase in the nigro-striatal pathway.
Labeling of cell bodies in pars compacta of substantia nigra (SNc) following injections of horseradish peroxidase (HRP) in the neostriatum was not affected by repeated systemic injections of apomorphine or haloperidol during the survival time. These drugs decelerate and accelerate, respectively, the firing of SNc neurons. Provided the used standard method was sensitive enough, it could be concluded that at least in these neurons the somatopetal transport and accumulation of the tracer do not depend on the rate of electrical activity. Consequently, the intensity of labeling with HRP is not a sensitive index of neuronal activity.
Divac
I
I
Laboratory of Behavioral Physiology, Institute of Neurophysiology, University of Copenhagen, Copenhagen Denmark.
Segal
M
M