Cellular efflux of cAMP and cGMP - a question about selectivity.
The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5 (MRP5) and ABCC11 (MRP8) as cellular efflux pumps for cAMP and cGMP. These transporters are potential drug targets for selective modulation of cyclic nucleotide action.
Sager
Georg
G
Faculty of Medicine, Institute of Medical Biology, Department of Pharmacology, University of Tromsø, N- 9037 Tromsø, Norway. georg.sager@fagmed.uit.no
Ravna
Aina Westrheim
AW
D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D013379:Substrate Specificity
D018528:ATP-Binding Cassette Transporters; D000242:Cyclic AMP; D006152:Cyclic GMP