title: Steroid-induced intraocular pressure elevation or glaucoma after penetrating keratoplasty in patients with keratoconus or Fuchs dystrophy.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the frequency of steroid-induced intraocular pressure (IOP) elevation and/or glaucoma in patients with keratoconus (KCN) compared with patients with Fuchs endothelial dystrophy after penetrating keratoplasty (PK).
  
  
  METHODS
  A retrospective review of the medical records of patients with KCN or Fuchs dystrophy, who underwent PK and were examined on the Cornea Service, Wills Eye Institute, was performed. IOP measurements were recorded preoperatively; postoperative first month and maximal IOP measurements between 1 and 3 months, 4 and 6 months, 7 and 12 months, 1 and 2 years, 2 and 3 years, and 3 and 4 years were noted. Steroid-induced IOP elevation and/or glaucoma were grouped into 5 different categories; an increase in IOP of at least 5 or 10 mm Hg over the preoperative baseline and also IOP > or =22, 30, and 40 mm Hg. Addition of glaucoma medications and/or characteristic glaucomatous optic disc and visual field changes were also assessed.
  
  
  RESULTS
  A total of 100 patients with KCN and 58 patients with Fuchs dystrophy were included in this study. The overall frequency of steroid-induced IOP elevation after PK was 73% in the KCN group and 60.3% in the Fuchs dystrophy group. The frequency of IOP elevation of at least 5 or 10 mm Hg over the preoperative baseline were 72% and 24% in KCN group and 56.9% and 20.7% in the Fuchs dystrophy group, respectively. The frequency of IOP elevation > or =22 or > or =30 mm Hg was 22% and 6% in the KCN group and 29.3% and 1.7% in the Fuchs dystrophy group, respectively. There was one patient in the KCN group who had IOP >40 mm Hg. There was no difference between the groups in terms of frequency of IOP elevation (P > 0.05 for all). Glaucomatous visual field defect was detected in 4 patients in the KCN group and only one patient in the Fuchs dystrophy group. Despite the maximum medical therapy, 2 patients in the KCN group underwent glaucoma surgery and none in the Fuchs dystrophy group.
  
  
  CONCLUSIONS
  Steroid-induced IOP elevation or glaucoma after PK is not unusual in eyes with KCN or Fuchs dystrophy. Careful and ongoing observation of IOP throughout the prolonged follow-up period is recommended for these individuals with prompt attention to IOP treatment as indicated.
authors: Cornea Service, Wills Eye Institute, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors: Mesut
authors: M
authors: Erdurmus
authors: Elisabeth J
authors: EJ
authors: Cohen
authors: Elvin H
authors: EH
authors: Yildiz
authors: Kristin M
authors: KM
authors: Hammersmith
authors: Peter R
authors: PR
authors: Laibson
authors: David
authors: D
authors: Varssano
authors: Christopher J
authors: CJ
authors: Rapuano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000730:Androstadienes / Q000009:adverse effects; D005260:Female; D005469:Fluorometholone / Q000009:adverse effects; D005642:Fuchs' Endothelial Dystrophy / Q000601:surgery*; D005901:Glaucoma / Q000139:chemically induced*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007640:Keratoconus / Q000601:surgery*; D015948:Keratoplasty, Penetrating; D000069559:Loteprednol Etabonate; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000139:chemically induced; D011239:Prednisolone / Q000009:adverse effects / Q000031:analogs & derivatives; D012189:Retrospective Studies; D012307:Risk Factors; D014065:Tonometry, Ocular; D055815:Young Adult
chemical_list: D000730:Androstadienes; D005938:Glucocorticoids; C009022:prednisolone phosphate; C009935:prednisolone acetate; D011239:Prednisolone; D005469:Fluorometholone; D000069559:Loteprednol Etabonate