title: Prevalence of impaired fasting glucose and analysis of risk factors in Han adolescents.
abstract: OBJECTIVE
  To evaluate the prevalence of impaired fasting glucose (IFG) and its relationship with cardiovascular risk factors in Han adolescents aged 13 to 18 years.
  
  
  METHODS
  Step 1: A cross-sectional study was conducted on 3937 Han adolescents. IFG was defined as a fasting glucose of 5.6 to 7.0 mmol/l. Measurements included anthropometric measurements, fasting plasma glucose (FPG), and serum lipids. Step 2: We identified 60 adolescents with IFG from the IFG group using a random number table, and 60 adolescents with normal fasting glucose (NFG) were matched for age and gender with the random IFG sample. Serum true insulin (TI) was further measured.
  
  
  RESULTS
  (1) The prevalence of IFG was 3.5% and was similar in boys and girls (3.9% vs. 3.1%, P=.177). The prevalence of IFG in adolescents with a family history of type 2 diabetes (FHD) was higher than in adolescents without FHD (6.3% vs. 2.5%, P=.000). (2) In logistic regression, the clustering of cardiovascular risk factors among adolescents with IFG was 1.889 (95% CI: 1.125-3.171, P=.016) times compared with adolescents with NFG adjusted by age and gender. (3) Multiple linear regression analysis using FPG as the dependent variable showed that waist circumference (beta=0.003, P=.000) was a significant independent predictor. (4) In Step 2, the IFG group showed significantly higher levels of lnTI and lnHOMA-IR than the NFG group (P<.01). FPG was a significant independent predictor for lnTI (beta=0.478, P=.000) and lnHOMA-IR (beta=0.671, P=.000).
  
  
  CONCLUSIONS
  We found a high prevalence of IFG in Han adolescents. Genetic susceptibility and abdominal obesity were the main factors causing adolescent IFG. Adolescents with IFG increased the clustering of cardiovascular risk factors.
authors: Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China.
authors: Qiang
authors: Q
authors: Lu
authors: Fu-Zai
authors: FZ
authors: Yin
authors: Chun-Ming
authors: CM
authors: Ma
authors: Bo-Wei
authors: BW
authors: Liu
authors: Dong-Hui
authors: DH
authors: Lou
authors: Rui
authors: R
authors: Wang
authors: Guang-Fei
authors: GF
authors: Wu
authors: Gai-Ling
authors: GL
authors: Han
authors: Yi
authors: Y
authors: Shen
authors: Bo
authors: B
authors: Liu
authors: Chun-Mei
authors: CM
authors: Qin
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000706:statistics & numerical data; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids