title: Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol.
abstract: A series of honokiol analogues were synthesized by modifying the 5- and/or 3'-position(s) of honokiol to assess their anti-tumor effects. Some compounds exerted more potent anti-proliferative activities than those of honokiol on K562 leukemia cells, A549 alveolar basal epithelial cells, SPC-A1 adenocarcinoma cells and A2780 human ovarian carcinoma cells in vitro. Compounds 2b, 3a, and 3c displayed most potent anti-proliferative activities against these tested cell strains and their anti-drug resistance effects were evaluated in vitro on cisplatin-resistant A2780 human ovarian carcinoma cells. The structure-activity relationship was also proposed.
authors: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors: Youfu
authors: Y
authors: Luo
authors: Yongbin
authors: Y
authors: Xu
authors: Lijuan
authors: L
authors: Chen
authors: Jia
authors: J
authors: Hu
authors: Cheng
authors: C
authors: Peng
authors: DaChun
authors: D
authors: Xie
authors: Jianyou
authors: J
authors: Shi
authors: Wencai
authors: W
authors: Huang
authors: Guobin
authors: G
authors: Xu
authors: Ming
authors: M
authors: Peng
authors: Jing
authors: J
authors: Han
authors: Rui
authors: R
authors: Li
authors: Shengyong
authors: S
authors: Yang
authors: Yuquan
authors: Y
authors: Wei
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D017705:Lignans; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols