title: Does glomerular hyperfiltration in pregnancy damage the kidney in women with more parities?
abstract: OBJECTIVE
  We aimed to investigate the glomerular hyperfiltration due to pregnancy in women with more parities.
  
  
  METHODS
  Five hundred women aged 52.57 +/- 8.08 years, without a history of hypertension, diabetes mellitus or complicated pregnancy were involved in the study. They were divided into three groups. Group 1: women with no or one parity (n = 76); group 2: women with two or three parities (n = 333); group 3: women with four or more parities (n = 91). Laboratory parameters and demographical data were compared between the three groups.
  
  
  RESULTS
  Mean age, serum urea and serum creatinine were similar between three groups. Patients in group 3 had significantly higher GFR values compared to groups 1 and 2 (109.44 +/- 30.99, 110.76 +/- 30.22 and 121.92 +/- 34.73 mL/min/1.73 m(2) for groups 1, 2 and 3, respectively; P = 0.008 for group 1 vs group 3; P = 0.002 for group 2 vs group 3).
  
  
  CONCLUSIONS
  In our study, we suggest that glomerular hyperfiltration due to pregnancy does not have adverse effects on kidney in women with more parities. Pregnancy may have possible protective mechanisms for kidney against adverse effects of glomerular hyperfiltration.
authors: Department of Obstetrics and Gynecology, Fatih University School of Medicine, Ankara, Turkey.
authors: Ilknur Inegol
authors: II
authors: Gumus
authors: Ebru
authors: E
authors: Uz
authors: Nuket
authors: N
authors: Bavbek
authors: Ayse
authors: A
authors: Kargili
authors: Burcu
authors: B
authors: Yanik
authors: Faruk Hilmi
authors: FH
authors: Turgut
authors: Ali
authors: A
authors: Akcay
authors: Nilgun Ozturk
authors: NO
authors: Turhan
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015992:Body Mass Index; D015331:Cohort Studies; D016001:Confidence Intervals; D003404:Creatinine / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D007677:Kidney Function Tests; D008875:Middle Aged; D010298:Parity; D011247:Pregnancy / Q000502:physiology*; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000453:epidemiology*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014508:Urea / Q000652:urine; D014527:Uric Acid / Q000652:urine; D016482:Urinalysis
chemical_list: D014527:Uric Acid; D014508:Urea; D003404:Creatinine