title: Incidence and outcome of acquisition of human papillomavirus infection in women with normal cytology--a population-based cohort study from Taiwan.
abstract: Little is known about acquisition of human papillomavirus (HPV) and its outcome among older women with negative HPV testing and normal cytology. A longitudinal 3-yr follow-up of nested-cohort subjects (n = 8825) from a population-based cervical cancer screening study whose Pap and HPV tests were negative at baseline were conducted. Every active HPV-negative (n = 413) participant had 12-mo follow-ups of Pap smear and HPV testing. Colposcopy was performed if either HPV-positive or cytology was abnormal. The cytology and histology information of the remaining subjects (passive HPV-negative, n = 8412) was obtained from national registry database. Median age of participants was 45 yr (range, 30-73 yr). The incidence of new acquisition was 4.2/100 woman-years. The 3-yr cumulative total HPV acquisition rate was 11.1% (95% confidence interval [CI]: 8.1-14.1). Increased number of sexual partners (> or =2 vs. 1) of the participant was associated with risk of acquisition (odds ratio [OR]: 5.0, 95% CI: 2.0-12.6) by multivariate analysis. Three cases of > or = cervical intraepithelial neoplasia (CIN) 2 were identified in 3-yr follow-up in active HPV-negative subjects. HPV genotypes in the dysplastic tissue were actually present at baseline samples after reanalysis. From the passive HPV-negative group, only 1 case progressed to CIN2 probably after HPV acquisition. Negative Pap and HPV tests assured a very low risk of developing > or = CIN2 within 3 yr despite incident HPV infection.
authors: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
authors: Angel
authors: A
authors: Chao
authors: Chee-Jen
authors: CJ
authors: Chang
authors: Chyong-Huey
authors: CH
authors: Lai
authors: Fang-Yu
authors: FY
authors: Chao
authors: Yi-Hsien
authors: YH
authors: Hsu
authors: Hung-Hsueh
authors: HH
authors: Chou
authors: Huei-Jean
authors: HJ
authors: Huang
authors: Shih-Ming
authors: SM
authors: Jung
authors: Cheng-Tao
authors: CT
authors: Lin
authors: Hui-Hsin
authors: HH
authors: Cheng
authors: Chu-Chun
authors: CC
authors: Huang
authors: Jung-Erh
authors: JE
authors: Yang
authors: Ting-Chang
authors: TC
authors: Chang
mesh_terms: D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000235:genetics; D015331:Cohort Studies; D003127:Colposcopy; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology*; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D012042:Registries; D013624:Taiwan