title: [Black bone disease of the skull and facial bones].
abstract: BACKGROUND
  We report the case of a patient with a craniofacial black bone disease. This was discovered accidentally during a coronal approach.
  
  
  METHODS
  A 38-year-old patient was referred to our unit for facial palsy having appeared 10 years before. Rehabilitation of the facial palsy was performed with a lengthening temporal myoplasty and lengthening of the upper eyelid elevator. An unusual black color of the skull was observed at incision of the coronal approach. Subperiostal dissection of skull and malars confirmed the presence of a black bone disease. A postoperative history revealed minocycline intake (200mg per day) during 3 years.
  
  
  CONCLUSIONS
  This craniofacial black bone disease was caused by minocycline intake. The originality of this case is to see directly the entire craniofacial skeleton black. This abnormal pigmentation may affect various organs or tissues. Bone pigmentation is irreversible unlike that of the mouth mucosa or of the skin. This abnormal pigmentation is usually discovered accidentally.
authors: Service de chirurgie maxillofaciale et plastique de la face, CHU Trousseau, route de Loche, 37044 Tours cedex, France. laure@med.univ-tours.fr
authors: B
authors: B
authors: Laure
authors: A
authors: A
authors: Petraud
authors: F
authors: F
authors: Sury
authors: J-C
authors: JC
authors: Bayol
authors: N
authors: N
authors: Marquet-Van Der Mee
authors: G
authors: G
authors: de Pinieux
authors: D
authors: D
authors: Goga
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001847:Bone Diseases / Q000139:chemically induced*; D005147:Facial Bones / Q000473:pathology; D006801:Humans; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced*; D012886:Skull / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline