Detection of tolerance against human chorionic gonadotropin at malignant and benign tumors of female reproduction system.
The main aim of this study was to investigate the possibility of hCG synthesis during malignant gynecological tumors and establish the level of tolerance against hCG in malignant and benign tumors. We have examined peripheral blood of 86 patients with malignant and benign tumors of reproductive system and healthy donors, aged 42-65 for detection of anti-hCG auto-antibodies and possibility of hCG synthesis. Investigation have shown that in case of malignant tumors as auto-antibody concentration is low and hCG level is high, hCG plays a role of autocrine growth factor for tumor cells and maintains the malignancy and tumor growth. The existence of auto-antibody indicates that immune system is not completely tolerant to hCG. During studies on the effectiveness of anti-tumor vaccine, this fact should be taken into consideration.
Akhvlediani
L
L
Sh. Rustaveli Batumi State University.
Nagervadze
M
M
Dumbadze
G
G
D000328:Adult; D000912:Antibodies, Neoplasm / Q000032:analysis / Q000276:immunology*; D006063:Chorionic Gonadotropin / Q000276:immunology*; D005260:Female; D005833:Genital Neoplasms, Female / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008875:Middle Aged
D000912:Antibodies, Neoplasm; D006063:Chorionic Gonadotropin