Anidulafungin in combination with amphotericin B against Aspergillus fumigatus.
We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.
Spreghini
Elisabetta
E
Dipartimento di Scienze Biomediche, Clinica di Malattie Infettive, Università Politecnica delle Marche, Ancona, Italy.
Orlando
Fiorenza
F
Santinelli
Alfredo
A
Pisa
Eleonora
E
Loretelli
Cristian
C
Manso
Esther
E
Milici
Maria Eleonara
ME
Scalise
Giorgio
G
Barchiesi
Francesco
F
D000666:Amphotericin B / Q000494:pharmacology*; D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy / Q000401:mortality; D001232:Aspergillus fumigatus / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D054714:Echinocandins; D000666:Amphotericin B; D000077612:Anidulafungin