[Ejaculatory disorder caused by doxazosin administration for blood pressure control in patient with pheochomocytoma].
A 29-year-old man had been treated for hypertension for 10 years. He suffered from speech disturbance caused by cerebral infarction, and further examinations were performed. Computerized tomography scan and magnetic resonance imaging revealed a left adrenal tumor 6 cm in size. The radioisotope (MIBG) accumulated in the left adrenal gland. The serum noradrenalin levels were high. Thus, the diagnosis of pheochomocytoma in left adrenal tumor was made. He noticed ejaculation disturbance 5 days after starting administration of doxazosin at the dose of 3 mg/day for pre-operative blood pressure control. Sperm was observed in the urine sampling obtained after masturbation, thus his ejaculation disturbance was considered to be retrograde ejaculation. Laparoscopic left adrenalectomy was performed. After the operation, his blood pressure normalized and the administration of doxazosin has not been necessary. He could perform ejaculation without any trouble after stopping doxazosin intake. The bladder neck conditions measured by ultrasonography were the same before and after the administration of doxazosin. The present case is a very rare case of ejaculation disturbance caused by non-selective alpha 1 blocker doxazosin.
Amano
Toshiyasu
T
Department of Urology, Nagano Red Cross Hospital.
Imao
Tetsuya
T
Takemae
Katsuro
K
Yamauchi
Keishi
K
D000310:Adrenal Gland Neoplasms / Q000150:complications*; D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects*; D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects*; D017292:Doxazosin / Q000009:adverse effects*; D004542:Ejaculation / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D008297:Male; D010673:Pheochromocytoma / Q000150:complications*; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced*
D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D017292:Doxazosin