title: Synthesis of fully substituted pyrazoles via regio- and chemoselective metalations.
abstract: The full functionalization of the pyrazole ring was achieved by successive regioselective metalations using TMPMgCl x LiCl and TMP(2)Mg x 2 LiCl. Trapping with various electrophiles led to trisubstituted pyrazoles. An application to the synthesis of the acaricide Tebufenpyrad is reported.
authors: Department Chemie & Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München, Germany.
authors: Christina
authors: C
authors: Despotopoulou
authors: Lydia
authors: L
authors: Klier
authors: Paul
authors: P
authors: Knochel
mesh_terms: D009942:Organometallic Compounds / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D011720:Pyrazoles; C530465:TMPMgCl.LiCl