Clinical manifestation of mannose-binding lectin deficiency in adults independent of concomitant immunodeficiency.
Mannose-binding lectin (MBL) mediates important functions within the innate immune system, and its deficiency was associated with infectious complications. However, in adults without concomitant immunodeficiency the clinical relevance of MBL deficiency remains controversial. We analyzed the distribution of MBL deficiency and its association with concomitant immunodeficiency in 228 adult Caucasian patients with a history of recurrent and/or severe infections. Two hundred forty-one unrelated Caucasians without recurrent or severe infections served as control subjects. The frequency of severe MBL deficiency (plasma levels <or= 50 ng/ml) was significantly higher in patients with a history of recurrent and/or severe infections (p < 0.05, odds ratio 2.1, 95% confidence interval 1.1-4.1), and this association was independent of concomitant antibody or cellular immunodeficiency. Our data challenge the view that MBL deficiency in adulthood becomes relevant only in individuals who are immunocompromised for other reasons.
Hoeflich
Conny
C
Institute of Medical Immunology, University Hospital Charité, Berlin, Germany.
Unterwalder
Nadine
N
Schuett
Sabine
S
Schmolke
Kathrin
K
Boenisch
Olaf
O
Hammer
Markus
M
Scheufele
Ramona
R
Michael
Dagmar
D
Volk
Hans-Dieter
HD
Scheibenbogen
Carmen
C
von Baehr
Volker
V
Meisel
Christian
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*; D007239:Infections / Q000097:blood / Q000276:immunology; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood / Q000172:deficiency*; D008875:Middle Aged; D015995:Prevalence; D012008:Recurrence; D012189:Retrospective Studies; D055815:Young Adult
D037601:Mannose-Binding Lectin