Intra-arterial delivery of triolein emulsion increases vascular permeability in skeletal muscles of rabbits.
BACKGROUND
To test the hypothesis that triolein emulsion will increase vascular permeability of skeletal muscle.


METHODS
Triolein emulsion was infused into the superficial femoral artery in rabbits (triolein group, n = 12). As a control, saline was infused (saline group, n = 18). Pre- and post-contrast T1-weighted MR images were obtained two hours after infusion. The MR images were qualitatively and quantitatively evaluated by assessing the contrast enhancement of the ipsilateral muscles. Histologic examination was performed in all rabbits.


RESULTS
The ipsilateral muscles of the rabbits in the triolein group showed contrast enhancement, as opposed to in the ipsilateral muscles of the rabbits in the saline group. The contrast enhancement of the lesions was statistically significant (p < 0.001). Histologic findings showed that most examination areas of the triolein and saline groups had a normal appearance.


CONCLUSIONS
Rabbit thigh muscle revealed significantly increased vascular permeability with triolein emulsion; this was clearly demonstrated on the postcontrast MR images.
Kim
Hak Jin
HJ
The Department of Radiology, Pusan National University College of Medicine, Medical Research Institute, Pusan National University, Pusan, South Korea. hakjink@pusan.ac.kr
Kim
Yong Woo
YW
Lee
In Sook
IS
Song
Jong Woon
JW
Jeong
Yeon Joo
YJ
Choi
Seon Hee
SH
Choi
Kyung Un
KU
Suh
Kuen Tak
KT
Cho
Byung Mann
BM
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D003287:Contrast Media; D004655:Emulsions; D007089:Image Enhancement; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging / Q000379:methods; D018482:Muscle, Skeletal / Q000098:blood supply*; D011817:Rabbits; D011897:Random Allocation; D012039:Regional Blood Flow; D014304:Triolein / Q000493:pharmacokinetics*
D003287:Contrast Media; D004655:Emulsions; D014304:Triolein