title: Ischemic tolerance in the cochlea.
abstract: Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single ischemia group and double ischemia group. In the single ischemia group, animals were subjected to lethal cochlear ischemia for 15 min. In the double ischemia group, animals were subjected to sublethal cochlear ischemia for 2 min at 2 days before lethal ischemia for 15 min. Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea.
authors: Department of Otolaryngology, Ehime University Graduate School of Medicine, Shitsukawa, Ehime, Japan.
authors: Shoichiro
authors: S
authors: Takeda
authors: Ryuji
authors: R
authors: Hata
authors: Fang
authors: F
authors: Cao
authors: Tadashi
authors: T
authors: Yoshida
authors: Nobuhiro
authors: N
authors: Hakuba
authors: Naohito
authors: N
authors: Hato
authors: Kiyofumi
authors: K
authors: Gyo
mesh_terms: D000818:Animals; D003051:Cochlea / Q000098:blood supply*; D005849:Gerbillinae; D006199:Hair Cells, Auditory, Inner / Q000473:pathology; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000517:prevention & control; D007511:Ischemia / Q000150:complications / Q000473:pathology* / Q000517:prevention & control; D019194:Ischemic Preconditioning; D008297:Male