N-heterocyclic carbene-catalyzed cross-coupling of aldehydes with arylsulfonyl indoles.
3-(1-Arylsulfonylalkyl)indoles as electrophiles in the N-heterocyclic carbene-catalyzed umpolung reaction of aldehydes were realized for the first time. This intermolecular Stetter-type reaction features the commercially available catalyst and mild reaction conditions, providing alpha-(3-indolyl) ketone derivatives in high yields for a wide range of substrates.
Li
Yi
Y
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Shi
Fu-Qiang
FQ
He
Qing-Li
QL
You
Shu-Li
SL