title: Variation in the safety of induced pluripotent stem cell lines.
abstract: We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells.
authors: Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
authors: Kyoko
authors: K
authors: Miura
authors: Yohei
authors: Y
authors: Okada
authors: Takashi
authors: T
authors: Aoi
authors: Aki
authors: A
authors: Okada
authors: Kazutoshi
authors: K
authors: Takahashi
authors: Keisuke
authors: K
authors: Okita
authors: Masato
authors: M
authors: Nakagawa
authors: Michiyo
authors: M
authors: Koyanagi
authors: Koji
authors: K
authors: Tanabe
authors: Mari
authors: M
authors: Ohnuki
authors: Daisuke
authors: D
authors: Ogawa
authors: Eiji
authors: E
authors: Ikeda
authors: Hideyuki
authors: H
authors: Okano
authors: Shinya
authors: S
authors: Yamanaka
mesh_terms: D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D051379:Mice; D009474:Neurons / Q000166:cytology; D039904:Pluripotent Stem Cells / Q000166:cytology*; D012449:Safety; D013724:Teratoma / Q000473:pathology