Fibrinolytic compounds isolated from a brown alga, Sargassum fulvellum.
Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(alpha-D-glucopyranosyl)-glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(alpha-D-glucopyranosyl)-glycerol (MOGG) which were obtained from Sargassum fulvellum for the first time. POGG and MOGG showed fibrinolytic activity in the reaction system of pro-u-PA and plasminogen.
Wu
Wenhui
W
Department of Marine Biopharmacology, Shanghai Ocean University, Shanghai 201306, P.R. China. whwu@shou.edu.cn
Hasumi
Keiji
K
Peng
Hui
H
Hu
Xianwen
X
Wang
Xichang
X
Bao
Bin
B
D004075:Diglycerides / Q000737:chemistry* / Q000302:isolation & purification*; D005343:Fibrinolytic Agents / Q000737:chemistry* / Q000302:isolation & purification*; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D044647:Sargassum / Q000737:chemistry*
D004075:Diglycerides; D005343:Fibrinolytic Agents