Controlled release of dual drugs from emulsion electrospun nanofibrous mats.
The purpose of this work is to develop a novel type of tissue engineering scaffold or drugs delivery carrier with the capability of encapsulation and controlled release drugs. In this study, Rhodamine B and Bovine Serum Albumin (BSA) were successfully incorporated into nanofibers by means of emulsion electrospinning. The morphology of composite nanofibers was studied by Scanning Electron Microscopy (SEM). The composite nanofibrous mats made from emulsion electrospinning were characterized by water contact angle measurement and X-ray diffraction. In vitro dual drugs release behaviors from composite nanofibrous mats were investigated. The results indicated that the incorporated drug and/or proteins in composite fibrous mats made from electrospinning could be control released by adjusting the processes of emulsions preparation.
Yan
Su
S
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, China.
Xiaoqiang
Li
L
Shuiping
Liu
L
Xiumei
Mo
M
Ramakrishna
Seeram
S
D000818:Animals; D032701:Biomimetics; D002417:Cattle; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004655:Emulsions; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry; D012235:Rhodamines / Q000032:analysis / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000032:analysis / Q000737:chemistry; D012996:Solutions; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D003692:Delayed-Action Preparations; D004655:Emulsions; D011091:Polyesters; D012235:Rhodamines; D012996:Solutions; D014867:Water; D012710:Serum Albumin, Bovine; C062968:lactide-caprolactone copolymer; C029773:rhodamine B