Seroprevalence of Helicobacter pylori in patients with colon adenomas in a Brazilian university hospital.
BACKGROUND
The association between Helicobacter pylori infection and colon neoplasia has been the subject of recent investigations which have produced controversial results.


OBJECTIVE
To evaluate the prevalence of H. pylori infection in patients with colonic adenomas and also in patients whose colonoscopy exams were normal.


METHODS
After colonoscopy, the individuals were distributed into two groups: patients with colon adenomas (cases) and patients whose colons were normal (controls). The groups were similar regarding age and gender. The individuals of both groups were subjected to a dosage of IgG antibody against H. pylori. The dosage was applied according to the solid phase, chemiluminescent immunometric assay. The chi-square test was used to analyze the data.


RESULTS
There were 30 men and 64 women in each group (94 cases and 94 controls). The mean age of the cases was 59.79 +/- 12.25 years and that of the controls was 58.98 +/- 11.55 years. The H. pylori serology was positive for 66 (70.21%) of the cases and for 51 (54.25%) of the controls. There was a significant difference (P = 0.024). The odds ratio was 1.98 (CI 95%, 0.82-3.15). The prevalence of H. pylori in cases and controls according to gender, histological type and location of the colon lesions showed a significant difference only among women (P = 0.03), among patients with tubular adenomas (P = 0.03), and in those with distal adenomas (P = 0.038).


CONCLUSIONS
There is a positive association between H. pylori infection and colonic adenomas. This association is more evident in women, especially for tubular adenomas and distal colonic location.
Buso
Abadia Gilda
AG
Gastroenterology Unit, Hospital das Clínicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. agbuso@yahoo.com.br
Rocha
Haroldo Luis Oliva Gomes
HL
Diogo
Débora Miranda
DM
Diogo
Priscila Miranda
PM
Diogo-Filho
Augusto
A
D000236:Adenoma / Q000382:microbiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood; D015415:Biomarkers; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000382:microbiology*; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology; D006785:Hospitals, University; D006801:Humans; D007118:Immunoassay; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016036:Seroepidemiologic Studies; D055815:Young Adult
D000907:Antibodies, Bacterial; D015415:Biomarkers; D007074:Immunoglobulin G