title: Cost-effectiveness of colorectal cancer screening with computed tomography colonography according to a polyp size threshold for polypectomy.
abstract: OBJECTIVE
  Computed tomography colonography (CTC) has an acceptable accuracy in detecting colonic lesions, especially for polyps at least 6 mm. The aim of this analysis is to determine the cost-effectiveness of population-based screening for colorectal cancer (CRC) using CTC with a polyp size threshold.
  
  
  METHODS
  The cost-effectiveness ratios of CTC performed at 50, 60 and 70 years old, without (PL strategy) or with (TS strategy) polyp size threshold were compared using a Markov process. Incremental cost-effectiveness ratios (ICER) were calculated per life-years gained (LYG) for a time horizon of 30 years.
  
  
  RESULTS
  The ICER of PL and TS strategies were 12 042 and 2765 euro/LYG associated to CRC prevention rates of 37.9 and 36.5%. The ICER of PL and TS strategies dropped to 9687 and 1857 euro/LYG when advanced adenoma (AA) prevalence increased from 6.9 to 8.6% for male participants and 3.8-4.9% for female participants or to 9482 and 2067 euro/LYG when adenoma and AA annual recurrence rates dropped to 3.2 and 0.25%. The ICER for PL and TS strategies decreased to 7947 and 954 euro/LYG or when only two CTC were performed at 50 and 60-years-old. Conversely, the ICER did not significantly change when varying population participation rate or accuracy of CTC.
  
  
  CONCLUSIONS
  CTC with a 6 mm threshold for polypectomy is associated to a substantial cost reduction without significant loss of efficacy. Cost-effectiveness depends more on the AA prevalence or transition rate to CRC than on CTC accuracy or screening compliance.
authors: Department of Gastroenterology, University Hospital of Rennes, France. denis.heresbach@chu-rennes.fr
authors: Denis
authors: D
authors: Heresbach
authors: Pauline
authors: P
authors: Chauvin
authors: Aurélie
authors: A
authors: Hess-Migliorretti
authors: Françoise
authors: F
authors: Riou
authors: Jacques
authors: J
authors: Grolier
authors: Jean-Michel
authors: JM
authors: Josselin
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000453:epidemiology; D000368:Aged; D003111:Colonic Polyps / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000601:surgery; D023881:Colonography, Computed Tomographic / Q000191:economics*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology; D003362:Cost-Benefit Analysis; D055088:Early Detection of Cancer / Q000191:economics*; D005260:Female; D005602:France; D017048:Health Care Costs; D006801:Humans; D008297:Male; D008390:Markov Chains; D008875:Middle Aged; D015995:Prevalence; D012008:Recurrence