Inhibition of the noradrenergic induction of pineal N-acetyltransferase by dibutyryl cyclic guanosine monophosphate and by ionophore X-537A.
Utilizing rat pineals in vitro, it can be demonstrated that dibutyryl cyclic GMP and the calcium ionophore X-537A are both able to reversibly inhibit the elevation of pineal N-acetyltransferase induced by the beta-agonists norepinephrine or isoproterenol. These results are discussed in terms of the known hyposensitivy of the pineal gland to overstimulation by beta-agonists.
Wilkinson
M
M
Département de Physiologie, Ecole de Médecine, Université de Genève, 1211 Genève 4, Switzerland.