Angiomatous reaction Kaposi-sarcoma-like as a side effect of topical corticosteroid therapy in lichen sclerosus of the penis.
Lichen sclerosus (LS) is a chronic inflammatory skin condition usually located in the anogenital area. Topical corticosteroid therapy is the first choice treatment which may arrest or delay the progression of the disorder. We report the case of a 74-year-old man presented with a 6-month history of nodular lesions localized on penis. The man had a previous history of genital lesions that had been diagnosed as LS and treated with long-term topical corticosteroid therapy. After 3 months of corticosteroid therapy, the patient observed the appearance of several nodular erythematous lesions on the penis with progressive disappearance of the clinical symptoms of LS. These purple to red asymptomatic angiomatoid nodules resembled the clinical features of Kaposi sarcoma.
Catricalà
Caterina
C
Department of Dermatology-Oncology, S. Gallicano Institute, IRCCS, Rome, Italy. catricala@ifo.it
Marenda
Samantha
S
Muscardin
Luca Maria
LM
Donati
Pietro
P
Lepri
Andrea
A
Eibenschutz
Laura
L
D000368:Aged; D002990:Clobetasol / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010409:Penile Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D010413:Penis / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000175:diagnosis / Q000473:pathology
D005938:Glucocorticoids; C010893:clobetasone butyrate; D002990:Clobetasol