title: Peroxiredoxin II preserves cognitive function against age-linked hippocampal oxidative damage.
abstract: Reactive oxygen species (ROS), routinely produced in biological reactions, contribute to both normal aging and age-related decline in cognitive function. However, little is known regarding the involvement of specific antioxidants in the underlying mechanism(s). Here, we examined if peroxiredoxin II (Prx II) scavenges intracellular ROS that cause age-dependent mitochondrial decay in hippocampal CA1 pyramidal neurons and subsequent impairment of learning and memory. Age-dependent mitochondrial ROS generation and long-term potentiation (LTP) decline were more prominent in hippocampal neurons in Prx II(-/-) than in wild-type mice. Additionally, Prx II(-/-) mice failed to activate synaptic plasticity-related cellular signaling pathways involving CREB, CaMKII, and ERK, or to maintain functional integrity of their mitochondria. Dietary vitamin E alleviated Prx II deficiency-related deficits, including mitochondrial decay and CREB signaling, resulting in restoration of the abrupt cognitive decline in aged Prx II(-/-) mice. These results suggest that Prx II help maintain hippocampal synaptic plasticity against age-related oxidative damage.
authors: Aging Science Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Republic of Korea.
authors: Sun-Uk
authors: SU
authors: Kim
authors: Mei-Hua
authors: MH
authors: Jin
authors: Yoon Sik
authors: YS
authors: Kim
authors: Sang-Hee
authors: SH
authors: Lee
authors: Yee Sook
authors: YS
authors: Cho
authors: Kyoung-Joo
authors: KJ
authors: Cho
authors: Kyu-Sun
authors: KS
authors: Lee
authors: Yang In
authors: YI
authors: Kim
authors: Gyung Whan
authors: GW
authors: Kim
authors: Jin-Man
authors: JM
authors: Kim
authors: Tae-Hoon
authors: TH
authors: Lee
authors: Young-Ho
authors: YH
authors: Lee
authors: Minho
authors: M
authors: Shong
authors: Hyung-Chun
authors: HC
authors: Kim
authors: Kyu-Tae
authors: KT
authors: Chang
authors: Dae-Yeul
authors: DY
authors: Yu
authors: Dong-Seok
authors: DS
authors: Lee
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D001522:Behavior, Animal; D050882:CREB-Binding Protein / Q000235:genetics / Q000378:metabolism; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects / Q000235:genetics; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology*; D007859:Learning Disabilities / Q000178:diet therapy / Q000235:genetics; D017774:Long-Term Potentiation / Q000187:drug effects / Q000235:genetics; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008928:Mitochondria / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D054464:Peroxiredoxins / Q000172:deficiency / Q000378:metabolism*; D050050:Protein Carbonylation / Q000187:drug effects; D017382:Reactive Oxygen Species; D014810:Vitamin E / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D014810:Vitamin E; D008315:Malondialdehyde; D054464:Peroxiredoxins; D050882:CREB-Binding Protein; D017868:Cyclic AMP-Dependent Protein Kinases; D048049:Extracellular Signal-Regulated MAP Kinases