Aberrant expression of CD8 in B-cell non-Hodgkin lymphoma: a multicenter study of 951 bone marrow samples with lymphomatous infiltration.
T-cell antigen expression can be observed in B-cell non-Hodgkin lymphoma (B-NHL). Although CD5 is expressed in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma, the presence of other T-cell antigens is less common. This article reports a retrospective multicenter analysis in which flow cytometry was used to evaluate aberrant CD8 expression on the pathologic B cells of 951 bone marrow samples from patients with various types of B-NHL. In a total of 18 patients, CD8 was coexpressed: 10 had B-CLL; 1, small lymphocytic lymphoma (SLL); 1, marginal zone lymphoma; 1, lymphoplasmacytic lymphoma; 2, diffuse large B-cell lymphoma; and 3, follicular lymphoma. There was a 1.89% overall frequency of CD8 coexpression in which B-CLL/SLL had a higher frequency (3.03%) than did the other B-cell neoplasms (1.18%). Most cases were characterized by a favorable outcome.
Carulli
Giovanni
G
Division of Hematology, and Flow Cytometry Section, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Santa Chiara Hospital, Via Roma 67, Pisa 56126, Italy.
Stacchini
Alessandra
A
Marini
Alessandra
A
Ciriello
Maria Matilde
MM
Zucca
Alessandra
A
Cannizzo
Elisa
E
Aliberti
Sabrina
S
Demurtas
Anna
A
Novero
Domenico
D
Calcagno
Lara
L
Callegari
Tiziana
T
Petrini
Mario
M
D018941:Antigens, CD19 / Q000096:biosynthesis; D014408:Biomarkers, Tumor / Q000032:analysis*; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D018956:CD5 Antigens / Q000096:biosynthesis; D016827:CD8 Antigens / Q000096:biosynthesis*; D005434:Flow Cytometry; D006801:Humans; D016393:Lymphoma, B-Cell / Q000378:metabolism* / Q000473:pathology*; D012189:Retrospective Studies
D018941:Antigens, CD19; D014408:Biomarkers, Tumor; D018956:CD5 Antigens; D016827:CD8 Antigens