title: An audit of nephroureterectomy for upper tract urothelial carcinoma.
abstract: BACKGROUND
  The boundary of nephroureterctomy has been revisited and lymph node dissection has been recommended recently. We investigated the role of synchronous ipsilateral adrenalectomy in treating patients with upper tract urothelial carcinoma.
  
  
  METHODS
  110 patients with clinically localized upper tract urothelial carcinoma treated by nephroureterectomy and bladder cuff resection were retrospectively evaluated. 70 patients underwent nephroureterectomy without concomitant ipsilateral adrenalectomy, whereas nephroureterectomy and ipsilateral adrenalectomy was performed in other 40 patients. Cancer specific, metastasis and local recurrence free survival during a follow-up of median 46 months were analyzed.
  
  
  RESULTS
  No patient had adrenal metastasis among the 40 adrenalectomized patients. A total of 4 patients developed local recurrences; including 1 of the 70 adrenalectomy-sparing and 3 of the 40 adrenalectomized patients (p = 0.102, chi-square test). Five patients with adrenalectomy and four without adrenalectomy had distant metastases (p = 0.212, chi-square test). The five-year local recurrence free survival (p = 0.09, log-rank test), metastasis-free survival (p = 0.292, log-rank test), and cancer-specific survival (p = 0.117, log-rank test) did not have significant difference between both groups.
  
  
  CONCLUSIONS
  This is the only study in recent 2 decades to evaluate the necessity of synchronous adrenalectomy in treating localized upper tract urothelial carcinoma. Adrenal-sparing nephroureterectomy seems justified for clinically localized upper tract urothelial carcinoma.
authors: Department of Urology, National Taiwan University Hospital and College of Medicine, National Taiwan University, #7 Chung-Shan South Road, Taipei, Taiwan.
authors: C-Y
authors: CY
authors: Huang
authors: S-D
authors: SD
authors: Chung
authors: S-M
authors: SM
authors: Wang
authors: C-H
authors: CH
authors: Liao
authors: M-K
authors: MK
authors: Lai
authors: K-H
authors: KH
authors: Huang
authors: Y-S
authors: YS
authors: Pu
authors: S-C
authors: SC
authors: Chueh
authors: H-J
authors: HJ
authors: Yu
mesh_terms: D000315:Adrenalectomy / Q000379:methods*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009392:Nephrectomy / Q000379:methods*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D014513:Ureter / Q000601:surgery*; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*