Delayed improvement of insulin secretion after autologous islet transplantation in partially pancreatectomized patients.
The purpose of this study was to evaluate the effects of autologous islet transplantation (ITx) on glucose homeostasis and insulin secretory function after partial pancreatectomy (Px). Fourteen nondiabetic patients who underwent distal Px and autologous ITx for benign pancreatic tumors were enrolled in the study (Px + ITx group). Fourteen normal glucose-tolerant controls and 6 Px without ITx controls were recruited, and all groups were followed over a 24-month period. They performed the 75-g oral glucose tolerance test and the 1-mg glucagon stimulation test. Hemoglobin A(1c) was measured, and indices of insulin secretion were calculated. In the Px + ITx group, insulin secretion increased after a nadir at 6 months. Glucose tolerance, which had been abruptly impaired immediately after Px, recovered until 6 months and stabilized thereafter. As a result, differences in glucose intolerance emerged between the subjects in the Px group and those in the Px + ITx group at 24 months after Px. Characteristic variables in the better insulin secretory subjects in the Px + ITx group included younger age, less extensive pancreas resection, and a greater number of total islets. In summary, delayed amelioration of glucose intolerance was induced by autologous ITx after partial Px, even with a small number of islets.
Jung
Hye Seung
HS
Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Choi
Seong-Ho
SH
Kim
Sung-Joo
SJ
Choi
Dong-Wook
DW
Heo
Jin-Seok
JS
Lee
Kyu Taek
KT
Lee
Jong Kyun
JK
Jang
Kee-Taek
KT
Lee
Byung-Wan
BW
Jee
Jae-Hwan
JH
Noh
Jung-Hyun
JH
Jeong
In Kyung
IK
Yang
Tae-Young
TY
Oh
Seung-Hoon
SH
Ahn
You-Ran
YR
Kim
Young-Seok
YS
No
Heesung
H
Lee
Moon-Kyu
MK
Kim
Kwang-Won
KW
D000328:Adult; D000375:Aging / Q000502:physiology; D005260:Female; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance / Q000517:prevention & control; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood*; D016381:Islets of Langerhans Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000601:surgery
D005947:Glucose; D006442:Glycated Hemoglobin; D007328:Insulin