Elongation of 1,3-polyols via iterative catalyst-directed carbonyl allylation from the alcohol oxidation level.
Iterative enantioselective carbonyl allylation from the alcohol oxidation level under the conditions of iridium catalyzed transfer hydrogenation enables chain elongation of 1,3-polyols. High levels of catalyst-directed enantioselectivity and diastereoselectivity are observed.
Hassan
Abbas
A
University of Texas at Austin, Department of Chemistry and Biochemistry, Austin, Texas 78712, USA.
Lu
Yu
Y
Krische
Michael J
MJ
D000438:Alcohols / Q000737:chemistry; D000498:Allyl Compounds / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D000498:Allyl Compounds; D011108:Polymers; C024617:polyol; D007495:Iridium