[Influence of antioxidants under polytrauma during traumatic sickness].
To study protective effect of Plapheron LB during grave traumatic sickness. Studied 94 patients with grave polytrauma, who were divided in to two groups of 47 patients. To I-st group was prescribed ordinary program of intensive therapy and to the II-nd group of patients additionally to the ordinary program of intensive therapy was made Plapheron LB in dose of 0.028 mg/kg two times a day sublingually during ten days. Grave condition of the patient was fixed by RTS scale and grave of shock by Skinner scale. Stated that each group was different in grave traumatic and shock conditions. Separately was studied group of health patients. The study was held by the method of electro-paramagnetic resonance of venous blood to admitted to hospital patients and on fifth day of intensive therapy. Noted: NO, FeS-NO, Fe(3+)-transpherin, Fe(2+) and Met-Hb. From immunology cytokin TNF-alpha was studied by the method of immunopherment. Results of study and discussion: Plapheron LB promotes decrease of the process of peroxide oxidation of lipids, increases activation of antioxidant ferments, stimulates production of nitric oxide and decreases the quantity of pyoinflammatory complication from those organs and systems which has no frequent effect of medical manipulation.
Nakashidze
I M
IM
Chikovani
T I
TI
Tsitsadze
N G
NG
Datunashvili
I V
IV
Sanikidze
T V
TV
D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D009104:Multiple Trauma / Q000188:drug therapy*; D009479:Neuropeptides / Q000627:therapeutic use*; D012774:Shock, Traumatic / Q000188:drug therapy*
D000975:Antioxidants; D009479:Neuropeptides; C091912:plaferon