Discovery of swine as a host for the Reston ebolavirus.
Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.
Barrette
Roger W
RW
Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, Animal and Plant Health Inspection Services, United States Department of Agriculture, Plum Island Animal Disease Center, New York, NY 11944, USA.
Metwally
Samia A
SA
Rowland
Jessica M
JM
Xu
Lizhe
L
Zaki
Sherif R
SR
Nichol
Stuart T
ST
Rollin
Pierre E
PE
Towner
Jonathan S
JS
Shieh
Wun-Ju
WJ
Batten
Brigid
B
Sealy
Tara K
TK
Carrillo
Consuelo
C
Moran
Karen E
KE
Bracht
Alexa J
AJ
Mayr
Gregory A
GA
Sirios-Cruz
Magdalena
M
Catbagan
Davinio P
DP
Lautner
Elizabeth A
EA
Ksiazek
Thomas G
TG
White
William R
WR
McIntosh
Michael T
MT
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004196:Disease Outbreaks / Q000662:veterinary; D004197:Disease Reservoirs; D029043:Ebolavirus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D018702:Filoviridae Infections / Q000150:complications / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D010679:Philippines / Q000453:epidemiology; D010802:Phylogeny; D019318:Porcine Reproductive and Respiratory Syndrome / Q000453:epidemiology / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D034421:Sus scrofa; D013553:Swine Diseases / Q000453:epidemiology / Q000821:virology*
D000914:Antibodies, Viral