Elevated erythropoietin in vitreous of patients with rhegmatogenous retinal detachment and proliferative vitreoretinopathy.
OBJECTIVE
Our purpose was to determine the vitreous erythropoietin (EPO) level in patients with rhegmatogenous retinal detachment (RRD) and proliferative vitreoretinopathy (PVR).


METHODS
The levels of EPO in vitreous were measured using a sandwich enzyme-linked immunosorbent assay kit from 64 patients, of whom 40 had RRD, 13 had PVR and 11 had idiopathic macular hole as control.


RESULTS
The mean levels of EPO in the RRD group (54.6 +/- 7.3 mU/ml) and PVR group (104.1 +/- 20.8 mU/ml) were significantly higher than that in the idiopathic macular hole control group (14.4 +/- 3.6 mU/ml; p < 0.001, p = 0.003, respectively). The mean EPO level in PVR was higher than that in RRD, but the difference was not significant (p = 0.112).


CONCLUSIONS
The vitreous EPO level was upregulated in eyes with RRD and PVR.
Wang
Zhao-Yang
ZY
Department of Ophthalmology, Zhejiang University School of Medicine, Hangzhou, China.
Shen
Li-Jun
LJ
Zhao
Ke-Ke
KK
Song
Zong-Ming
ZM
Qu
Jia
J
D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D004921:Erythropoietin / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D008875:Middle Aged; D012163:Retinal Detachment / Q000378:metabolism*; D012167:Retinal Perforations / Q000378:metabolism; D018630:Vitreoretinopathy, Proliferative / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism*
D004921:Erythropoietin