What is the true nature of the osteoblastic hematopoietic stem cell niche?
The recently revitalized interest in the regulation of hematopoietic stem cells (HSCs) by the bone marrow microenvironment has resulted in the identification of some important cell types that potentially form the HSC niche. The term 'osteoblast' has commonly been used to describe the endosteal elements of the HSC niche, but these cells are part of a larger family that functions in bone at different stages of differentiation. Given that there is much controversy as to what cell types have important roles in the HSC niche, this review offers an overview of the diverse osteoblastic cell types and discusses the current evidence regarding what roles they have in the HSC niche.
Askmyr
Maria
M
St Vincent's Institute, Fitzroy, Victoria, 3065, Australia.
Sims
Natalie A
NA
Martin
T John
TJ
Purton
Louise E
LE
D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D001854:Bone Marrow Cells / Q000502:physiology; D052005:Bone Morphogenetic Protein Receptors, Type I / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000166:cytology; D019070:Cell Lineage; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000502:physiology; D010006:Osteoblasts / Q000502:physiology*; D044168:Receptor, Parathyroid Hormone, Type 1 / Q000502:physiology; D055153:Stem Cell Niche / Q000502:physiology*; D009626:Terminology as Topic
D044168:Receptor, Parathyroid Hormone, Type 1; D052005:Bone Morphogenetic Protein Receptors, Type I