Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation.
Solid-phase oligonucleotide conjugation by nitrile oxide-alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.
Singh
Ishwar
I
Department of Chemistry, National University of Ireland, Maynooth, Co. Kildare, Republic of Ireland.
Vyle
Joseph S
JS
Heaney
Frances
F
D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000737:chemistry / Q000235:genetics; D007700:Kinetics; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000235:genetics
D009838:Oligodeoxyribonucleotides; D003300:Copper; D004247:DNA