Association of the alpha 2A adrenergic receptor -1291C/G polymorphism and antipsychotic-induced weight gain in European-Americans.
OBJECTIVE
To investigate the -1291 C/G promoter polymorphism (rs1800544) of the adrenergic alpha-2A receptor (ADRA2A) with clozapine-/olanzapine-induced weight gain in European-Americans and African-Americans. The alpha-adrenergic receptors inhibit lipolysis in the adipose tissue and are involved in weight gain regulation. Moreover, two previous studies indicated an association with antipsychotic-induced weight gain with the same polymorphism in Asian populations.


METHODS
We analyzed a relatively large (n=129) and well-characterized group of patients and monitored them for a period of 6-14 weeks. Our refined sample consisted of 60 European-Americans and 39 African-Americans on clozapine or olanzapine, prospectively.


RESULTS
In European-Americans, we observed a significant difference in weight gain across the genotypic categories (p=0.046). The carriers of the C allele gained more weight compared with the subjects homozygous for the GG allele (CC + CG vs GG; 3.73 +/- 4.13 kg vs 0.23 +/- 2.92 kg; p=0.013). We did not find a significant association in African-Americans, although the sample size was probably too small.


CONCLUSIONS
Our observations suggest a possible role of ADRA2A polymorphisms in clozapine-/olanzpaine-induced weight gain in subjects of European descent.
Sickert
Laertes
L
Charité University Medicine Berlin, Berlin, Germany.
Müller
Daniel J
DJ
Tiwari
Arun K
AK
Shaikh
Sajid
S
Zai
Clement
C
De Souza
Renan
R
De Luca
Vincenzo
V
Meltzer
Herbert Y
HY
Lieberman
Jeffrey A
JA
Kennedy
James L
JL
D000328:Adult; D001741:Black or African American / Q000235:genetics; D014150:Antipsychotic Agents / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics*; D044465:White People / Q000235:genetics*
C547768:ADRA2A protein, human; D014150:Antipsychotic Agents; D018341:Receptors, Adrenergic, alpha-2