title: [Effect of different duration of clopidogrel pretreatment on platelet activation in patients undergoing stenting].
abstract: OBJECTIVE
  To investigate the effect of two clopidogrel pretreatment duration on platelet activation in patients undergoing stenting.
  
  
  METHODS
  From July 2006 to December 2007 40 elective carotid or vertebral artery stenting patients were assigned into two groups: Group A (n = 24) initiated clopidogrel (75 mg/d) > or = 5 d before stenting; group B (n = 16) initiated 3 - 4 days. Platelet-monocyte aggregates and fibrinogen receptors analyzed by flow cytometric, and platelet aggregation tests using optical aggregometry, as well as serum soluble CD40 ligand quantified by enzyme-linked immunosorbent assay were assessed in peripheral blood samples obtained immediately before and at 0.5, 18 h and 6 d after stenting.
  
  
  RESULTS
  Platelet-monocyte aggregates, fibrinogen receptors and serum soluble CD40 ligand were higher in group B than in group A (14.59% vs 8.70%, P = 0.012; 4.87% vs 2.42%, P = 0.024; 5.79 microg/L vs 2.64 microg/L, P = 0.020) at 18 h after stenting. Serum soluble CD40 ligand was higher in group B than in group A (0.49 microg/L vs 0.31 microg/L, P = 0.033) at 0.5 h after stenting.
  
  
  CONCLUSIONS
  Premedication before stenting with clopidogrel 75 mg/d merely 3 - 4 d may be insufficient to achieve adequate platelet inhibition, whereas clopidogrel initiated at least 5 d could obtain preferable clinical antiplatelet efficacy.
authors: Department of Neurology, Beijing Hospital Ministry of Health, Beijing 100730, China.
authors: Fang
authors: F
authors: Liu
authors: Jia-Chun
authors: JC
authors: Liu
authors: Li-Jun
authors: LJ
authors: Wang
authors: Jin
authors: J
authors: Li
authors: Xiao-Dong
authors: XD
authors: Xu
authors: Yan
authors: Y
authors: Liu
authors: Yi-Ning
authors: YN
authors: Huang
authors: Da-Ming
authors: DM
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016893:Carotid Stenosis / Q000097:blood / Q000628:therapy; D000077144:Clopidogrel; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D015607:Stents; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013997:Time Factors
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine