[Correlation between single nucleotide polymorphism of prothrombin gene G20210 and deep vein thrombosis after total joint replacement].
OBJECTIVE
To evaluate the correlation between prothrombin gene G20210A mutation and deep vein thrombosis after total joint replacement through detecting distribution frequency of single nucleotide polymorphism of the gene in patients undergoing total joint replacement.


METHODS
PCR and direct sequencing of DNA are used to analyze the frequency of prothrombin gene G20210A mutation in 55 patients undergoing total joint replacement, and the relationship between the mutation and deep vein thrombosis after total joint replacement is evaluated.


RESULTS
Morbidity of prothrombin gene G20210A mutation in 55 patients is 0, both in either DVT group (27 patients) or non-DVT group (28 patients). There is no significant difference between the two groups (P>0.05).


CONCLUSIONS
Mutation of prothrombin gene G20210A in Chinese patients is rare, and there is no correlation between the genetic mutation and deep vein thrombosis after total joint replacement.
Jiang
Jun
J
Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing 100044, China.
Guan
Zhen-peng
ZP
Lü
Hou-shan
HS
D000328:Adult; D000368:Aged; D019643:Arthroplasty, Replacement / Q000009:adverse effects*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000209:etiology*; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors; D020246:Venous Thrombosis / Q000209:etiology*
D011516:Prothrombin