title: Non-contrast-enhanced perfusion and ventilation assessment of the human lung by means of fourier decomposition in proton MRI.
abstract: Assessment of regional lung perfusion and ventilation has significant clinical value for the diagnosis and follow-up of pulmonary diseases. In this work a new method of non-contrast-enhanced functional lung MRI (not dependent on intravenous or inhalative contrast agents) is proposed. A two-dimensional (2D) true fast imaging with steady precession (TrueFISP) pulse sequence (TR/TE = 1.9 ms/0.8 ms, acquisition time [TA] = 112 ms/image) was implemented on a 1.5T whole-body MR scanner. The imaging protocol comprised sets of 198 lung images acquired with an imaging rate of 3.33 images/s in coronal and sagittal view. No electrocardiogram (ECG) or respiratory triggering was used. A nonrigid image registration algorithm was applied to compensate for respiratory motion. Rapid data acquisition allowed observing intensity changes in corresponding lung areas with respect to the cardiac and respiratory frequencies. After a Fourier analysis along the time domain, two spectral lines corresponding to both frequencies were used to calculate the perfusion- and ventilation-weighted images. The described method was applied in preliminary studies on volunteers and patients showing clinical relevance to obtain non-contrast-enhanced perfusion and ventilation data.
authors: Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany. g.bauman@dkfz.de
authors: Grzegorz
authors: G
authors: Bauman
authors: Michael
authors: M
authors: Puderbach
authors: Michael
authors: M
authors: Deimling
authors: Vladimir
authors: V
authors: Jellus
authors: Christophe
authors: C
authors: Chefd'hotel
authors: Julien
authors: J
authors: Dinkel
authors: Christian
authors: C
authors: Hintze
authors: Hans-Ulrich
authors: HU
authors: Kauczor
authors: Lothar R
authors: LR
authors: Schad
mesh_terms: D000465:Algorithms; D003287:Contrast Media; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D009068:Movement; D011522:Protons; D011652:Pulmonary Circulation / Q000502:physiology*; D015203:Reproducibility of Results; D015656:Respiratory Mechanics / Q000502:physiology*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D011522:Protons