[Effect of laparoscopic-assisted resection of rectal carcinoma on C-reactive protein and humoral immunity].
OBJECTIVE
To investigate the effect of laparoscopic-assisted resection of rectal carcinoma on perioperative levels of C-reactive protein (CRP), immunoglobulins(Ig) and complements.


METHODS
Fifty-four patients with rectal carcinoma were divided into laparoscopic group (n=26) and open operation group(n=28) according to the patients' will. C-reactive protein (CRP), IgG, IgA, IgM, C(3), C(4) and CH(50) of peripheral blood were assayed preoperatively and on the 1st, 2nd, 3rd and 7th day postoperatively.


RESULTS
Compared with the preoperative period, the CRP levels in both groups were significantly increased on the 1st, 2nd, and 3rd day(P<0.01) and peaked on the 2nd day postoperatively. The postoperative CRP levels were significantly lower in the laparoscopic group than those in the open operation group(P<0.01). After operation, the immunoglobulin levels were significantly decreased in both groups(P<0.01), and there were no significant differences in IgG and IgM. The levels of C(3), C(4) and CH(50) were significantly decreased after operation in both groups(P<0.05) and returned to the preoperative levels during postoperative 48-72 hours in laparoscopic group.


CONCLUSIONS
Laparoscopic-assisted resection of rectal carcinoma results in less wound, lower levels of stress response, and less effect on immune function compared to open surgery, which recovers the immune function of patients more rapidly after operation.
He
Wei
W
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Deng
Hai-jun
HJ
Yu
Jiang
J
Zhang
Ce
C
Wang
Ya-nan
YN
Cheng
Xia
X
Li
Guo-xin
GX
D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D056724:Immunity, Humoral; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000097:blood* / Q000276:immunology* / Q000601:surgery
D002097:C-Reactive Protein