title: Infectious pericarditis: an experience spanning a decade.
abstract: BACKGROUND
  Although recent literature suggests a changing spectrum for infectious pericarditis (IP), this view has not been proven. In this report, we aim to review the features of IP in cases from a large tertiary centre.
  
  
  METHODS
  A retrospective review of our institution's database was conducted to identify cases with IP between January 1994 and December 2004. All pericardial biopsy tissue results from the same period were also reviewed.
  
  
  RESULTS
  One hundred and thirty-eight cases were identified, of which 14 cases were identified by pathology. The mean age was 53 +/- 18 years, and 74% were men. The most frequently identified causative organisms were Propionibacterium acnes (P. acnes), staphylococci and streptococci. A common predisposing factor was an immune-compromised state, followed by cardiac surgery. Fifty-five patients were treated with antibiotics (medical group) while 63 cases (surgical group) underwent surgical drainage (pericardial window) and/or pericardiectomy. In comparison to the medical group, the surgical group was more critically ill and immunocompromised (40% versus 24%, respectively). There were 52 late deaths during follow-up. Mortality in the medical group was 67% while in the surgical group it was 24% (P < 0.0001).
  
  
  CONCLUSIONS
  In contradistinction to the literature reports, the most prevalent organism for IP was P. acnes. Patients managed aggressively with both antibiotics and surgery, demonstrated lower mortality rates. Therefore, clinicians should maintain a high index of suspicion for IP so that timely and appropriate mortality-reducing strategies can be offered.
authors: Mayo Clinic, Department of Cardiovascular Diseases, Scottsdale, AZ 85255, USA. mookadam.farouk@mayo.edu
authors: Farouk
authors: F
authors: Mookadam
authors: Sherif E
authors: SE
authors: Moustafa
authors: Yinguang
authors: Y
authors: Sun
authors: Floranne C
authors: FC
authors: Wilson
authors: Shazli S
authors: SS
authors: Mohammed
authors: Soon
authors: S
authors: Park
authors: Imad M
authors: IM
authors: Tleyjeh
authors: Jae K
authors: JK
authors: Oh
authors: Jamil
authors: J
authors: Tajik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010492:Pericardiectomy; D020519:Pericardiocentesis; D010493:Pericarditis / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality* / Q000601:surgery; D011425:Propionibacterium acnes / Q000302:isolation & purification*; D012189:Retrospective Studies; D012307:Risk Factors; D013210:Staphylococcus / Q000302:isolation & purification; D013291:Streptococcus / Q000302:isolation & purification; D013396:Suction; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents