Direct N-carbamoylation of 3-monosubstituted oxindoles with alkyl imidazole carboxylates.
Regioselective N-carbamoylation of oxindoles was achieved through the use of imidazole carboxylate reagents. This reaction provides ready access to N-carbamoyl-3-monosubstituted oxindoles.
Trost
Barry M
BM
Department of Chemistry, Stanford University, 337 Campus Drive, Stanford, California 94305-5080, USA. bmtrost@stanford.edu
Zhang
Yong
Y
Zhang
Ting
T
D002264:Carboxylic Acids / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction; D000078183:Oxindoles; D013237:Stereoisomerism
D002264:Carboxylic Acids; D007093:Imidazoles; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D009584:Nitrogen