title: Cognitive inhibition of number/length interference in a Piaget-like task: evidence by combining ERP and MEG.
abstract: OBJECTIVE
  We combined event-related potential (ERP) and magnetoencephalography (MEG) acquisition and analysis to investigate the electrophysiological markers of the inhibitory processes involved in the number/length interference in a Piaget-like numerical task.
  
  
  METHODS
  Eleven healthy subjects performed four gradually interfering conditions with the heuristic "length equals number" to be inhibited. Low resolution tomography reconstruction was performed on the combined grand averaged electromagnetic data at the early (N1, P1) and late (P2, N2, P3(early) and P3(late)) latencies. Every condition was analyzed at both scalp and regional brain levels.
  
  
  RESULTS
  The inhibitory processes were visible on the late components of the electromagnetic brain activity. A right P2-related frontal orbital activation reflected the change of strategy in the inhibitory processes. N2-related SMA/cingulate activation revealed the first occurrence of the stimuli processing to be inhibited. Both P3 components revealed the working memory processes operating in a medial temporal complex and the mental imagery processes subtended by the precuneus.
  
  
  CONCLUSIONS
  Simultaneous ERP and MEG signal acquisition and analysis allowed to describe the spatiotemporal patterns of neural networks involved in the inhibition of the "length equals number" interference.
  
  
  CONCLUSIONS
  Combining ERP and MEG ensured a sensitivity which could be reached previously only through invasive intracortical recordings.
authors: CI-NAPS, Centre d'Imagerie Neurosciences et Applications aux Pathologies, UMR6232, CNRS, CEA, Université de Caen Basse Normandie et Université Paris Descartes, GIP Cyceron, BP 5229, Caen, France. joliot@cyceron.fr
authors: Marc
authors: M
authors: Joliot
authors: Gaëlle
authors: G
authors: Leroux
authors: Stéphanie
authors: S
authors: Dubal
authors: Nathalie
authors: N
authors: Tzourio-Mazoyer
authors: Olivier
authors: O
authors: Houdé
authors: Bernard
authors: B
authors: Mazoyer
authors: Laurent
authors: L
authors: Petit
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007600:Judgment; D015225:Magnetoencephalography; D008297:Male; D008433:Mathematics; D009434:Neural Pathways / Q000502:physiology; D025341:Principal Component Analysis; D011930:Reaction Time / Q000502:physiology; D013647:Task Performance and Analysis; D055815:Young Adult