Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways.
A neuropathological characteristic of Alzheimer's disease is the extracellular accumulation of amyloid beta peptide (Abeta) in neuritic plaques. Recent evidences suggested that soluble Abeta oligomers are the predominant neurotoxic species for neurons. Thus, considerable attention has been paid to discriminate the cytotoxic pathways of Abeta pre-fibrillar aggregates and mature fibrils. We showed that the mechanisms by which Abeta oligomers and fibrils generated reactive oxygen species differ in terms of site of production and kinetics, suggesting the involvement of different intra/extracellular pathways.
Cenini
Giovanna
G
Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25124, Brescia, Italy.
Giovanna
Cenini
C
Cecchi
Cristina
C
Pensalfini
Anna
A
Bonini
Sara Anna
SA
Ferrari-Toninelli
Giulia
G
Liguri
Gianfranco
G
Memo
Maurizio
M
Uberti
Daniela
D
D000327:Adsorption / Q000187:drug effects; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D000682:Amyloid / Q000737:chemistry / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects; D003600:Cytosol / Q000378:metabolism; D004705:Endocytosis / Q000187:drug effects; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D018613:Microscopy, Confocal; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000682:Amyloid; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D017382:Reactive Oxygen Species; C075222:amyloid beta-protein (1-42); D003078:Colchicine