[PANDAS with a chorea-like clinical presentation and associated autoimmune pathology: a case report].
BACKGROUND
The disorder known as 'PANDAS syndrome' (paediatric autoimmune neuro-psychiatric disorders associated with Streptococci) consists in an abrupt onset of obsessive-compulsive symptoms and/or movement disorders, a pre-puberal onset, and an episodic course. Antibiotic therapy has been postulated as a first choice therapeutic option. A summarised review of main literature on this topic is presented.


METHODS
A girl, 10 years and 6 months old, with a dramatic clinical onset of a chorea-like and obsessive-compulsive symptomathology with a remarkable improvement after 10 days penicillin p.o. intake. She has a positive family history of autoimmune disorders, with elevated anti-phospholipidic antibodies.


CONCLUSIONS
The implications of the case follow-up with many relapses, the development of a diabetes after corticoid therapy and the elevated anti glutamic dexcarboxilasa (anti-GAD) are discussed regarding a common underlying autoimmune mechanism.
Otero-Cuesta
S
S
Unidad de Psiquiatría y Psicología Infanto-Juvenil (UPPIJ), Servicio de Psiquiatría, Servicio de Pediatría, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain. sotero@humv.es
Fernández-Torre
O
O
González-Lamuño
D
D
D001327:Autoimmune Diseases / Q000175:diagnosis*; D002648:Child; D002819:Chorea / Q000175:diagnosis; D005260:Female; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis*; D009422:Nervous System Diseases / Q000175:diagnosis*; D013290:Streptococcal Infections / Q000175:diagnosis*; D013577:Syndrome