The immune boundaries for stem cell based therapies: problems and prospective solutions.
Stem cells have fascinated the scientific and clinical communities for over a century. Despite the controversy that surrounds this field, it is clear that stem cells have the potential to revolutionize medicine. However, a number of significant hurdles still stand in the way of the realization of this potential. Chiefly among these are safety concerns, differentiation efficiency and overcoming immune rejection. Here we review current progress made in this field to optimize the safe use of stem cells with particular emphasis on prospective interventions to deal with challenges generated by immune rejection.
Hmadcha
Abdelkrim
A
Department of Cell Therapy and Regenerative Medicine, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Sevilla, Spain. karim.hmadcha@cabimer.es
Abdelkrim
Hmadcha
H
Domínguez-Bendala
Juan
J
Juan
Domínguez-Bendala
DB
Wakeman
Jane
J
Jane
Wakeman
W
Arredouani
Mohamed
M
Mohamed
Arredouani
A
Soria
Bernat
B
Bernat
Soria
S
D000818:Animals; D006084:Graft Rejection / Q000276:immunology; D006648:Histocompatibility / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000145:classification / Q000166:cytology