Immunoregulatory effects of HO-1: how does it work?
The heme-catabolizing enzyme heme oxygenase-1 (HO-1; encoded by the Hmox1 gene) inhibits the pathogenesis of several immune-mediated inflammatory diseases. This unusually broad salutary effect is thought to rely on the immunoregulatory actions of HO-1, exerted on innate and adaptive immune cells. According to this notion, HO-1 'dampens' innate and adaptive immune responses, limiting immune-mediated tissue injury and thus suppressing the pathogenesis of immune-mediated inflammatory diseases. We will argue that the salutary effects of HO-1 are also exerted via its cytoprotective action, which sustains tissue function and prevents unfettered immune activation by endogenous proinflammatory ligands released from injured cells.
Soares
Miguel P
MP
Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal. mpsoares@igc.gulbenkian.pt
Marguti
Ivo
I
Cunha
Andreia
A
Larsen
Rasmus
R
D000818:Animals; D051547:Heme Oxygenase-1 / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D018836:Inflammation Mediators / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology
D018836:Inflammation Mediators; D051547:Heme Oxygenase-1