[Serum adiponectin and resistin level in children with idiopathic nephrotic syndrome].
The adipose tissue was recognized as an active endocrine organ. The adipopkines seem to play an important role in the modulation of inflammatory response and have a pleiotropic function. The aim of this study was to evaluate serum resistin and adiponectin level in children with idiopathic nephrotic syndrome (INS).


METHODS
39 children with INS aged 2.5-17 year (mean 9.35 +/- 5.6), 15 children in relapse, 24 in remission and 8 healthy were included into the study. Serum total protein, albumin, cholesterol, daily proteinuria and BMI were measured in children with INS. Serum resistin and adiponectin levels were determined by ELISA.


RESULTS
Increased resistin and adiponectin levels were observed during relapse and remission of INS, compared to controls. No significant difference between adipocytokines in relapse and remission INS was found. Serum resistin level decreased in remission of INS, compared to relapse, but the value did not reach statistical significance. Between resistin and cholesterol, resistin and proteinuria positive correlation was found. Negative correlation between resistin and serum albumin was observed.


CONCLUSIONS
Increased serum level of resistin and adiponectin was observed in children with relapse of INS or in early phase of remission. These finding suggests that they may play a role in the pathogenesis of INS in children. It requires further investigation based on a broad study.
Medyńska
Anna
A
Department of Pediatric Nephrology of Medical University of Wroclaw.
Kiliś-Pstrusińska
Katarzyna
K
Galar
Anna
A
Zwolińska
Danuta
D
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood*; D052243:Resistin / Q000097:blood*
D052242:Adiponectin; D052243:Resistin