Radiographic evidence of mandibular osteoporosis improvement in Wistar rats treated with Ginkgo biloba.
OBJECTIVE
Evaluate the effects of the extract of Ginkgo biloba (EGb) on the rat mandibular glucocorticoid-induced-osteoporosis.


METHODS
36 female rats were divided into six groups (n=6): control, osteoporosis, positive control and EGb1 (14 mg/kg/day), EGb2 (28 mg/kg/day), and EGb3 (56 mg/kg/day) treatment. Treatments were conducted for 30 days after osteoporosis induction. The animals were euthanized and their left mandibles were removed and radiographed to evaluate the cortical and the periodontal bone support. The control group was compared with the osteoporosis group (Student's t-test). The other groups were analyzed by ANOVA test followed by Tukey post-hoc test (p < 0.05).


RESULTS
There was a significant reduction in periodontal bone support in the osteoporosis group. The positive control group showed a significant increase in the mesial periodontal bone support, as well as the EGb group treated with 28 and 56 mg/Kg, which showed a significant increase in the mesial and distal periodontal bone support. The mandibular cortical was not affected by osteoporosis; however, the group treated with EGb using 56 mg/Kg showed a significant increase in the thickness of the mandibular cortical.


CONCLUSIONS
The EGb recovered the periodontal bone support and increased the mandibular cortical thickness. The EGb may be effective in the treatment of osteoporosis.
Lucinda
Leda Marília Fonseca
LM
Centro de Biologia da Reprodução, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil. ledamarilia@yahoo.com.br
de Oliveira
Tânia Toledo
TT
Salvador
Pollyanna Amaral
PA
Peters
Vera Maria
VM
Reis
João Evangelista de Paula
JE
Guerra
Martha de Oliveira
Mde O
D000818:Animals; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D008334:Mandible / Q000187:drug effects / Q000473:pathology*; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts