[ZnPP IX and L-NAME reduce the cGMP content in the penile tissue of rats].
OBJECTIVE
To investigate the effects of CO release inhibitor zinc protoporphyria IX (ZnPP IX) and NO release inhibitor L-NAME on the content of cGMP in the penile tissue of rats.


METHODS
Thirty Wistar rats were randomly divided into a normal control, a ZnPP IX, and an L-NAME group, given saline (1 ml/kg/d), ZnPP IX (45 micromol/kg/d) and L-NAME (50 mg/kg/d), respectively, for 7 days. Then all the rats were killed, homogenate made from their penile tissues and detected for the contents of NOS, NO, CO and cGMP.


RESULTS
The contents of CO, NOS, NO and cGMP were all reduced in both the ZnPP IX and L-NAME groups as compared with the control group (P < 0.05).


CONCLUSIONS
ZnPP IX and L-NAME can reduce the concentrations of CO and NO in the penile tissues of rats, and consequently the content of cGMP.
Ma
Hong-Bin
HB
Department of Urology, The First Hospital Affiliated to Jiamusi University, Jiamusi, Heilongjiang 154002, China.
Qin
Wen-bo
WB
Gui
Shi-liang
SL
D000818:Animals; D002248:Carbon Monoxide / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010413:Penis / Q000187:drug effects / Q000378:metabolism*; D011524:Protoporphyrins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D011524:Protoporphyrins; C017803:zinc protoporphyrin; D009569:Nitric Oxide; D002248:Carbon Monoxide; D006152:Cyclic GMP; D019331:NG-Nitroarginine Methyl Ester