Elastic liposomes for topical and transdermal drug delivery.
Elastic vesicles have been developed and evaluated as novel topical and transdermal delivery systems. They are similar to conventional liposomes but with the incorporation of an edge activator in the lipid bilayer structure to provide elasticity. Elastic vesicles are applied non-occluded to the skin and have been shown to permeate through the stratum corneum lipid lamellar regions as a result of the hydration or osmotic force in the skin. They have been investigated as drug carriers for a range of small molecules, peptides, proteins and vaccines, both in vitro and in vivo. Following topical application, structural changes in the stratum corneum have been identified and intact elastic vesicles visualised within the stratum corneum lipid lamellar regions, but no intact vesicles have been identified in the deeper viable tissues. Their method of transporting their drug payload into and through the skin has been investigated but remains an area of contention. This review provides an overview of the development of elastic vesicles for delivery into and via the skin.
Benson
Heather A E
HA
Curtin Health Innovation Research Institute, School of Pharmacy, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia. h.benson@curtin.edu.au
D000279:Administration, Cutaneous; D000818:Animals; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D004548:Elasticity; D006801:Humans; D008081:Liposomes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012869:Skin Absorption / Q000502:physiology
D004337:Drug Carriers; D008081:Liposomes; D004364:Pharmaceutical Preparations