title: Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population: case-parent design.
abstract: CTLA-4 plays a key role in T cells regulation. We analysed the CTLA-4 +49A/G and -318C/T polymorphisms in 178 cases of type 1 diabetes and their parents (534 individuals) from Santiago, Chile. A significant overall association with T1D (p=0.028) was observed, possibly due to an overtransmission of the G-T haplotype.
authors: Genetic Epidemiology Laboratory, Nutrition and Food Technology Institute (INTA), University of Chile, Santiago, Chile.
authors: Bárbara
authors: B
authors: Angel
authors: Iván
authors: I
authors: Balic
authors: José Luis
authors: JL
authors: Santos
authors: Ethel
authors: E
authors: Codner
authors: Elena
authors: E
authors: Carrasco
authors: Francisco
authors: F
authors: Pérez-Bravo
mesh_terms: D015703:Antigens, CD / Q000235:genetics* / Q000276:immunology; D060908:CTLA-4 Antigen; D002677:Chile; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005091:Exons / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009154:Mutation; D016017:Odds Ratio; D010290:Parents; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human