title: Higher incidence of relapse with peripheral blood rather than marrow as a source of stem cells in adults with acute myelocytic leukemia autografted during the first remission.
abstract: OBJECTIVE
  The cell source for autologous stem cell transplantation has shifted from bone marrow (BM) to peripheral blood (PB). In acute myelocytic leukemia (AML), for patients who receive transplants during first complete remission (CR1), no prospective randomized study has compared relapse incidence (RI) to cell source.
  
  
  METHODS
  We analyzed 2,165 patients who received autografts (1,607 PB and 558 BM) from 1994 to 2006 and were reported to the European Cooperative Group for Blood and Marrow Transplantation with complete research data. Relative to the time of CR1, PB transplants were performed earlier than BM transplants. Because a poorer outcome was associated with a shorter interval from CR1 to transplantation, patients were divided into three groups: BM, early PB (< or = 80 days after CR1), and late PB (> 80 days after CR1) transplantation.
  
  
  RESULTS
  In a multivariate analysis adjusted for differences between groups and center, RI was higher with both early PB (56% +/- 3%; hazard ratio [HR], 1.45; 95% CI, 1.11 to 1.9; P = .006) and late PB transplantation (46% +/- 2%; HR, 1.3; 95% CI, 1.06 to 1.59; P = .01) as compared with BM transplantation (39% +/- 2%). This translated into a significantly worse leukemia-free survival (LFS) for early PB transplantation (36% +/- 3%; HR, 0.75; 95% CI, 0.58 to 0.96; P = .02) and a trend for a poorer LFS for late PB (46% +/- 2%; HR, 0.84; 95% CI, 0.7 to 1.01; P = .06) as compared with BM (52% +/- 2%).
  
  
  CONCLUSIONS
  For patients with AML in CR1, risk of relapse is greater with PB transplantation rather than BM, independent of the interval from CR1 to transplantation.
authors: Hopital Saint-Antoine, Department of Hematology, Paris, France. norbert-claude.gorin@sat.aphp.fr
authors: Norbert-Claude
authors: NC
authors: Gorin
authors: Myriam
authors: M
authors: Labopin
authors: Didier
authors: D
authors: Blaise
authors: Josy
authors: J
authors: Reiffers
authors: Giovanna
authors: G
authors: Meloni
authors: Mauricette
authors: M
authors: Michallet
authors: Theo
authors: T
authors: de Witte
authors: Michel
authors: M
authors: Attal
authors: Bernard
authors: B
authors: Rio
authors: Francois
authors: F
authors: Witz
authors: Loic
authors: L
authors: Fouillard
authors: Roel
authors: R
authors: Willemze
authors: Vanderson
authors: V
authors: Rocha
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D036102:Peripheral Blood Stem Cell Transplantation; D011379:Prognosis; D012008:Recurrence; D014182:Transplantation, Autologous