Allele and genotype frequencies of cytochrome P450 2B6 gene in a Mongolian population.
CYP2B6 plays an important role in metabolizing various drugs in common clinical use. Increasing interest in CYP2B6 genetic polymorphism was stimulated by revelations of a specific CYP2B6 genotype significantly affecting the metabolism of efavirenz, an anti-HIV type-1 agent. The present study determined the CYP2B6 haplotype in 100 healthy unrelated Mongolian volunteers by analyzing the genotypes of nine single nucleotide polymorphism (SNP) positions (-82T>C, 64C>T, 499C>T, 516G>T, 777C>A, 785A>G, 983T>C, 1375A>G, and 1459C>T) in the CYP2B6 gene. The CYP2B6 *1 allele was the most frequent in the Mongolian population tested at 64.5%, higher than the equivalent frequency in African-Americans and Ghanaians. The second most frequent allele was CYP2B6 *6 (21.0%), although this allele was less frequent than that in Ghanaians. Only one CYP2B6 *5 allele was identified in our Mongolian subjects (0.5%), although it is the third most frequent allele in white and African-American populations. These CYP2B6 genotypes revealed seven slow efavirenz metabolizers in 100 Mongolians, which is significantly fewer than the same group among Ghanaians. Overall, the Mongolian CYP2B6 allele distribution was comparable with that in Japanese, Koreans, and Han Chinese. This is the first report of CYP2B6 genotype frequency in a Mongolian population, and it could provide clinically useful information on drug metabolism in this population group.
Davaalkham
Jagdagsuren
J
AIDS Clinical Center, International Medical Center of Japan, Tokyo 162-8655, Japan.
Hayashida
Tsunefusa
T
Tsuchiya
Kiyoto
K
Gatanaga
Hiroyuki
H
Nyamkhuu
Dulmaa
D
Oka
Shinichi
S
D000480:Alkynes; D000483:Alleles; D019380:Anti-HIV Agents / Q000494:pharmacology; D001189:Aryl Hydrocarbon Hydroxylases / Q000145:classification* / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D048588:Benzoxazines / Q000494:pharmacology; D044383:Black People; D003521:Cyclopropanes; D065702:Cytochrome P-450 CYP2B6; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D010089:Oxidoreductases, N-Demethylating / Q000145:classification* / Q000235:genetics; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups / Q000235:genetics*; D001741:Black or African American
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; C585599:CYP2B6 protein, human; D065702:Cytochrome P-450 CYP2B6; D010089:Oxidoreductases, N-Demethylating; C098320:efavirenz