title: Trisomy 8 in two newly diagnosed Chinese patients with chronic lymphocytic leukemia.
abstract: Chronic lymphocytic leukemia (CLL) is one of the most common lymphoid malignancies in Western countries, but is infrequent in Asian populations. To verify the incidence of trisomy 8 in Chinese patients with CLL, fluorescence in situ hybridization (FISH) was used in 140 CLL patients after routine chromosome analysis. Only two patients (1.4%) were found with trisomy 8, and the number of trisomy 8 cells was 8 and 10%, respectively. No other aberrations by "panel" probe FISH were found in these two patients. The chromosome karyotypes of two patients were 47,XY,+8[2]/49,XY,+14,+20,+21[2]/46,XY[16] and 47,XX,+8[2]/46,XX[18], respectively. Neither of the patients' present signs of myelodysplastic or myeloproliferative disorder appeared on the bone marrow aspirates and peripheral blood smear. Our study demonstrates that trisomy 8 is rare in CLL, and its role in prognosis of CLL remains unknown.
authors: Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing, China.
authors: Wei
authors: W
authors: Xu
authors: Xin
authors: X
authors: Cao
authors: Qiong
authors: Q
authors: Liu
authors: Lei
authors: L
authors: Fan
authors: Kou-Rong
authors: KR
authors: Miao
authors: Hai-Rong
authors: HR
authors: Qiu
authors: Dan-Xia
authors: DX
authors: Zhu
authors: Hong-Xia
authors: HX
authors: Qiu
authors: Jian-Yong
authors: JY
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002681:China; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy / Q000175:diagnosis* / Q000235:genetics*