[Sir2 gene].
In Japan, the ratio of people 65 years old and over against total population is about 22 % and we face a critical problem of aging population. Accumulating evidence in the world suggests that Sirt1, an NAD(+)-dependent protein deacetylase, plays an important role in modulation of aging. We discuss a potential therapeutic target, Sirt1 and challenge for prevention of age-related diseases (Alzheimer's dementia, osteoporosis, sarcopenia, arteriosclerosis and cancer).
Ota
Hidetaka
H
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo.
D000375:Aging / Q000235:genetics; D000818:Animals; D005853:Geriatrics; D006801:Humans; D037761:Sirtuins / Q000235:genetics*
D037761:Sirtuins