Skin decontamination with mineral cationic carrier against sarin determined in vivo.
Our Institute's nuclear, biological, and chemical defense research team continuously investigates and develops preparations for skin decontamination against nerve agents. In this in vivo study, we evaluated skin decontamination efficacy against sarin by a synthetic preparation called Mineral Cationic Carrier (MCC) with known ion exchange, absorption efficacy and bioactive potential. Mice were treated with increasing doses of sarin applied on their skin, and MCC was administered immediately after contamination. The results showed that decontamination with MCC could achieve therapeutic efficacy corresponding to 3 x LD(50) of percutaneous sarin and call for further research.
Vucemilović
Ante
A
Institute of Researches and Development of Defense Systems, Zagreb, Croatia. ante.vucemilovic@inet.hr
Hadzija
Mirko
M
Jukić
Ivan
I
D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D003666:Decontamination; D051379:Mice; D016688:Mice, Inbred NOD; D012524:Sarin / Q000633:toxicity*; D012867:Skin; D017641:Zeolites / Q000627:therapeutic use*
D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; C545217:Mineral Cationic Carrier; D017641:Zeolites; D012524:Sarin