Weight reduction can decrease circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in overweight middle-aged men.
Circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) has been reported to be associated with acute coronary syndrome, but its association with obesity has not been elucidated. In this study, we examined whether weight reduction would reduce the serum levels of sLOX-1 in a 12-week weight reduction intervention. Thirty-eight overweight middle-aged men were enrolled in the study, and 32 completed the intervention. The serum level of sLOX-1 was measured using a chemiluminescent enzyme-linked immunoassay. After the intervention program, body weight and the serum level of sLOX-1 decreased significantly (-7.5% +/- 4.8% and -72.1% +/- 35.9%, respectively). Changes in serum levels of sLOX-1 were positively correlated with changes in body weight (r = 0.54, P = .003), body mass index (r = 0.57, P = .001), body fat mass (r = 0.57, P = .002), total cholesterol (r = 0.41, P = .03), subcutaneous fat area (r = 0.50, P = .007), high-sensitivity C-reactive protein (r = 0.56, P = .002), leptin (r = 0.47, P = .01), and tumor necrosis factor-alpha (r = 0.32, P = .09); but no correlations were observed with fasting glycemic-related factors (blood glucose, hemoglobin A(1c), and insulin). Changes in body mass index and high-sensitivity C-reactive protein were selected as significant predictors of sLOX-1 changes by multiple regression analyses. These results suggest that LOX-1 induction may be related to adipocyte metabolism, inflammation, and immune response associated with obesity.
Nomata
Yasuhiro
Y
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan. y-nomata@stat.taiiku.tsukuba.ac.jp
Kume
Noriaki
N
Sasai
Hiroyuki
H
Katayama
Yasutomi
Y
Nakata
Yoshio
Y
Okura
Tomohiro
T
Tanaka
Kiyoji
K
D000328:Adult; D000368:Aged; D050218:Body Fat Distribution; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D004035:Diet Therapy; D005081:Exercise Therapy; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood / Q000628:therapy*; D051127:Scavenger Receptors, Class E / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha; D015431:Weight Loss / Q000502:physiology*
D007328:Insulin; D020738:Leptin; D051127:Scavenger Receptors, Class E; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein