title: Wound healing activity of flower extract of Calendula officinalis.
abstract: The effects of oral and topical application of Calendula officinalis flower extract on excision wounds made in rats were checked. The parameters assessed were the days needed for re-epithelization and percentage of wound closure. The hydroxy proline and hexosamine content in the granuloma tissue of the wound was also measured. The percentage of wound closure was 90.0% in the extract-treated group, whereas the control group showed only 51.1% on the eighth day of wounding (p < .01). The days needed for re-epithelization were 17.7 for the control animals; extract treatment at a dose of 20 or 100 mg/kg b.wt reduced the period to 14 and 13 days, respectively. A significant increase was observed in the hydroxy proline and hexosamine content in the extract-treated group compared with the untreated animals. The data indicate potent wound healing activity ofC. officinalis extract.
authors: Department of Biochemistry, Amala Cancer Research Centre Amala Nagar, Thrissur-680555, Kerala, India.
authors: Korengath C
authors: KC
authors: Preethi
authors: Ramadasan
authors: R
authors: Kuttan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D020838:Calendula / Q000737:chemistry; D002338:Carotenoids / Q000494:pharmacology; D005260:Female; D035264:Flowers; D006595:Hexosamines / Q000032:analysis; D006909:Hydroxyproline / Q000032:analysis; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D006595:Hexosamines; D010936:Plant Extracts; D002338:Carotenoids; D006909:Hydroxyproline