title: Langerhans cell migration: not necessarily always at the center of the skin sensitization universe.
abstract: Since their discovery in 1868, the role of Langerhans cells (LCs) in skin immunity has been researched extensively. Recent data deriving from transgenic animals that are deficient in LCs have begun to challenge the dogma that there is a universal requirement for these cells in the development of skin sensitization. This Commentary addresses relationships between LC mobilization, draining lymph node activation, and skin sensitization using immunomodulators agonistic for a family of sphingosine-1-phosphate (S1P) receptors.
authors: Faculty of Life Sciences, University of Manchester, Manchester, UK. ian.kimber@manchester.ac.uk
authors: Ian
authors: I
authors: Kimber
authors: Marie
authors: M
authors: Cumberbatch
authors: Rebecca J
authors: RJ
authors: Dearman
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D017449:Dermatitis, Allergic Contact / Q000517:prevention & control*; D000068876:Fingolimod Hydrochloride; D006801:Humans; D007801:Langerhans Cells / Q000187:drug effects / Q000502:physiology*; D008246:Lysophospholipids / Q000494:pharmacology*; D011409:Propylene Glycols / Q000494:pharmacology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D008246:Lysophospholipids; D011409:Propylene Glycols; C060506:sphingosine 1-phosphate; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine