Evaluating the potential public health impact of a Staphylococcus aureus vaccine through use of population-based surveillance for invasive methicillin-resistant S. aureus disease in the United States.
We evaluated the potential effects of a hypothetical vaccine in preventing invasive methicillin-resistant Staphylococcus aureus (MRSA) disease in the United States. Using an active, population-based surveillance program, we estimated baseline disease rates in the United States and compared three distinct vaccination strategies which targeted adults > or =65 years of age, persons at risk for recurrent invasive infection, and patients at hospital discharge. The strategies were projected to reduce the burden of invasive MRSA disease by 12.1%, 13.9% and 17.6%, respectively; with the strategy of vaccinating both adults > or =65 years of age and all adults at hospital discharge having the greatest impact per dose. Our data suggest that availability of an effective S. aureus vaccine could result in substantial reductions in invasive MRSA disease incidence. As candidate vaccines are evaluated, these data will be important in determining the optimal vaccination strategy.
Lucero
Cynthia A
CA
Centers for Disease Control and Prevention, NE, Atlanta, GA 30333, United States.
Hageman
Jeffrey
J
Zell
Elizabeth R
ER
Bulens
Sandra
S
Nadle
Joelle
J
Petit
Susan
S
Gershman
Ken
K
Ray
Susan
S
Harrison
Lee H
LH
Lynfield
Ruth
R
Dumyati
Ghinwa
G
Townes
John M
JM
Schaffner
William
W
Fridkin
Scott K
SK
D000293:Adolescent; D000328:Adult; D000368:Aged; D017281:Cost of Illness; D004196:Disease Outbreaks / Q000517:prevention & control; D006801:Humans; D017589:Immunization Programs; D017053:Infection Control; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D008875:Middle Aged; D011159:Population Surveillance; D012680:Sensitivity and Specificity; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000517:prevention & control*; D013209:Staphylococcal Vaccines / Q000276:immunology*; D014481:United States / Q000453:epidemiology; D055815:Young Adult
D013209:Staphylococcal Vaccines