Neurotrophic effects: Axoplasmic transport involvement in the regulation of skeletal muscle soluble proteins.
Skeletal muscle soluble proteins were assayed by polyacrylamide gel disc-electrophoresis at different times (4-36 days) after injection of 10 mM colchicine into the motor nerve and after denervation. Results showed that effects of drug-induced axoplasmic transport blockage differ from those of denervation as to quantitative changes in the protein concentration of certain bands. Results point to the conclusion that axoplasmic transport is involved in the neural control of a number of muscle proteins. This does not invalidate the participation of acetylcholine and muscle activity in the regulation of muscle metabolism.
Fernandez
H L
HL
Laboratory of Neurophysiology, Gabriela G. Gildemeister, Catholic University of Chile, Santiago Chile.
Ramirez
B U
BU