Genome-wide association study identifies five susceptibility loci for glioma.
To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.
Shete
Sanjay
S
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Hosking
Fay J
FJ
Robertson
Lindsay B
LB
Dobbins
Sara E
SE
Sanson
Marc
M
Malmer
Beatrice
B
Simon
Matthias
M
Marie
Yannick
Y
Boisselier
Blandine
B
Delattre
Jean-Yves
JY
Hoang-Xuan
Khe
K
El Hallani
Soufiane
S
Idbaih
Ahmed
A
Zelenika
Diana
D
Andersson
Ulrika
U
Henriksson
Roger
R
Bergenheim
A Tommy
AT
Feychting
Maria
M
Lönn
Stefan
S
Ahlbom
Anders
A
Schramm
Johannes
J
Linnebank
Michael
M
Hemminki
Kari
K
Kumar
Rajiv
R
Hepworth
Sarah J
SJ
Price
Amy
A
Armstrong
Georgina
G
Liu
Yanhong
Y
Gu
Xiangjun
X
Yu
Robert
R
Lau
Ching
C
Schoemaker
Minouk
M
Muir
Kenneth
K
Swerdlow
Anthony
A
Lathrop
Mark
M
Bondy
Melissa
M
Houlston
Richard S
RS
D000483:Alleles; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005910:Glioma / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015203:Reproducibility of Results