Langerhans cell migration: not necessarily always at the center of the skin sensitization universe.
Since their discovery in 1868, the role of Langerhans cells (LCs) in skin immunity has been researched extensively. Recent data deriving from transgenic animals that are deficient in LCs have begun to challenge the dogma that there is a universal requirement for these cells in the development of skin sensitization. This Commentary addresses relationships between LC mobilization, draining lymph node activation, and skin sensitization using immunomodulators agonistic for a family of sphingosine-1-phosphate (S1P) receptors.
Kimber
Ian
I
Faculty of Life Sciences, University of Manchester, Manchester, UK. ian.kimber@manchester.ac.uk
Cumberbatch
Marie
M
Dearman
Rebecca J
RJ
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D017449:Dermatitis, Allergic Contact / Q000517:prevention & control*; D000068876:Fingolimod Hydrochloride; D006801:Humans; D007801:Langerhans Cells / Q000187:drug effects / Q000502:physiology*; D008246:Lysophospholipids / Q000494:pharmacology*; D011409:Propylene Glycols / Q000494:pharmacology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology
D008246:Lysophospholipids; D011409:Propylene Glycols; C060506:sphingosine 1-phosphate; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine