title: [Markers of endothelial function in hypothyroidism].
abstract: The role of the endothelium in human disease has become the focus of scientific investigation and recently noninvasive and less expensive measures of endothelial function have become available. The endothelium modulates the vascular tonus and participates in inflammatory processes, platelet aggregation and thrombosis. Consequently, endothelial dysfunction has been implicated as an important event in the pathogenesis of atherosclerosis. Hypothyroidism is associated with an increased cardiovascular risk, and the assessment of endothelial function holds a great deal of promise as an assessment tool for the detection of preclinical cardiovascular alterations associated with thyroid dysfunction. Some recent studies have demonstrated a relationship between thyroid status and endothelial function, but large multicenter, placebo-controlled prospective trials are necessary to address this issue and the effect of levothyroxine replacement treatment in endothelial function. The objective of this work is to discuss the perspective picture in endothelium and thyroid function relationship.
authors: Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho (HUCFF), Departamentode Clínica Médica, Faculdadede Medicina, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil. mdcabral@globo.com
authors: Mônica Dias
authors: MD
authors: Cabral
authors: Patrícia de Fátima Santos
authors: Pde F
authors: Teixeira
authors: Sandra Pereira
authors: SP
authors: Leite
authors: Mário
authors: M
authors: Vaisman
mesh_terms: D050197:Atherosclerosis / Q000209:etiology*; D015415:Biomarkers / Q000032:analysis; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000503:physiopathology*
chemical_list: D015415:Biomarkers