title: Rolloamides A and B, cytotoxic cyclic heptapeptides isolated from the Caribbean marine sponge Eurypon laughlini.
abstract: Two cyclic heptapeptides, rolloamides A (1) and B (2), have been isolated from the Dominican marine sponge Eurypon laughlini. The structures of 1 and 2 were elucidated by a combination of spectroscopic analyses and chemical degradation. Rolloamide A (1), which was found to exist as two distinct conformers in C(5)D(5)N, exhibits growth suppressive activity against a panel of histologically diverse cancer cell lines.
authors: Department of Chemistry, University of British Columbia, Vancouver, B.C., Canada.
authors: David E
authors: DE
authors: Williams
authors: Ker
authors: K
authors: Yu
authors: Hans W
authors: HW
authors: Behrisch
authors: Rob
authors: R
authors: Van Soest
authors: Raymond J
authors: RJ
authors: Andersen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017691:Caribbean Region; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C543624:rolloamide A; C543625:rolloamide B