High pregnancy weight gain and risk of excessive fetal growth.
OBJECTIVE
The purpose of this study was too assess whether prepregnancy body mass index (BMI) modifies the relationship between pregnancy weight gain and large for gestational age (LGA; > 90% of birthweight for gestational age) or macrosomia (>or= 4500 g).


METHODS
This was a population-based cohort study of 104,980 singleton, term births from 2000-2005.


RESULTS
Prepregnancy BMI modified the relationship between weight gain and LGA. Lean women had higher odds of LGA than overweight or obese women for weight gain >or= 36 lb. For macrosomia, prepregnancy BMI did not modify the association. Compared with women who gained 15-25 lb, the aOR for a gain of 26-35 lb was 1.5 (95% confidence interval [CI], 1.2-1.9), for a gain of 36-45 lb was 2.1 (95% CI, 1.7-2.7), and for a gain of >or= 46 lb was 3.9 (95% CI, 3.0-5.0).


CONCLUSIONS
Current pregnancy weight gain recommendations include weight gain ranges that are associated with increased risk of LGA and macrosomia.
Dietz
Patricia M
PM
Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Callaghan
William M
WM
Sharma
Andrea J
AJ
D000328:Adult; D015992:Body Mass Index; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D011247:Pregnancy; D018570:Risk Assessment; D012307:Risk Factors; D012959:Socioeconomic Factors; D015430:Weight Gain