Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) in atherogenesis: a brief review.
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that primarily binds and regulates oxidized low-density lipoprotein (LDL). Expression of LOX-1 is regulated by a feed-forward system stimulated by oxidized LDL (oxLDL), a major component of atherosclerosis. LOX-1 is a homodimer with a reactive backbone that can bind to a host of different ligands, including small molecules, and whole cells. LOX-1 is involved in many intercellular, intracellular, and molecular processes that are atherogenic. LOX-1 levels are elevated within atherosclerotic plaques and its expression is induced by proinflammatory cytokines. The ability of LOX-1 to bind many different ligands and control several atherogenic processes makes this receptor a likely vascular disease biomarker as well as an ideal choice for drug therapy aimed at preventing cardiovascular disease.
Reiss
Allison B
AB
Vascular Biology Institute, Department of Medicine, Winthrop-University Hospital, Suite 502, Mineola, NY 11501, USA. AReiss@winthrop.org
Anwar
Kamran
K
Wirkowski
Peter
P
D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000209:etiology*; D004195:Disease Models, Animal; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D051379:Mice; D011110:Polymorphism, Genetic; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D051127:Scavenger Receptors, Class E / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D008077:Lipoproteins, LDL; D017382:Reactive Oxygen Species; D051127:Scavenger Receptors, Class E; C099252:oxidized low density lipoprotein