title: DNA damage in response to an Ironman triathlon.
abstract: The major aims of this study were to investigate the effect of an Ironman triathlon on DNA migration in the single cell gel electrophoresis assay, apoptosis and necrosis in the cytokinesis-block micronucleus cytome assay with lymphocytes and on changes of total antioxidant capacity in plasma. Blood samples were taken 2 days (d) before, within 20 min, 1 d, 5 d and 19 d post-race. The level of strand breaks decreased (p<0.05) immediately after the race, then increased (p<0.01) 1 d post-race and declined (p<0.01) until 19 d post-race. Apoptotic and necrotic cells decreased (p<0.01) and the total antioxidant status increased (p<0.01) immediately after the race. The results indicate that ultra-endurance exercise does not cause prolonged DNA damage in well-trained male athletes.
authors: Department of Nutritional Sciences, University of Vienna, Vienna, Austria.
authors: Stefanie
authors: S
authors: Reichhold
authors: Oliver
authors: O
authors: Neubauer
authors: Christine
authors: C
authors: Hoelzl
authors: Barbara
authors: B
authors: Stadlmayr
authors: Judit
authors: J
authors: Valentini
authors: Franziska
authors: F
authors: Ferk
authors: Michael
authors: M
authors: Kundi
authors: Siegfried
authors: S
authors: Knasmüller
authors: Karl-Heinz
authors: KH
authors: Wagner
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage; D017209:Apoptosis; D001205:Ascorbic Acid / Q000008:administration & dosage; D001642:Bicycling / Q000502:physiology*; D002245:Carbon Dioxide / Q000097:blood; D003163:Competitive Behavior; D004249:DNA Damage; D005080:Exercise Test; D006339:Heart Rate; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D009336:Necrosis; D010084:Oxidation-Reduction; D010100:Oxygen / Q000097:blood; D012119:Respiration; D012420:Running / Q000502:physiology*; D012494:Sampling Studies; D013550:Swimming / Q000502:physiology*; D024502:alpha-Tocopherol / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D007773:Lactates; D002245:Carbon Dioxide; D024502:alpha-Tocopherol; D001205:Ascorbic Acid; D010100:Oxygen