Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder.
OBJECTIVE
In the present study, we investigate the association between the val66met polymorphism of the brain-derived neurotrophic factor (BNDF) and the performance on the Wisconsin Card Sorting Test in a sample of Caucasian Brazilian patients with bipolar disorder.


METHODS
Sixty-four patients with bipolar disorder were assessed and their performance on the Wisconsin Card Sorting Test was compared with the allele frequency and genotype of the val66met polymorphism of the brain-derived neurotrophic factor.


RESULTS
The percentage of non-perseverative errors was significantly higher among patients with the val/val genotype. There was no association between (BNDF) genotype frequency and other Wisconsin Card Sorting Test domains.


CONCLUSIONS
Our results did not replicate previous descriptions of an association between a worse cognitive performance and the presence of the met allele of the val66met brain-derived neurotrophic factor gene polymorphism.
Tramontina
Juliana Fernandes
JF
Bipolar Disorder Program, Molecular Psychiatry Laboratory, INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Yates
Denise
D
Magalhães
Pedro Vieira da Silva
PV
Trentini
Clarissa
C
Sant'anna
Márcia Kauer
MK
Fries
Gabriel Rodrigo
GR
Bock
Hugo
H
Saraiva-Pereira
Maria Luiza
ML
Kapczinski
Flávio
F
D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D001938:Brazil / Q000453:epidemiology; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics
D019208:Brain-Derived Neurotrophic Factor