title: A functional role for adult hippocampal neurogenesis in spatial pattern separation.
abstract: The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation-the formation of distinct and orthogonal representations of mnemonic information-and also undergoes neurogenesis throughout life. How neurogenesis contributes to hippocampal function is largely unknown. Using adult mice in which hippocampal neurogenesis was ablated, we found specific impairments in spatial discrimination with two behavioral assays: (i) a spatial navigation radial arm maze task and (ii) a spatial, but non-navigable, task in the mouse touch screen. Mice with ablated neurogenesis were impaired when stimuli were presented with little spatial separation, but not when stimuli were more widely separated in space. Thus, newborn neurons may be necessary for normal pattern separation function in the DG of adult mice.
authors: Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors: C D
authors: CD
authors: Clelland
authors: M
authors: M
authors: Choi
authors: C
authors: C
authors: Romberg
authors: G D
authors: GD
authors: Clemenson
authors: A
authors: A
authors: Fragniere
authors: P
authors: P
authors: Tyers
authors: S
authors: S
authors: Jessberger
authors: L M
authors: LM
authors: Saksida
authors: R A
authors: RA
authors: Barker
authors: F H
authors: FH
authors: Gage
authors: T J
authors: TJ
authors: Bussey
mesh_terms: D000818:Animals; D003463:Cues; D018891:Dentate Gyrus / Q000166:cytology / Q000502:physiology*; D004193:Discrimination Learning / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D018782:Maze Learning; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D055495:Neurogenesis; D009474:Neurons / Q000502:physiology*; D011597:Psychomotor Performance; D013028:Space Perception