[Pregnancy outcome in a group of Cameroonian women with uterine fibroids].
BACKGROUND
Uterine fibroids are the most common benign tumor seen in women at reproductive age. The association of pregnancy and uterine fibroids is about 0.5 to 4%.


METHODS
In order to evaluate the complications of this association in our milieu, we carried out this prospective study. The main objective was to compare the incidence of complications of pregnancy and delivery in two groups of women: group 1 (women with uterine fibroids) and group 2 (women without fibroids). They were matched (ratio 1/1) on women age (plus or minus one), gestational age, gravidity (plus or minus one) and parity.


RESULTS
Eighty patients in each group 1 were recruited. The mean age was 31.2 years in group 1 and 30.8 years in group 2. Degeneration of fibroids occurred in 15% of cases. The incidence of threatened abortion (51.3% versus 18.8%; RR: 2.7 [1.7-4.5]; p=0.00002), threaten premature delivery (26.3% versus 10%; RR: 2.6 [1.2-5.6]; p=0.008), premature delivery (22.5% versus 7.9%; RR: 2.9 [1.2-6.9]), tocolytic treatment (48.8% versus 20.0%; RR: 2.4 [1.5-4.0]; p=0.0001) and Caesarean section (40% versus 13.8%; RR: 3.1 [1.6-5.9]; p=0.0001) were significantly increased in group 1 than in group 2. We also noticed a moderate increased of the incidence of abortions (11.3% versus 5%; RR: 2.3 [0.7-7.0]), breech presentation (11.3% versus 5%; p=0.3); however, the difference was not statistically significant in two groups.


CONCLUSIONS
We concluded that pregnancy in women with uterine fibroids is a high-risk pregnancy and needs a particular follow-up.
Tchente Nguefack
C
C
Service de gynécologie et obstétrique, hôpital Général, BP 4312, Douala, Cameroon. cnguefack2007@yahoo.fr
Fogaing
A D
AD
Tejiokem
M C
MC
Nana Njotang
P
P
Mbu
R
R
Leke
R
R
D000033:Abortion, Threatened / Q000453:epidemiology; D000328:Adult; D002163:Cameroon; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000150:complications / Q000453:epidemiology*; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology; D011446:Prospective Studies; D015149:Tocolytic Agents / Q000627:therapeutic use; D014594:Uterine Neoplasms / Q000150:complications / Q000453:epidemiology*
D015149:Tocolytic Agents