title: Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors.
abstract: A variety of novel aminoheterocycle scaffolds as selective monoamine reuptake inhibitors have been prepared and one of these scaffolds is achiral. The main elements responsible for hERG channel, CYP2D6 and CYP3A4 inhibition were identified.
authors: Roche Palo Alto LLC, Palo Alto, CA 94304, USA. matthew.lucas@roche.com
authors: Matthew C
authors: MC
authors: Lucas
authors: David S
authors: DS
authors: Carter
authors: Hai-Ying
authors: HY
authors: Cai
authors: Eun Kyung
authors: EK
authors: Lee
authors: Ryan C
authors: RC
authors: Schoenfeld
authors: Sandra
authors: S
authors: Steiner
authors: Marzia
authors: M
authors: Villa
authors: Robert J
authors: RJ
authors: Weikert
authors: Pravin S
authors: PS
authors: Iyer
mesh_terms: D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism; D065692:Cytochrome P-450 CYP3A Inhibitors; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism; D014179:Neurotransmitter Uptake Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D065690:Cytochrome P-450 CYP2D6 Inhibitors; D065692:Cytochrome P-450 CYP3A Inhibitors; D006571:Heterocyclic Compounds; D014179:Neurotransmitter Uptake Inhibitors; D019389:Cytochrome P-450 CYP2D6; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human