How subchronic and chronic health effects can be neglected for GMOs, pesticides or chemicals.
Chronic health effects are increasing in the world such as cancers, hormonal, reproductive, nervous, or immune diseases, even in young people. During regulatory toxicological subchronic tests to prevent these on mammalian health, prior commercialization of chemicals, including pesticides and drugs, or GMOs, some statistically significant findings may be revealed. This discussion is about the need to investigate the relevant criteria to consider those as biologically significant. The sex differences and the non linear dose or time related effects should be considered in contrast to the claims of a Monsanto-supported expert panel about a GMO, the MON 863 Bt maize, but also for pesticides or drugs, in particular to reveal hormone-dependent diseases and first signs of toxicities.
Séralini
Gilles-Eric
GE
University of Caen, Institute of Biology, Biochemistry, Esplanade de la Paix, 14032 Caen Cedex, France. criigen@unicaen.fr
de Vendômois
Joël Spiroux
JS
Cellier
Dominique
D
Sultan
Charles
C
Buiatti
Marcello
M
Gallagher
Lou
L
Antoniou
Michael
M
Dronamraju
Krishna R
KR
D000818:Animals; D015386:Hazardous Substances / Q000633:toxicity*; D006801:Humans; D030781:Organisms, Genetically Modified; D010575:Pesticides / Q000633:toxicity*; D012727:Sex Characteristics; D036401:Toxicity Tests, Chronic
D015386:Hazardous Substances; D010575:Pesticides