Non-modular polyketide synthases in myxobacteria.
Myxobacteria are prolific producers of a wide variety of secondary metabolites. The vast majority of these compounds are complex polyketides which are biosynthesised by multimodular polyketide synthases (PKSs). In contrast, few myxobacterial metabolites isolated to date are derived from non-modular PKSs, in particular type III PKSs. This review reports our progress on the characterisation of type III PKSs in myxobacteria. We also summarize current knowledge on bacterial type III PKSs, with a special focus on the evolutionary relationship between plant and bacterial enzymes. The biosynthesis of a quinoline alkaloid in Stigmatella aurantiaca by a non-modular PKS is also discussed.
Li
Yanyan
Y
Department of Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.
Müller
Rolf
R
D015394:Molecular Structure; D009231:Myxococcales / Q000201:enzymology* / Q000378:metabolism; D048630:Polyketide Synthases / Q000145:classification / Q000378:metabolism*; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism
D011804:Quinolines; C052094:aurachin A; D048630:Polyketide Synthases