title: Allogeneic stem cell transplantation for myelodysplastic syndromes in children: a report from the Spanish Working Party for Blood and Marrow Transplantation in Children (GETMON).
abstract: BACKGROUND
  Experience with the use of allogeneic hemopoietic stem transplantation (AHSCT) in pediatric myelodisplastic syndrome (MDS) in Spain is reviewed.
  
  
  METHODS
  Twenty-four children with MDS were analyzed retrospectively. Median age of the patients was 10 years. Twenty patients received a bone marrow graft and 4 an unrelated cord blood (UCB) transplant; 12 bone marrow grafts were from a matched related donor (MRD) and 8 from a matched unrelated donor (MUD). Conditioning regimen consisted of chemotherapy alone in 17 patients (busulfan and cyclophosphamide +/- melfalan) Seven patients received TBI and cyclophosphamide.
  
  
  RESULTS
  Ten patients died from transplant-related toxicity and 4 had relapse or disease progression post-AHSCT. Nine patients are alive and event-free with a median follow-up of 120 months. EFS rate in the MRD group was 0.48 (SE 0.13) versus 0.25 (SE 0.12) in the MUD/UCB group (p = .07). Lansky score in survivors is >or=90%.
  
  
  CONCLUSIONS
  In this historical series of children with MDS, in spite of severe transplant-related toxicity, encouraging EFS outcomes have been achieved after AHSCT with good quality of life.
authors: Department of Pediatrics, Hospital Ramon y Cajal-University of Alcalá, Madrid, Spain. amvillatv@yahoo.es
authors: Arturo
authors: A
authors: Muñoz
authors: Cristina
authors: C
authors: Díaz-Heredia
authors: Isabel
authors: I
authors: Badell
authors: Encarna
authors: E
authors: Bureo
authors: Pedro
authors: P
authors: Gómez
authors: Ana
authors: A
authors: Martínez
authors: Amparo
authors: A
authors: Verdeguer
authors: José María
authors: JM
authors: Pérez-Hurtado
authors: Rafael
authors: R
authors: Fernández-Delgado
authors: Marta
authors: M
authors: González-Vicent
authors: María Soledad
authors: MS
authors: Maldonado
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology / Q000517:prevention & control*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000276:immunology / Q000401:mortality / Q000601:surgery*; D011788:Quality of Life; D012189:Retrospective Studies; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous / Q000276:immunology*; D016896:Treatment Outcome