Application of depression criteria (DSM-IV) in patients with Parkinson's disease.
BACKGROUND
The aim of this study is to analyze the clinical differences between Parkinson's disease patients with major (MD) and minor depression (md) and to see how both affect the quality of life.


METHODS
118 patients diagnosed with Parkinson's disease. The mean age of onset was 60.4+/-11.2 years with a mean duration of 8.5+/-6.2 years. Depression was diagnosed according to DSM-IV-TR criteria. Scores on the Hamilton depression inventory, MMSE, PDQ-39, NPI-10, UPDRS III, and UPDRS IV were recorded.


RESULTS
Twenty-one patients (17.8%) met the criteria of major depression (MD) and 33 (28.0%) those of minor depression (md). The scores on the PDQ-39 and NPI-10 of patients with MD were higher than in patients with md, and control group. The MMSE scores were lower in patients with MD. In 52.2% of the patients with MD, the diagnosis of depression was made prior to that of PD, this occurred only in 24.2% of the patients with md (p<0.001). The presence of anhedonia was related to cognitive impairment and the presence of neuropsychiatric symptoms.


CONCLUSIONS
MD is probably a part of the disease process of PD; it is associated with cognitive impairment and may precede motor symptoms.
Gómez-Esteban
Juan Carlos
JC
Movement Disorders Unit, Department of Neurology, Hospital of Cruces, Baracaldo Vizcaya, Osakidetza-Servicio Vasco de Salud, Spain. jgomeze@meditex.es
Tijero
Beatriz
B
Somme
Johanne
J
Bilbao
Iker
I
Fernández
Julen
J
Boyero
Sabas
S
Velasco
Fernando
F
Lezcano
Elena
E
Zarranz
J J
JJ
D000368:Aged; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000150:complications / Q000175:diagnosis*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric