title: [Prognostic analysis of 669 liver metastasis of colorectal cancer cases].
abstract: OBJECTIVE
  To evaluate the relation between different therapy and survival rate of liver metastasis of colorectal cancer (LMCC).
  
  
  METHODS
  Clinical data of 669 LMCC patients,collected from Fudan University Zhongshan Hospital from January 2000 to July 2008, were analyzed retrospectively.
  
  
  RESULTS
  Of the 669 cases, 379 cases were synchronous liver metastases(SLM) and 290 cases were metachronous liver metastases(MLM). There were no significant differences in age, gender and position of primary tumor between SLM and MLM groups(P>0.05), but as to liver metastasis characteristics(liver lobe involved, focus number and maximal focus diameter) and CEA, CA19-9 before therapy,there were significant differences(P<0.05). Two hundred and fifty-three cases underwent curative hepatic resection, including 123 cases in SLM and 130 cases in MLM. Until October 31, 2008, all the cases were followed up. The median survival time of SLM was(11+/-1) months and of MLM(23+/-2) months(P<0.01). Five-year survival rate of SLM was 6.4% and of MLM 11.4%(P<0.01). As to different treatments, median survival time and 5-year survival rate of curative hepatic resection group were 37 months and 35.6%, and of non-operation groups(i.e. intervention, chemotherapy, radiofrequency therapy and percutaneous ethanol injection) were 5 to 26 months and 0 to 3.6% respectively(P<0.05).
  
  
  CONCLUSIONS
  Curative hepatic resection is the first choice of liver metastasis of colorectal cancer, which can improve the survival rate. Resection rate and survival of MLM are better than those of SLM.
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Li
authors: L
authors: Ren
authors: Shi-xu
authors: SX
authors: Lv
authors: Yun-shi
authors: YS
authors: Zhong
authors: Jian-min
authors: JM
authors: Xu
authors: Ye
authors: Y
authors: Wei
authors: Jia
authors: J
authors: Fan
authors: Lun-xiu
authors: LX
authors: Qin
authors: Jian-hua
authors: JH
authors: Wang
authors: Jie-min
authors: JM
authors: Cheng
authors: Sheng
authors: S
authors: Qian
authors: Xin-yu
authors: XY
authors: Qin
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate