title: Regional distribution of high-affinity L-tryptophan uptake in rat brain.
abstract: L-tryptophan is accumulated by slices of seven regions of the rat brain in a saturable, energy-depending fashion, with K(m)-values ranging from 53 to 142 muM. The maximal number of L-tryptophan accumulating sites differs only by about two-fold for the brain regions investigated. The regional distribution of the high-affinity L-tryptophan uptake does not correlate with the amount of serotonin synaptosomal uptake and apparent receptor binding. It is assumed that a specific role of the L-tryptophan uptake system within the serotoninergic system in the brain is questionable.
authors: Pharmakologisches Institut der Universität Mainz, Obere Zahlbacher Str. 67, D-6500 Mainz G.F.R.
authors: S H
authors: SH
authors: Höckel
authors: W E
authors: WE
authors: Müller
authors: U
authors: U
authors: Wollert