Magnetic resonance imaging of tablet dissolution.
Magnetic resonance imaging (MRI) is the technique of choice for measuring hydration, and its effects, during dissolution of tablets since it non-invasively maps (1)H nuclei associated with 'mobile' water. Although most studies have used MRI systems with high-field superconducting magnets, low-field laboratory-based instruments based on permanent magnet technology are being developed that provide key data for the formulation scientist. Incorporation of dissolution hardware, in particular the United States Pharmacopeia (USP) apparatus 4 flow-through cell, allows measurements under controlled conditions for comparison against other dissolution methods. Furthermore, simultaneous image acquisition and measurement of drug concentration allow direct comparison of the drug release throughout the hydration process. The combination of low-field MRI with USP-4 apparatus provides another tool to aid tablet formulation.
Nott
Kevin P
KP
Oxford Instruments Magnetic Resonance, Oxon, United Kingdom. kevin.nott@oxinst.com
D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D005079:Excipients / Q000737:chemistry; D007700:Kinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012995:Solubility; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods; D014867:Water / Q000032:analysis
D005079:Excipients; D004364:Pharmaceutical Preparations; D013607:Tablets; D014867:Water