title: [Gastric perforation associated with Candida infection].
abstract: Notable causes of gastroduodenal ulcer are Helicobacter pylori infection, intake of non-steroidal anti-inflammatory agents, neoplastic disease, acid hypersecretory states and secondary peptic ulcer disease. There are case reports of healthy patients or those with risk factors for fungal infection who develop gastroduodenal ulcer perforation associated with the presence of fungi in ascitic fluid or gastroduodenal ulcer tissue but without the above-mentioned etiological factors. Thus, other factors and pathogens may be involved in the pathogenesis of perforation. The use of antifungal agents in patients following surgery for a perforated gastroduodenal ulcer is controversial. We report two cases of healthy patients who underwent surgery for perforated gastroduodenal ulcer, in whom the most frequent causes of perforation were excluded. Only the presence of Candida in the ulcer was found.
authors: Servicio de Cirugía General y Digestiva, Hospital de la Santa Creu i Sant Pau, Universidad Autónoma de Barcelona, Barcelona, España. JBollo@santpau.es
authors: Jesús
authors: J
authors: Bollo
authors: Elena
authors: E
authors: Carrilo
authors: Ion
authors: I
authors: Lupu
authors: Ferran
authors: F
authors: Caballero
authors: Manel
authors: M
authors: Trias
mesh_terms: D002177:Candidiasis / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000382:microbiology*; D013276:Stomach Ulcer / Q000382:microbiology*; D055815:Young Adult