title: The prophylactic effect of rectal acetaminophen on postoperative pain and opioid requirements after adenotonsillectomy in children.
abstract: BACKGROUND
  Postoperative pain in children is common after adenotonsillectomy. Rectal acetaminophen has been used effectively for postoperative pain management in small children. The aim of this randomized double blind study was to evaluate the prophylactic effect of rectal acetaminophen on postoperative pain management and opioid requirements in children undergoing adenotonsillectomy.
  
  
  METHODS
  104 children, 7 to 15 yr, ASA I or II scheduled for elective adenotonsillectomy were recruited for the study. Patients were randomized to receive either rectal acetaminophen 40 mg/kg or nothing after induction of standard anesthesia. The postoperative pain was assessed using visual analog scale (VAS) every 2 hours for the first 6 hours. The need for rescue analgesic, intravenous pethedine of 0.5 mg/kg, was recorded at 24 hours after surgery.
  
  
  RESULTS
  Pain scores were significantly lower in acetaminophen group at different times (p<0.001) and needed less rescue analgesic (p<0.001).
  
  
  CONCLUSIONS
  We conclude that prophylactic rectal acetaminophen is effective in reducing pain after adenotonsillectomy and postoperative analgesic requirement.
authors: Zahedan Univ. of Medical Sciences, Zahedan, Iran.
authors: Gholam Ali
authors: GA
authors: Dashti
authors: Shahram
authors: S
authors: Amini
authors: Elham
authors: E
authors: Zanguee
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use*; D000233:Adenoidectomy / Q000009:adverse effects*; D000285:Administration, Rectal; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000627:therapeutic use; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008614:Meperidine / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D013488:Suppositories; D014068:Tonsillectomy / Q000009:adverse effects*
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D013488:Suppositories; D000082:Acetaminophen; D008614:Meperidine