Electrophysiological findings in patients with isolated left ventricular non-compaction.
OBJECTIVE
Patients with isolated left ventricular non-compaction (IVNC) are at high risk for developing ventricular tachyarrhythmias. However, no analysis of invasive electrophysiological (EP) findings in these patients has yet been performed.


RESULTS
We performed a retrospective analysis of EP findings in 24 patients with IVNC. Ventricular tachyarrhythmias were inducible in nine patients; of these, two patients had sustained monomorphic ventricular tachycardia (VT) and two patients had ventricular fibrillation. No specific electrocardiographic or echocardiographic finding was predictive of VT inducibility. Three of the 9 patients with inducible VT experienced ventricular tachyarrhythmias during the follow-up of 61.4+/-50 months, whereas no tachyarrhythmias or sudden deaths were noted in 12 patients without inducible VT during the follow-up of 30+/-19 months (3 patients in the latter group were lost to follow-up). Supraventricular tachyarrhythmias were inducible in seven patients.


CONCLUSIONS
Our present study provides the first comprehensive analysis of EP findings in patients with IVNC. Ventricular and supraventricular arrhythmias can readily be induced in these patients, whereas the inducibility of a sustained monomorphic VT is relatively low. Further studies including long-term follow-up are required to investigate the role of EP testing for arrhythmic risk stratification in these patients.
Steffel
Jan
J
Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich, and Center for Integrative Human Physiology, University of Zurich, Rämistrasse 100, CH-8091 Zürich, Switzerland.
Kobza
Richard
R
Namdar
Mehdi
M
Wolber
Thomas
T
Brunckhorst
Corinna
C
Lüscher
Thomas F
TF
Jenni
Rolf
R
Duru
Firat
F
D000293:Adolescent; D000328:Adult; D009202:Cardiomyopathies / Q000150:complications* / Q000175:diagnosis*; D004562:Electrocardiography / Q000379:methods*; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017180:Tachycardia, Ventricular / Q000150:complications* / Q000175:diagnosis*; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000175:diagnosis*; D055815:Young Adult