title: Single-shot two-dimensional full-range optical coherence tomography achieved by dispersion control.
abstract: We present a full-range Fourier-domain optical coherence tomography (OCT) system that is capable of acquiring two-dimensional images of living tissue in a single shot. By using line illumination of the sample in combination with a two-dimensional imaging spectrometer, 1040 depth scans are performed simultaneously on a sub-millisecond timescale. Furthermore, we demonstrate an easy and flexible real-time single-shot technique for full-range (complex-conjugate cancelled) OCT imaging that is compatible with both two-dimensional as well as ultrahigh-resolution OCT. By implementing a dispersion imbalance between reference and sample arms of the interferometer, we eliminate the complex-conjugate signal through numerical dispersion compensation, effectively increasing the useful depth range by a factor of two. The system allows us to record 6.7 x 3.2 mm images at 5 microm depth resolution in 0.2 ms. Data postprocessing requires only 4 s. We demonstrate the capability of our system by imaging the anterior chamber of a mouse eye in vitro, as well as human skin in vivo.
authors: Department of Physics and Astronomy, Faculty of Sciences, VU University, Amsterdam, The Netherlands. switte@few.vu.nl
authors: S
authors: S
authors: Witte
authors: M
authors: M
authors: Baclayon
authors: E J G
authors: EJ
authors: Peterman
authors: R F G
authors: RF
authors: Toonen
authors: H D
authors: HD
authors: Mansvelder
authors: M L
authors: ML
authors: Groot
mesh_terms: D000465:Algorithms; D000818:Animals; D004867:Equipment Design; D005123:Eye / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007368:Interferometry / Q000379:methods; D007834:Lasers; D051379:Mice; D016011:Normal Distribution; D055095:Optics and Photonics; D012542:Scattering, Radiation; D012867:Skin / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*