title: Tumor necrosis factor alpha and interleukin 10 promoter polymorphisms in Mexican patients with restenosis after coronary stenting.
abstract: To test for an association with risk for restenosis after coronary stent placement, the TNF-alpha and IL-10 polymorphisms were analyzed by 5' exonuclease TaqMan assays in 162 patients who initially underwent coronary stenting. Analysis of basal and procedure coronary angiographies revealed a higher proportion of restenosis in lesions treated with bare metal stents compared with those treated with drug-eluting stents (P < 0.001). Distribution of TNF-alpha genotypes was similar in patients with and without restenosis. The IL-10 polymorphisms showed a moderate protective trend of the -819 TT genotype against restenosis when the lesions were analyzed (P = 0.071, OR = 0.471). Multivariate analysis confirmed a protective role for drug-eluting stents (P < 0.001, OR = 0.199) and the -819 TT genotype (P = 0.037, OR = 0.391). These results suggest the IL-10 -819 TT genotype has a protective role against in-stent restenosis.
authors: Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors: Marco Antonio
authors: MA
authors: Martínez-Ríos
authors: Marco Antonio
authors: MA
authors: Peña-Duque
authors: José Manuel
authors: JM
authors: Fragoso
authors: Hilda
authors: H
authors: Delgadillo-Rodríguez
authors: José Manuel
authors: JM
authors: Rodríguez-Pérez
authors: Emma
authors: E
authors: Miranda-Malpica
authors: David
authors: D
authors: Cruz-Robles
authors: María Magdalena
authors: MM
authors: Cavazos-Quero
authors: Luis Gerardo
authors: LG
authors: Rodríguez-Lobato
authors: Gilberto
authors: G
authors: Vargas-Alarcón
mesh_terms: D044467:American Indian or Alaska Native / Q000235:genetics*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology; D011401:Promoter Regions, Genetic / Q000235:genetics*; D015607:Stents / Q000009:adverse effects*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10