title: Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity.
abstract: OBJECTIVE
  Fish-oil contains high concentrations of omega-3 fatty acids that have been shown to have anti-inflammatory properties. We have evaluated the effects of purified omega-3 fatty acid supplements on several anthropometric and biochemical parameters, including heat shock protein (Hsp) 27 antibody titres in subjects with metabolic syndrome.
  
  
  METHODS
  Subjects (n = 120) with metabolic syndrome (mean age of 52.9 +/- 11.9 years) were randomly allocated to one of two groups: sixty subjects were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period.
  
  
  RESULTS
  The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group.
  
  
  CONCLUSIONS
  It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity.
authors: Heart and Vascular Research Centre, Avicenna (Bu-Ali) Research Institute, MUMS, Mashhad, Iran.
authors: Mahmoud
authors: M
authors: Ebrahimi
authors: Majid
authors: M
authors: Ghayour-Mobarhan
authors: Samaneh
authors: S
authors: Rezaiean
authors: Maryam
authors: M
authors: Hoseini
authors: Seyyed Mohamad Reza
authors: SM
authors: Parizade
authors: Fatemeh
authors: F
authors: Farhoudi
authors: Syyed Javad
authors: SJ
authors: Hosseininezhad
authors: Shima
authors: S
authors: Tavallaei
authors: Amirhosein
authors: A
authors: Vejdani
authors: Mohsen
authors: M
authors: Azimi-Nezhad
authors: Mohamad Taghi
authors: MT
authors: Shakeri
authors: Mina Akbari
authors: MA
authors: Rad
authors: Naser
authors: N
authors: Mobarra
authors: Seyyed Mohammad Reza
authors: SM
authors: Kazemi-Bajestani
authors: Gordon A A
authors: GA
authors: Ferns
mesh_terms: D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000097:blood / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy*; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000627:therapeutic use; D015118:Eicosapentaenoic Acid / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005260:Female; D005395:Fish Oils; D055551:HSP27 Heat-Shock Proteins / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000188:drug therapy; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged; D012307:Risk Factors; D015431:Weight Loss / Q000187:drug effects / Q000502:physiology
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D055551:HSP27 Heat-Shock Proteins; D004281:Docosahexaenoic Acids; D002097:C-Reactive Protein; D015118:Eicosapentaenoic Acid