A synthetic, conformationally restricted analogue of L-glutamic acid which acts as a powerful neuronal excitant.
The activity of a synthetic compound, cis-1-aminocyclopentane-1,3-dicarboxylic acid, which possesses a conformationally very restricted molecule, has been compared with that of L-glutamic acid and a number of other compounds as a neuronal excitant. The new compound is about 10-fold more active than glutamate and its rigidity indicates that it reacts only with glutamate receptors and not with those responsive to aspartate.
McLennan
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Department of Physiology University of British Columbia Vancouver, B.C., V6T 1W5 Canada.
Wheal
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