title: Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
abstract: We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).
authors: National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. emelia@bu.edu
authors: Emelia J
authors: EJ
authors: Benjamin
authors: Kenneth M
authors: KM
authors: Rice
authors: Dan E
authors: DE
authors: Arking
authors: Arne
authors: A
authors: Pfeufer
authors: Charlotte
authors: C
authors: van Noord
authors: Albert V
authors: AV
authors: Smith
authors: Renate B
authors: RB
authors: Schnabel
authors: Joshua C
authors: JC
authors: Bis
authors: Eric
authors: E
authors: Boerwinkle
authors: Moritz F
authors: MF
authors: Sinner
authors: Abbas
authors: A
authors: Dehghan
authors: Steven A
authors: SA
authors: Lubitz
authors: Ralph B
authors: RB
authors: D'Agostino
authors: Thomas
authors: T
authors: Lumley
authors: Georg B
authors: GB
authors: Ehret
authors: Jan
authors: J
authors: Heeringa
authors: Thor
authors: T
authors: Aspelund
authors: Christopher
authors: C
authors: Newton-Cheh
authors: Martin G
authors: MG
authors: Larson
authors: Kristin D
authors: KD
authors: Marciante
authors: Elsayed Z
authors: EZ
authors: Soliman
authors: Fernando
authors: F
authors: Rivadeneira
authors: Thomas J
authors: TJ
authors: Wang
authors: Gudny
authors: G
authors: Eiríksdottir
authors: Daniel
authors: D
authors: Levy
authors: Bruce M
authors: BM
authors: Psaty
authors: Man
authors: M
authors: Li
authors: Alanna M
authors: AM
authors: Chamberlain
authors: Albert
authors: A
authors: Hofman
authors: Ramachandran S
authors: RS
authors: Vasan
authors: Tamara B
authors: TB
authors: Harris
authors: Jerome I
authors: JI
authors: Rotter
authors: W H Linda
authors: WH
authors: Kao
authors: Sunil K
authors: SK
authors: Agarwal
authors: Bruno H Ch
authors: BH
authors: Stricker
authors: Ke
authors: K
authors: Wang
authors: Lenore J
authors: LJ
authors: Launer
authors: Nicholas L
authors: NL
authors: Smith
authors: Aravinda
authors: A
authors: Chakravarti
authors: André G
authors: AG
authors: Uitterlinden
authors: Philip A
authors: PA
authors: Wolf
authors: Nona
authors: N
authors: Sotoodehnia
authors: Anna
authors: A
authors: Köttgen
authors: Cornelia M
authors: CM
authors: van Duijn
authors: Thomas
authors: T
authors: Meitinger
authors: Martina
authors: M
authors: Mueller
authors: Siegfried
authors: S
authors: Perz
authors: Gerhard
authors: G
authors: Steinbeck
authors: H-Erich
authors: HE
authors: Wichmann
authors: Kathryn L
authors: KL
authors: Lunetta
authors: Susan R
authors: SR
authors: Heckbert
authors: Vilmundur
authors: V
authors: Gudnason
authors: Alvaro
authors: A
authors: Alonso
authors: Stefan
authors: S
authors: Kääb
authors: Patrick T
authors: PT
authors: Ellinor
authors: Jacqueline C M
authors: JC
authors: Witteman
mesh_terms: D001281:Atrial Fibrillation / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D015201:Meta-Analysis as Topic; D009154:Mutation / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015203:Reproducibility of Results; D044465:White People / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins; C071660:ZFHX3 protein, human