Use of cyst fluid CEA, CA19-9, and amylase for evaluation of pancreatic lesions.
OBJECTIVE
The study goals were development of reference intervals and an interpretive algorithm for pancreatic cyst fluid tumor markers.


METHODS
442 pancreatic cyst fluids were tested for CEA, CA19-9, and amylase.


RESULTS
CEA>30 ng/mL discriminates mucinous from non-mucinous cysts. After CEA analysis, amylase and CA19-9 segregate non-mucinous and mucinous subtypes, respectively.


CONCLUSIONS
Pancreatic cyst fluid tumor markers supplement other diagnostic measures. This study provides estimated reference intervals and an algorithm for interpretation.
Snozek
Christine L H
CL
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. snozek.christine@mayo.edu
Mascarenhas
Ranjan C
RC
O'Kane
Dennis J
DJ
D000465:Algorithms; D000681:Amylases / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D018395:CA-19-9 Antigen / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D020420:Cyst Fluid / Q000737:chemistry*; D003937:Diagnosis, Differential; D010181:Pancreatic Cyst / Q000473:pathology*; D012372:ROC Curve; D012016:Reference Values
D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D000681:Amylases