title: In vivo internal diffusion of several inorganic microparticles through oral administration.
abstract: We observed the internal diffusion behavior of inorganic micro/nano particles through oral administration. By oral exposure, the fed particles were absorbed through the digestive system then reached some organs after internal diffusion in the body. For example, TiO2 particles fed to mice were detected in the lung, liver, and spleen after 10 days of feeding. Whereas, the absorption efficiency was extremely low compared with intravenous injection. In a comparison of the simple amount of administration, oral exposure required 102 times or more amount by intravenous injection for detection by an X-ray scanning analytical microscope. During dental treatment, micro/nano particles from tooth or dental materials would generate in the oral cavity, and some of the particles had a possibility to be swallowed, absorbed through the digestive system, and then diffuse into the body. However, our results suggest that biocompatible microparticles that are naturally taken orally affect animals only rarely because of the low absorption efficiency.
authors: Department of Biomedical Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan. sabe@den.hokudai.ac.jp
authors: Shigeaki
authors: S
authors: Abe
authors: Chila
authors: C
authors: Koyama
authors: Mitsue
authors: M
authors: Esaki
authors: Tsukasa
authors: T
authors: Akasaka
authors: Motohiro
authors: M
authors: Uo
authors: Yoshinori
authors: Y
authors: Kuboki
authors: Manabu
authors: M
authors: Morita
authors: Fumio
authors: F
authors: Watari
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003764:Dental Materials / Q000737:chemistry*; D004058:Diffusion; D006054:Goldfish / Q000378:metabolism; D007287:Inorganic Chemicals / Q000008:administration & dosage* / Q000737:chemistry*; D008422:Materials Testing; D008863:Microspheres; D009928:Organ Specificity; D014018:Tissue Distribution
chemical_list: D003764:Dental Materials; D007287:Inorganic Chemicals