Synthesis and vasodilatory activity of some amide derivatives of 6-(4-carboxymethyloxyphenyl)-4,5-dihydro-3(2H)-pyridazinone.
Synthesis and vasodilatory activity of some amide derivatives of 6-(4-carboxymethyloxyphenyl)-4,5-dihydro-3(2H)-pyridazinone are reported. An effect of substitution at 2-position of pyridazinone ring on vasodilatory potential has also been explored. The most active compound 6-[4-(2-oxo-2-pyrrolidin-1-yl-ethoxy)phenyl]-2-(4-fluorophenyl)-4,5-dihydropyridazin-3(2H)-one (11) exhibited vasodilating activity in nanomolar range (IC(50)=0.051 microM).
Bansal
Ranju
R
University Institute of Pharmaceutical Sciences, Panjab University, Sector 14, Chandigarh 160014, India. ranju29in@yahoo.co.in
Kumar
Dinesh
D
Carron
Rosalia
R
de la Calle
Carmen
C
D000818:Animals; D001011:Aorta / Q000187:drug effects; D005260:Female; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D006834:Hydrazines; D011724:Pyridazines; D014665:Vasodilator Agents; C029424:hydrazine