title: Anti-listerial activity and structure-activity relationships of the six major tyrocidines, cyclic decapeptides from Bacillus aneurinolyticus.
abstract: Six major tyrocidines, purified from the antibiotic tyrothricin complex produced by Bacillus aneurinolyticus, showed significant lytic and growth inhibitory activity towards the gram+ bacteria, Micrococcus luteus and Listeria monocytogenes, but not against the gram- bacterium, Escherichia coli. The isolated natural tyrocidines were in particular more active against the leucocin A (antimicrobial peptide) resistant strain, L. monocytogenes B73-MR1, than the sensitive L. monocytogenes B73 strain. Remarkably similar structure-activity trends toward the three gram+ bacteria were found between growth inhibition and different physicochemical parameters (solution amphipathicity, theoretical lipophilicity, side-chain surface area and mass-over-charge ratio).
authors: BIOPEP Peptide Group, Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa.
authors: Barbara M
authors: BM
authors: Spathelf
authors: Marina
authors: M
authors: Rautenbach
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000494:pharmacology*; D001407:Bacillus / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D008089:Listeria monocytogenes / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014440:Tyrocidine / Q000032:analysis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014440:Tyrocidine