Calculating cumulative live-birth rates from linked cycles of assisted reproductive technology (ART): data from the Massachusetts SART CORS.
OBJECTIVE
To determine the feasibility of linking assisted reproductive technology (ART) cycles for individual women to compare per-cycle and cumulative live-birth rates.


METHODS
Historical cohort study.


METHODS
Clinic-based data.


METHODS
A total of 27,906 ART cycles with residency or treatment in Massachusetts during 2004-2006 and reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) on-line database.


METHODS
None.


METHODS
Per-cycle and cumulative live-birth rates.


RESULTS
Linkage of cycles up to and including the first live-birth delivery revealed 14,265 women who averaged 1.9+/-1.2 SD cycles (range 1-11). These cycles yielded 9,452 pregnancies resulting in 7,675 live-birth deliveries. From cycle 1 to cycle 4, the cumulative live-birth rate for all patients increased from 30.4% to 43.3%, 49.1%, and 51.9%, respectively, and plateaued thereafter at about 53%. The cumulative live-birth rate after three cycles using donor oocytes was approximately 60% for women aged<43 years and >50% for women>or=43 years; for autologous oocytes it was 60.1% for ages<35 years and declined steadily to 8.5% for ages>or=43 years.


CONCLUSIONS
The results demonstrate the feasibility of linking ART cycles for individual women from SART CORS to characterize cumulative live-birth rates.
Stern
Judy E
JE
Department of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire. Electronic address: judy.e.stern@dartmouth.edu.
Brown
Morton B
MB
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Luke
Barbara
B
Department of Obstetrics, Gynecology, and Reproductive Biology and Department of Epidemiology, Michigan State University, East Lansing, Michigan.
Wantman
Ethan
E
Redshift Technologies, New York, New York.
Lederman
Avi
A
Redshift Technologies, New York, New York.
Missmer
Stacey A
SA
Department of Obstetrics and Gynecology, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
Hornstein
Mark D
MD
Center for Reproductive Medicine, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts.
D000328:Adult; D000465:Algorithms; D016208:Databases, Factual; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016247:Information Storage and Retrieval; D050498:Live Birth / Q000453:epidemiology*; D008404:Massachusetts / Q000453:epidemiology; D008597:Menstrual Cycle / Q000502:physiology; D015233:Models, Statistical; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D013997:Time Factors; D016896:Treatment Outcome