title: Plasma level of granulocyte-colony stimulating factor during granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis.
abstract: OBJECTIVE
  Cytapheresis with extra-corporeal circulation for ulcerative colitis is effective but its mechanisms are still unclear. Granulocytecolony stimulating factor (G-CSF) strongly mobilizes bone marrow-derived cells and serves as antiinflammatory factor. We investigated plasma levels of G-CSF during granulocyte and monocyte adsorptive apheresis (GCAP).
  
  
  METHODS
  Nineteen cases of ulcerative colitis were measured plasma concentration of G-CSF during the first session of GCAP therapy.
  
  
  RESULTS
  G-CSF were significantly increased in the column inflow at 30 min compared with the baseline (Wilcoxon test, p < 0.01), and also increased through the column (Wilcoxon test, p < 0.01). The ratio of the increase in the column outflow at 60 min was 1.5-fold compared with the baseline. However, we could not show a significant relation between G-CSF level and clinical efficacy.
  
  
  CONCLUSIONS
  This is the first report concerning G-CSF during CAP. G-CSF is increased due to GCAP and appears to be a candidate which should be further investigated.
authors: Division of Endoscopy, Yamagata University Hospital, Yamagata, Japan. htakeda@med.id.yamagata-u.ac.jp
authors: Hiroaki
authors: H
authors: Takeda
authors: Shoichi
authors: S
authors: Nishise
authors: Tadahisa
authors: T
authors: Fukui
authors: Shoichiro
authors: S
authors: Fujishima
authors: Tomohiko
authors: T
authors: Orii
authors: Sayaka
authors: S
authors: Otake
authors: Takeshi
authors: T
authors: Sato
authors: Yu
authors: Y
authors: Sasaki
authors: Sumio
authors: S
authors: Kawata
mesh_terms: D000327:Adsorption; D000328:Adult; D001781:Blood Component Removal; D003093:Colitis, Ulcerative / Q000097:blood* / Q000628:therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor