title: Subcutaneously implanted central venous access device infection in pediatric patients with cancer.
abstract: OBJECTIVE
  Subcutaneously implanted central venous access devices (SICVADs) are a common route of intravascular access for pediatric patients with cancer. This study was performed to evaluate the risk for SICVAD-related infection in a large consecutive series of unselected children with cancer in a single medical center.
  
  
  METHODS
  The medical charts of 209 pediatric patients with cancer who received a SICVAD from January 1, 2001 to December 31, 2005 were retrospectively reviewed, and the patients were followed-up until June 30, 2006. The demographics, clinicopathologic features, and infectious complications were collected for analysis.
  
  
  RESULTS
  There were 137,924 SICVAD days (median, 660 days; range, 16-1962 days). The rate of SICVAD-related infections was 0.15 episodes/1000 SICVAD days. There were 21 episodes of SICVAD-related infection among 17 patients, 18 were bloodstream infection among 14 patients and the other 3 were local infection among 3 patients. Sixteen SICVADs were removed, 13 were associated with bloodstream infection and 3 with local infection. Young age (<2 years) was associated with a high risk for SICVAD-related infection. Staphylococcal spp. and fungi were the most common pathogens associated with SICVADs.
  
  
  CONCLUSIONS
  The rate of SICVAD-related infection in children with cancer was low. Children younger than 2 years had a higher risk for SICVAD-related infection than older children. Fungi play an important role in SICVAD-related infection.
authors: Department of Pediatrics, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
authors: Miao-Chiu
authors: MC
authors: Hung
authors: Chun-Jen
authors: CJ
authors: Chen
authors: Keh-Gong
authors: KG
authors: Wu
authors: Giun-Yi
authors: GY
authors: Hung
authors: Yu-Jan
authors: YJ
authors: Lin
authors: Ren-Bin
authors: RB
authors: Tang
mesh_terms: D000293:Adolescent; D000367:Age Factors; D055499:Catheter-Related Infections / Q000382:microbiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000382:microbiology*; D004864:Equipment and Supplies / Q000382:microbiology*; D005260:Female; D005658:Fungi / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009369:Neoplasms / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D013210:Staphylococcus / Q000302:isolation & purification