The prevalence of abnormal liver enzymes and metabolic syndrome in obese adolescent females with polycystic ovary syndrome.
OBJECTIVE
We sought to determine the prevalence of abnormal liver enzymes suggestive of nonalcoholic steatohepatitis and metabolic syndrome in obese adolescent females with polycystic ovary syndrome.


METHODS
A retrospective chart review.


METHODS
Patients included 39 obese (body mass index Z score >/= 2) adolescent females with a diagnosis of polycystic ovary syndrome. Clinical and biochemical data in these patients were reviewed.


METHODS
Aspartate and alanine aminotransferase levels, lipid panel, blood pressure, body mass index, and glucose intolerance were the main outcome measures of the study.


RESULTS
The study showed that 15.4 % (6 of 39) of patients had elevated aminotransferase levels, suggestive of nonalcoholic steatohepatitis, and 43.6 % (17 of 39) of patients qualified as having metabolic syndrome. Finally, 10.2 % (4 of 39) of patients were found to have both liver dysfunction and metabolic syndrome.


CONCLUSIONS
Liver dysfunction consistent with nonalcoholic steatohepatitis and metabolic syndrome are prevalent in obese adolescent females with polycystic ovary syndrome. Therefore, early screening and further work-up for both disease states are warranted in cases of young adolescent females with polycystic ovary syndrome.
Barfield
Elaine
E
New York University School of Medicine, New York, New York, USA.
Liu
Ying-Hua
YH
Kessler
Marion
M
Pawelczak
Melissa
M
David
Raphael
R
Shah
Bina
B
D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001224:Aspartic Acid / Q000097:blood; D002648:Child; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008099:Liver / Q000201:enzymology*; D008111:Liver Function Tests; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000503:physiopathology; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000201:enzymology / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D012189:Retrospective Studies
D001224:Aspartic Acid; D000410:Alanine Transaminase