title: [Effects of balneotherapy on the reactants of acute inflammation phase in ankylosing spondylitis].
abstract: BACKGROUND
  Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects sacroiliac joints, spinal column and peripheral joints. Beside medication therapy, physical and balneotherapy play an important role in its complex treatment.
  
  
  OBJECTIVE
  The aim of the research was to establish serum concentrations of C-reactive protein (CRP), alpha 1-acid glycoprotein (alpha 1-AGP), ceruloplasmine (CP) and erythrocyte sedimentation rate (SE) before and after the balneotherapy in ankylosing spondylitis.
  
  
  METHODS
  The research included 50 AS patients according to the revised New York criteria, of mean age 43 years, who were treated for 14 days on the average at the Clinic for Rheumatology of the Institute "Niska Banja". All the patients received medications and balneotherapy (radioactive oligomineral baths, peloid, massage, kinesitherapy); the serum concentrations of CRP, al-AGP, CP and SE were measured before and after balneotherapy. Serum proteins were determined using original Nor Partigen plates Boehringer. Erythrocyte sedimentation rate was measured by Westergreen method. Balneotherapy was applied individually, intensively or mildly, depending on the AS stage and activity phase.
  
  
  RESULTS
  After dosed balneotherapy, a significant decrease in the concentrations of CP (p < 0.05), alpha1-AGP (p < 0.01) and CRP (p < 0.05) was registered in the serums of AS patients. ESR was not significantly reduced.
  
  
  CONCLUSIONS
  The research proved that alpha 1-acid glycoprotein, ceruloplasmine and C-reactive protein represent more sensitive inflammation markers as compared to erythrocyte sedimentation rate. The identification of acute phase reactants is important in the evaluation of dosed balneotherapy efficiency in the treatment of ankylosing spondylitis.
mesh_terms: D000328:Adult; D001452:Balneology; D002097:C-Reactive Protein / Q000032:analysis; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D009961:Orosomucoid / Q000032:analysis; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000628:therapy*
chemical_list: D009961:Orosomucoid; D002097:C-Reactive Protein; D002570:Ceruloplasmin