title: Differences in lopinavir plasma concentrations comparing Kaletra film coated tablets and soft gelatine capsules that result in various lipid abnormalities.
abstract: Changes in lipids and lopinavir plasma concentrations were examined in 40 HIV-patients exposed to lopinavir/ritonavir 400/100 mg BID, formulated as tablets and as capsules. Triglycerides and total/HDL-cholesterol ratio were significantly lower with tablets than with capsules. Lopinavir concentrations were higher with tablets than with capsules.
authors: Department of Pharmacy, Hospital Carlos III, Madrid, Spain.
authors: Judit
authors: J
authors: Morello
authors: Vincent
authors: V
authors: Soriano
authors: Francisco
authors: F
authors: Blanco
authors: Antonio J
authors: AJ
authors: Rubio
authors: Inmaculada
authors: I
authors: Jiménez-Nácher
authors: Sonia
authors: S
authors: Rodríguez-Nóvoa
mesh_terms: D000328:Adult; D002214:Capsules; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D004338:Drug Combinations; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D061466:Lopinavir; D008297:Male; D008875:Middle Aged; D011744:Pyrimidinones / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D012189:Retrospective Studies; D019438:Ritonavir / Q000008:administration & dosage / Q000009:adverse effects; D013607:Tablets; D014280:Triglycerides / Q000097:blood
chemical_list: D002214:Capsules; D008076:Cholesterol, HDL; D004338:Drug Combinations; D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D013607:Tablets; D014280:Triglycerides; D061466:Lopinavir; D002784:Cholesterol; D019438:Ritonavir