A DNA-binding Gd chelate for the detection of cell death by MRI.
GadoTO, a MR contrast agent for the detection of cell death, consists of a nucleic acid-binding fluorophore attached to a gadolinium chelate.
Garanger
Elisabeth
E
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hilderbrand
Scott A
SA
Blois
Joseph T
JT
Sosnovik
David E
DE
Weissleder
Ralph
R
Josephson
Lee
L
D016923:Cell Death; D002614:Chelating Agents / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D002614:Chelating Agents; D003287:Contrast Media; C544434:GadoTO4; D009942:Organometallic Compounds; D004247:DNA; D005682:Gadolinium