title: Serum CXCL16 concentrations correlate with the extent of skin sclerosis in patients with systemic sclerosis.
abstract: OBJECTIVE
  To determine serum concentrations of soluble CXCL16 and its clinical associations in patients with systemic sclerosis (SSc).
  
  
  METHODS
  Serum CXCL16 levels from 89 patients with SSc were examined by ELISA. In a retrospective longitudinal study, 68 sera from 28 patients with SSc were analyzed (followup 1.3 to 7.3 yrs).
  
  
  RESULTS
  Serum CXCL16 levels were elevated in patients with SSc compared with healthy controls (n = 42). Patients with diffuse cutaneous SSc (n = 52) had higher levels of CXCL16 than those with limited cutaneous SSc (n = 37). Serum CXCL16 levels correlated positively with the extent of skin sclerosis. In the longitudinal study, CXCL16 levels generally decreased on a parallel with the improvement in skin sclerosis.
  
  
  CONCLUSIONS
  CXCL16 levels were increased in patients with SSc, and correlated with the extent of skin sclerosis, suggesting that CXCL16 may have a role in the development of skin fibrosis in SSc. Blockade of CXCL16 interaction might be a potential therapeutic target in patients with SSc.
authors: Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Koichi
authors: K
authors: Yanaba
authors: Eiji
authors: E
authors: Muroi
authors: Ayumi
authors: A
authors: Yoshizaki
authors: Toshihide
authors: T
authors: Hara
authors: Fumihide
authors: F
authors: Ogawa
authors: Kazuhiro
authors: K
authors: Shimizu
authors: Mariko
authors: M
authors: Yozaki
authors: Minoru
authors: M
authors: Hasegawa
authors: Manabu
authors: M
authors: Fujimoto
authors: Kazuhiko
authors: K
authors: Takehara
authors: Shinichi
authors: S
authors: Sato
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC / Q000097:blood*; D002648:Child; D003882:Dermatomyositis / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D008297:Male; D008875:Middle Aged; D051116:Receptors, Scavenger / Q000097:blood*; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000097:blood* / Q000209:etiology / Q000473:pathology*; D012598:Sclerosis; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology*; D055815:Young Adult
chemical_list: C423727:CXCL16 protein, human; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC; D051116:Receptors, Scavenger