Basic mechanisms of urgency: roles and benefits of pharmacotherapy.
BACKGROUND
Since urgency is key to the overactive bladder syndrome, we have reviewed the mechanisms underlying how bladder filling and urgency are sensed, what causes urgency and how this relates to medical therapy.


METHODS
Review of published literature.


RESULTS
As urgency can only be assessed in cognitively intact humans, mechanistic studies of urgency often rely on proxy or surrogate parameters, such as detrusor overactivity, but these may not necessarily be reliable. There is an increasing evidence base to suggest that the sensation of ‘urgency’ differs from the normal physiological urge to void upon bladder filling. While the relative roles of alterations in afferent processes, central nervous processing, efferent mechanisms and in intrinsic bladder smooth muscle function remain unclear, and not necessarily mutually exclusive, several lines of evidence support an important role for the latter.


CONCLUSIONS
A better understanding of urgency and its causes may help to develop more effective treatments for voiding dysfunction.
Michel
Martin Christian
MC
Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. m.c.michel@amc.nl
Chapple
Christopher R
CR
D006801:Humans; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D001743:Urinary Bladder / Q000294:innervation / Q000502:physiology; D053201:Urinary Bladder, Overactive / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D014555:Urination Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
D018727:Muscarinic Antagonists