title: Effects of Lactobacillus fermented soymilk and soy yogurt on hepatic lipid accumulation in rats fed a cholesterol-free diet.
abstract: We examined the effects of lactic acid fermented soymilk, in which part of the soymilk was replaced with okara (soy yogurt), on plasma and hepatic lipid profiles in rats fed a cholesterol-free diet. Additionally, we investigated the effects of soy yogurt on hepatic gene expression in rats using DNA microarray analysis. Male Sprague-Dawley rats aged 5 weeks (n=5/group) were fed a control diet (AIN-93) or a test diet in which 20% of the diet was replaced by soy yogurt for 7 weeks. Soy yogurt consumption did not affect body weight or adipose tissue weight as compared with control diet. In the soy yogurt group, the liver weight and hepatic triglyceride content were significantly lower than the control group, and the level of plasma cholesterol was also lower. Furthermore, DNA microarray analysis indicated that soy yogurt ingestion down-regulated the expression of the SREBP-1 gene and enzymes related to lipogenesis in the rat liver, while expression of beta-oxidation-related genes was up-regulated. These results suggest that soy yogurt is beneficial in preventing hepatic lipid accumulation in rats.
authors: Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan. senjuoka@mukogawa-u.ac.jp
authors: Ryoko
authors: R
authors: Kitawaki
authors: Yuko
authors: Y
authors: Nishimura
authors: Naohiro
authors: N
authors: Takagi
authors: Mitsuhiro
authors: M
authors: Iwasaki
authors: Kimiko
authors: K
authors: Tsuzuki
authors: Mitsuru
authors: M
authors: Fukuda
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002791:Cholesterol, Dietary; D004032:Diet; D004435:Eating / Q000187:drug effects; D005243:Feces; D005285:Fermentation; D005786:Gene Expression Regulation / Q000187:drug effects; D019344:Lactic Acid / Q000378:metabolism; D007778:Lactobacillus / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D041942:Soy Milk / Q000378:metabolism / Q000494:pharmacology*; D015014:Yogurt / Q000382:microbiology*
chemical_list: D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D008055:Lipids; D019344:Lactic Acid