The clearance of unidentified uremic solutes (with molecular weight under 5 kDa) plays an important role in hemodialyzer selection.
BACKGROUND
The purpose of this study was to evaluate two commercial hemodialyzers (F100 and P21) through the clearance of identified and unidentified uremic solutes.


METHODS
We investigated plasma samples from healthy and uremic subjects.


RESULTS
We found three unidentified uremic solutes (P1, P2, and P3) after HPLC analysis of plasma samples. Then, we determined the clearance of four identified and the three unidentified uremic solutes in patients with F100 and P21. There was no significance between F100 and P21 in clearance of four identified uremic solutes. By contrast, the clearance of P1 and P2 with F100 was superior with the P21 (P < 0.05).


CONCLUSIONS
Our data suggest that selection of a hemodialyzer based on the clearance of identified uremic solutes might not be sufficient. Application of external techniques to determine additional external factors (i.e., clearance of unidentified uremic solutes) can facilitate a better decision in the selection of the ideal hemodialyzer.
Chen
Tung-Sheng
TS
Department of Biomedical Engineering, Chung Yuan Christian University, 200, Chung Pei Rd., Chung Li 32023, Taiwan, ROC. tschen0196@yahoo.com.tw
Liou
Shaw-Yih
SY
Chang
Yen-Lin
YL
D000328:Adult; D000368:Aged; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005260:Female; D015312:Hemodialysis Solutions; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D010710:Phosphates / Q000097:blood; D006435:Renal Dialysis / Q000295:instrumentation*; D051437:Renal Insufficiency / Q000097:blood* / Q000150:complications / Q000628:therapy*; D014511:Uremia / Q000097:blood* / Q000209:etiology; D014527:Uric Acid / Q000097:blood
D015312:Hemodialysis Solutions; D010710:Phosphates; D014527:Uric Acid; D003404:Creatinine