Gene expression of adrenomedullin in canine normal tissues and diseased hearts.
The purposes of this study were to determine the tissue distribution of canine adrenomedullin (AM) and to determine whether increased canine AM mRNA expression is associated with congestive heart failure (CHF) due to mitral regurgitation (MR). Canine AM mRNA expression was detectable in various normal tissues, including cardiovascular tissues. In addition, the AM mRNA expression in the left atrium of dogs with MR was significantly higher than that in normal subjects. In conclusion, AM is a potential neurohumoral factor in dogs with CHF due to MR.
Kanno
Nobuyuki
N
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Japan.
Asano
Kazushi
K
Teshima
Kenji
K
Kutara
Kenji
K
Seki
Mamiko
M
Edamura
Kazuya
K
Kano
Rui
R
Hasegawa
Atsuhiko
A
Tanaka
Shigeo
S
D053607:Adrenomedullin / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics* / Q000378:metabolism; D004285:Dogs; D015870:Gene Expression; D006333:Heart Failure / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D009206:Myocardium / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D018709:Statistics, Nonparametric
D012333:RNA, Messenger; D020097:Natriuretic Peptide, Brain; D053607:Adrenomedullin; D009320:Atrial Natriuretic Factor