title: An updated review of tyrosinase inhibitors.
abstract: Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.
authors: Department of Biological Science and Technology, National University of Tainan, 33 sec. 2 Shu-Lin St., Tainan, Taiwan.
authors: Te-Sheng
authors: TS
authors: Chang
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry / Q000378:metabolism; D001565:Benzoates / Q000737:chemistry / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D008543:Melanins / Q000378:metabolism; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D059808:Polyphenols / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D013256:Steroids / Q000737:chemistry / Q000378:metabolism
chemical_list: D001547:Benzaldehydes; D001565:Benzoates; D001688:Biological Products; D004791:Enzyme Inhibitors; D008543:Melanins; D059808:Polyphenols; D013256:Steroids; D014442:Monophenol Monooxygenase