Elliptical magnetic resonance spectroscopic imaging with GRAPPA for imaging brain tumors at 3 T.
Magnetic Resonance Spectroscopic Imaging (MRSI) is a technique for imaging spatial variation of metabolites and has been very useful in characterizing biochemical changes associated with disease as well as response to therapy in malignant pathologies. This work presents a self-calibrated undersampling to accelerate 3D elliptical MRSI and an extrapolation-reconstruction algorithm based on the GRAPPA method. The accelerated MRSI technique was tested in three volunteers and five brain tumor patients. Acceleration allowed larger spatial coverage and consequently, less lipid contamination in spectra, compared to fully sampled acquisition within the same scantime. Metabolite concentrations measured from the accelerated acquisitions were in good agreement with measurements obtained from fully sampled MRSI scans.
Banerjee
Suchandrima
S
Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA. suchandrima.banerjee@ge.com
Ozturk-Isik
Esin
E
Nelson
Sarah J
SJ
Majumdar
Sharmila
S
D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D002138:Calibration; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008055:Lipids / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods; D012815:Signal Processing, Computer-Assisted; D012984:Software; D013997:Time Factors
D008055:Lipids