title: Natural history of benign prostatic enlargement: long-term longitudinal population-based study of prostate volume doubling times.
abstract: OBJECTIVE
  To measure prostate volume doubling times (PVDTs) for a large sample of community men followed serially by transrectal ultrasonography (TRUS), and to determine whether specific characteristics are associated with a rapid PVDT.
  
  
  METHODS
  A subsample of 446 subjects from a larger cohort of American white men aged 40-79 years were evaluated biennially for a median (range) follow-up of 10 (3-14) years. Mixed-effects regression models were used to estimate prostate growth rates and PVDT for subjects with three or more or with five or more serial biennial TRUS PV measurements.
  
  
  RESULTS
  The median (25-75th percentile) PVDT was 32.6 (24.6-44.0) years. The average annual increase in PV was 2.2%. The PVDT distribution was constant in men of all age groups studied (r < 0.001, P = 0.99). The factor most strongly associated with PVDT was baseline transition zone volume (r = -0.55, P < 0.001). Baseline total prostate-specific antigen (PSA) level, free PSA and total PV were also significantly inversely associated with PVDT (r = -0.30, -0.44 and -0.32, respectively, all P < 0.001). Age, baseline anthropomorphic measurements, hormone levels and specific lifestyle characteristics were not significantly correlated with PVDT.
  
  
  CONCLUSIONS
  These data indicate that PVDT might be a useful future measure of benign prostatic growth. They provide a basis to forecast PV at 10, 20, or 30 years later, after one baseline TRUS measurement of prostate volume, and can be presented in a simple nomogram.
authors: Department of Urology, Mayo Clinic, Rochester, MN 55905, USA.
authors: Michael M
authors: MM
authors: Lieber
authors: Thomas
authors: T
authors: Rhodes
authors: Debra J
authors: DJ
authors: Jacobson
authors: Michaela E
authors: ME
authors: McGree
authors: Cynthia J
authors: CJ
authors: Girman
authors: Steven J
authors: SJ
authors: Jacobsen
authors: Jennifer L
authors: JL
authors: St Sauver
mesh_terms: D000328:Adult; D000368:Aged; D004812:Epidemiologic Methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D049451:Nomograms; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000473:pathology*; D013997:Time Factors
chemical_list: D017430:Prostate-Specific Antigen