title: [A clinical study of chromosome translocations in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in Chinese patients].
abstract: OBJECTIVE
  To investigate the genetic aberrations in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphomas from different sites of the body in Chinese patients.
  
  
  METHODS
  Two hundred and seventeen paraffin-embedded MALT lymphoma specimens from 11 major sites were studied with interphase fluorescence in situ hybridization (FISH) to detect t (11; 18) (q21; q21)/API2-MALT1, t (1; 14) (p22; q32)/IGH-BCL10, (14; 18) (q32; q21)/IGH-MALT1 and BCL6 gene involved chromosome translocations.
  
  
  RESULTS
  These translocations were mutually exclusive and detected in 21% (46/217) of the cases, including t (11; 18) (q21; q21) API2-MALT1 13% (29/217), t (1; 14) (p22; q32) IGH-BCL10 in 1% (3/217), t (14; 18) (q32; q21) IGH-MALT1 1% (2/217), BCL6 involved translocation in 2% (4/217) and IGH-unknown translocation partner in 4% (8/217). t (11; 18) (q21; q21) API2-MALT1 was found with the highest frequency in MALT lymphoma from lungs (47%, 8/17) and small intestine (29%, 4/14), followed by salivary gland (17%, 1/6), stomach (14%, 12/84) and ocular adnexae (6%, 4/68). t (1; 14) (p22; q32) was only detected in lungs (12%, 2/17) and stomach (1%, 1/84). t (14; 18) (q32; q21) was mainly detected in lungs (6%, 1/17) and ocular adnexae (2%, 1/68). BCL6 gene involved translocation was detected in salivary gland (17%, 1/6) and stomach (4%, 3/84).
  
  
  CONCLUSIONS
  It is demonstrated that the four translocations occur with markedly variable frequencies in MALT lymphoma of different sites in Chinese patients. The distributions of these chromosome translocations in Chinese patients are slightly different from those reported in western patients.
authors: Department of Pathology, Health Science Center, Peking University, Beijing 100191, China.
authors: Ge-Hong
authors: GH
authors: Dong
authors: Gui-Qiu
authors: GQ
authors: Wang
authors: Li-Ping
authors: LP
authors: Gong
authors: Jin-Fen
authors: JF
authors: Wang
authors: Xiang-Lan
authors: XL
authors: Mo
authors: Hong-Gang
authors: HG
authors: Liu
authors: Li-Na
authors: LN
authors: Dong
authors: Ying-Qiong
authors: YQ
authors: Zhou
authors: Xue-Mei
authors: XM
authors: Zhang
authors: Zhen-Bo
authors: ZB
authors: Feng
authors: Zi-Fen
authors: ZF
authors: Gao
authors: Hong-Tao
authors: HT
authors: Ye
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002648:Child; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D055815:Young Adult