Broad-spectrum antimicrobial epiphytic and endophytic fungi from marine organisms: isolation, bioassay and taxonomy.
In the search for new marine derived antibiotics, 43 epi- and endophytic fungal strains were isolated from the surface or the inner tissue of different marine plants and invertebrates. Through preliminary and secondary screening, 10 of them were found to be able to produce broad-spectrum antimicrobial metabolites. By morphological and molecular biological methods, three active strains were characterized to be Penicillium glabrum, Fusarium oxysporum, and Alternaria alternata.
Zhang
Yi
Y
Department of Biotechnology, School of Environmental and Chemical Engineering, Dalian Jiaotong University, Dalian 116028, P.R. China. zhangyi@djtu.edu.cn
Mu
Jun
J
Feng
Yan
Y
Kang
Yue
Y
Zhang
Jia
J
Gu
Peng-Juan
PJ
Wang
Yu
Y
Ma
Li-Fang
LF
Zhu
Yan-Hua
YH
D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D056890:Eukaryota / Q000382:microbiology*; D005658:Fungi / Q000145:classification / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D007448:Invertebrates / Q000382:microbiology*; D008386:Marine Biology; D008969:Molecular Sequence Data; D010802:Phylogeny; D013559:Symbiosis / Q000502:physiology
D000890:Anti-Infective Agents; D021903:DNA, Ribosomal Spacer