Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known beta-carboline alkaloids and one quassinoid have been isolated from MeOH extract of the wood of Picrasma quassioides Benn. These compounds were screened for their inhibitory activities against tobacco mosaic virus (TMV). The activity of each compound against TMV infection and replication was tested using a half-leaf assay method, a leaf-disk method, and Western blotting analyses. All of the beta-carboline alkaloids showed moderate anti-TMV activities and exhibited synergistic effects when combined with the quassinoid nigakilactone B (11). To our knowledge, this is the first report on anti-TMV activity of beta-carbolines and their synergistic effects against TMV when combined with a quassinoid.
Chen
Jia
J
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Yan
Xiao-Hui
XH
Dong
Jia-Hong
JH
Sang
Peng
P
Fang
Xin
X
Di
Ying-Tong
YT
Zhang
Zhong-Kai
ZK
Hao
Xiao-Jiang
XJ
D000470:Alkaloids / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D032270:Picrasma / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D014027:Tobacco Mosaic Virus / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D000470:Alkaloids; D000998:Antiviral Agents; D002243:Carbolines; D010936:Plant Extracts