title: Cytotoxic 16-beta-[(D-xylopyranosyl)oxy]oxohexadecanyl triterpene glycosides from a Malagasy plant, Physena sessiliflora.
abstract: Brine shrimp lethality assay-guided separation of the MeOH extract of leaves of Physena sessiliflora, which is endemic to Madagascar, afforded eight triterpene glycosides, Physenoside S1-4 and 16-beta-[(d-xylopyranosyl)oxy]oxohexadecanyl homologues, Physenoside S5-8. Structural elucidation of these compounds was based on both spectroscopic analyses and chemical properties. Physenoside S7 and S8 have significant cytotoxic activities in the brine shrimp lethality assay.
authors: Department of Medicinal Chemistry, Graduate School of Biomedical Sciences, Hiroshima University, 734-8551 Hiroshima, Japan. Electronic address: D066862@hiroshima-u.ac.jp.
authors: Masaki
authors: M
authors: Inoue
authors: Department of Medicinal Chemistry, Graduate School of Biomedical Sciences, Hiroshima University, 734-8551 Hiroshima, Japan.
authors: Kazuhiro
authors: K
authors: Ohtani
authors: Department of Medicinal Chemistry, Graduate School of Biomedical Sciences, Hiroshima University, 734-8551 Hiroshima, Japan.
authors: Ryoji
authors: R
authors: Kasai
authors: Department of Medicinal Chemistry, Graduate School of Biomedical Sciences, Hiroshima University, 734-8551 Hiroshima, Japan.
authors: Mayu
authors: M
authors: Okukubo
authors: Laboratoire de Chimie Organigue, Produits Naturels, Universite' d'Antananarivo, Madagascar.
authors: Marta
authors: M
authors: Andriantsiferana
authors: Department of Medicinal Chemistry, Graduate School of Biomedical Sciences, Hiroshima University, 734-8551 Hiroshima, Japan.
authors: Kazuo
authors: K
authors: Yamasaki
authors: Department of Medicinal Chemistry, Graduate School of Biomedical Sciences, Hiroshima University, 734-8551 Hiroshima, Japan.
authors: Tohru
authors: T
authors: Koike
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D031483:Capparaceae / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D003603:Cytotoxins; D006027:Glycosides; D014315:Triterpenes