title: Clinical and experimental effectiveness of Astragali compound in the treatment of chronic viral hepatitis B.
abstract: Chinese herbs are widely used in the treatment of chronic viral hepatitis B. The effectiveness of 2 months' treatment with Astragali compound (AC), containing Radix Astragali and adjuvant components, was studied for the treatment of chronic viral hepatitis in 116 patients; 92 patients were given other drugs in regular clinical use for viral hepatitis (controls). The clinical efficacy of AC was significantly better in AC-treated patients than in controls. Negative seroconversions of hepatitis B virus (HBV) antigen e and HBV DNA were also significantly higher in AC-treated patients than in controls. Of eight duck viral hepatitis B models infected with duck hepatitis B virus (DHBV) and treated with AC, three showed negative seroconversion of DHBV DNA and serum DHBV DNA levels significantly decreased after AC administration compared with the controls; DHBV DNA was negative in biopsied liver tissue by in situ hybridization and immunohistochemistry in two ducks treated with AC. Pathological changes were milder in AC-treated ducks than in controls. These results indicate that AC may promote recovery from viral hepatitis and inhibit HBV replication.
authors: Department of Infectious Disease, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors: L L
authors: LL
authors: Tang
authors: J F
authors: JF
authors: Sheng
authors: C H
authors: CH
authors: Xu
authors: K Z
authors: KZ
authors: Liu
mesh_terms: D000818:Animals; D004279:DNA, Viral / Q000097:blood; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D015611:Hepatitis B Virus, Duck / Q000187:drug effects; D019694:Hepatitis B, Chronic / Q000097:blood / Q000188:drug therapy*; D006524:Hepatitis, Viral, Animal / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D016896:Treatment Outcome
chemical_list: C543477:Astragali compound; D004279:DNA, Viral; D004365:Drugs, Chinese Herbal