title: Two variants of staphylococcal cassette chromosome mec type IVA in community-associated meticillin-resistant Staphylococcus aureus strains in South Korea.
abstract: Meticillin-resistant Staphylococcus aureus (MRSA) strains harbouring staphylococcal cassette chromosome mec (SCCmec) type IVA are known to be more prevalent in South Korea than in other countries. Variations in the SCCmec IVA structure have been identified, including in sequence type (ST) 1 and ST72 strains. This study compared and investigated the genetic characteristics of two subtypes common in South Korea. Type IVA SCCmec of ST1 strains was characterized by type IV features with the linearized pUB110 at the junkyard (J) 3 region. However, that of ST72 strains carried a variant class B mec complex, ccrA2, with an identity of approximately 96 % and the linearized pUB110 at the J3 region. In SCCmec of ST72 strains, the organization of the class B variant and the J3 region may be more similar to that of type IA than to other types, but the ccr type and other J regions seemed to be derived from type IV. These genetic characteristics showed that type IVA appears to result from the dynamic genetic exchange and recombination of SCC DNA.
authors: Catholic Research Institutes of Medical Science, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Chulmin
authors: C
authors: Park
authors: Catholic Research Institutes of Medical Science, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Hyun-Ho
authors: HH
authors: Shin
authors: Catholic Research Institutes of Medical Science, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Eun-Young
authors: EY
authors: Kwon
authors: Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Su-Mi
authors: SM
authors: Choi
authors: Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Si-Hyun
authors: SH
authors: Kim
authors: Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Sun Hee
authors: SH
authors: Park
authors: Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Jung-Hyun
authors: JH
authors: Choi
authors: Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Jin-Hong
authors: JH
authors: Yoo
authors: Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Dong-Gun
authors: DG
authors: Lee
authors: Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
authors: Wan Shik
authors: WS
authors: Shin
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000235:genetics; D017714:Community-Acquired Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D017931:DNA Primers / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D007723:Korea / Q000453:epidemiology; D016106:Methicillin Resistance / Q000235:genetics*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D046915:Penicillin-Binding Proteins; D010802:Phylogeny; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D017931:DNA Primers; D004269:DNA, Bacterial; D046915:Penicillin-Binding Proteins; C487789:mecA protein, Staphylococcus aureus