Investigation of multifocal choroiditis with panuveitis by three-dimensional high-penetration optical coherence tomography.
A single case of multifocal choroiditis with panuveitis (MFCPU) was investigated by a three-dimensional (3-D) high-penetration optical coherence tomography. The HP-OCT is based on a swept-source OCT technology, uses a probe beam with a center wavelength of 1060 nm, and possesses a depth resolution of 10.4 micromin tissue. Two eyes of an MFCPU patient were involved in this study. The eyes were also examined by color fundus photograph, fluorescein angiography (FA), and indocyanine green angiography (ICGA). Findings in these four modalities are comparatively discussed. The OCT scans revealed the following characteristic properties of the lesion sites. Thinning of the retina, destructuring of the retinal layers, and disappearance of the junction of the inner and outer segments of the photoreceptor (IS/OS). Due to the high penetration of this OCT system, the following characteristic properties of the lesions were also observed: localized thinning of the choroid, occlusion of the choroidal vessels, and localized hyper-reflectivity that may represent hyper-pigmentation of the choroid.
Yasuno
Yoshiaki
Y
Computational Optics Group, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, Japan. yasuno@optlab2.bk.tsukuba.ac.jp
Okamoto
Fumiki
F
Kawana
Keisuke
K
Yatagai
Toyohiko
T
Oshika
Tetsuro
T
D000328:Adult; D000792:Angiography; D002833:Choroiditis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D019793:Fluorescein / Q000378:metabolism; D006801:Humans; D021621:Imaging, Three-Dimensional; D007208:Indocyanine Green / Q000378:metabolism; D041623:Tomography, Optical Coherence
D007208:Indocyanine Green; D019793:Fluorescein