[Recent advances in cell and gene therapies for Parkinson's disease].
Parkinson's disease (PD) is a progressive neurodegenerative disorder clinically characterized by movement abnormalities. Selective loss of nigrostriatal dopaminergic neurons is the pathological hallmark of PD. Currently most prevailing treatment is oral administration of dopamine-related compounds, however, the prolonged drug treatment causes adverse side effects such as dyskinesia. ector-mediated in vivo gene therapy is now going to provide novel therapeutic options. In this review, we will focus on history and recent clinical trials in cell and gene therapies and discuss novel approaches for the treatment of inherited and sporadic forms of PD.
Yasuda
Toru
T
Research Institute for Diseases of Old Age, Juntendo University School of Medicine.
Mochizuki
Hideki
H
D017690:Cell Transplantation / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D010300:Parkinson Disease / Q000628:therapy*