title: Regional techniques and outcome: what is the evidence?
abstract: OBJECTIVE
  Despite some controversy regarding the strength of the available data, the use of regional anesthesia and analgesia does provide improvement in patient outcomes. Although the majority of available data have examined the effect of epidural anesthesia and analgesia on patient outcomes, an increasing number of studies recently have investigated the effect of peripheral regional techniques on patient outcomes.
  
  
  RESULTS
  Data generally indicate that the perioperative use of regional anesthesia and analgesia may be associated with improvement in both major (e.g. mortality, major morbidity) outcomes and rehabilitation. The majority of evidence favors an ability of epidural analgesia to reduce postoperative cardiovascular and pulmonary complications and there is also consistent evidence that epidural analgesia with local anesthetics is associated with faster resolution of postoperative ileus after major abdominal surgery. Overall, regional analgesic techniques provide statistically superior analgesia compared with systemic opioids.
  
  
  CONCLUSIONS
  Perioperative use of regional analgesic techniques may provide improvement in conventional outcomes, although the benefit appears to be limited to high-risk patients and those undergoing high-risk procedures. The benefits conferred by perioperative regional anesthetic techniques need to be weighed against any potential risks and this should be assessed on an individual basis.
authors: Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
authors: Marie N
authors: MN
authors: Hanna
authors: Jamie D
authors: JD
authors: Murphy
authors: Kanupriya
authors: K
authors: Kumar
authors: Christopher L
authors: CL
authors: Wu
mesh_terms: D000698:Analgesia / Q000379:methods*; D000765:Anesthesia, Conduction / Q000379:methods*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D005767:Gastrointestinal Diseases / Q000517:prevention & control; D006801:Humans; D008171:Lung Diseases / Q000517:prevention & control; D009422:Nervous System Diseases / Q000517:prevention & control; D019990:Perioperative Care / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000592:standards