title: High incidence of chronic lymphocytic leukemia (CLL) diagnosed by immunophenotyping: a population-based Canadian cohort.
abstract: Incidence and outcomes of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are not well established at the population level, especially since the widespread use of immunophenotyping. We studied the epidemiology of CLL in Manitoba (Canada) by combining data from a centralized flow cytometry facility and the provincial cancer registry for the period 1998-2003. Of 616 cases identified, 27% of patients identified by flow cytometry were not on the cancer registry. The age-adjusted incidence of 7.99/100,000 is substantially higher than the reported incidence in registry reports. We also noted differences in relative survival based on age and gender.
authors: Section of Haematology/Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. mseftel@cancercare.mb.ca
authors: M D
authors: MD
authors: Seftel
authors: A A
authors: AA
authors: Demers
authors: V
authors: V
authors: Banerji
authors: S B
authors: SB
authors: Gibson
authors: C
authors: C
authors: Morales
authors: G
authors: G
authors: Musto
authors: M W
authors: MW
authors: Pitz
authors: J B
authors: JB
authors: Johnston
mesh_terms: D015331:Cohort Studies; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D015994:Incidence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D008350:Manitoba / Q000453:epidemiology; D012042:Registries; D016019:Survival Analysis