[Expression, distribution and biological function of leptin receptor in the testis].
Leptin, a 167-amino acid peptidic hormone encoded by the obese gene, is known to be involved in the regulation of body fat, energy expenditure, immune function, angiogenesis, inflammatory reaction, the onset of puberty, and the regulation of reproductive function. The roles of leptin vary with different expression and distribution patterns of its receptor Ob-R. This article analyzes the biological effects of leptin and its receptor on the testis by reviewing the expression and distribution of Ob-R in different cells during different developmental stages or in different physiological and pathological states in the testis of men, mice or rats.
Gao
Long
L
Department of Urology, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China.
Chen
Bin
B
D000818:Animals; D006801:Humans; D008297:Male; D051379:Mice; D051381:Rats; D054411:Receptors, Leptin / Q000378:metabolism*; D013737:Testis / Q000378:metabolism*
D054411:Receptors, Leptin