Interaction of drug based binuclear mixed-ligand complexes with DNA.
Here in we tried to increase an antibacterial activity of ciprofloxacin drug due to formation of mixed-ligand complexes. Synthesized compounds were found to be more potent compare to drugs, ligands and metal salt against selective gram((+ve)) and gram((-ve)) organisms. Interaction of the complexes with nucleic acid (DNA) were investigated using spectroscopic technique, viscosity measurement and gel electrophoresis and it was found that the complexes bind to DNA via intercalative mode.
Patel
Mohan N
MN
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120 Gujarat, India. jeenen@gmail.com
Chhasatia
Mehulsinh R
MR
Gandhi
Deepen S
DS
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001665:Binding Sites; D002939:Ciprofloxacin / Q000737:chemistry* / Q000494:pharmacology*; D003035:Cobalt / Q000737:chemistry* / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013696:Temperature; D014783:Viscosity
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D008024:Ligands; D003035:Cobalt; D002939:Ciprofloxacin