title: Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions.
abstract: Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tablets from solid dispersions. The physical state and drug:carrier interactions were analyzed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration.
authors: Departamento Farmacia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina. mlamas@fbioyf.unr.edu.ar
authors: Maria Celina
authors: MC
authors: Lamas
authors: Darío
authors: D
authors: Leonardi
authors: Osvaldo A
authors: OA
authors: Lambri
authors: Georgina
authors: G
authors: Bassani
authors: María G
authors: MG
authors: Barrera
authors: Raúl E
authors: RE
authors: Bolmaro
authors: Claudio J
authors: CJ
authors: Salomon
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D004008:Diclofenac / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D013607:Tablets; D004008:Diclofenac; D011205:Povidone