[The value of hepatic ischemic preconditioning in hepatectomy with a prospective randomized controlled study].
OBJECTIVE
To evaluate the value of ischemic preconditioning in clinical hepatectomy.


METHODS
A total of 48 unselected patients undergoing liver resection were analyzed by randomized controlled trial from December 2004 to June 2006. Forty-eight unselected patients were randomized into two groups: IP group (5 minutes of ischemia followed by 5 minutes of reperfusion) and control group (received Pringle's maneuver no and no IP was given). Postoperative days 1, 3 and 7, the liver function were checked. Perioperative mortality, morbidity and hospitalized days were compared.


RESULTS
In IP group, ischemic times were 5 - 80 min, mean 31 min, hospitalized days were 13 - 50 days, mean 20 days. In control group, ischemic times were 10 - 60 min, mean 27 min, hospitalized days were 10 - 33 days, mean 17 days. Forty-seven patients were satisfactory with postoperative recovery, except one patient died of chronic liver dysfunction after 3 months postoperatively. Postoperative days 1, 3 and 7, the ALT, AST, TBIL, ALB levels in two groups were not statistically significant (P > 0.05).


CONCLUSIONS
The clinical use of IP through 5 minutes of warm ischemia in this technique of hepatectomy does not protect the liver from hepatic injury induced by the IRI.
Hou
Hui
H
Department of Hepatobiliary Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Geng
Xiao-ping
XP
Zhu
Li-xin
LX
Ye
Bo-gen
BG
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D019194:Ischemic Preconditioning; D008099:Liver / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015427:Reperfusion Injury / Q000517:prevention & control; D055815:Young Adult