title: Radiotherapy is not associated with an increased rate of Second Primary Tumours in Oral Squamous Carcinoma: a study of 370 patients.
abstract: Oral Squamous Cell Carcinoma (OSCC) remains a public health scourge. Radiotherapy (RT) is a major treatment modality and has been implicated in possible formation of Second Primary Tumours (SPT). In a single centre retrospective study of 370 patients with OSCCs (1967-2004) associations between RT, diagnosis of SPTs, median SPT diagnostic time lag, Disease Free Survival (DFS) and overall survival (OS) were analysed. Sixty-eight (18.4%) patients developed metachronous SPTs. Two hundred and twenty patients (59.3%) underwent some form of RT whilst 151 (40.7%) patients were not exposed to RT. No significant increased incidence of SPTs was demonstrated in the RT group. No significant difference in SPT diagnostic time lag was noted amongst the groups. This study suggests that RT is neither a risk for SPT induction nor increases the relative diagnostic time delay of upper aero-digestive tract SPTs.
authors: Department of Plastic Surgery St Vincent's Hospital Melbourne, Prince of Wales Post graduate clinical School, UNSW, Sydney, High St Randwick 2031, Australia. rostam74@yahoo.com.au
authors: Ross Darius
authors: RD
authors: Farhadieh
authors: Petr
authors: P
authors: Otahal
authors: Charles Geoffrey Gordon
authors: CG
authors: Rees
authors: Arash
authors: A
authors: Salardini
authors: Pamela
authors: P
authors: Russell
authors: Robert
authors: R
authors: Smee
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D009517:New South Wales / Q000453:epidemiology; D011379:Prognosis; D018787:Radiation Oncology / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors