Phosphate-assisted peptide ligation.
A novel ligation method for the synthesis of phosphopeptides and peptides is described, which utilises the inherent reactivity of a peptide bearing an N-terminal phosphoserine or phosphothreonine residue to facilitate amide bond formation with a range of C-terminal peptide thioesters.
Thomas
Gemma L
GL
School of Chemistry, The University of Sydney, Sydney, Australia.
Payne
Richard J
RJ
D002851:Chromatography, High Pressure Liquid; D007700:Kinetics; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D010455:Peptides; D010710:Phosphates