title: A novel association between polycystic ovary syndrome and Helicobacter pylori.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies. Chronic infections may increase the risk of infertility. Helicobacter pylori infection has been found to be associated with infertility, and PCOS is also one of the most common causes of infertility. To the best of our knowledge, the possible association between H. pylori seropositivity and PCOS has never been investigated.
  
  
  METHODS
  We performed a prospective study between a group of PCOS subjects and an age-matched group of controls. This prospective study included 35 women (mean age, 25 +/- 5 years) with PCOS, selected by using revised diagnostic criteria of European Society for Human Reproduction and Embryology and the American Society for Reproductive Medicine 2003, who were compared with their age-matched control group (50 women; mean age, 26 +/- 5 years). The 1-step H. pylori test device was used to detect IgG-type antibodies to H. pylori in serum, to aid in the diagnosis of H. pylori infection.
  
  
  RESULTS
  H. pylori seropositivity was found to be significantly higher in the PCOS group (PCOS 40%; control 22%; P = 0.007).
  
  
  CONCLUSIONS
  We suggest a possible association between H. pylori seropositivity and PCOS. It is early to state that H. pylori is a new etiological factor for PCOS or the association of PCOS and H. pylori infection is coincidental with these data. Further studies evaluating more subjects are required.
authors: Division of Internal Medicine, Balmumcu Military Medical Center, Istanbul, Turkey. dr_yavas@yahoo.com
authors: Irfan
authors: I
authors: Yavasoglu
authors: Mert
authors: M
authors: Kucuk
authors: Burak
authors: B
authors: Cildag
authors: Erol
authors: E
authors: Arslan
authors: Mehmet
authors: M
authors: Gok
authors: Samet
authors: S
authors: Kafkas
mesh_terms: D000328:Adult; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D011446:Prospective Studies; D055815:Young Adult