Microbubbles as drug delivery systems in cerebrovascular diseases.
The field of neurovascular ultrasound is growing rapidly with new applications. While ultrasound contrast agents were initially used to overcome poor transcranial bone windows for identification of cerebral arteries, newgeneration microbubbles in combination with innovative contrast-specific ultrasound techniques now enable potential therapeutic procedures. This article will provide a review of recent and emerging developments along with patents in ultrasound technology and contrast-specific therapeutic techniques for cerebrovascular patients.
Spinelli
Mariacarmela
M
Department of Neurology - Institute of Experimental Neurology IRCCS San Raffaele, Milan, Italy. spinelli.marica@hsr.it
Demitri
Christian
C
Sannino
Alessandro
A
Peruzzotti-Jametti
Luca
L
Bacigaluppi
Marco
M
Comi
Giancarlo
G
Corea
Francesco
F
D000818:Animals; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D045423:Microbubbles / Q000639:trends; D014463:Ultrasonography
D003287:Contrast Media