Recombinant activated factor VII for massive hemoptysis in patients with cystic fibrosis.
Massive hemoptysis is a common complication in patients with cystic fibrosis (CF) and is associated with significant morbidity and mortality. Conventional treatment with antibiotic therapy and early bronchial artery embolization (BAE) is usually successful in achieving hemostasis in the majority of patients. Recombinant activated factor VII (rFVIIa), originally developed for use in patients with hemophilia, has emerged as a general hemostatic agent that is potentially useful in the management of many life-threatening bleeding conditions. In this article, we present four patients with CF lung disease and massive hemoptysis who were treated successfully with rFVIIa. We suggest that in patients with CF who present with massive hemoptysis, the use of rFVIIa can be considered in patients with refractory hemoptysis despite conventional therapy or as a temporizing therapy when BAE is not immediately available.
Lau
Edmund M T
EMT
Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Yozghatlian
Veronica
V
Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Kosky
Chris
C
Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Moriarty
Carmel
C
Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Dentice
Ruth
R
Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Waugh
Richard
R
Department of Radiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Torzillo
Paul J
PJ
Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Bye
Peter T
PT
Woolcock Institute of Medical Research and University of Sydney, Sydney, NSW, Australia; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia. Electronic address: peterb@med.usyd.edu.au.
D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications*; D004621:Embolization, Therapeutic; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006469:Hemoptysis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D055815:Young Adult
D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa