User-friendly stereoselective one-pot access to 1,4-diazepane derivatives by a cyclodehydrative three-component reaction with 1,3-dicarbonyls.
A multicomponent reaction of 1,3-dicarbonyls with 1,2-diamines and aromatic aldehydes is described for the direct stereoselective synthesis of 1,4-diazepane derivatives. Various reaction conditions were tested, including an efficient, user-friendly solvent- and catalyst-free procedure.
Sotoca
Enrique
E
Aix-Marseille Université-Institut des Sciences Moléculaires de Marseille UMR CNRS 6263 iSm2, Centre Saint Jérôme, Service 531, 13397, Marseille Cedex 20, France.
Allais
Christophe
C
Constantieux
Thierry
T
Rodriguez
Jean
J
D001381:Azepines; D017554:Carbon Compounds, Inorganic / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D012997:Solvents; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
D001381:Azepines; D017554:Carbon Compounds, Inorganic; D012997:Solvents; D014867:Water