title: The diarylquinoline R207910 is bactericidal against Mycobacterium leprae in mice at low dose and administered intermittently.
abstract: The diarylquinoline R207910 is profoundly bactericidal in a murine model of tuberculosis. Previously, R207910 was also found to be bactericidal for Mycobacterium leprae-infected mice during lag phase. Herein we evaluate the bactericidal efficacy of R207910 (1 to 120 mg/kg of body weight) when administered five times weekly, once weekly, and once monthly during logarithmic multiplication of M. leprae organisms. All treatments were found to be bactericidal, suggesting that both low and intermittent dosing with R207910 holds promise for leprosy patients.
authors: Leonard Wood Memorial, Cebu, the Philippines. ikgelber@hotmail.com
authors: Robert
authors: R
authors: Gelber
authors: Koen
authors: K
authors: Andries
authors: Rose Maria D
authors: RM
authors: Paredes
authors: Cora Evelyn S
authors: CE
authors: Andaya
authors: Jasmin
authors: J
authors: Burgos
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology*; D064687:Diarylquinolines; D004334:Drug Administration Schedule; D007918:Leprosy; D051379:Mice; D009166:Mycobacterium leprae / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D064687:Diarylquinolines; D011804:Quinolines; C493870:bedaquiline