Anti-angiogenic therapy in renal cell carcinoma.
Renal cell carcinoma (RCC) is one of the most common cancers in the United States. Recent achievements in translational research have lead to significant developments in treatment strategies for this malignancy. RCC is a richly vascular neoplasm. A better understanding of its biology has helped in the development of antiangiogenic therapy. Vascular endothelial growth factor (VEGF) is the most important molecular target in the treatment of RCC. Patents have been filed for anti-VEGF and other molecular pathways involved in the pathogenesis of RCC.
Sharma
Shree G
SG
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. drshreegopal@gmail.com
Nanda
Sudip
S
Longo
Santo
S
D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000235:genetics; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D016023:Integrins / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000235:genetics; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008954:Models, Biological; D053758:Nanoparticles / Q000627:therapeutic use; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000378:metabolism; D010330:Patents as Topic; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics
D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D016023:Integrins; D047908:Intracellular Signaling Peptides and Proteins; D042461:Vascular Endothelial Growth Factor A; D051794:Von Hippel-Lindau Tumor Suppressor Protein; C546842:MTOR protein, human; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases; D020782:Matrix Metalloproteinases