Age-related cognitive gains are mediated by the effects of white matter development on brain network integration.
A fundamental, yet rarely tested premise of developmental cognitive neuroscience is that changes in brain activity and improvements in behavioral control across adolescent development are related to brain maturational factors that shape a more efficient, highly-interconnected brain in adulthood. We present the first multimodal neuroimaging study to empirically demonstrate that maturation of executive cognitive ability is directly associated with the relationship of white matter development and age-related changes in neural network functional integration. In this study, we identified specific white matter regions whose maturation across adolescence appears to reduce reliance on local processing in brain regions recruited for conscious, deliberate cognitive control in favor of a more widely distributed profile of functionally-integrated brain activity. Greater white matter coherence with age was associated with both increases and decreases in functional connectivity within task-engaged functional circuits. Importantly, these associations between white matter development and brain system functional integration were related to behavioral performance on tests of response inhibition, demonstrating their importance in the maturation of optimal cognitive control.
Stevens
Michael C
MC
Olin Neuropsychiatry Research Center, Whitehall Building, The Institute of Living/Hartford Hospital, Hartford, CT 06106, USA. msteven@harthosp.org
Skudlarski
Pawel
P
Pearlson
Godfrey D
GD
Calhoun
Vince D
VD
D000293:Adolescent; D041923:Adolescent Development / Q000502:physiology; D000328:Adult; D000375:Aging / Q000502:physiology*; D016880:Anisotropy; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D003071:Cognition / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009483:Neuropsychological Tests; D013647:Task Performance and Analysis; D055815:Young Adult