title: Positively charged base surrogate for highly stable "base pairing" through electrostatic and stacking interactions.
abstract: "Base pairs" of cationic dyes (p-methylstilbazole) were incorporated into oligodeoxyribonucleotides (ODNs). This "base pair" greatly stabilized the duplex through electrostatic and stacking interactions. The melting temperature of modified ODN was higher than those of neutral dyes and native base pairs. Further stabilization of the duplex was observed when the number of cationic dyes increased.
authors: Graduate School of Engineering, Nagoya University, Furocho, Chikusa-ku, Nagoya 464-8603, Japan.
authors: Hiromu
authors: H
authors: Kashida
authors: Hidehiro
authors: H
authors: Ito
authors: Taiga
authors: T
authors: Fujii
authors: Takamitsu
authors: T
authors: Hayashi
authors: Hiroyuki
authors: H
authors: Asanuma
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry; D020029:Base Pairing; D002072:Butylene Glycols / Q000737:chemistry; D008968:Molecular Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D000605:Amino Alcohols; D002072:Butylene Glycols; D009841:Oligonucleotides; C532652:threoninol