title: Quantitative assessment of regional systolic and diastolic functions and temporal heterogeneity of myocardial contraction in patients with myocardial infarction using cine magnetic resonance imaging and Fourier fitting.
abstract: OBJECTIVE
  The objective of this study is to determine regional left ventricle (LV) function and temporal heterogeneity of LV wall contraction by analyzing regional time-volume curve (TVC) after Fourier fitting and to assess altered systolic and diastolic functions and temporal indices of myocardial contraction in infarcted segments in comparison with noninfarcted myocardium in patients with myocardial infarction (MI).
  
  
  METHODS
  Steady-state cine magnetic resonance (MR) and late gadolinium-enhanced (LGE) MR images were acquired using a 1.5-T MR system in 60 patients with MI. Regional LV function was determined by analyzing regional TVC in 16 segments. The fitted regional TVC was generated by Fourier curve fitting with five harmonics. Regional LV ejection fraction (EF), peak ejection rate (PER), peak filling rate (PFR), time to end-systole and time to peak filling (TPF) were determined from TVC and the first derivative curve.
  
  
  RESULTS
  On LGE MR imaging (MRI), MI was observed in 307 of 960 segments (32.0%). Regional EF and PER averaged in LGE segments were 49.3+/-14.5% and 2.83+/-0.65 end-diastolic volume (EDV)/s, significantly lower than those in normal segments (66.7+/-11.9% and 3.63+/-0.60 EDV/s, P<.001 and P<.01, respectively). In addition, regional PFR, an index of diastolic function, was significantly reduced in LGE segments (1.94+/-0.54 vs. 2.86+/-0.68 EDV/s, P<.01). Time to end-systole and TPF were significantly greater in LGE segments (380.2+/-57.6 and 169.3+/-45.4 ms) than in normal segments (300.9+/-55.1 and 132.3+/-43.0 ms, P<.01 and P<.01, respectively).
  
  
  CONCLUSIONS
  Analysis of regional TVC on cine MRI after Fourier fitting allows quantitative assessment of regional systolic and diastolic LV functions and temporal heterogeneity of LV wall contraction in patients with MI.
authors: Diagnostic Imaging Center, Seirei Mikatahara General Hospital, Hamamatsu, Shizuoka 433-8558, Japan. tnatsume@sis.seirei.or.jp
authors: Takahiro
authors: T
authors: Natsume
authors: Tomoyasu
authors: T
authors: Amano
authors: Yasuo
authors: Y
authors: Takehara
authors: Takashi
authors: T
authors: Ichihara
authors: Kan
authors: K
authors: Takeda
authors: Hajime
authors: H
authors: Sakuma
mesh_terms: D000368:Aged; D003971:Diastole; D005260:Female; D005583:Fourier Analysis; D005682:Gadolinium / Q000494:pharmacology; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology; D015203:Reproducibility of Results; D013599:Systole; D016277:Ventricular Function, Left
chemical_list: D005682:Gadolinium