Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).
Benjamin
Emelia J
EJ
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. emelia@bu.edu
Rice
Kenneth M
KM
Arking
Dan E
DE
Pfeufer
Arne
A
van Noord
Charlotte
C
Smith
Albert V
AV
Schnabel
Renate B
RB
Bis
Joshua C
JC
Boerwinkle
Eric
E
Sinner
Moritz F
MF
Dehghan
Abbas
A
Lubitz
Steven A
SA
D'Agostino
Ralph B
RB
Lumley
Thomas
T
Ehret
Georg B
GB
Heeringa
Jan
J
Aspelund
Thor
T
Newton-Cheh
Christopher
C
Larson
Martin G
MG
Marciante
Kristin D
KD
Soliman
Elsayed Z
EZ
Rivadeneira
Fernando
F
Wang
Thomas J
TJ
Eiríksdottir
Gudny
G
Levy
Daniel
D
Psaty
Bruce M
BM
Li
Man
M
Chamberlain
Alanna M
AM
Hofman
Albert
A
Vasan
Ramachandran S
RS
Harris
Tamara B
TB
Rotter
Jerome I
JI
Kao
W H Linda
WH
Agarwal
Sunil K
SK
Stricker
Bruno H Ch
BH
Wang
Ke
K
Launer
Lenore J
LJ
Smith
Nicholas L
NL
Chakravarti
Aravinda
A
Uitterlinden
André G
AG
Wolf
Philip A
PA
Sotoodehnia
Nona
N
Köttgen
Anna
A
van Duijn
Cornelia M
CM
Meitinger
Thomas
T
Mueller
Martina
M
Perz
Siegfried
S
Steinbeck
Gerhard
G
Wichmann
H-Erich
HE
Lunetta
Kathryn L
KL
Heckbert
Susan R
SR
Gudnason
Vilmundur
V
Alonso
Alvaro
A
Kääb
Stefan
S
Ellinor
Patrick T
PT
Witteman
Jacqueline C M
JC
D001281:Atrial Fibrillation / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D015201:Meta-Analysis as Topic; D009154:Mutation / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015203:Reproducibility of Results; D044465:White People / Q000235:genetics*
D018398:Homeodomain Proteins; C071660:ZFHX3 protein, human