Developments in autonomic research: a review of the latest literature.
Small-diameter afferents do not just subserve pain and temperature sensibilities, important for protection of the body though they are: there is a system of low-threshold unmyelinated afferents that respond to light stroking (C-tactile afferents) and they are believed to subserve the affective components of touch. Patients with large-fibre sensory neuropathies exhibit skin sympathetic responses to stroking, and report the stimuli as feeling pleasant. Moreover, the posterior insula is activated. Patients with small-diameter sensory neuropathies, specifically those with congenital insensitivity to pain, suffer from cumulative injuries that can lead to joint degeneration. There is evidence that the nociceptive (and sympathetic) axons die because nerve growth factor is not being produced by the target tissues; patients with congenital insensitivity to pain have mutations in the NTRK1 gene, the gene responsible for producing the TrkA receptor, but there is also evidence for mutations in the SCN9A gene, which codes for a specific subunit of the voltage-gated sodium channel. Specific mutations, leading to clusters of cases of congenital insensitivity to pain, have been found in several geographical locations, with several genetic mutations having been documented. Interestingly, even patients with congenital insensitivity to pain, despite having never experienced pain, can still empathise with the pain in others-we do not need to feel pain in order to empathise, but we do need to feel pain in order to ensure that our body looks after itself.
Macefield
Vaughan G
VG
School of Medicine, University of Western Sydney, Penrith South DC, NSW 1797, Australia. v.macefield@uws.edu.au
D000344:Afferent Pathways / Q000502:physiology; D001341:Autonomic Nervous System / Q000502:physiology*; D004525:Efferent Pathways / Q000502:physiology; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000235:genetics / Q000378:metabolism; D006801:Humans; D062556:NAV1.7 Voltage-Gated Sodium Channel; D020932:Nerve Growth Factor / Q000378:metabolism; D010146:Pain / Q000503:physiopathology*; D000699:Pain Insensitivity, Congenital / Q000235:genetics* / Q000378:metabolism; D010523:Peripheral Nervous System Diseases / Q000235:genetics* / Q000378:metabolism; D020917:Receptor, trkA / Q000235:genetics / Q000378:metabolism; D015222:Sodium Channels / Q000378:metabolism; D050916:TRPV Cation Channels / Q000235:genetics / Q000378:metabolism; D014110:Touch / Q000502:physiology*
D062556:NAV1.7 Voltage-Gated Sodium Channel; C486866:SCN9A protein, human; D015222:Sodium Channels; D050916:TRPV Cation Channels; D020932:Nerve Growth Factor; D020917:Receptor, trkA