Essential oil of Lindera neesiana fruit: chemical analysis and its potential use in topical applications.
The composition of the essential oil of Lindera neesiana Kurz fruit was examined by GC-MS, (1)H, (13)C and bidimensional NMR techniques (HMQC, HMBC, COSY, TOCSY). Forty compounds were identified, representing approximately 86% of the oil: Z-citral (15.08%), E-citral (11.89%), eucalyptol (8.75%), citronellal (6.72%), alpha-pinene (6.63%) and beta-pinene (5.61%) were the major components. The essential oil of L. neesiana fruit showed significant antimicrobial activity against Staphylococcus aureus and Candida albicans at non-cytotoxic doses in human keratinocytes, suggesting possible topical applications. GRAPHICAL ABSTRACT: The essential oil of Lindera neesiana was investigated by GC-MS and NMR techniques. Its biological activities suggest possible topical applications.
Comai
Stefano
S
Department of Pharmaceutical Sciences, University of Padova, Padova, Italy.
Dall'Acqua
Stefano
S
Grillo
Alessia
A
Castagliuolo
Ignazio
I
Gurung
Khilendra
K
Innocenti
Gabbriella
G
D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000302:isolation & purification*; D002478:Cells, Cultured; D005638:Fruit / Q000737:chemistry; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects; D027443:Lindera / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity
D000891:Anti-Infective Agents, Local; D009822:Oils, Volatile; D010936:Plant Extracts