Antagonism of gamma-hydroxybutyrate-induced hypersynchronization in the ECoG of the rat by anti-petit mal drugs.
Administration of gamma-hydroxybutyrate (GHB) (200 mg/kg i.p.) in rats evoked a hypersynchronous electrocorticogram pattern which was antagonized by specific anti-petit mal agents, while other antiepileptic drugs exerted no influence, or even potentiated the effect of GHB. The specific sensitivity of the GHB-induced hypersynchrony to anti-petit mal agents suggests a possible use of this effect as a model for testing potential anti-petit mal agents.
Godschalk
M
M
Department of Pharmacology, Faculty of Medicine, Erasmus University Rotterdam, P.O. Box 1738, Rotterdam, The Netherlands.
Dzoljic
M R
MR
Bonta
I L
IL