title: Epoetin alfa reduces blood transfusion requirements in patients with intertrochanteric fracture.
abstract: OBJECTIVE
  The purpose of this study is to identify the potential benefits or complications from the use of epoetin alfa in patients with intertrochanteric fracture.
  
  
  METHODS
  Seventy-nine patients who sustained an intertrochanteric fracture were divided into 2 groups. One group received 10 daily doses of 20 000 IU of epoetin alfa beginning from the day of trauma, whereas the control group received placebo.
  
  
  RESULTS
  We found a statistically significant difference in the required units of allogenic blood used between the 2 groups (P = .034). The group that received epoetin alfa also showed an elevation of hematocrit and hemoglobin values, which was statistically significant at the seventh postoperative day (P = .019 and .015, respectively) compared to the control group. No complications were evident during our study.
  
  
  CONCLUSIONS
  Patients with intertrochanteric fractures seem to benefit from the use of epoetin alfa because it is safe and reduces the need for blood transfusions.
authors: Department of Orthopaedics, General Hospital of Levadia, Levadia, Greece.
authors: Konstantinos
authors: K
authors: Kateros
authors: Vasileios I
authors: VI
authors: Sakellariou
authors: Ioannis P
authors: IP
authors: Sofianos
authors: Panayiotis J
authors: PJ
authors: Papagelopoulos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D000068817:Epoetin Alfa; D004921:Erythropoietin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006397:Hematinics / Q000627:therapeutic use*; D006400:Hematocrit / Q000706:statistics & numerical data; D006454:Hemoglobins / Q000187:drug effects; D006620:Hip Fractures / Q000097:blood / Q000628:therapy*; D006801:Humans; D008297:Male; D011184:Postoperative Period; D011994:Recombinant Proteins; D016896:Treatment Outcome
chemical_list: D006397:Hematinics; D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin; D000068817:Epoetin Alfa