Immunization with peptide-protein conjugates: impact on benchmarking B-cell epitope prediction for vaccine design.
Benchmarking B-cell epitope prediction for vaccine design is meaningful if based on empirical reference data pertaining to cross-reactivities of antipeptide antibodies with native protein antigens; yet it is complicated by such data acquired using antibodies raised against peptide-protein conjugates, as peptide-protein conjugation can differentially suppress antibody responses to peptide epitopes.
Caoili
Salvador Eugenio C
SE
Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Philippines. badong@post.upm.edu.ph
D000595:Amino Acid Sequence; D000818:Animals; D015195:Drug Design; D018985:Epitopes, B-Lymphocyte / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D006801:Humans; D053583:Interleukin-1beta / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D015233:Models, Statistical; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D012372:ROC Curve; D011817:Rabbits; D051381:Rats; D013816:Thermodynamics; D014612:Vaccines / Q000235:genetics / Q000276:immunology*
D018985:Epitopes, B-Lymphocyte; D053583:Interleukin-1beta; D010455:Peptides; D014612:Vaccines