Lipoprotein lipase and premature coronary artery disease.
OBJECTIVE
This study investigates the relationship between post-heparin plasma lipoprotein lipase (LPL) activity, chronic inflammation and premature stable coronary artery disease (CAD) in male patients.


RESULTS
132 male patients (< 55 years) with documented stable CAD (cases) and 130 male subjects without CAD were enrolled. Cases had higher values of high-sensitivity C-reactive protein (hs-CRP) and lower LPL activity [(5.31 +/- 3.06) mg/l vs. (2.67 +/- 1.01) mg/l, P < 0.01; (27.39 +/- 6.71) nmol x ml(-1) x min(-1) vs. (37.06 +/- 7.22) nmol x ml(-1) x min(-1), P < 0.01, respectively]. LPL activity was inversely associated with hs-CRP and triglycerides (TG), and positively associated with HDL-C (r = -0.761, P < 0.001; r = -0.339, P < 0.001; r = 0.217, P < 0.05; respectively) in cases. In multivariate analysis, higher values of hs-CRP (OR 1.45, 95% CI: 1.083-1.951; P = 0.013), BMI, LDL-C and hypertension were significant predictors of premature stable CAD in male patients. Higher LPL activity decreases risk of premature stable CAD (OR 0.87, 95% CI: 0.809-0.933; P = 0.000). LPL activities decreased with the increased number of significantly stenosed vessels (P < 0.05).


CONCLUSIONS
LPL activity and hs-CRP are significant predictors of premature stable CAD in male patients and are inversely correlated.
Chen
Zhong
Z
Department of Cardiology, Affiliated ZhongDa Hospital of Southeast University, NO. 87 Dingjiaqiao, Hunan Road, Nanjing 210009, PR China. zhongchen7498@sina.com.cn
Ma
Genshan
G
Zhang
Xiaoli
X
Wang
Jiahong
J
D000328:Adult; D000367:Age Factors; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000201:enzymology* / Q000453:epidemiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D013223:Statistics as Topic; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D002097:C-Reactive Protein; D008071:Lipoprotein Lipase