Sex steroid and tropic hormone levels may be associated with postoperative prognosis of vitrectomy in Korean postmenopausal women: a pilot study.
OBJECTIVE
The aim of this study was to evaluate the postoperative prognostic value of sex hormones and related biochemical markers for vitrectomy in postmenopausal Korean women.


METHODS
Twenty-three postmenopausal women undergoing vitrectomy who had not received hormone therapy were recruited. Before vitrectomy, hormonal profile such as follicle-stimulating hormone, estradiol, testosterone, tumor markers, and biochemical markers including homocysteine, glycosylated hemoglobin, protein, albumin, and lipid panel was measured. These parameters were correlated with ophthalmologic outcomes such as intraocular pressure, preoperative and postoperative visual acuity, and the visual improvement after surgery.


RESULTS
Follicle-stimulating hormone showed a positive correlation with the logarithm of the minimal angle of resolution value of postoperative visual acuity (Pearson's correlation, 0.583; P = 0.009). This significance was maintained after age or preoperative visual acuity was adjusted (P = 0.006 and P = 0.013, respectively). Testosterone also showed a positive correlation with intraocular pressure before and after adjustment for age (P = 0.027 and P = 0.033, respectively).


CONCLUSIONS
Sex steroid and tropic hormones may be associated with postoperative ophthalmologic outcomes in the postmenopausal women undergoing vitrectomy. Further larger scale studies will be necessary to confirm these preliminary results.
Yu
Hyeong Gon
HG
Department of Ophthalmology, Seoul National University, Seoul, Korea.
Ku
Seung-Yup
SY
Choi
Jin
J
Kim
Hoon
H
Suh
Chang Suk
CS
Kim
Seok Hyun
SH
Choi
Young Min
YM
Kim
Jung Gu
JG
Moon
Shin Yong
SY
D000368:Aged; D003687:Dehydroepiandrosterone / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood*; D006801:Humans; D007429:Intraocular Pressure; D007723:Korea; D008875:Middle Aged; D010865:Pilot Projects; D017698:Postmenopause / Q000097:blood*; D011379:Prognosis; D020127:Recovery of Function; D013739:Testosterone / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D014792:Visual Acuity; D014821:Vitrectomy / Q000534:rehabilitation*; D000509:alpha-Fetoproteins / Q000032:analysis
D043373:Follicle Stimulating Hormone, Human; D000509:alpha-Fetoproteins; D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol; D013972:Thyrotropin