[The expression and significance of activator protein-1 and matrix metalloproteinases in the human heart post acute myocardial infarction].
OBJECTIVE
To investigate the expression and significance of activator protein-1 (AP-1) and matrix metalloproteinases (MMPs) in acute myocardial infarction (AMI) subjects.


METHODS
Immunohistochemical techniques were used to detect the subunit of AP-1 (c-Jun), MMP-2 and MMP-9 in human AMI and normal heart tissue and the expressions of c-Jun and MMPs were measured with computer image analysis system.


RESULTS
(1) There were expressions of c-Jun, MMP-2 and MMP-9 in normal heart tissue, mainly in myocardial cells and cardiac fibroblasts, and their expressions in AMI myocardial tissues were all significantly higher than those in normal myocardial tissues (P < 0.05). (2) The level of MMP-9 expression was significantly and positively correlated with c-Jun in AMI heart tissue (r = 0.773, P < 0.01).


CONCLUSIONS
The expressions of AP-1 and MMPs increase in human myocardial infarction. These findings suggest that AP-1 transcription activation pathway and MMPs may play an important role in ventricular remodeling of myocardial infarction.
Xie
Shuang-Lun
SL
Department of Cardiology, the Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China.
Wang
Jing-Feng
JF
Nie
Ru-Qiong
RQ
Yuan
Wo-Liang
WL
Li
Fei
F
Lin
Yong-Qing
YQ
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism* / Q000503:physiopathology; D018808:Transcription Factor AP-1 / Q000378:metabolism*; D020257:Ventricular Remodeling
D018808:Transcription Factor AP-1; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9