A new bifunctional chelator for copper radiopharmaceuticals: a cage amine ligand with a carboxylate functional group for conjugation to peptides.
A new sarcophagine cage amine ligand with a pendent carboxylate functional group has been synthesised; the ligand has been conjugated to tumour targeting peptides ([Tyr3]-octreotate and [Lys3]-bombesin) and the conjugates radiolabelled with copper-64.
Ma
Michelle T
MT
School of Chemistry, University of Melbourne, Parkville, Melbourne, Victoria, 3010, Australia.
Karas
John A
JA
White
Jonathan M
JM
Scanlon
Denis
D
Donnelly
Paul S
PS
D000588:Amines / Q000737:chemistry*; D000818:Animals; D002264:Carboxylic Acids / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D010455:Peptides / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry*
D000588:Amines; D002264:Carboxylic Acids; D002614:Chelating Agents; D003432:Cross-Linking Reagents; D008024:Ligands; D010455:Peptides; D019275:Radiopharmaceuticals; D003300:Copper