title: The effect of varicocele on seminal plasma and serum inhibin-B levels in adolescent and adult men.
abstract: BACKGROUND
  In the present study, the relationship between serum/seminal plasma and serum FSH and seminal parameters was evaluated in adults and adolescent varicocele patients and compared with normal fertile cases.
  
  
  METHODS
  A total of 50 adult patients with varicocele (Group-1) and 50 adolescents with varicocele (Group-2) were enrolled into the study. Fifty fertile cases without any scrotal pathology were accepted as control group (Group-3). Serum gonadotropin, sex steroids and serum and seminal plasma inhibin-B levels were measured, and semen analysis was performed after 2 and 5 days of sexual abstinence. All parameters were compared among three groups by using one-way ANOVA test.
  
  
  RESULTS
  There were statistically significant differences among three groups on seminal parameters due to disturbed spermatogenesis in patients with varicocele (P < 0.05). However, there were not statistical differences between serum and seminal plasma Inhibin-B levels among groups. In varicocele patients, serum inhibin-B levels showed negative and significant correlation only with FSH levels (r = -0.253, P = 0.011). On the contrary, neither serum nor seminal plasma inhibin-B levels showed significant correlation with seminal parameters.
  
  
  CONCLUSIONS
  While varicocele affects different mechanisms in the regulation of spermatogenesis in testes, serum and seminal plasma inhibin-B have not any role in decreased spermatogenesis in varicocele.
authors: Department of Urology, Faculty of Medicine, University of Kirikkale, Kirikkale, Turkey. mmbasar@hotmail.com
authors: M Murad
authors: MM
authors: Basar
authors: Ucler
authors: U
authors: Kisa
authors: Devrim
authors: D
authors: Tuglu
authors: Murat
authors: M
authors: Kacmaz
authors: Halil
authors: H
authors: Basar
mesh_terms: D000293:Adolescent; D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000032:analysis*; D008297:Male; D012661:Semen / Q000737:chemistry*; D014646:Varicocele / Q000097:blood*; D055815:Young Adult
chemical_list: C422364:inhibin B; D007265:Inhibins; D005640:Follicle Stimulating Hormone