title: Docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer.
abstract: BACKGROUND
  The safety and efficacy of docetaxel plus S-1 combination chemotherapy as a first-line treatment in patients with advanced or recurrent gastric cancer was verified retrospectively.
  
  
  METHODS
  Eighteen patients with advanced or recurrent gastric cancer were enrolled. The regimen used was intravenous docetaxel, 40 mg/m(2), on day 1 and oral S-1, 80 mg/m(2)/day, on days 1-14 every three weeks.
  
  
  RESULTS
  In total 101 cycles were administered. One and 11 patients achieved complete and partial responses, while six and zero patients showed stable and progressive disease, respectively. The median time to progression (TTP) and median overall survival were 7.0 and 14.3 months, respectively. Neutropenia was the most common grade 3/4 hematological toxicity. Nausea and stomatitis were the most common grade 3 nonhematological toxicities. No treatment-related death was observed.
  
  
  CONCLUSIONS
  Docetaxel plus S-1 combination is an active and tolerable regimen as a first-line treatment in patients with advanced or recurrent gastric cancer.
authors: Department of Surgery, Saiseikai Hiroshima Hospital, Aki-gun, Hiroshima 731-4311, Japan. yatsutani@msn.com
authors: Yasuhiro
authors: Y
authors: Tsutani
authors: Masahiro
authors: M
authors: Ohara
authors: Takahisa
authors: T
authors: Suzuki
authors: Kazuhito
authors: K
authors: Minami
authors: Eiji
authors: E
authors: Miyahara
authors: Akira
authors: A
authors: Kameda
authors: Yoshihiro
authors: Y
authors: Noso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000077143:Docetaxel; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy*; D016019:Survival Analysis; D043823:Taxoids / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid