Application of a reservoir-type calcitriol transdermal patch in dairy cattle.
Our objective was to evaluate the effects of a reservoir-type calcitriol (5 mg/animal) transdermal patch on plasma calcitriol and calcium (Ca) concentrations in dairy cattle. A group of six heifers received three different types of patches: an encapsulated reservoir solution containing calcitriol alone (CAL), calcitriol with dodecylamine (CAL+D), or vehicle (CONT). The patches were applied to the skin of the tail for duration of 2 days at intervals of at least 3 weeks. Cattle that received CAL or CAL+D showed significant increases in plasma calcitriol and Ca concentrations on day 2 and days 2 and 3, respectively. The areas under the plasma concentration-time curve (AUC) values for plasma calcitriol and Ca in the CAL and CAL+D groups increased significantly compared to the CONT group. The data of this study describe evidence of measurable transdermal absorption of exogenous calcitriol from a patch and its sufficient biological action to elevate plasma Ca concentrations.
Yamagishi
Norio
N
Department of Veterinary Clinical Medicine, Faculty of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan. yamagisi@iwate-u.ac.jp
Namioka
Toru
T
Okura
Norimoto
N
Sato
Shigeru
S
Kim
Danil
D
Furuhama
Kazuhisa
K
Naito
Yoshihisa
Y
D000279:Administration, Cutaneous; D000588:Amines / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D019540:Area Under Curve; D002117:Calcitriol / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D002118:Calcium / Q000097:blood; D002417:Cattle / Q000097:blood / Q000378:metabolism*; D005260:Female; D011897:Random Allocation; D013501:Surface-Active Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014815:Vitamins / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics
D000588:Amines; D013501:Surface-Active Agents; D014815:Vitamins; D002117:Calcitriol; D002118:Calcium; C003935:dodecylamine