title: Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature adult Trichuris vulpis infections in dogs.
abstract: This paper reports on the efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender tablets for dogs) against mature and immature adult whipworms (Trichuris vulpis) at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight in dogs. Three randomised, blinded and controlled laboratory studies with naturally or experimentally infected dogs were performed. The first study was conducted as a dose determination study in experimentally infected dogs using three different dose levels, i.e., 0.5x, 1x and 2x the minimum therapeutic dose. Two further studies confirmed the efficacy of emodepside plus praziquantel tablets against mature and immature adult T. vulpis at the recommended minimum dose. In all three studies, the efficacy against mature and immature adult T. vulpis was >99%. No side effects of the treatment were observed. It is concluded that the emodepside plus praziquantel tablet is an effective and safe treatment against mature and immature adult stages of T. vulpis in dogs.
authors: Bayer Animal Health GmbH, Leverkusen, Germany.
authors: Annette
authors: A
authors: Schimmel
authors: Gertraut
authors: G
authors: Altreuther
authors: Iris
authors: I
authors: Schroeder
authors: Samuel
authors: S
authors: Charles
authors: Larry
authors: L
authors: Cruthers
authors: Dawid J
authors: DJ
authors: Kok
authors: Friederike
authors: F
authors: Kraemer
authors: Klemens J
authors: KJ
authors: Krieger
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D047630:Depsipeptides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004311:Double-Blind Method; D005243:Feces / Q000469:parasitology; D010270:Parasite Egg Count; D010919:Placebos / Q000008:administration & dosage; D011223:Praziquantel / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013607:Tablets / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome; D014257:Trichuriasis / Q000188:drug therapy / Q000662:veterinary*; D014258:Trichuris / Q000187:drug effects*
chemical_list: D000871:Anthelmintics; D047630:Depsipeptides; D010919:Placebos; D013607:Tablets; D011223:Praziquantel; C468987:emodepside