[Fetal anomalies in second trimester in recent ten years: clinical analysis of 116 cases].
OBJECTIVE
To evaluate the prevalence of fetal anomalies in recent 10 years and explore the effective methods of early diagnosis and treatment.


METHODS
The clinical and pathological data of 116 pregnant women who underwent induced abortion in the second trimester due to fetal anomalies 1998 - 2007 were analyzed retrospectively.


RESULTS
The fetal anomaly rate in the period 2003 - 2997 was 8.7 per thousand, significantly higher than that in the period 1998 - 2002 (3.1 per thousand, P < 0.001). The diagnostic methods of fetal anomalies used during the period 2003 - 2007 did not show significant differences compared with those used during the period 1998 - 2002. The gestational week when the fetal anomalies were detected in 2002 - 2007 was 19.3 weeks, not significantly preceded compared with that during 1998 - 2002 (22.4 weeks, P > 0.05). The top 5 fetal anomalies with high incidence rates were Down' syndrome, anencephalus, lip/palate cleft, fatal cystic hygroma of the neck, and cardiac anomalies. There were 30 cases of advanced maternal age over 35 years, 60.0% of whose fetuses showed chromosome abnormality.


CONCLUSIONS
The incidence of fetal anomalies increases in recent years. The risk of fetal anomalies is high in the pregnant women in elder age. Pregnancy in advanced maternal age show high risk to occur fetal anomaly. Better approaches to diagnose fetal anomaly earlier are still to be found.
Han
Xiao-Yan
XY
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Jin
Li
L
Fan
Guang-Sheng
GS
Xiang
Yang
Y
Liu
Xin-Yan
XY
Hao
Na
N
Cui
Quan-Cai
QC
D000013:Congenital Abnormalities / Q000175:diagnosis*; D005260:Female; D006801:Humans; D015994:Incidence; D008423:Maternal Age; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis