Potential of vitamin E as an antioxidant adjunct in Wilson's disease.
Wilson's disease is a rare genetic illness of copper metabolism, which leads to copper-overload in mitochondria and organ damage, especially to the liver. Oxidative stress is central to the pathogenesis and a case is briefly made for rigorous trials of vitamin E as an antioxidant adjunct based on earlier corollary studies of its levels in the blood and liver of Wilson's disease patients and its effects in animal models of the illness.
Fryer
Michael J
MJ
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK. mfryer@essex.ac.uk
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D014810:Vitamin E