Ethanolic extract of Clerodendrum violaceum Gürke leaves enhances kidney function in mouse model of malaria.
Evaluation of the effects of daily oral administration of ethanolic extract of C. violaceum leaves (13 mg/kg body weight) for 5 days on some kidney function indices of uninfected and Plasmodium berghei-infected mice was done on days 3, 8 and 14 post-infection. The indices studied include serum urea and creatinine concentrations with the specific activities of alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase in the kidney. Treatment of P. berghei-infected mice with ethanolic extract of C. violaceum leaves (13 mg/kg body weight) for 5 days was able to ameliorate significantly the alterations in the various parameters observed in infected untreated mice, comparing favourably with chloroquine treatment in most cases. Administration of extract to uninfected mice had no significant effect on both serum and kidney parameters compared to the uninfected control. The results suggest that the ethanolic extract of C. violaceum leaves does not adversely affect kidney function at the dose used in traditional medicine for the treatment of malaria but rather enhances it.
Zailani
Ahmed H
AH
Department of Biochemistry, University of Ilorin, Ilorin, Kwara State, Nigeria.
Balogun
Elizabeth A
EA
Adebayo
Joseph O
JO
D000818:Animals; D032409:Clerodendrum / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008288:Malaria / Q000469:parasitology / Q000503:physiopathology*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D010962:Plasmodium berghei / Q000302:isolation & purification
D010936:Plant Extracts