Determination of HIV drugs in biological matrices: a review.
The present paper reviews the recent advances on the determination of antiretroviral drugs against the human immunodeficiency virus (HIV). Methods have been reviewed with special emphasis on the principal analytical strategies for dealing with clinical samples as well as the determination of the newest drugs. The most critical steps of the analytical procedures including the sample treatment, separation and validation have been discussed. Finally, a brief description of representative applications is given.
Checa
Antonio
A
Department of Analytical Chemistry, University of Barcelona, Diagonal 647, 08028 Barcelona, Spain.
Oliver
Ramon
R
Hernández-Cassou
Santiago
S
Saurina
Javier
J
D053000:Analytic Sample Preparation Methods; D019380:Anti-HIV Agents / Q000032:analysis* / Q000097:blood / Q000302:isolation & purification; D016903:Drug Monitoring; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans
D019380:Anti-HIV Agents