Integr-ating IL-1 alpha in antiviral host defenses.
Adenoviral vectors used in gene therapy induce inflammation, although the underlying mechanisms are currently unknown. In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity.
Fitzgerald
Katherine A
KA
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. kate.fitzgerald@umassmed.edu
D000256:Adenoviridae / Q000276:immunology*; D000818:Animals; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000276:immunology*; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology / Q000821:virology*; D039661:Integrin beta3 / Q000276:immunology*; D053582:Interleukin-1alpha / Q000276:immunology*; D051379:Mice
D039661:Integrin beta3; D053582:Interleukin-1alpha