title: Clinical significance of measuring urinary sulfated bile acids in adult patients with hepatobiliary diseases.
abstract: OBJECTIVE
  Measurement of urinary sulfated bile acid (USBA) level is a simple urine test that reflects the degree of cholestasis in newborns. The aim of this study was to clarify the clinical significances of this test for liver diseases in adults.
  
  
  METHODS
  We examined the relationship between USBA level in a urine sample by enzymatic assay and clinical parameters and postoperative complications in 27 patients with hepatobiliary diseases who underwent surgical procedures between 2002 and 2007.
  
  
  RESULTS
  Mean USBA in all patients before surgery was 39.8 +/- 64.0 micromol/L (median value was 6.6). USBA level was increased in patients with cholestasis. USBA level was significantly correlated with serum total bile acid, total bilirubin level and serum hyaluronic acid level (r = 0.850, 0.602 and 0.504, respectively) (p < 0.05) and, furthermore, tended to be correlated with liver-uptake ratio (LHL15) by technetium-99m galactosyl human serum albumin (99SmTc-GSA) scintigraphy and alanine aminotransferase level (r = -0.469 and 0.436, respectively but not significant). USBA level tended to be associated with postoperative uncontrolled ascites (p = 0.050, not significant). Postoperative USBA level by day 7 was not changed; however, USBA level in patients with cholestatic diseases was decreased.
  
  
  CONCLUSIONS
  USBA is a simple and sensitive noninvasive test for cholestasis and also useful to predict postoperative uncontrolled ascites after hepatic resections.
authors: Division of Surgical Oncology Department of Translational Medical Sciences Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 8528501, Japan. a-nanasm@net.nagasaki-u.ac.jp
authors: Atsushi
authors: A
authors: Nanashima
authors: Masayuki
authors: M
authors: Obatake
authors: Yorihisa
authors: Y
authors: Sumida
authors: Takafumi
authors: T
authors: Abo
authors: Yusuke
authors: Y
authors: Yamane
authors: Masahito
authors: M
authors: Nomura
authors: Inamura
authors: I
authors: Yuhio
authors: Terumitsu
authors: T
authors: Sawai
authors: Hiroaki
authors: H
authors: Takeshita
authors: Shigekazu
authors: S
authors: Hidaka
authors: Toru
authors: T
authors: Yasutake
authors: Takeshi
authors: T
authors: Nagayasu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D001201:Ascites / Q000652:urine; D001647:Bile Acids and Salts / Q000097:blood / Q000652:urine*; D001660:Biliary Tract Diseases / Q000601:surgery / Q000652:urine*; D001663:Bilirubin / Q000378:metabolism; D015415:Biomarkers / Q000652:urine; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008107:Liver Diseases / Q000601:surgery / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000652:urine; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity
chemical_list: D001647:Bile Acids and Salts; D015415:Biomarkers; C020980:bile acid sulfates; D006820:Hyaluronic Acid; D000410:Alanine Transaminase; D001663:Bilirubin