title: [Serum C-reactive protein levels and lipid profiles concentrations in moderate to severe periodontitis and coronary heart disease: a comparative study].
abstract: OBJECTIVE
  To investigate the correlation between moderate to severe periodontitis and coronary heart disease (CHD) and to examine the serum C-reactive protein (CRP) levels in subjects with CHD and/or moderate to severe periodontitis.
  
  
  METHODS
  Serum CRP levels, serum lipids [low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), total cholesterol (TC) and triglyceride (TG)] and clinical periodontal parameters [clinical attachment loss (CAL), probing depth (PD), and bleeding on probing (BOP)] were measured and analyzed in coexistent moderate to severe periodontitis and CHD patients (n = 47), CHD patients (n = 28), moderate to severe periodontitis patients (n = 40), and healthy subjects (n = 40).
  
  
  RESULTS
  The serum CRP levels in control group, moderate to severe periodontitis patients, CHD patients and patients with both diseases were (1.30 +/- 0.15), (2.44 +/- 0.18), (5.99 +/- 0.82) and (6.88 +/- 0.71) mg/L, respectively. The differences among these four groups were significant (P < 0.001). The multivariate logistic regression revealed that moderate to severe periodontitis patients exhibited markedly elevated odds of having CHD (OR = 2.417, 95% CI: 1.126 - 6.659). The total cholesterol levels were also significantly different among the four groups (P = 0.017).
  
  
  CONCLUSIONS
  The moderate to severe periodontitis was associated with elevated serum CRP levels which may in turn affect the initiation and progression of CHD, and may be a risk factor for CHD.
authors: Department of Periodontology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
authors: Juan
authors: J
authors: Liu
authors: Ya-Fei
authors: YF
authors: Wu
authors: Yi
authors: Y
authors: Ding
authors: Song
authors: S
authors: Ge
authors: Li
authors: L
authors: Rao
authors: Hong
authors: H
authors: Tang
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood*
chemical_list: D008055:Lipids; D002097:C-Reactive Protein