Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.
Nosocomial outbreaks attributable to glutaraldehyde-resistant, rapidly growing mycobacteria are increasing. Here, evidence is provided that defects in porin expression dramatically increase the resistance of Mycobacterium smegmatis and Mycobacterium chelonae to glutaraldehyde and another aldehyde disinfectant, ortho-phthalaldehyde. Since defects in porin activity also dramatically increased the resistance of M. chelonae to drugs, there is thus some concern that the widespread use of glutaraldehyde and ortho-phthalaldehyde in clinical settings may select for drug-resistant bacteria.
Svetlíková
Zuzana
Z
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523-1682, USA.
Skovierová
Henrieta
H
Niederweis
Michael
M
Gaillard
Jean-Louis
JL
McDonnell
Gerald
G
Jackson
Mary
M
D000995:Antitubercular Agents / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005976:Glutaral / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D016926:Mycobacterium chelonae / Q000187:drug effects* / Q000235:genetics*; D020102:Mycobacterium smegmatis / Q000187:drug effects* / Q000235:genetics*; D018272:Porins / Q000235:genetics / Q000502:physiology*; D009764:o-Phthalaldehyde / Q000494:pharmacology
D000995:Antitubercular Agents; D004202:Disinfectants; D018272:Porins; D009764:o-Phthalaldehyde; D005976:Glutaral