Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients.
OBJECTIVE
The appropriate management of low-grade gliomas is still a matter of debate. So far, there are no randomized studies that analyze the impact of surgical resection on patient outcome. The value of the data obtained from the few retrospective reports available is often limited.


METHODS
In the present study, we performed an analysis on data of 130 adult low-grade glioma patients. Extent of the resection was evaluated in correlation to the overall survival (OS) and progression-free survival (PFS) using Cox regression multivariate analysis.


RESULTS
Extended surgery was shown to prolong OS and PFS significantly. Re-surgery in the case of a tumor relapse has a significant impact on OS and PFS, too.


CONCLUSIONS
In summary, we could retrospectively evaluate a large case series of well-defined low-grade gliomas patients with a long follow-up period showing that extended surgery would be the most effective therapy for low-grade glioma patients even in recurrent diseases.
Ahmadi
Rezvan
R
Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany. rezvan_ahmadi@med.uni-heidelberg.de
Rezvan
Ahmadi
A
Dictus
Christine
C
Christine
Dictus
D
Hartmann
Christian
C
Christian
Hartmann
H
Zürn
Olga
O
Olga
Zürn
Z
Edler
Lutz
L
Lutz
Edler
E
Hartmann
Marius
M
Marius
Hartmann
H
Combs
Stephanie
S
Stephanie
Combs
C
Herold-Mende
Christel
C
Christel
Herold-Mende
HM
Wirtz
Christian Rainer
CR
Rainer
Wirtz Christian
WC
Unterberg
Andreas
A
Andreas
Unterberg
U
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy / Q000379:methods / Q000706:statistics & numerical data; D004358:Drug Therapy / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D005910:Glioma / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009361:Neoplasm Invasiveness / Q000503:physiopathology / Q000517:prevention & control; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000517:prevention & control / Q000601:surgery; D038361:Neuronavigation; D019635:Neurosurgical Procedures / Q000379:methods* / Q000706:statistics & numerical data*; D011300:Preoperative Care; D011379:Prognosis; D011878:Radiotherapy / Q000379:methods / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013238:Stereotaxic Techniques; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult