Isolation and structural elucidation of dapoxetine as an adulterant in a health supplement used for sexual performance enhancement.
A health supplement used for sexual performance enhancement was sent to Health Sciences Authority of Singapore for testing. An unknown compound was detected and isolated and its structure was elucidated using NMR, high-resolution MS, ESI-MS/MS, UV and IR. The compound, dapoxetine, is reported to be a selective serotonin reuptake inhibitor under investigation for the treatment of premature ejaculation.
Li
Lin
L
Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.
Low
Min-Yong
MY
Ge
Xiaowei
X
Bloodworth
Bosco C
BC
Koh
Hwee-Ling
HL
D001596:Benzylamines / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019587:Dietary Supplements; D004340:Drug Contamination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D009281:Naphthalenes / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013055:Spectrophotometry, Infrared / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods; D013696:Temperature
D001596:Benzylamines; D009281:Naphthalenes; D017367:Selective Serotonin Reuptake Inhibitors; C080598:dapoxetine