Mathematical modeling in metal metabolism: overview and perspectives.
A review of mathematical modeling in metal metabolism is presented. Both endogenous and exogenous metals are considered. Four classes of methods are considered: Petri nets, multi-agent systems, determinist models based on differential equations and stochastic models. For each, a basic theoretical background is given, then examples of applications are given, detailed and commented. Advantages and disadvantages of each class of model are presented. A special attention is given to determinist differential equation models, since almost all models belong to this class.
Curis
Emmanuel
E
Laboratoire de biomathématiques, E. A. 2498 & Plateau iB2, Département Santé publique et biostatistiques, faculté de Pharmacie, Université Paris Descartes, Paris 75006, France. emmanuel.curis@univ-paris5.fr
Nicolis
Ioannis
I
Bensaci
Jalil
J
Deschamps
Patrick
P
Bénazeth
Simone
S
D000818:Animals; D006801:Humans; D008670:Metals / Q000378:metabolism*; D008962:Models, Theoretical
D008670:Metals