title: Impact of elevated pulmonary blood flow and capillary pressure on lung responsiveness.
abstract: Since alterations in pulmonary hemodynamics may lead to airway hyperreactivity, the consequences of individual changes in pulmonary blood flow (Qp) and capillary pressure (Pc) on lung responsiveness were investigated. During maintenance of a steady-state Pc of 5, 10, or 15 mmHg (groups 1-3), acute increases of Qp were generated in isolated, perfused rat lungs by simultaneous pulmonary arterial pressure elevation and venous pressure lowering. Conversely, at constant low (groups 4 and 5) or high Qp (groups 6 and 7), Pc was lowered or elevated by changing, in parallel, the pulmonary arterial and venous pressures. Pulmonary input impedance was measured under baseline conditions and during methacholine provocation (2-18 microg*kg(-1)*min(-1)), whereas the pulmonary hemodynamics were altered in accordance with the group allocation. The airway resistance and constant-phase parenchymal model parameters were identified from the pulmonary input impedance spectra. Increases of Qp at constant Pc had no effect on the basal lung mechanics, whereas they enhanced the lung reactivity to methacholine, particularly when high Pc was maintained [peak airway resistance increases of 299 +/- 99% (SE) vs. 609 +/- 217% at Qp levels of 5 and 10 ml/min, respectively, P < 0.05]. In contrast, the change of Pc at constant Qp slightly deteriorated the basal parenchymal mechanics without affecting the lung responsiveness. These findings suggest that increases in Qp per se may lead to the development of airway hyperreactivity. This phenomenon may contribute to the airway susceptibility under conditions associated with simultaneous elevations in pulmonary vascular pressures and Qp, such as exercise-induced asthma and the situation in children with congenital heart diseases.
authors: Department of Medical Informatics and Engineering, University of Szeged, H-6720 Szeged, Hungary. Petak@dmi.szote.u-szeged.hu
authors: Ferenc
authors: F
authors: Peták
authors: Tibor Z
authors: TZ
authors: Janosi
authors: Carole
authors: C
authors: Myers
authors: Fabienne
authors: F
authors: Fontao
authors: Walid
authors: W
authors: Habre
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001980:Bronchi / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D066298:In Vitro Techniques; D008168:Lung / Q000502:physiology*; D008297:Male; D016210:Methacholine Chloride; D009929:Organ Size / Q000502:physiology; D010277:Parasympathomimetics; D011175:Positive-Pressure Respiration; D011652:Pulmonary Circulation / Q000502:physiology*; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D010277:Parasympathomimetics; D016210:Methacholine Chloride