Potential markers of preeclampsia--a review.
Preeclampsia is a leading cause of maternal and fetal/neonatal mortality and morbidity worldwide. The early identification of patients with an increased risk for preeclampsia is therefore one of the most important goals in obstetrics. The availability of highly sensitive and specific physiologic and biochemical markers would allow not only the detection of patients at risk but also permit a close surveillance, an exact diagnosis, timely intervention (e.g. lung maturation), as well as simplified recruitment for future studies looking at therapeutic medications and additional prospective markers. Today, several markers may offer the potential to be used, most likely in a combinatory analysis, as predictors or diagnostic tools. We present here the current knowledge on the biology of preeclampsia and review several biochemical markers which may be used to monitor preeclampsia in a future, that, we hope, is not to distant from today.
Grill
Simon
S
Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Biomedicine, University Hospital of Basel, Basel, Switzerland. sgrill@uhbs.ch
Rusterholz
Corinne
C
Zanetti-Dällenbach
Rosanna
R
Tercanli
Sevgi
S
Holzgreve
Wolfgang
W
Hahn
Sinuhe
S
Lapaire
Olav
O
D051722:ADAM Proteins / Q000032:analysis; D000072199:ADAM12 Protein; D053607:Adrenomedullin / Q000032:analysis; D043925:Angiogenesis Inducing Agents / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D001158:Arteries / Q000000981:diagnostic imaging; D001323:Autoantibodies / Q000032:analysis; D015415:Biomarkers / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000032:analysis; D004247:DNA / Q000032:analysis; D000071063:Endoglin; D005260:Female; D005333:Fetus / Q000737:chemistry; D037161:Galectins / Q000032:analysis; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis; D054409:Nicotinamide Phosphoribosyltransferase / Q000032:analysis; D019007:P-Selectin / Q000032:analysis; D010920:Placenta / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000503:physiopathology; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D011296:Prenatal Diagnosis; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology; D011956:Receptors, Cell Surface / Q000032:analysis; D000683:Serum Amyloid P-Component / Q000032:analysis; D018608:Ultrasonography, Doppler; D014599:Uterus / Q000098:blood supply / Q000000981:diagnostic imaging; D000099153:Pentraxins
D051722:ADAM Proteins; D000072199:ADAM12 Protein; D053607:Adrenomedullin; D043925:Angiogenesis Inducing Agents; D015703:Antigens, CD; D001323:Autoantibodies; D015415:Biomarkers; D002097:C-Reactive Protein; D016207:Cytokines; D004247:DNA; D000071063:Endoglin; D037161:Galectins; D008565:Membrane Proteins; D054409:Nicotinamide Phosphoribosyltransferase; D019007:P-Selectin; D011257:Pregnancy Proteins; D011266:Pregnancy-Associated Plasma Protein-A; D044140:Receptor, Angiotensin, Type 1; D011956:Receptors, Cell Surface; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C064206:ENG protein, human; C038195:LGALS13 protein, human; C085455:nicotinamide phosphoribosyltransferase, human; C000606480:ADAM12 protein, human