NF-kappaB Activation by compounds found in Platycodon grandiflorum extract.
Compounds extracted from Platycodon grandiflorum were evaluated for an activation effect on nuclear factor-kappa B (NF-kappaB). In its active state, NF-kappaB turns on the expression of genes related to cell proliferation or death. NF-kappaB activators promote growth of neuron cells and can be used to control neurodegenerative diseases. The biological activity of P. grandiflorum extracts toward NF-kappaB had not yet been studied. Although the biological activity of several compounds extracted from P. grandiflorum was evaluated, only three exhibited any significant activation effect on NF-kappaB.
Hong
Sungwon
S
Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul 143-701, Korea.
Yong
Yeonjoong
Y
Kang
Kyungrai
K
Shin
Soon Young
SY
Lee
Young Han
YH
Lim
Yoongho
Y
D002460:Cell Line; D015870:Gene Expression / Q000187:drug effects; D017930:Genes, Reporter / Q000187:drug effects; D006801:Humans; D016328:NF-kappa B / Q000096:biosynthesis* / Q000235:genetics; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D031238:Platycodon; D053279:Polyynes / Q000302:isolation & purification / Q000494:pharmacology; D015533:Transcriptional Activation / Q000187:drug effects*
D016328:NF-kappa B; D010936:Plant Extracts; C521561:lobetyolin; D053279:Polyynes