title: Carotenoids with anti-Helicobacter pylori activity from Golden delicious apple.
abstract: Previously it was reported that hypophasic carotenoids of Golden delicious apple peel showed potent anti-H. pylori activity (MIC(50) = 36 microg/mL), comparable to metronidazole (MIC(50) = 45 microg/mL). To further investigate the involved active carotenoids of the apple peel extracts, seven carotenoids were isolated for the current study: (all-E)-luteoxanthin, (all-E)-neoxanthin, (9'Z)-neoxanthin, (all-E)-antheraxanthin, (all-E)-violaxanthin, (9Z)-violaxanthin and (all-E)-lutein. The MIC(50) values of (all-E)-luteoxanthin, (all-E)-neoxanthin and (9'Z)-neoxanthin were 7.9, 11 and 27 microg/mL, respectively. Other carotenoids and beta,beta-carotene did not exhibit potent anti-H. pylori activity (MIC(50) > 100 microg/mL). An examination of structure and function suggested that active carotenoids contained a monofuranoid ring or an allenic bond in addition to an epoxy group and an additional two or three hydroxyl substituents on the side group.
authors: Department of Pharmacognosy, University of Pécs Medical School, Pécs, Hungary.
authors: Péter
authors: P
authors: Molnár
authors: József
authors: J
authors: Deli
authors: Toru
authors: T
authors: Tanaka
authors: Yoshiyuki
authors: Y
authors: Kann
authors: Satoru
authors: S
authors: Tani
authors: Nóra
authors: N
authors: Gyémánt
authors: Joseph
authors: J
authors: Molnár
authors: Masami
authors: M
authors: Kawase
mesh_terms: D002851:Chromatography, High Pressure Liquid; D016480:Helicobacter pylori / Q000187:drug effects*; D027845:Malus / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D024341:Xanthophylls / Q000494:pharmacology*
chemical_list: D024341:Xanthophylls