Cutaneous mast cell tumour within a lipoma in a boxer.
This report describes a case of a canine cutaneous grade I mast cell tumour which developed within a lipoma in the right axillar region of an 8-year-old male Boxer. Immunohistologically, the neoplastic mast cells were positive for serotonin, CD45 vimentin and p53, and negative for lysozyme, CD3 and CD79a expression. The proliferation index of the mast cell tumour based on the Ki-67 antigen was 6.1%. Between the benign neoplastic lipocytes and mastocytoma tumour cells intratumoural microvessels were detected by immunohistochemical staining using CD31 and claudin-5 as markers for vascular endothelium.
Jakab
Csaba
C
Szent István University, Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Medicine, István utca 2 H-1078 Budapest, Hungary. Jakab.Csaba@aotk.szie.hu
Szász
Attila Marcell
AM
Kulka
Janina
J
Schaff
Zsuzsa
Z
Rusvai
Miklós
M
Németh
Tibor
T
Gálfi
Péter
P
D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D007150:Immunohistochemistry; D008067:Lipoma / Q000473:pathology / Q000662:veterinary*; D008297:Male; D034801:Mastocytoma / Q000473:pathology / Q000662:veterinary*; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*