title: Calorie restriction alters mitochondrial protein acetylation.
abstract: Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown. Here we show that lysine acetylation of mitochondrial proteins is altered during CR in a tissue-specific fashion. Via large-scale mass spectrometry screening, we identify 72 candidate proteins involved in a variety of metabolic pathways with altered acetylation during CR. Mitochondrial acetylation changes may play an important role in the pro-longevity CR response.
authors: Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute, The Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
authors: Bjoern
authors: B
authors: Schwer
authors: Mark
authors: M
authors: Eckersdorff
authors: Yu
authors: Y
authors: Li
authors: Jeffrey C
authors: JC
authors: Silva
authors: Damian
authors: D
authors: Fermin
authors: Martin V
authors: MV
authors: Kurtev
authors: Cosmas
authors: C
authors: Giallourakis
authors: Michael J
authors: MJ
authors: Comb
authors: Frederick W
authors: FW
authors: Alt
authors: David B
authors: DB
authors: Lombard
mesh_terms: D000107:Acetylation; D000818:Animals; D031204:Caloric Restriction / Q000706:statistics & numerical data*; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000502:physiology*; D008322:Mammals / Q000254:growth & development / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D004718:Saccharomycetales / Q000254:growth & development / Q000502:physiology*
chemical_list: D011506:Proteins