Chronic use of the immunomodulating tripeptide feG-COOH in experimental feline asthma.
We have previously documented that a single dose of feG-COOH prior to allergen challenge significantly decreased eosinophilic airway inflammation in cats with experimental asthma, but did not result in complete resolution of airway inflammation. This study was undertaken to determine if a chronic (2 weeks) course of feG-COOH in experimentally asthmatic cats would induce complete remission of airway inflammation and clinical signs of asthma. Experimental asthma was induced using Bermuda grass allergen (BGA) and cats were randomly selected to receive either feG-COOH (1mg/kg, PO) or saline for 2 weeks, followed by a 2-week washout period. Cats then received the alternate treatment. Aerosol challenge with BGA was performed weekly throughout the study and bronchoalveolar lavage fluid (BALF) and blood were collected prior to and after each of the 2-week treatment periods. Regular use of feG-COOH had no significant effect on airway inflammation, BALF and plasma TNF bioactivity or a clinical sign compared to placebo. Regular use of feG-COOH can thus not be recommended as the sole therapy for feline allergic asthma.
Eberhardt
Jason M
JM
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 East Campus Drive, Columbia, MO 65211, USA.
DeClue
Amy E
AE
Reinero
Carol R
CR
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D052179:Antigens, Plant / Q000008:administration & dosage; D001249:Asthma / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology / Q000662:veterinary*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D002371:Cat Diseases / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D002415:Cats; D031744:Cynodon / Q000009:adverse effects / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004804:Eosinophils / Q000187:drug effects / Q000276:immunology; D005260:Female; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*
D018927:Anti-Asthmatic Agents; D052179:Antigens, Plant; D016207:Cytokines; D007155:Immunologic Factors; D009842:Oligopeptides; C114891:tripeptide FEG