title: Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys.
abstract: Functional magnetic resonance imaging (fMRI) is a powerful tool for examining kidney function, including organ blood flow and oxygen bioavailability. We have used contrast enhanced perfusion and blood oxygen level-dependent (BOLD) MRI to assess kidney transplants with normal function, acute tubular necrosis (ATN) and acute rejection. BOLD and MR-perfusion imaging were performed on 17 subjects with recently transplanted kidneys. There was a significant difference between medullary R2 values in the group with acute rejection (R2=16.2/s) compared to allografts with ATN (R2=19.8/s; P=.047) and normal-functioning allografts (R2=24.3/s;P=.0003). There was a significant difference between medullary perfusion measurements in the group with acute rejection (124.4+/-41.1 ml/100 g per minute) compared to those in patients with ATN (246.9+/-123.5 ml/100 g per minute; P=.02) and normal-functioning allografts (220.8+/-95.8 ml/100 g per minute; P=.02). This study highlights the utility of combining perfusion and BOLD MRI to assess renal function. We have demonstrated a decrease in medullary R2 (decrease deoxyhemoglobin) on BOLD MRI and a decrease in medullary blood flow by MR perfusion imaging in those allografts with acute rejection, which indicates an increase in medullary oxygen bioavailability in allografts with rejection, despite a decrease in blood flow.
authors: Department of Radiology, University of Wisconsin, Madison, WI 53792, USA. esadowski@uwhealth.org
authors: Elizabeth A
authors: EA
authors: Sadowski
authors: Arjang
authors: A
authors: Djamali
authors: Andrew L
authors: AL
authors: Wentland
authors: Rebecca
authors: R
authors: Muehrer
authors: Bryan N
authors: BN
authors: Becker
authors: Thomas M
authors: TM
authors: Grist
authors: Sean B
authors: SB
authors: Fain
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D005260:Female; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology*; D016030:Kidney Transplantation; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D010100:Oxygen