Sensitive and efficient detection of thrombus with fibrin-specific manganese nanocolloids.
In this work, we report novel fibrin targeted "soft-type" manganese-based contrast agents for MRI with the potential to noninvasively image intravascular thrombus which could warrant aggressive medical intervention to preclude subsequent myocardial infarction or stroke.
Pan
Dipanjan
D
Division of Cardiology and C-TRAIN, Washington University School of Medicine, St. Louis, MO 63108, USA. dipanjan@wustl.edu
Senpan
Angana
A
Caruthers
Shelton D
SD
Williams
Todd A
TA
Scott
Mike J
MJ
Gaffney
Patrick J
PJ
Wickline
Samuel A
SA
Lanza
Gregory M
GM
D003102:Colloids; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry* / Q000378:metabolism*; D017895:Manganese Compounds / Q000737:chemistry / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry / Q000378:metabolism; D010087:Oxides / Q000737:chemistry / Q000378:metabolism; D012680:Sensitivity and Specificity; D013379:Substrate Specificity; D013927:Thrombosis / Q000175:diagnosis*
D003102:Colloids; D003287:Contrast Media; D017895:Manganese Compounds; D010087:Oxides; D019301:Oleic Acid; D008345:Manganese; C027424:manganese oxide; D005337:Fibrin