title: Discovery of swine as a host for the Reston ebolavirus.
abstract: Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.
authors: Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, Animal and Plant Health Inspection Services, United States Department of Agriculture, Plum Island Animal Disease Center, New York, NY 11944, USA.
authors: Roger W
authors: RW
authors: Barrette
authors: Samia A
authors: SA
authors: Metwally
authors: Jessica M
authors: JM
authors: Rowland
authors: Lizhe
authors: L
authors: Xu
authors: Sherif R
authors: SR
authors: Zaki
authors: Stuart T
authors: ST
authors: Nichol
authors: Pierre E
authors: PE
authors: Rollin
authors: Jonathan S
authors: JS
authors: Towner
authors: Wun-Ju
authors: WJ
authors: Shieh
authors: Brigid
authors: B
authors: Batten
authors: Tara K
authors: TK
authors: Sealy
authors: Consuelo
authors: C
authors: Carrillo
authors: Karen E
authors: KE
authors: Moran
authors: Alexa J
authors: AJ
authors: Bracht
authors: Gregory A
authors: GA
authors: Mayr
authors: Magdalena
authors: M
authors: Sirios-Cruz
authors: Davinio P
authors: DP
authors: Catbagan
authors: Elizabeth A
authors: EA
authors: Lautner
authors: Thomas G
authors: TG
authors: Ksiazek
authors: William R
authors: WR
authors: White
authors: Michael T
authors: MT
authors: McIntosh
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004196:Disease Outbreaks / Q000662:veterinary; D004197:Disease Reservoirs; D029043:Ebolavirus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D018702:Filoviridae Infections / Q000150:complications / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D010679:Philippines / Q000453:epidemiology; D010802:Phylogeny; D019318:Porcine Reproductive and Respiratory Syndrome / Q000453:epidemiology / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D034421:Sus scrofa; D013553:Swine Diseases / Q000453:epidemiology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral