Antimicrobial peptides and viral fusion peptides: how different they are?
Similarly to antimicrobial peptides (AMPs), viral fusion peptides (FPs) are membrane-active peptides. This minireview emphasizes the common properties of AMPs and FPs with a special focus on the intrinsic flexibility and structural adaptability of these peptides that are responsible for different mode of interaction with the membrane bilayers. The potential use of AMPs as multifunctional drugs with both antibacterial and antiviral properties is discussed.
Joanne
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FRE 2852 Protéines: Biochimie Structurale et Fonctionnelle, Université Paris 6-CNRS, Peptidome de la peau d'amphibiens, tour 43, 4, Place Jussieu 75252 Paris cedex 05, France.
Nicolas
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El Amri
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D000595:Amino Acid Sequence; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D055598:Chemical Phenomena; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D014760:Viral Fusion Proteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D053586:Virus Internalization / Q000187:drug effects
D023181:Antimicrobial Cationic Peptides; D010455:Peptides; D014760:Viral Fusion Proteins