[Incidence and influential factors of post-operative nausea and vomiting following gynecological surgery: analysis of 492 cases].
OBJECTIVE
To investigate the incidence and influential factors of post-operative nausea and vomiting (PONV) following gynecologic surgery so as to provide guideline effective for clinical management.


METHODS
The clinical data of 492 qualified consecutive female patients who had undergone gynecological surgery were analyzed. Univariate analysis and multivariate logistic regression were applied to examine the relations between the perioperative variables and occurrence of PONV within 6 h or 24 h following gynecologic procedures.


RESULTS
PONV developed in 218 patients within 24 h following surgery (44.3%) while in 161 patients within 6 h following surgery (32.7%). Multivariate logistic regression analysis identified PONV history and perioperative opioids administration as significant predictors of PONV within 24 h following gynecologic surgery, while PONV history, general anesthesia, and postoperative shivering predictors of PONV within 6 h after surgery, and found the administration of dexamethasone or droperidol as consistent protective factors of PONV within 6 h or 24 h following surgery.


CONCLUSIONS
For gynecologic surgery, previous PONV history will increase the risk for PONV following current surgery. Perioperative opioids administration will intensify the risk for the development of PONV within 24 h following surgery, while general anesthesia and postoperative shivering for PONV within 6 h after surgery. Perioperative dexamethasone or droperidol will decrease the incidence of PONV within 6 h or 24 h following gynecologic procedures.
Zhang
Hong
H
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China.
Wu
Xin-min
XM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology* / Q000517:prevention & control*; D012307:Risk Factors; D055815:Young Adult