title: Haemophilus parainfluenzae meningitis in an adult associated with acute otitis media.
abstract: A case of Haemophilus parainfluenzae meningitis in a woman with a 3-day history of acute otitis media is reported. Her medical history included bladder cancer surgery. Unequivocal identification of the isolate was obtained by using molecular techniques such as 16S rRNA sequencing besides to conventional culture methods. To investigate bacterial virulent traits possibly related to invasive properties, in vitro serum resistance of our isolate was analyzed, but it was found serum susceptible. Our study demonstrates that H. parainfluenzae can be considered an opportunistic pathogen able to cause life-threatening infections not only in children but also in patients with underlying conditions.
authors: Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
authors: Rita
authors: R
authors: Cardines
authors: Maria
authors: M
authors: Giufrè
authors: Marta Luisa
authors: ML
authors: Ciofi degli Atti
authors: Marisa
authors: M
authors: Accogli
authors: Paola
authors: P
authors: Mastrantonio
authors: Marina
authors: M
authors: Cerquetti
mesh_terms: D000208:Acute Disease; D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002443:Ceftriaxone / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D007262:Infusions, Intravenous; D008583:Meningitis, Haemophilus / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D010033:Otitis Media / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D012329:RNA, Bacterial / Q000032:analysis / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000032:analysis / Q000235:genetics; D014774:Virulence
chemical_list: D000900:Anti-Bacterial Agents; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S; D002443:Ceftriaxone; D000667:Ampicillin