Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol.
Sreeramulu
Sridhar
S
Johann Wolfgang Goethe-University, Frankfurt am Main, Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
Gande
Santosh Lakshmi
SL
Göbel
Michael
M
Schwalbe
Harald
H
D001665:Binding Sites; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018833:Chaperonins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D053978:Pentacyclic Triterpenes; D017510:Protein Folding; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
C498362:CDC37 protein, human; D018797:Cell Cycle Proteins; D018841:HSP90 Heat-Shock Proteins; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D018833:Chaperonins; C050414:celastrol