title: Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis.
abstract: Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection.
authors: Iowa State University, Department of Biochemistry, Biophysics, and Molecular Biology, Ames, Iowa 5001, USA.
authors: Francis M
authors: FM
authors: Mann
authors: Meimei
authors: M
authors: Xu
authors: Xiaoming
authors: X
authors: Chen
authors: D Bruce
authors: DB
authors: Fulton
authors: David G
authors: DG
authors: Russell
authors: Reuben J
authors: RJ
authors: Peters
mesh_terms: D003500:Cyclization; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D007700:Kinetics; D009169:Mycobacterium tuberculosis / Q000737:chemistry*; D010588:Phagosomes / Q000187:drug effects / Q000378:metabolism
chemical_list: D004224:Diterpenes; C547162:edaxadiene