Supression of nociceptive responses in the rat by physostigmine. Role of serotonin.
Physostigmine produced a dose-related suppression of nociceptive response in the rat, as tested by the rat tail-hot wire technique. The antinociceptive action of physostigmine was significantly reduced after treatment with drugs known to reduce brain serotonin activity. The results suggest that the antinociceptive action of physostigmine, in the rat, is serotonin-mediated.
Bhattacharya
S K
SK
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Nayak
B B
BB