title: Daily glucose profiles in Japanese people with normal glucose tolerance as assessed by continuous glucose monitoring.
abstract: BACKGROUND
  Little information is available regarding glucose fluctuations in postprandial states and during the oral glucose tolerance test (OGTT) in Japanese people with normal glucose tolerance (NGT).
  
  
  METHODS
  Glucose profiles of 27 Japanese people were measured for 4 days by using continuous glucose monitoring. A 75-g OGTT was conducted on the second day, and 24 subjects diagnosed with NGT by a 75-g OGTT were enrolled. The subjects were monitored for their postprandial glucose profile in their ordinary daily life on the third day.
  
  
  RESULTS
  The results of our study have shown that the median time (interquartile range) to maximum glucose levels in OGTT was 38 (25-49) min after glucose load and that the median time to maximum glucose levels after breakfast, lunch, and dinner was 40 (31-75), 50 (30-70), and 45 (36-50) min, respectively. The median increase in glucose during OGTT was 45 (35-66) mg/dL, and that after breakfast, lunch and dinner was 21 (12-32), 37 (27-48), and 44 (25-63) mg/dL, respectively. Those with a higher insulinogenic index reached their maximum glucose levels in a shorter time (r = -0.46, P = 0.025) and had smaller glucose increments during OGTT (r = -0.49, P = 0.014).
  
  
  CONCLUSIONS
  This study is the first report to document the glucose profile of Asian people with NGT.
authors: Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. ms97-tsujino@jikei.ac.jp
authors: Daisuke
authors: D
authors: Tsujino
authors: Rimei
authors: R
authors: Nishimura
authors: Kentaro
authors: K
authors: Taki
authors: Yumi
authors: Y
authors: Miyashita
authors: Aya
authors: A
authors: Morimoto
authors: Naoko
authors: N
authors: Tajima
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D004435:Eating; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007564:Japan; D007700:Kinetics; D008297:Male; D008505:Medical Staff, Hospital; D008991:Monitoring, Physiologic / Q000379:methods*; D009741:Nursing Staff, Hospital; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin