title: In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods.
abstract: The use of gold nanorods for photoacoustic molecular imaging with simultaneous multiple targeting is reported. Multiple targeting is done by utilizing the tunable optical absorption property of gold nanorods. This technique allows multiple molecular signatures to be obtained by simply switching laser wavelength. HER2 and EGFR were chosen as the primary target molecules for examining two cancer cells, OECM1 and Cal27. Both in vitro and in vivo mouse model imaging experiments were performed, with contrast enhancement of up to 10 dB and 3.5 dB, respectively. The potential in improving cancer diagnosis is demonstrated.
authors: Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan. paichi@cc.ee.ntu.edu.tw
authors: Pai-Chi
authors: PC
authors: Li
authors: Churng-Ren Chris
authors: CR
authors: Wang
authors: Dar-Bin
authors: DB
authors: Shieh
authors: Chen-Wei
authors: CW
authors: Wei
authors: Chao-Kang
authors: CK
authors: Liao
authors: Carolina
authors: C
authors: Poe
authors: Suwen
authors: S
authors: Jhan
authors: Ann-Ann
authors: AA
authors: Ding
authors: Ya-Na
authors: YN
authors: Wu
mesh_terms: D000818:Animals; D000906:Antibodies; D017076:Computer-Aided Design; D016503:Drug Delivery Systems / Q000379:methods; D054459:Elasticity Imaging Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D066246:ErbB Receptors / Q000378:metabolism*; D006046:Gold; D006801:Humans; D008297:Male; D051379:Mice; D016513:Mice, SCID; D015336:Molecular Probe Techniques / Q000295:instrumentation*; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology*; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018511:Systems Integration
chemical_list: D000906:Antibodies; D006046:Gold; D066246:ErbB Receptors