title: [Estimated half-life of penta-chlorodibenzofuran (PeCDF) and simulation of PeCDF excretion].
abstract: The half-life of 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in the Yusho patients has been reported to be approximately seven years. In the present study, we estimated the half-life of PeCDF using data from the medical check-ups of more than 300 Yusho patients. We performed linear regression analysis with a binary logarithm of PeCDF blood level in Yusho patients as the dependent variable, and the measurement year as the independent variable. Our results showed that there were many patients who had shown no reduction of their blood PeCDF level for several years. This result contradicts the previously reported half-life period. Therefore, we believe that a more complicated excretion model needs to be established to explain the discrepancy we found. We hypothesized that there might be two mechanisms of PeCDF assimilation in human digestive tract. In the present study, we also used our hypothesis to simulate PeCDF excretion in Yusho patients.
authors: Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine, Japan. makahane@naramed-u.ac.jp
authors: Manabu
authors: M
authors: Akahane
authors: Shinya
authors: S
authors: Matsumoto
authors: Yoshiyuki
authors: Y
authors: Kanagawa
authors: Jumboku
authors: J
authors: Kajiwara
authors: Takashi
authors: T
authors: Todaka
authors: Hironori
authors: H
authors: Hirakawa
authors: Soichi
authors: S
authors: Koike
authors: Masutaka
authors: M
authors: Furue
authors: Tomoaki
authors: T
authors: Imamura
mesh_terms: D001572:Benzofurans / Q000097:blood / Q000378:metabolism*; D004147:Dioxins / Q000378:metabolism* / Q000506:poisoning*; D005506:Food Contamination; D006207:Half-Life; D006801:Humans; D008962:Models, Theoretical; D011078:Polychlorinated Biphenyls / Q000506:poisoning*
chemical_list: D001572:Benzofurans; D004147:Dioxins; D011078:Polychlorinated Biphenyls; C038890:2,3,4,7,8-pentachlorodibenzofuran