[Experimental model of anxiety-depression state in rats exposed to inhibitor of dipeptidyl peptidase IV methionyl-2(S)-cyano-pyrrolidine in early postnatal period].
The effects of irreversible synthetic inhibitor of dipeptidyl peptidase IV (DPPIV) methionyl-2(S)-cyano-pyrrolidine on behavior of adolescent and adult rats were studied. The inhibitor was administered in early postnatal period from day 5 to day 19 (1 mg/kg, i.p.) in rat pups (males and females). In 1-2-month-old males treated with inhibitor of DPPIV, increased anxiety was revealed in the elevated plus maze and in the open field, 2- and 7-month-old males demonstrated the increased anxiety in a special battery of tests for evaluating anxiety-phobic states, whereas in female 1-3 months-old rats, the increased anxiety was observed in the elevated plus-maze. The depression-like behavior in the forced swimming test was revealed in 2-3 month-old males and in 2- and 7-month-old females. Adolescent and adult (1-2-month-old) rats of both genders and 7-month-old females demonstrated anhedonia in sucrose consumption/preference test. The findings prove the development of anxiety-depression-like state in rats postnatally exposed to inhibitor of DPPIV and suggest the DPPIV involvement in the development of anxiety and depression.
Krupina
N A
NA
Kushnareva
E Iu
EIu
Khlebnikova
N N
NN
Zolotov
N N
NN
Kryzhanovskiĭ
G N
GN
D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000523:psychology; D003863:Depression / Q000139:chemically induced* / Q000523:psychology; D054873:Dipeptidyl-Peptidase IV Inhibitors; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008715:Methionine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011759:Pyrrolidines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D054873:Dipeptidyl-Peptidase IV Inhibitors; D011759:Pyrrolidines; C542626:methionyl-2-cyanopyrrolidine; D008715:Methionine