Association between -455G/A and fibrinogen in a Chinese population.
OBJECTIVE
The aim of the study was to evaluate the association between beta-fibrinogen gene -455G/A polymorphism and the plasma fibrinogen level in Chinese patients with different subtypes of coronary heart disease (CHD).


RESULTS
We investigated beta-fibrinogen gene -455G/A polymorphism and plasma fibrinogen level in non-CHD control subjects (n = 466) and CHD patients (n = 1,019) including patients with stable angina pectoris (SAP) (n = 674), and acute coronary syndrome (ACS) (n = 345). Increased plasma fibrinogen levels were observed in the CHD groups compared with the control subjects (ACS: 380.92 +/- 92.35 mg/dl, SAP: 352.49 +/- 94.89 mg/dl, control: 311.72 +/- 87.09* mg/dl, *P < 0.001 vs. ACS and SAP). Individuals with the -455A/A genotype were associated with the highest plasma fibrinogen in the control subjects (P < 0.001) and patients with SAP (P < 0.001) but not in patients with ACS (P > 0.05). Allele frequency and genotype distribution were similar among the three groups (P = 0.314).


CONCLUSIONS
This study demonstrated that elevated plasma fibrinogen level is related to increased CHD risk. The presence of -455A allele is significantly associated with higher fibrinogen in non-CHD control subjects and SAP patients but not in ACS patients while -455G/A polymorphism is not a risk factor for CHD in the Chinese population.
Sun
Aijun
A
Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Ma
Huili
H
Xu
Danling
D
Wang
Ying
Y
Liu
Ming
M
Xu
Lei
L
Chen
Jilin
J
Hu
Taohong
T
Wang
Zhen
Z
Wang
Keqiang
K
Zou
Yunzeng
Y
Huang
Wei
W
Ge
Junbo
J
D054058:Acute Coronary Syndrome / Q000097:blood / Q000235:genetics; D000483:Alleles; D000787:Angina Pectoris / Q000097:blood / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000235:genetics* / Q000378:metabolism; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D013223:Statistics as Topic
D005340:Fibrinogen