title: Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis.
abstract: OBJECTIVE
  Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular permeability. The VEGF gene is polymorphic. We investigated the prognostic significance of three VEGF single nucleotide polymorphisms (SNP) in esophageal cancer.
  
  
  METHODS
  Three hundred sixty-one patients were genotyped for three VEGF SNPs (-460T/C, 405G/C, and 936C/T) using DNA extracted from prospectively collected blood samples. The association of each individual SNP, and haplotypes of the three SNPs, on overall survival (OS) was investigated.
  
  
  RESULTS
  The variant allele of 936C/T was associated with improved OS compared with the wild-type genotype (log-rank P < 0.001). This association remained significant for OS after adjustments for age, gender, performance status, and disease stage [VEGF 936C/T: adjusted hazard ratio (AHR), 0.70; 95% confidence interval (95% CI), 0.49-0.99; P = 0.04; VEGF 936T/T: AHR, 0.11; 95% CI, 0.02-0.82; P = 0.03]. No independent associations were found for VEGF -460T/C and VEGF 405G/C. The CGC haplotype of the three VEGF SNPs (-460T/C, 405G/C, and 936C/T) combined was associated with reduced OS compared with all other patients (CGC/CGC: AHR, 1.51; 95% CI, 1.00-2.30; P = 0.05).
  
  
  CONCLUSIONS
  VEGF 936C/T, and a haplotype of 460T/C, 405G/C, and 936C/T combined, has potential prognostic significance in esophageal cancer.
authors: Medical Oncology and Haematology, Department of Medicine, Princess Margaret Hospital, Ontario Cancer Institute, University of Toronto,Toronto, Ontario M5G 2M9, Canada.
authors: Penelope A
authors: PA
authors: Bradbury
authors: Rihong
authors: R
authors: Zhai
authors: Clement
authors: C
authors: Ma
authors: Wei
authors: W
authors: Xu
authors: Jessica
authors: J
authors: Hopkins
authors: Matthew J
authors: MJ
authors: Kulke
authors: Kofi
authors: K
authors: Asomaning
authors: Zhaoxi
authors: Z
authors: Wang
authors: Li
authors: L
authors: Su
authors: Rebecca S
authors: RS
authors: Heist
authors: Thomas J
authors: TJ
authors: Lynch
authors: John C
authors: JC
authors: Wain
authors: David
authors: D
authors: Christiani
authors: Geoffrey
authors: G
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004938:Esophageal Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D055815:Young Adult
chemical_list: D042461:Vascular Endothelial Growth Factor A