title: The prevalence of abnormal liver enzymes and metabolic syndrome in obese adolescent females with polycystic ovary syndrome.
abstract: OBJECTIVE
  We sought to determine the prevalence of abnormal liver enzymes suggestive of nonalcoholic steatohepatitis and metabolic syndrome in obese adolescent females with polycystic ovary syndrome.
  
  
  METHODS
  A retrospective chart review.
  
  
  METHODS
  Patients included 39 obese (body mass index Z score >/= 2) adolescent females with a diagnosis of polycystic ovary syndrome. Clinical and biochemical data in these patients were reviewed.
  
  
  METHODS
  Aspartate and alanine aminotransferase levels, lipid panel, blood pressure, body mass index, and glucose intolerance were the main outcome measures of the study.
  
  
  RESULTS
  The study showed that 15.4 % (6 of 39) of patients had elevated aminotransferase levels, suggestive of nonalcoholic steatohepatitis, and 43.6 % (17 of 39) of patients qualified as having metabolic syndrome. Finally, 10.2 % (4 of 39) of patients were found to have both liver dysfunction and metabolic syndrome.
  
  
  CONCLUSIONS
  Liver dysfunction consistent with nonalcoholic steatohepatitis and metabolic syndrome are prevalent in obese adolescent females with polycystic ovary syndrome. Therefore, early screening and further work-up for both disease states are warranted in cases of young adolescent females with polycystic ovary syndrome.
authors: New York University School of Medicine, New York, New York, USA.
authors: Elaine
authors: E
authors: Barfield
authors: Ying-Hua
authors: YH
authors: Liu
authors: Marion
authors: M
authors: Kessler
authors: Melissa
authors: M
authors: Pawelczak
authors: Raphael
authors: R
authors: David
authors: Bina
authors: B
authors: Shah
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001224:Aspartic Acid / Q000097:blood; D002648:Child; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008099:Liver / Q000201:enzymology*; D008111:Liver Function Tests; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000503:physiopathology; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000201:enzymology / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D012189:Retrospective Studies
chemical_list: D001224:Aspartic Acid; D000410:Alanine Transaminase