Role of GTPases in bacterial ribosome assembly.
The assembly of the ribosome, a complex molecular machine composed of RNA and protein, is a poorly understood process. Recent work has demonstrated that GTPases are likely to play key roles in the assembly of ribosomes in bacteria and eukaryotes. This review highlights several bacterial ribosome assembly GTPases (RA-GTPases) and discusses possible functions for these proteins in the biogenesis of individual ribosomal subunits and subunit joining. RA-GTPases appear to link various aspects of the cell cycle and metabolism with translation. How these RA-GTPases may coordinate these connections are discussed.
Britton
Robert A
RA
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA. rbritton@msu.edu
D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000502:physiology*; D008954:Models, Biological; D008958:Models, Molecular; D012335:RNA, Ribosomal / Q000378:metabolism; D054657:Ribosome Subunits / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism*
D001426:Bacterial Proteins; D012335:RNA, Ribosomal; D020558:GTP Phosphohydrolases