title: Combining dissimilarities in a Hyper Reproducing Kernel Hilbert Space for complex human cancer prediction.
abstract: DNA microarrays provide rich profiles that are used in cancer prediction considering the gene expression levels across a collection of related samples. Support Vector Machines (SVM) have been applied to the classification of cancer samples with encouraging results. However, they rely on Euclidean distances that fail to reflect accurately the proximities among sample profiles. Then, non-Euclidean dissimilarities provide additional information that should be considered to reduce the misclassification errors. In this paper, we incorporate in the nu-SVM algorithm a linear combination of non-Euclidean dissimilarities. The weights of the combination are learnt in a (Hyper Reproducing Kernel Hilbert Space) HRKHS using a Semidefinite Programming algorithm. This approach allows us to incorporate a smoothing term that penalizes the complexity of the family of distances and avoids overfitting. The experimental results suggest that the method proposed helps to reduce the misclassification errors in several human cancer problems.
authors: Department of Computer Science, Universidad Pontificia de Salamanca (UPSA), C/Compañía 5, 37002 Salamanca, Spain. mmartinmac@upsa.es
authors: Manuel
authors: M
authors: Martín-Merino
authors: Angela
authors: A
authors: Blanco
authors: Javier
authors: J
authors: De Las Rivas
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D020869:Gene Expression Profiling / Q000379:methods; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D008224:Lymphoma, Follicular / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D015203:Reproducibility of Results