Porcine gelatin microsphere/calcium phosphate cement composites: an in vitro degradation study.
Scaffolds for bone tissue engineering preferably should be mechanically stable, osteoconductive, biodegradable and porous. To comply with these characteristics, calcium phosphate cements (CPCs) with porcine (type A) gelatin microspheres were formulated. In this experiment, in vitro degradation of 10 wt % gelatin type A microsphere CPCs (GELA CPCs) was followed for 12 weeks in proteolytic medium. Results showed a gradual decrease in mass, compression strength and E-modulus. Morphology investigation showed that degradation of the spheres started at the surface of the composite and gradually proceeded to the inner part. Overall, porcine gelatin microspheres can be used to generate in situ macroporosity into an injectable CPC.
Habraken
Wouter J E M
WJEM
Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Wolke
Joop G C
JGC
Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Mikos
Antonios G
AG
Department of Bioengineering, Rice University, Houston, Texas.
Jansen
John A
JA
Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
D020341:Absorbable Implants; D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry*; D006244:Hardness; D007267:Injections; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D010447:Peptide Hydrolases / Q000737:chemistry; D016062:Porosity; D013314:Stress, Mechanical; D013552:Swine; D054457:Tissue Scaffolds / Q000737:chemistry*
D001843:Bone Cements; D002130:Calcium Phosphates; D005780:Gelatin; D010447:Peptide Hydrolases