Palladium-catalyzed amidation-hydrolysis reaction of gem-dihaloolefins: efficient synthesis of homologated carboxamides from ketones.
A simple and efficient palladium-catalyzed amidation-hydrolysis reaction has been developed to afford N-aryl monosubstituted carboxamides in good to excellent yields from easily accessible ketone-derived gem-dihaloolefins and aryl amines.
Ye
Wenchao
W
Department of Chemistry, Shanghai University, Shanghai 200444, China.
Mo
Jun
J
Zhao
Tiankun
T
Xu
Bin
B
D000475:Alkenes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D006868:Hydrolysis; D007659:Ketones / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000475:Alkenes; D000577:Amides; D000588:Amines; D007659:Ketones; D010165:Palladium