title: Association between dopaminergic genes (SLC6A3 and DRD2) and stuttering among Han Chinese.
abstract: Normal function of the dopaminergic system is necessary for speech fluency. There was evidence that the activities of dopamine transporter (DAT) and dopamine D2 receptor (DRD2) could be altered in people with speech disfluency. This study aims to ascertain the possible correlation between two dopaminergic genes (SLC6A3 and DRD2) and disorder of speech fluency, and to determine the allelic frequencies of the five single-nucleotide polymorphisms (SNPs) (rs2617604, rs28364997, rs28364998 in SLC6A3 and rs6275, rs6277 in DRD2) among Han Chinese patients with this disorder. A sample of 112 patients with speech disfluency and 112 gender-matched controls were included in this case-control study. The results show that the presence of C allele at rs6277 in DRD2 gene is associated with increased susceptibility to the disorder, whereas T allele is protective. Haplotype 939T/957T is also a protective factor.
authors: Department of Genetics, College of Life Sciences, Graduate University of Chinese Academy of Sciences, Beijing, PR China.
authors: Jie
authors: J
authors: Lan
authors: Manshu
authors: M
authors: Song
authors: Chunhui
authors: C
authors: Pan
authors: Guoqing
authors: G
authors: Zhuang
authors: Youxin
authors: Y
authors: Wang
authors: Wenzhan
authors: W
authors: Ma
authors: Qiaoyun
authors: Q
authors: Chu
authors: Qingxuan
authors: Q
authors: Lai
authors: Feng
authors: F
authors: Xu
authors: Yanli
authors: Y
authors: Li
authors: Lixin
authors: L
authors: Liu
authors: Wei
authors: W
authors: Wang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D013342:Stuttering / Q000235:genetics*; D055815:Young Adult
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D017448:Receptors, Dopamine D2; C493214:SLC6A3 protein, human