title: Neuroligand binding endophenotypes in blood cells distinguish two subsets of borderline personality disorder patients.
abstract: Neurotransmitter ligand binding in blood cells was assessed in borderline personality disorder (BDP) patients, testing the possibility that different biochemical endophenotypes might lie beneath a specific clinical presentation. The density of peripheral benzodiazepine receptors (PBR) and serotonin transporters were assessed in peripheral blood mononuclear cells (PBMC) and platelets, respectively, showing a decrease of both parameters. Moreover, a further significant decrease of PBR in PBMC was shown for those patients with a depressive trait. Further confirmation of the presence of different molecular endophenotypes underlying the dissimilar clinical presentations in BPD may advance our possibility of successfully treating these patients.
authors: Department of Neuroscience and Biomedical Technologies, University of Milano-Bicocca, Monza, Italy.
authors: Barbara
authors: B
authors: Begni
authors: Lucio
authors: L
authors: Tremolizzo
authors: Simona
authors: S
authors: Andreoni
authors: Margherita
authors: M
authors: Contri
authors: Orlando
authors: O
authors: Uccellini
authors: Francesca
authors: F
authors: Neri
authors: Carlo
authors: C
authors: Ferrarese
mesh_terms: D000293:Adolescent; D001883:Borderline Personality Disorder / Q000097:blood*; D006403:Hematologic Tests / Q000379:methods; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D010641:Phenotype; D011963:Receptors, GABA-A / Q000097:blood*; D012701:Serotonin / Q000097:blood*
chemical_list: D011963:Receptors, GABA-A; D012701:Serotonin