[Mitochondrial genome and longevity].
In humans, mitochondrial DNA (mtDNA) is a 16,569-bp double-stranded circular molecule, encoding 37 genes, and is exclusively transmitted from the mother. According to the recent findings from many studies of mitochondrial diseases caused by nuclear gene mutations, the accumulation of somatic mtDNA mutations in tissues has been expected to contribute toward age-associated mitochondrial dysfunction and a life span.
Nishigaki
Yutaka
Y
Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology (TMIG).
Tanaka
Masashi
M
D000375:Aging / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D008136:Longevity / Q000235:genetics
D004272:DNA, Mitochondrial