title: EBV-positive diffuse large B-cell lymphoma in a human T-lymphotropic virus type 1 carrier.
abstract: The development of B-cell lymphomas has been seldom described in HTLV-1 carriers. We present the case of an elderly Peruvian HTLV-1 carrier who was diagnosed with EBV-positive diffuse large B-cell lymphoma. Despite an initial good response to therapy, patient died during treatment due to fatal Pneumocystis jirovecci pneumonia. EBV infection is characterized by B-cell lymphotropism and selective immunodeficiency. HTLV-1, on the other hand, induces T-cell dysfunction and B-cell proliferation. Finally, immunosenescence is characterized by T-cell dysregulation, decreased apoptosis and cytokine upregulation. In this elderly patient, the combination of EBV and HTLV-1 coinfection and immunosenescence may have played a role in the development of this aggressive diffuse large B-cell lymphoma. Furthermore, the immunodeficiency caused by the viral infections and chemotherapy may have played a role in developing life-threatening infectious complications.
authors: The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI, USA. bgbrady@hotmail.com
authors: Brady
authors: B
authors: Beltran
authors: Renzo
authors: R
authors: Salas
authors: Pilar
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authors: Quiñones
authors: Domingo
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authors: Morales
authors: Fernando
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authors: Hurtado
authors: Esther
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authors: Cotrina
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