title: Characterization and ligand specificity of sheep IgG2 receptor.
abstract: Neutrophils and macrophages in cattle express a novel class of immunoglobulin Fc receptor, specific for bovine IgG2, termed boFcgamma2R. In cows, the ability of neutrophils to kill immunoglobulin-opsonized microorganisms appears to depend largely on this subclass. Although related to other mammalian FcgammaRs, boFcgamma2R belongs to a novel gene family that includes the human killer Ig-like receptor and FcalphaRI (CD89) proteins. In this study, we describe the presence and characterization of this novel class of FcgammaR in sheep. The comparative analysis of this novel FcgammaR has allowed us to begin an exploration of some immunological characteristic of ruminants.
authors: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China.
authors: Songlin
authors: S
authors: Qiao
authors: Yanyan
authors: Y
authors: Yang
authors: Yunchao
authors: Y
authors: Liu
authors: Gaiping
authors: G
authors: Zhang
authors: Jun
authors: J
authors: Xi
authors: Hong
authors: H
authors: Zhang
authors: Huifang
authors: H
authors: Hao
authors: Xiaohui
authors: X
authors: Tian
authors: Suzhen
authors: S
authors: Yang
authors: Ruiguang
authors: R
authors: Deng
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019556:COS Cells; D002417:Cattle; D002522:Chlorocebus aethiops; D017931:DNA Primers / Q000235:genetics; D006801:Humans; D055261:Immunogenetic Phenomena; D007074:Immunoglobulin G / Q000378:metabolism*; D008024:Ligands; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017452:Receptors, IgG / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D012756:Sheep / Q000235:genetics* / Q000276:immunology*; D013045:Species Specificity; D014162:Transfection
chemical_list: D017931:DNA Primers; D007074:Immunoglobulin G; D008024:Ligands; D012333:RNA, Messenger; D017452:Receptors, IgG; D011994:Recombinant Proteins