A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.
Gudbjartsson
Daniel F
DF
DeCode Genetics, Reykjavik, Iceland. daniel.gudbjartsson@decode.is
Holm
Hilma
H
Gretarsdottir
Solveig
S
Thorleifsson
Gudmar
G
Walters
G Bragi
GB
Thorgeirsson
Gudmundur
G
Gulcher
Jeffrey
J
Mathiesen
Ellisiv B
EB
Njølstad
Inger
I
Nyrnes
Audhild
A
Wilsgaard
Tom
T
Hald
Erin M
EM
Hveem
Kristian
K
Stoltenberg
Camilla
C
Kucera
Gayle
G
Stubblefield
Tanya
T
Carter
Shannon
S
Roden
Dan
D
Ng
Maggie C Y
MC
Baum
Larry
L
So
Wing Yee
WY
Wong
Ka Sing
KS
Chan
Juliana C N
JC
Gieger
Christian
C
Wichmann
H-Erich
HE
Gschwendtner
Andreas
A
Dichgans
Martin
M
Kuhlenbäumer
Gregor
G
Berger
Klaus
K
Ringelstein
E Bernd
EB
Bevan
Steve
S
Markus
Hugh S
HS
Kostulas
Konstantinos
K
Hillert
Jan
J
Sveinbjörnsdóttir
Sigurlaug
S
Valdimarsson
Einar M
EM
Løchen
Maja-Lisa
ML
Ma
Ronald C W
RC
Darbar
Dawood
D
Kong
Augustine
A
Arnar
David O
DO
Thorsteinsdottir
Unnur
U
Stefansson
Kari
K
D001281:Atrial Fibrillation / Q000150:complications / Q000235:genetics*; D001483:Base Sequence; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D020521:Stroke / Q000150:complications / Q000235:genetics*
D018398:Homeodomain Proteins; C071660:ZFHX3 protein, human