title: Peripheral and central levels in nasal trigeminal sensitization and desensitization.
abstract: In order to investigate the role of central and peripheral mechanisms in nasal trigeminal sensitization/desensitization processes, the present work recorded psychophysical (intensity ratings) and psychophysiological (skin conductance) responses to allyl isothiocyanate volatile nasal stimulation--during normal breathing--in monorhinal condition after a controlateral stimulation of the other nostril. Insofar as both nostrils are anatomically separated, modifications in responses can be interpreted as a central regulation process. Results showed that sensitization was clearly related to central mechanisms contrarily to desensitization which depended only of peripheral level.
authors: Laboratoire de Neurosciences, Université de Franche-Comté, Place Leclerc 25000, Besançon, France. gerard.brand@univ-fcomte.fr
authors: G
authors: G
authors: Brand
authors: L
authors: L
authors: Jacquot
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D004056:Differential Threshold / Q000502:physiology; D005260:Female; D006801:Humans; D007509:Irritants / Q000008:administration & dosage; D017879:Isothiocyanates / Q000008:administration & dosage; D009296:Nasal Cavity / Q000294:innervation*; D011601:Psychophysics; D011603:Psychophysiology; D012684:Sensory Thresholds / Q000502:physiology*; D013268:Stimulation, Chemical; D014276:Trigeminal Nerve / Q000187:drug effects*
chemical_list: D007509:Irritants; D017879:Isothiocyanates; C004471:allyl isothiocyanate