Sclerosing stromal tumor of the ovary in a 4-year-old girl with characteristics of an ovarian signet-ring stromal tumor.
Ovarian sclerosing stromal tumor (OSST) is an extremely rare neoplasm that primarily affects young women. Signet-ring stromal tumor is another rare non-functioning benign ovarian stromal neoplasm. We report a case of a right OSST with prominent characteristics of signet-ring stromal tumor in a 4-year-old girl with symptoms of premature thelarche. We describe the clinical, histopathological, and immunohistochemical findings and review the literature. To our knowledge, the 4-year-old patient presented here is the youngest case of OSST reported in premenarchal children. The presence of non-mucin/non-lipid obvious signet-ring-like cells in this case suggests a possible relationship between OSST and signet-ring stromal tumor of the ovary.
He
Ying
Y
Department of Pathology, West China Second Hospital of Sichuan University, Chengdu, People's Republic of China. KX_Yang@hotmail.com
Yang
Kai-Xuan
KX
Jiang
Wei
W
Wang
Dan-qing
DQ
Li
Lei
L
D014408:Biomarkers, Tumor / Q000378:metabolism; D018279:Carcinoma, Signet Ring Cell / Q000378:metabolism / Q000473:pathology*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D012598:Sclerosis / Q000473:pathology; D018312:Sex Cord-Gonadal Stromal Tumors / Q000378:metabolism / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology*
D014408:Biomarkers, Tumor