Pharmacological and lifestyle factors modulating serum paraoxonase-1 activity.
Paraoxonase-1 is a lactonase and an esterase and it plays a protective role in toxicity as well as in diseases involving oxidative stress. Recently, insights into how it may be modulated by environmental factors have acquired clinical relevance. This article reviews the state-of-the-art evidence regarding PON1 modulation by pharmacological products as well as nutritional and lifestyle factors.
Camps
Jordi
J
Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, C. Sant Joan s/n, 43201 Reus, Catalunya, Spain. jcamps@grupsagessa.cat
Marsillach
Judit
J
Joven
Jorge
J
D043303:Aryldialkylphosphatase / Q000097:blood* / Q000737:chemistry; D004032:Diet; D006801:Humans; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008019:Life Style; D008958:Models, Molecular; D018384:Oxidative Stress; D011487:Protein Conformation
D000960:Hypolipidemic Agents; D043303:Aryldialkylphosphatase