Mammalian polyamine metabolism and function.
Polyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will summarize the current state of understanding of polyamine metabolism and function, the regulation of polyamine content, and heritable pathological conditions that may be derived from altered polyamine metabolism.
Pegg
Anthony E
AE
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. aep1@psu.edu
D000818:Animals; D015317:Biogenic Polyamines / Q000378:metabolism / Q000502:physiology*; D008322:Mammals
D015317:Biogenic Polyamines