title: Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.
abstract: The potential for reutericyclin derivatives to be used as topical antibiotics to treat staphylococcal skin infections was investigated. All reutericyclins inhibited the growth of clinical isolates of drug-resistant Staphylococcus aureus. Unlike the standard topical agent mupirocin, most reutericyclin derivatives eradicated staphylococcal biofilms. Moreover, two compounds formulated in hydrophilic petrolatum (10%, wt/wt) were efficacious in treating S. aureus superficial skin infections in mice. These data exemplify the prospect of developing reutericyclins as new topical antibiotics.
authors: Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA. jhurdle@utmem.edu
authors: Julian G
authors: JG
authors: Hurdle
authors: Raghunandan
authors: R
authors: Yendapally
authors: Dianqing
authors: D
authors: Sun
authors: Richard E
authors: RE
authors: Lee
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D011760:Pyrrolidinones / Q000494:pharmacology / Q000627:therapeutic use; D013207:Staphylococcal Skin Infections / Q000188:drug therapy*; D013720:Tenuazonic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones; C416127:reutericyclin; C009435:tetramic acid; D013720:Tenuazonic Acid