title: Detection of bilateral, multifocal breast cancer and assessment of tumour response to neoadjuvant chemotherapy by Tc-99m sestamibi imaging - a case report.
abstract: In breast cancer, neoadjuvant chemotherapy needs early indication for responsiveness. Tc-99m sestamibi scintimammography provides comprehensive information about the extent of disease including multiple foci in one or both breasts and possible involvement of nodes. In the present case, X-mammography was positive for a suspicious mass in the upper quadrant of the left breast only. On the other hand,Tc-99m Sestamibi scintimammography was able to depict the full extent of the disease, including its spread to the axillary lymph node, and gave useful information on the effectiveness of neoadjuvant chemotherapy. The case reported here demonstrates that Tc-99m sestamibi scintimammography was useful in detecting bilateral breast cancer and could provide additional information on possible axillary lymph node involvement. Furthermore, Tc-99m sestamibi scintimammography was effective in monitoring response to chemotherapy in the studied case.
authors: Regional Cetre of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy.
authors: Mariano
authors: M
authors: Grosso
authors: Muhammad Babar
authors: MB
authors: Imran
authors: Duccio
authors: D
authors: Volterrani
authors: Manuela
authors: M
authors: Roncella
authors: Khalid
authors: K
authors: Abufalgha
authors: Gaia
authors: G
authors: Grassetto
authors: Adil
authors: A
authors: Al-Nahhas
authors: Domenico
authors: D
authors: Rubello
authors: Giuliano
authors: G
authors: Mariani
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011379:Prognosis; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D004317:Doxorubicin; D003520:Cyclophosphamide; D017256:Technetium Tc 99m Sestamibi; D005472:Fluorouracil