title: Kramers-like turnover in load-dependent activated dynamics.
abstract: Recent advancement of experimental techniques at the single molecule level has demonstrated how an external load affects a chemical reaction which controls the transport of biological motor proteins. Majority of these studies are concerned with thermodynamically open systems. We have examined a prototype model reaction in terms of inertial Brownian motion of a particle in a force field subjected to an overdamped motion of a viscous load coupled harmonically to the particle. A general analytical expression for the rate constant has been derived to demonstrate that depending on the strength of harmonic coupling and drag coefficient of the load a Kramers-like turnover can be realized in the spatial diffusion-limited regime. The turnover reduces to a crossover between the two states characterized by zero-load and finite load conditions.
authors: Department of Physical Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India.
authors: Debasish
authors: D
authors: Mondal
authors: Pulak Kumar
authors: PK
authors: Ghosh
authors: Deb Shankar
authors: DS
authors: Ray
mesh_terms: D000465:Algorithms; D004548:Elasticity; D007700:Kinetics; D008954:Models, Biological; D010316:Particle Size; D011506:Proteins / Q000737:chemistry* / Q000502:physiology*; D014783:Viscosity
chemical_list: D011506:Proteins