title: Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer.
abstract: Using exciton-coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host-guest complex formed with (+)-(S)-methamphetamine produced a negative bisignate-shaped ECCD spectrum, whereas the complex formed with (-)-(R)-methamphetamine produced a positive one. This sensitive technique could serve as an alternative method for the enantiodiscrimination of chiral methamphetamine, a commonly abused drug in the United States.
authors: Department of Chemistry, Doane College, Crete, Nebraska 68333, USA.
authors: Marcus
authors: M
authors: Anderson
authors: Katie
authors: K
authors: Wilcox
authors: Mike
authors: M
authors: Guericke
authors: Han
authors: H
authors: Chu
authors: Mark V
authors: MV
authors: Wilson
authors: Erin
authors: E
authors: Wilson
authors: Kerry
authors: K
authors: Lucas
authors: Andrea E
authors: AE
authors: Holmes
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods; D002942:Circular Dichroism / Q000379:methods*; D004337:Drug Carriers; D009682:Magnetic Resonance Spectroscopy; D008694:Methamphetamine / Q000032:analysis* / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry*; D012044:Regression Analysis; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013237:Stereoisomerism; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D004337:Drug Carriers; D011166:Porphyrins; D008694:Methamphetamine