Genetic rearrangement MLL/AF4 is most frequent in children with acute lymphoblastic leukemias in Mexico City.
One of the highest incidences of acute lymphoblastic leukemia (ALL) in the world has been reported in Mexico City. In the current study (26 cases), the frequencies of the most frequent genetic rearrangements TEL-AML1, MLL/AF4, BCR-ABL (major and minor) in ALL in children from Mexico City were determined. For the ALL, the frequency of MLL/AF4 was 65.4%, for TEL-AML1 and that of BCR/ABL was 3.8%. Only 6 of the 17 children with the MLL/AF4 rearrangement were less than 26 months old. The frequency reported for MLL/AF4 in Mexican children with ALL is one of the highest worldwide. These findings could potentially explain the higher frequency of ALL with poor prognosis for children in Mexico City.
Daniel-Cravioto
Alondra
A
Unidad de Investigación Biomédica en Infectología e Inmunología, Unidad Medica de Alta Especialidad (UMAE), Hospital de Infectología Daniel Mendez Hernandez del Centro Medico Nacional La Raza, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
Gonzalez-Bonilla
Cesar R
CR
Mejia-Arangure
Juan Manuel
JM
Perez-Saldivar
Maria Luisa
ML
Fajardo-Gutierrez
Arturo
A
Jimenez-Hernandez
Elva
E
Hernandez-Serrano
Milagros
M
Bekker-Mendez
Vilma Carolina
VC
D000293:Adolescent; D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000235:genetics*; D001724:Birth Weight; D002648:Child; D002675:Child, Preschool; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics; D004781:Environmental Exposure; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008969:Molecular Sequence Data; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000196:embryology / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic; D014505:Urban Population; D000097764:ETS Translocation Variant 6 Protein
D014408:Biomarkers, Tumor; D050676:Core Binding Factor Alpha 2 Subunit; D016044:Fusion Proteins, bcr-abl; D051788:Myeloid-Lymphoid Leukemia Protein; D015514:Oncogene Proteins, Fusion; C113855:MLL-AF4 fusion protein, human; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein