Membrane fusion and fission: enveloped viruses.
Membrane fusion and fission are two key processes that occur during the replication of enveloped viruses, namely access to the interior of the host-cell (entry, which requires fusion of the viral envelope with the target cell envelope) and dissemination of viral progeny after replication (egress, which involves budding and fission). These dynamic processes are mediated by specialized proteins that modify and bend the lipid bilayer transiently and locally. This review focuses on fusion and fission reactions and on the hypothetical shared mechanism that generates their driving force.
Falanga
Annarita
A
Department of Biological Sciences, Division of Biostructures and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi - University of Naples Federico II, and Istituto di Biostrutture e Bioimmagini - CNR, Via Mezzocannone 16, Napoli 80134, Italy.
Cantisani
Marco
M
Pedone
Carlo
C
Galdiero
Stefania
S
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D005089:Exocytosis; D008561:Membrane Fusion; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology; D014759:Viral Envelope Proteins / Q000378:metabolism; D053586:Virus Internalization; D014780:Viruses / Q000378:metabolism*
D010455:Peptides; D014759:Viral Envelope Proteins