HLA-G 3' UTR haplotypes and HIV vertical transmission.
We evaluated the possible association of human leukocyte antigen-G (HLA-G) 3777G>C and 14-bp deletion/insertion (D/I) polymorphisms haplotypes and combined genotypes with perinatal HIV transmission in Brazilian children. The 3777G>C polymorphism alone has no effect on HIV vertical transmission but, when linked with the D allele, exerts a positive role in the protection. Indeed, we identified the DC HLA-G haplotype as significantly associated with a protective effect towards HIV vertical transmission.
Segat
Ludovica
L
Genetic Service, IRCCS Burlo Garofolo, Trieste, Italy.
Catamo
Eulalia
E
Fabris
Annalisa
A
Padovan
Lara
L
Morgutti
Marcello
M
Crovella
Sergio
S
D020413:3' Untranslated Regions / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics / Q000635:transmission* / Q000821:virology; D015497:HIV-1; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D015810:Linkage Disequilibrium; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D020413:3' Untranslated Regions; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I