title: [Study on radiation sensitivity of colorectal cancer cells using gene expression profile].
abstract: OBJECTIVE
  To screen the radiosensitivity-related genes of colorectal cancer cells.
  
  
  METHODS
  Gene expression profiles of two different radiosensitivity cells(colorectal cancer cell line Lovo and SW480) were obtained by cDNA array and the differences of gene expression profiles between the two cells were analyzed.
  
  
  RESULTS
  Genes of more than 2-fold expressive differentiation were screened. In Lovo cells, 908 up-regulated genes were found, including higher expression genes CEACAM5, THBS1, SERPINE2, ARL7, HPGD, while 1312 genes were down-regulated. In SW480 cells, higher expression genes were SCD, NQ01, LYZ, KRT20 and ATP1B1.
  
  
  CONCLUSIONS
  Gene profiles can reflect the radiosensitivity of colorectal cancer cells, which will provide the choice for the further study of radiosensitivity in colorectal cancer.
authors: Department of General Surgery, The Second Affiliated Hospital, Suzhou University, Suzhou 215004, China.
authors: Xiao-dong
authors: XD
authors: Yang
authors: Chun-gen
authors: CG
authors: Xing
authors: Wei
authors: W
authors: Gong
authors: Li-ying
authors: LY
authors: Zhou
authors: Yong-you
authors: YY
authors: Wu
authors: Kui
authors: K
authors: Zhao
mesh_terms: D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000235:genetics*; D015870:Gene Expression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011836:Radiation Tolerance / Q000235:genetics*