title: NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma.
abstract: Environmental tobacco smoke (ETS) exposure might increase the risk for childhood asthma, and we hypothesized the effect may be modified by the phase II genes NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione S-transferase (GST) M1. To investigate the genetic and environmental associations with asthma, GSTM1 and NQO1 functional polymorphisms and ETS were analyzed in a two-staged cross-sectional study among elementary schoolchildren in Taiwan. Multiple logistic regression analysis revealed a significant association between the Ser allele of the NQO1 Pro187Ser polymorphism and asthma (OR=1.6, 95% CI 1.3-1.8). Although GSTM1 genotype itself was not significantly associated with asthma (OR=1.0, 95% CI 0.8-1.1), the GSTM1 genotype modified the association between the NQO1 polymorphism and asthma in children exposed to ETS (p=0.0002). The NQO1 gene might be involved in the development of asthma, especially in children carrying the GSTM1 null genotype who are exposed to ETS.
authors: Institute of Environmental Health, China Medical University, 91 Hsieh-Shih Road, Taichung 404, Taiwan.
authors: Yu-Fen
authors: YF
authors: Li
authors: Pei-Jung
authors: PJ
authors: Tseng
authors: Che-Chen
authors: CC
authors: Lin
authors: Chiao-Ling
authors: CL
authors: Hung
authors: Sheng-Che
authors: SC
authors: Lin
authors: Wan-Cing
authors: WC
authors: Su
authors: Yi-Ling
authors: YL
authors: Huang
authors: Fung-Chang
authors: FC
authors: Sung
authors: Chien-Kuo
authors: CK
authors: Tai
mesh_terms: D001249:Asthma / Q000139:chemically induced* / Q000235:genetics; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014028:Tobacco Smoke Pollution
chemical_list: D005982:Glutathione Transferase; D016660:NAD(P)H Dehydrogenase (Quinone); D014028:Tobacco Smoke Pollution; C447479:NQO1 protein, human