title: Disseminated histiocytic sarcoma with excessive hemophagocytosis in a cat.
abstract: A 10-year-old Japanese domestic cat was presented with anorexia and weight loss. Severe anemia and thrombocytopenia were detected. Abdominal radiography and ultrasonography revealed the presence of multiple masses in the spleen. Cytological analyses of the masses revealed several atypical histiocytic cells and considerable hemophagocytosis. A splenectomy was performed, and the mass was diagnosed as histiocytic sarcoma on the basis of histopathological, cytochemical and immunohistochemical analyses. Further, abnormal hemophagocytosis was observed in the bone marrow. The cat was administered prednisolone and lomustine, and it survived for 107 days after admission. An autopsy revealed the presence of neoplastic histiocytic cells in the bone marrow, liver, pancreatic lymph node and glomeruli. This is the first case of histiocytic sarcoma in a cat to be reported in Japan.
authors: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
authors: Kaori
authors: K
authors: Ide
authors: Asuka
authors: A
authors: Setoguchi-Mukai
authors: Takayuki
authors: T
authors: Nakagawa
authors: Koji
authors: K
authors: Uetsuka
authors: Hiroyuki
authors: H
authors: Nakayama
authors: Yasuhito
authors: Y
authors: Fujino
authors: Koichi
authors: K
authors: Ohno
authors: Hajime
authors: H
authors: Tsujimoto
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy / Q000473:pathology*; D002415:Cats; D017809:Fatal Outcome; D005260:Female; D054747:Histiocytic Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D006651:Histocytochemistry / Q000662:veterinary; D008130:Lomustine / Q000627:therapeutic use; D051359:Lymphohistiocytosis, Hemophagocytic / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D013160:Splenic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008130:Lomustine