New azaphilones, seco-chaetomugilins A and D, produced by a marine-fish-derived Chaetomium globosum.
Seco-chaetomugilins A and D were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, along with the chemical transformation from known chaetomugilins A and D. Seco-chaetomugilin D exhibited growth inhibitory activity against cultured P388, HL-60, L1210, and KB cells.
Yamada
Takeshi
T
Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. yamada@glu.oups.ac.jp
Muroga
Yasuhide
Y
Tanaka
Reiko
R
D000818:Animals; D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D002597:Chaetomium / Q000737:chemistry*; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010860:Pigments, Biological / Q000737:chemistry* / Q000494:pharmacology*; D023701:Smegmamorpha / Q000382:microbiology
D001572:Benzofurans; D001578:Benzopyrans; D010860:Pigments, Biological; C494154:azaphilone; C545836:seco-chaetomugilin A; C545837:seco-chaetomugilin D