title: Hyperglycaemia in acute ischaemic stroke is associated with an increased 5-year mortality.
abstract: BACKGROUND
  admission hyperglycaemia (HG) is associated with worse prognosis and higher mortality within 3 months after stroke. Reports on long-term mortality are inconsistent.
  
  
  OBJECTIVE
  to evaluate the influence of admission HG [blood glucose (BG) levels >8 mmol/L] on long-term mortality after ischaemic stroke (IS) and transient ischaemic attack (TIA).
  
  
  METHODS
  consecutive patients with IS or TIA, admitted from January 1997 until December 2002, were retrospectively screened. BG was measured within 3 days from onset of symptoms. Information on the date of death was obtained within 10 years after onset.
  
  
  RESULTS
  a total of 509 patients (78% IS; 22% TIA) were included. Admission HG was present in 28% and 18% of the IS and TIA patients, respectively (P = 0.05). Mean admission BG was 7.6 +/- 3.2 mmol/L in the IS and 6.7 +/- 2.3 mmol/L in TIA (P = 0.002). During a mean observation of 66 +/- 35 months, the overall 1- and 10-year mortality rate was 12% and 51% in IS compared to 4% and 38% in TIA patients (P = 0.004). Normoglycaemic IS patients had a longer median survival than those with HG (113 vs 84 months, P = 0.04). Admission HG did not affect the mortality rates in TIA patients.
  
  
  CONCLUSIONS
  admission HG is associated with greater mortality rates up to 5 years after stroke but does not influence the survival of TIA patients.
authors: Department of Neurology, Neuro-Angiological Research Center, Karolinska Institutet at Karolinska University Hospital, Huddinge, Sweden. Nikolaos.Kostulas@ki.se
authors: Nikolaos
authors: N
authors: Kostulas
authors: Ioanna
authors: I
authors: Markaki
authors: Helen
authors: H
authors: Cansu
authors: Thomas
authors: T
authors: Masterman
authors: Vasilios
authors: V
authors: Kostulas
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D002545:Brain Ischemia / Q000401:mortality*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000401:mortality*; D002546:Ischemic Attack, Transient / Q000401:mortality*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D020521:Stroke / Q000401:mortality*; D055815:Young Adult
chemical_list: D001786:Blood Glucose