title: [Promotive excretion of causative agents of Yusho by intake of fermented brown rice with Aspergillus oryze in patients with Yusho --with regard to PCDFs and PCDDs].
abstract: Forty years have passed since the outbreak of Kanemi rice oil poisoning, namely, Yusho in the western Japan. However, even now the patients with Yusho have been still suffering from several objective and subjective symptoms. In order to improve or, if possible, to cure such symptoms, the most important therapeutic treatment is considered to actively excrete the causative agents, that is, polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzo-p-dioxins (PCDDs) from the bodies of the patients and to reduce their body burdens. In rats, chlorophyll and dietary fiber have been shown to promote the fecal excretion of PCDFs and PCDDs and to reduce their levels in rats. In this study, we have examined whether such kinds of effect are also observed by fermented brown rice with Aspergillus oryzae (FBRA) containing 5% spirulina, which is so-called spirulina HI*GENKI, the health food and relatively rich with chlorophyll and dietary fiber, in eighteen patients with Yusho. They were divided into two groups, namely group A, ten patients (3 males and 7 females) with the mean age of 67.7 years old and group B, eight patients (4 males and 4 females) with the mean age of 64.1 years old. Respective mean concentrations of the three PCDF congeners, that is, 2,3,4,7,8-PenCDF, 1, 2,3,4,7,8-HxCDF and 1,2,3,6,7,8-HxCDF in the blood on lipid weight basis just before initiating this study were as follows; group A: 413, 152 and 45.7 pg/g lipid, and group B: 151, 42.7 and 17.3 pg/g lipid. Contamination levels of these PCDF congeners in group A were 2.6 to 3.6 times higher than those in group B. In respective mean concentrations of PCDFs, PCDDs and PCDFs/DDs in both groups were as follows; group A: 228, 30.9 and 258 pg-TEQ/g lipid, and group B: 82.4, 19.7 and 102 pg-TEQ/g lipid. Contamination levels of PCDFs and PCDDs were around 2 times higher in group A than in group B. Group A took around 7.0 g of spirulina HI*GENKI after each meal and tree times a day for the first one year and for the second one year, they did not take spirulina HI*GENKI any more. Group B took spirulina HI*GENKI with the same manner as the group A only for the second one year. The concentrations of PCDFs and PCDDs in the blood of groups A and B were also measured at the end of the first and second year, respectively. Assuming the body fat is also contaminated with PCDFs and PCDDs at their concentrations on lipid weight basis in the blood and the content of body fat is 20% of 60 kg body weight, we computed the average amounts in the net excretion of PCDFs and PCDFs/DDs from the body of the patients due to the intake of spirulina HI*GENKI in groups A and B. As a result, in group A, 85.0 and 99.6 ng-TEQ/patient, respectively were excreted from the body of the patients. In group B, only 38.1 nd 40.0 ng-TEQ/patient were excreted. Accordingly, promotive excretion of PCDFs and PCDDs from the patients with Yusho seemed much effective in group A, of which their concentrations in the blood were much higher than those of group B.
authors: Laboratory of Environmental Molecular Epidemiology, School of Health Sciences, Graduate School of Medical Sciences, Kyushu University.
authors: Junya
authors: J
authors: Nagayama
authors: Hironori
authors: H
authors: Hirakawa
authors: Jumboku
authors: J
authors: Kajiwara
authors: Takao
authors: T
authors: Iida
authors: Takashi
authors: T
authors: Todaka
authors: Takeshi
authors: T
authors: Uenotsuchi
authors: Satoko
authors: S
authors: Shibata
authors: Hiroshi
authors: H
authors: Tsuji
authors: Teruaki
authors: T
authors: Iwasaki
mesh_terms: D000818:Animals; D001236:Aspergillus oryzae; D001572:Benzofurans / Q000378:metabolism*; D000072338:Dibenzofurans, Polychlorinated; D004043:Dietary Fiber / Q000627:therapeutic use; D019587:Dietary Supplements; D004147:Dioxins / Q000506:poisoning*; D004785:Environmental Pollutants / Q000378:metabolism*; D005260:Female; D005285:Fermentation; D005506:Food Contamination; D006801:Humans; D008297:Male; D008875:Middle Aged; D012275:Oryza; D011078:Polychlorinated Biphenyls / Q000506:poisoning*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D053545:Spirulina
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004043:Dietary Fiber; D004147:Dioxins; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls