Mighty mouse.
In this issue of Blood, ter Brugge and colleagues describe the results of their efforts to express SV40 T antigen in mature B cells of mice. As a consequence of T antigen expression, B cells develop normally but, upon aging, mice show an accumulation of monoclonal CD5(+) B cells and have a chronic lymphocytic leukemia-like phenotype.
Johnson
Amy J
AJ
Ohio State University, Ohio, USA.