Re-evaluation of the role of STOX1 transcription factor in placental development and preeclampsia.
Preeclampsia is a common disease of pregnancy, characterized by high blood pressure and proteinuria appearing from the second trimester of gestation. Preeclampsia has been shown to have a strong genetic component. In 2005 a positional cloning project led to the discovery of the STOX1 transcription factor, and mutations of this gene were proposed as causal for preeclampsia in Dutch families. Despite the publication of three contradictory studies, we have shown by analyzing the functional effects of STOX1 that its overexpression in choriocarcinoma cells recapitulates several transcriptomic aspects of preeclampsia. In this review, the current literature is analyzed to evaluate the possible involvement of STOX1 in the pathogenesis of this disease. While preeclampsia obviously cannot be considered as a disease caused by mutation in a single gene, we argue that STOX1 may be at the center of common pathways leading to preeclampsia.
Rigourd
Virginie
V
Equipe 21, Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France.
Chelbi
Sonia
S
Chauvet
Caroline
C
Rebourcet
Régis
R
Barbaux
Sandrine
S
Bessières
Bettina
B
Mondon
Françoise
F
Mignot
Thérèse-Marie
TM
Danan
Jean-Louis
JL
Vaiman
Daniel
D
D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D010929:Placentation / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D021381:Protein Transport; D014158:Transcription, Genetic
D002352:Carrier Proteins; C500784:STOX1 protein, human