High prevalence of impaired fasting glucose in Chinese children and adolescents with prehypertension/hypertension.
OBJECTIVE
To assess the prevalence of impaired fasting glucose among Chinese children and adolescents with prehypertension/hypertension (PHP/HP), overweight/obesity (OW/OB) or both in the general population.


METHODS
In total, 3409 children and adolescents among the age group of 10-18 years were enrolled. These subjects were then divided into four groups: OW/OB, PHP/HP, OW/OB + PHP/HP and a control group. Fasting plasma glucose (FPG) and lipid levels were measured in children with a body mass index > or =85th percentile and/or blood pressure > or =90th percentile and in 100 subjects randomly selected from the control group. The oral glucose tolerance test was performed in all the subjects with fasting glucose > or =5.6 mmol/L.


RESULTS
Eighty-one impaired fasting glucose subjects and one girl with type 2 diabetes were identified. The prevalence of impaired fasting glucose in PHP/HP (7.03%) was not significantly different from that in the OW/OB + PHP/HP group (8.59%), but was higher than that in the OW/OB group (3.31%).


CONCLUSIONS
Although the American Diabetes Association does not recommend the FPG test for children and adolescents with PHP/HP, in this study, we found that children and adolescents with PHP/HP have a higher prevalence of impaired fasting glucose than those with OW/OB. Further validation of these findings is warranted and a type 2 diabetes screening protocol for Chinese children and adolescents needs to be established.
Zhao
Lei
L
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Ma
Ya-Hong
YH
Xu
Jian-Xin
JX
Li
Shu-Bo
SB
Yang
Jin-Kui
JK
D000293:Adolescent; D000704:Analysis of Variance; D044466:Asian People / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000208:ethnology*; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000208:ethnology*; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000208:ethnology*; D050177:Overweight / Q000208:ethnology*; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution; D011795:Surveys and Questionnaires
D008055:Lipids