title: [Changes of nitric oxide and endothelin serum level after carotid balloon denudation or stent assisted angioplasty: an experimental and clinical observation].
abstract: OBJECTIVE
  To observe the changes of nitric oxide (NO) and endothelin (ET) serum level in the Guangxi BA-MA minipigs whose carotid arteries were injured by balloon denudation and in the patients with carotid stent assisted angioplasty.
  
  
  METHODS
  Twelve Guangxi BA-MA minipigs were chosen. High fat/cholesterol feeding and endovascular balloon denudation were used to create a carotid artery atherosclerotic stenosis animal model. Blood samples were collected from peripheral veins before starting the procedure, and again, at 2 and 3 weeks after the procedure, respectively. Serum NO and ET concentrations of blood samples were tested. Nineteen patients with carotid artery stenosis who underwent stent assisted angioplasty were randomly selected, and their serum NO and ET were tested using the same methods as above.
  
  
  RESULTS
  In the animal group, there was a significant decrease of mean NO concentration at 2 weeks after carotid injury (t-test, P < 0.05), however, no significant change of ET was observed. A very significant increase of ET was observed at 3 weeks after the procedure (t-test, P < 0.01). In the patient group, there were no significant differences among serum NO or ET concentration of peripheral vein blood before, immediately after, and 6 h after the endovascular treatment.
  
  
  CONCLUSIONS
  In this study, a decrease of NO concentration and an increase of ET concentration of peripheral vein blood are found in BA-MA minipigs after carotid arteries are injured by balloon denudation, which might be a cue for the formation of atherosclerosis. However, no significant changes are observed in this group of patients who underwent carotid angioplasty treatment. Therefore, further studies are needed.
authors: Department of Neurosurgery, Beijing Hospital, Ministry of Health, Beijing 100730, China.
authors: Jia-Chun
authors: JC
authors: Liu
authors: Da-Ming
authors: DM
authors: Wang
authors: Jiang-Nan
authors: JN
authors: Qian
authors: Ya-Guo
authors: YG
authors: Li
authors: Li-Jun
authors: LJ
authors: Wang
authors: Xue-Li
authors: XL
authors: Jiang
authors: Le-le
authors: LL
authors: Zhai
authors: Jun
authors: J
authors: Lu
authors: Peng
authors: P
authors: Qi
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon; D000818:Animals; D002339:Carotid Arteries / Q000601:surgery; D016893:Carotid Stenosis / Q000097:blood* / Q000601:surgery; D004195:Disease Models, Animal; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D011184:Postoperative Period; D011897:Random Allocation; D015607:Stents; D013552:Swine; D013556:Swine, Miniature
chemical_list: D016232:Endothelins; D009569:Nitric Oxide