[Estimated half-life of penta-chlorodibenzofuran (PeCDF) and simulation of PeCDF excretion].
The half-life of 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in the Yusho patients has been reported to be approximately seven years. In the present study, we estimated the half-life of PeCDF using data from the medical check-ups of more than 300 Yusho patients. We performed linear regression analysis with a binary logarithm of PeCDF blood level in Yusho patients as the dependent variable, and the measurement year as the independent variable. Our results showed that there were many patients who had shown no reduction of their blood PeCDF level for several years. This result contradicts the previously reported half-life period. Therefore, we believe that a more complicated excretion model needs to be established to explain the discrepancy we found. We hypothesized that there might be two mechanisms of PeCDF assimilation in human digestive tract. In the present study, we also used our hypothesis to simulate PeCDF excretion in Yusho patients.
Akahane
Manabu
M
Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine, Japan. makahane@naramed-u.ac.jp
Matsumoto
Shinya
S
Kanagawa
Yoshiyuki
Y
Kajiwara
Jumboku
J
Todaka
Takashi
T
Hirakawa
Hironori
H
Koike
Soichi
S
Furue
Masutaka
M
Imamura
Tomoaki
T
D001572:Benzofurans / Q000097:blood / Q000378:metabolism*; D004147:Dioxins / Q000378:metabolism* / Q000506:poisoning*; D005506:Food Contamination; D006207:Half-Life; D006801:Humans; D008962:Models, Theoretical; D011078:Polychlorinated Biphenyls / Q000506:poisoning*
D001572:Benzofurans; D004147:Dioxins; D011078:Polychlorinated Biphenyls; C038890:2,3,4,7,8-pentachlorodibenzofuran