title: Evidence for human microRNA-offset RNAs in small RNA sequencing data.
abstract: MicroRNA-offset-RNAs (moRNAs) were recently detected as highly abundant class of small RNAs in a basal chordate. Using short read sequencing data, we show here that moRNAs are also produced from human microRNA precursors, albeit at quite low expression levels. The expression levels of moRNAs are unrelated to those of the associated microRNAs. Surprisingly, microRNA precursors that also show moRNAs are typically evolutionarily old, comprising more than half of the microRNA families that were present in early Bilateria, while evidence for moRNAs was found only for a relative small fraction of microRNA families of recent origin.
authors: Department of Computer Science, University of Leipzig, Leipzig, Germany.
authors: David
authors: D
authors: Langenberger
authors: Clara
authors: C
authors: Bermudez-Santana
authors: Jana
authors: J
authors: Hertel
authors: Steve
authors: S
authors: Hoffmann
authors: Philipp
authors: P
authors: Khaitovich
authors: Peter F
authors: PF
authors: Stadler
mesh_terms: D006801:Humans; D035683:MicroRNAs / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000737:chemistry*; D017423:Sequence Analysis, RNA
chemical_list: D035683:MicroRNAs; D034741:RNA, Small Interfering; D012313:RNA