CD40 and autoimmunity: the dark side of a great activator.
CD40 is a tumor necrosis factor receptor superfamily member expressed by immune and non-immune cells. CD40:CD154 interactions mediate T-dependent B cell responses and efficient T cell priming. Thus, CD40 is a likely candidate to play roles in autoimmune diseases in which activated T and B cells cause pathology. Diseases in which CD40 plays a pathogenic role include autoimmune thyroiditis, type 1 diabetes, inflammatory bowel disease, psoriasis, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. This review discusses the role of CD40:CD154 interaction in human and mouse autoimmunity, human polymorphisms associated with disease incidence, and disrupting CD40:CD154 interactions as an autoimmune therapy.
Peters
Anna L
AL
Immunology Graduate Program and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA.
Stunz
Laura L
LL
Bishop
Gail A
GA
D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D019013:CD40 Antigens / Q000276:immunology*; D023201:CD40 Ligand / Q000276:immunology*; D006801:Humans; D051379:Mice
D019013:CD40 Antigens; D023201:CD40 Ligand