Synthetic studies on vincorine: access to the 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole skeleton.
Synthetic studies on vincorine are described; the conversion of 3-aminoethyl-3-alkyloxindoles to 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indoles has been achieved through an addition-cyclization sequence, and a fully functionalized key intermediate was constructed with this method.
Yasui
Yoshizumi
Y
WPI Advanced Institute for Materials Research, Tohoku University, Japan.
Kinugawa
Tomoyo
T
Takemoto
Yoshiji
Y
D007211:Indoles / Q000737:chemistry*; D014748:Vinca Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry
D007211:Indoles; D014748:Vinca Alkaloids; C543267:vincorine