title: Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese.
abstract: A recent whole-genome association study identified a strong association between polymorphisms in the prostate stem cell antigen (PSCA) gene and stomach cancer risk. In this case-control study, we aimed to validate this association, and further to explore environmental factors possibly interacting with PSCA polymorphisms in 708 incident stomach cancer cases and 708 age-sex matched controls. The association between PSCA polymorphisms and Helicobacter pylori infection was also examined. We found that rs2294008 and rs2976392, which were strongly linked to each other (D' = 1.00), were significantly associated with stomach cancer risk. Per allele odds ratio for rs2994008 was 1.40 (95% confidence interval: 1.19-1.65; p = 3.7 x 10(-5)). We found significant interaction with a family history of stomach cancer in first-degree relatives (p-heterogeneity = 0.009). Similar to originally reported association, we found significant heterogeneity between diffuse and intestinal type (p-heterogeneity = 0.007). No association was seen between PSCA polymorphisms and H. pylori infection. In conclusion, PSCA polymorphisms are associated with stomach cancer risk in Japanese. A possible interaction with family history warrants further evaluation.
authors: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan. t-suzuki@aichi-cc.jp
authors: Keitaro
authors: K
authors: Matsuo
authors: Kazuo
authors: K
authors: Tajima
authors: Takeshi
authors: T
authors: Suzuki
authors: Takakazu
authors: T
authors: Kawase
authors: Miki
authors: M
authors: Watanabe
authors: Kohei
authors: K
authors: Shitara
authors: Kazunari
authors: K
authors: Misawa
authors: Seiji
authors: S
authors: Ito
authors: Akira
authors: A
authors: Sawaki
authors: Kei
authors: K
authors: Muro
authors: Tsuneya
authors: T
authors: Nakamura
authors: Kenji
authors: K
authors: Yamao
authors: Yoshitaka
authors: Y
authors: Yamamura
authors: Nobuyuki
authors: N
authors: Hamajima
authors: Akio
authors: A
authors: Hiraki
authors: Hideo
authors: H
authors: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm; D016022:Case-Control Studies; D005260:Female; D058851:GPI-Linked Proteins; D016481:Helicobacter Infections / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D007414:Intestinal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D055815:Young Adult
chemical_list: D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; C110843:PSCA protein, human