title: Calcineurin contributes to spatial memory impairment induced by rapid eye movement sleep deprivation.
abstract: Recent evidence suggests that rapid eye movement (REM) sleep deprivation (REMSD) causes learning and memory deficits. However, the mechanism of REMSD-induced memory impairment remains unclear. Calcineurin (CaN) is involved in synaptic plasticity and is known as a negative constraint on learning and memory. Here we report that 72 h REMSD by the modified multiple platform method in rats resulted in spatial memory impairment in the Morris water maze and elevated hippocampal cytosolic CaN activity, both of which were reversed after 18 h sleep recovery. CaN expression in the whole-tissue homogenate of the hippocampus was not altered by REMSD. The results suggest that elevated hippocampal CaN activity is involved in REMSD-induced spatial memory impairment.
authors: Department of Neurology, Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, Shanghai, PR China.
authors: Gui-Ping
authors: GP
authors: Wang
authors: Liu-Qing
authors: LQ
authors: Huang
authors: Hui-Juan
authors: HJ
authors: Wu
authors: Lin
authors: L
authors: Zhang
authors: Zhen-Dong
authors: ZD
authors: You
authors: Zhong-Xin
authors: ZX
authors: Zhao
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D015153:Blotting, Western; D019703:Calcineurin / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000502:physiology; D012892:Sleep Deprivation / Q000150:complications / Q000378:metabolism*; D013028:Space Perception / Q000502:physiology; D013997:Time Factors
chemical_list: D019703:Calcineurin