title: Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates.
abstract: A useful Michael addition reaction using nitroalkanes as the nucleophile and 4-oxo-enoates as the Michael acceptor has been disclosed, and the reaction allows expedient access to functionalized chiral gamma-keto esters in high yields and excellent enantioselectivities (up to 98% ee), with a low catalyst loading.
authors: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
authors: Hai-Hua
authors: HH
authors: Lu
authors: Xu-Fan
authors: XF
authors: Wang
authors: Chang-Jiang
authors: CJ
authors: Yao
authors: Jian-Ming
authors: JM
authors: Zhang
authors: Hong
authors: H
authors: Wu
authors: Wen-Jing
authors: WJ
authors: Xiao
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D002087:Butyrates / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D009574:Nitro Compounds / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C508635:6-(nitrooxy)hexyl-(2z)-4-(acetyloxy)-3-(4-(methylsulfonyl)phenyl)-2-phenylbut-2-enoate; D000473:Alkanes; D002087:Butyrates; D009574:Nitro Compounds; D009930:Organic Chemicals