Central regulation of ejaculation and the therapeutic role of serotonergic agents in premature ejaculation.
Premature ejaculation (PE) is characterized by a short ejaculatory latency time, poor control over ejaculation and a negative impact on quality of life. The process of ejaculation is under central control, and serotonin (5-HT) is a key mediator; therefore, SSRIs and tricyclic antidepressants, including paroxetine, sertraline and clomipramine, are commonly used with chronic daily dosing in the treatment of PE. Dapoxetine, a short-acting SSRI that acts supraspinally to inhibit ejaculation, has been approved in several European countries for on-demand treatment of PE. With a range of centrally acting treatment options, treatment should be tailored to meet the needs and preferences of individual patients.
Patel
Kush
K
Tulane University, Department of Urology, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Hellstrom
Wayne J G
WJ
D000928:Antidepressive Agents / Q000627:therapeutic use*; D001596:Benzylamines / Q000009:adverse effects / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002986:Clinical Trials as Topic; D004542:Ejaculation / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000009:adverse effects / Q000627:therapeutic use; D018377:Neurotransmitter Agents / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology; D018490:Serotonin Agents / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*
D000928:Antidepressive Agents; D001596:Benzylamines; D009281:Naphthalenes; D018377:Neurotransmitter Agents; D018490:Serotonin Agents; D017367:Selective Serotonin Reuptake Inhibitors; C080598:dapoxetine