title: Mitochondrial transport dynamics in axons and dendrites.
abstract: Mitochondrial dynamics and transport have emerged as key factors in the regulation of neuronal differentiation and survival. Mitochondria are dynamically transported in and out of axons and dendrites to maintain neuronal and synaptic function. Transport proceeds through a controlled series of plus- and minus-end directed movements along microtubule tracks (MTs) that are often interrupted by short stops. This bidirectional motility of mitochondria is facilitated by plus end-directed kinesin and minus end-directed dynein motors, and may be coordinated and controlled by a number of mechanisms that integrate intracellular signals to ensure efficient transport and targeting of mitochondria. In this chapter, we discuss our understanding of mechanisms that facilitate mitochondrial transport and delivery to specific target sites in dendrites and axons.
authors: Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, AZ 85721, USA. kez@neurobio.arizona.edu
authors: Konrad E
authors: KE
authors: Zinsmaier
authors: Milos
authors: M
authors: Babic
authors: Gary J
authors: GJ
authors: Russo
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D001692:Biological Transport; D002465:Cell Movement; D003712:Dendrites / Q000502:physiology*; D006801:Humans; D016547:Kinesins / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*; D020409:Molecular Motor Proteins / Q000502:physiology*
chemical_list: D020409:Molecular Motor Proteins; D016547:Kinesins