[Increasing cardiopulmonary bypass flow volume improves outcome of patient with carotid stenosis undergoing coronary artery bypass grafting].
OBJECTIVE
To evaluate the effect of increasing cardiopulmonary bypass (CPB) flow volume in improving outcome of patients with carotid artery stenosis performed coronary artery bypass grafting (CABG) procedure.


METHODS
Fifty-one patients data collected from January 2006 to March 2008 and divided into two groups (A and B) based on the degree of the carotid artery stenosis diagnosed by ultrasound. Group A included 15 cases with one or both carotid artery stenosis more than 50%, 14 male and 1 female, aged (68.5 +/- 7.7) years old, 14 with hypertension, 2 with diabetes, 6 with myocardial infarction, 3 with cerebral infarction. Group B included 36 cases with stenosis less than 50%, 34 male and 2 female, aged (62.4 +/- 10.2) years old, 28 with hypertension, 7 with diabetes, 20 with myocardial infarction. Increasing CPB flow volume in A group to compare cerebral blood flow (CBF) within procedure in both groups.


RESULTS
CPB flow volume in group A was much higher than it in group B (P = 0.001). Mean arterial blood pressure in group A was (67.0 +/- 9.1) mm Hg (1 mm Hg = 0.133 kPa), higher than group B (59.0 +/- 7.1) mm Hg (P = 0.009). There was no significant difference of CBF within procedure and neuropsychologic performance in both group as result.


CONCLUSIONS
For the patients presenting with carotid artery stenosis undergoing the procedure of CABG with CPB, increasing CPB flow volume could improve significantly diseased side cerebral blood flow and might reduce neurological complications.
Xu
Dong
D
Department of Heart, Xuanwu Hospital, Capital Medicine University, Beijing 100053, China.
Liu
Fei
F
Hua
Yang
Y
Zhang
Ke-feng
KF
Liu
Yan-hui
YH
Shang
Xue-bin
XB
Li
Hong-li
HL
Yao
Qing
Q
Li
Xue-feng
XF
Zhang
Rui
R
Li
Ya-qiong
YQ
D000368:Aged; D001921:Brain / Q000098:blood supply*; D002315:Cardiopulmonary Bypass / Q000379:methods*; D016893:Carotid Stenosis / Q000150:complications / Q000503:physiopathology*; D001026:Coronary Artery Bypass / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D011379:Prognosis; D012039:Regional Blood Flow; D016896:Treatment Outcome