Prognostic value of the immunohistochemistry correlation of Ki-67 and p53 in squamous cell carcinomas of the larynx.
Prognostic histological factors may contribute to determine the evolution of this neoplasia.


OBJECTIVE
To correlate p53 and Ki-67 immunohistochemical expression with age, histological degree, lymph node involvement and pathological staging in patients with laryngeal epidermoid carcinomas.


METHODS
We assessed thirty consecutive cases of laryngeal epidermoid carcinomas submitted to immunohistochemistry to check the expression of p53 e Ki-67 antibodies.


RESULTS
Mean age was of 56.2 years and the immunoexpression of the markers was observed in the group with more than 50 years of age, especially that o the ki-67 antibody (p=0.032). There was no relation between p53 and Ki-67 with lymph node involvement. Ki-67 was expressed in 70% of the high histology level cases and in 80% in the low histology ones; while p53 was of 70% only in the high level cases. Pathology staging showed that in the group of advanced carcinomas, p53 expression was of 61.5%, while Ki-67 proved positive for the early cases (100%) and advanced (73.1%).


CONCLUSIONS
There were no significant differences between p53 and Ki-67 immunoexpression in laryngeal epidermoid carcinoma, except in the group of patients with more than 50 years of age, when Ki-67 expression was significantly higher.
Rodrigues
Ricardo Boose
RB
Specialist in Pathology, MD, Pathologist, Pathology Service at Universidade Luterana do Brasil.
da Ros Motta
Rafael
R
Resident Pathologist at Universidade Luterana do Brasil.
Dos Santos Machado
Simone Márcia
SM
PhD student in the Pathology Graduate Program at FFFCMPA, Supervisor at the Medical Residency in Pathology at Universidade Luterana do Brasil.
Cambruzzi
Eduardo
E
PhD in Pathology at FFFCMPA, Adjunct Professor of Pathology in the Medicine Program at Universidade Luterana do Brasil.
Zettler
Eduardo Walker
EW
PhD in Medicine at UFRGS, Adjunct Professor of Pneumology in the Medicine Program at Universidade Luterana do Brasil.
Zettler
Claudio Galleano
CG
PhD in Pathology at FFFCMPA, Adjunct Professor of Pathology and Head of the Pathology Service at Universidade Luterana do Brasil.
Jotz
Geraldo Pereira
GP
PhD in Otorhinolaryngology, Head and Neck Surgery at UNIFESP. Post-PhD in Otorhinolaryngology at Pittsburgh University, Adjunct Professor and Head of the Otorhinolaryngology, Head and Neck Surgery Service at Universidade Luterana do Brasil. Adjunct Professor at the Department of Morphologic Sciences at UFRGS. Pathology Service - Universidade Luterana do Brasil.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53