title: p53 Codon 72 polymorphism is associated with occurrence of cervical carcinoma in the Chinese population.
abstract: We investigated the genotype distribution of the p53 Arg72Pro polymorphisms in 500 cervical carcinoma and 800 normal women in Chinese population. HPV infection rates in carcinoma patients and control were 89.4% and 31.0%. Women carrying the p53 Arg72Pro or p53 Pro72Pro increased the risk of cervical carcinoma (ORs and 95% CIs being 3.74 (2.65-5.30), 2.23 (1.49-3.34)). In HPV positive population, elevated risks were also associated with p53 Arg72Pro, Pro72Pro (ORs and 95% CIs being 3.83 (2.02-7.24), 2.38 (1.14-4.99)). These results suggest that a proline in position 72 of p53 increases the risk of cervical carcinoma in Chinese population.
authors: Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Rd #2, Hangzhou 310006, China.
authors: Feng
authors: F
authors: Ye
authors: Jing
authors: J
authors: Zhang
authors: Qi
authors: Q
authors: Cheng
authors: Jiajie
authors: J
authors: Shen
authors: Huaizeng
authors: H
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D003062:Codon; D005260:Female; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53