ACTH controls [(3)H]dopamine uptake in the adrenal chromaffin cell.
Effect of hypophysectomy on the disposition of [(3)H]dopamine-derived radioactivity in the mouse adrenal medulla was examined by autoradiography. Chromaffin cells, both A and NA type, incorporated less radioactivity in the hypophysectomized mice (50 days after operation) than in normal control mice: this decrease in the [(3)H]dopamine uptake was restored by intraperitoneal injection of ACTH (for 26 days; starting from 24th day after hypophysectomy; 40 mug/gbw/day). In the control mice chromaffin cells near the cortico-medullary junction showed a higher radioactivity than those in the center: hypophysectomy obscured this specific distribution pattern which reappeared after ACTH treatment.
Hirano
T
T
Departments of Physiology and Anatomy, Niigata University School of Medicin, Niigata Japan.
Kobayashi
S
S