title: Intra-arterial delivery of triolein emulsion increases vascular permeability in skeletal muscles of rabbits.
abstract: BACKGROUND
  To test the hypothesis that triolein emulsion will increase vascular permeability of skeletal muscle.
  
  
  METHODS
  Triolein emulsion was infused into the superficial femoral artery in rabbits (triolein group, n = 12). As a control, saline was infused (saline group, n = 18). Pre- and post-contrast T1-weighted MR images were obtained two hours after infusion. The MR images were qualitatively and quantitatively evaluated by assessing the contrast enhancement of the ipsilateral muscles. Histologic examination was performed in all rabbits.
  
  
  RESULTS
  The ipsilateral muscles of the rabbits in the triolein group showed contrast enhancement, as opposed to in the ipsilateral muscles of the rabbits in the saline group. The contrast enhancement of the lesions was statistically significant (p < 0.001). Histologic findings showed that most examination areas of the triolein and saline groups had a normal appearance.
  
  
  CONCLUSIONS
  Rabbit thigh muscle revealed significantly increased vascular permeability with triolein emulsion; this was clearly demonstrated on the postcontrast MR images.
authors: The Department of Radiology, Pusan National University College of Medicine, Medical Research Institute, Pusan National University, Pusan, South Korea. hakjink@pusan.ac.kr
authors: Hak Jin
authors: HJ
authors: Kim
authors: Yong Woo
authors: YW
authors: Kim
authors: In Sook
authors: IS
authors: Lee
authors: Jong Woon
authors: JW
authors: Song
authors: Yeon Joo
authors: YJ
authors: Jeong
authors: Seon Hee
authors: SH
authors: Choi
authors: Kyung Un
authors: KU
authors: Choi
authors: Kuen Tak
authors: KT
authors: Suh
authors: Byung Mann
authors: BM
authors: Cho
mesh_terms: D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D003287:Contrast Media; D004655:Emulsions; D007089:Image Enhancement; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging / Q000379:methods; D018482:Muscle, Skeletal / Q000098:blood supply*; D011817:Rabbits; D011897:Random Allocation; D012039:Regional Blood Flow; D014304:Triolein / Q000493:pharmacokinetics*
chemical_list: D003287:Contrast Media; D004655:Emulsions; D014304:Triolein