title: Mechanism of action of flavonoids as anti-inflammatory agents: a review.
abstract: Flavonoids are polyphenolic compounds that occur ubiquitously in plants having a variety of biological effects both in vitro and in vivo. They have been found to have antimicrobial, antiviral, anti-ulcerogenic, cytotoxic, anti-neoplastic, mutagenic, antioxidant, antihepatotoxic, antihypertensive, hypolipidemic, antiplatelet and anti-inflammatory activities. Flavonoids also have biochemical effects, which inhibit a number of enzymes such as aldose reductase, xanthine oxidase, phosphodiesterase, Ca(+2)-ATPase, lipoxygenase, cycloxygenase, etc. They also have a regulatory role on different hormones like estrogens, androgens and thyroid hormone. They have been found to have anti-inflammatory activity in both proliferative and exudative phases of inflammation. Several mechanisms of action have been proposed to explain anti-inflammatory action of flavonoids. The aim of the present review is to give an overview of the mechanism of action of potential anti-inflammatory flavonoids.
authors: PDM College of Pharmacy, Bahadurgarh, India. rathee_permender@rediffmail.com
authors: Permender
authors: P
authors: Rathee
authors: Hema
authors: H
authors: Chaudhary
authors: Sushila
authors: S
authors: Rathee
authors: Dharmender
authors: D
authors: Rathee
authors: Vikash
authors: V
authors: Kumar
authors: Kanchan
authors: K
authors: Kohli
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011494:Protein Kinases / Q000187:drug effects; D015533:Transcriptional Activation / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D018836:Inflammation Mediators; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D010727:Phosphoric Diester Hydrolases