title: Potential markers of preeclampsia--a review.
abstract: Preeclampsia is a leading cause of maternal and fetal/neonatal mortality and morbidity worldwide. The early identification of patients with an increased risk for preeclampsia is therefore one of the most important goals in obstetrics. The availability of highly sensitive and specific physiologic and biochemical markers would allow not only the detection of patients at risk but also permit a close surveillance, an exact diagnosis, timely intervention (e.g. lung maturation), as well as simplified recruitment for future studies looking at therapeutic medications and additional prospective markers. Today, several markers may offer the potential to be used, most likely in a combinatory analysis, as predictors or diagnostic tools. We present here the current knowledge on the biology of preeclampsia and review several biochemical markers which may be used to monitor preeclampsia in a future, that, we hope, is not to distant from today.
authors: Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Biomedicine, University Hospital of Basel, Basel, Switzerland. sgrill@uhbs.ch
authors: Simon
authors: S
authors: Grill
authors: Corinne
authors: C
authors: Rusterholz
authors: Rosanna
authors: R
authors: Zanetti-Dällenbach
authors: Sevgi
authors: S
authors: Tercanli
authors: Wolfgang
authors: W
authors: Holzgreve
authors: Sinuhe
authors: S
authors: Hahn
authors: Olav
authors: O
authors: Lapaire
mesh_terms: D051722:ADAM Proteins / Q000032:analysis; D000072199:ADAM12 Protein; D053607:Adrenomedullin / Q000032:analysis; D043925:Angiogenesis Inducing Agents / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D001158:Arteries / Q000000981:diagnostic imaging; D001323:Autoantibodies / Q000032:analysis; D015415:Biomarkers / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000032:analysis; D004247:DNA / Q000032:analysis; D000071063:Endoglin; D005260:Female; D005333:Fetus / Q000737:chemistry; D037161:Galectins / Q000032:analysis; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis; D054409:Nicotinamide Phosphoribosyltransferase / Q000032:analysis; D019007:P-Selectin / Q000032:analysis; D010920:Placenta / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000503:physiopathology; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis; D011296:Prenatal Diagnosis; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology; D011956:Receptors, Cell Surface / Q000032:analysis; D000683:Serum Amyloid P-Component / Q000032:analysis; D018608:Ultrasonography, Doppler; D014599:Uterus / Q000098:blood supply / Q000000981:diagnostic imaging; D000099153:Pentraxins
chemical_list: D051722:ADAM Proteins; D000072199:ADAM12 Protein; D053607:Adrenomedullin; D043925:Angiogenesis Inducing Agents; D015703:Antigens, CD; D001323:Autoantibodies; D015415:Biomarkers; D002097:C-Reactive Protein; D016207:Cytokines; D004247:DNA; D000071063:Endoglin; D037161:Galectins; D008565:Membrane Proteins; D054409:Nicotinamide Phosphoribosyltransferase; D019007:P-Selectin; D011257:Pregnancy Proteins; D011266:Pregnancy-Associated Plasma Protein-A; D044140:Receptor, Angiotensin, Type 1; D011956:Receptors, Cell Surface; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C064206:ENG protein, human; C038195:LGALS13 protein, human; C085455:nicotinamide phosphoribosyltransferase, human; C000606480:ADAM12 protein, human