title: Intragastric balloon for weight loss: results in 100 individuals followed for at least 2.5 years.
abstract: OBJECTIVE
  To determine long-term outcome after treatment with an intragastric balloon for 6 months, with no structured weight maintenance program offered after balloon removal.
  
  
  METHODS
  100 consecutive overweight/obese individuals (mean body mass index [BMI] 35.0 +/- 5.6 kg/m (2)) were prospectively followed after endoscopic implantation of a saline-filled intragastric balloon; 97 completed final follow-up at a mean of 4.8 +/- 1.6 years. Successful intragastric balloon therapy was defined as weight loss at 6 months of > or = 10 % of weight at baseline, that remained > or = 10 % until 2.5 years, without bariatric surgery. All analyses followed intention-to-treat principles.
  
  
  RESULTS
  At 6 months, mean weight loss was 12.6 +/- 8.3 kg, 63 individuals had > or = 10 % baseline weight loss; no severe morbidity was detected. During the first and second years following intragastric balloon removal, mean body mass increased by 4.2 +/- 6.8 and 2.3 +/- 6.0 kg, respectively ( P < 0.001 for both year-on-year comparisons). At 2.5 years, intragastric balloon therapy had been successful in 24 participants. At final follow-up (4.8 +/- 1.6 years), 28 had > or = 10 % baseline weight loss, 35 had undergone bariatric surgery (60 % had preoperative mass higher than baseline), and 3 were lost to follow-up; the 34 remaining had lost 1.5 +/- 5.8 kg compared with baseline. During follow-up, 13 had a second intragastric balloon implanted and 13 took sibutramine for short periods.
  
  
  CONCLUSIONS
  Intragastric balloon therapy was relatively innocuous and associated with successful weight loss and maintenance at 2.5 years in a quarter of participants. It represents a valid option for weight loss.
authors: Gastroenterology and Hepatology Service, Geneva University Hospitals, 1205 Geneva, Switzerland.
authors: Negrin S
authors: NS
authors: Dastis
authors: E
authors: E
authors: François
authors: J
authors: J
authors: Deviere
authors: A
authors: A
authors: Hittelet
authors: A
authors: A
authors: Ilah Mehdi
authors: M
authors: M
authors: Barea
authors: J-M
authors: JM
authors: Dumonceau
mesh_terms: D000328:Adult; D015992:Body Mass Index; D020878:Device Removal; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D015905:Gastric Balloon; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000628:therapy*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss