title: Evaluation of the prognostic significance of serum galectin-3 in American Joint Committee on Cancer stage III and stage IV melanoma patients.
abstract: Galectin-3 (Gal-3) is a member of the beta-galactoside-binding lectins family and has been implicated in angiogenesis, tumor invasion, and metastatic process in vitro and in vivo. As we showed recently that advanced melanoma patients presented high serum level of Gal-3, we investigated the association of this protein with the outcome of melanoma patients. Whether this protein could be a biomarker has not been assessed, and we compared the prognostic value of serum Gal-3 in multivariate analysis with lactate dehydrogenase, C-reactive protein and S100B. We conclude that Gal-3 could be of prognostic value in melanoma patients; more precisely, this protein has a strong independent prognostic signification with a cut-off value of 10 ng/ml. After these data, we believe that serum Gal-3 measurement can have an important role in the follow-up and management of advanced American Joint Commission on Cancer stage III and stage IV melanoma patients. Further studies will uncover whether Gal-3 will be able to open new therapeutic perspectives.
authors: Department of Dermatology, CHU-Brugmann, Erasme Hospital, Brussels, Belgium. pvereeck@ulb.ac.be
authors: Pierre
authors: P
authors: Vereecken
authors: Ahmad
authors: A
authors: Awada
authors: Stefan
authors: S
authors: Suciu
authors: Gilberto
authors: G
authors: Castro
authors: Renato
authors: R
authors: Morandini
authors: Anna
authors: A
authors: Litynska
authors: Danielle
authors: D
authors: Lienard
authors: Khaled
authors: K
authors: Ezzedine
authors: Ghanem
authors: G
authors: Ghanem
authors: Michel
authors: M
authors: Heenen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D037502:Galectin 3 / Q000097:blood*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008545:Melanoma / Q000097:blood* / Q000473:pathology / Q000556:secondary; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D009418:S100 Proteins / Q000097:blood; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D037502:Galectin 3; D009418:S100 Proteins; D002097:C-Reactive Protein