title: Describing commonalities in microbial effector delivery using the Gene Ontology.
abstract: Myriad symbiotic microbes, ranging from mutualistic through to pathogenic, deliver 'effector' molecules into the cytoplasm or cellular milieu of their hosts to facilitate colonization. Among ecologically and evolutionarily diverse taxa, analogous processes and structures exist to facilitate effector delivery. These include syringe-like injection (bacteria and nematodes), common host-targeting signals (oomycetes and protozoans) and specialized intercellular structures (fungi and oomycetes). Here, we briefly introduce readers to the Gene Ontology (GO), a controlled vocabulary to facilitate comparative genomics of diverse taxa. We also summarize and compare selected mechanisms of effector delivery from various organisms and show how careful annotation of gene products with GO can reveal underlying similarities among diverse taxa.
authors: Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors: Marcus C
authors: MC
authors: Chibucos
authors: Tsai-Tien
authors: TT
authors: Tseng
authors: João C
authors: JC
authors: Setubal
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D005658:Fungi / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology*; D009348:Nematoda / Q000235:genetics; D009868:Oomycetes / Q000235:genetics; D021381:Protein Transport; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism*; D018875:Vocabulary, Controlled
chemical_list: D026901:Membrane Transport Proteins; D037521:Virulence Factors