The effect of alpha-tocopherol in the acute ethanol intake and its withdrawal on penicillin-induced epilepsy.
The present study was designed to investigate the influence of acute ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in penicillin-induced epileptiform activity. Ethanol-treated rats received a daily dose of 3 g/kg or 9.0 g/kg of 30% ethanol solution for 3 days. Thirty minutes after penicillin injection (500 units, i.c.) the most effective dose of alpha-tocopherol (500 mg/kg) was administered intramuscularly (i.m.). Acute administration of ethanol, in a dose of 3 g/kg, did not change either frequency or amplitude of penicillin-induced epileptiform activity, while dose of 9 g/kg ethanol significantly decreased the mean frequency of penicillin-induced epileptiform ECoG activity in the ethanol-treated group. Ethanol (9 g/kg) withdrawal also caused an increase in the amplitude of epileptiform ECoG activity in the withdrawal group. The results suggest that acute administration of high dose ethanol (9 g/kg) and alpha-tocopherol have some limited anticonvulsive effects in penicillin-induced epileptiform activity in rats.
Kozan
Ramazan
R
Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis, 55139 Samsun, Turkey.
Ayyildiz
Mustafa
M
Yildirim
Mehmet
M
Agar
Erdal
E
D000428:Alcohol Drinking; D020270:Alcohol Withdrawal Seizures; D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology*; D000431:Ethanol / Q000009:adverse effects; D008297:Male; D010406:Penicillins; D051381:Rats; D017208:Rats, Wistar; D024502:alpha-Tocopherol / Q000494:pharmacology*
D000975:Antioxidants; D010406:Penicillins; D000431:Ethanol; D024502:alpha-Tocopherol