title: Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia.
abstract: Pneumonia caused by influenza A virus (IAV) can have devastating effects, resulting in respiratory failure and death. The idea that a new influenza pandemic might occur in the near future has triggered renewed interests in IAV infection. The receptor for advanced glycation end products (RAGE) is expressed on different cell types and plays a key role in diverse inflammatory processes. We here investigated the role of RAGE in the host response to IAV pneumonia using wild-type (wt) and RAGE deficient ((-/-)) mice. Whereas strong RAGE was constitutively expressed in the lungs of uninfected wt mice, in particular on endothelium, IAV pneumonia was associated with enhanced expression on endothelium and de novo expression on bronchial epithelium. Additionally, the high-affinity RAGE ligand high mobility group box 1 was upregulated during IAV pneumonia. RAGE(-/-) mice were relatively protected from IAV induced mortality and showed an improved viral clearance and enhanced cellular T cell response and activation of neutrophils. These data suggest that RAGE is detrimental during IAV pneumonia.
authors: Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. M.A.vanZoelen@amc.uva.nl
authors: Marieke A D
authors: MA
authors: van Zoelen
authors: Koenraad F
authors: KF
authors: van der Sluijs
authors: Ahmed
authors: A
authors: Achouiti
authors: Sandrine
authors: S
authors: Florquin
authors: Jennie M
authors: JM
authors: Braun-Pater
authors: Huan
authors: H
authors: Yang
authors: Peter P
authors: PP
authors: Nawroth
authors: Kevin J
authors: KJ
authors: Tracey
authors: Angelika
authors: A
authors: Bierhaus
authors: Tom
authors: T
authors: van der Poll
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000276:immunology; D004847:Epithelial Cells / Q000276:immunology; D020869:Gene Expression Profiling; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009504:Neutrophils / Q000276:immunology; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000473:pathology*; D011014:Pneumonia / Q000276:immunology / Q000473:pathology*; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000096:biosynthesis* / Q000172:deficiency; D016019:Survival Analysis; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic