In vitro evaluation of the antimicrobial activity of HM-242, a novel antiseptic compound.
The antimicrobial activities of N(4)-octyl-6,6-dimethyl-N(2)-(4-methylbenzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine (HM-242), a novel synthetic compound, were compared with those of chlorhexidine gluconate (CHG). HM-242 was a more potent microbicide than CHG in vitro; however, its minimal inhibitory concentrations were similar. In particular, HM-242 killed various Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, both efficiently and rapidly. HM-242 also showed potent virucidal activity against enveloped viruses such as influenza virus and herpes simplex virus. These characteristics suggest that HM-242 may well be useful as an antiseptic.
Okunishi
Junji
J
Department of Preclinical Development, Central Research Laboratories, Maruishi Pharmaceutical Co. Ltd, Osaka, Japan. junji_okunishi@maruishi-pharm.co.jp
Nishihara
Yutaka
Y
Maeda
Shirou
S
Ikeda
Masahiro
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009975:Orthomyxoviridae / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D000998:Antiviral Agents; C544878:N-octyl-6,6-dimethyl-N2-(4-methylbenzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine; D014227:Triazines; D014640:Vancomycin