Interpreting spatial information and regulating mitosis in response to spindle orientation.
The spindle position checkpoint (SPOC) is a regulatory mechanism that ensures accurate segregation of chromosomes in polarized cells during mitosis. In this issue of Genes & Development, Chan and Amon (pp. 1639-1649) identify a phosphoprotein phosphatase (Rts1-PP2A) as a new member of the checkpoint in budding yeast and define its role in interpreting spatial information during mitosis.
Burke
Daniel J
DJ
Department of Biochemistry and Molecular Genetics, University of Virginia Medical Center, Charlottesville, Virginia 22908, USA. dburke@virginia.edu
D018816:Genes, cdc / Q000502:physiology; D008780:Methyltransferases / Q000378:metabolism; D008938:Mitosis / Q000235:genetics*; D009687:Nuclear Proteins / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D054648:Protein Phosphatase 2 / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000254:growth & development; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D008941:Spindle Apparatus / Q000235:genetics* / Q000378:metabolism*
D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D008780:Methyltransferases; C403804:SPB1 protein, S cerevisiae; D011494:Protein Kinases; C503719:KIN4 kinase, S cerevisiae; D017346:Protein Serine-Threonine Kinases; D054648:Protein Phosphatase 2