title: Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder.
abstract: OBJECTIVE
  In the present study, we investigate the association between the val66met polymorphism of the brain-derived neurotrophic factor (BNDF) and the performance on the Wisconsin Card Sorting Test in a sample of Caucasian Brazilian patients with bipolar disorder.
  
  
  METHODS
  Sixty-four patients with bipolar disorder were assessed and their performance on the Wisconsin Card Sorting Test was compared with the allele frequency and genotype of the val66met polymorphism of the brain-derived neurotrophic factor.
  
  
  RESULTS
  The percentage of non-perseverative errors was significantly higher among patients with the val/val genotype. There was no association between (BNDF) genotype frequency and other Wisconsin Card Sorting Test domains.
  
  
  CONCLUSIONS
  Our results did not replicate previous descriptions of an association between a worse cognitive performance and the presence of the met allele of the val66met brain-derived neurotrophic factor gene polymorphism.
authors: Bipolar Disorder Program, Molecular Psychiatry Laboratory, INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors: Juliana Fernandes
authors: JF
authors: Tramontina
authors: Denise
authors: D
authors: Yates
authors: Pedro Vieira da Silva
authors: PV
authors: Magalhães
authors: Clarissa
authors: C
authors: Trentini
authors: Márcia Kauer
authors: MK
authors: Sant'anna
authors: Gabriel Rodrigo
authors: GR
authors: Fries
authors: Hugo
authors: H
authors: Bock
authors: Maria Luiza
authors: ML
authors: Saraiva-Pereira
authors: Flávio
authors: F
authors: Kapczinski
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D001938:Brazil / Q000453:epidemiology; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor