title: Preventive effect of a melon extract rich in superoxide scavenging activity on abdominal and liver fat and adipokine imbalance in high-fat-fed hamsters.
abstract: Studies showed that dietary antioxidants could be a therapy against obesity that is associated with a state of oxidative stress. Thus, this paper investigates whether a dietary ingredient, a melon juice extract rich in superoxide dismutase, would prevent the development of such obesity in hamsters. Five groups received a standard diet or a high-fat diet (HF) plus a daily gavage with water (control) or extract at 0.7, 2.8, or 5.6 mg/day. After 84 days, the higher dose lowered triglyceridemia (68%), production of liver superoxide anion (12%), mitochondrial cytochrome c oxidase activity (40%), lipid and protein oxidation products (35 and 35%, respectively), and leptinemia (99%) and increased adiponectinemia (29%), leading to a concomitant reduction in insulinemia (39%), insulin resistance (41%), and abdominal lipids (25%). The extract triggered a remarkable decrease of liver lipids (73%) and fully prevented the steatohepatitis induced by the HF diet. Chronic consumption of this melon extract may represent a new alternative to reduce obesity induced by a high-fat diet.
authors: UMR 204 Prévention des Malnutritions et des Pathologies Associées, Université Montpellier Sud de France, France.
authors: Kelly
authors: K
authors: Décordé
authors: Anta
authors: A
authors: Agne
authors: Dominique
authors: D
authors: Lacan
authors: Jeanne
authors: J
authors: Ramos
authors: Gilles
authors: G
authors: Fouret
authors: Emilie
authors: E
authors: Ventura
authors: Christine
authors: C
authors: Feillet-Coudray
authors: Jean-Paul
authors: JP
authors: Cristol
authors: Jean-Max
authors: JM
authors: Rouanet
mesh_terms: D050153:Abdominal Fat; D054392:Adipokines / Q000097:blood*; D000818:Animals; D006224:Cricetinae; D019662:Cucurbitaceae / Q000201:enzymology*; D004041:Dietary Fats / Q000008:administration & dosage*; D005234:Fatty Liver / Q000473:pathology / Q000517:prevention & control*; D005638:Fruit / Q000201:enzymology; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009765:Obesity / Q000517:prevention & control*; D018384:Oxidative Stress; D010936:Plant Extracts / Q000008:administration & dosage; D013482:Superoxide Dismutase / Q000008:administration & dosage*; D014280:Triglycerides / Q000097:blood
chemical_list: D054392:Adipokines; D004041:Dietary Fats; D008055:Lipids; D010936:Plant Extracts; D014280:Triglycerides; D013482:Superoxide Dismutase