title: Gain of chromosome arm 1q in patients in relapse and progression of multiple myeloma.
abstract: Abnormalities of chromosome 1 are among the most frequent chromosomal aberrations in patients with multiple myeloma (MM) and are considered a poor-risk genetic feature. To define the frequency and minimal region of 1q gain, we performed immunophenotyping and fluorescence in situ hybridization, comparative genomic hybridization (CGH), and array-CGH in 30 patients in relapse and progression of MM. Gain of 1q21 was found in 15 patients (50%), and in 14 of them whole-arm gain was found. One of these 14 patients had trisomy of chromosome 1 together with whole arm 1q gain, and two others had segmental duplication together with whole arm 1q gain. Segmental duplication of 1q21.1 approximately q23.1 alone was found in one patient. These results confirmed a high frequency of 1q aberrations and revealed that the vast majority of patients with 1q aberration in relapse and progression of MM display whole arm 1q gain. Finally, we observed that 1q gain is highly associated with number of additional changes.
authors: Department of Hemato-Oncology, Palacký University Hospital, I. P. Pavlova 6, Olomouc, Czech Republic. j.balcarkova@seznam.cz
authors: Jana
authors: J
authors: Balcárková
authors: Helena
authors: H
authors: Urbánková
authors: Vlastimil
authors: V
authors: Scudla
authors: Milena
authors: M
authors: Holzerová
authors: Jaroslav
authors: J
authors: Bacovský
authors: Karel
authors: K
authors: Indrák
authors: Marie
authors: M
authors: Jarosová
mesh_terms: D000328:Adult; D000368:Aged; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D055028:Comparative Genomic Hybridization; D018450:Disease Progression; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology*; D012008:Recurrence