Collagenous fibroma (desmoplastic fibroblastoma) with a new translocation involving 11q12: a case report.
Collagenous fibroma (or desmoplastic fibroblastoma) is a rare, benign tumor usually centered in the subcutaneous tissue composed of spindle-shaped to stellate fibroblasts and myofibroblasts in a densely collagenous background. Three previous case reports have described a t(2;11)(q31;q12) in this entity. Herein, we report a case of collagenous fibroma of deep soft tissue with t(11;17)(q12;p11.2). The breakpoint at chromosome 11q12 appears to be pathogenetic in this rare neoplasm.
Maghari
Amin
A
Department of Pathology and Laboratory Medicine, University Hospital, New Jersey Medical School, 150 Bergen Street, Newark, NJ 07103, USA. amin_maghari2002@yahoo.com
Ma
Naili
N
Aisner
Seena
S
Benevenia
Joseph
J
Hameed
Meera
M
D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D003094:Collagen / Q000378:metabolism*; D005260:Female; D005350:Fibroma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
D003094:Collagen