Prevalence of antiretroviral drug resistance in untreated persons newly diagnosed with HIV-1 infection.
Current knowledge of HIV-primary resistance indicates that the prevalence of transmitted resistant strains has increased to substantial levels over the past few years, with a wide variation depending upon a number of factors. New infections with a virus strain already resistant to antiretroviral drugs, namely non-nucleoside reverse transcriptase inhibitor (NNRTI), have a negative impact on initial treatment response and also shorten the time to first virologic failure. The aim of this study was to determine the prevalence of antiretroviral drug resistance by a genotypic test in a population with newly diagnosed HIV-1 infection at a clinical centre in Bologna between June 2006 and September 2007.
Biagetti
Carlo
C
Department of Digestive Apparatus Disease and Internal Medicine, Section of Infectious Diseases, "Alma Mater Studiorum", University of Bologna, S. Orsola Hospital, Bologna, Italy. biagetticarlo@libero.it
Bon
Isabella
I
Vitone
Francesca
F
Schiavone
Pasqua
P
Borderi
Marco
M
Pavoni
Michele
M
Verucchi
Gabriella
G
Re
Maria Carla
MC
Chiodo
Francesco
F
D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D024921:Drug Resistance, Multiple, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D015995:Prevalence; D012307:Risk Factors; D019562:Viral Load