Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature adult Ancylostoma caninum and Uncinaria stenocephala infections in dogs.
This paper reports the efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender tablets for dogs) against mature and immature adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) in dogs. The tablets were used at the minimum recommended dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. Four randomised, blinded and controlled laboratory studies demonstrated >95% efficacy against mature and immature adult stages of U. stenocephala and four randomised, blinded and controlled laboratory studies demonstrated >98% efficacy against mature and immature adult stages of A. caninum. No side effects of the treatment were observed. It is concluded that the emodepside plus praziquantel tablet is an effective and safe treatment against mature and immature hookworms.
Schimmel
Annette
A
Bayer Animal Health GmbH, Leverkusen, Germany.
Altreuther
Gertraut
G
Schroeder
Iris
I
Charles
Samuel
S
Cruthers
Larry
L
Ketzis
Jennifer
J
Kok
Dawid J
DJ
Kraemer
Friederike
F
McCall
John W
JW
Krieger
Klemens J
KJ
D000284:Administration, Oral; D000722:Ancylostoma / Q000187:drug effects*; D000723:Ancylostomatoidea / Q000187:drug effects*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D047630:Depsipeptides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004311:Double-Blind Method; D005243:Feces / Q000469:parasitology; D006725:Hookworm Infections / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count; D010919:Placebos / Q000008:administration & dosage; D011223:Praziquantel / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013607:Tablets / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
D000871:Anthelmintics; D047630:Depsipeptides; D010919:Placebos; D013607:Tablets; D011223:Praziquantel; C468987:emodepside