title: Characteristics and natural course of vertebral endplate signal (Modic) changes in the Danish general population.
abstract: BACKGROUND
  Vertebral endplate signal changes (VESC) are more common among patients with low back pain (LBP) and/or sciatica than in people who are not seeking care for back pain. The distribution and characteristics of VESC have been described in people from clinical and non-clinical populations. However, while the clinical course of VESC has been studied in patients, the natural course in the general population has not been reported. The objectives of this prospective observational study were to describe: 1) the distribution and characteristics of VESC in the lumbar spine, 2) its association with disc degeneration, and 3) its natural course from 40 to 44 years of age.
  
  
  METHODS
  Three-hundred-and-forty-four individuals (161 men and 183 women) sampled from the Danish general population had MRI at the age of 40 and again at the age of 44. The following MRI findings were evaluated using standardised evaluation protocols: type, location, and size of VESC, disc signal, and disc height. Characteristics and distribution of VESC were analysed by frequency tables. The association between VESC and disc degeneration was analysed by logistic regression analysis. The change in type and size of VESC was analysed by cross-tabulations of variables obtained at age 40 and 44 and tested using McNemar's test of symmetry.
  
  
  RESULTS
  Two-thirds (67%) of VESC found in this study were located in the lower part of the spine (L4-S1). VESC located at disc levels L1-L3 were generally small and located only in the anterior part of the vertebra, whereas those located at disc levels L4-S1 were more likely to extend further into the vertebra and along the endplate. Moreover, the more the VESC extended into the vertebra, the more likely it was that the adjacent disc was degenerated. The prevalence of endplate levels with VESC increased significantly from 6% to 9% from age 40 to 44. Again, VESC that was only observed in the endplate was more likely to come and go over the four-year period compared with those which extended further into the vertebra, where it generally persisted.
  
  
  CONCLUSIONS
  The prevalence of VESC increased significantly over the four-year period. Furthermore, the results from this study indicate that the distribution of VESC, its association with disc degeneration and its natural course, is dependent on the size of the signal changes.
authors: The Back Research Center, Ringe, Denmark. Tue.Secher.Jensen@shf.regionsyddanmark.dk
authors: Tue S
authors: TS
authors: Jensen
authors: Tom
authors: T
authors: Bendix
authors: Joan S
authors: JS
authors: Sorensen
authors: Claus
authors: C
authors: Manniche
authors: Lars
authors: L
authors: Korsholm
authors: Per
authors: P
authors: Kjaer
mesh_terms: D000328:Adult; D003718:Denmark; D018450:Disease Progression; D005260:Female; D006306:Health Surveys; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology*; D016015:Logistic Models; D008159:Lumbar Vertebrae / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D015588:Observer Variation; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D013122:Spinal Diseases / Q000473:pathology*; D013997:Time Factors