Influence of Indole-3-butyric acid on antioxidant defense systems in various tissues of rats at subacute and subchronic exposure.
This study was carried out to investigate the effects of Indole-3-butyric acid (IBA), a plant growth regulator (PGR), on antioxidant defense systems (ADS) such as reduced glutathione (GSH) level and Glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px) superoxide dismutase (SOD) enzymes activity in various tissues of rats exposed to 25 and 50 ppm dosages of IBA for 20 and 45 days. Results showed that the administrations of IBA fluctuated GSH levels in some tissues of rats treated with both dosages and periods. With regard to the ADS enzymes, SOD and GST activities increased significantly in the most of the tissues in rats treated with both dosages and periods of IBA. Also, GSH-Px activity fluctuated after subacute and subchronic exposure with both dosages in some of the tissues in rats compared to that the control rats. The observations presented led us to conclude that the administrations of IBA at subacute and subchronic affected the ADS system in various tissues of rats. This may reflect the potential role of these parameters as useful biomarkers for toxicity of IBA.
Topalca
Nuray
N
Department of Biology, Faculty of Science and Letters, Yuzuncu Yil University, 65080-Van, Turkey.
Yegin
Esref
E
Celik
Ismail
I
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010088:Oxidoreductases / Q000187:drug effects / Q000378:metabolism; D010937:Plant Growth Regulators / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D000975:Antioxidants; D007211:Indoles; D010937:Plant Growth Regulators; C014612:indolebutyric acid; D010088:Oxidoreductases; D005978:Glutathione