title: Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease.
abstract: OBJECTIVE
  Initial research has reported high levels of monocyte chemoattractant protein-1 (MCP-1) in gingival crevicular fluid (GCF) of periodontitis patients. Present study has been carried out to assess its concentration in serum and to find its association with periodontal health and disease.
  
  
  METHODS
  60 subjects were divided into three groups (n=20) based on gingival index (GI), probing pocket depth (PPD) and clinical attachment loss (CAL): healthy (group I), gingivitis (group II) and chronic periodontitis (group III). A fourth group (group IV) consisted of 20 subjects from group III, 6-8 weeks after treatment [i.e. scaling and root planing (SRP)]. Serum samples obtained from each patient were quantified for MCP-1 using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The mean MCP-1 concentration in serum was found to be the highest in group III i.e. 465.80 pg/ml and lowest in group I i.e. 155.20 pg/ml. For group II (251.60 pg/ml) and group IV (263.20 pg/ml) the mean MCP-1 concentrations were found to lie in between the concentrations obtained in group I and III.
  
  
  CONCLUSIONS
  Serum MCP-1 concentration was found to be, approximately one and half folds higher in gingivitis patients (group II) and three folds higher in chronic periodontitis patients (group III) as compared to healthy subjects (group I). Further, the MCP-1 concentration increased proportionally with the severity of disease in group II and III showing positive correlation with clinical parameters. Thus, its role as an inflammatory biomarker in periodontal disease can be proposed.
authors: Department of Periodontics, Government Dental College and Research Institute, Fort, Bangalore, Karnataka, India. periodontics_gdc@rediffmail.com
authors: A R
authors: AR
authors: Pradeep
authors: Happy
authors: H
authors: Daisy
authors: Parag
authors: P
authors: Hadge
mesh_terms: D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood*; D055113:Chronic Periodontitis / Q000097:blood / Q000276:immunology* / Q000628:therapy; D005260:Female; D005891:Gingivitis / Q000097:blood / Q000276:immunology*; D006801:Humans; D008297:Male; D010519:Periodontium / Q000276:immunology
chemical_list: D018932:Chemokine CCL2