title: Alkaline pH enhances farnesol production by Saccharomyces cerevisiae.
abstract: External environments affect prenyl alcohol production by squalene synthetase-deficient mutant Saccharomyces cerevisiae ATCC 64031. Cultivation of the yeast in medium with an initial pH ranging from 7.0 to 8.0 increased the amount of secreted farnesol (FOH). In contrast, acidic medium with a pH below 4.0 increased the intracellular FOH and its isomer nerolidol. These effects of alkaline pH were also observed on constant pH cultivation in a jar fermenter. On cultivation for 133 h, the FOH production reached 102.8 mg/l.
authors: Bio Research Lab., Toyota Motor Corporation, Toyota 471-8572, Japan.
authors: Masayoshi
authors: M
authors: Muramatsu
authors: Chikara
authors: C
authors: Ohto
authors: Shusei
authors: S
authors: Obata
authors: Eiji
authors: E
authors: Sakuradani
authors: Sakayu
authors: S
authors: Shimizu
mesh_terms: D003470:Culture Media; D005204:Farnesol / Q000378:metabolism*; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D012441:Saccharomyces cerevisiae / Q000378:metabolism*
chemical_list: D003470:Culture Media; D005204:Farnesol