title: Analysis of histopathological aspects in acquired middle ear cholesteatoma.
abstract: Middle ear cholesteatomas are characterized by the presence of stratified squamous epithelium in this cavity with highly invasive properties causing bone destruction and it may lead to complications.
  
  
  OBJECTIVE
  To study the histopathological features in acquired cholesteatomas of the middle ear, correlating this data with patient age.
  
  
  METHODS
  clinical and experimental cross-sectional study.
  
  
  METHODS
  Samples were obtained from 50 patients submitted to otologic surgery for the removal of middle ear cholesteatomas from 2006 to 2007. Thirty four patients were adults and 16 were children. Samples were studied by histological analysis.
  
  
  RESULTS
  We found the presence of epithelial atrophy (78%), epithelial acanthosis (88%), hyperplasia of the basal layer (88%) and formation of epithelial cones (62%). There was a positive and significant correlation between histopathological variables (such as epithelial acanthosis, hyperplasia of the basal layer and formation of epithelial cones). Histopathological variables presented no statistical significant difference in both age groups (p>0,05).
  
  
  CONCLUSIONS
  Cholesteatomas have hyperproliferating characteristics with epithelial acanthosis, hyperplasia of the basal layer and the presence of epithelial cones in the matrix.
authors: PhD student in Otorhinolaryngology at FCMSCSP, Professor and Instructor in the Department of Morphology at FCMSCSP.
authors: Adriana Leal
authors: AL
authors: Alves
authors: PhD in Medicine, Otorhinolaryngologist at FCMSCSP, Assistant Professor in the Department of Morphology at FCMSCSP.
authors: Celina Siqueira Barbosa
authors: CSB
authors: Pereira
authors: PhD in Medicine, Otorhinolaryngologist at UNIFESP - EPM, Adjunct Professor in the Department of Otorhinolaryngology at FCMSCSP.
authors: Fernando de Andrade Quintanilha
authors: FAQ
authors: Ribeiro
authors: PhD in Medicine, Oncologist at Fundação Antônio Prudente, Assistant Professor in the Department of Morphology at FCMSCSP; Send correspondence to: Adriana Leal Alves - R. Dr. João Clímaco Pereira 46 04532-070 SP SP. FAPESP.
authors: Jose Humberto Tavares Guerreiro
authors: JHTG
authors: Fregnani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018424:Cholesteatoma, Middle Ear / Q000473:pathology*; D003430:Cross-Sectional Studies; D004432:Ear, Middle / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult