title: [Manifestations of systemic mycoses and related infections in the central nervous system].
abstract: In daily practice mycotic infections of the CNS have become more and more frequent. The main causes are the wide-ranging use of corticosteroids, immunosuppressive, cytostatic drugs and antibiotics, the spreading of AIDS, the increasing number of surviving immature newborns. To illustrate the diagnostic difficulties, the authors report several cases.
  
  
  METHODS
  1. Multifocal hemorrhagic infarcts of the brain, caused by generalized aspergillosis in mantle cell malignant lymphoma. 2. Cerebral microabscesses, caused by systemic candidiasis in a premature infant. 3. Fatal actinomycosis, mimicking a space occupying tumour in the thigh and with an abscess in the brain, radiologically indicated as a metastasis. The cause of death was actinomycotic pneumonia. 4. A successfully treated and recovered patient with recurrent pneumonia and multiplex brain abscesses, caused by filamentous microorganism of a Nocardia species revealed by histological examination of the neurosurgical specimen.
  
  
  CONCLUSIONS
  We have to be aware for the development of the mycotic and related infections of endangered patients. Aspergillosis and candidiasis play the most significant role in the involvement of the central nervous system. Actinomycosis and nocardiosis are more sensitive to treatment, so their diagnosis is of life-saving importance. The therapeutic chances of high risk patients with aspergillosis and candidiasis will be definitively better, if the infection is recognized and appropriately treated before the involvement of the CNS.
authors: Vas Megyei Markusovszky Kórház Nonprofit Zrt. Patológiai Osztály Szombathely Markusovszky u. 3. 9700.
authors: Balázs
authors: B
authors: Tahin
authors: Justin
authors: J
authors: Cooke
authors: Magdolna
authors: M
authors: Grasselly
authors: János László
authors: JL
authors: Iványi
authors: Barna
authors: B
authors: Szima
authors: Mátyás
authors: M
authors: Bobest
authors: Erika
authors: E
authors: Ligeti
authors: Ferenc
authors: F
authors: Brittig
authors: Ferenc
authors: F
authors: Garzuly
authors: Csaba
authors: C
authors: Tóth
mesh_terms: D000196:Actinomycosis / Q000150:complications / Q000175:diagnosis*; D001921:Brain / Q000382:microbiology*; D001922:Brain Abscess / Q000382:microbiology; D002177:Candidiasis / Q000150:complications / Q000175:diagnosis*; D020314:Central Nervous System Fungal Infections / Q000175:diagnosis* / Q000382:microbiology*; D002543:Cerebral Hemorrhage / Q000382:microbiology; D002544:Cerebral Infarction / Q000382:microbiology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D020953:Neuroaspergillosis / Q000150:complications / Q000175:diagnosis*; D009617:Nocardia Infections / Q000175:diagnosis*