Mitomycin-C as adjuvant therapy in the treatment of sebaceous gland carcinoma in high-risk locations.
OBJECTIVE
To report on the use of Mitomycin-C as adjuvant therapy to excision and cryotherapy in patients with sebaceous gland carcinoma (SGC) in high-risk locations.


METHODS
Retrospective, consecutive, case series.


METHODS
Three patients with SGC of the upper palpebral conjunctiva or caruncle, but without clinical pagetoid spread.


METHODS
Following excision and double freeze-thaw cryotherapy, patients with histology demonstrating SGC of the ocular surface were treated with topical Mitomycin-C (0.04%). Follow-up was conducted over an average of 30 months (range: 24-37 months).


METHODS
Postoperative evidence of local recurrence, lymph node or distant organ metastasis.


RESULTS
No patients had evidence of local recurrence or systemic disease.


CONCLUSIONS
Wide surgical excision with cryotherapy is the basis of treatment of SGC without pagetoid spread. The use of Mitomycin-C as adjuvant therapy remains controversial, although there is some rationale for its use in high-risk situations.
Rudkin
Adam K
AK
Department of Ophthalmology, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia. adam@rudkin.com.au
Muecke
James S
JS
D018266:Adenocarcinoma, Sebaceous / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003230:Conjunctival Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D017679:Cryotherapy; D005260:Female; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D012189:Retrospective Studies; D012626:Sebaceous Gland Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin