title: Treatment of acute intravascular thrombi with diagnostic ultrasound and intravenous microbubbles.
abstract: The purpose of this study was to determine whether high mechanical index (MI) impulses from diagnostic ultrasound (DUS) could dissolve intravascular thrombi using intravenous microbubbles. Using a canine model, DUS was applied during a continuous intravenous infusion of microbubbles. Completely thrombosed grafts were assigned to 2 treatment regimens: low-MI (<0.5-MI) ultrasound alone; or intermittent high-MI impulses (1.9-MI) guided by low-MI ultrasound (contrast pulse sequencing). A 20-MHz cavitation detector was placed confocal to the ultrasound transducer to make intravascular cavitation measurements in 1 dog. Intravascular cavitational activity was detected when an MI of >0.5 was applied. In grafts treated with intermittent high-MI ultrasound, angiographic success was 71% at 30 min and 79% at 45 min, compared with 20% and 30% at these times in the low-MI ultrasound alone group (p < 0.05). We conclude that a commercially available DUS transducer can successfully recanalize acute intravascular thrombi during a continuous microbubble infusion.
authors: Department of Internal Medicine/Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198-2265, USA.
authors: Feng
authors: F
authors: Xie
authors: John
authors: J
authors: Lof
authors: Carr
authors: C
authors: Everbach
authors: Anming
authors: A
authors: He
authors: Richard M
authors: RM
authors: Bennett
authors: Terry
authors: T
authors: Matsunaga
authors: Jason
authors: J
authors: Johanning
authors: Thomas R
authors: TR
authors: Porter
mesh_terms: D000208:Acute Disease; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004285:Dogs; D004867:Equipment Design; D005466:Fluorocarbons / Q000008:administration & dosage*; D005740:Gases; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000628:therapy*; D007262:Infusions, Intravenous; D045423:Microbubbles; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000628:therapy*; D013997:Time Factors; D014160:Transducers, Pressure; D014464:Ultrasonic Therapy / Q000295:instrumentation; D018084:Ultrasonography, Interventional / Q000295:instrumentation
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; D005740:Gases