Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance.
MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer.
Zhang
Yuanyuan
Y
Ningbo University School of Medicine, 315211, Ningbo, China.
Guo
Junming
J
Li
Dong
D
Xiao
Bingxiu
B
Miao
Ying
Y
Jiang
Zhen
Z
Zhuo
Hui
H
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001940:Breast / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000097:blood; D002277:Carcinoma / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D003106:Colon / Q000378:metabolism; D003199:Computer Systems; D015536:Down-Regulation; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008168:Lung / Q000378:metabolism; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D008875:Middle Aged; D009928:Organ Specificity; D011237:Predictive Value of Tests; D012334:RNA, Neoplasm / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000378:metabolism
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; C534612:MIRN31 microRNA, human; D035683:MicroRNAs; D012334:RNA, Neoplasm