miRNAs: from biogenesis to networks.
In eukaryotes, besides alternative splicing and promoter regulation of "classical" genes, there is also another level of genetic regulation based on non-coding RNAs (ncRNAs). The most famous group of ncRNAs is microRNAs, probably the biggest number of genome regulators. Here, we summarize the knowledge that has been accumulated about the microRNA field, focusing our attention on brief history, biogenesis, regulated mechanism, computational methods of miRNA finding and miRNA target sites, miRNAs and diseases, and miRNAs and network analysis.
Russo
Giuseppe
G
Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA.
Giordano
Antonio
A
D000818:Animals; D001185:Artificial Intelligence; D001665:Binding Sites; D003198:Computer Simulation; D005786:Gene Expression Regulation; D006801:Humans; D053858:Metabolic Networks and Pathways; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics; D012984:Software; D049490:Systems Biology / Q000379:methods*
D035683:MicroRNAs