title: Correlation of ischemic area and coronary flow with ameroid size in a porcine model.
abstract: BACKGROUND
  Ameroid constriction has long been used to induce chronic hibernating myocardium in animal models.
  
  
  METHODS
  Thirty-six pigs underwent surgical implantation of an ameroid constrictor around their left circumflex (LCx) coronary artery. The device had an internal diameter of 2.25 (n=9), 2.50 (n=16), or 2.75 (n=11) mm. Thrombolysis in Myocardial Infarction (TIMI) grade coronary flow was assessed angiographically during device placement and on postoperative d 30. The ischemic and total left ventricular (LV) areas were measured with endocardial voltage mapping (NOGA) on d 30.
  
  
  RESULTS
  For ameroid constrictor diameters of 2.25, 2.50, and 2.75 mm, the ratio of the ischemic area versus the total LV area averaged 24% ± 10%, 21% ± 6%, and 23% ± 9%, respectively (P=NS). Coronary angiography revealed complete LCx occlusion in all animals. TIMI grade-1 flow was the statistical mode for all groups and was independent of constrictor diameter. Normalization of the device diameter with the vessel diameter did not affect the statistical results.
  
  
  CONCLUSIONS
  For the range of ameroid constrictor sizes evaluated in this study, coronary flow and the ischemic LV area were independent of device size. The ischemic area and coronary flow created by ameroid constrictor placement were highly homogeneous and accurate for an experimental model of hibernating myocardium.
authors: Cardiovascular Surgical Research Laboratories, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas 77030, USA. etuzun@heart.thi.tmc.edu
authors: Egemen
authors: E
authors: Tuzun
authors: Eddie
authors: E
authors: Oliveira
authors: Cuneyt
authors: C
authors: Narin
authors: Hassan
authors: H
authors: Khalil
authors: Pilar
authors: P
authors: Jimenez-Quevedo
authors: Emerson
authors: E
authors: Perin
authors: Guilherme
authors: G
authors: Silva
mesh_terms: D000818:Animals; D002364:Caseins; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000473:pathology; D004195:Disease Models, Animal; D020100:Hydrogels; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D017682:Myocardial Stunning / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D012720:Severity of Illness Index; D013552:Swine
chemical_list: D002364:Caseins; D020100:Hydrogels; C009719:ameroid