Colloidal polymeric nanoparticles and brain drug delivery.
The blood brain barrier protects the brain from harmful substances in the blood stream and has stopped the development of many powerful and interesting drugs candidates for central nervous system due to the low poor distribution and by efflux mechanisms. Many different approaches have been developed in order to overcome this barrier and the drug gain access to the brain. The polymeric nanoparticles are efficient colloidal systems that have been investigated to the brain drug delivery. This review will focus on the current strategies for brain drug delivery emphasizing the properties and characteristics of polymeric nanoparticles for this purpose.
Khalil
Najeh Maissar
NM
Departamento de Farmácia - Universidade Estadual do Centro-Oeste / UNICENTRO - Guarapuava, Brasil.
Mainardes
Rubiana Mara
RM
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology; D001927:Brain Diseases / Q000188:drug therapy*; D003102:Colloids; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry
D003102:Colloids; D004364:Pharmaceutical Preparations; D011108:Polymers