title: Secondary amine formation from reductive amination of carbonyl compounds promoted by Lewis acid using the InCl3/Et3SiH system.
abstract: A robust and reliable method has been developed for reductive amination of primary amines with various aldehydes and ketones using Zn(ClO(4))(2) x 6 H(2)O as a catalyst. [In-H] generated in situ via a combination of InCl(3) and Et(3)SiH is employed as an effective reducing system. A variety of secondary amines can be synthesized in a one-pot procedure in excellent yields.
authors: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
authors: On-Yi
authors: OY
authors: Lee
authors: Ka-Lun
authors: KL
authors: Law
authors: Dan
authors: D
authors: Yang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D007204:Indium / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000588:Amines; D007659:Ketones; D017967:Zinc Compounds; D007204:Indium; C020758:indium trichloride