Chlamydia pneumoniae and atherosclerosis: the role of mast cells.
Chlamydia pneumoniae (C. pneumoniae), a respiratory pathogen, has been implicated in the pathogenesis of atherosclerosis, an inflammatory progressive disease, characterized by the formation of atherosclerotic plaques. Among several types of inflammatory cells involved in the atherogenesis process, recently particular attention has been directed toward the mast cells. Experimental studies have provided several mechanisms by which C. pneumoniae and mast cells could play a role in all stages of atherosclerosis, from initial inflammatory lesions to plaque rupture. C. pneumoniae, as well as mast cells, may actively participate both through the production of cytokines and matrix-degrading metalloproteinases and by provoking apoptosis of atheroma-associated vascular cells, key events in plaque rupture. This mini-review provides a brief overview on adventitial inflammatory effects of C. pneumoniae and mast cells and their potential role in plaque instability. In addition, in this paper we review the role of mast cells in innate immunity.
Di Pietro
M
M
Department of Public Health Sciences, Sapienza University, Rome, Italy.
Schiavoni
G
G
Del Piano
M
M
Shaik
Y
Y
Boscolo
P
P
Caraffa
A
A
Grano
M
M
Teté
S
S
Conti
F
F
Sessa
R
R
D050197:Atherosclerosis / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D002690:Chlamydia Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D016993:Chlamydophila pneumoniae / Q000472:pathogenicity*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000150:complications / Q000276:immunology / Q000473:pathology; D008407:Mast Cells / Q000276:immunology / Q000473:pathology*