title: Are abnormal premorbid personality traits associated with Alzheimer's disease? - A case-control study.
abstract: OBJECTIVE
  To examine the association between premorbid personality traits, social networks and AD, using a case-control design, and two informant-based retrospective assessments of premorbid personality.
  
  
  METHODS
  Cases consisted of 217 Subjects diagnosed with probable late onset Alzheimer's disease (160 females and 57 males). Recruitment was from both community and nursing home settings. Controls consisted of 76 unaffected siblings (44 females and 32 males) of patients with AD. Both cases and controls received informant ratings of premorbid personality.
  
  
  RESULTS
  A selection of abnormal personality traits were over represented in the AD group. AD was particularly associated with Cluster A personality disorder traits (Paranoid, Schizoid, Schizotypal). AD cases had correspondingly sparser social networks.
  
  
  CONCLUSIONS
  There is an association between abnormal personality traits and AD. Individuals with AD also appear to have had lower levels of social interactivity.
authors: Department of Old Age Psychiatry, Farnham Road Hospital, Guildford, Surrey, UK. helennic@hotmail.com
authors: Helen
authors: H
authors: Nicholas
authors: Paul
authors: P
authors: Moran
authors: Catherine
authors: C
authors: Foy
authors: Richard G
authors: RG
authors: Brown
authors: Simon
authors: S
authors: Lovestone
authors: Stephanie
authors: S
authors: Bryant
authors: Harry
authors: H
authors: Boothby
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010551:Personality; D010554:Personality Disorders / Q000523:psychology*; D012189:Retrospective Studies; D012919:Social Behavior; D012944:Social Support; D011795:Surveys and Questionnaires