title: Prediction of efficacy of anti-TNF biologic agent, infliximab, for rheumatoid arthritis patients using a comprehensive transcriptome analysis of white blood cells.
abstract: Introduction of biologics, such as infliximab, to the therapy of rheumatoid arthritis (RA) patients has revolutionized the treatment of this disease. However, biomarkers for predicting the efficacy of the drug at an early phase of treatment for selecting real responders have not been found. We here present predictive markers based on a thorough transcriptome analysis of white blood cells from RA patients. RNA from whole blood cells of consecutive 42 patients before the first infusion was analyzed with microarrays for training studies. Samples from the subsequent 26 consecutive patients were used for a prospective study. We categorized the results into no inflammation and residual inflammation groups using the serum C-reactive protein (CRP) level at 14weeks after the first infusion. The accuracy of prediction in our study was 65.4%.
authors: DNA Chip Research Inc, Yokohama 230-0045, Japan.
authors: Motohiko
authors: M
authors: Tanino
authors: Ryo
authors: R
authors: Matoba
authors: Seiji
authors: S
authors: Nakamura
authors: Hideto
authors: H
authors: Kameda
authors: Kouichi
authors: K
authors: Amano
authors: Toshitsugu
authors: T
authors: Okayama
authors: Hayato
authors: H
authors: Nagasawa
authors: Katsuya
authors: K
authors: Suzuki
authors: Kenichi
authors: K
authors: Matsubara
authors: Tsutomu
authors: T
authors: Takeuchi
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology* / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000235:genetics*; D002097:C-Reactive Protein / Q000032:analysis; D015870:Gene Expression / Q000187:drug effects; D020869:Gene Expression Profiling; D006801:Humans; D000069285:Infliximab; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D000069285:Infliximab