title: Symplastic glomus tumor - a rare but distinct benign histological variant with analogy to other 'ancient' benign skin neoplasms.
abstract: A 78-year-old woman presented with a nail deformity of the index finger of the left hand associated with paroxysmal pain upon cold exposure. Histologically, a well-circumscribed tumor of 3 mm diameter was found in the dermis. The neoplastic cells in some areas were of pronouncedly variable size and cytomorphology, mostly epithelioid in shape, with eosinophilic cytoplasm and indistinctly defined cell borders. Pronounced nuclear pleomorphism and atypia were striking features, but no mitotic figures were noted. Multinuclear cells were present as were numerous small-to-medium vessels throughout the tumor. The tumor stroma showed myxoid areas. Immunohistochemistry showed cytoplasmic and membranous expression of smooth muscle actin and vimentin. The histological features and immunoprofile were consistent with the diagnosis of symplastic glomus tumor, a rare histological variant, which has been defined as a glomus tumor exhibiting marked nuclear atypia, in the absence of any other criteria for malignancy. The biological behavior of the tumor is benign. It is essential to differentiate this entity from malignant glomus tumor, which has metastatic potential. Even prominent cellular atypia and nuclear pleomorphism in a glomus tumor as in our case is not a marker of malignancy in the absence of additional criteria.
authors: Department of Dermatology, University Hospital, Zurich, Switzerland. jivko.kamarachev@usz.ch
authors: Jivko
authors: J
authors: Kamarashev
authors: Lars E
authors: LE
authors: French
authors: Reinhard
authors: R
authors: Dummer
authors: Katrin
authors: K
authors: Kerl
mesh_terms: D000368:Aged; D005260:Female; D005385:Fingers / Q000473:pathology*; D005918:Glomus Tumor / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*