Post-cholecystectomy quality of life: a prospective multicenter cohort study of its associations with preoperative functional status and patient demographics.
OBJECTIVE
This study analyzed patient demographics and preoperative functional status for associations with post-cholecystectomy quality of life (QOL).


METHODS
This prospective study analyzed 159 cholecystectomy patients at two tertiary academic hospitals. All patients completed the SF-36 and the gastrointestinal quality of life index (GIQLI) at baseline and at 3 and 6 months postoperatively. The 95% confidence intervals for differences in responsiveness estimates were derived by bootstrap estimation. Scores derived by these instruments were interpreted by generalized estimating equation (GEE) before and after cholecystectomy.


RESULTS
The examined population significantly (p < 0.05) improved in both SF-36 subscales and GIQLI subscales. After adjusting for time effects (time, and time(2)) and baseline predictors, GEE approaches revealed the following explanatory variables for QOL: time, time(2), age, gender, preoperative GIQLI score, body mass index, and number of comorbidities.


CONCLUSIONS
The data revealed dramatically improved post-cholecystectomy QOL. However, QOL change was simultaneously associated with preoperative functional status and demographic characteristics.
Shi
Hon-Yi
HY
Graduate Institute of Healthcare Administration, Kaohsiung Medical University, Kaohsiung, Taiwan.
Lee
King-Teh
KT
Lee
Hao-Hsien
HH
Uen
Yih-Huei
YH
Tsai
Jinn-Tsong
JT
Chiu
Chong-Chi
CC
D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D002763:Cholecystectomy / Q000379:methods* / Q000523:psychology*; D017081:Cholecystectomy, Laparoscopic / Q000379:methods / Q000523:psychology; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications / Q000453:epidemiology; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011446:Prospective Studies; D011788:Quality of Life; D012086:Reoperation; D018570:Risk Assessment; D012737:Sex Factors; D018434:Sickness Impact Profile