title: Severe early onset hemolysis, elevated liver enzyme, and low platelet-syndrome in 2 subsequent pregnancies: case report and review of the literature.
abstract: BACKGROUND
  Pregnancies after a previous pregnancy complicated by hemolysis, elevated liver enzyme, and low platelet (HELLP) syndrome carry an increased risk of HELLP-syndrome.
  
  
  METHODS
  We report on a 35-year-old patient with both HELLP-syndrome and fatal neonatal outcome in two subsequent pregnancies with delivery by cesarean section in the 26th and 27th gestational weeks, respectively. The children were immediately admitted to the neonatal intensive care unit but died in their postpartum period. Before the second pregnancy testing for antiphospholipid-syndrome revealed normal results.
  
  
  CONCLUSIONS
  In general, pregnancies after HELLP-syndrome carry increased risks for pregnancy-related complications. Evaluation of the immunologic status and application of immune-globulins could be diagnostic and therapeutic options in our case. Further research is recommended to evaluate the mechanisms of recurrence of HELLP-syndrome.
authors: Department of Obstetrics and Gynecology, Medical University Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. johannes.ott@meduniwien.ac.at
authors: Johannes
authors: J
authors: Ott
authors: Gunda
authors: G
authors: Poschalko
authors: Harald
authors: H
authors: Zeisler
mesh_terms: D000328:Adult; D002585:Cesarean Section; D017809:Fatal Outcome; D005260:Female; D017359:HELLP Syndrome / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012008:Recurrence