Genomic and Proteomic Biomarker Discovery in Neurological Disease.
Technology for high-throughout scanning of the human genome and its encoded proteins have rapidly developed to allow systematic analyses of human disease. Application of these technologies is becoming an increasingly effective approach for identifying the biological basis of genetically complex neurological diseases. This review will highlight significant findings resulting from the use of a multitude of genomic and proteomic technologies toward biomarker discovery in neurological disorders. Though substantial discoveries have been made, there is clearly significant promise and potential remaining to be fully realized through increasing use of and further development of -omic technologies.
Robeson
Rilee H
RH
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona 85004.
Siegel
Andrew M
AM
Dunckley
Travis
T