Uncommon clinical pattern of FMF: protracted febrile myalgia syndrome.
Familial Mediterranean fever (FMF) is a genetic multisystem disorder of unknown etiology characterized by recurrent episodes of fever and pain due to acute inflammation of the peritoneum, synovia, or pleura. Up to 25% of patients with FMF report muscle pain. Myalgia may be a spontaneous pattern, exercise-induced pattern, or protracted febrile myalgia syndrome (PFMS). PFMS is characterized by severe paralyzing myalgia, high fever, abdominal pain, diarrhea, arthritis/arthralgia, and transient vasculitic rashes mimicking Henoch-Schonlein purpura. The episodes last for 4-6 weeks, except in those patients treated with corticosteroids. The PFMS may recur even under colchicine prophylaxis. We describe a 30-year-old pregnant Turkish woman with known FMF and under colchicine prophylaxis, with severe myalgia for 8 weeks, emphasizing the importance of a different clinical pattern of PFMS even in the absence of other symptoms.
Tufan
Gülnihal
G
Department of Internal Medicine, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey. gntufan@yahoo.com
Demir
Serap
S
D000328:Adult; D003078:Colchicine / Q000627:therapeutic use; D010505:Familial Mediterranean Fever / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005334:Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D009135:Muscular Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D011247:Pregnancy; D013577:Syndrome; D016896:Treatment Outcome
D003078:Colchicine