title: Gene expression of adrenomedullin in canine normal tissues and diseased hearts.
abstract: The purposes of this study were to determine the tissue distribution of canine adrenomedullin (AM) and to determine whether increased canine AM mRNA expression is associated with congestive heart failure (CHF) due to mitral regurgitation (MR). Canine AM mRNA expression was detectable in various normal tissues, including cardiovascular tissues. In addition, the AM mRNA expression in the left atrium of dogs with MR was significantly higher than that in normal subjects. In conclusion, AM is a potential neurohumoral factor in dogs with CHF due to MR.
authors: Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Japan.
authors: Nobuyuki
authors: N
authors: Kanno
authors: Kazushi
authors: K
authors: Asano
authors: Kenji
authors: K
authors: Teshima
authors: Kenji
authors: K
authors: Kutara
authors: Mamiko
authors: M
authors: Seki
authors: Kazuya
authors: K
authors: Edamura
authors: Rui
authors: R
authors: Kano
authors: Atsuhiko
authors: A
authors: Hasegawa
authors: Shigeo
authors: S
authors: Tanaka
mesh_terms: D053607:Adrenomedullin / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics* / Q000378:metabolism; D004285:Dogs; D015870:Gene Expression; D006333:Heart Failure / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D009206:Myocardium / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D018709:Statistics, Nonparametric
chemical_list: D012333:RNA, Messenger; D020097:Natriuretic Peptide, Brain; D053607:Adrenomedullin; D009320:Atrial Natriuretic Factor