Palladium-catalyzed decarboxylative arylation of C-H bonds by aryl acylperoxides.
A Pd(OAc)(2)-catalyzed protocol for decarboxylative arylation of aromatic C-H bond was developed using aryl acylperoxides as inexpensive aryl sources. Substrates containing pyridyl, oxime, and oxazoline groups undergo effectively ortho-selective C-H arylation with excellent functional group tolerance. This arylation should begin by directing-group-assisted cyclopalladation, followed by the reaction of the palladacycle with aryl radicals generated in situ by thermal decomposition of the peroxides.
Yu
Wing-Yiu
WY
Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and the Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. bcwyyu@inet.polyu.edu.hk
Sit
Wing Nga
WN
Zhou
Zhongyuan
Z
Chan
Albert S-C
AS
D001585:Benzoyl Peroxide / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D006860:Hydrogen Bonding; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D009942:Organometallic Compounds; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; D001585:Benzoyl Peroxide