Chemical constituents of Dracocephalum forrestii.
A systematic phytochemical examination of the whole plant Dracocephalum forrestii led to the isolation of 4 new and 65 known chemical constituents. By detailed 1D and 2D NMR spectroscopic analyses, the new compounds were identified as 4-hydroxy-3-methoxyphenylethanol 8- O-[(6- O-syringoyl)- beta- D-glucopyranoside] (1), 3,4,5-trimethoxyphenylethanol beta- D-glucopyranoside ( 2), 4- O-[ beta- D-glucopyranosyl-(1 --> 3)- alpha- L-rhamnopyranosyl]phenylethylcinnamamide (3), and 9''- O- N-butyl lithospermate (4). The new isolates were evaluated for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Compound 2 revealed a moderate effect without any cytotoxicity under the assayed concentrations.
Li
Su-Mei
SM
Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
Yang
Xian-Wen
XW
Li
Yong-Li
YL
Shen
Yun-Heng
YH
Feng
Lin
L
Wang
Yue-Hu
YH
Zeng
Hua-Wu
HW
Liu
Xiao-Hua
XH
Zhang
Chang-Sheng
CS
Long
Chun-Lin
CL
Zhang
Wei-Dong
WD
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019686:Lamiaceae / Q000737:chemistry*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
C548764:4-O-(beta-D-glucopyranosyl-(1- 3)-alpha-L-rhamnopyranosyl)phenylethylcinnamamide; C548762:4-hydroxy-3-methoxyphenylethanol 8-O-((6-O-syringoyl)-beta-D-glucopyranoside); D000893:Anti-Inflammatory Agents; D002934:Cinnamates; D005960:Glucosides; D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide