title: Wild birds of declining European species are dying from a thiamine deficiency syndrome.
abstract: Wild birds of several species are dying in large numbers from an idiopathic paralytic disease in the Baltic Sea area. Here, we demonstrate strong relationships between this disease, breeding failure, and thiamine (vitamin B(1)) deficiency in eggs, pulli, and full-grown individuals. Thiamine is essential for vertebrates, and its diphosphorylated form functions as a cofactor for several life sustaining enzymes, whereas the triphosphorylated form is necessary for the functioning of neuronal membranes. Paralyzed individuals were remedied by thiamine treatment. Moreover, thiamine deficiency and detrimental effects on thiamine-dependent enzymes were demonstrated in the yolk, liver, and brain. We propose that the mortality and breeding failure are part of a thiamine deficiency syndrome, which may have contributed significantly to declines in many bird populations during the last decades.
authors: Department of Applied Environmental Science, Stockholm University, SE-106 91 Stockholm, Sweden. lennart.balk@itm.su.se
authors: Lennart
authors: L
authors: Balk
authors: Per-Ake
authors: PA
authors: Hägerroth
authors: Gun
authors: G
authors: Akerman
authors: Marsha
authors: M
authors: Hanson
authors: Ulla
authors: U
authors: Tjärnlund
authors: Tomas
authors: T
authors: Hansson
authors: Gunnar Thor
authors: GT
authors: Hallgrimsson
authors: Yngve
authors: Y
authors: Zebühr
authors: Dag
authors: D
authors: Broman
authors: Torsten
authors: T
authors: Mörner
authors: Henrik
authors: H
authors: Sundberg
mesh_terms: D000818:Animals; D000835:Animals, Wild; D001715:Bird Diseases / Q000401:mortality* / Q000473:pathology; D001717:Birds; D046091:Charadriiformes; D005060:Europe; D053476:Extinction, Biological; D005843:Geography; D010243:Paralysis / Q000473:pathology; D013045:Species Specificity; D046749:Starlings; D013577:Syndrome; D013832:Thiamine Deficiency / Q000401:mortality / Q000473:pathology / Q000662:veterinary*