title: Oxidative stress, thermogenesis and evolution of uncoupling proteins.
abstract: The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic mechanism. Recent work published in BMC Evolutionary Biology, following the identification of UCP1 orthologs in non-eutherians, concludes that this unique function appeared after sequence divergence and purifying selection that allowed functional co-option.
authors: Centro de Investigaciones Biológicas, CSIC, Madrid, Spain. rial@cib.csic.es
authors: Eduardo
authors: E
authors: Rial
authors: Rafael
authors: R
authors: Zardoya
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D007473:Ion Channels / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics*; D005810:Multigene Family; D018384:Oxidative Stress; D010802:Phylogeny; D022722:Thermogenesis; D000071256:Uncoupling Protein 1
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; D000071256:Uncoupling Protein 1