title: Brief depression screening with the PHQ-2 associated with prognosis following percutaneous coronary intervention with paclitaxel-eluting stenting.
abstract: BACKGROUND
  Depression is associated with adverse prognosis in cardiac patients, warranting the availability of brief and valid instruments to identify depressed patients in clinical practice.
  
  
  OBJECTIVE
  We examined whether the two-item Patient Health Questionnaire (PHQ-2) was associated with adverse events in percutaneous coronary intervention (PCI) patients treated with paclitaxel-eluting stenting (using the continuous score and various cutoffs), overall and by gender.
  
  
  METHODS
  Prospective follow-up study.
  
  
  METHODS
  Consecutive PCI patients (n = 796) seen at a university medical centre.
  
  
  METHODS
  PHQ-2 at baseline. The study endpoint was an adverse event, defined as a combination of death or non-fatal myocardial infarction (MI) at follow-up (mean of 1.4 years).
  
  
  RESULTS
  At follow-up, 47 patients had experienced an adverse event. Using the continuous score of the PHQ-2 and the recommended cutoff > or =3, depressive symptoms were not associated with adverse events (ps > 0.05). Using a cutoff > or =2, depressive symptoms were significantly associated with adverse events (HR: 1.89; 95% CI: 1.06-3.35) and remained significant in adjusted analysis (HR: 1.90; 95% CI: 1.05-3.44). Depressive symptoms were associated with an increased risk of adverse events in men (HR: 2.69; 95% CI: 1.36-5.32) but not in women (HR: 0.76; 95% CI: 0.24-2.43); these results remained in adjusted analysis.
  
  
  CONCLUSIONS
  Depression screening with a two-item scale and a cutoff score of > or =2 was independently associated with adverse events at follow-up. The PHQ-2 is a brief and valid measure that can easily be used post PCI to identify patients at risk for adverse health outcomes.
authors: CoRPS - Center of Research on Psychology in Somatic diseases, Tilburg University, Tilburg, The Netherlands. s.s.pedersen@uvt.nl
authors: Susanne S
authors: SS
authors: Pedersen
authors: Johan
authors: J
authors: Denollet
authors: Peter
authors: P
authors: de Jonge
authors: Cihan
authors: C
authors: Simsek
authors: Patrick W
authors: PW
authors: Serruys
authors: Ron T
authors: RT
authors: van Domburg
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D003863:Depression / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D054855:Drug-Eluting Stents / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects; D011379:Prognosis; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales / Q000592:standards*; D012307:Risk Factors
chemical_list: D017239:Paclitaxel