title: The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life.
abstract: BACKGROUND
  It is common to find substantial Alzheimer disease (AD) lesions, i.e., neuritic beta-amyloid plaques and neurofibrillary tangles, in the autopsied brains of elderly subjects with normal cognition assessed shortly before death. We have termed this status asymptomatic AD (ASYMAD). We assessed the morphologic substrate of ASYMAD compared to mild cognitive impairment (MCI) in subjects from the Nun Study. In addition, possible correlations between linguistic abilities in early life and the presence of AD pathology with and without clinical manifestations in late life were considered.
  
  
  METHODS
  Design-based stereology was used to measure the volumes of neuronal cell bodies, nuclei, and nucleoli in the CA1 region of hippocampus (CA1). Four groups of subjects were compared: ASYMAD (n = 10), MCI (n = 5), AD (n = 10), and age-matched controls (n = 13). Linguistic ability assessed in early life was compared among all groups.
  
  
  RESULTS
  A significant hypertrophy of the cell bodies (+44.9%), nuclei (+59.7%), and nucleoli (+80.2%) in the CA1 neurons was found in ASYMAD compared with MCI. Similar differences were observed with controls. Furthermore, significant higher idea density scores in early life were observed in controls and ASYMAD group compared to MCI and AD groups.
  
  
  CONCLUSIONS
  1) Neuronal hypertrophy may constitute an early cellular response to Alzheimer disease (AD) pathology or reflect compensatory mechanisms that prevent cognitive impairment despite substantial AD lesions; 2) higher idea density scores in early life are associated with intact cognition in late life despite the presence of AD lesions.
authors: Division of Neuropathology, Department of Pathology, Johns Hopkins University, School of Medicine, Ross Building 558, 720 Rutland Avenue, Baltimore, MD 21205, USA.
authors: D
authors: D
authors: Iacono
authors: W R
authors: WR
authors: Markesbery
authors: M
authors: M
authors: Gross
authors: O
authors: O
authors: Pletnikova
authors: G
authors: G
authors: Rudow
authors: P
authors: P
authors: Zandi
authors: J C
authors: JC
authors: Troncoso
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology; D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology / Q000517:prevention & control; D002452:Cell Count; D002466:Cell Nucleolus / Q000473:pathology; D048429:Cell Size; D002470:Cell Survival / Q000502:physiology; D003072:Cognition Disorders / Q000473:pathology* / Q000503:physiopathology; D015331:Cohort Studies; D019610:Cytoprotection / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D006984:Hypertrophy / Q000209:etiology; D007805:Language Development Disorders / Q000453:epidemiology; D008137:Longitudinal Studies; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D020127:Recovery of Function / Q000502:physiology; D012307:Risk Factors; D014705:Verbal Behavior / Q000502:physiology*