Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation.
Beta-amyloid (Abeta) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Abeta-induced toxicity. Abeta (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from Abeta by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against Abeta-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.
Kim
Hyo-Shin
HS
Department of Immunology, College of Pharmacy, Research Institute for Translational System Biomics, Chung-Ang University, Seoul, Korea.
Sul
Donggeun
D
Lim
Ji-Youn
JY
Lee
Dongho
D
Joo
Seong Soo
SS
Hwang
Kwang Woo
KW
Park
So-Young
SY
D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016716:PC12 Cells; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D016875:tau Proteins / Q000378:metabolism*
D016229:Amyloid beta-Peptides; D000872:Anthocyanins; D018696:Neuroprotective Agents; D016875:tau Proteins; C017185:delphinidin; D002118:Calcium