Antiviral properties of glycyrrhizic acid and its semisynthetic derivatives.
Some natural triterpenes exert a definite antiviral activity on several human viruses. New synthetic derivatives of glycyrrhizic acid (GL) are even more active than the parental molecule. GL can alter the expression of viral genes involved in cell transformation, thus opening a new window for speculating on viral cancerogenesis.
Pompei
Raffaello
R
Sezione di Microbiologia, Dept. of STB, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy. rpompei@unica.it
Laconi
Samuela
S
Ingianni
Angela
A
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015967:Gene Expression Regulation, Viral / Q000187:drug effects; D019695:Glycyrrhizic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D014780:Viruses / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development
D000998:Antiviral Agents; D019695:Glycyrrhizic Acid