Decorin suppresses bone metastasis in a breast cancer cell line.
Decorin, the prototype of an expanding family of small leucine-rich proteoglycans, is involved in a number of cellular processes including matrix assembly, fibrillogenesis and the control of cell proliferation. In this study, we investigated the role of decorin in suppressing tumor aggressiveness and bone metastases. We used a metastatic breast cancer cell line, MDA-MB-231, to show that decorin causes marked growth suppression bothin vitro and in vivo. A cytomegaloviral vector containing the decorin transgene caused greatly reduced cell growth, motility and observed metastases. Bone metastases were decreased by >90% upon decorin transfection. These results demonstrate a novel role for decorin in the reduction or prevention of tumor metastases in this breast cancer model and could eventually lead to improved therapies for metastatic breast cancer.
Araki
Kentaro
K
Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan.
Wakabayashi
Hiroki
H
Shintani
Ken
K
Morikawa
Joji
J
Matsumine
Akihiko
A
Kusuzaki
Katsuyuki
K
Sudo
Akihiro
A
Uchida
Atsumasa
A
D000818:Animals; D001859:Bone Neoplasms / Q000517:prevention & control* / Q000556:secondary* / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology*; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D058575:Decorin; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000502:physiology*; D005260:Female; D015316:Genetic Therapy; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D010014:Osteolysis / Q000473:pathology; D011509:Proteoglycans / Q000235:genetics / Q000502:physiology*
C546878:DCN protein, human; C546879:Dcn protein, mouse; D058575:Decorin; D016326:Extracellular Matrix Proteins; D011509:Proteoglycans