title: Glycolipid ester-type heterodimers from Ipomoea tyrianthina and their pharmacological activity.
abstract: Tyrianthins A (1) and B (2), two new partially acylated glycolipid ester-type heterodimers were isolated from Ipomoea tyrianthina. Scammonic acid A was determined as the glycosidic acid in both monomeric units. Tyrianthin A (1) (IC(50) 0.24+/-0.09 microM and E(max) 81.80+/-0.98%), and tyrianthin B (2) (IC(50) 0.14+/-0.08 microM and E(max) 87.68+/-0.72%) showed significant in vitro relaxant effect on aortic rat rings, in endothelium- and concentration-dependent manners. Also, these compounds were able to increase the release of GABA and glutamic acid in brain cortex, and displayed weak antimycobacterial activity.
authors: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico.
authors: Ismael
authors: I
authors: León-Rivera
authors: Gumersindo
authors: G
authors: Mirón-López
authors: Samuel
authors: S
authors: Estrada-Soto
authors: Francisco
authors: F
authors: Aguirre-Crespo
authors: María del Carmen
authors: Mdel C
authors: Gutiérrez
authors: Gloria María
authors: GM
authors: Molina-Salinas
authors: Gerardo
authors: G
authors: Hurtado
authors: Gabriel
authors: G
authors: Navarrete-Vázquez
authors: Elizur
authors: E
authors: Montiel
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019281:Dimerization; D018698:Glutamic Acid / Q000378:metabolism; D006017:Glycolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D027741:Ipomoea / Q000737:chemistry*; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D014665:Vasodilator Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000995:Antitubercular Agents; D006017:Glycolipids; D014665:Vasodilator Agents; C543951:tyrianthin A; C543950:tyrianthin B; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid