Mitochondrial calcium and the permeability transition in cell death.
Dysregulation of Ca(2+) has long been implicated to be important in cell injury. A Ca(2+)-linked process important in necrosis and apoptosis (or necrapoptosis) is the mitochondrial permeability transition (MPT). In the MPT, large conductance permeability transition (PT) pores open that make the mitochondrial inner membrane abruptly permeable to solutes up to 1500 Da. The importance of Ca(2+) in MPT induction varies with circumstance. Ca(2+) overload is sufficient to induce the MPT. By contrast after ischemia-reperfusion to cardiac myocytes, Ca(2+) overload is the consequence of bioenergetic failure after the MPT rather than its cause. In other models, such as cytotoxicity from Reye-related agents and storage-reperfusion injury to liver grafts, Ca(2+) appears to be permissive to MPT onset. Lastly in oxidative stress, increased mitochondrial Ca(2+) and ROS generation act synergistically to produce the MPT and cell death. Thus, the exact role of Ca(2+) for inducing the MPT and cell death depends on the particular biologic setting.
Lemasters
John J
JJ
Center for Cell Death, Injury and Regeneration, Medical University of South Carolina, Charleston, SC 29425, USA. JJLemasters@musc.edu
Theruvath
Tom P
TP
Zhong
Zhi
Z
Nieminen
Anna-Liisa
AL
D000818:Animals; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000502:physiology*; D000083162:Mitochondrial Permeability Transition Pore; D015428:Myocardial Reperfusion Injury / Q000209:etiology; D018384:Oxidative Stress; D012202:Reye Syndrome / Q000209:etiology
D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D002118:Calcium