Fertility-preserving treatment in young women with well-differentiated endometrial carcinoma and severe atypical hyperplasia of endometrium.
A retrospective study on 25 women (8 with endometrial carcinoma, 17 with severe endometrial atypical hyperplasia) under 35 years treated with progestin showed that six cases (75%) in the endometrial carcinoma (EC) group and 17 (100%) in the atypical hyperplasia (AH) group responded to the treatment, and among the 14 complete responders, 4 (40%) patients with AH had 7 pregnancies and 3 healthy deliveries. Given accurate pretreatment assessment, progestin therapy is a feasible management option to preserve fertility for young women with well-differentiated endometrial carcinoma or severe atypical hyperplasia of endometrium.
Yu
Mei
M
Department of Obstetrics/Gynecology, Peking Union Medical College Hospital, Beijing, People's Repulic of China.
Yang
Jia-xin
JX
Wu
Ming
M
Lang
Jing-he
JH
Huo
Zhen
Z
Shen
Keng
K
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D002454:Cell Differentiation; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000187:drug effects / Q000473:pathology; D005260:Female; D005298:Fertility; D005500:Follow-Up Studies; D006801:Humans; D006908:Hydroxyprogesterones / Q000008:administration & dosage; D006965:Hyperplasia; D007247:Infertility, Female / Q000517:prevention & control*; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage*; D019290:Megestrol Acetate / Q000008:administration & dosage; D011372:Progestins / Q000008:administration & dosage; D012074:Remission Induction; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D012720:Severity of Illness Index
D018931:Antineoplastic Agents, Hormonal; D006908:Hydroxyprogesterones; D011372:Progestins; D000077713:17 alpha-Hydroxyprogesterone Caproate; D017258:Medroxyprogesterone Acetate; D019290:Megestrol Acetate