title: Expression of the apoptosis gene reaper in homeotic, segmentation and other mutants in Drosophila.
abstract: Apoptosis is an essential process required for development and morphogenesis in metazoan organisms. The apoptosis pathway and cell death machinery have been extensively studied, but little is known how apoptosis genes are regulated in the course of development . In this study, we analyzed the transcriptional regulation of the pro-apoptotic gene reaper (rpr) by performing whole-mount in situ hybridization in embryos mutant for a number of transcription factor genes in Drosophila melanogaster. In sum, our data show that all factors studied have very specific temporal and spatial effects on rpr transcription . Thus, our results reinforce the concept that apoptosis is an essential process for morphogenesis and that apoptosis related genes very tight developmental factors identified in sculpting the morphology of various embryonic structures by modulating the apoptosis pathway.
authors: MPI for Development Biology, Department of Molecular Bilogy, AC I. Lohmann, 72076 Tübingen, Germany.
authors: Zongzhao
authors: Z
authors: Zhai
authors: M A Sokrates
authors: MA
authors: Stein
authors: Ingrid
authors: I
authors: Lohmann
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D019521:Body Patterning / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000196:embryology / Q000378:metabolism; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics; D017403:In Situ Hybridization / Q000379:methods; D009154:Mutation
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; C086973:rpr protein, Drosophila