title: A case-control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: the role of antibodies against human papillomavirus and other risk factors.
abstract: A case-control study was conducted in 140 people with histology proven cutaneous squamous cell carcinoma (SCC) and 454 controls, nested within 2 cohorts of organ transplant recipients (OTR) recruited in London and Oxford between 2002 and 2006. All participants had a skin examination, completed a questionnaire and had serum tested for antibodies against the L1 antigen of 34 HPV types using Luminex technology. SCC was more common in men than women (odds ratio [OR] = 1.7, 95% confidence interval [CI]: 1.1-2.8, p = 0.02) and in people with susceptibility to burn easily (OR = 3.0, 95%CI: 1.9-4.8; p < 0.001). The risk increased with increasing age (p-trend < 0.001), increasing time since transplant (p-trend < 0.001), increasing self-reported number of sunburns as a child (p-trend < 0.001) and with the presence of viral warts (p < 0.001). As expected, antibodies against HPV 16 were associated with a self-reported history of an abnormal cervical smear among women (OR 5.1, 95%CI: 2.6-10.2) and antibodies against HPV 6 were associated with a self-reported history of genital warts (OR 4.0, 95%CI: 2.2-7.2). However, no clear associations between any of the HPV types examined (including cutaneous betaHPVs) and SCC were identified. For example, the seroprevalence of HPV 5 was 15% among cases and 9% among controls (p = 0.09) and the seroprevalence of HPV 8 was 23% among cases and 21% among controls (p = 0.6). Nor was seropositivity to multiple types associated with SCC. These serological data do not provide evidence for a role for HPV in the aetiology of cutaneous SCC among OTR in two UK-based populations.
authors: Cancer Epidemiology Unit, University of Oxford, Headington, Oxford, United Kingdom. dcasabonne@iconcologia.net
authors: Delphine
authors: D
authors: Casabonne
authors: Aoife
authors: A
authors: Lally
authors: Liza
authors: L
authors: Mitchell
authors: Kristina M
authors: KM
authors: Michael
authors: Tim
authors: T
authors: Waterboer
authors: Michael
authors: M
authors: Pawlita
authors: Beata
authors: B
authors: Imko-Walczuk
authors: Fenella
authors: F
authors: Wojnarowska
authors: Charlotte
authors: C
authors: Proby
authors: Catherine
authors: C
authors: Harwood
authors: Robert
authors: R
authors: Newton
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000209:etiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D039841:Leukocyte L1 Antigen Complex / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016377:Organ Transplantation / Q000009:adverse effects*; D027383:Papillomaviridae / Q000276:immunology*; D030361:Papillomavirus Infections / Q000150:complications* / Q000276:immunology; D011379:Prognosis; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000209:etiology
chemical_list: D007074:Immunoglobulin G; D039841:Leukocyte L1 Antigen Complex