Stroke mimicking encephalopathy as an initial manifestation of diffuse large B-cell lymphoma.
BACKGROUND
Systemic lymphoma can be difficult to recognize due to its diverse manifestations. Paraneoplastic leukoencephalopathy has rarely been reported in the context of lymphoma.


METHODS
We report a 45-year-old man with systemic lymphoma whose initial manifestation was sudden-onset leukoencephalopathy, mimicking stroke. This patient, who was eventually diagnosed with diffuse large B-cell lymphoma, initially presented with sudden cognitive impairment and gait disturbance. Radiological studies suggested a paraneoplastic leukoencephalopathy. Chemotherapy for lymphoma resulted in clinical and radiological improvement.


CONCLUSIONS
The presented case indicates that diffuse large B-cell lymphoma may initially appear as a treatable leukoencephalopathy.
Kim
Jeong-Min
JM
Department of Neurology, Stroke & Neural Stem Cell Laboratory in the Clinical Research Institute, Stem Cell Research Center, Seoul National Hospital, Seoul, Korea.
Jung
Keun-Hwa
KH
Lee
Soon-Tae
ST
Park
Hee-Kwon
HK
Chu
Kon
K
Roh
Jae-Kyu
JK