title: Pathological changes induced by rancid feed in rats and effects on growth and protein utilisation.
abstract: The objective of this trial was to study the effect of rancid feeds on the health status and growth of rats and to determine the pathological changes induced by dietary rancidity. Forty-two weaned male rats (body weight: 69.3 +/- 1.0 g) were divided into seven experimental groups (n = 6 each). Rats in the different groups were fed diets containing meat-and-bone meal at an inclusion rate of 19 to 22%, low or high in peroxides and high in organic acids, with or without antioxidant. The diets were isoproteic (10%) and isolipidic (6%). During the 26-day-long trial (5 days for adjustment and 21 days for the main period) the body weight gain and the feed consumption were recorded. At the end of the trial detailed gross and histopathological examinations were performed. Feeding high-peroxide feed mixtures for 21 days significantly (P < 0.05) decreased feed intake and liveweight gain, while high organic acid concentration had only slight negative effects. Antioxidant supplementation alleviated the harmful effects, especially in the high-peroxide group. The ingestion of rancid feed mixtures and the subsequent decreased feed intake caused a decrease of glycogen content in the hepatocytes, accompanied by a slight centrolobular fatty infiltration. Peroxides caused lymphocyte depletion in the spleen, decreased the size of Malpighian bodies and the number of lymphoblasts, and altered the spermatogenesis. The protective effect of the antioxidant mixture seemed to be negligible in this respect.
authors: Szent István University, Institute of Animal Breeding, Nutrition and Laboratory Animal Science, Faculty of Veterinary Science, P.O. Box 2 H-1400 Budapest, Hungary. Fekete.Sandor@aotk.szie.hu
authors: Sándor György
authors: SG
authors: Fekete
authors: Emese
authors: E
authors: Andrásofszky
authors: Róbert
authors: R
authors: Glávits
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D004032:Diet / Q000662:veterinary; D004044:Dietary Proteins / Q000378:metabolism*; D004435:Eating; D022781:Hepatocytes / Q000187:drug effects; D015227:Lipid Peroxidation; D008099:Liver / Q000166:cytology; D008297:Male; D051381:Rats; D013154:Spleen / Q000473:pathology; D013737:Testis / Q000473:pathology
chemical_list: D000975:Antioxidants; D004044:Dietary Proteins