title: An outbreak of varicella in elementary school children with two-dose varicella vaccine recipients--Arkansas, 2006.
abstract: BACKGROUND
  In June 2006, the Advisory Committee on Immunization Practices (ACIP) expanded its June 2005 recommendation for a second dose of varicella vaccine during outbreaks to a recommendation for routine school entry second dose varicella vaccination. In October 2006, the Arkansas Department of Health was notified of a varicella outbreak among students where some received a second dose during an outbreak-related vaccination campaign in February 2006.
  
  
  METHODS
  The outbreak was investigated using a school-wide parental survey with a follow-up survey of identified case patients. Vaccination status was verified using state and local immunization records. Limited laboratory testing confirmed circulation of wild-type varicella, including varicella in 2-dose vaccine recipients.
  
  
  RESULTS
  Vaccination information was available for 871 (99%) of the 880 children. Varicella vaccination coverage was 97% (2-dose, 39%; 1-dose, 58%). A review of the February vaccination clinic found no deficiencies; lot numbers did not differ between cases and noncases. Varicella was confirmed by PCR in 5 (42%) of 12 lesion specimens and by IgM in 1 (6%) of 16 serum specimens. Varicella was reported in 84 children, including 25 (30%) two-dose and 53 (63%) one-dose recipients. Attack rates among 2-dose recipients (10.4%) and 1-dose recipients (14.6%) were not significantly different (RR: 0.72, 95% CI: 0.44-1.15). All 2-dose recipients and 80% of 1-dose recipients reported having 50 or fewer skin lesions.
  
  
  CONCLUSIONS
  This outbreak is the first to document varicella in both 1- and 2-dose vaccine recipients; both groups had mild disease. The vaccine effectiveness of 1 and 2 doses were similar.
authors: Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA, USA. Philip.gould@pentagon.af.mil
authors: Philip L
authors: PL
authors: Gould
authors: Jessica
authors: J
authors: Leung
authors: Connie
authors: C
authors: Scott
authors: D Scott
authors: DS
authors: Schmid
authors: Helen
authors: H
authors: Deng
authors: Adriana
authors: A
authors: Lopez
authors: Sandra S
authors: SS
authors: Chaves
authors: Meredith
authors: M
authors: Reynolds
authors: Linda
authors: L
authors: Gladden
authors: Rafael
authors: R
authors: Harpaz
authors: Sandra
authors: S
authors: Snow
mesh_terms: D001131:Arkansas; D016009:Chi-Square Distribution; D002644:Chickenpox / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D019433:Chickenpox Vaccine / Q000008:administration & dosage* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D006801:Humans; D032541:Mass Vaccination; D016133:Polymerase Chain Reaction; D012574:Schools; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires
chemical_list: D019433:Chickenpox Vaccine