title: Successful treatment of Kasabach-Merritt syndrome with vincristine and diagnosis of the hemangioma using three-dimensional imaging.
abstract: Kasabach-Merritt syndrome is a life-threatening congenital disorder characterized by an enlarging hemangioma, thrombocytopenia, and consumption coagulopathy. We report the case of a one-month male infant who presented with a large cutaneous tumor in his right axilla with ecchymosis, thrombocytopenia, and chronic consumption coagulopathy. Three-dimensional computed tomography was useful for accurate diagnosis of the cutaneous tumor and for determining the precise vascular constitution of the hemangioma, suggesting the efficacy of this method for diagnosing Kasabach-Merritt syndrome. Although administration of a corticosteroid was not effective, additional administration of vincristine resulted in the reversal of thrombocytopenia and coagulopathy with reduction of the hemangioma.
authors: Department of Pediatrics, Hiroshima University, Hiroshima, Japan.
authors: Keiichi
authors: K
authors: Hara
authors: Tomoaki
authors: T
authors: Yoshida
authors: Teruyuki
authors: T
authors: Kajiume
authors: Norioki
authors: N
authors: Ohno
authors: Hiroshi
authors: H
authors: Kawaguchi
authors: Masao
authors: M
authors: Kobayashi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D001550:Benzamidines; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use; D006391:Hemangioma / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D013577:Syndrome; D013921:Thrombocytopenia / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D001550:Benzamidines; D006146:Guanidines; D014750:Vincristine; C032855:nafamostat