title: FDG PET/CT imaging in primary osseous and soft tissue sarcomas: a retrospective review of 212 cases.
abstract: OBJECTIVE
  The aims of this study are to evaluate the sensitivity of FDG PET/CT for detection of soft tissue and osseous sarcomas on the basis of FDG avidity.
  
  
  METHODS
  We retrospectively evaluated 212 consecutive patients with known soft tissue or osseous sarcoma who had undergone a FDG PET/CT study for the initial staging or assessment of recurrence of disease. The maximum standardized uptake value (SUVmax) of each primary and/or most intense metastatic lesion was measured and compared with the histological data provided in the final pathological reports. An SUVmax of 2.5 or greater was considered positive for our analysis.
  
  
  RESULTS
  Sufficient histopathological data were available for 160 soft tissue sarcomas and 52 osseous sarcomas. FDG PET/CT detected 93.9% of all sarcomas with a sensitivity of 93.7% for soft tissue sarcomas and 94.6% for osseous sarcomas. The sensitivities of the most common sarcoma histologies were 100% for leiomyosarcomas, 94.7% for osteosarcomas, 100% for Ewing's sarcomas, 88.9% for liposarcomas, 80.0% for synovial sarcomas, 100% for gastrointestinal stromal tumors, 87.5% for malignant peripheral nerve sheath tumors, 100% for fibroblastic and myoblastic sarcomas, and 100% for malignant fibrohistiocytic tumors. The receiver-operating characteristic curve revealed an area under the curve of 94% for the discrimination of low-grade and high-grade sarcomas imaged for initial staging by FDG PET/CT.
  
  
  CONCLUSIONS
  The combined metabolic and morphological information of FDG PET/CT imaging allows high sensitivity for the detection of various sarcomas and accurate discrimination between newly diagnosed low-grade and high-grade sarcomas.
authors: Service of Nuclear Medicine, Lakeshore General Hospital, 160 Stillview Street, Pointe-Claire, Canada. charestm@hotmail.com
authors: Mathieu
authors: M
authors: Charest
authors: Marc
authors: M
authors: Hickeson
authors: Robert
authors: R
authors: Lisbona
authors: Javier-A
authors: JA
authors: Novales-Diaz
authors: Vilma
authors: V
authors: Derbekyan
authors: Robert E
authors: RE
authors: Turcotte
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012509:Sarcoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18