Antibacterial properties of mesoporous copper-doped silica xerogels.
Mesoporous copper-doped silica xerogels (m-SXCu) with antibacterial properties were synthesized by a sol-gel process, and the morphology, structure and composition of m-SXCu were characterized. The results show that m-SXCu5 with a high surface area of 463.1 m(2) g(-1) have a mesoporous structure with a pore size of about 2 nm. The addition of Cu from 1 to 5 wt% to m-SXCu had a slight effect on the surface area and a not-so-obvious effect on the mesoporous size of m-SXCu. Cu ions can be released from m-SXCu into the simulated body fluid, and the release rate depends significantly on their number. The m-SXCu possessed good antibacterial activity against both E. coli and S. aureus, in which the antibacterial rate reached 99% for m-SXCu5 at 1 h while reaching 99% for all m-SXCu at 24 h. The antibacterial rate was improved with the increase of the amount of Cu, indicating that addition of Cu ions to m-SX enhanced its antibacterial activity.
Wu
Xiaohui
X
Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People's Republic of China.
Ye
Liang
L
Liu
Kun
K
Wang
Wei
W
Wei
Jie
J
Chen
Fangping
F
Liu
Changsheng
C
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D005782:Gels / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D010714:Phosphatidylethanolamines; D012822:Silicon Dioxide / Q000737:chemistry*
C410262:1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine; D000900:Anti-Bacterial Agents; D005782:Gels; D007477:Ions; D010714:Phosphatidylethanolamines; D012822:Silicon Dioxide; D003300:Copper