Calcineurin contributes to spatial memory impairment induced by rapid eye movement sleep deprivation.
Recent evidence suggests that rapid eye movement (REM) sleep deprivation (REMSD) causes learning and memory deficits. However, the mechanism of REMSD-induced memory impairment remains unclear. Calcineurin (CaN) is involved in synaptic plasticity and is known as a negative constraint on learning and memory. Here we report that 72 h REMSD by the modified multiple platform method in rats resulted in spatial memory impairment in the Morris water maze and elevated hippocampal cytosolic CaN activity, both of which were reversed after 18 h sleep recovery. CaN expression in the whole-tissue homogenate of the hippocampus was not altered by REMSD. The results suggest that elevated hippocampal CaN activity is involved in REMSD-induced spatial memory impairment.
Wang
Gui-Ping
GP
Department of Neurology, Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, Shanghai, PR China.
Huang
Liu-Qing
LQ
Wu
Hui-Juan
HJ
Zhang
Lin
L
You
Zhen-Dong
ZD
Zhao
Zhong-Xin
ZX
D000704:Analysis of Variance; D000818:Animals; D015153:Blotting, Western; D019703:Calcineurin / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000502:physiology; D012892:Sleep Deprivation / Q000150:complications / Q000378:metabolism*; D013028:Space Perception / Q000502:physiology; D013997:Time Factors
D019703:Calcineurin