Opiate antagonists suppress ACTH(1-24)-induced excessive grooming in the rat.
Intraventricular injection of ACTH(1-24) in rats induces excessive grooming behavior, and subsequent peripheral administration of specific opiate antagonists suppresses this peptide-induced grooming response. Intraventricular injection of morphine mimics both in intact and hypophysectomized rats' - to a certain extent - peptide-induced grooming. The results suggest similarities in the interaction of morphine and ACTH(1-24) with central nervous structures.
Gispen
W H
WH
Division of Molecular Neurobiology, Rudolf Magnus Institute for Pharmacology, Institute of Molecular Biology, Padualaan 8, Utrecht, The Netherlands.
Wiegant
V M
VM