Preeclampsia--a placenta developmental biology perspective.
There are abundant theories in the scientific literature that propose a range of pathophysiological pathways for preeclampsia. In this review we discuss some of the contributions made to this field from the perspective of a placental developmental biology laboratory. We discuss an underlying immune component of preeclampsia associated with expression of HLA-G and also a beneficial function of decidual NK cells. We conclude by summarizing newer findings regarding the anti-angiogenic expression of soluble fms-like tyrosine kinase (sFlt-1) and its role in the development of preeclampsia.
Goldman-Wohl
Debra
D
Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Centers, Mt. Scopus, Jerusalem, Israel. dwohl@hadassah.org.il
Yagel
Simcha
S
D005260:Female; D006680:HLA Antigens / Q000378:metabolism; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D009389:Neovascularization, Pathologic / Q000276:immunology; D018919:Neovascularization, Physiologic / Q000276:immunology; D010920:Placenta / Q000098:blood supply / Q000276:immunology*; D021041:Placental Circulation / Q000276:immunology; D010929:Placentation / Q000276:immunology; D011225:Pre-Eclampsia / Q000097:blood / Q000276:immunology*; D011247:Pregnancy; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood / Q000276:immunology
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1