title: A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
abstract: We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.
authors: DeCode Genetics, Reykjavik, Iceland. daniel.gudbjartsson@decode.is
authors: Daniel F
authors: DF
authors: Gudbjartsson
authors: Hilma
authors: H
authors: Holm
authors: Solveig
authors: S
authors: Gretarsdottir
authors: Gudmar
authors: G
authors: Thorleifsson
authors: G Bragi
authors: GB
authors: Walters
authors: Gudmundur
authors: G
authors: Thorgeirsson
authors: Jeffrey
authors: J
authors: Gulcher
authors: Ellisiv B
authors: EB
authors: Mathiesen
authors: Inger
authors: I
authors: Njølstad
authors: Audhild
authors: A
authors: Nyrnes
authors: Tom
authors: T
authors: Wilsgaard
authors: Erin M
authors: EM
authors: Hald
authors: Kristian
authors: K
authors: Hveem
authors: Camilla
authors: C
authors: Stoltenberg
authors: Gayle
authors: G
authors: Kucera
authors: Tanya
authors: T
authors: Stubblefield
authors: Shannon
authors: S
authors: Carter
authors: Dan
authors: D
authors: Roden
authors: Maggie C Y
authors: MC
authors: Ng
authors: Larry
authors: L
authors: Baum
authors: Wing Yee
authors: WY
authors: So
authors: Ka Sing
authors: KS
authors: Wong
authors: Juliana C N
authors: JC
authors: Chan
authors: Christian
authors: C
authors: Gieger
authors: H-Erich
authors: HE
authors: Wichmann
authors: Andreas
authors: A
authors: Gschwendtner
authors: Martin
authors: M
authors: Dichgans
authors: Gregor
authors: G
authors: Kuhlenbäumer
authors: Klaus
authors: K
authors: Berger
authors: E Bernd
authors: EB
authors: Ringelstein
authors: Steve
authors: S
authors: Bevan
authors: Hugh S
authors: HS
authors: Markus
authors: Konstantinos
authors: K
authors: Kostulas
authors: Jan
authors: J
authors: Hillert
authors: Sigurlaug
authors: S
authors: Sveinbjörnsdóttir
authors: Einar M
authors: EM
authors: Valdimarsson
authors: Maja-Lisa
authors: ML
authors: Løchen
authors: Ronald C W
authors: RC
authors: Ma
authors: Dawood
authors: D
authors: Darbar
authors: Augustine
authors: A
authors: Kong
authors: David O
authors: DO
authors: Arnar
authors: Unnur
authors: U
authors: Thorsteinsdottir
authors: Kari
authors: K
authors: Stefansson
mesh_terms: D001281:Atrial Fibrillation / Q000150:complications / Q000235:genetics*; D001483:Base Sequence; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D020521:Stroke / Q000150:complications / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins; C071660:ZFHX3 protein, human