title: A comparison between CLNA and CLA effects on body fat, serum parameters and liver composition.
abstract: The potential of conjugated linoleic acid (CLA) as an anti-obesity molecule for humans is still a matter for debate. Thus, a great deal of scientific work is focussed on the research of new effective molecules without deleterious effects on health. The aim of the present work was to analyse the effects of jacaranda seed oil, rich in a conjugated linolenic acid (CLNA), jacaric acid (cis-8,trans-10,cis-12), on body fat, serum parameters and liver composition in rats, and to compare these effects with those of trans-10,cis-12 CLA. Twenty-six male Wistar rats were divided into three groups fed with high-fat diets, supplemented or not (control group) with 0.5% trans-10,cis-12 CLA (CLA group) or 0.5% jacaric acid (CLNA group) for 7 weeks. No statistical differences in food intake or in final body weight were found. Whereas CLA reduced adipose tissue size, CLNA did not. Both CLA and CLNA significantly reduced non-HDL-cholesterol. In spite of a lack of significant changes in glucose and insulin levels, HOMA-IR index was significantly increased, as well as did non-esterified fatty acid levels in CLNA-fed rats. No changes in liver composition were observed. In conclusion, under our experimental conditions, jacaric acid, unlike CLA, does not show a body-fat lowering effect. Even though it leads to a healthy lipoprotein profile, it impairs insulin function. Consequently, it cannot be proposed as an anti-obesity molecule.
authors: Department of Nutrition and Food Sciences. Faculty of Pharmacy, University of the Basque Country, Paseo de la Universidad, 7, 01006 Vitoria, Spain.
authors: J
authors: J
authors: Miranda
authors: A
authors: A
authors: Fernández-Quintela
authors: M T
authors: MT
authors: Macarulla
authors: I
authors: I
authors: Churruca
authors: C
authors: C
authors: García
authors: V M
authors: VM
authors: Rodríguez
authors: E
authors: E
authors: Simón
authors: M P
authors: MP
authors: Portillo
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010938:Plant Oils / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry
chemical_list: D044243:Linoleic Acids, Conjugated; D010938:Plant Oils