Cell-induced intracellular controlled release of membrane impermeable cysteine from a mesoporous silica nanoparticle-based drug delivery system.
A mesoporous silica nanoparticle-based intracellular cysteine delivery system that could be induced and regulated by cell-produced natural antioxidants was synthesized.
Mortera
Renato
R
Dipartimento di Scienza dei Materiali e Ingegneria Chimica Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino, Italy.
Vivero-Escoto
Juan
J
Slowing
Igor I
II
Garrone
Edoardo
E
Onida
Barbara
B
Lin
Victor S-Y
VS
D000975:Antioxidants / Q000378:metabolism; D002463:Cell Membrane Permeability; D049109:Cell Proliferation / Q000187:drug effects; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D053768:Metal Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
D000975:Antioxidants; D004337:Drug Carriers; D012822:Silicon Dioxide; D003545:Cysteine