Melatonin-induced changes in the sensory activation of acute epileptic foci.
Intraperitoneal, intravenous and intracisternal injection of various amounts (50-1000 microg/kg) of melatonin in cats did not significantly change the focal epileptiform activity produced in various cortical areas and limbic structures by topical application of various convulsant agents. However, when the focus was located in primary sensory areas the sensory evoked activation of the epileptiform activity was reduced or suppressed. The present report and other literature data support the hypothesis that melatonin may change the response of epileptic neurons to sensory stimuli.
Fariello
R G
RG
Clarke Institute of Psychiatry, University of Toronto, Department of Psychopharmacology, Toronto M5T 1R8, Canada.
Bubenik
G A
GA