title: Fenofibrate causes regression of endometriotic implants: a rat model.
abstract: Fenofibrate -a peroxisome proliferator-activated receptor-a agonist- is an angiostatic agent that is commonly used in human liver diseases, therefore it may interfere with the angiogenetic process required for endometriosis. In a rat endometriosis model, we demonstrated that peritoneal implant areas and vascular endothelial growth factor levels in the peritoneal flud were significantly decreased in high dose or low dose finofibrate and luprolide acetate treated groups compared to control.
authors: Obstetrics and Gynecology, Baskent University School of Medicine, Ankara, Turkey.
authors: Gogsen
authors: G
authors: Onalan
authors: Hulusi B
authors: HB
authors: Zeyneloglu
authors: Nilufer
authors: N
authors: Bayraktar
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000187:drug effects / Q000473:pathology / Q000637:transplantation; D005260:Female; D011345:Fenofibrate / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000960:Hypolipidemic Agents; D011345:Fenofibrate