title: A case report: a dog with acute onset of Hepatozoon canis infection.
abstract: We present a clinical overview of a dog with acute onset of Hepatozoon canis infection. A stray female beagle dog of unknown age was referred to Kagoshima University showing anemia. Blood tests revealed the presence of anemia, thrombocytopenia, hyperproteinemia, polyclonal gammopathy, hypoalbuminemia, and elevated creatine kinase and alkaline phosphatase activities. In addition, capsule-like organisms were detected in the cytoplasm of approximately 50% of neutrophils in blood smears. H. canis infection was confirmed by polymerase chain reaction and DNA sequencing analyses. Amplified DNA fragments revealed 100% identity to the 18S ribosomal RNA gene of H. canis. The clinical symptoms improved after the administration of antibiotics. Hepatozoonosis in dogs is rare, but veterinarians should be alert to its possible acute onset.
authors: Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan.
authors: Masato
authors: M
authors: Sakuma
authors: Yoshitaka
authors: Y
authors: Nakahara
authors: Hiroyuki
authors: H
authors: Suzuki
authors: Masato
authors: M
authors: Uchimura
authors: Zin
authors: Z
authors: Sekiya
authors: Asuka
authors: A
authors: Setoguchi
authors: Yasuyuki
authors: Y
authors: Endo
mesh_terms: D000740:Anemia / Q000097:blood / Q000469:parasitology / Q000662:veterinary*; D000818:Animals; D003044:Coccidia / Q000235:genetics / Q000302:isolation & purification*; D003048:Coccidiosis / Q000097:blood / Q000469:parasitology / Q000662:veterinary*; D016054:DNA, Protozoan / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000097:blood / Q000469:parasitology*; D004285:Dogs; D005260:Female; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012337:RNA, Ribosomal, 18S / Q000737:chemistry / Q000235:genetics
chemical_list: D016054:DNA, Protozoan; D012337:RNA, Ribosomal, 18S