Fenofibrate causes regression of endometriotic implants: a rat model.
Fenofibrate -a peroxisome proliferator-activated receptor-a agonist- is an angiostatic agent that is commonly used in human liver diseases, therefore it may interfere with the angiogenetic process required for endometriosis. In a rat endometriosis model, we demonstrated that peritoneal implant areas and vascular endothelial growth factor levels in the peritoneal flud were significantly decreased in high dose or low dose finofibrate and luprolide acetate treated groups compared to control.
Onalan
Gogsen
G
Obstetrics and Gynecology, Baskent University School of Medicine, Ankara, Turkey.
Zeyneloglu
Hulusi B
HB
Bayraktar
Nilufer
N
D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000187:drug effects / Q000473:pathology / Q000637:transplantation; D005260:Female; D011345:Fenofibrate / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D000960:Hypolipidemic Agents; D011345:Fenofibrate