title: High sensitive determination of zinc with novel water-soluble small molecular fluorescent sensor.
abstract: A high sensitive method of quantitative analysis for the determination of zinc in the nutrition supplements has been developed by using a novel water-soluble fluorescent sensor HQ3: (8-pyridylmethyloxy-2-methyl-quinoline). Under the optimized condition of 67 mM phosphate buffer, pH 7.4, and 5% (v/v) DMSO, the zinc concentration showed good linear relationship with fluorescence intensity in the range of 7.5 x 10(-8) to 2.5 x 10(-5) M with the detection limit of 1.5 x 10(-8) M. HQ3 exhibited high selectivity to zinc comparing with other metal ions except for cadmium. The developed analytical method was successfully used for determining the content of zinc in a real sample of zinc gluconate solution of Sanchine.
authors: Department of Pharmaceutical Analysis, College of Pharmacy, Wuhan University, Wuhan, Hubei 430072, China.
authors: Ying
authors: Y
authors: Weng
authors: Zilin
authors: Z
authors: Chen
authors: Fang
authors: F
authors: Wang
authors: Lin
authors: L
authors: Xue
authors: Hua
authors: H
authors: Jiang
mesh_terms: D019587:Dietary Supplements / Q000032:analysis*; D004492:Edetic Acid / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D005942:Gluconates / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D016014:Linear Models; D011804:Quinolines / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014867:Water; D015032:Zinc / Q000032:analysis*
chemical_list: D005456:Fluorescent Dyes; D005942:Gluconates; D011804:Quinolines; D014867:Water; D004492:Edetic Acid; C037219:quinoline; D015032:Zinc; C030691:gluconic acid