title: Effects of laparoscopically-assisted vaginal hysterectomy compared with abdominal hysterectomy on immune function.
abstract: This study evaluated the effects of laparoscopically assisted vaginal hysterectomy (LAVH) and abdominal hysterectomy (AH) on the immune system. Between May 2007 and July 2008, 84 women with uterine myoma were randomized in a double-blind manner to undergo LAVH (n = 42) or AH (n = 42). Plasma levels of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), T-lymphocyte CD3(+), CD4(+) and CD8(+) subpopulations, and natural killer (NK) cells were measured 24 h before and 24 h and 72 h after surgery. The IL-6, TNF-alpha and CRP levels in both groups increased significantly after surgery compared with pre-operative levels, and were significantly lower in the LAVH versus the AH group. Post-operative CD3(+) and CD8(+) T-cell counts in the AH group decreased significantly compared with pre-operative levels, whereas in the LAVH group they decreased but not to a statistically significant degree. Post-operative CD4(+) T-cell counts in the AH group also decreased significantly at 24 h after surgery, but were significantly increased at 72 h. In conclusion, LAVH does not significantly affect immune function compared with AH, suggesting the preservation of post-operative immunity, however further clinical studies are necessary.
authors: Department of Obstetrics and Gynaecology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin City, Heilongjiang Province, China.
authors: Q
authors: Q
authors: Yue
authors: R
authors: R
authors: Ma
authors: D-W
authors: DW
authors: Mao
authors: T-J
authors: TJ
authors: Dong
authors: L
authors: L
authors: Sun
authors: X-X
authors: XX
authors: Geng
authors: S-Y
authors: SY
authors: Han
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D003710:Demography; D005260:Female; D006801:Humans; D007045:Hysterectomy, Vaginal / Q000379:methods*; D007107:Immune System / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D010535:Laparoscopy; D007889:Leiomyoma / Q000097:blood / Q000601:surgery; D019990:Perioperative Care; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014594:Uterine Neoplasms / Q000097:blood / Q000601:surgery
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein