title: Acute effect of transcatheter closure on right ventricular function in patients with atrial septal defect assessed by tissue Doppler imaging.
abstract: OBJECTIVE
  Echocardiographic measurement of right ventricular function in patients with atrial septal defect (ASD) is challenging. The Doppler myocardial performance index (MPI) may provide a method of assessing function in these patients. The aim of this study was to evaluate right ventricular function and its changes after transcatheter closure in patients with ASD using MPI by tissue Doppler imaging (TDI).
  
  
  METHODS
  MPI, defined as the sum of isovolumic relaxation and isovolumic contraction time divided by ejection time, was measured by tissue Doppler imaging and pulsed Doppler (PD), respectively. Measurement of time intervals and MPI with TDI and PD were performed in 46 patients with ASD before closure, and at 3 days, 1 month after closure. Twenty-two healthy volunteers served as control subjects.
  
  
  RESULTS
  Both MPI obtained by TDI and PD increased significantly in patients with ASD compared with control subjects (TDI: 0.41 +/- 0.07 vs. 0.32 +/- 0.04, P < 0.001; PD: 0.41 +/- 0.07 vs. 0.31 +/- 0.04, P < 0.001). There were highly significant correlations between MPI values obtained by TDI and by PD in patients with ASD and in control subjects, respectively (r = 0.46, P = 0.001; r = 0.72, P < 0.001, respectively). After transcatheter closure, the MPI obtained by TDI decreased markedly in patients with ASD (3 days after closure: 0.37 +/- 0.06, P = 0.004; 1 month after closure: 0.33 +/- 0.05, P < 0.001, respectively).
  
  
  CONCLUSIONS
  The TDI-derived MPI can be used to assess the global right ventricular function in patients with ASD. Compared with control subjects, the MPI was significantly higher in patients with ASD suggesting decreased right ventricular function. After transcatheter closure, the MPI decreased markedly and right ventricular function improved in patients with ASD.
authors: Department of Cardiology, Zhongda Hospital & School of Clinical Medicine, Southeast University, Nanjing, China. dingjiandong@163.com
authors: Jiandong
authors: J
authors: Ding
authors: Genshan
authors: G
authors: Ma
authors: Chen
authors: C
authors: Wang
authors: Yaoyao
authors: Y
authors: Huang
authors: Xiaoli
authors: X
authors: Zhang
authors: Jian
authors: J
authors: Zhu
authors: Fengxiang
authors: F
authors: Lu
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D006328:Cardiac Catheterization; D016022:Case-Control Studies; D002648:Child; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006305:Health Status Indicators; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D013223:Statistics as Topic; D013318:Stroke Volume; D016278:Ventricular Function, Right / Q000502:physiology; D055815:Young Adult