Helping the helpers!
T follicular helper (Tfh) cells are crucial for generating humoral immune responses. In this issue of Immunity, Schmitt et al. (2009) reveal the differentiation of human Tfh cells is dependent on dendritic cell-derived interleukin-12.
Ma
Cindy S
CS
Immunology Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Tangye
Stuart G
SG
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018664:Interleukin-12 / Q000276:immunology* / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D018664:Interleukin-12