Effect of taurine, GABA and glutamate on the distribution of Na(+) and K(+) ions between the isolated synaptosomes and incubation medium.
Isolated synaptosomes of calf brain cortex lost 90% of their original Na(+) content and 70% of their K(+) content during 30 min incubation in Na(+)- and K(+)-free iso-osmotic medium. Electrical stimulation, and 5 mmol/l of taurine or GABA significantly reduced the outflow of Na(+) and K(+) ions during incubation, but 5 mmol/l of glutamate strongly increased their outflow. The effect of glutamate on ion outflow was slightly reduced by external electrical pulses.
Lähdesmäki
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P
Department of Biochemistry, University of Oulu, Oulu, Finland.
Pajunen
A
A