title: Partially matched related donor transplantation can achieve outcomes comparable with unrelated donor transplantation for patients with hematologic malignancies.
abstract: OBJECTIVE
  The study aimed to compare the outcomes of patients undergoing hematopoietic stem cell transplantation (HSCT) from partially matched related donors (PMRD) and unrelated donors (URD) for hematologic malignancies without the use of in vitro T cell depletion.
  
  
  METHODS
  HSCT was done on 297 consecutive patients from URDs (n = 78) and PMRDs (n = 219) during the same time period. Incidences of graft-versus-host disease (GVHD), relapse, nonrelapse mortality, overall survival, and leukemia-free survival between the PMRD and URD groups were compared.
  
  
  RESULTS
  All patients achieved full engraftment. The cumct65ulative incidences of grades II to IV acute GVHD in the PMRD and URD cohorts were 47% [95% confidence interval (95% CI), 33-62%] versus 31% (CI, 20-42%; P = 0.033), with a relative risk of 1.72 (95% CI, 1.01-2.94; P = 0.046). The incidence of chronic GVHD did not differ significantly between the two cohorts (P = 0.17). The 2-year incidences of nonrelapse mortality and relapse were 20% (CI, 15-26%) versus 18% (CI, 10-27%), with P = 0.98, and 12% (CI, 8-16%) versus 18% (CI, 10-27%), with P = 0.12, for the PMRD versus the URD cohort, respectively. The 4-year overall survival and leukemia-free survival were 74% (CI, 67-80%) versus 74% (CI, 62-85%), with P = 0.98, and 67% (CI, 59-75%) versus 61% (CI, 47-74%), with P = 0.74, respectively.
  
  
  CONCLUSIONS
  Our comparisons show that every major end point, including relapse, nonrelapse mortality, overall survival, and leukemia-free survival, was comparable between the PMRD and the URD groups.
authors: Peking University People's Hospital, Institute of Hematology, Beijing 100044, China. xjhrm@medmail.com.cn
authors: Huang
authors: H
authors: Xiao-Jun
authors: Xu
authors: X
authors: Lan-Ping
authors: Liu
authors: L
authors: Kai-Yan
authors: Liu
authors: L
authors: Dai-Hong
authors: Wang
authors: W
authors: Yu
authors: Chen
authors: C
authors: Huan
authors: Chen
authors: C
authors: Yu-Hong
authors: Han
authors: H
authors: Wei
authors: Wang
authors: W
authors: Jing-Zhi
authors: Chen
authors: C
authors: Yao
authors: Zhang
authors: Z
authors: Xiao-Hui
authors: Shi
authors: S
authors: Hong-Xia
authors: Wang
authors: W
authors: Feng-Rong
authors: Tang
authors: T
authors: Fei-Fei
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000401:mortality; D019337:Hematologic Neoplasms / Q000601:surgery*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006650:Histocompatibility Testing; D006801:Humans; D007938:Leukemia / Q000601:surgery; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D016019:Survival Analysis; D015996:Survival Rate; D014019:Tissue Donors; D055815:Young Adult