title: ADAN: a database for prediction of protein-protein interaction of modular domains mediated by linear motifs.
abstract: BACKGROUND
  Most of the structures and functions of proteome globular domains are yet unknown. We can use high-resolution structures from different modular domains in combination with automatic protein design algorithms to predict genome-wide potential interactions of a protein. ADAN database and related web tools are online resources for the predictive analysis of ligand-domain complexes. ADAN database is a collection of different modular protein domains (SH2, SH3, PDZ, WW, etc.). It contains 3505 entries with extensive structural and functional information available, manually integrated, curated and annotated with cross-references to other databases, biochemical and thermodynamical data, simplified coordinate files, sequence files and alignments. Prediadan, a subset of ADAN database, offers position-specific scoring matrices for protein-protein interactions, calculated by FoldX, and predictions of optimum ligands and putative binding partners. Users can also scan a query sequence against selected matrices, or improve a ligand-domain interaction.
  
  
  BACKGROUND
  ADAN is accessible at http://adan-embl.ibmc.umh.es/ or http://adan.crg.es/.
authors: Instituto de Biologia Molecular y Celular, Edificio Torregaitan, Universidad Miguel Hernandez, Elche, Alicante, Spain.
authors: J A
authors: JA
authors: Encinar
authors: G
authors: G
authors: Fernandez-Ballester
authors: I E
authors: IE
authors: Sánchez
authors: E
authors: E
authors: Hurtado-Gomez
authors: F
authors: F
authors: Stricher
authors: P
authors: P
authors: Beltrao
authors: L
authors: L
authors: Serrano
mesh_terms: D000465:Algorithms; D020816:Amino Acid Motifs; D001665:Binding Sites; D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D025941:Protein Interaction Mapping; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D020539:Sequence Analysis, Protein; D012984:Software
chemical_list: D011506:Proteins