title: Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
abstract: Interleukin 22 (IL-22) is a cytokine produced by the T(H)-17 lineage of helper T cells and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation. Here we characterize a population of human skin-homing memory CD4(+) T cells that expressed the chemokine receptors CCR10, CCR6 and CCR4 and produced IL-22 but neither IL-17 nor interferon-gamma (IFN-gamma). Clones isolated from this population produced IL-22 only and had low or undetectable expression of the T(H)-17 and T helper type 1 (T(H)1) transcription factors RORgammat and T-bet. The differentiation of T cells producing only IL-22 was efficiently induced in naive T cells by plasmacytoid dendritic cells in an IL-6- and tumor necrosis factor-dependent way. Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology.
authors: Institute for Research in Biomedicine, Bellinzona, Switzerland.
authors: Thomas
authors: T
authors: Duhen
authors: Rebekka
authors: R
authors: Geiger
authors: David
authors: D
authors: Jarrossay
authors: Antonio
authors: A
authors: Lanzavecchia
authors: Federica
authors: F
authors: Sallusto
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation; D006801:Humans; D007156:Immunologic Memory; D066298:In Vitro Techniques; D020381:Interleukin-17 / Q000096:biosynthesis*; D007378:Interleukins / Q000096:biosynthesis*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D054447:Receptors, CCR10 / Q000378:metabolism; D054398:Receptors, CCR4 / Q000378:metabolism; D054399:Receptors, CCR6 / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D011988:Receptors, Thyroid Hormone / Q000378:metabolism; D012867:Skin / Q000276:immunology*; D020825:T-Box Domain Proteins / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D000097043:Interleukin-22; D000098815:T-bet Transcription Factor
chemical_list: D020381:Interleukin-17; D007378:Interleukins; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D054447:Receptors, CCR10; D054398:Receptors, CCR4; D054399:Receptors, CCR6; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; D020825:T-Box Domain Proteins; D000097043:Interleukin-22; D000098815:T-bet Transcription Factor; C515706:CCR10 protein, human; C515354:CCR4 protein, human; C106311:CCR6 protein, human; C539900:RORC protein, human