Cognitive inhibition of number/length interference in a Piaget-like task: evidence by combining ERP and MEG.
OBJECTIVE
We combined event-related potential (ERP) and magnetoencephalography (MEG) acquisition and analysis to investigate the electrophysiological markers of the inhibitory processes involved in the number/length interference in a Piaget-like numerical task.


METHODS
Eleven healthy subjects performed four gradually interfering conditions with the heuristic "length equals number" to be inhibited. Low resolution tomography reconstruction was performed on the combined grand averaged electromagnetic data at the early (N1, P1) and late (P2, N2, P3(early) and P3(late)) latencies. Every condition was analyzed at both scalp and regional brain levels.


RESULTS
The inhibitory processes were visible on the late components of the electromagnetic brain activity. A right P2-related frontal orbital activation reflected the change of strategy in the inhibitory processes. N2-related SMA/cingulate activation revealed the first occurrence of the stimuli processing to be inhibited. Both P3 components revealed the working memory processes operating in a medial temporal complex and the mental imagery processes subtended by the precuneus.


CONCLUSIONS
Simultaneous ERP and MEG signal acquisition and analysis allowed to describe the spatiotemporal patterns of neural networks involved in the inhibition of the "length equals number" interference.


CONCLUSIONS
Combining ERP and MEG ensured a sensitivity which could be reached previously only through invasive intracortical recordings.
Joliot
Marc
M
CI-NAPS, Centre d'Imagerie Neurosciences et Applications aux Pathologies, UMR6232, CNRS, CEA, Université de Caen Basse Normandie et Université Paris Descartes, GIP Cyceron, BP 5229, Caen, France. joliot@cyceron.fr
Leroux
Gaëlle
G
Dubal
Stéphanie
S
Tzourio-Mazoyer
Nathalie
N
Houdé
Olivier
O
Mazoyer
Bernard
B
Petit
Laurent
L
D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007600:Judgment; D015225:Magnetoencephalography; D008297:Male; D008433:Mathematics; D009434:Neural Pathways / Q000502:physiology; D025341:Principal Component Analysis; D011930:Reaction Time / Q000502:physiology; D013647:Task Performance and Analysis; D055815:Young Adult