Neural correlates of reward processing in adolescents with a history of inhibited temperament.
Functional imaging data were acquired during performance of a reward-contingency task in a unique cohort of adolescents (ages 14-18 years) who were characterized since infancy on measures of temperamental behavioral inhibition. Neural activation was examined in striatal structures (nucleus accumbens, putamen, caudate) with a known role in facilitating response to salient reward-related cues. Adolescents with a history of behavioral inhibition, relative to noninhibited adolescents, showed increased activation in the nucleus accumbens when they believed their selection of an action would affect reward outcome. Neural responses did not differ between the two groups when participants made a prespecified response that they knew would result in reward or when they produced random motor responses that they knew would not be rewarded. These results link inhibited temperament and perturbed neural responses to reward-contingency cues.
Bar-Haim
Yair
Y
Department of Psychology, Tel Aviv University, Tel Aviv, Israel. yair1@post.tau.ac.il
Fox
Nathan A
NA
Benson
Brenda
B
Guyer
Amanda E
AE
Williams
Amber
A
Nelson
Eric E
EE
Perez-Edgar
Koraly
K
Pine
Daniel S
DS
Ernst
Monique
M
D000293:Adolescent; D000679:Amygdala / Q000502:physiology; D001143:Arousal / Q000502:physiology; D001245:Association Learning / Q000502:physiology; D002421:Caudate Nucleus / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003342:Corpus Striatum / Q000502:physiology*; D003463:Cues; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007266:Inhibition, Psychological; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009042:Motivation / Q000502:physiology*; D009714:Nucleus Accumbens / Q000502:physiology; D010100:Oxygen / Q000097:blood*; D010364:Pattern Recognition, Visual / Q000502:physiology; D010553:Personality Development; D011597:Psychomotor Performance / Q000502:physiology; D011699:Putamen / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012201:Reward; D013694:Temperament
D010100:Oxygen