title: The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides.
abstract: Hypoxia-activated pro-oligonucleotides were synthesized through the commercial phosphoramidite method, and could be readily cleaved to form normal oligos with good hypoxia selectivity in vitro under the effect of reductases, as well as in tumor cell extract.
authors: Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, PR China.
authors: Nan
authors: N
authors: Zhang
authors: Chunyan
authors: C
authors: Tan
authors: Puqin
authors: P
authors: Cai
authors: Peizhuo
authors: P
authors: Zhang
authors: Yufen
authors: Y
authors: Zhao
authors: Yuyang
authors: Y
authors: Jiang
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle; D015195:Drug Design; D004926:Escherichia coli / Q000201:enzymology; D019793:Fluorescein / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D000860:Hypoxia; D009601:Nitroreductases / Q000378:metabolism; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013194:Staining and Labeling
chemical_list: D009841:Oligonucleotides; D011355:Prodrugs; D009601:Nitroreductases; D019793:Fluorescein