title: Complementary chemoenzymatic routes to both enantiomers of febrifugine.
abstract: Two complementary strategies for the synthesis of febrifugine are detailed based on previously developed chemoenzymatic approaches to the 3-hydroxypiperidine skeleton. The introduction of the quinazolone-containing side chain in both strategies was based on an N-acyliminium ion-mediated coupling reaction.
authors: Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, NL-6525 AJ Nijmegen, The Netherlands.
authors: Marloes A
authors: MA
authors: Wijdeven
authors: Rutger J F
authors: RJ
authors: van den Berg
authors: Roel
authors: R
authors: Wijtmans
authors: Peter N M
authors: PN
authors: Botman
authors: Richard H
authors: RH
authors: Blaauw
authors: Hans E
authors: HE
authors: Schoemaker
authors: Floris L
authors: FL
authors: van Delft
authors: Floris P J T
authors: FP
authors: Rutjes
mesh_terms: D002384:Catalysis; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D010880:Piperidines; D011799:Quinazolines; C001207:febrifugine