title: Antimicrobial activity of fullerenes and their hydroxylated derivatives.
abstract: The antimicrobial activities of fullerene C60 and its derivatives against 6 kinds of bacteria and 2 kinds of fungi were evaluated. The tested samples were water-soluble fullerenes (polyvinylpyrrolidone (PVP)/C60, gamma-cyclodextrin (gamma-CD)/C60, and nano-C60) and 3 types of fullerenols (C60(OH)12, C60(OH)36.8H2O, and C60(OH)44.8H2O). Their activities were compared with those of (+)-catechin and hinokitiol from the viewpoint of future application to cosmetics. Although pristine C60 demonstrated no antimicrobial activity, fullerenols exhibited good antimicrobial activity against Propionibacterium acnes, Staphylococcus epidermidis, Candida albicans, and Malassezia furfur. In particular, C60(OH)44 exhibited a strong and wide-ranging antimicrobial activity comparable to that of catechin. This compound exhibits antimicrobial activity via inhibition of microbial cell growth and not via bactericidal activity.
authors: Vitamin C60 BioResearch Corporation, Tatsunuma Tatemono Bldg., 9F, 1-3-19, Yaesu, Chuo-ku, Tokyo 103-0028, Japan.
authors: Hisae
authors: H
authors: Aoshima
authors: Ken
authors: K
authors: Kokubo
authors: Shogo
authors: S
authors: Shirakawa
authors: Masayuki
authors: M
authors: Ito
authors: Shuichi
authors: S
authors: Yamana
authors: Takumi
authors: T
authors: Oshima
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002392:Catechin / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D003358:Cosmetics; D037741:Fullerenes / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D006900:Hydroxylation; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D003358:Cosmetics; D037741:Fullerenes; D002392:Catechin