Interleukin-2 receptor beta gene C627T polymorphism in Korean women with endometriosis: a case-control study.
BACKGROUND
The purpose of this study was to investigate the potential association of the C627T polymorphism in the interleukin-2 receptor beta gene (IL-2R beta) with the risk of endometriosis in Korean women.


METHODS
Two hundred and thirty-seven women with surgically or histologically diagnosed endometriosis of stages III and IV were recruited for this study, and 164 patients with no evidence of endometriosis diagnosed by laparoscopy or laparotomy served as controls. The C627T polymorphism of the IL-2R beta was assessed using the TaqMan allelic discrimination assay. Chi2 analysis was used to examine any differences in genotype distributions and allele frequencies of the IL-2R beta C627T polymorphism between the endometriosis cases and the controls.


RESULTS
There was no statistically significant difference in the frequency of the IL-2R beta C627T polymorphism between the endometriosis patients and the controls (28.7% C/C, 48.1% C/T and 23.2% T/T versus 29.3, 44.5 and 26.2%, respectively, P = 0.72) or in the T allele frequencies (47.3 versus 48.5%, respectively, P = 0.73). Even when the endometriosis cases were subdivided into stages III and IV, no statistically significant differences in genotype distributions or allele frequencies were observed among the three groups.


CONCLUSIONS
Contrary to the recent data reported in a Taiwanese population, our results suggest that the C627T polymorphism of the IL-2R beta gene may not be associated with the risk of endometriosis in the Korean population.
Lee
Gyoung Hoon
GH
Department of Obstetrics and Gynecology, Seoul Medical Center, Seoul, Republic of Korea.
Choi
Young Min
YM
Kim
Sung Hoon
SH
Hong
Min A
MA
Ku
Seung Yup
SY
Kim
Seok Hyun
SH
Kim
Jung Gu
JG
Moon
Shin Yong
SY
D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000453:epidemiology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D053646:Interleukin-2 Receptor beta Subunit / Q000235:genetics*; D007723:Korea; D011110:Polymorphism, Genetic; D012307:Risk Factors
C508020:IL2RB protein, human; D053646:Interleukin-2 Receptor beta Subunit