Carbohydrate metabolism differences between subgroup A1 and B2 strains of Bacillus anthracis as assessed by comparative genomics and functional genetics.
In France, Bacillus anthracis subgroup B2 strains do not metabolize starch or glycogen but can use gluconate, whereas subgroup A1 strains show the inverse pattern. Functional genetic analysis revealed that mutations in the amyS and gntK genes encoding an alpha-amylase and a gluconate kinase, respectively, were responsible for these phenotypes.
Sylvestre
Patricia
P
Institut Pasteur, Unité Toxine et Pathogénie Bactériennes, (URA 2172, CNRS), 75724 Paris cédex 15, France.
Moya
Mary
M
Haustant
Michel
M
Vaissaire
Josée
J
Mock
Michèle
M
D001408:Bacillus anthracis / Q000235:genetics* / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D005602:France; D005798:Genes, Bacterial; D023281:Genomics; D005838:Genotype; D005942:Gluconates / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D009154:Mutation; D010641:Phenotype; D013213:Starch / Q000378:metabolism
D005942:Gluconates; D013213:Starch; D006003:Glycogen; C030691:gluconic acid