[Bone mineral density, PCB, PCQ and PCDF in Yusho].
We measured bone mineral density of the distal end of radius with dual energy X-ray absorptiometry, serum cross-linked N-telopeptides of type I collagen, serum bone-specific alkaline phosphatase, serum Ca, serum P, blood PCB level, blood PCQ level and blood PCDF level in Yusho. As a result, the osteoporosis group (< 70% of the young adult mean [YAM] bone mineral density [BMD]) was observed in 7.1% of the studied male subjects. And, the moderate group (> or = 70% and < 80% of YAM BMD), 16.1%, the normal (> or = 80% of YAM BMD) group was 76.8%. Also, 42.3% of all female tested subjects observed in osteoporosis group. The moderate group, 19.2%, the normal group was 38.5%. There was no difference in PCB blood level, PCQ, PCDF for men and women in osteoporosis group, moderate group, and in the normal group. Serum cross-linked N-telopeptides of type I collagen increased in the male osteoporosis group, but serum bone-specific alkaline phosphatase did not change. This study was inconclusive since the results did not determine the influence that PCB, PCQ, PCDF gave to bone density and bone metabolism.
Yoshimura
Toshiro
T
Department of Health Sciences, Graduate School of Biomedical Sciences, Nagasaki University.
Nakano
Jiro
J
Masuda
Tomoko
T
Tokuda
Masahiro
M
Sakakibara
Atsushi
A
Kataoka
Hideki
H
Okita
Minoru
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001572:Benzofurans / Q000097:blood*; D015519:Bone Density; D002722:Chlorobenzenes / Q000097:blood*; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins / Q000506:poisoning*; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005506:Food Contamination; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000506:poisoning*
D001572:Benzofurans; D002722:Chlorobenzenes; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins; D004785:Environmental Pollutants; C022053:polychlorinated quaterphenyls; D011078:Polychlorinated Biphenyls