Synthesis of fully substituted pyrazoles via regio- and chemoselective metalations.
The full functionalization of the pyrazole ring was achieved by successive regioselective metalations using TMPMgCl x LiCl and TMP(2)Mg x 2 LiCl. Trapping with various electrophiles led to trisubstituted pyrazoles. An application to the synthesis of the acaricide Tebufenpyrad is reported.
Despotopoulou
Christina
C
Department Chemie & Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München, Germany.
Klier
Lydia
L
Knochel
Paul
P
D009942:Organometallic Compounds / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
D009942:Organometallic Compounds; D011720:Pyrazoles; C530465:TMPMgCl.LiCl