[Effect of alendronate on glucocorticoid-induced osteoporosis].
OBJECTIVE
To determine the effect of alendronate on glucocorticoid-induced osteoporosis(GIO).


METHODS
Thirty-five GIO patients were enrolled. Ten milligrams alendronate were prescribed daily for 6 months. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometer (DEXA) after and before the treatment.


RESULTS
BMD at lumbar, neck and trochanter sites of the 35 patients after the treatment was significantly increased compared with those before the treatment (P<0.05). Urine Ca/Cr level was decreased (P<0.05). There was no severe side effect.


CONCLUSIONS
Alendronate is effective and well tolerated for GIO.
Zou
Xiaoling
X
Department of Endocrinology, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, China.
Li
Qinxue
Q
Shi
Chunhua
C
D000328:Adult; D019386:Alendronate / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy*; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use; D012213:Rheumatic Fever / Q000188:drug therapy*
D050071:Bone Density Conservation Agents; D011241:Prednisone; D019386:Alendronate