Two different mechanisms of ampicillin resistance operating in strains of Vibrio cholerae O1 independent of resistance genes.
Autoagglutinable strains of Vibrio cholerae O1 (seven nonfimbriate strains and one fimbriate strain) were transformed to obtain resistance to ampicillin. Two distinct mechanisms were found in these strains. One was operating in nonfimbriate strains by reducing OmpU protein production and the other was operating in a fimbriate strain (Bgd17) by newly overproducing cpxP protein. The twitching motility in the fimbriate Bgd17 strain disappeared depending on the production of cpxP protein, suggesting that fimbriation of V. cholerae O1 is controlled by a two-component signal transduction system.
Nguyen
Dong Tu
DT
Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Ngo
Tuan Cuong
TC
Tran
Huy Hoang
HH
Nguyen
Thi Phuong Lan
TP
Nguyen
Binh Minh
BM
Morita
Kouichi
K
Ehara
Masahiko
M
D018829:Adhesins, Bacterial / Q000096:biosynthesis; D000667:Ampicillin / Q000494:pharmacology*; D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis; D010861:Fimbriae, Bacterial / Q000378:metabolism; D005798:Genes, Bacterial; D008565:Membrane Proteins / Q000096:biosynthesis; D015398:Signal Transduction; D041241:Vibrio cholerae O1 / Q000187:drug effects* / Q000235:genetics*
D018829:Adhesins, Bacterial; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C110674:CpxP protein, bacteria; D008565:Membrane Proteins; C096349:OmpU protein, Vibrio cholerae; D000667:Ampicillin