Proteomic analysis in interstitial lung diseases: a review.
OBJECTIVE
This article aims to review the most recent proteomic findings in tissue and biological fluids and application of new technologies for the study of interstitial lung diseases.


RESULTS
New insights into lung cell biology as well as novel pathogenetic pathways of different interstitial lung diseases, potential targets of treatment and specific biomarkers discovered by proteomics have been reported. Proteomics has been applied to different kinds of biological fluids and the most promising material for proteomic analysis of interstitial lung disease is currently bronchoalveolar lavage fluid.


CONCLUSIONS
The results from proteomic studies on this field could be useful in clinical practice for diagnosis, disease progression and severity of interstitial lung diseases.
Rottoli
Paola
P
Department of Clinical Medicine and Immunological Sciences, University of Siena, Siena, Italy. rottoli@unisi.it
Bargagli
Elena
E
Landi
Claudia
C
Magi
Barbara
B
D001798:Blood Proteins / Q000032:analysis*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D018450:Disease Progression; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D012463:Saliva / Q000737:chemistry; D012720:Severity of Illness Index
D001798:Blood Proteins