title: Cooccurrence of predominant Panton-Valentine leukocidin-positive sequence type (ST) 152 and multidrug-resistant ST 241 Staphylococcus aureus clones in Nigerian hospitals.
abstract: Ninety-six clinical isolates of Staphylococcus aureus from Nigeria were characterized phenotypically and genetically. Twelve multidrug-resistant methicillin (meticillin)-resistant S. aureus (MRSA) isolates carrying a new staphylococcal cassette chromosome mec element and a high proportion of Panton-Valentine leukocidin (PVL)-positive methicillin-susceptible S. aureus (MSSA) isolates were observed. The cooccurrence of multidrug-resistant MRSA and PVL-positive MSSA isolates entails the risk of emergence of a multidrug-resistant PVL-positive MRSA clone.
authors: Department of Medical Microbiology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.
authors: Kenneth O
authors: KO
authors: Okon
authors: Patrick
authors: P
authors: Basset
authors: Auwalu
authors: A
authors: Uba
authors: Johnson
authors: J
authors: Lin
authors: Bukola
authors: B
authors: Oyawoye
authors: Adebayo O
authors: AO
authors: Shittu
authors: Dominique S
authors: DS
authors: Blanc
mesh_terms: D001427:Bacterial Toxins / Q000235:genetics*; D015373:Bacterial Typing Techniques / Q000379:methods; D016000:Cluster Analysis; D016172:DNA Fingerprinting / Q000379:methods; D024901:Drug Resistance, Multiple, Bacterial; D005098:Exotoxins / Q000235:genetics*; D005838:Genotype; D006761:Hospitals; D006801:Humans; D007956:Leukocidins / Q000235:genetics*; D017720:Molecular Epidemiology; D009549:Nigeria; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin