title: Probing a sialyltransferase's recognition domain to prepare alpha(2,8)-linked oligosialosides and analogs.
abstract: We report the first observation that a monosialyl residue is the essential structural element recognized by the enzyme CST-II; this has resulted in an attractive route to synthesize a series of alpha(2,8)-linked oligosialic acids and their thioanalogs in one step.
authors: Alberta Ingenuity Centre for Carbohydrate Science, Department of Chemistry, University of Calgary, 2500, University Drive NW, Calgary, Alberta, Canada T2N 1N4.
authors: Ping
authors: P
authors: Zhang
authors: Amir J
authors: AJ
authors: Zuccolo
authors: Wenling
authors: W
authors: Li
authors: Ruixiang Blake
authors: RB
authors: Zheng
authors: Chang-Chun
authors: CC
authors: Ling
mesh_terms: D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D012794:Sialic Acids / Q000737:chemistry / Q000378:metabolism*; D012799:Sialyltransferases / Q000378:metabolism*
chemical_list: D012794:Sialic Acids; D012799:Sialyltransferases