title: Genetic polymorphisms of hypoxia-inducible factor-1 alpha and cardiovascular disease in hemodialysis patients.
abstract: BACKGROUND
  Hemodialysis patients are prone to ischemic events potentially aggravated by hypoxia. The key player in adaptation to hypoxia is hypoxia-inducible factor-1 alpha (HIF-1alpha). Therefore, we investigated the association of HIF-1alpha polymorphisms with ischemia/hypoxia-related events in hemodialysis patients.
  
  
  METHODS
  Patients on maintenance hemodialysis were enrolled from 4 training hospitals in Korea. Seven single nucleotide polymorphisms (SNP) of HIF-1alpha were genotyped. The association of these SNP with hypoxia-related clinical outcomes (ischemic diseases and anemia) and cancer was analyzed.
  
  
  RESULTS
  A total of 376 patients participated in the study. No significant difference in genotype distribution was found between subjects with and without the hypoxia-related events. Three sets of linkage disequilibrium blocks were made for haplotype analyses (rs2783778 and rs7148720 in 5' upstream region; rs7143164 and rs10873142; rs2301113, rs11549465 and rs2057482). Of these, the CT haplotype in the first set was associated with both acute myocardial infarction and frequent intradialytic hypotension (acute myocardial infarction: adjusted odds ratio = 0.15, 95% CI: 0.03-0.69; frequent intradialytic hypotension: adjusted odds ratio = 0.29, 95% CI: 0.12-0.72).
  
  
  CONCLUSIONS
  Genetic polymorphisms of HIF-1alpha were associated with acute myocardial infarction and intradialytic hypotension in hemodialysis patients.
authors: Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea.
authors: Zhen Lon
authors: ZL
authors: Zheng
authors: Young-Hwan
authors: YH
authors: Hwang
authors: Seong Kyun
authors: SK
authors: Kim
authors: Sejoong
authors: S
authors: Kim
authors: Min Jung
authors: MJ
authors: Son
authors: Han
authors: H
authors: Ro
authors: Su-Ah
authors: SA
authors: Sung
authors: Hyun Hee
authors: HH
authors: Lee
authors: Woo Kyung
authors: WK
authors: Chung
authors: Kwon Wook
authors: KW
authors: Joo
authors: Jaeseok
authors: J
authors: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics*; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000235:genetics* / Q000534:rehabilitation*; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D006435:Renal Dialysis / Q000706:statistics & numerical data*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D055815:Young Adult
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit