title: aGEM: an integrative system for analyzing spatial-temporal gene-expression information.
abstract: BACKGROUND
  The work presented here describes the 'anatomical Gene-Expression Mapping (aGEM)' Platform, a development conceived to integrate phenotypic information with the spatial and temporal distributions of genes expressed in the mouse. The aGEM Platform has been built by extending the Distributed Annotation System (DAS) protocol, which was originally designed to share genome annotations over the WWW. DAS is a client-server system in which a single client integrates information from multiple distributed servers.
  
  
  RESULTS
  The aGEM Platform provides information to answer three main questions. (i) Which genes are expressed in a given mouse anatomical component? (ii) In which mouse anatomical structures are a given gene or set of genes expressed? And (iii) is there any correlation among these findings? Currently, this Platform includes several well-known mouse resources (EMAGE, GXD and GENSAT), hosting gene-expression data mostly obtained from in situ techniques together with a broad set of image-derived annotations.
  
  
  BACKGROUND
  The Platform is optimized for Firefox 3.0 and it is accessed through a friendly and intuitive display: http://agem.cnb.csic.es
authors: GN7 of the National Institute for Bioinformatics and Biocomputing Unit of the National Centre for Biotechnology, Darwin 3, Campus de Cantoblanco, 28049 Madrid, Spain. natalia@cnb.csic.es
authors: Natalia
authors: N
authors: Jiménez-Lozano
authors: Joan
authors: J
authors: Segura
authors: José Ramón
authors: JR
authors: Macías
authors: Juanjo
authors: J
authors: Vega
authors: José María
authors: JM
authors: Carazo
mesh_terms: D019295:Computational Biology / Q000379:methods*; D015870:Gene Expression; D016247:Information Storage and Retrieval / Q000379:methods*; D020407:Internet; D012984:Software