Three new acylated glycosides from the stems of Casearia velutina and their protective effect against H2O2-induced impairment in PC12 cells.
Chemical investigation of the stems of Casearia velutina led to the isolation and structural elucidation of three new acylated glycosides, casearicosides A-C (1-3), together with 13 known compounds. The structures of the new compounds were established by spectroscopic and chemical methods. These isolates were evaluated for protective effects against H(2)O(2)-induced impairment in PC12 cells and inhibitory activity against snake venom phosphodiesterase I. A brief chemotaxonomy of the genus Casearia is also discussed.
Chai
Xing-Yun
XY
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, P R China.
Li
Fei-Fei
FF
Bai
Chang-Cai
CC
Xu
Zheng-Ren
ZR
Shi
Hai-Ming
HM
Tu
Peng-Fei
PF
D000215:Acylation; D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D037821:Casearia / Q000737:chemistry* / Q000145:classification; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006861:Hydrogen Peroxide; D015394:Molecular Structure; D016716:PC12 Cells; D043264:Phosphodiesterase I / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018547:Plant Stems; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats
D000975:Antioxidants; D006027:Glycosides; D010936:Plant Extracts; D020011:Protective Agents; C549437:casearicoside A; C549438:casearicoside B; C549439:casearicoside C; D006861:Hydrogen Peroxide; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom