title: Electrical conductivity and permittivity of murine myocardium.
abstract: A classic problem in traditional conductance measurement of left ventricular (LV) volume is the separation of the contributions of myocardium from blood. Measurement of both the magnitude and the phase of admittance allow estimation of the time-varying myocardial contribution, which provides a substantial improvement by eliminating the need for hypertonic saline injection. We present in vivo epicardial surface probe measurements of electrical properties in murine myocardium using two different techniques (a digital and an analog approach). These methods exploit the capacitive properties of the myocardium, and both methods yield similar results. The relative permittivity varies from approximately 100,000 at 2 kHz to approximately 5000 at 50 kHz. The electrical conductivity is approximately constant at 0.16 S/m over the same frequency range. These values can be used to estimate and eliminate the time-varying myocardial contribution from the combined signal obtained in LV conductance catheter measurements, thus yielding the blood contribution alone. To study the effects of albumin on the blood conductivity, we also present electrical conductivity estimates of murine blood with and without typical administrations of albumin during the experiment. The blood conductivity is significantly altered (p < 0.0001) by administering albumin (0.941 S/m with albumin, 0.478 S/m without albumin).
authors: Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712 USA. karthikraghavan@mail.utexas.edu
authors: Karthik
authors: K
authors: Raghavan
authors: John E
authors: JE
authors: Porterfield
authors: Anil T G
authors: AT
authors: Kottam
authors: Marc D
authors: MD
authors: Feldman
authors: Daniel
authors: D
authors: Escobedo
authors: Jonathan W
authors: JW
authors: Valvano
authors: John A
authors: JA
authors: Pearce
mesh_terms: D000818:Animals; D001790:Blood Physiological Phenomena; D004553:Electric Conductivity; D004562:Electrocardiography / Q000379:methods*; D004566:Electrodes; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010496:Pericardium / Q000502:physiology; D012709:Serum Albumin / Q000494:pharmacology; D016276:Ventricular Function / Q000502:physiology
chemical_list: D012709:Serum Albumin