title: Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients.
abstract: OBJECTIVE
  The appropriate management of low-grade gliomas is still a matter of debate. So far, there are no randomized studies that analyze the impact of surgical resection on patient outcome. The value of the data obtained from the few retrospective reports available is often limited.
  
  
  METHODS
  In the present study, we performed an analysis on data of 130 adult low-grade glioma patients. Extent of the resection was evaluated in correlation to the overall survival (OS) and progression-free survival (PFS) using Cox regression multivariate analysis.
  
  
  RESULTS
  Extended surgery was shown to prolong OS and PFS significantly. Re-surgery in the case of a tumor relapse has a significant impact on OS and PFS, too.
  
  
  CONCLUSIONS
  In summary, we could retrospectively evaluate a large case series of well-defined low-grade gliomas patients with a long follow-up period showing that extended surgery would be the most effective therapy for low-grade glioma patients even in recurrent diseases.
authors: Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany. rezvan_ahmadi@med.uni-heidelberg.de
authors: Rezvan
authors: R
authors: Ahmadi
authors: Ahmadi
authors: A
authors: Rezvan
authors: Christine
authors: C
authors: Dictus
authors: Dictus
authors: D
authors: Christine
authors: Christian
authors: C
authors: Hartmann
authors: Hartmann
authors: H
authors: Christian
authors: Olga
authors: O
authors: Zürn
authors: Zürn
authors: Z
authors: Olga
authors: Lutz
authors: L
authors: Edler
authors: Edler
authors: E
authors: Lutz
authors: Marius
authors: M
authors: Hartmann
authors: Hartmann
authors: H
authors: Marius
authors: Stephanie
authors: S
authors: Combs
authors: Combs
authors: C
authors: Stephanie
authors: Christel
authors: C
authors: Herold-Mende
authors: Herold-Mende
authors: HM
authors: Christel
authors: Christian Rainer
authors: CR
authors: Wirtz
authors: Wirtz Christian
authors: WC
authors: Rainer
authors: Andreas
authors: A
authors: Unterberg
authors: Unterberg
authors: U
authors: Andreas
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy / Q000379:methods / Q000706:statistics & numerical data; D004358:Drug Therapy / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D005910:Glioma / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009361:Neoplasm Invasiveness / Q000503:physiopathology / Q000517:prevention & control; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000517:prevention & control / Q000601:surgery; D038361:Neuronavigation; D019635:Neurosurgical Procedures / Q000379:methods* / Q000706:statistics & numerical data*; D011300:Preoperative Care; D011379:Prognosis; D011878:Radiotherapy / Q000379:methods / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013238:Stereotaxic Techniques; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult