title: Osteoporosis in patients over 50 years of age following restorative proctocolectomy for ulcerative colitis: is DXA screening warranted?
abstract: BACKGROUND
  Ulcerative colitis (UC) and increasing age are associated with an increased risk of osteoporosis. Screening of postmenopausal women and men older than 50 years with ulcerative colitis for osteoporosis is recommended. The prevalence of osteoporosis in restorative proctocolectomy (RPC) patients more than 50 years old is not known.
  
  
  METHODS
  Fifty-three consecutive patients older than age 50 who had undergone RPC for UC underwent a bone density scan (DXA). Sex, smoking status, age at diagnosis of UC, duration of UC, age at RPC, years since RPC, age at DXA, and pouch histological inflammatory score were recorded. The Kruskal-Wallis test and Spearman's correlation coefficient were used to analyze the data.
  
  
  RESULTS
  Fifty-three patients were studied; their median age was 58 years, and the median age at RPC was 45. The prevalence of osteopenia and osteoporosis was 43.4% and 13.2%, respectively. Age at RPC was negatively correlated with bone density (P = 0.041, r = 0.281), and there was a negative correlation approaching significance with age at the time of DXA (P = 0.071, r = -0.250). No other factor studied correlated with bone density.
  
  
  CONCLUSIONS
  The prevalence of osteoporosis and osteopenia found in this study is similar to that reported for UC patients who have not undergone RPC. Patients having RPC should be screened in line with current UC guidelines, targeting those older than 50 years.
authors: Department of Biosurgery and Surgical Technology, Imperial College London, United Kingdom. simon.mclaughlin@nhs.net
authors: Simon D
authors: SD
authors: McLaughlin
authors: Zarah L
authors: ZL
authors: Perry-Woodford
authors: Susan K
authors: SK
authors: Clark
authors: Matthew W
authors: MW
authors: Johnson
authors: Paris P
authors: PP
authors: Tekkis
authors: Paul J
authors: PJ
authors: Ciclitira
authors: R John
authors: RJ
authors: Nicholls
mesh_terms: D000367:Age Factors; D000368:Aged; D015519:Bone Density; D003093:Colitis, Ulcerative / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed