title: Sensitive and efficient detection of thrombus with fibrin-specific manganese nanocolloids.
abstract: In this work, we report novel fibrin targeted "soft-type" manganese-based contrast agents for MRI with the potential to noninvasively image intravascular thrombus which could warrant aggressive medical intervention to preclude subsequent myocardial infarction or stroke.
authors: Division of Cardiology and C-TRAIN, Washington University School of Medicine, St. Louis, MO 63108, USA. dipanjan@wustl.edu
authors: Dipanjan
authors: D
authors: Pan
authors: Angana
authors: A
authors: Senpan
authors: Shelton D
authors: SD
authors: Caruthers
authors: Todd A
authors: TA
authors: Williams
authors: Mike J
authors: MJ
authors: Scott
authors: Patrick J
authors: PJ
authors: Gaffney
authors: Samuel A
authors: SA
authors: Wickline
authors: Gregory M
authors: GM
authors: Lanza
mesh_terms: D003102:Colloids; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry* / Q000378:metabolism*; D017895:Manganese Compounds / Q000737:chemistry / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry / Q000378:metabolism; D010087:Oxides / Q000737:chemistry / Q000378:metabolism; D012680:Sensitivity and Specificity; D013379:Substrate Specificity; D013927:Thrombosis / Q000175:diagnosis*
chemical_list: D003102:Colloids; D003287:Contrast Media; D017895:Manganese Compounds; D010087:Oxides; D019301:Oleic Acid; D008345:Manganese; C027424:manganese oxide; D005337:Fibrin