Inhibition of human aromatase by myosmine.
Myosmine, a minor tobacco alkaloid widely occurring in food products of plant and animal origin, inhibits the conversion of testosterone to estradiol by human aromatase (IC(50): 33+/-2 microM) sevenfold more potent than nicotine (IC(50): 223+/-10 microM) and may have implications for sexual hormone homoeostasis.
Doering
Irene L
IL
Walther Straub Institute, Department of Toxicology, Ludwig-Maximilians University, Munich, Germany.
Richter
Elmar
E
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*; D001141:Aromatase / Q000187:drug effects* / Q000378:metabolism; D047072:Aromatase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D004958:Estradiol / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D008861:Microsomes / Q000378:metabolism; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D013739:Testosterone / Q000378:metabolism
D000470:Alkaloids; D047072:Aromatase Inhibitors; D013739:Testosterone; D004958:Estradiol; D009538:Nicotine; C002398:myosmine; D001141:Aromatase