title: Synergy between chemo- and bio-catalysts in multi-step transformations.
abstract: Cascade synthetic pathways, which allow multi-step conversions to take place in one reaction vessel, are crucial for the development of biomimetic, highly efficient new methods of chemical synthesis. Theoretically, the complexity introduced by combining processes could lead to an improvement of the overall process; however, it is the current general belief that it is more efficient to run processes separately. Inspired by natural cascade procedures we successfully combined a lipase catalyzed amidation with palladium catalyzed coupling reactions, simultaneously carried out on the same molecule. Unexpectedly, the bio- and chemo-catalyzed processes show synergistic behaviour, highlighting the complexity of multi-catalyst systems.
authors: Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands.
authors: Aldo
authors: A
authors: Caiazzo
authors: Paula M L
authors: PM
authors: Garcia
authors: Ron
authors: R
authors: Wever
authors: Jan C M
authors: JC
authors: van Hest
authors: Alan E
authors: AE
authors: Rowan
authors: Joost N H
authors: JN
authors: Reek
mesh_terms: D000577:Amides / Q000737:chemistry; D000586:Amination; D001596:Benzylamines / Q000737:chemistry / Q000378:metabolism; D055162:Biocatalysis; D032701:Biomimetics; D005656:Fungal Proteins; D008049:Lipase / Q000737:chemistry / Q000378:metabolism; D010165:Palladium / Q000737:chemistry
chemical_list: D000577:Amides; D001596:Benzylamines; D005656:Fungal Proteins; D010165:Palladium; C030796:benzylamine; D008049:Lipase; C431349:lipase B, Candida antarctica