title: Carbon dioxide laser-assisted phonosurgery for benign glottic lesions.
abstract: The objectives of the study were (1) to evaluate glottic function following carbon dioxide laser-assisted phonosurgery of benign laryngeal disease, and (2) to assess postoperative glottic morphology and disease recurrence rates, using the study design of comparative prospective non-randomized case series of patients with benign glottic pathology treated by laser-assisted phonosurgery over 10 years. 235 consecutive patients had pre- and postoperative data collected by objective laryngeal examination, videostroboscopy recording of vocal fold mucosal wave movement, electroacoustic voice analysis (statistical analysis: Wilcoxon test) and perceptual voice evaluation. Comparing pre- and postoperative functional results demonstrated a statistically significant improvement in all spectrographically analysed objective voice parameters (P < 0.001). Postoperative morphological analysis confirmed three recurrences of granuloma and one of Reinke's oedema. Carbon dioxide laser-assisted voice restoration for benign glottic disease is effective.
authors: Department of Otorhinolaryngology, Head and Neck Surgery, Queen Alexandra Hospital, Cosham, Portsmouth, Hampshire, PO6 3LY, UK. marcelgeyer@googlemail.com
authors: Marcel
authors: M
authors: Geyer
authors: Gian Peppino
authors: GP
authors: Ledda
authors: Neil
authors: N
authors: Tan
authors: Peter A
authors: PA
authors: Brennan
authors: Roberto
authors: R
authors: Puxeddu
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005931:Glottis; D006801:Humans; D007818:Laryngeal Diseases / Q000503:physiopathology / Q000601:surgery*; D053685:Laser Therapy / Q000295:instrumentation*; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function / Q000502:physiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D014833:Voice Quality / Q000502:physiology*