title: Acquisition-weighted MRSI for detection and quantification of BNCT 10B-carrier L-p-boronophenylalanine-fructose complex, a phantom study.
abstract: Proton magnetic resonance spectroscopy (1H MRS) is a potential method to detect and quantify a boron neutron capture therapy 10B-carrier compound, L-p-boronophenylalanine (BPA), in the brain. However, optimal positioning of MRS voxel to capture tissue with maximal BPA concentration can be challenging. Three dimensional proton magnetic resonance spectroscopic imaging (3D 1H MRSI) provides spectral data covering a large spatial volume, which is a major advantage in detecting and quantifying BPA. BPA detection limit in phantom conditions was determined at 1.5 T using a 3D 1H MRSI protocol with clinically acceptable nominal spatial resolution and duration. Quantification tests for aqueous phantom were performed using both single voxel MRS and 3D MRSI. In 3D MRSI, BPA detection limit was approximately 1.0 mM and BPA quantification accuracy was better than +/-5%. The results suggest that MRSI would be a feasible method for in vivo BPA evaluation in clinical conditions.
authors: Department of Physics, University of Helsinki, Finland.
authors: Marjut
authors: M
authors: Timonen
authors: Leena
authors: L
authors: Kankaanranta
authors: Nina
authors: N
authors: Lundbom
authors: Mika
authors: M
authors: Kortesniemi
authors: Tiina
authors: T
authors: Seppälä
authors: Mauri
authors: M
authors: Kouri
authors: Sauli
authors: S
authors: Savolainen
authors: Sami
authors: S
authors: Heikkinen
mesh_terms: D000465:Algorithms; D000818:Animals; D001896:Boron Compounds / Q000032:analysis*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001923:Brain Chemistry; D004337:Drug Carriers / Q000032:analysis*; D005632:Fructose / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: C089739:4-boronophenylalanine-fructose; D001896:Boron Compounds; D004337:Drug Carriers; D011522:Protons; D005632:Fructose