title: Ebolavirus glycoprotein GP masks both its own epitopes and the presence of cellular surface proteins.
abstract: Ebolavirus (EBOV) is the etiological agent of a severe hemorrhagic fever with a high mortality rate. The spike glycoprotein (GP) is believed to be one of the major determinants of virus pathogenicity. In this study, we demonstrated the molecular mechanism responsible for the downregulation of surface markers caused by EBOV GP expression. We showed that expression of mature GP on the plasma membrane results in the masking of cellular surface proteins, including major histocompatibility complex class I. Overexpression of GP also results in the masking of certain antigenic epitopes on GP itself, causing an illusory effect of disappearance from the plasma membrane.
authors: INSERM, Laboratoire des Filovirus, Lyon, France.
authors: Olivier
authors: O
authors: Reynard
authors: Malgorzata
authors: M
authors: Borowiak
authors: Valentina A
authors: VA
authors: Volchkova
authors: Sebastien
authors: S
authors: Delpeut
authors: Mathieu
authors: M
authors: Mateo
authors: Viktor E
authors: VE
authors: Volchkov
mesh_terms: D002460:Cell Line; D002462:Cell Membrane / Q000821:virology; D015536:Down-Regulation; D029043:Ebolavirus / Q000737:chemistry / Q000472:pathogenicity*; D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D006801:Humans; D008565:Membrane Proteins; D014162:Transfection; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology / Q000502:physiology*
chemical_list: D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D014759:Viral Envelope Proteins; C113189:envelope glycoprotein, Ebola virus