title: Effect of mometasone furoate on nasal congestion model in rats.
abstract: OBJECTIVE
  The present study was performed to evaluate the effect of mometasone furoate on a nasal congestion model in Brown Norway rats.
  
  
  METHODS
  Nasal congestion in rats sensitized with toluene-2,4-diisocyanate (TDI) was measured using whole-body plethysmography which allowed animals to move freely.
  
  
  RESULTS
  Penh (enhanced pause), an index of nasal congestion, was significantly increased after 5% TDI challenge in sensitized rats compared with that in non-sensitized rats. The peak of the increase in Penh appeared at 1 and 5 h after TDI challenge. A single topical administration of mometasone furoate (0.05%) at 1 h before TDI challenge suppressed the increase of Penh in sensitized rats. A significant effect was observed 5-6 h after nasal administration. Almost the same results were obtained with fluticasone propionate (0.05%).
  
  
  CONCLUSIONS
  Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.
authors: Preclinical Research Department, Schering-Plough K.K., Osaka, Japan.
authors: Masami
authors: M
authors: Ogawa
authors: Tae
authors: T
authors: Tsumuro
authors: Miho
authors: M
authors: Takubo
authors: Yuhki
authors: Y
authors: Ueda
authors: Rie
authors: R
authors: Yatsuzuka
authors: Yuko
authors: Y
authors: Kishi
authors: Chiaki
authors: C
authors: Kamei
mesh_terms: D000287:Administration, Topical; D000730:Androstadienes / Q000494:pharmacology; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D000068298:Fluticasone; D008297:Male; D000068656:Mometasone Furoate; D009297:Nasal Mucosa / Q000187:drug effects / Q000503:physiopathology; D015508:Nasal Obstruction / Q000188:drug therapy*; D010993:Plethysmography, Whole Body; D011244:Pregnadienediols / Q000494:pharmacology*; D051381:Rats; D011914:Rats, Inbred BN; D015656:Respiratory Mechanics / Q000187:drug effects; D013997:Time Factors
chemical_list: D000730:Androstadienes; D018926:Anti-Allergic Agents; D011244:Pregnadienediols; D000068656:Mometasone Furoate; D000068298:Fluticasone