Inhibitor of apoptosis (IAP) proteins: novel insights into the cancer-relevant targets for cell death induction.
Inhibitor of apoptosis (IAP) proteins are expressed at high levels in various cancers and block apoptosis at a key node. Therefore, there is currently much interest in IAP antagonists as cancer therapeutics. Structure-based development of selective IAP inhibitors now provides, for the first time, evidence that simultaneous inhibition of the c-IAP proteins and XIAP is necessary for efficient induction of cancer cell death by IAP antagonists.
Fulda
Simone
S
University Children's Hospital, Eythstrasse 24, Ulm, Germany. simone.fulda@uniklinik-ulm.de
D000970:Antineoplastic Agents / Q000627:therapeutic use; D016923:Cell Death / Q000187:drug effects; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology
D000970:Antineoplastic Agents; D051034:Inhibitor of Apoptosis Proteins; D016328:NF-kappa B