NMR analysis, protonation equilibria and decomposition kinetics of tolperisone.
The rate constants of spontaneous and hydroxide-catalyzed decomposition and the tautomer-specific protonation constants of tolperisone, a classical muscle relaxant were determined. A solution NMR method without any separation techniques was elaborated to quantitate the progress of decomposition. All the rate and equilibrium constants were determined at four different temperatures and the activation parameters were calculated. The molecular mechanism of decomposition is proposed.
Orgován
Gábor
G
Department of Pharmaceutical Chemistry, Semmelweis University, Research Group of Drugs of Abuse and Doping Agents, Hungarian Academy of Sciences, Budapest H-1092, Hogyes Endre u. 9, Hungary.
Tihanyi
Károly
K
Noszál
Béla
B
D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D015394:Molecular Structure; D009125:Muscle Relaxants, Central / Q000032:analysis / Q000737:chemistry*; D010070:Oxalates / Q000737:chemistry; D011522:Protons; D013816:Thermodynamics; D013997:Time Factors; D014049:Tolperisone / Q000032:analysis / Q000737:chemistry*
D009125:Muscle Relaxants, Central; D010070:Oxalates; D011522:Protons; D014049:Tolperisone