Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging.
Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe(3)O(4)) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.
Abe
Shigeaki
S
Department of Biomedical Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan. sabe@den.hokudai.ac.jp
Kida
Ikuhiro
I
Esaki
Mitsue
M
Akasaka
Tsukasa
T
Uo
Motohiro
M
Hosono
Toshiaki
T
Sato
Yoshinori
Y
Jeyadevan
Balachandran
B
Kuboki
Yoshinori
Y
Morita
Manabu
M
Tohji
Kazuyuki
K
Watari
Fumio
F
D000818:Animals; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics*; D052203:Ferrosoferric Oxide / Q000737:chemistry* / Q000493:pharmacokinetics*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008856:Microscopy, Fluorescence / Q000379:methods; D009928:Organ Specificity; D014018:Tissue Distribution; D051598:Whole Body Imaging / Q000379:methods*; D014965:X-Rays
D003287:Contrast Media; D052203:Ferrosoferric Oxide