Clinical characteristics of laryngeal cancer in BRCA-1 mutation carriers.
BACKGROUND
The aim of this study was to analyze the occurrence of clinical features characteristic of breast cancer type 1 susceptibility protein (BRCA-1)-dependent tumors in a series of BRCA-1 mutation carriers with laryngeal cancer.


METHODS
The clinical features of five laryngeal cancer patients with BRCA-1 mutations registered in our center were analyzed for: sex, age at diagnosis, age at operation, tumor size and localization, histopathological subtype and grading, lymph node and distant metastases, mode of treatment and long term results of the therapy.


RESULTS
The five patients were all men, with an average age at diagnosis of 52.4 years. The majority of the patients had clinical features typical of BRCA-1-dependent tumors: four out of the five patients had advanced staging at the time of diagnosis and in three of them the disorder disseminated within one year of follow-up.


CONCLUSIONS
Since laryngeal carcinomas in men with BRCA-1 mutations show clinical features characteristic of BRCA-1 dependent tumors, it is reasonable to consider treatment modifications appropriate for this sub-group of tumors.
Jaworowska
Ewa
E
Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, 71-252 Szczecin, Poland. jaworowska@tlen.pl
Tarnowska
Czesława
C
Lubiński
Jakub
J
Serrano-Fernández
Pablo
P
Huzarski
Tomasz
T
Górski
Bogdan
B
Masojć
Bartlomiej
B
Jakubiszyn
Jerzy
J
Korytowska
Aleksandra
A
Kram
Andrzej
A
Rabczynski
Jerzy
J
Lubiński
Jan
J
D019398:Genes, BRCA1; D006580:Genetic Carrier Screening; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation