Hepatosplenic T-cell lymphoma in a patient with Crohn's disease.
BACKGROUND
A 58-year-old man who had a 35-year history of Crohn's disease presented to our IBD center with a disease flare, pararectal fistulas and abscess formation. The patient had previously undergone ileocolic resection for a stenosis and his abscesses had been treated by surgical drainage. He had been taking azathioprine therapy for approximately 5.5 years and had received high-dose steroids. He had also previously taken metronidazole and antihypertensive medications.


METHODS
Physical examination, laboratory investigations including hemoglobin levels and white blood cell counts, genetic testing, CT, bone-marrow biopsy, immunophenotyping by fluorescence-activated cell sorting, polymerase chain reaction analyses, fluorescence in situ hybridization, sputum culture and diagnostic splenectomy.


METHODS
Hepatosplenic T-cell lymphoma.


RESULTS
Splenectomy, antibiotic therapy and chemotherapy with cyclophosphamide.
Beigel
Florian
F
Department of Medicine II, University Hospital, Munich-Grosshadern, Munich, Germany. florian.beigel@med.uni-muenchen.de
Jürgens
Matthias
M
Tillack
Cornelia
C
Subklewe
Marion
M
Mayr
Doris
D
Göke
Burkhard
B
Brand
Stephan
S
Ochsenkühn
Thomas
T
D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide