Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder.
OBJECTIVE
Evidence from family and molecular genetic studies support the hypothesis of involvement of immunologic mechanisms in the pathophysiology of obsessive-compulsive disorder. The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system. Given the importance of NFKBIL1 in the immunological response, the present study investigated the -62A/T polymorphism (rs2071592), located in the promoter region of its gene (NFKBIL1), as a genetic risk factor for the development of obsessive-compulsive disorder.


METHODS
The -62A/T NFKBIL1 polymorphism was investigated in a sample of 111 patients who met DSM-IV criteria for obsessive-compulsive disorder and 272 healthy age- and gender-matched controls.


RESULTS
There were no differences in genotypic distributions between patients and controls (chi2 = 0.98; 2 d.f.; p = 0.61).


CONCLUSIONS
Despite these negative findings, more comprehensive polymorphism coverage within the NFKBIL1 is warranted in larger samples. Populations with different ethnic backgrounds should also be studied.


CONCLUSIONS
The results of the present investigation do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample.
Cordeiro
Quirino
Q
Department and Institute of Psychiatry, Medical School, Universidade de São Paulo, São Paulo, SP, Brazil.
Cappi
Carolina
C
Sampaio
Aline Santos
AS
Palácios
Selma Aliotti
SA
Pereira
Carlos Alberto de Bragança
CA
Shavitt
Roseli Gedanke
RG
Miguel
Eurípedes Constantino
EC
Guilherme
Luiza
L
Hounie
Ana Gabriela
AG
D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D011110:Polymorphism, Genetic
D048868:Adaptor Proteins, Signal Transducing; D000949:Histocompatibility Antigens Class II; C120111:NFKBIL1 protein, human