Is there a neuropathology difference between mild cognitive impairment and dementia?
The number of studies that have investigated the neuropathology of mild cognitive impairment (MCI) is small, but growing. In this paper we have restricted our focus to the consideration of the presence and extent of postmortem findings relevant to the neuropathology of Alzheimer's disease. We have drawn from studies that have investigated the postmortem neurobiology of the brains of persons with cognitive function at the interface between unimpaired normal function and mild but definite dementia. The data derived from these studies suggest that i) the brains of persons with MCI evidence significant neuropathological and neurobiological changes relative to those without cognitive impairment; ii) in general, the neuropathological and neurobiological changes are qualitatively similar to those observed in the brains of persons with frank AD-like dementia; and iii) the neuropathological and neurobiological brain changes associated with MCI are quantitatively less than those of persons who meet criteria for dementia. Thus, the available, albeit limited, data suggests that MCI is associated with the early stages of the neurobiological and neuropathological changes that culminate in the florid lesions of AD; including the accumulation of neuritic plaques, neurofibrillary tangles, synaptic and neurotransmitter associated deficits, and significant neuronal cell death.
Haroutunian
Vahram
V
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY, USA. vahram.haroutunian@mssm.edu
Hoffman
Lisa B
LB
Beeri
Michal Schnaider
MS
D000375:Aging / Q000473:pathology; D000544:Alzheimer Disease / Q000473:pathology* / Q000523:psychology; D001921:Brain / Q000473:pathology*; D016923:Cell Death; D003072:Cognition Disorders / Q000473:pathology* / Q000523:psychology; D003704:Dementia / Q000473:pathology* / Q000523:psychology; D006801:Humans; D016874:Neurofibrillary Tangles / Q000473:pathology; D009474:Neurons / Q000473:pathology; D058225:Plaque, Amyloid / Q000473:pathology; D012720:Severity of Illness Index; D013569:Synapses / Q000473:pathology