title: Dramatic response to platinum in a patient with cancer with a germline BRCA2 mutation.
abstract: We present a case of dramatic response of poor prognosis cancer in a lady with a germline mutation in the BRCA2 gene who was exposed to platinum containing chemotherapy. She is cancer-free 10 years' later. Such cases provide clinical scenarios for the basis of trials of platinum-like agents in individuals with BRCA mutations who develop cancer.
authors: Radiotherapy Department, University College Hospital, London NW1 2BU, UK.
authors: R
authors: R
authors: Moule
authors: A
authors: A
authors: Sohaib
authors: R
authors: R
authors: Eeles
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D024522:Genes, BRCA2; D018095:Germ-Line Mutation; D006801:Humans; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D011379:Prognosis
chemical_list: D009944:Organoplatinum Compounds