title: 6-substituted indolo[1,2-c]quinazolines as new antimicrobial agents.
abstract: A series of 2-o-arylidineaminophenylindoles and their cyclic derivatives (indolo[1,2-c]quinazolines) were synthesized. The reactions occurred under relatively mild conditions and afforded the desired product in good yields. Molecular structures of the synthesized compounds were confirmed by IR, (1)H-NMR,( 13)C-NMR, MS spectra, and elemental analyses. Furthermore, all the final products were screened for in-vitro antibacterial activity against three Gram-positive and three Gram-negative bacteria and also tested for their inhibitory action against three strains of fungi. Compound IIc showed potent activity against all the bacterial (except S. typhimurium) and fungal strains. Especially, compounds IIi and IIj which have isoquinolyl and pyridyl substituents displayed potent antibacterial as well as antifungal activities compared to those of the respective standard drugs Ampicillin and Ketoconazole.
authors: Department of Chemistry, Kakatiya University, Warangal, A. P., India.
authors: Rondla
authors: R
authors: Rohini
authors: Kanne
authors: K
authors: Shanker
authors: P Muralidhar
authors: PM
authors: Reddy
authors: Vasam Chandra
authors: VC
authors: Sekhar
authors: Vadde
authors: V
authors: Ravinder
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects*; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D011799:Quinazolines