A straightforward protocol for one-pot allylic aminations/Stille couplings.
Stannylated allylic carbonates are suitable substrates for Pd-catalyzed allylic aminations. In DMF and with [Pd(allyl)Cl](2) as catalyst, the stannylated allyl amines formed can be directly coupled with electrophiles according to the Stille protocol, giving rise to highly functionalized building blocks in excellent yields.
Bukovec
Christian
C
Universität des Saarlandes, Institut für Organische Chemie, Im Stadtwald, Geb. C4.2, D-66123 Saarbrücken, Germany.
Kazmaier
Uli
U
D000498:Allyl Compounds / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*
D000498:Allyl Compounds; D000588:Amines; D010165:Palladium