title: Abdominal adiposity is associated with elevated C-reactive protein independent of BMI in healthy nonobese people.
abstract: OBJECTIVE
  There is debate over the most appropriate adiposity markers of obesity-associated health risks. We evaluated the relationship between fat distribution and high-sensitivity C-reactive protein (hs-CRP), independent of total adiposity.
  
  
  METHODS
  We studied 350 people with abdominal adiposity (waist-to-hip ratio [WHR] > or =0.9 in male and > or =0.85 in female subjects) and 199 control subjects (WHR <0.9 in male and <0.85 in female subjects) matched for BMI and age. We measured hs-CRP and major cardiovascular risk factors.
  
  
  RESULTS
  Participants with abdominal adiposity had BMI similar to that in control subjects (24.8 +/- 2.5 vs. 24.7 +/- 2.2 kg/m(2), respectively), but significantly higher waist circumference (96.4 +/- 6.0 vs. 83.3 +/- 6.7 cm; P < 0.01) and WHR (1.07 +/- 0.08 vs. 0.85 +/- 0.05; P < 0.001). Compared with the control subjects, participants with abdominal adiposity had an adverse cardiovascular risk factor profile, significantly higher hs-CRP (1.96 +/- 2.60 vs. 1.53 +/- 1.74 mg/dl; P < 0.01), and a twofold prevalence of elevated CRP values (>3 mg/dl).
  
  
  CONCLUSIONS
  In nonobese people, moderate abdominal adiposity is associated with markers of subclinical inflammation independent of BMI.
authors: Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
authors: Emanuela
authors: E
authors: Lapice
authors: Simona
authors: S
authors: Maione
authors: Lidia
authors: L
authors: Patti
authors: Paola
authors: P
authors: Cipriano
authors: Angela A
authors: AA
authors: Rivellese
authors: Gabriele
authors: G
authors: Riccardi
authors: Olga
authors: O
authors: Vaccaro
mesh_terms: D000005:Abdomen; D050154:Adiposity / Q000502:physiology*; D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D002097:C-Reactive Protein