title: Effects of diode laser therapy on the acellular dermal matrix.
abstract: Acellular dermal matrix (ADM) was subcutaneously implanted into calvarian skin of male Wistar rats (n = 40). Low-level laser (lambda 685 nm, 4 J/cm(2)) was locally applied in experimental group (n = 20) above the skin flap. Grafts were harvested at 1, 3, 7 and 14 days after surgery and underwent histological analyses. In treated animals, the extent of edema and the number of inflammatory cells were reduced (P < 0.05). The amount of collagen in graft treated with low-level laser were significantly higher than those of controls (P < 0.05) and were statistically more prominent on the 14th day after surgery. The mean count of fibroblasts was significantly higher in the low-laser therapy group within the 3rd day, showing a marked influx of fibroblasts into area. In conclusion, wound healing of the ADM appear to be positively affected by laser therapy.
authors: Department of Oralmaxillofacial Surgery, PUCRS School of Dentistry, Porto Alegre, Rio Grande do Sul, Brazil. liviaps@ibest.com.br
authors: Lívia Prates
authors: LP
authors: Soares
authors: Marília Gerhardt
authors: MG
authors: de Oliveira
authors: Sílvia Regina
authors: SR
authors: de Almeida Reis
mesh_terms: D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D005347:Fibroblasts / Q000166:cytology; D006085:Graft Survival; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D028022:Low-Level Light Therapy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016038:Skin Transplantation; D017768:Skin, Artificial; D014183:Transplantation, Heterologous; D014945:Wound Healing
chemical_list: C440568:Alloderm; D003094:Collagen