Multiple drug interactions - induced serotonin syndrome: a case report.
Serotonin syndrome is a potentially life-threatening disorder of excessive serotoninergic activity often due to drug interactions. We report a case of serotonin syndrome induced by pharmacokinetic and pharmacodynamic interactions between three different selective serotonin-reuptake inhibitors (SSRI) and possibly ciprofloxacin. Extreme caution is necessary in patients treated with serotonin-reuptake inhibitors who need to be switched to another antidepressant or when they require the addition of concomitant drugs, especially serotoninergic drugs and isoenzimes of cytochrome P450 inhibitors.
Montané
E
E
Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Barriocanal
A
A
Isern
I
I
Parajon
T
T
Costa
J
J
D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000494:pharmacology; D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology; D002939:Ciprofloxacin / Q000009:adverse effects* / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D008297:Male; D020230:Serotonin Syndrome / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000493:pharmacokinetics
D000890:Anti-Infective Agents; D000928:Antidepressive Agents; D002939:Ciprofloxacin; D017367:Selective Serotonin Reuptake Inhibitors