Teeing up transcription on CpG islands.
Eukaryotic cells use elaborate molecular mechanisms to rapidly activate signal-dependent gene expression. New work provides fresh insights into these mechanisms by demonstrating that CpG islands in promoters are nucleosome-destabilizing elements and can facilitate the establishment of an unusual poised transcriptional state (Ramirez-Carrozzi et al., 2009; Hargreaves et al., 2009).
Singh
Harinder
H
Howard Hughes Medical Institute, University of Chicago, Chicago IL 60637, USA. hsingh@uchicago.edu
D000818:Animals; D018899:CpG Islands; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D015533:Transcriptional Activation