Hydrazine-induced liver toxicity is enhanced by glutathione depletion but is not mediated by oxidative stress in HepG2 cells.
Olthof
Evelyn
E
Tostmann
Alma
A
Peters
Wilbert H M
WH
Roelofs
Hennie M J
HM
Wagener
Frank A
FA
Scharstuhl
Alwin
A
Dekhuijzen
P N Richard
PN
Boeree
Martin J
MJ
D000995:Antitubercular Agents / Q000378:metabolism / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D006834:Hydrazines / Q000009:adverse effects / Q000633:toxicity*; D007538:Isoniazid / Q000378:metabolism / Q000633:toxicity; D008099:Liver / Q000166:cytology / Q000473:pathology*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
D000995:Antitubercular Agents; D006834:Hydrazines; D017382:Reactive Oxygen Species; C029424:hydrazine; D005978:Glutathione; D007538:Isoniazid