title: Enteral nutrition improves health-related quality of life in Crohn's disease patients with long disease duration.
abstract: OBJECTIVE
  Although enteral nutrition therapy has been highlighted as maintenance therapy for Crohn's disease, few reports have investigated the impact of enteral nutrition on the health-related quality of life of Crohn's disease patients.
  
  
  METHODS
  We cross-sectionally evaluated the effect of multiple clinical factors including enteral nutrition on the health-related quality of life of Crohn's disease patients focusing on patient disease duration using the Inflammatory Bowel Disease Questionnaire.
  
  
  RESULTS
  Of all 126 patients examined, 95 patients were receiving enteral nutrition. Multiple linear regression analysis using 18 clinical parameters revealed that disease activity was a dominant factor that affected the health-related quality of life of Crohn's disease patients, and that enteral nutrition was also an independent factor that improved the Inflammatory Bowel Disease Questionnaire total score, bowel symptoms, and systemic symptoms for patients with a disease duration of 10 years or more (P = 0.0090, 0.0033, and 0.016, respectively).
  
  
  CONCLUSIONS
  Enteral nutrition improved the health-related quality of life of Crohn's disease patients with long-term disease duration. Thus, enteral nutrition should be recommended as one of the options for maintenance therapy for Crohn's disease.
authors: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
authors: Motoaki
authors: M
authors: Kuriyama
authors: Jun
authors: J
authors: Kato
authors: Naofumi
authors: N
authors: Morimoto
authors: Tsuyoshi
authors: T
authors: Fujimoto
authors: Hiroyuki
authors: H
authors: Kono
authors: Nobuaki
authors: N
authors: Okano
authors: Jiro
authors: J
authors: Miyaike
authors: Takechiyo
authors: T
authors: Morita
authors: Hiroyuki
authors: H
authors: Okada
authors: Seiyuu
authors: S
authors: Suzuki
authors: Toshifumi
authors: T
authors: Yoshioka
authors: Junji
authors: J
authors: Shiode
authors: Yasushi
authors: Y
authors: Shiratori
authors: Yamamoto
authors: Y
authors: Kazuhide
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003424:Crohn Disease / Q000178:diet therapy*; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome