Pathogenesis of Burkholderia pseudomallei and Burkholderia mallei.
Burkholderia pseudomallei and mallei are biological agents of military significance. There has been significant research in recent years to develop medical countermeasures for these organisms. This review summarizes work which details aspects of the pathogenesis of B. pseudomallei and mallei and discusses key scientific questions and directions for future research.
Larsen
Joseph C
JC
Defense Threat Reduction Agency/Joint Science and Technology Office for Chemical and Biological Defense, 8725 John Kingman Road, Fort Belvoir, VA 22060, USA.
Johnson
Nathan H
NH
D000818:Animals; D016667:Bacterial Capsules / Q000235:genetics; D001426:Bacterial Proteins / Q000378:metabolism; D023482:Bioterrorism; D042726:Burkholderia mallei / Q000235:genetics / Q000472:pathogenicity*; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000472:pathogenicity*; D018397:Equidae; D016680:Genome, Bacterial; D005896:Glanders / Q000188:drug therapy / Q000382:microbiology / Q000635:transmission; D006801:Humans; D008554:Melioidosis / Q000188:drug therapy / Q000382:microbiology / Q000635:transmission; D053038:Quorum Sensing; D014774:Virulence
D001426:Bacterial Proteins