Isoplatensimycin: Synthesis and biological evaluation.
Isoplatensimycin, a novel analog of platensimycin, was synthesized via intramolecular dipolar cycloaddition of a carbonyl ylide. Isoplatensimycin showed little activities against strains of Staphylococcus aureus, but exhibited activities against some vancomycin-resistant enteroccoci.
Jang
Ki Po
KP
Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Republic of Korea.
Kim
Chan Hyuk
CH
Na
Seong Wook
SW
Kim
Hiyoung
H
Kang
Heonjoong
H
Lee
Eun
E
D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D062365:Aminobenzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000813:Anilides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016983:Enterococcus / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D020713:Vancomycin Resistance
D062365:Aminobenzoates; D000813:Anilides; D000900:Anti-Bacterial Agents; C543962:isoplatensimycin; D000218:Adamantane; C510909:platensimycin