title: [Expression of survivin, Bcl-2 and p53 during 4-nitro-quinoline 1-oxide-induced rat tongue carcinogenesis].
abstract: OBJECTIVE
  To investigate the expression of survivin during oral carcinogenesis and its relationship with the expression of Bcl-2 and p53.
  
  
  METHODS
  Two-step immunohistochemical method was employed to detect the expression of survivin, Bcl-2 and p53 in 60 rat tongue carcinogenesis specimens induced by 4-nitro-quinoline 1-oxide (4NQO).
  
  
  RESULTS
  Survivin was present in 1/36 cases of normal mucosa, 6/11 cases of oral epithelial dysplasia and 10/11 cases of oral carcinoma. There were significant difference in the expression of survivin among normal mucosa, oral epithelial dysplasia and carcinoma (P < 0.001). While in the 17 cases of positive expression of survivin, Bcl-2 was present in 12 cases and p53 was present in 8 cases. The expression of survivin in oral epithelial dysplasia and carcinoma were significantly higher than that in normal oral mucosa (P < 0.01). The expression of survivin was positively correlated to the expression of Bcl-2 and p53 in rat tongue (P < 0.01).
  
  
  CONCLUSIONS
  The expression of survivin may play an important role in oral carcinogenesis. Survivin, Bcl-2 and p53 may be synergetic in the carcinogenesis of oral cancer.
authors: Department of Oral Medicine, Xiamen Dental Hospital, School of Stomatology, Fujian Medical University, Xiamen Fujian, 361003, China.
authors: Yan-Fen
authors: YF
authors: Zheng
authors: Zuo-Liang
authors: ZL
authors: Chen
authors: Hong-Bo
authors: HB
authors: Chen
authors: Jun
authors: J
authors: Cheng
mesh_terms: D015112:4-Nitroquinoline-1-oxide / Q000009:adverse effects; D000818:Animals; D017209:Apoptosis; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D019254:Genes, bcl-2; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D051381:Rats; D000077022:Survivin; D014062:Tongue Neoplasms / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C516989:Birc5 protein, rat; D008869:Microtubule-Associated Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin; D016159:Tumor Suppressor Protein p53; D015112:4-Nitroquinoline-1-oxide