title: Efficacy of tonsillectomy for patients with recurrence of IgA nephropathy after kidney transplantation.
abstract: From January 2007, we started to perform the tonsillectomy for every patient with recurrent IgA nephropathy (IgAN) after kidney transplantation. Up to September 2008, four recipients with primary IgAN had biopsy-proven recurrent IgAN. They had also progressive hematuria or proteinuria from on the average 14.3 months after transplantation. Then their specimens diagnosed as recurrent IgAN were collected and they underwent tonsillectomies on the average 52.3 months after transplantation. Abnormal urinary findings of all patients favorably improved after tonsillectomy. All cases but one had mild renal injury, where the severity of glomerular lesions, glomerular hypercellularity, segmental lesions, and sclerosis was mild, and no deteriorated serum creatinine (SCr) before their tonsillectomies. Even the case with exacerbated SCr and severe renal injury, where the severity of glomerular lesions was severe, had her urinary findings ameliorated promptly after tonsillectomy likely as others. At present, they have almost no symptoms after tonsillectomy and no remarkable change of SCr level compared with before and after tonsillectomy and maintain ameliorated urinary findings continuously. Tonsillectomy had possibility to be a favorable treatment of hematuria or proteinuria in recurrent IgAN recipients.
authors: Department of Transplantation and Regenerative Surgery, Kyoto Prefectural University Graduate School of Medical Science, Kyoto, Japan. ushi@koto.kpu-m.ac.jp
authors: Hidetaka
authors: H
authors: Ushigome
authors: Tomoyuki
authors: T
authors: Suzuki
authors: Masato
authors: M
authors: Fujiki
authors: Syuji
authors: S
authors: Nobori
authors: Seisuke
authors: S
authors: Sakamoto
authors: Masahiko
authors: M
authors: Okamoto
authors: Koji
authors: K
authors: Urasaki
authors: Norio
authors: N
authors: Yoshimura
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D005922:Glomerulonephritis, IGA / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D012189:Retrospective Studies; D055502:Secondary Prevention; D014068:Tonsillectomy / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome