title: Protection afforded by a herbal medicine, Sho-seiryu-to (TJ-19), against oleic acid-induced acute lung injury in guinea-pigs.
abstract: OBJECTIVE
  The effect of a herbal medicine, Sho-seiryu-to (TJ-19), on oleic acid-induced lung injury, an animal model of acute respiratory distress syndrome or acute lung injury (ARDS/ALI), was examined.
  
  
  METHODS
  Acute lung injury was induced by an intravenous injection of 15 microl/kg oleic acid to guinea-pigs. TJ-19 was administered by a single oral dose (3 g/kg) or by multiple oral doses (0.75 g/kg).
  
  
  RESULTS
  The decrease in partial oxygen pressure of arterial blood (Pao(2)) and the increase in airway vascular permeability induced by the oleic acid injection were attenuated by a single dose of TJ-19. When TJ-19 was administered orally twice a day for two weeks and then oleic acid was injected, a potent prophylactic effect of the drug was observed. TJ-19 also prevented airway vascular hyperpermeability, lung cell injury, oxidative stress and thromboxane A(2) generation, associated with the oleic acid injection.
  
  
  CONCLUSIONS
  TJ-19 significantly attenuated the oleic acid-induced lung injury probably through the antioxidative effect and inhibitory effect of thromboxane A(2) generation, although the precise inhibitory mechanisms were not fully elucidated due to the diversity in constituents of the herbal medicine. We suggest that TJ-19 is a promising drug candidate and a medicinal resource for preventing ARDS/ALI.
authors: Department of Pharmaceutical Sciences, College of Pharmacy, Yanbian University, Yanji, China.
authors: Chang-Qing
authors: CQ
authors: Yang
authors: Yoichi
authors: Y
authors: Ishitsuka
authors: Hiroshi
authors: H
authors: Moriuchi
authors: Saeid
authors: S
authors: Golbidi
authors: Zhen-Ji
authors: ZJ
authors: Jin
authors: Mitsuru
authors: M
authors: Irikura
authors: Tetsumi
authors: T
authors: Irie
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D029001:Herbal Medicine; D008297:Male; D019301:Oleic Acid; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010946:Plants, Medicinal; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis
chemical_list: D004365:Drugs, Chinese Herbal; C090832:sho-seiryu-to; D019301:Oleic Acid; D013928:Thromboxane A2