title: Integr-ating IL-1 alpha in antiviral host defenses.
abstract: Adenoviral vectors used in gene therapy induce inflammation, although the underlying mechanisms are currently unknown. In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity.
authors: Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. kate.fitzgerald@umassmed.edu
authors: Katherine A
authors: KA
authors: Fitzgerald
mesh_terms: D000256:Adenoviridae / Q000276:immunology*; D000818:Animals; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000276:immunology*; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology / Q000821:virology*; D039661:Integrin beta3 / Q000276:immunology*; D053582:Interleukin-1alpha / Q000276:immunology*; D051379:Mice
chemical_list: D039661:Integrin beta3; D053582:Interleukin-1alpha