CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii.
Acinetobacter baumannii has been increasingly associated with hospital-acquired infections, and the presence of multidrug resistance strains is of great concern to clinicians. A. baumannii is thought to possess a great deal of intrinsic resistance to several antimicrobial agents, including chloramphenicol, although the mechanisms involved in such resistance are not well understood. In this work, we have identified a major facilitator superfamily efflux pump present in most A. baumannii strains, displaying strong substrate specificity toward chloramphenicol.
Roca
I
I
Department of Microbiology, Hospital Clínic, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain.
Marti
S
S
Espinal
P
P
Martínez
P
P
Gibert
I
I
Vila
J
J
D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D002702:Chloramphenicol Resistance / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D015378:Imipenem / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D015363:Quinolones / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015363:Quinolones; D013754:Tetracyclines; D015378:Imipenem