Low-grade B-cell proliferation progressing to high-grade B-cell lymphoma.
We present a case of a primary cutaneous lymphoproliferative process, originally diagnosed as cutaneous lymphoid hyperplasia, which progressed to a nodal high-grade diffuse large B-cell lymphoma 3 years after the initial diagnosis. The 2 processes were related by the presence of the same lymphoid clone in the cutaneous and the nodal proliferation.
Martin
Blanca
B
Department of Dermatopathology and daggerSkin Tumour Unit, St John's Institute of Dermatology, London, United Kingdom. blanca.martin@gstt.nhs.uk
Craig
Paul
P
Grattan
Clive
C
Mitchell
Tracey
T
Ferreira
Silvia
S
Whittaker
Sean
S
Robson
Alistair
A
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D050438:Genes, Immunoglobulin Heavy Chain; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy