Esterase activities in the blood, liver and intestine of several preclinical species and humans.
Species and tissue differences in the activity of three major classes of esterases, carboxylesterase (CE), butyrylcholinesterase (BChE) and paraoxonase (PON), were studied. Substantial species differences in activity of these esterases were observed between the mouse, rat, dog monkey and human. Such species differences must be considered when using these preclinical species to optimize the pharmacokinetic properties of ester compounds intended for human use.
Berry
Loren M
LM
Pharmacokinetics and Drug Metabolism, Amgen, Inc., Cambridge, MA, USA. loren.berry@amgen.com
Wollenberg
Lance
L
Zhao
Zhiyang
Z
D000818:Animals; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D002091:Butyrylcholinesterase / Q000378:metabolism*; D043182:Carboxylesterase / Q000378:metabolism*; D004285:Dogs; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D008252:Macaca fascicularis; D051379:Mice; D023421:Models, Animal; D051381:Rats; D013045:Species Specificity
D043182:Carboxylesterase; D002091:Butyrylcholinesterase; D043303:Aryldialkylphosphatase