title: Long-term outcome after suboccipital decompressive craniectomy for malignant cerebellar infarction.
abstract: OBJECTIVE
  Suboccipital decompressive craniectomy (SDC) is a life-saving intervention for patients with malignant cerebellar infarction. However, long-term outcome has not been systematically analyzed.
  
  
  METHODS
  In this monocentric retrospective study we analyzed mortality, long-term functional outcome, and quality of life of all consecutive patients that were treated by SDC for malignant cerebellar infarction in our institution between 1995 and 2006.
  
  
  RESULTS
  A total of 57 patients were identified. All of them were treated by bilateral SDC. An external ventricular drainage was inserted in 82%, necrotic tissue was evacuated in 56% of patients. There were no fatal procedural complications. Five patients were lost for follow-up. In the remaining 52 patients, the mean follow-up interval was 4.7 years (1 to 11 years). Within the first 6 months after surgery 16 of 57 patients (28%) had died. At follow-up, 21 of 52 patients (40%) had died and 4 patients (8%) lived with major disability (mRS 4 or 5). Twenty-one patients (40%) lived functionally independent (mRS 0 to 2). The presence of additional brain stem infarction was associated with poor outcome (mRS > or =4; hazard ratio: 9.1; P=0.001). Quality of life in survivors was moderately lower than in healthy controls.
  
  
  CONCLUSIONS
  SDC is a safe procedure in patients with malignant cerebellar infarction. Infarct- but not procedure-related early mortality is substantial. Long-term outcome in survivors is acceptable, particularly in the absence of brain stem infarction.
authors: Department of Neurology, Klinikum Grosshadern, University of Munich, Munich, Germany. thomas.pfefferkorn@med.uni-muenchen.de
authors: Thomas
authors: T
authors: Pfefferkorn
authors: Ursula
authors: U
authors: Eppinger
authors: Jennifer
authors: J
authors: Linn
authors: Tobias
authors: T
authors: Birnbaum
authors: Jürgen
authors: J
authors: Herzog
authors: Andreas
authors: A
authors: Straube
authors: Martin
authors: M
authors: Dichgans
authors: Stefan
authors: S
authors: Grau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020526:Brain Stem Infarctions / Q000401:mortality* / Q000601:surgery; D002544:Cerebral Infarction / Q000401:mortality* / Q000601:surgery; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors