Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese.
A recent whole-genome association study identified a strong association between polymorphisms in the prostate stem cell antigen (PSCA) gene and stomach cancer risk. In this case-control study, we aimed to validate this association, and further to explore environmental factors possibly interacting with PSCA polymorphisms in 708 incident stomach cancer cases and 708 age-sex matched controls. The association between PSCA polymorphisms and Helicobacter pylori infection was also examined. We found that rs2294008 and rs2976392, which were strongly linked to each other (D' = 1.00), were significantly associated with stomach cancer risk. Per allele odds ratio for rs2994008 was 1.40 (95% confidence interval: 1.19-1.65; p = 3.7 x 10(-5)). We found significant interaction with a family history of stomach cancer in first-degree relatives (p-heterogeneity = 0.009). Similar to originally reported association, we found significant heterogeneity between diffuse and intestinal type (p-heterogeneity = 0.007). No association was seen between PSCA polymorphisms and H. pylori infection. In conclusion, PSCA polymorphisms are associated with stomach cancer risk in Japanese. A possible interaction with family history warrants further evaluation.
Matsuo
Keitaro
K
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan. t-suzuki@aichi-cc.jp
Tajima
Kazuo
K
Suzuki
Takeshi
T
Kawase
Takakazu
T
Watanabe
Miki
M
Shitara
Kohei
K
Misawa
Kazunari
K
Ito
Seiji
S
Sawaki
Akira
A
Muro
Kei
K
Nakamura
Tsuneya
T
Yamao
Kenji
K
Yamamura
Yoshitaka
Y
Hamajima
Nobuyuki
N
Hiraki
Akio
A
Tanaka
Hideo
H
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm; D016022:Case-Control Studies; D005260:Female; D058851:GPI-Linked Proteins; D016481:Helicobacter Infections / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D007414:Intestinal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D055815:Young Adult
D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; C110843:PSCA protein, human