title: A man with hypogonadotropic hypogonadism successfully treated with nasal administration of the low-dose gonadotropin-releasing hormone analog buserelin.
abstract: OBJECTIVE
  To report a patient with hypogonadotropic hypogonadism of hypothalamic origin successfully treated with nasal administration of a low-dose gonadotropin-releasing hormone (GnRH) analogue.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A reproductive medical center.
  
  
  METHODS
  A 37-year-old man with anejaculation and infertility.
  
  
  METHODS
  Nasal administration of a low-dose GnRH analogue, buserelin.
  
  
  METHODS
  Semen analysis and serum levels of gonadotropins and testosterone after nasal buserelin use.
  
  
  RESULTS
  The patient's laboratory examination showed low serum levels of gonadotropins and testosterone. After being diagnosed with hypogonadotropic hypogonadism, 15 mug of buserelin acetate spray was administrated in each nostril three times a day (total: 90 mug/day). This therapy improved semen parameters and serum gonadotropin and testosterone levels. After approximately 1 year of this treatment, the patient's serum gonadotropin and testosterone levels remained in the normal range and semen analysis showed normozoospermia. The patient and his wife were treated with intracytoplasmic sperm injection, resulting in pregnancy.
  
  
  CONCLUSIONS
  A low-dose buserelin nasal spray appears to be an effective and well-tolerated therapeutic option for patients with hypogonadotropic hypogonadism of hypothalamic origin.
authors: The Reproduction Center, Kiba Park Clinic, Tokyo, Japan. Electronic address: dokumotti@yahoo.co.jp.
authors: Hideki
authors: H
authors: Iwamoto
authors: The Reproduction Center, Kiba Park Clinic, Tokyo, Japan.
authors: Atsumi
authors: A
authors: Yoshida
authors: The Reproduction Center, Kiba Park Clinic, Tokyo, Japan.
authors: Hiroki
authors: H
authors: Suzuki
authors: The Reproduction Center, Kiba Park Clinic, Tokyo, Japan.
authors: Miho
authors: M
authors: Tanaka
authors: The Reproduction Center, Kiba Park Clinic, Tokyo, Japan.
authors: Noriko
authors: N
authors: Watanabe
authors: The Reproduction Center, Kiba Park Clinic, Tokyo, Japan.
authors: Takumi
authors: T
authors: Nakamura
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D002064:Buserelin / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D007248:Infertility, Male / Q000209:etiology; D008297:Male; D055101:Semen Analysis; D013739:Testosterone / Q000097:blood; D016896:Treatment Outcome
chemical_list: D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D002064:Buserelin