Dendritic dopamine: studies on the release of endogenous dopamine from subcellular particles derived from dendrites of rat nigro-striatal neurons.
During subcellular fractionation of rat substantia nigra, the dendrites of the nigro-striatal neurons give rise to particles as terminals do. Release of endogenous dopamine from these particles could be demonstrated with amphetamine but not with potassium. Under identical incubation conditions, subcellular particles derived from the terminal area showed a marked release of endogenous dopamine with both amphetamine and potassium. Also in contrast to the particles from terminals, dendritic particles lost their major content of dopamine during preincubation. The results favor the concept of dendritic dopamine release, but emphasized the difference between dendrites and terminals of the nigro-striatal neurons.
Hefti
F
F
Institute of Pharmacology, University of Zurich, CH-8006 Zurich, Switzerland.
Lichtensteiger
W
W