title: Caloric restriction delays disease onset and mortality in rhesus monkeys.
abstract: Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.
authors: Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA. rcolman@primate.wisc.edu
authors: Ricki J
authors: RJ
authors: Colman
authors: Rozalyn M
authors: RM
authors: Anderson
authors: Sterling C
authors: SC
authors: Johnson
authors: Erik K
authors: EK
authors: Kastman
authors: Kristopher J
authors: KJ
authors: Kosmatka
authors: T Mark
authors: TM
authors: Beasley
authors: David B
authors: DB
authors: Allison
authors: Christina
authors: C
authors: Cruzen
authors: Heather A
authors: HA
authors: Simmons
authors: Joseph W
authors: JW
authors: Kemnitz
authors: Richard
authors: R
authors: Weindruch
mesh_terms: D000375:Aging; D000818:Animals; D001284:Atrophy / Q000453:epidemiology / Q000517:prevention & control; D001835:Body Weight; D001921:Brain / Q000473:pathology*; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D005947:Glucose / Q000378:metabolism; D015994:Incidence; D008136:Longevity; D008253:Macaca mulatta; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D005947:Glucose