title: [Can the botulinum toxin prevent aging?].
abstract: This study wants to prouve that the resting tone is increasing with age. On the behalf of the Face Recurve concept, the deep fat is expelled superficially because of mimic muscle shortening. Botulinum toxin is proposed for a new indication: resting tone decrease in order to slow down muscle shortening and consequently structural aging. Injections can be performed very early in the ageing process, before the appearance at rest of wrinkle, only when it becomes visible in contraction. Precision of the injection is related to the recent determination of motor end plate location in every mimic muscle. Two classical uses, the maximum strength of contraction and the dermal injection, are associated to the action on the resting tone for more evolved cases. Finally, a new possibility for botulinum toxin injection is the blockage of muscular regeneration to stabilize the section of the age marker fascicules performed in the Face Recurve concept. This new indication is also useful in reconstructive surgery for treatment of the marginal mandibular lip deformity in patients with chronic unilateral facial palsies.
authors: Lelouarn-claude@noos.fr
authors: C
authors: C
authors: Le Louarn
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000328:Adult; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005145:Face; D005149:Facial Expression; D005152:Facial Muscles / Q000187:drug effects*; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D009045:Motor Endplate / Q000187:drug effects; D009334:Neck Muscles / Q000187:drug effects; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012060:Rejuvenation; D012146:Rest; D012189:Retrospective Studies; D015595:Skin Aging / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D009465:Neuromuscular Agents; D001905:Botulinum Toxins