Gender effects in relapsing-remitting multiple sclerosis: correlation between clinical variables and gene expression molecular pathways.
Gene expression profiles were assessed in patients with relapsing-remitting multiple sclerosis (RRMS) to identify gender effects. Clear gender differences in time to second relapse and time to EDSS=6.0 progression in patients with late onset of the disease (>40years) were evident, and occurred more rapidly in female RRMS patients. Identified molecular biological mechanisms were related to increased immune activation associated with prominent inhibition of apoptosis that enhanced inflammatory processes and were more evident in female RRMS patients. Our findings open possibilities to explore gender-dependent immunomodulatory treatments that will be based on gene expression mechanisms that set the difference between male and female RRMS patients.
Achiron
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Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel. achiron@post.tau.ac.il
Gurevich
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M
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000704:Analysis of Variance; D002648:Child; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000378:metabolism* / Q000503:physiopathology*; D020411:Oligonucleotide Array Sequence Analysis; D025341:Principal Component Analysis; D012189:Retrospective Studies; D012737:Sex Factors; D012744:Sex Ratio; D055815:Young Adult