title: Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature infections with Toxocara canis and Toxascaris leonina in dogs.
abstract: The efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature adult, immature adult and larval stages of Toxocara canis and Toxascaris leonina was evaluated in ten randomised, blinded and placebo-controlled dose confirmation studies in naturally or experimentally infected dogs. The tablets were used at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. Efficacy was calculated based on worm counts after necropsy. Five studies demonstrated >99% efficacy against mature adult, >92% efficacy against immature adult, >98% efficacy against L4 and >94% efficacy against L3 larval stages of T. canis. Another five studies demonstrated >99% efficacy against mature and immature adult and >95% efficacy against L4 larval stages of T. leonina. No side effects of the treatment were observed. Emodepside plus praziquantel tablets thus provide a comprehensive new treatment option for ascarid infections in the dog.
authors: Bayer Animal Health GmbH, Leverkusen, Germany. gertraut.altreuther@bayerhealthcare.com
authors: Gertraut
authors: G
authors: Altreuther
authors: Annette
authors: A
authors: Schimmel
authors: Iris
authors: I
authors: Schroeder
authors: Thomas
authors: T
authors: Bach
authors: Samuel
authors: S
authors: Charles
authors: Dawid J
authors: DJ
authors: Kok
authors: Friederike
authors: F
authors: Kraemer
authors: Sonja
authors: S
authors: Wolken
authors: David
authors: D
authors: Young
authors: Klemens J
authors: KJ
authors: Krieger
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D047630:Depsipeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004311:Double-Blind Method; D005243:Feces / Q000469:parasitology; D010270:Parasite Egg Count; D010919:Placebos / Q000008:administration & dosage; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D013607:Tablets / Q000008:administration & dosage / Q000627:therapeutic use; D017227:Toxascariasis / Q000188:drug therapy / Q000662:veterinary*; D014114:Toxascaris / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D047630:Depsipeptides; D010919:Placebos; D013607:Tablets; D011223:Praziquantel; C468987:emodepside