title: No association of three GRIN2B polymorphisms with lithium response in bipolar patients.
abstract: We investigated three polymorphisms in the NMDA receptor 2B subunit gene (GRIN2B) as a candidate gene for lithium response involved in glutamatergic neurotransmission. One hundred five bipolar patients treated with lithium for at least 5 years were analyzed. The lithium response was assessed as excellent - no affective episodes during lithium treatment; partial - 50% reduction in the episode index; or no response - less than 50% reduction, no change or worsening in the episode index. Genotypes for the -200G/T, 366C/G and rs890G/T GRIN2B polymorphisms were established using the PCR-RFLP method. Genotype distributions were in Hardy-Weinberg equilibrium for all three polymorphisms. No association was found between the three polymorphisms studied and the treatment response to lithium. The authors conclude that polymorphisms of the GRIN2B gene did not show an association with the treatment response to lithium in bipolar patients.
authors: Psychiatric Genetics Unit, Department of Psychiatry, Poznań University of Medical Sciences, Poland. alszczep@amp.edu.pl
authors: Aleksandra
authors: A
authors: Szczepankiewicz
authors: Maria
authors: M
authors: Skibińska
authors: Aleksandra
authors: A
authors: Suwalska
authors: Joanna
authors: J
authors: Hauser
authors: Janusz K
authors: JK
authors: Rybakowski
mesh_terms: D001714:Bipolar Disorder / Q000188:drug therapy / Q000235:genetics*; D015331:Cohort Studies; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D018020:Lithium Compounds; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate