[Resolution of chiral molecules of pharmaceutical interest by means of preferential crystallization].
Various aspects of the chiral discrimination in the solid state are examined. The interests of the conglomerate are illustrated by two applications: the preparative enantiomeric purification and the preferential crystallization. The latter process is described by a careful examination of the heterogeneous equilibria that govern the crystallization and its selectivity. Two variants of the preferential crystallization are detailed. A "good" example illustrates the productivity at the laboratory scale. The ratio between homochiral interaction energies and heterochiral interaction energies at different (hkl) interfaces are involved in the "difficult" cases where the entrainment effect is limited.
Coquerel
G
G
Unité de Croissance Cristalline et de Modélisation Moléculaire, Université de Rouen, 76821 Mont Saint-Aignan cedex, France. gerard.coquerel@univ-rouen.fr
D003460:Crystallization; D004345:Drug Industry / Q000379:methods; D006801:Humans; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000302:isolation & purification; D012997:Solvents; D013237:Stereoisomerism
D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D012997:Solvents