Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders.
Epistasis, the interaction between genes, is a topic of current interest in molecular and quantitative genetics. We have further studied a previously investigated sample of 187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients, and 288 controls, and tried to analyze the interaction between a set of variations of independent genes: the trace amine receptor 6 (rs4305745, rs8192625, rs7452939, rs6903874, and rs6937506) and the heat shock protein 70 (rs562047, rs1061581, rs2227956). The multifactor dimensionality reduction (MDR) method was applied and the covariates associated with diagnosis were also controlled. A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. The level of statistical significance (P < 0.001) and the testing balancing accuracy over 0.62 suggest a cautious optimism toward this result, although the possibility of false positivity warrants further analyses in independent samples.
Pae
Chi-Un
CU
Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea.|Department of Psychiatry and Behavioural Sciences, Duke University Medical Center, Durham, North Carolina.
Drago
Antonio
A
Institute of Psychiatry, University of Bologna, Bologna, Italy.
Forlani
Martina
M
Institute of Psychiatry, University of Bologna, Bologna, Italy.
Patkar
Ashwin A
AA
Department of Psychiatry and Behavioural Sciences, Duke University Medical Center, Durham, North Carolina.
Serretti
Alessandro
A
Institute of Psychiatry, University of Bologna, Bologna, Italy.
D000483:Alleles; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics; D004843:Epistasis, Genetic; D014644:Genetic Variation; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008957:Models, Genetic; D019964:Mood Disorders / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled; D015203:Reproducibility of Results; D000095383:Trace Amine-Associated Receptors
D018797:Cell Cycle Proteins; D018840:HSP70 Heat-Shock Proteins; D009687:Nuclear Proteins; D043562:Receptors, G-Protein-Coupled; C493988:TAAR6 protein, human; D000095383:Trace Amine-Associated Receptors