title: Relation between the concentration of zinc in maternal whole blood and the risk of an infant being born with an orofacial cleft.
abstract: We investigated the relation between concentrations of maternal zinc and copper and the risk of an infant being born with an orofacial cleft. We did a case-control study using 116 mothers of children with isolated cleft lip with or without cleft palate (cleft group), and 64 mothers of unaffected children (control group). Mothers with a whole blood zinc concentration of 47.1 micromol/L or less had a risk 2.5 times higher of having a child with an orofacial cleft than those with a higher concentration (or level) (95% CI 1.03-6.23; p<0.05). A low zinc concentration combined with a high copper concentration was seen only in the cleft group. This evidence suggests an association between concentrations of maternal zinc and the risk of orofacial clefts in offspring.
authors: Department of Paediatrics, Institute of Mother and Child, Kasprzaka 17a, 01-211 Warsaw, Poland. kamil.hozyasz@imid.med.pl
authors: K K
authors: KK
authors: Hozyasz
authors: M
authors: M
authors: Kaczmarczyk
authors: J
authors: J
authors: Dudzik
authors: E
authors: E
authors: Bulska
authors: Z
authors: Z
authors: Dudkiewicz
authors: M
authors: M
authors: Szymanski
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002971:Cleft Lip / Q000209:etiology*; D002972:Cleft Palate / Q000209:etiology*; D003300:Copper / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D013058:Mass Spectrometry; D016017:Odds Ratio; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena; D012189:Retrospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric; D055815:Young Adult; D015032:Zinc / Q000097:blood* / Q000172:deficiency*
chemical_list: D003300:Copper; D015032:Zinc