title: Mosquito larvicidal activities of extractives from black heartwood-type Cryptomeria japonica.
abstract: The purpose of this study is to determine the larvicidal activities of ethanolic extracts from leaves, wood, and bark of black heartwood-type Cryptomeria japonica against fourth-instar larvae of mosquitoes Aedes aegypti and Aedes albopictus. Among three ethanolic extracts from C. japonica, wood extract exhibited the best larvicidal activity against A. aegypti and A. albopictus with LC(50) values of 63.2 and 93.8 microg/ml, respectively. Four major compounds, including ferruginol, epi-cubebol, cubebol, and isopimarol, were isolated from wood extract, and it was demonstrated that cubebol exhibited the best activity against A. aegypti and A. albopictus with LC(50) values of 60.1 and 50.0 microg/ml, respectively. Our findings showed that the wood extract and cubebol from C. japonica have good potential as a source for natural larvicides.
authors: School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan.
authors: Hui-Jing
authors: HJ
authors: Gu
authors: Sen-Sung
authors: SS
authors: Cheng
authors: Chin-Gi
authors: CG
authors: Huang
authors: Wei-June
authors: WJ
authors: Chen
authors: Shang-Tzen
authors: ST
authors: Chang
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D032485:Cryptomeria / Q000737:chemistry*; D006801:Humans; D007306:Insecticides / Q000302:isolation & purification* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D016019:Survival Analysis; D014934:Wood / Q000737:chemistry
chemical_list: D007306:Insecticides; D010936:Plant Extracts; D012717:Sesquiterpenes; C442120:cubebol