[Sorting, recycling and WNT signaling: Wntless and retromer functions].
Cell-cell signaling is essential for the development of multi-cellular organisms. Indeed, membrane traffic is required for the correct sorting and function of receptors and ligands. In the past decades, many genetic screens performed in C. elegans and Drosophila have been crucial to identify the role of intracellular traffic in signaling. In this review, we discuss recent work that led to the identification of Wntless, a sorting receptor for WNT, and of the retromer, a protein complex required for the recycling of Wntless from endosomes to the trans-Golgi network.
Michaux
Grégoire
G
Equipe Avenir Inserm, Institut de génétique et développement de Rennes, CNRS UMR 6061-Faculté de médecine, CS 34317, 2, avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France. gmichaux@univ-rennes1.fr
Le Borgne
Roland
R
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D004330:Drosophila / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D051153:Wnt Proteins