Klebsiella pneumoniae brain abscess in neonates: a report of 2 cases.
Brain abscesses are uncommon in neonates. Klebsiella pneumoniae is a very uncommon microbial agent to cause brain abscess. We report 2 infants with Klebsiella pneumoniae sepsis who developed brain abscesses. One infant was a premature neonate who required mechanical ventilation for respiratory distress syndrome and subsequently developed nosocomial sepsis and brain abscess without evidence of preceding meningitis. Another infant was a full-term neonate without risk factors for sepsis who developed seizures on the sixth postnatal day and was found to have meningitis and brain abscess. Both infants had Klebsiella pneumoniae septicemia with multiple relatively large brain abscesses that responded poorly to antimicrobial agents. These infants were managed with transfontanel drainage and prolonged courses of antimicrobial agents. Key message of this report is that Klebsiella pneumoniae brain abscess may occur in the absence of meningitis and even in the absence of any identifiable risk factors.
Sundaram
Venkataseshan
V
Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. sesh6@rediffmail.com
Agrawal
Sunil
S
Chacham
Swathi
S
Mukhopadhyay
Kanya
K
Dutta
Sourabh
S
Kumar
Praveen
P
D001921:Brain / Q000000981:diagnostic imaging; D001922:Brain Abscess / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007710:Klebsiella Infections / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D007711:Klebsiella pneumoniae; D008297:Male; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome