Scrub typhus (Orientia tsutsugamushi), spotted fever (Rickettsia australis) and dengue fever as possible causes of mysterious deaths in the Strickland Gorge area of Southern Highlands and West Sepik Provinces of Papua New Guinea.
A medical investigation was carried out in April 2001 into an outbreak of a mysterious haemorrhagic disease and deaths in the remote picturesque Strickland River area of Papua New Guinea (PNG). The area is in part of the Southern Highlands and West Sepik Provinces and situated downstream from the Porgera Joint Venture gold mine. 9 villages were visited and 140 persons, consisting of immediate blood relatives of the deceased (cases) and others in the village picked at random (controls), were physically examined. Specimens of blood, urine and faeces were collected from each person for laboratory tests in PNG and Australia. Positive sera for dengue (15%) and Japanese encephalitis (JE) (6%) were identified. Surprisingly, a number of the sera were positive for scrub typhus (Orientia tsutsugamushi) (28%) and spotted fever (Rickettsia australis) (11%). The last reported cases of scrub typhus in PNG were during World War Two among the allied troops. This is the first time spotted fever (R. australis) has been reported in PNG. These conditions may have been the cause of the deaths described by the villagers. However, there were significantly more dengue-positive results among relatives of the deceased than non-relatives though no such difference was found with rickettsial infections: haemorrhagic dengue fever is thus the most likely cause of this recurring outbreak. Mining did not appear to be a direct causal factor for the deaths in the area.
Spicer
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HMAS Cairns Naval Base, Australia.
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Benjamin
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D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010219:Papua New Guinea / Q000453:epidemiology; D011159:Population Surveillance; D015995:Prevalence; D012189:Retrospective Studies; D012282:Rickettsia Infections / Q000175:diagnosis / Q000401:mortality*; D012424:Rural Population; D012612:Scrub Typhus / Q000175:diagnosis / Q000401:mortality*; D012698:Serologic Tests; D019595:Severe Dengue / Q000175:diagnosis / Q000401:mortality*; D055815:Young Adult