title: The COMPARE Registry: design and baseline patterns of care for men with biochemical failure after definitive treatment of localized prostate cancer.
abstract: OBJECTIVE
  To define current standards of care for patients with prostate-specific antigen (PSA) failure after initial definitive local treatment of prostate cancer using Comprehensive, Observational, Multicenter, Prostate Adenocarcinoma Registry (COMPARE). This article describes the design of the COMPARE Registry, together with patient characteristics and prostate cancer management at enrolment.
  
  
  METHODS
  The COMPARE Registry is a prospective, multicenter, observational study that collected data on patient characteristics, management practices, and outcomes of men presenting to their physician for the management of an increasing PSA level after definitive (surgical or radiotherapeutic) treatment of localized prostate cancer. Data collected by the physician and reported by the patient at the baseline (enrolment) visit are described.
  
  
  RESULTS
  Between February 2004 and March 2007, 1120 men were enrolled at 150 sites throughout the United States. The men had a median age of 73 years (range, 46-95 years), were predominantly white (77%), and had a median PSA level of 7.9 ng/mL (range, 0-710.8 ng/mL) at diagnosis. Observation (74%) was the most common initial management choice at registry enrolment, and androgen-deprivation therapy (22%) was the most common initial treatment choice.
  
  
  CONCLUSIONS
  Data from the COMPARE Registry should provide a valuable source of prospectively collected information on the contemporary management of prostate cancer and patient outcomes after PSA failure.
authors: Department of Medicine, Tulane University, New Orleans, Louisiana 70115, USA. osartor@tulane.edu
authors: Oliver
authors: O
authors: Sartor
authors: David G
authors: DG
authors: McLeod
authors: Susan
authors: S
authors: Halabi
authors: Paul F
authors: PF
authors: Schellhammer
authors: Peter T
authors: PT
authors: Scardino
authors: Anthony V
authors: AV
authors: D'Amico
authors: Charles
authors: C
authors: Bennett
authors: John T
authors: JT
authors: Wei
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000628:therapy*; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000628:therapy*; D012042:Registries; D017211:Treatment Failure; D014481:United States
chemical_list: D017430:Prostate-Specific Antigen