How to be naive.
The transcription factor KLF2 directs expression of receptors involved in trafficking of naive T cells. In this issue of Immunity, Weinreich et al. (2009) demonstrate that KLF2 additionally represses IL-4 production, which otherwise induces CXCR3 expression.
Stein
Jens V
JV
Theodor Kocher Institute, University of Bern, Freiestr. 1, 3012 Bern, Switzerland. jstein@tki.unibe.ch
D000818:Animals; D016207:Cytokines / Q000276:immunology; D015847:Interleukin-4 / Q000276:immunology*; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000502:physiology*; D051379:Mice; D054367:Receptors, CXCR3 / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016207:Cytokines; C498314:Klf2 protein, mouse; D051741:Kruppel-Like Transcription Factors; D054367:Receptors, CXCR3; D015847:Interleukin-4