title: 3-Keto-22-epi-28-nor-cathasterone, a brassinosteroid-related metabolite from Cystoseira myrica.
abstract: Bioassay-guided purification of an ethanolic extract of Cystoseira myrica against HEPG-2 (liver) and HCT116 (colon) human cancer cell lines led to the isolation of 3-keto-22-epi-28-nor-cathasterone, 1 and cholest-4-ene-3,6-dione, 2. This finding allowed us to report for the first time that a brassinosteroid-related metabolite occurs in seaweed. These compounds showed activity in the range of 12.38-1.16 microM with selective activity of compound 2 to liver cancer cell lines.
authors: Chemistry of Natural and Microbial Products Department, NRC, Cairo, Egypt.
authors: Abdel-Hamid A
authors: AH
authors: Hamdy
authors: Elsayed A
authors: EA
authors: Aboutabl
authors: Somayah
authors: S
authors: Sameer
authors: Ahmed A
authors: AA
authors: Hussein
authors: Ana R
authors: AR
authors: Díaz-Marrero
authors: José
authors: J
authors: Darias
authors: Mercedes
authors: M
authors: Cueto
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D000459:Phaeophyceae / Q000378:metabolism*; D010840:Phytosterols / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology
chemical_list: C545871:3-keto-28-norcathasterone; D000970:Antineoplastic Agents; D010840:Phytosterols; D013256:Steroids