The gutsy side of bone.
Though surgical removal of the stomach has long been linked to low bone mass, the molecular mechanism has been elusive. Amling and coworkers now demonstrate that gastric cell acid production is necessary for calcium absorption. Mice lacking this acidification develop hypocalcemia, with increased parathyroid hormone and osteoclast differentiation, and decreased bone mass.
Ferron
Mathieu
M
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Karsenty
Gerard
G
D000818:Animals; D015519:Bone Density / Q000502:physiology*; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002454:Cell Differentiation; D005753:Gastric Mucosa / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D006996:Hypocalcemia / Q000150:complications / Q000235:genetics / Q000378:metabolism; D051379:Mice; D010010:Osteoclasts / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism; D013270:Stomach / Q000601:surgery
D010281:Parathyroid Hormone; D002118:Calcium