title: Cellular efflux of cAMP and cGMP - a question about selectivity.
abstract: The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5 (MRP5) and ABCC11 (MRP8) as cellular efflux pumps for cAMP and cGMP. These transporters are potential drug targets for selective modulation of cyclic nucleotide action.
authors: Faculty of Medicine, Institute of Medical Biology, Department of Pharmacology, University of Tromsø, N- 9037 Tromsø, Norway. georg.sager@fagmed.uit.no
authors: Georg
authors: G
authors: Sager
authors: Aina Westrheim
authors: AW
authors: Ravna
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D013379:Substrate Specificity
chemical_list: D018528:ATP-Binding Cassette Transporters; D000242:Cyclic AMP; D006152:Cyclic GMP