The organocatalytic addition of bis(arylsulfonyl)methane to alpha,beta-unsaturated aldehydes and the synthesis of optically-enriched 3-methyl-alkanols.
An indirect organocatalytic method for the beta-methylation of alpha,beta-unsaturated aldehydes that involves the addition of bis(arylsulfonyl)methane catalyzed by prolinol derivatives and further elimination of the chameleonic sulfonyl groups is presented.
García Ruano
José Luis
JL
Departamento de Química Orgánica (C-I), Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid, Spain. joseluis.garcia.ruano@uam.es
Marcos
Vanesa
V
Alemán
José
J