title: Delayed improvement of insulin secretion after autologous islet transplantation in partially pancreatectomized patients.
abstract: The purpose of this study was to evaluate the effects of autologous islet transplantation (ITx) on glucose homeostasis and insulin secretory function after partial pancreatectomy (Px). Fourteen nondiabetic patients who underwent distal Px and autologous ITx for benign pancreatic tumors were enrolled in the study (Px + ITx group). Fourteen normal glucose-tolerant controls and 6 Px without ITx controls were recruited, and all groups were followed over a 24-month period. They performed the 75-g oral glucose tolerance test and the 1-mg glucagon stimulation test. Hemoglobin A(1c) was measured, and indices of insulin secretion were calculated. In the Px + ITx group, insulin secretion increased after a nadir at 6 months. Glucose tolerance, which had been abruptly impaired immediately after Px, recovered until 6 months and stabilized thereafter. As a result, differences in glucose intolerance emerged between the subjects in the Px group and those in the Px + ITx group at 24 months after Px. Characteristic variables in the better insulin secretory subjects in the Px + ITx group included younger age, less extensive pancreas resection, and a greater number of total islets. In summary, delayed amelioration of glucose intolerance was induced by autologous ITx after partial Px, even with a small number of islets.
authors: Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
authors: Hye Seung
authors: HS
authors: Jung
authors: Seong-Ho
authors: SH
authors: Choi
authors: Sung-Joo
authors: SJ
authors: Kim
authors: Dong-Wook
authors: DW
authors: Choi
authors: Jin-Seok
authors: JS
authors: Heo
authors: Kyu Taek
authors: KT
authors: Lee
authors: Jong Kyun
authors: JK
authors: Lee
authors: Kee-Taek
authors: KT
authors: Jang
authors: Byung-Wan
authors: BW
authors: Lee
authors: Jae-Hwan
authors: JH
authors: Jee
authors: Jung-Hyun
authors: JH
authors: Noh
authors: In Kyung
authors: IK
authors: Jeong
authors: Tae-Young
authors: TY
authors: Yang
authors: Seung-Hoon
authors: SH
authors: Oh
authors: You-Ran
authors: YR
authors: Ahn
authors: Young-Seok
authors: YS
authors: Kim
authors: Heesung
authors: H
authors: No
authors: Moon-Kyu
authors: MK
authors: Lee
authors: Kwang-Won
authors: KW
authors: Kim
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology; D005260:Female; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance / Q000517:prevention & control; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood*; D016381:Islets of Langerhans Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000601:surgery
chemical_list: D005947:Glucose; D006442:Glycated Hemoglobin; D007328:Insulin