title: Treatment of naturally occurring, asymptomatic Giardia sp. in dogs with Drontal Plus flavour tablets.
abstract: The administration of three consecutive daily doses of the recommended 1x dose of Drontal Plus flavour tablets (Bayer) was examined for its effect on Giardia sp. cyst-shedding in 7 treated and 7 untreated random-source dogs. Dogs were treated on study days 0, 1 and 2. Cysts were quantified using direct immunofluorescent labelling on days -7, -5, -3 and -2, and daily from day 1 through 11. Three treated dogs never shed cysts again during the study, one shed again only on day 4, and the remaining three dogs started to shed again on days 8, 9 and 11. The mean numbers of cysts per gramme in the faeces of the treated dogs were significantly reduced (t-tests using log(10)(counts)) on days 1 and 2 (geometric means: controls = 447,000; treated = 1,050; p = 0.004) and days 3 to 8 (geometric means: controls = 23,400; treated 5.0; p < 0.001). Four controls that had been consistently positive, changed to negative status on day 11, and thus, on the final day of the trial, there were only three positive control and three positive treated dogs. Three consecutive days of treatment with Drontal Plus flavour tablets halted Giardia sp. cyst shedding by dogs. But starting six days post third treatment, some of the dogs started shedding cysts again. Since the prepatent period of Giardia sp. can be as short as 4 days, shedding of Giardia sp. cysts 6 days after treatment could be caused by a reinfection.
authors: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, USA. ddb3@cornell.edu
authors: Dwight D
authors: DD
authors: Bowman
authors: Janice L
authors: JL
authors: Liotta
authors: Michael
authors: M
authors: Ulrich
authors: Sam D
authors: SD
authors: Charles
authors: Josef
authors: J
authors: Heine
authors: Roland
authors: R
authors: Schaper
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D005872:Giardia / Q000187:drug effects*; D005873:Giardiasis / Q000188:drug therapy / Q000662:veterinary*; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use*; D010270:Parasite Egg Count; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D011716:Pyrantel Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*; D013607:Tablets / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D004338:Drug Combinations; D006146:Guanidines; D013607:Tablets; D011223:Praziquantel; D011716:Pyrantel Pamoate; C017309:febantel