title: Hepatitis B virus and hepatitis delta virus genotypes in outbreaks of fulminant hepatitis (Labrea black fever) in the western Brazilian Amazon region.
abstract: The genotypes of hepatitis B (HBV) and delta (HDV) viruses circulating among fulminant hepatitis cases from the western Amazon Basin of Brazil were characterized in this study. HBV and HDV isolates were obtained from liver samples from 14 patients who developed fulminant hepatitis and died during 1978-1989. HBV DNA and HDV RNA were detected in all samples. Phylogenetic analyses of HDV sequences showed that they all clustered with previously characterized sequences of HDV genotype 3 (HDV-3). HBV genotypes F, A and D were found in 50.0, 28.6 and 21.4 % of cases, respectively. These results confirm the predominance of HDV-3 in South America and its association with the severe form of hepatitis, and the finding of the co-infection of HDV-3 with different genotypes of HBV suggests that the association between HDV-3 and HBV-F is not necessarily causally related to a more severe clinical course of infection.
authors: Seção de Hepatologia, Instituto Evandro Chagas, Avenida Almirante Barroso 492, Belém, PA 66090-000, Brazil.|Laboratory of Tropical Hepatology and Gastroenterology, Tropical Medicine Institute, Department of Gastroenterology, University of São Paulo Medical School, Av. Dr Enéas Carvalho de Aguiar 500, São Paulo, SP 05403-000, Brazil.
authors: M S
authors: MS
authors: Gomes-Gouvêa
authors: Seção de Hepatologia, Instituto Evandro Chagas, Avenida Almirante Barroso 492, Belém, PA 66090-000, Brazil.
authors: M C P
authors: MCP
authors: Soares
authors: Seção de Hepatologia, Instituto Evandro Chagas, Avenida Almirante Barroso 492, Belém, PA 66090-000, Brazil.
authors: G
authors: G
authors: Bensabath
authors: Laboratório de Imunologia Viral, Instituto Butantan, Avenida Vital Brasil 1500, São Paulo, SP 05503-900, Brazil.|Laboratory of Tropical Hepatology and Gastroenterology, Tropical Medicine Institute, Department of Gastroenterology, University of São Paulo Medical School, Av. Dr Enéas Carvalho de Aguiar 500, São Paulo, SP 05403-000, Brazil.
authors: I M V G
authors: IMVG
authors: de Carvalho-Mello
authors: Seção de Hepatologia, Instituto Evandro Chagas, Avenida Almirante Barroso 492, Belém, PA 66090-000, Brazil.
authors: E M F
authors: EMF
authors: Brito
authors: Seção de Hepatologia, Instituto Evandro Chagas, Avenida Almirante Barroso 492, Belém, PA 66090-000, Brazil.
authors: O S C
authors: OSC
authors: Souza
authors: Instituto de Biociências, Universidade de São Paulo, Rua do Matão 277, São Paulo, SP 05508-900, Brazil.
authors: A T L
authors: ATL
authors: Queiroz
authors: Laboratory of Tropical Hepatology and Gastroenterology, Tropical Medicine Institute, Department of Gastroenterology, University of São Paulo Medical School, Av. Dr Enéas Carvalho de Aguiar 500, São Paulo, SP 05403-000, Brazil.
authors: F J
authors: FJ
authors: Carrilho
authors: Laboratory of Tropical Hepatology and Gastroenterology, Tropical Medicine Institute, Department of Gastroenterology, University of São Paulo Medical School, Av. Dr Enéas Carvalho de Aguiar 500, São Paulo, SP 05403-000, Brazil.
authors: J R R
authors: JRR
authors: Pinho
mesh_terms: D001938:Brazil / Q000453:epidemiology; D016000:Cluster Analysis; D004279:DNA, Viral / Q000235:genetics; D004196:Disease Outbreaks; D005838:Genotype; D006509:Hepatitis B / Q000453:epidemiology* / Q000821:virology; D006515:Hepatitis B virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D003699:Hepatitis D / Q000453:epidemiology* / Q000821:virology; D003698:Hepatitis Delta Virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008099:Liver / Q000821:virology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral