[Diagnosis and surgical treatment for non-functional islet cell tumor: a retrospective analysis of 44 cases].
OBJECTIVE
To evaluate the methods of diagnosis and surgical treatment for nonfunctional islet cell tumor (NICT).


METHODS
Forty-four patients with non-functional islet cell tumor treated at the First Affiliated Hospital of Nanjing Medical University during January 1968 to June 2008 were analyzed retrospectively. There were 9 males and 35 females, aged from 7- to 70-years-old. Clinical manifestation: 15 cases (34.1%) of abdominal masses, 17 patients (38.6%) with epigastric or back pain, 5 cases of jaundice, 5 cases (11.4%) for upper abdominal fullness or vomiting, 10 cases (22.7%) of pancreatic tumor noticed by routine health checkups or imaging examinations. Imaging examination: CT scan, sonography, ERCP, MRI, upper GI series were performed in 33 (75.0%), 16 (36.4%), 6 (13.6%), 2 (4.5%), and 10 cases (22.7%) respectively. Operation methods: 39 patients (88.6%) underwent surgical resection and the other 5 patients did not.


RESULTS



RESULTS
pancreatic fistula in 7 patients (15.9%), intra-abdominal bleeding in 4 (9.1%), gastrojejunal anastomosis outlet obstruction in 1 (2.3%), biliary fistula in 2 (4.5%) and incisional infection in 3 (6.8%). Surgery related mortality happened in 2 patients (4.5%), both treated before 1999. Twenty-five patients underwent operation between January 1999 and June 2008 were followed up for 6 to 108 months. All survive except one died 75 months after the surgery for unknown reason.


CONCLUSIONS
No specific clinical manifestation is recognized for non-functional islet cell tumor. Spiral CT is an optimal diagnostic method, while surgery is the first choice for treatment. Middle segmental pancreatectomy has become an alternative surgical protocol for NICT.
Jiang
Kui-rong
KR
Center for Pancreatic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Miao
Yi
Y
Xu
Ze-kuan
ZK
Qian
Zhu-yin
ZY
Dai
Cun-cai
CC
Xie
Li
L
Wu
Jun-li
JL
Li
Qiang
Q
Xi
Chun-hua
CH
Guo
Feng
F
Chen
Jian-min
JM
Gao
Wen-tao
WT
Liu
Xun-Liang
XL
D007516:Adenoma, Islet Cell / Q000175:diagnosis* / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult