title: Colloidal polymeric nanoparticles and brain drug delivery.
abstract: The blood brain barrier protects the brain from harmful substances in the blood stream and has stopped the development of many powerful and interesting drugs candidates for central nervous system due to the low poor distribution and by efflux mechanisms. Many different approaches have been developed in order to overcome this barrier and the drug gain access to the brain. The polymeric nanoparticles are efficient colloidal systems that have been investigated to the brain drug delivery. This review will focus on the current strategies for brain drug delivery emphasizing the properties and characteristics of polymeric nanoparticles for this purpose.
authors: Departamento de Farmácia - Universidade Estadual do Centro-Oeste / UNICENTRO - Guarapuava, Brasil.
authors: Najeh Maissar
authors: NM
authors: Khalil
authors: Rubiana Mara
authors: RM
authors: Mainardes
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology; D001927:Brain Diseases / Q000188:drug therapy*; D003102:Colloids; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry
chemical_list: D003102:Colloids; D004364:Pharmaceutical Preparations; D011108:Polymers