title: A crystallized view of AMPK activation.
abstract: AMP-activated protein kinase (AMPK) is a key metabolic regulator. Recent work (Chen et al., 2009) elucidates the structural interaction between the autoinhibitory sequence and the kinase domain of the AMPK catalytic subunit. Enhanced understanding of the molecular mechanics of AMPK activation might lead to novel therapeutic approaches.
authors: Section of Cardiovascular Medicine, Departments of Internal Medicine and Physiology, Yale University School of Medicine, New Haven, CT 06520, USA. lawrence.young@yale.edu
authors: Lawrence H
authors: LH
authors: Young
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000737:chemistry / Q000378:metabolism*; D000249:Adenosine Monophosphate / Q000378:metabolism; D001665:Binding Sites; D004789:Enzyme Activation; D017434:Protein Structure, Tertiary
chemical_list: D000249:Adenosine Monophosphate; D055372:AMP-Activated Protein Kinases